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Search of human proteins with 166064034
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166064034 PAK-interacting exchange factor beta isoform c
[Homo sapiens]
(803 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 1621 0.0
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo... 1568 0.0
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 1498 0.0
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 1125 0.0
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ... 1125 0.0
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 816 0.0
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 136 9e-32
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 135 1e-31
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 124 5e-28
gi|71274148 pleckstrin homology domain containing, family G (wit... 117 6e-26
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 109 9e-24
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 106 1e-22
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 106 1e-22
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 103 8e-22
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 99 2e-20
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 96 2e-19
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 96 2e-19
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 87 8e-17
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 86 2e-16
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 79 1e-14
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 79 2e-14
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 79 2e-14
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 78 3e-14
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 78 3e-14
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 78 3e-14
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 78 3e-14
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 78 3e-14
gi|39930351 dynamin binding protein [Homo sapiens] 74 4e-13
gi|55749621 pleckstrin homology domain containing, family G, mem... 73 9e-13
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 72 3e-12
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 1621 bits (4198), Expect = 0.0
Identities = 803/803 (100%), Positives = 803/803 (100%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP
Sbjct: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
Query: 61 RSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNK 120
RSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNK
Sbjct: 61 RSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNK 120
Query: 121 VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT 180
VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT
Sbjct: 121 VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT 180
Query: 181 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 240
DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE
Sbjct: 181 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 240
Query: 241 VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP 300
VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP
Sbjct: 241 VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP 300
Query: 301 LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL 360
LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL
Sbjct: 301 LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL 360
Query: 361 YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL 420
YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL
Sbjct: 361 YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL 420
Query: 421 ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV 480
ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV
Sbjct: 421 ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV 480
Query: 481 TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE 540
TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE
Sbjct: 481 TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE 540
Query: 541 NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH 600
NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH
Sbjct: 541 NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH 600
Query: 601 PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP 660
PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP
Sbjct: 601 PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP 660
Query: 661 LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY 720
LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY
Sbjct: 661 LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY 720
Query: 721 CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW 780
CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW
Sbjct: 721 CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW 780
Query: 781 TAHSYRMGSTSRKSCCSYISHQN 803
TAHSYRMGSTSRKSCCSYISHQN
Sbjct: 781 TAHSYRMGSTSRKSCCSYISHQN 803
>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
sapiens]
Length = 782
Score = 1568 bits (4060), Expect = 0.0
Identities = 782/803 (97%), Positives = 782/803 (97%), Gaps = 21/803 (2%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP
Sbjct: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
Query: 61 RSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNK 120
RSESECLSNIREFLRGCGASLRLE TFDANDLYQGQNFNK
Sbjct: 61 RSESECLSNIREFLRGCGASLRLE---------------------TFDANDLYQGQNFNK 99
Query: 121 VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT 180
VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT
Sbjct: 100 VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT 159
Query: 181 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 240
DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE
Sbjct: 160 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 219
Query: 241 VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP 300
VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP
Sbjct: 220 VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP 279
Query: 301 LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL 360
LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL
Sbjct: 280 LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL 339
Query: 361 YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL 420
YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL
Sbjct: 340 YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL 399
Query: 421 ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV 480
ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV
Sbjct: 400 ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV 459
Query: 481 TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE 540
TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE
Sbjct: 460 TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE 519
Query: 541 NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH 600
NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH
Sbjct: 520 NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH 579
Query: 601 PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP 660
PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP
Sbjct: 580 PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP 639
Query: 661 LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY 720
LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY
Sbjct: 640 LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY 699
Query: 721 CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW 780
CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW
Sbjct: 700 CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW 759
Query: 781 TAHSYRMGSTSRKSCCSYISHQN 803
TAHSYRMGSTSRKSCCSYISHQN
Sbjct: 760 TAHSYRMGSTSRKSCCSYISHQN 782
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 1498 bits (3879), Expect = 0.0
Identities = 753/803 (93%), Positives = 753/803 (93%), Gaps = 50/803 (6%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEK
Sbjct: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEK----- 55
Query: 61 RSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNK 120
TFDANDLYQGQNFNK
Sbjct: 56 ---------------------------------------------TFDANDLYQGQNFNK 70
Query: 121 VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT 180
VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT
Sbjct: 71 VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT 130
Query: 181 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 240
DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE
Sbjct: 131 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 190
Query: 241 VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP 300
VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP
Sbjct: 191 VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP 250
Query: 301 LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL 360
LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL
Sbjct: 251 LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL 310
Query: 361 YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL 420
YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL
Sbjct: 311 YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL 370
Query: 421 ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV 480
ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV
Sbjct: 371 ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV 430
Query: 481 TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE 540
TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE
Sbjct: 431 TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE 490
Query: 541 NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH 600
NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH
Sbjct: 491 NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH 550
Query: 601 PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP 660
PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP
Sbjct: 551 PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP 610
Query: 661 LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY 720
LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY
Sbjct: 611 LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY 670
Query: 721 CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW 780
CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW
Sbjct: 671 CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW 730
Query: 781 TAHSYRMGSTSRKSCCSYISHQN 803
TAHSYRMGSTSRKSCCSYISHQN
Sbjct: 731 TAHSYRMGSTSRKSCCSYISHQN 753
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 1125 bits (2911), Expect = 0.0
Identities = 554/555 (99%), Positives = 555/555 (100%)
Query: 179 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 238
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
Query: 239 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 298
REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
Query: 299 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 358
RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
Query: 359 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 418
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
Query: 419 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 478
ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
Query: 479 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 538
NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
Query: 539 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 598
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
Query: 599 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 658
SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
Query: 659 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 718
PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
Query: 719 AYCTSAKTRQTLNST 733
AYCTSAKTRQTLNS+
Sbjct: 541 AYCTSAKTRQTLNSS 555
>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 1125 bits (2911), Expect = 0.0
Identities = 554/555 (99%), Positives = 555/555 (100%)
Query: 179 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 238
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
Query: 239 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 298
REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
Query: 299 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 358
RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
Query: 359 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 418
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
Query: 419 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 478
ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
Query: 479 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 538
NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
Query: 539 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 598
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
Query: 599 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 658
SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
Query: 659 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 718
PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
Query: 719 AYCTSAKTRQTLNST 733
AYCTSAKTRQTLNS+
Sbjct: 541 AYCTSAKTRQTLNSS 555
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 816 bits (2109), Expect = 0.0
Identities = 422/735 (57%), Positives = 535/735 (72%), Gaps = 68/735 (9%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
MN EQ VTWLI+LGVLESPKKTI DPE FL++SLK+GVVLC+L+ RL+PG++EK +P
Sbjct: 1 MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP 60
Query: 61 RSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNK 120
++E++C++NI +FL+GC A+L++E+ FD +DLY G NF+K
Sbjct: 61 QTEADCINNINDFLKGC-ATLQVEI---------------------FDPDDLYSGVNFSK 98
Query: 121 VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT 180
VLS+L+ +NK T D S+ C R SS + Q + T Q Q ++++MT
Sbjct: 99 VLSTLLAVNKATED--QLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMT 156
Query: 181 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 240
+N ++QL+V+A+FNF+QTNEDELS KGD+I+VTRVEEGGWWEGTLNGRTGWFPSNYVRE
Sbjct: 157 ENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVRE 216
Query: 241 VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP 300
+K+SE+P+SPK+ KGF+T + K+YY VVLQNIL+TE EY+KELQ++L TYLRP
Sbjct: 217 IKSSERPLSPKA------VKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRP 270
Query: 301 LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL 360
LQ++ LS+ ++ L+GN EE+C+FQQ L Q+LEEC+K PE Q +VGGC L+LMP K++
Sbjct: 271 LQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSM 330
Query: 361 YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL 420
YL YCANHPSAVNVLT+HS+EL +FME +GASSPGIL+LTT LSKPFMRL+KY TLL+EL
Sbjct: 331 YLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQEL 390
Query: 421 ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV 480
ERHMED H D QDI K++ AFK L QCQ++RKRK+LELQIL+E I+ WEG+DIK LGNV
Sbjct: 391 ERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNV 450
Query: 481 TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE 540
+MSQV++Q EEK ERYL+LF NVL+MLSASPRMSGFIYQGK+P G +T+L++ E
Sbjct: 451 IFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIE 510
Query: 541 NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH 600
+ FEI+G+ +ERI+V CNN QD QEW+E L + +
Sbjct: 511 GNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIR---------------------- 548
Query: 601 PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP 660
P+S + SK + + + H+ S G P GPLEPP+ KPWSLSCLRPAPP
Sbjct: 549 --GPASCSSLSKTSSSSCSAHS--SFSSTGQPR-----GPLEPPQIIKPWSLSCLRPAPP 599
Query: 661 LRPSAALCYKE-------DLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQI 713
LRPSAAL YKE + SKSPKTMKK L KRK ERKPS+EE+ RKSTAALEEDAQI
Sbjct: 600 LRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQI 659
Query: 714 LKVIEAYCTSAKTRQ 728
LKVIEAYCTSA +Q
Sbjct: 660 LKVIEAYCTSANFQQ 674
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 136 bits (342), Expect = 9e-32
Identities = 128/542 (23%), Positives = 230/542 (42%), Gaps = 29/542 (5%)
Query: 141 SVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNE 200
+VCA +D L S S H + G+ +++ + + + A ++ ++
Sbjct: 152 AVCADEVGSEEDLYDDLHSSS-HHYSHPGGGGEQLAINELISDGSVVCAEALWDHVTMDD 210
Query: 201 DELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTLKS 257
EL F GDVI V WW G + GWFP+++VR ++P +P +G +
Sbjct: 211 QELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGA 270
Query: 258 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISYLM 316
G + + V+ IL TE +Y K L+ + Y+R + ++ S + +
Sbjct: 271 EDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIF 330
Query: 317 GNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA---V 372
GN+E+I Q+ V++LE+ +G CFL + +Y YC NHP+A +
Sbjct: 331 GNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACVEL 389
Query: 373 NVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQ 432
+ LT+ S+ + F + + L L P ++ KYP L EL ++ H D +
Sbjct: 390 SRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFK 449
Query: 433 DIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQC 490
D++ ++ A KN++ E ++R E ++ +I +WEG+D+ + S L +
Sbjct: 450 DVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRV 509
Query: 491 AGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH------ 542
+ K+ +R LF + L+ R Y+G+L G+ + LED ++
Sbjct: 510 TQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSI 569
Query: 543 RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHP 601
+NAF + G+ + L+ + Q W++ ++ + + T S+
Sbjct: 570 KNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET--GFSITELQRKQAM 627
Query: 602 VTPSSKHADSKPAPL-TPAYHTLPHPSHHGTPHTTINWGPL---EPPKTPKPWSLSCLRP 657
+ S + KP + P Y L H P L EP + P + S R
Sbjct: 628 LNASKQQVTGKPKAVGRPCY--LTRQKHPALPSNRPQQQVLVLAEPRRKPSTFWHSISRL 685
Query: 658 AP 659
AP
Sbjct: 686 AP 687
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 135 bits (341), Expect = 1e-31
Identities = 111/465 (23%), Positives = 207/465 (44%), Gaps = 21/465 (4%)
Query: 141 SVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNE 200
+VCA +D L S S H + G+ +++ + + + A ++ ++
Sbjct: 152 AVCADEVGSEEDLYDDLHSSS-HHYSHPGGGGEQLAINELISDGSVVCAEALWDHVTMDD 210
Query: 201 DELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTLKS 257
EL F GDVI V WW G + GWFP+++VR ++P +P +G +
Sbjct: 211 QELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGA 270
Query: 258 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISYLM 316
G + + V+ IL TE +Y K L+ + Y+R + ++ S + +
Sbjct: 271 EDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIF 330
Query: 317 GNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA---V 372
GN+E+I Q+ V++LE+ +G CFL + +Y YC NHP+A +
Sbjct: 331 GNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACVEL 389
Query: 373 NVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQ 432
+ LT+ S+ + F + + L L P ++ KYP L EL ++ H D +
Sbjct: 390 SRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFK 449
Query: 433 DIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQC 490
D++ ++ A KN++ E ++R E ++ +I +WEG+D+ + S L +
Sbjct: 450 DVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRV 509
Query: 491 AGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH------ 542
+ K+ +R LF + L+ R Y+G+L G+ + LED ++
Sbjct: 510 TQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSI 569
Query: 543 RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPT 586
+NAF + G+ + L+ + Q W++ ++ + + T
Sbjct: 570 KNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 124 bits (310), Expect = 5e-28
Identities = 104/423 (24%), Positives = 183/423 (43%), Gaps = 26/423 (6%)
Query: 172 GQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTG 231
G+ +++ + N + A ++ ++ EL F GDVI V WW G +
Sbjct: 135 GEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEA 194
Query: 232 WFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTT------AINKSYYNV-VLQNILETEN 284
WFP+++VR ++ +++ +S S + S + + + NK V++ I++TE
Sbjct: 195 WFPASFVR-LRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTER 253
Query: 285 EYSKELQTVLSTYLRPLQT-SEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ 343
Y K L+ + Y+R + + + A ++ + GN+E+I FQ+ ++ LE+ E
Sbjct: 254 VYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPH 313
Query: 344 -QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE--LGEFMETKGASSPGILVLT 400
+G CFL +Y YC NHP A L ++ F E I +
Sbjct: 314 LSEIGSCFLQNQEGF-AIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAI 372
Query: 401 TG-LSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELEL 459
G L P ++ KYP L EL ++ H D +I+ + A KN++ E RKRK +
Sbjct: 373 DGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINE-RKRKLESI 431
Query: 460 QILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-P 515
+ +I WEG DI + S L + + +R LF + L+
Sbjct: 432 DKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLL 491
Query: 516 RMSGFIYQGKLPTTGMTITKLEDSENH------RNAFEISGSMIERILVSC-NNQQDLQE 568
R Y+G+L M + L D + +NAF++ + + + C Q+D
Sbjct: 492 RRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKAR 551
Query: 569 WVE 571
W++
Sbjct: 552 WLQ 554
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 117 bits (292), Expect = 6e-26
Identities = 88/312 (28%), Positives = 152/312 (48%), Gaps = 18/312 (5%)
Query: 271 YYNVVLQNILETENEYSKELQTVLSTYLRPL--QTSEKLSSANISYLMGNLEEICSFQQM 328
Y + V+Q ILETE Y ++L++++ YL + QT L + S L GN+++I F
Sbjct: 113 YVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSE 172
Query: 329 LVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFM 386
L+Q LE C P A + CF++ + +Y YC N+P +V VLTE ++ L +F
Sbjct: 173 LLQDLENCENDPVA---IAECFVSKSEEFH-IYTQYCTNYPRSVAVLTECMRNKILAKFF 228
Query: 387 ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSA 446
+ + L L + L KP R+ KY LL E+E H++ + ++ + ++
Sbjct: 229 RERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAW 288
Query: 447 QCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLF 504
+++++ E + LQ + + NW+G D+ + G + IQ A KNER L LF
Sbjct: 289 HINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRA----KNERTLFLF 344
Query: 505 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSEN-HRNAFEISGSMIERILVSCNNQ 563
+LL+ R F Y+ + + + ++ E + F ++ V +Q
Sbjct: 345 DKLLLI--TKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQH-TVQAKSQ 401
Query: 564 QDLQEWVEHLQK 575
QD + WV HL++
Sbjct: 402 QDKRLWVLHLKR 413
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 109 bits (273), Expect = 9e-24
Identities = 96/405 (23%), Positives = 170/405 (41%), Gaps = 31/405 (7%)
Query: 202 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR-----EVKASEKPVSPKSGTLK 256
EL+F GDVI V WW G ++ GWFP+++VR E + E P ++G L
Sbjct: 26 ELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHL- 84
Query: 257 SPPKGFDTTAINKSYYN------VVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSS 309
D + + N V+ I+ TE Y K L+ + YL+ + + S
Sbjct: 85 --DPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSD 142
Query: 310 ANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANH 368
+ + GN+E+I FQ V+ LE+ + +G CFL +Y YC NH
Sbjct: 143 EQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYCNNH 201
Query: 369 PSAVNVLTE--HSEELGEFMETKGASSPGILVLTTG-LSKPFMRLDKYPTLLKELERHME 425
A L++ F E I + G L P ++ KYP L EL ++
Sbjct: 202 LDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTA 261
Query: 426 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDI-KTLGNVTY 482
H+D + + ++A +N++ Q E ++R E ++ ++ +WEG+DI + Y
Sbjct: 262 QDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIY 321
Query: 483 MSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSEN 541
++ +R LF + +++ R Y+G++ + +ED +
Sbjct: 322 TGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRD 381
Query: 542 H------RNAFEISGSMIERI-LVSCNNQQDLQEWVEHLQKQTKV 579
+NAF++ E I L ++ W+ +++ K+
Sbjct: 382 DDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKM 426
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 106 bits (264), Expect = 1e-22
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 189 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 248
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1163
Query: 249 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 308
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 1164 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1219
Query: 309 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 365
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 1220 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1278
Query: 366 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 421
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 1279 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1338
Query: 422 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 456
+ + H D ++ ++ + L +Q E + KE
Sbjct: 1339 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1373
Score = 64.7 bits (156), Expect = 3e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 190 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 245
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
Query: 246 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 279
K VSPK L S P + A Y NV N+
Sbjct: 796 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840
Score = 48.1 bits (113), Expect = 3e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 191 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 250
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 961 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1019
Query: 251 KSGTLKSPPK 260
KSG P+
Sbjct: 1020 KSGASNKKPE 1029
Score = 47.4 bits (111), Expect = 5e-05
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 187 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 245
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +YV+ + SE
Sbjct: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 931
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 106 bits (264), Expect = 1e-22
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 189 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 248
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1190
Query: 249 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 308
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 1191 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1246
Query: 309 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 365
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 1247 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1305
Query: 366 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 421
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 1306 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1365
Query: 422 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 456
+ + H D ++ ++ + L +Q E + KE
Sbjct: 1366 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1400
Score = 64.7 bits (156), Expect = 3e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 190 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 245
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 246 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 279
K VSPK L S P + A Y NV N+
Sbjct: 823 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 867
Score = 48.1 bits (113), Expect = 3e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 191 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 250
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 988 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1046
Query: 251 KSGTLKSPPK 260
KSG P+
Sbjct: 1047 KSGASNKKPE 1056
Score = 47.4 bits (111), Expect = 5e-05
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 187 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 245
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +YV+ + SE
Sbjct: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 958
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 103 bits (256), Expect = 8e-22
Identities = 66/271 (24%), Positives = 131/271 (48%), Gaps = 13/271 (4%)
Query: 193 FNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKS 252
+++ N+DEL+F+KG +I+V E+ WW+G +NG+ G FPSNYV+ + P
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK-LTTDMDPSQQWC 1222
Query: 253 GTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI 312
L T + Y + ++ TE Y +LQ V + +PL SE L+ +
Sbjct: 1223 SDLHLLDMLTPTERKRQGY----IHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEV 1278
Query: 313 SYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYCANHP 369
+ + N +E+ L+++L K+ + + +G +P M+ Y+ +C+
Sbjct: 1279 AMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQP-YIRFCSRQL 1337
Query: 370 SAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELERHME 425
+ ++ + ++E +F E + A P + L++ + KP R+ +YP ++K + +
Sbjct: 1338 NGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTP 1397
Query: 426 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 456
+ H D ++ ++ + L +Q E + KE
Sbjct: 1398 ENHPDHSHLKHALEKAEELCSQVNEGVREKE 1428
Score = 58.2 bits (139), Expect = 3e-08
Identities = 26/70 (37%), Positives = 44/70 (62%), Gaps = 1/70 (1%)
Query: 191 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 250
A + ++ + + +L+F +GDVI VT+ ++G WW GT+ + G FPSNYVR + +
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTK-KDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 251 KSGTLKSPPK 260
K+G+L P+
Sbjct: 1068 KTGSLGKKPE 1077
Score = 55.1 bits (131), Expect = 3e-07
Identities = 26/78 (33%), Positives = 43/78 (55%), Gaps = 9/78 (11%)
Query: 190 RAKFNFQQTNEDELSFSKGDVIHV-------TRVEEGGWWEGTLNGRTGWFPSNYVREVK 242
RA + F+ + DE++ GD++ V ++ E GW G L G+TGWFP+NY ++
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 243 ASE--KPVSPKSGTLKSP 258
+E PV P + + +P
Sbjct: 806 ENEVPAPVKPVTDSTSAP 823
Score = 51.2 bits (121), Expect = 4e-06
Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 12/92 (13%)
Query: 194 NFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGR-----TGWFPSNYVREVKASEKPV 248
++ T ++L+ + G +I + + GGWWEG L R GWFP+NYV+ + +
Sbjct: 1084 SYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKI 1143
Query: 249 SPKSGTLKSPPKGFDTTAINK--SYYNVVLQN 278
+P PPK A+ + Y+ QN
Sbjct: 1144 TP-----TEPPKSTALAAVCQVIGMYDYTAQN 1170
Score = 49.7 bits (117), Expect = 1e-05
Identities = 25/73 (34%), Positives = 42/73 (57%), Gaps = 2/73 (2%)
Query: 187 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKAS-E 245
L +A + ++ ++ L+F+K DVI V ++ WW G + G+ GWFP +YV+ +
Sbjct: 916 LQAQALYPWRAKKDNHLNFNKNDVITVLE-QQDMWWFGEVQGQKGWFPKSYVKLISGPIR 974
Query: 246 KPVSPKSGTLKSP 258
K S SG+ +SP
Sbjct: 975 KSTSMDSGSSESP 987
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 98.6 bits (244), Expect = 2e-20
Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 33/306 (10%)
Query: 275 VLQNILETENEYSKELQTVLSTYLRPLQTS------EKLSSANISYLMGNLEEICSFQQM 328
VL IL TE +Y L+ + S +L ++ + + L+ N+ L N+E+I +
Sbjct: 53 VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112
Query: 329 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 385
+ +LE C P++Q +G FL + +Y YC+NH A+ +L E ++ + F
Sbjct: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKF-CVYEEYCSNHEKALRLLVELNKIPTVRAF 171
Query: 386 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 442
+ + G + L L P R+ KYP LLKEL + H D +Q ++ A K
Sbjct: 172 LLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMK 231
Query: 443 NLSAQCQEVRKRKE-LE-LQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERY 500
+ + E +++ E LE L+ L I WEG ++ + + L++ + + ER
Sbjct: 232 TVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQ-ERA 290
Query: 501 LLLFPNVLLMLSASPRMSG---------------FIYQGKLPTTGMTITKLED--SENHR 543
LF N+L+ R++G +I++G++ T M + +ED ++ H
Sbjct: 291 FFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHS 350
Query: 544 NAFEIS 549
N + ++
Sbjct: 351 NGYTVT 356
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 95.5 bits (236), Expect = 2e-19
Identities = 84/336 (25%), Positives = 154/336 (45%), Gaps = 37/336 (11%)
Query: 275 VLQNILETENEYSKELQTVLSTYLRPL------QTSEKLSSANISYLMGNLEEICSFQQM 328
VL + +TE +Y L+ ++S +L + + + ++ + L N+E+I + +
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 329 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 385
++ +EEC P AQQ VG CFL+ + + +Y YC+NH A +L E ++ + F
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLELNKIRTIRTF 145
Query: 386 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 442
+ G + L L P R+ KYP +LKEL + H+D + +++ A K
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205
Query: 443 NLSAQCQEVRKRKELELQILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNER 499
+ + E +++ E +L++L E I WEG +I M VL++ + S ER
Sbjct: 206 AVCSNINEAKRQME-KLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS-SGNIQER 263
Query: 500 YLLLFPNVLLML----------SASPRMSGFIYQGKLPTTGMTITKLED------SENH- 542
LF N+L+ AS ++++G++ T M + ++D S H
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHI 323
Query: 543 -RNAFEISGSMIERILV-SCNNQQDLQEWVEHLQKQ 576
N ++I + + V ++ EW E + K+
Sbjct: 324 VVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 95.5 bits (236), Expect = 2e-19
Identities = 84/336 (25%), Positives = 154/336 (45%), Gaps = 37/336 (11%)
Query: 275 VLQNILETENEYSKELQTVLSTYLRPL------QTSEKLSSANISYLMGNLEEICSFQQM 328
VL + +TE +Y L+ ++S +L + + + ++ + L N+E+I + +
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 329 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 385
++ +EEC P AQQ VG CFL+ + + +Y YC+NH A +L E ++ + F
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLELNKIRTIRTF 145
Query: 386 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 442
+ G + L L P R+ KYP +LKEL + H+D + +++ A K
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205
Query: 443 NLSAQCQEVRKRKELELQILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNER 499
+ + E +++ E +L++L E I WEG +I M VL++ + S ER
Sbjct: 206 AVCSNINEAKRQME-KLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS-SGNIQER 263
Query: 500 YLLLFPNVLLML----------SASPRMSGFIYQGKLPTTGMTITKLED------SENH- 542
LF N+L+ AS ++++G++ T M + ++D S H
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHI 323
Query: 543 -RNAFEISGSMIERILV-SCNNQQDLQEWVEHLQKQ 576
N ++I + + V ++ EW E + K+
Sbjct: 324 VVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 86.7 bits (213), Expect = 8e-17
Identities = 87/373 (23%), Positives = 150/373 (40%), Gaps = 20/373 (5%)
Query: 268 NKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQ 327
+K+Y+ + + + TE Y K+L+ + S + + + + A S + N E + F
Sbjct: 539 DKAYF--IAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHT 596
Query: 328 MLVQSLEECTKLPEAQ--------QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVL---T 376
++ +E+ L E + QR+G L + MK L + H A+ L
Sbjct: 597 NFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHL-AAHLWKHSEALEALENGI 655
Query: 377 EHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQK 436
+ S L F L L T L +P RL Y +L+ L +H H D +D +
Sbjct: 656 KSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRA 715
Query: 437 SMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEK 496
++A + AQ + E Q L E ++ G D + ++ + +
Sbjct: 716 ALAEITEMVAQLHGTMIKME-NFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGL 774
Query: 497 NERYLLLFPNVLLMLSASPRMSG-FIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIER 555
+R LF +VLL S S F G+LP GMTI + ED + + G +
Sbjct: 775 QQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQR-QS 833
Query: 556 ILVSCNNQQDLQEWVEHLQKQ---TKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 612
I+V+ +++ ++++WVE +Q + +S P S P + P + D
Sbjct: 834 IIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDL 893
Query: 613 PAPLTPAYHTLPH 625
A T PH
Sbjct: 894 SASRTSLERQAPH 906
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 85.5 bits (210), Expect = 2e-16
Identities = 76/313 (24%), Positives = 145/313 (46%), Gaps = 22/313 (7%)
Query: 275 VLQNILETENEYSKELQTVLSTYLRPLQTSEKL--SSANISYLMGNLEEICSFQQMLVQS 332
V + I+ETE Y ++L++++ YL PL L S + L N+E+I F L++
Sbjct: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLED 165
Query: 333 LEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFMETKG 390
LE + + + CF+ +Y YC N+PS++ +L E S +++ +
Sbjct: 166 LENSS----SAGGIAECFVQRSEDFD-IYTLYCMNYPSSLALLRELSLSPPAALWLQERQ 220
Query: 391 ASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMED--YHTDRQDIQKSMAAFKNLSAQC 448
A L L + L KP R+ KY LL+EL +H + R+ +++++ + ++
Sbjct: 221 AQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYI 280
Query: 449 QEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSE--EKNERYLLLF 504
++++++E LQ + + W G ++ G + G ER L LF
Sbjct: 281 NDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLF 340
Query: 505 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMI--ERILVSCNN 562
+LL+ A R + Y+G + ++++ +S F++S I R L+ N
Sbjct: 341 SRMLLV--AKRRGLEYTYKGHIFCCNLSVS---ESPRDPLGFKVSDLTIPKHRHLLQAKN 395
Query: 563 QQDLQEWVEHLQK 575
Q++ + W+ LQ+
Sbjct: 396 QEEKRLWIHCLQR 408
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 79.3 bits (194), Expect = 1e-14
Identities = 80/348 (22%), Positives = 152/348 (43%), Gaps = 16/348 (4%)
Query: 240 EVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLST-YL 298
E K E+ L+ + + N+ + + +L TE Y L + Y
Sbjct: 175 ETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYC 234
Query: 299 RPLQTSEKLS--SANISYLMGNLEEICSFQ-QMLVQSLEECTKLPEAQQRVGGCFLNLMP 355
+ L+ + + S + ++ + N+ I +F + L+ LE+ + E R+G L P
Sbjct: 235 KLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAP 294
Query: 356 QMKTLYLTYCANHPSAVNVLTEHSEELGEFM----ETKGASSPGILVLTTGLSKPFMRLD 411
+K +Y Y +A+ ++ +E + +F E + G L L + +P R+
Sbjct: 295 FLK-MYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIP 353
Query: 412 KYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQE-VRKRKELELQILTEAIRNWE 470
+Y LLK+ R + D D +KS+ ++ +RK + L+ + + E
Sbjct: 354 RYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEE 413
Query: 471 GDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSG--FIYQGKLPT 528
D + + Q+L A + ERYL LF N+LL + G F + ++
Sbjct: 414 EDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGI 473
Query: 529 TGMTITKLEDSENHRNAFEISGSMIERIL-VSCNNQQDLQEWVEHLQK 575
GM I + + +E + + F++SG ER L + ++ QD +EW++ LQ+
Sbjct: 474 DGMKIVETQ-NEEYPHTFQVSGK--ERTLELQASSAQDKEEWIKALQE 518
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 79.0 bits (193), Expect = 2e-14
Identities = 77/340 (22%), Positives = 145/340 (42%), Gaps = 18/340 (5%)
Query: 275 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 334
+++ IL TE Y K+L+ + + + + + + ++ L N++ I F + ++ +E
Sbjct: 539 IVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVE 598
Query: 335 ECTKLPE---------AQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVL---TEHSEEL 382
+ L E + QR+G L M Q+K + +Y H + L T+ ++L
Sbjct: 599 QRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKE-FTSYFQRHDEVLTELEKATKRCKKL 657
Query: 383 GEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 442
+ L L T L KP RL Y LL+ L H H D D ++ A
Sbjct: 658 EAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAIT 717
Query: 443 NLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLL 502
++ Q + R E LQ LTE R+ G + ++ + + + +R
Sbjct: 718 EVTTTLQHILIRLE-NLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFF 776
Query: 503 LFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN 561
LF ++LL S S F +G LP GM + + ++ + + F I + + I+V+ +
Sbjct: 777 LFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQ-KTIVVAAS 835
Query: 562 NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHP 601
+ + ++W+ L + G T ++P T+ + P
Sbjct: 836 TRLEKEKWMLDLNSAIQAAKSGGDTAP--ALPGRTVCTRP 873
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 78.6 bits (192), Expect = 2e-14
Identities = 75/322 (23%), Positives = 154/322 (47%), Gaps = 50/322 (15%)
Query: 275 VLQNILETENEYSKELQTVLSTYLRPLQTS-EKLSSANIS---YLMGNLEEICSFQQ-ML 329
++ +++TE Y ++L+ + TYL + + E++ ++ + GN++EI F +
Sbjct: 1296 IMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIF 1355
Query: 330 VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHS-EELGEFMET 388
++ LE+ +LPE VG CF+ + + +Y+TYC N P + ++ EH+ E +
Sbjct: 1356 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSTQLILEHAGSYFDEIQQR 1411
Query: 389 KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAA-------- 440
G ++ +++ L KP R+ KY LLKEL E+ + +D + M +
Sbjct: 1412 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDA 1467
Query: 441 --FKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNE 498
L + + + EL IL E+ + W D KTL + E
Sbjct: 1468 MHLSMLEGFDENIESQGEL---ILQESFQVW---DPKTL---------------IRKGRE 1506
Query: 499 RYLLLFPNVLLM---LSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEI--SGSMI 553
R+L LF L+ + S S ++Y+ KL T+ + +T+ + + + A + + +
Sbjct: 1507 RHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSD 1566
Query: 554 ERILVSCNNQQDLQEWVEHLQK 575
+I++ ++ ++ Q+W++H+++
Sbjct: 1567 NKIVLKASSIENKQDWIKHIRE 1588
Score = 70.9 bits (172), Expect = 5e-12
Identities = 75/361 (20%), Positives = 161/361 (44%), Gaps = 38/361 (10%)
Query: 234 PSNYVREVKASEKP-VSPKSGTLKSPPKGFD------TTAINKSYYNVVLQNILETENEY 286
PS+ + + S P +P +L S D ++++ + +Y VLQ ++ETE +Y
Sbjct: 1927 PSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHY--VLQELVETERDY 1984
Query: 287 SKELQTVLSTYLRPLQTSEKLSS--ANISYLMGNLEEICSFQQ-MLVQSLEECTKLPEAQ 343
++L V+ Y+ ++ + GN+ +I + + + LE+C + PE
Sbjct: 1985 VRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPE-- 2042
Query: 344 QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGL 403
++G F+ ++ +Y+ YC N P + ++++E+ + E ++ + L LT L
Sbjct: 2043 -KLGSLFVKHERRLH-MYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHR---LQLTDLL 2097
Query: 404 SKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILT 463
KP R+ KY LLK+ ++ + D ++++++ + +C ++ L+
Sbjct: 2098 IKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQ----- 2152
Query: 464 EAIRNWEGDDIKTLGNVTYMSQVLI--QCAGSEEK-NERYLLLFPNVLLMLSASPRMSGF 520
++G I G + L+ Q AG + ER + LF +++ + GF
Sbjct: 2153 ----GFDG-KIVAQGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGF 2207
Query: 521 IYQGKLPTTGMTITKL---EDSENHRNAFEI---SGSMIERILVSCNNQQDLQEWVEHLQ 574
G L + ++ L E+ EN F + +G ++E ++ ++ Q W+ +
Sbjct: 2208 SMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEIN 2267
Query: 575 K 575
+
Sbjct: 2268 Q 2268
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 78.2 bits (191), Expect = 3e-14
Identities = 82/358 (22%), Positives = 160/358 (44%), Gaps = 54/358 (15%)
Query: 275 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI----SYLMGNLEEICSFQQ-ML 329
++ +L+TE Y ++L L TYL + + + I + GN++EI F +
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344
Query: 330 VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE-LGEFMET 388
++ LE+ +LPE VG CF+ + + +Y+TYC N P + ++ EH+ E +
Sbjct: 1345 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSNQLILEHAGTFFDEIQQR 1400
Query: 389 KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC 448
G ++ +++ L KP R+ KY LLKEL E+ + +D + M + +
Sbjct: 1401 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDA 1456
Query: 449 QEVRK----RKELELQ---ILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 501
V + L++Q IL +A + W+ + G ER+L
Sbjct: 1457 MHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------------RERHL 1498
Query: 502 LLFPNVLLMLSASPRMSG---FIYQGKLPTTGMTITKLEDSENHRNAF--EISGSMIERI 556
LF L+ SG ++Y+ KL T+ + +T+ + + + A + S +
Sbjct: 1499 FLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKT 1558
Query: 557 LVSCNNQQDLQEWVEHLQK--QTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 612
++ +N + QEW++++++ Q ++ + +P +P TP+ + +SK
Sbjct: 1559 VLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPK--------TPAKQRNNSK 1608
Score = 69.3 bits (168), Expect = 1e-11
Identities = 109/512 (21%), Positives = 210/512 (41%), Gaps = 61/512 (11%)
Query: 275 VLQNILETENEYSKELQTVLSTYLRPLQTS---EKLSSANISYLMGNLEEICSFQQ-MLV 330
VL +++TE +Y K+L V+ +++ ++ E + + + GN+ +I + + +
Sbjct: 1933 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKD-KIVFGNIHQIYDWHKDFFL 1991
Query: 331 QSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKG 390
LE+C + Q R+ F+ ++ +Y+ YC N P + ++ E+ E +
Sbjct: 1992 AELEKCI---QEQDRLAQLFIKHERKLH-IYVWYCQNKPRSEYIVAEYDAYFEEVKQEIN 2047
Query: 391 ASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQE 450
L L+ L KP R+ KY LLK+ R+ E + DI+K++ + +C +
Sbjct: 2048 QR----LTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCND 2103
Query: 451 VRKRKELELQILTEAIRNWEGD---DIKTLGNVTYMSQVLIQCAGSEEK-NERYLLLFPN 506
+ L+ +EG K L T+ V+ AG + + ER + LF
Sbjct: 2104 MMNLGRLQ---------GFEGTLTAQGKLLQQDTF--YVIELDAGMQSRTKERRVFLFEQ 2152
Query: 507 VLL---MLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQ 563
+++ +L G++++ + + + + D++ + A ++ ER+++ N
Sbjct: 2153 IVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL-MNRETSERVVLQAANA 2211
Query: 564 QDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTL 623
Q WV+ + N ++ + L S P+ K + PA L
Sbjct: 2212 DIQQAWVQDI----------NQVLETQRDFLNALQS-PIEYQRKERSTAVMRSQPA--RL 2258
Query: 624 PHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKL 683
P S P++++ G +PPK S P PPL+ S + + SP
Sbjct: 2259 PQASPR--PYSSVPAGSEKPPK-----GSSYNPPLPPLKISTS-------NGSPGFEYHQ 2304
Query: 684 LPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNH 743
+ K +D + S+ A+ +D LK E + + Q L Q L++
Sbjct: 2305 PGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQP 2364
Query: 744 VLADDDQPSLDSLGRRSSLSRLEPSDLSEDSD 775
A D P+ + S L+ L + +E SD
Sbjct: 2365 --ASDHSPAAEGWVPGSILAPLTKATAAESSD 2394
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 78.2 bits (191), Expect = 3e-14
Identities = 82/358 (22%), Positives = 160/358 (44%), Gaps = 54/358 (15%)
Query: 275 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI----SYLMGNLEEICSFQQ-ML 329
++ +L+TE Y ++L L TYL + + + I + GN++EI F +
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344
Query: 330 VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE-LGEFMET 388
++ LE+ +LPE VG CF+ + + +Y+TYC N P + ++ EH+ E +
Sbjct: 1345 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSNQLILEHAGTFFDEIQQR 1400
Query: 389 KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC 448
G ++ +++ L KP R+ KY LLKEL E+ + +D + M + +
Sbjct: 1401 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDA 1456
Query: 449 QEVRK----RKELELQ---ILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 501
V + L++Q IL +A + W+ + G ER+L
Sbjct: 1457 MHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------------RERHL 1498
Query: 502 LLFPNVLLMLSASPRMSG---FIYQGKLPTTGMTITKLEDSENHRNAF--EISGSMIERI 556
LF L+ SG ++Y+ KL T+ + +T+ + + + A + S +
Sbjct: 1499 FLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKT 1558
Query: 557 LVSCNNQQDLQEWVEHLQK--QTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 612
++ +N + QEW++++++ Q ++ + +P +P TP+ + +SK
Sbjct: 1559 VLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPK--------TPAKQRNNSK 1608
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 78.2 bits (191), Expect = 3e-14
Identities = 60/213 (28%), Positives = 95/213 (44%), Gaps = 23/213 (10%)
Query: 238 VREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTY 297
+ E+ S++ SP+ T P + V+ +LETE Y K+L ++ Y
Sbjct: 1009 LHEMNPSDQSPSPQDST--GPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERY 1066
Query: 298 LRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKL-PEAQQ------------ 344
L+PLQ L+ + L GNL E+ FQ +++LE+ +L P+ ++
Sbjct: 1067 LKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLF 1126
Query: 345 RVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELG--EFMETKGASSPGILVLTTG 402
+GG FL + K LY +CA+H VL + + F++ + L +
Sbjct: 1127 SLGGSFLYYADRFK-LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESY 1185
Query: 403 LSKPFMRLDKYPTLLKEL-----ERHMEDYHTD 430
L KP R+ KYP LL+EL E YH D
Sbjct: 1186 LIKPIQRILKYPLLLRELFALTDAESEEHYHLD 1218
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
Length = 626
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)
Query: 258 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 317
PP+ + V+Q +++TE Y K+L + YL PLQ L+ + L G
Sbjct: 11 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 70
Query: 318 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 364
+L E+ FQ++ +++LE+ + P ++ +GG FL K LY +
Sbjct: 71 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 129
Query: 365 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 422
CANH VL + + F++ + + L + L KP R+ KYP LLKEL
Sbjct: 130 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 189
Query: 423 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 453
+ + + +++ A + +++ E++K
Sbjct: 190 LTDQESEEHYHLTEALKAMEKVASHINEMQK 220
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)
Query: 258 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 317
PP+ + V+Q +++TE Y K+L + YL PLQ L+ + L G
Sbjct: 1086 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 1145
Query: 318 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 364
+L E+ FQ++ +++LE+ + P ++ +GG FL K LY +
Sbjct: 1146 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 1204
Query: 365 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 422
CANH VL + + F++ + + L + L KP R+ KYP LLKEL
Sbjct: 1205 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 1264
Query: 423 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 453
+ + + +++ A + +++ E++K
Sbjct: 1265 LTDQESEEHYHLTEALKAMEKVASHINEMQK 1295
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 74.3 bits (181), Expect = 4e-13
Identities = 48/197 (24%), Positives = 96/197 (48%), Gaps = 19/197 (9%)
Query: 275 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 334
V++ +L+TE +Y ++L+ + + P+Q ++ + + + L GN++ + + L+ +LE
Sbjct: 788 VIEELLQTERDYIRDLEMCIERIMVPMQQAQ-VPNIDFEGLFGNMQMVIKVSKQLLAALE 846
Query: 335 ECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLT--EHSEELGEFMETKGAS 392
VG FL +++ Y YC NH A+ +L E E++ + ++ A
Sbjct: 847 -------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLAD 899
Query: 393 SPGI---------LVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKN 443
+ + L + L KP R+ +YP LL EL + H D+ + ++ A K
Sbjct: 900 LKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKE 959
Query: 444 LSAQCQEVRKRKELELQ 460
++ E ++RK+L L+
Sbjct: 960 INVNINEYKRRKDLVLK 976
Score = 52.8 bits (125), Expect = 1e-06
Identities = 27/73 (36%), Positives = 38/73 (52%), Gaps = 3/73 (4%)
Query: 191 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR---EVKASEKP 247
A + FQ +EL F GD I + E GW EG+L GRTG FP +V+ + + E
Sbjct: 250 ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETM 309
Query: 248 VSPKSGTLKSPPK 260
P+ G+L P+
Sbjct: 310 ALPQEGSLARIPE 322
Score = 47.0 bits (110), Expect = 7e-05
Identities = 22/49 (44%), Positives = 28/49 (57%)
Query: 190 RAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 238
RA ++EL F +GDVI + V E GW+EG L GR G FP +V
Sbjct: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFV 199
Score = 40.8 bits (94), Expect = 0.005
Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 5/82 (6%)
Query: 165 RTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEE----GG 220
RT++ + + D ++ NQ V A + F+ N +ELS S + + ++
Sbjct: 1495 RTAQAPEDRSTEPDGSEAEGNQ-VYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTE 1553
Query: 221 WWEGTLNGRTGWFPSNYVREVK 242
WW +NG+ G+ PSNY+R+ +
Sbjct: 1554 WWLAEVNGKKGYVPSNYIRKTE 1575
Score = 38.1 bits (87), Expect = 0.033
Identities = 22/54 (40%), Positives = 29/54 (53%)
Query: 188 VVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 241
VVRA F+F + +EL GD+I V V + W G TG FPS++V V
Sbjct: 6 VVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIV 59
Score = 32.7 bits (73), Expect = 1.4
Identities = 17/53 (32%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 195 FQQTNEDELSFSKGDVIHVTRVEEGGWWEG-TLNGRTGWFPSNYVREVKASEK 246
F D L +GD++ + + GW +G + G G+FPS+ VRE+ S +
Sbjct: 77 FTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQ 129
>gi|55749621 pleckstrin homology domain containing, family G, member
3 [Homo sapiens]
Length = 1163
Score = 73.2 bits (178), Expect = 9e-13
Identities = 59/270 (21%), Positives = 116/270 (42%), Gaps = 31/270 (11%)
Query: 312 ISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSA 371
+SYL + EI ++M VQ L + E +Y YC N+P++
Sbjct: 91 LSYLGRVVREIVETERMYVQDLRSIVESQEFD----------------IYTQYCNNYPNS 134
Query: 372 VNVLTE--HSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHT 429
V LTE ++ +F + L L + L KP R+ KY LL+E+ +H ++
Sbjct: 135 VAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEED 194
Query: 430 DRQDIQKSMAAFKNLSAQCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVL 487
+ ++ ++ ++ ++++R E + LQ + + NW+G D+ T G +
Sbjct: 195 GFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEGTFR 254
Query: 488 IQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFE 547
+ +NER LF LL+ R F+Y+G +P + + L +S F
Sbjct: 255 VH----RVRNERTFFLFDKTLLI--TKKRGDHFVYKGNIPCSSL---MLIESTRDSLCFT 305
Query: 548 IS--GSMIERILVSCNNQQDLQEWVEHLQK 575
++ ++ + ++ + W H+++
Sbjct: 306 VTHYKHSKQQYSIQAKTVEEKRNWTHHIKR 335
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 71.6 bits (174), Expect = 3e-12
Identities = 45/132 (34%), Positives = 68/132 (51%), Gaps = 7/132 (5%)
Query: 192 KFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPK 251
+F++Q ++DEL+ S G++I R E+GGWWEG +NGR G FP N+VRE+K K +
Sbjct: 7 EFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIK---KEMKKD 63
Query: 252 SGTLKSPPKGFDTTAINKSYYNVVLQNILET--ENEYSKELQTVLSTYLRPLQTSEKLSS 309
T K+P K S + + IL T E + V +YL +L
Sbjct: 64 PLTNKAPEKPLHEVPSGNSLLS--SETILRTNKRGERRRRRCQVAFSYLPQNDDELELKV 121
Query: 310 ANISYLMGNLEE 321
+I ++G +EE
Sbjct: 122 GDIIEVVGEVEE 133
Score = 65.1 bits (157), Expect = 2e-10
Identities = 34/93 (36%), Positives = 49/93 (52%), Gaps = 12/93 (12%)
Query: 149 HRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKG 208
H + S +SL S RT+K + + R + F++ N+DEL G
Sbjct: 75 HEVPSGNSLLSSETILRTNKRGERRRRRCQVA------------FSYLPQNDDELELKVG 122
Query: 209 DVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 241
D+I V E GWWEG LNG+TG FPSN+++E+
Sbjct: 123 DIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 155
Score = 54.3 bits (129), Expect = 4e-07
Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 10/89 (11%)
Query: 178 DMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVE--EGGWWEGTLNGRTGWFPS 235
+M + ++ + F ++ N+DEL+ +GD++ + + + GWWEG LNGR G FP
Sbjct: 261 EMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPD 320
Query: 236 NYV--------REVKASEKPVSPKSGTLK 256
N+V +E +KP P + +K
Sbjct: 321 NFVKLLPPDFEKEGNRPKKPPPPSAPVIK 349
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,908,766
Number of Sequences: 37866
Number of extensions: 1674450
Number of successful extensions: 6981
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 225
Number of HSP's successfully gapped in prelim test: 368
Number of HSP's that attempted gapping in prelim test: 5807
Number of HSP's gapped (non-prelim): 1253
length of query: 803
length of database: 18,247,518
effective HSP length: 110
effective length of query: 693
effective length of database: 14,082,258
effective search space: 9759004794
effective search space used: 9759004794
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.