BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|16753212 src kinase associated phosphoprotein 2 [Homo sapiens] (359 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|16753212 src kinase associated phosphoprotein 2 [Homo sapiens] 742 0.0 gi|115527074 src kinase associated phosphoprotein 1 isoform 1 [H... 295 6e-80 gi|115527076 src kinase associated phosphoprotein 1 isoform 2 [H... 293 2e-79 gi|93102364 SWAP-70 protein [Homo sapiens] 53 4e-07 gi|11321634 CD2-associated protein [Homo sapiens] 52 8e-07 gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 52 1e-06 gi|224994221 SH3-domain binding protein 2 isoform b [Homo sapiens] 51 1e-06 gi|224994219 SH3-domain binding protein 2 isoform c [Homo sapiens] 51 1e-06 gi|170014705 SH3-domain binding protein 2 isoform a [Homo sapiens] 51 1e-06 gi|170014703 SH3-domain binding protein 2 isoform a [Homo sapiens] 51 1e-06 gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 51 1e-06 gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 51 1e-06 gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [... 50 3e-06 gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [... 50 3e-06 gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H... 50 3e-06 gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 50 4e-06 gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 50 4e-06 gi|154354979 myosin X [Homo sapiens] 49 5e-06 gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 49 7e-06 gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [H... 49 7e-06 gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 49 7e-06 gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho... 49 7e-06 gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens] 49 9e-06 gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens] 49 9e-06 gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens] 49 9e-06 gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens] 49 9e-06 gi|4758968 cytohesin 3 [Homo sapiens] 48 2e-05 gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H... 48 2e-05 gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 47 2e-05 gi|182765466 FCH and double SH3 domains 2 [Homo sapiens] 47 2e-05 >gi|16753212 src kinase associated phosphoprotein 2 [Homo sapiens] Length = 359 Score = 742 bits (1916), Expect = 0.0 Identities = 359/359 (100%), Positives = 359/359 (100%) Query: 1 MPNPSSTSSPYPLPEEIRNLLADVETFVADILKGENLSKKAKEKRESLIKKIKDVKSIYL 60 MPNPSSTSSPYPLPEEIRNLLADVETFVADILKGENLSKKAKEKRESLIKKIKDVKSIYL Sbjct: 1 MPNPSSTSSPYPLPEEIRNLLADVETFVADILKGENLSKKAKEKRESLIKKIKDVKSIYL 60 Query: 61 QEFQDKGDAEDGEEYDDPFAGPPDTISLASERYDKDDEAPSDGAQFPPIAAQDLPFVLKA 120 QEFQDKGDAEDGEEYDDPFAGPPDTISLASERYDKDDEAPSDGAQFPPIAAQDLPFVLKA Sbjct: 61 QEFQDKGDAEDGEEYDDPFAGPPDTISLASERYDKDDEAPSDGAQFPPIAAQDLPFVLKA 120 Query: 121 GYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKD 180 GYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKD Sbjct: 121 GYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKD 180 Query: 181 GKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDV 240 GKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDV Sbjct: 181 GKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDV 240 Query: 241 DHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYAN 300 DHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYAN Sbjct: 241 DHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYAN 300 Query: 301 FYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI 359 FYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI Sbjct: 301 FYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI 359 >gi|115527074 src kinase associated phosphoprotein 1 isoform 1 [Homo sapiens] Length = 359 Score = 295 bits (754), Expect = 6e-80 Identities = 159/369 (43%), Positives = 224/369 (60%), Gaps = 40/369 (10%) Query: 13 LPEEIRNLLADVETFVADILKGENLSKKAKEKRESLIKKIKDVKSIYLQEFQDKGDAEDG 72 LPEEIR LL D E F+A+ L+ ENLS A++ R+ +++ + +K+ Y +FQ +G Sbjct: 6 LPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQ 65 Query: 73 EEYDDPFAGPPDTISLASER---YDKDDEAPSDGAQFPPIAAQDLPFVLKAGYLEKRRKD 129 + DD +G +SL S+ D DE D + AQ+L V+K GYLEK+ KD Sbjct: 66 DSSDDNHSGTLG-LSLTSDAPFLSDYQDEGMEDIVK----GAQELDNVIKQGYLEKKSKD 120 Query: 130 HSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEI 189 HSF G EWQKRWC +S+ +FYYY ++K KQ KG F I GY VRM LR+D KK+ CFE+ Sbjct: 121 HSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFEL 180 Query: 190 SAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIP----EDYDERGELYDDVD---- 241 ++ D+R Y+FTA SP +A +WV Q+ F+L+D+ S IP E+ +E+ E YDD+D Sbjct: 181 TSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDS 240 Query: 242 -------HPLPISNPLTSSQPI----DDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHT 290 P + + +P +++IYE LP+EE D +EE ++ Sbjct: 241 PSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHD-----LEEDESGTR------ 289 Query: 291 SGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPK 350 K DYA++YQGLWDC G DELSF+RGD+I ILSKEYN YGWWVGE+ +G+VPK Sbjct: 290 --RKGVDYASYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELNSLVGIVPK 347 Query: 351 AYIMEMYDI 359 Y+ +++ Sbjct: 348 EYLTTAFEV 356 >gi|115527076 src kinase associated phosphoprotein 1 isoform 2 [Homo sapiens] Length = 358 Score = 293 bits (750), Expect = 2e-79 Identities = 158/369 (42%), Positives = 224/369 (60%), Gaps = 41/369 (11%) Query: 13 LPEEIRNLLADVETFVADILKGENLSKKAKEKRESLIKKIKDVKSIYLQEFQDKGDAEDG 72 LPEEIR LL D E F+A+ L+ ENLS A++ R+ +++ + +K+ Y +FQ +G Sbjct: 6 LPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQ 65 Query: 73 EEYDDPFAGPPDTISLASER---YDKDDEAPSDGAQFPPIAAQDLPFVLKAGYLEKRRKD 129 + DD +G +SL S+ D DE D + AQ+L V+K GYLEK+ KD Sbjct: 66 DSSDDNHSGTLG-LSLTSDAPFLSDYQDEGMEDIVK----GAQELDNVIKQGYLEKKSKD 120 Query: 130 HSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEI 189 HSF G EWQKRWC +S+ +FYYY ++K KQ KG F I GY VRM LR+D KK+ CFE+ Sbjct: 121 HSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFEL 180 Query: 190 SAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIP----EDYDERGELYDDVD---- 241 ++ D+R Y+FTA SP +A +WV Q+ F+L+D+ S IP E+ +E+ E YDD+D Sbjct: 181 TSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDS 240 Query: 242 -------HPLPISNPLTSSQPI----DDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHT 290 P + + +P +++IYE LP+EE D +EE ++ Sbjct: 241 PSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHD-----LEEDESGTR------ 289 Query: 291 SGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPK 350 + DYA++YQGLWDC G DELSF+RGD+I ILSKEYN YGWWVGE+ +G+VPK Sbjct: 290 ---RKGDYASYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELNSLVGIVPK 346 Query: 351 AYIMEMYDI 359 Y+ +++ Sbjct: 347 EYLTTAFEV 355 >gi|93102364 SWAP-70 protein [Homo sapiens] Length = 585 Score = 53.1 bits (126), Expect = 4e-07 Identities = 49/181 (27%), Positives = 83/181 (45%), Gaps = 20/181 (11%) Query: 117 VLKAGYLEK---RRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRM 173 VLK GY+ K RRK+ W +RW L + YY S+ K +KG+ +D + + Sbjct: 211 VLKQGYMMKKGHRRKN-------WTERWFVLKPNIISYYVSEDLKDKKGDILLD-ENCCV 262 Query: 174 NNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIP---EDY 230 + KDGKK C F + DK ++ +A+ K +EW+Q + + ++ P E Sbjct: 263 ESLPDKDGKK-CLFLVKCFDK-TFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEAR 320 Query: 231 DERGEL-YDDVDHPLPISNPLTSSQPIDDEIYEELP---EEEEDSAPVKVEEQRKMSQDS 286 R EL + + + Q ++ +EL ++ E++A EE++K Q Sbjct: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQ 380 Query: 287 V 287 V Sbjct: 381 V 381 >gi|11321634 CD2-associated protein [Homo sapiens] Length = 639 Score = 52.0 bits (123), Expect = 8e-07 Identities = 25/95 (26%), Positives = 50/95 (52%), Gaps = 1/95 (1%) Query: 266 EEEEDSAPVKVEEQRKMSQD-SVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVI 324 EE++ P+ ++ +Q + T + + + L+ G DEL+FK G++I Sbjct: 237 EEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEII 296 Query: 325 YILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI 359 +++SKE GWW GE+ G G+ P + +++ ++ Sbjct: 297 HLISKETGEAGWWRGELNGKEGVFPDNFAVQINEL 331 Score = 36.2 bits (82), Expect = 0.047 Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 2/43 (4%) Query: 314 DELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEM 356 DEL K GD+I I E GWW G + +GL P ++ E+ Sbjct: 125 DELELKVGDIIDI--NEEVEEGWWSGTLNNKLGLFPSNFVKEL 165 Score = 32.0 bits (71), Expect = 0.88 Identities = 15/51 (29%), Positives = 27/51 (52%), Gaps = 1/51 (1%) Query: 306 WDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEM 356 +D DEL+ + G++I + K+ GW GE+ G G+ P ++ E+ Sbjct: 8 YDYDAVHDDELTIRVGEIIRNV-KKLQEEGWLEGELNGRRGMFPDNFVKEI 57 >gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] Length = 845 Score = 51.6 bits (122), Expect = 1e-06 Identities = 31/85 (36%), Positives = 44/85 (51%), Gaps = 7/85 (8%) Query: 273 PVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYN 332 P K E+R +S+ +V ST Y + +D ELS K GD+I IL+K+ Sbjct: 764 PFKEPEKRTISRPAVG------STKYFGTAKARYDFCARDRSELSLKEGDIIKILNKK-G 816 Query: 333 RYGWWVGEMKGAIGLVPKAYIMEMY 357 + GWW GE+ G +G P Y+ E Y Sbjct: 817 QQGWWRGEIYGRVGWFPANYVEEDY 841 Score = 29.3 bits (64), Expect = 5.7 Identities = 20/59 (33%), Positives = 28/59 (47%), Gaps = 10/59 (16%) Query: 223 SDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRK 281 SD I + +E +LYD V++ + DEIYE+L E S P K+ E K Sbjct: 146 SDQIDDTVEEDEDLYDCVEN----------EEAEGDEIYEDLMRSEPVSMPPKMTEYDK 194 >gi|224994221 SH3-domain binding protein 2 isoform b [Homo sapiens] Length = 618 Score = 51.2 bits (121), Expect = 1e-06 Identities = 45/162 (27%), Positives = 72/162 (44%), Gaps = 13/162 (8%) Query: 117 VLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNT 176 V KAGYL K+ L +W R+ + K YY+ S +G F++ GY+ M Sbjct: 84 VAKAGYLHKKGGTQLQL-LKWPLRFVIIHKRCVYYFKSSTSASPQGAFSLSGYNRVMRAA 142 Query: 177 LRKDGKKDCCFEISAPDK--RIYQFTAASPKDAEEWVQQLKFVLQDM-ESDIIPEDYDER 233 F+I K R + F+A+S ++ + W+ L+ + E +P D + Sbjct: 143 EETTSNNVFPFKIIHISKKHRTWFFSASSEEERKSWMALLRREIGHFHEKKDLPLDTSDS 202 Query: 234 G----ELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDS 271 Y V+ P+ IS S P D+E YE ++E+DS Sbjct: 203 SSDTDSFYGAVERPVDIS---LSPYPTDNEDYEH--DDEDDS 239 >gi|224994219 SH3-domain binding protein 2 isoform c [Homo sapiens] Length = 589 Score = 51.2 bits (121), Expect = 1e-06 Identities = 45/162 (27%), Positives = 72/162 (44%), Gaps = 13/162 (8%) Query: 117 VLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNT 176 V KAGYL K+ L +W R+ + K YY+ S +G F++ GY+ M Sbjct: 55 VAKAGYLHKKGGTQLQL-LKWPLRFVIIHKRCVYYFKSSTSASPQGAFSLSGYNRVMRAA 113 Query: 177 LRKDGKKDCCFEISAPDK--RIYQFTAASPKDAEEWVQQLKFVLQDM-ESDIIPEDYDER 233 F+I K R + F+A+S ++ + W+ L+ + E +P D + Sbjct: 114 EETTSNNVFPFKIIHISKKHRTWFFSASSEEERKSWMALLRREIGHFHEKKDLPLDTSDS 173 Query: 234 G----ELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDS 271 Y V+ P+ IS S P D+E YE ++E+DS Sbjct: 174 SSDTDSFYGAVERPVDIS---LSPYPTDNEDYEH--DDEDDS 210 >gi|170014705 SH3-domain binding protein 2 isoform a [Homo sapiens] Length = 561 Score = 51.2 bits (121), Expect = 1e-06 Identities = 45/162 (27%), Positives = 72/162 (44%), Gaps = 13/162 (8%) Query: 117 VLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNT 176 V KAGYL K+ L +W R+ + K YY+ S +G F++ GY+ M Sbjct: 27 VAKAGYLHKKGGTQLQL-LKWPLRFVIIHKRCVYYFKSSTSASPQGAFSLSGYNRVMRAA 85 Query: 177 LRKDGKKDCCFEISAPDK--RIYQFTAASPKDAEEWVQQLKFVLQDM-ESDIIPEDYDER 233 F+I K R + F+A+S ++ + W+ L+ + E +P D + Sbjct: 86 EETTSNNVFPFKIIHISKKHRTWFFSASSEEERKSWMALLRREIGHFHEKKDLPLDTSDS 145 Query: 234 G----ELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDS 271 Y V+ P+ IS S P D+E YE ++E+DS Sbjct: 146 SSDTDSFYGAVERPVDIS---LSPYPTDNEDYEH--DDEDDS 182 >gi|170014703 SH3-domain binding protein 2 isoform a [Homo sapiens] Length = 561 Score = 51.2 bits (121), Expect = 1e-06 Identities = 45/162 (27%), Positives = 72/162 (44%), Gaps = 13/162 (8%) Query: 117 VLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNT 176 V KAGYL K+ L +W R+ + K YY+ S +G F++ GY+ M Sbjct: 27 VAKAGYLHKKGGTQLQL-LKWPLRFVIIHKRCVYYFKSSTSASPQGAFSLSGYNRVMRAA 85 Query: 177 LRKDGKKDCCFEISAPDK--RIYQFTAASPKDAEEWVQQLKFVLQDM-ESDIIPEDYDER 233 F+I K R + F+A+S ++ + W+ L+ + E +P D + Sbjct: 86 EETTSNNVFPFKIIHISKKHRTWFFSASSEEERKSWMALLRREIGHFHEKKDLPLDTSDS 145 Query: 234 G----ELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDS 271 Y V+ P+ IS S P D+E YE ++E+DS Sbjct: 146 SSDTDSFYGAVERPVDIS---LSPYPTDNEDYEH--DDEDDS 182 >gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] Length = 397 Score = 51.2 bits (121), Expect = 1e-06 Identities = 26/100 (26%), Positives = 47/100 (47%), Gaps = 25/100 (25%) Query: 137 WQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKR- 195 W++RW L+ YY+ DK+ +G ++ S+R +D KK CFE+ PD + Sbjct: 277 WKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIRE----VEDSKKPNCFELYIPDNKD 332 Query: 196 --------------------IYQFTAASPKDAEEWVQQLK 215 +Y+ +A +P++ EEW++ +K Sbjct: 333 QVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIK 372 >gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] Length = 398 Score = 51.2 bits (121), Expect = 1e-06 Identities = 26/100 (26%), Positives = 47/100 (47%), Gaps = 25/100 (25%) Query: 137 WQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKR- 195 W++RW L+ YY+ DK+ +G ++ S+R +D KK CFE+ PD + Sbjct: 278 WKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIRE----VEDSKKPNCFELYIPDNKD 333 Query: 196 --------------------IYQFTAASPKDAEEWVQQLK 215 +Y+ +A +P++ EEW++ +K Sbjct: 334 QVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIK 373 >gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [Homo sapiens] Length = 438 Score = 50.1 bits (118), Expect = 3e-06 Identities = 32/130 (24%), Positives = 59/130 (45%), Gaps = 4/130 (3%) Query: 109 IAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDG 168 I+ +DL G+L K+++ SFL +W+K W L + Y+Y + ++ G + Sbjct: 35 ISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPD 94 Query: 169 YSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPE 228 ++V + KK F+IS P + + F A + ++ W+ +L + ES E Sbjct: 95 FTVER----ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDE 150 Query: 229 DYDERGELYD 238 + E D Sbjct: 151 ECYSESEQED 160 >gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [Homo sapiens] Length = 438 Score = 50.1 bits (118), Expect = 3e-06 Identities = 32/130 (24%), Positives = 59/130 (45%), Gaps = 4/130 (3%) Query: 109 IAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDG 168 I+ +DL G+L K+++ SFL +W+K W L + Y+Y + ++ G + Sbjct: 35 ISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPD 94 Query: 169 YSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPE 228 ++V + KK F+IS P + + F A + ++ W+ +L + ES E Sbjct: 95 FTVER----ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDE 150 Query: 229 DYDERGELYD 238 + E D Sbjct: 151 ECYSESEQED 160 >gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo sapiens] Length = 437 Score = 50.1 bits (118), Expect = 3e-06 Identities = 32/130 (24%), Positives = 59/130 (45%), Gaps = 4/130 (3%) Query: 109 IAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDG 168 I+ +DL G+L K+++ SFL +W+K W L + Y+Y + ++ G + Sbjct: 34 ISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPD 93 Query: 169 YSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPE 228 ++V + KK F+IS P + + F A + ++ W+ +L + ES E Sbjct: 94 FTVER----ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDE 149 Query: 229 DYDERGELYD 238 + E D Sbjct: 150 ECYSESEQED 159 >gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] Length = 1220 Score = 49.7 bits (117), Expect = 4e-06 Identities = 27/66 (40%), Positives = 37/66 (56%), Gaps = 4/66 (6%) Query: 290 TSGDKSTDYANFYQ--GLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGL 347 T KST A Q G++D T DEL+F +G +I +L+KE WW GE+ G +GL Sbjct: 1146 TEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKE--DPDWWKGEVNGQVGL 1203 Query: 348 VPKAYI 353 P Y+ Sbjct: 1204 FPSNYV 1209 Score = 36.2 bits (82), Expect = 0.047 Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 3/51 (5%) Query: 303 QGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYI 353 Q L+ + L+F + DVI +L ++ WW GE++G G PK+Y+ Sbjct: 919 QALYPWRAKKDNHLNFNKNDVITVLEQQDM---WWFGEVQGQKGWFPKSYV 966 Score = 32.0 bits (71), Expect = 0.88 Identities = 13/39 (33%), Positives = 23/39 (58%), Gaps = 3/39 (7%) Query: 315 ELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYI 353 +L+F++GDVI + K+ + WW G + G+ P Y+ Sbjct: 1020 DLTFQQGDVILVTKKDGD---WWTGTVGDKAGVFPSNYV 1055 Score = 31.6 bits (70), Expect = 1.2 Identities = 15/57 (26%), Positives = 27/57 (47%), Gaps = 5/57 (8%) Query: 301 FYQGLWDCTGAFSDELSFKRGDVIYILSK-----EYNRYGWWVGEMKGAIGLVPKAY 352 +Y+ L+ DE++ + GD++ + + + GW GE+KG G P Y Sbjct: 744 YYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANY 800 >gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] Length = 1721 Score = 49.7 bits (117), Expect = 4e-06 Identities = 27/66 (40%), Positives = 37/66 (56%), Gaps = 4/66 (6%) Query: 290 TSGDKSTDYANFYQ--GLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGL 347 T KST A Q G++D T DEL+F +G +I +L+KE WW GE+ G +GL Sbjct: 1146 TEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKE--DPDWWKGEVNGQVGL 1203 Query: 348 VPKAYI 353 P Y+ Sbjct: 1204 FPSNYV 1209 Score = 36.2 bits (82), Expect = 0.047 Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 3/51 (5%) Query: 303 QGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYI 353 Q L+ + L+F + DVI +L ++ WW GE++G G PK+Y+ Sbjct: 919 QALYPWRAKKDNHLNFNKNDVITVLEQQDM---WWFGEVQGQKGWFPKSYV 966 Score = 32.0 bits (71), Expect = 0.88 Identities = 13/39 (33%), Positives = 23/39 (58%), Gaps = 3/39 (7%) Query: 315 ELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYI 353 +L+F++GDVI + K+ + WW G + G+ P Y+ Sbjct: 1020 DLTFQQGDVILVTKKDGD---WWTGTVGDKAGVFPSNYV 1055 Score = 31.6 bits (70), Expect = 1.2 Identities = 15/57 (26%), Positives = 27/57 (47%), Gaps = 5/57 (8%) Query: 301 FYQGLWDCTGAFSDELSFKRGDVIYILSK-----EYNRYGWWVGEMKGAIGLVPKAY 352 +Y+ L+ DE++ + GD++ + + + GW GE+KG G P Y Sbjct: 744 YYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANY 800 >gi|154354979 myosin X [Homo sapiens] Length = 2058 Score = 49.3 bits (116), Expect = 5e-06 Identities = 34/117 (29%), Positives = 58/117 (49%), Gaps = 8/117 (6%) Query: 118 LKAGYLEKRRKDHSFLGFE-WQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNT 176 LK G+L K+ S L W+KRW L ++ Y+ +D +++ KG + ++NT Sbjct: 1214 LKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTVEVRTAKEIIDNT 1273 Query: 177 LRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDER 233 +++G +I D R + A SP+DA +W L V + + I E +DE+ Sbjct: 1274 TKENG-----IDIIMAD-RTFHLIAESPEDASQWFSVLSQVHASTDQE-IQEMHDEQ 1323 >gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo sapiens] Length = 756 Score = 48.9 bits (115), Expect = 7e-06 Identities = 21/61 (34%), Positives = 35/61 (57%) Query: 294 KSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYI 353 ++ + Y+ L+D DEL+ +RGDV+ +LSK GWW GE +G G+ P ++ Sbjct: 178 QTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 237 Query: 354 M 354 + Sbjct: 238 L 238 Score = 32.3 bits (72), Expect = 0.67 Identities = 11/41 (26%), Positives = 25/41 (60%), Gaps = 2/41 (4%) Query: 313 SDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYI 353 +DEL + G+++ ++ + + GWW+G+ G +G P ++ Sbjct: 99 ADELKLQAGEIVEMIKEIED--GWWLGKKNGQLGAFPSNFV 137 Score = 28.5 bits (62), Expect = 9.7 Identities = 17/43 (39%), Positives = 22/43 (51%), Gaps = 1/43 (2%) Query: 314 DELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEM 356 DELS GDV+ + R GW GE G GL P+ + E+ Sbjct: 15 DELSLAPGDVVRQVRWVPAR-GWLRGEFGGRYGLFPERLVQEI 56 >gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [Homo sapiens] Length = 645 Score = 48.9 bits (115), Expect = 7e-06 Identities = 21/61 (34%), Positives = 35/61 (57%) Query: 294 KSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYI 353 ++ + Y+ L+D DEL+ +RGDV+ +LSK GWW GE +G G+ P ++ Sbjct: 67 QTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 126 Query: 354 M 354 + Sbjct: 127 L 127 >gi|145312241 differentially expressed in FDCP 6 homolog [Homo sapiens] Length = 631 Score = 48.9 bits (115), Expect = 7e-06 Identities = 29/103 (28%), Positives = 53/103 (51%), Gaps = 7/103 (6%) Query: 117 VLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNT 176 VLK GYL KR L W +RW L + Y+GS++ K+++G +D + + Sbjct: 217 VLKQGYLWKR----GHLRRNWAERWFQLQPSCLCYFGSEECKEKRGIIPLDAHCC-VEVL 271 Query: 177 LRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQ 219 +DGK+ C F + + R Y+ +A+ + +EW ++ ++ Sbjct: 272 PDRDGKR-CMFCVKTAN-RTYEMSASDTRQRQEWTAAIQMAIR 312 >gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo sapiens] Length = 1034 Score = 48.9 bits (115), Expect = 7e-06 Identities = 42/194 (21%), Positives = 81/194 (41%), Gaps = 9/194 (4%) Query: 95 KDDEAPSDGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGS 154 K ++ P G I+ +DL G+L K++ S+ +W+K W L Y+Y + Sbjct: 549 KKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYIN 608 Query: 155 DKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQL 214 ++D++ +G ++ + + + R K F+ P + + F A D W+ ++ Sbjct: 609 EEDEKAEGFISLPEFKIDRASECR----KKYAFKACHPKIKSFYFAAEHLDDMNRWLNRI 664 Query: 215 KFVLQD-MESDIIPEDYDERGEL-YDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSA 272 + E + I ++ D E ++ D P S P S P + Y P S Sbjct: 665 NMLTAGYAERERIKQEQDYWSESDKEEADTP---STPKQDSPPPPYDTYPRPPSMSCASP 721 Query: 273 PVKVEEQRKMSQDS 286 V+ + R S ++ Sbjct: 722 YVEAKHSRLSSTET 735 >gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens] Length = 614 Score = 48.5 bits (114), Expect = 9e-06 Identities = 30/109 (27%), Positives = 57/109 (52%), Gaps = 13/109 (11%) Query: 246 ISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGL 305 + P + + E E+ EEED+ + EE+ K +S ++G++ Y + Sbjct: 49 VGAPTEEEEESESEDSEDSGGEEEDA---EEEEEEKEENESHKWSTGEE-------YIAV 98 Query: 306 WDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVG-EMKGAIGLVPKAYI 353 D T +L+FK+G+++ ++ K+ + GWW+ + KG GLVP+ Y+ Sbjct: 99 GDFTAQQVGDLTFKKGEILLVIEKKPD--GWWIAKDAKGNEGLVPRTYL 145 >gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens] Length = 677 Score = 48.5 bits (114), Expect = 9e-06 Identities = 30/109 (27%), Positives = 57/109 (52%), Gaps = 13/109 (11%) Query: 246 ISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGL 305 + P + + E E+ EEED+ + EE+ K +S ++G++ Y + Sbjct: 111 VGAPTEEEEESESEDSEDSGGEEEDA---EEEEEEKEENESHKWSTGEE-------YIAV 160 Query: 306 WDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVG-EMKGAIGLVPKAYI 353 D T +L+FK+G+++ ++ K+ + GWW+ + KG GLVP+ Y+ Sbjct: 161 GDFTAQQVGDLTFKKGEILLVIEKKPD--GWWIAKDAKGNEGLVPRTYL 207 >gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens] Length = 732 Score = 48.5 bits (114), Expect = 9e-06 Identities = 30/109 (27%), Positives = 57/109 (52%), Gaps = 13/109 (11%) Query: 246 ISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGL 305 + P + + E E+ EEED+ + EE+ K +S ++G++ Y + Sbjct: 111 VGAPTEEEEESESEDSEDSGGEEEDA---EEEEEEKEENESHKWSTGEE-------YIAV 160 Query: 306 WDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVG-EMKGAIGLVPKAYI 353 D T +L+FK+G+++ ++ K+ + GWW+ + KG GLVP+ Y+ Sbjct: 161 GDFTAQQVGDLTFKKGEILLVIEKKPD--GWWIAKDAKGNEGLVPRTYL 207 >gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens] Length = 733 Score = 48.5 bits (114), Expect = 9e-06 Identities = 30/109 (27%), Positives = 57/109 (52%), Gaps = 13/109 (11%) Query: 246 ISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGL 305 + P + + E E+ EEED+ + EE+ K +S ++G++ Y + Sbjct: 111 VGAPTEEEEESESEDSEDSGGEEEDA---EEEEEEKEENESHKWSTGEE-------YIAV 160 Query: 306 WDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVG-EMKGAIGLVPKAYI 353 D T +L+FK+G+++ ++ K+ + GWW+ + KG GLVP+ Y+ Sbjct: 161 GDFTAQQVGDLTFKKGEILLVIEKKPD--GWWIAKDAKGNEGLVPRTYL 207 >gi|4758968 cytohesin 3 [Homo sapiens] Length = 399 Score = 47.8 bits (112), Expect = 2e-05 Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 25/100 (25%) Query: 137 WQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKR- 195 W++RW L+ YY+ DK+ +G ++ S+R +D +K CFE+ P + Sbjct: 281 WKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIRE----VEDPRKPNCFELYNPSHKG 336 Query: 196 --------------------IYQFTAASPKDAEEWVQQLK 215 +Y+ +A SP++ EEW++ +K Sbjct: 337 QVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIK 376 >gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo sapiens] Length = 713 Score = 47.8 bits (112), Expect = 2e-05 Identities = 33/144 (22%), Positives = 59/144 (40%), Gaps = 18/144 (12%) Query: 121 GYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKD 180 G+L R+ F+G W++RW L Y+Y +D++ +G + YS+ + D Sbjct: 401 GWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGH----D 456 Query: 181 GKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVL--------------QDMESDII 226 KK F+++ + + F A + D WV+ L + +D S+ Sbjct: 457 QKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETE 516 Query: 227 PEDYDERGELYDDVDHPLPISNPL 250 ED D+ + P +PL Sbjct: 517 AEDPDDEAGSHSASPSPAQAGSPL 540 >gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 isoform c [Homo sapiens] Length = 1450 Score = 47.4 bits (111), Expect = 2e-05 Identities = 60/239 (25%), Positives = 97/239 (40%), Gaps = 36/239 (15%) Query: 4 PSSTSSPYPLPEEIR----NLLADVETFVADILKGEN------LSKKAKEKRESLIKKIK 53 P SP P P EI L + + D + E + K +E S + + Sbjct: 202 PPQPPSPPPCPPEIPPKPVRLFPEFDDSDYDEVPEEGPGAPARVMTKKEEPPPSRVPRAV 261 Query: 54 DVKSIYLQEFQDKGDAEDGEEYDD-PFAGPPD--------TISLASERYDKDDEAPSDGA 104 V S+ + + GD + EE DD + G P+ ++SL S P DG Sbjct: 262 RVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSLPSTIAAPH---PMDG- 317 Query: 105 QFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEF 164 PP + + V+KAG+L+K S++ +QKRW L Y+ S+KD K Sbjct: 318 --PPGGSTPVTPVIKAGWLDKNPPQGSYI---YQKRWVRLDTDHLRYFDSNKDAYSKRFI 372 Query: 165 AIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMES 223 ++ S D FE+ + R + F A S + +EW+Q L+ + + + Sbjct: 373 SVACIS-------HVAAIGDQKFEV-ITNNRTFAFRAESDVERKEWMQALQQAMAEQRA 423 Score = 41.2 bits (95), Expect = 0.001 Identities = 32/129 (24%), Positives = 53/129 (41%), Gaps = 7/129 (5%) Query: 114 LPFVLKAGYLEKRRKDHSFLGF-----EWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDG 168 LP V +G+L K L E+ +RWC L V Y+ +++ GE Sbjct: 741 LPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASE 800 Query: 169 YSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQL-KFVLQDMESDIIP 227 G + FE+ +R+Y F S + A EWV+ + K + + D++ Sbjct: 801 IVCLAVPPPDTHGFEH-TFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLA 859 Query: 228 EDYDERGEL 236 D++ G L Sbjct: 860 RDFERLGRL 868 >gi|182765466 FCH and double SH3 domains 2 [Homo sapiens] Length = 740 Score = 47.4 bits (111), Expect = 2e-05 Identities = 58/233 (24%), Positives = 91/233 (39%), Gaps = 40/233 (17%) Query: 137 WQKRWCALSKTVFYYYGSDKDKQQKGEF-----AIDGYSVRMNNTLRK---DGKKDCCFE 188 W + S + +D ++++ EF D S + TLR K ++ Sbjct: 422 WARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSYK 481 Query: 189 ISAPDKRIYQ----FTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPL 244 S PD+ + D E+WV+ V Q +PE Y + Sbjct: 482 ASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQ---VGYVPEKYLQ-----------F 527 Query: 245 PISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQG 304 P SN L S + + L + S + ++ S++ GD S F + Sbjct: 528 PTSNSLLS-------MLQSLAALDSRSHTSSNSTEAELVSGSLN---GDASVC---FVKA 574 Query: 305 LWDCTGAFSDELSFKRGDVIYILSKE-YNRYGWWVGEMKGAIGLVPKAYIMEM 356 L+D G DELSF G +I IL+KE + G+W GE G IG+ P + E+ Sbjct: 575 LYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEEL 627 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.134 0.400 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,258,711 Number of Sequences: 37866 Number of extensions: 762907 Number of successful extensions: 3431 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 122 Number of HSP's successfully gapped in prelim test: 224 Number of HSP's that attempted gapping in prelim test: 2979 Number of HSP's gapped (non-prelim): 544 length of query: 359 length of database: 18,247,518 effective HSP length: 103 effective length of query: 256 effective length of database: 14,347,320 effective search space: 3672913920 effective search space used: 3672913920 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.