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Search of human proteins with 110832835
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110832835 ATP-binding cassette, sub-family C, member 9
isoform SUR2A [Homo sapiens]
(1549 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 3068 0.0
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 3018 0.0
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 2978 0.0
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 2084 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 758 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 748 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 717 0.0
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 672 0.0
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 668 0.0
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 661 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 654 0.0
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 633 0.0
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 600 e-171
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 597 e-170
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 567 e-161
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 551 e-156
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 551 e-156
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 500 e-141
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 495 e-139
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 446 e-125
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 355 2e-97
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 285 3e-76
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 224 4e-58
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 214 7e-55
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 207 8e-53
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 199 2e-50
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 190 1e-47
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 161 5e-39
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 159 3e-38
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 150 1e-35
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 3068 bits (7955), Expect = 0.0
Identities = 1549/1549 (100%), Positives = 1549/1549 (100%)
Query: 1 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH 60
MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH
Sbjct: 1 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH 60
Query: 61 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV 120
NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV
Sbjct: 61 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV 120
Query: 121 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL 180
YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL
Sbjct: 121 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL 180
Query: 181 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK 240
MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK
Sbjct: 181 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK 240
Query: 241 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS 300
KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS
Sbjct: 241 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS 300
Query: 301 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL 360
STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL
Sbjct: 301 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL 360
Query: 361 ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE 420
ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE
Sbjct: 361 ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE 420
Query: 421 TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA 480
TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA
Sbjct: 421 TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA 480
Query: 481 QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI 540
QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI
Sbjct: 481 QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI 540
Query: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII 600
FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII
Sbjct: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII 600
Query: 601 SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTR 660
SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTR
Sbjct: 601 SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTR 660
Query: 661 RLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG 720
RLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG
Sbjct: 661 RLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG 720
Query: 721 EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR 780
EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR
Sbjct: 721 EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR 780
Query: 781 YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS 840
YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS
Sbjct: 781 YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS 840
Query: 841 ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 900
ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ
Sbjct: 841 ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 900
Query: 901 TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960
TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE
Sbjct: 901 TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960
Query: 961 EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS 1020
EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS
Sbjct: 961 EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS 1020
Query: 1021 EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP 1080
EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP
Sbjct: 1021 EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP 1080
Query: 1081 IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL 1140
IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL
Sbjct: 1081 IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL 1140
Query: 1141 PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE 1200
PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE
Sbjct: 1141 PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE 1200
Query: 1201 LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN 1260
LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN
Sbjct: 1201 LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN 1260
Query: 1261 YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR 1320
YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR
Sbjct: 1261 YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR 1320
Query: 1321 YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL 1380
YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL
Sbjct: 1321 YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL 1380
Query: 1381 PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA 1440
PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA
Sbjct: 1381 PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA 1440
Query: 1441 VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV 1500
VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV
Sbjct: 1441 VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV 1500
Query: 1501 VTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK 1549
VTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK
Sbjct: 1501 VTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK 1549
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 3018 bits (7824), Expect = 0.0
Identities = 1523/1545 (98%), Positives = 1533/1545 (99%)
Query: 1 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH 60
MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH
Sbjct: 1 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH 60
Query: 61 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV 120
NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV
Sbjct: 61 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV 120
Query: 121 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL 180
YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL
Sbjct: 121 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL 180
Query: 181 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK 240
MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK
Sbjct: 181 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK 240
Query: 241 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS 300
KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS
Sbjct: 241 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS 300
Query: 301 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL 360
STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL
Sbjct: 301 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL 360
Query: 361 ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE 420
ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE
Sbjct: 361 ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE 420
Query: 421 TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA 480
TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA
Sbjct: 421 TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA 480
Query: 481 QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI 540
QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI
Sbjct: 481 QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI 540
Query: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII 600
FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII
Sbjct: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII 600
Query: 601 SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTR 660
SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTR
Sbjct: 601 SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTR 660
Query: 661 RLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG 720
RLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG
Sbjct: 661 RLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG 720
Query: 721 EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR 780
EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR
Sbjct: 721 EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR 780
Query: 781 YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS 840
YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS
Sbjct: 781 YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS 840
Query: 841 ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 900
ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ
Sbjct: 841 ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 900
Query: 901 TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960
TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE
Sbjct: 901 TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960
Query: 961 EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS 1020
EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS
Sbjct: 961 EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS 1020
Query: 1021 EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP 1080
EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP
Sbjct: 1021 EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP 1080
Query: 1081 IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL 1140
IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL
Sbjct: 1081 IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL 1140
Query: 1141 PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE 1200
PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE
Sbjct: 1141 PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE 1200
Query: 1201 LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN 1260
LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN
Sbjct: 1201 LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN 1260
Query: 1261 YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR 1320
YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR
Sbjct: 1261 YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR 1320
Query: 1321 YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL 1380
YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL
Sbjct: 1321 YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL 1380
Query: 1381 PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA 1440
PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA
Sbjct: 1381 PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA 1440
Query: 1441 VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV 1500
VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV
Sbjct: 1441 VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV 1500
Query: 1501 VTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
VTIAHRV +I+ A LV+V G ++E DT +LLA +NG+F++ V
Sbjct: 1501 VTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFV 1545
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 2978 bits (7720), Expect = 0.0
Identities = 1513/1549 (97%), Positives = 1513/1549 (97%), Gaps = 36/1549 (2%)
Query: 1 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH 60
MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH
Sbjct: 1 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH 60
Query: 61 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV 120
NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV
Sbjct: 61 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV 120
Query: 121 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL 180
YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL
Sbjct: 121 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL 180
Query: 181 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK 240
MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK
Sbjct: 181 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK 240
Query: 241 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS 300
KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS
Sbjct: 241 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS 300
Query: 301 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL 360
STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL
Sbjct: 301 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL 360
Query: 361 ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE 420
ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE
Sbjct: 361 ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE 420
Query: 421 TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA 480
TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA
Sbjct: 421 TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA 480
Query: 481 QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI 540
QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI
Sbjct: 481 QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI 540
Query: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII 600
FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII
Sbjct: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII 600
Query: 601 SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTR 660
SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGV
Sbjct: 601 SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGV----------------------- 637
Query: 661 RLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG 720
VTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG
Sbjct: 638 -------------VTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG 684
Query: 721 EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR 780
EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR
Sbjct: 685 EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR 744
Query: 781 YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS 840
YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS
Sbjct: 745 YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS 804
Query: 841 ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 900
ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ
Sbjct: 805 ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 864
Query: 901 TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960
TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE
Sbjct: 865 TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 924
Query: 961 EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS 1020
EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS
Sbjct: 925 EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS 984
Query: 1021 EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP 1080
EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP
Sbjct: 985 EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP 1044
Query: 1081 IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL 1140
IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL
Sbjct: 1045 IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL 1104
Query: 1141 PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE 1200
PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE
Sbjct: 1105 PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE 1164
Query: 1201 LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN 1260
LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN
Sbjct: 1165 LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN 1224
Query: 1261 YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR 1320
YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR
Sbjct: 1225 YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR 1284
Query: 1321 YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL 1380
YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL
Sbjct: 1285 YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL 1344
Query: 1381 PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA 1440
PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA
Sbjct: 1345 PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA 1404
Query: 1441 VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV 1500
VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV
Sbjct: 1405 VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV 1464
Query: 1501 VTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK 1549
VTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK
Sbjct: 1465 VTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK 1513
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 2084 bits (5400), Expect = 0.0
Identities = 1061/1582 (67%), Positives = 1268/1582 (80%), Gaps = 34/1582 (2%)
Query: 1 MSLSFCG--NNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQI 58
M L+FCG N+ ++Y ++ GVL N CFVDALN+VPHVFLLFITFPILFIGWGSQSSKV I
Sbjct: 1 MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHI 60
Query: 59 HHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTS 118
HH+TWLHFPGHNLRWILTF LLFV VCEIAEGI+SD ES HLHL+MPA M F+A TS
Sbjct: 61 HHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESHHLHLYMPAGMAFMAAVTS 120
Query: 119 IVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNG 178
+VYYHNIETSNFPKLL+AL +YW +AFITKTIK VK+ + S LRFC+TG++VIL G
Sbjct: 121 VVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLVILYG 180
Query: 179 LLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISA 238
+L+ VE+NVIRVRRY+FF P++VKPPEDLQDLGVRFLQPFVNLLSK TYWWMN I +A
Sbjct: 181 MLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTA 240
Query: 239 HKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPIL 298
HKKPIDL+AIGKLPIAMRA+TNY L +A++ Q +K +IW A+ AFGR ++
Sbjct: 241 HKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLV 300
Query: 299 LSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISET--LSSKEFLENAYVLAV 356
LSSTFR LADLLGFAGPLCI GIV + + + T +SS+EFL NAYVLAV
Sbjct: 301 LSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAV 360
Query: 357 LLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNL 416
LLFLAL+LQRTFLQASYYV IETGINLRGA+ IYNKI+ LSTSNLSMGEMT GQI NL
Sbjct: 361 LLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNL 420
Query: 417 VAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATK 476
VAI+TNQLMWF FLCPNLWAMPVQII+GVILLY +LG SAL+GAAVI+LLAP+QYF+ATK
Sbjct: 421 VAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATK 480
Query: 477 LAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYT 536
L++AQ+STL+YS ERLK+TNE+L+GIKLLKLYAWE+IF VE TR KE++SL+ FA+YT
Sbjct: 481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYT 540
Query: 537 SLSIFMNAAIPIAAVLATFVTH-AYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFA 595
S+SIFMN AIPIAAVL TFV H ++ + P+ AFASLSLFHILVTPLFLLS+VVR
Sbjct: 541 SISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRST 600
Query: 596 VKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSY 655
VKA++SVQKL+EFL S EI ++ E + P K+ V + +NRK+P R
Sbjct: 601 VKALVSVQKLSEFLSSAEIREEQCAPHEPT-PQGPASKYQAVPLRVVNRKRPAREDCRGL 659
Query: 656 EQSTRRLRPA---ETEDIAIKVTNGYFSW-GSGLATLSNIDIRIPTGQLTMIVGQVGCGK 711
+ L P+ + ++ +++ GYF+W G+ TLSNI IRIP GQLTMIVGQVGCGK
Sbjct: 660 TGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGK 719
Query: 712 SSLLLAILGEMQTLEGKVHWSNVNESE----PSFEATRS-----RNRYSVAYAAQKPWLL 762
SSLLLA LGEMQ + G V WS++ +SE PS E + R R VAYA+QKPWLL
Sbjct: 720 SSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLL 779
Query: 763 NATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICV 822
NATVEENI F SPFNKQRYK V +ACSLQPDID+LP GDQT+IGERGINLSGGQRQRI V
Sbjct: 780 NATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISV 839
Query: 823 ARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWI 882
ARALYQ+ N+VFLDDPFSALDIHLSDHLMQ GIL+ L+DDKRT+VLVTHKLQYL HADWI
Sbjct: 840 ARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWI 899
Query: 883 IAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLE-RKTLRRAM 941
IAMKDG++ REGTLKD Q + +L+EHWKTLMNRQDQELEK+ ++ E + L RAM
Sbjct: 900 IAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAM 959
Query: 942 YSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSK 1001
SR+ Q E+E+EEE E +EDDN+S+++ R ++PW+ C +YL+S G LL L++FS+
Sbjct: 960 SSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQ 1019
Query: 1002 LLKHSVIVAIDYWLATWTS----------EYSINNTGKADQTYYVAGFSILCGAGIFLCL 1051
LLKH V+VAIDYWLA WT S++ DQT Y F++LC GI LCL
Sbjct: 1020 LLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCL 1079
Query: 1052 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1111
VTS+TVEW GL AK LH +LLN+IIL P+RFF+TTPLG ILNRFS+D N IDQHIP TL
Sbjct: 1080 VTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTL 1139
Query: 1112 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1171
E L+RSTLLC+SA+ +ISY TPVFLVALLPL + YFIQKYFRVAS+DLQ+LDD+TQLPL
Sbjct: 1140 ECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPL 1199
Query: 1172 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1231
L HF+ET EGLTTIRAFR+E RF+Q++LE TD+NNIA LFL+AANRWLEVR +Y+GAC+V
Sbjct: 1200 LSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVV 1259
Query: 1232 LTASIASISGS----SNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLT 1287
L A++ SIS S ++GLVGLGL YAL ++NYLNW+VRNLAD+E+Q+GAVK+++ L
Sbjct: 1260 LIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLK 1319
Query: 1288 MESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGR 1347
E+E+YEG + PS +P++WP +G+I+I +L VRY+++LKPVLKHV A I PGQK+GICGR
Sbjct: 1320 TEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGR 1379
Query: 1348 TGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNL 1407
TGSGKSS SLAFFRMVD F+G I+IDGIDI+KLPLHTLRSRLSIILQDP+LFSG+IRFNL
Sbjct: 1380 TGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNL 1439
Query: 1408 DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKS 1467
DPE KC+D LWEALEIAQLK +VK+LPGGLDA++TEGGENFS GQRQLFCLARAFVRK+
Sbjct: 1440 DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKT 1499
Query: 1468 SILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVEC 1527
SI IMDEATASIDMATENILQKVVMTAFADRTVVTIAHRV +I+ A LV+V G ++E
Sbjct: 1500 SIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEF 1559
Query: 1528 DTVPNLLAHKNGLFSTLVMTNK 1549
D LL+ K+ +F++ V +K
Sbjct: 1560 DKPEKLLSRKDSVFASFVRADK 1581
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 758 bits (1957), Expect = 0.0
Identities = 470/1396 (33%), Positives = 745/1396 (53%), Gaps = 157/1396 (11%)
Query: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
Query: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
Query: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
Query: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
Query: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRP 664
L FL +E+ DS ++ + + K G +
Sbjct: 616 LRIFLSHEELEPDS------------------IERRPV--KDGGGTN------------- 642
Query: 665 AETEDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQ 723
+I V N F+W S TL+ I IP G L +VGQVGCGKSSLL A+L EM
Sbjct: 643 ------SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMD 696
Query: 724 TLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKA 783
+EG V SVAY Q+ W+ N ++ ENI FG + Y++
Sbjct: 697 KVEGHVAIKG-----------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRS 739
Query: 784 VTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALD 843
V AC+L PD+++LP GD+TEIGE+G+NLSGGQ+QR+ +ARA+Y N +I DDP SA+D
Sbjct: 740 VIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVD 799
Query: 844 IHLSDHLMQ-----EGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKD 898
H+ H+ + +G+LK +T +LVTH + YL D II M G + G+ ++
Sbjct: 800 AHVGKHIFENVIGPKGMLK-----NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQE 854
Query: 899 IQTKDVELYEHWKTLMN-RQDQELEKD---------MEADQTT------------LERKT 936
+ +D E +T + Q+Q+ E++ EA Q L+R+
Sbjct: 855 LLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQL 914
Query: 937 LRRAMYSREAKAQMEDEDEEEEEEEDEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFL 993
+ YS + E ++ E +++ M ++ W Y+ + G F+
Sbjct: 915 SSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFI 974
Query: 994 LILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT 1053
L IF + H +A +YWL+ WT + +N T Q + S+ GI +
Sbjct: 975 SFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGT----QEHTKVRLSVYGALGISQGIAV 1030
Query: 1054 ---SLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPT 1110
S+ V G+ A++ LH +LL+ I+ P+ FF+ TP G ++NRFS + + +D IP
Sbjct: 1031 FGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEV 1090
Query: 1111 LESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLP 1170
++ S + A +I ATP+ + + PLG+ ++F+Q+++ +S+ L+ L+ ++ P
Sbjct: 1091 IKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSP 1150
Query: 1171 LLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACI 1230
+ HF+ET G++ IRAF + RF + D N AY ANRWL VR + +G CI
Sbjct: 1151 VYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCI 1210
Query: 1231 VLTASIASISG--SSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTM 1288
VL A++ ++ S ++GLVGL + Y+L +T YLNW+VR +++E + AV+++ +
Sbjct: 1211 VLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET 1270
Query: 1289 ESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRT 1348
E E + + P WPQ G ++ + C+RY +L VL+H+ I G+KVGI GRT
Sbjct: 1271 EKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1329
Query: 1349 GSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD 1408
G+GKSSL+L FR+ + +G+I+IDGI+I+K+ LH LR +++II QDP+LFSGS+R NLD
Sbjct: 1330 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1389
Query: 1409 PECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSS 1468
P + +D+ +W +LE+A LK+ V +LP LD EGGEN SVGQRQL CLARA +RK+
Sbjct: 1390 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1449
Query: 1469 ILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECD 1528
IL++DEATA++D+ T++++Q + T F D TV+TIAHR+++IMD V+V +G + E
Sbjct: 1450 ILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG 1509
Query: 1529 TVPNLLAHKNGLFSTL 1544
P+ L + GLF ++
Sbjct: 1510 -APSDLLQQRGLFYSM 1524
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 748 bits (1932), Expect = 0.0
Identities = 503/1548 (32%), Positives = 787/1548 (50%), Gaps = 186/1548 (12%)
Query: 71 LRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGF-VATTTSIVYYHNIE-TS 128
L W +++A LF + G R + P V+G + T ++ Y ++
Sbjct: 79 LLWCVSWADLFYSFHGLVHG------RAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQ 132
Query: 129 NFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCI--TGMMVILNGLLMAVEIN 186
+ L++ FL V A + K++ G RF ++L+ L++A
Sbjct: 133 SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILAC--- 189
Query: 187 VIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLK 246
R F + + V P + + LS+ +WW + I ++ P++ K
Sbjct: 190 ---FREKPPFFSAKNVDPNP--------YPETSAGFLSRLFFWWFTKMAIYGYRHPLEEK 238
Query: 247 AIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPN----------------------RTPS 284
+ L R+ L +A+ +Q+K+ A H R PS
Sbjct: 239 DLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPS 298
Query: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
A+ FG L+S+ F+ + DLL F P +S +++ IS ++
Sbjct: 299 FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRF-------------ISNPMAP 345
Query: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
+ +++A L+FL ++Q LQ Y+ TG+ R ++ +IY K L ++ S
Sbjct: 346 SWW---GFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKR 402
Query: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
T+G+I NL++++ + M LW+ P+QII+ + L+ LG S L G A +V
Sbjct: 403 AS--TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMV 460
Query: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
LL P+ +A K+ Q + R+K +EIL GIK+LKLYAWE F K VE R
Sbjct: 461 LLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQG 520
Query: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVT 583
EL L+T A + + F P L T + Y NN+ AE AF S+SLF+IL
Sbjct: 521 ELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRL 580
Query: 584 PLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTIN 643
PL +L ++ +A +S++++ +FL +E+ S V+ KTI+
Sbjct: 581 PLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQS------------------VERKTIS 622
Query: 644 RKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLA-TLSNIDIRIPTGQLTM 702
PG AI + +G F+W L TL ++DI++P G L
Sbjct: 623 ---PG---------------------YAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVA 658
Query: 703 IVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLL 762
+VG VGCGKSSL+ A+LGEM+ LEGKVH SVAY Q+ W+
Sbjct: 659 VVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-----------------SVAYVPQQAWIQ 701
Query: 763 NATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICV 822
N T++EN+ FG N +RY+ +AC+L D+++LP GDQTEIGE+GINLSGGQRQR+ +
Sbjct: 702 NCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSL 761
Query: 823 ARALYQNTNIVFLDDPFSALDIHLSDHLMQ-----EGILKFLQDDKRTLVLVTHKLQYLT 877
ARA+Y + +I LDDP SA+D H++ H+ EG+L +T VLVTH + +L
Sbjct: 762 ARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLA-----GKTRVLVTHGISFLP 816
Query: 878 HADWIIAMKDGSVLREGTLKDIQTKDVE----------------LYEHWKTLMNRQDQE- 920
D+II + DG V G + ++ L + W L +D+E
Sbjct: 817 QTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEA 876
Query: 921 -LEKDMEADQTTLERKT----LRRAMYSREAKAQMEDED--------------EEEEEEE 961
L +D ++ T L + + + R+ A D + E+ + E
Sbjct: 877 LLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTE 936
Query: 962 DEDDNMSTVMRLRT--KMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWT 1019
+ D T + W Y + G + + + + + + + WL+ WT
Sbjct: 937 AKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWT 996
Query: 1020 SEYSI----NNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNK 1075
++ NNT Y A IL G FL ++ ++ + G+ AA+ LH LL+
Sbjct: 997 NDAMADSRQNNTSLRLGVY--AALGILQG---FLVMLAAMAMAAGGIQAARVLHQALLHN 1051
Query: 1076 IILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVF 1135
I P FFDTTP G ILN FS D ++D+ + P + L S +S + +I +TP+F
Sbjct: 1052 KIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLF 1111
Query: 1136 LVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFK 1195
V +LPL V + +Q+++ S+ L+ L+ ++ P+ HFSET G + IRA+ F+
Sbjct: 1112 TVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFE 1171
Query: 1196 QRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSS--NSGLVGLGLL 1253
D N + +NRWL + +++G C+VL A++ ++ G S N GLVGL +
Sbjct: 1172 IISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVS 1231
Query: 1254 YALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIK 1313
Y+L +T LNW++R ++DLE + AV++V + E+E ++ S+ PE WP GE++
Sbjct: 1232 YSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEA-PWVVEGSRPPEGWPPRGEVE 1290
Query: 1314 IHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVID 1373
+ VRY L VL+ + ++ G+KVGI GRTG+GKSS++L FR+++ G+I ID
Sbjct: 1291 FRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRID 1350
Query: 1374 GIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKS 1433
G++++ + LH LRS+L+II QDPILFSG++R NLDP +++ +W ALE++ L V S
Sbjct: 1351 GLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSS 1410
Query: 1434 LPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMT 1493
P GLD +EGGEN SVGQRQL CLARA +RKS IL++DEATA+ID+ T+N++Q + T
Sbjct: 1411 QPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRT 1470
Query: 1494 AFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLF 1541
F TV+TIAHR+++IMD VLV +G++ E D+ NL+A + G+F
Sbjct: 1471 QFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAAR-GIF 1517
Score = 99.4 bits (246), Expect = 2e-20
Identities = 119/477 (24%), Positives = 200/477 (41%), Gaps = 53/477 (11%)
Query: 1089 LGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAI-------GMISYATPVFLVALLP 1141
+G I+N S D + P L L + L + AI G A F+V L+P
Sbjct: 406 VGEIVNLMSVDAQRF-MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIP 464
Query: 1142 LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQ----- 1196
L A + F+V L++ +++ L+ SE G+ ++ + E F +
Sbjct: 465 LNGAVAVKMRAFQVKQMKLKD----SRIKLM---SEILNGIKVLKLYAWEPSFLKQVEGI 517
Query: 1197 RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLL 1253
R EL AYL + W+ + +L I L + + + V + L
Sbjct: 518 RQGELQLLRTAAYLHTTTTFTWM--CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLF 575
Query: 1254 YALTIT-NYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG-E 1311
L + N L ++ NL V + K++ FL+ E +DP V G
Sbjct: 576 NILRLPLNMLPQLISNLTQASVSL---KRIQQFLSQEE------LDPQSVERKTISPGYA 626
Query: 1312 IKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIV 1371
I IH + +L P L + + G V + G G GKSSL A ++ +GK+
Sbjct: 627 ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH 686
Query: 1372 IDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMV 1431
+ G ++ +P + LQ+ +LF + L+P+ R + LE L +
Sbjct: 687 MKG-SVAYVPQQAWIQNCT--LQENVLFGKA----LNPK------RYQQTLEACALLADL 733
Query: 1432 KSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKV 1490
+ LPGG + E G N S GQRQ LARA + I ++D+ +++D ++I V
Sbjct: 734 EMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHV 793
Query: 1491 V--MTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
+ A +T V + H +S + ++V ++G + E P LL +NG F+ +
Sbjct: 794 IGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALL-QRNGSFANFL 849
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 717 bits (1851), Expect = 0.0
Identities = 462/1503 (30%), Positives = 752/1503 (50%), Gaps = 217/1503 (14%)
Query: 137 LFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLLMAVEINVIRVRRYVFF 196
L L+W+++ + T + ++ L N + + I G + + I F
Sbjct: 132 LSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILIFS------AFS 185
Query: 197 MNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMR 256
N + P + + LS TY W +++I+ +K+P+ L+ + ++ M+
Sbjct: 186 ENNESSNNPSSI-----------ASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMK 234
Query: 257 AVT-----------------------------------------------NYVCLKDAYE 269
T + + L+D
Sbjct: 235 TKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDV-- 292
Query: 270 EQKKKVADHPNRTPSIWL--AMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNE 327
E+KKK + P WL A+++ F +L S + + D+ F P + ++ ++
Sbjct: 293 EKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASD 352
Query: 328 TQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGAL 387
+L Y+ A+LLF A ++Q LQ + + + G+ +R A+
Sbjct: 353 RDT----------------YLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAI 396
Query: 388 LAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVIL 447
+A +Y K L LS NL+ E T+G+ NL++++ +LM LW+ +QI++ +
Sbjct: 397 MASVYKKALTLS--NLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFF 454
Query: 448 LYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKL 507
L+ LG S L G V+VL+ PI ++TK Q + +RLK NEIL GIK+LK
Sbjct: 455 LWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKY 514
Query: 508 YAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLK 567
+AWE F V+ R KEL +L F+ + IF+ P+ + TF + NN+
Sbjct: 515 FAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNIL 574
Query: 568 PAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSL 626
A+ AF S++LF+IL PL +L ++ ++A +S ++L ++L D++
Sbjct: 575 DAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDL------------ 622
Query: 627 PFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWG-SGL 685
T +R D A++ + F+W
Sbjct: 623 -------------------------------DTSAIRHDCNFDKAMQFSEASFTWEHDSE 651
Query: 686 ATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATR 745
AT+ ++++ I GQL ++G VG GKSSL+ A+LGEM+ + G +
Sbjct: 652 ATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKG------------ 699
Query: 746 SRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEI 805
+ AY Q+ W+ N T+++NI FG+ FN++RY+ V +AC+L PD+++LP GD EI
Sbjct: 700 -----TTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEI 754
Query: 806 GERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE-----GILKFLQ 860
GE+GINLSGGQ+QRI +ARA YQN +I LDDP SA+D H+ H+ + G+LK
Sbjct: 755 GEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLK--- 811
Query: 861 DDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQE 920
+T +LVTH + +L D I+ + +G+++ +G+ + K E ++ KT + E
Sbjct: 812 --GKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPE 869
Query: 921 LEKDM----------------------EADQTTLER-------------------KTLRR 939
E + +A T+ R K+LR
Sbjct: 870 EEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRN 929
Query: 940 AMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIF 999
++ +R + EDE+ + ++ + + + T K+ + YL + G F + +I
Sbjct: 930 SLKTRNVNSLKEDEELVKGQKLIKKEFIET-----GKVKFSIYLEYLQAIGLFSIFFIIL 984
Query: 1000 SKLLKHSVIVAIDYWLATWTSEYSINNT-----GKADQTYYVAGFSILCGAGIFLCLVTS 1054
+ ++ + + WL+ WTS+ I N+ + D V G ++ GIF+ +
Sbjct: 985 AFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYG-ALGLAQGIFVFIAHF 1043
Query: 1055 LTVEWMGLTAAKN-LHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLES 1113
+ G A N LH LLN I+ P+RFFDTTP G I+NRF+ D + +D +P +L S
Sbjct: 1044 WSA--FGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRS 1101
Query: 1114 LTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLC 1173
L +S + MI ATPVF + ++PLG+ + +Q ++ S+ L+ LD T+ P+
Sbjct: 1102 WITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYS 1161
Query: 1174 HFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLT 1233
HFSET GL IRAF H+ RF + DTN +NRWL +R + +G V
Sbjct: 1162 HFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFF 1221
Query: 1234 ASIASI--SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE 1291
+++ + + + VG L AL IT LNW+VR +++E + AV+++ + +E+E
Sbjct: 1222 SALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENE 1281
Query: 1292 NYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSG 1351
+ + P WP +G+I+ ++ VRY L VL+ + I +K+G+ GRTG+G
Sbjct: 1282 --APWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAG 1339
Query: 1352 KSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPEC 1411
KSSL+ FR+++ G+I+IDG+DI+ + LH LR +L+II QDPILFSGS+R NLDP
Sbjct: 1340 KSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFN 1399
Query: 1412 KCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILI 1471
+D+ +W+ALE+A LK+ V SL GL VTE G N S+GQRQL CL RA +RKS IL+
Sbjct: 1400 NYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILV 1459
Query: 1472 MDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVP 1531
+DEATA++D+ T+N++Q + FA TV+TIAHR+ +IMD+ V+V G ++EC +
Sbjct: 1460 LDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPE 1519
Query: 1532 NLL 1534
LL
Sbjct: 1520 ELL 1522
Score = 75.9 bits (185), Expect = 3e-13
Identities = 140/671 (20%), Positives = 274/671 (40%), Gaps = 68/671 (10%)
Query: 895 TLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREA------KA 948
TL+D+ D E+ KTL+++ + ++++++ + L+R+ + + + A K
Sbjct: 222 TLEDVWEVDEEMKT--KTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKN 279
Query: 949 QMEDED----EEEEEEEDEDDNMSTVMRL-RTKMPWKTCWRYLTSGGFFLLILMIFS--- 1000
Q + +D E+ E+++ + V + K +KT + L L+ IF+
Sbjct: 280 QSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVS 339
Query: 1001 -KLLKHSVIVAIDYWLATWTSEYS--INNTGKADQTYYVAGFSILC---GAGIFLCLVTS 1054
+LLK + A D W + T Q++ + + LC G + ++ S
Sbjct: 340 PQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMAS 399
Query: 1055 LTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESL 1114
+ + + L+ NL K +G +N S D + + + L
Sbjct: 400 VYKKALTLS-------NLARK----------EYTVGETVNLMSVDAQKL-MDVTNFMHML 441
Query: 1115 TRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCH 1174
S L + +I + ++A + + V I SK +Q + + L
Sbjct: 442 WSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKI 501
Query: 1175 FSETAEGLTTIRAFRHETRFKQRMLELTDT---NNIAYLFLSAANRWLEVRTDYLGACIV 1231
+E G+ ++ F E F+ ++ L N +A+ L ++ T L + +
Sbjct: 502 MNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVT 561
Query: 1232 LTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE 1291
+ + SN+ L ++T+ N L + L+ L + + ++ + S T E
Sbjct: 562 FSVYVLV---DSNNILDAQKAFTSITLFNILRFP---LSMLPMMISSMLQA-SVSTERLE 614
Query: 1292 NYEG--TMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1349
Y G +D S + + ++ + +E++ + ++ V I GQ V + G G
Sbjct: 615 KYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVG 674
Query: 1350 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1409
SGKSSL A ++ G I I G + + Q + +G+I+ N+
Sbjct: 675 SGKSSLISAMLGEMENVHGHITIKGTT-------------AYVPQQSWIQNGTIKDNILF 721
Query: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469
+ + R + LE L ++ LPGG A + E G N S GQ+Q LARA + I
Sbjct: 722 GTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDI 781
Query: 1470 LIMDEATASIDM-ATENILQKVV--MTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVE 1526
++D+ +++D ++I KV+ +T + + H + + ++V G +VE
Sbjct: 782 YLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVE 841
Query: 1527 CDTVPNLLAHK 1537
+ LLA K
Sbjct: 842 KGSYSALLAKK 852
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 672 bits (1734), Expect = 0.0
Identities = 425/1303 (32%), Positives = 677/1303 (51%), Gaps = 156/1303 (11%)
Query: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
Query: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
Query: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
Query: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
Query: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRP 664
L FL +E+ DS ++ + + K G +
Sbjct: 616 LRIFLSHEELEPDS------------------IERRPV--KDGGGTN------------- 642
Query: 665 AETEDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQ 723
+I V N F+W S TL+ I IP G L +VGQVGCGKSSLL A+L EM
Sbjct: 643 ------SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMD 696
Query: 724 TLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKA 783
+EG V SVAY Q+ W+ N ++ ENI FG + Y++
Sbjct: 697 KVEGHVAIKG-----------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRS 739
Query: 784 VTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALD 843
V AC+L PD+++LP GD+TEIGE+G+NLSGGQ+QR+ +ARA+Y N +I DDP SA+D
Sbjct: 740 VIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVD 799
Query: 844 IHLSDHLMQ-----EGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKD 898
H+ H+ + +G+LK +T +LVTH + YL D II M G + G+ ++
Sbjct: 800 AHVGKHIFENVIGPKGMLK-----NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQE 854
Query: 899 IQTKDVELYEHWKTLMN-RQDQELEKD---------MEADQTT------------LERKT 936
+ +D E +T + Q+Q+ E++ EA Q L+R+
Sbjct: 855 LLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQL 914
Query: 937 LRRAMYSREAKAQMEDEDEEEEEEEDEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFL 993
+ YS + E ++ E +++ M ++ W Y+ + G F+
Sbjct: 915 SSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFI 974
Query: 994 LILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT 1053
L IF + H +A +YWL+ WT + +N T Q + S+ GI +
Sbjct: 975 SFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGT----QEHTKVRLSVYGALGISQGIAV 1030
Query: 1054 ---SLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPT 1110
S+ V G+ A++ LH +LL+ I+ P+ FF+ TP G ++NRFS + + +D IP
Sbjct: 1031 FGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEV 1090
Query: 1111 LESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLP 1170
++ S + A +I ATP+ + + PLG+ ++F+Q+++ +S+ L+ L+ ++ P
Sbjct: 1091 IKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSP 1150
Query: 1171 LLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACI 1230
+ HF+ET G++ IRAF + RF + D N AY ANRWL VR + +G CI
Sbjct: 1151 VYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCI 1210
Query: 1231 VLTASIASISG--SSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTM 1288
VL A++ ++ S ++GLVGL + Y+L +T YLNW+VR +++E + AV+++ +
Sbjct: 1211 VLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET 1270
Query: 1289 ESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRT 1348
E E + + P WPQ G ++ + C+RY +L VL+H+ I G+KVGI GRT
Sbjct: 1271 EKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1329
Query: 1349 GSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD 1408
G+GKSSL+L FR+ + +G+I+IDGI+I+K+ LH LR +++II QDP+LFSGS+R NLD
Sbjct: 1330 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1389
Query: 1409 PECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSV 1451
P + +D+ +W +LE+A LK+ V +LP LD EGGEN V
Sbjct: 1390 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
Score = 85.1 bits (209), Expect = 5e-16
Identities = 139/651 (21%), Positives = 259/651 (39%), Gaps = 88/651 (13%)
Query: 934 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 989
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
Query: 990 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1045
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
Query: 1046 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1099
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 1100 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1152
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
Query: 1153 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1207
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
Query: 1208 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1263
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1319
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
Query: 1320 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISK 1379
+ + P L + I G V + G+ G GKSSL A +D +G + I G
Sbjct: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG----- 706
Query: 1380 LPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLD 1439
++ + Q + + S+R N+ C+ + ++ L ++ LP G
Sbjct: 707 --------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDR 758
Query: 1440 AVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKVV--MTAFA 1496
+ E G N S GQ+Q LARA + I + D+ +++D ++I + V+
Sbjct: 759 TEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK 818
Query: 1497 DRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMT 1547
++T + + H +S + +++V S G + E + LLA ++G F+ + T
Sbjct: 819 NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA-RDGAFAEFLRT 868
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 668 bits (1723), Expect = 0.0
Identities = 439/1391 (31%), Positives = 701/1391 (50%), Gaps = 203/1391 (14%)
Query: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
Query: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
Query: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
Query: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
Query: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRP 664
L FL +E+ DS ++ + + K G +
Sbjct: 616 LRIFLSHEELEPDS------------------IERRPV--KDGGGTN------------- 642
Query: 665 AETEDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQ 723
+I V N F+W S TL+ I IP G L +VGQVGCGKSSLL A+L EM
Sbjct: 643 ------SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMD 696
Query: 724 TLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKA 783
+EG V SVAY Q+ W+ N ++ ENI FG + Y++
Sbjct: 697 KVEGHVAIKG-----------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRS 739
Query: 784 VTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALD 843
V AC+L PD+++ L G R I
Sbjct: 740 VIQACALLPDLEI---------------LPSGDRTEI----------------------- 761
Query: 844 IHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD 903
++T +LVTH + YL D II M G + G+ +++ +D
Sbjct: 762 ------------------GEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARD 803
Query: 904 VELYEHWKTLMN-RQDQELEKD---------MEADQTT------------LERKTLRRAM 941
E +T + Q+Q+ E++ EA Q L+R+ +
Sbjct: 804 GAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSS 863
Query: 942 YSREAKAQMEDEDEEEEEEEDEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMI 998
YS + E ++ E +++ M ++ W Y+ + G F+ L I
Sbjct: 864 YSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSI 923
Query: 999 FSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT---SL 1055
F + H +A +YWL+ WT + +N T Q + S+ GI + S+
Sbjct: 924 FLFMCNHVSALASNYWLSLWTDDPIVNGT----QEHTKVRLSVYGALGISQGIAVFGYSM 979
Query: 1056 TVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLT 1115
V G+ A++ LH +LL+ I+ P+ FF+ TP G ++NRFS + + +D IP ++
Sbjct: 980 AVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFM 1039
Query: 1116 RSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHF 1175
S + A +I ATP+ + + PLG+ ++F+Q+++ +S+ L+ L+ ++ P+ HF
Sbjct: 1040 GSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHF 1099
Query: 1176 SETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTAS 1235
+ET G++ IRAF + RF + D N AY ANRWL VR + +G CIVL A+
Sbjct: 1100 NETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAA 1159
Query: 1236 IASISG--SSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENY 1293
+ ++ S ++GLVGL + Y+L +T YLNW+VR +++E + AV+++ + E E
Sbjct: 1160 LFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA- 1218
Query: 1294 EGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKS 1353
+ + P WPQ G ++ + C+RY +L VL+H+ I G+KVGI GRTG+GKS
Sbjct: 1219 PWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKS 1278
Query: 1354 SLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKC 1413
SL+L FR+ + +G+I+IDGI+I+K+ LH LR +++II QDP+LFSGS+R NLDP +
Sbjct: 1279 SLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQY 1338
Query: 1414 TDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMD 1473
+D+ +W +LE+A LK+ V +LP LD EGGEN SVGQRQL CLARA +RK+ IL++D
Sbjct: 1339 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1398
Query: 1474 EATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNL 1533
EATA++D+ T++++Q + T F D TV+TIAHR+++IMD V+V +G + E P+
Sbjct: 1399 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG-APSD 1457
Query: 1534 LAHKNGLFSTL 1544
L + GLF ++
Sbjct: 1458 LLQQRGLFYSM 1468
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 661 bits (1705), Expect = 0.0
Identities = 432/1377 (31%), Positives = 715/1377 (51%), Gaps = 117/1377 (8%)
Query: 222 LLSKATYWWMNTLIISAHKK-PIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVA-DHP 279
L S T+ W+++L AHKK + ++ + L + N L+ ++E+ +V D
Sbjct: 106 LFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAA 165
Query: 280 NRTPSIWLAMYRAFGRP-ILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGI 338
+ +W+ F R ++LS + L GF+GP + +V+ + E T +
Sbjct: 166 SLRRVVWI-----FCRTRLILSIVCLMITQLAGFSGP---AFMVKHLLEYTQATESN--- 214
Query: 339 SETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRL 398
L+ + +L + L L I++ L ++ + TG+ LRGA+L M + KIL+L
Sbjct: 215 ---------LQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKL 265
Query: 399 STSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALV 458
++ E +LG++ N+ + + ++ + L PV I+G+I +LG + +
Sbjct: 266 K----NIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFL 321
Query: 459 GAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSV 518
G+AV +L P F + A ++ + + ER++K NE+L IK +K+YAW F +SV
Sbjct: 322 GSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSV 381
Query: 519 EETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLF 578
++ R +E L+ + S+++ + + + A + TF H G +L A+AF +++F
Sbjct: 382 QKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHM-TLGFDLTAAQAFTVVTVF 440
Query: 579 HILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEI------------------GDDSWR 620
+ + L + V+ +A ++V + L +E+ +W
Sbjct: 441 NSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWD 500
Query: 621 TGESSLPF-------------------ESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRR 661
+ SS+ E ++ + + + +Q G LDS E
Sbjct: 501 SSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDE----- 555
Query: 662 LRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGE 721
RP+ E+ + G+ TL +ID+ I G+L I G VG GK+SL+ AILG+
Sbjct: 556 -RPSPEEEEGKHIHLGHLRLQR---TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQ 611
Query: 722 MQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRY 781
M LEG + S + AY AQ+ W+LNAT+ +NI FG ++++RY
Sbjct: 612 MTLLEGSIAISG-----------------TFAYVAQQAWILNATLRDNILFGKEYDEERY 654
Query: 782 KAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSA 841
+V ++C L+PD+ +LP D TEIGERG NLSGGQRQRI +ARALY + +I LDDP SA
Sbjct: 655 NSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSA 714
Query: 842 LDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQT 901
LD H+ +H+ I K L+ +T++ VTH+LQYL D +I MK+G + GT +++
Sbjct: 715 LDAHVGNHIFNSAIRKHLKS--KTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMN 772
Query: 902 KDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEE 961
+ + + L+ + +E + + + + ++K+ + + K + + EE + +
Sbjct: 773 LNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQ 832
Query: 962 DEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAID-YWLATWTS 1020
E+ +V PW Y+ + G L L+I + + + A +WL+ W
Sbjct: 833 LEEKGQGSV-------PWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIK 885
Query: 1021 EYSINNT-GKADQT-------------YYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK 1066
+ S N T + ++T YY + +++ + L + + L A+
Sbjct: 886 QGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASS 945
Query: 1067 NLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIG 1126
LH L +I+ P++FFDTTP G ILNRFS D + +D +P E ++ +L +G
Sbjct: 946 RLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVG 1005
Query: 1127 MISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIR 1186
MI+ P FLVA+ PL + F + RV ++L+ LD+ TQ P L H + + +GL TI
Sbjct: 1006 MIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIH 1065
Query: 1187 AFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTAS--IASISGSSN 1244
A+ F R EL D N + + A RWL VR D + ++ T I + G
Sbjct: 1066 AYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIP 1125
Query: 1245 SGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPE 1304
GL + YA+ +T + VR ++ E + +V+++N ++ S +
Sbjct: 1126 PAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSP 1185
Query: 1305 HWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVD 1364
WPQEGE+ + +RY NL VLK V IKP +K+GI GRTGSGKSSL +A FR+V+
Sbjct: 1186 DWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVE 1245
Query: 1365 IFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEI 1424
+ G I IDG+ IS + L LRS+LSII Q+P+LFSG++R NLDP + T+D++W+ALE
Sbjct: 1246 LSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALER 1305
Query: 1425 AQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE 1484
+K + LP L++ V E G+NFSVG+RQL C+ARA +R ILI+DEATA++D T+
Sbjct: 1306 THMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETD 1365
Query: 1485 NILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLF 1541
++Q+ + AFAD T++TIAHR+ +++ + ++V ++G +VE DT LL++ + F
Sbjct: 1366 LLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 654 bits (1688), Expect = 0.0
Identities = 437/1367 (31%), Positives = 710/1367 (51%), Gaps = 120/1367 (8%)
Query: 200 QKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVT 259
Q+VKP LQD NL S+ +WW+N L HK+ ++ + + R+
Sbjct: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
Query: 260 NYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCIS 319
L+ ++++ + A++ + PS+ A+ + + + L+ F + + P+ +
Sbjct: 56 LGEELQGFWDKEVLR-AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
Query: 320 GIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLA-VLLFLALILQRTFLQASYYVTIE 378
I+ N N + L AY A VL F LIL L Y+ ++
Sbjct: 115 KII-------NYFENYDPMDSVA-----LNTAYAYATVLTFCTLIL--AILHHLYFYHVQ 160
Query: 379 -TGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
G+ LR A+ MIY K LRLS N++MG+ T GQI NL++ + N+ LWA
Sbjct: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
Query: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
P+Q I LL+ +G S L G AV+++L P+Q + + T ++ R++ NE
Sbjct: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
Query: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
++ GI+++K+YAWE F + R KE+S + + +++ + V TF T
Sbjct: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
Query: 558 HAYASGNNLKPAEAFASLSLFHI--LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIG 615
+ G+ + + F +++L+ L LF S + R + +AI+S++++ FLL DEI
Sbjct: 339 YVLL-GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVS-EAIVSIRRIQTFLLLDEIS 396
Query: 616 DDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVT 675
Q R+L + + ++
Sbjct: 397 -----------------------------------------QRNRQLPSDGKKMVHVQDF 415
Query: 676 NGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 735
++ S TL + + G+L +VG VG GKSSLL A+LGE+ G V
Sbjct: 416 TAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV------ 469
Query: 736 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDID 795
+ R +AY +Q+PW+ + T+ NI FG + K+RY+ V AC+L+ D+
Sbjct: 470 -------SVHGR----IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQ 518
Query: 796 LLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGI 855
LL GD T IG+RG LSGGQ+ R+ +ARA+YQ+ +I LDDP SA+D +S HL + I
Sbjct: 519 LLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCI 578
Query: 856 LKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN 915
+ L + + +LVTH+LQYL A I+ +KDG ++++GT + ++ + +L+
Sbjct: 579 CQILHE--KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGID----FGSLLK 632
Query: 916 RQDQELEKDMEADQTTLERKTLRRAMY--SREAKAQMEDEDEEEEEEEDEDDNMSTVMRL 973
+ ++E E+ TL +T + + ++ ++D E ++ E+ +S R
Sbjct: 633 KDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRS 692
Query: 974 RTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAI---DYWLATWTSEYSINN---- 1026
K+ ++ Y +G + I+ IF LL + VA D+WL+ W ++ S+ N
Sbjct: 693 EGKVGFQAYKNYFRAGAHW--IVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVN 750
Query: 1027 -----TGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPI 1081
T K D +Y+ +S L A + + SL V ++ + +++ LH+ + I+ P+
Sbjct: 751 GGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPV 810
Query: 1082 RFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLP 1141
FFD P+G ILNRFS D +D +P T ++ L + + + P + L+P
Sbjct: 811 LFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVP 870
Query: 1142 LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLEL 1201
LG+ F F+++YF S+D++ L+ +T+ P+ H S + +GL TIRA++ E R ++
Sbjct: 871 LGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAH 930
Query: 1202 TDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASI--SGSSNSGLVGLGLLYALTIT 1259
D ++ A+ +RW VR D + A V+ + S+ + + ++G VGL L YALT+
Sbjct: 931 QDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLM 990
Query: 1260 NYLNWVVRNLADLEVQMGAVKKVNSFLTMESEN-YEGTMDPSQVPEHWPQEGEIKIHDLC 1318
W VR A++E M +V++V + +E E +E P P WP EG I ++
Sbjct: 991 GMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRP---PPAWPHEGVIIFDNVN 1047
Query: 1319 VRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDIS 1378
Y VLKH+ A IK +KVGI GRTG+GKSSL A FR+ + +GKI ID I +
Sbjct: 1048 FMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTT 1106
Query: 1379 KLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGL 1438
++ LH LR ++SII Q+P+LF+G++R NLDP + TD+ LW AL+ QLK ++ LPG +
Sbjct: 1107 EIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKM 1166
Query: 1439 DAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADR 1498
D + E G NFSVGQRQL CLARA +RK+ ILI+DEATA++D T+ ++QK + FA
Sbjct: 1167 DTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHC 1226
Query: 1499 TVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
TV+TIAHR+++I+D+ ++V G L E D LL +K LF +V
Sbjct: 1227 TVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 633 bits (1632), Expect = 0.0
Identities = 413/1314 (31%), Positives = 668/1314 (50%), Gaps = 138/1314 (10%)
Query: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
+W A+Y AFGR L + + +LGF+GPL +S +V + E Q E LS
Sbjct: 230 LWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQ----------EPLSH 279
Query: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
L A LA L +LQ + Y VT++ RGA+L ++Y K L+L S
Sbjct: 280 G--LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQA----RGAVLNILYCKALQLGPSRPP 333
Query: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
GE NL+ ++ +L+ F W +P+Q+ + + LLY +G + + G + +
Sbjct: 334 TGEAL-----NLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILAL 388
Query: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
LL P+ IAT++ + + L + R+K E+L GI+++K WE VE R +
Sbjct: 389 LLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRAR 448
Query: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTP 584
EL L+ + +++ AA+P+ + F+T+ G+ L + F +L+L +L+ P
Sbjct: 449 ELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLM-GHQLTATKVFTALALVRMLILP 507
Query: 585 LFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINR 644
L V+ ++A +S+ ++ FL ++ + + G Q K +
Sbjct: 508 LNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCG--------RLGAQIKWLLC 559
Query: 645 KQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSW---GSGLAT-LSNIDIRIPTGQL 700
P PAE + +++ FSW G+ L T +S+++++ G L
Sbjct: 560 SDP----------------PAEPSTV-LELHGALFSWDPVGTSLETFISHLEVK--KGML 600
Query: 701 TMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPW 760
IVG+VGCGKSSLL AI GE+ L G V A R ++ A Q+PW
Sbjct: 601 VGIVGKVGCGKSSLLAAIAGELHRLRGHV-------------AVRGLSK-GFGLATQEPW 646
Query: 761 LLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRI 820
+ AT+ +NI FG F+ Q YK V +AC+L D+ +LP GDQTE+GE+G+ LSGGQR RI
Sbjct: 647 IQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARI 706
Query: 821 CVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHAD 880
+ARA+YQ + LDDP +A+D +++HL+ IL L R +L TH+ +YL AD
Sbjct: 707 ALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTR--LLCTHRTEYLERAD 764
Query: 881 WIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRA 940
++ M+ G ++R G +I + + W E E+D T +
Sbjct: 765 AVLLMEAGRLIRAGPPSEILPLVQAVPKAWA----------ENGQESDSATAQS-----V 809
Query: 941 MYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFS 1000
+ K +E+E E+ + L ++ W+ + G L + ++FS
Sbjct: 810 QNPEKTKEGLEEEQSTSGRLLQEESKKEGAVALHV---YQAYWKAVGQG---LALAILFS 863
Query: 1001 KLLKHSVIVAIDYWLATWTSEYSINNT--------------------------------- 1027
LL + A D+WL+ W S+ N+
Sbjct: 864 LLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVF 923
Query: 1028 --------GKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILG 1079
G +D +Y+ ++ + G L+ ++ L AA LH LL+++++
Sbjct: 924 PLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMA 983
Query: 1080 PIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVAL 1139
P+ FF+ TP G ILNRFS+D D +P L L + L + ++ P L+ L
Sbjct: 984 PVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLL 1043
Query: 1140 LPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML 1199
PL + +Y +Q+++R +S++L+ L T PL H ++T GL+ +RA RF++ L
Sbjct: 1044 PPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENL 1103
Query: 1200 ELTDTNNIAYLFLSAANRWLEVRTDYLGACIV-LTASIASI---SGSSNSGLVGLGLLYA 1255
L + N SA +WL++R +GA +V A IA + G +N GLVGL L YA
Sbjct: 1104 RLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYA 1163
Query: 1256 LTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIH 1315
L++T L+ +V + E + +V+++ + + +G P Q+ W +G ++
Sbjct: 1164 LSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG--QPLQLGTGWLTQGGVEFQ 1221
Query: 1316 DLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGI 1375
D+ + Y L L V ++PG+K+GI GRTGSGKSSL L FR+++ G++++DG+
Sbjct: 1222 DVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGV 1281
Query: 1376 DISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLP 1435
D S+L L LRS+L+II Q+P LFSG++R NLDP+ D LW+AL+ L ++ S+
Sbjct: 1282 DTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM- 1340
Query: 1436 GGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAF 1495
GGLD + EGG + S+GQRQL CLARA + + IL +DEATAS+D T+ +LQ+ + F
Sbjct: 1341 GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRF 1400
Query: 1496 ADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK 1549
A++TV+TIAHR+++I+++ VLV G +VE D+ L + LF L+ +++
Sbjct: 1401 ANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQ 1454
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 600 bits (1546), Expect = e-171
Identities = 460/1527 (30%), Positives = 730/1527 (47%), Gaps = 146/1527 (9%)
Query: 67 PGHNLRWILTFALLFVHVCEIAEGI--VSDSRRESRHLHLFMPAVMGFVATTTSIVYYHN 124
P + +L FAL+ + +A + + E+ L P V ++ T + V+ +
Sbjct: 67 PLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEF-LIHPTV--WLTTMSFAVFLIH 123
Query: 125 IETSNFPKLLLALFLYWVMAFITKTIKLVKYCQ-SGLDISNLRFCITGMMVILNGLLMAV 183
E + LF YW++ F+ + +G +R T + + L ++
Sbjct: 124 TERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSL--VVAQF 181
Query: 184 EINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPI 243
++ + + F +PQ+ P + G F SKAT+WW++ L+ +++P+
Sbjct: 182 VLSCLADQPPFFPEDPQQSNP---CPETGAAFP-------SKATFWWVSGLVWRGYRRPL 231
Query: 244 ---DLKAIGKL----PIAMRAVTNYVCLKDAYEEQKKKVA---------DHPNRTP---- 283
DL ++G+ + R ++ + A K +A P P
Sbjct: 232 RPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQ 291
Query: 284 --SIWL----AMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTG 337
S W A+++ F LL + ++D+ F P +S ++ + +
Sbjct: 292 EGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDP--------- 342
Query: 338 ISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILR 397
K Y+LAVL+FL+ LQ F Q + Y + LR A+ ++Y K+L
Sbjct: 343 -------KPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLA 395
Query: 398 LSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSAL 457
LS+ S +G + NLV+++ +L + LW V I++ + L+ LLG SAL
Sbjct: 396 LSSG--SRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSAL 453
Query: 458 VGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKS 517
AV + L P+ +FI+ K Q+ + R + T+ IL+ K +K + WE F
Sbjct: 454 TAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDR 513
Query: 518 VEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSL 577
V R +EL +L+T L S+S+ L F H + N + +AF +L++
Sbjct: 514 VLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTV 573
Query: 578 FHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGV 637
+IL L + V+A +S +L FL +E V
Sbjct: 574 LNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEE-----------------------V 610
Query: 638 QPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGS-GLATLSNIDIRIP 696
P ++ G A +D I + + F+W L I++ +P
Sbjct: 611 DPGVVDSSSSGS---------------AAGKD-CITIHSATFAWSQESPPCLHRINLTVP 654
Query: 697 TGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAA 756
G L +VG VG GKSSLL A+LGE+ +EG V S E +VAY
Sbjct: 655 QGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV----------SIEG-------AVAYVP 697
Query: 757 QKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQ 816
Q+ W+ N +V EN+ FG + + V +AC+LQPD+D P G T IGE+G+NLSGGQ
Sbjct: 698 QEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQ 757
Query: 817 RQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYL 876
+QR+ +ARA+Y+ + LDDP +ALD H+ H+ + I T +LVTH L L
Sbjct: 758 KQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHIL 817
Query: 877 THADWIIAMKDGSVLREGTLKDIQTKD---VELYEHWKTLMNRQDQELEKDMEADQ---T 930
ADWII + +G++ G+ +++ + V L + + +R + E E T
Sbjct: 818 PQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGT 877
Query: 931 TLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD--------NMSTVMRLRTKMPWKTC 982
+ R+ R S ++ + + E + E DD ++ R K
Sbjct: 878 SAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLA 937
Query: 983 WRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSIL 1042
YL + G L + +F L + YWL+ W + ++ G+ Q G L
Sbjct: 938 --YLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVG--GQQTQAALRGGIFGL 993
Query: 1043 CGAGIFLCLVTSLTVEWMG-LTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTN 1101
G + L S+ +G A++ L LL ++ PI FF+ TP+G +LNRFS +T+
Sbjct: 994 LGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD 1053
Query: 1102 IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQ 1161
+D IP L SL L +++ ATP+ VA+LPL + + Q + V+S L+
Sbjct: 1054 TVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLR 1113
Query: 1162 ELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF-KQRMLELTDTNNIAYLFLSAANRWLE 1220
L+ ++ + H +ET +G T +RAFR + F Q + ++ I++ L A+RWL
Sbjct: 1114 RLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRL-VADRWLA 1172
Query: 1221 VRTDYLGACIVLTASIASISGSSN--SGLVGLGLLYALTITNYLNWVVRNLADLEVQMGA 1278
+ LG +V A+ ++ ++ +GLVG + AL +T L WVVRN DLE + +
Sbjct: 1173 ANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVS 1232
Query: 1279 VKKVNSFL-TMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIK 1337
V+++ + T + + +Q P WPQ G+I+ D +RY L ++ V I
Sbjct: 1233 VERMQDYAWTPKEAPWRLPTCAAQPP--WPQGGQIEFRDFGLRYRPELPLAVQGVSFKIH 1290
Query: 1338 PGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPI 1397
G+KVGI GRTG+GKSSL+ R+ + +G I IDG+ I+ + LHTLRSR+SII QDPI
Sbjct: 1291 AGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPI 1350
Query: 1398 LFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLF 1457
LF GS+R NLD + +D+ +W ALE QLK +V SLPG L + GE+ SVGQ+QL
Sbjct: 1351 LFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLL 1410
Query: 1458 CLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVL 1517
CLARA +RK+ ILI+DEATA++D TE +Q ++ + FA TV+ IAHR+ S+MD VL
Sbjct: 1411 CLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVL 1470
Query: 1518 VFSEGILVECDTVPNLLAHKNGLFSTL 1544
V +G + E + LLA K GLF L
Sbjct: 1471 VMDKGQVAESGSPAQLLAQK-GLFYRL 1496
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 597 bits (1539), Expect = e-170
Identities = 432/1367 (31%), Positives = 671/1367 (49%), Gaps = 128/1367 (9%)
Query: 224 SKATYWWMNTLIISAHKKPI---DLKAIGKL----PIAMRAVTNYVCLKDAYEEQKKKVA 276
SKAT+WW++ L+ +++P+ DL ++G+ + R ++ + A K +A
Sbjct: 21 SKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIA 80
Query: 277 ---------DHPNRTP------SIWL----AMYRAFGRPILLSSTFRYLADLLGFAGPLC 317
P P S W A+++ F LL + ++D+ F P
Sbjct: 81 FKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKL 140
Query: 318 ISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTI 377
+S ++ + + K Y+LAVL+FL+ LQ F Q + Y
Sbjct: 141 LSLFLEFIGDP----------------KPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLK 184
Query: 378 ETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
+ LR A+ ++Y K+L LS+ S +G + NLV+++ +L + LW
Sbjct: 185 VLQMRLRSAITGLVYRKVLALSSG--SRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLP 242
Query: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
V I++ + L+ LLG SAL AV + L P+ +FI+ K Q+ + R + T+
Sbjct: 243 LVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSS 302
Query: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
IL+ K +K + WE F V R +EL +L+T L S+S+ L F
Sbjct: 303 ILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAV 362
Query: 558 HAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDD 617
H + N + +AF +L++ +IL L + V+A +S +L FL +E
Sbjct: 363 HTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEE---- 418
Query: 618 SWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNG 677
V P ++ G A +D I + +
Sbjct: 419 -------------------VDPGAVDSSSSGS---------------AAGKD-CITIQSA 443
Query: 678 YFSWGS-GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNE 736
F+W L I++ +P G L +VG VG GKSSLL A+LGE+ +EG V
Sbjct: 444 TFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV------- 496
Query: 737 SEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDL 796
S E +VAY Q+ W+ N +V EN+ FG + + V +AC+LQPD+D
Sbjct: 497 ---SIEG-------AVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDS 546
Query: 797 LPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGIL 856
P G T IGE+G+NLSGGQ+QR+ +ARA+Y+ + LDDP +ALD H+ H+ + I
Sbjct: 547 FPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIG 606
Query: 857 KFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHWKTL 913
T +LVTH L L ADWII + +G++ G+ +++ + V L + +
Sbjct: 607 PGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQP 666
Query: 914 MNRQDQELEKDMEADQ---TTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----- 965
+R + E E T+ R+ R S ++ + + E + E DD
Sbjct: 667 GDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAG 726
Query: 966 ---NMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEY 1022
++ R K YL + G L + +F L + YWL+ W +
Sbjct: 727 WPAGKDSIQYGRVKATVHLA--YLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDP 784
Query: 1023 SINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMG-LTAAKNLHHNLLNKIILGPI 1081
++ G+ Q G L G + L S+ +G A++ L LL ++ PI
Sbjct: 785 AVG--GQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPI 842
Query: 1082 RFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLP 1141
FF+ TP+G +LNRFS +T+ +D IP L SL L +++ ATP+ VA+LP
Sbjct: 843 SFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILP 902
Query: 1142 LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF-KQRMLE 1200
L + + Q + V+S L+ L+ ++ + H +ET +G T +RAFR + F Q
Sbjct: 903 LFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNAR 962
Query: 1201 LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSN--SGLVGLGLLYALTI 1258
+ ++ I++ L A+RWL + LG +V A+ ++ ++ +GLVG + AL +
Sbjct: 963 VDESQRISFPRL-VADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQV 1021
Query: 1259 TNYLNWVVRNLADLEVQMGAVKKVNSFL-TMESENYEGTMDPSQVPEHWPQEGEIKIHDL 1317
T L WVVRN DLE + +V+++ + T + + +Q P WPQ G+I+ D
Sbjct: 1022 TQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPP--WPQGGQIEFQDF 1079
Query: 1318 CVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDI 1377
+RY L ++ V I G+KVGI GRTG+GKSSL+ R+ + +G I IDG+ I
Sbjct: 1080 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1139
Query: 1378 SKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGG 1437
+ + LHTLRSR+SII QDPILF GS+R NLD + +D+ +W ALE QLK +V SLPG
Sbjct: 1140 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQ 1199
Query: 1438 LDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFAD 1497
L + GE+ SVGQ+QL CLARA +RK+ ILI+DEATA++D TE +Q ++ + FA
Sbjct: 1200 LQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQ 1259
Query: 1498 RTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1544
TV+ IAHR+ S+MD VLV +G + E + LLA K GLF L
Sbjct: 1260 CTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK-GLFYRL 1305
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 567 bits (1461), Expect = e-161
Identities = 394/1370 (28%), Positives = 680/1370 (49%), Gaps = 130/1370 (9%)
Query: 222 LLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNR 281
LLS AT+ W+ +++ +++ + + + L + TN + ++E+ +V P +
Sbjct: 51 LLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVG--PEK 108
Query: 282 TPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGP-LCISGIVQRVNETQNGTNNTTGISE 340
S+ +++ +L+ L ++ GP + I I+Q+ T G+
Sbjct: 109 A-SLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCI 167
Query: 341 TLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLST 400
L + EF + + F AL ++ + T I L+ AL +++ ++ T
Sbjct: 168 ALFATEFTK-------VFFWAL---------AWAINYRTAIRLKVALSTLVFENLVSFKT 211
Query: 401 SNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGA 460
+ +++G++ N+++ ++ L CP +P+ ++ + +LG +AL+G
Sbjct: 212 ----LTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGI 267
Query: 461 AVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEE 520
+V V+ P+Q F+A + ++S + + +R++ NE L I+L+K+YAWE F ++++
Sbjct: 268 SVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQD 327
Query: 521 TRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHI 580
R +E L+ S + + + A++ T H P AF+ +++F++
Sbjct: 328 IRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPV-AFSVIAMFNV 386
Query: 581 LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSD---------EIGDDSWRTGESSLPFESC 631
+ + +L ++ +A +S++++ + L+ E D ++L +E
Sbjct: 387 MKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWE-- 444
Query: 632 KKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNI 691
H + T + Q + HL ++S +E A T S + L +I
Sbjct: 445 --HEASRKSTPKKLQNQKRHLCKKQRSEAY---SERSPPAKGATGPEEQSDSLKSVLHSI 499
Query: 692 DIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYS 751
+ G++ I G VG GKSSLL A+LG+MQ +G V + +
Sbjct: 500 SFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG-----------------T 542
Query: 752 VAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGIN 811
+AY +Q+ W+ + V ENI FG ++ QRY+ C LQ D+ LP+GD TEIGERG+N
Sbjct: 543 LAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLN 602
Query: 812 LSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTH 871
LSGGQRQRI +ARA+Y + + LDDP SA+D H+ H+ +E I K L+ +T+VLVTH
Sbjct: 603 LSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRG--KTVVLVTH 660
Query: 872 KLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTT 931
+LQ+L D +I ++DG + +GT K++ E + K + N + + KD E
Sbjct: 661 QLQFLESCDEVILLEDGEICEKGTHKELME---ERGRYAKLIHNLRGLQF-KDPEHLYNA 716
Query: 932 LERKTLRRAMYSREAKAQM------EDEDEEEEEE---EDEDDNMSTVMRLRTKMP---- 978
+ + + RE A + ++DE +E E E D + ++T+ P
Sbjct: 717 AMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGT 776
Query: 979 --WKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYY 1035
WKT Y+ SGG+ L + +F LL ++WL W + S G
Sbjct: 777 VTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQ----- 831
Query: 1036 VAGFSILCGAGIFLCLVTSLTVEWM----------------------GLTAAKNLHHNLL 1073
G +C G L + +W+ L A+ +LH +
Sbjct: 832 --GNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVF 889
Query: 1074 NKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATP 1133
+KI+ P+ FFDTTP G ++NRFS D + +D +P E+ + + + + +++ P
Sbjct: 890 DKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFP 949
Query: 1134 VFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETR 1193
L+ + L V F+ + + F ++L+++++ ++ P H + + +GL I A+ +
Sbjct: 950 AVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKK-- 1007
Query: 1194 FKQRMLELTDTNNIAYLFLSAANRWLEVRTDYL------GACIVLTASIASISGSSNSGL 1247
E T ++ L+ + A RW +R D L +++T S +SIS SS
Sbjct: 1008 ------ESCITYHL--LYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSK--- 1056
Query: 1248 VGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWP 1307
GL L Y + ++ L VR + + + +V+ + +++ + P+ WP
Sbjct: 1057 -GLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWP 1115
Query: 1308 QEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFD 1367
GEI D +RY +N VL + I+ GQ VGI GRTGSGKSSL +A FR+V+
Sbjct: 1116 SRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPAS 1175
Query: 1368 GKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQL 1427
G I ID +DI L L LR++L++I QDP+LF G++R+NLDP TD+ LW+ LE +
Sbjct: 1176 GTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFM 1235
Query: 1428 KNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENIL 1487
++ + LP L A VTE GENFSVG+RQL C+ARA +R S I+++DEATAS+D T+ ++
Sbjct: 1236 RDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLV 1295
Query: 1488 QKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHK 1537
Q + AF TV+TIAHR++++++ VLV G ++E D P +LA K
Sbjct: 1296 QNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDK-PEVLAEK 1344
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 551 bits (1420), Expect = e-156
Identities = 407/1399 (29%), Positives = 665/1399 (47%), Gaps = 136/1399 (9%)
Query: 204 PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249
PP D +R + PF L S T W+ L+I + + +D I
Sbjct: 59 PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118
Query: 250 KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309
L + + N L +EE+ V+ S+ L M R ++ + +
Sbjct: 119 PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175
Query: 310 LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369
GP+ I + +E Q G N G+ L LFL+ ++
Sbjct: 176 ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220
Query: 370 QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429
+S+ + T I R A+ + + K+++ S+ +T G+ + + N L +
Sbjct: 221 SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276
Query: 430 LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489
P + +++ I Y ++G +A + +L+ P+ F+ +AQ T + S
Sbjct: 277 YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336
Query: 490 ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549
+R++ T+E+L IKL+K+Y WE F K +E+ R KE L+ L SL+ IP
Sbjct: 337 QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396
Query: 550 AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609
A + H L + AF+ L+ ++L +F + V+ + +V + +F
Sbjct: 397 ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455
Query: 610 LSDE--IGDDSWRTGESSLPFESCK-KHTGVQPKTINRKQPGRYHLDSYEQSTRRL-RPA 665
L + + + +L FE P +N G L+ ++ + RP
Sbjct: 456 LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVN----GALELERNGHASEGMTRPR 511
Query: 666 ETEDIAIKVTNGYFSWGSGLAT-LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQT 724
+ G G+ L L I++ + G + + G G GKSSLL AIL EM
Sbjct: 512 DAL--------GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563
Query: 725 LEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAV 784
LEG V S+AY Q+ W+++ + ENI G ++K RY V
Sbjct: 564 LEGSVGVQG-----------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQV 606
Query: 785 TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDI 844
CSL D++LLPFGD TEIGERG+NLSGGQ+QRI +ARA+Y + I LDDP SA+D
Sbjct: 607 LHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDA 666
Query: 845 HLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDV 904
H+ H+ +E I K L+ +T+VLVTH+LQYL II +++G + GT ++ K
Sbjct: 667 HVGKHIFEECIKKTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKG 724
Query: 905 ELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEE 956
+ + L+ + +E DM D + K + S+ +E+ E +
Sbjct: 725 K----YAQLIQKMHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQL 777
Query: 957 EEEEEDEDDNMSTVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWL 1015
+EEE E+ ++S W+ Y+ +GG+ + ++ F +L + + +WL
Sbjct: 778 TQEEEMEEGSLS----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWL 827
Query: 1016 ATWTSEYSINNTGKADQ---------------TYY--VAGFSIL-------CGAGIFLCL 1051
+ W + S N+ + ++Y V G + L C +GIF
Sbjct: 828 SYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF--- 884
Query: 1052 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1111
T +T + A+ LH+ L NK+ P+ FFDT P+G +LN F+ D +DQ +P
Sbjct: 885 -TKVTRK-----ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938
Query: 1112 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1171
E +L+ ++ + ++S +P L+ + V + F+ A + L++ ++ PL
Sbjct: 939 EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998
Query: 1172 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1231
H + +GL++I + F + LTD N L ++ RW+ +R + + +
Sbjct: 999 FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058
Query: 1232 LTASIASISGSSNS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTME 1289
L ++ G S++ + + L + + R + E Q AV+++ ++ M
Sbjct: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118
Query: 1290 SENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1349
M+ + P+ WPQ GEI D ++Y +N VL + I+ + VGI GRTG
Sbjct: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178
Query: 1350 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1409
SGKSSL +A FR+V+ G+I+IDG+DI + L LRS+LS+I QDP+L SG+IRFNLDP
Sbjct: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238
Query: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469
+ TD ++W+ALE L + P L V E G NFSVG+RQL C+ARA +R S I
Sbjct: 1239 FDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKI 1298
Query: 1470 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDT 1529
+++DEATASIDM T+ ++Q+ + AF TV+ IAHRV+++++ +LV G +VE D
Sbjct: 1299 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1358
Query: 1530 VPNLLAHKNG-LFSTLVMT 1547
P +L K G LF+ L+ T
Sbjct: 1359 -PEVLRKKPGSLFAALMAT 1376
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 551 bits (1420), Expect = e-156
Identities = 407/1399 (29%), Positives = 665/1399 (47%), Gaps = 136/1399 (9%)
Query: 204 PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249
PP D +R + PF L S T W+ L+I + + +D I
Sbjct: 59 PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118
Query: 250 KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309
L + + N L +EE+ V+ S+ L M R ++ + +
Sbjct: 119 PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175
Query: 310 LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369
GP+ I + +E Q G N G+ L LFL+ ++
Sbjct: 176 ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220
Query: 370 QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429
+S+ + T I R A+ + + K+++ S+ +T G+ + + N L +
Sbjct: 221 SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276
Query: 430 LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489
P + +++ I Y ++G +A + +L+ P+ F+ +AQ T + S
Sbjct: 277 YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336
Query: 490 ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549
+R++ T+E+L IKL+K+Y WE F K +E+ R KE L+ L SL+ IP
Sbjct: 337 QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396
Query: 550 AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609
A + H L + AF+ L+ ++L +F + V+ + +V + +F
Sbjct: 397 ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455
Query: 610 LSDE--IGDDSWRTGESSLPFESCK-KHTGVQPKTINRKQPGRYHLDSYEQSTRRL-RPA 665
L + + + +L FE P +N G L+ ++ + RP
Sbjct: 456 LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVN----GALELERNGHASEGMTRPR 511
Query: 666 ETEDIAIKVTNGYFSWGSGLAT-LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQT 724
+ G G+ L L I++ + G + + G G GKSSLL AIL EM
Sbjct: 512 DAL--------GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563
Query: 725 LEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAV 784
LEG V S+AY Q+ W+++ + ENI G ++K RY V
Sbjct: 564 LEGSVGVQG-----------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQV 606
Query: 785 TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDI 844
CSL D++LLPFGD TEIGERG+NLSGGQ+QRI +ARA+Y + I LDDP SA+D
Sbjct: 607 LHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDA 666
Query: 845 HLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDV 904
H+ H+ +E I K L+ +T+VLVTH+LQYL II +++G + GT ++ K
Sbjct: 667 HVGKHIFEECIKKTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKG 724
Query: 905 ELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEE 956
+ + L+ + +E DM D + K + S+ +E+ E +
Sbjct: 725 K----YAQLIQKMHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQL 777
Query: 957 EEEEEDEDDNMSTVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWL 1015
+EEE E+ ++S W+ Y+ +GG+ + ++ F +L + + +WL
Sbjct: 778 TQEEEMEEGSLS----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWL 827
Query: 1016 ATWTSEYSINNTGKADQ---------------TYY--VAGFSIL-------CGAGIFLCL 1051
+ W + S N+ + ++Y V G + L C +GIF
Sbjct: 828 SYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF--- 884
Query: 1052 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1111
T +T + A+ LH+ L NK+ P+ FFDT P+G +LN F+ D +DQ +P
Sbjct: 885 -TKVTRK-----ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938
Query: 1112 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1171
E +L+ ++ + ++S +P L+ + V + F+ A + L++ ++ PL
Sbjct: 939 EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998
Query: 1172 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1231
H + +GL++I + F + LTD N L ++ RW+ +R + + +
Sbjct: 999 FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058
Query: 1232 LTASIASISGSSNS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTME 1289
L ++ G S++ + + L + + R + E Q AV+++ ++ M
Sbjct: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118
Query: 1290 SENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1349
M+ + P+ WPQ GEI D ++Y +N VL + I+ + VGI GRTG
Sbjct: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178
Query: 1350 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1409
SGKSSL +A FR+V+ G+I+IDG+DI + L LRS+LS+I QDP+L SG+IRFNLDP
Sbjct: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238
Query: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469
+ TD ++W+ALE L + P L V E G NFSVG+RQL C+ARA +R S I
Sbjct: 1239 FDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKI 1298
Query: 1470 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDT 1529
+++DEATASIDM T+ ++Q+ + AF TV+ IAHRV+++++ +LV G +VE D
Sbjct: 1299 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1358
Query: 1530 VPNLLAHKNG-LFSTLVMT 1547
P +L K G LF+ L+ T
Sbjct: 1359 -PEVLRKKPGSLFAALMAT 1376
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 500 bits (1288), Expect = e-141
Identities = 392/1399 (28%), Positives = 645/1399 (46%), Gaps = 174/1399 (12%)
Query: 204 PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249
PP D +R + PF L S T W+ L+I + + +D I
Sbjct: 59 PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118
Query: 250 KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309
L + + N L +EE+ V+ S+ L M R ++ + +
Sbjct: 119 PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175
Query: 310 LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369
GP+ I + +E Q G N G+ L LFL+ ++
Sbjct: 176 ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220
Query: 370 QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429
+S+ + T I R A+ + + K+++ S+ +T G+ + + N L +
Sbjct: 221 SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276
Query: 430 LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489
P + +++ I Y ++G +A + +L+ P+ F+ +AQ T + S
Sbjct: 277 YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336
Query: 490 ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549
+R++ T+E+L IKL+K+Y WE F K +E+ R KE L+ L SL+ IP
Sbjct: 337 QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396
Query: 550 AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609
A + H L + AF+ L+ ++L +F + V+ + +V + +F
Sbjct: 397 ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455
Query: 610 LSDE--IGDDSWRTGESSLPFESCK-KHTGVQPKTINRKQPGRYHLDSYEQSTRRL-RPA 665
L + + + +L FE P +N G L+ ++ + RP
Sbjct: 456 LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVN----GALELERNGHASEGMTRPR 511
Query: 666 ETEDIAIKVTNGYFSWGSGLAT-LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQT 724
+ G G+ L L I++ + G + + G G GKSSLL AIL EM
Sbjct: 512 DAL--------GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563
Query: 725 LEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAV 784
LEG V S+AY Q+ W+++ + ENI G ++K RY V
Sbjct: 564 LEGSVGVQG-----------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQV 606
Query: 785 TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDI 844
CSL D++LLPFGD TEIGERG+NLSGGQ+QRI +ARA+Y + I LDDP SA+D
Sbjct: 607 LHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDA 666
Query: 845 HLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDV 904
H+ H+ +E I K L+ +T+VLVTH+LQYL II +++G + GT ++ K
Sbjct: 667 HVGKHIFEECIKKTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKG 724
Query: 905 ELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEE 956
+ + L+ + +E DM D + K + S+ +E+ E +
Sbjct: 725 K----YAQLIQKMHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQL 777
Query: 957 EEEEEDEDDNMSTVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWL 1015
+EEE E+ ++S W+ Y+ +GG+ + ++ F +L + + +WL
Sbjct: 778 TQEEEMEEGSLS----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWL 827
Query: 1016 ATWTSEYSINNTGKADQ---------------TYY--VAGFSIL-------CGAGIFLCL 1051
+ W + S N+ + ++Y V G + L C +GIF
Sbjct: 828 SYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF--- 884
Query: 1052 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1111
T +T + A+ LH+ L NK+ P+ FFDT P+G +LN F+ D +DQ +P
Sbjct: 885 -TKVTRK-----ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938
Query: 1112 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1171
E +L+ ++ + ++S +P L+ + V + F+ A + L++ ++ PL
Sbjct: 939 EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998
Query: 1172 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1231
H + +GL++I + F + LTD N L ++ RW+ +R + + +
Sbjct: 999 FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058
Query: 1232 LTASIASISGSSNS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTME 1289
L ++ G S++ + + L + + R + E Q AV+++ ++ M
Sbjct: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118
Query: 1290 SENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1349
M+ + P+ WPQ GEI D ++Y +N VL + I+ + VGI GRTG
Sbjct: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178
Query: 1350 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1409
SGKSSL +A FR+V+ G+I+IDG+DI + L LRS+LS+I QDP+L SG+IRFNLDP
Sbjct: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238
Query: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469
+ TD ++W+ALE R F+ K+ I
Sbjct: 1239 FDRHTDQQIWDALE-------------------------------------RTFLTKAII 1261
Query: 1470 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDT 1529
LI DEATASIDM T+ ++Q+ + AF TV+ IAHRV+++++ +LV G +VE D
Sbjct: 1262 LI-DEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320
Query: 1530 VPNLLAHKNG-LFSTLVMT 1547
P +L K G LF+ L+ T
Sbjct: 1321 -PEVLRKKPGSLFAALMAT 1338
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 495 bits (1274), Expect = e-139
Identities = 280/772 (36%), Positives = 447/772 (57%), Gaps = 46/772 (5%)
Query: 808 RGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQ-----EGILKFLQDD 862
+G+NLSGGQ+QR+ +ARA+Y N +I DDP SA+D H+ H+ + +G+LK
Sbjct: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK----- 759
Query: 863 KRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQEL 921
+T +LVTH + YL D II M G + G+ +++ +D E +T + Q+Q+
Sbjct: 760 NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDA 819
Query: 922 EKD---------MEADQTT------------LERKTLRRAMYSREAKAQMEDEDEEEEEE 960
E++ EA Q L+R+ + YS + E ++ E
Sbjct: 820 EENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAE 879
Query: 961 EDEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLAT 1017
+++ M ++ W Y+ + G F+ L IF + H +A +YWL+
Sbjct: 880 AKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSL 939
Query: 1018 WTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLN 1074
WT + +N T Q + S+ GI + S+ V G+ A++ LH +LL+
Sbjct: 940 WTDDPIVNGT----QEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLH 995
Query: 1075 KIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPV 1134
I+ P+ FF+ TP G ++NRFS + + +D IP ++ S + A +I ATP+
Sbjct: 996 SILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPI 1055
Query: 1135 FLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF 1194
+ + PLG+ ++F+Q+++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF
Sbjct: 1056 AAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERF 1115
Query: 1195 KQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGL 1252
+ D N AY ANRWL VR + +G CIVL A++ ++ S ++GLVGL +
Sbjct: 1116 IHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSV 1175
Query: 1253 LYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEI 1312
Y+L +T YLNW+VR +++E + AV+++ + E E + + P WPQ G +
Sbjct: 1176 SYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRV 1234
Query: 1313 KIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1372
+ + C+RY +L VL+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+I
Sbjct: 1235 EFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIII 1294
Query: 1373 DGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVK 1432
DGI+I+K+ LH LR +++II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V
Sbjct: 1295 DGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVS 1354
Query: 1433 SLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVM 1492
+LP LD EGGEN SVGQRQL CLARA +RK+ IL++DEATA++D+ T++++Q +
Sbjct: 1355 ALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIR 1414
Query: 1493 TAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1544
T F D TV+TIAHR+++IMD V+V +G + E P+ L + GLF ++
Sbjct: 1415 TQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG-APSDLLQQRGLFYSM 1465
Score = 222 bits (565), Expect = 2e-57
Identities = 166/556 (29%), Positives = 259/556 (46%), Gaps = 98/556 (17%)
Query: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
Query: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
Query: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
Query: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
Query: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRP 664
L FL H ++P +I R RP
Sbjct: 616 LRIFL-----------------------SHEELEPDSIER------------------RP 634
Query: 665 AET--EDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGE 721
+ +I V N F+W S TL+ I IP G L +VGQVGCGKSSLL A+L E
Sbjct: 635 VKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 694
Query: 722 MQTLEGKVHWSNVNES 737
M +EG V VN S
Sbjct: 695 MDKVEGHVAIKGVNLS 710
Score = 90.1 bits (222), Expect = 1e-17
Identities = 110/482 (22%), Positives = 205/482 (42%), Gaps = 73/482 (15%)
Query: 437 MPVQIIMGVILLYNLLGSSALVG-----AAVIVLLAPIQYFIATKLAEAQKSTLDYSTER 491
+P I M + L+N++G+ ++ AA+I+ + YF + A L E
Sbjct: 1028 IPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLK-RLES 1086
Query: 492 LKKT------NEILKGIKLLKLYAWEHIFCKS----VEETRMKELSSLKTFA-LYTSLSI 540
+ ++ NE L G+ +++ + + F V+E + S+ L L
Sbjct: 1087 VSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1146
Query: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKA-- 598
N + AA+ A H+ ++G LS+ + L +L + +VR + +
Sbjct: 1147 VGNCIVLFAALFAVISRHSLSAG--------LVGLSVSYSLQVTTYL-NWLVRMSSEMET 1197
Query: 599 -IISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQ 657
I++V++L E+ S+ + W+ E++ P + Q GR +Y
Sbjct: 1198 NIVAVERLKEY--SETEKEAPWQIQETAPPS--------------SWPQVGRVEFRNY-- 1239
Query: 658 STRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLA 717
LR E D ++ +I++ I G+ IVG+ G GKSSL L
Sbjct: 1240 ---CLRYREDLDFVLR----------------HINVTINGGEKVGIVGRTGAGKSSLTLG 1280
Query: 718 ILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFN 777
+ ++ EG++ +N ++ R + + Q P L + ++ N+ S ++
Sbjct: 1281 LFRINESAEGEIIIDGINIAKIGLHDLR----FKITIIPQDPVLFSGSLRMNLDPFSQYS 1336
Query: 778 KQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDD 837
+ + L+ + LP E E G NLS GQRQ +C+ARAL + T I+ LD+
Sbjct: 1337 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1396
Query: 838 PFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLK 897
+A+D+ +D L+Q I +D T++ + H+L + +I + G + G
Sbjct: 1397 ATAAVDLE-TDDLIQSTIRTQFED--CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPS 1453
Query: 898 DI 899
D+
Sbjct: 1454 DL 1455
Score = 52.0 bits (123), Expect = 4e-06
Identities = 102/479 (21%), Positives = 185/479 (38%), Gaps = 71/479 (14%)
Query: 934 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 989
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
Query: 990 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1045
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
Query: 1046 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1099
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 1100 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1152
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
Query: 1153 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1207
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
Query: 1208 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1263
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1319
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
Query: 1320 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDIS 1378
+ + P L + I G V + G+ G GKSSL A +D +G + I G+++S
Sbjct: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLS 710
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 446 bits (1148), Expect = e-125
Identities = 254/711 (35%), Positives = 408/711 (57%), Gaps = 36/711 (5%)
Query: 864 RTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQELE 922
+T +LVTH + YL D II M G + G+ +++ +D E +T + Q+Q+ E
Sbjct: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
Query: 923 KD---------MEADQTT------------LERKTLRRAMYSREAKAQMEDEDEEEEEEE 961
++ EA Q L+R+ + YS + E ++ E
Sbjct: 765 ENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 824
Query: 962 DEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 1018
+++ M ++ W Y+ + G F+ L IF + H +A +YWL+ W
Sbjct: 825 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLW 884
Query: 1019 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLNK 1075
T + +N T Q + S+ GI + S+ V G+ A++ LH +LL+
Sbjct: 885 TDDPIVNGT----QEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 940
Query: 1076 IILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVF 1135
I+ P+ FF+ TP G ++NRFS + + +D IP ++ S + A +I ATP+
Sbjct: 941 ILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIA 1000
Query: 1136 LVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFK 1195
+ + PLG+ ++F+Q+++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF
Sbjct: 1001 AIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFI 1060
Query: 1196 QRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGLL 1253
+ D N AY ANRWL VR + +G CIVL A++ ++ S ++GLVGL +
Sbjct: 1061 HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVS 1120
Query: 1254 YALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIK 1313
Y+L +T YLNW+VR +++E + AV+++ + E E + + P WPQ G ++
Sbjct: 1121 YSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVE 1179
Query: 1314 IHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVID 1373
+ C+RY +L VL+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+ID
Sbjct: 1180 FRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIID 1239
Query: 1374 GIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKS 1433
GI+I+K+ LH LR +++II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V +
Sbjct: 1240 GINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSA 1299
Query: 1434 LPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMT 1493
LP LD EGGEN SVGQRQL CLARA +RK+ IL++DEATA++D+ T++++Q + T
Sbjct: 1300 LPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRT 1359
Query: 1494 AFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1544
F D TV+TIAHR+++IMD V+V +G + E P+ L + GLF ++
Sbjct: 1360 QFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG-APSDLLQQRGLFYSM 1409
Score = 219 bits (559), Expect = 1e-56
Identities = 163/548 (29%), Positives = 256/548 (46%), Gaps = 98/548 (17%)
Query: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
Query: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
Query: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
Query: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
Query: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRP 664
L FL H ++P +I R RP
Sbjct: 616 LRIFL-----------------------SHEELEPDSIER------------------RP 634
Query: 665 AET--EDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGE 721
+ +I V N F+W S TL+ I IP G L +VGQVGCGKSSLL A+L E
Sbjct: 635 VKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 694
Query: 722 MQTLEGKV 729
M +EG V
Sbjct: 695 MDKVEGHV 702
Score = 90.1 bits (222), Expect = 1e-17
Identities = 110/482 (22%), Positives = 205/482 (42%), Gaps = 73/482 (15%)
Query: 437 MPVQIIMGVILLYNLLGSSALVG-----AAVIVLLAPIQYFIATKLAEAQKSTLDYSTER 491
+P I M + L+N++G+ ++ AA+I+ + YF + A L E
Sbjct: 972 IPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLK-RLES 1030
Query: 492 LKKT------NEILKGIKLLKLYAWEHIFCKS----VEETRMKELSSLKTFA-LYTSLSI 540
+ ++ NE L G+ +++ + + F V+E + S+ L L
Sbjct: 1031 VSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1090
Query: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKA-- 598
N + AA+ A H+ ++G LS+ + L +L + +VR + +
Sbjct: 1091 VGNCIVLFAALFAVISRHSLSAG--------LVGLSVSYSLQVTTYL-NWLVRMSSEMET 1141
Query: 599 -IISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQ 657
I++V++L E+ S+ + W+ E++ P + Q GR +Y
Sbjct: 1142 NIVAVERLKEY--SETEKEAPWQIQETAPPS--------------SWPQVGRVEFRNY-- 1183
Query: 658 STRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLA 717
LR E D ++ +I++ I G+ IVG+ G GKSSL L
Sbjct: 1184 ---CLRYREDLDFVLR----------------HINVTINGGEKVGIVGRTGAGKSSLTLG 1224
Query: 718 ILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFN 777
+ ++ EG++ +N ++ R + + Q P L + ++ N+ S ++
Sbjct: 1225 LFRINESAEGEIIIDGINIAKIGLHDLR----FKITIIPQDPVLFSGSLRMNLDPFSQYS 1280
Query: 778 KQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDD 837
+ + L+ + LP E E G NLS GQRQ +C+ARAL + T I+ LD+
Sbjct: 1281 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1340
Query: 838 PFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLK 897
+A+D+ +D L+Q I +D T++ + H+L + +I + G + G
Sbjct: 1341 ATAAVDLE-TDDLIQSTIRTQFED--CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPS 1397
Query: 898 DI 899
D+
Sbjct: 1398 DL 1399
Score = 46.2 bits (108), Expect = 2e-04
Identities = 100/473 (21%), Positives = 180/473 (38%), Gaps = 71/473 (15%)
Query: 934 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 989
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
Query: 990 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1045
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
Query: 1046 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1099
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 1100 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1152
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
Query: 1153 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1207
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
Query: 1208 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1263
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1319
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
Query: 1320 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1372
+ + P L + I G V + G+ G GKSSL A +D +G + I
Sbjct: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 355 bits (910), Expect = 2e-97
Identities = 268/943 (28%), Positives = 454/943 (48%), Gaps = 114/943 (12%)
Query: 200 QKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVT 259
Q+VKP LQD NL S+ +WW+N L HK+ ++ + + R+
Sbjct: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
Query: 260 NYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCIS 319
L+ ++++ + A++ + PS+ A+ + + + L+ F + + P+ +
Sbjct: 56 LGEELQGFWDKEVLR-AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
Query: 320 GIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLA-VLLFLALILQRTFLQASYYVTIE 378
I+ N N + L AY A VL F LIL L Y+ ++
Sbjct: 115 KII-------NYFENYDPMDSVA-----LNTAYAYATVLTFCTLIL--AILHHLYFYHVQ 160
Query: 379 -TGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
G+ LR A+ MIY K LRLS N++MG+ T GQI NL++ + N+ LWA
Sbjct: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
Query: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
P+Q I LL+ +G S L G AV+++L P+Q + + T ++ R++ NE
Sbjct: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
Query: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
++ GI+++K+YAWE F + R KE+S + + +++ + V TF T
Sbjct: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
Query: 558 HAYASGNNLKPAEAFASLSLFHI--LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIG 615
+ G+ + + F +++L+ L LF S + R + +AI+S++++ FLL DEI
Sbjct: 339 YVLL-GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVS-EAIVSIRRIQTFLLLDEIS 396
Query: 616 DDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVT 675
Q R+L + + ++
Sbjct: 397 -----------------------------------------QRNRQLPSDGKKMVHVQDF 415
Query: 676 NGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 735
++ S TL + + G+L +VG VG GKSSLL A+LGE+ G V
Sbjct: 416 TAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV------ 469
Query: 736 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDID 795
+ R +AY +Q+PW+ + T+ NI FG + K+RY+ V AC+L+ D+
Sbjct: 470 -------SVHGR----IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQ 518
Query: 796 LLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGI 855
LL GD T IG+RG LSGGQ+ R+ +ARA+YQ+ +I LDDP SA+D +S HL + I
Sbjct: 519 LLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCI 578
Query: 856 LKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN 915
+ L + + +LVTH+LQYL A I+ +KDG ++++GT + ++ + +L+
Sbjct: 579 CQILHE--KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGID----FGSLLK 632
Query: 916 RQDQELEKDMEADQTTLERKTLRRAMY--SREAKAQMEDEDEEEEEEEDEDDNMSTVMRL 973
+ ++E E+ TL +T + + ++ ++D E ++ E+ +S R
Sbjct: 633 KDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRS 692
Query: 974 RTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAI---DYWLATWTSEYSI------ 1024
K+ ++ Y +G + I+ IF LL + VA D+WL+ W ++ S+
Sbjct: 693 EGKVGFQAYKNYFRAGAHW--IVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVN 750
Query: 1025 ---NNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPI 1081
N T K D +Y+ +S L A + + SL V ++ + +++ LH+ + I+ P+
Sbjct: 751 GGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPV 810
Query: 1082 RFFDTTPLGLILNRFSADTNIIDQHIPPT-LESLTRSTLLCLS 1123
FFD P+G ILNRFS D +D +P T L+ + R L LS
Sbjct: 811 LFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQRWDLAVLS 853
Score = 87.4 bits (215), Expect = 1e-16
Identities = 103/502 (20%), Positives = 212/502 (42%), Gaps = 53/502 (10%)
Query: 1057 VEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQ-----HI--PP 1109
V+ G+ + H + K + T G I+N S D N DQ H
Sbjct: 159 VQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
Query: 1110 TLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQL 1169
L+++ + LL + IG+ A L+ LLPL F + R + + T
Sbjct: 219 PLQAIAVTALLWME-IGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM- 276
Query: 1170 PLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGAC 1229
+E G+ I+ + E F + L I+ + S+ R + + + + +
Sbjct: 277 ------NEVITGIRIIKMYAWEKSFSNLITNLRK-KEISKILRSSCLRGMNLASFFSASK 329
Query: 1230 IVLTASIAS-------ISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKV 1282
I++ + + I+ S V L LT+T + + +++ V +++++
Sbjct: 330 IIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIV---SIRRI 386
Query: 1283 NSFLTMESENYEGTMDPSQVPEHWPQEGEIKIH--DLCVRYENNLK-PVLKHVKAYIKPG 1339
+FL ++ + SQ P +G+ +H D ++ + P L+ + ++PG
Sbjct: 387 QTFLLLD--------EISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPG 438
Query: 1340 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILF 1399
+ + + G G+GKSSL A + G + + G R++ + Q P +F
Sbjct: 439 ELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWVF 485
Query: 1400 SGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCL 1459
SG++R N+ K +R + ++ LK ++ L G V+ + G S GQ+ L
Sbjct: 486 SGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNL 545
Query: 1460 ARAFVRKSSILIMDEATASIDM-ATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLV 1518
ARA + + I ++D+ +++D + ++ + + ++ + + H++ + A +L+
Sbjct: 546 ARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILI 605
Query: 1519 FSEGILVECDTVPNLLAHKNGL 1540
+G +V+ T L K+G+
Sbjct: 606 LKDGKMVQKGTYTEFL--KSGI 625
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 285 bits (728), Expect = 3e-76
Identities = 190/648 (29%), Positives = 327/648 (50%), Gaps = 45/648 (6%)
Query: 927 ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 986
A Q L + S+E ++ +E EE+ +E D+M ++ + T W T RY+
Sbjct: 797 APQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTT---WNTYLRYI 853
Query: 987 T--SGGFFLLI--LMIFSKLLKHSVIVAIDYWLATWT-------SEYSINNTGK----AD 1031
T F+LI L+IF + S++V WL T S +S NN+ +
Sbjct: 854 TVHKSLIFVLIWCLVIFLAEVAASLVVL---WLLGNTPLQDKGNSTHSRNNSYAVIITST 910
Query: 1032 QTYYVAGFSILCGAGIFLCLV---TSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTP 1088
+YYV F I G L + L + +T +K LHH +L+ ++ P+ +T
Sbjct: 911 SSYYV--FYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
Query: 1089 LGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYF 1148
G ILNRFS D I+D +P T+ + L+ + AI +++ P VA +P+ VAF
Sbjct: 969 AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
Query: 1149 IQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA 1208
++ YF S+ L++L+ + P+ H + +GL T+RAF + F+ + + +
Sbjct: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
Query: 1209 YLFLSAANRWLEVRTDYLGACIVLTASIASI-SGSSNSGLVGLGLLYALTITNYLNWVVR 1267
+ + RW ++R + + + + SI + G VG+ L A+ I + L W V
Sbjct: 1089 WFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVN 1148
Query: 1268 NLADLEVQMGAVKKVNSFLTMESENY---------EGTMDPSQVPEH--------WPQEG 1310
+ D++ M +V +V F+ M +E G + + E+ WP G
Sbjct: 1149 SSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGG 1208
Query: 1311 EIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKI 1370
++ + DL +Y +L+++ I PGQ+VG+ GRTGSGKS+L AF R+++ +G+I
Sbjct: 1209 QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEI 1267
Query: 1371 VIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNM 1430
IDG+ + L R +I Q +FSG+ R NLDP + +D +W+ + L+++
Sbjct: 1268 QIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSV 1327
Query: 1431 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 1490
++ PG LD V+ +GG S G +QL CLAR+ + K+ IL++DE +A +D T I+++
Sbjct: 1328 IEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRT 1387
Query: 1491 VMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKN 1538
+ AFAD TV+ HR+ ++++ LV E + + D++ LL ++
Sbjct: 1388 LKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
Score = 213 bits (541), Expect = 2e-54
Identities = 177/686 (25%), Positives = 324/686 (47%), Gaps = 67/686 (9%)
Query: 221 NLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYE-EQKKKVADHP 279
+++SK + W ++ +++ ++L I ++P +V + L + E E +++A
Sbjct: 10 SVVSKLFFSWTRPILRKGYRQRLELSDIYQIP----SVDSADNLSEKLEREWDRELASKK 65
Query: 280 NRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGIS 339
N P + A+ R F + F YL ++ PL + I+ +
Sbjct: 66 N--PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDP------------ 111
Query: 340 ETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLS 399
+KE A L + L L I++ L + + G+ +R A+ ++IY K L+LS
Sbjct: 112 ---DNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLS 168
Query: 400 TSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVG 459
+ L ++++GQ+ +L++ N+ L L +W P+Q+ + + L++ LL +SA G
Sbjct: 169 SRVLD--KISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCG 226
Query: 460 AAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVE 519
+++LA Q + + + + +ERL T+E+++ I+ +K Y WE K +E
Sbjct: 227 LGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIE 286
Query: 520 ETRMKELSSLK--TFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSL 577
R EL + + Y + S F + + V + + +A G L+ + F ++S
Sbjct: 287 NLRQTELKLTRKAAYVRYFNSSAFFFSGFFV--VFLSVLPYALIKGIILR--KIFTTISF 342
Query: 578 FHIL---VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKH 634
+L VT F V+ ++ ++ K+ +FL E ++T E +L
Sbjct: 343 CIVLRMAVTRQF--PWAVQTWYDSLGAINKIQDFLQKQE-----YKTLEYNLTTTEV--- 392
Query: 635 TGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIR 694
V + G L + R D ++ +N FS G L +I+ +
Sbjct: 393 --VMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSN--FSL-LGTPVLKDINFK 447
Query: 695 IPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAY 754
I GQL + G G GK+SLL+ I+GE++ EGK+ S +++
Sbjct: 448 IERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG-----------------RISF 490
Query: 755 AAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSG 814
+Q W++ T++ENI FG +++ RY++V AC L+ DI D +GE GI LSG
Sbjct: 491 CSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSG 550
Query: 815 GQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQ 874
GQR RI +ARA+Y++ ++ LD PF LD+ + + + K + + +T +LVT K++
Sbjct: 551 GQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMAN--KTRILVTSKME 608
Query: 875 YLTHADWIIAMKDGSVLREGTLKDIQ 900
+L AD I+ + +GS GT ++Q
Sbjct: 609 HLKKADKILILHEGSSYFYGTFSELQ 634
Score = 79.7 bits (195), Expect = 2e-14
Identities = 83/377 (22%), Positives = 152/377 (40%), Gaps = 47/377 (12%)
Query: 1176 SETAEGLTTIRAFRHETRFKQ-----RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACI 1230
SE E + +++A+ E ++ R EL T AY+ ++ + + +
Sbjct: 263 SEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSV 322
Query: 1231 VLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFL---- 1286
+ A I I + ++ + +T W V+ D +GA+ K+ FL
Sbjct: 323 LPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQE 379
Query: 1287 --TMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK------------------ 1326
T+E + V W +EG ++ + + NN K
Sbjct: 380 YKTLEYNLTTTEVVMENVTAFW-EEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGT 438
Query: 1327 PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLR 1386
PVLK + I+ GQ + + G TG+GK+SL + ++ +GKI G
Sbjct: 439 PVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------ 486
Query: 1387 SRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGG 1446
R+S Q + G+I+ N+ + R ++ QL+ + + V+ EGG
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 1447 ENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE-NILQKVVMTAFADRTVVTIAH 1505
S GQR LARA + + + ++D +D+ TE I + V A++T + +
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 1506 RVSSIMDAGLVLVFSEG 1522
++ + A +L+ EG
Sbjct: 606 KMEHLKKADKILILHEG 622
Score = 71.2 bits (173), Expect = 7e-12
Identities = 66/293 (22%), Positives = 129/293 (44%), Gaps = 28/293 (9%)
Query: 668 EDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEG 727
+D+ K T G G A L NI I GQ ++G+ G GKS+LL A L + T EG
Sbjct: 1213 KDLTAKYTEG------GNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EG 1265
Query: 728 KVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDA 787
++ V+ + + R + QK ++ + T +N+ ++ Q V D
Sbjct: 1266 EIQIDGVSWDSITLQQWRK----AFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADE 1321
Query: 788 CSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLS 847
L+ I+ P + + G LS G +Q +C+AR++ I+ LD+P + LD ++
Sbjct: 1322 VGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLD-PVT 1380
Query: 848 DHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELY 907
+++ + + D T++L H+++ + + +++ V + Y
Sbjct: 1381 YQIIRRTLKQAFAD--CTVILCEHRIEAMLECQQFLVIEENKVRQ--------------Y 1424
Query: 908 EHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960
+ + L+N + + +D+ L S+ A +++E EEE ++
Sbjct: 1425 DSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQD 1477
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 224 bits (572), Expect = 4e-58
Identities = 238/936 (25%), Positives = 423/936 (45%), Gaps = 86/936 (9%)
Query: 652 LDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSG--LATLSNIDIRIPTGQLTMIVGQVGC 709
+DSY +S + + ++ N +FS+ S + L +++++ +GQ +VG GC
Sbjct: 375 IDSYSKSGHKPDNIKGN---LEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGC 431
Query: 710 GKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEEN 769
GKS+ + + EG V + + R + +Q+P L T+ EN
Sbjct: 432 GKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLRE----IIGVVSQEPVLFATTIAEN 487
Query: 770 ITFG--SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALY 827
I +G + + KAV +A + I LP T +GERG LSGGQ+QRI +ARAL
Sbjct: 488 IRYGRENVTMDEIEKAVKEA-NAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALV 546
Query: 828 QNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKD 887
+N I+ LD+ SALD S+ ++Q + K + RT +++ H+L + +AD I D
Sbjct: 547 RNPKILLLDEATSALDTE-SEAVVQVALDKARKG--RTTIVIAHRLSTVRNADVIAGFDD 603
Query: 888 GSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLE-----------RKT 936
G ++ +G ++ K+ +Y T M E+E + AD++ E R +
Sbjct: 604 GVIVEKGNHDELM-KEKGIYFKLVT-MQTAGNEVELENAADESKSEIDALEMSSNDSRSS 661
Query: 937 LRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLI- 995
L R +R + + +D + +E D+++ V R T W Y G F +I
Sbjct: 662 LIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIIN 721
Query: 996 -------LMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIF 1048
+IFSK++ V ID T + + + F L
Sbjct: 722 GGLQPAFAIIFSKII--GVFTRIDD-----------PETKRQNSNLFSLLFLALGIISFI 768
Query: 1049 LCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQH 1106
+ T G K L + + ++ + +FD G + R + D +
Sbjct: 769 TFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGA 828
Query: 1107 IPPTLESLTRS-----TLLCLSAIGMISYATPVFLVALLPL-GVAFYFIQKYFR-VASKD 1159
I L +T++ T + +S I + + L+A++P+ +A K A KD
Sbjct: 829 IGSRLAVITQNIANLGTGIIISFI--YGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKD 886
Query: 1160 LQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQ---RMLELTDTNNI--AYLF-LS 1213
+EL+ S ++ +E E T+ + E +F+ + L++ N++ A++F ++
Sbjct: 887 KKELEGSGKIA-----TEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGIT 941
Query: 1214 AANRWLEVRTDYLGACIVLTASIAS--ISGSSNSGLVGLGLLYALTITNYLNWVVRNLAD 1271
+ + Y G C A + + + + LV +++ ++ + A
Sbjct: 942 FSFTQAMMYFSYAG-CFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAK 1000
Query: 1272 LEVQMG-AVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK-PVL 1329
++ + + ++S + EG M P+ + EG + ++ Y PVL
Sbjct: 1001 AKISAAHIIMIIEKTPLIDSYSTEGLM-PNTL------EGNVTFGEVVFNYPTRPDIPVL 1053
Query: 1330 KHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRL 1389
+ + +K GQ + + G +G GKS++ R D GK+++DG +I +L + LR+ L
Sbjct: 1054 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHL 1113
Query: 1390 SIILQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGG 1446
I+ Q+PILF SI N+ D + + + A + A + ++SLP V + G
Sbjct: 1114 GIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKG 1173
Query: 1447 ENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1506
S GQ+Q +ARA VR+ IL++DEAT+++D +E ++Q+ + A RT + IAHR
Sbjct: 1174 TQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHR 1233
Query: 1507 VSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFS 1542
+S+I +A L++VF G + E T LLA K FS
Sbjct: 1234 LSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFS 1269
Score = 127 bits (320), Expect = 6e-29
Identities = 77/257 (29%), Positives = 133/257 (51%), Gaps = 15/257 (5%)
Query: 1291 ENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGS 1350
+N +G ++ V +P E+KI LK + ++ GQ V + G +G
Sbjct: 386 DNIKGNLEFRNVHFSYPSRKEVKI--------------LKGLNLKVQSGQTVALVGNSGC 431
Query: 1351 GKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-P 1409
GKS+ R+ D +G + +DG DI + + LR + ++ Q+P+LF+ +I N+
Sbjct: 432 GKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYG 491
Query: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469
T D + +A++ A + + LP D +V E G S GQ+Q +ARA VR I
Sbjct: 492 RENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKI 551
Query: 1470 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDT 1529
L++DEAT+++D +E ++Q + A RT + IAHR+S++ +A ++ F +G++VE
Sbjct: 552 LLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGN 611
Query: 1530 VPNLLAHKNGLFSTLVM 1546
L+ K F + M
Sbjct: 612 HDELMKEKGIYFKLVTM 628
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 214 bits (544), Expect = 7e-55
Identities = 225/926 (24%), Positives = 411/926 (44%), Gaps = 118/926 (12%)
Query: 678 YFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 735
+FS+ S + L +++++ +GQ +VG GCGKS+ + I EG ++
Sbjct: 400 HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDG-- 457
Query: 736 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPD 793
+ +F R V +Q+P L + T+ ENI +G + + KAV +A + +
Sbjct: 458 QDIRNFNVNYLREIIGVV--SQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE-F 514
Query: 794 IDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE 853
I LP T +GERG LSGGQ+QRI +ARAL +N I+ LD+ SALD S+ +Q
Sbjct: 515 IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAEVQA 573
Query: 854 GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHW 910
+ K + RT +++ H+L + +AD I +DG ++ +G+ ++ K+ +L
Sbjct: 574 ALDKAREG--RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
Query: 911 KTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----N 966
+ Q +E E + E T + + ++ + +++ ++ + E D N
Sbjct: 632 TSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEAN 691
Query: 967 MSTVMRLRTKMPWKTCWRY--------LTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 1018
+ V L+ KT W Y + +GG +IFS+ I+AI
Sbjct: 692 VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSE------IIAI------- 738
Query: 1019 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK-------NLHHN 1071
G D +I +FL +++ T G T K L
Sbjct: 739 --------FGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSM 790
Query: 1072 LLNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMIS 1129
++ + +FD G + R + D + Q T +L + L +IS
Sbjct: 791 AFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALIAQNIANLGTGIIIS 849
Query: 1130 YA----TPVFLVALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLT 1183
+ + L+A++P+ ++ A +D +EL+ + ++ +E E +
Sbjct: 850 FIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIA-----TEAIENIR 904
Query: 1184 TIRAFRHETRFKQRMLE-----------------LTDTNNIAYLFLSAANRWLEVRTDYL 1226
T+ + E +F+ +E +T + + A+++ S A +
Sbjct: 905 TVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFR------F 958
Query: 1227 GACIVLTA-----SIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKK 1281
GA +++ + + + G V LG +A + + A L +
Sbjct: 959 GAYLIVNGHMRFRDVILVFSAIVFGAVALG--HASSFAPDYAKAKLSAAHLFMLFERQPL 1016
Query: 1282 VNSFLT--MESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPG 1339
++S+ ++ + +EG + ++V ++P + PVL+ + +K G
Sbjct: 1017 IDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV--------------PVLQGLSLEVKKG 1062
Query: 1340 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILF 1399
Q + + G +G GKS++ R D G +++DG + KL + LR++L I+ Q+PILF
Sbjct: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILF 1122
Query: 1400 SGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQL 1456
SI N+ D + D + A + A + +++LP + V + G S GQ+Q
Sbjct: 1123 DCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQR 1182
Query: 1457 FCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLV 1516
+ARA +R+ IL++DEAT+++D +E ++Q+ + A RT + IAHR+S+I +A L+
Sbjct: 1183 IAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLI 1242
Query: 1517 LVFSEGILVECDTVPNLLAHKNGLFS 1542
+VF G + E T LLA K FS
Sbjct: 1243 VVFQNGRVKEHGTHQQLLAQKGIYFS 1268
Score = 125 bits (314), Expect = 3e-28
Identities = 79/240 (32%), Positives = 134/240 (55%), Gaps = 5/240 (2%)
Query: 1309 EGEIKIHDLCVRYEN--NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIF 1366
+G ++ +D+ Y + N+K +LK + ++ GQ V + G +G GKS+ R+ D
Sbjct: 391 KGNLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD 449
Query: 1367 DGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIA 1425
+G I IDG DI ++ LR + ++ Q+P+LFS +I N+ T D + +A++ A
Sbjct: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
Query: 1426 QLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN 1485
+ LP D +V E G S GQ+Q +ARA VR IL++DEAT+++D +E
Sbjct: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
Query: 1486 ILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
+Q + A RT + IAHR+S++ +A ++ F +G++VE + L+ K G++ LV
Sbjct: 570 EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
Score = 106 bits (264), Expect = 2e-22
Identities = 71/248 (28%), Positives = 127/248 (51%), Gaps = 13/248 (5%)
Query: 652 LDSYEQSTRRLRPAETE-DIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCG 710
+DSY S L+P + E +I + + + L + + + GQ +VG GCG
Sbjct: 1017 IDSY--SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCG 1074
Query: 711 KSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENI 770
KS+++ + L G V + + + R++ + +Q+P L + ++ ENI
Sbjct: 1075 KSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQ----LGIVSQEPILFDCSIAENI 1130
Query: 771 TFGSP---FNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALY 827
+G ++ + A ++ P I+ LP +T +G++G LSGGQ+QRI +ARAL
Sbjct: 1131 AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALI 1190
Query: 828 QNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKD 887
+ I+ LD+ SALD S+ ++QE + K + RT +++ H+L + +AD I+ ++
Sbjct: 1191 RQPQILLLDEATSALDTE-SEKVVQEALDK--AREGRTCIVIAHRLSTIQNADLIVVFQN 1247
Query: 888 GSVLREGT 895
G V GT
Sbjct: 1248 GRVKEHGT 1255
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 207 bits (526), Expect = 8e-53
Identities = 225/933 (24%), Positives = 411/933 (44%), Gaps = 125/933 (13%)
Query: 678 YFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 735
+FS+ S + L +++++ +GQ +VG GCGKS+ + I EG ++
Sbjct: 400 HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDG-- 457
Query: 736 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPD 793
+ +F R V +Q+P L + T+ ENI +G + + KAV +A + +
Sbjct: 458 QDIRNFNVNYLREIIGVV--SQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE-F 514
Query: 794 IDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE 853
I LP T +GERG LSGGQ+QRI +ARAL +N I+ LD+ SALD S+ +Q
Sbjct: 515 IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAEVQA 573
Query: 854 GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHW 910
+ K + RT +++ H+L + +AD I +DG ++ +G+ ++ K+ +L
Sbjct: 574 ALDKAREG--RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
Query: 911 KTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----N 966
+ Q +E E + E T + + ++ + +++ ++ + E D N
Sbjct: 632 TSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEAN 691
Query: 967 MSTVMRLRTKMPWKTCWRY--------LTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 1018
+ V L+ KT W Y + +GG +IFS+ I+AI
Sbjct: 692 VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSE------IIAI------- 738
Query: 1019 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK-------NLHHN 1071
G D +I +FL +++ T G T K L
Sbjct: 739 --------FGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSM 790
Query: 1072 LLNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMIS 1129
++ + +FD G + R + D + Q T +L + L +IS
Sbjct: 791 AFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALIAQNIANLGTGIIIS 849
Query: 1130 YA----TPVFLVALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLT 1183
+ + L+A++P+ ++ A +D +EL+ + ++ +E E +
Sbjct: 850 FIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIA-----TEAIENIR 904
Query: 1184 TIRAFRHETRFKQRMLE-----------------LTDTNNIAYLFLSAANRWLEVRTDYL 1226
T+ + E +F+ +E +T + + A+++ S A +
Sbjct: 905 TVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFR------F 958
Query: 1227 GACIVLTA-----SIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKK 1281
GA +++ + + + G V LG +A + + A L +
Sbjct: 959 GAYLIVNGHMRFRDVILVFSAIVFGAVALG--HASSFAPDYAKAKLSAAHLFMLFERQPL 1016
Query: 1282 VNSFLT--MESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPG 1339
++S+ ++ + +EG + ++V ++P + PVL+ + +K G
Sbjct: 1017 IDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV--------------PVLQGLSLEVKKG 1062
Query: 1340 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKI-------VIDGIDISKLPLHTLRSRLSII 1392
Q + + G +G GKS++ R D G + ++DG + KL + LR++L I+
Sbjct: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIV 1122
Query: 1393 LQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENF 1449
Q+PILF SI N+ D + D + A + A + +++LP + V + G
Sbjct: 1123 SQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQL 1182
Query: 1450 SVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSS 1509
S GQ+Q +ARA +R+ IL++DEAT+++D +E ++Q+ + A RT + IAHR+S+
Sbjct: 1183 SGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1242
Query: 1510 IMDAGLVLVFSEGILVECDTVPNLLAHKNGLFS 1542
I +A L++VF G + E T LLA K FS
Sbjct: 1243 IQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFS 1275
Score = 125 bits (314), Expect = 3e-28
Identities = 79/240 (32%), Positives = 134/240 (55%), Gaps = 5/240 (2%)
Query: 1309 EGEIKIHDLCVRYEN--NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIF 1366
+G ++ +D+ Y + N+K +LK + ++ GQ V + G +G GKS+ R+ D
Sbjct: 391 KGNLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD 449
Query: 1367 DGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIA 1425
+G I IDG DI ++ LR + ++ Q+P+LFS +I N+ T D + +A++ A
Sbjct: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
Query: 1426 QLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN 1485
+ LP D +V E G S GQ+Q +ARA VR IL++DEAT+++D +E
Sbjct: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
Query: 1486 ILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
+Q + A RT + IAHR+S++ +A ++ F +G++VE + L+ K G++ LV
Sbjct: 570 EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
Score = 104 bits (259), Expect = 8e-22
Identities = 71/251 (28%), Positives = 127/251 (50%), Gaps = 12/251 (4%)
Query: 652 LDSYEQSTRRLRPAETE-DIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCG 710
+DSY S L+P + E +I + + + L + + + GQ +VG GCG
Sbjct: 1017 IDSY--SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCG 1074
Query: 711 KSSLLLAILGEMQTLEGKVHWS---NVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVE 767
KS+++ + L G V + + + + + R + +Q+P L + ++
Sbjct: 1075 KSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1134
Query: 768 ENITFGSP---FNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVAR 824
ENI +G ++ + A ++ P I+ LP +T +G++G LSGGQ+QRI +AR
Sbjct: 1135 ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR 1194
Query: 825 ALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIA 884
AL + I+ LD+ SALD S+ ++QE + K + RT +++ H+L + +AD I+
Sbjct: 1195 ALIRQPQILLLDEATSALDTE-SEKVVQEALDK--AREGRTCIVIAHRLSTIQNADLIVV 1251
Query: 885 MKDGSVLREGT 895
++G V GT
Sbjct: 1252 FQNGRVKEHGT 1262
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 199 bits (505), Expect = 2e-50
Identities = 224/914 (24%), Positives = 392/914 (42%), Gaps = 89/914 (9%)
Query: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
L+++++ I G++T +VG G GKS+ L I EG V + + + R +
Sbjct: 438 LNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQ 497
Query: 748 NRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEI 805
+ Q+P L + T+ ENI +G + +A +A + +DL P T +
Sbjct: 498 ----IGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDL-PQQFDTLV 552
Query: 806 GERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRT 865
GE G +SGGQ+QR+ +ARAL +N I+ LD SALD + S+ ++QE + K T
Sbjct: 553 GEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSKIQHG--HT 609
Query: 866 LVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKD- 924
++ V H+L + AD II + G+ + GT +++ + +Y TL ++ +Q L ++
Sbjct: 610 IISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERK-GVYFTLVTLQSQGNQALNEED 668
Query: 925 -MEADQTTLERKTLRRAMYSREAKAQMEDE-----------------DEEEEEEEDEDDN 966
+A + + +T R Y +A + D + EED D
Sbjct: 669 IKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDK 728
Query: 967 MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINN 1026
V P + ++ ++L+ + + +V + + +SI +
Sbjct: 729 DIPVQEEVEPAPVRRILKFSAPEWPYMLVGSV-GAAVNGTVTPLYAFLFSQILGTFSIPD 787
Query: 1027 TGKADQTYYVAGFSILCGA----GIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIR 1082
K +Q + G +L A +F + G K L ++ I
Sbjct: 788 --KEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIA 845
Query: 1083 FFDT--TPLGLILNRFSADTNIID----QHIPPTLESLTRSTLLCLSAIGMISYATPVFL 1136
+FD G + R + D + + I + S T T+ + A S+ + +
Sbjct: 846 WFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSF-SWKLSLVI 904
Query: 1137 VALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF 1194
+ P Q AS+D Q L+ Q+ +E + T+ E RF
Sbjct: 905 LCFFPFLALSGATQTRMLTGFASRDKQALEMVGQIT-----NEALSNIRTVAGIGKERRF 959
Query: 1195 KQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLY 1254
+E +T L + + + G C I I+ S++ G
Sbjct: 960 ----IEALETE------LEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGY---- 1005
Query: 1255 ALTITN---YLNWVVRNLADLEVQMGAVKKVNSFLT------MESENYEGTMDP------ 1299
I+N + ++V R ++ + + A+ + S+ + + + +D
Sbjct: 1006 --LISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISV 1063
Query: 1300 -SQVPEHWPQ-EGEIKIHDLCVRYENNL-KPVLKHVKAYIKPGQKVGICGRTGSGKSSLS 1356
+ E W +G+I D Y + VL + I PGQ + G +G GKS+
Sbjct: 1064 YNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSI 1123
Query: 1357 LAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNL---DPECKC 1413
R D GK++IDG D K+ + LRS + I+ Q+P+LF+ SI N+ D +
Sbjct: 1124 QLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEI 1183
Query: 1414 TDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMD 1473
+R+ A + AQL + V SLP + V G S G++Q +ARA VR IL++D
Sbjct: 1184 PMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLD 1243
Query: 1474 EATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNL 1533
EAT+++D +E +Q + A RT + IAHR+S+I +A ++ V ++G+++E T L
Sbjct: 1244 EATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEEL 1303
Query: 1534 LAHKNGLFSTLVMT 1547
+A K G + LV T
Sbjct: 1304 MAQK-GAYYKLVTT 1316
Score = 134 bits (337), Expect = 7e-31
Identities = 79/239 (33%), Positives = 134/239 (56%), Gaps = 3/239 (1%)
Query: 1309 EGEIKIHDLCVRYENNLK-PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFD 1367
+GEI+ H++ Y + + +L + IKPG+ + G +G+GKS+ R D +
Sbjct: 417 KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCE 476
Query: 1368 GKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECK-CTDDRLWEALEIAQ 1426
G + +DG DI L + LR ++ I+ Q+P+LFS +I N+ + T + + +A + A
Sbjct: 477 GMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEAN 536
Query: 1427 LKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENI 1486
N + LP D +V EGG S GQ+Q +ARA +R IL++D AT+++D +E +
Sbjct: 537 AYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAM 596
Query: 1487 LQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
+Q+V+ T++++AHR+S++ A ++ F G VE T LL K G++ TLV
Sbjct: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERK-GVYFTLV 654
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 190 bits (482), Expect = 1e-47
Identities = 197/823 (23%), Positives = 363/823 (44%), Gaps = 65/823 (7%)
Query: 749 RYSVAYAAQKPWLLNATVEENITFGSP--FNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 806
R + +Q+P L T+ NI +G +++ +A +A + ++ P T +G
Sbjct: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEF-PNKFNTLVG 74
Query: 807 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 866
E+G +SGGQ+QRI +ARAL +N I+ LD+ SALD S +Q + K + RT
Sbjct: 75 EKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKG--RTT 131
Query: 867 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDME 926
++V H+L + AD I+ +KDG + +G ++ K Y +M++ ++ ++ ME
Sbjct: 132 IVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYS---LVMSQDIKKADEQME 188
Query: 927 ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 986
+ + ERKT ++S ++ + + D+ EE + ++ ++ V L+ K W ++
Sbjct: 189 SMTYSTERKTNSLPLHSVKS-IKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFV 247
Query: 987 TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINN--TGKADQTYYVAGFSILCG 1044
G + +L +V A + + N+ T K D Y F IL
Sbjct: 248 VLG--------TLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGV 299
Query: 1045 AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDT--TPLGLILNRFSADTNI 1102
+ L G L H ++ I +FD G + + D
Sbjct: 300 ICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQ 359
Query: 1103 IDQHIPPTLESLTRS-TLLCLSAIGMISYATPV--FLVALLPLGVAFYFIQKYFRV--AS 1157
I + LT++ T + LS I Y + ++++ P+ I+ A+
Sbjct: 360 IQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFAN 419
Query: 1158 KDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANR 1217
KD QEL + ++ +E E + TI + E F+Q E+ T + R
Sbjct: 420 KDKQELKHAGKIA-----TEALENIRTIVSLTREKAFEQMYEEMLQTQH----------R 464
Query: 1218 WLEVRTDYLGACIVLTASIASISGSSN----------SGLVGLGLLYALTITNYLNWVVR 1267
+ +G+C + + + ++ + G+ T Y +
Sbjct: 465 NTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIG 524
Query: 1268 NLADLEVQMGAVKK--VNSFLTMESE-NYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENN 1324
L + K + F +E + N + + P+ EG ++ ++ Y
Sbjct: 525 ETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTC--EGNLEFREVSFFYP-- 580
Query: 1325 LKP---VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLP 1381
+P +L+ + I+ G+ V G +G GKS+ R+ D G+++ DG+D +L
Sbjct: 581 CRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELN 640
Query: 1382 LHTLRSRLSIILQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGL 1438
+ LRS+++I+ Q+P+LF+ SI N+ D D + EA A + + ++ LP
Sbjct: 641 VQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKY 700
Query: 1439 DAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADR 1498
+ V G S GQ+Q +ARA ++K IL++DEAT+++D +E ++Q + A R
Sbjct: 701 NTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGR 760
Query: 1499 TVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLF 1541
T + + HR+S+I +A L++V G + E T LL +++ F
Sbjct: 761 TCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYF 803
Score = 108 bits (270), Expect = 4e-23
Identities = 132/557 (23%), Positives = 240/557 (43%), Gaps = 67/557 (12%)
Query: 353 VLAVLLFLALILQRTFL-QASYYVTIETGINLRG-ALLAMIYNKILRLSTSNLSMGEMTL 410
+L V+ F++ +Q F +A +T+ LR A AM+Y I S G +T
Sbjct: 296 ILGVICFVSYFMQGLFYGRAGEILTMR----LRHLAFKAMLYQDIAWFDEKENSTGGLTT 351
Query: 411 GQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQ 470
++ I+ L N M + +I+ I + + + A V+ + I+
Sbjct: 352 ILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSI-APVLAVTGMIE 410
Query: 471 YFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEET-RMKELSSL 529
T A K L ++ K E L+ I+ + E F + EE + + ++
Sbjct: 411 TAAMTGFANKDKQELKHAG---KIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTS 467
Query: 530 KTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTP--LFL 587
K + S F +A F+ AYA+G F + + +TP +F+
Sbjct: 468 KKAQIIGSCYAFSHA----------FIYFAYAAGFR------FGAYLIQAGRMTPEGMFI 511
Query: 588 LSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSL--PFESCKKHTGVQPKTINRK 645
+ T + + AI GE+ + P S K + K
Sbjct: 512 VFTAIAYGAMAI----------------------GETLVLAPEYSKAKSGAAHLFALLEK 549
Query: 646 QPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVG 705
+P ++DS Q ++ E ++ + + ++ + L + + I G+ VG
Sbjct: 550 KP---NIDSRSQEGKKPDTCEG-NLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVG 605
Query: 706 QVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNAT 765
GCGKS+ + + ++G+V + V+ E + + RS+ +A Q+P L N +
Sbjct: 606 SSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQ----IAIVPQEPVLFNCS 661
Query: 766 VEENITFGSPFNK---QRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICV 822
+ ENI +G K +A ++ I+ LP T++G +G LSGGQ+QR+ +
Sbjct: 662 IAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAI 721
Query: 823 ARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWI 882
ARAL Q I+ LD+ SALD + S+ ++Q + K RT ++VTH+L + +AD I
Sbjct: 722 ARALLQKPKILLLDEATSALD-NDSEKVVQHALDK--ARTGRTCLVVTHRLSAIQNADLI 778
Query: 883 IAMKDGSVLREGTLKDI 899
+ + +G + +GT +++
Sbjct: 779 VVLHNGKIKEQGTHQEL 795
Score = 100 bits (250), Expect = 8e-21
Identities = 58/178 (32%), Positives = 97/178 (54%), Gaps = 2/178 (1%)
Query: 1371 VIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIAQLKN 1429
++D DI L + R + ++ Q+P+LF +I N+ TD+ + A A +
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
Query: 1430 MVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQK 1489
+ P + +V E G S GQ+Q +ARA VR ILI+DEAT+++D +++ +Q
Sbjct: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
Query: 1490 VVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMT 1547
+ A RT + +AHR+S+I A L++ +G+L E L+A K GL+ +LVM+
Sbjct: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMA-KRGLYYSLVMS 177
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B isoform
1 [Homo sapiens]
Length = 703
Score = 161 bits (407), Expect = 5e-39
Identities = 147/580 (25%), Positives = 267/580 (46%), Gaps = 36/580 (6%)
Query: 957 EEEEEDEDDNMSTVMRL----RTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAID 1012
+E+E+D+ +N + RL R +P L + FFL++ ++ L+ H ID
Sbjct: 125 QEKEQDQVNNKVLMWRLLKLSRPDLP------LLVAAFFFLVLAVLGETLIPHYSGRVID 178
Query: 1013 YWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNL 1072
+ + + + S C G F ++ + + + L
Sbjct: 179 ILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLR---------IREQL 229
Query: 1073 LNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIG-MISYA 1131
+ ++ + FF T G + +R S+DT ++ +P L RS + + G M+S +
Sbjct: 230 FSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSIS 289
Query: 1132 TPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHE 1191
+ L++LL + + Y + L+E+ D+ E GL T+R+F E
Sbjct: 290 PRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQV-VREAVGGLQTVRSFGAE 348
Query: 1192 TRFKQRMLELTDTNNIAYLF--LSAANRWLEVRTDYLGA-CIVLTASIASIS-GSSNSGL 1247
R E + Y L A L R +LG ++L+ + + G G
Sbjct: 349 EHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGS 408
Query: 1248 VGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE-NYEGTMDPSQVPEHW 1306
+ ++Y ++ +Y+ +V D+ +GA +KV S++ + GT+ P+ +
Sbjct: 409 LLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTL---- 464
Query: 1307 PQEGEIKIHDLCVRYENNL-KPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDI 1365
+G +K D+ Y N +PVLK + ++PG+ + G GSGKS+++ +
Sbjct: 465 --QGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQP 522
Query: 1366 FDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECK-CTDDRLWEALEI 1424
G++++D IS+ L S++ + Q+P+LFSGS+R N+ + C DD++ A +
Sbjct: 523 TGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQA 582
Query: 1425 AQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE 1484
A + ++ + G+ V E G + GQ+Q +ARA VR +LI+DEAT+++D+ E
Sbjct: 583 AHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
Query: 1485 NILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGIL 1524
LQ + DRTV+ IAHR+ ++ A +LV EG L
Sbjct: 643 QALQD--WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
Score = 84.7 bits (208), Expect = 6e-16
Identities = 54/214 (25%), Positives = 104/214 (48%), Gaps = 10/214 (4%)
Query: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
L + + G++T +VG G GKS++ + Q G+V + + +P +
Sbjct: 486 LKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV----LLDEKPISQYEHCY 541
Query: 748 NRYSVAYAAQKPWLLNATVEENITFG-SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 806
V Q+P L + +V NI +G + A A I + G T++G
Sbjct: 542 LHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVG 601
Query: 807 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 866
E+G L+ GQ+QR+ +ARAL ++ ++ LD+ SALD+ ++ + + RT+
Sbjct: 602 EKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQ-----CEQALQDWNSRGDRTV 656
Query: 867 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 900
+++ H+LQ + A I+ +++G + + L++ Q
Sbjct: 657 LVIAHRLQAVQRAHQILVLQEGKLQKLAQLQEGQ 690
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 159 bits (401), Expect = 3e-38
Identities = 136/537 (25%), Positives = 243/537 (45%), Gaps = 61/537 (11%)
Query: 1045 AGIFLC-----LVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1099
+ +FLC + ++ G L +L + I+ + FFD T G ++NR S+D
Sbjct: 219 SAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSD 278
Query: 1100 TNIIDQHIPPTLESLTRSTLLCLSAIGMISYATP---VFLVALLP-LGVAFYFIQKYFRV 1155
T ++ + + L R+ I M+ + +P F+++++P + + +Y R
Sbjct: 279 TALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRK 338
Query: 1156 ASKDLQE-LDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSA 1214
+K Q+ L +TQL E + T+RAF E M E+ + +
Sbjct: 339 LTKVTQDSLAQATQLA-----EERIGNVRTVRAFGKE------MTEIEKYASKVDHVMQL 387
Query: 1215 ANRWLEVRTDYLGAC------IVLTASIAS--ISGSSNS--GLVGLGLLYALTITNYLNW 1264
A + R + GA IVL+ + GS++ G + L+YA + +
Sbjct: 388 ARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGG 447
Query: 1265 VVRNLADLEVQMGAVKKV------------NSFLTMESENYEGTMDPSQVPEHWPQEGEI 1312
+ ++L +GA ++ N + + ++++G ++ V +P E+
Sbjct: 448 LSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEV 507
Query: 1313 KIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1372
P+ + I G + G +GSGKS++ R+ D G I +
Sbjct: 508 --------------PIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISL 553
Query: 1373 DGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNL----DPECKCTDDRLWEALEIAQLK 1428
DG DI +L LRS++ + Q+PILFS SI N+ D T + + E+A
Sbjct: 554 DGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAV 613
Query: 1429 NMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQ 1488
+++ P G + VV E G S GQ+Q +ARA ++ IL++DEAT+++D E ++Q
Sbjct: 614 AFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQ 673
Query: 1489 KVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
+ + RTV+ IAHR+S+I +A +V V +G + E LL+ NG++ L+
Sbjct: 674 EALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLM 730
Score = 107 bits (268), Expect = 7e-23
Identities = 71/253 (28%), Positives = 135/253 (53%), Gaps = 16/253 (6%)
Query: 671 AIKVTNGYFSWGSG--LATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGK 728
A++ N +F++ + + + + IP+G +T +VG G GKS++L +L G
Sbjct: 491 ALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGT 550
Query: 729 VHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG----SPFNKQRYKAV 784
+ + + + RS+ + +Q+P L + ++ ENI +G S + + V
Sbjct: 551 ISLDGHDIRQLNPVWLRSK----IGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRV 606
Query: 785 TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDI 844
+ + I P G T +GE+G+ LSGGQ+QRI +ARAL +N I+ LD+ SALD
Sbjct: 607 AEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDA 666
Query: 845 HLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDV 904
+++L+QE + + + D RT++++ H+L + +A+ + + G + G +++ +K
Sbjct: 667 E-NEYLVQEALDRLM--DGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPN 723
Query: 905 ELYEHWKTLMNRQ 917
+Y + LMN+Q
Sbjct: 724 GIY---RKLMNKQ 733
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 150 bits (378), Expect = 1e-35
Identities = 131/510 (25%), Positives = 219/510 (42%), Gaps = 64/510 (12%)
Query: 71 LRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGF-VATTTSIVYYHNIE-TS 128
L W +++A LF + G R + P V+G + T ++ Y ++
Sbjct: 79 LLWCVSWADLFYSFHGLVHG------RAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQ 132
Query: 129 NFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCI--TGMMVILNGLLMAVEIN 186
+ L++ FL V A + K++ G RF ++L+ L++A
Sbjct: 133 SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILAC--- 189
Query: 187 VIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLK 246
R F + + V P + + LS+ +WW + I ++ P++ K
Sbjct: 190 ---FREKPPFFSAKNVDPNP--------YPETSAGFLSRLFFWWFTKMAIYGYRHPLEEK 238
Query: 247 AIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPN----------------------RTPS 284
+ L R+ L +A+ +Q+K+ A H R PS
Sbjct: 239 DLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPS 298
Query: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
A+ FG L+S+ F+ + DLL F P +S +++ IS ++
Sbjct: 299 FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRF-------------ISNPMAP 345
Query: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
+ +++A L+FL ++Q LQ Y+ TG+ R ++ +IY K L ++ S
Sbjct: 346 SWW---GFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKR 402
Query: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
T+G+I NL++++ + M LW+ P+QII+ + L+ LG S L G A +V
Sbjct: 403 AS--TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMV 460
Query: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
LL P+ +A K+ Q + R+K +EIL GIK+LKLYAWE F K VE R
Sbjct: 461 LLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQG 520
Query: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLAT 554
EL L+T A + + F P L T
Sbjct: 521 ELQLLRTAAYLHTTTTFTWMCSPFLVRLGT 550
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,246,015
Number of Sequences: 37866
Number of extensions: 2209580
Number of successful extensions: 18875
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 202
Number of HSP's successfully gapped in prelim test: 82
Number of HSP's that attempted gapping in prelim test: 14441
Number of HSP's gapped (non-prelim): 2511
length of query: 1549
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1433
effective length of database: 13,855,062
effective search space: 19854303846
effective search space used: 19854303846
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.