Search of human proteins with 11181770

Search of human proteins with 11181770

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
sapiens]
         (592 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...  1197   0.0  
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...  1104   0.0  
gi|194018524 solute carrier family 6, member 18 [Homo sapiens]        603   e-172
gi|51468073 solute carrier family 6, member 19 [Homo sapiens]         597   e-170
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...   536   e-152
gi|58219014 solute carrier family 6, member 17 [Homo sapiens]         513   e-145
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...   466   e-131
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...   372   e-103
gi|92859670 solute carrier family 6 (neurotransmitter transporte...   365   e-101
gi|188528618 solute carrier family 6 (neurotransmitter transport...   365   e-101
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         365   e-101
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...   364   e-100
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...   364   e-100
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...   364   e-100
gi|4507043 solute carrier family 6 member 4 [Homo sapiens]            358   1e-98
gi|171184408 solute carrier family 6 (neurotransmitter transport...   354   1e-97
gi|171184406 solute carrier family 6 (neurotransmitter transport...   354   1e-97
gi|171184404 solute carrier family 6 (neurotransmitter transport...   354   1e-97
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...   350   2e-96
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   346   3e-95
gi|134304856 solute carrier family 6, member 7 [Homo sapiens]         342   6e-94
gi|197276623 solute carrier family 6 (neurotransmitter transport...   341   1e-93
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   341   1e-93
gi|21361581 solute carrier family 6 (neurotransmitter transporte...   340   2e-93
gi|4557046 solute carrier family 6 member 2 [Homo sapiens]            335   5e-92
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   326   3e-89
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...   290   2e-78
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   284   2e-76
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   249   7e-66
gi|197276625 solute carrier family 6 (neurotransmitter transport...   140   4e-33

>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score = 1197 bits (3098), Expect = 0.0
 Identities = 592/592 (100%), Positives = 592/592 (100%)

Query: 1   MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60
           MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY
Sbjct: 1   MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60

Query: 61  LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120
           LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP
Sbjct: 61  LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120

Query: 121 LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV 180
           LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV
Sbjct: 121 LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV 180

Query: 181 VYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKA 240
           VYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKA
Sbjct: 181 VYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKA 240

Query: 241 WINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGF 300
           WINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGF
Sbjct: 241 WINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGF 300

Query: 301 KATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSL 360
           KATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSL
Sbjct: 301 KATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSL 360

Query: 361 ESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTD 420
           ESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTD
Sbjct: 361 ESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTD 420

Query: 421 SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAV 480
           SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAV
Sbjct: 421 SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAV 480

Query: 481 CYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWD 540
           CYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWD
Sbjct: 481 CYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWD 540

Query: 541 ASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA 592
           ASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA
Sbjct: 541 ASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA 592


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score = 1104 bits (2855), Expect = 0.0
 Identities = 555/592 (93%), Positives = 555/592 (93%), Gaps = 37/592 (6%)

Query: 1   MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60
           MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY
Sbjct: 1   MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60

Query: 61  LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120
           LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP
Sbjct: 61  LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120

Query: 121 LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV 180
           LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV
Sbjct: 121 LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV 180

Query: 181 VYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKA 240
           VYLCILRGTESTGK                                     IEQLANPKA
Sbjct: 181 VYLCILRGTESTGK-------------------------------------IEQLANPKA 203

Query: 241 WINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGF 300
           WINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGF
Sbjct: 204 WINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGF 263

Query: 301 KATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSL 360
           KATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSL
Sbjct: 264 KATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSL 323

Query: 361 ESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTD 420
           ESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTD
Sbjct: 324 ESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTD 383

Query: 421 SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAV 480
           SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAV
Sbjct: 384 SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAV 443

Query: 481 CYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWD 540
           CYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWD
Sbjct: 444 CYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWD 503

Query: 541 ASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA 592
           ASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA
Sbjct: 504 ASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA 555


>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score =  603 bits (1556), Expect = e-172
 Identities = 281/581 (48%), Positives = 403/581 (69%), Gaps = 7/581 (1%)

Query: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
           RP W N  Q++ +C  +AVGLGN+WRFPYLCQ YGGG+FL+PY+I L+ EG+P+ ++ELA
Sbjct: 18  RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELA 77

Query: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
           +GQR+R+GS+G W  ISPYLSGVG+  V +SF +S+YYN I AW  WYL +SFQ PLPWS
Sbjct: 78  IGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWS 137

Query: 125 VCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLC 184
            CP + N TG+ EEC+ +S+  YFWYR+TLNI+  + ++G +QW   +CL  +W VVY+C
Sbjct: 138 SCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMC 197

Query: 185 ILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWINA 244
           ++RG E+TGKV+YFTA  PY VL I+LIRGLTL GAT GL+Y+FTP +  L NP+ W++A
Sbjct: 198 VIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDA 257

Query: 245 ATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATF 304
           ATQIFFSL L FG  IAFASYN P N+CQK A++++L+N  TS++ASI  FS+ GFKAT 
Sbjct: 258 ATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATN 317

Query: 305 NYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESEL 364
           +YE+CL +  L L N FD  +  ++  +   V  +L + +P + +++   +K C LE  L
Sbjct: 318 DYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQL--PLKACLLEDFL 375

Query: 365 DTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKII 424
           D +  G GLAF+V+TE   +M  + +W++L+F ML  LG+ +M G   A++TPL D  ++
Sbjct: 376 DKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVL 435

Query: 425 SSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVY 484
              +PKEA++GLVCLV       FT+++GNYW +IF+++AA+ +LL++  +E + V YVY
Sbjct: 436 PRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVY 495

Query: 485 GLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQG 544
           G++RF  D+  MTGR  S YW++ W  VSPLL+ ++FV Y+   +    L+Y+AW+    
Sbjct: 496 GMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLL-TIFVAYII-LLFWKPLRYKAWNPKYE 553

Query: 545 QLVTKD---YPAYALAVIGLLVASSTMCIPLAALGTFVQRR 582
              ++    YP +A A   LL     + +P+AAL   + RR
Sbjct: 554 LFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRR 594


>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score =  597 bits (1538), Expect = e-170
 Identities = 269/585 (45%), Positives = 395/585 (67%), Gaps = 6/585 (1%)

Query: 4   ARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLEL 63
           +RP W N  Q++  C+ + VGLGNVWRFPYLCQ +GGG+F++P++I+L++EG+PLLYLE 
Sbjct: 31  SRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEF 90

Query: 64  AVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPW 123
           A+GQR+R+GS+G W +I P L G+G+AS++ SF + +YYN I +W  WYLF+SFQ+PLPW
Sbjct: 91  AIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPW 150

Query: 124 SVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYL 183
           S CPLN N TGY +EC ++S   YFWYR+TLNIS S+ ++G +QW   LCL  AW V+Y+
Sbjct: 151 SDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYM 210

Query: 184 CILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWIN 243
           C +RG E+TGK VY T++LPY VL I+LIRGLTL GATNG++++FTP + +LA P  W++
Sbjct: 211 CTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLD 270

Query: 244 AATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKAT 303
           A  Q+FFS  L FG LI+F+SYN   NNC+K ++IVS+IN FTS++ +IV +S+ GF+AT
Sbjct: 271 AGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRAT 330

Query: 304 FNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESE 363
             Y++C     L L N FDL +G +T  N   ++    ++ P+ Y+++    + C + + 
Sbjct: 331 QRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLV--FQTCDINAF 388

Query: 364 LDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKI 423
           L  AV+GTGLAFIV+TEAI  M +S LWSVL+F ML  LG+ SM GN   ++ PL D ++
Sbjct: 389 LSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRV 448

Query: 424 ISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYV 483
           I    PKE ++GL+CL    IG +FT+ +G YW  + + YA ++ LL+I   E  +V YV
Sbjct: 449 IPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYV 508

Query: 484 YGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQ 543
           YG+ RF  D++ M G   + +W+V W  VSPLL++ +F+F+    + +  L Y  WD   
Sbjct: 509 YGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEV-SQELTYSIWDPGY 567

Query: 544 GQLVTK---DYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKR 585
            +        YP +   V+ ++    ++ IP  A+   ++   ++
Sbjct: 568 EEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQK 612


>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score =  536 bits (1380), Expect = e-152
 Identities = 268/601 (44%), Positives = 390/601 (64%), Gaps = 35/601 (5%)

Query: 1   MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60
           +E  RP W + LQ++ A + ++VGLGNVWRFPYLCQ  GGG++L+PY+I+L+V G+PL +
Sbjct: 57  VEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFF 116

Query: 61  LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120
           LEL+VGQR+R+GSIG W  ISP L G+G AS VV +F+++YYNVI  W+ +Y   SFQ P
Sbjct: 117 LELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQP 176

Query: 121 LPWSVCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAW 178
           LPW  CPL  N +HT  + ECE++S+T Y+WYR+ LNIS S+ E+GG+ W+  +CLL AW
Sbjct: 177 LPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAW 236

Query: 179 LVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANP 238
           ++V L +++G +S+GK++YF++  PY VLI +LIR   L+G+ +G+ +MFTPK+E +  P
Sbjct: 237 VMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEP 296

Query: 239 KAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIY 298
           K W  AATQ+FF+LGLGFG +IAF+SYN+  NNC   A++VS IN FTS+ A++V F++ 
Sbjct: 297 KVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVL 356

Query: 299 GFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQ--------VKGYLASAYPSKY-- 348
           GFKA    E C+ + S  +         FL   N+ Q        +    A  Y   Y  
Sbjct: 357 GFKANVINEKCITQNSETIMK-------FLKMGNISQDIIPHHINLSTVTAEDYHLVYDI 409

Query: 349 -----SEMFP--QIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLM 401
                 E FP   + +C +E EL+ AVQGTGLAFI +TEA+ +   S  WSV++F ML+ 
Sbjct: 410 IQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVN 469

Query: 402 LGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFN 461
           LG+GSM G    I+TP+ D    +  + KE ++ + CL+   IG++F   +GNY+  +F+
Sbjct: 470 LGLGSMFGTIEGIVTPIVD----TFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFD 525

Query: 462 DYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLF 521
           DY+ATL LL++V++E IAVC+VYG+ +F  DLK M G A S Y+  MW  +SPL+++SL 
Sbjct: 526 DYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLL 585

Query: 522 VFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQR 581
           +  + +  L+    Y AW   +       YP + L V   LV  + + +P+     F+ R
Sbjct: 586 IASVVNMGLSPP-GYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPV----VFIVR 640

Query: 582 R 582
           R
Sbjct: 641 R 641


>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score =  513 bits (1320), Expect = e-145
 Identities = 254/582 (43%), Positives = 378/582 (64%), Gaps = 21/582 (3%)

Query: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
           RP W + LQ++ A I ++VGLGN+WRFPYLCQ  GGG++LVPY+++LI+ G+PL +LELA
Sbjct: 60  RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELA 119

Query: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
           VGQR+R+GSIG W  I P L G+G +S +V  F+ +YYNVI  W+ +Y F SFQ PLPWS
Sbjct: 120 VGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWS 179

Query: 125 VCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVY 182
            CP+  NG+    + ECEK+S+T YFWYR+ L+IS S+ E+GG+ W+  LCLL+AW +V 
Sbjct: 180 ECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVG 239

Query: 183 LCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWI 242
           + +++G +S+GKV+YF++  PY VL  +L+RGL L GA +G+++MFTPK++++ +P+ W 
Sbjct: 240 MAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWR 299

Query: 243 NAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKA 302
            AATQ+FF+LGLGFG +IAF+SYN+  NNC   A +VS IN FTS+ A++V F++ GFKA
Sbjct: 300 EAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKA 359

Query: 303 TFNYENCL-----KKVSLLLTNTFD-------LEDGFLTASNLEQVKGYLASAYPSKYSE 350
               E C+     K +  L TN          +    LT  +  ++   + +    ++S 
Sbjct: 360 NIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSA 419

Query: 351 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 410
           +   +  C LE ELD +VQGTGLAFI +TEA+ +   S  WSV++F ML+ LG+GSM+G 
Sbjct: 420 L--GLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGT 477

Query: 411 TAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLL 470
            A I TP+ D    +  +PKE  +   C+    +G++F   +GNY+  +F+DY+ATL L 
Sbjct: 478 MAGITTPIID----TFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLT 533

Query: 471 LIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYIL 530
           LIV++E IAV ++YG ++F  +L  M G     ++  MW  VSPL +  L    +    +
Sbjct: 534 LIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGV 593

Query: 531 TGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 572
           T    Y AW   +       +P +A+A++  L+  +T+ IP+
Sbjct: 594 TPP-GYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPV 634


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score =  466 bits (1198), Expect = e-131
 Identities = 239/550 (43%), Positives = 349/550 (63%), Gaps = 35/550 (6%)

Query: 52  IVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFW 111
           +V G+PL +LEL+VGQR+R+GSIG W  ISP L G+G AS VV +F+++YYNVI  W+ +
Sbjct: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60

Query: 112 YLFHSFQDPLPWSVCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWE 169
           Y   SFQ PLPW  CPL  N +HT  + ECE++S+T Y+WYR+ LNIS S+ E+GG+ W+
Sbjct: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 120

Query: 170 PALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFT 229
             +CLL AW++V L +++G +S+GK++YF++  PY VLI +LIR   L+G+ +G+ +MFT
Sbjct: 121 MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT 180

Query: 230 PKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIF 289
           PK+E +  PK W  AATQ+FF+LGLGFG +IAF+SYN+  NNC   A++VS IN FTS+ 
Sbjct: 181 PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL 240

Query: 290 ASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQ--------VKGYLA 341
           A++V F++ GFKA    E C+ + S  +         FL   N+ Q        +    A
Sbjct: 241 ATLVVFAVLGFKANVINEKCITQNSETIMK-------FLKMGNISQDIIPHHINLSTVTA 293

Query: 342 SAYPSKY-------SEMFP--QIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWS 392
             Y   Y        E FP   + +C +E EL+ AVQGTGLAFI +TEA+ +   S  WS
Sbjct: 294 EDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWS 353

Query: 393 VLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEA 452
           V++F ML+ LG+GSM G    I+TP+ D    +  + KE ++ + CL+   IG++F   +
Sbjct: 354 VMFFLMLVNLGLGSMFGTIEGIVTPIVD----TFKVRKEILTVICCLLAFCIGLIFVQRS 409

Query: 453 GNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGV 512
           GNY+  +F+DY+ATL LL++V++E IAVC+VYG+ +F  DLK M G A S Y+  MW  +
Sbjct: 410 GNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYI 469

Query: 513 SPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 572
           SPL+++SL +  + +  L+    Y AW   +       YP + L V   LV  + + +P+
Sbjct: 470 SPLMLLSLLIASVVNMGLSPP-GYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPV 528

Query: 573 AALGTFVQRR 582
                F+ RR
Sbjct: 529 ----VFIVRR 534


>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score =  372 bits (955), Expect = e-103
 Identities = 216/603 (35%), Positives = 306/603 (50%), Gaps = 95/603 (15%)

Query: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
           R  W   + F+ +C+ +AVGLGNVWRFPYLC   GGG FL+PY+++ +V G+P+ +LE++
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
           +GQ M+ GSI  W  I P   G+G AS+V+ F+ + YY ++ AW F+YL  SF   LPW+
Sbjct: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 125 VCPLNGNHTGY-----DEECEKASSTQY--------------FWYRKTLNISPSLQENGG 165
            C    N          E+C  AS                  FW  K L +S  L+  G 
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230

Query: 166 VQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLM 225
           + WE  LCLL  W++VY C+ +G +STGK+VYFTA+ PY VL++ L+RG+ L GA +G++
Sbjct: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290

Query: 226 YMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSF 285
           Y   P   +L +P+ WI+A TQIFFS  +G G+L A  SYN  +NNC K AII++LINS 
Sbjct: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSG 350

Query: 286 TSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYP 345
           TS FA  V FSI GF A                     E G                 + 
Sbjct: 351 TSFFAGFVVFSILGFMAA--------------------EQG----------------VHI 374

Query: 346 SKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIG 405
           SK +E                   G GLAFI Y  A+  M V+ LW+ L+FFMLL+LG+ 
Sbjct: 375 SKVAE------------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 416

Query: 406 SMLGNTAAILTPLTDSKIISSH--LPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDY 463
           S        +T L D    S +    +E    L C +   I +    + G Y F +F+ Y
Sbjct: 417 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 476

Query: 464 AAT-LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFV 522
           +A+  +LL     E + V +VYG  RF  D+  M G     + K  W+  +PL+ + +F+
Sbjct: 477 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 536

Query: 523 F---YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 579
           F   Y    +   T  Y  W  + G        A+AL        SS +C+PL  LG  +
Sbjct: 537 FNVVYYEPLVYNNTYVYPWWGEAMGW-------AFAL--------SSMLCVPLHLLGCLL 581

Query: 580 QRR 582
           + +
Sbjct: 582 RAK 584


>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score =  365 bits (937), Expect = e-101
 Identities = 211/591 (35%), Positives = 309/591 (52%), Gaps = 104/591 (17%)

Query: 3   KARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLE 62
           KAR  W++ L F+ + + YAVGLGNVWRFPYL    GGG+FL+PY++ML + G+P+ +LE
Sbjct: 189 KARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLE 248

Query: 63  LAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLP 122
           +++GQ   QG +  W+ I P L G G+A +++S  +++YYNVI  +  +YLF SF   LP
Sbjct: 249 VSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLP 307

Query: 123 WSVC--PLNG----------------------------------------NHTGYDEECE 140
           W  C  P N                                         N T    +  
Sbjct: 308 WGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTF 367

Query: 141 KASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTA 200
            + S +YF Y   L IS  ++  G ++W  ALCL LAW++VY  + +G +++GKVVYFTA
Sbjct: 368 VSGSEEYFKYF-VLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTA 426

Query: 201 SLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLI 260
           + PY VL+I LIRG+TL GA  G+ Y  TPK E+L +   W +AATQIFFSL   +G LI
Sbjct: 427 TFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLI 486

Query: 261 AFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNT 320
             +SYN+  NNC +  +IV+  NS TSIFA  V FS+ GF A        +KV       
Sbjct: 487 TLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAN------ERKV------- 533

Query: 321 FDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTE 380
                      N+E V                              A QG G+AF+VY E
Sbjct: 534 -----------NIENV------------------------------ADQGPGIAFVVYPE 552

Query: 381 AIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDS--KIISSHLPKEAISGLVC 438
           A+  + +S  W++++F MLL LG+ +M      I+T ++D   K + +H P   +   +C
Sbjct: 553 ALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCIC 612

Query: 439 LVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTG 498
                +G     + G Y F + + YAA+ +L++I + E + + YVYGL+RF  D++ M G
Sbjct: 613 FF--IMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIG 670

Query: 499 RAVSWYWKVMWAGVSP--LLIVSLFVFYLSDYILTGTLKYQAWDASQGQLV 547
              + +WKV WA V+P  L  +  F FY  + +  G+ +Y  W    G L+
Sbjct: 671 FQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLM 721


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  365 bits (936), Expect = e-101
 Identities = 199/552 (36%), Positives = 296/552 (53%), Gaps = 64/552 (11%)

Query: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
           R  W     F+ +C+ YA+GLGNVWRFPYLC   GGG+FL+PY + LI  G+PL  LE +
Sbjct: 44  RDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECS 103

Query: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
           +GQ    G +G W+ ++P   GVG+A+ V+SF+L++YY VI +WA +YL++SF   LPW 
Sbjct: 104 LGQYTSIGGLGVWK-LAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWK 162

Query: 125 VC--PLNGNH--TGYD--EECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAW 178
            C  P N +   + Y         S+   FW R    ++  L + G ++W  A+ L +AW
Sbjct: 163 QCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAW 222

Query: 179 LVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANP 238
           ++VY CI +G   TGKVVYF+A+ PY +LII   RG+TL GA  G+++  TP   +L++ 
Sbjct: 223 ILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDS 282

Query: 239 KAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIY 298
           + W++AATQIFFS GLG GSLIA  SYN   NN  + +IIV  INS TS+FA  V FSI 
Sbjct: 283 EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIV 342

Query: 299 GFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNC 358
                                                  G++A               + 
Sbjct: 343 ---------------------------------------GFMA---------------HV 348

Query: 359 SLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPL 418
           +  S  D A  G GLAF+ Y EA+  + +S LW++L+F MLLMLGI S        +T L
Sbjct: 349 TKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITAL 408

Query: 419 TDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-LSLLLIVLVET 477
            D         +E     VC+++  IG+    + G Y F +F+ Y+A+ +SLL +V  E 
Sbjct: 409 VDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFEC 468

Query: 478 IAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDY--ILTGTLK 535
           +++ + YG+ RF  +++ M G     +WK+ W+  +P+++  +F+F       +  G   
Sbjct: 469 VSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYV 528

Query: 536 YQAWDASQGQLV 547
           +  W    G L+
Sbjct: 529 FPKWGQGVGWLM 540


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  365 bits (936), Expect = e-101
 Identities = 201/600 (33%), Positives = 322/600 (53%), Gaps = 13/600 (2%)

Query: 4   ARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLEL 63
           ARP W++  +++ A + +++    +WRF YL    GG SF   YI ML + G+PLL+LE+
Sbjct: 102 ARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEM 161

Query: 64  AVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPW 123
           A GQ MRQG +G W+ I+P++ GVG +S +V F L +Y+NV+N+W  +Y+  SFQ P+PW
Sbjct: 162 AAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPW 221

Query: 124 SVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYL 183
             CPL  N +G+D ECE+ + + YFWY++ L  S  +++ G   +   L   L W +V  
Sbjct: 222 EKCPLTMNSSGFDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGA 281

Query: 184 CILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWIN 243
            ++ G +STGKV+Y    LP  +++ + IR L L GA  GL  +   KI  + N   W  
Sbjct: 282 FMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSL 341

Query: 244 AATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKAT 303
           A  Q+  + G+G GS+ + ASY   SNNC   A +VS+IN  T +  +   F + GF AT
Sbjct: 342 AGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWAT 401

Query: 304 FNYENCLKK---VSLLLTNTFDLEDGFLTASNL----EQVKGYLASAYPSKYSEM-FPQI 355
                C ++   + L L N   L        NL      +     S  P     M   ++
Sbjct: 402 VITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREV 461

Query: 356 KNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAIL 415
             C++E++   A +G   AF+ + EA+  +  S  WS ++F MLL +G+ S +G    I+
Sbjct: 462 TECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGII 521

Query: 416 TPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLV 475
           TPL D+        K  I G V L+    G+ FT  +G+Y+  + +DY     ++++V+ 
Sbjct: 522 TPLQDTFSFFRKHTKLLIVG-VFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVF 580

Query: 476 ETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLK 535
           ET+AV + YG RRF +DL  + G  +S  +  +W  + P++++ +FV  +  ++    + 
Sbjct: 581 ETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMV-HLCMKPIT 639

Query: 536 YQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQR---RLKRGDADPVA 592
           Y +WD+S  + V + YP +AL ++  L A   + IP   +   + R   R K GD    A
Sbjct: 640 YMSWDSSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCRIHRIPFRPKSGDGPMTA 699


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score =  364 bits (935), Expect = e-100
 Identities = 213/610 (34%), Positives = 317/610 (51%), Gaps = 102/610 (16%)

Query: 8   WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
           W N ++FV   + YAVGLGNVWRFPYLC   GGG+F+ PY IMLI  G+PL ++EL+ GQ
Sbjct: 30  WGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQ 89

Query: 68  RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126
              QG +G WR ISP   GVG   +VVS ++ +YYNV+   AF+Y F S    LPW+ C 
Sbjct: 90  FASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCN 148

Query: 127 --------------------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSL 160
                                     P N +H   +   ++ S ++ +W    L +S  +
Sbjct: 149 NPWNTHDCAGVLDASNLTNGSRPAALPSNLSHL-LNHSLQRTSPSEEYWRLYVLKLSDDI 207

Query: 161 QENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGA 220
              G V+     CL ++WLVV+LC++RG +S+GKVVYFTA+ PY VL I  +RG+TL GA
Sbjct: 208 GNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGA 267

Query: 221 TNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVS 280
            +G+MY  TP+ +++   K W +AA+QIF+SLG  +G LI  ASYN+  NNC + ++I+S
Sbjct: 268 FDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIIS 327

Query: 281 LINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYL 340
           + N  TS++A  V FS                                       + G++
Sbjct: 328 ITNCATSVYAGFVIFS---------------------------------------ILGFM 348

Query: 341 ASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLL 400
           A+      S +               A  G GLAF+ Y EA+  + +S LWS+L+FFML+
Sbjct: 349 ANHLGVDVSRV---------------ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 393

Query: 401 MLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGL-VCLVNCAIGMVFTMEAGNYWFDI 459
           +LG+G+       ++T + D       L K+    L V +    +G+  T +AG YW  +
Sbjct: 394 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLL 453

Query: 460 FNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVS 519
            ++YAA+ SL++I  +  +A+ Y+YG R +  D++ M G     ++++ W  VSP +I  
Sbjct: 454 MDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFF 513

Query: 520 LFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 579
           + VF +  Y       YQ             YP +A+A+  L+  SS +CIPL A+    
Sbjct: 514 ILVFTVIQYQPITYNHYQ-------------YPGWAVAIGFLMALSSVLCIPLYAM---- 556

Query: 580 QRRLKRGDAD 589
             RL R D D
Sbjct: 557 -FRLCRTDGD 565


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  364 bits (935), Expect = e-100
 Identities = 213/610 (34%), Positives = 317/610 (51%), Gaps = 102/610 (16%)

Query: 8   WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
           W N ++FV   + YAVGLGNVWRFPYLC   GGG+F+ PY IMLI  G+PL ++EL+ GQ
Sbjct: 103 WGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQ 162

Query: 68  RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126
              QG +G WR ISP   GVG   +VVS ++ +YYNV+   AF+Y F S    LPW+ C 
Sbjct: 163 FASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCN 221

Query: 127 --------------------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSL 160
                                     P N +H   +   ++ S ++ +W    L +S  +
Sbjct: 222 NPWNTHDCAGVLDASNLTNGSRPAALPSNLSHL-LNHSLQRTSPSEEYWRLYVLKLSDDI 280

Query: 161 QENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGA 220
              G V+     CL ++WLVV+LC++RG +S+GKVVYFTA+ PY VL I  +RG+TL GA
Sbjct: 281 GNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGA 340

Query: 221 TNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVS 280
            +G+MY  TP+ +++   K W +AA+QIF+SLG  +G LI  ASYN+  NNC + ++I+S
Sbjct: 341 FDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIIS 400

Query: 281 LINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYL 340
           + N  TS++A  V FS                                       + G++
Sbjct: 401 ITNCATSVYAGFVIFS---------------------------------------ILGFM 421

Query: 341 ASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLL 400
           A+      S +               A  G GLAF+ Y EA+  + +S LWS+L+FFML+
Sbjct: 422 ANHLGVDVSRV---------------ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 466

Query: 401 MLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGL-VCLVNCAIGMVFTMEAGNYWFDI 459
           +LG+G+       ++T + D       L K+    L V +    +G+  T +AG YW  +
Sbjct: 467 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLL 526

Query: 460 FNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVS 519
            ++YAA+ SL++I  +  +A+ Y+YG R +  D++ M G     ++++ W  VSP +I  
Sbjct: 527 MDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFF 586

Query: 520 LFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 579
           + VF +  Y       YQ             YP +A+A+  L+  SS +CIPL A+    
Sbjct: 587 ILVFTVIQYQPITYNHYQ-------------YPGWAVAIGFLMALSSVLCIPLYAM---- 629

Query: 580 QRRLKRGDAD 589
             RL R D D
Sbjct: 630 -FRLCRTDGD 638


>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score =  364 bits (935), Expect = e-100
 Identities = 213/610 (34%), Positives = 317/610 (51%), Gaps = 102/610 (16%)

Query: 8   WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
           W N ++FV   + YAVGLGNVWRFPYLC   GGG+F+ PY IMLI  G+PL ++EL+ GQ
Sbjct: 49  WGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQ 108

Query: 68  RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126
              QG +G WR ISP   GVG   +VVS ++ +YYNV+   AF+Y F S    LPW+ C 
Sbjct: 109 FASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCN 167

Query: 127 --------------------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSL 160
                                     P N +H   +   ++ S ++ +W    L +S  +
Sbjct: 168 NPWNTHDCAGVLDASNLTNGSRPAALPSNLSHL-LNHSLQRTSPSEEYWRLYVLKLSDDI 226

Query: 161 QENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGA 220
              G V+     CL ++WLVV+LC++RG +S+GKVVYFTA+ PY VL I  +RG+TL GA
Sbjct: 227 GNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGA 286

Query: 221 TNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVS 280
            +G+MY  TP+ +++   K W +AA+QIF+SLG  +G LI  ASYN+  NNC + ++I+S
Sbjct: 287 FDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIIS 346

Query: 281 LINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYL 340
           + N  TS++A  V FS                                       + G++
Sbjct: 347 ITNCATSVYAGFVIFS---------------------------------------ILGFM 367

Query: 341 ASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLL 400
           A+      S +               A  G GLAF+ Y EA+  + +S LWS+L+FFML+
Sbjct: 368 ANHLGVDVSRV---------------ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 412

Query: 401 MLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGL-VCLVNCAIGMVFTMEAGNYWFDI 459
           +LG+G+       ++T + D       L K+    L V +    +G+  T +AG YW  +
Sbjct: 413 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLL 472

Query: 460 FNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVS 519
            ++YAA+ SL++I  +  +A+ Y+YG R +  D++ M G     ++++ W  VSP +I  
Sbjct: 473 MDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFF 532

Query: 520 LFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 579
           + VF +  Y       YQ             YP +A+A+  L+  SS +CIPL A+    
Sbjct: 533 ILVFTVIQYQPITYNHYQ-------------YPGWAVAIGFLMALSSVLCIPLYAM---- 575

Query: 580 QRRLKRGDAD 589
             RL R D D
Sbjct: 576 -FRLCRTDGD 584


>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score =  358 bits (918), Expect = 1e-98
 Identities = 203/599 (33%), Positives = 306/599 (51%), Gaps = 86/599 (14%)

Query: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
           R  W   + F+ + I YAV LGNVWRFPY+C   GGG+FL+PY IM I  G+PL Y+ELA
Sbjct: 79  RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELA 138

Query: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
           +GQ  R G I  WR I P   G+G A  +++F+++ YYN I AWA +YL  SF D LPW+
Sbjct: 139 LGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWT 198

Query: 125 VCPLN---GNHTGYDEE------CEKASSTQYFWYRKTLNI--SPSLQENGGVQWEPALC 173
            C  +   GN T Y  E          S  + F+ R  L I  S  LQ+ GG+ W+ ALC
Sbjct: 199 SCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALC 258

Query: 174 LLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIE 233
           ++L + V+Y  I +G +++GKVV+ TA+ PY +L + L+RG TL GA  G+++   P  +
Sbjct: 259 IMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQ 318

Query: 234 QLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIV 293
           +L     WI+AA QIFFSLG GFG L+AFASYN+ +NNC + A++ S++N  TS  +  V
Sbjct: 319 KLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFV 378

Query: 294 TFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFP 353
            F++ G+ A    E+                           V      A PS       
Sbjct: 379 IFTVLGYMAEMRNED---------------------------VSEVAKDAGPS------- 404

Query: 354 QIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAA 413
                              L FI Y EAI NM  S  +++++F ML+ LG+ S       
Sbjct: 405 -------------------LLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEG 445

Query: 414 ILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTME-AGNYWFDIFNDYAATLSLLLI 472
           ++T + D +       +     L  ++ C  G + T+   G Y   +  +YA   ++L +
Sbjct: 446 VITAVLD-EFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTV 504

Query: 473 VLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTG 532
            L+E +AV + YG+ +F  D+K M G +  W+W++ W  +SPL ++ +   +L       
Sbjct: 505 ALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFL------- 557

Query: 533 TLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIP-------LAALGTFVQRRLK 584
                     Q +L   +YP +++ +   +  SS +CIP       +   GTF +R +K
Sbjct: 558 ------MSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIK 610


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  354 bits (908), Expect = 1e-97
 Identities = 210/595 (35%), Positives = 304/595 (51%), Gaps = 81/595 (13%)

Query: 3   KARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLE 62
           K R  W N ++FV +     +GLGNVWRFPYLC   GGG+F +PY I   V G+P+ +LE
Sbjct: 34  KDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLE 93

Query: 63  LAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLP 122
           +A+GQ   QGS+ AWR I P   G+G+ASVV+  +L++YY +I AWA +YLF SF   LP
Sbjct: 94  VALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELP 153

Query: 123 WSVCP-----------LNGNHTGYDEECEKASS-TQYFWYRKTLNISPSLQENGGVQWEP 170
           W+ C            LN +  G     E  +S    FW R+ L I+  + + G ++WE 
Sbjct: 154 WTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWEL 213

Query: 171 ALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTP 230
           ALCLLLAW++ Y CI +G +STGKVVYFTA+ PY +L+I LIRG+TL GA  G++Y   P
Sbjct: 214 ALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKP 273

Query: 231 KIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFA 290
            + +L +P+ W++A TQIFFS  +  G L A  SYN+  NNC K  I +  +NS TS  A
Sbjct: 274 DLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVA 333

Query: 291 SIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSE 350
             V FSI GF +                     E G   +   E   G    A+P     
Sbjct: 334 GFVVFSILGFMSQ--------------------EQGVPISEVAESGPGLAFIAFP----- 368

Query: 351 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 410
                                        +A+  M +SQLWS L+F ML+ LG+ S    
Sbjct: 369 -----------------------------KAVTMMPLSQLWSCLFFIMLIFLGLDSQFVC 399

Query: 411 TAAILTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-L 467
              ++T   D   + +     +E +   + ++   IG+    E G Y F +F+ YA++ +
Sbjct: 400 VECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGI 459

Query: 468 SLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSD 527
            LL + L E + + +VYG  RF  +++ M G       K+ W  ++P L ++ F+F LS 
Sbjct: 460 CLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSK 519

Query: 528 YILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRR 582
           Y     LKY              YP +  ++   L  SS +C+PL  + T ++ R
Sbjct: 520 YT---PLKYNN---------VYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTR 562


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  354 bits (908), Expect = 1e-97
 Identities = 210/595 (35%), Positives = 304/595 (51%), Gaps = 81/595 (13%)

Query: 3   KARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLE 62
           K R  W N ++FV +     +GLGNVWRFPYLC   GGG+F +PY I   V G+P+ +LE
Sbjct: 34  KDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLE 93

Query: 63  LAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLP 122
           +A+GQ   QGS+ AWR I P   G+G+ASVV+  +L++YY +I AWA +YLF SF   LP
Sbjct: 94  VALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELP 153

Query: 123 WSVCP-----------LNGNHTGYDEECEKASS-TQYFWYRKTLNISPSLQENGGVQWEP 170
           W+ C            LN +  G     E  +S    FW R+ L I+  + + G ++WE 
Sbjct: 154 WTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWEL 213

Query: 171 ALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTP 230
           ALCLLLAW++ Y CI +G +STGKVVYFTA+ PY +L+I LIRG+TL GA  G++Y   P
Sbjct: 214 ALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKP 273

Query: 231 KIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFA 290
            + +L +P+ W++A TQIFFS  +  G L A  SYN+  NNC K  I +  +NS TS  A
Sbjct: 274 DLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVA 333

Query: 291 SIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSE 350
             V FSI GF +                     E G   +   E   G    A+P     
Sbjct: 334 GFVVFSILGFMSQ--------------------EQGVPISEVAESGPGLAFIAFP----- 368

Query: 351 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 410
                                        +A+  M +SQLWS L+F ML+ LG+ S    
Sbjct: 369 -----------------------------KAVTMMPLSQLWSCLFFIMLIFLGLDSQFVC 399

Query: 411 TAAILTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-L 467
              ++T   D   + +     +E +   + ++   IG+    E G Y F +F+ YA++ +
Sbjct: 400 VECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGI 459

Query: 468 SLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSD 527
            LL + L E + + +VYG  RF  +++ M G       K+ W  ++P L ++ F+F LS 
Sbjct: 460 CLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSK 519

Query: 528 YILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRR 582
           Y     LKY              YP +  ++   L  SS +C+PL  + T ++ R
Sbjct: 520 YT---PLKYNN---------VYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTR 562


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  354 bits (908), Expect = 1e-97
 Identities = 210/595 (35%), Positives = 304/595 (51%), Gaps = 81/595 (13%)

Query: 3   KARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLE 62
           K R  W N ++FV +     +GLGNVWRFPYLC   GGG+F +PY I   V G+P+ +LE
Sbjct: 34  KDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLE 93

Query: 63  LAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLP 122
           +A+GQ   QGS+ AWR I P   G+G+ASVV+  +L++YY +I AWA +YLF SF   LP
Sbjct: 94  VALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELP 153

Query: 123 WSVCP-----------LNGNHTGYDEECEKASS-TQYFWYRKTLNISPSLQENGGVQWEP 170
           W+ C            LN +  G     E  +S    FW R+ L I+  + + G ++WE 
Sbjct: 154 WTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWEL 213

Query: 171 ALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTP 230
           ALCLLLAW++ Y CI +G +STGKVVYFTA+ PY +L+I LIRG+TL GA  G++Y   P
Sbjct: 214 ALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKP 273

Query: 231 KIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFA 290
            + +L +P+ W++A TQIFFS  +  G L A  SYN+  NNC K  I +  +NS TS  A
Sbjct: 274 DLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVA 333

Query: 291 SIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSE 350
             V FSI GF +                     E G   +   E   G    A+P     
Sbjct: 334 GFVVFSILGFMSQ--------------------EQGVPISEVAESGPGLAFIAFP----- 368

Query: 351 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 410
                                        +A+  M +SQLWS L+F ML+ LG+ S    
Sbjct: 369 -----------------------------KAVTMMPLSQLWSCLFFIMLIFLGLDSQFVC 399

Query: 411 TAAILTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-L 467
              ++T   D   + +     +E +   + ++   IG+    E G Y F +F+ YA++ +
Sbjct: 400 VECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGI 459

Query: 468 SLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSD 527
            LL + L E + + +VYG  RF  +++ M G       K+ W  ++P L ++ F+F LS 
Sbjct: 460 CLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSK 519

Query: 528 YILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRR 582
           Y     LKY              YP +  ++   L  SS +C+PL  + T ++ R
Sbjct: 520 YT---PLKYNN---------VYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTR 562


>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score =  350 bits (899), Expect = 2e-96
 Identities = 208/603 (34%), Positives = 297/603 (49%), Gaps = 105/603 (17%)

Query: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
           R  W   + F+ +C+ +AVGLGNVWRFPYLC   GGG FL+PY+++ +V G+P+ +LE++
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
           +GQ M+ GSI  W  I P   G+G AS+V+ F+ + YY ++ AW F+YL  SF   LPW+
Sbjct: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 125 VCPLNGNHTGY-----DEECEKASSTQY--------------FWYRKTLNISPSLQENGG 165
            C    N          E+C  AS                  FW  K L +S  L+  G 
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230

Query: 166 VQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLM 225
           + WE  LCLL  W++VY C+ +G +STGK+VYFTA+ PY VL++ L+RG+ L GA +G++
Sbjct: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290

Query: 226 YMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSF 285
           Y   P   +L +P+ WI+A TQIFFS  +G G+L A  SYN  +NNC           + 
Sbjct: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY----------NG 340

Query: 286 TSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYP 345
           TS FA  V FSI GF A                     E G                 + 
Sbjct: 341 TSFFAGFVVFSILGFMAA--------------------EQG----------------VHI 364

Query: 346 SKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIG 405
           SK +E                   G GLAFI Y  A+  M V+ LW+ L+FFMLL+LG+ 
Sbjct: 365 SKVAE------------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 406

Query: 406 SMLGNTAAILTPLTDSKIISSH--LPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDY 463
           S        +T L D    S +    +E    L C +   I +    + G Y F +F+ Y
Sbjct: 407 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 466

Query: 464 AAT-LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFV 522
           +A+  +LL     E + V +VYG  RF  D+  M G     + K  W+  +PL+ + +F+
Sbjct: 467 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 526

Query: 523 F---YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 579
           F   Y    +   T  Y  W  + G        A+AL        SS +C+PL  LG  +
Sbjct: 527 FNVVYYEPLVYNNTYVYPWWGEAMGW-------AFAL--------SSMLCVPLHLLGCLL 571

Query: 580 QRR 582
           + +
Sbjct: 572 RAK 574


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  346 bits (888), Expect = 3e-95
 Identities = 201/589 (34%), Positives = 299/589 (50%), Gaps = 98/589 (16%)

Query: 8   WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
           W N ++FV +     +GLGNVWRFPYLC   GGG+FL+PY++  I  G+P+ +LE A+GQ
Sbjct: 53  WNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQ 112

Query: 68  RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCP 127
              +G I  WR + P   G+G A+ V+   L++YY +I AWA +YL + F   LPW+ C 
Sbjct: 113 FTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATC- 171

Query: 128 LNGNHTGYDEEC---EKASSTQY--------------FWYRKTLNISPSLQENGGVQWEP 170
               H    E C   +K + + Y              FW  + L IS  ++  G ++WE 
Sbjct: 172 ---GHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWEL 228

Query: 171 ALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTP 230
           ALCLL AW + Y CI +GT+STGKVVY TA+ PY +L+I LIRG+TL GA+ G+ +   P
Sbjct: 229 ALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYP 288

Query: 231 KIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFA 290
            + +L++P+ W++A TQIFFS  +  G L A  SYN  +NNC +  I++  +NS TS  A
Sbjct: 289 DLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVA 348

Query: 291 SIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSE 350
               FS+ GF A                     E G   A   E   G            
Sbjct: 349 GFAIFSVLGFMA--------------------YEQGVPIAEVAESGPG------------ 376

Query: 351 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 410
                                 LAFI Y +A+  M +S LW+ L+F ML+ LG+ S    
Sbjct: 377 ----------------------LAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVC 414

Query: 411 TAAILTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-L 467
             +++T + D   K+      +E +   + +++  +G+V   E G Y F +F+ YAA+ +
Sbjct: 415 VESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGM 474

Query: 468 SLLLIVLVETIAVCYVYGLRRFESDLKAMTG----RAVSWYWKVMWAGVSPLLIVSLFVF 523
            LL + + E I + +VYG  RF  +++ M G      + W W +M    +P +   +F+F
Sbjct: 475 CLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIM----TPGICAGIFIF 530

Query: 524 YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 572
           +L  Y     LKY         + T  YPA+   +  L+  SS +CIPL
Sbjct: 531 FLIKY---KPLKY-------NNIYT--YPAWGYGIGWLMALSSMLCIPL 567


>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score =  342 bits (877), Expect = 6e-94
 Identities = 195/559 (34%), Positives = 289/559 (51%), Gaps = 75/559 (13%)

Query: 8   WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
           W   L F+ +CI Y VGLGNVWRFPY     GGG+FLVPY +ML + G+PL +LEL++GQ
Sbjct: 40  WTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQ 99

Query: 68  RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126
               G +  W+ ISP   G G A +++   +++YYN+I A+  +YLF S    LPW  C 
Sbjct: 100 FSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCG 158

Query: 127 -------------PLNGNHT-GYDEECEKASSTQYFWYRKTLNI--SPSLQENGGVQWEP 170
                          +GN     +  C  + S +Y W R  L+I  S  +   G ++W  
Sbjct: 159 NWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEY-WSRYVLHIQGSQGIGSPGEIRWNL 217

Query: 171 ALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTP 230
            LCLLLAW++V+LCIL+G +S+GKVVYFTA+ PY +L++ L+RG+TL GA  G+ +  TP
Sbjct: 218 CLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTP 277

Query: 231 KIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFA 290
           +   L + K WI AA QIF+SLG+GFG L+ FASYN    N  +   IV+L N+ TSI A
Sbjct: 278 QFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILA 337

Query: 291 SIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSE 350
               FS+ G+                             +  L      +A A P     
Sbjct: 338 GFAIFSVLGY----------------------------MSQELGVPVDQVAKAGPGLAFV 369

Query: 351 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 410
           ++PQ                          A+  + +S  WS L+FFMLL LG+ S    
Sbjct: 370 VYPQ--------------------------AMTMLPLSPFWSFLFFFMLLTLGLDSQFAF 403

Query: 411 TAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLL 470
              I+T +TD         K   SGL+C+    +G++ T + G YW  + +DY+A+  L+
Sbjct: 404 LETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLM 463

Query: 471 LIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYIL 530
           ++V+   +AV  VYG++RF  D+  M G     Y++  W  +SP  +++L V+ +  Y  
Sbjct: 464 VVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQP 523

Query: 531 T--GTLKYQAWDASQGQLV 547
           +  G+ ++  W    G L+
Sbjct: 524 SEYGSYRFPPWAELLGILM 542


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  341 bits (874), Expect = 1e-93
 Identities = 201/589 (34%), Positives = 288/589 (48%), Gaps = 91/589 (15%)

Query: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
           R  W++ + FV +     VGLGNVWRFPYLC   GGG+FL+PY I L   G+P+ +LE+ 
Sbjct: 41  REKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEII 100

Query: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
           +GQ   +G I  W  I P  SG+G ASVV+   L++YY VI AWA +YLF SFQ  LPW+
Sbjct: 101 IGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA 160

Query: 125 VCPLNGNHTGYDEECEK------------ASSTQY------FWYRKTLNISPSLQENGGV 166
            C    NH+     C +             SST +      FW R  L++SP +   G +
Sbjct: 161 HC----NHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSL 216

Query: 167 QWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMY 226
           +W+ ALCLLL WLV + CI +G  STGKVVYFTA+ P+ +L++ L+RGLTL GA  G+ +
Sbjct: 217 KWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKF 276

Query: 227 MFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFT 286
              P I +L +P+ WI+A TQIFFS  +  G++ +  SYN+   N  +  +++  +NS T
Sbjct: 277 YLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGT 336

Query: 287 SIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPS 346
           S  +    FSI GF A                     E G   A   E   G    AYP 
Sbjct: 337 SFVSGFAIFSILGFMAQ--------------------EQGVDIADVAESGPGLAFIAYP- 375

Query: 347 KYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGS 406
                                            +A+  M +   WS+L+F MLL+LG+ S
Sbjct: 376 ---------------------------------KAVTMMPLPTFWSILFFIMLLLLGLDS 402

Query: 407 MLGNTAAILTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYA 464
                   +T L D     +     +E     VC ++  +G+    E G Y F +F+ YA
Sbjct: 403 QFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYA 462

Query: 465 AT-LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVF 523
           A+ + LL +   E   + ++YG       ++ M G     + K  WA ++P+L V  F+F
Sbjct: 463 ASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIF 522

Query: 524 YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 572
            L  Y+    L Y           T  YP +A+ +   L  SS +C+PL
Sbjct: 523 SLVKYV---PLTYNK---------TYVYPNWAIGLGWSLALSSMLCVPL 559


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  341 bits (874), Expect = 1e-93
 Identities = 201/589 (34%), Positives = 288/589 (48%), Gaps = 91/589 (15%)

Query: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
           R  W++ + FV +     VGLGNVWRFPYLC   GGG+FL+PY I L   G+P+ +LE+ 
Sbjct: 41  REKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEII 100

Query: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
           +GQ   +G I  W  I P  SG+G ASVV+   L++YY VI AWA +YLF SFQ  LPW+
Sbjct: 101 IGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA 160

Query: 125 VCPLNGNHTGYDEECEK------------ASSTQY------FWYRKTLNISPSLQENGGV 166
            C    NH+     C +             SST +      FW R  L++SP +   G +
Sbjct: 161 HC----NHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSL 216

Query: 167 QWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMY 226
           +W+ ALCLLL WLV + CI +G  STGKVVYFTA+ P+ +L++ L+RGLTL GA  G+ +
Sbjct: 217 KWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKF 276

Query: 227 MFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFT 286
              P I +L +P+ WI+A TQIFFS  +  G++ +  SYN+   N  +  +++  +NS T
Sbjct: 277 YLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGT 336

Query: 287 SIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPS 346
           S  +    FSI GF A                     E G   A   E   G    AYP 
Sbjct: 337 SFVSGFAIFSILGFMAQ--------------------EQGVDIADVAESGPGLAFIAYP- 375

Query: 347 KYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGS 406
                                            +A+  M +   WS+L+F MLL+LG+ S
Sbjct: 376 ---------------------------------KAVTMMPLPTFWSILFFIMLLLLGLDS 402

Query: 407 MLGNTAAILTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYA 464
                   +T L D     +     +E     VC ++  +G+    E G Y F +F+ YA
Sbjct: 403 QFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYA 462

Query: 465 AT-LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVF 523
           A+ + LL +   E   + ++YG       ++ M G     + K  WA ++P+L V  F+F
Sbjct: 463 ASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIF 522

Query: 524 YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 572
            L  Y+    L Y           T  YP +A+ +   L  SS +C+PL
Sbjct: 523 SLVKYV---PLTYNK---------TYVYPNWAIGLGWSLALSSMLCVPL 559


>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score =  340 bits (872), Expect = 2e-93
 Identities = 204/590 (34%), Positives = 293/590 (49%), Gaps = 89/590 (15%)

Query: 8   WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
           W N ++FV +     +GLGNVWRFPYLC   GGG+F +PY++ L   G+P+  LE A+GQ
Sbjct: 35  WNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQ 94

Query: 68  RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126
              QG + AWR I P   G+G AS ++   L++YY ++ AWA +YLF SF   LPW  C 
Sbjct: 95  YTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCY 154

Query: 127 ------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCL 174
                         NG+  G  E     S    FW R+ L IS  +Q  G ++WE ALCL
Sbjct: 155 HEWNTEHCMEFQKTNGSLNGTSENA--TSPVIEFWERRVLKISDGIQHLGALRWELALCL 212

Query: 175 LLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQ 234
           LLAW++ Y CI +G +STGKVVYFTA+ PY +L++ LIRG+TL GA  G+ +   P + +
Sbjct: 213 LLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTR 272

Query: 235 LANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVT 294
           L +P+ W++A TQIFFS  +  G L A  SYN+  NNC +  I +  +NS TS  A    
Sbjct: 273 LWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAI 332

Query: 295 FSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQ 354
           FSI GF +                     E G   +   E   G    AYP         
Sbjct: 333 FSILGFMSQ--------------------EQGVPISEVAESGPGLAFIAYP--------- 363

Query: 355 IKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAI 414
                                     A+  +  S LW+  +FFM+++LG+ S      ++
Sbjct: 364 -------------------------RAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESL 398

Query: 415 LTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-LSLLL 471
           +T L D    +      +E +   V +V+  +G++   E G Y F +F+ YAA+ + LL 
Sbjct: 399 VTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLF 458

Query: 472 IVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYI-L 530
           + + E++ V +VYG +RF  +++ M G       K  W  ++P +  + F+F L  Y  L
Sbjct: 459 VAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPL 518

Query: 531 TGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIP---LAALGT 577
           T   KY              YP +  A+  LL  SS +CIP   L  LGT
Sbjct: 519 TYNKKY-------------TYPWWGDALGWLLALSSMVCIPAWSLYRLGT 555


>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score =  335 bits (860), Expect = 5e-92
 Identities = 200/571 (35%), Positives = 298/571 (52%), Gaps = 87/571 (15%)

Query: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
           R  W   + F+ + + +AV L NVWRFPYLC   GGG+FL+PY + LI+ GMPL Y+ELA
Sbjct: 56  RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115

Query: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
           +GQ  R+G+   W+ I P+  GVG A ++++ ++  YYNVI AW+ +YLF SF   LPW+
Sbjct: 116 LGQYNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174

Query: 125 VCP-------------LNG----NHTGYDEECEKASSTQYFWYRKTLNI--SPSLQENGG 165
            C              LNG    NHT Y +   K +    F+ R  L++  S  + + G 
Sbjct: 175 DCGHTWNSPNCTDPKLLNGSVLGNHTKYSKY--KFTPAAEFYERGVLHLHESSGIHDIGL 232

Query: 166 VQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLM 225
            QW+  LCL++  +V+Y  + +G +++GKVV+ TA+LPY VL + L+ G+TL GA+NG+ 
Sbjct: 233 PQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGIN 292

Query: 226 YMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSF 285
                   +L     WI+AATQIFFSLG GFG LIAFASYN+  NNC + A++ S IN  
Sbjct: 293 AYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCI 352

Query: 286 TSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYP 345
           TS  +    FSI G+ A   +E+ +                     N+E V         
Sbjct: 353 TSFVSGFAIFSILGYMA---HEHKV---------------------NIEDV--------- 379

Query: 346 SKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIG 405
                                A +G GL FI+Y EAI  +  S  W+V++F MLL LG+ 
Sbjct: 380 ---------------------ATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLD 418

Query: 406 SMLGNTAAILTPLTDS-KIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYA 464
           S +G   A++T L D  +++  H  ++  +  V      + +    + G Y   + + +A
Sbjct: 419 SSMGGMEAVITGLADDFQVLKRH--RKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFA 476

Query: 465 ATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSP-----LLIVS 519
           A  S+L  VL+E I V + YG+ RF +D++ M G     YW++ W  VSP     +++VS
Sbjct: 477 AGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVS 536

Query: 520 LFVF---YLSDYILTGTLKYQAWDASQGQLV 547
           +  F      DYI      +  W  +   +V
Sbjct: 537 IINFKPLTYDDYIFPPWANWVGWGIALSSMV 567


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  326 bits (836), Expect = 3e-89
 Identities = 193/583 (33%), Positives = 290/583 (49%), Gaps = 101/583 (17%)

Query: 8   WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
           W+    ++ + I YAVGLGNVWRFPYL    GGG+FL+PY IML + G+PL +LE ++GQ
Sbjct: 39  WSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQ 98

Query: 68  RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPW---- 123
               G +  WR I P   GVG+  V++S F+++YYNVI A++ +Y+F SFQ  LPW    
Sbjct: 99  FASLGPVSVWR-ILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCS 157

Query: 124 -------------SVCPLNGNHTGYDEECEKASS----------------------TQYF 148
                        + C ++  + G  E  +   S                      ++ +
Sbjct: 158 SWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQY 217

Query: 149 WYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLI 208
           W +  L  S  + E G + W  ALCLLLAWL+V   + +G +S+GKVVYFTA  PY VL+
Sbjct: 218 WNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLL 277

Query: 209 IYLIRGLTLHGATNGLMYMF--TPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYN 266
           I L+RG TL GA+ G+ Y         +L   + W +AATQIF+SL + +G L+A +SYN
Sbjct: 278 ILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYN 337

Query: 267 EPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDG 326
           +  NNC   AI+V L N  TS+FA    FSI G  A  +     K+VS ++ + FDL   
Sbjct: 338 KFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISG----KEVSQVVKSGFDL--- 390

Query: 327 FLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNME 386
                                                          AFI Y EA+  + 
Sbjct: 391 -----------------------------------------------AFIAYPEALAQLP 403

Query: 387 VSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGM 446
               WS+L+FFMLL LG+ S   +   I T + D         +  I+   CLV   +G+
Sbjct: 404 GGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGL 463

Query: 447 VFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTG--RAVSW- 503
           V   +AG YW  + + + A   +L+  ++E + + ++YG  RF  D + M G  R + W 
Sbjct: 464 VCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWL 523

Query: 504 YWKVMWAGVSPLLIVSLFVFYLSDYILT--GTLKYQAWDASQG 544
           +W+  W  ++P+L++++F++ L  +     G + Y  W  + G
Sbjct: 524 WWRACWFVITPILLIAIFIWSLVQFHRPNYGAIPYPDWGVALG 566


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score =  290 bits (743), Expect = 2e-78
 Identities = 184/539 (34%), Positives = 258/539 (47%), Gaps = 95/539 (17%)

Query: 69  MRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPL 128
           M+ GSI  W  I P   G+G AS+V+ F+ + YY ++ AW F+YL  SF   LPW+ C  
Sbjct: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59

Query: 129 NGNHTGY-----DEECEKASSTQY--------------FWYRKTLNISPSLQENGGVQWE 169
             N          E+C  AS                  FW  K L +S  L+  G + WE
Sbjct: 60  TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119

Query: 170 PALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFT 229
             LCLL  W++VY C+ +G +STGK+VYFTA+ PY VL++ L+RG+ L GA +G++Y   
Sbjct: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179

Query: 230 PKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIF 289
           P   +L +P+ WI+A TQIFFS  +G G+L A  SYN  +NNC K AII++LINS TS F
Sbjct: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239

Query: 290 ASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYS 349
           A  V FSI GF A                     E G                 + SK +
Sbjct: 240 AGFVVFSILGFMAA--------------------EQG----------------VHISKVA 263

Query: 350 EMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLG 409
           E                   G GLAFI Y  A+  M V+ LW+ L+FFMLL+LG+ S   
Sbjct: 264 E------------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFV 305

Query: 410 NTAAILTPLTDSKIISSH--LPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT- 466
                +T L D    S +    +E    L C +   I +    + G Y F +F+ Y+A+ 
Sbjct: 306 GVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG 365

Query: 467 LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVF--- 523
            +LL     E + V +VYG  RF  D+  M G     + K  W+  +PL+ + +F+F   
Sbjct: 366 TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV 425

Query: 524 YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRR 582
           Y    +   T  Y  W  + G        A+AL        SS +C+PL  LG  ++ +
Sbjct: 426 YYEPLVYNNTYVYPWWGEAMGW-------AFAL--------SSMLCVPLHLLGCLLRAK 469


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  284 bits (726), Expect = 2e-76
 Identities = 186/590 (31%), Positives = 297/590 (50%), Gaps = 88/590 (14%)

Query: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
           R  W   + F+ + I +AV L NVWRFPYLC   GGG+FLVPY++ +++ GMPL Y+ELA
Sbjct: 60  RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELA 119

Query: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
           +GQ  R+G+ G W+ I P L GVG   +++S ++  +YNVI AWA  YLF SF   LPW 
Sbjct: 120 LGQFNREGAAGVWK-ICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWI 178

Query: 125 VC---------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPS--LQENGGVQ 167
            C                 +G+ +G ++      + +YF  R  L++  S  + + G  +
Sbjct: 179 HCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYF-ERGVLHLHQSHGIDDLGPPR 237

Query: 168 WEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYM 227
           W+   CL+L  +++Y  + +G +++GKVV+ TA++PY VL   L+RG+TL GA +G+   
Sbjct: 238 WQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAY 297

Query: 228 FTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTS 287
            +    +L     WI+AATQ+ FSLG+GFG LIAF+SYN+ +NNC + AI+ + INS TS
Sbjct: 298 LSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTS 357

Query: 288 IFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGY-LASAYPS 346
             +  V FS  G+ A        +K S+ + +      G +     E +    L+SA+  
Sbjct: 358 FSSGFVVFSFLGYMA--------QKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAV 409

Query: 347 KYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGS 406
            +  M   +   S    +++ + G    F +     ++ E+  L+ VL  F+L       
Sbjct: 410 VFFIMLLTLGIDSAMGGMESVITGLIDEFQLLH---RHRELFTLFIVLATFLL------- 459

Query: 407 MLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT 466
                                        L C+ N  I  VFT         + + +AA 
Sbjct: 460 ----------------------------SLFCVTNGGI-YVFT---------LLDHFAAG 481

Query: 467 LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSP-----LLIVSLF 521
            S+L  VL+E I V + YG+ +F  D++ MTG+  S YW++ W  VSP     +++VS+ 
Sbjct: 482 TSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIV 541

Query: 522 VFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIP 571
            F    Y   G   +  W  + G ++       ++A++ +  A     +P
Sbjct: 542 TFRPPHY---GAYIFPDWANALGWVIATS----SMAMVPIYAAYKFCSLP 584


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  249 bits (635), Expect = 7e-66
 Identities = 110/211 (52%), Positives = 157/211 (74%), Gaps = 5/211 (2%)

Query: 1   MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60
           +E  RP W + LQ++ A + ++VGLGNVWRFPYLCQ  GGG++L+PY+I+L+V G+PL +
Sbjct: 57  VEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFF 116

Query: 61  LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120
           LEL+VGQR+R+GSIG W  ISP L G+G AS VV +F+++YYNVI  W+ +Y   SFQ P
Sbjct: 117 LELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQP 176

Query: 121 LPWSVCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAW 178
           LPW  CPL  N +HT  + ECE++S+T Y+WYR+ LNIS S+ E+GG+ W+  +CLL AW
Sbjct: 177 LPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAW 236

Query: 179 LVVYLCILRGTESTGKVVYFTASLPYCVLII 209
           ++V L +++G +S+GKV       P+ +L+I
Sbjct: 237 VMVCLAMIKGIQSSGKVSMLE---PFLILLI 264


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score =  140 bits (352), Expect = 4e-33
 Identities = 67/157 (42%), Positives = 93/157 (59%)

Query: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
           R  W++ + FV +     VGLGNVWRFPYLC   GGG+FL+PY I L   G+P+ +LE+ 
Sbjct: 41  REKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEII 100

Query: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
           +GQ   +G I  W  I P  SG+G ASVV+   L++YY VI AWA +YLF SFQ  LPW+
Sbjct: 101 IGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA 160

Query: 125 VCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQ 161
            C  + N     E+  + + + +     T   SP ++
Sbjct: 161 HCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIE 197


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.138    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,668,693
Number of Sequences: 37866
Number of extensions: 852658
Number of successful extensions: 2396
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2243
Number of HSP's gapped (non-prelim): 63
length of query: 592
length of database: 18,247,518
effective HSP length: 108
effective length of query: 484
effective length of database: 14,157,990
effective search space: 6852467160
effective search space used: 6852467160
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.