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Search of human proteins with 167234422
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo
sapiens]
(486 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s... 1000 0.0
gi|20357556 cortactin isoform b [Homo sapiens] 415 e-116
gi|20357552 cortactin isoform a [Homo sapiens] 396 e-110
gi|62198235 drebrin-like isoform b [Homo sapiens] 106 5e-23
gi|21361670 drebrin-like isoform a [Homo sapiens] 105 7e-23
gi|171906575 drebrin-like isoform c [Homo sapiens] 102 6e-22
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 69 1e-11
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 69 1e-11
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 69 1e-11
gi|109689723 abl interactor 2 [Homo sapiens] 68 2e-11
gi|148747351 protein kinase C and casein kinase substrate in neu... 63 5e-10
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 61 2e-09
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 61 2e-09
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 61 3e-09
gi|110349719 titin isoform N2-A [Homo sapiens] 60 3e-09
gi|27544941 myosin IF [Homo sapiens] 60 4e-09
gi|61743948 abl-interactor 1 isoform d [Homo sapiens] 60 6e-09
gi|61743944 abl-interactor 1 isoform b [Homo sapiens] 60 6e-09
gi|61743942 abl-interactor 1 isoform a [Homo sapiens] 60 6e-09
gi|61743946 abl-interactor 1 isoform c [Homo sapiens] 59 8e-09
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 58 2e-08
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 57 3e-08
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 57 5e-08
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 56 6e-08
gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens] 56 8e-08
gi|55956916 myosin IE [Homo sapiens] 56 8e-08
gi|24308229 protein kinase C and casein kinase substrate in neur... 55 1e-07
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 55 1e-07
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 55 1e-07
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 55 1e-07
>gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo
sapiens]
Length = 486
Score = 1000 bits (2586), Expect = 0.0
Identities = 486/486 (100%), Positives = 486/486 (100%)
Query: 1 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK 60
MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK
Sbjct: 1 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK 60
Query: 61 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF 120
VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF
Sbjct: 61 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF 120
Query: 121 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGE 180
GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGE
Sbjct: 121 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGE 180
Query: 181 TEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKA 240
TEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKA
Sbjct: 181 TEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKA 240
Query: 241 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS 300
KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS
Sbjct: 241 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS 300
Query: 301 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY 360
EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY
Sbjct: 301 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY 360
Query: 361 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA 420
EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA
Sbjct: 361 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA 420
Query: 421 GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN 480
GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN
Sbjct: 421 GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN 480
Query: 481 YVKLLE 486
YVKLLE
Sbjct: 481 YVKLLE 486
>gi|20357556 cortactin isoform b [Homo sapiens]
Length = 513
Score = 415 bits (1066), Expect = e-116
Identities = 233/547 (42%), Positives = 304/547 (55%), Gaps = 99/547 (18%)
Query: 1 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN 59
MWK+ GH VS++ + G DDW+TDPDFVND+SEKEQRWGAKT++GSG EHINIH+LR
Sbjct: 1 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 60
Query: 60 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG 119
V +EH L++KE+E+GPKASHGYGG+FGVE+DRMDKSAVGHEY +++ KH SQ D+ +G
Sbjct: 61 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 120
Query: 120 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG 179
FGGK+GV+ DR D+SAVGF+Y+G+ EKH SQKDYS GFGG+YGV+ D+ DK+A+G+DY+G
Sbjct: 121 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 180
Query: 180 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLK 239
+TEKHESQRDY+KGFGG+YGI KD+VDKSAVGF E + T ++ G G++
Sbjct: 181 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQGKTEKHESQKDYVKGFGGKFGVQ 239
Query: 240 AKFESMA------EEKRKREEEEK--------------------------AQQVARRQQ- 266
+ +EK + E +K QV+ Q
Sbjct: 240 TDRQDKCALGWDHQEKLQLHESQKDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQK 299
Query: 267 -----------------------ERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAW 303
E++ +R EA + +E +K+ +A
Sbjct: 300 TVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQAR 359
Query: 304 PPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAE 363
TPP S P E +P P+ + E P + E EPVY E
Sbjct: 360 AKTQTPPVS---PAPQPTEERLPSSPVYEDAASFKAELSYRGPVS----GTEPEPVYSME 412
Query: 364 PEPEPEPEPE------PENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSG 417
E + E YE E + ED +YE
Sbjct: 413 AADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYEN------------------ 454
Query: 418 CPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLF 477
LGI+AVALYDYQ G DE+SFDPDD+IT+IEM+D+GWWRG C G +GLF
Sbjct: 455 ----------DLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLF 504
Query: 478 PANYVKL 484
PANYV+L
Sbjct: 505 PANYVEL 511
>gi|20357552 cortactin isoform a [Homo sapiens]
Length = 550
Score = 396 bits (1017), Expect = e-110
Identities = 231/563 (41%), Positives = 310/563 (55%), Gaps = 94/563 (16%)
Query: 1 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN 59
MWK+ GH VS++ + G DDW+TDPDFVND+SEKEQRWGAKT++GSG EHINIH+LR
Sbjct: 1 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 60
Query: 60 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEV------------ 107
V +EH L++KE+E+GPKASHGYGG+FGVE+DRMDKSAVGHEY +++
Sbjct: 61 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 120
Query: 108 -------------------------EKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKG 142
EKH+SQ D + GFGGKYGV+ DR DKSAVGFDY+G
Sbjct: 121 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 180
Query: 143 EVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQK 202
+ EKH SQ+DYS+GFGG+YG++KDK DK+A+G++Y+G+TEKHESQ+DY KGFGG++G+Q
Sbjct: 181 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT 240
Query: 203 DRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKAKFESMA----EEKRKREEEEKA 258
DR DK A+G++ E ++ + G G++++ + A + K K + E
Sbjct: 241 DRQDKCALGWDHQE-KLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQ 299
Query: 259 QQVARR-------QQERKAVTKRSPEAPQPVIAMEEPAVPA-PLPKKISSEAWPPVGTPP 310
Q ++ Q++R + E V + + VP + K S+
Sbjct: 300 QDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAK 359
Query: 311 SSESEPVRTSR-EHPVPLLPIRQTLPE-----------DNEEPPALPPRTLEGLQVEEEP 358
E E R + E + RQ E + PP P ++ P
Sbjct: 360 EKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSP 419
Query: 359 VYEAEPE---------PEPEPEPEPENDYEDVEEMDRHEQED---EPEGDYEEVLEP--- 403
VYE P EPEP E + + Q+ E YE P
Sbjct: 420 VYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHY 479
Query: 404 --EDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMV 461
EDS++ LGI+AVALYDYQ G DE+SFDPDD+IT+IEM+
Sbjct: 480 PAEDSTYDEY--------------ENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMI 525
Query: 462 DEGWWRGRCHGHFGLFPANYVKL 484
D+GWWRG C G +GLFPANYV+L
Sbjct: 526 DDGWWRGVCKGRYGLFPANYVEL 548
>gi|62198235 drebrin-like isoform b [Homo sapiens]
Length = 430
Score = 106 bits (264), Expect = 5e-23
Identities = 103/343 (30%), Positives = 138/343 (40%), Gaps = 92/343 (26%)
Query: 191 AKGFGGQYGIQKDRVDKSAVGFNEMEAPT-TAYKKTTPI-EAASSGTRGLKAKFES---- 244
AK G Y K+ VG +AP + Y+KT + E G AK E
Sbjct: 133 AKASGANYSFHKESGRFQDVG---PQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEEN 189
Query: 245 -MAEEKRKREEEEKAQQVARRQQERKAVTKR-----------SP----EAPQPVI----- 283
EEKR+ EE ++ + RR++E + +R SP E Q V+
Sbjct: 190 RRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRN 249
Query: 284 -----------------AMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVP 326
AM ++ +P P K+ S T P + RE
Sbjct: 250 EQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHF-----GREPAAA 304
Query: 327 LLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEP--EPEPEPENDYEDVEEM 384
+ R LP + E P+ PP + Q EEE VYE PE E E P + E +
Sbjct: 305 ISRPRADLPAE-EPAPSTPPCLV---QAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI 360
Query: 385 DRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGS 444
D H Q G G G+ A ALYDYQ
Sbjct: 361 DHHIQ---------------------------------GQGLSGQGLCARALYDYQAADD 387
Query: 445 DELSFDPDDVITDIEMVDEGWWRG-RCHGHFGLFPANYVKLLE 486
E+SFDP+++IT IE++DEGWWRG GHFG+FPANYV+L+E
Sbjct: 388 TEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE 430
>gi|21361670 drebrin-like isoform a [Homo sapiens]
Length = 431
Score = 105 bits (263), Expect = 7e-23
Identities = 103/344 (29%), Positives = 138/344 (40%), Gaps = 93/344 (27%)
Query: 191 AKGFGGQYGIQKDRVDKSAVGFNEMEAPT-TAYKKTTPI-EAASSGTRGLKAKFES---- 244
AK G Y K+ VG +AP + Y+KT + E G AK E
Sbjct: 133 AKASGANYSFHKESGRFQDVG---PQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEEN 189
Query: 245 -MAEEKRKREEEEKAQQVARRQQERKAVTKR-----------SP-----EAPQPVI---- 283
EEKR+ EE ++ + RR++E + +R SP E Q V+
Sbjct: 190 RRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNR 249
Query: 284 ------------------AMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPV 325
AM ++ +P P K+ S T P + RE
Sbjct: 250 NEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHF-----GREPAA 304
Query: 326 PLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEP--EPEPEPENDYEDVEE 383
+ R LP + E P+ PP + Q EEE VYE PE E E P + E
Sbjct: 305 AISRPRADLPAE-EPAPSTPPCLV---QAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEH 360
Query: 384 MDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEG 443
+D H Q G G G+ A ALYDYQ
Sbjct: 361 IDHHIQ---------------------------------GQGLSGQGLCARALYDYQAAD 387
Query: 444 SDELSFDPDDVITDIEMVDEGWWRG-RCHGHFGLFPANYVKLLE 486
E+SFDP+++IT IE++DEGWWRG GHFG+FPANYV+L+E
Sbjct: 388 DTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE 431
>gi|171906575 drebrin-like isoform c [Homo sapiens]
Length = 439
Score = 102 bits (255), Expect = 6e-22
Identities = 105/350 (30%), Positives = 144/350 (41%), Gaps = 97/350 (27%)
Query: 191 AKGFGGQYGIQKDRVDKSAVGFNEMEAPT-TAYKKTTPI-EAASSGTRGLKAKFES---- 244
AK G Y K+ VG +AP + Y+KT + E G AK E
Sbjct: 133 AKASGANYSFHKESGRFQDVG---PQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEEN 189
Query: 245 -MAEEKRKREEEEKAQQVARRQQERKAVTKR-----------SP-----EAPQPVIAM-- 285
EEKR+ EE ++ + RR++E + +R SP E Q V++
Sbjct: 190 RRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNR 249
Query: 286 -EEPAVPAPL------PKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDN 338
E+ + A L P++I + + T S +P + P L + T PE +
Sbjct: 250 NEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRS----PFLQKQLTQPETH 305
Query: 339 ------------------EEP-PALPPRTLEGLQVEEEPVYEAEPEPEP--EPEPEPEND 377
EEP P+ PP + Q EEE VYE PE E E P +
Sbjct: 306 FGREPAAAISRPRADLPAEEPAPSTPPCLV---QAEEEAVYEEPPEQETFYEQPPLVQQQ 362
Query: 378 YEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALY 437
E +D H Q G G G+ A ALY
Sbjct: 363 GAGSEHIDHHIQ---------------------------------GQGLSGQGLCARALY 389
Query: 438 DYQGEGSDELSFDPDDVITDIEMVDEGWWRG-RCHGHFGLFPANYVKLLE 486
DYQ E+SFDP+++IT IE++DEGWWRG GHFG+FPANYV+L+E
Sbjct: 390 DYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE 439
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 68.6 bits (166), Expect = 1e-11
Identities = 33/71 (46%), Positives = 44/71 (61%), Gaps = 2/71 (2%)
Query: 418 CPAGAGA--GAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFG 475
CPA A + V G A ALYD++GE DELSF D+IT++E VD+ W G G G
Sbjct: 659 CPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSG 718
Query: 476 LFPANYVKLLE 486
+FP NY++ L+
Sbjct: 719 IFPKNYIQFLQ 729
Score = 61.2 bits (147), Expect = 2e-09
Identities = 49/208 (23%), Positives = 83/208 (39%), Gaps = 16/208 (7%)
Query: 291 PAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLE 350
P P+ K PP PP P ++ LP ++ + + + T
Sbjct: 289 PRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT-- 346
Query: 351 GLQVEEEPVYEAEPEPEPEPEPEPEND-YEDVEEMDRHEQEDEPEGDYEEVLEPEDSS-- 407
GL + V++ + +P P P+P + Y D + E +Y E + ED+
Sbjct: 347 GLSKAKSQVFKNQ-DPVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRV 405
Query: 408 ----------FSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITD 457
L P+ A + AV L+D+ E D+L+ +++
Sbjct: 406 HLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYL 465
Query: 458 IEMVDEGWWRGRCHGHFGLFPANYVKLL 485
+E +D W+RG C G+FPANYVK++
Sbjct: 466 LEKIDTDWYRGNCRNQIGIFPANYVKVI 493
Score = 51.6 bits (122), Expect = 2e-06
Identities = 25/57 (43%), Positives = 34/57 (59%)
Query: 430 GISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE 486
G VA ++Y GE DELSF ++I E V+E W RG G G+FP N+V+ +E
Sbjct: 514 GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVE 570
Score = 44.3 bits (103), Expect = 3e-04
Identities = 21/49 (42%), Positives = 29/49 (59%)
Query: 435 ALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVK 483
AL+ + E SD+LSF D I +E +D W RGR G+FPA +V+
Sbjct: 609 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 657
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 68.6 bits (166), Expect = 1e-11
Identities = 33/71 (46%), Positives = 44/71 (61%), Gaps = 2/71 (2%)
Query: 418 CPAGAGA--GAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFG 475
CPA A + V G A ALYD++GE DELSF D+IT++E VD+ W G G G
Sbjct: 695 CPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSG 754
Query: 476 LFPANYVKLLE 486
+FP NY++ L+
Sbjct: 755 IFPKNYIQFLQ 765
Score = 61.2 bits (147), Expect = 2e-09
Identities = 49/208 (23%), Positives = 83/208 (39%), Gaps = 16/208 (7%)
Query: 291 PAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLE 350
P P+ K PP PP P ++ LP ++ + + + T
Sbjct: 325 PRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT-- 382
Query: 351 GLQVEEEPVYEAEPEPEPEPEPEPEND-YEDVEEMDRHEQEDEPEGDYEEVLEPEDSS-- 407
GL + V++ + +P P P+P + Y D + E +Y E + ED+
Sbjct: 383 GLSKAKSQVFKNQ-DPVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRV 441
Query: 408 ----------FSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITD 457
L P+ A + AV L+D+ E D+L+ +++
Sbjct: 442 HLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYL 501
Query: 458 IEMVDEGWWRGRCHGHFGLFPANYVKLL 485
+E +D W+RG C G+FPANYVK++
Sbjct: 502 LEKIDTDWYRGNCRNQIGIFPANYVKVI 529
Score = 51.6 bits (122), Expect = 2e-06
Identities = 25/57 (43%), Positives = 34/57 (59%)
Query: 430 GISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE 486
G VA ++Y GE DELSF ++I E V+E W RG G G+FP N+V+ +E
Sbjct: 550 GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVE 606
Score = 44.3 bits (103), Expect = 3e-04
Identities = 21/49 (42%), Positives = 29/49 (59%)
Query: 435 ALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVK 483
AL+ + E SD+LSF D I +E +D W RGR G+FPA +V+
Sbjct: 645 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 693
Score = 30.4 bits (67), Expect = 3.8
Identities = 32/119 (26%), Positives = 46/119 (38%), Gaps = 13/119 (10%)
Query: 255 EEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLP-KKISSEAWPPVGTPPSSE 313
+E+A Q A RK R P P + E+P P PLP +K + V S+
Sbjct: 244 KERAVQPA---PTRKPTVIRIPAKPGKCLH-EDPQSPPPLPAEKPIGNTFSTVSGKLSNV 299
Query: 314 SEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQV-EEEPVYEAEPEPEPEPE 371
HP + PP LPPR + G + ++P + PE P P+
Sbjct: 300 ERTRNLESNHPGQTGGFVRV-------PPRLPPRPVNGKTIPTQQPPTKVPPERPPPPK 351
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 68.6 bits (166), Expect = 1e-11
Identities = 33/71 (46%), Positives = 44/71 (61%), Gaps = 2/71 (2%)
Query: 418 CPAGAGA--GAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFG 475
CPA A + V G A ALYD++GE DELSF D+IT++E VD+ W G G G
Sbjct: 718 CPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSG 777
Query: 476 LFPANYVKLLE 486
+FP NY++ L+
Sbjct: 778 IFPKNYIQFLQ 788
Score = 55.1 bits (131), Expect = 1e-07
Identities = 21/53 (39%), Positives = 34/53 (64%)
Query: 433 AVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLL 485
AV L+D+ E D+L+ +++ +E +D W+RG C G+FPANYVK++
Sbjct: 500 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI 552
Score = 51.6 bits (122), Expect = 2e-06
Identities = 25/57 (43%), Positives = 34/57 (59%)
Query: 430 GISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE 486
G VA ++Y GE DELSF ++I E V+E W RG G G+FP N+V+ +E
Sbjct: 573 GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVE 629
Score = 44.3 bits (103), Expect = 3e-04
Identities = 21/49 (42%), Positives = 29/49 (59%)
Query: 435 ALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVK 483
AL+ + E SD+LSF D I +E +D W RGR G+FPA +V+
Sbjct: 668 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 716
Score = 30.4 bits (67), Expect = 3.8
Identities = 32/119 (26%), Positives = 46/119 (38%), Gaps = 13/119 (10%)
Query: 255 EEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLP-KKISSEAWPPVGTPPSSE 313
+E+A Q A RK R P P + E+P P PLP +K + V S+
Sbjct: 244 KERAVQPA---PTRKPTVIRIPAKPGKCLH-EDPQSPPPLPAEKPIGNTFSTVSGKLSNV 299
Query: 314 SEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQV-EEEPVYEAEPEPEPEPE 371
HP + PP LPPR + G + ++P + PE P P+
Sbjct: 300 ERTRNLESNHPGQTGGFVRV-------PPRLPPRPVNGKTIPTQQPPTKVPPERPPPPK 351
>gi|109689723 abl interactor 2 [Homo sapiens]
Length = 475
Score = 68.2 bits (165), Expect = 2e-11
Identities = 48/159 (30%), Positives = 66/159 (41%), Gaps = 37/159 (23%)
Query: 325 VPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEM 384
+PL+ + E+ + P PP EEPV++ P P P PE E + VE
Sbjct: 347 LPLMGFVARVQENISDTPPPPPPV-------EEPVFDESPPPPPPPEDYEEEEAAVVEYS 399
Query: 385 DRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGS 444
D + +ED P LE VA+YDY +
Sbjct: 400 DPYAEEDPPWAP-RSYLE-----------------------------KVVAIYDYTKDKE 429
Query: 445 DELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVK 483
DELSF +I I+ D+GW+ G +G GLFP NYV+
Sbjct: 430 DELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVE 468
>gi|148747351 protein kinase C and casein kinase substrate in
neurons 2 [Homo sapiens]
Length = 486
Score = 63.2 bits (152), Expect = 5e-10
Identities = 46/154 (29%), Positives = 72/154 (46%), Gaps = 13/154 (8%)
Query: 343 ALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMD--------RHEQEDEPE 394
+LP + L V P A+ + P + ++ V E D +E+
Sbjct: 336 SLPSKPSSTLNVPSNPAQSAQSQSSYNPFEDEDDTGSTVSEKDDTKAKNVSSYEKTQSYP 395
Query: 395 GDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDV 454
D+ + + ++ FSS A P A + + ALYDY+G+ DELSF D
Sbjct: 396 TDWSD--DESNNPFSSTDANGDSNPFDDDATS-GTEVRVRALYDYEGQEHDELSFKAGDE 452
Query: 455 ITDIEMVDE-GWWRGRC-HGHFGLFPANYVKLLE 486
+T +E DE GW +GR +G GL+PANYV+ ++
Sbjct: 453 LTKMEDEDEQGWCKGRLDNGQVGLYPANYVEAIQ 486
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 61.2 bits (147), Expect = 2e-09
Identities = 56/204 (27%), Positives = 85/204 (41%), Gaps = 29/204 (14%)
Query: 295 PKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQV 354
P + E G P++ +E + E P P+ P+ D+ PA P+ L +
Sbjct: 782 PGWLGGELKGKTGWFPANYAEKI-PENEVPAPVKPVT-----DSTSAPA--PK----LAL 829
Query: 355 EEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDS-------- 406
E P A EP P N++ D ++PE D + + S
Sbjct: 830 RETPAPLAVTSSEPSTTP---NNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQ 886
Query: 407 -----SFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMV 461
+F+ A A S G G G+ A ALY ++ + + L+F+ +DVIT +E
Sbjct: 887 LRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQ 946
Query: 462 DEGWWRGRCHGHFGLFPANYVKLL 485
D WW G G G FP +YVKL+
Sbjct: 947 DM-WWFGEVQGQKGWFPKSYVKLI 969
Score = 59.7 bits (143), Expect = 6e-09
Identities = 24/59 (40%), Positives = 35/59 (59%)
Query: 426 AVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKL 484
A+A + +YDY + DEL+F+ +I + D WW+G +G GLFP+NYVKL
Sbjct: 1153 ALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKL 1211
Score = 48.1 bits (113), Expect = 2e-05
Identities = 42/180 (23%), Positives = 74/180 (41%), Gaps = 8/180 (4%)
Query: 311 SSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEP 370
S E+E ++ +E ++ + + E + LE +Q E+E + E +
Sbjct: 624 SMEAERLK-QKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKL 682
Query: 371 EPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALG 430
+ E +D EE + E +D+ + + EP + + + + P A
Sbjct: 683 KREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKV 742
Query: 431 ISAVALYDYQGEGSDELSFDPDDVI-TDIEMVDE------GWWRGRCHGHFGLFPANYVK 483
+ ALY ++ DE++ P D++ E VDE GW G G G FPANY +
Sbjct: 743 VYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
Score = 47.8 bits (112), Expect = 2e-05
Identities = 60/245 (24%), Positives = 91/245 (37%), Gaps = 41/245 (16%)
Query: 275 SPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSRE-----------H 323
S AP P +A+ E PAPL S + P S + P T+ +
Sbjct: 819 STSAPAPKLALRE--TPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQ 876
Query: 324 PVPLLPIRQTLPEDNEEPPALPPRT-----------LEGLQVEEEPVYEAEPEPEPEPEP 372
P +P L + + PA + +EGLQ + + A+ +
Sbjct: 877 PSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFN- 935
Query: 373 EPENDYEDVEEMDRHEQEDEPEGD-------YEEVLEPEDSSFSSALAGSSGCPAGA--- 422
+ND V E E +G Y +++ +S +GSS PA
Sbjct: 936 --KNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRV 993
Query: 423 ---GAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPA 479
A V G +A+Y Y+ +L+F DVI + D WW G G+FP+
Sbjct: 994 ASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVIL-VTKKDGDWWTGTVGDKAGVFPS 1052
Query: 480 NYVKL 484
NYV+L
Sbjct: 1053 NYVRL 1057
Score = 37.4 bits (85), Expect = 0.031
Identities = 20/58 (34%), Positives = 26/58 (44%), Gaps = 5/58 (8%)
Query: 433 AVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHG-----HFGLFPANYVKLL 485
A + Y G ++L+ P +I + GWW G G FPANYVKLL
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 61.2 bits (147), Expect = 2e-09
Identities = 56/204 (27%), Positives = 85/204 (41%), Gaps = 29/204 (14%)
Query: 295 PKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQV 354
P + E G P++ +E + E P P+ P+ D+ PA P+ L +
Sbjct: 782 PGWLGGELKGKTGWFPANYAEKI-PENEVPAPVKPVT-----DSTSAPA--PK----LAL 829
Query: 355 EEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDS-------- 406
E P A EP P N++ D ++PE D + + S
Sbjct: 830 RETPAPLAVTSSEPSTTP---NNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQ 886
Query: 407 -----SFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMV 461
+F+ A A S G G G+ A ALY ++ + + L+F+ +DVIT +E
Sbjct: 887 LRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQ 946
Query: 462 DEGWWRGRCHGHFGLFPANYVKLL 485
D WW G G G FP +YVKL+
Sbjct: 947 DM-WWFGEVQGQKGWFPKSYVKLI 969
Score = 59.7 bits (143), Expect = 6e-09
Identities = 24/59 (40%), Positives = 35/59 (59%)
Query: 426 AVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKL 484
A+A + +YDY + DEL+F+ +I + D WW+G +G GLFP+NYVKL
Sbjct: 1153 ALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKL 1211
Score = 48.1 bits (113), Expect = 2e-05
Identities = 42/180 (23%), Positives = 74/180 (41%), Gaps = 8/180 (4%)
Query: 311 SSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEP 370
S E+E ++ +E ++ + + E + LE +Q E+E + E +
Sbjct: 624 SMEAERLK-QKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKL 682
Query: 371 EPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALG 430
+ E +D EE + E +D+ + + EP + + + + P A
Sbjct: 683 KREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKV 742
Query: 431 ISAVALYDYQGEGSDELSFDPDDVI-TDIEMVDE------GWWRGRCHGHFGLFPANYVK 483
+ ALY ++ DE++ P D++ E VDE GW G G G FPANY +
Sbjct: 743 VYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
Score = 47.8 bits (112), Expect = 2e-05
Identities = 60/245 (24%), Positives = 91/245 (37%), Gaps = 41/245 (16%)
Query: 275 SPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSRE-----------H 323
S AP P +A+ E PAPL S + P S + P T+ +
Sbjct: 819 STSAPAPKLALRE--TPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQ 876
Query: 324 PVPLLPIRQTLPEDNEEPPALPPRT-----------LEGLQVEEEPVYEAEPEPEPEPEP 372
P +P L + + PA + +EGLQ + + A+ +
Sbjct: 877 PSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFN- 935
Query: 373 EPENDYEDVEEMDRHEQEDEPEGD-------YEEVLEPEDSSFSSALAGSSGCPAGA--- 422
+ND V E E +G Y +++ +S +GSS PA
Sbjct: 936 --KNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRV 993
Query: 423 ---GAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPA 479
A V G +A+Y Y+ +L+F DVI + D WW G G+FP+
Sbjct: 994 ASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVIL-VTKKDGDWWTGTVGDKAGVFPS 1052
Query: 480 NYVKL 484
NYV+L
Sbjct: 1053 NYVRL 1057
Score = 37.4 bits (85), Expect = 0.031
Identities = 20/58 (34%), Positives = 26/58 (44%), Gaps = 5/58 (8%)
Query: 433 AVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHG-----HFGLFPANYVKLL 485
A + Y G ++L+ P +I + GWW G G FPANYVKLL
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 60.8 bits (146), Expect = 3e-09
Identities = 25/51 (49%), Positives = 32/51 (62%)
Query: 435 ALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLL 485
ALYD++ E EL F D+IT +DE W+ G HGH G FP NYV++L
Sbjct: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEIL 347
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 60.5 bits (145), Expect = 3e-09
Identities = 55/187 (29%), Positives = 79/187 (42%), Gaps = 34/187 (18%)
Query: 249 KRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPA-------VPAPLPKKISS- 300
K+K K +V ++ +E+ V E P P E P VP P+PKK+ +
Sbjct: 9969 KKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAP 10028
Query: 301 -------------EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQT---LPEDNEEPPAL 344
E PV P E+ P + E P L+P + +P+ E PP
Sbjct: 10029 PAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVP-EVPKKLIPEEKKPTPVPKKVEAPPPK 10087
Query: 345 PPRTLEGLQV------EEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYE 398
P+ E + V EEE ++E E PE E PE E + EE+ E+E PE E
Sbjct: 10088 VPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPE---E 10144
Query: 399 EVLEPED 405
E + PE+
Sbjct: 10145 EEIPPEE 10151
Score = 54.3 bits (129), Expect = 2e-07
Identities = 49/151 (32%), Positives = 68/151 (45%), Gaps = 11/151 (7%)
Query: 247 EEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPV 306
E +K E+K A ++ E A + PE P+ +I E+ P P+PKK+ + PP
Sbjct: 10034 EVPKKPVPEKKVPVPAPKKVE--APPAKVPEVPKKLIPEEKK--PTPVPKKVEA---PPP 10086
Query: 307 GTPPSSESEPVRTSREHPVPLLPIRQTLPEDN---EEPPALPPRTLEGLQVEEEPVYEAE 363
P E PV + +L + +PE+ EE LP E L EEE + E E
Sbjct: 10087 KVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEE-EVLPEEEEVLPEEE 10145
Query: 364 PEPEPEPEPEPENDYEDVEEMDRHEQEDEPE 394
P E E PE +Y EE E+E PE
Sbjct: 10146 EIPPEEEEVPPEEEYVPEEEEFVPEEEVLPE 10176
Score = 52.0 bits (123), Expect = 1e-06
Identities = 50/170 (29%), Positives = 77/170 (45%), Gaps = 14/170 (8%)
Query: 243 ESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPA----PLPKKI 298
E +A E+ E E+ + A Q K PE P + ++P +P +PK++
Sbjct: 10670 EEVALEEPPAEVVEEPEPAAP-PQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEV 10728
Query: 299 SSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQT-LPEDNEEPPALPPRTLEGLQVEEE 357
E P+ P E+ P + E P ++P ++ +P+ E PPA P + +EE+
Sbjct: 10729 VPEKKVPLVVPKKPEAPPAKVP-EVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEK 10787
Query: 358 PVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQ---EDEPEGDYEEVLEPE 404
P A P PE P PE YE+ EE+ E+ E+E E EPE
Sbjct: 10788 P---AVPVPERAESPPPE-VYEEPEEIAPEEEIAPEEEKPVPVAEEEEPE 10833
Score = 48.9 bits (115), Expect = 1e-05
Identities = 50/180 (27%), Positives = 79/180 (43%), Gaps = 27/180 (15%)
Query: 239 KAKFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPA----VPAPL 294
K F S EE+ E +++ ++ A++KR P+ E+PA P P+
Sbjct: 9246 KMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPI 9305
Query: 295 PKKISSEAWPPVGTPPS----SESEPVRTSREHP-----VPLLPIRQTLPED-------- 337
PKK+ A P V P E +PV ++ P VP +P ++ +PE+
Sbjct: 9306 PKKVEPPA-PKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVP-KKPVPEEKIPVPVAK 9363
Query: 338 -NEEPPALPPRTLEGLQVEEE--PVYEAEPEPEPE-PEPEPENDYEDVEEMDRHEQEDEP 393
E PPA P +G+ EE+ V + E P P PE + E+ + + R E+E P
Sbjct: 9364 KKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPP 9423
Score = 48.1 bits (113), Expect = 2e-05
Identities = 53/178 (29%), Positives = 78/178 (43%), Gaps = 31/178 (17%)
Query: 247 EEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAP------------L 294
E +K EEK ++ E A + PE P+ + ++ VPAP +
Sbjct: 10006 EVPKKPVPEEKVPVPVPKKVE--APPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEV 10063
Query: 295 PKKISSEAWPPVGTPPSSESEPVRTSREH-PVPLLPIRQTLPEDNE---EPPALPPRTLE 350
PKK+ E P P E+ P + ++ PVP+ P+ LP++ E E +P E
Sbjct: 10064 PKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPV-PV--ALPQEEEVLFEEEIVPEE--E 10118
Query: 351 GLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDY---EEVLEPED 405
L EEE + E E E PE E + EE+ E+E PE +Y EE PE+
Sbjct: 10119 VLPEEEEVLPE-----EEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEE 10171
Score = 46.2 bits (108), Expect = 7e-05
Identities = 66/252 (26%), Positives = 92/252 (36%), Gaps = 94/252 (37%)
Query: 243 ESMAEEK----RKREEEEKAQQVARRQQERKAVTK-------------RSPEAPQPVIAM 285
E + EEK KR E E A+ R QE+K V K + PEAP+ ++
Sbjct: 9533 EYVVEEKLHIISKRVEAEPAEVTER--QEKKIVLKPKIPAKIEEPPPAKVPEAPKKIV-- 9588
Query: 286 EEPAVPAPLPKKISSEAWPPVGTP-------PSSESEPVRTSREHPVPL----------- 327
E VPAP+PKK E PP P P + P E P+P
Sbjct: 9589 PEKKVPAPVPKK---EKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQ 9645
Query: 328 ------------LPIRQTLPED-----------------NEEPPALPPRTLEGLQVEEEP 358
P + +PE+ EEPPA + + V+EE
Sbjct: 9646 EEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRV-VKEEK 9704
Query: 359 VYEAEPEPEPEPEPE---------------------PENDYEDVEEMDRHE-QEDEPEGD 396
V P+ EP+P E E +YE+ EE D E +E EP +
Sbjct: 9705 VSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEE 9764
Query: 397 YEEVLEPEDSSF 408
Y++ E E+ +
Sbjct: 9765 YDQYEEYEEREY 9776
Score = 45.8 bits (107), Expect = 9e-05
Identities = 41/135 (30%), Positives = 59/135 (43%), Gaps = 9/135 (6%)
Query: 273 KRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQ 332
K+ PEA P P VP PK++ E P P E PV+ E P ++P ++
Sbjct: 10564 KKVPEAIPPKPESPPPEVPEA-PKEVVPEKKVPAAPPKKPEVTPVKVP-EAPKEVVPEKK 10621
Query: 333 TL---PEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQ 389
P+ E PP P + + V E+ V EA P P+PE P +E+ EE+ E
Sbjct: 10622 VPVPPPKKPEVPPTKVPEVPK-VAVPEKKVPEAIP---PKPESPPPEVFEEPEEVALEEP 10677
Query: 390 EDEPEGDYEEVLEPE 404
E + E P+
Sbjct: 10678 PAEVVEEPEPAAPPQ 10692
Score = 45.1 bits (105), Expect = 1e-04
Identities = 41/143 (28%), Positives = 62/143 (43%), Gaps = 19/143 (13%)
Query: 254 EEEKAQQVARRQQERKAVTKRSPE--APQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPS 311
EE+ A V R + PE AP+ IA EE P ++ E P V PP+
Sbjct: 10785 EEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEK-----PVPVAEEEEPEV-PPPA 10838
Query: 312 SESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPE 371
EP + E VP++ ++P A PP+ E +V E+P + P P P P
Sbjct: 10839 VPEEPKKIIPEKKVPVI----------KKPEAPPPKEPEPEKVIEKPKLKPRP-PPPPPA 10887
Query: 372 PEPENDYEDVEEMDRHEQEDEPE 394
P E+ E + ++ ++ PE
Sbjct: 10888 PPKEDVKEKIFQLKAIPKKKVPE 10910
Score = 44.7 bits (104), Expect = 2e-04
Identities = 46/168 (27%), Positives = 66/168 (39%), Gaps = 16/168 (9%)
Query: 247 EEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPK----KISSEA 302
EE + E+ Q+ + ++ AVTK+ EAP EEP P K K E
Sbjct: 9629 EEPLPAKVTERHMQITQEEKVLVAVTKK--EAPPKARVPEEPKRAVPEEKVLKLKPKREE 9686
Query: 303 WPPVGTPP------SSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEE 356
PP E + + P P+ + T+ E+ E L + + EE
Sbjct: 9687 EPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEV--TIMEEKERAYTLEEEAVSVQREEE 9744
Query: 357 EPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPE 404
YE E E E EP +Y+ EE + E E E + E + EPE
Sbjct: 9745 YEEYEEYDYKEFE-EYEPTEEYDQYEEYEEREYERYEEHE-EYITEPE 9790
Score = 43.5 bits (101), Expect = 4e-04
Identities = 43/143 (30%), Positives = 62/143 (43%), Gaps = 25/143 (17%)
Query: 277 EAPQPVIAMEEPAVPAPL----PKKISSEAWPPV----GTPPSSESEPVRT-------SR 321
E P PV EEP VP P PKKI E PV PP E EP + R
Sbjct: 10821 EKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPR 10880
Query: 322 EHPVPLLPIRQTLPEDNEEPPALPPRTL-EGLQVEEE----PVYEAEPEPE-----PEPE 371
P P P ++ + E + A+P + + E QV E+ P+ E + PE +
Sbjct: 10881 PPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERK 10940
Query: 372 PEPENDYEDVEEMDRHEQEDEPE 394
PEP+ + + + +E+EP+
Sbjct: 10941 PEPKEEVVLKSVLRKRPEEEEPK 10963
Score = 42.7 bits (99), Expect = 7e-04
Identities = 48/168 (28%), Positives = 69/168 (41%), Gaps = 18/168 (10%)
Query: 241 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS 300
++E E + E EK V +E ++P A A+ E VP P+PKK+
Sbjct: 9775 EYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLK- 9833
Query: 301 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEE--- 357
PP PP EP + E + I + E EP A P + + EE+
Sbjct: 9834 ---PP---PPKVPEEPKKVFEEK--IRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPV 9885
Query: 358 PVYEAEPE---PEPEPEPEPEN---DYEDVEEMDRHEQEDEPEGDYEE 399
P E P PE E EPE + E V ++ + E+E E +EE
Sbjct: 9886 PRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEE 9933
Score = 42.0 bits (97), Expect = 0.001
Identities = 49/178 (27%), Positives = 70/178 (39%), Gaps = 30/178 (16%)
Query: 247 EEKR---KREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEE--------------PA 289
EEKR +EEE +V +E + PE P + +EE P
Sbjct: 10220 EEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPE 10279
Query: 290 VPAPLPKKISSEAWPPVGT----PPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPP--- 342
P P+PKK+ + PP P PV+ P + + + +PE P
Sbjct: 10280 APTPVPKKVEA---PPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKKE 10336
Query: 343 ALPPRTLEGLQVEEEPVYEA-EPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEE 399
A+PP +G V EE V A E + E E +VEE+ E+ E E +EE
Sbjct: 10337 AVPP--AKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEE 10392
Score = 42.0 bits (97), Expect = 0.001
Identities = 34/125 (27%), Positives = 46/125 (36%), Gaps = 12/125 (9%)
Query: 259 QQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVR 318
++ R +E + + PE P + E VP P KK P PP P
Sbjct: 10479 EEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKK-------PEAPPPKVPEAPKE 10531
Query: 319 TSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDY 378
E VP+ P P+ E PP P + E++ P+PE P PE
Sbjct: 10532 VVPEKKVPVPP-----PKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPK 10586
Query: 379 EDVEE 383
E V E
Sbjct: 10587 EVVPE 10591
Score = 41.6 bits (96), Expect = 0.002
Identities = 40/162 (24%), Positives = 72/162 (44%), Gaps = 21/162 (12%)
Query: 247 EEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPV 306
EEK+ + + + A ++ +K V K P+ I + P +P K P
Sbjct: 8973 EEKKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKPPPPTTLIPAKA------PE 9026
Query: 307 GTPPSSESEPVRTSREHPVPLLPIRQTLPEDNE----EPPALPPRTLEGLQVEEEPVYEA 362
SS++E V+ + + ++ + ++ E + A+ ++ EEP E
Sbjct: 9027 IIDVSSKAEEVK------IMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDEL 9080
Query: 363 EPEPEPEP--EP---EPENDYEDVEEMDRHEQEDEPEGDYEE 399
E EP EP +P EP+ DYE+++ + E +E E D+EE
Sbjct: 9081 EVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEE 9122
Score = 40.8 bits (94), Expect = 0.003
Identities = 50/204 (24%), Positives = 82/204 (40%), Gaps = 20/204 (9%)
Query: 205 VDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKAKFESMAEEKRKREEEEKAQQVARR 264
V K V ++ P A KK P +G+ + + +R+ ++ ++
Sbjct: 9347 VPKKPVPEEKIPVPV-AKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKK 9405
Query: 265 Q--QERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSRE 322
+ +ERK V ++ E P P P VPA LPKK PV P + PV +++
Sbjct: 9406 KVPEERKPVPRKEEEVPPP------PKVPA-LPKK-------PV--PEEKVAVPVPVAKK 9449
Query: 323 HPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVE 382
P P + + + + A + Q E +E E E E E V
Sbjct: 9450 APPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVY 9509
Query: 383 EMDRHEQEDEPE-GDYEEVLEPED 405
+ E+E+E E +YE + EPE+
Sbjct: 9510 REEEREEEEEAEVTEYEVMEEPEE 9533
Score = 40.8 bits (94), Expect = 0.003
Identities = 42/149 (28%), Positives = 61/149 (40%), Gaps = 17/149 (11%)
Query: 269 KAVTKRSPEAPQPVIAMEEPAVPAPLPKK-----ISSEAWPPVGTPPSSESEPVRTSREH 323
+A + PEAP+ V+ E VP P PKK P P E + E
Sbjct: 10519 EAPPPKVPEAPKEVVP--EKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPES 10576
Query: 324 PVPLLPI--RQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPE---PEPEPENDY 378
P P +P ++ +PE ++ PA PP+ E V+ V EA E PE P P P+
Sbjct: 10577 PPPEVPEAPKEVVPE--KKVPAAPPKKPEVTPVK---VPEAPKEVVPEKKVPVPPPKKPE 10631
Query: 379 EDVEEMDRHEQEDEPEGDYEEVLEPEDSS 407
++ + PE E + P+ S
Sbjct: 10632 VPPTKVPEVPKVAVPEKKVPEAIPPKPES 10660
Score = 40.0 bits (92), Expect = 0.005
Identities = 35/115 (30%), Positives = 48/115 (41%), Gaps = 8/115 (6%)
Query: 276 PEAPQPVIAMEEPAVPAP----LPKKISSEAWPPVGTPPSSESEPVRTSR--EHPVPLLP 329
PE PV ++P P P PK++ E PV P E P + + VP
Sbjct: 10506 PEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKK 10565
Query: 330 IRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEP-EPEPEPEPEPENDYEDVEE 383
+ + +P E PP P + + V E+ V A P +PE P PE E V E
Sbjct: 10566 VPEAIPPKPESPPPEVPEAPKEV-VPEKKVPAAPPKKPEVTPVKVPEAPKEVVPE 10619
Score = 38.9 bits (89), Expect = 0.011
Identities = 32/114 (28%), Positives = 46/114 (40%), Gaps = 12/114 (10%)
Query: 268 RKAVTKRSPEAPQPVIAME------EPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSR 321
RK + +R PE + V+ E P PKK+ P V PP P +
Sbjct: 10933 RKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPP-----PPKPVE 10987
Query: 322 EHPVPLLPIRQT-LPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEP 374
E VP + R+ +PE + P P L + + +P E + P EPEP
Sbjct: 10988 EVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEP 11041
Score = 38.5 bits (88), Expect = 0.014
Identities = 33/141 (23%), Positives = 56/141 (39%), Gaps = 42/141 (29%)
Query: 248 EKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIA------MEEPAVPAPLPKKISSE 301
EK+ R+ + + + + K+V ++ PE +P + +++PAVP P P K
Sbjct: 10929 EKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPK---- 10984
Query: 302 AWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYE 361
P P T RE +P EP +P +
Sbjct: 10985 -------PVEEVEVPTVTKRERKIP-------------EPTKVP------------EIKP 11012
Query: 362 AEPEPEPEPEPEPENDYEDVE 382
A P P PEP+P+PE + + ++
Sbjct: 11013 AIPLPAPEPKPKPEAEVKTIK 11033
Score = 38.1 bits (87), Expect = 0.018
Identities = 31/105 (29%), Positives = 45/105 (42%), Gaps = 6/105 (5%)
Query: 273 KRSPEAPQPV-IAMEEPAVPAPLP---KKISSEAWPPVGTPPSSESEPVRTSREHPVPLL 328
K PE +PV + +EPA P +P KK E PV E+ P + +
Sbjct: 9322 KPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVT 9381
Query: 329 PIRQTLPEDNEE--PPALPPRTLEGLQVEEEPVYEAEPEPEPEPE 371
+ T+ EE PPA+P + + E +PV E E P P+
Sbjct: 9382 EEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPK 9426
Score = 38.1 bits (87), Expect = 0.018
Identities = 43/144 (29%), Positives = 63/144 (43%), Gaps = 22/144 (15%)
Query: 247 EEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAME-EPAVPAPLP-----KKISS 300
EE+ EEEE + E + V + P+ + E +P VP P P KK++
Sbjct: 10137 EEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTE 10196
Query: 301 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY 360
+ V P E+ P + E P + R LP++ E P ++V EEP
Sbjct: 10197 KK---VVIPKKEEAPPAKVP-EVPKKVEEKRIILPKEEEVLP---------VEVTEEP-- 10241
Query: 361 EAEPEPEPEPEPEPENDYEDVEEM 384
E EP E E EP + E+VEE+
Sbjct: 10242 EEEPISEEEIPEEPPS-IEEVEEV 10264
Score = 37.7 bits (86), Expect = 0.024
Identities = 37/135 (27%), Positives = 56/135 (41%), Gaps = 22/135 (16%)
Query: 250 RKREEEEKAQQVARRQQERK-------------------AVTKRSPEAPQPVIAME-EPA 289
RKR EEE+ + ++ ++ K VTKR + P+P E +PA
Sbjct: 10954 RKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPA 11013
Query: 290 VPAPLPK-KISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRT 348
+P P P+ K EA PP E EP + VP++ + EE A P
Sbjct: 11014 IPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEE-AAKPKGP 11072
Query: 349 LEGLQVEEEPVYEAE 363
++G+ + EAE
Sbjct: 11073 IKGVPKKTPSPIEAE 11087
Score = 37.0 bits (84), Expect = 0.040
Identities = 35/125 (28%), Positives = 49/125 (39%), Gaps = 20/125 (16%)
Query: 247 EEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPV 306
EE EEEE + E + +T+ PV E P P P KK PV
Sbjct: 9919 EEYLVEEEEEYIHE------EEEFITEEEVVPVIPVKVPEVPRKPVPEEKK-------PV 9965
Query: 307 GTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEP 366
P E+ P + P + +P+ + PPA P +V ++PV E E P
Sbjct: 9966 PVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVP------EVPKKPVPE-EKVP 10018
Query: 367 EPEPE 371
P P+
Sbjct: 10019 VPVPK 10023
Score = 34.7 bits (78), Expect = 0.20
Identities = 35/115 (30%), Positives = 44/115 (38%), Gaps = 38/115 (33%)
Query: 276 PEAPQPVIAMEEPAVPAP------------LPKKISSEAWPPVGTPPSSESEPVRTSREH 323
PEAP+ V+ ++ VP P +PK E P PP ES P E
Sbjct: 10610 PEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEE- 10668
Query: 324 PVPLLPIRQTLPED--NEEPPALPPRTLEGLQVEEEPVYEAEPE---PEPEPEPE 373
PE+ EEPPA +V EEP A P+ P +P PE
Sbjct: 10669 -----------PEEVALEEPPA---------EVVEEPEPAAPPQVTVPPKKPVPE 10703
Score = 33.9 bits (76), Expect = 0.34
Identities = 40/158 (25%), Positives = 62/158 (39%), Gaps = 35/158 (22%)
Query: 251 KREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAME-----------EPAVPAPLPKKI- 298
K+ EK ++ +RR +E K + PE + ++ + E VPA KK+
Sbjct: 9182 KKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMV 9241
Query: 299 --------SSEAWPPVG-TPPSSESEPVRTSREH--------PVPLLPIRQTLPEDNEEP 341
+S V T P + E V + H P P +P P E
Sbjct: 9242 ISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVA 9301
Query: 342 PALPPRTLEG-----LQVEEEPVYEAEPEPEPEPEPEP 374
P P+ +E +V ++PV E E +P P P+ EP
Sbjct: 9302 PVPIPKKVEPPAPKVPEVPKKPVPE-EKKPVPVPKKEP 9338
Score = 33.9 bits (76), Expect = 0.34
Identities = 70/305 (22%), Positives = 117/305 (38%), Gaps = 73/305 (23%)
Query: 127 ERDRA---DKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEK 183
E++RA ++ AV + E E++ + DY E D++++ Y+ + E E+
Sbjct: 9725 EKERAYTLEEEAVSVQREEEYEEY-EEYDYKEFEEYEPTEEYDQYEE----YEER-EYER 9778
Query: 184 HESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGT-RGLKAKF 242
+E +Y + I V + V P KK P E + LK
Sbjct: 9779 YEEHEEYITE--PEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPP 9836
Query: 243 ESMAEEKRKREEEEKAQQVARRQQERKAV-TKRSPEAPQPVIAMEEPAVPAPLPKKISSE 301
+ EE +K EE+ + +R++E+ + P P+ V+A E+ P+P+K E
Sbjct: 9837 PKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEK----VPVPRK---E 9889
Query: 302 AWPPVGTPP-SSESEPVRTS-----------------------------REHPVPLLPI- 330
PPV P E EP + E VP++P+
Sbjct: 9890 VAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVK 9949
Query: 331 -----RQTLPEDN---------EEPPA----LPPRTLEGLQV----EEEPVYEAEPEPEP 368
R+ +PE+ E PPA +P + E + V +E+P PE
Sbjct: 9950 VPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPK 10009
Query: 369 EPEPE 373
+P PE
Sbjct: 10010 KPVPE 10014
Score = 31.6 bits (70), Expect = 1.7
Identities = 37/147 (25%), Positives = 63/147 (42%), Gaps = 16/147 (10%)
Query: 255 EEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSES 314
EEK R + +KAV K + + V+A + P ++I + PP P+
Sbjct: 8973 EEKKPPPKRIEVTKKAVKKDAKK----VVAKPKEMTPR---EEIVKKPPPPTTLIPAKAP 9025
Query: 315 EPVR-TSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPE 373
E + +S+ V ++ I + E+ + + + E+ E+ EP E E E
Sbjct: 9026 EIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKK--QAVHKEKRVFIESFEEPYDELEVE 9083
Query: 374 PENDYEDVEEMDRHEQEDEPEGDYEEV 400
P Y + E +E+ DE DYEE+
Sbjct: 9084 P---YTEPFEQPYYEEPDE---DYEEI 9104
Score = 29.3 bits (64), Expect = 8.4
Identities = 31/126 (24%), Positives = 50/126 (39%), Gaps = 33/126 (26%)
Query: 248 EKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVG 307
E+ + EEE + ++V R + +A + V E+P P P +IS + PP
Sbjct: 10405 EQHRVEEEHRVEKVHRVIEVFEA---------EEVEVFEKPKAP-PKGPEISEKIIPP-- 10452
Query: 308 TPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPE 367
++ P ++P +EPPA P + + VEE+ EP
Sbjct: 10453 -------------KKPPTKVVP--------RKEPPAKVPEVPKKIVVEEKVRVPEEPRVP 10491
Query: 368 PEPEPE 373
P PE
Sbjct: 10492 PTKVPE 10497
>gi|27544941 myosin IF [Homo sapiens]
Length = 1098
Score = 60.1 bits (144), Expect = 4e-09
Identities = 57/221 (25%), Positives = 73/221 (33%), Gaps = 56/221 (25%)
Query: 268 RKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVPL 327
RK + K P PA P + + G PPS+ P
Sbjct: 927 RKGMAKGKPRRSSQAPTRAAPAPPRGMDRN---------GVPPSARGGP----------- 966
Query: 328 LPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRH 387
LP+ PP PP T G A P P E ++ +V
Sbjct: 967 LPLEIMSGGGTHRPPRGPPSTSLG----------ASRRPRARPPSEHNTEFLNV------ 1010
Query: 388 EQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAV-----ALGISAVALYDYQGE 442
P+ S G G G G ALY Y G+
Sbjct: 1011 ---------------PDQGMAGMQRKRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQ 1055
Query: 443 GSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVK 483
DELSF+ ++VI + GWW+GR HG GLFP NYV+
Sbjct: 1056 DVDELSFNVNEVIEILMEDPSGWWKGRLHGQEGLFPGNYVE 1096
>gi|61743948 abl-interactor 1 isoform d [Homo sapiens]
Length = 476
Score = 59.7 bits (143), Expect = 6e-09
Identities = 43/154 (27%), Positives = 64/154 (41%), Gaps = 37/154 (24%)
Query: 330 IRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQ 389
+++ + + PP PP ++ P+++ P P P P DYED E
Sbjct: 353 VQENIADSPTPPPPPPP--------DDIPMFDDSPPPPPPPPV----DYEDEEAAVVQYN 400
Query: 390 EDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSF 449
+ +GD PA A + VA+YDY + DELSF
Sbjct: 401 DPYADGD----------------------PAWAPKNYIE---KVVAIYDYTKDKDDELSF 435
Query: 450 DPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVK 483
+I I+ D+GW+ G C+ GLFP NYV+
Sbjct: 436 MEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 469
>gi|61743944 abl-interactor 1 isoform b [Homo sapiens]
Length = 481
Score = 59.7 bits (143), Expect = 6e-09
Identities = 43/154 (27%), Positives = 64/154 (41%), Gaps = 37/154 (24%)
Query: 330 IRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQ 389
+++ + + PP PP ++ P+++ P P P P DYED E
Sbjct: 358 VQENIADSPTPPPPPPP--------DDIPMFDDSPPPPPPPPV----DYEDEEAAVVQYN 405
Query: 390 EDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSF 449
+ +GD PA A + VA+YDY + DELSF
Sbjct: 406 DPYADGD----------------------PAWAPKNYIE---KVVAIYDYTKDKDDELSF 440
Query: 450 DPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVK 483
+I I+ D+GW+ G C+ GLFP NYV+
Sbjct: 441 MEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 474
>gi|61743942 abl-interactor 1 isoform a [Homo sapiens]
Length = 508
Score = 59.7 bits (143), Expect = 6e-09
Identities = 43/154 (27%), Positives = 64/154 (41%), Gaps = 37/154 (24%)
Query: 330 IRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQ 389
+++ + + PP PP ++ P+++ P P P P DYED E
Sbjct: 385 VQENIADSPTPPPPPPP--------DDIPMFDDSPPPPPPPPV----DYEDEEAAVVQYN 432
Query: 390 EDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSF 449
+ +GD PA A + VA+YDY + DELSF
Sbjct: 433 DPYADGD----------------------PAWAPKNYIE---KVVAIYDYTKDKDDELSF 467
Query: 450 DPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVK 483
+I I+ D+GW+ G C+ GLFP NYV+
Sbjct: 468 MEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 501
>gi|61743946 abl-interactor 1 isoform c [Homo sapiens]
Length = 452
Score = 59.3 bits (142), Expect = 8e-09
Identities = 44/147 (29%), Positives = 61/147 (41%), Gaps = 36/147 (24%)
Query: 337 DNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGD 396
D+ PP PP ++ P+++ P P P P DYED E + +GD
Sbjct: 335 DSPTPPPPPPP-------DDIPMFDDSPPPPPPPPV----DYEDEEAAVVQYNDPYADGD 383
Query: 397 YEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDVIT 456
PA A + VA+YDY + DELSF +I
Sbjct: 384 ----------------------PAWAPKNYIE---KVVAIYDYTKDKDDELSFMEGAIIY 418
Query: 457 DIEMVDEGWWRGRCHGHFGLFPANYVK 483
I+ D+GW+ G C+ GLFP NYV+
Sbjct: 419 VIKKNDDGWYEGVCNRVTGLFPGNYVE 445
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 57.8 bits (138), Expect = 2e-08
Identities = 67/296 (22%), Positives = 114/296 (38%), Gaps = 33/296 (11%)
Query: 197 QYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKAKFESMAEEKRK-REEE 255
++ + + +D+S +E P+ ++ PI G+ L++ S+A + +E+
Sbjct: 690 EWRLLHEDLDESDDDMDEKLQPSPNRREDRPISFYQLGSNQLQSNAVSLARDAANLAKEK 749
Query: 256 EKAQQVARRQQERK-AVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSES 314
++A + Q E A+ SP QP A P P P+ + + P PP +++
Sbjct: 750 QRAFMPSILQNETYGALLSGSPPPAQPAAPSTTSAPPLP-PRNVGKDPLTPTPPPPVAKT 808
Query: 315 EPVRTSREHPVPLLPIRQTLPEDNE-EPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPE 373
V + P P P ++ PP LPP+ P P+ +P
Sbjct: 809 PSVMEALSQPSKPAP-----PGISQIRPPPLPPQP---------------PSRLPQKKPA 848
Query: 374 PENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISA 433
P D + + +P G + S+A+ P + A L
Sbjct: 849 PGAD-----KSTPLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKR 903
Query: 434 V-ALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCH---GHFGLFPANYVKLL 485
V ALY+ + DEL+F DVI D+ WW G G G FP ++V +
Sbjct: 904 VKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFI 959
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 57.4 bits (137), Expect = 3e-08
Identities = 33/79 (41%), Positives = 42/79 (53%), Gaps = 11/79 (13%)
Query: 409 SSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMV-----DE 463
+S+ + SSG A AGAG A ALYDY+ G DELS ++ + DE
Sbjct: 25 ASSSSTSSGGSASAGAGLWA------ALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDE 78
Query: 464 GWWRGRCHGHFGLFPANYV 482
GWW G+ G+FPANYV
Sbjct: 79 GWWAGQVQRRLGIFPANYV 97
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 56.6 bits (135), Expect = 5e-08
Identities = 22/53 (41%), Positives = 34/53 (64%)
Query: 431 ISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVK 483
+ A+ +DYQ + DEL+ ++IT+I D GWW G+ +G GLFP N+V+
Sbjct: 2 VEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVR 54
Score = 51.2 bits (121), Expect = 2e-06
Identities = 21/52 (40%), Positives = 33/52 (63%), Gaps = 2/52 (3%)
Query: 436 LYDYQGEGSDELSFDPDDVITDI--EMVDEGWWRGRCHGHFGLFPANYVKLL 485
++ Y+ + DEL+ D++T I + +D GWW G +G G+FP N+VKLL
Sbjct: 275 IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLL 326
Score = 47.8 bits (112), Expect = 2e-05
Identities = 19/49 (38%), Positives = 29/49 (59%)
Query: 437 YDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLL 485
+ Y + DEL D+I + V+EGWW G +G G+FP+N++K L
Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 155
>gi|155030232 proline, glutamic acid and leucine rich protein 1
[Homo sapiens]
Length = 1130
Score = 56.2 bits (134), Expect = 6e-08
Identities = 52/145 (35%), Positives = 62/145 (42%), Gaps = 37/145 (25%)
Query: 276 PEAPQPVIAMEEP----AVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVP---LL 328
P A PV A EEP A P PLP PP PP PVP L
Sbjct: 817 PTASPPVPAKEEPEELPAAPGPLP--------PPPPPPP-------------PVPGPVTL 855
Query: 329 PIRQTLPEDNEEPPALPPRTLEGLQV------EEEPVYEAEPEPEPEPEPEPENDYEDVE 382
P Q +PE PP E L V +EE E E E E E E E E D+E+ E
Sbjct: 856 PPPQLVPEGTPGGGG-PPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEE 914
Query: 383 EMDRH--EQEDEPEGDYEEVLEPED 405
E + E+E+E E ++EE E E+
Sbjct: 915 EDEEEYFEEEEEEEEEFEEEFEEEE 939
Score = 50.1 bits (118), Expect = 5e-06
Identities = 41/140 (29%), Positives = 59/140 (42%), Gaps = 8/140 (5%)
Query: 276 PEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTP----PSSESEPVRTSREHPVPLLPIR 331
P AP P+ P P P P + P GTP P + E + +
Sbjct: 833 PAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEE 892
Query: 332 QTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQED 391
+ E+ EE E + +EE +E E E E E E E E + ++EE E+E+
Sbjct: 893 EEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEE----EEEE 948
Query: 392 EPEGDYEEVLEPEDSSFSSA 411
E E + EE+ E ED F +A
Sbjct: 949 EDEEEEEELEEVEDLEFGTA 968
Score = 46.2 bits (108), Expect = 7e-05
Identities = 48/184 (26%), Positives = 70/184 (38%), Gaps = 13/184 (7%)
Query: 243 ESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAP-LPKKISSE 301
E EE+ + E+EE+ +++ + E P PA+P P P K+ E
Sbjct: 939 EGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPE 998
Query: 302 AWPPVGT------PPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVE 355
P G P + E T+ LP + + + E P A PP VE
Sbjct: 999 PEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQE---LVE 1055
Query: 356 EEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGS 415
EEP + P E E E +D E+E E E + E + E E ++ LA
Sbjct: 1056 EEP---SAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADF 1112
Query: 416 SGCP 419
CP
Sbjct: 1113 IDCP 1116
Score = 35.0 bits (79), Expect = 0.15
Identities = 37/162 (22%), Positives = 57/162 (35%), Gaps = 23/162 (14%)
Query: 243 ESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEA 302
E EE+ + EEEE+ ++ ++E + E + E L ++ E
Sbjct: 891 EEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEE- 949
Query: 303 WPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEA 362
E E + + E PP LPP P E+
Sbjct: 950 ---------DEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPAL---------PPPES 991
Query: 363 EPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPE 404
P+ +PEPEPEP + E++ E+E D L PE
Sbjct: 992 PPKVQPEPEPEPGL----LLEVEEPGTEEERGADTAPTLAPE 1029
>gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]
Length = 368
Score = 55.8 bits (133), Expect = 8e-08
Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 7/125 (5%)
Query: 361 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA 420
EA P+ E +P+P E D E E + G + P+ ++ SS +
Sbjct: 246 EASSRPKREYKPKPR------EPFDLGEPE-QSNGGFPCTTAPKIAASSSFRSSDKPIRT 298
Query: 421 GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN 480
+ + S ALYD++ E EL F DVIT +DE W+ G G G FP +
Sbjct: 299 PSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLS 358
Query: 481 YVKLL 485
YV++L
Sbjct: 359 YVEVL 363
>gi|55956916 myosin IE [Homo sapiens]
Length = 1108
Score = 55.8 bits (133), Expect = 8e-08
Identities = 25/48 (52%), Positives = 31/48 (64%)
Query: 435 ALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYV 482
ALY Y + +DELSF+ +D+I I+ GWW GR G GLFP NYV
Sbjct: 1058 ALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYV 1105
>gi|24308229 protein kinase C and casein kinase substrate in neurons
1 [Homo sapiens]
Length = 444
Score = 55.5 bits (132), Expect = 1e-07
Identities = 29/58 (50%), Positives = 36/58 (62%), Gaps = 2/58 (3%)
Query: 430 GISAVALYDYQGEGSDELSFDPDDVITDIEMVDE-GWWRGRC-HGHFGLFPANYVKLL 485
G+ ALYDY G+ DELSF D +T + DE GW RGR G GL+PANYV+ +
Sbjct: 387 GVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI 444
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 55.5 bits (132), Expect = 1e-07
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 434 VALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKL 484
+A+YDY DELSF +I + D WW+G +G GLFP+NYVK+
Sbjct: 1106 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKM 1156
Score = 52.4 bits (124), Expect = 9e-07
Identities = 66/284 (23%), Positives = 107/284 (37%), Gaps = 35/284 (12%)
Query: 223 KKTTPIEAASSGTRGL----KAKFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEA 278
KK EAA +G K EEK+KR +EEK Q+ + ++ERKA K+ +
Sbjct: 658 KKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQ-EEERKAEEKQRKDK 716
Query: 279 PQPVIAMEEPAVPAPLPK-------------KISSEAWPPVGTPPSSESEP--VRTSREH 323
++ + L ++S + + + EP + S +
Sbjct: 717 DTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQG 776
Query: 324 PVPLLPIR--QTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDV 381
P + +P E P + L V EP +P DY++V
Sbjct: 777 NFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSAT-STSSEPLSSNQPASVTDYQNV 835
Query: 382 EEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQG 441
+ + S+F+ ++ S P G G V + A AL +
Sbjct: 836 SFSNLTVNTSWQK----------KSAFTRTVSPGSVSPIH-GQGQVVENLKAQALCSWTA 884
Query: 442 EGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLL 485
+ + L+F D+IT +E E WW G HG G FP +YVK++
Sbjct: 885 KKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 927
Score = 40.0 bits (92), Expect = 0.005
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Query: 424 AGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVK 483
+ A ++G +ALY Y +L+F + I + D WW G G+FP+NYVK
Sbjct: 950 SAAYSVGEEYIALYPYSSVEPGDLTFTEGEEIL-VTQKDGEWWTGSIGDRSGIFPSNYVK 1008
Score = 37.7 bits (86), Expect = 0.024
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 5/52 (9%)
Query: 439 YQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHG-----HFGLFPANYVKLL 485
Y GS++LS P +I ++ GWW+G G FPA++VKLL
Sbjct: 1037 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1088
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 55.5 bits (132), Expect = 1e-07
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 434 VALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKL 484
+A+YDY DELSF +I + D WW+G +G GLFP+NYVK+
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKM 1183
Score = 52.4 bits (124), Expect = 9e-07
Identities = 66/284 (23%), Positives = 107/284 (37%), Gaps = 35/284 (12%)
Query: 223 KKTTPIEAASSGTRGL----KAKFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEA 278
KK EAA +G K EEK+KR +EEK Q+ + ++ERKA K+ +
Sbjct: 685 KKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQ-EEERKAEEKQRKDK 743
Query: 279 PQPVIAMEEPAVPAPLPK-------------KISSEAWPPVGTPPSSESEP--VRTSREH 323
++ + L ++S + + + EP + S +
Sbjct: 744 DTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQG 803
Query: 324 PVPLLPIR--QTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDV 381
P + +P E P + L V EP +P DY++V
Sbjct: 804 NFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSAT-STSSEPLSSNQPASVTDYQNV 862
Query: 382 EEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQG 441
+ + S+F+ ++ S P G G V + A AL +
Sbjct: 863 SFSNLTVNTSWQK----------KSAFTRTVSPGSVSPIH-GQGQVVENLKAQALCSWTA 911
Query: 442 EGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLL 485
+ + L+F D+IT +E E WW G HG G FP +YVK++
Sbjct: 912 KKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
Score = 40.0 bits (92), Expect = 0.005
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Query: 424 AGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVK 483
+ A ++G +ALY Y +L+F + I + D WW G G+FP+NYVK
Sbjct: 977 SAAYSVGEEYIALYPYSSVEPGDLTFTEGEEIL-VTQKDGEWWTGSIGDRSGIFPSNYVK 1035
Score = 37.7 bits (86), Expect = 0.024
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 5/52 (9%)
Query: 439 YQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHG-----HFGLFPANYVKLL 485
Y GS++LS P +I ++ GWW+G G FPA++VKLL
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1115
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 55.5 bits (132), Expect = 1e-07
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 434 VALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKL 484
+A+YDY DELSF +I + D WW+G +G GLFP+NYVK+
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKM 1183
Score = 52.4 bits (124), Expect = 9e-07
Identities = 66/284 (23%), Positives = 107/284 (37%), Gaps = 35/284 (12%)
Query: 223 KKTTPIEAASSGTRGL----KAKFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEA 278
KK EAA +G K EEK+KR +EEK Q+ + ++ERKA K+ +
Sbjct: 685 KKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQ-EEERKAEEKQRKDK 743
Query: 279 PQPVIAMEEPAVPAPLPK-------------KISSEAWPPVGTPPSSESEP--VRTSREH 323
++ + L ++S + + + EP + S +
Sbjct: 744 DTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQG 803
Query: 324 PVPLLPIR--QTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDV 381
P + +P E P + L V EP +P DY++V
Sbjct: 804 NFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSAT-STSSEPLSSNQPASVTDYQNV 862
Query: 382 EEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQG 441
+ + S+F+ ++ S P G G V + A AL +
Sbjct: 863 SFSNLTVNTSWQK----------KSAFTRTVSPGSVSPIH-GQGQVVENLKAQALCSWTA 911
Query: 442 EGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLL 485
+ + L+F D+IT +E E WW G HG G FP +YVK++
Sbjct: 912 KKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
Score = 40.0 bits (92), Expect = 0.005
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Query: 424 AGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVK 483
+ A ++G +ALY Y +L+F + I + D WW G G+FP+NYVK
Sbjct: 977 SAAYSVGEEYIALYPYSSVEPGDLTFTEGEEIL-VTQKDGEWWTGSIGDRSGIFPSNYVK 1035
Score = 37.7 bits (86), Expect = 0.024
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 5/52 (9%)
Query: 439 YQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHG-----HFGLFPANYVKLL 485
Y GS++LS P +I ++ GWW+G G FPA++VKLL
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1115
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.130 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,500,864
Number of Sequences: 37866
Number of extensions: 1385175
Number of successful extensions: 17827
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 426
Number of HSP's successfully gapped in prelim test: 1105
Number of HSP's that attempted gapping in prelim test: 9877
Number of HSP's gapped (non-prelim): 6050
length of query: 486
length of database: 18,247,518
effective HSP length: 106
effective length of query: 380
effective length of database: 14,233,722
effective search space: 5408814360
effective search space used: 5408814360
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.