Guide to the Human Genome
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Search of human proteins with 166064038

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|166064038 PAK-interacting exchange factor beta isoform a
[Homo sapiens]
         (646 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|166064038 PAK-interacting exchange factor beta isoform a [Hom...  1300   0.0  
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ...  1300   0.0  
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom...  1125   0.0  
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom...  1125   0.0  
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo...  1125   0.0  
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo...   804   0.0  
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...   132   8e-31
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...   132   1e-30
gi|23308553 spermatogenesis associated 13 [Homo sapiens]              122   8e-28
gi|71274148 pleckstrin homology domain containing, family G (wit...   117   4e-26
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]             109   7e-24
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                   106   8e-23
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                   106   8e-23
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]               103   6e-22
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...    99   2e-20
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]           96   1e-19
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]           96   1e-19
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform...    87   6e-17
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...    86   1e-16
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]    79   1e-14
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...    79   1e-14
gi|45439359 triple functional domain (PTPRF interacting) [Homo s...    79   2e-14
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]           78   2e-14
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]             78   2e-14
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap...    78   2e-14
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ...    78   2e-14
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ...    78   2e-14
gi|39930351 dynamin binding protein [Homo sapiens]                     74   3e-13
gi|55749621 pleckstrin homology domain containing, family G, mem...    73   7e-13
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ...    72   2e-12

>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
           sapiens]
          Length = 646

 Score = 1300 bits (3365), Expect = 0.0
 Identities = 646/646 (100%), Positives = 646/646 (100%)

Query: 1   MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
           MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 1   MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60

Query: 61  REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
           REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 61  REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120

Query: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
           RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180

Query: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
           TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240

Query: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
           ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300

Query: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
           NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360

Query: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
           SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420

Query: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
           SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480

Query: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
           PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540

Query: 541 AYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDE 600
           AYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDE
Sbjct: 541 AYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDE 600

Query: 601 VQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL 646
           VQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL
Sbjct: 601 VQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL 646


>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
           sapiens]
          Length = 646

 Score = 1300 bits (3365), Expect = 0.0
 Identities = 646/646 (100%), Positives = 646/646 (100%)

Query: 1   MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
           MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 1   MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60

Query: 61  REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
           REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 61  REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120

Query: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
           RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180

Query: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
           TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240

Query: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
           ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300

Query: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
           NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360

Query: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
           SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420

Query: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
           SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480

Query: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
           PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540

Query: 541 AYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDE 600
           AYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDE
Sbjct: 541 AYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDE 600

Query: 601 VQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL 646
           VQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL
Sbjct: 601 VQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL 646


>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
           sapiens]
          Length = 753

 Score = 1125 bits (2911), Expect = 0.0
 Identities = 554/555 (99%), Positives = 555/555 (100%)

Query: 1   MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
           MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 129 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 188

Query: 61  REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
           REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 189 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 248

Query: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
           RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 249 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 308

Query: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
           TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 309 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 368

Query: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
           ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 369 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 428

Query: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
           NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 429 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 488

Query: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
           SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 489 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 548

Query: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
           SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 549 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 608

Query: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
           PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 609 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 668

Query: 541 AYCTSAKTRQTLNSS 555
           AYCTSAKTRQTLNS+
Sbjct: 669 AYCTSAKTRQTLNST 683


>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
           sapiens]
          Length = 803

 Score = 1125 bits (2911), Expect = 0.0
 Identities = 554/555 (99%), Positives = 555/555 (100%)

Query: 1   MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
           MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 179 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 238

Query: 61  REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
           REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 239 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 298

Query: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
           RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 299 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 358

Query: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
           TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 359 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 418

Query: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
           ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 419 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 478

Query: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
           NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 479 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 538

Query: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
           SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 539 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 598

Query: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
           SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 599 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 658

Query: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
           PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 659 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 718

Query: 541 AYCTSAKTRQTLNSS 555
           AYCTSAKTRQTLNS+
Sbjct: 719 AYCTSAKTRQTLNST 733


>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
           sapiens]
          Length = 782

 Score = 1125 bits (2911), Expect = 0.0
 Identities = 554/555 (99%), Positives = 555/555 (100%)

Query: 1   MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
           MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 158 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 217

Query: 61  REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
           REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 218 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 277

Query: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
           RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 278 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 337

Query: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
           TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 338 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 397

Query: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
           ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 398 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 457

Query: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
           NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 458 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 517

Query: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
           SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 518 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 577

Query: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
           SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 578 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 637

Query: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
           PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 638 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 697

Query: 541 AYCTSAKTRQTLNSS 555
           AYCTSAKTRQTLNS+
Sbjct: 698 AYCTSAKTRQTLNST 712


>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
           sapiens]
          Length = 776

 Score =  804 bits (2077), Expect = 0.0
 Identities = 405/645 (62%), Positives = 503/645 (77%), Gaps = 44/645 (6%)

Query: 1   MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
           MT+N ++QL+V+A+FNF+QTNEDELS  KGD+I+VTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 155 MTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYV 214

Query: 61  REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
           RE+K+SE+P+SPK+       KGF+T  + K+YY VVLQNIL+TE EY+KELQ++L TYL
Sbjct: 215 REIKSSERPLSPKA------VKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYL 268

Query: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
           RPLQ++  LS+  ++ L+GN EE+C+FQQ L Q+LEEC+K PE Q +VGGC L+LMP  K
Sbjct: 269 RPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFK 328

Query: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
           ++YL YCANHPSAVNVLT+HS+EL +FME +GASSPGIL+LTT LSKPFMRL+KY TLL+
Sbjct: 329 SMYLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQ 388

Query: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
           ELERHMED H D QDI K++ AFK L  QCQ++RKRK+LELQIL+E I+ WEG+DIK LG
Sbjct: 389 ELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLG 448

Query: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
           NV +MSQV++Q    EEK ERYL+LF NVL+MLSASPRMSGFIYQGK+P  G  +T+L++
Sbjct: 449 NVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDE 508

Query: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
            E +   FEI+G+ +ERI+V CNN QD QEW+E L +  +                    
Sbjct: 509 IEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIR-------------------- 548

Query: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
                P+S  + SK +  + + H+    S  G P      GPLEPP+  KPWSLSCLRPA
Sbjct: 549 ----GPASCSSLSKTSSSSCSAHS--SFSSTGQPR-----GPLEPPQIIKPWSLSCLRPA 597

Query: 481 PPLRPSAALCYKE-------DLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDA 533
           PPLRPSAAL YKE       + SKSPKTMKK L KRK ERKPS+EE+  RKSTAALEEDA
Sbjct: 598 PPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDA 657

Query: 534 QILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDT 593
           QILKVIEAYCTSA  +Q   SS+RK+S PQVLLPEEEK+I+EET+SNGQT++EEKSLVDT
Sbjct: 658 QILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDT 717

Query: 594 VYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMND 638
           VYALKDEV+EL+Q+NK+MK+ LEEE ++R+DLEKLVR++LK  ++
Sbjct: 718 VYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDE 762


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score =  132 bits (333), Expect = 8e-31
 Identities = 118/484 (24%), Positives = 208/484 (42%), Gaps = 28/484 (5%)

Query: 21  NEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTL 77
           ++ EL F  GDVI V       WW G +    GWFP+++VR     ++P    +P +G  
Sbjct: 209 DDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNS 268

Query: 78  KSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISY 136
            +   G +  +        V+  IL TE +Y K L+ +   Y+R   + ++  S   +  
Sbjct: 269 GAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRT 328

Query: 137 LMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA-- 193
           + GN+E+I   Q+  V++LE+           +G CFL      + +Y  YC NHP+A  
Sbjct: 329 IFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACV 387

Query: 194 -VNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTD 252
            ++ LT+ S+ +  F   +       + L   L  P  ++ KYP  L EL ++    H D
Sbjct: 388 ELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRD 447

Query: 253 RQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLI 310
            +D++ ++ A KN++    E ++R E   ++     +I +WEG+D+    +    S  L 
Sbjct: 448 FKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELT 507

Query: 311 QCAGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH---- 364
           +    + K+ +R   LF + L+       R     Y+G+L   G+ +  LED ++     
Sbjct: 508 RVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHV 567

Query: 365 --RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPS 421
             +NAF +  G+  +  L+     +  Q W++   ++ +   +   T    S+       
Sbjct: 568 SIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET--GFSITELQRKQ 625

Query: 422 HPVTPSSKHADSKPAPL-TPAYHTLPHPSHHGTPHTTINWGPL---EPPKTPKPWSLSCL 477
             +  S +    KP  +  P Y  L    H   P        L   EP + P  +  S  
Sbjct: 626 AMLNASKQQVTGKPKAVGRPCY--LTRQKHPALPSNRPQQQVLVLAEPRRKPSTFWHSIS 683

Query: 478 RPAP 481
           R AP
Sbjct: 684 RLAP 687


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score =  132 bits (332), Expect = 1e-30
 Identities = 101/407 (24%), Positives = 185/407 (45%), Gaps = 20/407 (4%)

Query: 21  NEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTL 77
           ++ EL F  GDVI V       WW G +    GWFP+++VR     ++P    +P +G  
Sbjct: 209 DDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNS 268

Query: 78  KSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISY 136
            +   G +  +        V+  IL TE +Y K L+ +   Y+R   + ++  S   +  
Sbjct: 269 GAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRT 328

Query: 137 LMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA-- 193
           + GN+E+I   Q+  V++LE+           +G CFL      + +Y  YC NHP+A  
Sbjct: 329 IFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACV 387

Query: 194 -VNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTD 252
            ++ LT+ S+ +  F   +       + L   L  P  ++ KYP  L EL ++    H D
Sbjct: 388 ELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRD 447

Query: 253 RQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLI 310
            +D++ ++ A KN++    E ++R E   ++     +I +WEG+D+    +    S  L 
Sbjct: 448 FKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELT 507

Query: 311 QCAGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH---- 364
           +    + K+ +R   LF + L+       R     Y+G+L   G+ +  LED ++     
Sbjct: 508 RVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHV 567

Query: 365 --RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPT 408
             +NAF +  G+  +  L+     +  Q W++   ++ +   +   T
Sbjct: 568 SIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score =  122 bits (307), Expect = 8e-28
 Identities = 103/413 (24%), Positives = 178/413 (43%), Gaps = 26/413 (6%)

Query: 4   NSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 63
           +  N +   A ++    ++ EL F  GDVI V       WW G    +  WFP+++VR +
Sbjct: 145 SDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVR-L 203

Query: 64  KASEKPVSPKSGTLKSPPKGFDTT------AINKSYYNV-VLQNILETENEYSKELQTVL 116
           + +++ +S  S +  S  +  + +        NK      V++ I++TE  Y K L+ + 
Sbjct: 204 RVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDIC 263

Query: 117 STYLRPLQT-SEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLN 174
             Y+R  +  +   + A ++ + GN+E+I  FQ+  ++ LE+     E     +G CFL 
Sbjct: 264 EGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQ 323

Query: 175 LMPQMKTLYLTYCANHPSAVNVLTEHSEE--LGEFMETKGASSPGILVLTTG-LSKPFMR 231
                  +Y  YC NHP A   L    ++     F E        I +   G L  P  +
Sbjct: 324 NQEGF-AIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQK 382

Query: 232 LDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTE---AI 288
           + KYP  L EL ++    H D  +I+ +  A KN++    E RKRK   +  +     +I
Sbjct: 383 ICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINE-RKRKLESIDKIARWQVSI 441

Query: 289 RNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGK 347
             WEG DI    +    S  L +     +  +R   LF + L+       R     Y+G+
Sbjct: 442 VGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGR 501

Query: 348 LPTTGMTITKLEDSENH------RNAFEISGSMIERILVSC-NNQQDLQEWVE 393
           L    M +  L D  +       +NAF++     + + + C   Q+D   W++
Sbjct: 502 LDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQ 554


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score =  117 bits (292), Expect = 4e-26
 Identities = 88/312 (28%), Positives = 152/312 (48%), Gaps = 18/312 (5%)

Query: 93  YYNVVLQNILETENEYSKELQTVLSTYLRPL--QTSEKLSSANISYLMGNLEEICSFQQM 150
           Y + V+Q ILETE  Y ++L++++  YL  +  QT   L +   S L GN+++I  F   
Sbjct: 113 YVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSE 172

Query: 151 LVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFM 208
           L+Q LE C   P A   +  CF++   +   +Y  YC N+P +V VLTE   ++ L +F 
Sbjct: 173 LLQDLENCENDPVA---IAECFVSKSEEFH-IYTQYCTNYPRSVAVLTECMRNKILAKFF 228

Query: 209 ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSA 268
             +  +    L L + L KP  R+ KY  LL E+E H++        +  ++   + ++ 
Sbjct: 229 RERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAW 288

Query: 269 QCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLF 326
              +++++ E  + LQ +   + NW+G D+ + G +       IQ A    KNER L LF
Sbjct: 289 HINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRA----KNERTLFLF 344

Query: 327 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSEN-HRNAFEISGSMIERILVSCNNQ 385
             +LL+     R   F Y+  +    + + ++   E    + F      ++   V   +Q
Sbjct: 345 DKLLLI--TKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQH-TVQAKSQ 401

Query: 386 QDLQEWVEHLQK 397
           QD + WV HL++
Sbjct: 402 QDKRLWVLHLKR 413


>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
          Length = 516

 Score =  109 bits (273), Expect = 7e-24
 Identities = 96/405 (23%), Positives = 170/405 (41%), Gaps = 31/405 (7%)

Query: 24  ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR-----EVKASEKPVSPKSGTLK 78
           EL+F  GDVI V       WW G ++   GWFP+++VR     E +  E P   ++G L 
Sbjct: 26  ELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHL- 84

Query: 79  SPPKGFDTTAINKSYYN------VVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSS 131
                 D   + +   N       V+  I+ TE  Y K L+ +   YL+   +  +  S 
Sbjct: 85  --DPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSD 142

Query: 132 ANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANH 190
             +  + GN+E+I  FQ   V+ LE+     +     +G CFL        +Y  YC NH
Sbjct: 143 EQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYCNNH 201

Query: 191 PSAVNVLTE--HSEELGEFMETKGASSPGILVLTTG-LSKPFMRLDKYPTLLKELERHME 247
             A   L++         F E        I +   G L  P  ++ KYP  L EL ++  
Sbjct: 202 LDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTA 261

Query: 248 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDI-KTLGNVTY 304
             H+D + +  ++A  +N++ Q  E ++R E   ++     ++ +WEG+DI      + Y
Sbjct: 262 QDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIY 321

Query: 305 MSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSEN 363
             ++           +R   LF + +++      R     Y+G++      +  +ED  +
Sbjct: 322 TGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRD 381

Query: 364 H------RNAFEISGSMIERI-LVSCNNQQDLQEWVEHLQKQTKV 401
                  +NAF++     E I L      ++   W+   +++ K+
Sbjct: 382 DDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKM 426


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score =  106 bits (264), Expect = 8e-23
 Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)

Query: 11   VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 70
            V A +++   NEDELSFSKG +I+V   ++  WW+G +NG TG FPSNYV+    S+ P 
Sbjct: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1163

Query: 71   SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 130
                  L++     DT    +      +  +++TE  Y  +LQ V+  + + +  S  L+
Sbjct: 1164 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1219

Query: 131  SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 187
               ++ +  N +E+      L+++L    K    +   Q +G      +  M+  Y+ +C
Sbjct: 1220 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1278

Query: 188  ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 243
            +   +   +L + ++E  +F E   K AS P    + L++ L KP  R+ +YP L++ + 
Sbjct: 1279 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1338

Query: 244  RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 278
             +  + H D   ++ ++   + L +Q  E  + KE
Sbjct: 1339 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1373



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)

Query: 12  RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 67
           RA + F+  N DE+SF+ GD+I V    V E GW  G+  G  GWFP NYV ++ +S  E
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795

Query: 68  KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 101
           K VSPK   L            S P   +  A    Y NV   N+
Sbjct: 796 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)

Query: 13   AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 72
            A + +      +L+F++G+ I VT+ ++G WW G++  R+G FPSNYV+         + 
Sbjct: 961  ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1019

Query: 73   KSGTLKSPPK 82
            KSG     P+
Sbjct: 1020 KSGASNKKPE 1029



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)

Query: 9   LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 67
           L  +A  ++    ++ L+FSK D+I V   +E  WW G ++G  GWFP +YV+ +  SE
Sbjct: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 931


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score =  106 bits (264), Expect = 8e-23
 Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)

Query: 11   VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 70
            V A +++   NEDELSFSKG +I+V   ++  WW+G +NG TG FPSNYV+    S+ P 
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1190

Query: 71   SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 130
                  L++     DT    +      +  +++TE  Y  +LQ V+  + + +  S  L+
Sbjct: 1191 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1246

Query: 131  SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 187
               ++ +  N +E+      L+++L    K    +   Q +G      +  M+  Y+ +C
Sbjct: 1247 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1305

Query: 188  ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 243
            +   +   +L + ++E  +F E   K AS P    + L++ L KP  R+ +YP L++ + 
Sbjct: 1306 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1365

Query: 244  RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 278
             +  + H D   ++ ++   + L +Q  E  + KE
Sbjct: 1366 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1400



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)

Query: 12  RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 67
           RA + F+  N DE+SF+ GD+I V    V E GW  G+  G  GWFP NYV ++ +S  E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822

Query: 68  KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 101
           K VSPK   L            S P   +  A    Y NV   N+
Sbjct: 823 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 867



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)

Query: 13   AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 72
            A + +      +L+F++G+ I VT+ ++G WW G++  R+G FPSNYV+         + 
Sbjct: 988  ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1046

Query: 73   KSGTLKSPPK 82
            KSG     P+
Sbjct: 1047 KSGASNKKPE 1056



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)

Query: 9   LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 67
           L  +A  ++    ++ L+FSK D+I V   +E  WW G ++G  GWFP +YV+ +  SE
Sbjct: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 958


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score =  103 bits (256), Expect = 6e-22
 Identities = 66/271 (24%), Positives = 131/271 (48%), Gaps = 13/271 (4%)

Query: 15   FNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKS 74
            +++   N+DEL+F+KG +I+V   E+  WW+G +NG+ G FPSNYV+ +     P     
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK-LTTDMDPSQQWC 1222

Query: 75   GTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI 134
              L        T    + Y    +  ++ TE  Y  +LQ V   + +PL  SE L+   +
Sbjct: 1223 SDLHLLDMLTPTERKRQGY----IHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEV 1278

Query: 135  SYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYCANHP 191
            + +  N +E+      L+++L    K+   +   + +G      +P M+  Y+ +C+   
Sbjct: 1279 AMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQP-YIRFCSRQL 1337

Query: 192  SAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELERHME 247
            +   ++ + ++E  +F E   + A  P    + L++ + KP  R+ +YP ++K +  +  
Sbjct: 1338 NGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTP 1397

Query: 248  DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 278
            + H D   ++ ++   + L +Q  E  + KE
Sbjct: 1398 ENHPDHSHLKHALEKAEELCSQVNEGVREKE 1428



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 26/70 (37%), Positives = 44/70 (62%), Gaps = 1/70 (1%)

Query: 13   AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 72
            A + ++ + + +L+F +GDVI VT+ ++G WW GT+  + G FPSNYVR   +     + 
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTK-KDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067

Query: 73   KSGTLKSPPK 82
            K+G+L   P+
Sbjct: 1068 KTGSLGKKPE 1077



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 26/78 (33%), Positives = 43/78 (55%), Gaps = 9/78 (11%)

Query: 12  RAKFNFQQTNEDELSFSKGDVIHV-------TRVEEGGWWEGTLNGRTGWFPSNYVREVK 64
           RA + F+  + DE++   GD++ V       ++  E GW  G L G+TGWFP+NY  ++ 
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805

Query: 65  ASE--KPVSPKSGTLKSP 80
            +E   PV P + +  +P
Sbjct: 806 ENEVPAPVKPVTDSTSAP 823



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 12/92 (13%)

Query: 16   NFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGR-----TGWFPSNYVREVKASEKPV 70
            ++  T  ++L+ + G +I + +   GGWWEG L  R      GWFP+NYV+ +      +
Sbjct: 1084 SYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKI 1143

Query: 71   SPKSGTLKSPPKGFDTTAINK--SYYNVVLQN 100
            +P       PPK     A+ +    Y+   QN
Sbjct: 1144 TP-----TEPPKSTALAAVCQVIGMYDYTAQN 1170



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 25/73 (34%), Positives = 42/73 (57%), Gaps = 2/73 (2%)

Query: 9   LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKAS-E 67
           L  +A + ++   ++ L+F+K DVI V   ++  WW G + G+ GWFP +YV+ +     
Sbjct: 916 LQAQALYPWRAKKDNHLNFNKNDVITVLE-QQDMWWFGEVQGQKGWFPKSYVKLISGPIR 974

Query: 68  KPVSPKSGTLKSP 80
           K  S  SG+ +SP
Sbjct: 975 KSTSMDSGSSESP 987


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 33/306 (10%)

Query: 97  VLQNILETENEYSKELQTVLSTYLRPLQTS------EKLSSANISYLMGNLEEICSFQQM 150
           VL  IL TE +Y   L+ + S +L  ++ +      + L+  N+  L  N+E+I    + 
Sbjct: 53  VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112

Query: 151 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 207
            + +LE C    P++Q  +G  FL    +   +Y  YC+NH  A+ +L E ++   +  F
Sbjct: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKF-CVYEEYCSNHEKALRLLVELNKIPTVRAF 171

Query: 208 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 264
           + +    G      + L   L  P  R+ KYP LLKEL +     H D   +Q ++ A K
Sbjct: 172 LLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMK 231

Query: 265 NLSAQCQEVRKRKE-LE-LQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERY 322
            + +   E +++ E LE L+ L   I  WEG ++  +     +   L++ +    + ER 
Sbjct: 232 TVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQ-ERA 290

Query: 323 LLLFPNVLLMLSASPRMSG---------------FIYQGKLPTTGMTITKLED--SENHR 365
             LF N+L+      R++G               +I++G++ T  M +  +ED  ++ H 
Sbjct: 291 FFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHS 350

Query: 366 NAFEIS 371
           N + ++
Sbjct: 351 NGYTVT 356


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 84/336 (25%), Positives = 154/336 (45%), Gaps = 37/336 (11%)

Query: 97  VLQNILETENEYSKELQTVLSTYLRPL------QTSEKLSSANISYLMGNLEEICSFQQM 150
           VL  + +TE +Y   L+ ++S +L  +      +  + ++   +  L  N+E+I +  + 
Sbjct: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86

Query: 151 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 207
            ++ +EEC    P AQQ VG CFL+   + + +Y  YC+NH  A  +L E ++   +  F
Sbjct: 87  FLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLELNKIRTIRTF 145

Query: 208 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 264
           +      G      + L   L  P  R+ KYP +LKEL +     H+D   + +++ A K
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205

Query: 265 NLSAQCQEVRKRKELELQILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNER 321
            + +   E +++ E +L++L E    I  WEG +I        M  VL++ + S    ER
Sbjct: 206 AVCSNINEAKRQME-KLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS-SGNIQER 263

Query: 322 YLLLFPNVLLML----------SASPRMSGFIYQGKLPTTGMTITKLED------SENH- 364
              LF N+L+             AS     ++++G++ T  M +  ++D      S  H 
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHI 323

Query: 365 -RNAFEISGSMIERILV-SCNNQQDLQEWVEHLQKQ 398
             N ++I  +   +  V      ++  EW E + K+
Sbjct: 324 VVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 84/336 (25%), Positives = 154/336 (45%), Gaps = 37/336 (11%)

Query: 97  VLQNILETENEYSKELQTVLSTYLRPL------QTSEKLSSANISYLMGNLEEICSFQQM 150
           VL  + +TE +Y   L+ ++S +L  +      +  + ++   +  L  N+E+I +  + 
Sbjct: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86

Query: 151 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 207
            ++ +EEC    P AQQ VG CFL+   + + +Y  YC+NH  A  +L E ++   +  F
Sbjct: 87  FLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLELNKIRTIRTF 145

Query: 208 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 264
           +      G      + L   L  P  R+ KYP +LKEL +     H+D   + +++ A K
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205

Query: 265 NLSAQCQEVRKRKELELQILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNER 321
            + +   E +++ E +L++L E    I  WEG +I        M  VL++ + S    ER
Sbjct: 206 AVCSNINEAKRQME-KLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS-SGNIQER 263

Query: 322 YLLLFPNVLLML----------SASPRMSGFIYQGKLPTTGMTITKLED------SENH- 364
              LF N+L+             AS     ++++G++ T  M +  ++D      S  H 
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHI 323

Query: 365 -RNAFEISGSMIERILV-SCNNQQDLQEWVEHLQKQ 398
             N ++I  +   +  V      ++  EW E + K+
Sbjct: 324 VVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359


>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
           [Homo sapiens]
          Length = 1045

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 87/373 (23%), Positives = 150/373 (40%), Gaps = 20/373 (5%)

Query: 90  NKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQ 149
           +K+Y+  + + +  TE  Y K+L+ + S +   +   + +  A  S +  N E +  F  
Sbjct: 539 DKAYF--IAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHT 596

Query: 150 MLVQSLEECTKLPEAQ--------QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVL---T 198
             ++ +E+   L E +        QR+G   L  +  MK L   +   H  A+  L    
Sbjct: 597 NFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHL-AAHLWKHSEALEALENGI 655

Query: 199 EHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQK 258
           + S  L  F           L L T L +P  RL  Y  +L+ L +H    H D +D + 
Sbjct: 656 KSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRA 715

Query: 259 SMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEK 318
           ++A    + AQ      + E   Q L E  ++  G D   +    ++    +     +  
Sbjct: 716 ALAEITEMVAQLHGTMIKME-NFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGL 774

Query: 319 NERYLLLFPNVLLMLSASPRMSG-FIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIER 377
            +R   LF +VLL  S     S  F   G+LP  GMTI + ED     +   + G   + 
Sbjct: 775 QQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQR-QS 833

Query: 378 ILVSCNNQQDLQEWVEHLQKQ---TKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 434
           I+V+ +++ ++++WVE +Q      + +S   P     S P +  P        +  D  
Sbjct: 834 IIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDL 893

Query: 435 PAPLTPAYHTLPH 447
            A  T      PH
Sbjct: 894 SASRTSLERQAPH 906


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 76/313 (24%), Positives = 145/313 (46%), Gaps = 22/313 (7%)

Query: 97  VLQNILETENEYSKELQTVLSTYLRPLQTSEKL--SSANISYLMGNLEEICSFQQMLVQS 154
           V + I+ETE  Y ++L++++  YL PL     L  S   +  L  N+E+I  F   L++ 
Sbjct: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLED 165

Query: 155 LEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFMETKG 212
           LE  +    +   +  CF+        +Y  YC N+PS++ +L E   S     +++ + 
Sbjct: 166 LENSS----SAGGIAECFVQRSEDFD-IYTLYCMNYPSSLALLRELSLSPPAALWLQERQ 220

Query: 213 ASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMED--YHTDRQDIQKSMAAFKNLSAQC 270
           A     L L + L KP  R+ KY  LL+EL +H  +      R+ +++++ +   ++   
Sbjct: 221 AQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYI 280

Query: 271 QEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSE--EKNERYLLLF 326
            ++++++E    LQ +   +  W G ++   G +           G       ER L LF
Sbjct: 281 NDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLF 340

Query: 327 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMI--ERILVSCNN 384
             +LL+  A  R   + Y+G +    ++++   +S      F++S   I   R L+   N
Sbjct: 341 SRMLLV--AKRRGLEYTYKGHIFCCNLSVS---ESPRDPLGFKVSDLTIPKHRHLLQAKN 395

Query: 385 QQDLQEWVEHLQK 397
           Q++ + W+  LQ+
Sbjct: 396 QEEKRLWIHCLQR 408


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 80/348 (22%), Positives = 152/348 (43%), Gaps = 16/348 (4%)

Query: 62  EVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLST-YL 120
           E K  E+        L+   +  +    N+   + +   +L TE  Y   L  +    Y 
Sbjct: 175 ETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYC 234

Query: 121 RPLQTSEKLS--SANISYLMGNLEEICSFQ-QMLVQSLEECTKLPEAQQRVGGCFLNLMP 177
           + L+ + + S  +  ++ +  N+  I +F  + L+  LE+  +  E   R+G     L P
Sbjct: 235 KLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAP 294

Query: 178 QMKTLYLTYCANHPSAVNVLTEHSEELGEFM----ETKGASSPGILVLTTGLSKPFMRLD 233
            +K +Y  Y     +A+ ++   +E + +F     E +     G L L   + +P  R+ 
Sbjct: 295 FLK-MYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIP 353

Query: 234 KYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQE-VRKRKELELQILTEAIRNWE 292
           +Y  LLK+  R +     D  D +KS+      ++     +RK + L+  +    +   E
Sbjct: 354 RYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEE 413

Query: 293 GDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSG--FIYQGKLPT 350
            D +     +    Q+L   A +    ERYL LF N+LL       + G  F  + ++  
Sbjct: 414 EDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGI 473

Query: 351 TGMTITKLEDSENHRNAFEISGSMIERIL-VSCNNQQDLQEWVEHLQK 397
            GM I + + +E + + F++SG   ER L +  ++ QD +EW++ LQ+
Sbjct: 474 DGMKIVETQ-NEEYPHTFQVSGK--ERTLELQASSAQDKEEWIKALQE 518


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
           sapiens]
          Length = 1054

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 77/340 (22%), Positives = 145/340 (42%), Gaps = 18/340 (5%)

Query: 97  VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 156
           +++ IL TE  Y K+L+ +   +   +   + + +  ++ L  N++ I  F +  ++ +E
Sbjct: 539 IVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVE 598

Query: 157 ECTKLPE---------AQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVL---TEHSEEL 204
           +   L E         + QR+G   L  M Q+K  + +Y   H   +  L   T+  ++L
Sbjct: 599 QRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKE-FTSYFQRHDEVLTELEKATKRCKKL 657

Query: 205 GEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 264
               +         L L T L KP  RL  Y  LL+ L  H    H D  D   ++ A  
Sbjct: 658 EAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAIT 717

Query: 265 NLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLL 324
            ++   Q +  R E  LQ LTE  R+  G +        ++ +  +     +   +R   
Sbjct: 718 EVTTTLQHILIRLE-NLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFF 776

Query: 325 LFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN 383
           LF ++LL  S      S F  +G LP  GM + + ++  +  + F I  +  + I+V+ +
Sbjct: 777 LFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQ-KTIVVAAS 835

Query: 384 NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHP 423
            + + ++W+  L    +    G  T    ++P  T+ + P
Sbjct: 836 TRLEKEKWMLDLNSAIQAAKSGGDTAP--ALPGRTVCTRP 873


>gi|45439359 triple functional domain (PTPRF interacting) [Homo
            sapiens]
          Length = 3097

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 75/322 (23%), Positives = 154/322 (47%), Gaps = 50/322 (15%)

Query: 97   VLQNILETENEYSKELQTVLSTYLRPLQTS-EKLSSANIS---YLMGNLEEICSFQQ-ML 151
            ++  +++TE  Y ++L+  + TYL  + +  E++    ++    + GN++EI  F   + 
Sbjct: 1296 IMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIF 1355

Query: 152  VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHS-EELGEFMET 210
            ++ LE+  +LPE    VG CF+    + + +Y+TYC N P +  ++ EH+     E  + 
Sbjct: 1356 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSTQLILEHAGSYFDEIQQR 1411

Query: 211  KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAA-------- 262
             G ++     +++ L KP  R+ KY  LLKEL    E+   + +D  + M +        
Sbjct: 1412 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDA 1467

Query: 263  --FKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNE 320
                 L    + +  + EL   IL E+ + W   D KTL                 +  E
Sbjct: 1468 MHLSMLEGFDENIESQGEL---ILQESFQVW---DPKTL---------------IRKGRE 1506

Query: 321  RYLLLFPNVLLM---LSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEI--SGSMI 375
            R+L LF   L+    +  S   S ++Y+ KL T+ + +T+  + +  + A  +  + +  
Sbjct: 1507 RHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSD 1566

Query: 376  ERILVSCNNQQDLQEWVEHLQK 397
             +I++  ++ ++ Q+W++H+++
Sbjct: 1567 NKIVLKASSIENKQDWIKHIRE 1588



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 75/361 (20%), Positives = 161/361 (44%), Gaps = 38/361 (10%)

Query: 56   PSNYVREVKASEKP-VSPKSGTLKSPPKGFD------TTAINKSYYNVVLQNILETENEY 108
            PS+ + +   S  P  +P   +L S     D      ++++ + +Y  VLQ ++ETE +Y
Sbjct: 1927 PSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHY--VLQELVETERDY 1984

Query: 109  SKELQTVLSTYLRPLQTSEKLSS--ANISYLMGNLEEICSFQQ-MLVQSLEECTKLPEAQ 165
             ++L  V+  Y+  ++              + GN+ +I  + +   +  LE+C + PE  
Sbjct: 1985 VRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPE-- 2042

Query: 166  QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGL 225
             ++G  F+    ++  +Y+ YC N P + ++++E+ +   E ++ +       L LT  L
Sbjct: 2043 -KLGSLFVKHERRLH-MYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHR---LQLTDLL 2097

Query: 226  SKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILT 285
             KP  R+ KY  LLK+  ++ +    D  ++++++     +  +C ++     L+     
Sbjct: 2098 IKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQ----- 2152

Query: 286  EAIRNWEGDDIKTLGNVTYMSQVLI--QCAGSEEK-NERYLLLFPNVLLMLSASPRMSGF 342
                 ++G  I   G +      L+  Q AG   +  ER + LF  +++      +  GF
Sbjct: 2153 ----GFDG-KIVAQGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGF 2207

Query: 343  IYQGKLPTTGMTITKL---EDSENHRNAFEI---SGSMIERILVSCNNQQDLQEWVEHLQ 396
               G L    + ++ L   E+ EN    F +   +G ++E  ++  ++    Q W+  + 
Sbjct: 2208 SMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEIN 2267

Query: 397  K 397
            +
Sbjct: 2268 Q 2268


>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
          Length = 2986

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 82/358 (22%), Positives = 160/358 (44%), Gaps = 54/358 (15%)

Query: 97   VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI----SYLMGNLEEICSFQQ-ML 151
            ++  +L+TE  Y ++L   L TYL  + +  +     I      + GN++EI  F   + 
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344

Query: 152  VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE-LGEFMET 210
            ++ LE+  +LPE    VG CF+    + + +Y+TYC N P +  ++ EH+     E  + 
Sbjct: 1345 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSNQLILEHAGTFFDEIQQR 1400

Query: 211  KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC 270
             G ++     +++ L KP  R+ KY  LLKEL    E+   + +D  + M +    +   
Sbjct: 1401 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDA 1456

Query: 271  QEVRK----RKELELQ---ILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 323
              V       + L++Q   IL +A + W+   +   G                   ER+L
Sbjct: 1457 MHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------------RERHL 1498

Query: 324  LLFPNVLLMLSASPRMSG---FIYQGKLPTTGMTITKLEDSENHRNAF--EISGSMIERI 378
             LF   L+        SG   ++Y+ KL T+ + +T+  + +  + A     + S   + 
Sbjct: 1499 FLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKT 1558

Query: 379  LVSCNNQQDLQEWVEHLQK--QTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 434
            ++  +N +  QEW++++++  Q ++  +     +P  +P         TP+ +  +SK
Sbjct: 1559 VLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPK--------TPAKQRNNSK 1608



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 86/403 (21%), Positives = 171/403 (42%), Gaps = 52/403 (12%)

Query: 97   VLQNILETENEYSKELQTVLSTYLRPLQTS---EKLSSANISYLMGNLEEICSFQQ-MLV 152
            VL  +++TE +Y K+L  V+  +++ ++     E +   +   + GN+ +I  + +   +
Sbjct: 1933 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKD-KIVFGNIHQIYDWHKDFFL 1991

Query: 153  QSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKG 212
              LE+C    + Q R+   F+    ++  +Y+ YC N P +  ++ E+     E  +   
Sbjct: 1992 AELEKCI---QEQDRLAQLFIKHERKLH-IYVWYCQNKPRSEYIVAEYDAYFEEVKQEIN 2047

Query: 213  ASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQE 272
                  L L+  L KP  R+ KY  LLK+  R+ E    +  DI+K++     +  +C +
Sbjct: 2048 QR----LTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCND 2103

Query: 273  VRKRKELELQILTEAIRNWEGD---DIKTLGNVTYMSQVLIQCAGSEEK-NERYLLLFPN 328
            +     L+          +EG      K L   T+   V+   AG + +  ER + LF  
Sbjct: 2104 MMNLGRLQ---------GFEGTLTAQGKLLQQDTF--YVIELDAGMQSRTKERRVFLFEQ 2152

Query: 329  VLL---MLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQ 385
            +++   +L       G++++  +    + + +  D++  + A  ++    ER+++   N 
Sbjct: 2153 IVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL-MNRETSERVVLQAANA 2211

Query: 386  QDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTL 445
               Q WV+ +          N  ++      + L S P+    K   +      PA   L
Sbjct: 2212 DIQQAWVQDI----------NQVLETQRDFLNALQS-PIEYQRKERSTAVMRSQPA--RL 2258

Query: 446  PHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAA 488
            P  S    P++++  G  +PPK       S   P PPL+ S +
Sbjct: 2259 PQASPR--PYSSVPAGSEKPPK-----GSSYNPPLPPLKISTS 2294


>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
          Length = 1663

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 82/358 (22%), Positives = 160/358 (44%), Gaps = 54/358 (15%)

Query: 97   VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI----SYLMGNLEEICSFQQ-ML 151
            ++  +L+TE  Y ++L   L TYL  + +  +     I      + GN++EI  F   + 
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344

Query: 152  VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE-LGEFMET 210
            ++ LE+  +LPE    VG CF+    + + +Y+TYC N P +  ++ EH+     E  + 
Sbjct: 1345 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSNQLILEHAGTFFDEIQQR 1400

Query: 211  KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC 270
             G ++     +++ L KP  R+ KY  LLKEL    E+   + +D  + M +    +   
Sbjct: 1401 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDA 1456

Query: 271  QEVRK----RKELELQ---ILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 323
              V       + L++Q   IL +A + W+   +   G                   ER+L
Sbjct: 1457 MHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------------RERHL 1498

Query: 324  LLFPNVLLMLSASPRMSG---FIYQGKLPTTGMTITKLEDSENHRNAF--EISGSMIERI 378
             LF   L+        SG   ++Y+ KL T+ + +T+  + +  + A     + S   + 
Sbjct: 1499 FLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKT 1558

Query: 379  LVSCNNQQDLQEWVEHLQK--QTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 434
            ++  +N +  QEW++++++  Q ++  +     +P  +P         TP+ +  +SK
Sbjct: 1559 VLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPK--------TPAKQRNNSK 1608


>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
          Length = 1591

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 60/213 (28%), Positives = 95/213 (44%), Gaps = 23/213 (10%)

Query: 60   VREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTY 119
            + E+  S++  SP+  T   P         +      V+  +LETE  Y K+L  ++  Y
Sbjct: 1009 LHEMNPSDQSPSPQDST--GPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERY 1066

Query: 120  LRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKL-PEAQQ------------ 166
            L+PLQ    L+   +  L GNL E+  FQ   +++LE+  +L P+ ++            
Sbjct: 1067 LKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLF 1126

Query: 167  RVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELG--EFMETKGASSPGILVLTTG 224
             +GG FL    + K LY  +CA+H     VL +   +     F++ +         L + 
Sbjct: 1127 SLGGSFLYYADRFK-LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESY 1185

Query: 225  LSKPFMRLDKYPTLLKEL-----ERHMEDYHTD 252
            L KP  R+ KYP LL+EL         E YH D
Sbjct: 1186 LIKPIQRILKYPLLLRELFALTDAESEEHYHLD 1218


>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
           [Homo sapiens]
          Length = 626

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)

Query: 80  PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 139
           PP+       +      V+Q +++TE  Y K+L  +   YL PLQ    L+   +  L G
Sbjct: 11  PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 70

Query: 140 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 186
           +L E+  FQ++ +++LE+           + P   ++    +GG FL      K LY  +
Sbjct: 71  SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 129

Query: 187 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 244
           CANH     VL   +  +    F++ +  +      L + L KP  R+ KYP LLKEL  
Sbjct: 130 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 189

Query: 245 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 275
             +    +   + +++ A + +++   E++K
Sbjct: 190 LTDQESEEHYHLTEALKAMEKVASHINEMQK 220


>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
            sapiens]
          Length = 1701

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)

Query: 80   PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 139
            PP+       +      V+Q +++TE  Y K+L  +   YL PLQ    L+   +  L G
Sbjct: 1086 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 1145

Query: 140  NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 186
            +L E+  FQ++ +++LE+           + P   ++    +GG FL      K LY  +
Sbjct: 1146 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 1204

Query: 187  CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 244
            CANH     VL   +  +    F++ +  +      L + L KP  R+ KYP LLKEL  
Sbjct: 1205 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 1264

Query: 245  HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 275
              +    +   + +++ A + +++   E++K
Sbjct: 1265 LTDQESEEHYHLTEALKAMEKVASHINEMQK 1295


>gi|39930351 dynamin binding protein [Homo sapiens]
          Length = 1577

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 48/197 (24%), Positives = 96/197 (48%), Gaps = 19/197 (9%)

Query: 97  VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 156
           V++ +L+TE +Y ++L+  +   + P+Q ++ + + +   L GN++ +    + L+ +LE
Sbjct: 788 VIEELLQTERDYIRDLEMCIERIMVPMQQAQ-VPNIDFEGLFGNMQMVIKVSKQLLAALE 846

Query: 157 ECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLT--EHSEELGEFMETKGAS 214
                      VG  FL    +++  Y  YC NH  A+ +L   E  E++ + ++   A 
Sbjct: 847 -------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLAD 899

Query: 215 SPGI---------LVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKN 265
              +         + L + L KP  R+ +YP LL EL     + H D+  +  ++ A K 
Sbjct: 900 LKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKE 959

Query: 266 LSAQCQEVRKRKELELQ 282
           ++    E ++RK+L L+
Sbjct: 960 INVNINEYKRRKDLVLK 976



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 27/73 (36%), Positives = 38/73 (52%), Gaps = 3/73 (4%)

Query: 13  AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR---EVKASEKP 69
           A + FQ    +EL F  GD I +    E GW EG+L GRTG FP  +V+   + +  E  
Sbjct: 250 ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETM 309

Query: 70  VSPKSGTLKSPPK 82
             P+ G+L   P+
Sbjct: 310 ALPQEGSLARIPE 322



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 22/49 (44%), Positives = 28/49 (57%)

Query: 12  RAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
           RA        ++EL F +GDVI +  V E GW+EG L GR G FP  +V
Sbjct: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFV 199



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 17/56 (30%), Positives = 30/56 (53%), Gaps = 4/56 (7%)

Query: 13   AKFNFQQTNEDELSFSKGDVIHVTRVEE----GGWWEGTLNGRTGWFPSNYVREVK 64
            A + F+  N +ELS S    + +   ++      WW   +NG+ G+ PSNY+R+ +
Sbjct: 1520 AVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIRKTE 1575



 Score = 38.1 bits (87), Expect = 0.025
 Identities = 22/54 (40%), Positives = 29/54 (53%)

Query: 10 VVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 63
          VVRA F+F  +  +EL    GD+I V  V +  W  G     TG FPS++V  V
Sbjct: 6  VVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIV 59



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 17/53 (32%), Positives = 28/53 (52%), Gaps = 1/53 (1%)

Query: 17  FQQTNEDELSFSKGDVIHVTRVEEGGWWEG-TLNGRTGWFPSNYVREVKASEK 68
           F     D L   +GD++ +  +   GW +G +  G  G+FPS+ VRE+  S +
Sbjct: 77  FTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQ 129


>gi|55749621 pleckstrin homology domain containing, family G, member
           3 [Homo sapiens]
          Length = 1163

 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 59/270 (21%), Positives = 116/270 (42%), Gaps = 31/270 (11%)

Query: 134 ISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSA 193
           +SYL   + EI   ++M VQ L    +  E                  +Y  YC N+P++
Sbjct: 91  LSYLGRVVREIVETERMYVQDLRSIVESQEFD----------------IYTQYCNNYPNS 134

Query: 194 VNVLTE--HSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHT 251
           V  LTE    ++  +F   +       L L + L KP  R+ KY  LL+E+ +H ++   
Sbjct: 135 VAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEED 194

Query: 252 DRQDIQKSMAAFKNLSAQCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVL 309
             + ++ ++     ++    ++++R E  + LQ +   + NW+G D+ T G +       
Sbjct: 195 GFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEGTFR 254

Query: 310 IQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFE 369
           +       +NER   LF   LL+     R   F+Y+G +P + +    L +S      F 
Sbjct: 255 VH----RVRNERTFFLFDKTLLI--TKKRGDHFVYKGNIPCSSL---MLIESTRDSLCFT 305

Query: 370 IS--GSMIERILVSCNNQQDLQEWVEHLQK 397
           ++      ++  +     ++ + W  H+++
Sbjct: 306 VTHYKHSKQQYSIQAKTVEEKRNWTHHIKR 335


>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
           sapiens]
          Length = 665

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 45/132 (34%), Positives = 68/132 (51%), Gaps = 7/132 (5%)

Query: 14  KFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPK 73
           +F++Q  ++DEL+ S G++I   R E+GGWWEG +NGR G FP N+VRE+K   K +   
Sbjct: 7   EFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIK---KEMKKD 63

Query: 74  SGTLKSPPKGFDTTAINKSYYNVVLQNILET--ENEYSKELQTVLSTYLRPLQTSEKLSS 131
             T K+P K         S  +   + IL T    E  +    V  +YL       +L  
Sbjct: 64  PLTNKAPEKPLHEVPSGNSLLS--SETILRTNKRGERRRRRCQVAFSYLPQNDDELELKV 121

Query: 132 ANISYLMGNLEE 143
            +I  ++G +EE
Sbjct: 122 GDIIEVVGEVEE 133



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 25/49 (51%), Positives = 34/49 (69%)

Query: 15  FNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 63
           F++   N+DEL    GD+I V    E GWWEG LNG+TG FPSN+++E+
Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 155



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 30/94 (31%), Positives = 48/94 (51%), Gaps = 18/94 (19%)

Query: 3   DNSNNQLVVRAK--------FNFQQTNEDELSFSKGDVIHVTRVE--EGGWWEGTLNGRT 52
           D+S  ++  R K        F ++  N+DEL+  +GD++ +   +  + GWWEG LNGR 
Sbjct: 256 DSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR 315

Query: 53  GWFPSNYV--------REVKASEKPVSPKSGTLK 78
           G FP N+V        +E    +KP  P +  +K
Sbjct: 316 GVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIK 349


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.128    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,190,585
Number of Sequences: 37866
Number of extensions: 1378056
Number of successful extensions: 9163
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 298
Number of HSP's successfully gapped in prelim test: 619
Number of HSP's that attempted gapping in prelim test: 6930
Number of HSP's gapped (non-prelim): 2571
length of query: 646
length of database: 18,247,518
effective HSP length: 109
effective length of query: 537
effective length of database: 14,120,124
effective search space: 7582506588
effective search space used: 7582506588
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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