Search of human proteins with 110835710

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
sapiens]
         (1956 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ...  3935   0.0  
gi|150417967 voltage-gated sodium channel type V alpha isoform c...  2378   0.0  
gi|37622907 voltage-gated sodium channel type V alpha isoform a ...  2375   0.0  
gi|30089970 voltage-gated sodium channel type V alpha isoform b ...  2373   0.0  
gi|237512982 voltage-gated sodium channel type V alpha isoform f...  2355   0.0  
gi|150417969 voltage-gated sodium channel type V alpha isoform d...  2333   0.0  
gi|237512980 voltage-gated sodium channel type V alpha isoform e...  2309   0.0  
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor...  2118   0.0  
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor...  2118   0.0  
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor...  2116   0.0  
gi|126362947 sodium channel, voltage-gated, type III, alpha isof...  2110   0.0  
gi|126362955 sodium channel, voltage-gated, type III, alpha isof...  2108   0.0  
gi|126362949 sodium channel, voltage-gated, type III, alpha isof...  2105   0.0  
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ...  2097   0.0  
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...  2082   0.0  
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo...  2059   0.0  
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi...  1557   0.0  
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo...  1332   0.0  
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom...  1040   0.0  
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated...  1000   0.0  
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I...   523   e-148
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i...   426   e-118
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i...   426   e-118
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i...   426   e-118
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...   425   e-118
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...   425   e-118
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...   425   e-118
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i...   425   e-118
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i...   424   e-118
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...   423   e-118

>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
            sapiens]
          Length = 1956

 Score = 3935 bits (10205), Expect = 0.0
 Identities = 1956/1956 (100%), Positives = 1956/1956 (100%)

Query: 1    MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKAC 60
            MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKAC
Sbjct: 1    MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKAC 60

Query: 61   NQLPKFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIR 120
            NQLPKFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIR
Sbjct: 61   NQLPKFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIR 120

Query: 121  RTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFCLN 180
            RTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFCLN
Sbjct: 121  RTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFCLN 180

Query: 181  EFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALI 240
            EFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALI
Sbjct: 181  EFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALI 240

Query: 241  HSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYIN 300
            HSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYIN
Sbjct: 241  HSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYIN 300

Query: 301  KRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWER 360
            KRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWER
Sbjct: 301  KRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWER 360

Query: 361  LYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQE 420
            LYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQE
Sbjct: 361  LYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQE 420

Query: 421  ALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSD 480
            ALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSD
Sbjct: 421  ALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSD 480

Query: 481  PYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLG 540
            PYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLG
Sbjct: 481  PYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLG 540

Query: 541  GGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEY 600
            GGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEY
Sbjct: 541  GGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEY 600

Query: 601  LDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFG 660
            LDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFG
Sbjct: 601  LDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFG 660

Query: 661  LVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFD 720
            LVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFD
Sbjct: 661  LVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFD 720

Query: 721  PYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKII 780
            PYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKII
Sbjct: 721  PYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKII 780

Query: 781  GNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFL 840
            GNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFL
Sbjct: 781  GNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFL 840

Query: 841  IVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTA 900
            IVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTA
Sbjct: 841  IVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTA 900

Query: 901  PEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAEN 960
            PEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAEN
Sbjct: 901  PEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAEN 960

Query: 961  HIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSF 1020
            HIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSF
Sbjct: 961  HIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSF 1020

Query: 1021 QQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDD 1080
            QQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDD
Sbjct: 1021 QQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDD 1080

Query: 1081 TSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQ 1140
            TSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQ
Sbjct: 1081 TSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQ 1140

Query: 1141 VRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFE 1200
            VRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFE
Sbjct: 1141 VRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFE 1200

Query: 1201 MLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRA 1260
            MLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRA
Sbjct: 1201 MLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRA 1260

Query: 1261 LSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSL 1320
            LSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSL
Sbjct: 1261 LSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSL 1320

Query: 1321 VPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSR 1380
            VPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSR
Sbjct: 1321 VPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSR 1380

Query: 1381 EVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQK 1440
            EVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQK
Sbjct: 1381 EVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQK 1440

Query: 1441 KYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQ 1500
            KYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQ
Sbjct: 1441 KYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQ 1500

Query: 1501 SEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAIL 1560
            SEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAIL
Sbjct: 1501 SEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAIL 1560

Query: 1561 KSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFI 1620
            KSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFI
Sbjct: 1561 KSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFI 1620

Query: 1621 YSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDP 1680
            YSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDP
Sbjct: 1621 YSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDP 1680

Query: 1681 NLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDD 1740
            NLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDD
Sbjct: 1681 NLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDD 1740

Query: 1741 FDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHC 1800
            FDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHC
Sbjct: 1741 FDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHC 1800

Query: 1801 LDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQK 1860
            LDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQK
Sbjct: 1801 LDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQK 1860

Query: 1861 AYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPS 1920
            AYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPS
Sbjct: 1861 AYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPS 1920

Query: 1921 YESVTRGLSDRVNMRTSSSIQNEDEATSMELIAPGP 1956
            YESVTRGLSDRVNMRTSSSIQNEDEATSMELIAPGP
Sbjct: 1921 YESVTRGLSDRVNMRTSSSIQNEDEATSMELIAPGP 1956


>gi|150417967 voltage-gated sodium channel type V alpha isoform c
            [Homo sapiens]
          Length = 2016

 Score = 2378 bits (6163), Expect = 0.0
 Identities = 1262/2021 (62%), Positives = 1486/2021 (73%), Gaps = 112/2021 (5%)

Query: 10   TNNFRRFTPESLVEIEKQIAAKQGTKKAR-EKHREQKDQEEKPRPQLDLKACNQLPKFYG 68
            T++FRRFT ESL  IEK++A KQ       ++ RE   +EE PRPQLDL+A  +LP  YG
Sbjct: 10   TSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYG 69

Query: 69   ELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSV 128
              P ELIGEPLEDLDPFYST +TF+VLNKG+TI RFSAT AL++ SPF+ IRR A+K+ V
Sbjct: 70   NPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILV 129

Query: 129  HSWFSLFITVTILVNCVCMTRTDLP---EKIEYVFTVIYTFEALIKILARGFCLNEFTYL 185
            HS F++ I  TIL NCV M + D P   + +EY FT IYTFE+L+KILARGFCL+ FT+L
Sbjct: 130  HSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFL 189

Query: 186  RDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKK 245
            RDPWNWLDFSVI +AYV   I L  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKK
Sbjct: 190  RDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKK 249

Query: 246  LADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTN--------------YSS 291
            LADV +LT+FCLSVFAL+GLQLF GNL++KCV+N  A+N T                Y S
Sbjct: 250  LADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLS 309

Query: 292  HRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFR 351
               P+ Y+ K GTSD LLCGN SD+G CP+GY CLK  +NPD  YTSFDSFAWAFL+LFR
Sbjct: 310  D--PENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFR 367

Query: 352  LMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEI 411
            LMTQD WERLYQQTLR++GKIYMIFF+LVIFLGSFYLVNLILAVV MAYEEQNQAT  E 
Sbjct: 368  LMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAET 427

Query: 412  EAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGST 471
            E KEK+FQEA+EML+KE E L   G+DT S  S   SPL   N+ ERR + + R+S G+ 
Sbjct: 428  EEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTE 487

Query: 472  E--DNKSPRSDPYN-QRRMSFLGLASG------KRRASHGSVFHFRSPGRDISLPEGVTD 522
            E  +++ P+SD  +  R M+ L L  G      K R+S GS+F FR   RD+       D
Sbjct: 488  ECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR--RDLGSEADFAD 545

Query: 523  D-GVFPGDHESHRGSLLLG------GGAGQQGPLPRSP-------------------LPQ 556
            D     G+ ESH  SLL+          GQ  P   +P                   L  
Sbjct: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLG 605

Query: 557  PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLD---EPFRAQRAMSV 613
              +P++         P   E  P     S    G +     A  +D   EP   QRA+S 
Sbjct: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665

Query: 614  VSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITL 673
            VS++TS LEELEES  KCPPC   L+Q+YLIW+CCP+W+ +K  +  +V DPF +LTIT+
Sbjct: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725

Query: 674  CIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFD 733
            CIV+NT+FMA+EH+ M+  FE MLQ+GN+VFT  FTAEM FKIIA DPYYYFQ+ WNIFD
Sbjct: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785

Query: 734  CIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTII 793
             IIV +SL+ELG+++  +LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT++
Sbjct: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845

Query: 794  LAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIEN 853
            LAIIVF+FA+VG QL G+NY   R + S      PRWHM DFFH+FLI+FRILCGEWIE 
Sbjct: 846  LAIIVFIFAVVGMQLFGKNYSELRDSDSGL---LPRWHMMDFFHAFLIIFRILCGEWIET 902

Query: 854  MWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVA 913
            MW CMEV  +S+CL++FL VMV+GNLVVLNLF+ALLL+SFSADNLTAP++D E+NNLQ+A
Sbjct: 903  MWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLA 962

Query: 914  LARIQV---FGHRTKQALCSFFSRSCPFPQPKA-----EPELVVKLPLSSSKAENHIAAN 965
            LARIQ    F  RT    C    R  P  +P A     +    +  P S    E      
Sbjct: 963  LARIQRGLRFVKRTTWDFCCGLLRQRP-QKPAALAAQGQLPSCIATPYSPPPPETEKVPP 1021

Query: 966  TAR------GSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDD-----GG 1014
            T +      G   G   P  P              V VPIA  ESD DD E+D     G 
Sbjct: 1022 TRKETRFEEGEQPGQGTPGDPEP------------VCVPIAVAESDTDDQEEDEENSLGT 1069

Query: 1015 EDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVP 1074
            E+  S QQE  P     +     R    ++  +     +S   A    + WK E  PQ P
Sbjct: 1070 EEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQA-DWRQQWKAE--PQAP 1126

Query: 1075 AEG-VDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKS 1133
              G   + S SEGST D  +  E+L +IP+L  D+++P+DCFTEGC+R CPCC +DTT++
Sbjct: 1127 GCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQA 1186

Query: 1134 PWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVF 1193
            P  V W++RKTCY IVEHSWFE+FIIFMILLSSG+LAFED YL+++ T+K LLEY D++F
Sbjct: 1187 PGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMF 1246

Query: 1194 TFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLR 1253
            T++FV EMLLKWVAYGFKKYFTNAWCWLDFLIV++SL+SL A  L ++E+ PIK+LRTLR
Sbjct: 1247 TYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLR 1306

Query: 1254 ALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINY 1313
            ALRPLRALSRFEGMRVVV+ALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF RCIN 
Sbjct: 1307 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQ 1366

Query: 1314 TDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIM 1373
            T+G+  L   +IVNNKS C+  N TG  +W  VKVNFDNV  GYLALLQVATFKGWMDIM
Sbjct: 1367 TEGDLPL-NYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425

Query: 1374 YAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDI 1433
            YAAVDSR    QP+WE N+YMY+YFVIFIIFG FFTLNLF+GVIIDNFNQQKKKLGGQDI
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485

Query: 1434 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITM 1493
            FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK+QGF+FDIVT+QAFD+TIM LICLNM+TM
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTM 1545

Query: 1494 MVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIAS 1553
            MVETDDQS EK  IL KIN  FVA+FTGEC++K+ ALR YYFTN WN+FDF+VV+LSI  
Sbjct: 1546 MVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVG 1605

Query: 1554 LIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLL 1613
             + S I++    +FSPTLFRVIRLARIGRILRLIR AKGIRTLLFALMMSLPALFNIGLL
Sbjct: 1606 TVLSDIIQKY--FFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLL 1663

Query: 1614 LFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1673
            LFLVMFIYSIFGM++F +V+WEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT
Sbjct: 1664 LFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1723

Query: 1674 GPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEEST 1733
            GPPYCDP LPNSNG+RGDCGSPAVGI+FFTTYIIISFLI+VNMYIA+ILENF+VATEEST
Sbjct: 1724 GPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEEST 1783

Query: 1734 EPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLV 1793
            EPLSEDDFDMFYE WEKFDPEATQFI +S LSDFAD LS PLRI KPN+  LI MDLP+V
Sbjct: 1784 EPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMV 1843

Query: 1794 PGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDI 1853
             GD+IHC+DILFAFTK VLGESGE+D+LK  MEEKFMA N SK SYEPI TTLR K E++
Sbjct: 1844 SGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEV 1903

Query: 1854 SATVIQKAYRSYVLHRSMALSNTPCVPRA-----EEEAASLPDEGFVAFTANENC---VL 1905
            SA VIQ+A+R ++L RS+  ++     +A     EE+A     EG +A+  +EN    + 
Sbjct: 1904 SAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPE--REGLIAYVMSENFSRPLG 1961

Query: 1906 PDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEA 1946
            P  S + S+TSFPPSY+SVTR  SD + +R S    +ED A
Sbjct: 1962 PPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLA 2002


>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
            sapiens]
          Length = 2016

 Score = 2375 bits (6156), Expect = 0.0
 Identities = 1260/2021 (62%), Positives = 1485/2021 (73%), Gaps = 112/2021 (5%)

Query: 10   TNNFRRFTPESLVEIEKQIAAKQGTKKAR-EKHREQKDQEEKPRPQLDLKACNQLPKFYG 68
            T++FRRFT ESL  IEK++A KQ       ++ RE   +EE PRPQLDL+A  +LP  YG
Sbjct: 10   TSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYG 69

Query: 69   ELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSV 128
              P ELIGEPLEDLDPFYST +TF+VLNKG+TI RFSAT AL++ SPF+ IRR A+K+ V
Sbjct: 70   NPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILV 129

Query: 129  HSWFSLFITVTILVNCVCMTRTDLP---EKIEYVFTVIYTFEALIKILARGFCLNEFTYL 185
            HS F++ I  TIL NCV M + D P   + +EY FT IYTFE+L+KILARGFCL+ FT+L
Sbjct: 130  HSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFL 189

Query: 186  RDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKK 245
            RDPWNWLDFSVI +AY    +DL  +S LRTFRVLRALKT+SVI GLK IVGALI SVKK
Sbjct: 190  RDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKK 249

Query: 246  LADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTN--------------YSS 291
            LADV +LT+FCLSVFAL+GLQLF GNL++KCV+N  A+N T                Y S
Sbjct: 250  LADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLS 309

Query: 292  HRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFR 351
               P+ Y+ K GTSD LLCGN SD+G CP+GY CLK  +NPD  YTSFDSFAWAFL+LFR
Sbjct: 310  D--PENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFR 367

Query: 352  LMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEI 411
            LMTQD WERLYQQTLR++GKIYMIFF+LVIFLGSFYLVNLILAVV MAYEEQNQAT  E 
Sbjct: 368  LMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAET 427

Query: 412  EAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGST 471
            E KEK+FQEA+EML+KE E L   G+DT S  S   SPL   N+ ERR + + R+S G+ 
Sbjct: 428  EEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTE 487

Query: 472  E--DNKSPRSDPYN-QRRMSFLGLASG------KRRASHGSVFHFRSPGRDISLPEGVTD 522
            E  +++ P+SD  +  R M+ L L  G      K R+S GS+F FR   RD+       D
Sbjct: 488  ECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR--RDLGSEADFAD 545

Query: 523  D-GVFPGDHESHRGSLLLG------GGAGQQGPLPRSP-------------------LPQ 556
            D     G+ ESH  SLL+          GQ  P   +P                   L  
Sbjct: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLG 605

Query: 557  PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLD---EPFRAQRAMSV 613
              +P++         P   E  P     S    G +     A  +D   EP   QRA+S 
Sbjct: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665

Query: 614  VSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITL 673
            VS++TS LEELEES  KCPPC   L+Q+YLIW+CCP+W+ +K  +  +V DPF +LTIT+
Sbjct: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725

Query: 674  CIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFD 733
            CIV+NT+FMA+EH+ M+  FE MLQ+GN+VFT  FTAEM FKIIA DPYYYFQ+ WNIFD
Sbjct: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785

Query: 734  CIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTII 793
             IIV +SL+ELG+++  +LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT++
Sbjct: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845

Query: 794  LAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIEN 853
            LAIIVF+FA+VG QL G+NY   R + S      PRWHM DFFH+FLI+FRILCGEWIE 
Sbjct: 846  LAIIVFIFAVVGMQLFGKNYSELRDSDSGL---LPRWHMMDFFHAFLIIFRILCGEWIET 902

Query: 854  MWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVA 913
            MW CMEV  +S+CL++FL VMV+GNLVVLNLF+ALLL+SFSADNLTAP++D E+NNLQ+A
Sbjct: 903  MWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLA 962

Query: 914  LARIQV---FGHRTKQALCSFFSRSCPFPQPKA-----EPELVVKLPLSSSKAENHIAAN 965
            LARIQ    F  RT    C    R  P  +P A     +    +  P S    E      
Sbjct: 963  LARIQRGLRFVKRTTWDFCCGLLRQRP-QKPAALAAQGQLPSCIATPYSPPPPETEKVPP 1021

Query: 966  TAR------GSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDD-----GG 1014
            T +      G   G   P  P              V VPIA  ESD DD E+D     G 
Sbjct: 1022 TRKETRFEEGEQPGQGTPGDPEP------------VCVPIAVAESDTDDQEEDEENSLGT 1069

Query: 1015 EDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVP 1074
            E+  S QQE  P     +     R    ++  +     +S   A    + WK E  PQ P
Sbjct: 1070 EEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQA-DWRQQWKAE--PQAP 1126

Query: 1075 AEG-VDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKS 1133
              G   + S SEGST D  +  E+L +IP+L  D+++P+DCFTEGC+R CPCC +DTT++
Sbjct: 1127 GCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQA 1186

Query: 1134 PWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVF 1193
            P  V W++RKTCY IVEHSWFE+FIIFMILLSSG+LAFED YL+++ T+K LLEY D++F
Sbjct: 1187 PGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMF 1246

Query: 1194 TFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLR 1253
            T++FV EMLLKWVAYGFKKYFTNAWCWLDFLIV++SL+SL A  L ++E+ PIK+LRTLR
Sbjct: 1247 TYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLR 1306

Query: 1254 ALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINY 1313
            ALRPLRALSRFEGMRVVV+ALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF RCIN 
Sbjct: 1307 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQ 1366

Query: 1314 TDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIM 1373
            T+G+  L   +IVNNKS C+  N TG  +W  VKVNFDNV  GYLALLQVATFKGWMDIM
Sbjct: 1367 TEGDLPL-NYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425

Query: 1374 YAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDI 1433
            YAAVDSR    QP+WE N+YMY+YFVIFIIFG FFTLNLF+GVIIDNFNQQKKKLGGQDI
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485

Query: 1434 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITM 1493
            FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK+QGF+FDIVT+QAFD+TIM LICLNM+TM
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTM 1545

Query: 1494 MVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIAS 1553
            MVETDDQS EK  IL KIN  FVA+FTGEC++K+ ALR YYFTN WN+FDF+VV+LSI  
Sbjct: 1546 MVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVG 1605

Query: 1554 LIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLL 1613
             + S I++    +FSPTLFRVIRLARIGRILRLIR AKGIRTLLFALMMSLPALFNIGLL
Sbjct: 1606 TVLSDIIQKY--FFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLL 1663

Query: 1614 LFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1673
            LFLVMFIYSIFGM++F +V+WEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT
Sbjct: 1664 LFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1723

Query: 1674 GPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEEST 1733
            GPPYCDP LPNSNG+RGDCGSPAVGI+FFTTYIIISFLI+VNMYIA+ILENF+VATEEST
Sbjct: 1724 GPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEEST 1783

Query: 1734 EPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLV 1793
            EPLSEDDFDMFYE WEKFDPEATQFI +S LSDFAD LS PLRI KPN+  LI MDLP+V
Sbjct: 1784 EPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMV 1843

Query: 1794 PGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDI 1853
             GD+IHC+DILFAFTK VLGESGE+D+LK  MEEKFMA N SK SYEPI TTLR K E++
Sbjct: 1844 SGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEV 1903

Query: 1854 SATVIQKAYRSYVLHRSMALSNTPCVPRA-----EEEAASLPDEGFVAFTANENC---VL 1905
            SA VIQ+A+R ++L RS+  ++     +A     EE+A     EG +A+  +EN    + 
Sbjct: 1904 SAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPE--REGLIAYVMSENFSRPLG 1961

Query: 1906 PDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEA 1946
            P  S + S+TSFPPSY+SVTR  SD + +R S    +ED A
Sbjct: 1962 PPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLA 2002


>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
            sapiens]
          Length = 2015

 Score = 2373 bits (6150), Expect = 0.0
 Identities = 1258/2020 (62%), Positives = 1485/2020 (73%), Gaps = 111/2020 (5%)

Query: 10   TNNFRRFTPESLVEIEKQIAAKQGTKKAR-EKHREQKDQEEKPRPQLDLKACNQLPKFYG 68
            T++FRRFT ESL  IEK++A KQ       ++ RE   +EE PRPQLDL+A  +LP  YG
Sbjct: 10   TSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYG 69

Query: 69   ELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSV 128
              P ELIGEPLEDLDPFYST +TF+VLNKG+TI RFSAT AL++ SPF+ IRR A+K+ V
Sbjct: 70   NPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILV 129

Query: 129  HSWFSLFITVTILVNCVCMTRTDLP---EKIEYVFTVIYTFEALIKILARGFCLNEFTYL 185
            HS F++ I  TIL NCV M + D P   + +EY FT IYTFE+L+KILARGFCL+ FT+L
Sbjct: 130  HSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFL 189

Query: 186  RDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKK 245
            RDPWNWLDFSVI +AY    +DL  +S LRTFRVLRALKT+SVI GLK IVGALI SVKK
Sbjct: 190  RDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKK 249

Query: 246  LADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTN--------------YSS 291
            LADV +LT+FCLSVFAL+GLQLF GNL++KCV+N  A+N T                Y S
Sbjct: 250  LADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLS 309

Query: 292  HRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFR 351
               P+ Y+ K GTSD LLCGN SD+G CP+GY CLK  +NPD  YTSFDSFAWAFL+LFR
Sbjct: 310  D--PENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFR 367

Query: 352  LMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEI 411
            LMTQD WERLYQQTLR++GKIYMIFF+LVIFLGSFYLVNLILAVV MAYEEQNQAT  E 
Sbjct: 368  LMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAET 427

Query: 412  EAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGST 471
            E KEK+FQEA+EML+KE E L   G+DT S  S   SPL   N+ ERR + + R+S G+ 
Sbjct: 428  EEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTE 487

Query: 472  E--DNKSPRSDPYN-QRRMSFLGLASG------KRRASHGSVFHFRSPGRDISLPEGVTD 522
            E  +++ P+SD  +  R M+ L L  G      K R+S GS+F FR   RD+       D
Sbjct: 488  ECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR--RDLGSEADFAD 545

Query: 523  D-GVFPGDHESHRGSLLLG------GGAGQQGPLPRSP-------------------LPQ 556
            D     G+ ESH  SLL+          GQ  P   +P                   L  
Sbjct: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLG 605

Query: 557  PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLD---EPFRAQRAMSV 613
              +P++         P   E  P     S    G +     A  +D   EP   QRA+S 
Sbjct: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665

Query: 614  VSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITL 673
            VS++TS LEELEES  KCPPC   L+Q+YLIW+CCP+W+ +K  +  +V DPF +LTIT+
Sbjct: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725

Query: 674  CIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFD 733
            CIV+NT+FMA+EH+ M+  FE MLQ+GN+VFT  FTAEM FKIIA DPYYYFQ+ WNIFD
Sbjct: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785

Query: 734  CIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTII 793
             IIV +SL+ELG+++  +LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT++
Sbjct: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845

Query: 794  LAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIEN 853
            LAIIVF+FA+VG QL G+NY   R + S      PRWHM DFFH+FLI+FRILCGEWIE 
Sbjct: 846  LAIIVFIFAVVGMQLFGKNYSELRDSDSGL---LPRWHMMDFFHAFLIIFRILCGEWIET 902

Query: 854  MWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVA 913
            MW CMEV  +S+CL++FL VMV+GNLVVLNLF+ALLL+SFSADNLTAP++D E+NNLQ+A
Sbjct: 903  MWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLA 962

Query: 914  LARIQV---FGHRTKQALCSFFSRSCPFPQPKA-----EPELVVKLPLSSSKAENHIAAN 965
            LARIQ    F  RT    C    R  P  +P A     +    +  P S    E      
Sbjct: 963  LARIQRGLRFVKRTTWDFCCGLLRQRP-QKPAALAAQGQLPSCIATPYSPPPPETEKVPP 1021

Query: 966  TAR------GSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDG----GE 1015
            T +      G   G   P  P              V VPIA  ESD DD E+D     G 
Sbjct: 1022 TRKETRFEEGEQPGQGTPGDPEP------------VCVPIAVAESDTDDQEEDEENSLGT 1069

Query: 1016 DAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPA 1075
            + +S +QE  P     +     R    ++  +     +S   A    + WK E  PQ P 
Sbjct: 1070 EEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQA-DWRQQWKAE--PQAPG 1126

Query: 1076 EG-VDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSP 1134
             G   + S SEGST D  +  E+L +IP+L  D+++P+DCFTEGC+R CPCC +DTT++P
Sbjct: 1127 CGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAP 1186

Query: 1135 WDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFT 1194
              V W++RKTCY IVEHSWFE+FIIFMILLSSG+LAFED YL+++ T+K LLEY D++FT
Sbjct: 1187 GKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFT 1246

Query: 1195 FIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRA 1254
            ++FV EMLLKWVAYGFKKYFTNAWCWLDFLIV++SL+SL A  L ++E+ PIK+LRTLRA
Sbjct: 1247 YVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRA 1306

Query: 1255 LRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYT 1314
            LRPLRALSRFEGMRVVV+ALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF RCIN T
Sbjct: 1307 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQT 1366

Query: 1315 DGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMY 1374
            +G+  L   +IVNNKS C+  N TG  +W  VKVNFDNV  GYLALLQVATFKGWMDIMY
Sbjct: 1367 EGDLPL-NYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMY 1425

Query: 1375 AAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIF 1434
            AAVDSR    QP+WE N+YMY+YFVIFIIFG FFTLNLF+GVIIDNFNQQKKKLGGQDIF
Sbjct: 1426 AAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIF 1485

Query: 1435 MTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMM 1494
            MTEEQKKYYNAMKKLGSKKPQKPIPRPLNK+QGF+FDIVT+QAFD+TIM LICLNM+TMM
Sbjct: 1486 MTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMM 1545

Query: 1495 VETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASL 1554
            VETDDQS EK  IL KIN  FVA+FTGEC++K+ ALR YYFTN WN+FDF+VV+LSI   
Sbjct: 1546 VETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGT 1605

Query: 1555 IFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLL 1614
            + S I++    +FSPTLFRVIRLARIGRILRLIR AKGIRTLLFALMMSLPALFNIGLLL
Sbjct: 1606 VLSDIIQKY--FFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL 1663

Query: 1615 FLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTG 1674
            FLVMFIYSIFGM++F +V+WEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTG
Sbjct: 1664 FLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTG 1723

Query: 1675 PPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTE 1734
            PPYCDP LPNSNG+RGDCGSPAVGI+FFTTYIIISFLI+VNMYIA+ILENF+VATEESTE
Sbjct: 1724 PPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1783

Query: 1735 PLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVP 1794
            PLSEDDFDMFYE WEKFDPEATQFI +S LSDFAD LS PLRI KPN+  LI MDLP+V 
Sbjct: 1784 PLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVS 1843

Query: 1795 GDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDIS 1854
            GD+IHC+DILFAFTK VLGESGE+D+LK  MEEKFMA N SK SYEPI TTLR K E++S
Sbjct: 1844 GDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVS 1903

Query: 1855 ATVIQKAYRSYVLHRSMALSNTPCVPRA-----EEEAASLPDEGFVAFTANENC---VLP 1906
            A VIQ+A+R ++L RS+  ++     +A     EE+A     EG +A+  +EN    + P
Sbjct: 1904 AMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPE--REGLIAYVMSENFSRPLGP 1961

Query: 1907 DKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEA 1946
              S + S+TSFPPSY+SVTR  SD + +R S    +ED A
Sbjct: 1962 PSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLA 2001


>gi|237512982 voltage-gated sodium channel type V alpha isoform f
            [Homo sapiens]
          Length = 1962

 Score = 2355 bits (6104), Expect = 0.0
 Identities = 1253/2015 (62%), Positives = 1471/2015 (73%), Gaps = 154/2015 (7%)

Query: 10   TNNFRRFTPESLVEIEKQIAAKQGTKKAR-EKHREQKDQEEKPRPQLDLKACNQLPKFYG 68
            T++FRRFT ESL  IEK++A KQ       ++ RE   +EE PRPQLDL+A  +LP  YG
Sbjct: 10   TSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYG 69

Query: 69   ELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSV 128
              P ELIGEPLEDLDPFYST +TF+VLNKG+TI RFSAT AL++ SPF+ IRR A+K+ V
Sbjct: 70   NPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILV 129

Query: 129  HSWFSLFITVTILVNCVCMTRTDLP---EKIEYVFTVIYTFEALIKILARGFCLNEFTYL 185
            HS F++ I  TIL NCV M + D P   + +EY FT IYTFE+L+KILARGFCL+ FT+L
Sbjct: 130  HSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFL 189

Query: 186  RDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKK 245
            RDPWNWLDFSVI +AYV   I L  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKK
Sbjct: 190  RDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKK 249

Query: 246  LADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTN--------------YSS 291
            LADV +LT+FCLSVFAL+GLQLF GNL++KCV+N  A+N T                Y S
Sbjct: 250  LADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLS 309

Query: 292  HRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFR 351
               P+ Y+ K GTSD LLCGN SD+G CP+GY CLK  +NPD  YTSFDSFAWAFL+LFR
Sbjct: 310  D--PENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFR 367

Query: 352  LMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEI 411
            LMTQD WERLYQQTLR++GKIYMIFF+LVIFLGSFYLVNLILAVV MAYEEQNQAT  E 
Sbjct: 368  LMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAET 427

Query: 412  EAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGST 471
            E KEK+FQEA+EML+KE E L   G+DT S  S   SPL   N+ ERR + + R+S G+ 
Sbjct: 428  EEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTE 487

Query: 472  E--DNKSPRSDPYN-QRRMSFLGLASG------KRRASHGSVFHFRSPGRDISLPEGVTD 522
            E  +++ P+SD  +  R M+ L L  G      K R+S GS+F FR   RD+       D
Sbjct: 488  ECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR--RDLGSEADFAD 545

Query: 523  D-GVFPGDHESHRGSLLLG------GGAGQQGPLPRSP-------------------LPQ 556
            D     G+ ESH  SLL+          GQ  P   +P                   L  
Sbjct: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLG 605

Query: 557  PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLD---EPFRAQRAMSV 613
              +P++         P   E  P     S    G +     A  +D   EP   QRA+S 
Sbjct: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665

Query: 614  VSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITL 673
            VS++TS LEELEES  KCPPC   L+Q+YLIW+CCP+W+ +K  +  +V DPF +LTIT+
Sbjct: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725

Query: 674  CIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFD 733
            CIV+NT+FMA+EH+ M+  FE MLQ+GN+VFT  FTAEM FKIIA DPYYYFQ+ WNIFD
Sbjct: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785

Query: 734  CIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTII 793
             IIV +SL+ELG+++  +LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT++
Sbjct: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845

Query: 794  LAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIEN 853
            LAIIVF+FA+VG QL G+NY   R + S      PRWHM DFFH+FLI+FRILCGEWIE 
Sbjct: 846  LAIIVFIFAVVGMQLFGKNYSELRDSDSGL---LPRWHMMDFFHAFLIIFRILCGEWIET 902

Query: 854  MWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVA 913
            MW CMEV  +S+CL++FL VMV+GNLVVLNLF+ALLL+SFSADNLTAP++D E+NNLQ+A
Sbjct: 903  MWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLA 962

Query: 914  LARIQV---FGHRTKQALCSFFSRSCPFPQPKA-----EPELVVKLPLSSSKAENHIAAN 965
            LARIQ    F  RT    C    R  P  +P A     +    +  P S    E      
Sbjct: 963  LARIQRGLRFVKRTTWDFCCGLLRQRP-QKPAALAAQGQLPSCIATPYSPPPPETEKVPP 1021

Query: 966  TAR------GSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQS 1019
            T +      G   G   P  P              V VPIA  ESD DD E         
Sbjct: 1022 TRKETRFEEGEQPGQGTPGDPEP------------VCVPIAVAESDTDDQE--------- 1060

Query: 1020 FQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVD 1079
                                               ED   SLG   ++ES  Q P +   
Sbjct: 1061 -----------------------------------EDEENSLGT--EEESSKQTPED--- 1080

Query: 1080 DTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGW 1139
              S SEGST D  +  E+L +IP+L  D+++P+DCFTEGC+R CPCC +DTT++P  V W
Sbjct: 1081 --SCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWW 1138

Query: 1140 QVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVF 1199
            ++RKTCY IVEHSWFE+FIIFMILLSSG+LAFED YL+++ T+K LLEY D++FT++FV 
Sbjct: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1198

Query: 1200 EMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLR 1259
            EMLLKWVAYGFKKYFTNAWCWLDFLIV++SL+SL A  L ++E+ PIK+LRTLRALRPLR
Sbjct: 1199 EMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLR 1258

Query: 1260 ALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFS 1319
            ALSRFEGMRVVV+ALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF RCIN T+G+  
Sbjct: 1259 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLP 1318

Query: 1320 LVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDS 1379
            L   +IVNNKS C+  N TG  +W  VKVNFDNV  GYLALLQVATFKGWMDIMYAAVDS
Sbjct: 1319 L-NYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1377

Query: 1380 REVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQ 1439
            R    QP+WE N+YMY+YFVIFIIFG FFTLNLF+GVIIDNFNQQKKKLGGQDIFMTEEQ
Sbjct: 1378 RGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQ 1437

Query: 1440 KKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDD 1499
            KKYYNAMKKLGSKKPQKPIPRPLNK+QGF+FDIVT+QAFD+TIM LICLNM+TMMVETDD
Sbjct: 1438 KKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDD 1497

Query: 1500 QSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAI 1559
            QS EK  IL KIN  FVA+FTGEC++K+ ALR YYFTN WN+FDF+VV+LSI   + S I
Sbjct: 1498 QSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDI 1557

Query: 1560 LKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1619
            ++    +FSPTLFRVIRLARIGRILRLIR AKGIRTLLFALMMSLPALFNIGLLLFLVMF
Sbjct: 1558 IQKY--FFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1615

Query: 1620 IYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCD 1679
            IYSIFGM++F +V+WEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCD
Sbjct: 1616 IYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCD 1675

Query: 1680 PNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSED 1739
            P LPNSNG+RGDCGSPAVGI+FFTTYIIISFLI+VNMYIA+ILENF+VATEESTEPLSED
Sbjct: 1676 PTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSED 1735

Query: 1740 DFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIH 1799
            DFDMFYE WEKFDPEATQFI +S LSDFAD LS PLRI KPN+  LI MDLP+V GD+IH
Sbjct: 1736 DFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIH 1795

Query: 1800 CLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQ 1859
            C+DILFAFTK VLGESGE+D+LK  MEEKFMA N SK SYEPI TTLR K E++SA VIQ
Sbjct: 1796 CMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQ 1855

Query: 1860 KAYRSYVLHRSMALSNTPCVPRA-----EEEAASLPDEGFVAFTANENC---VLPDKSET 1911
            +A+R ++L RS+  ++     +A     EE+A     EG +A+  +EN    + P  S +
Sbjct: 1856 RAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPE--REGLIAYVMSENFSRPLGPPSSSS 1913

Query: 1912 ASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEA 1946
             S+TSFPPSY+SVTR  SD + +R S    +ED A
Sbjct: 1914 ISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLA 1948


>gi|150417969 voltage-gated sodium channel type V alpha isoform d
            [Homo sapiens]
          Length = 1998

 Score = 2333 bits (6045), Expect = 0.0
 Identities = 1245/2021 (61%), Positives = 1469/2021 (72%), Gaps = 130/2021 (6%)

Query: 10   TNNFRRFTPESLVEIEKQIAAKQGTKKAR-EKHREQKDQEEKPRPQLDLKACNQLPKFYG 68
            T++FRRFT ESL  IEK++A KQ       ++ RE   +EE PRPQLDL+A  +LP  YG
Sbjct: 10   TSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYG 69

Query: 69   ELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSV 128
              P ELIGEPLEDLDPFYST +TF+VLNKG+TI RFSAT AL++ SPF+ IRR A+K+ V
Sbjct: 70   NPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILV 129

Query: 129  HSWFSLFITVTILVNCVCMTRTDLP---EKIEYVFTVIYTFEALIKILARGFCLNEFTYL 185
            HS F++ I  TIL NCV M + D P   + +EY FT IYTFE+L+KILARGFCL+ FT+L
Sbjct: 130  HSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFL 189

Query: 186  RDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKK 245
            RDPWNWLDFSVI +AYV   I L  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKK
Sbjct: 190  RDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKK 249

Query: 246  LADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTN--------------YSS 291
            LADV +LT+FCLSVFAL+GLQLF GNL++KCV+N  A+N T                Y S
Sbjct: 250  LADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLS 309

Query: 292  HRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFR 351
               P+ Y+ K GTSD LLCGN SD+G CP+GY CLK  +NPD  YTSFDSFAWAFL+LFR
Sbjct: 310  D--PENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFR 367

Query: 352  LMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEI 411
            LMTQD WERLYQQTLR++GKIYMIFF+LVIFLGSFYLVNLILAVV MAYEEQNQAT  E 
Sbjct: 368  LMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAET 427

Query: 412  EAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGST 471
            E KEK+FQEA+EML+KE E L   G+DT S  S   SPL   N+ ERR + + R+S G+ 
Sbjct: 428  EEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTE 487

Query: 472  E--DNKSPRSDPYN-QRRMSFLGLASG------KRRASHGSVFHFRSPGRDISLPEGVTD 522
            E  +++ P+SD  +  R M+ L L  G      K R+S GS+F FR   RD+       D
Sbjct: 488  ECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR--RDLGSEADFAD 545

Query: 523  D-GVFPGDHESHRGSLLLG------GGAGQQGPLPRSP-------------------LPQ 556
            D     G+ ESH  SLL+          GQ  P   +P                   L  
Sbjct: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLG 605

Query: 557  PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLD---EPFRAQRAMSV 613
              +P++         P   E  P     S    G +     A  +D   EP   QRA+S 
Sbjct: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665

Query: 614  VSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITL 673
            VS++TS LEELEES  KCPPC   L+Q+YLIW+CCP+W+ +K  +  +V DPF +LTIT+
Sbjct: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725

Query: 674  CIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFD 733
            CIV+NT+FMA+EH+ M+  FE MLQ+GN+VFT  FTAEM FKIIA DPYYYFQ+ WNIFD
Sbjct: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785

Query: 734  CIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTII 793
             IIV +SL+ELG+++  +LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT++
Sbjct: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845

Query: 794  LAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIEN 853
            LAIIVF+FA+VG QL G+NY   R + S      PRWHM DFFH+FLI+FRILCGEWIE 
Sbjct: 846  LAIIVFIFAVVGMQLFGKNYSELRDSDSGL---LPRWHMMDFFHAFLIIFRILCGEWIET 902

Query: 854  MWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVA 913
            MW CMEV  +S+CL++FL VMV+GNLVVLNLF+ALLL+SFSADNLTAP++D E+NNLQ+A
Sbjct: 903  MWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLA 962

Query: 914  LARIQV---FGHRTKQALCSFFSRSCPFPQPKA-----EPELVVKLPLSSSKAENHIAAN 965
            LARIQ    F  RT    C    R  P  +P A     +    +  P S    E      
Sbjct: 963  LARIQRGLRFVKRTTWDFCCGLLRQRP-QKPAALAAQGQLPSCIATPYSPPPPETEKVPP 1021

Query: 966  TAR------GSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDD-----GG 1014
            T +      G   G   P  P              V VPIA  ESD DD E+D     G 
Sbjct: 1022 TRKETRFEEGEQPGQGTPGDPEP------------VCVPIAVAESDTDDQEEDEENSLGT 1069

Query: 1015 EDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVP 1074
            E+  S QQE  P     +     R    ++  +     +S   A    + WK E  PQ P
Sbjct: 1070 EEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQA-DWRQQWKAE--PQAP 1126

Query: 1075 AEG-VDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKS 1133
              G   + S SEGST D  +  E+L +IP+L  D+++P+DCFTEGC+R CPCC +DTT++
Sbjct: 1127 GCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQA 1186

Query: 1134 PWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVF 1193
            P  V W++RKTCY IVEHSWFE+FIIFMILLSSG+LAFED YL+++ T+K LLEY D++F
Sbjct: 1187 PGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMF 1246

Query: 1194 TFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLR 1253
            T++FV EMLLKWVAYGFKKYFTNAWCWLDFLIV++SL+SL A  L ++E+ PIK+LRTLR
Sbjct: 1247 TYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLR 1306

Query: 1254 ALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINY 1313
            ALRPLRALSRFEGMRVVV+ALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF RCIN 
Sbjct: 1307 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQ 1366

Query: 1314 TDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIM 1373
            T+G+  L   +IVNNKS C+  N TG  +W  VKVNFDNV  GYLALLQV          
Sbjct: 1367 TEGDLPL-NYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV---------- 1415

Query: 1374 YAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDI 1433
                       QP+WE N+YMY+YFVIFIIFG FFTLNLF+GVIIDNFNQQKKKLGGQDI
Sbjct: 1416 --------YEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1467

Query: 1434 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITM 1493
            FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK+QGF+FDIVT+QAFD+TIM LICLNM+TM
Sbjct: 1468 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTM 1527

Query: 1494 MVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIAS 1553
            MVETDDQS EK  IL KIN  FVA+FTGEC++K+ ALR YYFTN WN+FDF+VV+LSI  
Sbjct: 1528 MVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVG 1587

Query: 1554 LIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLL 1613
             + S I++    +FSPTLFRVIRLARIGRILRLIR AKGIRTLLFALMMSLPALFNIGLL
Sbjct: 1588 TVLSDIIQKY--FFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLL 1645

Query: 1614 LFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1673
            LFLVMFIYSIFGM++F +V+WEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT
Sbjct: 1646 LFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1705

Query: 1674 GPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEEST 1733
            GPPYCDP LPNSNG+RGDCGSPAVGI+FFTTYIIISFLI+VNMYIA+ILENF+VATEEST
Sbjct: 1706 GPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEEST 1765

Query: 1734 EPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLV 1793
            EPLSEDDFDMFYE WEKFDPEATQFI +S LSDFAD LS PLRI KPN+  LI MDLP+V
Sbjct: 1766 EPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMV 1825

Query: 1794 PGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDI 1853
             GD+IHC+DILFAFTK VLGESGE+D+LK  MEEKFMA N SK SYEPI TTLR K E++
Sbjct: 1826 SGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEV 1885

Query: 1854 SATVIQKAYRSYVLHRSMALSNTPCVPRA-----EEEAASLPDEGFVAFTANENC---VL 1905
            SA VIQ+A+R ++L RS+  ++     +A     EE+A     EG +A+  +EN    + 
Sbjct: 1886 SAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPE--REGLIAYVMSENFSRPLG 1943

Query: 1906 PDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEA 1946
            P  S + S+TSFPPSY+SVTR  SD + +R S    +ED A
Sbjct: 1944 PPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLA 1984


>gi|237512980 voltage-gated sodium channel type V alpha isoform e
            [Homo sapiens]
          Length = 1983

 Score = 2309 bits (5984), Expect = 0.0
 Identities = 1240/2020 (61%), Positives = 1458/2020 (72%), Gaps = 143/2020 (7%)

Query: 10   TNNFRRFTPESLVEIEKQIAAKQGTKKAR-EKHREQKDQEEKPRPQLDLKACNQLPKFYG 68
            T++FRRFT ESL  IEK++A KQ       ++ RE   +EE PRPQLDL+A  +LP  YG
Sbjct: 10   TSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYG 69

Query: 69   ELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSV 128
              P ELIGEPLEDLDPFYST +TF+VLNKG+TI RFSAT AL++ SPF+ IRR A+K+ V
Sbjct: 70   NPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILV 129

Query: 129  HSWFSLFITVTILVNCVCMTRTDLP---EKIEYVFTVIYTFEALIKILARGFCLNEFTYL 185
            HS F++ I  TIL NCV M + D P   + +EY FT IYTFE+L+KILARGFCL+ FT+L
Sbjct: 130  HSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFL 189

Query: 186  RDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKK 245
            RDPWNWLDFSVI +AYV   I L  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKK
Sbjct: 190  RDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKK 249

Query: 246  LADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTN--------------YSS 291
            LADV +LT+FCLSVFAL+GLQLF GNL++KCV+N  A+N T                Y S
Sbjct: 250  LADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLS 309

Query: 292  HRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFR 351
               P+ Y+ K GTSD LLCGN SD+G CP+GY CLK  +NPD  YTSFDSFAWAFL+LFR
Sbjct: 310  D--PENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFR 367

Query: 352  LMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEI 411
            LMTQD WERLYQQTLR++GKIYMIFF+LVIFLGSFYLVNLILAVV MAYEEQNQAT  E 
Sbjct: 368  LMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAET 427

Query: 412  EAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGST 471
            E KEK+FQEA+EML+KE E L   G+DT S  S   SPL   N+ ERR + + R+S G+ 
Sbjct: 428  EEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTE 487

Query: 472  E--DNKSPRSDPYN-QRRMSFLGLASG------KRRASHGSVFHFRSPGRDISLPEGVTD 522
            E  +++ P+SD  +  R M+ L L  G      K R+S GS+F FR   RD+       D
Sbjct: 488  ECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR--RDLGSEADFAD 545

Query: 523  D-GVFPGDHESHRGSLLLG------GGAGQQGPLPRSP-------------------LPQ 556
            D     G+ ESH  SLL+          GQ  P   +P                   L  
Sbjct: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLG 605

Query: 557  PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLD---EPFRAQRAMSV 613
              +P++         P   E  P     S    G +     A  +D   EP   QRA+S 
Sbjct: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665

Query: 614  VSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITL 673
            VS++TS LEELEES  KCPPC   L+Q+YLIW+CCP+W+ +K  +  +V DPF +LTIT+
Sbjct: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725

Query: 674  CIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFD 733
            CIV+NT+FMA+EH+ M+  FE MLQ+GN+VFT  FTAEM FKIIA DPYYYFQ+ WNIFD
Sbjct: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785

Query: 734  CIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTII 793
             IIV +SL+ELG+++  +LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT++
Sbjct: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845

Query: 794  LAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIEN 853
            LAIIVF+FA+VG QL G+NY   R + S      PRWHM DFFH+FLI+FRILCGEWIE 
Sbjct: 846  LAIIVFIFAVVGMQLFGKNYSELRDSDSGL---LPRWHMMDFFHAFLIIFRILCGEWIET 902

Query: 854  MWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVA 913
            MW CMEV  +S+CL++FL VMV+GNLVVLNLF+ALLL+SFSADNLTAP++D E+NNLQ+A
Sbjct: 903  MWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLA 962

Query: 914  LARIQV---FGHRTKQALCSFFSRSCPFPQPKA-----EPELVVKLPLSSSKAENHIAAN 965
            LARIQ    F  RT    C    R  P  +P A     +    +  P S    E      
Sbjct: 963  LARIQRGLRFVKRTTWDFCCGLLRQRP-QKPAALAAQGQLPSCIATPYSPPPPETEKVPP 1021

Query: 966  TAR------GSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDG----GE 1015
            T +      G   G   P  P              V VPIA  ESD DD E+D     G 
Sbjct: 1022 TRKETRFEEGEQPGQGTPGDPEP------------VCVPIAVAESDTDDQEEDEENSLGT 1069

Query: 1016 DAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPA 1075
            + +S +QE  P     +     R    ++  +     +S   A    + WK E  PQ P 
Sbjct: 1070 EEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQA-DWRQQWKAE--PQAPG 1126

Query: 1076 EG-VDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSP 1134
             G   + S SEGST D  +  E+L +IP+L  D+++P+DCFTEGC+R CPCC +DTT++P
Sbjct: 1127 CGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAP 1186

Query: 1135 WDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFT 1194
              V W++RKTCY IVEHSWFE+FIIFMILLSSG+LAFED YL+++ T+K LLEY D++FT
Sbjct: 1187 GKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFT 1246

Query: 1195 FIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRA 1254
            ++FV EMLLKWVAYGFKKYFTNAWCWLDFLIV++SL+SL A  L ++E+ PIK+LRTLRA
Sbjct: 1247 YVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRA 1306

Query: 1255 LRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYT 1314
            LRPLRALSRFEGMRVVV+ALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF RCIN T
Sbjct: 1307 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQT 1366

Query: 1315 DGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMY 1374
            +G+  L   +IVNNKS C+  N TG  +W  VKVNFDNV  GYLALLQVATFKGWMDIMY
Sbjct: 1367 EGDLPL-NYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMY 1425

Query: 1375 AAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIF 1434
            AAVDSR    QP+WE N+YMY+YFVIFIIFG FFTLNLF+GVIIDNFNQQKKKLGGQDIF
Sbjct: 1426 AAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIF 1485

Query: 1435 MTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMM 1494
            MTEEQKKYYNAMKKLGSKKPQKPIPRPLNK+QGF+FDIVT+QAFD+TIM LICLNM+TMM
Sbjct: 1486 MTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMM 1545

Query: 1495 VETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASL 1554
            VETDDQS EK  IL KIN  FVA+FTG  +  +    Q YF                   
Sbjct: 1546 VETDDQSPEKINILAKINLLFVAIFTGTVLSDII---QKYF------------------- 1583

Query: 1555 IFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLL 1614
                        FSPTLFRVIRLARIGRILRLIR AKGIRTLLFALMMSLPALFNIGLLL
Sbjct: 1584 ------------FSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL 1631

Query: 1615 FLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTG 1674
            FLVMFIYSIFGM++F +V+WEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTG
Sbjct: 1632 FLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTG 1691

Query: 1675 PPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTE 1734
            PPYCDP LPNSNG+RGDCGSPAVGI+FFTTYIIISFLI+VNMYIA+ILENF+VATEESTE
Sbjct: 1692 PPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1751

Query: 1735 PLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVP 1794
            PLSEDDFDMFYE WEKFDPEATQFI +S LSDFAD LS PLRI KPN+  LI MDLP+V 
Sbjct: 1752 PLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVS 1811

Query: 1795 GDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDIS 1854
            GD+IHC+DILFAFTK VLGESGE+D+LK  MEEKFMA N SK SYEPI TTLR K E++S
Sbjct: 1812 GDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVS 1871

Query: 1855 ATVIQKAYRSYVLHRSMALSNTPCVPRA-----EEEAASLPDEGFVAFTANENC---VLP 1906
            A VIQ+A+R ++L RS+  ++     +A     EE+A     EG +A+  +EN    + P
Sbjct: 1872 AMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPE--REGLIAYVMSENFSRPLGP 1929

Query: 1907 DKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEA 1946
              S + S+TSFPPSY+SVTR  SD + +R S    +ED A
Sbjct: 1930 PSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLA 1969


>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 2118 bits (5488), Expect = 0.0
 Identities = 1144/2032 (56%), Positives = 1413/2032 (69%), Gaps = 179/2032 (8%)

Query: 11   NNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGEL 70
            ++FR FT ESL  IE++IA ++  +  +E  R+ +D E  P+P  DL+A   LP  YG++
Sbjct: 12   DSFRFFTRESLAAIEQRIAEEKAKRPKQE--RKDEDDENGPKPNSDLEAGKSLPFIYGDI 69

Query: 71   PAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHS 130
            P E++  PLEDLDP+Y   +TF+VLNKG+ ISRFSAT AL++ +PFN IR+ AIK+ VHS
Sbjct: 70   PPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHS 129

Query: 131  WFSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLRD 187
             F++ I  TIL NCV MT ++ P+    +EY FT IYTFE+LIKILARGFCL +FT+LRD
Sbjct: 130  LFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRD 189

Query: 188  PWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLA 247
            PWNWLDF+VIT AYV   +DL  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL+
Sbjct: 190  PWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLS 249

Query: 248  DVTILTIFCLSVFALVGLQLFKGNLKNKCVK-----NDMAVNETTNYSSHRKP------- 295
            DV ILT+FCLSVFAL+GLQLF GNL+NKC++     +   +N T+ +++           
Sbjct: 250  DVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNR 309

Query: 296  -------DIYINKR-------GTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDS 341
                   D YI  +       G +D LLCGN SD+G CP+GYIC+K   NP++ YTSFD+
Sbjct: 310  TVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDT 369

Query: 342  FAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYE 401
            F+WAFLSLFRLMTQD WE LYQ TLR +GK YMIFFVLVIFLGSFYL+NLILAVV MAYE
Sbjct: 370  FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYE 429

Query: 402  EQNQATTDEIEAKEKKFQEALEMLRKEQEVLAAL---------------GIDTTSLHSHN 446
            EQNQAT +E E KE +FQ+ LE L+K+QE   A                GI   S  S  
Sbjct: 430  EQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSV 489

Query: 447  GSPLTSKNASE-RRHRIKPRVSEGSTEDNKSPR--------------------------- 478
             S L+SK+  E +  R K +  E S E+ K+ R                           
Sbjct: 490  ASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSRLTYE 549

Query: 479  ---SDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESH 533
               S P+ Q  +S  G     RR S  S+F FR   +DI       DD    F  D++S 
Sbjct: 550  KRFSSPH-QSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFE-DNDSR 607

Query: 534  RGSLLLGGGAGQ-------QGPLPRSPLP-QPSNPDSRHGEDEHQP------PPT----S 575
            R SL +    G+       Q       LP  P N       D +        P T     
Sbjct: 608  RDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAG 667

Query: 576  ELAP-GAVDVSAFDAGQKKTF-LSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPP 633
            +L P G    +     +  ++ +S + L++P   QRAMS+ SI+T+ +EELEES QKCPP
Sbjct: 668  QLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPP 727

Query: 634  CLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTF 693
            C    +   LIWDCC  W+K+K ++  +V DPF +L IT+CIV+NT+FMAMEH+ M+  F
Sbjct: 728  CWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQF 787

Query: 694  EAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLS 753
             ++L +GN+VFT  FTAEM  KIIA DPYYYFQ+ WNIFD  IV++SL+ELG+A    LS
Sbjct: 788  SSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLS 847

Query: 754  VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENY 813
            VLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y
Sbjct: 848  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 907

Query: 814  RNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTV 873
            +     IS   E  PRWHMHDFFHSFLIVFR+LCGEWIE MW CMEV  +++CL +F+ V
Sbjct: 908  KECVCKISNDCE-LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMV 966

Query: 874  MVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFS 933
            MV+GNLVVLNLF+ALLL+SFS+DNL A +DD E+NNLQ+A+ R+Q      K+ +  F  
Sbjct: 967  MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQ 1026

Query: 934  RSCPFPQPKAEPELVVKLPLSSSK---AENHIAA-------------NTARGSSGGLQAP 977
            ++    Q KA  E+     L++ K     NH                 T  G    ++  
Sbjct: 1027 KAFVRKQ-KALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKY 1085

Query: 978  RGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVE 1037
                 ++  FI NP++ V+VPIA GESD ++L                            
Sbjct: 1086 VVDESDYMSFINNPSLTVTVPIAVGESDFENLNT-------------------------- 1119

Query: 1038 RCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEI 1097
                                     E +  ES  +   E ++ TSSSEGSTVD   P E 
Sbjct: 1120 -------------------------EEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEG 1154

Query: 1098 LRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESF 1157
             +   E  + L EP+ CFTE C+R   CC++   +    + W +RKTCY+IVEH+WFE+F
Sbjct: 1155 EQPEVEPEESL-EPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETF 1213

Query: 1158 IIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNA 1217
            I+FMILLSSG+LAFED Y++Q+ T+K +LEY D+VFT+IF+ EMLLKWVAYGF+ YFTNA
Sbjct: 1214 IVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNA 1273

Query: 1218 WCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGA 1277
            WCWLDFLIV++SL+SLTA  L YSE+  IK+LRTLRALRPLRALSRFEGMRVVV+AL+GA
Sbjct: 1274 WCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGA 1333

Query: 1278 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCK-IQN 1336
            IPSIMNVLLVCLIFWLIFSIMGVNLFAGKF+ CINYT GE  +  +S+VNN S+CK +  
Sbjct: 1334 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGE--MFDVSVVNNYSECKALIE 1391

Query: 1337 STGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYL 1396
            S  +  W NVKVNFDNV +GYL+LLQVATFKGWMDIMYAAVDSR V +QPK+EDN+YMYL
Sbjct: 1392 SNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYL 1451

Query: 1397 YFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1456
            YFVIFIIFG FFTLNLF+GVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQK
Sbjct: 1452 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511

Query: 1457 PIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFV 1516
            PIPRP NKFQG VFD VT+Q FDI+IM+LICLNM+TMMVETDDQS+E T IL  IN  F+
Sbjct: 1512 PIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFI 1571

Query: 1517 AVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIR 1576
             +FTGECV+K+ +LR YYFT GWN+FDF+VV+LSI  +  + +++  + + SPTLFRVIR
Sbjct: 1572 VLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIE--KYFVSPTLFRVIR 1629

Query: 1577 LARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEA 1636
            LARIGRILRLI+ AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+ E 
Sbjct: 1630 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREV 1689

Query: 1637 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPN-SNGTRGDCGSP 1695
            GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+GPP CDP+  +  +  +GDCG+P
Sbjct: 1690 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNP 1749

Query: 1696 AVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEA 1755
            +VGI FF +YIIISFL++VNMYIAVILENF+VATEES EPLSEDDF+MFYE WEKFDP+A
Sbjct: 1750 SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1809

Query: 1756 TQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGES 1815
            TQFI F+ LSDFAD L  PL I KPN+  LI MDLP+V GD+IHCLDILFAFTK VLGES
Sbjct: 1810 TQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGES 1869

Query: 1816 GELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSN 1875
            GE+D+L+  MEE+FMA+N SK SYEPI TTL+ KQE++SA +IQ+AYR Y+L + +   +
Sbjct: 1870 GEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVS 1929

Query: 1876 TPCVPRAEEEAASLP-DEGFVAFTANENCVLPDKSETASATSFPPSYESVTR 1926
            +       +E    P  E  +    NEN   P+K++   +T+ PPSY+SVT+
Sbjct: 1930 SIYKKDKGKECDGTPIKEDTLIDKLNENST-PEKTDMTPSTTSPPSYDSVTK 1980


>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 2118 bits (5488), Expect = 0.0
 Identities = 1144/2032 (56%), Positives = 1413/2032 (69%), Gaps = 179/2032 (8%)

Query: 11   NNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGEL 70
            ++FR FT ESL  IE++IA ++  +  +E  R+ +D E  P+P  DL+A   LP  YG++
Sbjct: 12   DSFRFFTRESLAAIEQRIAEEKAKRPKQE--RKDEDDENGPKPNSDLEAGKSLPFIYGDI 69

Query: 71   PAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHS 130
            P E++  PLEDLDP+Y   +TF+VLNKG+ ISRFSAT AL++ +PFN IR+ AIK+ VHS
Sbjct: 70   PPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHS 129

Query: 131  WFSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLRD 187
             F++ I  TIL NCV MT ++ P+    +EY FT IYTFE+LIKILARGFCL +FT+LRD
Sbjct: 130  LFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRD 189

Query: 188  PWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLA 247
            PWNWLDF+VIT AYV   +DL  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL+
Sbjct: 190  PWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLS 249

Query: 248  DVTILTIFCLSVFALVGLQLFKGNLKNKCVK-----NDMAVNETTNYSSHRKP------- 295
            DV ILT+FCLSVFAL+GLQLF GNL+NKC++     +   +N T+ +++           
Sbjct: 250  DVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNR 309

Query: 296  -------DIYINKR-------GTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDS 341
                   D YI  +       G +D LLCGN SD+G CP+GYIC+K   NP++ YTSFD+
Sbjct: 310  TVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDT 369

Query: 342  FAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYE 401
            F+WAFLSLFRLMTQD WE LYQ TLR +GK YMIFFVLVIFLGSFYL+NLILAVV MAYE
Sbjct: 370  FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYE 429

Query: 402  EQNQATTDEIEAKEKKFQEALEMLRKEQEVLAAL---------------GIDTTSLHSHN 446
            EQNQAT +E E KE +FQ+ LE L+K+QE   A                GI   S  S  
Sbjct: 430  EQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSV 489

Query: 447  GSPLTSKNASE-RRHRIKPRVSEGSTEDNKSPR--------------------------- 478
             S L+SK+  E +  R K +  E S E+ K+ R                           
Sbjct: 490  ASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSRLTYE 549

Query: 479  ---SDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESH 533
               S P+ Q  +S  G     RR S  S+F FR   +DI       DD    F  D++S 
Sbjct: 550  KRFSSPH-QSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFE-DNDSR 607

Query: 534  RGSLLLGGGAGQ-------QGPLPRSPLP-QPSNPDSRHGEDEHQP------PPT----S 575
            R SL +    G+       Q       LP  P N       D +        P T     
Sbjct: 608  RDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAG 667

Query: 576  ELAP-GAVDVSAFDAGQKKTF-LSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPP 633
            +L P G    +     +  ++ +S + L++P   QRAMS+ SI+T+ +EELEES QKCPP
Sbjct: 668  QLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPP 727

Query: 634  CLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTF 693
            C    +   LIWDCC  W+K+K ++  +V DPF +L IT+CIV+NT+FMAMEH+ M+  F
Sbjct: 728  CWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQF 787

Query: 694  EAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLS 753
             ++L +GN+VFT  FTAEM  KIIA DPYYYFQ+ WNIFD  IV++SL+ELG+A    LS
Sbjct: 788  SSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLS 847

Query: 754  VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENY 813
            VLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y
Sbjct: 848  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 907

Query: 814  RNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTV 873
            +     IS   E  PRWHMHDFFHSFLIVFR+LCGEWIE MW CMEV  +++CL +F+ V
Sbjct: 908  KECVCKISNDCE-LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMV 966

Query: 874  MVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFS 933
            MV+GNLVVLNLF+ALLL+SFS+DNL A +DD E+NNLQ+A+ R+Q      K+ +  F  
Sbjct: 967  MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQ 1026

Query: 934  RSCPFPQPKAEPELVVKLPLSSSK---AENHIAA-------------NTARGSSGGLQAP 977
            ++    Q KA  E+     L++ K     NH                 T  G    ++  
Sbjct: 1027 KAFVRKQ-KALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKY 1085

Query: 978  RGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVE 1037
                 ++  FI NP++ V+VPIA GESD ++L                            
Sbjct: 1086 VVDESDYMSFINNPSLTVTVPIAVGESDFENLNT-------------------------- 1119

Query: 1038 RCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEI 1097
                                     E +  ES  +   E ++ TSSSEGSTVD   P E 
Sbjct: 1120 -------------------------EEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEG 1154

Query: 1098 LRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESF 1157
             +   E  + L EP+ CFTE C+R   CC++   +    + W +RKTCY+IVEH+WFE+F
Sbjct: 1155 EQPEVEPEESL-EPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETF 1213

Query: 1158 IIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNA 1217
            I+FMILLSSG+LAFED Y++Q+ T+K +LEY D+VFT+IF+ EMLLKWVAYGF+ YFTNA
Sbjct: 1214 IVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNA 1273

Query: 1218 WCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGA 1277
            WCWLDFLIV++SL+SLTA  L YSE+  IK+LRTLRALRPLRALSRFEGMRVVV+AL+GA
Sbjct: 1274 WCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGA 1333

Query: 1278 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCK-IQN 1336
            IPSIMNVLLVCLIFWLIFSIMGVNLFAGKF+ CINYT GE  +  +S+VNN S+CK +  
Sbjct: 1334 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGE--MFDVSVVNNYSECKALIE 1391

Query: 1337 STGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYL 1396
            S  +  W NVKVNFDNV +GYL+LLQVATFKGWMDIMYAAVDSR V +QPK+EDN+YMYL
Sbjct: 1392 SNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYL 1451

Query: 1397 YFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1456
            YFVIFIIFG FFTLNLF+GVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQK
Sbjct: 1452 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511

Query: 1457 PIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFV 1516
            PIPRP NKFQG VFD VT+Q FDI+IM+LICLNM+TMMVETDDQS+E T IL  IN  F+
Sbjct: 1512 PIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFI 1571

Query: 1517 AVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIR 1576
             +FTGECV+K+ +LR YYFT GWN+FDF+VV+LSI  +  + +++  + + SPTLFRVIR
Sbjct: 1572 VLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIE--KYFVSPTLFRVIR 1629

Query: 1577 LARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEA 1636
            LARIGRILRLI+ AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+ E 
Sbjct: 1630 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREV 1689

Query: 1637 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPN-SNGTRGDCGSP 1695
            GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+GPP CDP+  +  +  +GDCG+P
Sbjct: 1690 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNP 1749

Query: 1696 AVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEA 1755
            +VGI FF +YIIISFL++VNMYIAVILENF+VATEES EPLSEDDF+MFYE WEKFDP+A
Sbjct: 1750 SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1809

Query: 1756 TQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGES 1815
            TQFI F+ LSDFAD L  PL I KPN+  LI MDLP+V GD+IHCLDILFAFTK VLGES
Sbjct: 1810 TQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGES 1869

Query: 1816 GELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSN 1875
            GE+D+L+  MEE+FMA+N SK SYEPI TTL+ KQE++SA +IQ+AYR Y+L + +   +
Sbjct: 1870 GEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVS 1929

Query: 1876 TPCVPRAEEEAASLP-DEGFVAFTANENCVLPDKSETASATSFPPSYESVTR 1926
            +       +E    P  E  +    NEN   P+K++   +T+ PPSY+SVT+
Sbjct: 1930 SIYKKDKGKECDGTPIKEDTLIDKLNENST-PEKTDMTPSTTSPPSYDSVTK 1980


>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
            [Homo sapiens]
          Length = 2005

 Score = 2116 bits (5483), Expect = 0.0
 Identities = 1143/2032 (56%), Positives = 1413/2032 (69%), Gaps = 179/2032 (8%)

Query: 11   NNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGEL 70
            ++FR FT ESL  IE++IA ++  +  +E  R+ +D E  P+P  DL+A   LP  YG++
Sbjct: 12   DSFRFFTRESLAAIEQRIAEEKAKRPKQE--RKDEDDENGPKPNSDLEAGKSLPFIYGDI 69

Query: 71   PAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHS 130
            P E++  PLEDLDP+Y   +TF+VLNKG+ ISRFSAT AL++ +PFN IR+ AIK+ VHS
Sbjct: 70   PPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHS 129

Query: 131  WFSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLRD 187
             F++ I  TIL NCV MT ++ P+    +EY FT IYTFE+LIKILARGFCL +FT+LRD
Sbjct: 130  LFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRD 189

Query: 188  PWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLA 247
            PWNWLDF+VIT AYV   ++L  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL+
Sbjct: 190  PWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLS 249

Query: 248  DVTILTIFCLSVFALVGLQLFKGNLKNKCVK-----NDMAVNETTNYSSHRKP------- 295
            DV ILT+FCLSVFAL+GLQLF GNL+NKC++     +   +N T+ +++           
Sbjct: 250  DVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNR 309

Query: 296  -------DIYINKR-------GTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDS 341
                   D YI  +       G +D LLCGN SD+G CP+GYIC+K   NP++ YTSFD+
Sbjct: 310  TVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDT 369

Query: 342  FAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYE 401
            F+WAFLSLFRLMTQD WE LYQ TLR +GK YMIFFVLVIFLGSFYL+NLILAVV MAYE
Sbjct: 370  FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYE 429

Query: 402  EQNQATTDEIEAKEKKFQEALEMLRKEQEVLAAL---------------GIDTTSLHSHN 446
            EQNQAT +E E KE +FQ+ LE L+K+QE   A                GI   S  S  
Sbjct: 430  EQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSV 489

Query: 447  GSPLTSKNASE-RRHRIKPRVSEGSTEDNKSPR--------------------------- 478
             S L+SK+  E +  R K +  E S E+ K+ R                           
Sbjct: 490  ASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSRLTYE 549

Query: 479  ---SDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESH 533
               S P+ Q  +S  G     RR S  S+F FR   +DI       DD    F  D++S 
Sbjct: 550  KRFSSPH-QSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFE-DNDSR 607

Query: 534  RGSLLLGGGAGQ-------QGPLPRSPLP-QPSNPDSRHGEDEHQP------PPT----S 575
            R SL +    G+       Q       LP  P N       D +        P T     
Sbjct: 608  RDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAG 667

Query: 576  ELAP-GAVDVSAFDAGQKKTF-LSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPP 633
            +L P G    +     +  ++ +S + L++P   QRAMS+ SI+T+ +EELEES QKCPP
Sbjct: 668  QLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPP 727

Query: 634  CLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTF 693
            C    +   LIWDCC  W+K+K ++  +V DPF +L IT+CIV+NT+FMAMEH+ M+  F
Sbjct: 728  CWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQF 787

Query: 694  EAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLS 753
             ++L +GN+VFT  FTAEM  KIIA DPYYYFQ+ WNIFD  IV++SL+ELG+A    LS
Sbjct: 788  SSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLS 847

Query: 754  VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENY 813
            VLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y
Sbjct: 848  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 907

Query: 814  RNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTV 873
            +     IS   E  PRWHMHDFFHSFLIVFR+LCGEWIE MW CMEV  +++CL +F+ V
Sbjct: 908  KECVCKISNDCE-LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMV 966

Query: 874  MVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFS 933
            MV+GNLVVLNLF+ALLL+SFS+DNL A +DD E+NNLQ+A+ R+Q      K+ +  F  
Sbjct: 967  MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQ 1026

Query: 934  RSCPFPQPKAEPELVVKLPLSSSK---AENHIAA-------------NTARGSSGGLQAP 977
            ++    Q KA  E+     L++ K     NH                 T  G    ++  
Sbjct: 1027 KAFVRKQ-KALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKY 1085

Query: 978  RGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVE 1037
                 ++  FI NP++ V+VPIA GESD ++L                            
Sbjct: 1086 VVDESDYMSFINNPSLTVTVPIAVGESDFENLNT-------------------------- 1119

Query: 1038 RCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEI 1097
                                     E +  ES  +   E ++ TSSSEGSTVD   P E 
Sbjct: 1120 -------------------------EEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEG 1154

Query: 1098 LRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESF 1157
             +   E  + L EP+ CFTE C+R   CC++   +    + W +RKTCY+IVEH+WFE+F
Sbjct: 1155 EQPEVEPEESL-EPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETF 1213

Query: 1158 IIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNA 1217
            I+FMILLSSG+LAFED Y++Q+ T+K +LEY D+VFT+IF+ EMLLKWVAYGF+ YFTNA
Sbjct: 1214 IVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNA 1273

Query: 1218 WCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGA 1277
            WCWLDFLIV++SL+SLTA  L YSE+  IK+LRTLRALRPLRALSRFEGMRVVV+AL+GA
Sbjct: 1274 WCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGA 1333

Query: 1278 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCK-IQN 1336
            IPSIMNVLLVCLIFWLIFSIMGVNLFAGKF+ CINYT GE  +  +S+VNN S+CK +  
Sbjct: 1334 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGE--MFDVSVVNNYSECKALIE 1391

Query: 1337 STGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYL 1396
            S  +  W NVKVNFDNV +GYL+LLQVATFKGWMDIMYAAVDSR V +QPK+EDN+YMYL
Sbjct: 1392 SNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYL 1451

Query: 1397 YFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1456
            YFVIFIIFG FFTLNLF+GVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQK
Sbjct: 1452 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511

Query: 1457 PIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFV 1516
            PIPRP NKFQG VFD VT+Q FDI+IM+LICLNM+TMMVETDDQS+E T IL  IN  F+
Sbjct: 1512 PIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFI 1571

Query: 1517 AVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIR 1576
             +FTGECV+K+ +LR YYFT GWN+FDF+VV+LSI  +  + +++  + + SPTLFRVIR
Sbjct: 1572 VLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIE--KYFVSPTLFRVIR 1629

Query: 1577 LARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEA 1636
            LARIGRILRLI+ AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+ E 
Sbjct: 1630 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREV 1689

Query: 1637 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPN-SNGTRGDCGSP 1695
            GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+GPP CDP+  +  +  +GDCG+P
Sbjct: 1690 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNP 1749

Query: 1696 AVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEA 1755
            +VGI FF +YIIISFL++VNMYIAVILENF+VATEES EPLSEDDF+MFYE WEKFDP+A
Sbjct: 1750 SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1809

Query: 1756 TQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGES 1815
            TQFI F+ LSDFAD L  PL I KPN+  LI MDLP+V GD+IHCLDILFAFTK VLGES
Sbjct: 1810 TQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGES 1869

Query: 1816 GELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSN 1875
            GE+D+L+  MEE+FMA+N SK SYEPI TTL+ KQE++SA +IQ+AYR Y+L + +   +
Sbjct: 1870 GEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVS 1929

Query: 1876 TPCVPRAEEEAASLP-DEGFVAFTANENCVLPDKSETASATSFPPSYESVTR 1926
            +       +E    P  E  +    NEN   P+K++   +T+ PPSY+SVT+
Sbjct: 1930 SIYKKDKGKECDGTPIKEDTLIDKLNENST-PEKTDMTPSTTSPPSYDSVTK 1980


>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
            [Homo sapiens]
          Length = 1951

 Score = 2110 bits (5467), Expect = 0.0
 Identities = 1128/2008 (56%), Positives = 1397/2008 (69%), Gaps = 187/2008 (9%)

Query: 12   NFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGELP 71
            +FR FT ESL  IEK+ A ++  K  +E   +  D E KP+P  DL+A   LP  YG++P
Sbjct: 13   SFRLFTRESLAAIEKRAAEEKAKKPKKE---QDNDDENKPKPNSDLEAGKNLPFIYGDIP 69

Query: 72   AELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSW 131
             E++ EPLEDLDP+Y   +TF+V+NKG+ I RFSAT AL++ +P N +R+ AIK+ VHS 
Sbjct: 70   PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129

Query: 132  FSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLRDP 188
            FS+ I  TIL NCV MT ++ P+    +EY FT IYTFE+LIKILARGFCL +FT+LRDP
Sbjct: 130  FSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDP 189

Query: 189  WNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLAD 248
            WNWLDFSVI +AYV   +DL  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL+D
Sbjct: 190  WNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSD 249

Query: 249  VTILTIFCLSVFALVGLQLFKGNLKNKCVK----------------------NDMAVN-- 284
            V ILT+FCLSVFAL+GLQLF GNL+NKC++                      N   VN  
Sbjct: 250  VMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVT 309

Query: 285  -ETTNYSSHRKPDIYINKR-GTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSF 342
              T N+  +   D +     G  DPLLCGNGSD+G CP+GYIC+K   NP++ YTSFD+F
Sbjct: 310  MSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTF 369

Query: 343  AWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEE 402
            +WAFLSLFRLMTQD WE LYQ TLR +GK YMIFFVLVIFLGSFYLVNLILAVV MAYEE
Sbjct: 370  SWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEE 429

Query: 403  QNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNG--------------S 448
            QNQAT +E E KE +FQ+ LE L+K+QE   A+   + +    +G              S
Sbjct: 430  QNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEAS 489

Query: 449  PLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQ-------RRMSFLGLASGKR---- 497
             L+SK+A E R+R K R      E N     D + +       +R SFL    G R    
Sbjct: 490  KLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSD 549

Query: 498  ---------------------RASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESHR 534
                                 R S  S+F FR   +D+       DD    F  D ES R
Sbjct: 550  KKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFE-DSESRR 608

Query: 535  GSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKT 594
             SL +                       RHGE  +    T+E       +S++       
Sbjct: 609  DSLFV---------------------PHRHGERRNSNGTTTETEVRKRRLSSYQ------ 641

Query: 595  FLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKL 654
             +S E L++    QRA+S+ SI+T+ +EELEES QKCPPC    +  +LIWDCC  W+K+
Sbjct: 642  -ISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKV 700

Query: 655  KTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVF 714
            K ++  +V DPF +L IT+CIV+NT+FMAMEH+ M+  F ++L +GN+VFT  FTAEMV 
Sbjct: 701  KHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVL 760

Query: 715  KIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLN 774
            KIIA DPYYYFQ+ WNIFD IIV++SL+ELG++    LSVLRSFRLLRVFKLAKSWPTLN
Sbjct: 761  KIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLN 820

Query: 775  TLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHED--WPRWHM 832
             LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y   ++ +   ++D   PRWHM
Sbjct: 821  MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY---KECVCKINDDCTLPRWHM 877

Query: 833  HDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNS 892
            +DFFHSFLIVFR+LCGEWIE MW CMEV  +++CLI+F+ VMV+GNLVVLNLF+ALLL+S
Sbjct: 878  NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSS 937

Query: 893  FSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKA--------- 943
            FS+DNL A +DD E+NNLQ+A+ R+Q      K  +   F ++  F +PK          
Sbjct: 938  FSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAF-FRKPKVIEIHEGNKI 996

Query: 944  EPELVVKLPLSSSKAENHI--AANTARGSSGGLQAPRGPRDE--HSDFIANPTVWVSVPI 999
            +  +     +  SK  N++     T  G   G    +   DE  +  FI NP++ V+VPI
Sbjct: 997  DSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPI 1056

Query: 1000 AEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAP 1059
            A GESD ++L                                                  
Sbjct: 1057 AVGESDFENLNT------------------------------------------------ 1068

Query: 1060 SLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGC 1119
               E +  ES  +   E ++ TSSSEGSTVD + P E  +   E  +DL +P+ CFTEGC
Sbjct: 1069 ---EEFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDL-KPEACFTEGC 1124

Query: 1120 IRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQK 1179
            I+  P C++ T +    + W +RKTCY IVEH+WFE+FI+FMILLSSG+LAFED Y++Q+
Sbjct: 1125 IKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQR 1184

Query: 1180 PTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILE 1239
             T+K +LEY D+VFT+IF+ EMLLKWVAYGF+ YFTNAWCWLDFLIV++SL+SL A  L 
Sbjct: 1185 KTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALG 1244

Query: 1240 YSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMG 1299
            YSE+  IK+LRTLRALRPLRALSRFEGMRVVV+ALVGAIPSIMNVLLVCLIFWLIFSIMG
Sbjct: 1245 YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMG 1304

Query: 1300 VNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLA 1359
            VNLFAGKF+ C+N T G  ++  +S VNN SDC+         W NVKVNFDNV  GYLA
Sbjct: 1305 VNLFAGKFYHCVNMTTG--NMFDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLA 1360

Query: 1360 LLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIID 1419
            LLQVATFKGWMDIMYAAVDSR+V +QP +E+N+YMYLYFVIFIIFG FFTLNLF+GVIID
Sbjct: 1361 LLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIID 1420

Query: 1420 NFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFD 1479
            NFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NKFQG VFD VTRQ FD
Sbjct: 1421 NFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFD 1480

Query: 1480 ITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGW 1539
            I+IM+LICLNM+TMMVETDDQ +  T +L +IN  F+ +FTGE V+K+ +LR YYFT GW
Sbjct: 1481 ISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGW 1540

Query: 1540 NVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFA 1599
            N+FDF+VV+LSI  +  + +++  + + SPTLFRVIRLARIGRILRLI+ AKGIRTLLFA
Sbjct: 1541 NIFDFVVVILSIVGMFLAEMIE--KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFA 1598

Query: 1600 LMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITT 1659
            LMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+ EAGIDDMFNF+TF NSM+CLFQITT
Sbjct: 1599 LMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITT 1658

Query: 1660 SAGWDGLLSPILNTGPPYCDPN-LPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYI 1718
            SAGWDGLL+PILN+ PP CDP+ +   +  +GDCG+P+VGI FF +YIIISFL++VNMYI
Sbjct: 1659 SAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYI 1718

Query: 1719 AVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIP 1778
            AVILENF+VATEES EPLSEDDF+MFYE WEKFDP+ATQFI FS LSDFA  L  PL I 
Sbjct: 1719 AVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIA 1778

Query: 1779 KPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSS 1838
            KPN+  LI MDLP+V GD+IHCLDILFAFTK VLGESGE+D+L+  ME++FMA+N SK S
Sbjct: 1779 KPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVS 1838

Query: 1839 YEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFT 1898
            YEPI TTL+ KQE++SA +IQ+ +R Y+L + +   ++     A +    LP +  +   
Sbjct: 1839 YEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIID 1898

Query: 1899 ANENCVLPDKSETASATSFPPSYESVTR 1926
                   P+K++ +S+T+ PPSY+SVT+
Sbjct: 1899 KLNGNSTPEKTDGSSSTTSPPSYDSVTK 1926


>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
            [Homo sapiens]
          Length = 1951

 Score = 2108 bits (5461), Expect = 0.0
 Identities = 1127/2008 (56%), Positives = 1396/2008 (69%), Gaps = 187/2008 (9%)

Query: 12   NFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGELP 71
            +FR FT ESL  IEK+ A ++  K  +E   +  D E KP+P  DL+A   LP  YG++P
Sbjct: 13   SFRLFTRESLAAIEKRAAEEKAKKPKKE---QDNDDENKPKPNSDLEAGKNLPFIYGDIP 69

Query: 72   AELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSW 131
             E++ EPLEDLDP+Y   +TF+V+NKG+ I RFSAT AL++ +P N +R+ AIK+ VHS 
Sbjct: 70   PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129

Query: 132  FSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLRDP 188
            FS+ I  TIL NCV MT ++ P+    +EY FT IYTFE+LIKILARGFCL +FT+LRDP
Sbjct: 130  FSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDP 189

Query: 189  WNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLAD 248
            WNWLDFSVI +AYV   + L  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL+D
Sbjct: 190  WNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSD 249

Query: 249  VTILTIFCLSVFALVGLQLFKGNLKNKCVK----------------------NDMAVN-- 284
            V ILT+FCLSVFAL+GLQLF GNL+NKC++                      N   VN  
Sbjct: 250  VMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVT 309

Query: 285  -ETTNYSSHRKPDIYINKR-GTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSF 342
              T N+  +   D +     G  DPLLCGNGSD+G CP+GYIC+K   NP++ YTSFD+F
Sbjct: 310  MSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTF 369

Query: 343  AWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEE 402
            +WAFLSLFRLMTQD WE LYQ TLR +GK YMIFFVLVIFLGSFYLVNLILAVV MAYEE
Sbjct: 370  SWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEE 429

Query: 403  QNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNG--------------S 448
            QNQAT +E E KE +FQ+ LE L+K+QE   A+   + +    +G              S
Sbjct: 430  QNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEAS 489

Query: 449  PLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQ-------RRMSFLGLASGKR---- 497
             L+SK+A E R+R K R      E N     D + +       +R SFL    G R    
Sbjct: 490  KLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSD 549

Query: 498  ---------------------RASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESHR 534
                                 R S  S+F FR   +D+       DD    F  D ES R
Sbjct: 550  KKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFE-DSESRR 608

Query: 535  GSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKT 594
             SL +                       RHGE  +    T+E       +S++       
Sbjct: 609  DSLFV---------------------PHRHGERRNSNGTTTETEVRKRRLSSYQ------ 641

Query: 595  FLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKL 654
             +S E L++    QRA+S+ SI+T+ +EELEES QKCPPC    +  +LIWDCC  W+K+
Sbjct: 642  -ISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKV 700

Query: 655  KTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVF 714
            K ++  +V DPF +L IT+CIV+NT+FMAMEH+ M+  F ++L +GN+VFT  FTAEMV 
Sbjct: 701  KHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVL 760

Query: 715  KIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLN 774
            KIIA DPYYYFQ+ WNIFD IIV++SL+ELG++    LSVLRSFRLLRVFKLAKSWPTLN
Sbjct: 761  KIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLN 820

Query: 775  TLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHED--WPRWHM 832
             LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y   ++ +   ++D   PRWHM
Sbjct: 821  MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY---KECVCKINDDCTLPRWHM 877

Query: 833  HDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNS 892
            +DFFHSFLIVFR+LCGEWIE MW CMEV  +++CLI+F+ VMV+GNLVVLNLF+ALLL+S
Sbjct: 878  NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSS 937

Query: 893  FSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKA--------- 943
            FS+DNL A +DD E+NNLQ+A+ R+Q      K  +   F ++  F +PK          
Sbjct: 938  FSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAF-FRKPKVIEIHEGNKI 996

Query: 944  EPELVVKLPLSSSKAENHI--AANTARGSSGGLQAPRGPRDE--HSDFIANPTVWVSVPI 999
            +  +     +  SK  N++     T  G   G    +   DE  +  FI NP++ V+VPI
Sbjct: 997  DSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPI 1056

Query: 1000 AEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAP 1059
            A GESD ++L                                                  
Sbjct: 1057 AVGESDFENLNT------------------------------------------------ 1068

Query: 1060 SLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGC 1119
               E +  ES  +   E ++ TSSSEGSTVD + P E  +   E  +DL +P+ CFTEGC
Sbjct: 1069 ---EEFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDL-KPEACFTEGC 1124

Query: 1120 IRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQK 1179
            I+  P C++ T +    + W +RKTCY IVEH+WFE+FI+FMILLSSG+LAFED Y++Q+
Sbjct: 1125 IKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQR 1184

Query: 1180 PTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILE 1239
             T+K +LEY D+VFT+IF+ EMLLKWVAYGF+ YFTNAWCWLDFLIV++SL+SL A  L 
Sbjct: 1185 KTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALG 1244

Query: 1240 YSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMG 1299
            YSE+  IK+LRTLRALRPLRALSRFEGMRVVV+ALVGAIPSIMNVLLVCLIFWLIFSIMG
Sbjct: 1245 YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMG 1304

Query: 1300 VNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLA 1359
            VNLFAGKF+ C+N T G  ++  +S VNN SDC+         W NVKVNFDNV  GYLA
Sbjct: 1305 VNLFAGKFYHCVNMTTG--NMFDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLA 1360

Query: 1360 LLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIID 1419
            LLQVATFKGWMDIMYAAVDSR+V +QP +E+N+YMYLYFVIFIIFG FFTLNLF+GVIID
Sbjct: 1361 LLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIID 1420

Query: 1420 NFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFD 1479
            NFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NKFQG VFD VTRQ FD
Sbjct: 1421 NFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFD 1480

Query: 1480 ITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGW 1539
            I+IM+LICLNM+TMMVETDDQ +  T +L +IN  F+ +FTGE V+K+ +LR YYFT GW
Sbjct: 1481 ISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGW 1540

Query: 1540 NVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFA 1599
            N+FDF+VV+LSI  +  + +++  + + SPTLFRVIRLARIGRILRLI+ AKGIRTLLFA
Sbjct: 1541 NIFDFVVVILSIVGMFLAEMIE--KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFA 1598

Query: 1600 LMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITT 1659
            LMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+ EAGIDDMFNF+TF NSM+CLFQITT
Sbjct: 1599 LMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITT 1658

Query: 1660 SAGWDGLLSPILNTGPPYCDPN-LPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYI 1718
            SAGWDGLL+PILN+ PP CDP+ +   +  +GDCG+P+VGI FF +YIIISFL++VNMYI
Sbjct: 1659 SAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYI 1718

Query: 1719 AVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIP 1778
            AVILENF+VATEES EPLSEDDF+MFYE WEKFDP+ATQFI FS LSDFA  L  PL I 
Sbjct: 1719 AVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIA 1778

Query: 1779 KPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSS 1838
            KPN+  LI MDLP+V GD+IHCLDILFAFTK VLGESGE+D+L+  ME++FMA+N SK S
Sbjct: 1779 KPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVS 1838

Query: 1839 YEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFT 1898
            YEPI TTL+ KQE++SA +IQ+ +R Y+L + +   ++     A +    LP +  +   
Sbjct: 1839 YEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIID 1898

Query: 1899 ANENCVLPDKSETASATSFPPSYESVTR 1926
                   P+K++ +S+T+ PPSY+SVT+
Sbjct: 1899 KLNGNSTPEKTDGSSSTTSPPSYDSVTK 1926


>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
            [Homo sapiens]
          Length = 2000

 Score = 2105 bits (5455), Expect = 0.0
 Identities = 1133/2029 (55%), Positives = 1406/2029 (69%), Gaps = 180/2029 (8%)

Query: 12   NFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGELP 71
            +FR FT ESL  IEK+ A ++  K  +E   +  D E KP+P  DL+A   LP  YG++P
Sbjct: 13   SFRLFTRESLAAIEKRAAEEKAKKPKKE---QDNDDENKPKPNSDLEAGKNLPFIYGDIP 69

Query: 72   AELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSW 131
             E++ EPLEDLDP+Y   +TF+V+NKG+ I RFSAT AL++ +P N +R+ AIK+ VHS 
Sbjct: 70   PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129

Query: 132  FSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLRDP 188
            FS+ I  TIL NCV MT ++ P+    +EY FT IYTFE+LIKILARGFCL +FT+LRDP
Sbjct: 130  FSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDP 189

Query: 189  WNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLAD 248
            WNWLDFSVI +AYV   +DL  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL+D
Sbjct: 190  WNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSD 249

Query: 249  VTILTIFCLSVFALVGLQLFKGNLKNKCVK----------------------NDMAVN-- 284
            V ILT+FCLSVFAL+GLQLF GNL+NKC++                      N   VN  
Sbjct: 250  VMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVT 309

Query: 285  -ETTNYSSHRKPDIYINKR-GTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSF 342
              T N+  +   D +     G  DPLLCGNGSD+G CP+GYIC+K   NP++ YTSFD+F
Sbjct: 310  MSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTF 369

Query: 343  AWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEE 402
            +WAFLSLFRLMTQD WE LYQ TLR +GK YMIFFVLVIFLGSFYLVNLILAVV MAYEE
Sbjct: 370  SWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEE 429

Query: 403  QNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNG--------------S 448
            QNQAT +E E KE +FQ+ LE L+K+QE   A+   + +    +G              S
Sbjct: 430  QNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEAS 489

Query: 449  PLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQ-------RRMSFLGLASGKR---- 497
             L+SK+A E R+R K R      E N     D + +       +R SFL    G R    
Sbjct: 490  KLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSD 549

Query: 498  ---------------------RASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESHR 534
                                 R S  S+F FR   +D+       DD    F  D ES R
Sbjct: 550  KKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFE-DSESRR 608

Query: 535  GSLLLGGGAGQ-------QGPLPRSPLPQ-PSNPD-----------SRHGEDEHQPPPTS 575
             SL +    G+       Q  +    +P  P+N             S  G       PT 
Sbjct: 609  DSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSALTSPTG 668

Query: 576  ELAP-GAVDVSAFDAGQKKTF-LSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPP 633
            +L P G    +     +  ++ +S E L++    QRA+S+ SI+T+ +EELEES QKCPP
Sbjct: 669  QLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPP 728

Query: 634  CLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTF 693
            C    +  +LIWDCC  W+K+K ++  +V DPF +L IT+CIV+NT+FMAMEH+ M+  F
Sbjct: 729  CWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQF 788

Query: 694  EAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLS 753
             ++L +GN+VFT  FTAEMV KIIA DPYYYFQ+ WNIFD IIV++SL+ELG++    LS
Sbjct: 789  SSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLS 848

Query: 754  VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENY 813
            VLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y
Sbjct: 849  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 908

Query: 814  RNNRKNISAPHED--WPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFL 871
               ++ +   ++D   PRWHM+DFFHSFLIVFR+LCGEWIE MW CMEV  +++CLI+F+
Sbjct: 909  ---KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFM 965

Query: 872  TVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSF 931
             VMV+GNLVVLNLF+ALLL+SFS+DNL A +DD E+NNLQ+A+ R+Q      K  +   
Sbjct: 966  LVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMREC 1025

Query: 932  FSRSCPFPQPKA---------EPELVVKLPLSSSKAENHI--AANTARGSSGGLQAPRGP 980
            F ++  F +PK          +  +     +  SK  N++     T  G   G    +  
Sbjct: 1026 FQKAF-FRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYV 1084

Query: 981  RDE--HSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVER 1038
             DE  +  FI NP++ V+VPIA GESD ++L                             
Sbjct: 1085 IDENDYMSFINNPSLTVTVPIAVGESDFENLNT--------------------------- 1117

Query: 1039 CGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEIL 1098
                                    E +  ES  +   E ++ TSSSEGSTVD + P E  
Sbjct: 1118 ------------------------EEFSSESELEESKEKLNATSSSEGSTVDVVLPREGE 1153

Query: 1099 RKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFI 1158
            +   E  +DL +P+ CFTEGCI+  P C++ T +    + W +RKTCY IVEH+WFE+FI
Sbjct: 1154 QAETEPEEDL-KPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFI 1212

Query: 1159 IFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAW 1218
            +FMILLSSG+LAFED Y++Q+ T+K +LEY D+VFT+IF+ EMLLKWVAYGF+ YFTNAW
Sbjct: 1213 VFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAW 1272

Query: 1219 CWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAI 1278
            CWLDFLIV++SL+SL A  L YSE+  IK+LRTLRALRPLRALSRFEGMRVVV+ALVGAI
Sbjct: 1273 CWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAI 1332

Query: 1279 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNST 1338
            PSIMNVLLVCLIFWLIFSIMGVNLFAGKF+ C+N T G  ++  +S VNN SDC+     
Sbjct: 1333 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTG--NMFDISDVNNLSDCQALGKQ 1390

Query: 1339 GSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYF 1398
                W NVKVNFDNV  GYLALLQVATFKGWMDIMYAAVDSR+V +QP +E+N+YMYLYF
Sbjct: 1391 AR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYF 1448

Query: 1399 VIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1458
            VIFIIFG FFTLNLF+GVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPI
Sbjct: 1449 VIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1508

Query: 1459 PRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAV 1518
            PRP NKFQG VFD VTRQ FDI+IM+LICLNM+TMMVETDDQ +  T +L +IN  F+ +
Sbjct: 1509 PRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVL 1568

Query: 1519 FTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLA 1578
            FTGE V+K+ +LR YYFT GWN+FDF+VV+LSI  +  + +++  + + SPTLFRVIRLA
Sbjct: 1569 FTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE--KYFVSPTLFRVIRLA 1626

Query: 1579 RIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGI 1638
            RIGRILRLI+ AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+ EAGI
Sbjct: 1627 RIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGI 1686

Query: 1639 DDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPN-LPNSNGTRGDCGSPAV 1697
            DDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP+ +   +  +GDCG+P+V
Sbjct: 1687 DDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSV 1746

Query: 1698 GIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQ 1757
            GI FF +YIIISFL++VNMYIAVILENF+VATEES EPLSEDDF+MFYE WEKFDP+ATQ
Sbjct: 1747 GIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQ 1806

Query: 1758 FITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGE 1817
            FI FS LSDFA  L  PL I KPN+  LI MDLP+V GD+IHCLDILFAFTK VLGESGE
Sbjct: 1807 FIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGE 1866

Query: 1818 LDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTP 1877
            +D+L+  ME++FMA+N SK SYEPI TTL+ KQE++SA +IQ+ +R Y+L + +   ++ 
Sbjct: 1867 MDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSN 1926

Query: 1878 CVPRAEEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPSYESVTR 1926
                A +    LP +  +          P+K++ +S+T+ PPSY+SVT+
Sbjct: 1927 YNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTK 1975


>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
            sapiens]
          Length = 1998

 Score = 2097 bits (5432), Expect = 0.0
 Identities = 1135/2040 (55%), Positives = 1408/2040 (69%), Gaps = 185/2040 (9%)

Query: 11   NNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEK-PRPQLDLKACNQLPKFYGE 69
            ++F  FT ESL  IE++IA +    KA+    ++KD +E  P+P  DL+A   LP  YG+
Sbjct: 12   DSFNFFTRESLAAIERRIAEE----KAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGD 67

Query: 70   LPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVH 129
            +P E++ EPLEDLDP+Y   +TF+VLNKG+ I RFSAT AL++ +PFN +R+ AIK+ VH
Sbjct: 68   IPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVH 127

Query: 130  SWFSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLR 186
            S FS+ I  TIL NCV MT ++ P+    +EY FT IYTFE+LIKI+ARGFCL +FT+LR
Sbjct: 128  SLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLR 187

Query: 187  DPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKL 246
            DPWNWLDF+VIT AYV   +DL  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL
Sbjct: 188  DPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKL 247

Query: 247  ADVTILTIFCLSVFALVGLQLFKGNLKNKCVK---------------------NDMAVNE 285
            +DV ILT+FCLSVFAL+GLQLF GNL+NKC++                     N   +NE
Sbjct: 248  SDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINE 307

Query: 286  TT---NYSSHRKPDIY-INKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDS 341
            T    ++ S+ +   Y     G  D LLCGN SD+G CP+GY+C+K   NP++ YTSFD+
Sbjct: 308  TVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDT 367

Query: 342  FAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYE 401
            F+WAFLSLFRLMTQD WE LYQ TLR +GK YMIFFVLVIFLGSFYL+NLILAVV MAYE
Sbjct: 368  FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYE 427

Query: 402  EQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHN-------------GS 448
            EQNQAT +E E KE +FQ+ +E L+K+QE        T S HS                S
Sbjct: 428  EQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEAS 487

Query: 449  PLTSKNASERRHRIKPRV----SEGSTEDN----KSPRSDPY------------------ 482
             L+SK+A ERR+R K R     S G  +D     KS   D                    
Sbjct: 488  KLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEK 547

Query: 483  -----NQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESHRG 535
                 +Q  +S  G     RR S  S+F FR   +D+       DD    F  D+ES R 
Sbjct: 548  RYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFE-DNESRRD 606

Query: 536  SLLLGGGAGQQGPLPRSPLPQPSNPD----------------------SRHGEDEHQPPP 573
            SL +    G++     S L Q S                         S  G       P
Sbjct: 607  SLFVPRRHGERR---NSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSP 663

Query: 574  TSELAP-GAVDVSAFDAGQKKTF-LSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKC 631
              +L P G    +     +  +F +S ++L++P + QRAMS+ SI+T+ +EELEES QKC
Sbjct: 664  VGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKC 723

Query: 632  PPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP 691
            PPC    S  +LIWDC P W+K+K ++  +V DPF +L IT+CIV+NT+FMAMEH+ M+ 
Sbjct: 724  PPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTD 783

Query: 692  TFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGS 751
             F  +L +GN+VFT  FTAEM  KIIA DPYYYFQ+ WNIFD  IVT+SL+ELG+A    
Sbjct: 784  HFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843

Query: 752  LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGE 811
            LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G+
Sbjct: 844  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 903

Query: 812  NYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFL 871
            +Y++    I++  +  PRWHM+DFFHSFLIVFR+LCGEWIE MW CMEV  +++CL +F+
Sbjct: 904  SYKDCVCKIASDCQ-LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFM 962

Query: 872  TVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSF 931
             VMV+GNLVVLNLF+ALLL+SFSADNL A +DD E+NNLQ+A+ R+       K+ +  F
Sbjct: 963  MVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEF 1022

Query: 932  FSRSCPFPQPKAEPELVVKLPLSSSK---AENHIAA------------NTARGSSGGLQA 976
              +S    + K   E+     L++ K     NH A              T  G   G   
Sbjct: 1023 IQQSF-IRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSSV 1081

Query: 977  PRGPRDE--HSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQ 1034
             +   DE  +  FI NP++ V+VPIA GESD ++L      + + F  E   +  +E+L 
Sbjct: 1082 EKYIIDESDYMSFINNPSLTVTVPIAVGESDFENL------NTEDFSSESDLEESKEKLN 1135

Query: 1035 QVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDP 1094
                                                        + +SSSEGSTVD   P
Sbjct: 1136 --------------------------------------------ESSSSSEGSTVDIGAP 1151

Query: 1095 EEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWF 1154
             E  + + E  + L EP+ CFTEGC++   CC+++  +      W +R+TC+RIVEH+WF
Sbjct: 1152 VE-EQPVVEPEETL-EPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWF 1209

Query: 1155 ESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYF 1214
            E+FI+FMILLSSG+LAFED Y+DQ+ T+K +LEY D+VFT+IF+ EMLLKWVAYG++ YF
Sbjct: 1210 ETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYF 1269

Query: 1215 TNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDAL 1274
            TNAWCWLDFLIV++SL+SLTA  L YSE+  IK+LRTLRALRPLRALSRFEGMRVVV+AL
Sbjct: 1270 TNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNAL 1329

Query: 1275 VGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDC-K 1333
            +GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF+ CIN T G+     +  VNN +DC K
Sbjct: 1330 LGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGD--RFDIEDVNNHTDCLK 1387

Query: 1334 IQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVY 1393
            +     +  W NVKVNFDNV  GYL+LLQVATFKGWMDIMYAAVDSR V +QPK+E+++Y
Sbjct: 1388 LIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLY 1447

Query: 1394 MYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1453
            MYLYFVIFIIFG FFTLNLF+GVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKK
Sbjct: 1448 MYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1507

Query: 1454 PQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQ 1513
            PQKPIPRP NKFQG VFD VTRQ FDI+IM+LICLNM+TMMVETDDQSE  T IL +IN 
Sbjct: 1508 PQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINL 1567

Query: 1514 FFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFR 1573
             F+ +FTGECV+K+ +LR YYFT GWN+FDF+VV+LSI  +  + +++  + + SPTLFR
Sbjct: 1568 VFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIE--KYFVSPTLFR 1625

Query: 1574 VIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVR 1633
            VIRLARIGRILRLI+ AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+
Sbjct: 1626 VIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 1685

Query: 1634 WEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPN-SNGTRGDC 1692
             E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDPN  N  +  +GDC
Sbjct: 1686 REVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDC 1745

Query: 1693 GSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFD 1752
            G+P+VGI FF +YIIISFL++VNMYIAVILENF+VATEES EPLSEDDF+MFYE WEKFD
Sbjct: 1746 GNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFD 1805

Query: 1753 PEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVL 1812
            P+ATQF+ F  LS FA  L  PL +P+PN+  LI MDLP+V GD+IHCLDILFAFTK VL
Sbjct: 1806 PDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVL 1865

Query: 1813 GESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSM- 1871
            GESGE+D+L+  MEE+FMA+N SK SY+PI TTL+ KQE++SA +IQ+AYR ++L R++ 
Sbjct: 1866 GESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVK 1925

Query: 1872 ALSNTPCVPRAEEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPSYESVTRGLSDR 1931
              S T    + +  A  L  E  +    NEN +      T S  + PPSY+ VT+ + ++
Sbjct: 1926 QASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEK 1985


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score = 2082 bits (5394), Expect = 0.0
 Identities = 1120/2033 (55%), Positives = 1413/2033 (69%), Gaps = 164/2033 (8%)

Query: 12   NFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGELP 71
            +F  FT +SL  IE++IA ++  +   EK   + D EE P+P  DL+A  QLP  YG++P
Sbjct: 11   SFVHFTKQSLALIEQRIAERKSKEPKEEK---KDDDEEAPKPSSDLEAGKQLPFIYGDIP 67

Query: 72   AELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSW 131
              ++ EPLEDLDP+Y+  +TF+VLNKG+TI RF+AT AL++ SPF+ +RR +IK+ VHS 
Sbjct: 68   PGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSL 127

Query: 132  FSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLRDP 188
            FS+ I  TIL NC+ MT  + P+    +EY FT IYTFE+L+KILARGFC+ EFT+LRDP
Sbjct: 128  FSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDP 187

Query: 189  WNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLAD 248
            WNWLDF VI  AY+   ++L  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL+D
Sbjct: 188  WNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSD 247

Query: 249  VTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETT--------NYSSHRKPDIYIN 300
            V ILT+FCLSVFAL+GLQLF GNLK+KC +N +  NET         +    RK   Y+ 
Sbjct: 248  VMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLE 307

Query: 301  KRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWER 360
              G+ D LLCG  +DSG CP+GY C+K   NPD+ YTSFD+F+WAFL+LFRLMTQD WE 
Sbjct: 308  --GSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWEN 365

Query: 361  LYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQE 420
            LYQQTLR +GK YMIFFV+VIFLGSFYL+NLILAVV MAYEEQNQA  +E + KE +FQ+
Sbjct: 366  LYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQ 425

Query: 421  ALEMLRKEQE---VLAALGIDTTSLH----------SHNGSPLTSKNASERRHRIKPR-- 465
             L+ L+KEQE    +AA   + TS+           S   S L+SK+A ERR+R K +  
Sbjct: 426  MLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQ 485

Query: 466  --------------VSEGSTEDN----------------KSPRSDPYNQRRMSFLGLASG 495
                          +S+  +ED+                   R    NQ  +S  G    
Sbjct: 486  KKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFS 545

Query: 496  KRRASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESHRGSLLLGGGAGQQ-----GP 548
             RR+S  S+F F+  GRDI       DD   +F GD+ES RGSL +     ++       
Sbjct: 546  ARRSSRTSLFSFKGRGRDIGSETEFADDEHSIF-GDNESRRGSLFVPHRPQERRSSNISQ 604

Query: 549  LPRSPLPQPSNPDSRHGEDEHQPP-----------PTSELAPGAVDVSAFDAGQKKTFL- 596
              RSP   P N       D +              P  +L P           +  ++L 
Sbjct: 605  ASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCSSYLL 664

Query: 597  SAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKT 656
            S + L++P   QRAMS  SI+T+ +EELEES QKCPP     + K+LIW+C P W+K K 
Sbjct: 665  SEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKK 724

Query: 657  ILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKI 716
             ++ +V DPF +L IT+CIV+NT+FMAMEHH M+  F+ +L IGN+VFT  F AEMV K+
Sbjct: 725  CIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKL 784

Query: 717  IAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTL 776
            IA DPY YFQ  WNIFD +IVT+SL+EL +A    LSVLRSFRLLRVFKLAKSWPTLN L
Sbjct: 785  IAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNML 844

Query: 777  IKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDW--PRWHMHD 834
            IKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y+   + +   ++D   PRWHM+D
Sbjct: 845  IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK---ECVCKINDDCTLPRWHMND 901

Query: 835  FFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFS 894
            FFHSFLIVFR+LCGEWIE MW CMEV  +++CLI+++ VMV+GNLVVLNLF+ALLL+SFS
Sbjct: 902  FFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFS 961

Query: 895  ADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLS 954
            +DNLTA E+D + NNLQ+A+ RI+   +  KQ L  F  ++    +PK   E+     L+
Sbjct: 962  SDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFS-KKPKISREIRQAEDLN 1020

Query: 955  SSKAENHIAANTARGSSGG---------LQAPRGPRDEH-------SDFIANPTVWVSVP 998
            + K EN+I+ +T    S G         +       D+H         FI NP++ V+VP
Sbjct: 1021 TKK-ENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVP 1079

Query: 999  IAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLA 1058
            IA GES           D ++   E +      +  +V                      
Sbjct: 1080 IAPGES-----------DLENMNAEELSSDSDSEYSKVR--------------------- 1107

Query: 1059 PSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEG 1118
                               ++ +SSSE STVD   P E      E  +  +EP+ CFT+G
Sbjct: 1108 -------------------LNRSSSSECSTVDNPLPGEGEEAEAEPMNS-DEPEACFTDG 1147

Query: 1119 CIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQ 1178
            C+R   CC+++       + W +RKTCY+IVEHSWFESFI+ MILLSSG+LAFED Y+++
Sbjct: 1148 CVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIER 1207

Query: 1179 KPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKIL 1238
            K T+K +LEY D++FT+IF+ EMLLKW+AYG+K YFTNAWCWLDFLIV++SL++L A  L
Sbjct: 1208 KKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTL 1267

Query: 1239 EYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIM 1298
             YS++ PIK+LRTLRALRPLRALSRFEGMRVVV+AL+GAIPSIMNVLLVCLIFWLIFSIM
Sbjct: 1268 GYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIM 1327

Query: 1299 GVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDC-KIQNSTGSFFWVNVKVNFDNVAMGY 1357
            GVNLFAGKF+ CIN TDG  S  P S V N+S+C  + N + +  W N+KVNFDNV +GY
Sbjct: 1328 GVNLFAGKFYECINTTDG--SRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGY 1385

Query: 1358 LALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVI 1417
            L+LLQVATFKGW  IMYAAVDS  V+ QPK+E ++YMY+YFV+FIIFG FFTLNLF+GVI
Sbjct: 1386 LSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVI 1445

Query: 1418 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQA 1477
            IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG +FD+VT QA
Sbjct: 1446 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQA 1505

Query: 1478 FDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTN 1537
            FDI+IMVLICLNM+TMMVE + QS+  T++L  IN  F+ +FTGECV+K+ +LR YYFT 
Sbjct: 1506 FDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTV 1565

Query: 1538 GWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLL 1597
            GWN+FDF+VV++SI  +  + ++++   + SPTLFRVIRLARIGRILRL++ AKGIRTLL
Sbjct: 1566 GWNIFDFVVVIISIVGMFLADLIETY--FVSPTLFRVIRLARIGRILRLVKGAKGIRTLL 1623

Query: 1598 FALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQI 1657
            FALMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+ E GI+DMFNF+TF NSM+CLFQI
Sbjct: 1624 FALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQI 1683

Query: 1658 TTSAGWDGLLSPILNTGPPYCDP-NLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNM 1716
            TTSAGWDGLL+PILN+ PP CDP  +   +   GDCG+P+VGI +F +YIIISFL++VNM
Sbjct: 1684 TTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNM 1743

Query: 1717 YIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLR 1776
            YIAVILENF+VATEESTEPLSEDDF+MFYE WEKFDP+ATQFI FS LSDFA  L  PL 
Sbjct: 1744 YIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLL 1803

Query: 1777 IPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSK 1836
            I KPN+  LI MDLP+V GD+IHCLDILFAFTK VLGESGE+DSL++ MEE+FM+ N SK
Sbjct: 1804 IAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSK 1863

Query: 1837 SSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVA 1896
             SYEPI TTL+ KQED+SATVIQ+AYR Y L +++   ++  +   + +   L  +    
Sbjct: 1864 VSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKDMAF 1923

Query: 1897 FTANENCVLPDKSETASATSFPPSYESVTRGLSDRVNM-RTSSSIQNEDEATS 1948
               NEN   P+K++  S+T+ PPSY+SVT+   ++    RT    + +D   S
Sbjct: 1924 DNVNENS-SPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKES 1975


>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
            sapiens]
          Length = 1980

 Score = 2059 bits (5335), Expect = 0.0
 Identities = 1134/2024 (56%), Positives = 1394/2024 (68%), Gaps = 191/2024 (9%)

Query: 11   NNFRRFTPESLVEIEKQIAAKQGTK--KAREKHREQKDQEEKPRPQLDLKACNQLPKFYG 68
            ++F+ FTPESL  IE++IA  +  K  KA   HRE  D++ KP+P  DL+A   LP  YG
Sbjct: 12   DSFKPFTPESLANIERRIAESKLKKPPKADGSHRED-DEDSKPKPNSDLEAGKSLPFIYG 70

Query: 69   ELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSV 128
            ++P  L+  PLED DP+Y T +TF+VLN+G+T+ RFSAT AL++ SPFNLIRR AIK+ +
Sbjct: 71   DIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILI 130

Query: 129  HSWFSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYL 185
            HS FS+ I  TIL NCV MT ++ P+    +EY FT IYTFE+L+KI+ARGFC++ FT+L
Sbjct: 131  HSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFL 190

Query: 186  RDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKK 245
            RDPWNWLDFSVI +AY+   ++L  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKK
Sbjct: 191  RDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKK 250

Query: 246  LADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNET--TNYSSHRKPDIYINKR- 302
            L+DV ILT+FCLSVFAL+GLQLF GNL+NKCV   +  NE+   N +     + YIN + 
Sbjct: 251  LSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKT 310

Query: 303  ------GTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQD 356
                  G  +PLLCGN SD+G CP+GY C+K   NP++ YTSFD+F+WAFL+LFRLMTQD
Sbjct: 311  NFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQD 370

Query: 357  SWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEK 416
             WE LYQ TLR +GK YMIFFVLVIF+GSFYLVNLILAVV MAYEEQNQAT +E E KE 
Sbjct: 371  YWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEA 430

Query: 417  KFQEALEMLRKEQEVLAALGIDTTSL-----------HSHNGSP--------LTSKNASE 457
            +F+  LE L+K+QE   A  + T++                GSP        L+SK+A E
Sbjct: 431  EFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKE 490

Query: 458  RRHRIKPR----VSEGSTE-----------------------DNKSPRS-DPYNQRRMSF 489
            RR+R K R    +SEG  +                       DN+  R     NQ  +S 
Sbjct: 491  RRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSI 550

Query: 490  LGLASGKRRASHGSVFHFRSPGR---DISLPEGVTDDGVFPGDHESHRGSLLL------- 539
             G     R  S  S+F FR PGR     S  E   D+     + E  R SL +       
Sbjct: 551  PGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARER 610

Query: 540  -----GGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGA-----------VD 583
                 G     QG       P       R+   +     +    PG+            +
Sbjct: 611  RSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLLPEATTE 670

Query: 584  VSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVL-EELEESEQKCPPCLTSLSQKY 642
            V     G     +S + L    R  R  S++S++T+ L EELEES++KCPPC    +  +
Sbjct: 671  VEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTF 730

Query: 643  LIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNI 702
            LIW+C P W+KLK I+  +V DPF +L IT+CIV+NT+FMAMEHH M+P FE +L +GN+
Sbjct: 731  LIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNL 790

Query: 703  VFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLR 762
            VFT  FTAEM  K+IA DPYYYFQ+ WNIFD  IV++SL+EL +A    LSVLRSFRLLR
Sbjct: 791  VFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLR 850

Query: 763  VFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISA 822
            VFKLAKSWPTLN LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y+     I+ 
Sbjct: 851  VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQ 910

Query: 823  PHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVL 882
              E  PRWHMHDFFHSFLIVFR+LCGEWIE MW CMEV  +++CLI+F+ VMV+GNLVVL
Sbjct: 911  DCE-LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVL 969

Query: 883  NLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPK 942
            NLF+ALLL+SFSADNL A +DDGE+NNLQ+++ RI+     TK  + +F      F Q +
Sbjct: 970  NLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFM--QAHFKQRE 1027

Query: 943  AEPELVVKLPLSSSKAE---NHIAANTAR---------GSSGGLQAPRGP---RDEHSDF 987
            A+ E+     L   KA    NH  A+  R         G++ G+ +        ++H  F
Sbjct: 1028 AD-EVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSF 1086

Query: 988  IANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRS 1047
            I NP + V VPIA GESD ++L     ED  S   E  P+G +++L              
Sbjct: 1087 INNPNLTVRVPIAVGESDFENLNT---EDVSS---ESDPEGSKDKL-------------- 1126

Query: 1048 PGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIP-ELAD 1106
                                           DDTSSSEGST+D + PE  + ++P E  +
Sbjct: 1127 -------------------------------DDTSSSEGSTID-IKPE--VEEVPVEQPE 1152

Query: 1107 DLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSS 1166
            +  +PD CFTEGC++   CC+++  +      W +RKTC+ IVEH+WFE+FIIFMILLSS
Sbjct: 1153 EYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSS 1212

Query: 1167 GSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIV 1226
            G+LAFED Y++Q+ T++ +LEY D+VFT+IF+ EMLLKW AYGF K+FTNAWCWLDFLIV
Sbjct: 1213 GALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIV 1272

Query: 1227 NISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLL 1286
             +SL+SL A  L YSE+  IK+LRTLRALRPLRALSRFEGMRVVV+ALVGAIPSIMNVLL
Sbjct: 1273 AVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLL 1332

Query: 1287 VCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCK--IQNSTGSFFWV 1344
            VCLIFWLIFSIMGVNLFAGK+  C N T        +  VNNK++C+  ++ +     W 
Sbjct: 1333 VCLIFWLIFSIMGVNLFAGKYHYCFNETSE--IRFEIEDVNNKTECEKLMEGNNTEIRWK 1390

Query: 1345 NVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIF 1404
            NVK+NFDNV  GYLALLQVATFKGWMDIMYAAVDSR+ + QPK+EDN+YMY+YFVIFIIF
Sbjct: 1391 NVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIF 1450

Query: 1405 GGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1464
            G FFTLNLF+GVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK
Sbjct: 1451 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1510

Query: 1465 FQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECV 1524
             QG VFD VT+QAFDI IM+LICLNM+TMMVETD QS++   IL  IN  FV  FT ECV
Sbjct: 1511 IQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECV 1570

Query: 1525 MKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRIL 1584
            +KMFALR YYFT GWN+FDF+VV+LSI  +  + I++  + + SPTLFRVIRLARIGRIL
Sbjct: 1571 LKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIE--KYFVSPTLFRVIRLARIGRIL 1628

Query: 1585 RLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNF 1644
            RLI+ AKGIRTLLFALMMSLPALFNIGLLLFLVMFI+SIFGMS+F +V+ EAGIDDMFNF
Sbjct: 1629 RLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNF 1688

Query: 1645 QTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC--DPNLPNSNGTRGDCGSPAVGIIFF 1702
            +TF NSM+CLFQITTSAGWDGLL PILN  PP C  D   P S G +GDCG+P+VGI FF
Sbjct: 1689 ETFGNSMICLFQITTSAGWDGLLLPILNR-PPDCSLDKEHPGS-GFKGDCGNPSVGIFFF 1746

Query: 1703 TTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFS 1762
             +YIIISFLI+VNMYIA+ILENF+VATEES +PLSEDDF+ FYE WEKFDP+ATQFI + 
Sbjct: 1747 VSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYC 1806

Query: 1763 ALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLK 1822
             L+DFAD L  PLR+PKPN   LI MDLP+V GD+IHCLDILFAFTK VLG+SGELD L+
Sbjct: 1807 KLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILR 1866

Query: 1823 ANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRA 1882
              MEE+F+A+N SK SYEPI TTLR KQE++SA V+Q+AYR ++  R      T      
Sbjct: 1867 QQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKT------ 1920

Query: 1883 EEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPSYESVTR 1926
               +  L + G             +K E+  +T+  PSY+SVT+
Sbjct: 1921 --TSNKLENGG----------THREKKESTPSTASLPSYDSVTK 1952


>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
          Length = 1836

 Score = 1557 bits (4032), Expect = 0.0
 Identities = 805/1276 (63%), Positives = 961/1276 (75%), Gaps = 79/1276 (6%)

Query: 617  ITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIV 676
            I+  +EELEE+ QKCPP     + K LIW+CC  W+K K I+  +V DPF +L IT+CIV
Sbjct: 530  ISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIV 589

Query: 677  VNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCII 736
            +NT+FMAMEH+ M+  F+ +L +GN+VFT  FTAEMV K+IA DPY YFQ+ WNIFD II
Sbjct: 590  LNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSII 649

Query: 737  VTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAI 796
            VT+SL+ELG+A    LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLT++LAI
Sbjct: 650  VTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 709

Query: 797  IVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWA 856
            IVF+FA+VG QL G++Y+     I+    + PRWHMHDFFHSFLIVFRILCGEWIE MW 
Sbjct: 710  IVFIFAVVGMQLFGKSYKECVCKIALDC-NLPRWHMHDFFHSFLIVFRILCGEWIETMWD 768

Query: 857  CMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALAR 916
            CMEV  +++CL +FL VMV+GNLVVLNLF+ALLL+SFSAD+L A ++DGE+NNLQ+A+ R
Sbjct: 769  CMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGR 828

Query: 917  IQVFGHRTKQALCSFFSRSCPFPQP------------------KAEPELVVKLPLSSS-K 957
            I++     K  L          P+                   +  PE   K P     K
Sbjct: 829  IKLGIGFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLK 888

Query: 958  AENHIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDA 1017
             +NHI  +   G + G   P     +H +FI NP + + VPIA  ESDL+          
Sbjct: 889  KDNHILNHM--GLADG--PPSSLELDHLNFINNPYLTIQVPIASEESDLE---------- 934

Query: 1018 QSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEG 1077
                                       P    T T SE          +D   P  P   
Sbjct: 935  --------------------------MPTEEETDTFSEP---------EDSKKPPQP--- 956

Query: 1078 VDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDV 1137
            + D +SS  ST D   PEE   +  E   + E+P++CFTE C++  PC  +D ++     
Sbjct: 957  LYDGNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKK 1016

Query: 1138 GWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIF 1197
             W +R+ C++IVEH+WFE+FI+FMILLSSG+LAFED Y++Q+  ++ +LEY D+VFT+IF
Sbjct: 1017 WWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIF 1076

Query: 1198 VFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRP 1257
            + EMLLKWVAYGFK YFTNAWCWLDFLIV++S+ISL A  L YSE+ PIK+LRTLRALRP
Sbjct: 1077 IMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRP 1136

Query: 1258 LRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGE 1317
            LRALSRFEGMRVVV+AL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF+ CIN T  E
Sbjct: 1137 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSE 1196

Query: 1318 FSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAV 1377
                 +S VNNKS+C+    TG   W+NVKVN+DNV +GYL+LLQVATFKGWMDIMYAAV
Sbjct: 1197 --RFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAV 1254

Query: 1378 DSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTE 1437
            DSRE   QP++E N+YMYLYFVIFIIFG FFTLNLF+GVIIDNFNQQKKKLGG+DIFMTE
Sbjct: 1255 DSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTE 1314

Query: 1438 EQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVET 1497
            EQKKYYNAMKKLGSKKPQKPIPRP NK QG V+D+VT+QAFDITIM+LICLNM+TMMVET
Sbjct: 1315 EQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVET 1374

Query: 1498 DDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFS 1557
            D+QS+ K  IL  IN  F+ +FTGECV+KM ALRQYYFT GWN+FDF+VV+LSI  L  S
Sbjct: 1375 DNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALS 1434

Query: 1558 AILKSLQSYF-SPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFL 1616
             +   +Q YF SPTLFRVIRLARIGR+LRLIR AKGIRTLLFALMMSLPALFNIGLLLFL
Sbjct: 1435 DL---IQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFL 1491

Query: 1617 VMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPP 1676
            VMFIYSIFGMS+F +V+ E+GIDDMFNF+TF NS++CLF+ITTSAGWDGLL+PILN+GPP
Sbjct: 1492 VMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPP 1551

Query: 1677 YCDPNLPN-SNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEP 1735
             CDPNL N     +GDCG+P++GI FF +YIIISFLI+VNMYIA+ILENFNVATEES+EP
Sbjct: 1552 DCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEP 1611

Query: 1736 LSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPG 1795
            L EDDF+MFYETWEKFDP+ATQFI +S LSDF DTL  PLRI KPN+  LI +DLP+VPG
Sbjct: 1612 LGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPG 1671

Query: 1796 DKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISA 1855
            DKIHCLDILFA TK VLG+SGE+D+LK  MEEKFMA N SK SYEPI TTL+ K E++ A
Sbjct: 1672 DKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCA 1731

Query: 1856 TVIQKAYRSYVLHRSM 1871
              IQ+AYR ++L RSM
Sbjct: 1732 IKIQRAYRRHLLQRSM 1747



 Score =  496 bits (1276), Expect = e-139
 Identities = 263/468 (56%), Positives = 328/468 (70%), Gaps = 52/468 (11%)

Query: 14  RRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGELPAE 73
           R FT ESL  IE++ A ++  +  R K  E ++ E KPR   DL+A   LP  YG+ P E
Sbjct: 18  RPFTRESLAAIEQR-AVEEEARLQRNKQMEIEEPERKPRS--DLEAGKNLPMIYGDPPPE 74

Query: 74  LIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSWFS 133
           +IG PLEDLDP+YS  +TF+VLNKG+ I RFSAT AL+L SPF+++RR AIKV +H+ FS
Sbjct: 75  VIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIHALFS 134

Query: 134 LFITVTILVNCVCMTRTDLP---EKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWN 190
           +FI +TIL NCV MT +D P   + +EY FT IYTFE+LIKILARGFC+++FT+LRDPWN
Sbjct: 135 MFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWN 194

Query: 191 WLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVT 250
           WLDFSVI +AY+   +DL  IS LRTFRVLRALKT++VIPGLK IVGALI SVKKL+DV 
Sbjct: 195 WLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVM 254

Query: 251 ILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETT----------------------- 287
           ILT+FCLSVFALVGLQLF GNL+ KCV+     N+T                        
Sbjct: 255 ILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYG 314

Query: 288 --------NYSSHRK--------PDIYINK-------RGTSDPLLCGNGSDSGHCPDGYI 324
                    ++SH           D YI+         G++D LLCGN SD+GHCP+GY 
Sbjct: 315 NDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYE 374

Query: 325 CLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLG 384
           C+KT  NP++ YTS+D+F+WAFL+LFRLMTQD WE L+Q TLR +GK YMIFFV++IFLG
Sbjct: 375 CIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLG 434

Query: 385 SFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVL 432
           SFYL+NLILAVV MAY EQN+AT  E + KE++FQ+ LE  +K QE L
Sbjct: 435 SFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL 482



 Score =  101 bits (251), Expect = 8e-21
 Identities = 82/337 (24%), Positives = 155/337 (45%), Gaps = 60/337 (17%)

Query: 119  IRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLP-----------EKIEYVFTVIYTFE 167
            +RR   K+  H+WF  FI   IL++   +   D+            E  + VFT I+  E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079

Query: 168  ALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG------ISGLRTFRVLR 221
             L+K +A GF +    Y  + W WLDF ++ ++ +    +  G      I  LRT R LR
Sbjct: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135

Query: 222  ALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDM 281
             L+ +S   G++V+V AL+ ++  + +V ++ +    +F+++G+ LF G       K   
Sbjct: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG-------KFYY 1188

Query: 282  AVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDS 341
             +N TT   S R     +N +   + L+      +G     ++ +K          ++D+
Sbjct: 1189 CINTTT---SERFDISEVNNKSECESLM-----HTGQV--RWLNVK---------VNYDN 1229

Query: 342  FAWAFLSLFRLMTQDSWERLYQQTLRTSGK---------IYM-IFFVLVIFLGSFYLVNL 391
                +LSL ++ T   W  +    + +  K         +YM ++FV+ I  GSF+ +NL
Sbjct: 1230 VGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNL 1289

Query: 392  ILAVVTMAYEEQNQATTDE---IEAKEKKFQEALEML 425
             + V+   + +Q +    +   +  ++KK+  A++ L
Sbjct: 1290 FIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKL 1326



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 53/186 (28%), Positives = 98/186 (52%), Gaps = 22/186 (11%)

Query: 1133 SPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRV 1192
            SP+ V   VR+   +++ H+ F  FI+  IL +   +   D      P     +EYT   
Sbjct: 115  SPFSV---VRRGAIKVLIHALFSMFIMITILTNCVFMTMSD-----PPPWSKNVEYT--- 163

Query: 1193 FTFIFVFEMLLKWVAYGFK----KYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKA 1248
            FT I+ FE L+K +A GF      +  + W WLDF ++      + A + E+ ++  I A
Sbjct: 164  FTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISA 217

Query: 1249 LRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 1307
            LRT R LR L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 218  LRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLR 277

Query: 1308 WRCINY 1313
             +C+ +
Sbjct: 278  QKCVRW 283



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 67/287 (23%), Positives = 127/287 (44%), Gaps = 63/287 (21%)

Query: 134 LFITVTILVNCVCMTRTDLPEKIEY---------VFTVIYTFEALIKILARGFCLNEFTY 184
           L IT+ I++N + M     P    +         VFT I+T E ++K++A    ++ + Y
Sbjct: 582 LGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA----MDPYEY 637

Query: 185 LRDPWNWLDFSVITLAYVGTAI-DLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSV 243
            +  WN  D  ++TL+ V   + +++G+S LR+FR+LR  K     P L +++  + +SV
Sbjct: 638 FQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSV 697

Query: 244 KKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRG 303
             L ++T++    + +FA+VG+QLF G    +CV           +  H           
Sbjct: 698 GALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECVCKIALDCNLPRWHMH----------- 745

Query: 304 TSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQ 363
                                        DF    F SF    L +FR++  +  E ++ 
Sbjct: 746 -----------------------------DF----FHSF----LIVFRILCGEWIETMWD 768

Query: 364 QTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDE 410
                   + +  F++V+ +G+  ++NL LA++  ++   + A +DE
Sbjct: 769 CMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDE 815



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 79/373 (21%), Positives = 150/373 (40%), Gaps = 70/373 (18%)

Query: 1074 PAEGVDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCP--------- 1124
            PA G D   S + S  +   P +       ++D +EE ++   +     CP         
Sbjct: 500  PAHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAMEELEEAHQK-----CPPWWYKCAHK 554

Query: 1125 -----CCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQK 1179
                 CC      +PW    + +   + IV   + +  I   I+L++  +A E Y + + 
Sbjct: 555  VLIWNCC------APW---LKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEH 605

Query: 1180 PTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILE 1239
                 +L   + VFT IF  EM+LK +A    +YF   W   D +IV +SL+ L      
Sbjct: 606  --FDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGL---- 659

Query: 1240 YSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMG 1299
             + V  +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G
Sbjct: 660  -ANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 718

Query: 1300 VNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLA 1359
            + LF   +  C+                    CKI        W     +  +    +L 
Sbjct: 719  MQLFGKSYKECV--------------------CKIALDCNLPRW-----HMHDFFHSFLI 753

Query: 1360 LLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIID 1419
            + ++   + W++ M+   D  EV  Q            F++ ++ G    LNLF+ +++ 
Sbjct: 754  VFRILCGE-WIETMW---DCMEVAGQ------AMCLTVFLMVMVIGNLVVLNLFLALLLS 803

Query: 1420 NFNQQKKKLGGQD 1432
            +F+        +D
Sbjct: 804  SFSADSLAASDED 816



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 12/172 (6%)

Query: 671 ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA----FDPYYYFQ 726
           I + I+ N +FM M      P +   ++     FT  +T E + KI+A     D + + +
Sbjct: 137 IMITILTNCVFMTMSD---PPPWSKNVEY---TFTGIYTFESLIKILARGFCVDDFTFLR 190

Query: 727 KKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGA 786
             WN  D  ++ ++ L   V   G++S LR+FR+LR  K     P L T++  +  SV  
Sbjct: 191 DPWNWLDFSVIMMAYLTEFV-DLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKK 249

Query: 787 LGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDW-PRWHMHDFFH 837
           L ++ I+    + VFALVG QL   N R        P  D    W+ +D ++
Sbjct: 250 LSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWY 301



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 46/195 (23%), Positives = 89/195 (45%), Gaps = 29/195 (14%)

Query: 115  PFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMT---------RTDLPEKIEYVFTVIYT 165
            P N I+     +     F + I + I +N V M          + D+   I  +F +I+T
Sbjct: 1338 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFT 1397

Query: 166  FEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAI-DL--------RGISGLRT 216
             E ++K+LA    L ++ Y    WN  DF V+ L+ VG A+ DL             +R 
Sbjct: 1398 GECVLKMLA----LRQY-YFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRL 1452

Query: 217  FRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKC 276
             R+ R L+ +    G++ ++ AL+ S+  L ++ +L    + ++++ G+  F        
Sbjct: 1453 ARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNF------AY 1506

Query: 277  VKNDMAVNETTNYSS 291
            VK +  +++  N+ +
Sbjct: 1507 VKKESGIDDMFNFET 1521



 Score = 37.0 bits (84), Expect = 0.19
 Identities = 20/85 (23%), Positives = 44/85 (51%), Gaps = 1/85 (1%)

Query: 835 FFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFS 894
           F  +FL +FR++  ++ EN++           +I F+ ++ LG+  ++NL +A++  +++
Sbjct: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451

Query: 895 ADN-LTAPEDDGEVNNLQVALARIQ 918
             N  T  ED  +    Q  L + +
Sbjct: 452 EQNEATLAEDKEKEEEFQQMLEKFK 476



 Score = 35.4 bits (80), Expect = 0.55
 Identities = 22/100 (22%), Positives = 45/100 (45%), Gaps = 10/100 (10%)

Query: 1349 NFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFF 1408
            ++D  +  +LAL ++ T   W ++    + +             YM ++FV+ I  G F+
Sbjct: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAA---------GKTYM-IFFVVIIFLGSFY 437

Query: 1409 TLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1448
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477


>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
            sapiens]
          Length = 1791

 Score = 1332 bits (3447), Expect = 0.0
 Identities = 711/1289 (55%), Positives = 904/1289 (70%), Gaps = 61/1289 (4%)

Query: 596  LSAEYLDE---PFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWV 652
            LS ++ DE   P + QRA+S VSI+T  ++E E+S++ C PC  +L+ KYL+W+CCP W+
Sbjct: 505  LSLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWL 564

Query: 653  KLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEM 712
             +K +L  ++TDPF EL IT+CI++NT+F+AMEHH M  +FE ML IGN+VFT  F AEM
Sbjct: 565  CVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEM 624

Query: 713  VFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELG--VAKKGSLSVLRSFRLLRVFKLAKSW 770
              KIIA DPY+YF++ WNIFD I+  +S  ++   V +K S   LRSFR+LRVFKLAKSW
Sbjct: 625  CLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSW 684

Query: 771  PTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRK----NISAPHED 826
            PTLNTLIKIIGNSVGALG+LT++L I++F+F++VG QL G ++ + +     N + P   
Sbjct: 685  PTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVS 744

Query: 827  WPR-WHMHDFFHSFLIVFRILCGEWIENMWACMEVGQ--KSICLILFLTVMVLGNLVVLN 883
              R WHM DF+HSFL+VFRILCGEWIENMW CM+      S+C+I+F+ + V+G LVVLN
Sbjct: 745  CLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLN 804

Query: 884  LFIALLLNSFSADNLTAP-EDDGEVNNLQVALARIQ---VFGHRTKQALCSFFSRSCPFP 939
            LFIALLLNSFS +      E +     +Q+AL R +    F   T +  C  + R    P
Sbjct: 805  LFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQNLP 864

Query: 940  QPKAEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPI 999
            Q K     V     + SK    +     RGS    +         +  + +   W++ P+
Sbjct: 865  QQKE----VAGGCAAQSKDIIPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLA-PL 919

Query: 1000 AEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAP 1059
            AE E   DD+E  G ++AQ   Q   P+ Q  +L Q  +       +S      SED   
Sbjct: 920  AEEE---DDVEFSGEDNAQRITQPE-PEQQAYELHQENKKPTSQRVQSVEIDMFSED--- 972

Query: 1060 SLGETWKDESVPQVPAEGVDDTSS-SEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEG 1118
                  +     Q P +  D TS  SE ST+D  D       +PE+    ++P+ C  +G
Sbjct: 973  ------EPHLTIQDPRKKSDVTSILSECSTIDLQDG---FGWLPEMVPK-KQPERCLPKG 1022

Query: 1119 CIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQ 1178
                 PCC +D  K PW + W +RKTCY+IV+HSWFESFIIF+ILLSSG+L FED +L+ 
Sbjct: 1023 FGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLEN 1082

Query: 1179 KPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKIL 1238
            +P ++ LL  TD +FT IF+ EM+LKWVA+GF KYFT+AWC LDF+IV +S+ +L     
Sbjct: 1083 QPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI---- 1138

Query: 1239 EYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIM 1298
                +  +K+ RTLRALRPLRALS+FEGM+VVV+AL+GAIP+I+NVLLVCLIFWL+F I+
Sbjct: 1139 ---NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCIL 1195

Query: 1299 GVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYL 1358
            GV  F+GKF +CIN TD   S++  +I+ NKS C+    +G+F W+N KVNFDNV   YL
Sbjct: 1196 GVYFFSGKFGKCINGTD---SVINYTIITNKSQCE----SGNFSWINQKVNFDNVGNAYL 1248

Query: 1359 ALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVII 1418
            ALLQVATFKGWMDI+YAAVDS E   QP++E N   Y+YFV+FIIFG FFTLNLF+GVII
Sbjct: 1249 ALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVII 1308

Query: 1419 DNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAF 1478
            DNFNQQ+KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK QG VFDIVT Q F
Sbjct: 1309 DNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIF 1368

Query: 1479 DITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNG 1538
            DI I+ LI LNMI+MM E+ +Q +    IL  +N  FV +FT EC++K+FALRQYYFTNG
Sbjct: 1369 DIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNG 1428

Query: 1539 WNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLF 1598
            WN+FD +VV+LSI S + S +       F PTLFR++RLARIGRILRL+RAA+GIRTLLF
Sbjct: 1429 WNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLF 1488

Query: 1599 ALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQIT 1658
            ALMMSLP+LFNIGLLLFL+MFIY+I GM+ F  V  E+GIDD+FNF+TFA+SMLCLFQI+
Sbjct: 1489 ALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQIS 1548

Query: 1659 TSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYI 1718
            TSAGWD LLSP+L         +  + N +  +C  P +   +F +YIIISFLI+VNMYI
Sbjct: 1549 TSAGWDSLLSPMLR--------SKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYI 1600

Query: 1719 AVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIP 1778
            AVILENFN ATEES +PL EDDFD+FYE WEKFDPEATQFI +SALSDFAD L  PLR+ 
Sbjct: 1601 AVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVA 1660

Query: 1779 KPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSS 1838
            KPN+   + MDLP+V  D++HC+DILFAFT  VLG S  LDS+KA MEEKFM  N  K  
Sbjct: 1661 KPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKL 1720

Query: 1839 YEPIATTLRWKQEDISATVIQKAYRSYVL 1867
            YEPI TT + K+E+  A +IQKA+R Y++
Sbjct: 1721 YEPIVTTTKRKEEERGAAIIQKAFRKYMM 1749



 Score =  471 bits (1213), Expect = e-132
 Identities = 265/519 (51%), Positives = 342/519 (65%), Gaps = 20/519 (3%)

Query: 3   FPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQ 62
           +P+   +  NFR FT +SL  IEK+IA +    K ++K ++Q  +  +PRPQLDLKA  +
Sbjct: 6   YPVIFPDERNFRPFTSDSLAAIEKRIAIQ----KEKKKSKDQTGEVPQPRPQLDLKASRK 61

Query: 63  LPKFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRT 122
           LPK YG++P ELIG+PLEDLDPFY  H+TFMVLN+ RTI RFSA  AL++F PFN IR  
Sbjct: 62  LPKLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSL 121

Query: 123 AIKVSVHSWFSLFITVTILVNCVCM-------TRTDLPEKIEYVFTVIYTFEALIKILAR 175
           AI+VSVHS FS+FI  T+++NCV M       + ++  +  E VFT IY FEALIKILAR
Sbjct: 122 AIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILAR 181

Query: 176 GFCLNEFTYLRDPWNWLDFSVITLAYVG--TAIDLRGISGLRTFRVLRALKTVSVIPGLK 233
           GF L+EF++LRDPWNWLD  VI +A V     I ++ +  LRTFRV RALK +SV+  LK
Sbjct: 182 GFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK-LLPLRTFRVFRALKAISVVSRLK 240

Query: 234 VIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHR 293
           VIVGAL+ SVKKL +V ILT FCLS+FALVG QLF G+L  KC+  D       N S+  
Sbjct: 241 VIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK-----NISNPE 295

Query: 294 KPDIYINKRGTSDPL-LCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRL 352
             D    K+  S    +CG    +  C   Y C  T  NPD+NYT+FD+F W+FL++FRL
Sbjct: 296 AYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRL 355

Query: 353 MTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIE 412
           MTQDSWE+LYQQTLRT+G   + FF++VIFLGSFYL+NL LAVVTMAYEEQN+    EIE
Sbjct: 356 MTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIE 415

Query: 413 AKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTE 472
           AKEK FQEA ++L++E+E L A+GID +SL S   S  T K      ++ +       + 
Sbjct: 416 AKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESG 475

Query: 473 DNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPG 511
            ++ P SD     +     L   KR + + S+ HF   G
Sbjct: 476 KDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHG 514



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 89/332 (26%), Positives = 150/332 (45%), Gaps = 62/332 (18%)

Query: 119  IRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDL----PEKIE-------YVFTVIYTFE 167
            +R+T  ++  HSWF  FI   IL++   +   D+      KI+        +FT I+  E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104

Query: 168  ALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVS 227
             ++K +A GF      Y    W  LDF +I +  V T I+L  +   RT R LR L+ +S
Sbjct: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159

Query: 228  VIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKN-DMAVNET 286
               G+KV+V ALI ++  + +V ++ +    VF ++G+  F G    KC+   D  +N T
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCINGTDSVINYT 1218

Query: 287  TNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAF 346
                      I  NK        C +G+ S      +I  K +         FD+   A+
Sbjct: 1219 ----------IITNKSQ------CESGNFS------WINQKVN---------FDNVGNAY 1247

Query: 347  LSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVV 396
            L+L ++ T   W  +           QQ    S  +  I+FV+ I  GSF+ +NL + V+
Sbjct: 1248 LALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVI 1307

Query: 397  TMAYEEQNQATTDE---IEAKEKKFQEALEML 425
               + +Q +    +   +  ++KK+  A++ L
Sbjct: 1308 IDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKL 1339



 Score = 99.0 bits (245), Expect = 4e-20
 Identities = 80/345 (23%), Positives = 154/345 (44%), Gaps = 62/345 (17%)

Query: 1141 VRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFE 1200
            +R    R+  HS F  FII  ++++   +A        K +     +  + VFT I++FE
Sbjct: 118  IRSLAIRVSVHSLFSMFIIGTVIINCVFMATGP----AKNSNSNNTDIAECVFTGIYIFE 173

Query: 1201 MLLKWVAYGFK----KYFTNAWCWLDFLIVNISLIS----LTAKILEYSEVAPIKALRTL 1252
             L+K +A GF      +  + W WLD +++ I+++S    +T K+L          LRT 
Sbjct: 174  ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP---------LRTF 224

Query: 1253 RALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-WRCI 1311
            R  R L+A+S    ++V+V AL+ ++  ++NV+++      IF+++G  LF G    +CI
Sbjct: 225  RVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCI 284

Query: 1312 N-------------------YTDGEFSLVPLSIVNN----KSDCKIQNSTGSFFWVNVKV 1348
            +                       EF +  + + N+    + +CK       + +     
Sbjct: 285  SRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNY----T 340

Query: 1349 NFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFF 1408
            NFDN    +LA+ ++ T   W           ++  Q      +Y   +F++ I  G F+
Sbjct: 341  NFDNFGWSFLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSFY 390

Query: 1409 TLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1453
             +NL + V+   + +Q K +  +   +  ++K +  A + L  +K
Sbjct: 391  LINLTLAVVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 157/804 (19%), Positives = 296/804 (36%), Gaps = 175/804 (21%)

Query: 675  IVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA----FDPYYYFQKKWN 730
            +++N +FMA      S +      I   VFT  +  E + KI+A     D + + +  WN
Sbjct: 139  VIINCVFMATGPAKNSNSNNT--DIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196

Query: 731  IFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 790
              D I++ ++++         L  LR+FR+ R  K       L  ++  +  SV  L N+
Sbjct: 197  WLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNV 256

Query: 791  TIILAIIVFVFALVGKQLLGENYR-----NNRKNISAPH---------EDWPRWHM---- 832
             I+    + +FALVG+QL   +        + KNIS P          E+ P + M    
Sbjct: 257  IILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIW 316

Query: 833  --------------------------HDFFHSFLIVFRILCGEWIENMWACMEVGQKSIC 866
                                       +F  SFL +FR++  +  E ++           
Sbjct: 317  MGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYS 376

Query: 867  LILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQ 926
            +  F+ V+ LG+  ++NL +A++  ++   N           N+   +   +      +Q
Sbjct: 377  VFFFIVVIFLGSFYLINLTLAVVTMAYEEQN----------KNVAAEIEAKEKMFQEAQQ 426

Query: 927  ALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPR---GPRDE 983
             L             K E E +V + +  S         T+  +S      R   G +  
Sbjct: 427  LL-------------KEEKEALVAMGIDRSSL-------TSLETSYFTPKKRKLFGNKKR 466

Query: 984  HSDFIANPTVWVSVPIAEGESDLDDLE-DDGGEDAQSFQQEVIPKGQQEQLQQVERCGDH 1042
             S F+              ES  D     D  ED Q   Q +    +  Q   ++   +H
Sbjct: 467  KSFFLR-------------ESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEH 513

Query: 1043 LTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIP 1102
              P       S+  +   L  T K++   Q P     +  +S+    +C      ++K+ 
Sbjct: 514  GDPLQRQRALSAVSI---LTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKV- 569

Query: 1103 ELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMI 1162
             L   + +P   FTE  I  C                 +  T +  +EH   E+   F  
Sbjct: 570  -LRTVMTDP---FTELAITIC----------------IIINTVFLAMEHHKMEA--SFEK 607

Query: 1163 LLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLD 1222
            +L+ G+L F   ++ +                      M LK +A     YF   W   D
Sbjct: 608  MLNIGNLVFTSIFIAE----------------------MCLKIIALDPYHYFRRGWNIFD 645

Query: 1223 FLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIM 1282
             ++  +S   +   +L+      +++ R LR  +  ++      +  ++   VGA+ S +
Sbjct: 646  SIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-L 704

Query: 1283 NVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFF 1342
             V+LV +IF  IFS++G+ LF   F                   N++   K+ N TG   
Sbjct: 705  TVVLVIVIF--IFSVVGMQLFGRSF-------------------NSQKSPKLCNPTGPTV 743

Query: 1343 WVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFI 1402
                  +  +    +L + ++   + W++ M+         MQ     +    + F++  
Sbjct: 744  SCLRHWHMGDFWHSFLVVFRILCGE-WIENMWEC-------MQEANASSSLCVIVFILIT 795

Query: 1403 IFGGFFTLNLFVGVIIDNFNQQKK 1426
            + G    LNLF+ +++++F+ +++
Sbjct: 796  VIGKLVVLNLFIALLLNSFSNEER 819



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 71/323 (21%), Positives = 135/323 (41%), Gaps = 61/323 (18%)

Query: 119 IRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEY---------VFTVIYTFEAL 169
           +++    V    +  L IT+ I++N V +       +  +         VFT I+  E  
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625

Query: 170 IKILARGFCLNEFTYLRDPWNWLDFSVITLAY---VGTAIDLRGISGLRTFRVLRALKTV 226
           +KI+A    L+ + Y R  WN  D  V  L++   +   +  R    LR+FRVLR  K  
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681

Query: 227 SVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNET 286
              P L  ++  + +SV  L  +T++ +  + +F++VG+QLF  +  ++           
Sbjct: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQ----------- 730

Query: 287 TNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAF 346
                               P LC     +  C                +     F  +F
Sbjct: 731 ------------------KSPKLCNPTGPTVSC--------------LRHWHMGDFWHSF 758

Query: 347 LSLFRLMTQDSWERLYQ--QTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQN 404
           L +FR++  +  E +++  Q    S  + +I F+L+  +G   ++NL +A++  ++  + 
Sbjct: 759 LVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEE 818

Query: 405 QATTDEIEAKEKKFQEALEMLRK 427
           +    E EA++ K Q AL+  R+
Sbjct: 819 RNGNLEGEARKTKVQLALDRFRR 841



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 53/238 (22%), Positives = 99/238 (41%), Gaps = 43/238 (18%)

Query: 115  PFNLIRRTAIKVSVHSWFSLFITVTILVNCVCM---------TRTDLPEKIEYVFTVIYT 165
            P N  +     +     F + I   I++N + M             + + + +VF VI+T
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410

Query: 166  FEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG-----------ISGL 214
             E LIKI    F L ++ Y  + WN  D  V+ L+ V T I                  +
Sbjct: 1411 LECLIKI----FALRQY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465

Query: 215  RTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKN 274
            R  R+ R L+ V    G++ ++ AL+ S+  L ++ +L    + ++A++G+  F      
Sbjct: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSK---- 1521

Query: 275  KCVKNDMAVNETTNYSSHRKPDIYINKRGTS---DPLL---------CGNGSDSGHCP 320
              V  +  +++  N+ +     + + +  TS   D LL         C + S++ H P
Sbjct: 1522 --VNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLP 1577



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 38/174 (21%), Positives = 73/174 (41%), Gaps = 17/174 (9%)

Query: 1461 PLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFT 1520
            P N  +     +     F + I+  + +N + M       S      + +    F  ++ 
Sbjct: 114  PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171

Query: 1521 GECVMKM----FALRQYYFTNG-WNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVI 1575
             E ++K+    F L ++ F    WN  D IV+ ++I S I    +K L           +
Sbjct: 172  FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP----------L 221

Query: 1576 RLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSF 1629
            R  R+ R L+ I     ++ ++ AL+ S+  L N+ +L F  + I+++ G   F
Sbjct: 222  RTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275



 Score = 32.3 bits (72), Expect = 4.7
 Identities = 20/86 (23%), Positives = 37/86 (43%), Gaps = 12/86 (13%)

Query: 338  SFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK------------IYMIFFVLVIFLGS 385
            +F +FA + L LF++ T   W+ L    LR+               I   +FV  I +  
Sbjct: 1533 NFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISF 1592

Query: 386  FYLVNLILAVVTMAYEEQNQATTDEI 411
              +VN+ +AV+   +    + + D +
Sbjct: 1593 LIVVNMYIAVILENFNTATEESEDPL 1618


>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
            sapiens]
          Length = 1682

 Score = 1040 bits (2689), Expect = 0.0
 Identities = 566/1255 (45%), Positives = 793/1255 (63%), Gaps = 78/1255 (6%)

Query: 622  EELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIF 681
            EELE+S++ CP      ++ +LIW+C P W+KLK  +  ++  PF +L + +CI++N  F
Sbjct: 462  EELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCF 521

Query: 682  MAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSL 741
            + +EH+ MS     +L IGN+VF   FTAEM+FKIIA  PY YFQ  WNIFD +IV   L
Sbjct: 522  LTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGL 581

Query: 742  LELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVF 801
            +EL +A    +++LR FR+LR+FKL K WPT   L+  + NS  AL +L ++L   +F  
Sbjct: 582  IELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFS 641

Query: 802  ALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVG 861
            A  G +L G+NY     +I    +  PRWHMHDFFHSFL VFRILCGEW+E +W CMEV 
Sbjct: 642  AAFGMKLFGKNYEEFVCHIDKDCQ-LPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVA 700

Query: 862  QKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQV-F 920
             +S C+  +L V+++GNL+VL LF+AL+ +  S  ++TA E++ E  NLQ+A+ARI+   
Sbjct: 701  GQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGI 759

Query: 921  GHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSS---SKAENHIAANTARGSSGGLQAP 977
             +   + LC   +++ P        E+ VK  +S    S+  N       +  S G +  
Sbjct: 760  NYVLLKILCK--TQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEK- 816

Query: 978  RGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVE 1037
                +E    I +P+V  +VPIA GESD+++L      D +  Q +    G +E+++Q  
Sbjct: 817  NATENESQSLIPSPSVSETVPIASGESDIENL------DNKEIQSKSGDGGSKEKIKQ-- 868

Query: 1038 RCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVD-CLDPEE 1096
                                                       +SSSE STVD  +  EE
Sbjct: 869  -------------------------------------------SSSSECSTVDIAISEEE 885

Query: 1097 ILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFES 1156
             +    E +  L+        GC R     ++        +   +RKTC +IVE++WF+ 
Sbjct: 886  EMFYGGERSKHLKN-------GCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKC 938

Query: 1157 FIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTN 1216
            FI  + LLS+G+LAFED Y+DQ+ T+K LLEY D +FT+IF+ EMLLKW+AYGFK YF+N
Sbjct: 939  FIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSN 998

Query: 1217 AWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVG 1276
             W  LDF++V +  +SL  K  E      +K L +++ LRPLR LS+FE M+VVV AL+ 
Sbjct: 999  GWYRLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVVVRALIK 1053

Query: 1277 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQN 1336
                 +NV LVCL+ WLIFSIMGV+LFAG+F+ CI+ T GE    P S V NKS C+   
Sbjct: 1054 TTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGE--RFPSSEVMNKSRCESLL 1111

Query: 1337 STGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYL 1396
               S  W N K+NFDNV  G+L+LLQVATF GW+ IM +A+DS  VN+QP +E N+YMY 
Sbjct: 1112 FNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYC 1171

Query: 1397 YFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1456
            YF+ FIIFG F  L++ + VIIDNFN+ K KLGG +IF+T +Q+K Y  +KKL  +  Q+
Sbjct: 1172 YFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQR 1231

Query: 1457 PIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFV 1516
            P+PRPLNK QGF+FD+VT QAF++ +MVLIC   I MM++TD QS + +  L  IN  FV
Sbjct: 1232 PVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFV 1291

Query: 1517 AVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIR 1576
             ++T EC++K+ A R +YFT  WN+FDF+VV+ SI  L     + S      P+L ++I 
Sbjct: 1292 MLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSY--LVPPSLVQLIL 1349

Query: 1577 LARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEA 1636
            L+RI  +LRL +  K    L+  LM+SLPAL NI LL+FLVMFIY++FGM +F +V+ EA
Sbjct: 1350 LSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEA 1409

Query: 1637 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPN-SNGTRGDCGSP 1695
            GI+D+ NF+TF NSMLCLFQ+   AGWDG+L  I N+    CDP+  N     RGDCG+P
Sbjct: 1410 GINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNP 1469

Query: 1696 AVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEA 1755
            +VGI +F +YI+IS+LI+VNMYI V++E  N+A+++  + LSEDDF  F++ W++FDP+ 
Sbjct: 1470 SVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDR 1529

Query: 1756 TQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGES 1815
            TQ+I  S LSDFA  L  PL + KPN+  LI +DLP+  GD+IHCLDIL AFTK V+G+ 
Sbjct: 1530 TQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQD 1589

Query: 1816 GELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRS 1870
              ++ + + +E  F+  N  K + EPI TTL+ KQE +SAT+IQ+AY++Y L R+
Sbjct: 1590 VRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRN 1644



 Score =  351 bits (900), Expect = 5e-96
 Identities = 201/459 (43%), Positives = 274/459 (59%), Gaps = 25/459 (5%)

Query: 5   IGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEE-KPRPQLDLKACNQL 63
           + S E      FT ES   I++ IA         + H E  ++E+ KP P  DL+   +L
Sbjct: 2   LASPEPKGLVPFTKESFELIKQHIA---------KTHNEDHEEEDLKPTP--DLEVGKKL 50

Query: 64  PKFYGELPAELIGEPLEDLDPFYSTHR-TFMVLNKGRTISRFSATRALWLFSPFNLIRRT 122
           P  YG L   ++ EPLED+DP+Y   + TF+VLNK RTI RF+A   L   SPFN IRRT
Sbjct: 51  PFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRT 110

Query: 123 AIKVSVHSWFSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCL 179
            IKV VH +F LFI +++L++CV M+ T+LP+    +E     IYTFE L+K+ ARG   
Sbjct: 111 TIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWA 170

Query: 180 NEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGAL 239
             F++L DPWNWLDFSV     +     L  I  L+T R LR LK + +  GLK +VG L
Sbjct: 171 GSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVL 230

Query: 240 IHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVK------NDMAVNETTNYSSHR 293
           IH +K+L  V ILT+F LS+F+L+G+ LF GNLK+KC +      N+   N T N    R
Sbjct: 231 IHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIR 290

Query: 294 KPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLM 353
           + + +    G    LLCGN +D+G CP+GY+C+K   NPD  +T+FDSF WA  +LFRLM
Sbjct: 291 ETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLM 350

Query: 354 TQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEA 413
            QD  E LY Q L  SGK+YMIFFV+V FL SFY+ +L L ++ MAYEE+ Q   +  + 
Sbjct: 351 AQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKK 410

Query: 414 KEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTS 452
            E KFQ+  + L++  E   A    T  +     SP+++
Sbjct: 411 IEPKFQQTGKELQEGNETDEA---KTIQIEMKKRSPIST 446



 Score =  125 bits (315), Expect = 3e-28
 Identities = 148/703 (21%), Positives = 290/703 (41%), Gaps = 157/703 (22%)

Query: 1131 TKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTD 1190
            T SP++    +R+T  +++ H +F+ FI+  +L+    ++     L   P  + +LE T 
Sbjct: 100  TLSPFNC---IRRTTIKVLVHPFFQLFILISVLIDCVFMS-----LTNLPKWRPVLENTL 151

Query: 1191 R-VFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKAL 1249
              ++TF  + ++  + V  G   +  + W WLDF +    +I      + YS +  I  L
Sbjct: 152  LGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTL 205

Query: 1250 RTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-W 1308
            +T R LR L+ +   +G++ +V  L+  +  ++ V+++ L F  IFS++G+ LF G    
Sbjct: 206  QTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKH 265

Query: 1309 RCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVK--------------------- 1347
            +C  +     +    ++ N   +      T +F+++  +                     
Sbjct: 266  KCFRWPQENEN---ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVC 322

Query: 1348 -----------VNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYL 1396
                        NFD+      AL ++   + + +++Y  +              VYM  
Sbjct: 323  VKAGINPDQGFTNFDSFGWALFALFRLMA-QDYPEVLYHQILYA--------SGKVYMIF 373

Query: 1397 YFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGG----------------QDIFMTEEQK 1440
            + V+  +F  F+  +LF+G++   + ++K+++G                 Q+   T+E K
Sbjct: 374  FVVVSFLF-SFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAK 432

Query: 1441 KYYNAMKKLGS---------------------KKPQKPIPRPLNKF-------------- 1465
                 MKK                        +K +K  P    KF              
Sbjct: 433  TIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWL 492

Query: 1466 --QGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGEC 1523
              + FV  I+     D+ +++ I LN+  + +E    S++   +L   N  F+ +FT E 
Sbjct: 493  KLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEM 552

Query: 1524 VMKMFALRQY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGR 1582
            + K+ A+  Y YF  GWN+FD ++V   +  L  + +              ++RL R+ R
Sbjct: 553  IFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAG----------MALLRLFRMLR 602

Query: 1583 ILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSF--PHVRWEAGID- 1639
            I +L +     + L+++L  S  AL ++ LLLF  +F  + FGM  F   +  +   ID 
Sbjct: 603  IFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDK 662

Query: 1640 ----DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSP 1695
                  ++   F +S L +F+I      + L   +   G  +C P               
Sbjct: 663  DCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIP--------------- 707

Query: 1696 AVGIIFFTTYIIISFLIMVNMYIAVILENF----NVATEESTE 1734
                 F+   I+I  L+++ +++A++  +F    +V  EE+ E
Sbjct: 708  -----FYLMVILIGNLLVLYLFLALV-SSFSSCKDVTAEENNE 744



 Score = 68.2 bits (165), Expect = 8e-11
 Identities = 70/302 (23%), Positives = 126/302 (41%), Gaps = 56/302 (18%)

Query: 119  IRRTAIKVSVHSWFSLFITVTILVNCVCMTRTD-----------LPEKIEYVFTVIYTFE 167
            IR+T  K+  ++WF  FI +  L++   +   D           L E  + +FT I+  E
Sbjct: 923  IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982

Query: 168  ALIKILARGFCLNEFTYLRDPWNWLDFSVIT---LAYVGTAIDLRGISGLRTFRVLRALK 224
             L+K +A GF      Y  + W  LDF V+    L+ +G   +   +  L + + LR L+
Sbjct: 983  MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTRE--ELKPLISMKFLRPLR 1036

Query: 225  TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVN 284
             +S    +KV+V ALI +     +V ++ +    +F+++G+ LF G    +C+       
Sbjct: 1037 VLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRF-YECIDPT---- 1091

Query: 285  ETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAW 344
                 S  R P   +  +   + LL                    +N   N   FD+   
Sbjct: 1092 -----SGERFPSSEVMNKSRCESLLFNES-------------MLWENAKMN---FDNVGN 1130

Query: 345  AFLSLFRLMTQDSWERLYQQTLRTSG---------KIYM-IFFVLVIFLGSFYLVNLILA 394
             FLSL ++ T + W  +    + +            IYM  +F+  I  G F  +++++ 
Sbjct: 1131 GFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLIT 1190

Query: 395  VV 396
            V+
Sbjct: 1191 VI 1192



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 37/199 (18%)

Query: 115  PFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMT-RTDLPEK--------IEYVFTVIYT 165
            P N ++     V     F++ + V I    + M   TD+           I  +F ++YT
Sbjct: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYT 1295

Query: 166  FEALIKILA-RGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGL---------- 214
             E ++K++A R F      Y    WN  DF V+  +  G  + +   S L          
Sbjct: 1296 MECILKLIAFRCF------YFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLIL 1349

Query: 215  --RTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
              R   +LR  K   V   L +    L+ S+  L ++ +L    + ++A+ G+  F    
Sbjct: 1350 LSRIIHMLRLGKGPKVFHNLML---PLMLSLPALLNIILLIFLVMFIYAVFGMYNF---- 1402

Query: 273  KNKCVKNDMAVNETTNYSS 291
                VK +  +N+ +N+ +
Sbjct: 1403 --AYVKKEAGINDVSNFET 1419



 Score = 39.7 bits (91), Expect = 0.029
 Identities = 37/182 (20%), Positives = 86/182 (47%), Gaps = 18/182 (9%)

Query: 661 LVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA-- 718
           ++  PF +L I + ++++ +FM++ +    P +  +L+  N +  I +T E++ K+ A  
Sbjct: 114 VLVHPFFQLFILISVLIDCVFMSLTN---LPKWRPVLE--NTLLGI-YTFEILVKLFARG 167

Query: 719 --FDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTL 776
                + +    WN  D   VTV  + +  +    +  L++ R LR+ K+      L +L
Sbjct: 168 VWAGSFSFLGDPWNWLD-FSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226

Query: 777 IKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFF 836
           + ++ + +  L  + I+    + +F+L+G  L   N ++           WP+ + ++  
Sbjct: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFR-------WPQENENETL 279

Query: 837 HS 838
           H+
Sbjct: 280 HN 281


>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
            type V, alpha (long QT syndrome 3) [Homo sapiens]
          Length = 1637

 Score = 1000 bits (2586), Expect = 0.0
 Identities = 486/598 (81%), Positives = 539/598 (90%), Gaps = 3/598 (0%)

Query: 1170 AFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNIS 1229
            AFED YL+++ T+K LLEY D++FT++FV EMLLKWVAYGFKKYFTNAWCWLDFLIV++S
Sbjct: 832  AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVS 891

Query: 1230 LISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCL 1289
            L+SL A  L ++E+ PIK+LRTLRALRPLRALSRFEGMRVVV+ALVGAIPSIMNVLLVCL
Sbjct: 892  LVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCL 951

Query: 1290 IFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVN 1349
            IFWLIFSIMGVNLFAGKF RCIN T+G+  L   +IVNNKS C+  N TG  +W  VKVN
Sbjct: 952  IFWLIFSIMGVNLFAGKFGRCINQTEGDLPL-NYTIVNNKSQCESLNLTGELYWTKVKVN 1010

Query: 1350 FDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFT 1409
            FDNV  GYLALLQVATFKGWMDIMYAAVDSR    QP+WE N+YMY+YFVIFIIFG FFT
Sbjct: 1011 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT 1070

Query: 1410 LNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFV 1469
            LNLF+GVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK+QGF+
Sbjct: 1071 LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130

Query: 1470 FDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFA 1529
            FDIVT+QAFD+TIM LICLNM+TMMVETDDQS EK  IL KIN  FVA+FTGEC++K+ A
Sbjct: 1131 FDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAA 1190

Query: 1530 LRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589
            LR YYFTN WN+FDF+VV+LSI   + S I++  + +FSPTLFRVIRLARIGRILRLIR 
Sbjct: 1191 LRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQ--KYFFSPTLFRVIRLARIGRILRLIRG 1248

Query: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFAN 1649
            AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM++F +V+WEAGIDDMFNFQTFAN
Sbjct: 1249 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFAN 1308

Query: 1650 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIIS 1709
            SMLCLFQITTSAGWDGLLSPILNTGPPYCDP LPNSNG+RGDCGSPAVGI+FFTTYIIIS
Sbjct: 1309 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1368

Query: 1710 FLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDF 1767
            FLI+VNMYIA+ILENF+VATEESTEPLSEDDFDMFYE WEKFDPEATQFI +S  + F
Sbjct: 1369 FLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSCGTRF 1426



 Score =  617 bits (1590), Expect = e-176
 Identities = 351/624 (56%), Positives = 423/624 (67%), Gaps = 41/624 (6%)

Query: 10  TNNFRRFTPESLVEIEKQIAAKQGTKKAR-EKHREQKDQEEKPRPQLDLKACNQLPKFYG 68
           T++FRRFT ESL  IEK++A KQ       ++ RE   +EE PRPQLDL+A  +LP  YG
Sbjct: 10  TSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYG 69

Query: 69  ELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSV 128
             P ELIGEPLEDLDPFYST +TF+VLNKG+TI RFSAT AL++ SPF+ IRR A+K+ V
Sbjct: 70  NPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILV 129

Query: 129 HSWFSLFITVTILVNCVCMTRTDLP---EKIEYVFTVIYTFEALIKILARGFCLNEFTYL 185
           HS F++ I  TIL NCV M + D P   + +EY FT IYTFE+L+KILARGFCL+ FT+L
Sbjct: 130 HSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFL 189

Query: 186 RDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKK 245
           RDPWNWLDFSVI +AY    +DL  +S LRTFRVLRALKT+SVI GLK IVGALI SVKK
Sbjct: 190 RDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKK 249

Query: 246 LADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTN--------------YSS 291
           LADV +LT+FCLSVFAL+GLQLF GNL++KCV+N  A+N T                Y S
Sbjct: 250 LADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLS 309

Query: 292 HRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFR 351
              P+ Y+ K GTSD LLCGN SD+G CP+GY CLK  +NPD  YTSFDSFAWAFL+LFR
Sbjct: 310 D--PENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFR 367

Query: 352 LMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEI 411
           LMTQD WERLYQQTLR++GKIYMIFF+LVIFLGSFYLVNLILAVV MAYEEQNQAT  E 
Sbjct: 368 LMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAET 427

Query: 412 EAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGST 471
           E KEK+FQEA+EML+KE E L   G+DT S  S   SPL   N+ ERR + + R+S G+ 
Sbjct: 428 EEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTE 487

Query: 472 E--DNKSPRSDPYN-QRRMSFLGLASG------KRRASHGSVFHFRSPGRDI-SLPEGVT 521
           E  +++ P+SD  +  R M+ L L  G      K R+S GS+F FR   RD+ S  +   
Sbjct: 488 ECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR--RDLGSEADFAD 545

Query: 522 DDGVFPGDHESHRGSLLLGGGAGQQGPLPR-SPLPQPSNPDSRHGEDEHQPPPTSELAPG 580
           D+    G+ ESH  SLL+        PL R S   QPS   S  G   H    ++    G
Sbjct: 546 DENSTAGESESHHTSLLV------PWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNG 599

Query: 581 AVDVSAFDAGQKKTFLSAEYLDEP 604
              VS   AG  +      +L  P
Sbjct: 600 V--VSLLGAGDPEATSPGSHLLRP 621



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 82/349 (23%), Positives = 156/349 (44%), Gaps = 67/349 (19%)

Query: 1141 VRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFE 1200
            +R+   +I+ HS F   I+  IL +   +A  D      P     +EYT   FT I+ FE
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHD-----PPPWTKYVEYT---FTAIYTFE 171

Query: 1201 MLLKWVAYGFK----KYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALR 1256
             L+K +A GF      +  + W WLDF ++      + A   E+ ++  + ALRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225

Query: 1257 PLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-------WR 1309
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G         + 
Sbjct: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1310 CINYTDGEF---SLVPLSI---VNNKSDCKIQNSTGSFFWVNVK---------------- 1347
             +N T+G      LV  S+   +++  +  ++N T                         
Sbjct: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345

Query: 1348 -------VNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVI 1400
                    +FD+ A  +LAL ++ T   W  +    + S            +YM ++F++
Sbjct: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRS---------AGKIYM-IFFML 395

Query: 1401 FIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1449
             I  G F+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 396  VIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 72/293 (24%), Positives = 137/293 (46%), Gaps = 48/293 (16%)

Query: 152  LPEKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG- 210
            L E  + +FT ++  E L+K +A GF      Y  + W WLDF ++ ++ V    +  G 
Sbjct: 847  LLEYADKMFTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGF 902

Query: 211  -----ISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGL 265
                 I  LRT R LR L+ +S   G++V+V AL+ ++  + +V ++ +    +F+++G+
Sbjct: 903  AEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGV 962

Query: 266  QLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYIC 325
             LF G       K    +N+T       + D+ +N    ++   C + + +G        
Sbjct: 963  NLFAG-------KFGRCINQT-------EGDLPLNYTIVNNKSQCESLNLTGE----LYW 1004

Query: 326  LKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSW---------ERLYQQTLRTSGKIYM-I 375
             K   N       FD+    +L+L ++ T   W          R Y++  +    +YM I
Sbjct: 1005 TKVKVN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1057

Query: 376  FFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDE---IEAKEKKFQEALEML 425
            +FV+ I  GSF+ +NL + V+   + +Q +    +   +  ++KK+  A++ L
Sbjct: 1058 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1110



 Score = 85.1 bits (209), Expect = 6e-16
 Identities = 69/284 (24%), Positives = 135/284 (47%), Gaps = 41/284 (14%)

Query: 653  KLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEM 712
            K +  +F +VT    ++TI   I +N + M +E    SP    +L   N++F   FT E 
Sbjct: 1125 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1184

Query: 713  VFKIIAFDPYYYFQKKWNIFDCIIVTVSLLEL---GVAKKGSLS-----VLRSFRLLRVF 764
            + K+ A   +YYF   WNIFD ++V +S++      + +K   S     V+R  R+ R+ 
Sbjct: 1185 IVKLAAL-RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRIL 1243

Query: 765  KLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPH 824
            +L +    + TL+  +  S+ AL N+ ++L +++F++++ G  +    Y      I    
Sbjct: 1244 RLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFG--MANFAYVKWEAGID--- 1298

Query: 825  EDWPRWHMHDFFHSFLIVFRILCGEWIENMWACM--------------------EVGQKS 864
                 ++   F +S L +F+I      + + + +                    + G  +
Sbjct: 1299 ---DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPA 1355

Query: 865  ICLILFLTVMVLGNLVVLNLFIALLLNSFS--ADNLTAP--EDD 904
            + ++ F T +++  L+V+N++IA++L +FS   +  T P  EDD
Sbjct: 1356 VGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDD 1399



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 80/233 (34%), Positives = 100/233 (42%), Gaps = 37/233 (15%)

Query: 881  VLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQ---VFGHRTKQALCSFFSRSCP 937
            VLNLF+ALLL+SFSADNLTAP++D E+NNLQ+ALARIQ    F  RT    C    R  P
Sbjct: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690

Query: 938  FPQPKA-----EPELVVKLPLSSSKAENHIAANTAR------GSSGGLQAPRGPRDEHSD 986
              +P A     +    +  P S    E      T +      G   G   P  P      
Sbjct: 691  -QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP---- 745

Query: 987  FIANPTVWVSVPIAEGESDLDDLEDD-----GGEDAQSFQQEVIPKGQQEQLQQVERCGD 1041
                    V VPIA  ESD DD E+D     G E+  S QQE  P     +     R   
Sbjct: 746  --------VCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWS 797

Query: 1042 HLTPRSPGTGTSSEDLAPSLGETWKDESVPQVP--AEGVDDTSSSEGSTVDCL 1092
             ++  +     +S   A    + WK E  PQ P   E  +D    E  T+  L
Sbjct: 798  QVSATASSEAEASASQA-DWRQQWKAE--PQAPGCGEAFEDIYLEERKTIKVL 847



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 51/241 (21%), Positives = 108/241 (44%), Gaps = 38/241 (15%)

Query: 692  TFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLE-----LGV 746
            T + +L+  + +FT  F  EM+ K +A+    YF   W   D +IV VSL+      LG 
Sbjct: 843  TIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGF 902

Query: 747  AKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGK 806
            A+ G +  LR+ R LR  +    +  +  ++  +  ++ ++ N+ ++  I   +F+++G 
Sbjct: 903  AEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGV 962

Query: 807  QL---------------LGENYR--NNRKNISAPHED----WPRWHMH--DFFHSFLIVF 843
             L               L  NY   NN+    + +      W +  ++  +    +L + 
Sbjct: 963  NLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALL 1022

Query: 844  RILCGE-WIENMWACMEV---------GQKSICLILFLTVMVLGNLVVLNLFIALLLNSF 893
            ++   + W++ M+A ++                 I F+  ++ G+   LNLFI +++++F
Sbjct: 1023 QVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNF 1082

Query: 894  S 894
            +
Sbjct: 1083 N 1083



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 11/151 (7%)

Query: 669 LTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA----FDPYYY 724
           + I   I+ N +FMA   H   P  + +       FT  +T E + KI+A       + +
Sbjct: 135 MLIMCTILTNCVFMAQ--HDPPPWTKYV----EYTFTAIYTFESLVKILARGFCLHAFTF 188

Query: 725 FQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSV 784
            +  WN  D  ++ ++     V   G++S LR+FR+LR  K       L T++  +  SV
Sbjct: 189 LRDPWNWLDFSVIIMAYTTEFV-DLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSV 247

Query: 785 GALGNLTIILAIIVFVFALVGKQLLGENYRN 815
             L ++ ++    + VFAL+G QL   N R+
Sbjct: 248 KKLADVMVLTVFCLSVFALIGLQLFMGNLRH 278



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 39/168 (23%), Positives = 78/168 (46%), Gaps = 25/168 (14%)

Query: 116  FNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYV------FTVIYTFEAL 169
            F+++ + A  V++     +F+    +V  +  T    PEKI  +      F  I+T E +
Sbjct: 1131 FDIVTKQAFDVTI-----MFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1185

Query: 170  IKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAI---------DLRGISGLRTFRVL 220
            +K+ A    L  + Y  + WN  DF V+ L+ VGT +                +R  R+ 
Sbjct: 1186 VKLAA----LRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIG 1240

Query: 221  RALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLF 268
            R L+ +    G++ ++ AL+ S+  L ++ +L    + ++++ G+  F
Sbjct: 1241 RILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1288



 Score = 33.5 bits (75), Expect = 2.1
 Identities = 20/85 (23%), Positives = 43/85 (50%), Gaps = 1/85 (1%)

Query: 835 FFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFS 894
           F  +FL +FR++  +  E ++         I +I F+ V+ LG+  ++NL +A++  ++ 
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 895 ADN-LTAPEDDGEVNNLQVALARIQ 918
             N  T  E + +    Q A+  ++
Sbjct: 418 EQNQATIAETEEKEKRFQEAMEMLK 442


>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform a [Homo sapiens]
          Length = 2223

 Score =  523 bits (1347), Expect = e-148
 Identities = 450/1769 (25%), Positives = 768/1769 (43%), Gaps = 239/1769 (13%)

Query: 120  RRTAIKVSVHSWFSLFITVTILVNCV------------CMT-RTDLPEKIEYVFTVIYTF 166
            R   IK+  + WF     + IL+NCV            C++ R  + +  +    + +  
Sbjct: 69   RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAM 128

Query: 167  EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGI--SGLRTFRVLRALK 224
            E ++K++A G    +  YL D WN LDF ++    V  ++DL+ I  S +RT RVLR LK
Sbjct: 129  EMVLKMVALGI-FGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 187

Query: 225  TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVN 284
             ++ +P ++++V  L+ ++  L +V +L  F   +F ++G+QL+ G L+N+C   +    
Sbjct: 188  AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEE---- 243

Query: 285  ETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSG---------------HC----PDGY-- 323
              T       P  Y  +     P +C    D+G                C     D Y  
Sbjct: 244  NFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDF 303

Query: 324  ---------------------ICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY 362
                                 +C   S NP     +FD+  +A++ +F+++T + W  + 
Sbjct: 304  GAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIM 363

Query: 363  QQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQ----------------- 405
               +        I+F+L+I +GSF+++NL L V+   + E  Q                 
Sbjct: 364  YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSS 423

Query: 406  ---ATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGS--PLTSKNASERRH 460
               +  +  +  E+ FQ    +LRK +    ALG+   +L S   +  P     A    H
Sbjct: 424  TVASYAEPGDCYEEIFQYVCHILRKAKR--RALGL-YQALQSRRQALGPEAPAPAKPGPH 480

Query: 461  RIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGV 520
              +PR   G T+                   L S   +  HG      SPG D S  E  
Sbjct: 481  AKEPRHYHGKTKGQGDEGRH-----------LGSRHCQTLHGPA----SPGNDHSGRELC 525

Query: 521  TDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPG 580
                  P D   H              P+P +    P++      ED  +P        G
Sbjct: 526  PQHS--PLDATPHT----------LVQPIPATLASDPASCPCCQHEDGRRPSGL-----G 568

Query: 581  AVDVSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQ 640
            + D     +G   +    +  D       A S     +S L + EE E++          
Sbjct: 569  STDSGQEGSGSGSSAGGEDEAD----GDGARSSEDGASSELGKEEEEEEQADGA------ 618

Query: 641  KYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIG 700
               +W C  +W + +  L G+V   +    I + I+VNT+ M +EHH        +L+I 
Sbjct: 619  ---VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEIC 675

Query: 701  NIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRL 760
            N+VFT  F  EM+ K+ AF  + Y +  +NIFD IIV +S+ E+     G LSVLR+FRL
Sbjct: 676  NVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRL 735

Query: 761  LRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNI 820
            LRV KL +  P L   + ++  ++  +    ++L + +F+F+++G  + G  + + R + 
Sbjct: 736  LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF-SLRTDT 794

Query: 821  SAPHEDWPRWHMHDFFHSFLIVFRILCGE-WIENMWACMEVGQKSICLILFLTVMVLGNL 879
                 D  R +      + + VF+IL  E W   ++  M         + F+ +M  GN 
Sbjct: 795  GDTVPD--RKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSPWASLYFVALMTFGNY 851

Query: 880  VVLNLFIALLLNSFSAD---NLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSF----- 931
            V+ NL +A+L+  F A+   N +  ++D   +N++      +         LC       
Sbjct: 852  VLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPN 911

Query: 932  --FSRSCPF-----------PQPKA----EPELVVKLPLSSSKAENHIAANTARGSSGGL 974
                 S P            P P+     +P LV      SS       +   R  S   
Sbjct: 912  GHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSR 971

Query: 975  QAPRGPRDEHSDFIANPTVWVSV----PIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQ 1030
             +  GP    + + +  + W S+    P AE ES L      G    +    E  P+   
Sbjct: 972  SSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAP 1031

Query: 1031 EQLQQVERC--GDHLTPRSPG-------TGTSSEDLA---PSLGETWKDESVPQVPAEGV 1078
                       G HL  R              S DLA   P++G   +       PA G 
Sbjct: 1032 LHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGH 1091

Query: 1079 DDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPW--- 1135
            +D +    S       +++  K+ +  D  E+ ++     C R      +D  K  W   
Sbjct: 1092 EDCNGRMPSIA-----KDVFTKMGDRGDRGEDEEEIDYTLCFRVRKM--IDVYKPDWCEV 1144

Query: 1136 DVGWQV---------RKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALL 1186
               W V         R  C  I+ H  F+  ++  I L+  ++A E   ++   T +  L
Sbjct: 1145 REDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFL 1204

Query: 1187 EYTDRVFTFIFVFEMLLKWVA----YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSE 1242
              ++ +FT IFV EM LK V+    +G + Y  ++W  LD  +V +S+I +   +     
Sbjct: 1205 TVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGG 1264

Query: 1243 ---VAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMG 1299
               +  ++ LR LR LRPLR +SR  G+++VV+ L+ ++  I N++L+C  F++IF I+G
Sbjct: 1265 AKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILG 1324

Query: 1300 VNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLA 1359
            V LF GKF+ C+         V    + N+SDC   N    + WV+ K NFDN+    ++
Sbjct: 1325 VQLFKGKFYHCLG--------VDTRNITNRSDCMAAN----YRWVHHKYNFDNLGQALMS 1372

Query: 1360 LLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIID 1419
            L  +A+  GW++IMY  +D+  V+ QP    N +M LYF+ F++   FF LN+FVGV+++
Sbjct: 1373 LFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVE 1432

Query: 1420 NFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFD 1479
            NF++ ++    ++    EE  K    ++K   K  + P        +  +  + T    D
Sbjct: 1433 NFHKCRQHQEAEEARRREE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLD 1490

Query: 1480 ITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKM--FALRQYYFTN 1537
            I I  +ICLN++TM +E  +Q       L   N  F  VF  E V+K+  F LR+ +F +
Sbjct: 1491 IFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRR-FFKD 1549

Query: 1538 GWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLL 1597
             WN  D  +V+LS+  +    I  +     +PT+ R++R+ RI R+L+L++ A G+R LL
Sbjct: 1550 RWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALL 1609

Query: 1598 FALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWE-----AGIDDMFNFQTFANSML 1652
              ++ +LP + N+GLL  L+ FIY+  G+  F  +         G+     F+ F  + L
Sbjct: 1610 DTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFL 1669

Query: 1653 CLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPA--VGIIFFTTYIIISF 1710
             LFQ++T   W+G++   L            +       C S    V  ++F ++++ + 
Sbjct: 1670 TLFQVSTGDNWNGIMKDTLR-----------DCTHDERSCLSSLQFVSPLYFVSFVLTAQ 1718

Query: 1711 LIMVNMYIAVILENFNVATEESTEPLSED 1739
             +++N+ +AV++++ + + +E+ E    D
Sbjct: 1719 FVLINVVVAVLMKHLDDSNKEAQEDAEMD 1747



 Score =  108 bits (270), Expect = 5e-23
 Identities = 85/355 (23%), Positives = 153/355 (43%), Gaps = 68/355 (19%)

Query: 109  ALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMT------RTDLPEKI-----E 157
            +++LFSP N  R     +  H  F   +   I +NC+ +            E+I      
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208

Query: 158  YVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---- 213
            Y+FT I+  E  +K+++ G    E  YLR  WN LD  ++ ++ +   + L    G    
Sbjct: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268

Query: 214  -----LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLF 268
                 LR  R LR L+ +S  PGLK++V  LI S+K + ++ ++      +F ++G+QLF
Sbjct: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328

Query: 269  KGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKT 328
            KG   + C+  D     T N +                     N SD         C+  
Sbjct: 1329 KGKFYH-CLGVD-----TRNIT---------------------NRSD---------CMAA 1352

Query: 329  SDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFV 378
            +     +  +FD+   A +SLF L ++D W  +           QQ +       +++F+
Sbjct: 1353 NYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFI 1412

Query: 379  LVIFLGSFYLVNLILAVVTMAYEE--QNQATTDEIEAKEKKFQEALEMLRKEQEV 431
              + + SF+++N+ + VV   + +  Q+Q   +    +EK+ +   +  RK Q +
Sbjct: 1413 SFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRL 1467



 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 73/285 (25%), Positives = 133/285 (46%), Gaps = 36/285 (12%)

Query: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531
            IV  + F+  IM+ I +N ++M +E  +Q EE T IL   N  F ++F  E ++K+ A  
Sbjct: 636  IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 695

Query: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590
             + Y  N +N+FD I+V++SI  ++  A               V+R  R+ R+L+L+R  
Sbjct: 696  LFDYLRNPYNIFDSIIVIISIWEIVGQA----------DGGLSVLRTFRLLRVLKLVRFM 745

Query: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFP---HVRWEAG--IDDMFNFQ 1645
              +R  L  LM ++  +    +LL L +FI+SI GM  F     +R + G  + D  NF 
Sbjct: 746  PALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 805

Query: 1646 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTY 1705
            +   +++ +FQI T   W+ +L   + +  P+                      ++F   
Sbjct: 806  SLLWAIVTVFQILTQEDWNVVLYNGMASTSPWAS--------------------LYFVAL 845

Query: 1706 IIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEK 1750
            +     ++ N+ +A+++E F    + +     ED      E ++K
Sbjct: 846  MTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 890



 Score = 97.8 bits (242), Expect = 9e-20
 Identities = 79/245 (32%), Positives = 117/245 (47%), Gaps = 39/245 (15%)

Query: 1099 RKIPELADDLEEPDDCFTEGCIRHCP----------CCKLDTTKSPWDVGWQVRKTCYRI 1148
            R  P     LEEP D    G   H P          C +  T+   W         C ++
Sbjct: 29   RSPPSSPPGLEEPLD----GADPHVPHPDLAPIAFFCLRQTTSPRNW---------CIKM 75

Query: 1149 VEHSWFESFIIFMILLSSGSLAFEDYYLDQ---KPTVKALLEYTDRVFTFIFVFEMLLKW 1205
            V + WFE   + +ILL+  +L       D        K L  + D +F F F  EM+LK 
Sbjct: 76   VCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FAMEMVLKM 134

Query: 1206 VA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALS 1262
            VA   +G K Y  + W  LDF IV   ++  +  +   +    + A+RT+R LRPL+A++
Sbjct: 135  VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRPLKAIN 190

Query: 1263 RFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RCI---NYT-DGE 1317
            R   MR++V+ L+  +P + NVLL+C   + IF I+GV L+AG    RC    N+T  G+
Sbjct: 191  RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGD 250

Query: 1318 FSLVP 1322
             +L P
Sbjct: 251  VALPP 255



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 75/319 (23%), Positives = 147/319 (46%), Gaps = 29/319 (9%)

Query: 622  EELEESEQKCPPCLTSLSQKYLIWDCCPMWVKL---KTILFGLVTDPFAELTITLCIVVN 678
            +E EE+ ++    L  L +K       P +      + ++  + T  + ++ IT  I +N
Sbjct: 1441 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN 1500

Query: 679  TIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVT 738
             + M++EH+    + E  L+  N +FT  F  E V K++AF    +F+ +WN  D  IV 
Sbjct: 1501 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL 1560

Query: 739  VSL-------LELGVA---KKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 788
            +S+       +E+  A       + ++R  R+ RV KL K    +  L+  +  ++  +G
Sbjct: 1561 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1620

Query: 789  NLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHDFFHSFLIVFRILC 847
            NL ++  ++ F++A +G +L G+   N+      P E   R     +F  +FL +F++  
Sbjct: 1621 NLGLLFMLLFFIYAALGVELFGKLVCNDEN----PCEGMSRHATFENFGMAFLTLFQVST 1676

Query: 848  GE-WIENMWACME--VGQKSICL--------ILFLTVMVLGNLVVLNLFIALLLNSFSAD 896
            G+ W   M   +      +  CL        + F++ ++    V++N+ +A+L+      
Sbjct: 1677 GDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736

Query: 897  NLTAPEDDGEVNNLQVALA 915
            N  A ED      L++ +A
Sbjct: 1737 NKEAQEDAEMDAELELEMA 1755



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 81/339 (23%), Positives = 149/339 (43%), Gaps = 78/339 (23%)

Query: 106 ATRALWLFSPFNLIRRTAIKVSVHS-WFSLFITVTILVNCVCM---------TRTDLPEK 155
           A  A+WL        R  ++  V S +F+  I + ILVN V M           T++ E 
Sbjct: 615 ADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEI 674

Query: 156 IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAY---VGTAIDLRGIS 212
              VFT ++  E ++K+ A G     F YLR+P+N  D  ++ ++    VG A    G+S
Sbjct: 675 CNVVFTSMFALEMILKLAAFGL----FDYLRNPYNIFDSIIVIISIWEIVGQADG--GLS 728

Query: 213 GLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
            LRTFR+LR LK V  +P L+  +  L+ ++  +A   +L +  + +F+++G+ +F    
Sbjct: 729 VLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF 788

Query: 273 KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332
             +    D              PD     R   D LL                       
Sbjct: 789 SLRTDTGDTV------------PD-----RKNFDSLL----------------------- 808

Query: 333 DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLI 392
                      WA +++F+++TQ+ W  +    + ++     ++FV ++  G++ L NL+
Sbjct: 809 -----------WAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLL 857

Query: 393 LAVVTMAYE---EQNQATTDEIEAKEK-----KFQEALE 423
           +A++   ++   + N++ +DE ++        K QE L+
Sbjct: 858 VAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLD 896


>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
            isoform 5 [Homo sapiens]
          Length = 2321

 Score =  426 bits (1095), Expect = e-118
 Identities = 324/1150 (28%), Positives = 551/1150 (47%), Gaps = 132/1150 (11%)

Query: 671  ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWN 730
            I + I+VNT+ M +E+H         L+I NIVFT  F  EM+ K++ + P+ Y +  +N
Sbjct: 749  IMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808

Query: 731  IFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 790
            IFD +IV +S+ E+   + G LSVLR+FRL+RV KL +  P L   + ++  ++  +   
Sbjct: 809  IFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868

Query: 791  TIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGE- 849
             ++L + +F+F+++G  L G  + + R   + P     R +      + + VF+IL  E 
Sbjct: 869  CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPD----RKNFDSLLWAIVTVFQILTQED 924

Query: 850  WIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPED-DGEVN 908
            W + ++  M     S   + F+ +M  GN V+ NL +A+L+  F A+ ++  ED  G+++
Sbjct: 925  WNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLS 983

Query: 909  NLQVALARIQVFGHRTKQALCSFFSRSC------------------PFPQPKAEPELVV- 949
             +Q+ +   Q       ++   FFS S                   P  +    P L++ 
Sbjct: 984  CIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1042

Query: 950  ------KLPLSSSKAENHIAANTARGSSGGLQAPRGPRDE-----------HSDFIANPT 992
                   LP S+S          +R +S    A  G   E           HS + A  +
Sbjct: 1043 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102

Query: 993  VWVSVPIAE---GESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCG----DHLTP 1045
             W S   +    G +         GE       E      +E+  + ER      DH   
Sbjct: 1103 -WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHR 1161

Query: 1046 RS-PGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTV---DCLDPEEILRKI 1101
             S      SS DL  +L          QVP  G+  T+S  GS     DC       R  
Sbjct: 1162 GSLEREAKSSFDLPDTL----------QVP--GLHRTASGRGSASEHQDCNGKSASGRLA 1209

Query: 1102 PELADDLE--EPDDCFTEGCIR-----------HCPCCKLDTTKSPWDV-----GWQVRK 1143
              L  D    + DD   EG +              P C L+  +  W         + R 
Sbjct: 1210 RALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLE--RDSWSAYIFPPQSRFRL 1267

Query: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
             C+RI+ H  F+  ++ +I L+  ++A E   +D     +  L  ++ +FT +F+ EM +
Sbjct: 1268 LCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTV 1327

Query: 1204 KWVAYGF----KKYFTNAWCWLDFLIVNISLISLTAKILEYSE---VAPIKALRTLRALR 1256
            K VA G+    + Y  ++W  LD L+V IS+I +   ++  S    +  ++ LR LR LR
Sbjct: 1328 KVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLR 1387

Query: 1257 PLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDG 1316
            PLR +SR +G+++VV+ L+ ++  I N++++C  F++IF I+GV LF GKF+ C     G
Sbjct: 1388 PLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QG 1443

Query: 1317 EFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAA 1376
            E +      + NKSDC    +  S+ WV  K NFDN+    ++L  +A+  GW+DIMY  
Sbjct: 1444 EDT----RNITNKSDC----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDG 1495

Query: 1377 VDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMT 1436
            +D+  V+ QP    N +M LYF+ F++   FF LN+FVGV+++NF++ ++    ++    
Sbjct: 1496 LDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RR 1554

Query: 1437 EEQKKYYNAMKKLGSKKPQ------KPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNM 1490
             E+K+     KK  SK+ Q      KP     ++F+  V  + T    D+ I  +I LN+
Sbjct: 1555 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNV 1614

Query: 1491 ITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVVL 1549
            +TM +E   Q +   + L   N  F  +F  E V K+ A   + +F + WN  D  +V+L
Sbjct: 1615 VTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLL 1674

Query: 1550 SIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFN 1609
            SI  +    I  +     +PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N
Sbjct: 1675 SIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1734

Query: 1610 IGLLLFLVMFIYSIFGMSSFPHVRWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWD 1664
            +GLL  L+ FI++  G+  F  +  +      G+     F+ F  + L LF+++T   W+
Sbjct: 1735 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWN 1794

Query: 1665 GLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILEN 1724
            G++   L      CD            C +  +  I+F ++++ +  ++VN+ IAV++++
Sbjct: 1795 GIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKH 1842

Query: 1725 FNVATEESTE 1734
               + +E+ E
Sbjct: 1843 LEESNKEAKE 1852



 Score =  128 bits (321), Expect = 6e-29
 Identities = 112/380 (29%), Positives = 171/380 (45%), Gaps = 95/380 (25%)

Query: 1142 RKTCYRIVEHSWFESFIIFMILLSSGSLAF----EDYYLDQKPTVKALLEYTDRVFTFIF 1197
            R  C R V + WFE   + +ILL+  +L      ED   D +   + L  + D +F F F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFAF-F 128

Query: 1198 VFEMLLKWVA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIKALRT 1251
              EM++K VA   +G K Y  + W  LDF IV        A +LEYS   +     A+RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RC 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    RC
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241

Query: 1311 INYTDGEFSLVPLSI----------------------VNNKSDCK--------------- 1333
              +    FSL PLS+                       N    C+               
Sbjct: 242  --FLPENFSL-PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPC 298

Query: 1334 -----IQNSTGSFFWVNVKVNFDNVAMG-----------------YLALLQVATFKGWMD 1371
                   NS+ +   VN    + N + G                 ++A+ QV T +GW+D
Sbjct: 299  GLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 1372 IMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ 1431
            IMY  +D+           + Y ++YF++ II G FF +NL + VI   F++ K++   +
Sbjct: 359  IMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---E 405

Query: 1432 DIFMTEEQKKYYNAMKKLGS 1451
               M E++ ++ +    L S
Sbjct: 406  SQLMREQRVRFLSNASTLAS 425



 Score =  124 bits (311), Expect = 9e-28
 Identities = 186/899 (20%), Positives = 344/899 (38%), Gaps = 191/899 (21%)

Query: 105  SATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCM---------TRTDLPEK 155
            S+  A W      LI  T  K+    +F   I + ILVN + M           T+  E 
Sbjct: 723  SSVLAFW-----RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEI 777

Query: 156  IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG--ISG 213
               VFT ++  E L+K+L  G     F Y+++P+N  D  VI +  V   +  +G  +S 
Sbjct: 778  SNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSV 832

Query: 214  LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLK 273
            LRTFR++R LK V  +P L+  +  L+ ++  +A   +L +  + +F+++G+ LF     
Sbjct: 833  LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---- 888

Query: 274  NKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPD 333
                           ++S R  D   +++                               
Sbjct: 889  -------------CKFASERDGDTLPDRK------------------------------- 904

Query: 334  FNYTSFDSFAWAFLSLFRLMTQDSWER--------------LYQQTLRTSGKIYMIFFVL 379
                +FDS  WA +++F+++TQ+ W +              LY   L T G   +   ++
Sbjct: 905  ----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 380  VIFLGSFYLVNLI--------LAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEV 431
             I +  F    +         L+ + +  + Q     ++ E++   F  +L+     ++ 
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQG-GDANKSESEPDFFSPSLDGDGDRKKC 1019

Query: 432  LAALGI-DTTSLHSHNGSPLTSKNAS--------------------ERRHRIKPRVSEGS 470
            LA + + +   L      PL    A+                     RR         G+
Sbjct: 1020 LALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGA 1079

Query: 471  TEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDH 530
              + KSP S   +         +   RR+S  S+   R+P      P G           
Sbjct: 1080 AHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLG--RAPSLKRRSPSG----------- 1126

Query: 531  ESHRGSLLLGGGAGQQGPLPRSPLPQ--PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFD 588
               R SLL G G   Q     S   +  P+  D RH     +   +S   P  + V    
Sbjct: 1127 --ERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLH 1184

Query: 589  AGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIW--- 645
                    ++E+ D     + A   ++      +   + +        S  ++   W   
Sbjct: 1185 RTASGRGSASEHQD--CNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRA 1242

Query: 646  ---DCC-----------PMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP 691
                CC           P   + + +   ++T    +  + + I +N I +AME   + P
Sbjct: 1243 RLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDP 1302

Query: 692  --TFEAMLQIGNIVFTIFFTAEMVFKIIA----FDPYYYFQKKWNIFDCIIVTVSLLEL- 744
                   L + N +FT  F AEM  K++A    F    Y +  WN+ D ++V +S++++ 
Sbjct: 1303 HSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDIL 1362

Query: 745  -------GVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
                   G    G L VLR  R LR  ++      L  +++ + +S+  +GN+ +I    
Sbjct: 1363 VSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAF 1422

Query: 798  VFVFALVGKQLL--------GENYRN--NRKNISAPHEDWPRWHMHDF--FHSFLIVFRI 845
              +F ++G QL         GE+ RN  N+ + +     W R H ++F      L+   +
Sbjct: 1423 FIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVR-HKYNFDNLGQALMSLFV 1481

Query: 846  LCGE--WIENMWACME---VGQKSI------CLILFLTVMVLGNLVVLNLFIALLLNSF 893
            L  +  W++ M+  ++   V Q+ I       L+ F++ +++    VLN+F+ +++ +F
Sbjct: 1482 LASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  118 bits (296), Expect = 5e-26
 Identities = 82/347 (23%), Positives = 158/347 (45%), Gaps = 49/347 (14%)

Query: 120 RRTAIKVSVHSWFSLFITVTILVNCVCM-------------TRTDLPEKIEYVFTVIYTF 166
           R   ++   + WF     + IL+NCV +              R  + +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGIS--GLRTFRVLRALK 224
           E ++K++A G    +  YL D WN LDF ++    +  ++DL+ +S   +RT RVLR L+
Sbjct: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKND---- 280
            ++ +P ++++V  L+ ++  L +V +L  F   +F +VG+QL+ G L+N+C   +    
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 281 -MAVNETTNYSSHRK---PDIYINKRGT------SDPLLCGNGSDSGHCPDGYICLKTSD 330
            ++V+    Y +  +   P I    R        S P L G+G     C   Y    +S 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS 309

Query: 331 -------------------NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK 371
                              NP     +FD+  +A++++F+++T + W  +    +     
Sbjct: 310 NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF 369

Query: 372 IYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKF 418
              I+F+L+I +GSF+++NL L V+   + E  Q  +  +  +  +F
Sbjct: 370 YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  108 bits (270), Expect = 5e-23
 Identities = 81/351 (23%), Positives = 151/351 (43%), Gaps = 67/351 (19%)

Query: 111  WLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCV--CMTRTDL-PEKIE--------YV 159
            ++F P +  R    ++  H  F   + V I +NC+   M R  + P   E        Y+
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 160  FTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG------ 213
            FT ++  E  +K++A G+C  E  YLR  WN LD  ++ ++ +   + +   SG      
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 214  ---LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKG 270
               LR  R LR L+ +S   GLK++V  L+ S+K + ++ ++      +F ++G+QLFKG
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 271  NLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSD 330
                                                  +C  G D+ +  +   C + S 
Sbjct: 1437 KF-----------------------------------FVC-QGEDTRNITNKSDCAEASY 1460

Query: 331  NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFVLV 380
                +  +FD+   A +SLF L ++D W  +           QQ +       +++F+  
Sbjct: 1461 RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISF 1520

Query: 381  IFLGSFYLVNLILAVVTMAYEEQNQ-ATTDEIEAKEKKFQEALEMLRKEQE 430
            + + +F+++N+ + VV   + +  Q    +E   +E+K    LE  R+ +E
Sbjct: 1521 LLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKE 1571



 Score =  103 bits (257), Expect = 2e-21
 Identities = 78/301 (25%), Positives = 144/301 (47%), Gaps = 36/301 (11%)

Query: 622  EELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIF 681
            +E + +E +C P  +  S             + + ++  L T  + +L IT  I +N + 
Sbjct: 1570 KEKQMAEAQCKPYYSDYS-------------RFRLLVHHLCTSHYLDLFITGVIGLNVVT 1616

Query: 682  MAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSL 741
            MAMEH+      +  L+I N +FT+ F  E VFK++AF    +FQ +WN  D  IV +S+
Sbjct: 1617 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1676

Query: 742  LELGVAK----------KGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT 791
            + + + +             + ++R  R+ RV KL K    +  L+  +  ++  +GNL 
Sbjct: 1677 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1736

Query: 792  IILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHDFFHSFLIVFRILCGE- 849
            ++  ++ F+FA +G +L G+   +     + P E   R     +F  +FL +FR+  G+ 
Sbjct: 1737 LLFMLLFFIFAALGVELFGDLECDE----THPCEGLGRHATFRNFGMAFLTLFRVSTGDN 1792

Query: 850  WIENMWACM-EVGQKSICL------ILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPE 902
            W   M   + +  Q+S C       I F++ ++    V++N+ IA+L+      N  A E
Sbjct: 1793 WNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1852

Query: 903  D 903
            +
Sbjct: 1853 E 1853



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 118/508 (23%), Positives = 200/508 (39%), Gaps = 146/508 (28%)

Query: 113  FSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTD------LPEKIE---YVFTVI 163
            +S ++  R     +    +  LFIT  I +N V M          L E ++   Y+FTVI
Sbjct: 1583 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1642

Query: 164  YTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---------- 213
            +  E++ K++A GF      + +D WN LD +++ L+ +G  ++   ++           
Sbjct: 1643 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1698

Query: 214  -LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
             +R  R+ R LK + +  G++ ++  ++ ++ ++ ++ +L +    +FA +G++LF    
Sbjct: 1699 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF---- 1754

Query: 273  KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332
                   D+  +ET                               H  +G          
Sbjct: 1755 ------GDLECDET-------------------------------HPCEGL--------- 1768

Query: 333  DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK--------IYMIFFVLVIFLG 384
               + +F +F  AFL+LFR+ T D+W  + + TLR   +        I  I+FV  +   
Sbjct: 1769 -GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1827

Query: 385  SFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHS 444
             F LVN+++AV+    EE N+      EAKE            E E+ A L ++  +L  
Sbjct: 1828 QFVLVNVVIAVLMKHLEESNK------EAKE------------EAELEAELELEMKTLSP 1869

Query: 445  HNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSV 504
               SPL S         + P V    + D+  P +          L  A+  R ASH S+
Sbjct: 1870 QPHSPLGSP-------FLWPGVEGPDSPDSPKPGA----------LHPAAHARSASHFSL 1912

Query: 505  FHFRSPGRDISLPEGVTDDGVFPGDHESHRGSL--------LLGGGAGQQGPLPRSPLPQ 556
             H              TD  +F       +GSL         L G  GQ    P +P   
Sbjct: 1913 EH-------------PTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLG 1959

Query: 557  PSNPDSRHGEDEHQPPPTSELAPGAVDV 584
             S+P       + QP PT    P  + V
Sbjct: 1960 GSDP-------QMQPHPTELPGPDLLTV 1980



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 68/282 (24%), Positives = 131/282 (46%), Gaps = 45/282 (15%)

Query: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
            T  +IV+  +F   I+  IL+++ S+  E  Y +Q   +   LE ++ VFT +F  EMLL
Sbjct: 735  TFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLL 792

Query: 1204 KWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSR 1263
            K + YG   Y  N +   D +IV IS+  +  +     +   +  LRT R +R L+ +  
Sbjct: 793  KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRF 847

Query: 1264 FEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPL 1323
               ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF    +  DG+      
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGD------ 898

Query: 1324 SIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVN 1383
            ++ + K                   NFD++    + + Q+ T + W  ++Y  + S    
Sbjct: 899  TLPDRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS---- 935

Query: 1384 MQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQK 1425
                   + +  LYF+  + FG +   NL V ++++ F  ++
Sbjct: 936  ------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 65/271 (23%), Positives = 119/271 (43%), Gaps = 35/271 (12%)

Query: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531
            IV  + F   IM+ I +N ++M +E  +Q EE T  L   N  F ++F  E ++K+    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590
             + Y  N +N+FD ++VV+S+  ++                  V+R  R+ R+L+L+R  
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQ----------QGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SSFPHVRWEAGIDDMFNFQT 1646
              ++  L  LM ++  +    +LL L +FI+SI GM      F   R    + D  NF +
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1647 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYI 1706
               +++ +FQI T   W+ +L                      G   + +   ++F   +
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALM 948

Query: 1707 IISFLIMVNMYIAVILENFNVATEESTEPLS 1737
                 ++ N+ +A+++E F        E  S
Sbjct: 949  TFGNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 49/157 (31%), Positives = 79/157 (50%), Gaps = 17/157 (10%)

Query: 1478 FDITIMVLICLNMITMMV----ETDDQSEEKTKILGKINQFFVAVFTGECVMKMFAL--- 1530
            F+   M++I LN +T+ +    E      ++ +IL   + F  A F  E V+KM AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1531 -RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589
             ++ Y  + WN  DF +V+  +  L +S  L+++        F  +R  R+ R LR I  
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGM--LEYSLDLQNVS-------FSAVRTVRVLRPLRAINR 193

Query: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626
               +R L+  L+ +LP L N+ LL F V FI+ I G+
Sbjct: 194  VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 58/209 (27%), Positives = 93/209 (44%), Gaps = 16/209 (7%)

Query: 626 ESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAM- 684
           E+E    P L  +   YL  D  P    L+T     V +P+ E    L I++N + + M 
Sbjct: 47  EAEGLPYPALAPVVFFYLSQDSRPRSWCLRT-----VCNPWFERISMLVILLNCVTLGMF 101

Query: 685 ---EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA---FDPYYYFQKKWNIFDCIIVT 738
              E          +LQ  +     FF  EMV K++A   F    Y    WN  D  IV 
Sbjct: 102 RPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI 161

Query: 739 VSLLELGVAKKG-SLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
             +LE  +  +  S S +R+ R+LR  +     P++  L+ ++ +++  LGN+ ++   +
Sbjct: 162 AGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 221

Query: 798 VFVFALVGKQLLGENYRNN---RKNISAP 823
            F+F +VG QL     RN     +N S P
Sbjct: 222 FFIFGIVGVQLWAGLLRNRCFLPENFSLP 250


>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
            isoform 9 [Homo sapiens]
          Length = 2273

 Score =  426 bits (1095), Expect = e-118
 Identities = 324/1150 (28%), Positives = 551/1150 (47%), Gaps = 132/1150 (11%)

Query: 671  ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWN 730
            I + I+VNT+ M +E+H         L+I NIVFT  F  EM+ K++ + P+ Y +  +N
Sbjct: 749  IMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808

Query: 731  IFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 790
            IFD +IV +S+ E+   + G LSVLR+FRL+RV KL +  P L   + ++  ++  +   
Sbjct: 809  IFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868

Query: 791  TIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGE- 849
             ++L + +F+F+++G  L G  + + R   + P     R +      + + VF+IL  E 
Sbjct: 869  CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPD----RKNFDSLLWAIVTVFQILTQED 924

Query: 850  WIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPED-DGEVN 908
            W + ++  M     S   + F+ +M  GN V+ NL +A+L+  F A+ ++  ED  G+++
Sbjct: 925  WNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLS 983

Query: 909  NLQVALARIQVFGHRTKQALCSFFSRSC------------------PFPQPKAEPELVV- 949
             +Q+ +   Q       ++   FFS S                   P  +    P L++ 
Sbjct: 984  CIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1042

Query: 950  ------KLPLSSSKAENHIAANTARGSSGGLQAPRGPRDE-----------HSDFIANPT 992
                   LP S+S          +R +S    A  G   E           HS + A  +
Sbjct: 1043 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102

Query: 993  VWVSVPIAE---GESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCG----DHLTP 1045
             W S   +    G +         GE       E      +E+  + ER      DH   
Sbjct: 1103 -WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHR 1161

Query: 1046 RS-PGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTV---DCLDPEEILRKI 1101
             S      SS DL  +L          QVP  G+  T+S  GS     DC       R  
Sbjct: 1162 GSLEREAKSSFDLPDTL----------QVP--GLHRTASGRGSASEHQDCNGKSASGRLA 1209

Query: 1102 PELADDLE--EPDDCFTEGCIR-----------HCPCCKLDTTKSPWDV-----GWQVRK 1143
              L  D    + DD   EG +              P C L+  +  W         + R 
Sbjct: 1210 RALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLE--RDSWSAYIFPPQSRFRL 1267

Query: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
             C+RI+ H  F+  ++ +I L+  ++A E   +D     +  L  ++ +FT +F+ EM +
Sbjct: 1268 LCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTV 1327

Query: 1204 KWVAYGF----KKYFTNAWCWLDFLIVNISLISLTAKILEYSE---VAPIKALRTLRALR 1256
            K VA G+    + Y  ++W  LD L+V IS+I +   ++  S    +  ++ LR LR LR
Sbjct: 1328 KVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLR 1387

Query: 1257 PLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDG 1316
            PLR +SR +G+++VV+ L+ ++  I N++++C  F++IF I+GV LF GKF+ C     G
Sbjct: 1388 PLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QG 1443

Query: 1317 EFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAA 1376
            E +      + NKSDC    +  S+ WV  K NFDN+    ++L  +A+  GW+DIMY  
Sbjct: 1444 EDT----RNITNKSDC----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDG 1495

Query: 1377 VDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMT 1436
            +D+  V+ QP    N +M LYF+ F++   FF LN+FVGV+++NF++ ++    ++    
Sbjct: 1496 LDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RR 1554

Query: 1437 EEQKKYYNAMKKLGSKKPQ------KPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNM 1490
             E+K+     KK  SK+ Q      KP     ++F+  V  + T    D+ I  +I LN+
Sbjct: 1555 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNV 1614

Query: 1491 ITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVVL 1549
            +TM +E   Q +   + L   N  F  +F  E V K+ A   + +F + WN  D  +V+L
Sbjct: 1615 VTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLL 1674

Query: 1550 SIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFN 1609
            SI  +    I  +     +PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N
Sbjct: 1675 SIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1734

Query: 1610 IGLLLFLVMFIYSIFGMSSFPHVRWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWD 1664
            +GLL  L+ FI++  G+  F  +  +      G+     F+ F  + L LF+++T   W+
Sbjct: 1735 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWN 1794

Query: 1665 GLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILEN 1724
            G++   L      CD            C +  +  I+F ++++ +  ++VN+ IAV++++
Sbjct: 1795 GIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKH 1842

Query: 1725 FNVATEESTE 1734
               + +E+ E
Sbjct: 1843 LEESNKEAKE 1852



 Score =  128 bits (321), Expect = 6e-29
 Identities = 112/380 (29%), Positives = 171/380 (45%), Gaps = 95/380 (25%)

Query: 1142 RKTCYRIVEHSWFESFIIFMILLSSGSLAF----EDYYLDQKPTVKALLEYTDRVFTFIF 1197
            R  C R V + WFE   + +ILL+  +L      ED   D +   + L  + D +F F F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFAF-F 128

Query: 1198 VFEMLLKWVA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIKALRT 1251
              EM++K VA   +G K Y  + W  LDF IV        A +LEYS   +     A+RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RC 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    RC
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241

Query: 1311 INYTDGEFSLVPLSI----------------------VNNKSDCK--------------- 1333
              +    FSL PLS+                       N    C+               
Sbjct: 242  --FLPENFSL-PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPC 298

Query: 1334 -----IQNSTGSFFWVNVKVNFDNVAMG-----------------YLALLQVATFKGWMD 1371
                   NS+ +   VN    + N + G                 ++A+ QV T +GW+D
Sbjct: 299  GLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 1372 IMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ 1431
            IMY  +D+           + Y ++YF++ II G FF +NL + VI   F++ K++   +
Sbjct: 359  IMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---E 405

Query: 1432 DIFMTEEQKKYYNAMKKLGS 1451
               M E++ ++ +    L S
Sbjct: 406  SQLMREQRVRFLSNASTLAS 425



 Score =  124 bits (311), Expect = 9e-28
 Identities = 186/899 (20%), Positives = 344/899 (38%), Gaps = 191/899 (21%)

Query: 105  SATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCM---------TRTDLPEK 155
            S+  A W      LI  T  K+    +F   I + ILVN + M           T+  E 
Sbjct: 723  SSVLAFW-----RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEI 777

Query: 156  IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG--ISG 213
               VFT ++  E L+K+L  G     F Y+++P+N  D  VI +  V   +  +G  +S 
Sbjct: 778  SNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSV 832

Query: 214  LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLK 273
            LRTFR++R LK V  +P L+  +  L+ ++  +A   +L +  + +F+++G+ LF     
Sbjct: 833  LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---- 888

Query: 274  NKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPD 333
                           ++S R  D   +++                               
Sbjct: 889  -------------CKFASERDGDTLPDRK------------------------------- 904

Query: 334  FNYTSFDSFAWAFLSLFRLMTQDSWER--------------LYQQTLRTSGKIYMIFFVL 379
                +FDS  WA +++F+++TQ+ W +              LY   L T G   +   ++
Sbjct: 905  ----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 380  VIFLGSFYLVNLI--------LAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEV 431
             I +  F    +         L+ + +  + Q     ++ E++   F  +L+     ++ 
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQG-GDANKSESEPDFFSPSLDGDGDRKKC 1019

Query: 432  LAALGI-DTTSLHSHNGSPLTSKNAS--------------------ERRHRIKPRVSEGS 470
            LA + + +   L      PL    A+                     RR         G+
Sbjct: 1020 LALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGA 1079

Query: 471  TEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDH 530
              + KSP S   +         +   RR+S  S+   R+P      P G           
Sbjct: 1080 AHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLG--RAPSLKRRSPSG----------- 1126

Query: 531  ESHRGSLLLGGGAGQQGPLPRSPLPQ--PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFD 588
               R SLL G G   Q     S   +  P+  D RH     +   +S   P  + V    
Sbjct: 1127 --ERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLH 1184

Query: 589  AGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIW--- 645
                    ++E+ D     + A   ++      +   + +        S  ++   W   
Sbjct: 1185 RTASGRGSASEHQD--CNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRA 1242

Query: 646  ---DCC-----------PMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP 691
                CC           P   + + +   ++T    +  + + I +N I +AME   + P
Sbjct: 1243 RLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDP 1302

Query: 692  --TFEAMLQIGNIVFTIFFTAEMVFKIIA----FDPYYYFQKKWNIFDCIIVTVSLLEL- 744
                   L + N +FT  F AEM  K++A    F    Y +  WN+ D ++V +S++++ 
Sbjct: 1303 HSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDIL 1362

Query: 745  -------GVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
                   G    G L VLR  R LR  ++      L  +++ + +S+  +GN+ +I    
Sbjct: 1363 VSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAF 1422

Query: 798  VFVFALVGKQLL--------GENYRN--NRKNISAPHEDWPRWHMHDF--FHSFLIVFRI 845
              +F ++G QL         GE+ RN  N+ + +     W R H ++F      L+   +
Sbjct: 1423 FIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVR-HKYNFDNLGQALMSLFV 1481

Query: 846  LCGE--WIENMWACME---VGQKSI------CLILFLTVMVLGNLVVLNLFIALLLNSF 893
            L  +  W++ M+  ++   V Q+ I       L+ F++ +++    VLN+F+ +++ +F
Sbjct: 1482 LASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  118 bits (296), Expect = 5e-26
 Identities = 82/347 (23%), Positives = 158/347 (45%), Gaps = 49/347 (14%)

Query: 120 RRTAIKVSVHSWFSLFITVTILVNCVCM-------------TRTDLPEKIEYVFTVIYTF 166
           R   ++   + WF     + IL+NCV +              R  + +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGIS--GLRTFRVLRALK 224
           E ++K++A G    +  YL D WN LDF ++    +  ++DL+ +S   +RT RVLR L+
Sbjct: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKND---- 280
            ++ +P ++++V  L+ ++  L +V +L  F   +F +VG+QL+ G L+N+C   +    
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 281 -MAVNETTNYSSHRK---PDIYINKRGT------SDPLLCGNGSDSGHCPDGYICLKTSD 330
            ++V+    Y +  +   P I    R        S P L G+G     C   Y    +S 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS 309

Query: 331 -------------------NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK 371
                              NP     +FD+  +A++++F+++T + W  +    +     
Sbjct: 310 NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF 369

Query: 372 IYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKF 418
              I+F+L+I +GSF+++NL L V+   + E  Q  +  +  +  +F
Sbjct: 370 YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  108 bits (270), Expect = 5e-23
 Identities = 81/351 (23%), Positives = 151/351 (43%), Gaps = 67/351 (19%)

Query: 111  WLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCV--CMTRTDL-PEKIE--------YV 159
            ++F P +  R    ++  H  F   + V I +NC+   M R  + P   E        Y+
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 160  FTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG------ 213
            FT ++  E  +K++A G+C  E  YLR  WN LD  ++ ++ +   + +   SG      
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 214  ---LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKG 270
               LR  R LR L+ +S   GLK++V  L+ S+K + ++ ++      +F ++G+QLFKG
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 271  NLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSD 330
                                                  +C  G D+ +  +   C + S 
Sbjct: 1437 KF-----------------------------------FVC-QGEDTRNITNKSDCAEASY 1460

Query: 331  NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFVLV 380
                +  +FD+   A +SLF L ++D W  +           QQ +       +++F+  
Sbjct: 1461 RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISF 1520

Query: 381  IFLGSFYLVNLILAVVTMAYEEQNQ-ATTDEIEAKEKKFQEALEMLRKEQE 430
            + + +F+++N+ + VV   + +  Q    +E   +E+K    LE  R+ +E
Sbjct: 1521 LLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKE 1571



 Score =  103 bits (257), Expect = 2e-21
 Identities = 78/301 (25%), Positives = 144/301 (47%), Gaps = 36/301 (11%)

Query: 622  EELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIF 681
            +E + +E +C P  +  S             + + ++  L T  + +L IT  I +N + 
Sbjct: 1570 KEKQMAEAQCKPYYSDYS-------------RFRLLVHHLCTSHYLDLFITGVIGLNVVT 1616

Query: 682  MAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSL 741
            MAMEH+      +  L+I N +FT+ F  E VFK++AF    +FQ +WN  D  IV +S+
Sbjct: 1617 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1676

Query: 742  LELGVAK----------KGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT 791
            + + + +             + ++R  R+ RV KL K    +  L+  +  ++  +GNL 
Sbjct: 1677 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1736

Query: 792  IILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHDFFHSFLIVFRILCGE- 849
            ++  ++ F+FA +G +L G+   +     + P E   R     +F  +FL +FR+  G+ 
Sbjct: 1737 LLFMLLFFIFAALGVELFGDLECDE----THPCEGLGRHATFRNFGMAFLTLFRVSTGDN 1792

Query: 850  WIENMWACM-EVGQKSICL------ILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPE 902
            W   M   + +  Q+S C       I F++ ++    V++N+ IA+L+      N  A E
Sbjct: 1793 WNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1852

Query: 903  D 903
            +
Sbjct: 1853 E 1853



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 109/472 (23%), Positives = 188/472 (39%), Gaps = 127/472 (26%)

Query: 113  FSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTD------LPEKIE---YVFTVI 163
            +S ++  R     +    +  LFIT  I +N V M          L E ++   Y+FTVI
Sbjct: 1583 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1642

Query: 164  YTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---------- 213
            +  E++ K++A GF      + +D WN LD +++ L+ +G  ++   ++           
Sbjct: 1643 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1698

Query: 214  -LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
             +R  R+ R LK + +  G++ ++  ++ ++ ++ ++ +L +    +FA +G++LF    
Sbjct: 1699 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF---- 1754

Query: 273  KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332
                   D+  +ET                               H  +G          
Sbjct: 1755 ------GDLECDET-------------------------------HPCEGL--------- 1768

Query: 333  DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK--------IYMIFFVLVIFLG 384
               + +F +F  AFL+LFR+ T D+W  + + TLR   +        I  I+FV  +   
Sbjct: 1769 -GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1827

Query: 385  SFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHS 444
             F LVN+++AV+    EE N+      EAKE            E E+ A L ++  +L  
Sbjct: 1828 QFVLVNVVIAVLMKHLEESNK------EAKE------------EAELEAELELEMKTLSP 1869

Query: 445  HNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSV 504
               SPL S         + P V    + D+  P +          L  A+  R ASH S+
Sbjct: 1870 QPHSPLGSP-------FLWPGVEGPDSPDSPKPGA----------LHPAAHARSASHFSL 1912

Query: 505  FH-------FRSPGRDISL--PEGVTDDGVFPGDHESHRGSLLLGGGAGQQG 547
             H          PG D+      GV+     P D    R      G  G +G
Sbjct: 1913 EHPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRG 1964



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 68/282 (24%), Positives = 131/282 (46%), Gaps = 45/282 (15%)

Query: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
            T  +IV+  +F   I+  IL+++ S+  E  Y +Q   +   LE ++ VFT +F  EMLL
Sbjct: 735  TFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLL 792

Query: 1204 KWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSR 1263
            K + YG   Y  N +   D +IV IS+  +  +     +   +  LRT R +R L+ +  
Sbjct: 793  KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRF 847

Query: 1264 FEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPL 1323
               ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF    +  DG+      
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGD------ 898

Query: 1324 SIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVN 1383
            ++ + K                   NFD++    + + Q+ T + W  ++Y  + S    
Sbjct: 899  TLPDRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS---- 935

Query: 1384 MQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQK 1425
                   + +  LYF+  + FG +   NL V ++++ F  ++
Sbjct: 936  ------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 65/271 (23%), Positives = 119/271 (43%), Gaps = 35/271 (12%)

Query: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531
            IV  + F   IM+ I +N ++M +E  +Q EE T  L   N  F ++F  E ++K+    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590
             + Y  N +N+FD ++VV+S+  ++                  V+R  R+ R+L+L+R  
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQ----------QGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SSFPHVRWEAGIDDMFNFQT 1646
              ++  L  LM ++  +    +LL L +FI+SI GM      F   R    + D  NF +
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1647 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYI 1706
               +++ +FQI T   W+ +L                      G   + +   ++F   +
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALM 948

Query: 1707 IISFLIMVNMYIAVILENFNVATEESTEPLS 1737
                 ++ N+ +A+++E F        E  S
Sbjct: 949  TFGNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 49/157 (31%), Positives = 79/157 (50%), Gaps = 17/157 (10%)

Query: 1478 FDITIMVLICLNMITMMV----ETDDQSEEKTKILGKINQFFVAVFTGECVMKMFAL--- 1530
            F+   M++I LN +T+ +    E      ++ +IL   + F  A F  E V+KM AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1531 -RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589
             ++ Y  + WN  DF +V+  +  L +S  L+++        F  +R  R+ R LR I  
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGM--LEYSLDLQNVS-------FSAVRTVRVLRPLRAINR 193

Query: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626
               +R L+  L+ +LP L N+ LL F V FI+ I G+
Sbjct: 194  VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 58/209 (27%), Positives = 93/209 (44%), Gaps = 16/209 (7%)

Query: 626 ESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAM- 684
           E+E    P L  +   YL  D  P    L+T     V +P+ E    L I++N + + M 
Sbjct: 47  EAEGLPYPALAPVVFFYLSQDSRPRSWCLRT-----VCNPWFERISMLVILLNCVTLGMF 101

Query: 685 ---EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA---FDPYYYFQKKWNIFDCIIVT 738
              E          +LQ  +     FF  EMV K++A   F    Y    WN  D  IV 
Sbjct: 102 RPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI 161

Query: 739 VSLLELGVAKKG-SLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
             +LE  +  +  S S +R+ R+LR  +     P++  L+ ++ +++  LGN+ ++   +
Sbjct: 162 AGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 221

Query: 798 VFVFALVGKQLLGENYRNN---RKNISAP 823
            F+F +VG QL     RN     +N S P
Sbjct: 222 FFIFGIVGVQLWAGLLRNRCFLPENFSLP 250


>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
            isoform 10 [Homo sapiens]
          Length = 2266

 Score =  426 bits (1094), Expect = e-118
 Identities = 322/1144 (28%), Positives = 548/1144 (47%), Gaps = 127/1144 (11%)

Query: 671  ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWN 730
            I + I+VNT+ M +E+H         L+I NIVFT  F  EM+ K++ + P+ Y +  +N
Sbjct: 749  IMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808

Query: 731  IFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 790
            IFD +IV +S+ E+   + G LSVLR+FRL+RV KL +  P L   + ++  ++  +   
Sbjct: 809  IFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868

Query: 791  TIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGE- 849
             ++L + +F+F+++G  L G  + + R   + P     R +      + + VF+IL  E 
Sbjct: 869  CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPD----RKNFDSLLWAIVTVFQILTQED 924

Query: 850  WIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPED-DGEVN 908
            W + ++  M     S   + F+ +M  GN V+ NL +A+L+  F A+ ++  ED  G+++
Sbjct: 925  WNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLS 983

Query: 909  NLQVALARIQVFGHRTKQALCSFFSRSC------------------PFPQPKAEPELVV- 949
             +Q+ +   Q       ++   FFS S                   P  +    P L++ 
Sbjct: 984  CIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1042

Query: 950  ------KLPLSSSKAENHIAANTARGSSGGLQAPRGPRDE-----------HSDFIANPT 992
                   LP S+S          +R +S    A  G   E           HS + A  +
Sbjct: 1043 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102

Query: 993  VWVSVPIAE---GESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCG----DHLTP 1045
             W S   +    G +         GE       E      +E+  + ER      DH   
Sbjct: 1103 -WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHR 1161

Query: 1046 RS-PGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTV---DCLDPEEILRKI 1101
             S      SS DL  +L          QVP  G+  T+S  GS     DC       R  
Sbjct: 1162 GSLEREAKSSFDLPDTL----------QVP--GLHRTASGRGSASEHQDCNGKSASGRLA 1209

Query: 1102 PELADDLE--EPDDCFTEGCIR-----------HCPCCKLDTTKSPWDV-----GWQVRK 1143
              L  D    + DD   EG +              P C L+  +  W         + R 
Sbjct: 1210 RALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLE--RDSWSAYIFPPQSRFRL 1267

Query: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
             C+RI+ H  F+  ++ +I L+  ++A E   +D     +  L  ++ +FT +F+ EM +
Sbjct: 1268 LCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTV 1327

Query: 1204 KWVAYGF----KKYFTNAWCWLDFLIVNISLISLTAKILEYSE---VAPIKALRTLRALR 1256
            K VA G+    + Y  ++W  LD L+V IS+I +   ++  S    +  ++ LR LR LR
Sbjct: 1328 KVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLR 1387

Query: 1257 PLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDG 1316
            PLR +SR +G+++VV+ L+ ++  I N++++C  F++IF I+GV LF GKF+ C     G
Sbjct: 1388 PLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QG 1443

Query: 1317 EFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAA 1376
            E +      + NKSDC    +  S+ WV  K NFDN+    ++L  +A+  GW+DIMY  
Sbjct: 1444 EDT----RNITNKSDC----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDG 1495

Query: 1377 VDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMT 1436
            +D+  V+ QP    N +M LYF+ F++   FF LN+FVGV+++NF++ ++    ++    
Sbjct: 1496 LDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRR 1555

Query: 1437 EEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVE 1496
            EE  K    ++K   K   KP     ++F+  V  + T    D+ I  +I LN++TM +E
Sbjct: 1556 EE--KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1613

Query: 1497 TDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVVLSIASLI 1555
               Q +   + L   N  F  +F  E V K+ A   + +F + WN  D  +V+LSI  + 
Sbjct: 1614 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1673

Query: 1556 FSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLF 1615
               I  +     +PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  
Sbjct: 1674 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1733

Query: 1616 LVMFIYSIFGMSSFPHVRWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1670
            L+ FI++  G+  F  +  +      G+     F+ F  + L LF+++T   W+G++   
Sbjct: 1734 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1793

Query: 1671 LNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATE 1730
            L      CD            C +  +  I+F ++++ +  ++VN+ IAV++++   + +
Sbjct: 1794 LRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1841

Query: 1731 ESTE 1734
            E+ E
Sbjct: 1842 EAKE 1845



 Score =  128 bits (321), Expect = 6e-29
 Identities = 112/380 (29%), Positives = 171/380 (45%), Gaps = 95/380 (25%)

Query: 1142 RKTCYRIVEHSWFESFIIFMILLSSGSLAF----EDYYLDQKPTVKALLEYTDRVFTFIF 1197
            R  C R V + WFE   + +ILL+  +L      ED   D +   + L  + D +F F F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFAF-F 128

Query: 1198 VFEMLLKWVA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIKALRT 1251
              EM++K VA   +G K Y  + W  LDF IV        A +LEYS   +     A+RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RC 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    RC
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241

Query: 1311 INYTDGEFSLVPLSI----------------------VNNKSDCK--------------- 1333
              +    FSL PLS+                       N    C+               
Sbjct: 242  --FLPENFSL-PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPC 298

Query: 1334 -----IQNSTGSFFWVNVKVNFDNVAMG-----------------YLALLQVATFKGWMD 1371
                   NS+ +   VN    + N + G                 ++A+ QV T +GW+D
Sbjct: 299  GLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 1372 IMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ 1431
            IMY  +D+           + Y ++YF++ II G FF +NL + VI   F++ K++   +
Sbjct: 359  IMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---E 405

Query: 1432 DIFMTEEQKKYYNAMKKLGS 1451
               M E++ ++ +    L S
Sbjct: 406  SQLMREQRVRFLSNASTLAS 425



 Score =  124 bits (311), Expect = 9e-28
 Identities = 186/899 (20%), Positives = 344/899 (38%), Gaps = 191/899 (21%)

Query: 105  SATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCM---------TRTDLPEK 155
            S+  A W      LI  T  K+    +F   I + ILVN + M           T+  E 
Sbjct: 723  SSVLAFW-----RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEI 777

Query: 156  IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG--ISG 213
               VFT ++  E L+K+L  G     F Y+++P+N  D  VI +  V   +  +G  +S 
Sbjct: 778  SNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSV 832

Query: 214  LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLK 273
            LRTFR++R LK V  +P L+  +  L+ ++  +A   +L +  + +F+++G+ LF     
Sbjct: 833  LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---- 888

Query: 274  NKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPD 333
                           ++S R  D   +++                               
Sbjct: 889  -------------CKFASERDGDTLPDRK------------------------------- 904

Query: 334  FNYTSFDSFAWAFLSLFRLMTQDSWER--------------LYQQTLRTSGKIYMIFFVL 379
                +FDS  WA +++F+++TQ+ W +              LY   L T G   +   ++
Sbjct: 905  ----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 380  VIFLGSFYLVNLI--------LAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEV 431
             I +  F    +         L+ + +  + Q     ++ E++   F  +L+     ++ 
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQG-GDANKSESEPDFFSPSLDGDGDRKKC 1019

Query: 432  LAALGI-DTTSLHSHNGSPLTSKNAS--------------------ERRHRIKPRVSEGS 470
            LA + + +   L      PL    A+                     RR         G+
Sbjct: 1020 LALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGA 1079

Query: 471  TEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDH 530
              + KSP S   +         +   RR+S  S+   R+P      P G           
Sbjct: 1080 AHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLG--RAPSLKRRSPSG----------- 1126

Query: 531  ESHRGSLLLGGGAGQQGPLPRSPLPQ--PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFD 588
               R SLL G G   Q     S   +  P+  D RH     +   +S   P  + V    
Sbjct: 1127 --ERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLH 1184

Query: 589  AGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIW--- 645
                    ++E+ D     + A   ++      +   + +        S  ++   W   
Sbjct: 1185 RTASGRGSASEHQD--CNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRA 1242

Query: 646  ---DCC-----------PMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP 691
                CC           P   + + +   ++T    +  + + I +N I +AME   + P
Sbjct: 1243 RLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDP 1302

Query: 692  --TFEAMLQIGNIVFTIFFTAEMVFKIIA----FDPYYYFQKKWNIFDCIIVTVSLLEL- 744
                   L + N +FT  F AEM  K++A    F    Y +  WN+ D ++V +S++++ 
Sbjct: 1303 HSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDIL 1362

Query: 745  -------GVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
                   G    G L VLR  R LR  ++      L  +++ + +S+  +GN+ +I    
Sbjct: 1363 VSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAF 1422

Query: 798  VFVFALVGKQLL--------GENYRN--NRKNISAPHEDWPRWHMHDF--FHSFLIVFRI 845
              +F ++G QL         GE+ RN  N+ + +     W R H ++F      L+   +
Sbjct: 1423 FIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVR-HKYNFDNLGQALMSLFV 1481

Query: 846  LCGE--WIENMWACME---VGQKSI------CLILFLTVMVLGNLVVLNLFIALLLNSF 893
            L  +  W++ M+  ++   V Q+ I       L+ F++ +++    VLN+F+ +++ +F
Sbjct: 1482 LASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  118 bits (296), Expect = 5e-26
 Identities = 82/347 (23%), Positives = 158/347 (45%), Gaps = 49/347 (14%)

Query: 120 RRTAIKVSVHSWFSLFITVTILVNCVCM-------------TRTDLPEKIEYVFTVIYTF 166
           R   ++   + WF     + IL+NCV +              R  + +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGIS--GLRTFRVLRALK 224
           E ++K++A G    +  YL D WN LDF ++    +  ++DL+ +S   +RT RVLR L+
Sbjct: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKND---- 280
            ++ +P ++++V  L+ ++  L +V +L  F   +F +VG+QL+ G L+N+C   +    
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 281 -MAVNETTNYSSHRK---PDIYINKRGT------SDPLLCGNGSDSGHCPDGYICLKTSD 330
            ++V+    Y +  +   P I    R        S P L G+G     C   Y    +S 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS 309

Query: 331 -------------------NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK 371
                              NP     +FD+  +A++++F+++T + W  +    +     
Sbjct: 310 NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF 369

Query: 372 IYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKF 418
              I+F+L+I +GSF+++NL L V+   + E  Q  +  +  +  +F
Sbjct: 370 YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  107 bits (266), Expect = 1e-22
 Identities = 80/351 (22%), Positives = 151/351 (43%), Gaps = 68/351 (19%)

Query: 111  WLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCV--CMTRTDL-PEKIE--------YV 159
            ++F P +  R    ++  H  F   + V I +NC+   M R  + P   E        Y+
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 160  FTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG------ 213
            FT ++  E  +K++A G+C  E  YLR  WN LD  ++ ++ +   + +   SG      
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 214  ---LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKG 270
               LR  R LR L+ +S   GLK++V  L+ S+K + ++ ++      +F ++G+QLFKG
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 271  NLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSD 330
                                                  +C  G D+ +  +   C + S 
Sbjct: 1437 KF-----------------------------------FVC-QGEDTRNITNKSDCAEASY 1460

Query: 331  NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFVLV 380
                +  +FD+   A +SLF L ++D W  +           QQ +       +++F+  
Sbjct: 1461 RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISF 1520

Query: 381  IFLGSFYLVNLILAVVTMAYEE--QNQATTDEIEAKEKKFQEALEMLRKEQ 429
            + + +F+++N+ + VV   + +  Q+Q   +    +EK+ +   +  RK Q
Sbjct: 1521 LLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRKAQ 1571



 Score =  106 bits (264), Expect = 3e-22
 Identities = 81/304 (26%), Positives = 148/304 (48%), Gaps = 26/304 (8%)

Query: 622  EELEESEQKCPPCLTSLSQKYLIWDCCPMWV---KLKTILFGLVTDPFAELTITLCIVVN 678
            +E EE+ ++    L  L +K     C P +    + + ++  L T  + +L IT  I +N
Sbjct: 1547 QEEEEARRREEKRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1606

Query: 679  TIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVT 738
             + MAMEH+      +  L+I N +FT+ F  E VFK++AF    +FQ +WN  D  IV 
Sbjct: 1607 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1666

Query: 739  VSLLELGVAK----------KGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 788
            +S++ + + +             + ++R  R+ RV KL K    +  L+  +  ++  +G
Sbjct: 1667 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1726

Query: 789  NLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHDFFHSFLIVFRILC 847
            NL ++  ++ F+FA +G +L G+   +     + P E   R     +F  +FL +FR+  
Sbjct: 1727 NLGLLFMLLFFIFAALGVELFGDLECDE----THPCEGLGRHATFRNFGMAFLTLFRVST 1782

Query: 848  GE-WIENMWACM-EVGQKSICL------ILFLTVMVLGNLVVLNLFIALLLNSFSADNLT 899
            G+ W   M   + +  Q+S C       I F++ ++    V++N+ IA+L+      N  
Sbjct: 1783 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1842

Query: 900  APED 903
            A E+
Sbjct: 1843 AKEE 1846



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 109/472 (23%), Positives = 188/472 (39%), Gaps = 127/472 (26%)

Query: 113  FSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTD------LPEKIE---YVFTVI 163
            +S ++  R     +    +  LFIT  I +N V M          L E ++   Y+FTVI
Sbjct: 1576 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1635

Query: 164  YTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---------- 213
            +  E++ K++A GF      + +D WN LD +++ L+ +G  ++   ++           
Sbjct: 1636 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1691

Query: 214  -LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
             +R  R+ R LK + +  G++ ++  ++ ++ ++ ++ +L +    +FA +G++LF    
Sbjct: 1692 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF---- 1747

Query: 273  KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332
                   D+  +ET                               H  +G          
Sbjct: 1748 ------GDLECDET-------------------------------HPCEGL--------- 1761

Query: 333  DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK--------IYMIFFVLVIFLG 384
               + +F +F  AFL+LFR+ T D+W  + + TLR   +        I  I+FV  +   
Sbjct: 1762 -GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1820

Query: 385  SFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHS 444
             F LVN+++AV+    EE N+      EAKE            E E+ A L ++  +L  
Sbjct: 1821 QFVLVNVVIAVLMKHLEESNK------EAKE------------EAELEAELELEMKTLSP 1862

Query: 445  HNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSV 504
               SPL S         + P V    + D+  P +          L  A+  R ASH S+
Sbjct: 1863 QPHSPLGSP-------FLWPGVEGPDSPDSPKPGA----------LHPAAHARSASHFSL 1905

Query: 505  FH-------FRSPGRDISL--PEGVTDDGVFPGDHESHRGSLLLGGGAGQQG 547
             H          PG D+      GV+     P D    R      G  G +G
Sbjct: 1906 EHPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRG 1957



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 68/282 (24%), Positives = 131/282 (46%), Gaps = 45/282 (15%)

Query: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
            T  +IV+  +F   I+  IL+++ S+  E  Y +Q   +   LE ++ VFT +F  EMLL
Sbjct: 735  TFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLL 792

Query: 1204 KWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSR 1263
            K + YG   Y  N +   D +IV IS+  +  +     +   +  LRT R +R L+ +  
Sbjct: 793  KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRF 847

Query: 1264 FEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPL 1323
               ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF    +  DG+      
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGD------ 898

Query: 1324 SIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVN 1383
            ++ + K                   NFD++    + + Q+ T + W  ++Y  + S    
Sbjct: 899  TLPDRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS---- 935

Query: 1384 MQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQK 1425
                   + +  LYF+  + FG +   NL V ++++ F  ++
Sbjct: 936  ------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 65/271 (23%), Positives = 119/271 (43%), Gaps = 35/271 (12%)

Query: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531
            IV  + F   IM+ I +N ++M +E  +Q EE T  L   N  F ++F  E ++K+    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590
             + Y  N +N+FD ++VV+S+  ++                  V+R  R+ R+L+L+R  
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQ----------QGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SSFPHVRWEAGIDDMFNFQT 1646
              ++  L  LM ++  +    +LL L +FI+SI GM      F   R    + D  NF +
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1647 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYI 1706
               +++ +FQI T   W+ +L                      G   + +   ++F   +
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALM 948

Query: 1707 IISFLIMVNMYIAVILENFNVATEESTEPLS 1737
                 ++ N+ +A+++E F        E  S
Sbjct: 949  TFGNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 49/157 (31%), Positives = 79/157 (50%), Gaps = 17/157 (10%)

Query: 1478 FDITIMVLICLNMITMMV----ETDDQSEEKTKILGKINQFFVAVFTGECVMKMFAL--- 1530
            F+   M++I LN +T+ +    E      ++ +IL   + F  A F  E V+KM AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1531 -RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589
             ++ Y  + WN  DF +V+  +  L +S  L+++        F  +R  R+ R LR I  
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGM--LEYSLDLQNVS-------FSAVRTVRVLRPLRAINR 193

Query: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626
               +R L+  L+ +LP L N+ LL F V FI+ I G+
Sbjct: 194  VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 58/209 (27%), Positives = 93/209 (44%), Gaps = 16/209 (7%)

Query: 626 ESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAM- 684
           E+E    P L  +   YL  D  P    L+T     V +P+ E    L I++N + + M 
Sbjct: 47  EAEGLPYPALAPVVFFYLSQDSRPRSWCLRT-----VCNPWFERISMLVILLNCVTLGMF 101

Query: 685 ---EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA---FDPYYYFQKKWNIFDCIIVT 738
              E          +LQ  +     FF  EMV K++A   F    Y    WN  D  IV 
Sbjct: 102 RPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI 161

Query: 739 VSLLELGVAKKG-SLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
             +LE  +  +  S S +R+ R+LR  +     P++  L+ ++ +++  LGN+ ++   +
Sbjct: 162 AGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 221

Query: 798 VFVFALVGKQLLGENYRNN---RKNISAP 823
            F+F +VG QL     RN     +N S P
Sbjct: 222 FFIFGIVGVQLWAGLLRNRCFLPENFSLP 250


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score =  425 bits (1092), Expect = e-118
 Identities = 317/1128 (28%), Positives = 551/1128 (48%), Gaps = 111/1128 (9%)

Query: 671  ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWN 730
            I + I+VNT+ M +E+H         L+I NIVFT  F  EM+ K++ + P+ Y +  +N
Sbjct: 749  IMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808

Query: 731  IFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 790
            IFD +IV +S+ E+   + G LSVLR+FRL+RV KL +  P L   + ++  ++  +   
Sbjct: 809  IFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868

Query: 791  TIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGE- 849
             ++L + +F+F+++G  L G  + + R   + P     R +      + + VF+IL  E 
Sbjct: 869  CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPD----RKNFDSLLWAIVTVFQILTQED 924

Query: 850  WIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSAD----------NLT 899
            W + ++  M     S   + F+ +M  GN V+ NL +A+L+  F A+          +  
Sbjct: 925  WNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFF 983

Query: 900  APEDDGEVNNLQVALARIQVFGH-RTKQALCS---FFSRSCPFPQPKAEPELVVKLPLSS 955
            +P  DG+  + +  LA + +  H   +++L       + + P   PK+    + +  L  
Sbjct: 984  SPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEA-LGP 1041

Query: 956  SKAENHIAANTARGSSGGLQAPRGPRDE-HSDFIANPTVWVSVPIAE---GESDLDDLED 1011
            +      + +   G++  +++P   R   HS + A  + W S   +    G +       
Sbjct: 1042 ASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS-WTSRRSSRNSLGRAPSLKRRS 1100

Query: 1012 DGGEDAQSFQQEVIPKGQQEQLQQVERCG----DHLTPRS-PGTGTSSEDLAPSLGETWK 1066
              GE       E      +E+  + ER      DH    S      SS DL  +L     
Sbjct: 1101 PSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTL----- 1155

Query: 1067 DESVPQVPAEGVDDTSSSEGSTV---DCLDPEEILRKIPELADDLE--EPDDCFTEGCIR 1121
                 QVP  G+  T+S  GS     DC       R    L  D    + DD   EG + 
Sbjct: 1156 -----QVP--GLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLS 1208

Query: 1122 -----------HCPCCKLDTTKSPWDV-----GWQVRKTCYRIVEHSWFESFIIFMILLS 1165
                         P C L+  +  W         + R  C+RI+ H  F+  ++ +I L+
Sbjct: 1209 KGERVRAWIRARLPACCLE--RDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLN 1266

Query: 1166 SGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGF----KKYFTNAWCWL 1221
              ++A E   +D     +  L  ++ +FT +F+ EM +K VA G+    + Y  ++W  L
Sbjct: 1267 CITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVL 1326

Query: 1222 DFLIVNISLISLTAKILEYSE---VAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAI 1278
            D L+V IS+I +   ++  S    +  ++ LR LR LRPLR +SR +G+++VV+ L+ ++
Sbjct: 1327 DGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSL 1386

Query: 1279 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNST 1338
              I N++++C  F++IF I+GV LF GKF+ C     GE +      + NKSDC    + 
Sbjct: 1387 KPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDT----RNITNKSDC----AE 1434

Query: 1339 GSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYF 1398
             S+ WV  K NFDN+    ++L  +A+  GW+DIMY  +D+  V+ QP    N +M LYF
Sbjct: 1435 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1494

Query: 1399 VIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ--- 1455
            + F++   FF LN+FVGV+++NF++ ++    ++     E+K+     KK  SK+ Q   
Sbjct: 1495 ISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQMAE 1553

Query: 1456 ---KPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKIN 1512
               KP     ++F+  V  + T    D+ I  +I LN++TM +E   Q +   + L   N
Sbjct: 1554 AQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICN 1613

Query: 1513 QFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTL 1571
              F  +F  E V K+ A   + +F + WN  D  +V+LSI  +    I  +     +PT+
Sbjct: 1614 YIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTI 1673

Query: 1572 FRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPH 1631
             R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  F  
Sbjct: 1674 IRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1733

Query: 1632 VRWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSN 1686
            +  +      G+     F+ F  + L LF+++T   W+G++   L      CD       
Sbjct: 1734 LECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD------- 1782

Query: 1687 GTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTE 1734
                 C +  +  I+F ++++ +  ++VN+ IAV++++   + +E+ E
Sbjct: 1783 -QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829



 Score =  149 bits (375), Expect = 3e-35
 Identities = 186/876 (21%), Positives = 350/876 (39%), Gaps = 168/876 (19%)

Query: 105  SATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCM---------TRTDLPEK 155
            S+  A W      LI  T  K+    +F   I + ILVN + M           T+  E 
Sbjct: 723  SSVLAFW-----RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEI 777

Query: 156  IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG--ISG 213
               VFT ++  E L+K+L  G     F Y+++P+N  D  VI +  V   +  +G  +S 
Sbjct: 778  SNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSV 832

Query: 214  LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLK 273
            LRTFR++R LK V  +P L+  +  L+ ++  +A   +L +  + +F+++G+ LF     
Sbjct: 833  LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---- 888

Query: 274  NKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPD 333
                           ++S R  D   +++                               
Sbjct: 889  -------------CKFASERDGDTLPDRK------------------------------- 904

Query: 334  FNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLIL 393
                +FDS  WA +++F+++TQ+ W ++    + ++     ++F+ ++  G++ L NL++
Sbjct: 905  ----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 394  AVVTMAYEEQNQATTDEIEAK----------EKKFQEALEMLRKEQEVLAALGIDTTSLH 443
            A++   ++ +  A   E E            ++K   AL  L +  E+  +L +    +H
Sbjct: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIH 1019

Query: 444  SHNGSPLTSKNAS----------ERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLA 493
            +        K+ S           RR         G+  + KSP S   +         +
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1079

Query: 494  SGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSP 553
               RR+S  S+   R+P      P G              R SLL G G   Q     S 
Sbjct: 1080 WTSRRSSRNSLG--RAPSLKRRSPSG-------------ERRSLLSGEGQESQDEEESSE 1124

Query: 554  LPQ--PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAM 611
              +  P+  D RH     +   +S   P  + V            ++E+ D     + A 
Sbjct: 1125 EERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQD--CNGKSAS 1182

Query: 612  SVVSIITSVLEELEESEQKCPPCLTSLSQKYLIW------DCC-----------PMWVKL 654
              ++      +   + +        S  ++   W       CC           P   + 
Sbjct: 1183 GRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRF 1242

Query: 655  KTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP--TFEAMLQIGNIVFTIFFTAEM 712
            + +   ++T    +  + + I +N I +AME   + P       L + N +FT  F AEM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 713  VFKIIA----FDPYYYFQKKWNIFDCIIVTVSLLEL--------GVAKKGSLSVLRSFRL 760
              K++A    F    Y +  WN+ D ++V +S++++        G    G L VLR  R 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 761  LRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLL--------GEN 812
            LR  ++      L  +++ + +S+  +GN+ +I      +F ++G QL         GE+
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422

Query: 813  YRN--NRKNISAPHEDWPRWHMHDF--FHSFLIVFRILCGE--WIENMWACME---VGQK 863
             RN  N+ + +     W R H ++F      L+   +L  +  W++ M+  ++   V Q+
Sbjct: 1423 TRNITNKSDCAEASYRWVR-HKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQ 1481

Query: 864  SI------CLILFLTVMVLGNLVVLNLFIALLLNSF 893
             I       L+ F++ +++    VLN+F+ +++ +F
Sbjct: 1482 PIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  128 bits (321), Expect = 6e-29
 Identities = 112/380 (29%), Positives = 171/380 (45%), Gaps = 95/380 (25%)

Query: 1142 RKTCYRIVEHSWFESFIIFMILLSSGSLAF----EDYYLDQKPTVKALLEYTDRVFTFIF 1197
            R  C R V + WFE   + +ILL+  +L      ED   D +   + L  + D +F F F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFAF-F 128

Query: 1198 VFEMLLKWVA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIKALRT 1251
              EM++K VA   +G K Y  + W  LDF IV        A +LEYS   +     A+RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RC 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    RC
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241

Query: 1311 INYTDGEFSLVPLSI----------------------VNNKSDCK--------------- 1333
              +    FSL PLS+                       N    C+               
Sbjct: 242  --FLPENFSL-PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPC 298

Query: 1334 -----IQNSTGSFFWVNVKVNFDNVAMG-----------------YLALLQVATFKGWMD 1371
                   NS+ +   VN    + N + G                 ++A+ QV T +GW+D
Sbjct: 299  GLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 1372 IMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ 1431
            IMY  +D+           + Y ++YF++ II G FF +NL + VI   F++ K++   +
Sbjct: 359  IMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---E 405

Query: 1432 DIFMTEEQKKYYNAMKKLGS 1451
               M E++ ++ +    L S
Sbjct: 406  SQLMREQRVRFLSNASTLAS 425



 Score =  118 bits (296), Expect = 5e-26
 Identities = 82/347 (23%), Positives = 158/347 (45%), Gaps = 49/347 (14%)

Query: 120 RRTAIKVSVHSWFSLFITVTILVNCVCM-------------TRTDLPEKIEYVFTVIYTF 166
           R   ++   + WF     + IL+NCV +              R  + +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGIS--GLRTFRVLRALK 224
           E ++K++A G    +  YL D WN LDF ++    +  ++DL+ +S   +RT RVLR L+
Sbjct: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKND---- 280
            ++ +P ++++V  L+ ++  L +V +L  F   +F +VG+QL+ G L+N+C   +    
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 281 -MAVNETTNYSSHRK---PDIYINKRGT------SDPLLCGNGSDSGHCPDGYICLKTSD 330
            ++V+    Y +  +   P I    R        S P L G+G     C   Y    +S 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS 309

Query: 331 -------------------NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK 371
                              NP     +FD+  +A++++F+++T + W  +    +     
Sbjct: 310 NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF 369

Query: 372 IYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKF 418
              I+F+L+I +GSF+++NL L V+   + E  Q  +  +  +  +F
Sbjct: 370 YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  108 bits (270), Expect = 5e-23
 Identities = 81/351 (23%), Positives = 151/351 (43%), Gaps = 67/351 (19%)

Query: 111  WLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCV--CMTRTDL-PEKIE--------YV 159
            ++F P +  R    ++  H  F   + V I +NC+   M R  + P   E        Y+
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 160  FTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG------ 213
            FT ++  E  +K++A G+C  E  YLR  WN LD  ++ ++ +   + +   SG      
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 214  ---LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKG 270
               LR  R LR L+ +S   GLK++V  L+ S+K + ++ ++      +F ++G+QLFKG
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 271  NLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSD 330
                                                  +C  G D+ +  +   C + S 
Sbjct: 1414 KF-----------------------------------FVC-QGEDTRNITNKSDCAEASY 1437

Query: 331  NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFVLV 380
                +  +FD+   A +SLF L ++D W  +           QQ +       +++F+  
Sbjct: 1438 RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISF 1497

Query: 381  IFLGSFYLVNLILAVVTMAYEEQNQ-ATTDEIEAKEKKFQEALEMLRKEQE 430
            + + +F+++N+ + VV   + +  Q    +E   +E+K    LE  R+ +E
Sbjct: 1498 LLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKE 1548



 Score =  103 bits (257), Expect = 2e-21
 Identities = 78/301 (25%), Positives = 144/301 (47%), Gaps = 36/301 (11%)

Query: 622  EELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIF 681
            +E + +E +C P  +  S             + + ++  L T  + +L IT  I +N + 
Sbjct: 1547 KEKQMAEAQCKPYYSDYS-------------RFRLLVHHLCTSHYLDLFITGVIGLNVVT 1593

Query: 682  MAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSL 741
            MAMEH+      +  L+I N +FT+ F  E VFK++AF    +FQ +WN  D  IV +S+
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653

Query: 742  LELGVAK----------KGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT 791
            + + + +             + ++R  R+ RV KL K    +  L+  +  ++  +GNL 
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713

Query: 792  IILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHDFFHSFLIVFRILCGE- 849
            ++  ++ F+FA +G +L G+   +     + P E   R     +F  +FL +FR+  G+ 
Sbjct: 1714 LLFMLLFFIFAALGVELFGDLECDE----THPCEGLGRHATFRNFGMAFLTLFRVSTGDN 1769

Query: 850  WIENMWACM-EVGQKSICL------ILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPE 902
            W   M   + +  Q+S C       I F++ ++    V++N+ IA+L+      N  A E
Sbjct: 1770 WNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829

Query: 903  D 903
            +
Sbjct: 1830 E 1830



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 98/422 (23%), Positives = 174/422 (41%), Gaps = 118/422 (27%)

Query: 113  FSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTD------LPEKIE---YVFTVI 163
            +S ++  R     +    +  LFIT  I +N V M          L E ++   Y+FTVI
Sbjct: 1560 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1619

Query: 164  YTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---------- 213
            +  E++ K++A GF      + +D WN LD +++ L+ +G  ++   ++           
Sbjct: 1620 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675

Query: 214  -LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
             +R  R+ R LK + +  G++ ++  ++ ++ ++ ++ +L +    +FA +G++LF    
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF---- 1731

Query: 273  KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332
                   D+  +ET                               H  +G          
Sbjct: 1732 ------GDLECDET-------------------------------HPCEGL--------- 1745

Query: 333  DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK--------IYMIFFVLVIFLG 384
               + +F +F  AFL+LFR+ T D+W  + + TLR   +        I  I+FV  +   
Sbjct: 1746 -GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804

Query: 385  SFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHS 444
             F LVN+++AV+    EE N+      EAKE            E E+ A L ++  +L  
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNK------EAKE------------EAELEAELELEMKTLSP 1846

Query: 445  HNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSV 504
               SPL S         + P V    + D+  P +          L  A+  R ASH S+
Sbjct: 1847 QPHSPLGSP-------FLWPGVEGPDSPDSPKPGA----------LHPAAHARSASHFSL 1889

Query: 505  FH 506
             H
Sbjct: 1890 EH 1891



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 68/275 (24%), Positives = 125/275 (45%), Gaps = 36/275 (13%)

Query: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531
            IV  + F   IM+ I +N ++M +E  +Q EE T  L   N  F ++F  E ++K+    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590
             + Y  N +N+FD ++VV+S+  ++                  V+R  R+ R+L+L+R  
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQ----------QGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SSFPHVRWEAGIDDMFNFQT 1646
              ++  L  LM ++  +    +LL L +FI+SI GM      F   R    + D  NF +
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1647 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYI 1706
               +++ +FQI T   W+ +L                      G   + +   ++F   +
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALM 948

Query: 1707 IISFLIMVNMYIAVILENFNVATEESTEPLSEDDF 1741
                 ++ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 949  TFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 68/281 (24%), Positives = 130/281 (46%), Gaps = 45/281 (16%)

Query: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
            T  +IV+  +F   I+  IL+++ S+  E  Y +Q   +   LE ++ VFT +F  EMLL
Sbjct: 735  TFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLL 792

Query: 1204 KWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSR 1263
            K + YG   Y  N +   D +IV IS+  +  +     +   +  LRT R +R L+ +  
Sbjct: 793  KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRF 847

Query: 1264 FEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPL 1323
               ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF    +  DG+      
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGD------ 898

Query: 1324 SIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVN 1383
            ++ + K                   NFD++    + + Q+ T + W  ++Y  + S    
Sbjct: 899  TLPDRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS---- 935

Query: 1384 MQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQ 1424
                   + +  LYF+  + FG +   NL V ++++ F  +
Sbjct: 936  ------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 49/157 (31%), Positives = 79/157 (50%), Gaps = 17/157 (10%)

Query: 1478 FDITIMVLICLNMITMMV----ETDDQSEEKTKILGKINQFFVAVFTGECVMKMFAL--- 1530
            F+   M++I LN +T+ +    E      ++ +IL   + F  A F  E V+KM AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1531 -RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589
             ++ Y  + WN  DF +V+  +  L +S  L+++        F  +R  R+ R LR I  
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGM--LEYSLDLQNVS-------FSAVRTVRVLRPLRAINR 193

Query: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626
               +R L+  L+ +LP L N+ LL F V FI+ I G+
Sbjct: 194  VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 58/209 (27%), Positives = 93/209 (44%), Gaps = 16/209 (7%)

Query: 626 ESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAM- 684
           E+E    P L  +   YL  D  P    L+T     V +P+ E    L I++N + + M 
Sbjct: 47  EAEGLPYPALAPVVFFYLSQDSRPRSWCLRT-----VCNPWFERISMLVILLNCVTLGMF 101

Query: 685 ---EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA---FDPYYYFQKKWNIFDCIIVT 738
              E          +LQ  +     FF  EMV K++A   F    Y    WN  D  IV 
Sbjct: 102 RPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI 161

Query: 739 VSLLELGVAKKG-SLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
             +LE  +  +  S S +R+ R+LR  +     P++  L+ ++ +++  LGN+ ++   +
Sbjct: 162 AGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 221

Query: 798 VFVFALVGKQLLGENYRNN---RKNISAP 823
            F+F +VG QL     RN     +N S P
Sbjct: 222 FFIFGIVGVQLWAGLLRNRCFLPENFSLP 250


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score =  425 bits (1092), Expect = e-118
 Identities = 317/1128 (28%), Positives = 551/1128 (48%), Gaps = 111/1128 (9%)

Query: 671  ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWN 730
            I + I+VNT+ M +E+H         L+I NIVFT  F  EM+ K++ + P+ Y +  +N
Sbjct: 749  IMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808

Query: 731  IFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 790
            IFD +IV +S+ E+   + G LSVLR+FRL+RV KL +  P L   + ++  ++  +   
Sbjct: 809  IFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868

Query: 791  TIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGE- 849
             ++L + +F+F+++G  L G  + + R   + P     R +      + + VF+IL  E 
Sbjct: 869  CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPD----RKNFDSLLWAIVTVFQILTQED 924

Query: 850  WIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSAD----------NLT 899
            W + ++  M     S   + F+ +M  GN V+ NL +A+L+  F A+          +  
Sbjct: 925  WNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFF 983

Query: 900  APEDDGEVNNLQVALARIQVFGH-RTKQALCS---FFSRSCPFPQPKAEPELVVKLPLSS 955
            +P  DG+  + +  LA + +  H   +++L       + + P   PK+    + +  L  
Sbjct: 984  SPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEA-LGP 1041

Query: 956  SKAENHIAANTARGSSGGLQAPRGPRDE-HSDFIANPTVWVSVPIAE---GESDLDDLED 1011
            +      + +   G++  +++P   R   HS + A  + W S   +    G +       
Sbjct: 1042 ASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS-WTSRRSSRNSLGRAPSLKRRS 1100

Query: 1012 DGGEDAQSFQQEVIPKGQQEQLQQVERCG----DHLTPRS-PGTGTSSEDLAPSLGETWK 1066
              GE       E      +E+  + ER      DH    S      SS DL  +L     
Sbjct: 1101 PSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTL----- 1155

Query: 1067 DESVPQVPAEGVDDTSSSEGSTV---DCLDPEEILRKIPELADDLE--EPDDCFTEGCIR 1121
                 QVP  G+  T+S  GS     DC       R    L  D    + DD   EG + 
Sbjct: 1156 -----QVP--GLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLS 1208

Query: 1122 -----------HCPCCKLDTTKSPWDV-----GWQVRKTCYRIVEHSWFESFIIFMILLS 1165
                         P C L+  +  W         + R  C+RI+ H  F+  ++ +I L+
Sbjct: 1209 KGERVRAWIRARLPACCLE--RDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLN 1266

Query: 1166 SGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGF----KKYFTNAWCWL 1221
              ++A E   +D     +  L  ++ +FT +F+ EM +K VA G+    + Y  ++W  L
Sbjct: 1267 CITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVL 1326

Query: 1222 DFLIVNISLISLTAKILEYSE---VAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAI 1278
            D L+V IS+I +   ++  S    +  ++ LR LR LRPLR +SR +G+++VV+ L+ ++
Sbjct: 1327 DGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSL 1386

Query: 1279 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNST 1338
              I N++++C  F++IF I+GV LF GKF+ C     GE +      + NKSDC    + 
Sbjct: 1387 KPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDT----RNITNKSDC----AE 1434

Query: 1339 GSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYF 1398
             S+ WV  K NFDN+    ++L  +A+  GW+DIMY  +D+  V+ QP    N +M LYF
Sbjct: 1435 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1494

Query: 1399 VIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ--- 1455
            + F++   FF LN+FVGV+++NF++ ++    ++     E+K+     KK  SK+ Q   
Sbjct: 1495 ISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQMAE 1553

Query: 1456 ---KPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKIN 1512
               KP     ++F+  V  + T    D+ I  +I LN++TM +E   Q +   + L   N
Sbjct: 1554 AQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICN 1613

Query: 1513 QFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTL 1571
              F  +F  E V K+ A   + +F + WN  D  +V+LSI  +    I  +     +PT+
Sbjct: 1614 YIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTI 1673

Query: 1572 FRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPH 1631
             R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  F  
Sbjct: 1674 IRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1733

Query: 1632 VRWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSN 1686
            +  +      G+     F+ F  + L LF+++T   W+G++   L      CD       
Sbjct: 1734 LECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD------- 1782

Query: 1687 GTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTE 1734
                 C +  +  I+F ++++ +  ++VN+ IAV++++   + +E+ E
Sbjct: 1783 -QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829



 Score =  149 bits (375), Expect = 3e-35
 Identities = 186/876 (21%), Positives = 350/876 (39%), Gaps = 168/876 (19%)

Query: 105  SATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCM---------TRTDLPEK 155
            S+  A W      LI  T  K+    +F   I + ILVN + M           T+  E 
Sbjct: 723  SSVLAFW-----RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEI 777

Query: 156  IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG--ISG 213
               VFT ++  E L+K+L  G     F Y+++P+N  D  VI +  V   +  +G  +S 
Sbjct: 778  SNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSV 832

Query: 214  LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLK 273
            LRTFR++R LK V  +P L+  +  L+ ++  +A   +L +  + +F+++G+ LF     
Sbjct: 833  LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---- 888

Query: 274  NKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPD 333
                           ++S R  D   +++                               
Sbjct: 889  -------------CKFASERDGDTLPDRK------------------------------- 904

Query: 334  FNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLIL 393
                +FDS  WA +++F+++TQ+ W ++    + ++     ++F+ ++  G++ L NL++
Sbjct: 905  ----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 394  AVVTMAYEEQNQATTDEIEAK----------EKKFQEALEMLRKEQEVLAALGIDTTSLH 443
            A++   ++ +  A   E E            ++K   AL  L +  E+  +L +    +H
Sbjct: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIH 1019

Query: 444  SHNGSPLTSKNAS----------ERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLA 493
            +        K+ S           RR         G+  + KSP S   +         +
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1079

Query: 494  SGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSP 553
               RR+S  S+   R+P      P G              R SLL G G   Q     S 
Sbjct: 1080 WTSRRSSRNSLG--RAPSLKRRSPSG-------------ERRSLLSGEGQESQDEEESSE 1124

Query: 554  LPQ--PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAM 611
              +  P+  D RH     +   +S   P  + V            ++E+ D     + A 
Sbjct: 1125 EERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQD--CNGKSAS 1182

Query: 612  SVVSIITSVLEELEESEQKCPPCLTSLSQKYLIW------DCC-----------PMWVKL 654
              ++      +   + +        S  ++   W       CC           P   + 
Sbjct: 1183 GRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRF 1242

Query: 655  KTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP--TFEAMLQIGNIVFTIFFTAEM 712
            + +   ++T    +  + + I +N I +AME   + P       L + N +FT  F AEM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 713  VFKIIA----FDPYYYFQKKWNIFDCIIVTVSLLEL--------GVAKKGSLSVLRSFRL 760
              K++A    F    Y +  WN+ D ++V +S++++        G    G L VLR  R 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 761  LRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLL--------GEN 812
            LR  ++      L  +++ + +S+  +GN+ +I      +F ++G QL         GE+
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422

Query: 813  YRN--NRKNISAPHEDWPRWHMHDF--FHSFLIVFRILCGE--WIENMWACME---VGQK 863
             RN  N+ + +     W R H ++F      L+   +L  +  W++ M+  ++   V Q+
Sbjct: 1423 TRNITNKSDCAEASYRWVR-HKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQ 1481

Query: 864  SI------CLILFLTVMVLGNLVVLNLFIALLLNSF 893
             I       L+ F++ +++    VLN+F+ +++ +F
Sbjct: 1482 PIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  128 bits (321), Expect = 6e-29
 Identities = 112/380 (29%), Positives = 171/380 (45%), Gaps = 95/380 (25%)

Query: 1142 RKTCYRIVEHSWFESFIIFMILLSSGSLAF----EDYYLDQKPTVKALLEYTDRVFTFIF 1197
            R  C R V + WFE   + +ILL+  +L      ED   D +   + L  + D +F F F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFAF-F 128

Query: 1198 VFEMLLKWVA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIKALRT 1251
              EM++K VA   +G K Y  + W  LDF IV        A +LEYS   +     A+RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RC 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    RC
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241

Query: 1311 INYTDGEFSLVPLSI----------------------VNNKSDCK--------------- 1333
              +    FSL PLS+                       N    C+               
Sbjct: 242  --FLPENFSL-PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPC 298

Query: 1334 -----IQNSTGSFFWVNVKVNFDNVAMG-----------------YLALLQVATFKGWMD 1371
                   NS+ +   VN    + N + G                 ++A+ QV T +GW+D
Sbjct: 299  GLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 1372 IMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ 1431
            IMY  +D+           + Y ++YF++ II G FF +NL + VI   F++ K++   +
Sbjct: 359  IMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---E 405

Query: 1432 DIFMTEEQKKYYNAMKKLGS 1451
               M E++ ++ +    L S
Sbjct: 406  SQLMREQRVRFLSNASTLAS 425



 Score =  118 bits (296), Expect = 5e-26
 Identities = 82/347 (23%), Positives = 158/347 (45%), Gaps = 49/347 (14%)

Query: 120 RRTAIKVSVHSWFSLFITVTILVNCVCM-------------TRTDLPEKIEYVFTVIYTF 166
           R   ++   + WF     + IL+NCV +              R  + +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGIS--GLRTFRVLRALK 224
           E ++K++A G    +  YL D WN LDF ++    +  ++DL+ +S   +RT RVLR L+
Sbjct: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKND---- 280
            ++ +P ++++V  L+ ++  L +V +L  F   +F +VG+QL+ G L+N+C   +    
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 281 -MAVNETTNYSSHRK---PDIYINKRGT------SDPLLCGNGSDSGHCPDGYICLKTSD 330
            ++V+    Y +  +   P I    R        S P L G+G     C   Y    +S 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS 309

Query: 331 -------------------NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK 371
                              NP     +FD+  +A++++F+++T + W  +    +     
Sbjct: 310 NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF 369

Query: 372 IYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKF 418
              I+F+L+I +GSF+++NL L V+   + E  Q  +  +  +  +F
Sbjct: 370 YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  108 bits (270), Expect = 5e-23
 Identities = 81/351 (23%), Positives = 151/351 (43%), Gaps = 67/351 (19%)

Query: 111  WLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCV--CMTRTDL-PEKIE--------YV 159
            ++F P +  R    ++  H  F   + V I +NC+   M R  + P   E        Y+
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 160  FTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG------ 213
            FT ++  E  +K++A G+C  E  YLR  WN LD  ++ ++ +   + +   SG      
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 214  ---LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKG 270
               LR  R LR L+ +S   GLK++V  L+ S+K + ++ ++      +F ++G+QLFKG
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 271  NLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSD 330
                                                  +C  G D+ +  +   C + S 
Sbjct: 1414 KF-----------------------------------FVC-QGEDTRNITNKSDCAEASY 1437

Query: 331  NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFVLV 380
                +  +FD+   A +SLF L ++D W  +           QQ +       +++F+  
Sbjct: 1438 RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISF 1497

Query: 381  IFLGSFYLVNLILAVVTMAYEEQNQ-ATTDEIEAKEKKFQEALEMLRKEQE 430
            + + +F+++N+ + VV   + +  Q    +E   +E+K    LE  R+ +E
Sbjct: 1498 LLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKE 1548



 Score =  103 bits (257), Expect = 2e-21
 Identities = 78/301 (25%), Positives = 144/301 (47%), Gaps = 36/301 (11%)

Query: 622  EELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIF 681
            +E + +E +C P  +  S             + + ++  L T  + +L IT  I +N + 
Sbjct: 1547 KEKQMAEAQCKPYYSDYS-------------RFRLLVHHLCTSHYLDLFITGVIGLNVVT 1593

Query: 682  MAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSL 741
            MAMEH+      +  L+I N +FT+ F  E VFK++AF    +FQ +WN  D  IV +S+
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653

Query: 742  LELGVAK----------KGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT 791
            + + + +             + ++R  R+ RV KL K    +  L+  +  ++  +GNL 
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713

Query: 792  IILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHDFFHSFLIVFRILCGE- 849
            ++  ++ F+FA +G +L G+   +     + P E   R     +F  +FL +FR+  G+ 
Sbjct: 1714 LLFMLLFFIFAALGVELFGDLECDE----THPCEGLGRHATFRNFGMAFLTLFRVSTGDN 1769

Query: 850  WIENMWACM-EVGQKSICL------ILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPE 902
            W   M   + +  Q+S C       I F++ ++    V++N+ IA+L+      N  A E
Sbjct: 1770 WNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829

Query: 903  D 903
            +
Sbjct: 1830 E 1830



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 109/472 (23%), Positives = 188/472 (39%), Gaps = 127/472 (26%)

Query: 113  FSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTD------LPEKIE---YVFTVI 163
            +S ++  R     +    +  LFIT  I +N V M          L E ++   Y+FTVI
Sbjct: 1560 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1619

Query: 164  YTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---------- 213
            +  E++ K++A GF      + +D WN LD +++ L+ +G  ++   ++           
Sbjct: 1620 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675

Query: 214  -LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
             +R  R+ R LK + +  G++ ++  ++ ++ ++ ++ +L +    +FA +G++LF    
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF---- 1731

Query: 273  KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332
                   D+  +ET                               H  +G          
Sbjct: 1732 ------GDLECDET-------------------------------HPCEGL--------- 1745

Query: 333  DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK--------IYMIFFVLVIFLG 384
               + +F +F  AFL+LFR+ T D+W  + + TLR   +        I  I+FV  +   
Sbjct: 1746 -GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804

Query: 385  SFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHS 444
             F LVN+++AV+    EE N+      EAKE            E E+ A L ++  +L  
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNK------EAKE------------EAELEAELELEMKTLSP 1846

Query: 445  HNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSV 504
               SPL S         + P V    + D+  P +          L  A+  R ASH S+
Sbjct: 1847 QPHSPLGSP-------FLWPGVEGPDSPDSPKPGA----------LHPAAHARSASHFSL 1889

Query: 505  FH-------FRSPGRDISL--PEGVTDDGVFPGDHESHRGSLLLGGGAGQQG 547
             H          PG D+      GV+     P D    R      G  G +G
Sbjct: 1890 EHPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRG 1941



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 68/275 (24%), Positives = 125/275 (45%), Gaps = 36/275 (13%)

Query: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531
            IV  + F   IM+ I +N ++M +E  +Q EE T  L   N  F ++F  E ++K+    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590
             + Y  N +N+FD ++VV+S+  ++                  V+R  R+ R+L+L+R  
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQ----------QGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SSFPHVRWEAGIDDMFNFQT 1646
              ++  L  LM ++  +    +LL L +FI+SI GM      F   R    + D  NF +
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1647 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYI 1706
               +++ +FQI T   W+ +L                      G   + +   ++F   +
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALM 948

Query: 1707 IISFLIMVNMYIAVILENFNVATEESTEPLSEDDF 1741
                 ++ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 949  TFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 68/281 (24%), Positives = 130/281 (46%), Gaps = 45/281 (16%)

Query: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
            T  +IV+  +F   I+  IL+++ S+  E  Y +Q   +   LE ++ VFT +F  EMLL
Sbjct: 735  TFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLL 792

Query: 1204 KWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSR 1263
            K + YG   Y  N +   D +IV IS+  +  +     +   +  LRT R +R L+ +  
Sbjct: 793  KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRF 847

Query: 1264 FEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPL 1323
               ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF    +  DG+      
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGD------ 898

Query: 1324 SIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVN 1383
            ++ + K                   NFD++    + + Q+ T + W  ++Y  + S    
Sbjct: 899  TLPDRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS---- 935

Query: 1384 MQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQ 1424
                   + +  LYF+  + FG +   NL V ++++ F  +
Sbjct: 936  ------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 49/157 (31%), Positives = 79/157 (50%), Gaps = 17/157 (10%)

Query: 1478 FDITIMVLICLNMITMMV----ETDDQSEEKTKILGKINQFFVAVFTGECVMKMFAL--- 1530
            F+   M++I LN +T+ +    E      ++ +IL   + F  A F  E V+KM AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1531 -RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589
             ++ Y  + WN  DF +V+  +  L +S  L+++        F  +R  R+ R LR I  
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGM--LEYSLDLQNVS-------FSAVRTVRVLRPLRAINR 193

Query: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626
               +R L+  L+ +LP L N+ LL F V FI+ I G+
Sbjct: 194  VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 58/209 (27%), Positives = 93/209 (44%), Gaps = 16/209 (7%)

Query: 626 ESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAM- 684
           E+E    P L  +   YL  D  P    L+T     V +P+ E    L I++N + + M 
Sbjct: 47  EAEGLPYPALAPVVFFYLSQDSRPRSWCLRT-----VCNPWFERISMLVILLNCVTLGMF 101

Query: 685 ---EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA---FDPYYYFQKKWNIFDCIIVT 738
              E          +LQ  +     FF  EMV K++A   F    Y    WN  D  IV 
Sbjct: 102 RPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI 161

Query: 739 VSLLELGVAKKG-SLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
             +LE  +  +  S S +R+ R+LR  +     P++  L+ ++ +++  LGN+ ++   +
Sbjct: 162 AGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 221

Query: 798 VFVFALVGKQLLGENYRNN---RKNISAP 823
            F+F +VG QL     RN     +N S P
Sbjct: 222 FFIFGIVGVQLWAGLLRNRCFLPENFSLP 250


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score =  425 bits (1092), Expect = e-118
 Identities = 317/1128 (28%), Positives = 551/1128 (48%), Gaps = 111/1128 (9%)

Query: 671  ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWN 730
            I + I+VNT+ M +E+H         L+I NIVFT  F  EM+ K++ + P+ Y +  +N
Sbjct: 749  IMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808

Query: 731  IFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 790
            IFD +IV +S+ E+   + G LSVLR+FRL+RV KL +  P L   + ++  ++  +   
Sbjct: 809  IFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868

Query: 791  TIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGE- 849
             ++L + +F+F+++G  L G  + + R   + P     R +      + + VF+IL  E 
Sbjct: 869  CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPD----RKNFDSLLWAIVTVFQILTQED 924

Query: 850  WIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSAD----------NLT 899
            W + ++  M     S   + F+ +M  GN V+ NL +A+L+  F A+          +  
Sbjct: 925  WNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFF 983

Query: 900  APEDDGEVNNLQVALARIQVFGH-RTKQALCS---FFSRSCPFPQPKAEPELVVKLPLSS 955
            +P  DG+  + +  LA + +  H   +++L       + + P   PK+    + +  L  
Sbjct: 984  SPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEA-LGP 1041

Query: 956  SKAENHIAANTARGSSGGLQAPRGPRDE-HSDFIANPTVWVSVPIAE---GESDLDDLED 1011
            +      + +   G++  +++P   R   HS + A  + W S   +    G +       
Sbjct: 1042 ASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS-WTSRRSSRNSLGRAPSLKRRS 1100

Query: 1012 DGGEDAQSFQQEVIPKGQQEQLQQVERCG----DHLTPRS-PGTGTSSEDLAPSLGETWK 1066
              GE       E      +E+  + ER      DH    S      SS DL  +L     
Sbjct: 1101 PSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTL----- 1155

Query: 1067 DESVPQVPAEGVDDTSSSEGSTV---DCLDPEEILRKIPELADDLE--EPDDCFTEGCIR 1121
                 QVP  G+  T+S  GS     DC       R    L  D    + DD   EG + 
Sbjct: 1156 -----QVP--GLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLS 1208

Query: 1122 -----------HCPCCKLDTTKSPWDV-----GWQVRKTCYRIVEHSWFESFIIFMILLS 1165
                         P C L+  +  W         + R  C+RI+ H  F+  ++ +I L+
Sbjct: 1209 KGERVRAWIRARLPACCLE--RDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLN 1266

Query: 1166 SGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGF----KKYFTNAWCWL 1221
              ++A E   +D     +  L  ++ +FT +F+ EM +K VA G+    + Y  ++W  L
Sbjct: 1267 CITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVL 1326

Query: 1222 DFLIVNISLISLTAKILEYSE---VAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAI 1278
            D L+V IS+I +   ++  S    +  ++ LR LR LRPLR +SR +G+++VV+ L+ ++
Sbjct: 1327 DGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSL 1386

Query: 1279 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNST 1338
              I N++++C  F++IF I+GV LF GKF+ C     GE +      + NKSDC    + 
Sbjct: 1387 KPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDT----RNITNKSDC----AE 1434

Query: 1339 GSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYF 1398
             S+ WV  K NFDN+    ++L  +A+  GW+DIMY  +D+  V+ QP    N +M LYF
Sbjct: 1435 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1494

Query: 1399 VIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ--- 1455
            + F++   FF LN+FVGV+++NF++ ++    ++     E+K+     KK  SK+ Q   
Sbjct: 1495 ISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQMAE 1553

Query: 1456 ---KPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKIN 1512
               KP     ++F+  V  + T    D+ I  +I LN++TM +E   Q +   + L   N
Sbjct: 1554 AQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICN 1613

Query: 1513 QFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTL 1571
              F  +F  E V K+ A   + +F + WN  D  +V+LSI  +    I  +     +PT+
Sbjct: 1614 YIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTI 1673

Query: 1572 FRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPH 1631
             R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  F  
Sbjct: 1674 IRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1733

Query: 1632 VRWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSN 1686
            +  +      G+     F+ F  + L LF+++T   W+G++   L      CD       
Sbjct: 1734 LECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD------- 1782

Query: 1687 GTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTE 1734
                 C +  +  I+F ++++ +  ++VN+ IAV++++   + +E+ E
Sbjct: 1783 -QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829



 Score =  149 bits (375), Expect = 3e-35
 Identities = 186/876 (21%), Positives = 350/876 (39%), Gaps = 168/876 (19%)

Query: 105  SATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCM---------TRTDLPEK 155
            S+  A W      LI  T  K+    +F   I + ILVN + M           T+  E 
Sbjct: 723  SSVLAFW-----RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEI 777

Query: 156  IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG--ISG 213
               VFT ++  E L+K+L  G     F Y+++P+N  D  VI +  V   +  +G  +S 
Sbjct: 778  SNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSV 832

Query: 214  LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLK 273
            LRTFR++R LK V  +P L+  +  L+ ++  +A   +L +  + +F+++G+ LF     
Sbjct: 833  LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---- 888

Query: 274  NKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPD 333
                           ++S R  D   +++                               
Sbjct: 889  -------------CKFASERDGDTLPDRK------------------------------- 904

Query: 334  FNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLIL 393
                +FDS  WA +++F+++TQ+ W ++    + ++     ++F+ ++  G++ L NL++
Sbjct: 905  ----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 394  AVVTMAYEEQNQATTDEIEAK----------EKKFQEALEMLRKEQEVLAALGIDTTSLH 443
            A++   ++ +  A   E E            ++K   AL  L +  E+  +L +    +H
Sbjct: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIH 1019

Query: 444  SHNGSPLTSKNAS----------ERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLA 493
            +        K+ S           RR         G+  + KSP S   +         +
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1079

Query: 494  SGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSP 553
               RR+S  S+   R+P      P G              R SLL G G   Q     S 
Sbjct: 1080 WTSRRSSRNSLG--RAPSLKRRSPSG-------------ERRSLLSGEGQESQDEEESSE 1124

Query: 554  LPQ--PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAM 611
              +  P+  D RH     +   +S   P  + V            ++E+ D     + A 
Sbjct: 1125 EERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQD--CNGKSAS 1182

Query: 612  SVVSIITSVLEELEESEQKCPPCLTSLSQKYLIW------DCC-----------PMWVKL 654
              ++      +   + +        S  ++   W       CC           P   + 
Sbjct: 1183 GRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRF 1242

Query: 655  KTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP--TFEAMLQIGNIVFTIFFTAEM 712
            + +   ++T    +  + + I +N I +AME   + P       L + N +FT  F AEM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 713  VFKIIA----FDPYYYFQKKWNIFDCIIVTVSLLEL--------GVAKKGSLSVLRSFRL 760
              K++A    F    Y +  WN+ D ++V +S++++        G    G L VLR  R 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 761  LRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLL--------GEN 812
            LR  ++      L  +++ + +S+  +GN+ +I      +F ++G QL         GE+
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422

Query: 813  YRN--NRKNISAPHEDWPRWHMHDF--FHSFLIVFRILCGE--WIENMWACME---VGQK 863
             RN  N+ + +     W R H ++F      L+   +L  +  W++ M+  ++   V Q+
Sbjct: 1423 TRNITNKSDCAEASYRWVR-HKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQ 1481

Query: 864  SI------CLILFLTVMVLGNLVVLNLFIALLLNSF 893
             I       L+ F++ +++    VLN+F+ +++ +F
Sbjct: 1482 PIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  128 bits (321), Expect = 6e-29
 Identities = 112/380 (29%), Positives = 171/380 (45%), Gaps = 95/380 (25%)

Query: 1142 RKTCYRIVEHSWFESFIIFMILLSSGSLAF----EDYYLDQKPTVKALLEYTDRVFTFIF 1197
            R  C R V + WFE   + +ILL+  +L      ED   D +   + L  + D +F F F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFAF-F 128

Query: 1198 VFEMLLKWVA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIKALRT 1251
              EM++K VA   +G K Y  + W  LDF IV        A +LEYS   +     A+RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RC 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    RC
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241

Query: 1311 INYTDGEFSLVPLSI----------------------VNNKSDCK--------------- 1333
              +    FSL PLS+                       N    C+               
Sbjct: 242  --FLPENFSL-PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPC 298

Query: 1334 -----IQNSTGSFFWVNVKVNFDNVAMG-----------------YLALLQVATFKGWMD 1371
                   NS+ +   VN    + N + G                 ++A+ QV T +GW+D
Sbjct: 299  GLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 1372 IMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ 1431
            IMY  +D+           + Y ++YF++ II G FF +NL + VI   F++ K++   +
Sbjct: 359  IMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---E 405

Query: 1432 DIFMTEEQKKYYNAMKKLGS 1451
               M E++ ++ +    L S
Sbjct: 406  SQLMREQRVRFLSNASTLAS 425



 Score =  118 bits (296), Expect = 5e-26
 Identities = 82/347 (23%), Positives = 158/347 (45%), Gaps = 49/347 (14%)

Query: 120 RRTAIKVSVHSWFSLFITVTILVNCVCM-------------TRTDLPEKIEYVFTVIYTF 166
           R   ++   + WF     + IL+NCV +              R  + +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGIS--GLRTFRVLRALK 224
           E ++K++A G    +  YL D WN LDF ++    +  ++DL+ +S   +RT RVLR L+
Sbjct: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKND---- 280
            ++ +P ++++V  L+ ++  L +V +L  F   +F +VG+QL+ G L+N+C   +    
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 281 -MAVNETTNYSSHRK---PDIYINKRGT------SDPLLCGNGSDSGHCPDGYICLKTSD 330
            ++V+    Y +  +   P I    R        S P L G+G     C   Y    +S 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS 309

Query: 331 -------------------NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK 371
                              NP     +FD+  +A++++F+++T + W  +    +     
Sbjct: 310 NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF 369

Query: 372 IYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKF 418
              I+F+L+I +GSF+++NL L V+   + E  Q  +  +  +  +F
Sbjct: 370 YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  108 bits (270), Expect = 5e-23
 Identities = 81/351 (23%), Positives = 151/351 (43%), Gaps = 67/351 (19%)

Query: 111  WLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCV--CMTRTDL-PEKIE--------YV 159
            ++F P +  R    ++  H  F   + V I +NC+   M R  + P   E        Y+
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 160  FTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG------ 213
            FT ++  E  +K++A G+C  E  YLR  WN LD  ++ ++ +   + +   SG      
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 214  ---LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKG 270
               LR  R LR L+ +S   GLK++V  L+ S+K + ++ ++      +F ++G+QLFKG
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 271  NLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSD 330
                                                  +C  G D+ +  +   C + S 
Sbjct: 1414 KF-----------------------------------FVC-QGEDTRNITNKSDCAEASY 1437

Query: 331  NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFVLV 380
                +  +FD+   A +SLF L ++D W  +           QQ +       +++F+  
Sbjct: 1438 RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISF 1497

Query: 381  IFLGSFYLVNLILAVVTMAYEEQNQ-ATTDEIEAKEKKFQEALEMLRKEQE 430
            + + +F+++N+ + VV   + +  Q    +E   +E+K    LE  R+ +E
Sbjct: 1498 LLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKE 1548



 Score =  103 bits (257), Expect = 2e-21
 Identities = 78/301 (25%), Positives = 144/301 (47%), Gaps = 36/301 (11%)

Query: 622  EELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIF 681
            +E + +E +C P  +  S             + + ++  L T  + +L IT  I +N + 
Sbjct: 1547 KEKQMAEAQCKPYYSDYS-------------RFRLLVHHLCTSHYLDLFITGVIGLNVVT 1593

Query: 682  MAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSL 741
            MAMEH+      +  L+I N +FT+ F  E VFK++AF    +FQ +WN  D  IV +S+
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653

Query: 742  LELGVAK----------KGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT 791
            + + + +             + ++R  R+ RV KL K    +  L+  +  ++  +GNL 
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713

Query: 792  IILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHDFFHSFLIVFRILCGE- 849
            ++  ++ F+FA +G +L G+   +     + P E   R     +F  +FL +FR+  G+ 
Sbjct: 1714 LLFMLLFFIFAALGVELFGDLECDE----THPCEGLGRHATFRNFGMAFLTLFRVSTGDN 1769

Query: 850  WIENMWACM-EVGQKSICL------ILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPE 902
            W   M   + +  Q+S C       I F++ ++    V++N+ IA+L+      N  A E
Sbjct: 1770 WNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829

Query: 903  D 903
            +
Sbjct: 1830 E 1830



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 118/508 (23%), Positives = 200/508 (39%), Gaps = 146/508 (28%)

Query: 113  FSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTD------LPEKIE---YVFTVI 163
            +S ++  R     +    +  LFIT  I +N V M          L E ++   Y+FTVI
Sbjct: 1560 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1619

Query: 164  YTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---------- 213
            +  E++ K++A GF      + +D WN LD +++ L+ +G  ++   ++           
Sbjct: 1620 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675

Query: 214  -LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
             +R  R+ R LK + +  G++ ++  ++ ++ ++ ++ +L +    +FA +G++LF    
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF---- 1731

Query: 273  KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332
                   D+  +ET                               H  +G          
Sbjct: 1732 ------GDLECDET-------------------------------HPCEGL--------- 1745

Query: 333  DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK--------IYMIFFVLVIFLG 384
               + +F +F  AFL+LFR+ T D+W  + + TLR   +        I  I+FV  +   
Sbjct: 1746 -GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804

Query: 385  SFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHS 444
             F LVN+++AV+    EE N+      EAKE            E E+ A L ++  +L  
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNK------EAKE------------EAELEAELELEMKTLSP 1846

Query: 445  HNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSV 504
               SPL S         + P V    + D+  P +          L  A+  R ASH S+
Sbjct: 1847 QPHSPLGSP-------FLWPGVEGPDSPDSPKPGA----------LHPAAHARSASHFSL 1889

Query: 505  FHFRSPGRDISLPEGVTDDGVFPGDHESHRGSL--------LLGGGAGQQGPLPRSPLPQ 556
             H              TD  +F       +GSL         L G  GQ    P +P   
Sbjct: 1890 EH-------------PTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLG 1936

Query: 557  PSNPDSRHGEDEHQPPPTSELAPGAVDV 584
             S+P       + QP PT    P  + V
Sbjct: 1937 GSDP-------QMQPHPTELPGPDLLTV 1957



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 68/275 (24%), Positives = 125/275 (45%), Gaps = 36/275 (13%)

Query: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531
            IV  + F   IM+ I +N ++M +E  +Q EE T  L   N  F ++F  E ++K+    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590
             + Y  N +N+FD ++VV+S+  ++                  V+R  R+ R+L+L+R  
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQ----------QGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SSFPHVRWEAGIDDMFNFQT 1646
              ++  L  LM ++  +    +LL L +FI+SI GM      F   R    + D  NF +
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1647 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYI 1706
               +++ +FQI T   W+ +L                      G   + +   ++F   +
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALM 948

Query: 1707 IISFLIMVNMYIAVILENFNVATEESTEPLSEDDF 1741
                 ++ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 949  TFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 68/281 (24%), Positives = 130/281 (46%), Gaps = 45/281 (16%)

Query: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
            T  +IV+  +F   I+  IL+++ S+  E  Y +Q   +   LE ++ VFT +F  EMLL
Sbjct: 735  TFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLL 792

Query: 1204 KWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSR 1263
            K + YG   Y  N +   D +IV IS+  +  +     +   +  LRT R +R L+ +  
Sbjct: 793  KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRF 847

Query: 1264 FEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPL 1323
               ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF    +  DG+      
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGD------ 898

Query: 1324 SIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVN 1383
            ++ + K                   NFD++    + + Q+ T + W  ++Y  + S    
Sbjct: 899  TLPDRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS---- 935

Query: 1384 MQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQ 1424
                   + +  LYF+  + FG +   NL V ++++ F  +
Sbjct: 936  ------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 49/157 (31%), Positives = 79/157 (50%), Gaps = 17/157 (10%)

Query: 1478 FDITIMVLICLNMITMMV----ETDDQSEEKTKILGKINQFFVAVFTGECVMKMFAL--- 1530
            F+   M++I LN +T+ +    E      ++ +IL   + F  A F  E V+KM AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1531 -RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589
             ++ Y  + WN  DF +V+  +  L +S  L+++        F  +R  R+ R LR I  
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGM--LEYSLDLQNVS-------FSAVRTVRVLRPLRAINR 193

Query: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626
               +R L+  L+ +LP L N+ LL F V FI+ I G+
Sbjct: 194  VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 58/209 (27%), Positives = 93/209 (44%), Gaps = 16/209 (7%)

Query: 626 ESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAM- 684
           E+E    P L  +   YL  D  P    L+T     V +P+ E    L I++N + + M 
Sbjct: 47  EAEGLPYPALAPVVFFYLSQDSRPRSWCLRT-----VCNPWFERISMLVILLNCVTLGMF 101

Query: 685 ---EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA---FDPYYYFQKKWNIFDCIIVT 738
              E          +LQ  +     FF  EMV K++A   F    Y    WN  D  IV 
Sbjct: 102 RPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI 161

Query: 739 VSLLELGVAKKG-SLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
             +LE  +  +  S S +R+ R+LR  +     P++  L+ ++ +++  LGN+ ++   +
Sbjct: 162 AGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 221

Query: 798 VFVFALVGKQLLGENYRNN---RKNISAP 823
            F+F +VG QL     RN     +N S P
Sbjct: 222 FFIFGIVGVQLWAGLLRNRCFLPENFSLP 250


>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
            isoform 14 [Homo sapiens]
          Length = 2171

 Score =  425 bits (1092), Expect = e-118
 Identities = 317/1128 (28%), Positives = 551/1128 (48%), Gaps = 111/1128 (9%)

Query: 671  ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWN 730
            I + I+VNT+ M +E+H         L+I NIVFT  F  EM+ K++ + P+ Y +  +N
Sbjct: 749  IMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808

Query: 731  IFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 790
            IFD +IV +S+ E+   + G LSVLR+FRL+RV KL +  P L   + ++  ++  +   
Sbjct: 809  IFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868

Query: 791  TIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGE- 849
             ++L + +F+F+++G  L G  + + R   + P     R +      + + VF+IL  E 
Sbjct: 869  CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPD----RKNFDSLLWAIVTVFQILTQED 924

Query: 850  WIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSAD----------NLT 899
            W + ++  M     S   + F+ +M  GN V+ NL +A+L+  F A+          +  
Sbjct: 925  WNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFF 983

Query: 900  APEDDGEVNNLQVALARIQVFGH-RTKQALCS---FFSRSCPFPQPKAEPELVVKLPLSS 955
            +P  DG+  + +  LA + +  H   +++L       + + P   PK+    + +  L  
Sbjct: 984  SPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEA-LGP 1041

Query: 956  SKAENHIAANTARGSSGGLQAPRGPRDE-HSDFIANPTVWVSVPIAE---GESDLDDLED 1011
            +      + +   G++  +++P   R   HS + A  + W S   +    G +       
Sbjct: 1042 ASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS-WTSRRSSRNSLGRAPSLKRRS 1100

Query: 1012 DGGEDAQSFQQEVIPKGQQEQLQQVERCG----DHLTPRS-PGTGTSSEDLAPSLGETWK 1066
              GE       E      +E+  + ER      DH    S      SS DL  +L     
Sbjct: 1101 PSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTL----- 1155

Query: 1067 DESVPQVPAEGVDDTSSSEGSTV---DCLDPEEILRKIPELADDLE--EPDDCFTEGCIR 1121
                 QVP  G+  T+S  GS     DC       R    L  D    + DD   EG + 
Sbjct: 1156 -----QVP--GLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLS 1208

Query: 1122 -----------HCPCCKLDTTKSPWDV-----GWQVRKTCYRIVEHSWFESFIIFMILLS 1165
                         P C L+  +  W         + R  C+RI+ H  F+  ++ +I L+
Sbjct: 1209 KGERVRAWIRARLPACCLE--RDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLN 1266

Query: 1166 SGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGF----KKYFTNAWCWL 1221
              ++A E   +D     +  L  ++ +FT +F+ EM +K VA G+    + Y  ++W  L
Sbjct: 1267 CITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVL 1326

Query: 1222 DFLIVNISLISLTAKILEYSE---VAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAI 1278
            D L+V IS+I +   ++  S    +  ++ LR LR LRPLR +SR +G+++VV+ L+ ++
Sbjct: 1327 DGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSL 1386

Query: 1279 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNST 1338
              I N++++C  F++IF I+GV LF GKF+ C     GE +      + NKSDC    + 
Sbjct: 1387 KPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDT----RNITNKSDC----AE 1434

Query: 1339 GSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYF 1398
             S+ WV  K NFDN+    ++L  +A+  GW+DIMY  +D+  V+ QP    N +M LYF
Sbjct: 1435 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1494

Query: 1399 VIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ--- 1455
            + F++   FF LN+FVGV+++NF++ ++    ++     E+K+     KK  SK+ Q   
Sbjct: 1495 ISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQMAE 1553

Query: 1456 ---KPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKIN 1512
               KP     ++F+  V  + T    D+ I  +I LN++TM +E   Q +   + L   N
Sbjct: 1554 AQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICN 1613

Query: 1513 QFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTL 1571
              F  +F  E V K+ A   + +F + WN  D  +V+LSI  +    I  +     +PT+
Sbjct: 1614 YIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTI 1673

Query: 1572 FRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPH 1631
             R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  F  
Sbjct: 1674 IRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1733

Query: 1632 VRWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSN 1686
            +  +      G+     F+ F  + L LF+++T   W+G++   L      CD       
Sbjct: 1734 LECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD------- 1782

Query: 1687 GTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTE 1734
                 C +  +  I+F ++++ +  ++VN+ IAV++++   + +E+ E
Sbjct: 1783 -QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829



 Score =  149 bits (375), Expect = 3e-35
 Identities = 186/876 (21%), Positives = 350/876 (39%), Gaps = 168/876 (19%)

Query: 105  SATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCM---------TRTDLPEK 155
            S+  A W      LI  T  K+    +F   I + ILVN + M           T+  E 
Sbjct: 723  SSVLAFW-----RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEI 777

Query: 156  IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG--ISG 213
               VFT ++  E L+K+L  G     F Y+++P+N  D  VI +  V   +  +G  +S 
Sbjct: 778  SNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSV 832

Query: 214  LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLK 273
            LRTFR++R LK V  +P L+  +  L+ ++  +A   +L +  + +F+++G+ LF     
Sbjct: 833  LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---- 888

Query: 274  NKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPD 333
                           ++S R  D   +++                               
Sbjct: 889  -------------CKFASERDGDTLPDRK------------------------------- 904

Query: 334  FNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLIL 393
                +FDS  WA +++F+++TQ+ W ++    + ++     ++F+ ++  G++ L NL++
Sbjct: 905  ----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 394  AVVTMAYEEQNQATTDEIEAK----------EKKFQEALEMLRKEQEVLAALGIDTTSLH 443
            A++   ++ +  A   E E            ++K   AL  L +  E+  +L +    +H
Sbjct: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIH 1019

Query: 444  SHNGSPLTSKNAS----------ERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLA 493
            +        K+ S           RR         G+  + KSP S   +         +
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1079

Query: 494  SGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSP 553
               RR+S  S+   R+P      P G              R SLL G G   Q     S 
Sbjct: 1080 WTSRRSSRNSLG--RAPSLKRRSPSG-------------ERRSLLSGEGQESQDEEESSE 1124

Query: 554  LPQ--PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAM 611
              +  P+  D RH     +   +S   P  + V            ++E+ D     + A 
Sbjct: 1125 EERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQD--CNGKSAS 1182

Query: 612  SVVSIITSVLEELEESEQKCPPCLTSLSQKYLIW------DCC-----------PMWVKL 654
              ++      +   + +        S  ++   W       CC           P   + 
Sbjct: 1183 GRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRF 1242

Query: 655  KTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP--TFEAMLQIGNIVFTIFFTAEM 712
            + +   ++T    +  + + I +N I +AME   + P       L + N +FT  F AEM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 713  VFKIIA----FDPYYYFQKKWNIFDCIIVTVSLLEL--------GVAKKGSLSVLRSFRL 760
              K++A    F    Y +  WN+ D ++V +S++++        G    G L VLR  R 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 761  LRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLL--------GEN 812
            LR  ++      L  +++ + +S+  +GN+ +I      +F ++G QL         GE+
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422

Query: 813  YRN--NRKNISAPHEDWPRWHMHDF--FHSFLIVFRILCGE--WIENMWACME---VGQK 863
             RN  N+ + +     W R H ++F      L+   +L  +  W++ M+  ++   V Q+
Sbjct: 1423 TRNITNKSDCAEASYRWVR-HKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQ 1481

Query: 864  SI------CLILFLTVMVLGNLVVLNLFIALLLNSF 893
             I       L+ F++ +++    VLN+F+ +++ +F
Sbjct: 1482 PIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  128 bits (321), Expect = 6e-29
 Identities = 112/380 (29%), Positives = 171/380 (45%), Gaps = 95/380 (25%)

Query: 1142 RKTCYRIVEHSWFESFIIFMILLSSGSLAF----EDYYLDQKPTVKALLEYTDRVFTFIF 1197
            R  C R V + WFE   + +ILL+  +L      ED   D +   + L  + D +F F F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFAF-F 128

Query: 1198 VFEMLLKWVA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIKALRT 1251
              EM++K VA   +G K Y  + W  LDF IV        A +LEYS   +     A+RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RC 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    RC
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241

Query: 1311 INYTDGEFSLVPLSI----------------------VNNKSDCK--------------- 1333
              +    FSL PLS+                       N    C+               
Sbjct: 242  --FLPENFSL-PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPC 298

Query: 1334 -----IQNSTGSFFWVNVKVNFDNVAMG-----------------YLALLQVATFKGWMD 1371
                   NS+ +   VN    + N + G                 ++A+ QV T +GW+D
Sbjct: 299  GLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 1372 IMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ 1431
            IMY  +D+           + Y ++YF++ II G FF +NL + VI   F++ K++   +
Sbjct: 359  IMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---E 405

Query: 1432 DIFMTEEQKKYYNAMKKLGS 1451
               M E++ ++ +    L S
Sbjct: 406  SQLMREQRVRFLSNASTLAS 425



 Score =  118 bits (296), Expect = 5e-26
 Identities = 82/347 (23%), Positives = 158/347 (45%), Gaps = 49/347 (14%)

Query: 120 RRTAIKVSVHSWFSLFITVTILVNCVCM-------------TRTDLPEKIEYVFTVIYTF 166
           R   ++   + WF     + IL+NCV +              R  + +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGIS--GLRTFRVLRALK 224
           E ++K++A G    +  YL D WN LDF ++    +  ++DL+ +S   +RT RVLR L+
Sbjct: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKND---- 280
            ++ +P ++++V  L+ ++  L +V +L  F   +F +VG+QL+ G L+N+C   +    
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 281 -MAVNETTNYSSHRK---PDIYINKRGT------SDPLLCGNGSDSGHCPDGYICLKTSD 330
            ++V+    Y +  +   P I    R        S P L G+G     C   Y    +S 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS 309

Query: 331 -------------------NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK 371
                              NP     +FD+  +A++++F+++T + W  +    +     
Sbjct: 310 NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF 369

Query: 372 IYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKF 418
              I+F+L+I +GSF+++NL L V+   + E  Q  +  +  +  +F
Sbjct: 370 YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  108 bits (270), Expect = 5e-23
 Identities = 81/351 (23%), Positives = 151/351 (43%), Gaps = 67/351 (19%)

Query: 111  WLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCV--CMTRTDL-PEKIE--------YV 159
            ++F P +  R    ++  H  F   + V I +NC+   M R  + P   E        Y+
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 160  FTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG------ 213
            FT ++  E  +K++A G+C  E  YLR  WN LD  ++ ++ +   + +   SG      
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 214  ---LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKG 270
               LR  R LR L+ +S   GLK++V  L+ S+K + ++ ++      +F ++G+QLFKG
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 271  NLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSD 330
                                                  +C  G D+ +  +   C + S 
Sbjct: 1414 KF-----------------------------------FVC-QGEDTRNITNKSDCAEASY 1437

Query: 331  NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFVLV 380
                +  +FD+   A +SLF L ++D W  +           QQ +       +++F+  
Sbjct: 1438 RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISF 1497

Query: 381  IFLGSFYLVNLILAVVTMAYEEQNQ-ATTDEIEAKEKKFQEALEMLRKEQE 430
            + + +F+++N+ + VV   + +  Q    +E   +E+K    LE  R+ +E
Sbjct: 1498 LLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKE 1548



 Score =  103 bits (257), Expect = 2e-21
 Identities = 78/301 (25%), Positives = 144/301 (47%), Gaps = 36/301 (11%)

Query: 622  EELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIF 681
            +E + +E +C P  +  S             + + ++  L T  + +L IT  I +N + 
Sbjct: 1547 KEKQMAEAQCKPYYSDYS-------------RFRLLVHHLCTSHYLDLFITGVIGLNVVT 1593

Query: 682  MAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSL 741
            MAMEH+      +  L+I N +FT+ F  E VFK++AF    +FQ +WN  D  IV +S+
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653

Query: 742  LELGVAK----------KGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT 791
            + + + +             + ++R  R+ RV KL K    +  L+  +  ++  +GNL 
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713

Query: 792  IILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHDFFHSFLIVFRILCGE- 849
            ++  ++ F+FA +G +L G+   +     + P E   R     +F  +FL +FR+  G+ 
Sbjct: 1714 LLFMLLFFIFAALGVELFGDLECDE----THPCEGLGRHATFRNFGMAFLTLFRVSTGDN 1769

Query: 850  WIENMWACM-EVGQKSICL------ILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPE 902
            W   M   + +  Q+S C       I F++ ++    V++N+ IA+L+      N  A E
Sbjct: 1770 WNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829

Query: 903  D 903
            +
Sbjct: 1830 E 1830



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 109/472 (23%), Positives = 188/472 (39%), Gaps = 127/472 (26%)

Query: 113  FSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTD------LPEKIE---YVFTVI 163
            +S ++  R     +    +  LFIT  I +N V M          L E ++   Y+FTVI
Sbjct: 1560 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1619

Query: 164  YTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---------- 213
            +  E++ K++A GF      + +D WN LD +++ L+ +G  ++   ++           
Sbjct: 1620 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675

Query: 214  -LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
             +R  R+ R LK + +  G++ ++  ++ ++ ++ ++ +L +    +FA +G++LF    
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF---- 1731

Query: 273  KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332
                   D+  +ET                               H  +G          
Sbjct: 1732 ------GDLECDET-------------------------------HPCEGL--------- 1745

Query: 333  DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK--------IYMIFFVLVIFLG 384
               + +F +F  AFL+LFR+ T D+W  + + TLR   +        I  I+FV  +   
Sbjct: 1746 -GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804

Query: 385  SFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHS 444
             F LVN+++AV+    EE N+      EAKE            E E+ A L ++  +L  
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNK------EAKE------------EAELEAELELEMKTLSP 1846

Query: 445  HNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSV 504
               SPL S         + P V    + D+  P +          L  A+  R ASH S+
Sbjct: 1847 QPHSPLGSP-------FLWPGVEGPDSPDSPKPGA----------LHPAAHARSASHFSL 1889

Query: 505  FH-------FRSPGRDISL--PEGVTDDGVFPGDHESHRGSLLLGGGAGQQG 547
             H          PG D+      GV+     P D    R      G  G +G
Sbjct: 1890 EHPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRG 1941



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 68/275 (24%), Positives = 125/275 (45%), Gaps = 36/275 (13%)

Query: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531
            IV  + F   IM+ I +N ++M +E  +Q EE T  L   N  F ++F  E ++K+    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590
             + Y  N +N+FD ++VV+S+  ++                  V+R  R+ R+L+L+R  
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQ----------QGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SSFPHVRWEAGIDDMFNFQT 1646
              ++  L  LM ++  +    +LL L +FI+SI GM      F   R    + D  NF +
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1647 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYI 1706
               +++ +FQI T   W+ +L                      G   + +   ++F   +
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALM 948

Query: 1707 IISFLIMVNMYIAVILENFNVATEESTEPLSEDDF 1741
                 ++ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 949  TFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 68/281 (24%), Positives = 130/281 (46%), Gaps = 45/281 (16%)

Query: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
            T  +IV+  +F   I+  IL+++ S+  E  Y +Q   +   LE ++ VFT +F  EMLL
Sbjct: 735  TFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLL 792

Query: 1204 KWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSR 1263
            K + YG   Y  N +   D +IV IS+  +  +     +   +  LRT R +R L+ +  
Sbjct: 793  KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRF 847

Query: 1264 FEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPL 1323
               ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF    +  DG+      
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGD------ 898

Query: 1324 SIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVN 1383
            ++ + K                   NFD++    + + Q+ T + W  ++Y  + S    
Sbjct: 899  TLPDRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS---- 935

Query: 1384 MQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQ 1424
                   + +  LYF+  + FG +   NL V ++++ F  +
Sbjct: 936  ------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 49/157 (31%), Positives = 79/157 (50%), Gaps = 17/157 (10%)

Query: 1478 FDITIMVLICLNMITMMV----ETDDQSEEKTKILGKINQFFVAVFTGECVMKMFAL--- 1530
            F+   M++I LN +T+ +    E      ++ +IL   + F  A F  E V+KM AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1531 -RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589
             ++ Y  + WN  DF +V+  +  L +S  L+++        F  +R  R+ R LR I  
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGM--LEYSLDLQNVS-------FSAVRTVRVLRPLRAINR 193

Query: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626
               +R L+  L+ +LP L N+ LL F V FI+ I G+
Sbjct: 194  VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 58/209 (27%), Positives = 93/209 (44%), Gaps = 16/209 (7%)

Query: 626 ESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAM- 684
           E+E    P L  +   YL  D  P    L+T     V +P+ E    L I++N + + M 
Sbjct: 47  EAEGLPYPALAPVVFFYLSQDSRPRSWCLRT-----VCNPWFERISMLVILLNCVTLGMF 101

Query: 685 ---EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA---FDPYYYFQKKWNIFDCIIVT 738
              E          +LQ  +     FF  EMV K++A   F    Y    WN  D  IV 
Sbjct: 102 RPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI 161

Query: 739 VSLLELGVAKKG-SLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
             +LE  +  +  S S +R+ R+LR  +     P++  L+ ++ +++  LGN+ ++   +
Sbjct: 162 AGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 221

Query: 798 VFVFALVGKQLLGENYRNN---RKNISAP 823
            F+F +VG QL     RN     +N S P
Sbjct: 222 FFIFGIVGVQLWAGLLRNRCFLPENFSLP 250


>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
            isoform 13 [Homo sapiens]
          Length = 2243

 Score =  424 bits (1091), Expect = e-118
 Identities = 315/1122 (28%), Positives = 548/1122 (48%), Gaps = 106/1122 (9%)

Query: 671  ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWN 730
            I + I+VNT+ M +E+H         L+I NIVFT  F  EM+ K++ + P+ Y +  +N
Sbjct: 749  IMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808

Query: 731  IFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 790
            IFD +IV +S+ E+   + G LSVLR+FRL+RV KL +  P L   + ++  ++  +   
Sbjct: 809  IFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868

Query: 791  TIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGE- 849
             ++L + +F+F+++G  L G  + + R   + P     R +      + + VF+IL  E 
Sbjct: 869  CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPD----RKNFDSLLWAIVTVFQILTQED 924

Query: 850  WIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSAD----------NLT 899
            W + ++  M     S   + F+ +M  GN V+ NL +A+L+  F A+          +  
Sbjct: 925  WNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFF 983

Query: 900  APEDDGEVNNLQVALARIQVFGH-RTKQALCS---FFSRSCPFPQPKAEPELVVKLPLSS 955
            +P  DG+  + +  LA + +  H   +++L       + + P   PK+    + +  L  
Sbjct: 984  SPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEA-LGP 1041

Query: 956  SKAENHIAANTARGSSGGLQAPRGPRDE-HSDFIANPTVWVSVPIAE---GESDLDDLED 1011
            +      + +   G++  +++P   R   HS + A  + W S   +    G +       
Sbjct: 1042 ASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS-WTSRRSSRNSLGRAPSLKRRS 1100

Query: 1012 DGGEDAQSFQQEVIPKGQQEQLQQVERCG----DHLTPRS-PGTGTSSEDLAPSLGETWK 1066
              GE       E      +E+  + ER      DH    S      SS DL  +L     
Sbjct: 1101 PSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTL----- 1155

Query: 1067 DESVPQVPAEGVDDTSSSEGSTV---DCLDPEEILRKIPELADDLE--EPDDCFTEGCIR 1121
                 QVP  G+  T+S  GS     DC       R    L  D    + DD   EG + 
Sbjct: 1156 -----QVP--GLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLS 1208

Query: 1122 -----------HCPCCKLDTTKSPWDV-----GWQVRKTCYRIVEHSWFESFIIFMILLS 1165
                         P C L+  +  W         + R  C+RI+ H  F+  ++ +I L+
Sbjct: 1209 KGERVRAWIRARLPACCLE--RDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLN 1266

Query: 1166 SGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGF----KKYFTNAWCWL 1221
              ++A E   +D     +  L  ++ +FT +F+ EM +K VA G+    + Y  ++W  L
Sbjct: 1267 CITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVL 1326

Query: 1222 DFLIVNISLISLTAKILEYSE---VAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAI 1278
            D L+V IS+I +   ++  S    +  ++ LR LR LRPLR +SR +G+++VV+ L+ ++
Sbjct: 1327 DGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSL 1386

Query: 1279 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNST 1338
              I N++++C  F++IF I+GV LF GKF+ C     GE +      + NKSDC    + 
Sbjct: 1387 KPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDT----RNITNKSDC----AE 1434

Query: 1339 GSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYF 1398
             S+ WV  K NFDN+    ++L  +A+  GW+DIMY  +D+  V+ QP    N +M LYF
Sbjct: 1435 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1494

Query: 1399 VIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1458
            + F++   FF LN+FVGV+++NF++ ++    ++    EE  K    ++K   K   KP 
Sbjct: 1495 ISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE--KRLRRLEKKRRKAQCKPY 1552

Query: 1459 PRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAV 1518
                ++F+  V  + T    D+ I  +I LN++TM +E   Q +   + L   N  F  +
Sbjct: 1553 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1612

Query: 1519 FTGECVMKMFALR-QYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRL 1577
            F  E V K+ A   + +F + WN  D  +V+LSI  +    I  +     +PT+ R++R+
Sbjct: 1613 FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV 1672

Query: 1578 ARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWE-- 1635
             RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  F  +  +  
Sbjct: 1673 LRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDET 1732

Query: 1636 ---AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDC 1692
                G+     F+ F  + L LF+++T   W+G++   L      CD            C
Sbjct: 1733 HPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD--------QESTC 1780

Query: 1693 GSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTE 1734
             +  +  I+F ++++ +  ++VN+ IAV++++   + +E+ E
Sbjct: 1781 YNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1822



 Score =  149 bits (375), Expect = 3e-35
 Identities = 186/876 (21%), Positives = 350/876 (39%), Gaps = 168/876 (19%)

Query: 105  SATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCM---------TRTDLPEK 155
            S+  A W      LI  T  K+    +F   I + ILVN + M           T+  E 
Sbjct: 723  SSVLAFW-----RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEI 777

Query: 156  IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG--ISG 213
               VFT ++  E L+K+L  G     F Y+++P+N  D  VI +  V   +  +G  +S 
Sbjct: 778  SNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSV 832

Query: 214  LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLK 273
            LRTFR++R LK V  +P L+  +  L+ ++  +A   +L +  + +F+++G+ LF     
Sbjct: 833  LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---- 888

Query: 274  NKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPD 333
                           ++S R  D   +++                               
Sbjct: 889  -------------CKFASERDGDTLPDRK------------------------------- 904

Query: 334  FNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLIL 393
                +FDS  WA +++F+++TQ+ W ++    + ++     ++F+ ++  G++ L NL++
Sbjct: 905  ----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 394  AVVTMAYEEQNQATTDEIEAK----------EKKFQEALEMLRKEQEVLAALGIDTTSLH 443
            A++   ++ +  A   E E            ++K   AL  L +  E+  +L +    +H
Sbjct: 961  AILVEGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIH 1019

Query: 444  SHNGSPLTSKNAS----------ERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLA 493
            +        K+ S           RR         G+  + KSP S   +         +
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1079

Query: 494  SGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSP 553
               RR+S  S+   R+P      P G              R SLL G G   Q     S 
Sbjct: 1080 WTSRRSSRNSLG--RAPSLKRRSPSG-------------ERRSLLSGEGQESQDEEESSE 1124

Query: 554  LPQ--PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAM 611
              +  P+  D RH     +   +S   P  + V            ++E+ D     + A 
Sbjct: 1125 EERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQD--CNGKSAS 1182

Query: 612  SVVSIITSVLEELEESEQKCPPCLTSLSQKYLIW------DCC-----------PMWVKL 654
              ++      +   + +        S  ++   W       CC           P   + 
Sbjct: 1183 GRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRF 1242

Query: 655  KTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP--TFEAMLQIGNIVFTIFFTAEM 712
            + +   ++T    +  + + I +N I +AME   + P       L + N +FT  F AEM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 713  VFKIIA----FDPYYYFQKKWNIFDCIIVTVSLLEL--------GVAKKGSLSVLRSFRL 760
              K++A    F    Y +  WN+ D ++V +S++++        G    G L VLR  R 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 761  LRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLL--------GEN 812
            LR  ++      L  +++ + +S+  +GN+ +I      +F ++G QL         GE+
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422

Query: 813  YRN--NRKNISAPHEDWPRWHMHDF--FHSFLIVFRILCGE--WIENMWACME---VGQK 863
             RN  N+ + +     W R H ++F      L+   +L  +  W++ M+  ++   V Q+
Sbjct: 1423 TRNITNKSDCAEASYRWVR-HKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQ 1481

Query: 864  SI------CLILFLTVMVLGNLVVLNLFIALLLNSF 893
             I       L+ F++ +++    VLN+F+ +++ +F
Sbjct: 1482 PIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  128 bits (321), Expect = 6e-29
 Identities = 112/380 (29%), Positives = 171/380 (45%), Gaps = 95/380 (25%)

Query: 1142 RKTCYRIVEHSWFESFIIFMILLSSGSLAF----EDYYLDQKPTVKALLEYTDRVFTFIF 1197
            R  C R V + WFE   + +ILL+  +L      ED   D +   + L  + D +F F F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFAF-F 128

Query: 1198 VFEMLLKWVA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIKALRT 1251
              EM++K VA   +G K Y  + W  LDF IV        A +LEYS   +     A+RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RC 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    RC
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241

Query: 1311 INYTDGEFSLVPLSI----------------------VNNKSDCK--------------- 1333
              +    FSL PLS+                       N    C+               
Sbjct: 242  --FLPENFSL-PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPC 298

Query: 1334 -----IQNSTGSFFWVNVKVNFDNVAMG-----------------YLALLQVATFKGWMD 1371
                   NS+ +   VN    + N + G                 ++A+ QV T +GW+D
Sbjct: 299  GLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 1372 IMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ 1431
            IMY  +D+           + Y ++YF++ II G FF +NL + VI   F++ K++   +
Sbjct: 359  IMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---E 405

Query: 1432 DIFMTEEQKKYYNAMKKLGS 1451
               M E++ ++ +    L S
Sbjct: 406  SQLMREQRVRFLSNASTLAS 425



 Score =  118 bits (296), Expect = 5e-26
 Identities = 82/347 (23%), Positives = 158/347 (45%), Gaps = 49/347 (14%)

Query: 120 RRTAIKVSVHSWFSLFITVTILVNCVCM-------------TRTDLPEKIEYVFTVIYTF 166
           R   ++   + WF     + IL+NCV +              R  + +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGIS--GLRTFRVLRALK 224
           E ++K++A G    +  YL D WN LDF ++    +  ++DL+ +S   +RT RVLR L+
Sbjct: 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKND---- 280
            ++ +P ++++V  L+ ++  L +V +L  F   +F +VG+QL+ G L+N+C   +    
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 281 -MAVNETTNYSSHRK---PDIYINKRGT------SDPLLCGNGSDSGHCPDGYICLKTSD 330
            ++V+    Y +  +   P I    R        S P L G+G     C   Y    +S 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS 309

Query: 331 -------------------NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK 371
                              NP     +FD+  +A++++F+++T + W  +    +     
Sbjct: 310 NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF 369

Query: 372 IYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKF 418
              I+F+L+I +GSF+++NL L V+   + E  Q  +  +  +  +F
Sbjct: 370 YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  107 bits (266), Expect = 1e-22
 Identities = 80/351 (22%), Positives = 151/351 (43%), Gaps = 68/351 (19%)

Query: 111  WLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCV--CMTRTDL-PEKIE--------YV 159
            ++F P +  R    ++  H  F   + V I +NC+   M R  + P   E        Y+
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 160  FTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG------ 213
            FT ++  E  +K++A G+C  E  YLR  WN LD  ++ ++ +   + +   SG      
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 214  ---LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKG 270
               LR  R LR L+ +S   GLK++V  L+ S+K + ++ ++      +F ++G+QLFKG
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 271  NLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSD 330
                                                  +C  G D+ +  +   C + S 
Sbjct: 1414 KF-----------------------------------FVC-QGEDTRNITNKSDCAEASY 1437

Query: 331  NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFVLV 380
                +  +FD+   A +SLF L ++D W  +           QQ +       +++F+  
Sbjct: 1438 RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISF 1497

Query: 381  IFLGSFYLVNLILAVVTMAYEE--QNQATTDEIEAKEKKFQEALEMLRKEQ 429
            + + +F+++N+ + VV   + +  Q+Q   +    +EK+ +   +  RK Q
Sbjct: 1498 LLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRKAQ 1548



 Score =  106 bits (264), Expect = 3e-22
 Identities = 81/304 (26%), Positives = 148/304 (48%), Gaps = 26/304 (8%)

Query: 622  EELEESEQKCPPCLTSLSQKYLIWDCCPMWV---KLKTILFGLVTDPFAELTITLCIVVN 678
            +E EE+ ++    L  L +K     C P +    + + ++  L T  + +L IT  I +N
Sbjct: 1524 QEEEEARRREEKRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1583

Query: 679  TIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVT 738
             + MAMEH+      +  L+I N +FT+ F  E VFK++AF    +FQ +WN  D  IV 
Sbjct: 1584 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1643

Query: 739  VSLLELGVAK----------KGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 788
            +S++ + + +             + ++R  R+ RV KL K    +  L+  +  ++  +G
Sbjct: 1644 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1703

Query: 789  NLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHDFFHSFLIVFRILC 847
            NL ++  ++ F+FA +G +L G+   +     + P E   R     +F  +FL +FR+  
Sbjct: 1704 NLGLLFMLLFFIFAALGVELFGDLECDE----THPCEGLGRHATFRNFGMAFLTLFRVST 1759

Query: 848  GE-WIENMWACM-EVGQKSICL------ILFLTVMVLGNLVVLNLFIALLLNSFSADNLT 899
            G+ W   M   + +  Q+S C       I F++ ++    V++N+ IA+L+      N  
Sbjct: 1760 GDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1819

Query: 900  APED 903
            A E+
Sbjct: 1820 AKEE 1823



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 109/472 (23%), Positives = 188/472 (39%), Gaps = 127/472 (26%)

Query: 113  FSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTD------LPEKIE---YVFTVI 163
            +S ++  R     +    +  LFIT  I +N V M          L E ++   Y+FTVI
Sbjct: 1553 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1612

Query: 164  YTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---------- 213
            +  E++ K++A GF      + +D WN LD +++ L+ +G  ++   ++           
Sbjct: 1613 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1668

Query: 214  -LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
             +R  R+ R LK + +  G++ ++  ++ ++ ++ ++ +L +    +FA +G++LF    
Sbjct: 1669 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF---- 1724

Query: 273  KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332
                   D+  +ET                               H  +G          
Sbjct: 1725 ------GDLECDET-------------------------------HPCEGL--------- 1738

Query: 333  DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK--------IYMIFFVLVIFLG 384
               + +F +F  AFL+LFR+ T D+W  + + TLR   +        I  I+FV  +   
Sbjct: 1739 -GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1797

Query: 385  SFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHS 444
             F LVN+++AV+    EE N+      EAKE            E E+ A L ++  +L  
Sbjct: 1798 QFVLVNVVIAVLMKHLEESNK------EAKE------------EAELEAELELEMKTLSP 1839

Query: 445  HNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSV 504
               SPL S         + P V    + D+  P +          L  A+  R ASH S+
Sbjct: 1840 QPHSPLGSP-------FLWPGVEGPDSPDSPKPGA----------LHPAAHARSASHFSL 1882

Query: 505  FH-------FRSPGRDISL--PEGVTDDGVFPGDHESHRGSLLLGGGAGQQG 547
             H          PG D+      GV+     P D    R      G  G +G
Sbjct: 1883 EHPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRG 1934



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 68/275 (24%), Positives = 125/275 (45%), Gaps = 36/275 (13%)

Query: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531
            IV  + F   IM+ I +N ++M +E  +Q EE T  L   N  F ++F  E ++K+    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590
             + Y  N +N+FD ++VV+S+  ++                  V+R  R+ R+L+L+R  
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQ----------QGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SSFPHVRWEAGIDDMFNFQT 1646
              ++  L  LM ++  +    +LL L +FI+SI GM      F   R    + D  NF +
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1647 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYI 1706
               +++ +FQI T   W+ +L                      G   + +   ++F   +
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALM 948

Query: 1707 IISFLIMVNMYIAVILENFNVATEESTEPLSEDDF 1741
                 ++ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 949  TFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 68/281 (24%), Positives = 130/281 (46%), Gaps = 45/281 (16%)

Query: 1144 TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLL 1203
            T  +IV+  +F   I+  IL+++ S+  E  Y +Q   +   LE ++ VFT +F  EMLL
Sbjct: 735  TFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLL 792

Query: 1204 KWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSR 1263
            K + YG   Y  N +   D +IV IS+  +  +     +   +  LRT R +R L+ +  
Sbjct: 793  KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRF 847

Query: 1264 FEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPL 1323
               ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF    +  DG+      
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---ASERDGD------ 898

Query: 1324 SIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVN 1383
            ++ + K                   NFD++    + + Q+ T + W  ++Y  + S    
Sbjct: 899  TLPDRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS---- 935

Query: 1384 MQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQ 1424
                   + +  LYF+  + FG +   NL V ++++ F  +
Sbjct: 936  ------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 49/157 (31%), Positives = 79/157 (50%), Gaps = 17/157 (10%)

Query: 1478 FDITIMVLICLNMITMMV----ETDDQSEEKTKILGKINQFFVAVFTGECVMKMFAL--- 1530
            F+   M++I LN +T+ +    E      ++ +IL   + F  A F  E V+KM AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1531 -RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589
             ++ Y  + WN  DF +V+  +  L +S  L+++        F  +R  R+ R LR I  
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGM--LEYSLDLQNVS-------FSAVRTVRVLRPLRAINR 193

Query: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626
               +R L+  L+ +LP L N+ LL F V FI+ I G+
Sbjct: 194  VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 58/209 (27%), Positives = 93/209 (44%), Gaps = 16/209 (7%)

Query: 626 ESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAM- 684
           E+E    P L  +   YL  D  P    L+T     V +P+ E    L I++N + + M 
Sbjct: 47  EAEGLPYPALAPVVFFYLSQDSRPRSWCLRT-----VCNPWFERISMLVILLNCVTLGMF 101

Query: 685 ---EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA---FDPYYYFQKKWNIFDCIIVT 738
              E          +LQ  +     FF  EMV K++A   F    Y    WN  D  IV 
Sbjct: 102 RPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI 161

Query: 739 VSLLELGVAKKG-SLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAII 797
             +LE  +  +  S S +R+ R+LR  +     P++  L+ ++ +++  LGN+ ++   +
Sbjct: 162 AGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 221

Query: 798 VFVFALVGKQLLGENYRNN---RKNISAP 823
            F+F +VG QL     RN     +N S P
Sbjct: 222 FFIFGIVGVQLWAGLLRNRCFLPENFSLP 250


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score =  423 bits (1087), Expect = e-118
 Identities = 306/1157 (26%), Positives = 531/1157 (45%), Gaps = 130/1157 (11%)

Query: 650  MWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFT 709
            +WV     L  +V   +    I + I+VNT+ M +E+H         L+I NIVFT  F 
Sbjct: 778  LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFA 837

Query: 710  AEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKS 769
             EM+ K++A  P  Y +  +NIFD IIV +S+ E+     G LSVLR+FRLLRV KL + 
Sbjct: 838  LEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRF 897

Query: 770  WPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPR 829
             P L   + ++  ++  +     +L + +F+F+++G  L G  +           +   R
Sbjct: 898  LPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPD---R 954

Query: 830  WHMHDFFHSFLIVFRILCGE-WIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIAL 888
             +      + + VF+IL  E W   ++  M     S   + F+ +M  GN V+ NL +A+
Sbjct: 955  KNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAI 1013

Query: 889  LLNSFSADNLTAPEDDGE------------------VNNLQVALARIQVFGHRTKQALCS 930
            L+  F A+      D  E                     L++    +   GH   +   S
Sbjct: 1014 LVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLS 1073

Query: 931  ----FFSRSCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPRGPRDEHSD 986
                  + + P P PK+ P L     L  S+          RGSS     P G +   + 
Sbjct: 1074 PPLIMCTAATPMPTPKSSPFLDAAPSLPDSR----------RGSSSSGDPPLGDQKPPAS 1123

Query: 987  FIANPTV-WVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPK-GQQEQLQQVERCGDHLT 1044
              ++P   W                  G   A S ++      G+   L++  +CG+  +
Sbjct: 1124 LRSSPCAPW------------------GPSGAWSSRRSSWSSLGRAPSLKRRGQCGERES 1165

Query: 1045 PRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGST--VDCLD--------P 1094
              S     S++D A          + P   AE +D       +     C D        P
Sbjct: 1166 LLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALP 1225

Query: 1095 EEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGW--------------- 1139
             +   +I    +D  E DD   + C     C +L     P+   W               
Sbjct: 1226 SDFFLRIDSHREDAAELDDDSEDSC-----CLRLHKVLEPYKPQWCRSREAWALYLFSPQ 1280

Query: 1140 -QVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFV 1198
             + R +C +++ H  F+  ++  I L+  ++A E   +D   T +  L  ++ +FT IFV
Sbjct: 1281 NRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFV 1340

Query: 1199 FEMLLKWVAYGFKK----YFTNAWCWLDFLIVNISLISLTAKILEYSE---VAPIKALRT 1251
             EM++K VA G       Y  ++W  LD L+V +SL+ +   +        +  ++ LR 
Sbjct: 1341 AEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRL 1400

Query: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCI 1311
            LR LRPLR +SR  G+++VV+ L+ ++  I N++L+C  F++IF I+GV LF GKF+ C 
Sbjct: 1401 LRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCE 1460

Query: 1312 NYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMD 1371
                   S         K+ C+  +    + WV  K NFDN+    ++L  +++  GW++
Sbjct: 1461 GPDTRNIS--------TKAQCRAAH----YRWVRRKYNFDNLGQALMSLFVLSSKDGWVN 1508

Query: 1372 IMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ 1431
            IMY  +D+  V+ QP    N +M LYF+ F++   FF LN+FVGV+++NF++ ++    +
Sbjct: 1509 IMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE 1568

Query: 1432 DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMI 1491
            +    EE  K    +++   K  ++P     +  +  +  + T    D+ I  +IC+N+I
Sbjct: 1569 EARRREE--KRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVI 1626

Query: 1492 TMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVVLS 1550
            TM +E  +Q +   + L   N  F  VF  E  +K+ A   + +F + WN  D  +V+LS
Sbjct: 1627 TMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLS 1686

Query: 1551 IASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNI 1610
            +  +    I  S     +PT+ R++R+ RI R+L+L++ A G+R LL  ++ +LP + N+
Sbjct: 1687 LMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNL 1746

Query: 1611 GLLLFLVMFIYSIFGMSSFPHVRWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDG 1665
            GLL  L+ FIY+  G+  F  +         G+     F  F  + L LF+++T   W+G
Sbjct: 1747 GLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNG 1806

Query: 1666 LLSPIL---NTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVIL 1722
            ++   L   +    +C   L            PA+  ++F T+++++  ++VN+ +AV++
Sbjct: 1807 IMKDTLRECSREDKHCLSYL------------PALSPVYFVTFVLVAQFVLVNVVVAVLM 1854

Query: 1723 ENFNVATEESTEPLSED 1739
            ++   + +E+ E    D
Sbjct: 1855 KHLEESNKEAREDAELD 1871



 Score =  144 bits (364), Expect = 6e-34
 Identities = 197/861 (22%), Positives = 353/861 (40%), Gaps = 194/861 (22%)

Query: 131  WFSLFITVTILVNCVCM---------TRTDLPEKIEYVFTVIYTFEALIKILARGFCLNE 181
            +FS  I + ILVN + M           T+  E    VFT ++  E L+K+LA G     
Sbjct: 794  YFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG----P 849

Query: 182  FTYLRDPWNWLDFSVITLAY---VGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGA 238
              Y+R+P+N  D  ++ ++    VG A    G+S LRTFR+LR LK V  +P L+  +  
Sbjct: 850  LGYIRNPYNIFDGIIVVISVWEIVGQADG--GLSVLRTFRLLRVLKLVRFLPALRRQLVV 907

Query: 239  LIHSVKKLADVTILTIFCLSVFALVGLQLF--KGNLKNKCVKNDMAVNETTNYSSHRKPD 296
            L+ ++  +A    L +  + +F+++G+ LF  K +LK                       
Sbjct: 908  LVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLK----------------------- 944

Query: 297  IYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQD 356
                             +D+G            D  +F+     S  WA +++F+++TQ+
Sbjct: 945  -----------------TDTGD--------TVPDRKNFD-----SLLWAIVTVFQILTQE 974

Query: 357  SWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYE---EQNQATTDEIEA 413
             W  +    + ++     ++FV ++  G++ L NL++A++   ++   + N++ TDE + 
Sbjct: 975  DWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDE-DK 1033

Query: 414  KEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTED 473
                F+E    LR+         + TT L   + +   + +   R     P +   +   
Sbjct: 1034 TSVHFEEDFHKLRE---------LQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATP 1084

Query: 474  NKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFP----GD 529
              +P+S P       FL  A     +  GS      P  D   P  +      P    G 
Sbjct: 1085 MPTPKSSP-------FLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGA 1137

Query: 530  HESHRGSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDA 589
              S R S            L R+P  +      R G+   +    S    G+ D  A D 
Sbjct: 1138 WSSRRSS---------WSSLGRAPSLK------RRGQCGERESLLSGEGKGSTDDEAEDG 1182

Query: 590  ----GQKKTFL-SAEYLD-EPFR---------AQRAMSVVSI-------ITSVLEEL--- 624
                G + T L  AE LD  P R           R   VV++       I S  E+    
Sbjct: 1183 RAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAEL 1242

Query: 625  -EESEQKCPPCLTSLSQKYLIWDCCPMWVKLK----TILFG-----------LVTDPFAE 668
             ++SE  C   L  + + Y      P W + +      LF            ++T    +
Sbjct: 1243 DDDSEDSCCLRLHKVLEPYK-----PQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFD 1297

Query: 669  LTITLCIVVNTIFMAMEHHGMSP--TFEAMLQIGNIVFTIFFTAEMVFKIIAF----DPY 722
              + + I +N + +A+E   + P  T    L + N +FT  F AEM+ K++A       +
Sbjct: 1298 HVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEH 1357

Query: 723  YYFQKKWNIFDCIIVTVSLLELGVAKK--------GSLSVLRSFRLLRVFKLAKSWPTLN 774
             Y Q  WN+ D ++V VSL+++ VA          G L VLR  R LR  ++    P L 
Sbjct: 1358 AYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLK 1417

Query: 775  TLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLL--------GENYRN--NRKNISAPH 824
             +++ + +S+  +GN+ +I      +F ++G QL         G + RN   +    A H
Sbjct: 1418 LVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAH 1477

Query: 825  EDWPR--WHMHDFFHSFLIVFRILCGE-WIENMWACME---VGQKSI------CLILFLT 872
              W R  ++  +   + + +F +   + W+  M+  ++   V Q+ +       L+ F++
Sbjct: 1478 YRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFIS 1537

Query: 873  VMVLGNLVVLNLFIALLLNSF 893
             +++ +  VLN+F+ +++ +F
Sbjct: 1538 FLLIVSFFVLNMFVGVVVENF 1558



 Score =  125 bits (313), Expect = 5e-28
 Identities = 81/342 (23%), Positives = 155/342 (45%), Gaps = 60/342 (17%)

Query: 120 RRTAIKVSVHSWFSLFITVTILVNCVCM-------------TRTDLPEKIEYVFTVIYTF 166
           R   +++  + WF     + I++NCV +              R ++ E  +      +  
Sbjct: 90  RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAV 149

Query: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGIS--GLRTFRVLRALK 224
           E +IK++A G    +  YL D WN LDF ++    +  ++D   +S   +RT RVLR L+
Sbjct: 150 EMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLR 208

Query: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVN 284
            ++ +P ++++V  L+ ++  L +V +L  F   +F +VG+QL+ G L+N+C  +   V 
Sbjct: 209 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVR 268

Query: 285 ETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSG-----HCP-------------DGY--- 323
              N  +  +P  Y  + G  +P +C +  D+G     H P             + Y   
Sbjct: 269 --NNNLTFLRP-YYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYTQP 325

Query: 324 --------------------ICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQ 363
                               +C     NP     +FD+  +A++++F+++T + W  +  
Sbjct: 326 QAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMY 385

Query: 364 QTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQ 405
             +        I+F+L+I +GSF+++NL L V+   + E  Q
Sbjct: 386 YVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQ 427



 Score =  114 bits (284), Expect = 1e-24
 Identities = 91/353 (25%), Positives = 157/353 (44%), Gaps = 67/353 (18%)

Query: 109  ALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCV--CMTRTDLP----EKI-----E 157
            AL+LFSP N  R +  KV  H  F   + V I +NCV   + R D+     E++      
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332

Query: 158  YVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---- 213
            Y+FT I+  E ++K++A G    E  YL+  WN LD  ++ ++ V   + +    G    
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392

Query: 214  -----LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLF 268
                 LR  R LR L+ +S  PGLK++V  LI S++ + ++ ++      +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452

Query: 269  KGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKT 328
            KG                  +     PD     R  S    C     + H    Y  ++ 
Sbjct: 1453 KG-----------------KFYYCEGPD----TRNISTKAQC----RAAH----YRWVRR 1483

Query: 329  SDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFV 378
              N       FD+   A +SLF L ++D W  +           QQ ++      +++F+
Sbjct: 1484 KYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFI 1536

Query: 379  LVIFLGSFYLVNLILAVVTMAYEEQNQ-ATTDEIEAKEKKFQEALEMLRKEQE 430
              + + SF+++N+ + VV   + +  Q    +E   +E+K    LE  R++ +
Sbjct: 1537 SFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRKAQ 1589



 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 72/331 (21%), Positives = 147/331 (44%), Gaps = 86/331 (25%)

Query: 113  FSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRT--DLPEKIE-------YVFTVI 163
            ++ ++  RR+   +    +  LFIT  I VN + M+    + P+ ++       YVFT++
Sbjct: 1594 YADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIV 1653

Query: 164  YTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---------- 213
            + FEA +K++A GF      + +D WN LD +++ L+ +G  ++   +S           
Sbjct: 1654 FVFEAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIR 1709

Query: 214  -LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
             +R  R+ R LK + +  G++ ++  ++ ++ ++ ++ +L +    ++A +G++LF G L
Sbjct: 1710 IMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GRL 1768

Query: 273  KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332
            +                                             C +   C   S   
Sbjct: 1769 E---------------------------------------------CSEDNPCEGLS--- 1780

Query: 333  DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK-----------IYMIFFVLVI 381
               + +F +F  AFL+LFR+ T D+W  + + TLR   +           +  ++FV  +
Sbjct: 1781 --RHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFV 1838

Query: 382  FLGSFYLVNLILAVVTMAYEEQNQATTDEIE 412
             +  F LVN+++AV+    EE N+   ++ E
Sbjct: 1839 LVAQFVLVNVVVAVLMKHLEESNKEAREDAE 1869



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 63/174 (36%), Positives = 92/174 (52%), Gaps = 19/174 (10%)

Query: 1142 RKTCYRIVEHSWFESFIIFMILLSSGSLAF----EDYYLDQKPTVKALLEYTDRVFTFIF 1197
            R  C R+V + WFE   + +I+L+  +L      ED     +     +LE  D      F
Sbjct: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147

Query: 1198 VFEMLLKWVA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIKALRT 1251
              EM++K VA   +G K Y  + W  LDF IV        A ++EYS       + A+RT
Sbjct: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAIRT 200

Query: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1305
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 201  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254



 Score = 92.0 bits (227), Expect = 5e-18
 Identities = 72/288 (25%), Positives = 130/288 (45%), Gaps = 36/288 (12%)

Query: 1465 FQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECV 1524
            F G +  IV  + F   IM+ I +N ++M VE  +Q EE T  L   N  F ++F  E +
Sbjct: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841

Query: 1525 MKMFALRQY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRI 1583
            +K+ A     Y  N +N+FD I+VV+S+  ++  A               V+R  R+ R+
Sbjct: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA----------DGGLSVLRTFRLLRV 891

Query: 1584 LRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFP---HVRWEAG--I 1638
            L+L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     ++ + G  +
Sbjct: 892  LKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTV 951

Query: 1639 DDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVG 1698
             D  NF +   +++ +FQI T   W+ +L                      G   + +  
Sbjct: 952  PDRKNFDSLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSWA 991

Query: 1699 IIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYE 1746
             ++F   +     ++ N+ +A+++E F    + +     ED   + +E
Sbjct: 992  ALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 76/298 (25%), Positives = 131/298 (43%), Gaps = 50/298 (16%)

Query: 1133 SPWDVGWQVRK------TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALL 1186
            +P + GW  R          RIV+  +F   I+  IL+++ S+  E  Y +Q   +   L
Sbjct: 768  APGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNAL 825

Query: 1187 EYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPI 1246
            E ++ VFT +F  EMLLK +A G   Y  N +   D +IV IS+  +  +         +
Sbjct: 826  EISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA-----DGGL 880

Query: 1247 KALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1306
              LRT R LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  K
Sbjct: 881  SVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCK 940

Query: 1307 FWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATF 1366
            F                          ++  TG    V  + NFD++    + + Q+ T 
Sbjct: 941  F-------------------------SLKTDTGD--TVPDRKNFDSLLWAIVTVFQILTQ 973

Query: 1367 KGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQ 1424
            + W  ++Y  + S           + +  LYFV  + FG +   NL V ++++ F  +
Sbjct: 974  EDWNVVLYNGMAS----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 40/133 (30%), Positives = 70/133 (52%), Gaps = 13/133 (9%)

Query: 1345 NVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIF 1404
            N  +NFDN+   ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II 
Sbjct: 356  NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAH----------SFYNFIYFILLIIV 405

Query: 1405 GGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1464
            G FF +NL + VI   F++ K++   +   M E++ ++ +    L S          L K
Sbjct: 406  GSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLK 462

Query: 1465 FQGFVFDIVTRQA 1477
            + G +F  V R++
Sbjct: 463  YVGHIFRKVKRRS 475



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 51/163 (31%), Positives = 76/163 (46%), Gaps = 17/163 (10%)

Query: 1472 IVTRQAFDITIMVLICLNMITMMV----ETDDQSEEKTKILGKINQFFVAVFTGECVMKM 1527
            +V    F+   M++I LN +T+ +    E  +   E+  IL   + F  A F  E V+KM
Sbjct: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 1528 FAL----RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRI 1583
             AL    ++ Y  + WN  DF +VV  +          SL +         IR  R+ R 
Sbjct: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSA---------IRTVRVLRP 206

Query: 1584 LRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626
            LR I     +R L+  L+ +LP L N+ LL F V FI+ I G+
Sbjct: 207  LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 249



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 52/206 (25%), Positives = 92/206 (44%), Gaps = 28/206 (13%)

Query: 626 ESEQKCP-PCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAM 684
           + EQ+ P P L +      ++ C     + ++    LV +P+ E    L I++N + + M
Sbjct: 65  DEEQRVPYPALAAT-----VFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGM 119

Query: 685 -----------EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA---FDPYYYFQKKWN 730
                      E   +   F+A +         FF  EMV K++A   F    Y    WN
Sbjct: 120 FRPCEDVECGSERCNILEAFDAFI-------FAFFAVEMVIKMVALGLFGQKCYLGDTWN 172

Query: 731 IFDCIIVTVSLLELGV-AKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGN 789
             D  IV   ++E  +     SLS +R+ R+LR  +     P++  L+ ++ +++  LGN
Sbjct: 173 RLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGN 232

Query: 790 LTIILAIIVFVFALVGKQLLGENYRN 815
           + ++   + F+F +VG QL     RN
Sbjct: 233 VLLLCFFVFFIFGIVGVQLWAGLLRN 258


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,476,205
Number of Sequences: 37866
Number of extensions: 3501765
Number of successful extensions: 17857
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 114
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 13327
Number of HSP's gapped (non-prelim): 1642
length of query: 1956
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1839
effective length of database: 13,817,196
effective search space: 25409823444
effective search space used: 25409823444
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.