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Search of human proteins with 110832839
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110832839 ATP-binding cassette, sub-family C, member 9
isoform SUR2A-delta-14 [Homo sapiens]
(1513 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 2996 0.0
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 2978 0.0
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 2927 0.0
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 2060 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 768 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 753 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 726 0.0
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 682 0.0
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 678 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 665 0.0
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 631 e-180
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 611 e-174
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 609 e-174
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 558 e-158
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 558 e-158
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 553 e-157
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 553 e-157
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 502 e-141
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 495 e-139
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 446 e-125
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 365 e-100
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 285 3e-76
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 224 6e-58
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 214 7e-55
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 207 8e-53
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 199 2e-50
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 190 1e-47
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 161 5e-39
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 159 3e-38
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 150 1e-35
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 2996 bits (7767), Expect = 0.0
Identities = 1513/1513 (100%), Positives = 1513/1513 (100%)
Query: 1 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH 60
MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH
Sbjct: 1 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH 60
Query: 61 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV 120
NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV
Sbjct: 61 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV 120
Query: 121 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL 180
YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL
Sbjct: 121 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL 180
Query: 181 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK 240
MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK
Sbjct: 181 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK 240
Query: 241 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS 300
KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS
Sbjct: 241 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS 300
Query: 301 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL 360
STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL
Sbjct: 301 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL 360
Query: 361 ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE 420
ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE
Sbjct: 361 ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE 420
Query: 421 TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA 480
TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA
Sbjct: 421 TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA 480
Query: 481 QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI 540
QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI
Sbjct: 481 QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI 540
Query: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII 600
FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII
Sbjct: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII 600
Query: 601 SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLATLSNIDIRIP 660
SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLATLSNIDIRIP
Sbjct: 601 SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLATLSNIDIRIP 660
Query: 661 TGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAA 720
TGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAA
Sbjct: 661 TGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAA 720
Query: 721 QKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQ 780
QKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQ
Sbjct: 721 QKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQ 780
Query: 781 RQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYL 840
RQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYL
Sbjct: 781 RQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYL 840
Query: 841 THADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKT 900
THADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKT
Sbjct: 841 THADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKT 900
Query: 901 LRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLIL 960
LRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLIL
Sbjct: 901 LRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLIL 960
Query: 961 MIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLT 1020
MIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLT
Sbjct: 961 MIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLT 1020
Query: 1021 VEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTR 1080
VEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTR
Sbjct: 1021 VEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTR 1080
Query: 1081 STLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFS 1140
STLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFS
Sbjct: 1081 STLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFS 1140
Query: 1141 ETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASI 1200
ETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASI
Sbjct: 1141 ETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASI 1200
Query: 1201 ASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGT 1260
ASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGT
Sbjct: 1201 ASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGT 1260
Query: 1261 MDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLS 1320
MDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLS
Sbjct: 1261 MDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLS 1320
Query: 1321 LAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDD 1380
LAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDD
Sbjct: 1321 LAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDD 1380
Query: 1381 RLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEAT 1440
RLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEAT
Sbjct: 1381 RLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEAT 1440
Query: 1441 ASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAH 1500
ASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAH
Sbjct: 1441 ASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAH 1500
Query: 1501 KNGLFSTLVMTNK 1513
KNGLFSTLVMTNK
Sbjct: 1501 KNGLFSTLVMTNK 1513
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 2978 bits (7720), Expect = 0.0
Identities = 1513/1549 (97%), Positives = 1513/1549 (97%), Gaps = 36/1549 (2%)
Query: 1 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH 60
MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH
Sbjct: 1 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH 60
Query: 61 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV 120
NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV
Sbjct: 61 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV 120
Query: 121 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL 180
YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL
Sbjct: 121 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL 180
Query: 181 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK 240
MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK
Sbjct: 181 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK 240
Query: 241 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS 300
KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS
Sbjct: 241 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS 300
Query: 301 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL 360
STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL
Sbjct: 301 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL 360
Query: 361 ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE 420
ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE
Sbjct: 361 ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE 420
Query: 421 TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA 480
TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA
Sbjct: 421 TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA 480
Query: 481 QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI 540
QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI
Sbjct: 481 QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI 540
Query: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII 600
FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII
Sbjct: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII 600
Query: 601 SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGV----------------------- 637
SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGV
Sbjct: 601 SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTR 660
Query: 638 -------------VTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG 684
VTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG
Sbjct: 661 RLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG 720
Query: 685 EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR 744
EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR
Sbjct: 721 EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR 780
Query: 745 YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS 804
YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS
Sbjct: 781 YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS 840
Query: 805 ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 864
ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ
Sbjct: 841 ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 900
Query: 865 TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 924
TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE
Sbjct: 901 TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960
Query: 925 EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS 984
EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS
Sbjct: 961 EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS 1020
Query: 985 EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP 1044
EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP
Sbjct: 1021 EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP 1080
Query: 1045 IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL 1104
IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL
Sbjct: 1081 IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL 1140
Query: 1105 PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE 1164
PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE
Sbjct: 1141 PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE 1200
Query: 1165 LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN 1224
LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN
Sbjct: 1201 LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN 1260
Query: 1225 YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR 1284
YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR
Sbjct: 1261 YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR 1320
Query: 1285 YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL 1344
YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL
Sbjct: 1321 YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL 1380
Query: 1345 PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA 1404
PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA
Sbjct: 1381 PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA 1440
Query: 1405 VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV 1464
VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV
Sbjct: 1441 VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV 1500
Query: 1465 VTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK 1513
VTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK
Sbjct: 1501 VTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK 1549
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 2927 bits (7589), Expect = 0.0
Identities = 1487/1545 (96%), Positives = 1497/1545 (96%), Gaps = 36/1545 (2%)
Query: 1 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH 60
MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH
Sbjct: 1 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH 60
Query: 61 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV 120
NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV
Sbjct: 61 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV 120
Query: 121 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL 180
YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL
Sbjct: 121 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL 180
Query: 181 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK 240
MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK
Sbjct: 181 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK 240
Query: 241 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS 300
KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS
Sbjct: 241 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS 300
Query: 301 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL 360
STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL
Sbjct: 301 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL 360
Query: 361 ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE 420
ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE
Sbjct: 361 ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE 420
Query: 421 TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA 480
TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA
Sbjct: 421 TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA 480
Query: 481 QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI 540
QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI
Sbjct: 481 QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI 540
Query: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII 600
FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII
Sbjct: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII 600
Query: 601 SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGV----------------------- 637
SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGV
Sbjct: 601 SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTR 660
Query: 638 -------------VTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG 684
VTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG
Sbjct: 661 RLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG 720
Query: 685 EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR 744
EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR
Sbjct: 721 EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR 780
Query: 745 YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS 804
YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS
Sbjct: 781 YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS 840
Query: 805 ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 864
ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ
Sbjct: 841 ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 900
Query: 865 TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 924
TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE
Sbjct: 901 TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960
Query: 925 EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS 984
EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS
Sbjct: 961 EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS 1020
Query: 985 EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP 1044
EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP
Sbjct: 1021 EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP 1080
Query: 1045 IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL 1104
IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL
Sbjct: 1081 IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL 1140
Query: 1105 PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE 1164
PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE
Sbjct: 1141 PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE 1200
Query: 1165 LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN 1224
LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN
Sbjct: 1201 LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN 1260
Query: 1225 YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR 1284
YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR
Sbjct: 1261 YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR 1320
Query: 1285 YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL 1344
YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL
Sbjct: 1321 YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL 1380
Query: 1345 PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA 1404
PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA
Sbjct: 1381 PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA 1440
Query: 1405 VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV 1464
VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV
Sbjct: 1441 VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV 1500
Query: 1465 VTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
VTIAHRV +I+ A LV+V G ++E DT +LLA +NG+F++ V
Sbjct: 1501 VTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFV 1545
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 2060 bits (5338), Expect = 0.0
Identities = 1056/1581 (66%), Positives = 1254/1581 (79%), Gaps = 68/1581 (4%)
Query: 1 MSLSFCG--NNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQI 58
M L+FCG N+ ++Y ++ GVL N CFVDALN+VPHVFLLFITFPILFIGWGSQSSKV I
Sbjct: 1 MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHI 60
Query: 59 HHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTS 118
HH+TWLHFPGHNLRWILTF LLFV VCEIAEGI+SD ES HLHL+MPA M F+A TS
Sbjct: 61 HHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESHHLHLYMPAGMAFMAAVTS 120
Query: 119 IVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNG 178
+VYYHNIETSNFPKLL+AL +YW +AFITKTIK VK+ + S LRFC+TG++VIL G
Sbjct: 121 VVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLVILYG 180
Query: 179 LLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISA 238
+L+ VE+NVIRVRRY+FF P++VKPPEDLQDLGVRFLQPFVNLLSK TYWWMN I +A
Sbjct: 181 MLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTA 240
Query: 239 HKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPIL 298
HKKPIDL+AIGKLPIAMRA+TNY L +A++ Q +K +IW A+ AFGR ++
Sbjct: 241 HKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLV 300
Query: 299 LSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISET--LSSKEFLENAYVLAV 356
LSSTFR LADLLGFAGPLCI GIV + + + T +SS+EFL NAYVLAV
Sbjct: 301 LSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAV 360
Query: 357 LLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNL 416
LLFLAL+LQRTFLQASYYV IETGINLRGA+ IYNKI+ LSTSNLSMGEMT GQI NL
Sbjct: 361 LLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNL 420
Query: 417 VAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATK 476
VAI+TNQLMWF FLCPNLWAMPVQII+GVILLY +LG SAL+GAAVI+LLAP+QYF+ATK
Sbjct: 421 VAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATK 480
Query: 477 LAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYT 536
L++AQ+STL+YS ERLK+TNE+L+GIKLLKLYAWE+IF VE TR KE++SL+ FA+YT
Sbjct: 481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYT 540
Query: 537 SLSIFMNAAIPIAAVLATFVTH-AYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFA 595
S+SIFMN AIPIAAVL TFV H ++ + P+ AFASLSLFHILVTPLFLLS+VVR
Sbjct: 541 SISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRST 600
Query: 596 VKAIISVQKLNEFLLSDEIGDDSWRTGE----------SSLPF----------ESCKKHT 635
VKA++SVQKL+EFL S EI ++ E ++P E C+ T
Sbjct: 601 VKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLT 660
Query: 636 GV------------------VTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKS 676
G + GYF+W G+ TLSNI IRIP GQLTMIVGQVGCGKS
Sbjct: 661 GPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKS 720
Query: 677 SLLLAILGEMQTLEGKVHWSNVNESE----PSFEATRS-----RNRYSVAYAAQKPWLLN 727
SLLLA LGEMQ + G V WS++ +SE PS E + R R VAYA+QKPWLLN
Sbjct: 721 SLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLN 780
Query: 728 ATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVA 787
ATVEENI F SPFNKQRYK V +ACSLQPDID+LP GDQT+IGERGINLSGGQRQRI VA
Sbjct: 781 ATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVA 840
Query: 788 RALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWII 847
RALYQ+ N+VFLDDPFSALDIHLSDHLMQ GIL+ L+DDKRT+VLVTHKLQYL HADWII
Sbjct: 841 RALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWII 900
Query: 848 AMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLER-KTLRRAMY 906
AMKDG++ REGTLKD Q + +L+EHWKTLMNRQDQELEK+ ++ E + L RAM
Sbjct: 901 AMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMS 960
Query: 907 SREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKL 966
SR+ Q E+E+EEE E +EDDN+S+++ R ++PW+ C +YL+S G LL L++FS+L
Sbjct: 961 SRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQL 1020
Query: 967 LKHSVIVAIDYWLATWTSEY----------SINNTGKADQTYYVAGFSILCGAGIFLCLV 1016
LKH V+VAIDYWLA WT S++ DQT Y F++LC GI LCLV
Sbjct: 1021 LKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLV 1080
Query: 1017 TSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLE 1076
TS+TVEW GL AK LH +LLN+IIL P+RFF+TTPLG ILNRFS+D N IDQHIP TLE
Sbjct: 1081 TSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLE 1140
Query: 1077 SLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLL 1136
L+RSTLLC+SA+ +ISY TPVFLVALLPL + YFIQKYFRVAS+DLQ+LDD+TQLPLL
Sbjct: 1141 CLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLL 1200
Query: 1137 CHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVL 1196
HF+ET EGLTTIRAFR+E RF+Q++LE TD+NNIA LFL+AANRWLEVR +Y+GAC+VL
Sbjct: 1201 SHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVL 1260
Query: 1197 TASIASISGSSN----SGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTM 1252
A++ SIS S + +GLVGLGL YAL ++NYLNW+VRNLAD+E+Q+GAVK+++ L
Sbjct: 1261 IAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKT 1320
Query: 1253 ESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRT 1312
E+E+YEG + PS +P++WP +G+I+I +L VRY+++LKPVLKHV A I PGQK+GICGRT
Sbjct: 1321 EAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRT 1380
Query: 1313 GSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD 1372
GSGKSS SLAFFRMVD F+G I+IDGIDI+KLPLHTLRSRLSIILQDP+LFSG+IRFNLD
Sbjct: 1381 GSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLD 1440
Query: 1373 PECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSS 1432
PE KC+D LWEALEIAQLK +VK+LPGGLDA++TEGGENFS GQRQLFCLARAFVRK+S
Sbjct: 1441 PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTS 1500
Query: 1433 ILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECD 1492
I IMDEATASIDMATENILQKVVMTAFADRTVVTIAHRV +I+ A LV+V G ++E D
Sbjct: 1501 IFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFD 1560
Query: 1493 TVPNLLAHKNGLFSTLVMTNK 1513
LL+ K+ +F++ V +K
Sbjct: 1561 KPEKLLSRKDSVFASFVRADK 1581
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 768 bits (1984), Expect = 0.0
Identities = 468/1360 (34%), Positives = 740/1360 (54%), Gaps = 121/1360 (8%)
Query: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
Query: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
Query: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
Query: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
Query: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWG-SGLATLSNIDIRIPTGQ 663
L FL +E+ DS E + ++ V N F+W S TL+ I IP G
Sbjct: 616 LRIFLSHEELEPDSI---ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGA 672
Query: 664 LTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKP 723
L +VGQVGCGKSSLL A+L EM +EG V SVAY Q+
Sbjct: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-----------------SVAYVPQQA 715
Query: 724 WLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQR 783
W+ N ++ ENI FG + Y++V AC+L PD+++LP GD+TEIGE+G+NLSGGQ+QR
Sbjct: 716 WIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQR 775
Query: 784 ICVARALYQNTNIVFLDDPFSALDIHLSDHLMQ-----EGILKFLQDDKRTLVLVTHKLQ 838
+ +ARA+Y N +I DDP SA+D H+ H+ + +G+LK +T +LVTH +
Sbjct: 776 VSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK-----NKTRILVTHSMS 830
Query: 839 YLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQELEKD--------- 888
YL D II M G + G+ +++ +D E +T + Q+Q+ E++
Sbjct: 831 YLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPG 890
Query: 889 MEADQTT------------LERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDN---MST 933
EA Q L+R+ + YS + E ++ E +++ M
Sbjct: 891 KEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEA 950
Query: 934 VMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGK 993
++ W Y+ + G F+ L IF + H +A +YWL+ WT + +N T
Sbjct: 951 DKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGT-- 1008
Query: 994 ADQTYYVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDT 1050
Q + S+ GI + S+ V G+ A++ LH +LL+ I+ P+ FF+
Sbjct: 1009 --QEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFER 1066
Query: 1051 TPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAF 1110
TP G ++NRFS + + +D IP ++ S + A +I ATP+ + + PLG+ +
Sbjct: 1067 TPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIY 1126
Query: 1111 YFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNN 1170
+F+Q+++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF + D N
Sbjct: 1127 FFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQ 1186
Query: 1171 IAYLFLSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGLLYALTITNYLNW 1228
AY ANRWL VR + +G CIVL A++ ++ S ++GLVGL + Y+L +T YLNW
Sbjct: 1187 KAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNW 1246
Query: 1229 VVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENN 1288
+VR +++E + AV+++ + E E + + P WPQ G ++ + C+RY +
Sbjct: 1247 LVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYRED 1305
Query: 1289 LKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHT 1348
L VL+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+IDGI+I+K+ LH
Sbjct: 1306 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1365
Query: 1349 LRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTE 1408
LR +++II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V +LP LD E
Sbjct: 1366 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1425
Query: 1409 GGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIA 1468
GGEN SVGQRQL CLARA +RK+ IL++DEATA++D+ T++++Q + T F D TV+TIA
Sbjct: 1426 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIA 1485
Query: 1469 HRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1508
HR+++IMD V+V +G + E P+ L + GLF ++
Sbjct: 1486 HRLNTIMDYTRVIVLDKGEIQEYG-APSDLLQQRGLFYSM 1524
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 753 bits (1943), Expect = 0.0
Identities = 498/1512 (32%), Positives = 780/1512 (51%), Gaps = 150/1512 (9%)
Query: 71 LRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGF-VATTTSIVYYHNIE-TS 128
L W +++A LF + G R + P V+G + T ++ Y ++
Sbjct: 79 LLWCVSWADLFYSFHGLVHG------RAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQ 132
Query: 129 NFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCI--TGMMVILNGLLMAVEIN 186
+ L++ FL V A + K++ G RF ++L+ L++A
Sbjct: 133 SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILAC--- 189
Query: 187 VIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLK 246
R F + + V P + + LS+ +WW + I ++ P++ K
Sbjct: 190 ---FREKPPFFSAKNVDPNP--------YPETSAGFLSRLFFWWFTKMAIYGYRHPLEEK 238
Query: 247 AIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPN----------------------RTPS 284
+ L R+ L +A+ +Q+K+ A H R PS
Sbjct: 239 DLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPS 298
Query: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
A+ FG L+S+ F+ + DLL F P +S +++ IS ++
Sbjct: 299 FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRF-------------ISNPMAP 345
Query: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
+ +++A L+FL ++Q LQ Y+ TG+ R ++ +IY K L ++ S
Sbjct: 346 SWW---GFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKR 402
Query: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
T+G+I NL++++ + M LW+ P+QII+ + L+ LG S L G A +V
Sbjct: 403 AS--TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMV 460
Query: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
LL P+ +A K+ Q + R+K +EIL GIK+LKLYAWE F K VE R
Sbjct: 461 LLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQG 520
Query: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVT 583
EL L+T A + + F P L T + Y NN+ AE AF S+SLF+IL
Sbjct: 521 ELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRL 580
Query: 584 PLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYF 643
PL +L ++ +A +S++++ +FL +E+ S S P + H+G F
Sbjct: 581 PLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTIS-PGYAITIHSGT-----F 634
Query: 644 SWGSGLA-TLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESE 702
+W L TL ++DI++P G L +VG VGCGKSSL+ A+LGEM+ LEGKVH
Sbjct: 635 TWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG----- 689
Query: 703 PSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLP 762
SVAY Q+ W+ N T++EN+ FG N +RY+ +AC+L D+++LP
Sbjct: 690 ------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLP 737
Query: 763 FGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQ-----E 817
GDQTEIGE+GINLSGGQRQR+ +ARA+Y + +I LDDP SA+D H++ H+ E
Sbjct: 738 GGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPE 797
Query: 818 GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVE-------- 869
G+L +T VLVTH + +L D+II + DG V G + ++
Sbjct: 798 GVLA-----GKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNY 852
Query: 870 --------LYEHWKTLMNRQDQE--LEKDMEADQTTLERKT----LRRAMYSREAKAQME 915
L + W L +D+E L +D ++ T L + + + R+ A
Sbjct: 853 APDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSS 912
Query: 916 DED--------------EEEEEEEDEDDNMSTVMRLRT--KMPWKTCWRYLTSGGFFLLI 959
D + E+ + E + D T + W Y + G +
Sbjct: 913 DGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTL 972
Query: 960 LMIFSKLLKHSVIVAIDYWLATWTSEYSI----NNTGKADQTYYVAGFSILCGAGIFLCL 1015
+ + + + + + WL+ WT++ NNT Y A IL G FL +
Sbjct: 973 AICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVY--AALGILQG---FLVM 1027
Query: 1016 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1075
+ ++ + G+ AA+ LH LL+ I P FFDTTP G ILN FS D ++D+ + P +
Sbjct: 1028 LAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVI 1087
Query: 1076 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1135
L S +S + +I +TP+F V +LPL V + +Q+++ S+ L+ L+ ++ P+
Sbjct: 1088 LMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPI 1147
Query: 1136 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1195
HFSET G + IRA+ F+ D N + +NRWL + +++G C+V
Sbjct: 1148 YSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVV 1207
Query: 1196 LTASIASISGSS--NSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTME 1253
L A++ ++ G S N GLVGL + Y+L +T LNW++R ++DLE + AV++V + E
Sbjct: 1208 LFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTE 1267
Query: 1254 SENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1313
+E ++ S+ PE WP GE++ + VRY L VL+ + ++ G+KVGI GRTG
Sbjct: 1268 TEA-PWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTG 1326
Query: 1314 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1373
+GKSS++L FR+++ G+I IDG++++ + LH LRS+L+II QDPILFSG++R NLDP
Sbjct: 1327 AGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDP 1386
Query: 1374 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1433
+++ +W ALE++ L V S P GLD +EGGEN SVGQRQL CLARA +RKS I
Sbjct: 1387 FGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRI 1446
Query: 1434 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDT 1493
L++DEATA+ID+ T+N++Q + T F TV+TIAHR+++IMD VLV +G++ E D+
Sbjct: 1447 LVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDS 1506
Query: 1494 VPNLLAHKNGLF 1505
NL+A + G+F
Sbjct: 1507 PANLIAAR-GIF 1517
Score = 99.4 bits (246), Expect = 2e-20
Identities = 119/477 (24%), Positives = 200/477 (41%), Gaps = 53/477 (11%)
Query: 1053 LGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAI-------GMISYATPVFLVALLP 1105
+G I+N S D + P L L + L + AI G A F+V L+P
Sbjct: 406 VGEIVNLMSVDAQRF-MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIP 464
Query: 1106 LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQ----- 1160
L A + F+V L++ +++ L+ SE G+ ++ + E F +
Sbjct: 465 LNGAVAVKMRAFQVKQMKLKD----SRIKLM---SEILNGIKVLKLYAWEPSFLKQVEGI 517
Query: 1161 RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLL 1217
R EL AYL + W+ + +L I L + + + V + L
Sbjct: 518 RQGELQLLRTAAYLHTTTTFTWM--CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLF 575
Query: 1218 YALTIT-NYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG-E 1275
L + N L ++ NL V + K++ FL+ E +DP V G
Sbjct: 576 NILRLPLNMLPQLISNLTQASVSL---KRIQQFLSQEE------LDPQSVERKTISPGYA 626
Query: 1276 IKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIV 1335
I IH + +L P L + + G V + G G GKSSL A ++ +GK+
Sbjct: 627 ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH 686
Query: 1336 IDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMV 1395
+ G ++ +P + LQ+ +LF + L+P+ R + LE L +
Sbjct: 687 MKG-SVAYVPQQAWIQNCT--LQENVLFGKA----LNPK------RYQQTLEACALLADL 733
Query: 1396 KSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKV 1454
+ LPGG + E G N S GQRQ LARA + I ++D+ +++D ++I V
Sbjct: 734 EMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHV 793
Query: 1455 V--MTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
+ A +T V + H +S + ++V ++G + E P LL +NG F+ +
Sbjct: 794 IGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALL-QRNGSFANFL 849
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 726 bits (1873), Expect = 0.0
Identities = 460/1467 (31%), Positives = 750/1467 (51%), Gaps = 181/1467 (12%)
Query: 137 LFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLLMAVEINVIRVRRYVFF 196
L L+W+++ + T + ++ L N + + I G + + I F
Sbjct: 132 LSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILIFS------AFS 185
Query: 197 MNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMR 256
N + P + + LS TY W +++I+ +K+P+ L+ + ++ M+
Sbjct: 186 ENNESSNNPSSI-----------ASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMK 234
Query: 257 AVT-----------------------------------------------NYVCLKDAYE 269
T + + L+D
Sbjct: 235 TKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDV-- 292
Query: 270 EQKKKVADHPNRTPSIWL--AMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNE 327
E+KKK + P WL A+++ F +L S + + D+ F P + ++ ++
Sbjct: 293 EKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASD 352
Query: 328 TQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGAL 387
+L Y+ A+LLF A ++Q LQ + + + G+ +R A+
Sbjct: 353 RDT----------------YLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAI 396
Query: 388 LAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVIL 447
+A +Y K L LS NL+ E T+G+ NL++++ +LM LW+ +QI++ +
Sbjct: 397 MASVYKKALTLS--NLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFF 454
Query: 448 LYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKL 507
L+ LG S L G V+VL+ PI ++TK Q + +RLK NEIL GIK+LK
Sbjct: 455 LWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKY 514
Query: 508 YAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLK 567
+AWE F V+ R KEL +L F+ + IF+ P+ + TF + NN+
Sbjct: 515 FAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNIL 574
Query: 568 PAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSL 626
A+ AF S++LF+IL PL +L ++ ++A +S ++L ++L D++ + R
Sbjct: 575 DAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIR---HDC 631
Query: 627 PFESCKKHTGVVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGE 685
F+ + + F+W AT+ ++++ I GQL ++G VG GKSSL+ A+LGE
Sbjct: 632 NFDKAMQFS----EASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGE 687
Query: 686 MQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRY 745
M+ + G + + AY Q+ W+ N T+++NI FG+ FN++RY
Sbjct: 688 MENVHGHITIKG-----------------TTAYVPQQSWIQNGTIKDNILFGTEFNEKRY 730
Query: 746 KAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSA 805
+ V +AC+L PD+++LP GD EIGE+GINLSGGQ+QRI +ARA YQN +I LDDP SA
Sbjct: 731 QQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSA 790
Query: 806 LDIHLSDHLMQE-----GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTL 860
+D H+ H+ + G+LK +T +LVTH + +L D I+ + +G+++ +G+
Sbjct: 791 VDAHVGKHIFNKVLGPNGLLK-----GKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSY 845
Query: 861 KDIQTKDVELYEHWKTLMNRQDQELEKDM----------------------EADQTTLER 898
+ K E ++ KT + E E + +A T+ R
Sbjct: 846 SALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRR 905
Query: 899 -------------------KTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT 939
K+LR ++ +R + EDE+ + ++ + + + T
Sbjct: 906 ENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIET-----G 960
Query: 940 KMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNT-----GKA 994
K+ + YL + G F + +I + ++ + + WL+ WTS+ I N+ +
Sbjct: 961 KVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQR 1020
Query: 995 DQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKN-LHHNLLNKIILGPIRFFDTTPL 1053
D V G ++ GIF+ + + G A N LH LLN I+ P+RFFDTTP
Sbjct: 1021 DMRVGVYG-ALGLAQGIFVFIAHFWSA--FGFVHASNILHKQLLNNILRAPMRFFDTTPT 1077
Query: 1054 GLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFI 1113
G I+NRF+ D + +D +P +L S L +S + MI ATPVF + ++PLG+ + +
Sbjct: 1078 GRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSV 1137
Query: 1114 QKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAY 1173
Q ++ S+ L+ LD T+ P+ HFSET GL IRAF H+ RF + DTN
Sbjct: 1138 QMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCV 1197
Query: 1174 LFLSAANRWLEVRTDYLGACIVLTASIASI--SGSSNSGLVGLGLLYALTITNYLNWVVR 1231
+NRWL +R + +G V +++ + + + VG L AL IT LNW+VR
Sbjct: 1198 FSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVR 1257
Query: 1232 NLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKP 1291
+++E + AV+++ + +E+E + + P WP +G+I+ ++ VRY L
Sbjct: 1258 MTSEIETNIVAVERITEYTKVENE--APWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDL 1315
Query: 1292 VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRS 1351
VL+ + I +K+G+ GRTG+GKSSL+ FR+++ G+I+IDG+DI+ + LH LR
Sbjct: 1316 VLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLRE 1375
Query: 1352 RLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGE 1411
+L+II QDPILFSGS+R NLDP +D+ +W+ALE+A LK+ V SL GL VTE G
Sbjct: 1376 KLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGG 1435
Query: 1412 NFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRV 1471
N S+GQRQL CL RA +RKS IL++DEATA++D+ T+N++Q + FA TV+TIAHR+
Sbjct: 1436 NLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRL 1495
Query: 1472 SSIMDAGLVLVFSEGILVECDTVPNLL 1498
+IMD+ V+V G ++EC + LL
Sbjct: 1496 HTIMDSDKVMVLDNGKIIECGSPEELL 1522
Score = 75.9 bits (185), Expect = 3e-13
Identities = 140/671 (20%), Positives = 274/671 (40%), Gaps = 68/671 (10%)
Query: 859 TLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREA------KA 912
TL+D+ D E+ KTL+++ + ++++++ + L+R+ + + + A K
Sbjct: 222 TLEDVWEVDEEMKT--KTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKN 279
Query: 913 QMEDED----EEEEEEEDEDDNMSTVMRL-RTKMPWKTCWRYLTSGGFFLLILMIFS--- 964
Q + +D E+ E+++ + V + K +KT + L L+ IF+
Sbjct: 280 QSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVS 339
Query: 965 -KLLKHSVIVAIDYWLATWTSEYS--INNTGKADQTYYVAGFSILC---GAGIFLCLVTS 1018
+LLK + A D W + T Q++ + + LC G + ++ S
Sbjct: 340 PQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMAS 399
Query: 1019 LTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESL 1078
+ + + L+ NL K +G +N S D + + + L
Sbjct: 400 VYKKALTLS-------NLARK----------EYTVGETVNLMSVDAQKL-MDVTNFMHML 441
Query: 1079 TRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCH 1138
S L + +I + ++A + + V I SK +Q + + L
Sbjct: 442 WSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKI 501
Query: 1139 FSETAEGLTTIRAFRHETRFKQRMLELTDT---NNIAYLFLSAANRWLEVRTDYLGACIV 1195
+E G+ ++ F E F+ ++ L N +A+ L ++ T L + +
Sbjct: 502 MNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVT 561
Query: 1196 LTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE 1255
+ + SN+ L ++T+ N L + L+ L + + ++ + S T E
Sbjct: 562 FSVYVLV---DSNNILDAQKAFTSITLFNILRFP---LSMLPMMISSMLQA-SVSTERLE 614
Query: 1256 NYEG--TMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1313
Y G +D S + + ++ + +E++ + ++ V I GQ V + G G
Sbjct: 615 KYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVG 674
Query: 1314 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1373
SGKSSL A ++ G I I G + + Q + +G+I+ N+
Sbjct: 675 SGKSSLISAMLGEMENVHGHITIKGTT-------------AYVPQQSWIQNGTIKDNILF 721
Query: 1374 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1433
+ + R + LE L ++ LPGG A + E G N S GQ+Q LARA + I
Sbjct: 722 GTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDI 781
Query: 1434 LIMDEATASIDM-ATENILQKVV--MTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVE 1490
++D+ +++D ++I KV+ +T + + H + + ++V G +VE
Sbjct: 782 YLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVE 841
Query: 1491 CDTVPNLLAHK 1501
+ LLA K
Sbjct: 842 KGSYSALLAKK 852
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 682 bits (1761), Expect = 0.0
Identities = 423/1267 (33%), Positives = 672/1267 (53%), Gaps = 120/1267 (9%)
Query: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
Query: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
Query: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
Query: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
Query: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWG-SGLATLSNIDIRIPTGQ 663
L FL +E+ DS E + ++ V N F+W S TL+ I IP G
Sbjct: 616 LRIFLSHEELEPDSI---ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGA 672
Query: 664 LTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKP 723
L +VGQVGCGKSSLL A+L EM +EG V SVAY Q+
Sbjct: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-----------------SVAYVPQQA 715
Query: 724 WLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQR 783
W+ N ++ ENI FG + Y++V AC+L PD+++LP GD+TEIGE+G+NLSGGQ+QR
Sbjct: 716 WIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQR 775
Query: 784 ICVARALYQNTNIVFLDDPFSALDIHLSDHLMQ-----EGILKFLQDDKRTLVLVTHKLQ 838
+ +ARA+Y N +I DDP SA+D H+ H+ + +G+LK +T +LVTH +
Sbjct: 776 VSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK-----NKTRILVTHSMS 830
Query: 839 YLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQELEKD--------- 888
YL D II M G + G+ +++ +D E +T + Q+Q+ E++
Sbjct: 831 YLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPG 890
Query: 889 MEADQTT------------LERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDN---MST 933
EA Q L+R+ + YS + E ++ E +++ M
Sbjct: 891 KEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEA 950
Query: 934 VMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGK 993
++ W Y+ + G F+ L IF + H +A +YWL+ WT + +N T
Sbjct: 951 DKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGT-- 1008
Query: 994 ADQTYYVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDT 1050
Q + S+ GI + S+ V G+ A++ LH +LL+ I+ P+ FF+
Sbjct: 1009 --QEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFER 1066
Query: 1051 TPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAF 1110
TP G ++NRFS + + +D IP ++ S + A +I ATP+ + + PLG+ +
Sbjct: 1067 TPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIY 1126
Query: 1111 YFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNN 1170
+F+Q+++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF + D N
Sbjct: 1127 FFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQ 1186
Query: 1171 IAYLFLSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGLLYALTITNYLNW 1228
AY ANRWL VR + +G CIVL A++ ++ S ++GLVGL + Y+L +T YLNW
Sbjct: 1187 KAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNW 1246
Query: 1229 VVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENN 1288
+VR +++E + AV+++ + E E + + P WPQ G ++ + C+RY +
Sbjct: 1247 LVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYRED 1305
Query: 1289 LKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHT 1348
L VL+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+IDGI+I+K+ LH
Sbjct: 1306 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1365
Query: 1349 LRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTE 1408
LR +++II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V +LP LD E
Sbjct: 1366 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1425
Query: 1409 GGENFSV 1415
GGEN V
Sbjct: 1426 GGENLRV 1432
Score = 85.1 bits (209), Expect = 5e-16
Identities = 139/651 (21%), Positives = 259/651 (39%), Gaps = 88/651 (13%)
Query: 898 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 953
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
Query: 954 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1009
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
Query: 1010 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1063
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 1064 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1116
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
Query: 1117 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1171
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
Query: 1172 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1227
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 1228 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1283
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
Query: 1284 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISK 1343
+ + P L + I G V + G+ G GKSSL A +D +G + I G
Sbjct: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG----- 706
Query: 1344 LPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLD 1403
++ + Q + + S+R N+ C+ + ++ L ++ LP G
Sbjct: 707 --------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDR 758
Query: 1404 AVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKVV--MTAFA 1460
+ E G N S GQ+Q LARA + I + D+ +++D ++I + V+
Sbjct: 759 TEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK 818
Query: 1461 DRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMT 1511
++T + + H +S + +++V S G + E + LLA ++G F+ + T
Sbjct: 819 NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA-RDGAFAEFLRT 868
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 678 bits (1750), Expect = 0.0
Identities = 437/1355 (32%), Positives = 696/1355 (51%), Gaps = 167/1355 (12%)
Query: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
Query: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
Query: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
Query: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
Query: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWG-SGLATLSNIDIRIPTGQ 663
L FL +E+ DS E + ++ V N F+W S TL+ I IP G
Sbjct: 616 LRIFLSHEELEPDSI---ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGA 672
Query: 664 LTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKP 723
L +VGQVGCGKSSLL A+L EM +EG V SVAY Q+
Sbjct: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-----------------SVAYVPQQA 715
Query: 724 WLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQR 783
W+ N ++ ENI FG + Y++V AC+L PD+++ L G R
Sbjct: 716 WIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEI---------------LPSGDRTE 760
Query: 784 ICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHA 843
I ++T +LVTH + YL
Sbjct: 761 I-----------------------------------------GEKTRILVTHSMSYLPQV 779
Query: 844 DWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQELEKD---------MEADQ 893
D II M G + G+ +++ +D E +T + Q+Q+ E++ EA Q
Sbjct: 780 DVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQ 839
Query: 894 TT------------LERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDN---MSTVMRLR 938
L+R+ + YS + E ++ E +++ M
Sbjct: 840 MENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQT 899
Query: 939 TKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTY 998
++ W Y+ + G F+ L IF + H +A +YWL+ WT + +N T Q +
Sbjct: 900 GQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGT----QEH 955
Query: 999 YVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGL 1055
S+ GI + S+ V G+ A++ LH +LL+ I+ P+ FF+ TP G
Sbjct: 956 TKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGN 1015
Query: 1056 ILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQK 1115
++NRFS + + +D IP ++ S + A +I ATP+ + + PLG+ ++F+Q+
Sbjct: 1016 LVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQR 1075
Query: 1116 YFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLF 1175
++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF + D N AY
Sbjct: 1076 FYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYP 1135
Query: 1176 LSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGLLYALTITNYLNWVVRNL 1233
ANRWL VR + +G CIVL A++ ++ S ++GLVGL + Y+L +T YLNW+VR
Sbjct: 1136 SIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMS 1195
Query: 1234 ADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVL 1293
+++E + AV+++ + E E + + P WPQ G ++ + C+RY +L VL
Sbjct: 1196 SEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVL 1254
Query: 1294 KHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRL 1353
+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+IDGI+I+K+ LH LR ++
Sbjct: 1255 RHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKI 1314
Query: 1354 SIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENF 1413
+II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V +LP LD EGGEN
Sbjct: 1315 TIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1374
Query: 1414 SVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSS 1473
SVGQRQL CLARA +RK+ IL++DEATA++D+ T++++Q + T F D TV+TIAHR+++
Sbjct: 1375 SVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNT 1434
Query: 1474 IMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1508
IMD V+V +G + E P+ L + GLF ++
Sbjct: 1435 IMDYTRVIVLDKGEIQEYG-APSDLLQQRGLFYSM 1468
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 665 bits (1715), Expect = 0.0
Identities = 437/1331 (32%), Positives = 707/1331 (53%), Gaps = 84/1331 (6%)
Query: 200 QKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVT 259
Q+VKP LQD NL S+ +WW+N L HK+ ++ + + R+
Sbjct: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
Query: 260 NYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCIS 319
L+ ++++ + A++ + PS+ A+ + + + L+ F + + P+ +
Sbjct: 56 LGEELQGFWDKEVLR-AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
Query: 320 GIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLA-VLLFLALILQRTFLQASYYVTIE 378
I+ N N + L AY A VL F LIL L Y+ ++
Sbjct: 115 KII-------NYFENYDPMDSVA-----LNTAYAYATVLTFCTLIL--AILHHLYFYHVQ 160
Query: 379 -TGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
G+ LR A+ MIY K LRLS N++MG+ T GQI NL++ + N+ LWA
Sbjct: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
Query: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
P+Q I LL+ +G S L G AV+++L P+Q + + T ++ R++ NE
Sbjct: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
Query: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
++ GI+++K+YAWE F + R KE+S + + +++ + V TF T
Sbjct: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
Query: 558 HAYASGNNLKPAEAFASLSLFHI--LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIG 615
+ G+ + + F +++L+ L LF S + R + +AI+S++++ FLL DEI
Sbjct: 339 YVLL-GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVS-EAIVSIRRIQTFLLLDEIS 396
Query: 616 DDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGK 675
+ LP + K ++ S TL + + G+L +VG VG GK
Sbjct: 397 QRN-----RQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
Query: 676 SSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENIT 735
SSLL A+LGE+ G V + R +AY +Q+PW+ + T+ NI
Sbjct: 452 SSLLSAVLGELAPSHGLV-------------SVHGR----IAYVSQQPWVFSGTLRSNIL 494
Query: 736 FGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTN 795
FG + K+RY+ V AC+L+ D+ LL GD T IG+RG LSGGQ+ R+ +ARA+YQ+ +
Sbjct: 495 FGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDAD 554
Query: 796 IVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVL 855
I LDDP SA+D +S HL + I + L + + +LVTH+LQYL A I+ +KDG ++
Sbjct: 555 IYLLDDPLSAVDAEVSRHLFELCICQILHE--KITILVTHQLQYLKAASQILILKDGKMV 612
Query: 856 REGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMY--SREAKAQ 913
++GT + ++ + +L+ + ++E E+ TL +T + + ++
Sbjct: 613 QKGTYTEFLKSGID----FGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPS 668
Query: 914 MEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIV 973
++D E ++ E+ +S R K+ ++ Y +G + I+ IF LL + V
Sbjct: 669 LKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHW--IVFIFLILLNTAAQV 726
Query: 974 AI---DYWLATWTSEYSINN---------TGKADQTYYVAGFSILCGAGIFLCLVTSLTV 1021
A D+WL+ W ++ S+ N T K D +Y+ +S L A + + SL V
Sbjct: 727 AYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLV 786
Query: 1022 EWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRS 1081
++ + +++ LH+ + I+ P+ FFD P+G ILNRFS D +D +P T ++
Sbjct: 787 FYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQT 846
Query: 1082 TLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSE 1141
L + + + P + L+PLG+ F F+++YF S+D++ L+ +T+ P+ H S
Sbjct: 847 LLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSS 906
Query: 1142 TAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIA 1201
+ +GL TIRA++ E R ++ D ++ A+ +RW VR D + A V+ +
Sbjct: 907 SLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFG 966
Query: 1202 SI--SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESEN-YE 1258
S+ + + ++G VGL L YALT+ W VR A++E M +V++V + +E E +E
Sbjct: 967 SLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWE 1026
Query: 1259 GTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSS 1318
P P WP EG I ++ Y VLKH+ A IK +KVGI GRTG+GKSS
Sbjct: 1027 YQKRP---PPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSS 1083
Query: 1319 LSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCT 1378
L A FR+ + +GKI ID I +++ LH LR ++SII Q+P+LF+G++R NLDP + T
Sbjct: 1084 LISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHT 1142
Query: 1379 DDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDE 1438
D+ LW AL+ QLK ++ LPG +D + E G NFSVGQRQL CLARA +RK+ ILI+DE
Sbjct: 1143 DEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDE 1202
Query: 1439 ATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLL 1498
ATA++D T+ ++QK + FA TV+TIAHR+++I+D+ ++V G L E D LL
Sbjct: 1203 ATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLL 1262
Query: 1499 AHKNGLFSTLV 1509
+K LF +V
Sbjct: 1263 QNKESLFYKMV 1273
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 631 bits (1628), Expect = e-180
Identities = 409/1289 (31%), Positives = 665/1289 (51%), Gaps = 124/1289 (9%)
Query: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
+W A+Y AFGR L + + +LGF+GPL +S +V + E Q E LS
Sbjct: 230 LWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQ----------EPLSH 279
Query: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
L A LA L +LQ + Y VT++ RGA+L ++Y K L+L S
Sbjct: 280 G--LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQA----RGAVLNILYCKALQLGPSRPP 333
Query: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
GE NL+ ++ +L+ F W +P+Q+ + + LLY +G + + G + +
Sbjct: 334 TGEAL-----NLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILAL 388
Query: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
LL P+ IAT++ + + L + R+K E+L GI+++K WE VE R +
Sbjct: 389 LLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRAR 448
Query: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTP 584
EL L+ + +++ AA+P+ + F+T+ G+ L + F +L+L +L+ P
Sbjct: 449 ELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLM-GHQLTATKVFTALALVRMLILP 507
Query: 585 LFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGE-----SSLPFESC-----KKH 634
L V+ ++A +S+ ++ FL ++ + + + + + C +
Sbjct: 508 LNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPS 567
Query: 635 TGVVTNG-YFSW---GSGLAT-LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTL 689
T + +G FSW G+ L T +S+++++ G L IVG+VGCGKSSLL AI GE+ L
Sbjct: 568 TVLELHGALFSWDPVGTSLETFISHLEVK--KGMLVGIVGKVGCGKSSLLAAIAGELHRL 625
Query: 690 EGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVT 749
G V A R ++ A Q+PW+ AT+ +NI FG F+ Q YK V
Sbjct: 626 RGHV-------------AVRGLSK-GFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVL 671
Query: 750 DACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIH 809
+AC+L D+ +LP GDQTE+GE+G+ LSGGQR RI +ARA+YQ + LDDP +A+D
Sbjct: 672 EACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDAD 731
Query: 810 LSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVE 869
+++HL+ IL L R +L TH+ +YL AD ++ M+ G ++R G +I
Sbjct: 732 VANHLLHRCILGMLSYTTR--LLCTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQA 789
Query: 870 LYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD 929
+ + W E E+D T + + K +E+E E+
Sbjct: 790 VPKAWA----------ENGQESDSATAQS-----VQNPEKTKEGLEEEQSTSGRLLQEES 834
Query: 930 NMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSIN 989
+ L ++ W+ + G L + ++FS LL + A D+WL+ W S+
Sbjct: 835 KKEGAVALHV---YQAYWKAVGQG---LALAILFSLLLMQATRNAADWWLSHWISQLKAE 888
Query: 990 NT-----------------------------------------GKADQTYYVAGFSILCG 1008
N+ G +D +Y+ ++ + G
Sbjct: 889 NSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAG 948
Query: 1009 AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIID 1068
L+ ++ L AA LH LL+++++ P+ FF+ TP G ILNRFS+D D
Sbjct: 949 VNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACAD 1008
Query: 1069 QHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELD 1128
+P L L + L + ++ P L+ L PL + +Y +Q+++R +S++L+ L
Sbjct: 1009 DSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLG 1068
Query: 1129 DSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTD 1188
T PL H ++T GL+ +RA RF++ L L + N SA +WL++R
Sbjct: 1069 SLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQ 1128
Query: 1189 YLGACIV-LTASIASI---SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVK 1244
+GA +V A IA + G +N GLVGL L YAL++T L+ +V + E + +V+
Sbjct: 1129 LMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVE 1188
Query: 1245 KVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQ 1304
++ + + +G P Q+ W +G ++ D+ + Y L L V ++PG+
Sbjct: 1189 RLEEYTCDLPQEPQG--QPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGE 1246
Query: 1305 KVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFS 1364
K+GI GRTGSGKSSL L FR+++ G++++DG+D S+L L LRS+L+II Q+P LFS
Sbjct: 1247 KLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFS 1306
Query: 1365 GSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLA 1424
G++R NLDP+ D LW+AL+ L ++ S+ GGLD + EGG + S+GQRQL CLA
Sbjct: 1307 GTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLA 1365
Query: 1425 RAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFS 1484
RA + + IL +DEATAS+D T+ +LQ+ + FA++TV+TIAHR+++I+++ VLV
Sbjct: 1366 RALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQ 1425
Query: 1485 EGILVECDTVPNLLAHKNGLFSTLVMTNK 1513
G +VE D+ L + LF L+ +++
Sbjct: 1426 AGRVVELDSPATLRNQPHSLFQQLLQSSQ 1454
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 611 bits (1576), Expect = e-174
Identities = 457/1491 (30%), Positives = 727/1491 (48%), Gaps = 110/1491 (7%)
Query: 67 PGHNLRWILTFALLFVHVCEIAEGI--VSDSRRESRHLHLFMPAVMGFVATTTSIVYYHN 124
P + +L FAL+ + +A + + E+ L P V ++ T + V+ +
Sbjct: 67 PLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEF-LIHPTV--WLTTMSFAVFLIH 123
Query: 125 IETSNFPKLLLALFLYWVMAFITKTIKLVKYCQ-SGLDISNLRFCITGMMVILNGLLMAV 183
E + LF YW++ F+ + +G +R T + + L ++
Sbjct: 124 TERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSL--VVAQF 181
Query: 184 EINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPI 243
++ + + F +PQ+ P + G F SKAT+WW++ L+ +++P+
Sbjct: 182 VLSCLADQPPFFPEDPQQSNP---CPETGAAFP-------SKATFWWVSGLVWRGYRRPL 231
Query: 244 ---DLKAIGKL----PIAMRAVTNYVCLKDAYEEQKKKVA---------DHPNRTP---- 283
DL ++G+ + R ++ + A K +A P P
Sbjct: 232 RPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQ 291
Query: 284 --SIWL----AMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTG 337
S W A+++ F LL + ++D+ F P +S ++ + +
Sbjct: 292 EGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDP--------- 342
Query: 338 ISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILR 397
K Y+LAVL+FL+ LQ F Q + Y + LR A+ ++Y K+L
Sbjct: 343 -------KPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLA 395
Query: 398 LSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSAL 457
LS+ S +G + NLV+++ +L + LW V I++ + L+ LLG SAL
Sbjct: 396 LSSG--SRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSAL 453
Query: 458 VGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKS 517
AV + L P+ +FI+ K Q+ + R + T+ IL+ K +K + WE F
Sbjct: 454 TAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDR 513
Query: 518 VEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSL 577
V R +EL +L+T L S+S+ L F H + N + +AF +L++
Sbjct: 514 VLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTV 573
Query: 578 FHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGV 637
+IL L + V+A +S +L FL +E+ +SS + K
Sbjct: 574 LNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPG---VVDSSSSGSAAGKDCIT 630
Query: 638 VTNGYFSWGS-GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWS 696
+ + F+W L I++ +P G L +VG VG GKSSLL A+LGE+ +EG V
Sbjct: 631 IHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV--- 687
Query: 697 NVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQP 756
S E +VAY Q+ W+ N +V EN+ FG + + V +AC+LQP
Sbjct: 688 -------SIEG-------AVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQP 733
Query: 757 DIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQ 816
D+D P G T IGE+G+NLSGGQ+QR+ +ARA+Y+ + LDDP +ALD H+ H+
Sbjct: 734 DVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFN 793
Query: 817 EGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEH 873
+ I T +LVTH L L ADWII + +G++ G+ +++ + V L +
Sbjct: 794 QVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQ 853
Query: 874 WKTLMNRQDQELEKDMEADQ---TTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD- 929
+ +R + E E T+ R+ R S ++ + + E + E DD
Sbjct: 854 ARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDP 913
Query: 930 -------NMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 982
++ R K YL + G L + +F L + YWL+ W
Sbjct: 914 DRAGWPAGKDSIQYGRVKATVHLA--YLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLW 971
Query: 983 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMG-LTAAKNLHHNLLNKII 1041
+ ++ G+ Q G L G + L S+ +G A++ L LL ++
Sbjct: 972 ADDPAVG--GQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVV 1029
Query: 1042 LGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLV 1101
PI FF+ TP+G +LNRFS +T+ +D IP L SL L +++ ATP+ V
Sbjct: 1030 RSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATV 1089
Query: 1102 ALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF-KQ 1160
A+LPL + + Q + V+S L+ L+ ++ + H +ET +G T +RAFR + F Q
Sbjct: 1090 AILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ 1149
Query: 1161 RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSN--SGLVGLGLLY 1218
+ ++ I++ L A+RWL + LG +V A+ ++ ++ +GLVG +
Sbjct: 1150 NNARVDESQRISFPRL-VADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSA 1208
Query: 1219 ALTITNYLNWVVRNLADLEVQMGAVKKVNSFL-TMESENYEGTMDPSQVPEHWPQEGEIK 1277
AL +T L WVVRN DLE + +V+++ + T + + +Q P WPQ G+I+
Sbjct: 1209 ALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPP--WPQGGQIE 1266
Query: 1278 IHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVID 1337
D +RY L ++ V I G+KVGI GRTG+GKSSL+ R+ + +G I ID
Sbjct: 1267 FRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWID 1326
Query: 1338 GIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKS 1397
G+ I+ + LHTLRSR+SII QDPILF GS+R NLD + +D+ +W ALE QLK +V S
Sbjct: 1327 GVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVAS 1386
Query: 1398 LPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMT 1457
LPG L + GE+ SVGQ+QL CLARA +RK+ ILI+DEATA++D TE +Q ++ +
Sbjct: 1387 LPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGS 1446
Query: 1458 AFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1508
FA TV+ IAHR+ S+MD VLV +G + E + LLA K GLF L
Sbjct: 1447 WFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK-GLFYRL 1496
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 609 bits (1570), Expect = e-174
Identities = 429/1331 (32%), Positives = 669/1331 (50%), Gaps = 92/1331 (6%)
Query: 224 SKATYWWMNTLIISAHKKPI---DLKAIGKL----PIAMRAVTNYVCLKDAYEEQKKKVA 276
SKAT+WW++ L+ +++P+ DL ++G+ + R ++ + A K +A
Sbjct: 21 SKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIA 80
Query: 277 ---------DHPNRTP------SIWL----AMYRAFGRPILLSSTFRYLADLLGFAGPLC 317
P P S W A+++ F LL + ++D+ F P
Sbjct: 81 FKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKL 140
Query: 318 ISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTI 377
+S ++ + + K Y+LAVL+FL+ LQ F Q + Y
Sbjct: 141 LSLFLEFIGDP----------------KPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLK 184
Query: 378 ETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
+ LR A+ ++Y K+L LS+ S +G + NLV+++ +L + LW
Sbjct: 185 VLQMRLRSAITGLVYRKVLALSSG--SRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLP 242
Query: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
V I++ + L+ LLG SAL AV + L P+ +FI+ K Q+ + R + T+
Sbjct: 243 LVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSS 302
Query: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
IL+ K +K + WE F V R +EL +L+T L S+S+ L F
Sbjct: 303 ILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAV 362
Query: 558 HAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDD 617
H + N + +AF +L++ +IL L + V+A +S +L FL +E+
Sbjct: 363 HTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPG 422
Query: 618 SWRTGESSLPFESCKKHTGVVTNGYFSWGS-GLATLSNIDIRIPTGQLTMIVGQVGCGKS 676
+ +SS + K + + F+W L I++ +P G L +VG VG GKS
Sbjct: 423 AV---DSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKS 479
Query: 677 SLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITF 736
SLL A+LGE+ +EG V S E +VAY Q+ W+ N +V EN+ F
Sbjct: 480 SLLSALLGELSKVEGFV----------SIEG-------AVAYVPQEAWVQNTSVVENVCF 522
Query: 737 GSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNI 796
G + + V +AC+LQPD+D P G T IGE+G+NLSGGQ+QR+ +ARA+Y+ +
Sbjct: 523 GQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAV 582
Query: 797 VFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLR 856
LDDP +ALD H+ H+ + I T +LVTH L L ADWII + +G++
Sbjct: 583 YLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAE 642
Query: 857 EGTLKDIQTKD---VELYEHWKTLMNRQDQELEKDMEADQ---TTLERKTLRRAMYSREA 910
G+ +++ + V L + + +R + E E T+ R+ R S ++
Sbjct: 643 MGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKS 702
Query: 911 KAQMEDEDEEEEEEEDEDD--------NMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMI 962
+ + E + E DD ++ R K YL + G L + +
Sbjct: 703 VPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLA--YLRAVGTPLCLYAL 760
Query: 963 FSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVE 1022
F L + YWL+ W + ++ G+ Q G L G + L S+
Sbjct: 761 FLFLCQQVASFCRGYWLSLWADDPAVG--GQQTQAALRGGIFGLLGCLQAIGLFASMAAV 818
Query: 1023 WMG-LTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRS 1081
+G A++ L LL ++ PI FF+ TP+G +LNRFS +T+ +D IP L SL
Sbjct: 819 LLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMY 878
Query: 1082 TLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSE 1141
L +++ ATP+ VA+LPL + + Q + V+S L+ L+ ++ + H +E
Sbjct: 879 AFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAE 938
Query: 1142 TAEGLTTIRAFRHETRF-KQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASI 1200
T +G T +RAFR + F Q + ++ I++ L A+RWL + LG +V A+
Sbjct: 939 TFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRL-VADRWLAANVELLGNGLVFAAAT 997
Query: 1201 ASISGSSN--SGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFL-TMESENY 1257
++ ++ +GLVG + AL +T L WVVRN DLE + +V+++ + T + +
Sbjct: 998 CAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPW 1057
Query: 1258 EGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKS 1317
+Q P WPQ G+I+ D +RY L ++ V I G+KVGI GRTG+GKS
Sbjct: 1058 RLPTCAAQPP--WPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKS 1115
Query: 1318 SLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKC 1377
SL+ R+ + +G I IDG+ I+ + LHTLRSR+SII QDPILF GS+R NLD +
Sbjct: 1116 SLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEH 1175
Query: 1378 TDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMD 1437
+D+ +W ALE QLK +V SLPG L + GE+ SVGQ+QL CLARA +RK+ ILI+D
Sbjct: 1176 SDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILD 1235
Query: 1438 EATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNL 1497
EATA++D TE +Q ++ + FA TV+ IAHR+ S+MD VLV +G + E + L
Sbjct: 1236 EATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQL 1295
Query: 1498 LAHKNGLFSTL 1508
LA K GLF L
Sbjct: 1296 LAQK-GLFYRL 1305
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 558 bits (1437), Expect = e-158
Identities = 318/872 (36%), Positives = 493/872 (56%), Gaps = 43/872 (4%)
Query: 651 TLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRS 710
TL +ID+ I G+L I G VG GK+SL+ AILG+M LEG + S
Sbjct: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------- 623
Query: 711 RNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 770
+ AY AQ+ W+LNAT+ +NI FG ++++RY +V ++C L+PD+ +LP D TEIG
Sbjct: 624 ----TFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIG 679
Query: 771 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 830
ERG NLSGGQRQRI +ARALY + +I LDDP SALD H+ +H+ I K L+ +T+
Sbjct: 680 ERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKS--KTV 737
Query: 831 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDME 890
+ VTH+LQYL D +I MK+G + GT +++ + + + L+ + +E + +
Sbjct: 738 LFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSK 797
Query: 891 ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 950
+ + ++K+ + + K + + EE + + E+ +V PW Y+
Sbjct: 798 KETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSV-------PWSVYGVYI 850
Query: 951 TSGGFFLLILMIFSKLLKHSVIVAID-YWLATWTSEYSINNT-GKADQT----------- 997
+ G L L+I + + + A +WL+ W + S N T + ++T
Sbjct: 851 QAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPH 910
Query: 998 --YYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGL 1055
YY + +++ + L + + L A+ LH L +I+ P++FFDTTP G
Sbjct: 911 MQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGR 970
Query: 1056 ILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQK 1115
ILNRFS D + +D +P E ++ +L +GMI+ P FLVA+ PL + F +
Sbjct: 971 ILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHI 1030
Query: 1116 YFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLF 1175
RV ++L+ LD+ TQ P L H + + +GL TI A+ F R EL D N +
Sbjct: 1031 VSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFL 1090
Query: 1176 LSAANRWLEVRTDYLGACIVLTAS--IASISGSSNSGLVGLGLLYALTITNYLNWVVRNL 1233
+ A RWL VR D + ++ T I + G GL + YA+ +T + VR
Sbjct: 1091 FTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLA 1150
Query: 1234 ADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVL 1293
++ E + +V+++N ++ S + WPQEGE+ + +RY NL VL
Sbjct: 1151 SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVL 1210
Query: 1294 KHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRL 1353
K V IKP +K+GI GRTGSGKSSL +A FR+V++ G I IDG+ IS + L LRS+L
Sbjct: 1211 KKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKL 1270
Query: 1354 SIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENF 1413
SII Q+P+LFSG++R NLDP + T+D++W+ALE +K + LP L++ V E G+NF
Sbjct: 1271 SIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNF 1330
Query: 1414 SVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSS 1473
SVG+RQL C+ARA +R ILI+DEATA++D T+ ++Q+ + AFAD T++TIAHR+ +
Sbjct: 1331 SVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHT 1390
Query: 1474 IMDAGLVLVFSEGILVECDTVPNLLAHKNGLF 1505
++ + ++V ++G +VE DT LL++ + F
Sbjct: 1391 VLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
Score = 124 bits (311), Expect = 7e-28
Identities = 100/396 (25%), Positives = 195/396 (49%), Gaps = 28/396 (7%)
Query: 222 LLSKATYWWMNTLIISAHKK-PIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVA-DHP 279
L S T+ W+++L AHKK + ++ + L + N L+ ++E+ +V D
Sbjct: 106 LFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAA 165
Query: 280 NRTPSIWLAMYRAFGRP-ILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGI 338
+ +W+ F R ++LS + L GF+GP + +V+ + E T +
Sbjct: 166 SLRRVVWI-----FCRTRLILSIVCLMITQLAGFSGP---AFMVKHLLEYTQATESN--- 214
Query: 339 SETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRL 398
L+ + +L + L L I++ L ++ + TG+ LRGA+L M + KIL+L
Sbjct: 215 ---------LQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKL 265
Query: 399 STSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALV 458
++ E +LG++ N+ + + ++ + L PV I+G+I +LG + +
Sbjct: 266 K----NIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFL 321
Query: 459 GAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSV 518
G+AV +L P F + A ++ + + ER++K NE+L IK +K+YAW F +SV
Sbjct: 322 GSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSV 381
Query: 519 EETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLF 578
++ R +E L+ + S+++ + + + A + TF H G +L A+AF +++F
Sbjct: 382 QKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVH-MTLGFDLTAAQAFTVVTVF 440
Query: 579 HILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEI 614
+ + L + V+ +A ++V + L +E+
Sbjct: 441 NSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEV 476
Score = 81.3 bits (199), Expect = 7e-15
Identities = 60/221 (27%), Positives = 101/221 (45%), Gaps = 15/221 (6%)
Query: 1289 LKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHT 1348
L+ L + I+ G+ VGICG GSGK+SL A + + +G I I G
Sbjct: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG---------- 623
Query: 1349 LRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTE 1408
+ + Q + + ++R N+ + ++R L L+ + LP + E
Sbjct: 624 ---TFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
Query: 1409 GGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN-ILQKVVMTAFADRTVVTI 1467
G N S GQRQ LARA SI I+D+ +++D N I + +TV+ +
Sbjct: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFV 740
Query: 1468 AHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1508
H++ ++D V+ EG + E T L+ + NG ++T+
Sbjct: 741 THQLQYLVDCDEVIFMKEGCITERGTHEELM-NLNGDYATI 780
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 558 bits (1437), Expect = e-158
Identities = 388/1363 (28%), Positives = 669/1363 (49%), Gaps = 152/1363 (11%)
Query: 222 LLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNR 281
LLS AT+ W+ +++ +++ + + + L + TN + ++E+ +V P +
Sbjct: 51 LLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVG--PEK 108
Query: 282 TPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGP-LCISGIVQRVNETQNGTNNTTGISE 340
S+ +++ +L+ L ++ GP + I I+Q+ T G+
Sbjct: 109 A-SLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCI 167
Query: 341 TLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLST 400
L + EF + + F AL ++ + T I L+ AL +++ ++ T
Sbjct: 168 ALFATEFTK-------VFFWAL---------AWAINYRTAIRLKVALSTLVFENLVSFKT 211
Query: 401 SNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGA 460
+ +++G++ N+++ ++ L CP +P+ ++ + +LG +AL+G
Sbjct: 212 ----LTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGI 267
Query: 461 AVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEE 520
+V V+ P+Q F+A + ++S + + +R++ NE L I+L+K+YAWE F ++++
Sbjct: 268 SVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQD 327
Query: 521 TRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHI 580
R +E L+ S + + + A++ T H P AF+ +++F++
Sbjct: 328 IRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPV-AFSVIAMFNV 386
Query: 581 LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSD---------EIGDDSWRTGESSLPFES- 630
+ + +L ++ +A +S++++ + L+ E D ++L +E
Sbjct: 387 MKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHE 446
Query: 631 -----------------CKKHTGVVTNGYFSWGSGL-----------ATLSNIDIRIPTG 662
CKK + G + L +I + G
Sbjct: 447 ASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKG 506
Query: 663 QLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQK 722
++ I G VG GKSSLL A+LG+MQ +G V + ++AY +Q+
Sbjct: 507 KILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG-----------------TLAYVSQQ 549
Query: 723 PWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQ 782
W+ + V ENI FG ++ QRY+ C LQ D+ LP+GD TEIGERG+NLSGGQRQ
Sbjct: 550 AWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQ 609
Query: 783 RICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTH 842
RI +ARA+Y + + LDDP SA+D H+ H+ +E I K L+ +T+VLVTH+LQ+L
Sbjct: 610 RISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRG--KTVVLVTHQLQFLES 667
Query: 843 ADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLR 902
D +I ++DG + +GT K++ E + K + N + + KD E + +
Sbjct: 668 CDEVILLEDGEICEKGTHKELME---ERGRYAKLIHNLRGLQF-KDPEHLYNAAMVEAFK 723
Query: 903 RAMYSREAKAQM------EDEDEEEEEE---EDEDDNMSTVMRLRTKMP------WKTCW 947
+ RE A + ++DE +E E E D + ++T+ P WKT
Sbjct: 724 ESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYH 783
Query: 948 RYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSIL 1006
Y+ SGG+ L + +F LL ++WL W + S G G +
Sbjct: 784 TYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQ-------GNRTM 836
Query: 1007 CGAGIFLCLVTSLTVEWM----------------------GLTAAKNLHHNLLNKIILGP 1044
C G L + +W+ L A+ +LH + +KI+ P
Sbjct: 837 CEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSP 896
Query: 1045 IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL 1104
+ FFDTTP G ++NRFS D + +D +P E+ + + + + +++ P L+ +
Sbjct: 897 MSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVA 956
Query: 1105 PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE 1164
L V F+ + + F ++L+++++ ++ P H + + +GL I A+ + E
Sbjct: 957 SLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKK--------E 1008
Query: 1165 LTDTNNIAYLFLSAANRWLEVRTDYL------GACIVLTASIASISGSSNSGLVGLGLLY 1218
T ++ L+ + A RW +R D L +++T S +SIS SS GL L Y
Sbjct: 1009 SCITYHL--LYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSK----GLSLSY 1062
Query: 1219 ALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKI 1278
+ ++ L VR + + + +V+ + +++ + P+ WP GEI
Sbjct: 1063 IIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITF 1122
Query: 1279 HDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDG 1338
D +RY +N VL + I+ GQ VGI GRTGSGKSSL +A FR+V+ G I ID
Sbjct: 1123 RDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDE 1182
Query: 1339 IDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSL 1398
+DI L L LR++L++I QDP+LF G++R+NLDP TD+ LW+ LE +++ + L
Sbjct: 1183 VDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKL 1242
Query: 1399 PGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTA 1458
P L A VTE GENFSVG+RQL C+ARA +R S I+++DEATAS+D T+ ++Q + A
Sbjct: 1243 PEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDA 1302
Query: 1459 FADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHK 1501
F TV+TIAHR++++++ VLV G ++E D P +LA K
Sbjct: 1303 FKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDK-PEVLAEK 1344
Score = 84.3 bits (207), Expect = 8e-16
Identities = 56/224 (25%), Positives = 107/224 (47%), Gaps = 15/224 (6%)
Query: 1287 NNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1346
++LK VL + ++ G+ +GICG GSGKSSL A + + G + ++G
Sbjct: 490 DSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG-------- 541
Query: 1347 HTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVV 1406
L+ + Q +F G++R N+ K R + + L+ + +LP G +
Sbjct: 542 -----TLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEI 596
Query: 1407 TEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKVVMTAFADRTVV 1465
E G N S GQRQ LARA + ++D+ +++D +++ ++ + +TVV
Sbjct: 597 GERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVV 656
Query: 1466 TIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
+ H++ + V++ +G + E T L+ + G ++ L+
Sbjct: 657 LVTHQLQFLESCDEVILLEDGEICEKGTHKELM-EERGRYAKLI 699
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 553 bits (1424), Expect = e-157
Identities = 405/1387 (29%), Positives = 659/1387 (47%), Gaps = 148/1387 (10%)
Query: 204 PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249
PP D +R + PF L S T W+ L+I + + +D I
Sbjct: 59 PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118
Query: 250 KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309
L + + N L +EE+ V+ S+ L M R ++ + +
Sbjct: 119 PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175
Query: 310 LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369
GP+ I + +E Q G N G+ L LFL+ ++
Sbjct: 176 ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220
Query: 370 QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429
+S+ + T I R A+ + + K+++ S+ +T G+ + + N L +
Sbjct: 221 SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276
Query: 430 LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489
P + +++ I Y ++G +A + +L+ P+ F+ +AQ T + S
Sbjct: 277 YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336
Query: 490 ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549
+R++ T+E+L IKL+K+Y WE F K +E+ R KE L+ L SL+ IP
Sbjct: 337 QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396
Query: 550 AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609
A + H L + AF+ L+ ++L +F + V+ + +V + +F
Sbjct: 397 ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455
Query: 610 LSDE--IGDDSWRTGESSLPFESC-----KKHTGVVT-------NGYFSWG--------- 646
L + + + +L FE + G+V NG+ S G
Sbjct: 456 LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALG 515
Query: 647 ------SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNE 700
S L I++ + G + + G G GKSSLL AIL EM LEG V
Sbjct: 516 PEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG--- 572
Query: 701 SEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDL 760
S+AY Q+ W+++ + ENI G ++K RY V CSL D++L
Sbjct: 573 --------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLEL 618
Query: 761 LPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGIL 820
LPFGD TEIGERG+NLSGGQ+QRI +ARA+Y + I LDDP SA+D H+ H+ +E I
Sbjct: 619 LPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIK 678
Query: 821 KFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNR 880
K L+ +T+VLVTH+LQYL II +++G + GT ++ K + + L+ +
Sbjct: 679 KTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGK----YAQLIQK 732
Query: 881 QDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEEEEEEEDEDDNMS 932
+E DM D + K + S+ +E+ E + +EEE E+ ++S
Sbjct: 733 MHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLS 789
Query: 933 TVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNT 991
W+ Y+ +GG+ + ++ F +L + + +WL+ W + S N+
Sbjct: 790 ----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNS 839
Query: 992 GKADQ---------------TYY--VAGFSIL-------CGAGIFLCLVTSLTVEWMGLT 1027
+ ++Y V G + L C +GIF T +T +
Sbjct: 840 SRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF----TKVTRK----- 890
Query: 1028 AAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLS 1087
A+ LH+ L NK+ P+ FFDT P+G +LN F+ D +DQ +P E +L+ ++
Sbjct: 891 ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIA 950
Query: 1088 AIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLT 1147
+ ++S +P L+ + V + F+ A + L++ ++ PL H + +GL+
Sbjct: 951 VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLS 1010
Query: 1148 TIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSS 1207
+I + F + LTD N L ++ RW+ +R + + + L ++ G S
Sbjct: 1011 SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGIS 1070
Query: 1208 NS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQ 1265
++ + + L + + R + E Q AV+++ ++ M M+ +
Sbjct: 1071 STPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTS 1130
Query: 1266 VPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFR 1325
P+ WPQ GEI D ++Y +N VL + I+ + VGI GRTGSGKSSL +A FR
Sbjct: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190
Query: 1326 MVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEA 1385
+V+ G+I+IDG+DI + L LRS+LS+I QDP+L SG+IRFNLDP + TD ++W+A
Sbjct: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDA 1250
Query: 1386 LEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM 1445
LE L + P L V E G NFSVG+RQL C+ARA +R S I+++DEATASIDM
Sbjct: 1251 LERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDM 1310
Query: 1446 ATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNG-L 1504
T+ ++Q+ + AF TV+ IAHRV+++++ +LV G +VE D P +L K G L
Sbjct: 1311 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR-PEVLRKKPGSL 1369
Query: 1505 FSTLVMT 1511
F+ L+ T
Sbjct: 1370 FAALMAT 1376
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 553 bits (1424), Expect = e-157
Identities = 405/1387 (29%), Positives = 659/1387 (47%), Gaps = 148/1387 (10%)
Query: 204 PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249
PP D +R + PF L S T W+ L+I + + +D I
Sbjct: 59 PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118
Query: 250 KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309
L + + N L +EE+ V+ S+ L M R ++ + +
Sbjct: 119 PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175
Query: 310 LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369
GP+ I + +E Q G N G+ L LFL+ ++
Sbjct: 176 ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220
Query: 370 QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429
+S+ + T I R A+ + + K+++ S+ +T G+ + + N L +
Sbjct: 221 SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276
Query: 430 LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489
P + +++ I Y ++G +A + +L+ P+ F+ +AQ T + S
Sbjct: 277 YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336
Query: 490 ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549
+R++ T+E+L IKL+K+Y WE F K +E+ R KE L+ L SL+ IP
Sbjct: 337 QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396
Query: 550 AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609
A + H L + AF+ L+ ++L +F + V+ + +V + +F
Sbjct: 397 ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455
Query: 610 LSDE--IGDDSWRTGESSLPFESC-----KKHTGVVT-------NGYFSWG--------- 646
L + + + +L FE + G+V NG+ S G
Sbjct: 456 LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALG 515
Query: 647 ------SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNE 700
S L I++ + G + + G G GKSSLL AIL EM LEG V
Sbjct: 516 PEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG--- 572
Query: 701 SEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDL 760
S+AY Q+ W+++ + ENI G ++K RY V CSL D++L
Sbjct: 573 --------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLEL 618
Query: 761 LPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGIL 820
LPFGD TEIGERG+NLSGGQ+QRI +ARA+Y + I LDDP SA+D H+ H+ +E I
Sbjct: 619 LPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIK 678
Query: 821 KFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNR 880
K L+ +T+VLVTH+LQYL II +++G + GT ++ K + + L+ +
Sbjct: 679 KTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGK----YAQLIQK 732
Query: 881 QDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEEEEEEEDEDDNMS 932
+E DM D + K + S+ +E+ E + +EEE E+ ++S
Sbjct: 733 MHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLS 789
Query: 933 TVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNT 991
W+ Y+ +GG+ + ++ F +L + + +WL+ W + S N+
Sbjct: 790 ----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNS 839
Query: 992 GKADQ---------------TYY--VAGFSIL-------CGAGIFLCLVTSLTVEWMGLT 1027
+ ++Y V G + L C +GIF T +T +
Sbjct: 840 SRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF----TKVTRK----- 890
Query: 1028 AAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLS 1087
A+ LH+ L NK+ P+ FFDT P+G +LN F+ D +DQ +P E +L+ ++
Sbjct: 891 ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIA 950
Query: 1088 AIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLT 1147
+ ++S +P L+ + V + F+ A + L++ ++ PL H + +GL+
Sbjct: 951 VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLS 1010
Query: 1148 TIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSS 1207
+I + F + LTD N L ++ RW+ +R + + + L ++ G S
Sbjct: 1011 SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGIS 1070
Query: 1208 NS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQ 1265
++ + + L + + R + E Q AV+++ ++ M M+ +
Sbjct: 1071 STPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTS 1130
Query: 1266 VPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFR 1325
P+ WPQ GEI D ++Y +N VL + I+ + VGI GRTGSGKSSL +A FR
Sbjct: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190
Query: 1326 MVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEA 1385
+V+ G+I+IDG+DI + L LRS+LS+I QDP+L SG+IRFNLDP + TD ++W+A
Sbjct: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDA 1250
Query: 1386 LEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM 1445
LE L + P L V E G NFSVG+RQL C+ARA +R S I+++DEATASIDM
Sbjct: 1251 LERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDM 1310
Query: 1446 ATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNG-L 1504
T+ ++Q+ + AF TV+ IAHRV+++++ +LV G +VE D P +L K G L
Sbjct: 1311 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR-PEVLRKKPGSL 1369
Query: 1505 FSTLVMT 1511
F+ L+ T
Sbjct: 1370 FAALMAT 1376
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 502 bits (1292), Expect = e-141
Identities = 390/1387 (28%), Positives = 639/1387 (46%), Gaps = 186/1387 (13%)
Query: 204 PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249
PP D +R + PF L S T W+ L+I + + +D I
Sbjct: 59 PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118
Query: 250 KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309
L + + N L +EE+ V+ S+ L M R ++ + +
Sbjct: 119 PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175
Query: 310 LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369
GP+ I + +E Q G N G+ L LFL+ ++
Sbjct: 176 ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220
Query: 370 QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429
+S+ + T I R A+ + + K+++ S+ +T G+ + + N L +
Sbjct: 221 SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276
Query: 430 LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489
P + +++ I Y ++G +A + +L+ P+ F+ +AQ T + S
Sbjct: 277 YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336
Query: 490 ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549
+R++ T+E+L IKL+K+Y WE F K +E+ R KE L+ L SL+ IP
Sbjct: 337 QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396
Query: 550 AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609
A + H L + AF+ L+ ++L +F + V+ + +V + +F
Sbjct: 397 ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455
Query: 610 LSDE--IGDDSWRTGESSLPFESC-----KKHTGVVT-------NGYFSWG--------- 646
L + + + +L FE + G+V NG+ S G
Sbjct: 456 LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALG 515
Query: 647 ------SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNE 700
S L I++ + G + + G G GKSSLL AIL EM LEG V
Sbjct: 516 PEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG--- 572
Query: 701 SEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDL 760
S+AY Q+ W+++ + ENI G ++K RY V CSL D++L
Sbjct: 573 --------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLEL 618
Query: 761 LPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGIL 820
LPFGD TEIGERG+NLSGGQ+QRI +ARA+Y + I LDDP SA+D H+ H+ +E I
Sbjct: 619 LPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIK 678
Query: 821 KFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNR 880
K L+ +T+VLVTH+LQYL II +++G + GT ++ K + + L+ +
Sbjct: 679 KTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGK----YAQLIQK 732
Query: 881 QDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEEEEEEEDEDDNMS 932
+E DM D + K + S+ +E+ E + +EEE E+ ++S
Sbjct: 733 MHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLS 789
Query: 933 TVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNT 991
W+ Y+ +GG+ + ++ F +L + + +WL+ W + S N+
Sbjct: 790 ----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNS 839
Query: 992 GKADQ---------------TYY--VAGFSIL-------CGAGIFLCLVTSLTVEWMGLT 1027
+ ++Y V G + L C +GIF T +T +
Sbjct: 840 SRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF----TKVTRK----- 890
Query: 1028 AAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLS 1087
A+ LH+ L NK+ P+ FFDT P+G +LN F+ D +DQ +P E +L+ ++
Sbjct: 891 ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIA 950
Query: 1088 AIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLT 1147
+ ++S +P L+ + V + F+ A + L++ ++ PL H + +GL+
Sbjct: 951 VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLS 1010
Query: 1148 TIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSS 1207
+I + F + LTD N L ++ RW+ +R + + + L ++ G S
Sbjct: 1011 SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGIS 1070
Query: 1208 NS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQ 1265
++ + + L + + R + E Q AV+++ ++ M M+ +
Sbjct: 1071 STPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTS 1130
Query: 1266 VPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFR 1325
P+ WPQ GEI D ++Y +N VL + I+ + VGI GRTGSGKSSL +A FR
Sbjct: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190
Query: 1326 MVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEA 1385
+V+ G+I+IDG+DI + L LRS+LS+I QDP+L SG+IRFNLDP + TD ++W+A
Sbjct: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDA 1250
Query: 1386 LEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM 1445
LE R F+ K+ ILI DEATASIDM
Sbjct: 1251 LE-------------------------------------RTFLTKAIILI-DEATASIDM 1272
Query: 1446 ATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNG-L 1504
T+ ++Q+ + AF TV+ IAHRV+++++ +LV G +VE D P +L K G L
Sbjct: 1273 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR-PEVLRKKPGSL 1331
Query: 1505 FSTLVMT 1511
F+ L+ T
Sbjct: 1332 FAALMAT 1338
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 495 bits (1274), Expect = e-139
Identities = 280/772 (36%), Positives = 447/772 (57%), Gaps = 46/772 (5%)
Query: 772 RGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQ-----EGILKFLQDD 826
+G+NLSGGQ+QR+ +ARA+Y N +I DDP SA+D H+ H+ + +G+LK
Sbjct: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK----- 759
Query: 827 KRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQEL 885
+T +LVTH + YL D II M G + G+ +++ +D E +T + Q+Q+
Sbjct: 760 NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDA 819
Query: 886 EKD---------MEADQTT------------LERKTLRRAMYSREAKAQMEDEDEEEEEE 924
E++ EA Q L+R+ + YS + E ++ E
Sbjct: 820 EENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAE 879
Query: 925 EDEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLAT 981
+++ M ++ W Y+ + G F+ L IF + H +A +YWL+
Sbjct: 880 AKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSL 939
Query: 982 WTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLN 1038
WT + +N T Q + S+ GI + S+ V G+ A++ LH +LL+
Sbjct: 940 WTDDPIVNGT----QEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLH 995
Query: 1039 KIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPV 1098
I+ P+ FF+ TP G ++NRFS + + +D IP ++ S + A +I ATP+
Sbjct: 996 SILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPI 1055
Query: 1099 FLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF 1158
+ + PLG+ ++F+Q+++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF
Sbjct: 1056 AAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERF 1115
Query: 1159 KQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGL 1216
+ D N AY ANRWL VR + +G CIVL A++ ++ S ++GLVGL +
Sbjct: 1116 IHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSV 1175
Query: 1217 LYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEI 1276
Y+L +T YLNW+VR +++E + AV+++ + E E + + P WPQ G +
Sbjct: 1176 SYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRV 1234
Query: 1277 KIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1336
+ + C+RY +L VL+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+I
Sbjct: 1235 EFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIII 1294
Query: 1337 DGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVK 1396
DGI+I+K+ LH LR +++II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V
Sbjct: 1295 DGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVS 1354
Query: 1397 SLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVM 1456
+LP LD EGGEN SVGQRQL CLARA +RK+ IL++DEATA++D+ T++++Q +
Sbjct: 1355 ALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIR 1414
Query: 1457 TAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1508
T F D TV+TIAHR+++IMD V+V +G + E P+ L + GLF ++
Sbjct: 1415 TQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG-APSDLLQQRGLFYSM 1465
Score = 232 bits (592), Expect = 2e-60
Identities = 163/518 (31%), Positives = 256/518 (49%), Gaps = 58/518 (11%)
Query: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
Query: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
Query: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
Query: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
Query: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWG-SGLATLSNIDIRIPTGQ 663
L FL +E+ DS E + ++ V N F+W S TL+ I IP G
Sbjct: 616 LRIFLSHEELEPDSI---ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGA 672
Query: 664 LTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNES 701
L +VGQVGCGKSSLL A+L EM +EG V VN S
Sbjct: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLS 710
Score = 95.5 bits (236), Expect = 3e-19
Identities = 105/447 (23%), Positives = 198/447 (44%), Gaps = 39/447 (8%)
Query: 437 MPVQIIMGVILLYNLLGSSALVG-----AAVIVLLAPIQYFIATKLAEAQKSTLDYSTER 491
+P I M + L+N++G+ ++ AA+I+ + YF + A L E
Sbjct: 1028 IPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLK-RLES 1086
Query: 492 LKKT------NEILKGIKLLKLYAWEHIFCKS----VEETRMKELSSLKTFA-LYTSLSI 540
+ ++ NE L G+ +++ + + F V+E + S+ L L
Sbjct: 1087 VSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1146
Query: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKA-- 598
N + AA+ A H+ ++G LS+ + L +L + +VR + +
Sbjct: 1147 VGNCIVLFAALFAVISRHSLSAG--------LVGLSVSYSLQVTTYL-NWLVRMSSEMET 1197
Query: 599 -IISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLA-TLSNID 656
I++V++L E+ S+ + W+ E++ P + N + L L +I+
Sbjct: 1198 NIVAVERLKEY--SETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHIN 1255
Query: 657 IRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSV 716
+ I G+ IVG+ G GKSSL L + ++ EG++ +N ++ R + +
Sbjct: 1256 VTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLR----FKI 1311
Query: 717 AYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINL 776
Q P L + ++ N+ S ++ + + L+ + LP E E G NL
Sbjct: 1312 TIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1371
Query: 777 SGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHK 836
S GQRQ +C+ARAL + T I+ LD+ +A+D+ +D L+Q I +D T++ + H+
Sbjct: 1372 SVGQRQLVCLARALLRKTKILVLDEATAAVDLE-TDDLIQSTIRTQFED--CTVLTIAHR 1428
Query: 837 LQYLTHADWIIAMKDGSVLREGTLKDI 863
L + +I + G + G D+
Sbjct: 1429 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1455
Score = 52.0 bits (123), Expect = 4e-06
Identities = 102/479 (21%), Positives = 185/479 (38%), Gaps = 71/479 (14%)
Query: 898 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 953
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
Query: 954 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1009
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
Query: 1010 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1063
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 1064 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1116
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
Query: 1117 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1171
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
Query: 1172 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1227
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 1228 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1283
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
Query: 1284 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDIS 1342
+ + P L + I G V + G+ G GKSSL A +D +G + I G+++S
Sbjct: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLS 710
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 446 bits (1148), Expect = e-125
Identities = 254/711 (35%), Positives = 408/711 (57%), Gaps = 36/711 (5%)
Query: 828 RTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQELE 886
+T +LVTH + YL D II M G + G+ +++ +D E +T + Q+Q+ E
Sbjct: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
Query: 887 KD---------MEADQTT------------LERKTLRRAMYSREAKAQMEDEDEEEEEEE 925
++ EA Q L+R+ + YS + E ++ E
Sbjct: 765 ENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 824
Query: 926 DEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 982
+++ M ++ W Y+ + G F+ L IF + H +A +YWL+ W
Sbjct: 825 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLW 884
Query: 983 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLNK 1039
T + +N T Q + S+ GI + S+ V G+ A++ LH +LL+
Sbjct: 885 TDDPIVNGT----QEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 940
Query: 1040 IILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVF 1099
I+ P+ FF+ TP G ++NRFS + + +D IP ++ S + A +I ATP+
Sbjct: 941 ILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIA 1000
Query: 1100 LVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFK 1159
+ + PLG+ ++F+Q+++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF
Sbjct: 1001 AIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFI 1060
Query: 1160 QRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGLL 1217
+ D N AY ANRWL VR + +G CIVL A++ ++ S ++GLVGL +
Sbjct: 1061 HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVS 1120
Query: 1218 YALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIK 1277
Y+L +T YLNW+VR +++E + AV+++ + E E + + P WPQ G ++
Sbjct: 1121 YSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVE 1179
Query: 1278 IHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVID 1337
+ C+RY +L VL+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+ID
Sbjct: 1180 FRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIID 1239
Query: 1338 GIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKS 1397
GI+I+K+ LH LR +++II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V +
Sbjct: 1240 GINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSA 1299
Query: 1398 LPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMT 1457
LP LD EGGEN SVGQRQL CLARA +RK+ IL++DEATA++D+ T++++Q + T
Sbjct: 1300 LPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRT 1359
Query: 1458 AFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1508
F D TV+TIAHR+++IMD V+V +G + E P+ L + GLF ++
Sbjct: 1360 QFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG-APSDLLQQRGLFYSM 1409
Score = 230 bits (586), Expect = 9e-60
Identities = 160/510 (31%), Positives = 253/510 (49%), Gaps = 58/510 (11%)
Query: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
Query: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
Query: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
Query: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
Query: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWG-SGLATLSNIDIRIPTGQ 663
L FL +E+ DS E + ++ V N F+W S TL+ I IP G
Sbjct: 616 LRIFLSHEELEPDSI---ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGA 672
Query: 664 LTMIVGQVGCGKSSLLLAILGEMQTLEGKV 693
L +VGQVGCGKSSLL A+L EM +EG V
Sbjct: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHV 702
Score = 95.5 bits (236), Expect = 3e-19
Identities = 105/447 (23%), Positives = 198/447 (44%), Gaps = 39/447 (8%)
Query: 437 MPVQIIMGVILLYNLLGSSALVG-----AAVIVLLAPIQYFIATKLAEAQKSTLDYSTER 491
+P I M + L+N++G+ ++ AA+I+ + YF + A L E
Sbjct: 972 IPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLK-RLES 1030
Query: 492 LKKT------NEILKGIKLLKLYAWEHIFCKS----VEETRMKELSSLKTFA-LYTSLSI 540
+ ++ NE L G+ +++ + + F V+E + S+ L L
Sbjct: 1031 VSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1090
Query: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKA-- 598
N + AA+ A H+ ++G LS+ + L +L + +VR + +
Sbjct: 1091 VGNCIVLFAALFAVISRHSLSAG--------LVGLSVSYSLQVTTYL-NWLVRMSSEMET 1141
Query: 599 -IISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLA-TLSNID 656
I++V++L E+ S+ + W+ E++ P + N + L L +I+
Sbjct: 1142 NIVAVERLKEY--SETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHIN 1199
Query: 657 IRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSV 716
+ I G+ IVG+ G GKSSL L + ++ EG++ +N ++ R + +
Sbjct: 1200 VTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLR----FKI 1255
Query: 717 AYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINL 776
Q P L + ++ N+ S ++ + + L+ + LP E E G NL
Sbjct: 1256 TIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1315
Query: 777 SGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHK 836
S GQRQ +C+ARAL + T I+ LD+ +A+D+ +D L+Q I +D T++ + H+
Sbjct: 1316 SVGQRQLVCLARALLRKTKILVLDEATAAVDLE-TDDLIQSTIRTQFED--CTVLTIAHR 1372
Query: 837 LQYLTHADWIIAMKDGSVLREGTLKDI 863
L + +I + G + G D+
Sbjct: 1373 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1399
Score = 46.2 bits (108), Expect = 2e-04
Identities = 100/473 (21%), Positives = 180/473 (38%), Gaps = 71/473 (15%)
Query: 898 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 953
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
Query: 954 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1009
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
Query: 1010 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1063
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 1064 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1116
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
Query: 1117 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1171
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
Query: 1172 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1227
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 1228 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1283
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
Query: 1284 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1336
+ + P L + I G V + G+ G GKSSL A +D +G + I
Sbjct: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 365 bits (937), Expect = e-100
Identities = 268/907 (29%), Positives = 451/907 (49%), Gaps = 78/907 (8%)
Query: 200 QKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVT 259
Q+VKP LQD NL S+ +WW+N L HK+ ++ + + R+
Sbjct: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
Query: 260 NYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCIS 319
L+ ++++ + A++ + PS+ A+ + + + L+ F + + P+ +
Sbjct: 56 LGEELQGFWDKEVLR-AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
Query: 320 GIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLA-VLLFLALILQRTFLQASYYVTIE 378
I+ N N + L AY A VL F LIL L Y+ ++
Sbjct: 115 KII-------NYFENYDPMDSVA-----LNTAYAYATVLTFCTLIL--AILHHLYFYHVQ 160
Query: 379 -TGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
G+ LR A+ MIY K LRLS N++MG+ T GQI NL++ + N+ LWA
Sbjct: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
Query: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
P+Q I LL+ +G S L G AV+++L P+Q + + T ++ R++ NE
Sbjct: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
Query: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
++ GI+++K+YAWE F + R KE+S + + +++ + V TF T
Sbjct: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
Query: 558 HAYASGNNLKPAEAFASLSLFHI--LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIG 615
+ G+ + + F +++L+ L LF S + R + +AI+S++++ FLL DEI
Sbjct: 339 YVLL-GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVS-EAIVSIRRIQTFLLLDEIS 396
Query: 616 DDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGK 675
+ LP + K ++ S TL + + G+L +VG VG GK
Sbjct: 397 QRN-----RQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
Query: 676 SSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENIT 735
SSLL A+LGE+ G V + R +AY +Q+PW+ + T+ NI
Sbjct: 452 SSLLSAVLGELAPSHGLV-------------SVHGR----IAYVSQQPWVFSGTLRSNIL 494
Query: 736 FGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTN 795
FG + K+RY+ V AC+L+ D+ LL GD T IG+RG LSGGQ+ R+ +ARA+YQ+ +
Sbjct: 495 FGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDAD 554
Query: 796 IVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVL 855
I LDDP SA+D +S HL + I + L + + +LVTH+LQYL A I+ +KDG ++
Sbjct: 555 IYLLDDPLSAVDAEVSRHLFELCICQILHE--KITILVTHQLQYLKAASQILILKDGKMV 612
Query: 856 REGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMY--SREAKAQ 913
++GT + ++ + +L+ + ++E E+ TL +T + + ++
Sbjct: 613 QKGTYTEFLKSGID----FGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPS 668
Query: 914 MEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIV 973
++D E ++ E+ +S R K+ ++ Y +G + I+ IF LL + V
Sbjct: 669 LKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHW--IVFIFLILLNTAAQV 726
Query: 974 AI---DYWLATWTSEYSI---------NNTGKADQTYYVAGFSILCGAGIFLCLVTSLTV 1021
A D+WL+ W ++ S+ N T K D +Y+ +S L A + + SL V
Sbjct: 727 AYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLV 786
Query: 1022 EWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPT-LESLTR 1080
++ + +++ LH+ + I+ P+ FFD P+G ILNRFS D +D +P T L+ + R
Sbjct: 787 FYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQR 846
Query: 1081 STLLCLS 1087
L LS
Sbjct: 847 WDLAVLS 853
Score = 87.4 bits (215), Expect = 9e-17
Identities = 103/502 (20%), Positives = 212/502 (42%), Gaps = 53/502 (10%)
Query: 1021 VEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQ-----HI--PP 1073
V+ G+ + H + K + T G I+N S D N DQ H
Sbjct: 159 VQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
Query: 1074 TLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQL 1133
L+++ + LL + IG+ A L+ LLPL F + R + + T
Sbjct: 219 PLQAIAVTALLWME-IGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM- 276
Query: 1134 PLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGAC 1193
+E G+ I+ + E F + L I+ + S+ R + + + + +
Sbjct: 277 ------NEVITGIRIIKMYAWEKSFSNLITNLRK-KEISKILRSSCLRGMNLASFFSASK 329
Query: 1194 IVLTASIAS-------ISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKV 1246
I++ + + I+ S V L LT+T + + +++ V +++++
Sbjct: 330 IIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIV---SIRRI 386
Query: 1247 NSFLTMESENYEGTMDPSQVPEHWPQEGEIKIH--DLCVRYENNLK-PVLKHVKAYIKPG 1303
+FL ++ + SQ P +G+ +H D ++ + P L+ + ++PG
Sbjct: 387 QTFLLLD--------EISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPG 438
Query: 1304 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILF 1363
+ + + G G+GKSSL A + G + + G R++ + Q P +F
Sbjct: 439 ELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWVF 485
Query: 1364 SGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCL 1423
SG++R N+ K +R + ++ LK ++ L G V+ + G S GQ+ L
Sbjct: 486 SGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNL 545
Query: 1424 ARAFVRKSSILIMDEATASIDM-ATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLV 1482
ARA + + I ++D+ +++D + ++ + + ++ + + H++ + A +L+
Sbjct: 546 ARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILI 605
Query: 1483 FSEGILVECDTVPNLLAHKNGL 1504
+G +V+ T L K+G+
Sbjct: 606 LKDGKMVQKGTYTEFL--KSGI 625
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 285 bits (728), Expect = 3e-76
Identities = 190/648 (29%), Positives = 327/648 (50%), Gaps = 45/648 (6%)
Query: 891 ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 950
A Q L + S+E ++ +E EE+ +E D+M ++ + T W T RY+
Sbjct: 797 APQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTT---WNTYLRYI 853
Query: 951 T--SGGFFLLI--LMIFSKLLKHSVIVAIDYWLATWT-------SEYSINNTGK----AD 995
T F+LI L+IF + S++V WL T S +S NN+ +
Sbjct: 854 TVHKSLIFVLIWCLVIFLAEVAASLVVL---WLLGNTPLQDKGNSTHSRNNSYAVIITST 910
Query: 996 QTYYVAGFSILCGAGIFLCLV---TSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTP 1052
+YYV F I G L + L + +T +K LHH +L+ ++ P+ +T
Sbjct: 911 SSYYV--FYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
Query: 1053 LGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYF 1112
G ILNRFS D I+D +P T+ + L+ + AI +++ P VA +P+ VAF
Sbjct: 969 AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
Query: 1113 IQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA 1172
++ YF S+ L++L+ + P+ H + +GL T+RAF + F+ + + +
Sbjct: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
Query: 1173 YLFLSAANRWLEVRTDYLGACIVLTASIASI-SGSSNSGLVGLGLLYALTITNYLNWVVR 1231
+ + RW ++R + + + + SI + G VG+ L A+ I + L W V
Sbjct: 1089 WFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVN 1148
Query: 1232 NLADLEVQMGAVKKVNSFLTMESENY---------EGTMDPSQVPEH--------WPQEG 1274
+ D++ M +V +V F+ M +E G + + E+ WP G
Sbjct: 1149 SSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGG 1208
Query: 1275 EIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKI 1334
++ + DL +Y +L+++ I PGQ+VG+ GRTGSGKS+L AF R+++ +G+I
Sbjct: 1209 QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEI 1267
Query: 1335 VIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNM 1394
IDG+ + L R +I Q +FSG+ R NLDP + +D +W+ + L+++
Sbjct: 1268 QIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSV 1327
Query: 1395 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 1454
++ PG LD V+ +GG S G +QL CLAR+ + K+ IL++DE +A +D T I+++
Sbjct: 1328 IEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRT 1387
Query: 1455 VMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKN 1502
+ AFAD TV+ HR+ ++++ LV E + + D++ LL ++
Sbjct: 1388 LKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
Score = 216 bits (551), Expect = 1e-55
Identities = 178/674 (26%), Positives = 321/674 (47%), Gaps = 79/674 (11%)
Query: 221 NLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYE-EQKKKVADHP 279
+++SK + W ++ +++ ++L I ++P +V + L + E E +++A
Sbjct: 10 SVVSKLFFSWTRPILRKGYRQRLELSDIYQIP----SVDSADNLSEKLEREWDRELASKK 65
Query: 280 NRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGIS 339
N P + A+ R F + F YL ++ PL + I+ +
Sbjct: 66 N--PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDP------------ 111
Query: 340 ETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLS 399
+KE A L + L L I++ L + + G+ +R A+ ++IY K L+LS
Sbjct: 112 ---DNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLS 168
Query: 400 TSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVG 459
+ L ++++GQ+ +L++ N+ L L +W P+Q+ + + L++ LL +SA G
Sbjct: 169 SRVLD--KISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCG 226
Query: 460 AAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVE 519
+++LA Q + + + + +ERL T+E+++ I+ +K Y WE K +E
Sbjct: 227 LGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIE 286
Query: 520 ETRMKELSSLK--TFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSL 577
R EL + + Y + S F + + V + + +A G L+ + F ++S
Sbjct: 287 NLRQTELKLTRKAAYVRYFNSSAFFFSGFFV--VFLSVLPYALIKGIILR--KIFTTISF 342
Query: 578 FHIL---VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDS---------------- 618
+L VT F V+ ++ ++ K+ +FL E
Sbjct: 343 CIVLRMAVTRQF--PWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAF 400
Query: 619 WRTGESSLPFESCKKHTG--VVTNG----YFSWGSGLAT--LSNIDIRIPTGQLTMIVGQ 670
W G L FE K++ +NG +FS S L T L +I+ +I GQL + G
Sbjct: 401 WEEGFGEL-FEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGS 459
Query: 671 VGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATV 730
G GK+SLL+ I+GE++ EGK+ S +++ +Q W++ T+
Sbjct: 460 TGAGKTSLLMVIMGELEPSEGKIKHSG-----------------RISFCSQFSWIMPGTI 502
Query: 731 EENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARAL 790
+ENI FG +++ RY++V AC L+ DI D +GE GI LSGGQR RI +ARA+
Sbjct: 503 KENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAV 562
Query: 791 YQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMK 850
Y++ ++ LD PF LD+ + + + K + + +T +LVT K+++L AD I+ +
Sbjct: 563 YKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMAN--KTRILVTSKMEHLKKADKILILH 620
Query: 851 DGSVLREGTLKDIQ 864
+GS GT ++Q
Sbjct: 621 EGSSYFYGTFSELQ 634
Score = 79.7 bits (195), Expect = 2e-14
Identities = 83/377 (22%), Positives = 152/377 (40%), Gaps = 47/377 (12%)
Query: 1140 SETAEGLTTIRAFRHETRFKQ-----RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACI 1194
SE E + +++A+ E ++ R EL T AY+ ++ + + +
Sbjct: 263 SEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSV 322
Query: 1195 VLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFL---- 1250
+ A I I + ++ + +T W V+ D +GA+ K+ FL
Sbjct: 323 LPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQE 379
Query: 1251 --TMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK------------------ 1290
T+E + V W +EG ++ + + NN K
Sbjct: 380 YKTLEYNLTTTEVVMENVTAFW-EEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGT 438
Query: 1291 PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLR 1350
PVLK + I+ GQ + + G TG+GK+SL + ++ +GKI G
Sbjct: 439 PVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------ 486
Query: 1351 SRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGG 1410
R+S Q + G+I+ N+ + R ++ QL+ + + V+ EGG
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 1411 ENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE-NILQKVVMTAFADRTVVTIAH 1469
S GQR LARA + + + ++D +D+ TE I + V A++T + +
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 1470 RVSSIMDAGLVLVFSEG 1486
++ + A +L+ EG
Sbjct: 606 KMEHLKKADKILILHEG 622
Score = 70.9 bits (172), Expect = 9e-12
Identities = 70/309 (22%), Positives = 133/309 (43%), Gaps = 32/309 (10%)
Query: 616 DDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGK 675
DD W +G + K T T G G A L NI I GQ ++G+ G GK
Sbjct: 1201 DDIWPSGGQM----TVKDLTAKYTEG------GNAILENISFSISPGQRVGLLGRTGSGK 1250
Query: 676 SSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENIT 735
S+LL A L + T EG++ V+ + + R + QK ++ + T +N+
Sbjct: 1251 STLLSAFLRLLNT-EGEIQIDGVSWDSITLQQWRK----AFGVIPQKVFIFSGTFRKNLD 1305
Query: 736 FGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTN 795
++ Q V D L+ I+ P + + G LS G +Q +C+AR++
Sbjct: 1306 PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAK 1365
Query: 796 IVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVL 855
I+ LD+P + LD ++ +++ + + D T++L H+++ + + +++ V
Sbjct: 1366 ILLLDEPSAHLD-PVTYQIIRRTLKQAFAD--CTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 856 REGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQME 915
+ Y+ + L+N + + +D+ L S+ A ++
Sbjct: 1423 Q--------------YDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALK 1468
Query: 916 DEDEEEEEE 924
+E EEE ++
Sbjct: 1469 EETEEEVQD 1477
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 224 bits (570), Expect = 6e-58
Identities = 234/912 (25%), Positives = 413/912 (45%), Gaps = 83/912 (9%)
Query: 640 NGYFSWGSG--LATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSN 697
N +FS+ S + L +++++ +GQ +VG GCGKS+ + + EG V
Sbjct: 396 NVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDG 455
Query: 698 VNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQ 755
+ + R + +Q+P L T+ ENI +G + + KAV +A +
Sbjct: 456 QDIRTINVRFLRE----IIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEA-NAY 510
Query: 756 PDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLM 815
I LP T +GERG LSGGQ+QRI +ARAL +N I+ LD+ SALD S+ ++
Sbjct: 511 DFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAVV 569
Query: 816 QEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWK 875
Q + K + RT +++ H+L + +AD I DG ++ +G ++ K+ +Y
Sbjct: 570 QVALDKARKG--RTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLV 626
Query: 876 TLMNRQDQELEKDMEADQTTLE-----------RKTLRRAMYSREAKAQMEDEDEEEEEE 924
T M E+E + AD++ E R +L R +R + + +D + +
Sbjct: 627 T-MQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTK 685
Query: 925 EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLI--------LMIFSKLLKHSVIVAID 976
E D+++ V R T W Y G F +I +IFSK++ V ID
Sbjct: 686 EALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKII--GVFTRID 743
Query: 977 YWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNL 1036
T + + + F L + T G K L + +
Sbjct: 744 D-----------PETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMV 792
Query: 1037 LNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQHIPPTLESLTRS-----TLLCLSAI 1089
++ + +FD G + R + D + I L +T++ T + +S I
Sbjct: 793 FRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFI 852
Query: 1090 GMISYATPVFLVALLPL-GVAFYFIQKYFR-VASKDLQELDDSTQLPLLCHFSETAEGLT 1147
+ + L+A++P+ +A K A KD +EL+ S ++ +E E
Sbjct: 853 --YGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIA-----TEAIENFR 905
Query: 1148 TIRAFRHETRFKQ---RMLELTDTNNI--AYLF-LSAANRWLEVRTDYLGACIVLTASIA 1201
T+ + E +F+ + L++ N++ A++F ++ + + Y G C A +
Sbjct: 906 TVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAG-CFRFGAYLV 964
Query: 1202 S--ISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMG-AVKKVNSFLTMESENYE 1258
+ + + LV +++ ++ + A ++ + + ++S + E
Sbjct: 965 AHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTE 1024
Query: 1259 GTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK-PVLKHVKAYIKPGQKVGICGRTGSGKS 1317
G M P+ + EG + ++ Y PVL+ + +K GQ + + G +G GKS
Sbjct: 1025 GLM-PNTL------EGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKS 1077
Query: 1318 SLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNL---DPE 1374
++ R D GK+++DG +I +L + LR+ L I+ Q+PILF SI N+ D
Sbjct: 1078 TVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNS 1137
Query: 1375 CKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSIL 1434
+ + + A + A + ++SLP V + G S GQ+Q +ARA VR+ IL
Sbjct: 1138 RVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHIL 1197
Query: 1435 IMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTV 1494
++DEAT+++D +E ++Q+ + A RT + IAHR+S+I +A L++VF G + E T
Sbjct: 1198 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTH 1257
Query: 1495 PNLLAHKNGLFS 1506
LLA K FS
Sbjct: 1258 QQLLAQKGIYFS 1269
Score = 127 bits (320), Expect = 6e-29
Identities = 77/257 (29%), Positives = 133/257 (51%), Gaps = 15/257 (5%)
Query: 1255 ENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGS 1314
+N +G ++ V +P E+KI LK + ++ GQ V + G +G
Sbjct: 386 DNIKGNLEFRNVHFSYPSRKEVKI--------------LKGLNLKVQSGQTVALVGNSGC 431
Query: 1315 GKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-P 1373
GKS+ R+ D +G + +DG DI + + LR + ++ Q+P+LF+ +I N+
Sbjct: 432 GKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYG 491
Query: 1374 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1433
T D + +A++ A + + LP D +V E G S GQ+Q +ARA VR I
Sbjct: 492 RENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKI 551
Query: 1434 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDT 1493
L++DEAT+++D +E ++Q + A RT + IAHR+S++ +A ++ F +G++VE
Sbjct: 552 LLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGN 611
Query: 1494 VPNLLAHKNGLFSTLVM 1510
L+ K F + M
Sbjct: 612 HDELMKEKGIYFKLVTM 628
Score = 104 bits (260), Expect = 6e-22
Identities = 130/558 (23%), Positives = 233/558 (41%), Gaps = 52/558 (9%)
Query: 318 ISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQR-TFLQASYYVT 376
I G+ R+++ + N+ L S FL L ++ F+ LQ TF +A +T
Sbjct: 735 IIGVFTRIDDPETKRQNSN-----LFSLLFL----ALGIISFITFFLQGFTFGKAGEILT 785
Query: 377 IETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFL-----FLC 431
L M++ +LR S + T G + +A + Q+ + +
Sbjct: 786 KR--------LRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVIT 837
Query: 432 PNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYS--- 488
N+ + II+ I + L L +I + ++ + + A K L+ S
Sbjct: 838 QNIANLGTGIIISFIYGWQLT-LLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKI 896
Query: 489 -TERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIP 547
TE ++ + + L + +EH++ +S++ L F + S + A+
Sbjct: 897 ATEAIENFRTV---VSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFT----QAMM 949
Query: 548 IAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFA---VKAIISVQK 604
+ F AY + L E L +F +V + V FA KA IS
Sbjct: 950 YFSYAGCFRFGAYLVAHKLMSFEDV--LLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAH 1007
Query: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLATLSNIDIRIPTGQL 664
+ + + D G E VV N + + L + + + GQ
Sbjct: 1008 IIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFN--YPTRPDIPVLQGLSLEVKKGQT 1065
Query: 665 TMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPW 724
+VG GCGKS+++ + L GKV + + R+ + +Q+P
Sbjct: 1066 LALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAH----LGIVSQEPI 1121
Query: 725 LLNATVEENITFGSPFNKQRYKAVTDAC---SLQPDIDLLPFGDQTEIGERGINLSGGQR 781
L + ++ ENI +G + + A ++ I+ LP T++G++G LSGGQ+
Sbjct: 1122 LFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQK 1181
Query: 782 QRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLT 841
QRI +ARAL + +I+ LD+ SALD S+ ++QE + K + RT +++ H+L +
Sbjct: 1182 QRIAIARALVRQPHILLLDEATSALDTE-SEKVVQEALDK--AREGRTCIVIAHRLSTIQ 1238
Query: 842 HADWIIAMKDGSVLREGT 859
+AD I+ ++G V GT
Sbjct: 1239 NADLIVVFQNGRVKEHGT 1256
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 214 bits (544), Expect = 7e-55
Identities = 225/926 (24%), Positives = 411/926 (44%), Gaps = 118/926 (12%)
Query: 642 YFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 699
+FS+ S + L +++++ +GQ +VG GCGKS+ + I EG ++
Sbjct: 400 HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDG-- 457
Query: 700 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPD 757
+ +F R V +Q+P L + T+ ENI +G + + KAV +A + +
Sbjct: 458 QDIRNFNVNYLREIIGVV--SQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE-F 514
Query: 758 IDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE 817
I LP T +GERG LSGGQ+QRI +ARAL +N I+ LD+ SALD S+ +Q
Sbjct: 515 IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAEVQA 573
Query: 818 GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHW 874
+ K + RT +++ H+L + +AD I +DG ++ +G+ ++ K+ +L
Sbjct: 574 ALDKAREG--RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
Query: 875 KTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----N 930
+ Q +E E + E T + + ++ + +++ ++ + E D N
Sbjct: 632 TSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEAN 691
Query: 931 MSTVMRLRTKMPWKTCWRY--------LTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 982
+ V L+ KT W Y + +GG +IFS+ I+AI
Sbjct: 692 VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSE------IIAI------- 738
Query: 983 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK-------NLHHN 1035
G D +I +FL +++ T G T K L
Sbjct: 739 --------FGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSM 790
Query: 1036 LLNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMIS 1093
++ + +FD G + R + D + Q T +L + L +IS
Sbjct: 791 AFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALIAQNIANLGTGIIIS 849
Query: 1094 YA----TPVFLVALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLT 1147
+ + L+A++P+ ++ A +D +EL+ + ++ +E E +
Sbjct: 850 FIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIA-----TEAIENIR 904
Query: 1148 TIRAFRHETRFKQRMLE-----------------LTDTNNIAYLFLSAANRWLEVRTDYL 1190
T+ + E +F+ +E +T + + A+++ S A +
Sbjct: 905 TVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFR------F 958
Query: 1191 GACIVLTA-----SIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKK 1245
GA +++ + + + G V LG +A + + A L +
Sbjct: 959 GAYLIVNGHMRFRDVILVFSAIVFGAVALG--HASSFAPDYAKAKLSAAHLFMLFERQPL 1016
Query: 1246 VNSFLT--MESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPG 1303
++S+ ++ + +EG + ++V ++P + PVL+ + +K G
Sbjct: 1017 IDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV--------------PVLQGLSLEVKKG 1062
Query: 1304 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILF 1363
Q + + G +G GKS++ R D G +++DG + KL + LR++L I+ Q+PILF
Sbjct: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILF 1122
Query: 1364 SGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQL 1420
SI N+ D + D + A + A + +++LP + V + G S GQ+Q
Sbjct: 1123 DCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQR 1182
Query: 1421 FCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLV 1480
+ARA +R+ IL++DEAT+++D +E ++Q+ + A RT + IAHR+S+I +A L+
Sbjct: 1183 IAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLI 1242
Query: 1481 LVFSEGILVECDTVPNLLAHKNGLFS 1506
+VF G + E T LLA K FS
Sbjct: 1243 VVFQNGRVKEHGTHQQLLAQKGIYFS 1268
Score = 125 bits (314), Expect = 3e-28
Identities = 79/240 (32%), Positives = 134/240 (55%), Gaps = 5/240 (2%)
Query: 1273 EGEIKIHDLCVRYEN--NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIF 1330
+G ++ +D+ Y + N+K +LK + ++ GQ V + G +G GKS+ R+ D
Sbjct: 391 KGNLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD 449
Query: 1331 DGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIA 1389
+G I IDG DI ++ LR + ++ Q+P+LFS +I N+ T D + +A++ A
Sbjct: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
Query: 1390 QLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN 1449
+ LP D +V E G S GQ+Q +ARA VR IL++DEAT+++D +E
Sbjct: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
Query: 1450 ILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
+Q + A RT + IAHR+S++ +A ++ F +G++VE + L+ K G++ LV
Sbjct: 570 EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 207 bits (526), Expect = 8e-53
Identities = 225/933 (24%), Positives = 411/933 (44%), Gaps = 125/933 (13%)
Query: 642 YFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 699
+FS+ S + L +++++ +GQ +VG GCGKS+ + I EG ++
Sbjct: 400 HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDG-- 457
Query: 700 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPD 757
+ +F R V +Q+P L + T+ ENI +G + + KAV +A + +
Sbjct: 458 QDIRNFNVNYLREIIGVV--SQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE-F 514
Query: 758 IDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE 817
I LP T +GERG LSGGQ+QRI +ARAL +N I+ LD+ SALD S+ +Q
Sbjct: 515 IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAEVQA 573
Query: 818 GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHW 874
+ K + RT +++ H+L + +AD I +DG ++ +G+ ++ K+ +L
Sbjct: 574 ALDKAREG--RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
Query: 875 KTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----N 930
+ Q +E E + E T + + ++ + +++ ++ + E D N
Sbjct: 632 TSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEAN 691
Query: 931 MSTVMRLRTKMPWKTCWRY--------LTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 982
+ V L+ KT W Y + +GG +IFS+ I+AI
Sbjct: 692 VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSE------IIAI------- 738
Query: 983 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK-------NLHHN 1035
G D +I +FL +++ T G T K L
Sbjct: 739 --------FGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSM 790
Query: 1036 LLNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMIS 1093
++ + +FD G + R + D + Q T +L + L +IS
Sbjct: 791 AFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALIAQNIANLGTGIIIS 849
Query: 1094 YA----TPVFLVALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLT 1147
+ + L+A++P+ ++ A +D +EL+ + ++ +E E +
Sbjct: 850 FIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIA-----TEAIENIR 904
Query: 1148 TIRAFRHETRFKQRMLE-----------------LTDTNNIAYLFLSAANRWLEVRTDYL 1190
T+ + E +F+ +E +T + + A+++ S A +
Sbjct: 905 TVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFR------F 958
Query: 1191 GACIVLTA-----SIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKK 1245
GA +++ + + + G V LG +A + + A L +
Sbjct: 959 GAYLIVNGHMRFRDVILVFSAIVFGAVALG--HASSFAPDYAKAKLSAAHLFMLFERQPL 1016
Query: 1246 VNSFLT--MESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPG 1303
++S+ ++ + +EG + ++V ++P + PVL+ + +K G
Sbjct: 1017 IDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV--------------PVLQGLSLEVKKG 1062
Query: 1304 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKI-------VIDGIDISKLPLHTLRSRLSII 1356
Q + + G +G GKS++ R D G + ++DG + KL + LR++L I+
Sbjct: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIV 1122
Query: 1357 LQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENF 1413
Q+PILF SI N+ D + D + A + A + +++LP + V + G
Sbjct: 1123 SQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQL 1182
Query: 1414 SVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSS 1473
S GQ+Q +ARA +R+ IL++DEAT+++D +E ++Q+ + A RT + IAHR+S+
Sbjct: 1183 SGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1242
Query: 1474 IMDAGLVLVFSEGILVECDTVPNLLAHKNGLFS 1506
I +A L++VF G + E T LLA K FS
Sbjct: 1243 IQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFS 1275
Score = 125 bits (314), Expect = 3e-28
Identities = 79/240 (32%), Positives = 134/240 (55%), Gaps = 5/240 (2%)
Query: 1273 EGEIKIHDLCVRYEN--NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIF 1330
+G ++ +D+ Y + N+K +LK + ++ GQ V + G +G GKS+ R+ D
Sbjct: 391 KGNLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD 449
Query: 1331 DGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIA 1389
+G I IDG DI ++ LR + ++ Q+P+LFS +I N+ T D + +A++ A
Sbjct: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
Query: 1390 QLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN 1449
+ LP D +V E G S GQ+Q +ARA VR IL++DEAT+++D +E
Sbjct: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
Query: 1450 ILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
+Q + A RT + IAHR+S++ +A ++ F +G++VE + L+ K G++ LV
Sbjct: 570 EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 199 bits (505), Expect = 2e-50
Identities = 224/914 (24%), Positives = 392/914 (42%), Gaps = 89/914 (9%)
Query: 652 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 711
L+++++ I G++T +VG G GKS+ L I EG V + + + R +
Sbjct: 438 LNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQ 497
Query: 712 NRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEI 769
+ Q+P L + T+ ENI +G + +A +A + +DL P T +
Sbjct: 498 ----IGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDL-PQQFDTLV 552
Query: 770 GERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRT 829
GE G +SGGQ+QR+ +ARAL +N I+ LD SALD + S+ ++QE + K T
Sbjct: 553 GEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSKIQHG--HT 609
Query: 830 LVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKD- 888
++ V H+L + AD II + G+ + GT +++ + +Y TL ++ +Q L ++
Sbjct: 610 IISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERK-GVYFTLVTLQSQGNQALNEED 668
Query: 889 -MEADQTTLERKTLRRAMYSREAKAQMEDE-----------------DEEEEEEEDEDDN 930
+A + + +T R Y +A + D + EED D
Sbjct: 669 IKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDK 728
Query: 931 MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINN 990
V P + ++ ++L+ + + +V + + +SI +
Sbjct: 729 DIPVQEEVEPAPVRRILKFSAPEWPYMLVGSV-GAAVNGTVTPLYAFLFSQILGTFSIPD 787
Query: 991 TGKADQTYYVAGFSILCGA----GIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIR 1046
K +Q + G +L A +F + G K L ++ I
Sbjct: 788 --KEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIA 845
Query: 1047 FFDT--TPLGLILNRFSADTNIID----QHIPPTLESLTRSTLLCLSAIGMISYATPVFL 1100
+FD G + R + D + + I + S T T+ + A S+ + +
Sbjct: 846 WFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSF-SWKLSLVI 904
Query: 1101 VALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF 1158
+ P Q AS+D Q L+ Q+ +E + T+ E RF
Sbjct: 905 LCFFPFLALSGATQTRMLTGFASRDKQALEMVGQIT-----NEALSNIRTVAGIGKERRF 959
Query: 1159 KQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLY 1218
+E +T L + + + G C I I+ S++ G
Sbjct: 960 ----IEALETE------LEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGY---- 1005
Query: 1219 ALTITN---YLNWVVRNLADLEVQMGAVKKVNSFLT------MESENYEGTMDP------ 1263
I+N + ++V R ++ + + A+ + S+ + + + +D
Sbjct: 1006 --LISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISV 1063
Query: 1264 -SQVPEHWPQ-EGEIKIHDLCVRYENNL-KPVLKHVKAYIKPGQKVGICGRTGSGKSSLS 1320
+ E W +G+I D Y + VL + I PGQ + G +G GKS+
Sbjct: 1064 YNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSI 1123
Query: 1321 LAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNL---DPECKC 1377
R D GK++IDG D K+ + LRS + I+ Q+P+LF+ SI N+ D +
Sbjct: 1124 QLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEI 1183
Query: 1378 TDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMD 1437
+R+ A + AQL + V SLP + V G S G++Q +ARA VR IL++D
Sbjct: 1184 PMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLD 1243
Query: 1438 EATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNL 1497
EAT+++D +E +Q + A RT + IAHR+S+I +A ++ V ++G+++E T L
Sbjct: 1244 EATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEEL 1303
Query: 1498 LAHKNGLFSTLVMT 1511
+A K G + LV T
Sbjct: 1304 MAQK-GAYYKLVTT 1316
Score = 134 bits (337), Expect = 7e-31
Identities = 79/239 (33%), Positives = 134/239 (56%), Gaps = 3/239 (1%)
Query: 1273 EGEIKIHDLCVRYENNLK-PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFD 1331
+GEI+ H++ Y + + +L + IKPG+ + G +G+GKS+ R D +
Sbjct: 417 KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCE 476
Query: 1332 GKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECK-CTDDRLWEALEIAQ 1390
G + +DG DI L + LR ++ I+ Q+P+LFS +I N+ + T + + +A + A
Sbjct: 477 GMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEAN 536
Query: 1391 LKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENI 1450
N + LP D +V EGG S GQ+Q +ARA +R IL++D AT+++D +E +
Sbjct: 537 AYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAM 596
Query: 1451 LQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
+Q+V+ T++++AHR+S++ A ++ F G VE T LL K G++ TLV
Sbjct: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERK-GVYFTLV 654
Score = 94.4 bits (233), Expect = 8e-19
Identities = 94/393 (23%), Positives = 165/393 (41%), Gaps = 35/393 (8%)
Query: 495 TNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLAT 554
TNE L I+ + E F +++E K KT ++ F A +A
Sbjct: 940 TNEALSNIRTVAGIGKERRFIEALETELEKPF---KTAIQKANIYGFCFAFAQCIMFIAN 996
Query: 555 FVTHAYA----SGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLL 610
++ Y S L + F +S + T L + KA IS + + L
Sbjct: 997 SASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLD 1056
Query: 611 SD------EIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWGS--GLATLSNIDIRIPTG 662
+ W + + F CK F++ S L+ + + I G
Sbjct: 1057 RQPPISVYNTAGEKWDNFQGKIDFVDCK----------FTYPSRPDSQVLNGLSVSISPG 1106
Query: 663 QLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQK 722
Q VG GCGKS+ + + +GKV + + + + RS ++ +Q+
Sbjct: 1107 QTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRS----NIGIVSQE 1162
Query: 723 PWLLNATVEENITFGSPFNK---QRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGG 779
P L ++ +NI +G + +R A L + LP +T +G +G LS G
Sbjct: 1163 PVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRG 1222
Query: 780 QRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQY 839
++QRI +ARA+ ++ I+ LD+ SALD S+ +Q + K + RT +++ H+L
Sbjct: 1223 EKQRIAIARAIVRDPKILLLDEATSALDTE-SEKTVQVALDK--AREGRTCIVIAHRLST 1279
Query: 840 LTHADWIIAMKDGSVLREGTLKDIQTKDVELYE 872
+ +AD I M G V+ +GT +++ + Y+
Sbjct: 1280 IQNADIIAVMAQGVVIEKGTHEELMAQKGAYYK 1312
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 190 bits (482), Expect = 1e-47
Identities = 197/823 (23%), Positives = 363/823 (44%), Gaps = 65/823 (7%)
Query: 713 RYSVAYAAQKPWLLNATVEENITFGSP--FNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 770
R + +Q+P L T+ NI +G +++ +A +A + ++ P T +G
Sbjct: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEF-PNKFNTLVG 74
Query: 771 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 830
E+G +SGGQ+QRI +ARAL +N I+ LD+ SALD S +Q + K + RT
Sbjct: 75 EKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKG--RTT 131
Query: 831 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDME 890
++V H+L + AD I+ +KDG + +G ++ K Y +M++ ++ ++ ME
Sbjct: 132 IVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYS---LVMSQDIKKADEQME 188
Query: 891 ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 950
+ + ERKT ++S ++ + + D+ EE + ++ ++ V L+ K W ++
Sbjct: 189 SMTYSTERKTNSLPLHSVKS-IKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFV 247
Query: 951 TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINN--TGKADQTYYVAGFSILCG 1008
G + +L +V A + + N+ T K D Y F IL
Sbjct: 248 VLG--------TLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGV 299
Query: 1009 AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDT--TPLGLILNRFSADTNI 1066
+ L G L H ++ I +FD G + + D
Sbjct: 300 ICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQ 359
Query: 1067 IDQHIPPTLESLTRS-TLLCLSAIGMISYATPV--FLVALLPLGVAFYFIQKYFRV--AS 1121
I + LT++ T + LS I Y + ++++ P+ I+ A+
Sbjct: 360 IQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFAN 419
Query: 1122 KDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANR 1181
KD QEL + ++ +E E + TI + E F+Q E+ T + R
Sbjct: 420 KDKQELKHAGKIA-----TEALENIRTIVSLTREKAFEQMYEEMLQTQH----------R 464
Query: 1182 WLEVRTDYLGACIVLTASIASISGSSN----------SGLVGLGLLYALTITNYLNWVVR 1231
+ +G+C + + + ++ + G+ T Y +
Sbjct: 465 NTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIG 524
Query: 1232 NLADLEVQMGAVKK--VNSFLTMESE-NYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENN 1288
L + K + F +E + N + + P+ EG ++ ++ Y
Sbjct: 525 ETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTC--EGNLEFREVSFFYP-- 580
Query: 1289 LKP---VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLP 1345
+P +L+ + I+ G+ V G +G GKS+ R+ D G+++ DG+D +L
Sbjct: 581 CRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELN 640
Query: 1346 LHTLRSRLSIILQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGL 1402
+ LRS+++I+ Q+P+LF+ SI N+ D D + EA A + + ++ LP
Sbjct: 641 VQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKY 700
Query: 1403 DAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADR 1462
+ V G S GQ+Q +ARA ++K IL++DEAT+++D +E ++Q + A R
Sbjct: 701 NTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGR 760
Query: 1463 TVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLF 1505
T + + HR+S+I +A L++V G + E T LL +++ F
Sbjct: 761 TCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYF 803
Score = 108 bits (271), Expect = 3e-23
Identities = 129/532 (24%), Positives = 233/532 (43%), Gaps = 53/532 (9%)
Query: 353 VLAVLLFLALILQRTFL-QASYYVTIETGINLRG-ALLAMIYNKILRLSTSNLSMGEMTL 410
+L V+ F++ +Q F +A +T+ LR A AM+Y I S G +T
Sbjct: 296 ILGVICFVSYFMQGLFYGRAGEILTMR----LRHLAFKAMLYQDIAWFDEKENSTGGLTT 351
Query: 411 GQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQ 470
++ I+ L N M + +I+ I + + + A V+ + I+
Sbjct: 352 ILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSI-APVLAVTGMIE 410
Query: 471 YFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEET-RMKELSSL 529
T A K L ++ K E L+ I+ + E F + EE + + ++
Sbjct: 411 TAAMTGFANKDKQELKHAG---KIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTS 467
Query: 530 KTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTP--LFL 587
K + S F +A F+ AYA+G F + + +TP +F+
Sbjct: 468 KKAQIIGSCYAFSHA----------FIYFAYAAGFR------FGAYLIQAGRMTPEGMFI 511
Query: 588 LSTVVRFAVKAIISVQKL------------NEFLLSDEIGDDSWRTGESSLPFESCKKHT 635
+ T + + AI L + F L ++ + R+ E P ++C+ +
Sbjct: 512 VFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKP-DTCEGNL 570
Query: 636 GVVTNGYF-SWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVH 694
+F + L + + I G+ VG GCGKS+ + + ++G+V
Sbjct: 571 EFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVL 630
Query: 695 WSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNK---QRYKAVTDA 751
+ V+ E + + RS+ +A Q+P L N ++ ENI +G K +A
Sbjct: 631 FDGVDAKELNVQWLRSQ----IAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANA 686
Query: 752 CSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLS 811
++ I+ LP T++G +G LSGGQ+QR+ +ARAL Q I+ LD+ SALD + S
Sbjct: 687 ANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALD-NDS 745
Query: 812 DHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDI 863
+ ++Q + K RT ++VTH+L + +AD I+ + +G + +GT +++
Sbjct: 746 EKVVQHALDK--ARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQEL 795
Score = 100 bits (250), Expect = 8e-21
Identities = 58/178 (32%), Positives = 97/178 (54%), Gaps = 2/178 (1%)
Query: 1335 VIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIAQLKN 1393
++D DI L + R + ++ Q+P+LF +I N+ TD+ + A A +
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
Query: 1394 MVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQK 1453
+ P + +V E G S GQ+Q +ARA VR ILI+DEAT+++D +++ +Q
Sbjct: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
Query: 1454 VVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMT 1511
+ A RT + +AHR+S+I A L++ +G+L E L+A K GL+ +LVM+
Sbjct: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMA-KRGLYYSLVMS 177
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B isoform
1 [Homo sapiens]
Length = 703
Score = 161 bits (407), Expect = 5e-39
Identities = 147/580 (25%), Positives = 267/580 (46%), Gaps = 36/580 (6%)
Query: 921 EEEEEDEDDNMSTVMRL----RTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAID 976
+E+E+D+ +N + RL R +P L + FFL++ ++ L+ H ID
Sbjct: 125 QEKEQDQVNNKVLMWRLLKLSRPDLP------LLVAAFFFLVLAVLGETLIPHYSGRVID 178
Query: 977 YWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNL 1036
+ + + + S C G F ++ + + + L
Sbjct: 179 ILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLR---------IREQL 229
Query: 1037 LNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIG-MISYA 1095
+ ++ + FF T G + +R S+DT ++ +P L RS + + G M+S +
Sbjct: 230 FSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSIS 289
Query: 1096 TPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHE 1155
+ L++LL + + Y + L+E+ D+ E GL T+R+F E
Sbjct: 290 PRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQV-VREAVGGLQTVRSFGAE 348
Query: 1156 TRFKQRMLELTDTNNIAYLF--LSAANRWLEVRTDYLGA-CIVLTASIASIS-GSSNSGL 1211
R E + Y L A L R +LG ++L+ + + G G
Sbjct: 349 EHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGS 408
Query: 1212 VGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE-NYEGTMDPSQVPEHW 1270
+ ++Y ++ +Y+ +V D+ +GA +KV S++ + GT+ P+ +
Sbjct: 409 LLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTL---- 464
Query: 1271 PQEGEIKIHDLCVRYENNL-KPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDI 1329
+G +K D+ Y N +PVLK + ++PG+ + G GSGKS+++ +
Sbjct: 465 --QGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQP 522
Query: 1330 FDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECK-CTDDRLWEALEI 1388
G++++D IS+ L S++ + Q+P+LFSGS+R N+ + C DD++ A +
Sbjct: 523 TGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQA 582
Query: 1389 AQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE 1448
A + ++ + G+ V E G + GQ+Q +ARA VR +LI+DEAT+++D+ E
Sbjct: 583 AHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
Query: 1449 NILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGIL 1488
LQ + DRTV+ IAHR+ ++ A +LV EG L
Sbjct: 643 QALQD--WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
Score = 84.7 bits (208), Expect = 6e-16
Identities = 54/214 (25%), Positives = 104/214 (48%), Gaps = 10/214 (4%)
Query: 652 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 711
L + + G++T +VG G GKS++ + Q G+V + + +P +
Sbjct: 486 LKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV----LLDEKPISQYEHCY 541
Query: 712 NRYSVAYAAQKPWLLNATVEENITFG-SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 770
V Q+P L + +V NI +G + A A I + G T++G
Sbjct: 542 LHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVG 601
Query: 771 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 830
E+G L+ GQ+QR+ +ARAL ++ ++ LD+ SALD+ ++ + + RT+
Sbjct: 602 EKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQ-----CEQALQDWNSRGDRTV 656
Query: 831 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 864
+++ H+LQ + A I+ +++G + + L++ Q
Sbjct: 657 LVIAHRLQAVQRAHQILVLQEGKLQKLAQLQEGQ 690
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 159 bits (401), Expect = 3e-38
Identities = 136/537 (25%), Positives = 243/537 (45%), Gaps = 61/537 (11%)
Query: 1009 AGIFLC-----LVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1063
+ +FLC + ++ G L +L + I+ + FFD T G ++NR S+D
Sbjct: 219 SAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSD 278
Query: 1064 TNIIDQHIPPTLESLTRSTLLCLSAIGMISYATP---VFLVALLP-LGVAFYFIQKYFRV 1119
T ++ + + L R+ I M+ + +P F+++++P + + +Y R
Sbjct: 279 TALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRK 338
Query: 1120 ASKDLQE-LDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSA 1178
+K Q+ L +TQL E + T+RAF E M E+ + +
Sbjct: 339 LTKVTQDSLAQATQLA-----EERIGNVRTVRAFGKE------MTEIEKYASKVDHVMQL 387
Query: 1179 ANRWLEVRTDYLGAC------IVLTASIAS--ISGSSNS--GLVGLGLLYALTITNYLNW 1228
A + R + GA IVL+ + GS++ G + L+YA + +
Sbjct: 388 ARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGG 447
Query: 1229 VVRNLADLEVQMGAVKKV------------NSFLTMESENYEGTMDPSQVPEHWPQEGEI 1276
+ ++L +GA ++ N + + ++++G ++ V +P E+
Sbjct: 448 LSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEV 507
Query: 1277 KIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1336
P+ + I G + G +GSGKS++ R+ D G I +
Sbjct: 508 --------------PIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISL 553
Query: 1337 DGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNL----DPECKCTDDRLWEALEIAQLK 1392
DG DI +L LRS++ + Q+PILFS SI N+ D T + + E+A
Sbjct: 554 DGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAV 613
Query: 1393 NMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQ 1452
+++ P G + VV E G S GQ+Q +ARA ++ IL++DEAT+++D E ++Q
Sbjct: 614 AFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQ 673
Query: 1453 KVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
+ + RTV+ IAHR+S+I +A +V V +G + E LL+ NG++ L+
Sbjct: 674 EALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLM 730
Score = 107 bits (266), Expect = 1e-22
Identities = 68/232 (29%), Positives = 125/232 (53%), Gaps = 14/232 (6%)
Query: 654 NIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNR 713
+ + IP+G +T +VG G GKS++L +L G + + + + RS+
Sbjct: 512 DFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSK-- 569
Query: 714 YSVAYAAQKPWLLNATVEENITFG----SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEI 769
+ +Q+P L + ++ ENI +G S + + V + + I P G T +
Sbjct: 570 --IGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVV 627
Query: 770 GERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRT 829
GE+G+ LSGGQ+QRI +ARAL +N I+ LD+ SALD +++L+QE + + + D RT
Sbjct: 628 GEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEALDRLM--DGRT 684
Query: 830 LVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQ 881
++++ H+L + +A+ + + G + G +++ +K +Y + LMN+Q
Sbjct: 685 VLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIY---RKLMNKQ 733
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 150 bits (378), Expect = 1e-35
Identities = 131/510 (25%), Positives = 219/510 (42%), Gaps = 64/510 (12%)
Query: 71 LRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGF-VATTTSIVYYHNIE-TS 128
L W +++A LF + G R + P V+G + T ++ Y ++
Sbjct: 79 LLWCVSWADLFYSFHGLVHG------RAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQ 132
Query: 129 NFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCI--TGMMVILNGLLMAVEIN 186
+ L++ FL V A + K++ G RF ++L+ L++A
Sbjct: 133 SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILAC--- 189
Query: 187 VIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLK 246
R F + + V P + + LS+ +WW + I ++ P++ K
Sbjct: 190 ---FREKPPFFSAKNVDPNP--------YPETSAGFLSRLFFWWFTKMAIYGYRHPLEEK 238
Query: 247 AIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPN----------------------RTPS 284
+ L R+ L +A+ +Q+K+ A H R PS
Sbjct: 239 DLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPS 298
Query: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
A+ FG L+S+ F+ + DLL F P +S +++ IS ++
Sbjct: 299 FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRF-------------ISNPMAP 345
Query: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
+ +++A L+FL ++Q LQ Y+ TG+ R ++ +IY K L ++ S
Sbjct: 346 SWW---GFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKR 402
Query: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
T+G+I NL++++ + M LW+ P+QII+ + L+ LG S L G A +V
Sbjct: 403 AS--TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMV 460
Query: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
LL P+ +A K+ Q + R+K +EIL GIK+LKLYAWE F K VE R
Sbjct: 461 LLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQG 520
Query: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLAT 554
EL L+T A + + F P L T
Sbjct: 521 ELQLLRTAAYLHTTTTFTWMCSPFLVRLGT 550
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,758,405
Number of Sequences: 37866
Number of extensions: 2138270
Number of successful extensions: 18699
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 202
Number of HSP's successfully gapped in prelim test: 82
Number of HSP's that attempted gapping in prelim test: 14269
Number of HSP's gapped (non-prelim): 2502
length of query: 1513
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1398
effective length of database: 13,892,928
effective search space: 19422313344
effective search space used: 19422313344
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.