BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] (1784 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] 3535 0.0 gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] 3522 0.0 gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens] 3429 0.0 gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2... 101 7e-21 gi|118600961 akt substrate AS250 [Homo sapiens] 101 7e-21 gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1... 100 2e-20 gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapi... 73 2e-12 gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapi... 73 2e-12 gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapi... 73 2e-12 gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform ... 68 9e-11 gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform ... 68 9e-11 gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sa... 67 2e-10 gi|112421013 signal-induced proliferation-associated 1 like 2 [H... 67 2e-10 gi|206725526 signal-induced proliferation-associated protein 1 [... 65 8e-10 gi|206725523 signal-induced proliferation-associated protein 1 [... 65 8e-10 gi|7662126 signal-induced proliferation-associated 1 like 1 [Hom... 65 8e-10 gi|71143119 signal-induced proliferation-associated 1 like 3 [Ho... 63 2e-09 gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 42 0.004 gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens] 42 0.007 gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens] 41 0.012 gi|145199237 transcription elongation factor B polypeptide 3 bin... 41 0.012 gi|95147555 microtubule-associated protein 1A [Homo sapiens] 40 0.020 gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo sap... 40 0.026 gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 40 0.026 gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 39 0.035 gi|223718207 ets variant gene 3 isoform 1 [Homo sapiens] 39 0.045 gi|33620755 YEATS domain containing 2 [Homo sapiens] 39 0.045 gi|163965366 nascent polypeptide-associated complex alpha subuni... 39 0.045 gi|157738619 smoothelin-like 1 [Homo sapiens] 39 0.045 gi|110611914 progesterone receptor [Homo sapiens] 38 0.077 >gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] Length = 1784 Score = 3535 bits (9167), Expect = 0.0 Identities = 1784/1784 (100%), Positives = 1784/1784 (100%) Query: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM Sbjct: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60 Query: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR Sbjct: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120 Query: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL Sbjct: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180 Query: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI Sbjct: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240 Query: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG Sbjct: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300 Query: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI Sbjct: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360 Query: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE Sbjct: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420 Query: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY Sbjct: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480 Query: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS Sbjct: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540 Query: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH Sbjct: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600 Query: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS Sbjct: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660 Query: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK Sbjct: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720 Query: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL Sbjct: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780 Query: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA Sbjct: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840 Query: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC Sbjct: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900 Query: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS Sbjct: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960 Query: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL Sbjct: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020 Query: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL Sbjct: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080 Query: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG Sbjct: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140 Query: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR Sbjct: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200 Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST Sbjct: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260 Query: 1261 AKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE 1320 AKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE Sbjct: 1261 AKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE 1320 Query: 1321 EKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD 1380 EKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD Sbjct: 1321 EKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD 1380 Query: 1381 KADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTI 1440 KADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTI Sbjct: 1381 KADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTI 1440 Query: 1441 SDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNE 1500 SDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNE Sbjct: 1441 SDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNE 1500 Query: 1501 SQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIE 1560 SQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIE Sbjct: 1501 SQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIE 1560 Query: 1561 LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1620 LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN Sbjct: 1561 LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1620 Query: 1621 DFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIV 1680 DFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIV Sbjct: 1621 DFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIV 1680 Query: 1681 SDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP 1740 SDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP Sbjct: 1681 SDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP 1740 Query: 1741 SLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV 1784 SLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV Sbjct: 1741 SLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV 1784 >gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] Length = 1807 Score = 3522 bits (9133), Expect = 0.0 Identities = 1784/1807 (98%), Positives = 1784/1807 (98%), Gaps = 23/1807 (1%) Query: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM Sbjct: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60 Query: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR Sbjct: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120 Query: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL Sbjct: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180 Query: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI Sbjct: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240 Query: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG Sbjct: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300 Query: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI Sbjct: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360 Query: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE Sbjct: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420 Query: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY Sbjct: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480 Query: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS Sbjct: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540 Query: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH Sbjct: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600 Query: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS Sbjct: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660 Query: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK Sbjct: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720 Query: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL Sbjct: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780 Query: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA Sbjct: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840 Query: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC Sbjct: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900 Query: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS Sbjct: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960 Query: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL Sbjct: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020 Query: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL Sbjct: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080 Query: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG Sbjct: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140 Query: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR Sbjct: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200 Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST Sbjct: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260 Query: 1261 AKPPPLPRSNT-----------------------DSAVVMEEGSPGEVPVLVEPPGLEDV 1297 AKPPPLPRSNT DSAVVMEEGSPGEVPVLVEPPGLEDV Sbjct: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320 Query: 1298 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1357 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ Sbjct: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380 Query: 1358 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1417 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ Sbjct: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440 Query: 1418 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1477 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV Sbjct: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500 Query: 1478 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1537 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA Sbjct: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560 Query: 1538 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1597 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH Sbjct: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620 Query: 1598 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1657 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC Sbjct: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680 Query: 1658 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1717 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW Sbjct: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740 Query: 1718 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1777 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV Sbjct: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800 Query: 1778 EDFTEFV 1784 EDFTEFV Sbjct: 1801 EDFTEFV 1807 >gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens] Length = 1740 Score = 3429 bits (8892), Expect = 0.0 Identities = 1740/1784 (97%), Positives = 1740/1784 (97%), Gaps = 44/1784 (2%) Query: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM Sbjct: 1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60 Query: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR Sbjct: 61 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120 Query: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL Sbjct: 121 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180 Query: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI Sbjct: 181 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240 Query: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG Sbjct: 241 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300 Query: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI Sbjct: 301 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360 Query: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE Sbjct: 361 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420 Query: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY Sbjct: 421 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480 Query: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS Sbjct: 481 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540 Query: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH Sbjct: 541 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600 Query: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS Sbjct: 601 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660 Query: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK Sbjct: 661 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720 Query: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL Sbjct: 721 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780 Query: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA Sbjct: 781 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840 Query: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC Sbjct: 841 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900 Query: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK Sbjct: 901 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK--------------- 945 Query: 961 PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020 RIQTSLTSASLGSADENSVAQADDSLKNLHL Sbjct: 946 -----------------------------RIQTSLTSASLGSADENSVAQADDSLKNLHL 976 Query: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL Sbjct: 977 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1036 Query: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG Sbjct: 1037 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1096 Query: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR Sbjct: 1097 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1156 Query: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST Sbjct: 1157 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1216 Query: 1261 AKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE 1320 AKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE Sbjct: 1217 AKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE 1276 Query: 1321 EKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD 1380 EKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD Sbjct: 1277 EKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD 1336 Query: 1381 KADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTI 1440 KADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTI Sbjct: 1337 KADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTI 1396 Query: 1441 SDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNE 1500 SDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNE Sbjct: 1397 SDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNE 1456 Query: 1501 SQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIE 1560 SQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIE Sbjct: 1457 SQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIE 1516 Query: 1561 LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1620 LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN Sbjct: 1517 LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1576 Query: 1621 DFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIV 1680 DFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIV Sbjct: 1577 DFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIV 1636 Query: 1681 SDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP 1740 SDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP Sbjct: 1637 SDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP 1696 Query: 1741 SLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV 1784 SLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV Sbjct: 1697 SLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV 1740 >gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2 [Homo sapiens] Length = 2083 Score = 101 bits (251), Expect = 7e-21 Identities = 71/266 (26%), Positives = 130/266 (48%), Gaps = 13/266 (4%) Query: 1497 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1556 L +++ R ++ LD +THKIAV YV EGQ + +IL+N GS Y +F+ GLG Sbjct: 1785 LLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKH-SILTNTGGSQAYEDFVAGLG 1843 Query: 1557 RLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1615 + L + C ++GGL G T + ++ +FH++T MP+ D D K Sbjct: 1844 WEVNLTNHCG----FMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPS-DSDDSLTKKL 1898 Query: 1616 RHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTS 1675 RHLGND V IV+++ D++ G I +F V +++ P+ + + + ++ Sbjct: 1899 RHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLF 1958 Query: 1676 VAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEA 1735 IV+ + LP + R A++A+ A + + +Y + + R R+++ + Q E Sbjct: 1959 DGAIVNGKVLPIMVRATAINASRALK------SLIPLYQNFYEERARYLQTIVQHHLEPT 2012 Query: 1736 AYSNPSLPLVHPPSHSKAPAQTPAEP 1761 + + + + P + P+ + P Sbjct: 2013 TFEDFAAQVFSPAPYHHLPSDAGSYP 2038 >gi|118600961 akt substrate AS250 [Homo sapiens] Length = 1873 Score = 101 bits (251), Expect = 7e-21 Identities = 66/211 (31%), Positives = 108/211 (51%), Gaps = 7/211 (3%) Query: 1490 ESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYT 1549 + K L ++ R ++ LD +THKIAV Y+ EGQ + + +ILSNE GS Y Sbjct: 1617 DRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQED-KCSILSNERGSQAYE 1675 Query: 1550 EFLTGLGRLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVD 1608 +F+ GLG ++L C ++GGL G GQ + ++ +FH++T MP+ D D Sbjct: 1676 DFVAGLGWEVDLSTHCG----FMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPS-DSD 1730 Query: 1609 KHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDM 1668 K RHLGND V IV+++ D++ G I F V +I+ P+ +++ + ++ Sbjct: 1731 DSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEV 1790 Query: 1669 EGLVDTSVAKIVSDRNLPFVARQMALHANMA 1699 IVS + LP + ++A+ A Sbjct: 1791 PFFGPLFDGAIVSGKLLPSLVCATCINASRA 1821 >gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1 [Homo sapiens] Length = 2036 Score = 99.8 bits (247), Expect = 2e-20 Identities = 70/260 (26%), Positives = 128/260 (49%), Gaps = 13/260 (5%) Query: 1497 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1556 L +++ R ++ LD +THKIAV YV EGQ + +IL+N GS Y +F+ GLG Sbjct: 1785 LLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKH-SILTNTGGSQAYEDFVAGLG 1843 Query: 1557 RLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1615 + L + C ++GGL G T + ++ +FH++T MP+ D D K Sbjct: 1844 WEVNLTNHCG----FMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPS-DSDDSLTKKL 1898 Query: 1616 RHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTS 1675 RHLGND V IV+++ D++ G I +F V +++ P+ + + + ++ Sbjct: 1899 RHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLF 1958 Query: 1676 VAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEA 1735 IV+ + LP + R A++A+ A + + +Y + + R R+++ + Q E Sbjct: 1959 DGAIVNGKVLPIMVRATAINASRALK------SLIPLYQNFYEERARYLQTIVQHHLEPT 2012 Query: 1736 AYSNPSLPLVHPPSHSKAPA 1755 + + + + P + P+ Sbjct: 2013 TFEDFAAQVFSPAPYHHLPS 2032 >gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapiens] Length = 663 Score = 73.2 bits (178), Expect = 2e-12 Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%) Query: 1494 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1553 P+L P S R + D+ + K V+Y GQ++ E +NE S + EFL Sbjct: 171 PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 225 Query: 1554 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1611 LG+ ++L+D K + GGLDV G+ G + YC + + +FH++T +P + D + Sbjct: 226 FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 281 Query: 1612 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1650 +KRH+GND V++V+ D F I F +V+V Sbjct: 282 LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 320 >gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapiens] Length = 727 Score = 73.2 bits (178), Expect = 2e-12 Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%) Query: 1494 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1553 P+L P S R + D+ + K V+Y GQ++ E +NE S + EFL Sbjct: 235 PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 289 Query: 1554 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1611 LG+ ++L+D K + GGLDV G+ G + YC + + +FH++T +P + D + Sbjct: 290 FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 345 Query: 1612 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1650 +KRH+GND V++V+ D F I F +V+V Sbjct: 346 LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 384 >gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapiens] Length = 681 Score = 73.2 bits (178), Expect = 2e-12 Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%) Query: 1494 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1553 P+L P S R + D+ + K V+Y GQ++ E +NE S + EFL Sbjct: 171 PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 225 Query: 1554 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1611 LG+ ++L+D K + GGLDV G+ G + YC + + +FH++T +P + D + Sbjct: 226 FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 281 Query: 1612 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1650 +KRH+GND V++V+ D F I F +V+V Sbjct: 282 LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 320 >gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform 2 [Homo sapiens] Length = 715 Score = 67.8 bits (164), Expect = 9e-11 Identities = 53/165 (32%), Positives = 77/165 (46%), Gaps = 23/165 (13%) Query: 1494 PILLPNESQSFERSVQLLDQIPSYDTH------KIAVLYVGEGQSNSELAILSNEHGSYR 1547 P+L P SQ I SYD H K V+Y Q+ E + N S Sbjct: 223 PVLYPKASQ----------MIVSYDEHEVNNTFKFGVIYQKARQTLEE-ELFGNNEESPA 271 Query: 1548 YTEFLTGLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTK 1605 + EFL LG I L+D K + GGLDV G+ G + Y D + +FH++T +P Sbjct: 272 FKEFLDLLGDTITLQDF---KGFRGGLDVTHGQTGVESVYTTFRD-REIMFHVSTKLPFT 327 Query: 1606 DVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1650 D D + +KRH+GND V+I++ + F I F +++V Sbjct: 328 DGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVV 372 >gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform 1 [Homo sapiens] Length = 730 Score = 67.8 bits (164), Expect = 9e-11 Identities = 53/165 (32%), Positives = 77/165 (46%), Gaps = 23/165 (13%) Query: 1494 PILLPNESQSFERSVQLLDQIPSYDTH------KIAVLYVGEGQSNSELAILSNEHGSYR 1547 P+L P SQ I SYD H K V+Y Q+ E + N S Sbjct: 238 PVLYPKASQ----------MIVSYDEHEVNNTFKFGVIYQKARQTLEE-ELFGNNEESPA 286 Query: 1548 YTEFLTGLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTK 1605 + EFL LG I L+D K + GGLDV G+ G + Y D + +FH++T +P Sbjct: 287 FKEFLDLLGDTITLQDF---KGFRGGLDVTHGQTGVESVYTTFRD-REIMFHVSTKLPFT 342 Query: 1606 DVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1650 D D + +KRH+GND V+I++ + F I F +++V Sbjct: 343 DGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVV 387 >gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sapiens] Length = 1013 Score = 66.6 bits (161), Expect = 2e-10 Identities = 47/153 (30%), Positives = 76/153 (49%), Gaps = 14/153 (9%) Query: 1505 ERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDC 1564 ++ + +L++ K VL+ +GQ + + SNE GS + +FL LG I LK Sbjct: 188 QKDLLVLEEQEGSVNFKFGVLFAKDGQLTDD-EMFSNEIGSEPFQKFLNLLGDTITLKGW 246 Query: 1565 QPDKVYLGGLDV----CGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1620 Y GGLD G +T +IM FH++T++P +K + ++KRH+GN Sbjct: 247 TG---YRGGLDTKNDTTGIHSVYTVYQGHEIM---FHVSTMLPYSKENKQQVERKRHIGN 300 Query: 1621 DFVSIVYNDSGED---FKLGTIKGQFNFVHVIV 1650 D V+IV+ + E FK I+ F + +V Sbjct: 301 DIVTIVFQEGEESSPAFKPSMIRSHFTHIFALV 333 >gi|112421013 signal-induced proliferation-associated 1 like 2 [Homo sapiens] Length = 1722 Score = 66.6 bits (161), Expect = 2e-10 Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%) Query: 1499 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1558 N + E+ ++L +Q S+ HKI +LY GQS E + +NE + EFL LG+ Sbjct: 587 NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644 Query: 1559 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1617 + LK + L D G +T ++M FH++TL+P ++ + +KRH Sbjct: 645 VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701 Query: 1618 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1650 +GND V+IV+ + G F +I+ F V VIV Sbjct: 702 IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735 >gi|206725526 signal-induced proliferation-associated protein 1 [Homo sapiens] Length = 1042 Score = 64.7 bits (156), Expect = 8e-10 Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%) Query: 1497 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1556 L + S R++ LD+ K+ +LY GQ + E + +N+ + +FLT LG Sbjct: 310 LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368 Query: 1557 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1615 ++ LK + + L D G +T +IM FH++T++P ++ + +K Sbjct: 369 DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425 Query: 1616 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1650 RH+GND V+IV+ + G + F TI+ F V ++V Sbjct: 426 RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461 >gi|206725523 signal-induced proliferation-associated protein 1 [Homo sapiens] Length = 1042 Score = 64.7 bits (156), Expect = 8e-10 Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%) Query: 1497 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1556 L + S R++ LD+ K+ +LY GQ + E + +N+ + +FLT LG Sbjct: 310 LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368 Query: 1557 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1615 ++ LK + + L D G +T +IM FH++T++P ++ + +K Sbjct: 369 DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425 Query: 1616 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1650 RH+GND V+IV+ + G + F TI+ F V ++V Sbjct: 426 RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461 >gi|7662126 signal-induced proliferation-associated 1 like 1 [Homo sapiens] Length = 1804 Score = 64.7 bits (156), Expect = 8e-10 Identities = 48/154 (31%), Positives = 78/154 (50%), Gaps = 7/154 (4%) Query: 1499 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1558 N + E+ ++L +Q +Y K+ ++Y GQS E + +NE + EFL LG Sbjct: 591 NTPKVTEQLMKLDEQGLNYQ-QKVGIMYCKAGQSTEE-EMYNNESAGPAFEEFLQLLGER 648 Query: 1559 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1617 + LK + + L D G +T +IM FH++T++P +K + +KRH Sbjct: 649 VRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIM---FHVSTMLPYTPNNKQQLLRKRH 705 Query: 1618 LGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1650 +GND V+IV+ + G + F I+ F V VIV Sbjct: 706 IGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIV 739 >gi|71143119 signal-induced proliferation-associated 1 like 3 [Homo sapiens] Length = 1781 Score = 63.2 bits (152), Expect = 2e-09 Identities = 44/136 (32%), Positives = 69/136 (50%), Gaps = 12/136 (8%) Query: 1520 HKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDV--- 1576 HK+ +LY GQS+ E + +NE + EFL+ +G + LK Y LDV Sbjct: 623 HKVGILYCKAGQSSEE-EMYNNEEAGPAFEEFLSLIGEKVCLKGFTK---YAAQLDVKTD 678 Query: 1577 -CGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGE-DF 1634 G +T +IM FH++TL+P ++ + +KRH+GND V+I++ + G F Sbjct: 679 STGTHSLYTMYQDYEIM---FHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPF 735 Query: 1635 KLGTIKGQFNFVHVIV 1650 I+ F V +IV Sbjct: 736 TPKNIRSHFQHVFIIV 751 >gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] Length = 991 Score = 42.4 bits (98), Expect = 0.004 Identities = 52/229 (22%), Positives = 86/229 (37%), Gaps = 35/229 (15%) Query: 1090 SGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQF 1149 S P SSS+P ++ G + G R R++ S V +P Sbjct: 236 SSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETS------VAPFALPTVSL 289 Query: 1150 LGSATS--PGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVP---------LLTQGWAEIL 1198 L + T P P A + + + G R P+ + ++P L IL Sbjct: 290 LPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPIL 349 Query: 1199 VRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE---HRDTALYKSLSV 1255 + P+G+ + L+++ + +P + +LM ER H + +S + Sbjct: 350 LLDPSGSHAPLLTVPG--------LGPLPFH-FAQSLMTTERLSGSGLHWPLSRTRSEPL 400 Query: 1256 PAASTAKPPPLPRS------NTDSAVVMEEGSPGEVPVLVEPPGLEDVE 1298 P ++TA PPP P T V+ P E P L + P ED+E Sbjct: 401 PPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLE 449 >gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens] Length = 1243 Score = 41.6 bits (96), Expect = 0.007 Identities = 67/283 (23%), Positives = 98/283 (34%), Gaps = 27/283 (9%) Query: 1150 LGSATSPGPRTAPAAKPEKASAGT-RVPVQEKTNLAAYVPLLTQGWAEILVRRPT--GNT 1206 + S S P P + P S+ T PV PL W+ + P T Sbjct: 846 ISSQVSSNPSPHPTSSPLPFSSSTPEFPV----------PLSQCPWSSLPTTSPPTFSPT 895 Query: 1207 SWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPL 1266 ++L +P P ++ P + L A F T LS ++ PP Sbjct: 896 CSQVTLSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPA 955 Query: 1267 PRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHA 1326 P S S + +PG + EA+ R +R + +S + + Sbjct: 956 PPSPLPSLPLPPPVAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGK----- 1010 Query: 1327 EELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGR 1386 +LVGR +V SS+ P+ L QP+ P S P L D D A G Sbjct: 1011 PQLVGR----FQVTSSK--EPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGP 1064 Query: 1387 LSPEVKARSQSGTLDGESAAWSASGEDSRGQPEG--PLPSSSP 1427 + E A S +G A G+D + G P P S P Sbjct: 1065 ETREALAESDRAA-EGLGAGVEEEGDDGKEPQVGGSPQPLSHP 1106 >gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens] Length = 1796 Score = 40.8 bits (94), Expect = 0.012 Identities = 34/127 (26%), Positives = 52/127 (40%), Gaps = 8/127 (6%) Query: 1343 EGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPE-VKARSQSGTLD 1401 +G R + L P + S +Q + + G+ G+K D G P+ + S D Sbjct: 1488 DGPRGEIGLPGPQGPPGPQGPSGLSIQGMPGMPGEKGEKGDTGLPGPQGIPGGVGSPGRD 1547 Query: 1402 GESAAWSASGED-SRGQPEGPLPSSSPRSP------SGLRPRGYTISDSAPSRRGKRVER 1454 G G+D S G P P P P +P + P+G P +G+R ER Sbjct: 1548 GSPGQRGLPGKDGSSGPPGPPGPIGIPGTPGVPGITGSMGPQGALGPPGVPGAKGERGER 1607 Query: 1455 DALKSRA 1461 L+S+A Sbjct: 1608 GDLQSQA 1614 >gi|145199237 transcription elongation factor B polypeptide 3 binding protein 1 [Homo sapiens] Length = 1221 Score = 40.8 bits (94), Expect = 0.012 Identities = 93/419 (22%), Positives = 143/419 (34%), Gaps = 68/419 (16%) Query: 1097 SPGVHVRQTKEA-----PAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALD-VPASQFL 1150 SPG H + +A P ++ G + S + DR + GG G GAL+ VP + Sbjct: 152 SPGSHGLLSPDAGYQPTPLAAPAEPGSKYSLASLDRGQGRGGGGG---GALEYVPKA--- 205 Query: 1151 GSATSPGPRTAPAAKPEKASAGTRVPVQEK----TNLAAYVPLLTQGWAEILVRRPTGNT 1206 + P + P + +R P + +N +A E +RP G+ Sbjct: 206 --VSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSR 263 Query: 1207 SWLMSLENPLSPFSSDINNMPLQELSNALMAAE-RFKEHRDTALYKSLSVPAASTAKPPP 1265 P +P ++L + + + RF + D A + P ++ Sbjct: 264 G-----SEPYTPAP--------KKLCDPFGSCDARFSDSEDEAATVPGNEPTTAST---- 306 Query: 1266 LPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLH 1325 P++ D E+ +PP E +EA G R T + V + Sbjct: 307 -PKARADP----------EIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAK 355 Query: 1326 AEELVGRGIPIERVVSSEGG-----RPSVDLSFQPSQPLSKSSSSPELQTLQDILGDP-- 1378 P + S +GG +P + P P K + + +T G P Sbjct: 356 PAS------PAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVE 409 Query: 1379 ---GDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRP 1435 DK SP KA GT S+A + +G+P+ P SP S RP Sbjct: 410 KPRADKKGPQASSPRRKAERPEGTKKKPSSATPVA-TSGKGRPDRPARRPSPTSGDS-RP 467 Query: 1436 ---RGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDES 1491 RG P R+ + L R S E P L H+ FGDES Sbjct: 468 AAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDES 526 >gi|95147555 microtubule-associated protein 1A [Homo sapiens] Length = 2803 Score = 40.0 bits (92), Expect = 0.020 Identities = 89/356 (25%), Positives = 130/356 (36%), Gaps = 55/356 (15%) Query: 1141 ALDVPASQFLGSATSPGPRTAPA-AKPEKASAGTRVPVQEKT-NLAAYVPLLTQGWAEIL 1198 +LD PAS F S+ P P P+ A+P A G+ ++ LA P T+ + Sbjct: 2160 SLDFPASAFGFSSLQPAPPQLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLE 2219 Query: 1199 VRRPTGNTSWLMSLENPLSPFSSDINNMP------LQELSNA-------LMAAERFKEHR 1245 V + S L L +P SP + ++N+P L E S++ AERF Sbjct: 2220 VTKAPSLDSSLPQLPSPSSPGAPLLSNLPRPASPALSEGSSSEATTPVISSVAERFSPSL 2279 Query: 1246 DTALYKSLSV-----PAAST----AKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLED 1296 + A +S + PAA + P P ++ D A+ PG++ + P LE Sbjct: 2280 EAAEQESGELDPGMEPAAHSLWDLTPLSPAPPASLDLALAPAPSLPGDMGDGILPCHLEC 2339 Query: 1297 VEAALGMDRRTDAYSRSSSVSSQEEKS--------LHAEELVGRGIPI-ERVVSSEGGRP 1347 EAA S + + E S AE P ER EG Sbjct: 2340 SEAATEKPSPFQVPSEDCAANGPTETSPNPPGPAPAKAENEEAAACPAWERGAWPEGAER 2399 Query: 1348 S--VDLSFQPSQPL--------SKSSSSPELQT-LQDILGDPGDKADVGRLSPEVKARSQ 1396 S D P QP+ SS+SPE++ Q +P + G LSP Sbjct: 2400 SSRPDTLLSPEQPVCPAGGSGGPPSSASPEVEAGPQGCATEP--RPHRGELSPSFLNPPL 2457 Query: 1397 SGTLDGESAAWS---ASGEDSR------GQPEGPLPSSSPRSPSGLRPRGYTISDS 1443 ++D + G R G GP P + P+ G + SDS Sbjct: 2458 PPSIDDRDLSTEEVRLVGRGGRRRVGGPGTTGGPCPVTDETPPTSASDSGSSQSDS 2513 >gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo sapiens] Length = 1268 Score = 39.7 bits (91), Expect = 0.026 Identities = 61/244 (25%), Positives = 88/244 (36%), Gaps = 19/244 (7%) Query: 996 TSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGG 1055 +S L S +N + SL + T T D ++ V N PK SPV +L+G Sbjct: 263 SSPGLPSTQDNLIRNHTGSLAVANNNPTITVADSLSCPVMQNVQP-PKSSPVVSTVLSGS 321 Query: 1056 R----TKTWLVGNKLVTVTTSVGTGTRSLL--GLDSGELQSGPESSSSPGVHVRQTKEAP 1109 T+T N V TSV + L G+ GE + SS+ + E Sbjct: 322 SGSSSTRTPPTANHPVEPVTSVTQPSELLQQKGVQYGEYVNNQASSAPTPLSSTSDDEEE 381 Query: 1110 AKLESQAGQQVSRGARDRVRSMSGGHGLRVGAL-DVPASQFLGSATSPGPRTAPAAKPEK 1168 + + +AG S + L G+ D+ +S A P P PA+ P Sbjct: 382 EEEDEEAGVDSSSTTSSASPMPNSYDALEGGSYPDMLSSSASSPAPDPAPEPDPASAPAP 441 Query: 1169 ASAGTRVPVQEKTNLAAY---VPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINN 1225 ASA V Q + P L G+ T+ L+S P +P S Sbjct: 442 ASAPAPVVPQPSKMAKPFGYGYPTLQPGYQNA--------TAPLISGVQPSNPVYSGFQQ 493 Query: 1226 MPLQ 1229 P Q Sbjct: 494 YPQQ 497 >gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] Length = 2752 Score = 39.7 bits (91), Expect = 0.026 Identities = 50/171 (29%), Positives = 64/171 (37%), Gaps = 26/171 (15%) Query: 1312 RSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTL 1371 RS S SS + K+ L R S G P VD + S S+S SSPE++ Sbjct: 1556 RSESDSSPDSKAKTRTPLRQR--------SRSGSSPEVDSKSRLSPRRSRSGSSPEVKDK 1607 Query: 1372 QDIL--------GDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLP 1423 P KA R P S G S S+S E S PE P Sbjct: 1608 PRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESS---PEHPPK 1664 Query: 1424 SSSPRSPSGLRPRGYTISDSAPSRRGKRVE-------RDALKSRATASNAE 1467 S + R S P T S + P RR R R + +SR+ +S+ E Sbjct: 1665 SRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPE 1715 Score = 38.5 bits (88), Expect = 0.059 Identities = 57/208 (27%), Positives = 88/208 (42%), Gaps = 28/208 (13%) Query: 1277 MEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPI 1336 M G EV + P L +E +D + + +RSS SS E L + + G+ Sbjct: 1343 MNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQS-TRSSGHSSSE---LSPDAVEKAGMSS 1398 Query: 1337 ERVVSSEGGRPSVD-LSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARS 1395 + +SS P +D + PS+ S S+SSPE++ G P + R R Sbjct: 1399 NQSISS----PVLDAVPRTPSRERSSSASSPEMKD-----GLPRTPSRRSRSGSSPGLRD 1449 Query: 1396 QSGTLDGESAAWSASG------EDSRGQPE---GPLPSSSPRSPSGLRPRGYTISDSAPS 1446 SGT S + S+ G SRG+ E P P + P++P RPR + S S+P Sbjct: 1450 GSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTP---RPR--SRSPSSPE 1504 Query: 1447 RRGKRVERDALKSRATASNAEKVPGINP 1474 K + +S + +S +K P Sbjct: 1505 LNNKCLTPQRERSGSESSVDQKTVARTP 1532 Score = 36.6 bits (83), Expect = 0.22 Identities = 117/525 (22%), Positives = 181/525 (34%), Gaps = 61/525 (11%) Query: 981 SVSEHVVRSRIQTSLTSASLGSA-DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFT 1039 SV E+ +SRI +LT+ SLG+A S++ A + + + + + + + Sbjct: 2171 SVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLAS 2230 Query: 1040 AVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSG-----PES 1094 +P S LA RT L T +L + S P + Sbjct: 2231 RIPAASAAA-MNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRT 2289 Query: 1095 SSSPGVHVRQTKEAPAKLE--SQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGS 1152 ++P V++ + PA L S G A + S L P S Sbjct: 2290 PTAPAVNLAGAR-TPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRS---AH 2345 Query: 1153 ATSP----GPRTAPAAKPEKASAGTRVPVQEKTNL-------AAYVPLLTQGWAEILVRR 1201 AT+P G RTA A P ++ P NL +AY + + +L R Sbjct: 2346 ATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRA 2405 Query: 1202 -----PTGNTSWLMSLENPLSPFSSDINNMPLQEL------------SNALMAAERFKEH 1244 P+ + M+ E SP SS + P Q L +A R Sbjct: 2406 RSRTPPSAPSQSRMTSERAPSP-SSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIA 2464 Query: 1245 RDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSP----GEVPVLV---EPPGLEDV 1297 + T + S S+ + + A + V G P GE P +P L + Sbjct: 2465 QTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAAL 2524 Query: 1298 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1357 + A +RR+ + S SSS SS S + + SS +P V L PS Sbjct: 2525 QPA--KERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSP 2582 Query: 1358 PLSKSSSSPELQTLQDILGDPGDK--ADVGRLSPEVKARSQSGTLDGESAAWSASGEDSR 1415 + + E G P + A R S + S S + S++ S+S S Sbjct: 2583 TPAPKEAVRE--------GRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2634 Query: 1416 GQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSR 1460 SSS SPS +P + A ++ ER + R Sbjct: 2635 SSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPR 2679 Score = 33.1 bits (74), Expect = 2.5 Identities = 108/468 (23%), Positives = 160/468 (34%), Gaps = 50/468 (10%) Query: 1091 GPESSSSPGVHVRQTKEAPAKLESQAGQQV-SRGARDRVRSMSGGHG-----LRVGALDV 1144 G S +P R PA+ ++ + +R R R R+ G +R G Sbjct: 656 GRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHS 715 Query: 1145 PASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTG 1204 Q G + S R + ++ S P +K+ +++ + P Sbjct: 716 RTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSR--------RSRSLSSPRS 767 Query: 1205 NTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVP--AASTAK 1262 +SL LS S P Q+ R + KS + P + S++ Sbjct: 768 KAKSRLSLRRSLSGSSP----CPKQKSQTP---PRRSRSGSSQPKAKSRTPPRRSRSSSS 820 Query: 1263 PPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSS--QE 1320 PPP +S T S SP PP + + ++ RS SS E Sbjct: 821 PPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPE 880 Query: 1321 EKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD 1380 KS G RV SS R S S P QP K+ SP Q P Sbjct: 881 LKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSP-QPKVKAIISPR-QRSHSGSSSPSP 938 Query: 1381 KADVGRLSPEVKARSQSGTLDGES---AAWSASGE---DSRGQPEGPLPSSSPRSPSGLR 1434 R +P ++RS S + ES +S SG D++ +PE P P S Sbjct: 939 SRVTSRTTPR-RSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETP-PRQSHSGSISPY 996 Query: 1435 PRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKP 1494 P+ + PS G + KS+ S + PG S G +S+ P Sbjct: 997 PKVKAQTPPGPSLSGSKSPCPQEKSK--DSLVQSCPG----------SLSLCAGVKSSTP 1044 Query: 1495 ILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNE 1542 P ES S+QL Q + H+ QS+SE L ++ Sbjct: 1045 ---PGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSK 1089 >gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] Length = 2968 Score = 39.3 bits (90), Expect = 0.035 Identities = 80/344 (23%), Positives = 118/344 (34%), Gaps = 55/344 (15%) Query: 1145 PASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTG 1204 PA AT P P+ A AA+ E + G R P +E AE+LV+ Sbjct: 2424 PAPLITMPATRPKPKKARAAE-ESGAKGPRRPGEE---------------AELLVK---- 2463 Query: 1205 NTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPP 1264 + E SP S L + K Y PAA +++P Sbjct: 2464 -----LDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYP----PAAGSSEPK 2514 Query: 1265 -PLPRSNTDSAVVMEEG------------SPGEVPVLVEPPGLEDVEAALGMDRRTDAYS 1311 P P++ TD + E G SP + E G E+ E++ + + S Sbjct: 2515 APWPKA-TDGDLAQEPGPGLTFEDSGNPKSPDKAQA--EQDGAEESESSSSSSSGSSSSS 2571 Query: 1312 RSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTL 1371 SSS S E + + G G GGR S + + P S SSSS + Sbjct: 2572 SSSSSSGSETEGEEEGDKNGDG------GCGTGGRNCSAASSRAASPASSSSSSSSSSSS 2625 Query: 1372 QDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPS 1431 + S + S S + S++ S+S S S S + Sbjct: 2626 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEA 2685 Query: 1432 GLRPRGYTISDSAPSRRGKRVERDALKSRATA-SNAEKVPGINP 1474 P T SA + + + A K+R +A S +K P P Sbjct: 2686 APAP---TAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQP 2726 >gi|223718207 ets variant gene 3 isoform 1 [Homo sapiens] Length = 512 Score = 38.9 bits (89), Expect = 0.045 Identities = 87/357 (24%), Positives = 123/357 (34%), Gaps = 73/357 (20%) Query: 1090 SGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMS----GGHGLRVGALDVP 1145 SG ESS+ K ++LE + RG D V S + GG G + D+ Sbjct: 177 SGQESSNGT-----DRKTELSELEDGSAADWRRGV-DPVSSRNAIGGGGIGHQKRKPDIM 230 Query: 1146 ASQFLGSATSPGPRTAPAAKPEKASAGT-RVPVQEKTNLAAYVPLLTQGWAEILVRRPTG 1204 F P P + A P G VP+ +L Sbjct: 231 LPLFARPGMYPDPHSPFAVSPIPGRGGVLNVPISPALSLTP------------------- 271 Query: 1205 NTSWLMSLENPLSPF-SSDINNMPLQELSNAL--MAAERFKEH---RDTALYKSLSVPAA 1258 T + S LSPF SS + +E+ + L A F H R Y L VP Sbjct: 272 -TIFSYSPSPGLSPFTSSSCFSFNPEEMKHYLHSQACSVFNYHLSPRTFPRYPGLMVPPL 330 Query: 1259 STA-------------KPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDR 1305 +PPP+ R N + EE +P P + P VE A D Sbjct: 331 QCQMHPEESTQFSIKLQPPPVGRKNRERVESSEESAPVTTPTMASIPPRIKVEPASEKD- 389 Query: 1306 RTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGG----RPSVDLSFQPSQPLSK 1361 S S EK H +E G R + E G RP+ PS P+S Sbjct: 390 ------PESLRQSAREKEEHTQE---EGTVPSRTIEEEKGTIFARPAAP-PIWPSVPIST 439 Query: 1362 SSSSPELQTLQDILGDPG------DKADVGRLSPEVKARSQSGTLDGESAAWSASGE 1412 S P L+ +D PG +K + + P+++ + + D E+ S SG+ Sbjct: 440 PSGEP-LEVTEDSEDRPGKEPSAPEKKEDALMPPKLRLKRRWND-DPEARELSKSGK 494 >gi|33620755 YEATS domain containing 2 [Homo sapiens] Length = 1422 Score = 38.9 bits (89), Expect = 0.045 Identities = 42/170 (24%), Positives = 68/170 (40%), Gaps = 22/170 (12%) Query: 1218 PFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVM 1277 P +S +P ++ N + F+ T K +S ST P PLPR+ T + V + Sbjct: 429 PIASSCKIVPQSQVPNPESPGKSFQPI--TMSCKIVSGSPISTPSPSPLPRTPTSTPVHV 486 Query: 1278 EEGSPGEV-----PVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGR 1332 ++G+ G V ++ + PG T+ S +S VS G Sbjct: 487 KQGTAGSVINNPYVIMDKQPGQVIGATTPSTGSPTNKISTASQVSQ------------GT 534 Query: 1333 GIPIERVVSSEGGRPSV---DLSFQPSQPLSKSSSSPELQTLQDILGDPG 1379 G P+ ++ S +V D F PL S P++Q+ + I G G Sbjct: 535 GSPVPKIHGSSFVTSTVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGLG 584 >gi|163965366 nascent polypeptide-associated complex alpha subunit isoform a [Homo sapiens] Length = 2078 Score = 38.9 bits (89), Expect = 0.045 Identities = 75/340 (22%), Positives = 115/340 (33%), Gaps = 31/340 (9%) Query: 1151 GSATSPGPR---TAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTS 1207 G T+P + T PAA P P K A P ++ P + Sbjct: 1358 GGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPA 1417 Query: 1208 WLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLP 1267 ++ E +P D+ + +S L A + S A PP P Sbjct: 1418 TPVTREGAATPSKGDLTPPAVTPVS--LKKAPATSAPKGGPATPSSKGDPTLPAVTPPSP 1475 Query: 1268 RSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEA----------ALGMDRRTDAYSRSSSVS 1317 + V SP + P P G + A A RR ++ +S Sbjct: 1476 KEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLS 1535 Query: 1318 SQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQ-PSQPLSKSSSSPELQTLQDILG 1376 + +L +E + IP V S P++ + P+ P SK +SSP T G Sbjct: 1536 KKTPATLAPKEAL---IPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKG 1592 Query: 1377 DPGDK---ADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGP--LPSS---SPR 1428 P K SP K + S + +G P P PSS SP Sbjct: 1593 APSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPT 1652 Query: 1429 SPSGLRPR-GYTI---SDSAPSRRGKRVERDALKSRATAS 1464 SP+ + + G T+ S P+++G ++ L + A S Sbjct: 1653 SPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPES 1692 Score = 32.0 bits (71), Expect = 5.5 Identities = 71/349 (20%), Positives = 126/349 (36%), Gaps = 36/349 (10%) Query: 1089 QSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQ 1148 + GP + SS G P+ E A +QV+ + + + +GA +PA Sbjct: 1453 KGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAP---MGAPTLPA-- 1507 Query: 1149 FLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSW 1208 + S+ P T + + A T + + LA L+ + V P + Sbjct: 1508 VIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPA---MTVPSPKKTPAI 1564 Query: 1209 LMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPL-- 1266 E P +P S + ++ P S A ++ + +++ P+ A PP Sbjct: 1565 PTPKEAPATPSSKEASSPPAVTPSTYKGAPSP----KELLIPPAVTSPSPKEAPTPPAVT 1620 Query: 1267 -PRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLH 1325 P A +G+P PV P L+D + + + Q K L Sbjct: 1621 PPSPEKGPATPAPKGTPTSPPVT--PSSLKDSPTS-----PASVTCKMGATVPQASKGLP 1673 Query: 1326 AEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ--PLSKSSSSPELQTLQDILGDPGDKAD 1383 A+ +G + V S + P++ P +K SS+ D G K Sbjct: 1674 AK----KGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGP 1729 Query: 1384 VGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPL--PSSSPRSP 1430 + ++P Q + ++ +A G+D+ P+GPL P S +P Sbjct: 1730 LSTVAPAPLLPVQ------KDSSKTAKGKDASHSPKGPLAPPESKASTP 1772 >gi|157738619 smoothelin-like 1 [Homo sapiens] Length = 512 Score = 38.9 bits (89), Expect = 0.045 Identities = 84/376 (22%), Positives = 129/376 (34%), Gaps = 45/376 (11%) Query: 1091 GPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFL 1150 G S R+ E S+ G VS A + MSGG GA Sbjct: 4 GAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNP--EMSGG-----GAPAEETKGTA 56 Query: 1151 GSATSPGPRTAPAAKPEKASA--GTRVPVQEKTNLAAYVPLLTQGWA------EILVRRP 1202 G A + GP T + K EKA A G +Q + N V + +Q A E +++ Sbjct: 57 GKAINEGPPTE-SGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKE 115 Query: 1203 TGNTSWLMSLENPLSPFSSDINNMPLQ-ELSNALMAAERFK-EHRDTALYKSLSVPAAST 1260 G ++ + + P + E + +A+E+ K E ++ A Sbjct: 116 DGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDR 175 Query: 1261 AKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE 1320 KP P + A + G+ P ++ TD +++ S + Sbjct: 176 DKPEPKATVEEEDAKTASQEETGQRKECSTEP----------KEKATDEEAKAESQKAVV 225 Query: 1321 EKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD 1380 E AE G + + G + D + SP + QD+ +P Sbjct: 226 EDEAKAEPKEPDG----KEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEG 281 Query: 1381 KADVGRLSPEVKARSQSG-----TLDGESAAWSASGEDSRGQPE---GPLPSSSPRSPSG 1432 A V SPE S +G + DG ASG+ S E +P S P SPS Sbjct: 282 GAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSS 341 Query: 1433 LRPRGYTISDSAPSRR 1448 + + AP RR Sbjct: 342 GEKK-----EKAPERR 352 >gi|110611914 progesterone receptor [Homo sapiens] Length = 933 Score = 38.1 bits (87), Expect = 0.077 Identities = 70/298 (23%), Positives = 107/298 (35%), Gaps = 44/298 (14%) Query: 1150 LGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWL 1209 LG A + G A A P A+ G + +E + +A L + A + R Sbjct: 244 LGGAAAGGG--AAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGR-------- 293 Query: 1210 MSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRS 1269 +PL+ D ++P+ L++AL+AA R ++ + Y + A++ A P P + Sbjct: 294 ----SPLATTVMDFIHVPILPLNHALLAA-RTRQLLEDESYDGGAGAASAFAPPRSSPCA 348 Query: 1270 NTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEEL 1329 ++ V G+ P PP E + DAY S K EE Sbjct: 349 SSTPVAV------GDFPDCAYPPDAEP---------KDDAYPLYSDFQPPALKIKEEEEG 393 Query: 1330 VGRGIPIERVVSSEGGRPSV--DLSFQPSQPLSKSSSSPELQTLQDILGDPGDKA-DVGR 1386 R G P+ D P PL ++ PG+ A Sbjct: 394 AEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSR----------PGEAAVTAAP 443 Query: 1387 LSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSA 1444 S V + S SG+ E + A G + P P P +P + L PR S SA Sbjct: 444 ASASVSSASSSGSTL-ECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSA 500 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.134 0.392 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 71,127,599 Number of Sequences: 37866 Number of extensions: 3473824 Number of successful extensions: 17642 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 25 Number of HSP's successfully gapped in prelim test: 210 Number of HSP's that attempted gapping in prelim test: 16844 Number of HSP's gapped (non-prelim): 1151 length of query: 1784 length of database: 18,247,518 effective HSP length: 117 effective length of query: 1667 effective length of database: 13,817,196 effective search space: 23033265732 effective search space used: 23033265732 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.