Search of human proteins with 164519084

Search of human proteins with 164519084

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
         (1069 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]          2121   0.0  
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo...  1048   0.0  
gi|68299759 ecotropic viral integration site 5 [Homo sapiens]         269   1e-71
gi|229577000 ecotropic viral integration site 5-like isoform 1 [...   266   8e-71
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H...   258   2e-68
gi|114688046 TBC1 domain family, member 4 [Homo sapiens]              232   1e-60
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member...   216   7e-56
gi|13994322 TBC1 domain family, member 10A [Homo sapiens]             140   5e-33
gi|167614488 TBC1 domain family, member 10B [Homo sapiens]            138   3e-32
gi|38348348 TBC1 domain family, member 10C [Homo sapiens]             135   2e-31
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]              125   3e-28
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]            125   3e-28
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso...   112   1e-24
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho...   112   2e-24
gi|148806902 TBC1 domain family, member 12 [Homo sapiens]             108   2e-23
gi|156231067 TBC1 domain family, member 8 [Homo sapiens]              108   4e-23
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]   107   8e-23
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]   107   8e-23
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]   107   8e-23
gi|29648315 small G protein signaling modulator 3 [Homo sapiens]      107   8e-23
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]   107   8e-23
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso...   105   2e-22
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso...   105   2e-22
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]   104   4e-22
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]     89   2e-17
gi|222352143 TBC1 domain family, member 2 [Homo sapiens]               82   2e-15
gi|34147456 TBC domain-containing protein kinase-like [Homo sapi...    79   2e-14
gi|38570103 TBC1 domain family, member 8B (with GRAM domain) iso...    78   4e-14
gi|109638751 ubiquitin specific protease 6 [Homo sapiens]              76   1e-13
gi|226693407 TBC1 domain family, member 3H [Homo sapiens]              75   3e-13

>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
          Length = 1069

 Score = 2121 bits (5495), Expect = 0.0
 Identities = 1069/1069 (100%), Positives = 1069/1069 (100%)

Query: 1    MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQL 60
            MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQL
Sbjct: 1    MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQL 60

Query: 61   QKELADVLMDPPMDDQPGEKELVKRSQLDGEGDGPLSNQLSASSTINPVPLVGLQKPEMS 120
            QKELADVLMDPPMDDQPGEKELVKRSQLDGEGDGPLSNQLSASSTINPVPLVGLQKPEMS
Sbjct: 61   QKELADVLMDPPMDDQPGEKELVKRSQLDGEGDGPLSNQLSASSTINPVPLVGLQKPEMS 120

Query: 121  LPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQI 180
            LPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQI
Sbjct: 121  LPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQI 180

Query: 181  SLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNA 240
            SLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNA
Sbjct: 181  SLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNA 240

Query: 241  ELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTPDSDIFTFSVSLEIKE 300
            ELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTPDSDIFTFSVSLEIKE
Sbjct: 241  ELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTPDSDIFTFSVSLEIKE 300

Query: 301  DDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSPGKDVRNS 360
            DDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSPGKDVRNS
Sbjct: 301  DDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSPGKDVRNS 360

Query: 361  DMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQE 420
            DMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQE
Sbjct: 361  DMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQE 420

Query: 421  PVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQRERKNNTDTLYEVVCLESE 480
            PVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQRERKNNTDTLYEVVCLESE
Sbjct: 421  PVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQRERKNNTDTLYEVVCLESE 480

Query: 481  SERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILET 540
            SERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILET
Sbjct: 481  SERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILET 540

Query: 541  WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKES 600
            WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKES
Sbjct: 541  WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKES 600

Query: 601  PQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLL 660
            PQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLL
Sbjct: 601  PQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLL 660

Query: 661  HMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEA 720
            HMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEA
Sbjct: 661  HMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEA 720

Query: 721  HMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGAL 780
            HMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGAL
Sbjct: 721  HMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGAL 780

Query: 781  KFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFER 840
            KFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFER
Sbjct: 781  KFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFER 840

Query: 841  ENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEE 900
            ENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEE
Sbjct: 841  ENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEE 900

Query: 901  EKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIE 960
            EKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIE
Sbjct: 901  EKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIE 960

Query: 961  KIRQKVDDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQ 1020
            KIRQKVDDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQ
Sbjct: 961  KIRQKVDDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQ 1020

Query: 1021 LVEAECKIQDLEHHLGLALNEVQAAKKTWFNRTLSSIKTATGVQGKETC 1069
            LVEAECKIQDLEHHLGLALNEVQAAKKTWFNRTLSSIKTATGVQGKETC
Sbjct: 1021 LVEAECKIQDLEHHLGLALNEVQAAKKTWFNRTLSSIKTATGVQGKETC 1069


>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
           sapiens]
          Length = 815

 Score = 1048 bits (2709), Expect = 0.0
 Identities = 533/842 (63%), Positives = 658/842 (78%), Gaps = 34/842 (4%)

Query: 1   MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQL 60
           M+ +AS+ K+S SSDSV+T+NSE+FVLV +  D+    N+   +EK  LKIV NG EQ L
Sbjct: 1   MEVRASLQKVSGSSDSVATMNSEEFVLVPQYADD----NSTKHEEKPQLKIVSNGDEQ-L 55

Query: 61  QKELADVLMDPPMDDQPGEKELVKRSQLDGEGDGPLSNQLSASSTINPVPLVGLQKPEMS 120
           +K + ++L D   + +P    +          D   S+++S  S    +P     KP + 
Sbjct: 56  EKAMEEILRDS--EKRPSSLLV----------DCQSSSEISDHS-FGDIPASQTNKPSLQ 102

Query: 121 LPVKPGQGDSEASSPFTP--VADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQC 178
           L + P   +     P +P  + +EDSV+F+KLTYLGC  V++PR+EVEALR M+ ++S  
Sbjct: 103 LILDPSNTEISTPRPSSPGGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKSSS 162

Query: 179 QISLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHY 238
           Q    VTL VPNV EG VR++D  +N EIA++PIYK+LFC RGHDGT ES+CFAFTES +
Sbjct: 163 QYPFPVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSH 222

Query: 239 NAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTPDSDIFTFSVSLEI 298
            +E F+IHVF CEI+EAVSRILYSF TAF+RS++Q      +   TPDSD+FTFSVSLE+
Sbjct: 223 GSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEV 282

Query: 299 KEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSPGKDVR 358
           KEDDGKG FS VPKD+D+  FKL+QGI+KK+VI VQQ +NKELAIERCFG+LLSPG++V+
Sbjct: 283 KEDDGKGNFSPVPKDRDKFYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVK 342

Query: 359 NSDMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEV 418
           NSDMHLLD+ESMGKS DG++YVITG WNP +P F  +NEETPKDK ++MT AVD+V+TEV
Sbjct: 343 NSDMHLLDMESMGKSYDGRAYVITGMWNPNAPVFLALNEETPKDKQVYMTVAVDMVVTEV 402

Query: 419 QEPVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQRERKNNTDTLYEVVCLE 478
            EPVRFLLET VRV   NER FW FS+++ TE FF++LKQ + +   N  D +YEVV L+
Sbjct: 403 VEPVRFLLETVVRVYPANER-FWYFSRKTFTETFFMRLKQSEGKGHTNAGDAIYEVVSLQ 461

Query: 479 SESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDE-EEDNDEPLLSGSGDVSKECAEKI 537
            ES++E   T        P SG      P  P+DDE EE++D  L SG+GDVSK+C EKI
Sbjct: 462 RESDKEEPVT--------PTSGGG----PMSPQDDEAEEESDNELSSGTGDVSKDCPEKI 509

Query: 538 LETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILIT 597
           L +WGELL KWH NL  RPK LS+LV++GVPEALR EVWQLLAGCH+N  ++++YRILIT
Sbjct: 510 LYSWGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILIT 569

Query: 598 KESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAV 657
           K+S Q+S ITRDI+RTFPAHDYFKDTGGDGQ+SLYKICKAYSVYDE+IGYCQGQSFLAAV
Sbjct: 570 KDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAV 629

Query: 658 LLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDIS 717
           LLLHMPEEQAF VLVKIM+DYGLR+L++ NFEDLHCKFYQLERLMQE +PDL++HF D++
Sbjct: 630 LLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLN 689

Query: 718 LEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFE 777
           LEAHMYASQWFLTLFTAKFPL MVFHIIDLLLCEG+++IF+VAL LLKTSK+DLL  DFE
Sbjct: 690 LEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFE 749

Query: 778 GALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIER 837
           GALKFFRVQLPKRYR+EENA++LME ACN+K+  KKLKKYEKEY TMRE Q QQEDP++R
Sbjct: 750 GALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDR 809

Query: 838 FE 839
           ++
Sbjct: 810 YK 811


>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
          Length = 810

 Score =  269 bits (687), Expect = 1e-71
 Identities = 175/532 (32%), Positives = 282/532 (53%), Gaps = 49/532 (9%)

Query: 524  SGSGDVSKECAEKILE--------TWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEV 575
            SGS  VS   A   L          WG ++++W      + KQ+  LV  G+P   R  V
Sbjct: 113  SGSSLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIV 172

Query: 576  WQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKIC 635
            WQLL    +   + ++Y  L+   SP +  I RDI RT+P H++FK+    GQ+ L+ + 
Sbjct: 173  WQLLCSAQSMP-IKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVM 231

Query: 636  KAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKF 695
            KAYS+ D E+GYCQG +F+  +LL+ MPEE+AF V VK+M DY LRELFK +  +L    
Sbjct: 232  KAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCM 291

Query: 696  YQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISV 755
            YQ E ++QE++P+L+ HF   S    MYAS WFLT+F   FPL +   I D+ + EG+ +
Sbjct: 292  YQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEI 351

Query: 756  IFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLK 815
            +F V L LL+ ++ +L+  D EG L+ F+  +P ++    +  KL++ A  +K + KK+K
Sbjct: 352  VFRVGLALLQMNQAELMQLDMEGMLQHFQKVIPHQFDGVPD--KLIQAAYQVKYNSKKMK 409

Query: 816  KYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLD 875
            K EKEY T++ ++ +++  I+R   ENR L++    LE+      +              
Sbjct: 410  KLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRIETLEKHKCSSNYN------------- 456

Query: 876  NAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIG 935
              E+    L KEL+  + +L +AE +          LKEM  + LD     I+K ++ + 
Sbjct: 457  --EDFVLQLEKELV--QARLSEAESQ--------CALKEMQDKVLD-----IEKRNNSLP 499

Query: 936  DYKQICSQLSERL---EKQQTANKVEIEKIRQKVDDCER--CREFFNKEGRVKGISSTKE 990
            D   I ++L E L   + ++    + ++++RQ+V D E    R      GR K     K+
Sbjct: 500  DENNI-ARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHLARTTGRWK--DPPKK 556

Query: 991  VLDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLGLALNEV 1042
                +  +E  T++ +  E + E+ + K +++E E + Q   +HL  A  EV
Sbjct: 557  NAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEV 608



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 36/164 (21%), Positives = 72/164 (43%), Gaps = 13/164 (7%)

Query: 788 PKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQE 847
           PK+    E   +LM +      +Q ++++ ++    M  Q     + + R E+E   LQE
Sbjct: 554 PKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEVISLQE 613

Query: 848 ANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLM-TKQKLIDAEEEKRRLE 906
               L  +N  L  +L  +K          + + +  NKE +M  + +  D+      L 
Sbjct: 614 KVQYLSAQNKGLLTQLSEAK--------RKQAEIECKNKEEVMAVRLREADSIAAVAELR 665

Query: 907 EESAQLKEMCRRELDKAESEIKKNSS--IIGDYKQICSQLSERL 948
           +  A+L+   ++E  K + ++ K+ S   IG+ K   ++L+  L
Sbjct: 666 QHIAELE--IQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHEL 707


>gi|229577000 ecotropic viral integration site 5-like isoform 1 [Homo
            sapiens]
          Length = 805

 Score =  266 bits (680), Expect = 8e-71
 Identities = 166/509 (32%), Positives = 264/509 (51%), Gaps = 40/509 (7%)

Query: 524  SGSGDVSKECAEKILE--------TWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEV 575
            SGS  VS   A   L          WG + ++W      + K L  L+R G+P   R  V
Sbjct: 65   SGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIV 124

Query: 576  WQLLAGCHNNDHLVE-KYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKI 634
            WQLL  C   D  V+ +Y  L+   SP +  I RDI RT+P H++FK     GQ+ L+ +
Sbjct: 125  WQLL--CSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNV 182

Query: 635  CKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCK 694
             KAYS+ D E+GYCQG +F+  +LL+ MPEE+AF V V++M +Y LRELFK +  +L   
Sbjct: 183  MKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLC 242

Query: 695  FYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGIS 754
             YQ E ++QE +PDL  HF   S    MYAS WFLTLF   FPL +   + D+ + EG+ 
Sbjct: 243  IYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLE 302

Query: 755  VIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKL 814
            ++F V L LL+ ++ +L+  D EG  ++F+  +P ++ S  +  KL+  A  +K + KK+
Sbjct: 303  IVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPD--KLVLKAYQVKYNPKKM 360

Query: 815  KKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDL 874
            K+ EKEY  M+ ++ +++  I+R   ENR L++    LE+E+  LA  L+  ++   ++ 
Sbjct: 361  KRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKESAALADRLIQGQVTRAQE- 419

Query: 875  DNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSII 934
              AEE    + +EL + +Q+   A E+ ++ +    QL+E             ++N  + 
Sbjct: 420  --AEENY-VIKRELAVVRQQCSSAAEDLQKAQSTIRQLQEQ------------QENPRLT 464

Query: 935  GDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCERCREFFNKEGRVKGISSTKEVLDE 994
             D+        E+   ++T     + +++ KV D E+       E  V  +         
Sbjct: 465  EDFVSHLETELEQSRLRETETLGALREMQDKVLDMEKRNSSLPDENNVAQL--------- 515

Query: 995  DTDEEKETLKNQLREMELELAQTKLQLVE 1023
               EE + LK +  +      + KLQL E
Sbjct: 516  --QEELKALKVREGQAVASTRELKLQLQE 542


>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
            sapiens]
          Length = 794

 Score =  258 bits (659), Expect = 2e-68
 Identities = 179/554 (32%), Positives = 285/554 (51%), Gaps = 45/554 (8%)

Query: 524  SGSGDVSKECAEKILE--------TWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEV 575
            SGS  VS   A   L          WG + ++W      + K L  L+R G+P   R  V
Sbjct: 65   SGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIV 124

Query: 576  WQLLAGCHNNDHLVE-KYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKI 634
            WQLL  C   D  V+ +Y  L+   SP +  I RDI RT+P H++FK     GQ+ L+ +
Sbjct: 125  WQLL--CSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNV 182

Query: 635  CKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCK 694
             KAYS+ D E+GYCQG +F+  +LL+ MPEE+AF V V++M +Y LRELFK +  +L   
Sbjct: 183  MKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLC 242

Query: 695  FYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGIS 754
             YQ E ++QE +PDL  HF   S    MYAS WFLTLF   FPL +   + D+ + EG+ 
Sbjct: 243  IYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLE 302

Query: 755  VIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKL 814
            ++F V L LL+ ++ +L+  D EG  ++F+  +P ++ S  +  KL+  A  +K + KK+
Sbjct: 303  IVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPD--KLVLKAYQVKYNPKKM 360

Query: 815  KKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDL 874
            K+ EKEY  M+ ++ +++  I+R   ENR L++    LE+     A E       ++++L
Sbjct: 361  KRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKGQVTRAQE-AEENYVIKREL 419

Query: 875  DNAEEKADALNKELLMTKQKL--IDAEEEKRRLEE----------ESAQLKEM----CRR 918
                ++  +  ++L   +  +  +  ++E  RL E          E ++L+E       R
Sbjct: 420  AVVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRLRETETLGALR 479

Query: 919  ELDKAESEIKKNSSIIGDYKQICSQLSERL------EKQQTANKVEIEKIRQKVDDCERC 972
            E+     +++K +S + D   + +QL E L      E Q  A+  E++   Q++ D  + 
Sbjct: 480  EMQDKVLDMEKRNSSLPDENNV-AQLQEELKALKVREGQAVASTRELKLQLQELSDTWQA 538

Query: 973  REFFNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLE 1032
                 + GR K  S  K V+ E  D   E +  +LRE +      +L+    E + QD  
Sbjct: 539  H--LARGGRWKE-SPRKLVVGELQD---ELMSVRLREAQALAEGRELRQRVVELETQDHI 592

Query: 1033 HHLGLALNEVQAAK 1046
            H     LN V+A +
Sbjct: 593  HR--NLLNRVEAER 604


>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
          Length = 1298

 Score =  232 bits (592), Expect = 1e-60
 Identities = 154/458 (33%), Positives = 244/458 (53%), Gaps = 35/458 (7%)

Query: 478  ESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKE----C 533
            + E   ER+K+    S+       Q  ++    E+ + E + + L S    +  E    C
Sbjct: 826  DPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGAC 885

Query: 534  AEKILETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEK-- 591
             +++L TW + L      +    + + +L++ GVP++ RGE+WQ LA  +   H +    
Sbjct: 886  QKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQ 945

Query: 592  ------YRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEI 645
                  Y+ L+ + + Q  AI  D+ RTFP H YF    G GQ SL+ + KAYS+ D+E+
Sbjct: 946  QPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEV 1005

Query: 646  GYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEY 705
            GYCQG SF+A VLLLHM EEQAF +L  +M+D G R+ ++ +   L  + YQL RL+ +Y
Sbjct: 1006 GYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDY 1065

Query: 706  IPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLK 765
              DLYNH  +  +   +YA+ WFLTLF ++F L  V  + D++  +G  VIF VAL LL 
Sbjct: 1066 HRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLL- 1124

Query: 766  TSKDDLLL--TDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHT 823
            +S++ L++    FE  ++F +  LP    SE   +K++     M IS K+L  YE EYH 
Sbjct: 1125 SSQETLIMECESFENIVEFLKNTLPDMNTSE--MEKIITQVFEMDIS-KQLHAYEVEYHV 1181

Query: 824  MREQ------QAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNA 877
            ++++        +  + +E+ ER N +L+  NM L  E   +AH   T   AL  +L+N 
Sbjct: 1182 LQDELQESSYSCEDSETLEKLERANSQLKRQNMDL-LEKLQVAH---TKIQALESNLEN- 1236

Query: 878  EEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEM 915
                  L +E  M K  +   E+EK   ++   QL+++
Sbjct: 1237 -----LLTRETKM-KSLIRTLEQEKMAYQKTVEQLRKL 1268


>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
            [Homo sapiens]
          Length = 1168

 Score =  216 bits (551), Expect = 7e-56
 Identities = 137/402 (34%), Positives = 213/402 (52%), Gaps = 25/402 (6%)

Query: 533  CAEKILETWGELLSK-WHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEK 591
            C +++   W ++LS      +    +++ S V  GVP   RGE+W+ LA   +  H    
Sbjct: 766  CLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPS 825

Query: 592  --------YRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDE 643
                    Y+ L+ + + Q  AI  D+ RTFP H YF    G GQ SLY I KAYS+ D+
Sbjct: 826  KQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQ 885

Query: 644  EIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQ 703
            E+GYCQG SF+A +LLLHM EE+AF +L  +MFD GLR+ ++ +   L  + YQL RL+ 
Sbjct: 886  EVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLH 945

Query: 704  EYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGL 763
            +Y  DLYNH  +  +   +YA+ WFLT+F ++FPL  V  + D++  +G  VIF VAL L
Sbjct: 946  DYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSL 1005

Query: 764  LKTSKDDLLL-TDFEGALKFFRVQLPK--RYRSEENAKKLMELACNMKISQKKLKKYEKE 820
            L + K  +L   + E  + F +  LP     + E+   ++ E+        K+L+ YE E
Sbjct: 1006 LGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDI-----AKQLQAYEVE 1060

Query: 821  YHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHEL------VTSKIALRKDL 874
            YH ++E+      P+   +R + +L++ N  L ++N DL  +L      + S  A  + L
Sbjct: 1061 YHVLQEELI-DSSPLSDNQRMD-KLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKL 1118

Query: 875  DNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMC 916
             ++E K       L + +  L+   EE RR   E +  +  C
Sbjct: 1119 LSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPEC 1160


>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
          Length = 508

 Score =  140 bits (354), Expect = 5e-33
 Identities = 80/233 (34%), Positives = 123/233 (52%), Gaps = 14/233 (6%)

Query: 541 WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAG----CHNNDHLVEKYRILI 596
           W ++L+ W   +  + K++    + G+P +LRG  WQ L+G       N    ++  +  
Sbjct: 86  WLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDM-- 143

Query: 597 TKESPQD----SAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQS 652
              SP D      I RD++R FP H+ F   GG GQ  L+++ KAY++Y  E GYCQ Q+
Sbjct: 144 ---SPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQA 200

Query: 653 FLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNH 712
            +AAVLL+HMP EQAF  LV+I   Y L   + +  E +      L  L+Q+  P  + H
Sbjct: 201 PIAAVLLMHMPAEQAFWCLVQICEKY-LPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKH 259

Query: 713 FLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLK 765
                ++  +Y ++WF+  F+   P   V  + D+  CEG+ +IF V L LLK
Sbjct: 260 LSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLK 312


>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
          Length = 808

 Score =  138 bits (347), Expect = 3e-32
 Identities = 79/231 (34%), Positives = 124/231 (53%), Gaps = 10/231 (4%)

Query: 541 WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKY--RILITK 598
           W ++ S W   L+ R +++    R G+P +LR + WQ L+   N+  L+E+   +    +
Sbjct: 335 WLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLS---NSKELLEQNPGKFEELE 391

Query: 599 ESPQD----SAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFL 654
            +P D      I +D++R FP H+ F   GG GQ  LY+I KAY++Y  + GYCQ Q+ +
Sbjct: 392 RAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPV 451

Query: 655 AAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFL 714
           AAVLL+HMP EQAF  LV+I   Y L   +    E +         L++   P  + H  
Sbjct: 452 AAVLLMHMPAEQAFWCLVQICDKY-LPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLR 510

Query: 715 DISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLK 765
              ++  +Y ++WF+ +F    P   V  + D+  CEG+ +IF VAL LL+
Sbjct: 511 RQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLR 561


>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
          Length = 446

 Score =  135 bits (341), Expect = 2e-31
 Identities = 80/230 (34%), Positives = 117/230 (50%), Gaps = 8/230 (3%)

Query: 541 WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHN-NDHLVEKYRILITKE 599
           W E+ S W   ++ R K++    R G+P ALR   W LL G H    +    Y+ L   E
Sbjct: 67  WVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELA--E 124

Query: 600 SPQD----SAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLA 655
           +P D      I RD++R FP H+ F    G GQ  L ++ KAY++Y  E GYCQ Q  +A
Sbjct: 125 APGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVA 184

Query: 656 AVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLD 715
           AVLL+H+P E+AF  LV+I   Y L   +  + E +         L++  +P ++ H   
Sbjct: 185 AVLLMHLPPEEAFWCLVQICEVY-LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQ 243

Query: 716 ISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLK 765
           + +   +Y  +WFL LF    P   V  + D  L EG  V+F V L L++
Sbjct: 244 VGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVR 293


>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
          Length = 828

 Score =  125 bits (313), Expect = 3e-28
 Identities = 88/310 (28%), Positives = 146/310 (47%), Gaps = 19/310 (6%)

Query: 541 WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKE- 599
           W ++L  W    N   ++    +  G+P  LRGEVW LL        + E+ R L +K  
Sbjct: 77  WLKMLKGWEKYKNT--EKFHRRIYKGIPLQLRGEVWALLLEIPK---MKEETRDLYSKLK 131

Query: 600 ------SPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSF 653
                 SP    I  D+NRTF  H  F+D  G  Q SL+ +  AYS+Y+ E+GYCQG S 
Sbjct: 132 HRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQ 191

Query: 654 LAAVLLLHMPEEQAFSVLVKIMF--DYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYN 711
           + A+LL++M EE AF  LVK+     + +   F Q F  L       E+++ +++  L  
Sbjct: 192 ITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQ 251

Query: 712 HFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDL 771
           H     +    Y  +WF   F  + P  +   I D+ + EG  V+  ++  +LK  K  L
Sbjct: 252 HLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHL 311

Query: 772 LLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQ 831
           +    E  ++FF+  L K +  E++      +   ++IS  +LK+ + +     ++    
Sbjct: 312 MKLSMEELVEFFQETLAKDFFFEDDF-----VIEQLQISMTELKRAKLDLPEPGKEDEYP 366

Query: 832 EDPIERFERE 841
           + P+ +   E
Sbjct: 367 KKPLGQLPPE 376


>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
          Length = 845

 Score =  125 bits (313), Expect = 3e-28
 Identities = 88/310 (28%), Positives = 146/310 (47%), Gaps = 19/310 (6%)

Query: 541 WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKE- 599
           W ++L  W    N   ++    +  G+P  LRGEVW LL        + E+ R L +K  
Sbjct: 94  WLKMLKGWEKYKNT--EKFHRRIYKGIPLQLRGEVWALLLEIPK---MKEETRDLYSKLK 148

Query: 600 ------SPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSF 653
                 SP    I  D+NRTF  H  F+D  G  Q SL+ +  AYS+Y+ E+GYCQG S 
Sbjct: 149 HRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQ 208

Query: 654 LAAVLLLHMPEEQAFSVLVKIMF--DYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYN 711
           + A+LL++M EE AF  LVK+     + +   F Q F  L       E+++ +++  L  
Sbjct: 209 ITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQ 268

Query: 712 HFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDL 771
           H     +    Y  +WF   F  + P  +   I D+ + EG  V+  ++  +LK  K  L
Sbjct: 269 HLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHL 328

Query: 772 LLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQ 831
           +    E  ++FF+  L K +  E++      +   ++IS  +LK+ + +     ++    
Sbjct: 329 MKLSMEELVEFFQETLAKDFFFEDDF-----VIEQLQISMTELKRAKLDLPEPGKEDEYP 383

Query: 832 EDPIERFERE 841
           + P+ +   E
Sbjct: 384 KKPLGQLPPE 393


>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
           isoform a [Homo sapiens]
          Length = 1120

 Score =  112 bits (281), Expect = 1e-24
 Identities = 76/250 (30%), Positives = 127/250 (50%), Gaps = 11/250 (4%)

Query: 530 SKECAEKILE-TWGELLSKWHLNLNV-RPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDH 587
           SK   EK+ E +W  L ++    +++ R K+   LV  G+PE LRGE+W L +G  N+  
Sbjct: 449 SKMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMA 508

Query: 588 LVEKYRILITKESP-----QDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYD 642
               Y   + ++S          I RD+ R+ P H  F+     G  +L ++  AY+  +
Sbjct: 509 TNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSD--TGISALRRVLTAYAYRN 566

Query: 643 EEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLM 702
            +IGYCQ  + L +VLLL+  EE+AF +LV +  +  L + F +            E L+
Sbjct: 567 PKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVC-ERMLPDYFNRRIIGALVDQAVFEELI 625

Query: 703 QEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALG 762
           ++++P L  H  D++  + +  S WFLTLF +  P+    +++D    +GI  I  + L 
Sbjct: 626 RDHLPQLTEHMTDMTFFSSVSLS-WFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLA 684

Query: 763 LLKTSKDDLL 772
           +L  + D LL
Sbjct: 685 ILDYNLDKLL 694


>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
           sapiens]
          Length = 1266

 Score =  112 bits (279), Expect = 2e-24
 Identities = 74/226 (32%), Positives = 118/226 (52%), Gaps = 15/226 (6%)

Query: 555 RPKQLSSLVRNGVPEALRGEVWQLLAGCHNN--------DHLVEKYRILITKESPQDSAI 606
           R ++   LV  G+PE++RGE+W LL+G  N         + LVEK    + K +     I
Sbjct: 504 RTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKS---MGKYNLATEEI 560

Query: 607 TRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQ 666
            RD++R+ P H  F++  G    +L ++  AY+  +  IGYCQ  + + +VLLL+  EE+
Sbjct: 561 ERDLHRSLPEHPAFQNEMGIA--ALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEE 618

Query: 667 AFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQ 726
           AF +LV +  +  L + +              E L ++Y+P LY+   D+ + + +  S 
Sbjct: 619 AFWLLVALC-ERMLPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTISLS- 676

Query: 727 WFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLL 772
           WFLTLF +  P      ++D    EGI VIF +AL +L  + D LL
Sbjct: 677 WFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLL 722


>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
          Length = 775

 Score =  108 bits (271), Expect = 2e-23
 Identities = 78/276 (28%), Positives = 124/276 (44%), Gaps = 27/276 (9%)

Query: 543 ELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNN----------DHLVEKY 592
           E+L  W +  + R  ++  L   G+P ++RG+VW L  G   N              E++
Sbjct: 463 EILPNWEVMRSTR--RVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERW 520

Query: 593 RILITKESPQDSA-------------ITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYS 639
           +      S  D+              I  DI+RTFP+  Y    GG   D L+ I  AY+
Sbjct: 521 KSFSETSSENDTEGVSVADREASLELIKLDISRTFPSL-YIFQKGGPYHDVLHSILGAYT 579

Query: 640 VYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLE 699
            Y  ++GY QG SF+AAVL+L++ E  AF     ++        F+ +   +   F   E
Sbjct: 580 CYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFE 639

Query: 700 RLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNV 759
              +E +  L+ HF   SL   +Y   W  TL++   PL +   + D+   +G   +F  
Sbjct: 640 VFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRT 699

Query: 760 ALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEE 795
            LG+L+  +D LL  DF    +F   +LP+   SE+
Sbjct: 700 GLGILRLYEDILLQMDFIHIAQFL-TKLPEDITSEK 734


>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
          Length = 1140

 Score =  108 bits (269), Expect = 4e-23
 Identities = 73/235 (31%), Positives = 123/235 (52%), Gaps = 21/235 (8%)

Query: 555 RPKQLSSLVRNGVPEALRGEVWQLLAGCHNN--------DHLVEKYR---ILITKESPQD 603
           R +++  LV  G+PE+LRG +W L +    +         +LVE+      L+T+E    
Sbjct: 494 RTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEE---- 549

Query: 604 SAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMP 663
             I RD++R+ P H  F++  G    +L ++  AY+  + +IGYCQ  + L +VLLL+  
Sbjct: 550 --IERDLHRSLPEHPAFQNETGIA--ALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTK 605

Query: 664 EEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMY 723
           EE+AF +LV +  +  L + F              E L++ ++P+L  H  D+S  A + 
Sbjct: 606 EEEAFWLLVAVC-ERMLPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSALASVS 664

Query: 724 ASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEG 778
            S WFLTLF +  PL    +++D    +GI  IF + L +L+ + +DL  +  +G
Sbjct: 665 LS-WFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDG 718


>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
          Length = 413

 Score =  107 bits (266), Expect = 8e-23
 Identities = 93/361 (25%), Positives = 147/361 (40%), Gaps = 29/361 (8%)

Query: 460 KQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDND 519
           KQ  RKN          L  E          +   +  +   +  V+ +   + +E    
Sbjct: 17  KQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRR 76

Query: 520 EPLLSGSGDVSKECAEKILETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLL 579
           +  L     V +     +L    E+L  W      R  ++  L   G+P ++RG+VW L 
Sbjct: 77  KKQLEERCRVEESIGNAVLTWNNEILPNWETMWCSR--KVRDLWWQGIPPSVRGKVWSLA 134

Query: 580 AGCHNN----------DHLVEKYRILITKESPQDSA---------------ITRDINRTF 614
            G   N              E++R L T  S  ++                I  DI+RTF
Sbjct: 135 IGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTF 194

Query: 615 PAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKI 674
           P    F+  GG   D L+ I  AY+ Y  ++GY QG SF+AAVL+L++    AF     +
Sbjct: 195 PNLCIFQQ-GGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNL 253

Query: 675 MFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTA 734
           +        F+ +   +   F   E   +E +P L+ HF   +L   +Y   W  TL++ 
Sbjct: 254 LNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSK 313

Query: 735 KFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSE 794
             PL +   I D+   +G   +F  ALG+LK  +D L   DF    +F   +LP+   +E
Sbjct: 314 SLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFL-TRLPEDLPAE 372

Query: 795 E 795
           E
Sbjct: 373 E 373


>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score =  107 bits (266), Expect = 8e-23
 Identities = 93/361 (25%), Positives = 147/361 (40%), Gaps = 29/361 (8%)

Query: 460 KQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDND 519
           KQ  RKN          L  E          +   +  +   +  V+ +   + +E    
Sbjct: 297 KQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRR 356

Query: 520 EPLLSGSGDVSKECAEKILETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLL 579
           +  L     V +     +L    E+L  W      R  ++  L   G+P ++RG+VW L 
Sbjct: 357 KKQLEERCRVEESIGNAVLTWNNEILPNWETMWCSR--KVRDLWWQGIPPSVRGKVWSLA 414

Query: 580 AGCHNN----------DHLVEKYRILITKESPQDSA---------------ITRDINRTF 614
            G   N              E++R L T  S  ++                I  DI+RTF
Sbjct: 415 IGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTF 474

Query: 615 PAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKI 674
           P    F+  GG   D L+ I  AY+ Y  ++GY QG SF+AAVL+L++    AF     +
Sbjct: 475 PNLCIFQQ-GGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNL 533

Query: 675 MFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTA 734
           +        F+ +   +   F   E   +E +P L+ HF   +L   +Y   W  TL++ 
Sbjct: 534 LNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSK 593

Query: 735 KFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSE 794
             PL +   I D+   +G   +F  ALG+LK  +D L   DF    +F   +LP+   +E
Sbjct: 594 SLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFL-TRLPEDLPAE 652

Query: 795 E 795
           E
Sbjct: 653 E 653


>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score =  107 bits (266), Expect = 8e-23
 Identities = 93/361 (25%), Positives = 147/361 (40%), Gaps = 29/361 (8%)

Query: 460 KQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDND 519
           KQ  RKN          L  E          +   +  +   +  V+ +   + +E    
Sbjct: 297 KQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRR 356

Query: 520 EPLLSGSGDVSKECAEKILETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLL 579
           +  L     V +     +L    E+L  W      R  ++  L   G+P ++RG+VW L 
Sbjct: 357 KKQLEERCRVEESIGNAVLTWNNEILPNWETMWCSR--KVRDLWWQGIPPSVRGKVWSLA 414

Query: 580 AGCHNN----------DHLVEKYRILITKESPQDSA---------------ITRDINRTF 614
            G   N              E++R L T  S  ++                I  DI+RTF
Sbjct: 415 IGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTF 474

Query: 615 PAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKI 674
           P    F+  GG   D L+ I  AY+ Y  ++GY QG SF+AAVL+L++    AF     +
Sbjct: 475 PNLCIFQQ-GGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNL 533

Query: 675 MFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTA 734
           +        F+ +   +   F   E   +E +P L+ HF   +L   +Y   W  TL++ 
Sbjct: 534 LNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSK 593

Query: 735 KFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSE 794
             PL +   I D+   +G   +F  ALG+LK  +D L   DF    +F   +LP+   +E
Sbjct: 594 SLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFL-TRLPEDLPAE 652

Query: 795 E 795
           E
Sbjct: 653 E 653


>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
          Length = 749

 Score =  107 bits (266), Expect = 8e-23
 Identities = 72/258 (27%), Positives = 121/258 (46%), Gaps = 8/258 (3%)

Query: 555 RPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAIT-----RD 609
           R ++L SLV  G+P  +R ++W  L+G        E     I K S  D  I      +D
Sbjct: 103 RSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKD 162

Query: 610 INRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFS 669
           + RT P++  F   G  G   L ++ +A +    EIGYCQG   +AA LLL + EE AF 
Sbjct: 163 LLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFW 222

Query: 670 VLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFL 729
           ++  I+ D      F      +      L  L+ +Y+P L     +  +E  +    WFL
Sbjct: 223 MMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFL 282

Query: 730 TLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPK 789
           T F +   + ++  I DL   EG  V+F + LG+L   +++L+ ++   ++      +P 
Sbjct: 283 TAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPS 342

Query: 790 RYRSEENAKKLMELACNM 807
           +    E+A+ L+ +A  +
Sbjct: 343 QM---EDAELLLGVAMRL 357


>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
          Length = 963

 Score =  107 bits (266), Expect = 8e-23
 Identities = 84/317 (26%), Positives = 140/317 (44%), Gaps = 24/317 (7%)

Query: 558 QLSSLVRNGVPEALRGEVWQLLAGCHNND--------HLVEKYRILITKESPQDSAITRD 609
           +L +L+R G+P   R +VW+     H           H     +  + K++P    I  D
Sbjct: 654 ELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELD 713

Query: 610 INRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFS 669
           + RT P + ++     +G   L  +  A+S  + +IGYCQG + L AV LL++ +E AF 
Sbjct: 714 LLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFW 773

Query: 670 VLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFL 729
            LV I+  +  R+ + +              LM E +P L+ HF    ++  +    WFL
Sbjct: 774 CLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFL 833

Query: 730 TLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLL-LTDFEGALKFFRVQLP 788
            +F       ++F I D  L EG  VIF  AL L K  ++++L L D     K+ R    
Sbjct: 834 VVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFT- 892

Query: 789 KRYRSEENAKKLMELACN-------MKISQKKLKKYEKEYHTMREQQAQQEDPIERFERE 841
              R+  +A+KL+ ++          +I  ++    EK    + E +A +ED    F RE
Sbjct: 893 ---RTILDARKLISISFGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIRED----FLRE 945

Query: 842 NRRLQEANMRLEQENDD 858
                +    +  E +D
Sbjct: 946 RDTSPDKGELVSDEEED 962



 Score = 32.3 bits (72), Expect = 2.5
 Identities = 21/99 (21%), Positives = 46/99 (46%), Gaps = 1/99 (1%)

Query: 946  ERLEKQQTANKVEIEKIRQKVDDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKETLKN 1005
            E+L+K  ++ K E+ ++ Q+     +  ++F      +G+      L    D++   L +
Sbjct: 352  EQLKKDLSSQK-ELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTS 410

Query: 1006 QLREMELELAQTKLQLVEAECKIQDLEHHLGLALNEVQA 1044
            QL    LE    + ++   + K+ +L   LG+ +  +QA
Sbjct: 411  QLERFSLEKESLQQEVRTLKSKVGELNEQLGMLMETIQA 449


>gi|45597177 TBC1 domain family, member 9B (with GRAM domain)
           isoform b [Homo sapiens]
          Length = 1233

 Score =  105 bits (263), Expect = 2e-22
 Identities = 94/338 (27%), Positives = 149/338 (44%), Gaps = 34/338 (10%)

Query: 468 TDTLYEVVCLESESERERRKTTASPSVR---LPQSGSQSSVIPSPPEDDEEEDNDEPLLS 524
           +D L +    +  S   R+ +   PS      PQ GS+    P+ P    +    +   +
Sbjct: 391 SDFLQKTPSKQPGSIGSRKASVVDPSTESSPAPQEGSEQPASPASPLSSRQSFCAQEAPT 450

Query: 525 GSGDVSKECAEKI-LETWGELLSK-------WHLNL--------NVRPKQLSSLVRNGVP 568
            S  + K   +   +E  G   +K       WH++           R  +  +LV  G+P
Sbjct: 451 ASQGLLKLFQKNSPMEDLGAKGAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIP 510

Query: 569 EALRGEVWQLLAGCHNN--------DHLVEKYRILITKESPQDSAITRDINRTFPAHDYF 620
           E+LRGE+W L +G  N           LVEK      K S     I RD++R+ P H  F
Sbjct: 511 ESLRGELWLLFSGAWNEMVTHPGYYAELVEKST---GKYSLATEEIERDLHRSMPEHPAF 567

Query: 621 KDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGL 680
           ++  G    +L ++  AY+  +  IGYCQ  + + +VLLL+  EE+AF +LV +  +  L
Sbjct: 568 QNELGIA--ALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALC-ERML 624

Query: 681 RELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYM 740
            + +              E L ++++P L     D+ + + +  S WFLTLF +  P   
Sbjct: 625 PDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSISLS-WFLTLFLSVMPFES 683

Query: 741 VFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEG 778
              I+D    EGI VI  VAL +L  + + LL    EG
Sbjct: 684 AVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEG 721


>gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
           isoform a [Homo sapiens]
          Length = 1250

 Score =  105 bits (263), Expect = 2e-22
 Identities = 94/338 (27%), Positives = 149/338 (44%), Gaps = 34/338 (10%)

Query: 468 TDTLYEVVCLESESERERRKTTASPSVR---LPQSGSQSSVIPSPPEDDEEEDNDEPLLS 524
           +D L +    +  S   R+ +   PS      PQ GS+    P+ P    +    +   +
Sbjct: 391 SDFLQKTPSKQPGSIGSRKASVVDPSTESSPAPQEGSEQPASPASPLSSRQSFCAQEAPT 450

Query: 525 GSGDVSKECAEKI-LETWGELLSK-------WHLNL--------NVRPKQLSSLVRNGVP 568
            S  + K   +   +E  G   +K       WH++           R  +  +LV  G+P
Sbjct: 451 ASQGLLKLFQKNSPMEDLGAKGAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIP 510

Query: 569 EALRGEVWQLLAGCHNN--------DHLVEKYRILITKESPQDSAITRDINRTFPAHDYF 620
           E+LRGE+W L +G  N           LVEK      K S     I RD++R+ P H  F
Sbjct: 511 ESLRGELWLLFSGAWNEMVTHPGYYAELVEKST---GKYSLATEEIERDLHRSMPEHPAF 567

Query: 621 KDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGL 680
           ++  G    +L ++  AY+  +  IGYCQ  + + +VLLL+  EE+AF +LV +  +  L
Sbjct: 568 QNELGIA--ALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALC-ERML 624

Query: 681 RELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYM 740
            + +              E L ++++P L     D+ + + +  S WFLTLF +  P   
Sbjct: 625 PDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSISLS-WFLTLFLSVMPFES 683

Query: 741 VFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEG 778
              I+D    EGI VI  VAL +L  + + LL    EG
Sbjct: 684 AVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEG 721


>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
          Length = 914

 Score =  104 bits (260), Expect = 4e-22
 Identities = 68/236 (28%), Positives = 109/236 (46%), Gaps = 9/236 (3%)

Query: 558 QLSSLVRNGVPEALRGEVWQLLAGCHNND--------HLVEKYRILITKESPQDSAITRD 609
           +L +L+R G+P   R +VW+     H           H     +  + K++P    I  D
Sbjct: 654 ELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELD 713

Query: 610 INRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFS 669
           + RT P + ++     +G   L  +  A+S  + +IGYCQG + L AV LL++ +E AF 
Sbjct: 714 LLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFW 773

Query: 670 VLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFL 729
            LV I+  +  R+ + +              LM E +P L+ HF    ++  +    WFL
Sbjct: 774 CLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFL 833

Query: 730 TLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLL-LTDFEGALKFFR 784
            +F       ++F I D  L EG  VIF  AL L K  ++++L L D     K+ R
Sbjct: 834 VVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLR 889



 Score = 32.3 bits (72), Expect = 2.5
 Identities = 21/99 (21%), Positives = 46/99 (46%), Gaps = 1/99 (1%)

Query: 946  ERLEKQQTANKVEIEKIRQKVDDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKETLKN 1005
            E+L+K  ++ K E+ ++ Q+     +  ++F      +G+      L    D++   L +
Sbjct: 352  EQLKKDLSSQK-ELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTS 410

Query: 1006 QLREMELELAQTKLQLVEAECKIQDLEHHLGLALNEVQA 1044
            QL    LE    + ++   + K+ +L   LG+ +  +QA
Sbjct: 411  QLERFSLEKESLQQEVRTLKSKVGELNEQLGMLMETIQA 449


>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
          Length = 336

 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 65/222 (29%), Positives = 107/222 (48%), Gaps = 4/222 (1%)

Query: 555 RPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKY--RILITKESPQ-DSAITRDIN 611
           R + +   VR GVP   R  VW +L+G          Y  ++L  + +P+ + AI  D+N
Sbjct: 57  RSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLN 116

Query: 612 RTFPAHDYFKDTGGDG-QDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSV 670
           RTFP +  F+ T     Q +LY +  AY  +++ +GYCQG +F+A  L+L    E+    
Sbjct: 117 RTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFW 176

Query: 671 LVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLT 730
           L+  +    L + +      L      L  L++  +P +      + +   +  S+WF+ 
Sbjct: 177 LLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFIC 236

Query: 731 LFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLL 772
           LF    P+  V  I D L  EG  +IF VAL L+K  ++ +L
Sbjct: 237 LFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELIL 278


>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
          Length = 917

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 79/303 (26%), Positives = 132/303 (43%), Gaps = 27/303 (8%)

Query: 558 QLSSLVRNGVPEALRGEVWQLLAGCH-NNDHLVEKYRILITK----ESPQDSAITRDINR 612
           +L  L+R GVP   R  VW+ L      + H    Y+ L+++    E P    I  D+NR
Sbjct: 617 ELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNR 676

Query: 613 TFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQ-AFSVL 671
           TFP + +F        D L ++  A+S  +  IGYCQG + LAA+ LL + EE+ AF  L
Sbjct: 677 TFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCL 736

Query: 672 VKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTL 731
           V I+      + +             L+ L+ E +P L  H     ++  +    WFL +
Sbjct: 737 VAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVV 796

Query: 732 FTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRY 791
           F       ++  + D  L EG        L L    ++ L +  +   L+FF        
Sbjct: 797 FADSLISNILLRVWDAFLYEGTKYNEKEILRL----QNGLEIYQY---LRFFT------- 842

Query: 792 RSEENAKKLMELACN-------MKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRR 844
           ++  N++KLM +A N        ++ Q ++   E+    +RE +  + + +ER     R 
Sbjct: 843 KTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASRRRA 902

Query: 845 LQE 847
           + E
Sbjct: 903 VSE 905


>gi|34147456 TBC domain-containing protein kinase-like [Homo
           sapiens]
          Length = 830

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 66/234 (28%), Positives = 102/234 (43%), Gaps = 11/234 (4%)

Query: 555 RPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESP--QDSAITRDINR 612
           +  Q+    R  +P  +RG  W  L G     H   KY   I K++P   D  I  DI R
Sbjct: 392 KKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHA--KYDA-IDKDTPIPTDRQIEVDIPR 448

Query: 613 TFPAHDYFKDTGG-DGQDSLYKICKAYSVYDEEIGYCQG-QSFLAAVLLLHMPEEQ-AFS 669
               H Y +     +G     ++ KA+ V   ++ Y QG  S  A  L L+   E  A++
Sbjct: 449 ---CHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYA 505

Query: 670 VLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFL 729
            +   +  Y      K N   +        +++  + P+L NH  +I     +YA  WFL
Sbjct: 506 CMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFL 565

Query: 730 TLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFF 783
           T+FT  FPL+ +FH+ D LL    S  F + + +L+  +D LL   F   +  F
Sbjct: 566 TMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLF 619


>gi|38570103 TBC1 domain family, member 8B (with GRAM domain)
           isoform b [Homo sapiens]
          Length = 632

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 51/152 (33%), Positives = 81/152 (53%), Gaps = 9/152 (5%)

Query: 530 SKECAEKILE-TWGELLSKWHLNLNV-RPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDH 587
           SK   EK+ E +W  L ++    +++ R K+   LV  G+PE LRGE+W L +G  N+  
Sbjct: 449 SKMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMA 508

Query: 588 LVEKYRILITKESP-----QDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYD 642
               Y   + ++S          I RD+ R+ P H  F+     G  +L ++  AY+  +
Sbjct: 509 TNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSD--TGISALRRVLTAYAYRN 566

Query: 643 EEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKI 674
            +IGYCQ  + L +VLLL+  EE+AF +LV +
Sbjct: 567 PKIGYCQAMNILTSVLLLYAKEEEAFWLLVAV 598


>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
          Length = 1406

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 48/140 (34%), Positives = 71/140 (50%), Gaps = 8/140 (5%)

Query: 541 WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKES 600
           W E+L +W    +    +L   V  G+P  +RG VW +L        L    R  I KE 
Sbjct: 77  WMEMLGEWETYKH--SSKLIDRVYKGIPMNIRGPVWSVLLNIQEIK-LKNPGRYQIMKER 133

Query: 601 PQDSA-----ITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLA 655
            + S+     I  D+  T   H +F+D  G  Q  L+ I  AYS Y+ E+GYC+  S + 
Sbjct: 134 GKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHIT 193

Query: 656 AVLLLHMPEEQAFSVLVKIM 675
           A+ LL++PEE AF  LV+++
Sbjct: 194 ALFLLYLPEEDAFWALVQLL 213


>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
          Length = 549

 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 48/140 (34%), Positives = 71/140 (50%), Gaps = 8/140 (5%)

Query: 541 WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKES 600
           W ++L  W    + R  +L      G+P  +RG +W +L        L    R  I KE 
Sbjct: 78  WVDMLGDWEKYKSSR--KLIDRAYKGMPMNIRGPMWSVLLNIEEMK-LKNPGRYQIMKEK 134

Query: 601 PQDSA-----ITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLA 655
            + S+     I RDI+ T   H +F+D  G  Q  L  I  AY  Y+ E+GYC+  S +A
Sbjct: 135 GKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIA 194

Query: 656 AVLLLHMPEEQAFSVLVKIM 675
           A+ LL++PEE AF  LV+++
Sbjct: 195 ALFLLYLPEEDAFWALVQLL 214


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,165,820
Number of Sequences: 37866
Number of extensions: 1949220
Number of successful extensions: 15687
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 270
Number of HSP's successfully gapped in prelim test: 1011
Number of HSP's that attempted gapping in prelim test: 8646
Number of HSP's gapped (non-prelim): 4617
length of query: 1069
length of database: 18,247,518
effective HSP length: 113
effective length of query: 956
effective length of database: 13,968,660
effective search space: 13354038960
effective search space used: 13354038960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.