Guide to the Human Genome
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Name: TOP1 Sequence: fasta or formatted (765aa) NCBI GI: 11225260
Description:

DNA topoisomerase I

Referenced in:

Additional Interaction Domain Families
polyADP-Ribose Polymerase Family
Replication Proteins

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             5.2         40           1
 C cysteine            1.0          8           2
 D aspartate           7.5         57           2
 E glutamate          11.1         85           4
 F phenylalanine       3.4         26           2
 G glycine             3.4         26           1
 H histidine           3.1         24           1
 I isoleucine          4.7         36           3
 K lysine             17.5        134           4
 L leucine             6.1         47           2
 M methionine          2.5         19           2
 N asparagine          4.7         36           1
 P proline             4.8         37           3
 Q glutamine           3.4         26           3
 R arginine            5.5         42           2
 S serine              4.1         31           2
 T threonine           3.5         27           2
 V valine              3.9         30           2
 W tryptophan          1.7         13           2
 Y tyrosine            2.7         21           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   DNA topoisomerase I 
TOP1MT                0.540   mitochondrial topoisomerase I 
TAF3                  0.038   RNA polymerase II transcription factor TAFII140 [Ho...
SFRS12                0.037   splicing factor, arginine/serine-rich 12 isoform a ...
SFRS12                0.037   splicing factor, arginine/serine-rich 12 isoform b [...
LOC100131202          0.036   PREDICTED: hypothetical protein 
LOC100133599          0.035   PREDICTED: hypothetical protein 
LOC100133599          0.035   PREDICTED: hypothetical protein 
LOC100286959          0.034   PREDICTED: hypothetical protein XP_002343921 
CYLC2                 0.034   cylicin 2 
RBM25                 0.032   RNA binding motif protein 25 
LOC100131202          0.030   PREDICTED: hypothetical protein 
LOC283685             0.029   PREDICTED: golgi autoantigen, golgin subfamily a-li...
ZC3H13                0.029   zinc finger CCCH-type containing 13 
DDX23                 0.028   DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 
LOC100288837          0.028   PREDICTED: hypothetical protein XP_002343931, parti...
ANKRD12               0.028   ankyrin repeat domain 12 isoform 2 
ANKRD12               0.028   ankyrin repeat domain 12 isoform 1 
PRPF38B               0.028   PRP38 pre-mRNA processing factor 38 (yeast) domain ...
CCDC55                0.028   coiled-coil domain containing 55 isoform 1 
LOC283685             0.027   PREDICTED: golgi autoantigen, golgin subfamily a-li...
LOC727832             0.027   golgi autoantigen, golgin subfamily a-like 
LOC100134067          0.026   PREDICTED: hypothetical protein 
SNRNP70               0.026   U1 small nuclear ribonucleoprotein 70 kDa 
LOC440243             0.026   PREDICTED: Putative golgin subfamily A member 6-lik...
LOC283767             0.025   golgi autoantigen, golgin subfamily a-like 
LOC645202             0.025   PREDICTED: hypothetical protein LOC645202 
LOC100294088          0.025   PREDICTED: hypothetical protein, partial 
NEFH                  0.025   neurofilament, heavy polypeptide 200kDa 
CYLC1                 0.025   cylicin, basic protein of sperm head cytoskeleton 1...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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