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Search of human proteins with 169636420
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169636420 carbonic anhydrase IX precursor [Homo sapiens]
(459 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169636420 carbonic anhydrase IX precursor [Homo sapiens] 937 0.0
gi|6912284 carbonic anhydrase XIV precursor [Homo sapiens] 213 3e-55
gi|4502515 carbonic anhydrase XII isoform 1 precursor [Homo sapi... 201 1e-51
gi|45935383 carbonic anhydrase XII isoform 2 precursor [Homo sap... 197 2e-50
gi|70167127 carbonic anhydrase VI precursor [Homo sapiens] 192 4e-49
gi|4885101 carbonic anhydrase VII isoform 1 [Homo sapiens] 155 9e-38
gi|22027500 carbonic anhydrase VIII [Homo sapiens] 155 9e-38
gi|4557395 carbonic anhydrase II [Homo sapiens] 145 1e-34
gi|38348436 carbonic anhydrase XIII [Homo sapiens] 143 4e-34
gi|192447434 carbonic anhydrase I [Homo sapiens] 136 3e-32
gi|192447432 carbonic anhydrase I [Homo sapiens] 136 3e-32
gi|192447430 carbonic anhydrase I [Homo sapiens] 136 3e-32
gi|4502517 carbonic anhydrase I [Homo sapiens] 136 3e-32
gi|62240989 carbonic anhydrase VII isoform 2 [Homo sapiens] 130 2e-30
gi|4885099 carbonic anhydrase III [Homo sapiens] 130 2e-30
gi|6005723 carbonic anhydrase VB, mitochondrial precursor [Homo ... 130 3e-30
gi|4502521 carbonic anhydrase VA, mitochondrial precursor [Homo ... 125 8e-29
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 124 1e-28
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 115 8e-26
gi|4502519 carbonic anhydrase IV precursor [Homo sapiens] 111 2e-24
gi|130979954 carbonic anhydrase X [Homo sapiens] 99 8e-21
gi|130979679 carbonic anhydrase X [Homo sapiens] 99 8e-21
gi|9910366 carbonic anhydrase X [Homo sapiens] 99 8e-21
gi|9951923 carbonic anhydrase XI precursor [Homo sapiens] 95 2e-19
gi|239756368 PREDICTED: similar to acidic (leucine-rich) nuclear... 50 4e-06
gi|239750893 PREDICTED: similar to acidic (leucine-rich) nuclear... 50 4e-06
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 47 4e-05
gi|110349719 titin isoform N2-A [Homo sapiens] 47 5e-05
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 45 1e-04
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ... 45 1e-04
>gi|169636420 carbonic anhydrase IX precursor [Homo sapiens]
Length = 459
Score = 937 bits (2423), Expect = 0.0
Identities = 459/459 (100%), Positives = 459/459 (100%)
Query: 1 MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL 60
MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
Sbjct: 1 MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL 60
Query: 61 GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG 120
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
Sbjct: 61 GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG 120
Query: 121 DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL 180
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
Sbjct: 121 DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL 180
Query: 181 ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT 240
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
Sbjct: 181 ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT 240
Query: 241 VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA 300
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
Sbjct: 241 VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA 300
Query: 301 EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS 360
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
Sbjct: 301 EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS 360
Query: 361 DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF 420
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
Sbjct: 361 DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF 420
Query: 421 GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA 459
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
Sbjct: 421 GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA 459
>gi|6912284 carbonic anhydrase XIV precursor [Homo sapiens]
Length = 337
Score = 213 bits (542), Expect = 3e-55
Identities = 128/330 (38%), Positives = 175/330 (53%), Gaps = 26/330 (7%)
Query: 136 DDQSHWRYGG---DPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPE 192
D HW Y G WP P C QSP+DI+ F P L L+ G+ P
Sbjct: 17 DGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEP 76
Query: 193 LRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPG-SEHTVEGHRFPAEIH 251
L L NNGH+VQL+LP L + G R+Y A QLHLHWG G PG SEH + AE+H
Sbjct: 77 LDLHNNGHTVQLSLPSTLYLG-GLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELH 135
Query: 252 VVHL-STAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPG 310
+VH S ++ + EA RP GLAVL +E G +N AYE +LS L E+ + +T VP
Sbjct: 136 IVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPP 195
Query: 311 LDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSR 370
++ LLP +YF+Y GSLTTPPC Q V+WTVF + +S +QL L TL+ +
Sbjct: 196 FNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEP 255
Query: 371 LQL---NFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFA-- 425
+L N+RA QPLN R++ ASF +Q S G++L+L G+L
Sbjct: 256 SKLLVQNYRALQPLNQRMVFASF-------------IQAGSSYTTGEMLSLGVGILVGCL 302
Query: 426 --VTSVAFLVQMRRQHRRGTKGGVSYRPAE 453
+ +V F+ + R+ R + V + A+
Sbjct: 303 CLLLAVYFIARKIRKKRLENRKSVVFTSAQ 332
>gi|4502515 carbonic anhydrase XII isoform 1 precursor [Homo
sapiens]
Length = 354
Score = 201 bits (511), Expect = 1e-51
Identities = 124/338 (36%), Positives = 170/338 (50%), Gaps = 32/338 (9%)
Query: 139 SHWRY---GGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRL 195
S W Y G+ W + P+C G QSP+D+ + + +L PLE G+ L + L
Sbjct: 30 SKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLL 89
Query: 196 RNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRP-GSEHTVEGHRFPAEIHVVH 254
NNGHSV+L LP + + G Y A QLHLHWG P GSEHTV G F AE+H+VH
Sbjct: 90 TNNGHSVKLNLPSDMHIQ-GLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVH 148
Query: 255 L-STAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDI 313
S + A + GLAVLA +E G N +Y+++ S L+ + +G E VPG +I
Sbjct: 149 YNSDLYPDASTASNKSEGLAVLAVLIEMG-SFNPSYDKIFSHLQHVKYKGQEAFVPGFNI 207
Query: 314 SALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLW-----GPGD 368
LLP + Y++Y GSLTTPPC V+WTVF V +S +QL L L+ P
Sbjct: 208 EELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSP 267
Query: 369 SRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFA--- 425
+ NFR Q + R++ SF Q+ C AAG L ++ L A
Sbjct: 268 REMINNFRQVQKFDERLVYTSFS-------------QVQVCTAAGLSLGIILSLALAGIL 314
Query: 426 ----VTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA 459
V V+ + R+ ++G GV Y+PA ET A
Sbjct: 315 GICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEA 352
>gi|45935383 carbonic anhydrase XII isoform 2 precursor [Homo
sapiens]
Length = 343
Score = 197 bits (500), Expect = 2e-50
Identities = 122/331 (36%), Positives = 167/331 (50%), Gaps = 29/331 (8%)
Query: 139 SHWRY---GGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRL 195
S W Y G+ W + P+C G QSP+D+ + + +L PLE G+ L + L
Sbjct: 30 SKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLL 89
Query: 196 RNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRP-GSEHTVEGHRFPAEIHVVH 254
NNGHSV+L LP + + G Y A QLHLHWG P GSEHTV G F AE+H+VH
Sbjct: 90 TNNGHSVKLNLPSDMHIQ-GLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVH 148
Query: 255 L-STAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDI 313
S + A + GLAVLA +E G N +Y+++ S L+ + +G E VPG +I
Sbjct: 149 YNSDLYPDASTASNKSEGLAVLAVLIEMG-SFNPSYDKIFSHLQHVKYKGQEAFVPGFNI 207
Query: 314 SALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLW-----GPGD 368
LLP + Y++Y GSLTTPPC V+WTVF V +S +QL L L+ P
Sbjct: 208 EELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSP 267
Query: 369 SRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFAVTS 428
+ NFR Q + R++ SF G+ S LA IL + V
Sbjct: 268 REMINNFRQVQKFDERLVYTSFSQGIILS------------LALAGILGICI-----VVV 310
Query: 429 VAFLVQMRRQHRRGTKGGVSYRPAEVAETGA 459
V+ + R+ ++G GV Y+PA ET A
Sbjct: 311 VSIWLFRRKSIKKGDNKGVIYKPATKMETEA 341
>gi|70167127 carbonic anhydrase VI precursor [Homo sapiens]
Length = 308
Score = 192 bits (489), Expect = 4e-49
Identities = 103/260 (39%), Positives = 148/260 (56%), Gaps = 8/260 (3%)
Query: 139 SHWRYG----GDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELR 194
S W Y + WP+ PAC G+ QSP++++ + P+L+ L + G++ E
Sbjct: 21 SDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQA-GEFP 79
Query: 195 LRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRP--GSEHTVEGHRFPAEIHV 252
+ NNGH+VQ++LP + M + G Y A Q+H HWG A GSEHTV+G R EIH+
Sbjct: 80 MVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHI 139
Query: 253 VHLSTAFARVDEALGRPGGLAVLAAFLE-EGPEENSAYEQLLSRLEEIAEEGSETQVPGL 311
VH ++ + D A P GLAVLAAF+E + EN+ Y +S L I G T + GL
Sbjct: 140 VHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGL 199
Query: 312 DISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRL 371
D+ +LP + Y+ Y GSLTTPPC + V W V V LS Q+ L ++L + +
Sbjct: 200 DVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTI 259
Query: 372 QLNFRATQPLNGRVIEASFP 391
++R TQPLN RV+E++FP
Sbjct: 260 HNDYRRTQPLNHRVVESNFP 279
>gi|4885101 carbonic anhydrase VII isoform 1 [Homo sapiens]
Length = 264
Score = 155 bits (391), Expect = 9e-38
Identities = 96/263 (36%), Positives = 138/263 (52%), Gaps = 16/263 (6%)
Query: 141 WRYG---GDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRN 197
W YG G W ++ P G QSP++I A + P+L+PLEL L + N
Sbjct: 7 WGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLEL---SYEACMSLSITN 63
Query: 198 NGHSVQLTLPPGLEMALGPGRE----YRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVV 253
NGHSVQ+ + + G YR Q H HWG GSEHTV+G FP+E+H+V
Sbjct: 64 NGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLV 123
Query: 254 HLST-AFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLD 312
H + ++ EA P GLAV+ FLE G +E+ + +L L + +G++ Q +
Sbjct: 124 HWNAKKYSTFGEAASAPDGLAVVGVFLETG-DEHPSMNRLTDALYMVRFKGTKAQFSCFN 182
Query: 313 ISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLW-GPGDSRL 371
LLP+ Y+ Y GSLTTPP ++ V W V + + +S +Q+ L+ D R+
Sbjct: 183 PKCLLPAS-RHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERI 241
Query: 372 QL--NFRATQPLNGRVIEASFPA 392
+ NFR QPL GRV++ASF A
Sbjct: 242 HMVNNFRPPQPLKGRVVKASFRA 264
>gi|22027500 carbonic anhydrase VIII [Homo sapiens]
Length = 290
Score = 155 bits (391), Expect = 9e-38
Identities = 98/298 (32%), Positives = 155/298 (52%), Gaps = 26/298 (8%)
Query: 110 LEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQ 169
+ DL +E E + + ++EG + W Y W V P G +QSP+++ +
Sbjct: 1 MADLSFIEDTVAFPEKEEDEEEEEEGVE---WGYEEGVEWGLVFPDANGEYQSPINLNSR 57
Query: 170 LAAFCPALRPLELLGFQLPP----LPELRLRNNGHSVQLTLPPGLEMALGP---GREYRA 222
A + P+L L +L P + + N+GH++Q+ L ++ GP G E+
Sbjct: 58 EARYDPSL-----LDVRLSPNYVVCRDCEVTNDGHTIQVILKSKSVLSGGPLPQGHEFEL 112
Query: 223 LQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHL-STAFARVDEALGRPGGLAVLAAFLEE 281
++ HWG + GSEHTV FP E+H++H ST F +DEA+G+P G+A++A F++
Sbjct: 113 YEVRFHWGRENQRGSEHTVNFKAFPMELHLIHWNSTLFGSIDEAVGKPHGIAIIALFVQI 172
Query: 282 GPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSR-YFQYEGSLTTPPCAQGV 340
G +E+ + + L++I +G +P + + LLP R Y+ YEGSLT PPC++GV
Sbjct: 173 G-KEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVYEGSLTIPPCSEGV 231
Query: 341 IWTVFNQTVMLSAKQL--------HTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASF 390
W +F + +S Q+ H L D L NFR TQPL+ RVI A+F
Sbjct: 232 TWILFRYPLTISQLQIEEFRRLRTHVKGAELVEGCDGILGDNFRPTQPLSDRVIRAAF 289
>gi|4557395 carbonic anhydrase II [Homo sapiens]
Length = 260
Score = 145 bits (365), Expect = 1e-34
Identities = 90/261 (34%), Positives = 132/261 (50%), Gaps = 15/261 (5%)
Query: 140 HWRYG---GDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLR 196
HW YG G W + P G QSPVDI A + P+L+PL + Q LR+
Sbjct: 4 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQAT---SLRIL 60
Query: 197 NNGHSVQLTLPPGLEMALGPGRE----YRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHV 252
NNGH+ + + A+ G YR +Q H HWG+ GSEHTV+ ++ AE+H+
Sbjct: 61 NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL 120
Query: 253 VHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLD 312
VH +T + +A+ +P GLAVL FL+ G ++++ L+ I +G D
Sbjct: 121 VHWNTKYGDFGKAVQQPDGLAVLGIFLKVG-SAKPGLQKVVDVLDSIKTKGKSADFTNFD 179
Query: 313 ISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQL---HTLSDTLWGPGDS 369
LLP Y+ Y GSLTTPP + V W V + + +S++Q+ L+ G +
Sbjct: 180 PRGLLPESLD-YWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEE 238
Query: 370 RLQLNFRATQPLNGRVIEASF 390
+ N+R QPL R I+ASF
Sbjct: 239 LMVDNWRPAQPLKNRQIKASF 259
>gi|38348436 carbonic anhydrase XIII [Homo sapiens]
Length = 262
Score = 143 bits (360), Expect = 4e-34
Identities = 92/256 (35%), Positives = 132/256 (51%), Gaps = 13/256 (5%)
Query: 143 YGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSV 202
+ G W P G QSP++I+ + + +LRPL + + P + N+GHS
Sbjct: 11 HNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSI---KYDPSSAKIISNSGHSF 67
Query: 203 QLTLPPGLEMALGPGR----EYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHL-ST 257
+ ++ G YR Q+HLHWG+A GSEH V+G + AE+HVVH S
Sbjct: 68 NVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSD 127
Query: 258 AFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALL 317
+ EA P GLAVL FL+ G E NS +++ L+ I E+G +T+ D+ +LL
Sbjct: 128 KYPSFVEAAHEPDGLAVLGVFLQIG-EPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLL 186
Query: 318 PSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQL---HTLSDTLWGPGDSRLQLN 374
P + Y+ Y GSLT PP + V W V Q + +S++QL +L T G + L N
Sbjct: 187 PPSWD-YWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSN 245
Query: 375 FRATQPLNGRVIEASF 390
R QPL GR + ASF
Sbjct: 246 HRPPQPLKGRKVRASF 261
>gi|192447434 carbonic anhydrase I [Homo sapiens]
Length = 261
Score = 136 bits (343), Expect = 3e-32
Identities = 86/261 (32%), Positives = 131/261 (50%), Gaps = 16/261 (6%)
Query: 141 WRY---GGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRN 197
W Y G W ++ P G QSPVDI+ +L+P+ + P + N
Sbjct: 6 WGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISV---SYNPATAKEIIN 62
Query: 198 NGHSVQLTLPPGLEMAL---GPGRE-YRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVV 253
GHS + ++ GP + YR Q H HWG+ GSEHTV+G ++ AE+HV
Sbjct: 63 VGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVA 122
Query: 254 HLSTA-FARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLD 312
H ++A ++ + EA + GLAV+ ++ G E N +++L L+ I +G D
Sbjct: 123 HWNSAKYSSLAEAASKADGLAVIGVLMKVG-EANPKLQKVLDALQAIKTKGKRAPFTNFD 181
Query: 313 ISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQL---HTLSDTLWGPGDS 369
S LLPS ++ Y GSLT PP + V W + +++ +S++QL +L + G
Sbjct: 182 PSTLLPSSLD-FWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV 240
Query: 370 RLQLNFRATQPLNGRVIEASF 390
+Q N R TQPL GR + ASF
Sbjct: 241 PMQHNNRPTQPLKGRTVRASF 261
>gi|192447432 carbonic anhydrase I [Homo sapiens]
Length = 261
Score = 136 bits (343), Expect = 3e-32
Identities = 86/261 (32%), Positives = 131/261 (50%), Gaps = 16/261 (6%)
Query: 141 WRY---GGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRN 197
W Y G W ++ P G QSPVDI+ +L+P+ + P + N
Sbjct: 6 WGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISV---SYNPATAKEIIN 62
Query: 198 NGHSVQLTLPPGLEMAL---GPGRE-YRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVV 253
GHS + ++ GP + YR Q H HWG+ GSEHTV+G ++ AE+HV
Sbjct: 63 VGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVA 122
Query: 254 HLSTA-FARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLD 312
H ++A ++ + EA + GLAV+ ++ G E N +++L L+ I +G D
Sbjct: 123 HWNSAKYSSLAEAASKADGLAVIGVLMKVG-EANPKLQKVLDALQAIKTKGKRAPFTNFD 181
Query: 313 ISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQL---HTLSDTLWGPGDS 369
S LLPS ++ Y GSLT PP + V W + +++ +S++QL +L + G
Sbjct: 182 PSTLLPSSLD-FWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV 240
Query: 370 RLQLNFRATQPLNGRVIEASF 390
+Q N R TQPL GR + ASF
Sbjct: 241 PMQHNNRPTQPLKGRTVRASF 261
>gi|192447430 carbonic anhydrase I [Homo sapiens]
Length = 261
Score = 136 bits (343), Expect = 3e-32
Identities = 86/261 (32%), Positives = 131/261 (50%), Gaps = 16/261 (6%)
Query: 141 WRY---GGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRN 197
W Y G W ++ P G QSPVDI+ +L+P+ + P + N
Sbjct: 6 WGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISV---SYNPATAKEIIN 62
Query: 198 NGHSVQLTLPPGLEMAL---GPGRE-YRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVV 253
GHS + ++ GP + YR Q H HWG+ GSEHTV+G ++ AE+HV
Sbjct: 63 VGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVA 122
Query: 254 HLSTA-FARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLD 312
H ++A ++ + EA + GLAV+ ++ G E N +++L L+ I +G D
Sbjct: 123 HWNSAKYSSLAEAASKADGLAVIGVLMKVG-EANPKLQKVLDALQAIKTKGKRAPFTNFD 181
Query: 313 ISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQL---HTLSDTLWGPGDS 369
S LLPS ++ Y GSLT PP + V W + +++ +S++QL +L + G
Sbjct: 182 PSTLLPSSLD-FWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV 240
Query: 370 RLQLNFRATQPLNGRVIEASF 390
+Q N R TQPL GR + ASF
Sbjct: 241 PMQHNNRPTQPLKGRTVRASF 261
>gi|4502517 carbonic anhydrase I [Homo sapiens]
Length = 261
Score = 136 bits (343), Expect = 3e-32
Identities = 86/261 (32%), Positives = 131/261 (50%), Gaps = 16/261 (6%)
Query: 141 WRY---GGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRN 197
W Y G W ++ P G QSPVDI+ +L+P+ + P + N
Sbjct: 6 WGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISV---SYNPATAKEIIN 62
Query: 198 NGHSVQLTLPPGLEMAL---GPGRE-YRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVV 253
GHS + ++ GP + YR Q H HWG+ GSEHTV+G ++ AE+HV
Sbjct: 63 VGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVA 122
Query: 254 HLSTA-FARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLD 312
H ++A ++ + EA + GLAV+ ++ G E N +++L L+ I +G D
Sbjct: 123 HWNSAKYSSLAEAASKADGLAVIGVLMKVG-EANPKLQKVLDALQAIKTKGKRAPFTNFD 181
Query: 313 ISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQL---HTLSDTLWGPGDS 369
S LLPS ++ Y GSLT PP + V W + +++ +S++QL +L + G
Sbjct: 182 PSTLLPSSLD-FWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV 240
Query: 370 RLQLNFRATQPLNGRVIEASF 390
+Q N R TQPL GR + ASF
Sbjct: 241 PMQHNNRPTQPLKGRTVRASF 261
>gi|62240989 carbonic anhydrase VII isoform 2 [Homo sapiens]
Length = 208
Score = 130 bits (328), Expect = 2e-30
Identities = 78/208 (37%), Positives = 113/208 (54%), Gaps = 10/208 (4%)
Query: 193 LRLRNNGHSVQLTLPPGLEMALGPGRE----YRALQLHLHWGAAGRPGSEHTVEGHRFPA 248
L + NNGHSVQ+ + + G YR Q H HWG GSEHTV+G FP+
Sbjct: 3 LSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPS 62
Query: 249 EIHVVHLST-AFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQ 307
E+H+VH + ++ EA P GLAV+ FLE G +E+ + +L L + +G++ Q
Sbjct: 63 ELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETG-DEHPSMNRLTDALYMVRFKGTKAQ 121
Query: 308 VPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLW-GP 366
+ LLP+ Y+ Y GSLTTPP ++ V W V + + +S +Q+ L+
Sbjct: 122 FSCFNPKCLLPAS-RHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSE 180
Query: 367 GDSRLQL--NFRATQPLNGRVIEASFPA 392
D R+ + NFR QPL GRV++ASF A
Sbjct: 181 DDERIHMVNNFRPPQPLKGRVVKASFRA 208
>gi|4885099 carbonic anhydrase III [Homo sapiens]
Length = 260
Score = 130 bits (327), Expect = 2e-30
Identities = 80/255 (31%), Positives = 129/255 (50%), Gaps = 12/255 (4%)
Query: 143 YGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSV 202
+ G W + P G QSPV++ + P+L+P + + NNG +
Sbjct: 10 HNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSV---SYDGGSAKTILNNGKTC 66
Query: 203 QLTLPPGLEMALGPGRE----YRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTA 258
++ + ++ G YR Q HLHWG++ GSEHTV+G ++ AE+H+VH +
Sbjct: 67 RVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPK 126
Query: 259 FARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLP 318
+ EAL + G+AV+ FL+ G EN ++ L L++I +G E D S L P
Sbjct: 127 YNTFKEALKQRDGIAVIGIFLKIG-HENGEFQIFLDALDKIKTKGKEAPFTKFDPSCLFP 185
Query: 319 SDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDS---RLQLNF 375
+ Y+ Y+GS TTPPC + ++W + + + +S+ Q+ L L + L N+
Sbjct: 186 A-CRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSNW 244
Query: 376 RATQPLNGRVIEASF 390
R QP+N RV+ ASF
Sbjct: 245 RPPQPINNRVVRASF 259
>gi|6005723 carbonic anhydrase VB, mitochondrial precursor [Homo
sapiens]
Length = 317
Score = 130 bits (326), Expect = 3e-30
Identities = 86/252 (34%), Positives = 126/252 (50%), Gaps = 13/252 (5%)
Query: 147 PPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTL 206
P W V G QSP++IR + + + P L+PL + P L + NNG+S +
Sbjct: 50 PLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTI---SYDPATCLHVWNNGYSFLVEF 106
Query: 207 PPGLEMALGPG----REYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTA-FAR 261
+ ++ G YR Q H HWGA GSEHTV+ FPAE+H+VH + F
Sbjct: 107 EDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFEN 166
Query: 262 VDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDF 321
++A GLAV+ FL+ G + + ++L+ L I + + + D S L+P+
Sbjct: 167 FEDAALEENGLAVIGVFLKLG-KHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPT-C 224
Query: 322 SRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQL---HTLSDTLWGPGDSRLQLNFRAT 378
Y+ Y GSLTTPP ++ V W + Q V + QL TL T G + R+ NFR
Sbjct: 225 PDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPL 284
Query: 379 QPLNGRVIEASF 390
QPL R + +SF
Sbjct: 285 QPLMNRTVRSSF 296
>gi|4502521 carbonic anhydrase VA, mitochondrial precursor [Homo
sapiens]
Length = 305
Score = 125 bits (314), Expect = 8e-29
Identities = 86/254 (33%), Positives = 127/254 (50%), Gaps = 13/254 (5%)
Query: 147 PPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTL 206
P W G QSP++I+ + + + P L+PL + L + N G+ Q+
Sbjct: 50 PLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRV---SYEAASCLYIWNTGYLFQVEF 106
Query: 207 PPGLE---MALGP-GREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHL-STAFAR 261
E ++ GP YR Q H HWGA GSEHTV+GH +PAE+H+VH S +
Sbjct: 107 DDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQN 166
Query: 262 VDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDF 321
EA+ GLAV+ FL+ G + ++L+ L EI + + + D S LLP+ +
Sbjct: 167 YKEAVVGENGLAVIGVFLKLG-AHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCW 225
Query: 322 SRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQL---HTLSDTLWGPGDSRLQLNFRAT 378
Y+ Y GSLTTPP + V W + + V ++ QL TL + G + + N+R
Sbjct: 226 D-YWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPL 284
Query: 379 QPLNGRVIEASFPA 392
QPL R + ASF A
Sbjct: 285 QPLMNRKVWASFQA 298
>gi|194097398 protein tyrosine phosphatase, receptor type, G
precursor [Homo sapiens]
Length = 1445
Score = 124 bits (312), Expect = 1e-28
Identities = 82/272 (30%), Positives = 128/272 (47%), Gaps = 14/272 (5%)
Query: 131 RDKEGDDQSHWRYGG---DPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQL 187
R ++ +W Y G W S +C GR QSP+DI Q A + L+L GF
Sbjct: 50 RRRKASGDPYWAYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDN 109
Query: 188 PPLPELRLRNNGHSVQLTLPPGLEMALG--PGREYRALQLHLHWGAA-GRPGSEHTVEGH 244
+ ++N G +V + L ++ PGR ++A ++ HWG + G GSEH++ G
Sbjct: 110 ESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGR-FKAEKVEFHWGHSNGSAGSEHSINGR 168
Query: 245 RFPAEIHVVHLSTA-FARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEG 303
RFP E+ + + F A+ + +A F + P +NSA + ++ L+ +
Sbjct: 169 RFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHE 228
Query: 304 SETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTL 363
ET + + LLP+ Y++Y GSLTTPPC++ V W VF + V +S QL
Sbjct: 229 KETFLDPFVLRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIF 288
Query: 364 WGPGDSR------LQLNFRATQPLNGRVIEAS 389
L+ NFR Q L+ RV+ S
Sbjct: 289 TTEQQDHVKSVEYLRNNFRPQQRLHDRVVSKS 320
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 115 bits (288), Expect = 8e-26
Identities = 76/263 (28%), Positives = 120/263 (45%), Gaps = 13/263 (4%)
Query: 141 WRYGG---DPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRN 197
W Y G W + P C QSP++I L L+ L+ G+ L + N
Sbjct: 38 WSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHN 97
Query: 198 NGHSVQLTLPPGLEMALGPGRE-YRALQLHLHWGAAGRP--GSEHTVEGHRFPAEIHVVH 254
G +V++ L ++ G ++A ++ HWG GSEH++EG +FP E+ +
Sbjct: 98 TGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYC 157
Query: 255 LST-AFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDI 313
F+ +EA+ G L L+ E G EEN ++ ++ +E ++ G + + +
Sbjct: 158 FDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFIL 217
Query: 314 SALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGD----- 368
LLP+ +Y+ Y GSLT+PPC V W VF TV +S QL + L
Sbjct: 218 LNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVML 277
Query: 369 -SRLQLNFRATQPLNGRVIEASF 390
LQ NFR Q R + +S+
Sbjct: 278 MDYLQNNFREQQYKFSRQVFSSY 300
>gi|4502519 carbonic anhydrase IV precursor [Homo sapiens]
Length = 312
Score = 111 bits (277), Expect = 2e-24
Identities = 83/271 (30%), Positives = 122/271 (45%), Gaps = 17/271 (6%)
Query: 138 QSHWRY---GGDPPWPRVSPA-----CAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPP 189
+SHW Y +P + P C QSP++I A L G+
Sbjct: 20 ESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQ 79
Query: 190 LPELRLRNNGHSVQLTLPPGLEMALGP-GREYRALQLHLHWGAAGRPGSEHTVEGHRFPA 248
++NNGHSV + L ++ G Y+A QLHLHW GSEH+++G F
Sbjct: 80 T--WTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAM 137
Query: 249 EIHVVHLST--AFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSET 306
E+H+VH V EA +AVLA +E G + N ++ L+ L I + T
Sbjct: 138 EMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMST 197
Query: 307 QVPGLDISALLPSD--FSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLW 364
+ + LLP + YF+Y GSLTTP C + V+WTVF + + L +Q+ S L+
Sbjct: 198 TMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLY 257
Query: 365 GPGDSRLQL--NFRATQPLNGRVIEASFPAG 393
+ + + N R Q L R + S G
Sbjct: 258 YDKEQTVSMKDNVRPLQQLGQRTVIKSGAPG 288
>gi|130979954 carbonic anhydrase X [Homo sapiens]
Length = 328
Score = 99.0 bits (245), Expect = 8e-21
Identities = 73/244 (29%), Positives = 117/244 (47%), Gaps = 18/244 (7%)
Query: 158 GRFQSPVDIRPQLAAFCPALRPLELL--GFQLPPLPELRLRNNGHSVQLTLPPGLEMALG 215
G+ QSPV+I F P L PL + G ++ + N G V L L + +
Sbjct: 63 GKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGT----MYNTGRHVSLRLDKEHLVNIS 118
Query: 216 PGR---EYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLS-TAFARVDEALGRPGG 271
G +R ++ LH+G+ GSEH + G F E+ ++H + + V EA P G
Sbjct: 119 GGPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNG 178
Query: 272 LAVLAAFLEEGPEENSAYEQLLSR--LEEIAEEGSETQVPGLDISALLPSDFSRYFQYEG 329
L V++ F++ N ++L+R + I + + GL+I L P + S + Y+G
Sbjct: 179 LVVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYP-ETSSFITYDG 237
Query: 330 SLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQL----NFRATQPLNGRV 385
S+T PPC + W + N+ V ++ Q+H+L L S++ L NFR QPLN R
Sbjct: 238 SMTIPPCYETASWIIMNKPVYITRMQMHSLR-LLSQNQPSQIFLSMSDNFRPVQPLNNRC 296
Query: 386 IEAS 389
I +
Sbjct: 297 IRTN 300
>gi|130979679 carbonic anhydrase X [Homo sapiens]
Length = 328
Score = 99.0 bits (245), Expect = 8e-21
Identities = 73/244 (29%), Positives = 117/244 (47%), Gaps = 18/244 (7%)
Query: 158 GRFQSPVDIRPQLAAFCPALRPLELL--GFQLPPLPELRLRNNGHSVQLTLPPGLEMALG 215
G+ QSPV+I F P L PL + G ++ + N G V L L + +
Sbjct: 63 GKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGT----MYNTGRHVSLRLDKEHLVNIS 118
Query: 216 PGR---EYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLS-TAFARVDEALGRPGG 271
G +R ++ LH+G+ GSEH + G F E+ ++H + + V EA P G
Sbjct: 119 GGPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNG 178
Query: 272 LAVLAAFLEEGPEENSAYEQLLSR--LEEIAEEGSETQVPGLDISALLPSDFSRYFQYEG 329
L V++ F++ N ++L+R + I + + GL+I L P + S + Y+G
Sbjct: 179 LVVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYP-ETSSFITYDG 237
Query: 330 SLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQL----NFRATQPLNGRV 385
S+T PPC + W + N+ V ++ Q+H+L L S++ L NFR QPLN R
Sbjct: 238 SMTIPPCYETASWIIMNKPVYITRMQMHSLR-LLSQNQPSQIFLSMSDNFRPVQPLNNRC 296
Query: 386 IEAS 389
I +
Sbjct: 297 IRTN 300
>gi|9910366 carbonic anhydrase X [Homo sapiens]
Length = 328
Score = 99.0 bits (245), Expect = 8e-21
Identities = 73/244 (29%), Positives = 117/244 (47%), Gaps = 18/244 (7%)
Query: 158 GRFQSPVDIRPQLAAFCPALRPLELL--GFQLPPLPELRLRNNGHSVQLTLPPGLEMALG 215
G+ QSPV+I F P L PL + G ++ + N G V L L + +
Sbjct: 63 GKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGT----MYNTGRHVSLRLDKEHLVNIS 118
Query: 216 PGR---EYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLS-TAFARVDEALGRPGG 271
G +R ++ LH+G+ GSEH + G F E+ ++H + + V EA P G
Sbjct: 119 GGPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNG 178
Query: 272 LAVLAAFLEEGPEENSAYEQLLSR--LEEIAEEGSETQVPGLDISALLPSDFSRYFQYEG 329
L V++ F++ N ++L+R + I + + GL+I L P + S + Y+G
Sbjct: 179 LVVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYP-ETSSFITYDG 237
Query: 330 SLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQL----NFRATQPLNGRV 385
S+T PPC + W + N+ V ++ Q+H+L L S++ L NFR QPLN R
Sbjct: 238 SMTIPPCYETASWIIMNKPVYITRMQMHSLR-LLSQNQPSQIFLSMSDNFRPVQPLNNRC 296
Query: 386 IEAS 389
I +
Sbjct: 297 IRTN 300
>gi|9951923 carbonic anhydrase XI precursor [Homo sapiens]
Length = 328
Score = 94.7 bits (234), Expect = 2e-19
Identities = 81/285 (28%), Positives = 125/285 (43%), Gaps = 29/285 (10%)
Query: 129 AHRDKEGDDQSHWRYG---------GDPPWPRVSPA---CA-GRFQSPVDIRPQLAAFCP 175
AH D + W Y G P W V+ A CA G+ QSPVD+ + + P
Sbjct: 23 AHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSLCAVGKRQSPVDVELKRVLYDP 82
Query: 176 ALRPLELL--GFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGR---EYRALQLHLHWG 230
L PL L G +L L N G V P + + G +R +L L +G
Sbjct: 83 FLPPLRLSTGGEKLRGT----LYNTGRHVSFLPAPRPVVNVSGGPLLYSHRLSELRLLFG 138
Query: 231 AAGRPGSEHTVEGHRFPAEIHVVHLSTA-FARVDEALGRPGGLAVLAAFLEEGPEENSAY 289
A GSEH + F AE+ ++H + + A P GLA+L+ F+ N
Sbjct: 139 ARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGLAILSLFVNVASTSNPFL 198
Query: 290 EQLLSR--LEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQ 347
+LL+R + I+ + + L + L P F + Y+GSL+TPPC++ V W + ++
Sbjct: 199 SRLLNRDTITRISYKNDAYFLQDLSLELLFPESFG-FITYQGSLSTPPCSETVTWILIDR 257
Query: 348 TVMLSAKQLHTLSDTLWGPGDSRLQL---NFRATQPLNGRVIEAS 389
+ +++ Q+H+L P Q N R QPL R + +
Sbjct: 258 ALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALRGN 302
>gi|239756368 PREDICTED: similar to acidic (leucine-rich) nuclear
phosphoprotein 32 family, member B [Homo sapiens]
Length = 272
Score = 50.1 bits (118), Expect = 4e-06
Identities = 34/115 (29%), Positives = 54/115 (46%), Gaps = 2/115 (1%)
Query: 24 QLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDL 83
+LL L L P+ D+ + G E+D GE++ E + EE+ EED
Sbjct: 157 KLLPQLTCLDTYDPEDQEAPDSDAQVDGVDKEEEDEEGEDEKDXENEDGEEEELDEEED- 215
Query: 84 PGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQ 138
+ED+ G++D EV + EE G K ED + + +E +R +E DD+
Sbjct: 216 -EDEDVEGDDDKDEVSEEEEEFGLDKDEDDEDEDEDEEEEESGKGENRKRETDDE 269
>gi|239750893 PREDICTED: similar to acidic (leucine-rich) nuclear
phosphoprotein 32 family, member B [Homo sapiens]
Length = 272
Score = 50.1 bits (118), Expect = 4e-06
Identities = 34/115 (29%), Positives = 54/115 (46%), Gaps = 2/115 (1%)
Query: 24 QLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDL 83
+LL L L P+ D+ + G E+D GE++ E + EE+ EED
Sbjct: 157 KLLPQLTCLDTYDPEDQEAPDSDAQVDGVDKEEEDEEGEDEKDXENEDGEEEELDEEED- 215
Query: 84 PGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQ 138
+ED+ G++D EV + EE G K ED + + +E +R +E DD+
Sbjct: 216 -EDEDVEGDDDKDEVSEEEEEFGLDKDEDDEDEDEDEEEEESGKGENRKRETDDE 269
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 47.0 bits (110), Expect = 4e-05
Identities = 27/74 (36%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 53 SSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLP-EVKPKSEEEGSLKLE 111
+S E+ P E P E++P E PP E+ P E P E+ P EV+P EE +++
Sbjct: 601 ASAEEAP-AEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQ 659
Query: 112 DLPTVEAPGDPQEP 125
P EAP + Q P
Sbjct: 660 PPPAEEAPAEVQPP 673
Score = 42.7 bits (99), Expect = 7e-04
Identities = 26/75 (34%), Positives = 37/75 (49%), Gaps = 7/75 (9%)
Query: 56 EDDPLGEEDLPSE------EDSPREEDPPGEEDLPGEEDLPGEEDLP-EVKPKSEEEGSL 108
E P E+ P+E E++P E PP E+ P E P E+ P EV+P EE
Sbjct: 609 EVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPA 668
Query: 109 KLEDLPTVEAPGDPQ 123
+++ P EAP + Q
Sbjct: 669 EVQPPPAEEAPAEVQ 683
Score = 42.7 bits (99), Expect = 7e-04
Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 1/80 (1%)
Query: 41 PRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGE-EDLPGEEDLPEVK 99
P E++P ++ E P E++P E PP E+ P E + P EE EV+
Sbjct: 612 PPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQ 671
Query: 100 PKSEEEGSLKLEDLPTVEAP 119
P EE +++ LP E P
Sbjct: 672 PPPAEEAPAEVQSLPAEETP 691
Score = 39.3 bits (90), Expect = 0.008
Identities = 30/98 (30%), Positives = 42/98 (42%), Gaps = 17/98 (17%)
Query: 44 QEDSPLGGGSSGEDDPLGEEDLPSE-----EDSPREEDPPGEEDLPGEE----------- 87
+ SPL +S E+ P E PS E++P E PP E+ EE
Sbjct: 541 EAQSPLSEETSAEEAP-AEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQLLAAT 599
Query: 88 DLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEP 125
+ EE EV+P EE +++ P EAP + Q P
Sbjct: 600 EASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPP 637
Score = 38.1 bits (87), Expect = 0.017
Identities = 28/94 (29%), Positives = 40/94 (42%), Gaps = 2/94 (2%)
Query: 41 PRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLP-EVK 99
P E++P ++ E P E++P E PP E+ P E P E+ P EV+
Sbjct: 624 PPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQ 683
Query: 100 PKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDK 133
EE ++ E L V +P P A DK
Sbjct: 684 SLPAEETPIE-ETLAAVHSPPADDVPAEEASVDK 716
Score = 36.6 bits (83), Expect = 0.049
Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 9/80 (11%)
Query: 54 SGEDDP----LGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLK 109
S E+ P L E PS E+SP EE PP E P E P E L E++ S ++ ++
Sbjct: 337 SAEESPSVELLAEILPPSAEESPSEE-PPAEILPPPAEKSPSVELLGEIRSPSAQKAPIE 395
Query: 110 LEDLPT----VEAPGDPQEP 125
++ LP EAP + P
Sbjct: 396 VQPLPAEGALEEAPAKVEPP 415
Score = 35.8 bits (81), Expect = 0.083
Identities = 32/103 (31%), Positives = 47/103 (45%), Gaps = 23/103 (22%)
Query: 40 LPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGE-EDLPGEEDLPEV 98
+P +QE S + +S E +P PS E P + PP E+ + E P EE +V
Sbjct: 240 VPVVQEGSAVKKVASAEIEP------PSTEKFPAKIQPPLVEEATAKAEPRPAEETHVQV 293
Query: 99 KPKSEE-----------EGSLKL-----EDLPTVEAPGDPQEP 125
+P +EE E S+K+ E+ P VE P + Q P
Sbjct: 294 QPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPP 336
Score = 31.6 bits (70), Expect = 1.6
Identities = 20/74 (27%), Positives = 34/74 (45%), Gaps = 3/74 (4%)
Query: 66 PSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGD--PQ 123
P +++P E P E+ EE E P + + EE S +++ L +EAP D P
Sbjct: 482 PPADETPAEARSPLSEETSAEE-AHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPA 540
Query: 124 EPQNNAHRDKEGDD 137
E Q+ + ++
Sbjct: 541 EAQSPLSEETSAEE 554
Score = 30.8 bits (68), Expect = 2.7
Identities = 25/71 (35%), Positives = 31/71 (43%), Gaps = 9/71 (12%)
Query: 56 EDDPLGEEDLPSEEDSPREEDPPGE-EDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLP 114
E P E+ P+E P E+ P E + LP EE P EE L V S +D+P
Sbjct: 657 EVQPPPAEEAPAEVQPPPAEEAPAEVQSLPAEE-TPIEETLAAVH-------SPPADDVP 708
Query: 115 TVEAPGDPQEP 125
EA D P
Sbjct: 709 AEEASVDKHSP 719
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 46.6 bits (109), Expect = 5e-05
Identities = 27/46 (58%), Positives = 32/46 (69%), Gaps = 3/46 (6%)
Query: 59 PLGEEDLPSEEDSPREED--PPGEEDLPGEED-LPGEEDLPEVKPK 101
P EE LP EE+ P EE+ PP EE +P EE+ +P EE LPEVKPK
Sbjct: 10135 PEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPK 10180
Score = 44.7 bits (104), Expect = 2e-04
Identities = 37/98 (37%), Positives = 53/98 (54%), Gaps = 13/98 (13%)
Query: 33 VPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDL-PSEEDSPREED--PPGEEDLPGEED- 88
V P ++P+ +E P+ E++ L EE++ P EE P EE+ P EE LP EE+
Sbjct: 10081 VEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEV 10140
Query: 89 LPGEEDLP----EVKPK-----SEEEGSLKLEDLPTVE 117
LP EE++P EV P+ EEE + E LP V+
Sbjct: 10141 LPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVK 10178
Score = 33.9 bits (76), Expect = 0.32
Identities = 35/124 (28%), Positives = 52/124 (41%), Gaps = 23/124 (18%)
Query: 8 PWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPS 67
P P PA P + +++ + VP P+ P + P P+ EE P+
Sbjct: 10739 PKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVP--------KKPVLEEK-PA 10789
Query: 68 EEDSPREEDPPGE-----EDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDP 122
R E PP E E++ EE++ EE+ P P +EEE P V P P
Sbjct: 10790 VPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKP--VPVAEEEE-------PEVPPPAVP 10840
Query: 123 QEPQ 126
+EP+
Sbjct: 10841 EEPK 10844
Score = 30.8 bits (68), Expect = 2.7
Identities = 32/123 (26%), Positives = 55/123 (44%), Gaps = 31/123 (25%)
Query: 14 IPAPAPGLTVQLLLSLLLL----------VPVHPQR-------LPRMQEDSPLGGGSSGE 56
+PAP P + ++ +++ VP P++ LP+ +E P+ E
Sbjct: 10183 VPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPE 10242
Query: 57 DDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTV 116
++P+ EE++P E+PP E++ EE P +PEV K+ E + V
Sbjct: 10243 EEPISEEEIP--------EEPPSIEEV--EEVAPPR--VPEVIKKAVPEAPTPVP--KKV 10288
Query: 117 EAP 119
EAP
Sbjct: 10289 EAP 10291
Score = 29.6 bits (65), Expect = 6.0
Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 6/72 (8%)
Query: 59 PLGEEDLPSEEDSPRE---EDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGS---LKLED 112
P E P + P E E+PP E E P + +P KP E++ K +
Sbjct: 10656 PKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPE 10715
Query: 113 LPTVEAPGDPQE 124
LP V+ P P+E
Sbjct: 10716 LPPVKVPEVPKE 10727
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 45.4 bits (106), Expect = 1e-04
Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 22/120 (18%)
Query: 37 PQRLPRMQED-SPLGGGSSGEDDPLGEEDL--PSEEDSPREEDPPGEEDLPGEEDLPG-- 91
PQ R +E +P+ +S + P E+DL P EE+ EE+ EE+ GEE+ G
Sbjct: 1320 PQEENRREETCAPVSPNTSPGEKP--EDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGN 1377
Query: 92 -----------EEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSH 140
E++ PE+ +E+E S +L+D E + +EP +N D + +D SH
Sbjct: 1378 VEKDPDGAKSQEKEEPEIS--TEKEDSARLDD--HEEEEEEDEEPSHNEDHDADDEDDSH 1433
>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
isoform 1 [Homo sapiens]
Length = 1112
Score = 45.1 bits (105), Expect = 1e-04
Identities = 30/110 (27%), Positives = 45/110 (40%), Gaps = 12/110 (10%)
Query: 58 DPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVE 117
+ + E LPS+ED DP D+ ++ L E LP K ++ E +D+P VE
Sbjct: 688 EEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVE 747
Query: 118 APGDPQEPQNNAHRDKEGD------------DQSHWRYGGDPPWPRVSPA 155
+ + H++KE D D W PP P +PA
Sbjct: 748 KKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPA 797
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.136 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,846,329
Number of Sequences: 37866
Number of extensions: 1403365
Number of successful extensions: 11155
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 188
Number of HSP's successfully gapped in prelim test: 373
Number of HSP's that attempted gapping in prelim test: 5719
Number of HSP's gapped (non-prelim): 3776
length of query: 459
length of database: 18,247,518
effective HSP length: 106
effective length of query: 353
effective length of database: 14,233,722
effective search space: 5024503866
effective search space used: 5024503866
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.