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Search of human proteins with 16418467
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]
(347 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens] 699 0.0
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 134 9e-32
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 116 3e-26
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 116 3e-26
gi|194440719 chondroadherin-like [Homo sapiens] 114 1e-25
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ... 112 6e-25
gi|225579152 insulin-like growth factor binding protein, acid la... 110 2e-24
gi|4826772 insulin-like growth factor binding protein, acid labi... 110 2e-24
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 109 3e-24
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 109 3e-24
gi|150417978 platelet glycoprotein Ib alpha polypeptide precurso... 107 2e-23
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 106 3e-23
gi|12007646 nyctalopin precursor [Homo sapiens] 105 6e-23
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 101 9e-22
gi|153251229 chondroadherin precursor [Homo sapiens] 100 2e-21
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 100 3e-21
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 100 3e-21
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 98 1e-20
gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo s... 97 2e-20
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho... 97 2e-20
gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 96 6e-20
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 95 1e-19
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 94 2e-19
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 94 2e-19
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 93 4e-19
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 92 7e-19
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 92 9e-19
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens] 91 1e-18
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 91 2e-18
gi|88702793 slit-like 2 [Homo sapiens] 91 2e-18
>gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]
Length = 347
Score = 699 bits (1803), Expect = 0.0
Identities = 347/347 (100%), Positives = 347/347 (100%)
Query: 1 MSSWSRQRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA 60
MSSWSRQRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA
Sbjct: 1 MSSWSRQRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA 60
Query: 61 EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRV 120
EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRV
Sbjct: 61 EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRV 120
Query: 121 LDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLP 180
LDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLP
Sbjct: 121 LDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLP 180
Query: 181 PGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRY 240
PGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRY
Sbjct: 181 PGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRY 240
Query: 241 LFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNP 300
LFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNP
Sbjct: 241 LFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNP 300
Query: 301 WICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKSQ 347
WICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKSQ
Sbjct: 301 WICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKSQ 347
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 134 bits (338), Expect = 9e-32
Identities = 99/292 (33%), Positives = 138/292 (47%), Gaps = 30/292 (10%)
Query: 80 LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQAS 139
L LP L Q + L+ L+L+ N L L E P+ L+ L L+ NAL+GLP G+F
Sbjct: 157 LQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKL 216
Query: 140 ATLDTLVLKEN-----------QLEVLEVSWLH-------------GLKALGHLDLSGNR 175
+L L L N QL LE WL L L L L N
Sbjct: 217 GSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNM 276
Query: 176 LRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQ 235
LR LP GL A+ L L L NQLET+ L L L N + L +
Sbjct: 277 LRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDL 336
Query: 236 PDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFD 295
+L L+L N L + FQ L +L++L LS N L ++PEG++ N+++ +
Sbjct: 337 EELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIF----DTNYNLFN-LA 391
Query: 296 ISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKSQ 347
+ GNPW CD +L+ L+ WLQ D++ + T CAGP +KGQ + A+ + Q
Sbjct: 392 LHGNPWQCDCHLAYLFNWLQQYTDRLLN-IQTYCAGPAYLKGQVVPALNEKQ 442
Score = 92.0 bits (227), Expect = 7e-19
Identities = 76/228 (33%), Positives = 102/228 (44%), Gaps = 1/228 (0%)
Query: 56 CQPPAEIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPV 115
CQ + G LP L V + +L N+ + L +L L+ N LE+L + +
Sbjct: 86 CQFRPDAFGGLPR-LEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHL 144
Query: 116 PQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNR 175
L L L N L LP LFQ L TL L +N L L H L +L L LS N
Sbjct: 145 AALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNA 204
Query: 176 LRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQ 235
L LP G+ L+ L L N + LPP + LERL L+ N + L +
Sbjct: 205 LSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASL 264
Query: 236 PDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASL 283
+L +L L N L + AG F L L L++N L +V EG +A L
Sbjct: 265 GNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHL 312
Score = 89.7 bits (221), Expect = 3e-18
Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 11/262 (4%)
Query: 26 LLLLAASAWGVTLSPKDC---QVFRSDHGSSISCQPPAEIPGYLPADTVHLAVEFFNLTH 82
LLLLA A + DC +VF SD + A +P +P T ++ + T
Sbjct: 12 LLLLARPAQPCPMGC-DCFVQEVFCSD-------EELATVPLDIPPYTKNIIFVETSFTT 63
Query: 83 LPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATL 142
L L ++ + L P+ +P+L L++T ++ L +F +L
Sbjct: 64 LETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSL 123
Query: 143 DTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLET 202
L L N LE L L AL L L GN+L+ LP L T L+TL+L +N L
Sbjct: 124 GKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQ 183
Query: 203 LPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQL 262
LP +L L+ L L N L L + + L+ LFL+ N ++ + F L L
Sbjct: 184 LPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCL 243
Query: 263 DMLDLSNNSLASVPEGLWASLG 284
+ L L N++ +P ++ASLG
Sbjct: 244 ERLWLQRNAITHLPLSIFASLG 265
Score = 87.4 bits (215), Expect = 2e-17
Identities = 66/201 (32%), Positives = 92/201 (45%), Gaps = 1/201 (0%)
Query: 116 PQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNR 175
P + + + T L F ++ L +V QL GL L L+++G+
Sbjct: 49 PYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSS 108
Query: 176 LRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQ 235
L + +N T L L L N LE LP L + LE LHL+GN+LQ L + L P
Sbjct: 109 FLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPL 168
Query: 236 PDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFD 295
L+ L L N LA++ F L L L LSNN+L+ +P+G++ LG D +
Sbjct: 169 THLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNN 228
Query: 296 ISGNPWICDQNLSDLYR-WLQ 315
IS P L L R WLQ
Sbjct: 229 ISELPPQVFSQLFCLERLWLQ 249
Score = 57.0 bits (136), Expect = 2e-08
Identities = 48/153 (31%), Positives = 65/153 (42%), Gaps = 24/153 (15%)
Query: 73 LAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLP 132
L++++ L LPA L L L L+ N LE+++ + LR L L+ NA+T LP
Sbjct: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329
Query: 133 PGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRT 192
G+F+ L+ L L L N L L P L N + L
Sbjct: 330 AGIFR------------------------DLEELVKLYLGSNNLTALHPALFQNLSKLEL 365
Query: 193 LDLGENQLETLPPDLLRGPLQLERLHLEGNKLQ 225
L L +NQL TLP + L L L GN Q
Sbjct: 366 LSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQ 398
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 116 bits (290), Expect = 3e-26
Identities = 77/264 (29%), Positives = 123/264 (46%), Gaps = 5/264 (1%)
Query: 80 LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQAS 139
LT +P G LQEL L N + LSP L+ L L+ N ++ LPP +F
Sbjct: 215 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 274
Query: 140 ATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQ 199
L+ L L N L+ L + + L L L N + LP + +N L+ L L NQ
Sbjct: 275 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQ 334
Query: 200 LETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGL 259
+ + P G +L L L N LQ L ++ +L+ + L N+L ++ F +
Sbjct: 335 ISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV 394
Query: 260 RQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKD 319
L + L NN L ++P G++ LG+ ++R + NPW CD ++ L WL +
Sbjct: 395 NGLMAIQLQNNQLENLPLGIFDHLGK-LCELR----LYDNPWRCDSDILPLRNWLLLNQP 449
Query: 320 KMFSQNDTRCAGPEAVKGQTLLAV 343
++ + C P V+GQ+L+ +
Sbjct: 450 RLGTDTVPVCFSPANVRGQSLIII 473
Score = 104 bits (259), Expect = 1e-22
Identities = 97/352 (27%), Positives = 154/352 (43%), Gaps = 48/352 (13%)
Query: 24 FLLLLLAASAWGVTLS----PKDCQVFRSDHGSSISCQPP--AEIPGYLPADTVHLAVEF 77
+LLLL+ AWG L+ P +C R+ S + C +P LP + + L +
Sbjct: 12 YLLLLVGCQAWGAGLAYHGCPSECTCSRA---SQVECTGARIVAVPTPLPWNAMSLQILN 68
Query: 78 FNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQ 137
++T L + S L L + N L ++P R + LR L L N L LP GLFQ
Sbjct: 69 THITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQ 128
Query: 138 ASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGL------LANFTL-- 189
+L++L+L NQL ++ + L L L GN L +P G L L
Sbjct: 129 GLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGK 188
Query: 190 ----------------LRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLL 233
L+ L L EN+L +P G + L+ L L+ N++ +L L
Sbjct: 189 NSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFH 248
Query: 234 PQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDG 293
+L+ L+L+ N ++++ F L QL+ L L NSL + G++ + PN +R+
Sbjct: 249 NNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPM--PN--LRE- 303
Query: 294 FDISGNPWICDQNLSDL----YRWLQAQKDKMFSQNDTRCAGPEAVKGQTLL 341
W+ D ++S L + L+ + + S+N P A G T L
Sbjct: 304 ------LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTEL 349
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 116 bits (290), Expect = 3e-26
Identities = 77/264 (29%), Positives = 123/264 (46%), Gaps = 5/264 (1%)
Query: 80 LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQAS 139
LT +P G LQEL L N + LSP L+ L L+ N ++ LPP +F
Sbjct: 209 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 268
Query: 140 ATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQ 199
L+ L L N L+ L + + L L L N + LP + +N L+ L L NQ
Sbjct: 269 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQ 328
Query: 200 LETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGL 259
+ + P G +L L L N LQ L ++ +L+ + L N+L ++ F +
Sbjct: 329 ISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV 388
Query: 260 RQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKD 319
L + L NN L ++P G++ LG+ ++R + NPW CD ++ L WL +
Sbjct: 389 NGLMAIQLQNNQLENLPLGIFDHLGK-LCELR----LYDNPWRCDSDILPLRNWLLLNQP 443
Query: 320 KMFSQNDTRCAGPEAVKGQTLLAV 343
++ + C P V+GQ+L+ +
Sbjct: 444 RLGTDTVPVCFSPANVRGQSLIII 467
Score = 104 bits (259), Expect = 1e-22
Identities = 97/352 (27%), Positives = 154/352 (43%), Gaps = 48/352 (13%)
Query: 24 FLLLLLAASAWGVTLS----PKDCQVFRSDHGSSISCQPP--AEIPGYLPADTVHLAVEF 77
+LLLL+ AWG L+ P +C R+ S + C +P LP + + L +
Sbjct: 6 YLLLLVGCQAWGAGLAYHGCPSECTCSRA---SQVECTGARIVAVPTPLPWNAMSLQILN 62
Query: 78 FNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQ 137
++T L + S L L + N L ++P R + LR L L N L LP GLFQ
Sbjct: 63 THITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQ 122
Query: 138 ASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGL------LANFTL-- 189
+L++L+L NQL ++ + L L L GN L +P G L L
Sbjct: 123 GLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGK 182
Query: 190 ----------------LRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLL 233
L+ L L EN+L +P G + L+ L L+ N++ +L L
Sbjct: 183 NSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFH 242
Query: 234 PQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDG 293
+L+ L+L+ N ++++ F L QL+ L L NSL + G++ + PN +R+
Sbjct: 243 NNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPM--PN--LRE- 297
Query: 294 FDISGNPWICDQNLSDL----YRWLQAQKDKMFSQNDTRCAGPEAVKGQTLL 341
W+ D ++S L + L+ + + S+N P A G T L
Sbjct: 298 ------LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTEL 343
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 114 bits (286), Expect = 1e-25
Identities = 111/351 (31%), Positives = 141/351 (40%), Gaps = 35/351 (9%)
Query: 17 PHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPAEIPGYLPADTVHLAVE 76
P V L LLLL A P+ C S + Q E+P +P T L ++
Sbjct: 11 PLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQ 70
Query: 77 FFNLTHLPANLLQGASKLQEL------------------------HLSSNGLESLSPEFL 112
L +PA QG L L +L+SN L L E L
Sbjct: 71 GNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEAL 130
Query: 113 RPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLS 172
+ LR L+L NAL L PG F A L TL L N L L GL + L LS
Sbjct: 131 DGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLS 190
Query: 173 GNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLL 232
N L L P LA LR L L N+L+ LP +L L RL L N L G++
Sbjct: 191 HNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDG 250
Query: 233 LPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRD 292
L P LR L L+G L + AF +L LDL N L ++P L P R
Sbjct: 251 LALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP-----PLQGPGQLRR- 304
Query: 293 GFDISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAV 343
+ GNP C L WL + ++D C GP ++G+ L A+
Sbjct: 305 -LRLQGNPLWCGCQARPLLEWLARAR----VRSDGACQGPRRLRGEALDAL 350
Score = 103 bits (258), Expect = 2e-22
Identities = 94/325 (28%), Positives = 141/325 (43%), Gaps = 25/325 (7%)
Query: 40 PKDCQ-VFRSDHGSSISCQPPAEIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELH 98
P+ C V S H S C A +P P+DT L + + +P G L LH
Sbjct: 397 PRACVCVPESRHSSCEGCGLQA-VPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455
Query: 99 LSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVS 158
L G+ L L + +L L L+ N L GL + + L L L+ N+ + +
Sbjct: 456 LQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGA 515
Query: 159 WLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLH 218
L L +L L L N + +L PG L LR + L N++ + L +LE+LH
Sbjct: 516 ALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLH 575
Query: 219 LEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGL-RQLDMLDLSNNSLASVPE 277
L+ N+L+ + L P L L L+GN L + GAFQ + R L L L+++ L +
Sbjct: 576 LDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICP 635
Query: 278 GLWASLGQ------------------PNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKD 319
G ++ LG P+ + D+S NP+ CD L L+RWL
Sbjct: 636 GAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNL 695
Query: 320 KMFSQNDTRCAGPEAVKGQTLLAVA 344
++ CA P +GQ + A A
Sbjct: 696 RV----GATCATPPNARGQRVKAAA 716
>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
sapiens]
Length = 581
Score = 112 bits (279), Expect = 6e-25
Identities = 91/349 (26%), Positives = 157/349 (44%), Gaps = 41/349 (11%)
Query: 25 LLLLLAASAWGVTLSPKDCQVFRSDHGSSISC--QPPAEIPGYLPADTVHLAVEFFNLTH 82
LL +L+++ G PK C+ G + C Q EIP + A + L++ + +L
Sbjct: 23 LLTMLSSAERGC---PKGCRC----EGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQK 75
Query: 83 LPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATL 142
L N +G ++L L+L N + ++ + +L+ L L+ N ++ F+ L
Sbjct: 76 LKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNL 135
Query: 143 DTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLET 202
L L NQL L GL+ L L L N LR +P + + L LDLG N++ +
Sbjct: 136 RNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRS 195
Query: 203 LPPDLLRGPLQLERLHLE------------------------GNKLQVLGKDLLLPQPDL 238
L ++ G ++L+ LHLE NK+ V+G+ + L
Sbjct: 196 LARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSL 255
Query: 239 RYLFLNGNKL-ARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDIS 297
+ L L+GN++ A FQ + L L+L +N L + + + S W + ++
Sbjct: 256 QRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDS-----WISLNDISLA 310
Query: 298 GNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKS 346
GN W C +N+ L WL++ K +N CA P+ ++G ++ K+
Sbjct: 311 GNIWECSRNICSLVNWLKSFKG--LRENTIICASPKELQGVNVIDAVKN 357
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 110 bits (274), Expect = 2e-24
Identities = 79/222 (35%), Positives = 109/222 (49%)
Query: 62 IPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVL 121
+P +P T L ++ NL+ +P Q S L L+L L SL P+ L + L L
Sbjct: 106 LPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHL 165
Query: 122 DLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPP 181
L RN L L G F + L +L L N+L LE GL +L L+L N L LP
Sbjct: 166 HLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPD 225
Query: 182 GLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYL 241
LR L L N+L L P L G +L L L N L+ + ++ + P L+ L
Sbjct: 226 AAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKL 285
Query: 242 FLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASL 283
+L+ N +A VA GAF GL+ L LDLS+N +A + E + L
Sbjct: 286 YLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGL 327
Score = 101 bits (251), Expect = 1e-21
Identities = 71/207 (34%), Positives = 101/207 (48%)
Query: 79 NLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQA 138
+L LP +G L+EL L+ N L L P + +LR LDL+RNAL + +F
Sbjct: 219 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQ 278
Query: 139 SATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGEN 198
L L L N + + GLKAL LDLS NR+ L LR L L N
Sbjct: 279 LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 338
Query: 199 QLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQG 258
+ +L P + LE L L N+++ L + L L L+ N+L V AGAF G
Sbjct: 339 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 398
Query: 259 LRQLDMLDLSNNSLASVPEGLWASLGQ 285
L + +++LS N L ++PE ++ LG+
Sbjct: 399 LTNVAVMNLSGNCLRNLPEQVFRGLGK 425
Score = 99.8 bits (247), Expect = 3e-21
Identities = 75/225 (33%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 51 GSSISCQPPAEIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPE 110
G+++S PPA ++L + L L L G L LHL N L SL+
Sbjct: 121 GNNLSSVPPAAFQNLSSLGFLNL--QGGQLGSLEPQALLGLENLCHLHLERNQLRSLALG 178
Query: 111 FLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLD 170
P L L L+ N L+ L GLF+ +L L L N L VL + GL +L L
Sbjct: 179 TFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELV 238
Query: 171 LSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKD 230
L+GNRL L P L + LR LDL N L + ++ +L++L+L+ N + +
Sbjct: 239 LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPG 298
Query: 231 LLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASV 275
L LR+L L+ N++A + F GL L +L LS+N++AS+
Sbjct: 299 AFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 343
Score = 88.6 bits (218), Expect = 8e-18
Identities = 90/328 (27%), Positives = 132/328 (40%), Gaps = 61/328 (18%)
Query: 74 AVEFFNLTH-----LPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNAL 128
A+ + +L+H L + G L+ L LS N + SL P + + L L L N +
Sbjct: 305 ALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRI 364
Query: 129 TGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLP-------- 180
L F+ L+ L L NQL+ ++ GL + ++LSGN LR LP
Sbjct: 365 RQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLG 424
Query: 181 ----------------PGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKL 224
P + LR L L +N L + L G +L L L N+L
Sbjct: 425 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 484
Query: 225 QVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLG 284
L L L YL L+ N+LA + A A L++ LD+S+N L ++P L A LG
Sbjct: 485 THLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLG 544
Query: 285 Q---------------PNWDMRDGFDISGNPWICD-----------QNLSDLYRWLQA-- 316
+ P + + GNPW C QN S + R++QA
Sbjct: 545 RLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAIC 604
Query: 317 ----QKDKMFSQNDTRCAGPEAVKGQTL 340
+ ++ N+ CA P V G L
Sbjct: 605 EGDDCQPPAYTYNNITCASPPEVVGLDL 632
Score = 87.8 bits (216), Expect = 1e-17
Identities = 64/196 (32%), Positives = 93/196 (47%)
Query: 90 GASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKE 149
G L+ L LS N + L + + LRVL L+ NA+ L P F+ L+ L L
Sbjct: 302 GLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGH 361
Query: 150 NQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLR 209
N++ L GL L L L N+L+++ G T + ++L N L LP + R
Sbjct: 362 NRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFR 421
Query: 210 GPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSN 269
G +L LHLEG+ L + LR LFL N L + + GL +L LDL++
Sbjct: 422 GLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTS 481
Query: 270 NSLASVPEGLWASLGQ 285
N L +P L+ LG+
Sbjct: 482 NQLTHLPHRLFQGLGK 497
Score = 80.9 bits (198), Expect = 2e-15
Identities = 82/262 (31%), Positives = 110/262 (41%), Gaps = 32/262 (12%)
Query: 72 HLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGL 131
HL +E L L L L LS+N L L + L L+L N+L L
Sbjct: 164 HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 223
Query: 132 PPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLR--------KLP--- 180
P F+ +L LVL N+L L+ + GL L LDLS N LR +LP
Sbjct: 224 PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ 283
Query: 181 -------------PGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVL 227
PG LR LDL N++ L D G L L L L N + L
Sbjct: 284 KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 343
Query: 228 GKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPN 287
L L L N++ ++A +F+GL QL++L L +N L V G A LG N
Sbjct: 344 RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAG--AFLGLTN 401
Query: 288 WDMRDGFDISGNPWICDQNLSD 309
+ ++SGN C +NL +
Sbjct: 402 VAV---MNLSGN---CLRNLPE 417
Score = 70.9 bits (172), Expect = 2e-12
Identities = 45/114 (39%), Positives = 60/114 (52%)
Query: 171 LSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKD 230
L GN L +PP N + L L+L QL +L P L G L LHLE N+L+ L
Sbjct: 119 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALG 178
Query: 231 LLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLG 284
P L L L+ N+L+R+ G F+GL L L+L NSLA +P+ + LG
Sbjct: 179 TFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLG 232
Score = 61.2 bits (147), Expect = 1e-09
Identities = 59/191 (30%), Positives = 79/191 (41%), Gaps = 28/191 (14%)
Query: 117 QLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSG--- 173
+L V +RN LT LP G+ L L N L + + L +LG L+L G
Sbjct: 93 ELSVFCSSRN-LTRLPDGV---PGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQL 148
Query: 174 ---------------------NRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPL 212
N+LR L G A+ L +L L N+L L L G
Sbjct: 149 GSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLG 208
Query: 213 QLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSL 272
L L+L N L VL LR L L GN+LA + F GL +L LDLS N+L
Sbjct: 209 SLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNAL 268
Query: 273 ASVPEGLWASL 283
++ ++ L
Sbjct: 269 RAIKANVFVQL 279
Score = 55.8 bits (133), Expect = 5e-08
Identities = 41/124 (33%), Positives = 61/124 (49%), Gaps = 4/124 (3%)
Query: 172 SGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDL 231
S L +LP G+ + L L N L ++PP + L L+L+G +L L
Sbjct: 99 SSRNLTRLPDGVPGG---TQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQA 155
Query: 232 LLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMR 291
LL +L +L L N+L +A G F L L LSNN L+ + +GL+ LG WD+
Sbjct: 156 LLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGS-LWDLN 214
Query: 292 DGFD 295
G++
Sbjct: 215 LGWN 218
Score = 52.8 bits (125), Expect = 5e-07
Identities = 37/102 (36%), Positives = 47/102 (46%), Gaps = 7/102 (6%)
Query: 68 ADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNA 127
A+ + L + LTHLP L QG KL+ L LS N L L + L P+ + LD++ N
Sbjct: 472 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 531
Query: 128 LTGLPPGLFQASATLDTLVLKENQLEV-------LEVSWLHG 162
L LP L L L L+ N L LE WL G
Sbjct: 532 LEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEG 573
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 110 bits (274), Expect = 2e-24
Identities = 79/222 (35%), Positives = 109/222 (49%)
Query: 62 IPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVL 121
+P +P T L ++ NL+ +P Q S L L+L L SL P+ L + L L
Sbjct: 68 LPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHL 127
Query: 122 DLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPP 181
L RN L L G F + L +L L N+L LE GL +L L+L N L LP
Sbjct: 128 HLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPD 187
Query: 182 GLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYL 241
LR L L N+L L P L G +L L L N L+ + ++ + P L+ L
Sbjct: 188 AAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKL 247
Query: 242 FLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASL 283
+L+ N +A VA GAF GL+ L LDLS+N +A + E + L
Sbjct: 248 YLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGL 289
Score = 101 bits (251), Expect = 1e-21
Identities = 71/207 (34%), Positives = 101/207 (48%)
Query: 79 NLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQA 138
+L LP +G L+EL L+ N L L P + +LR LDL+RNAL + +F
Sbjct: 181 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQ 240
Query: 139 SATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGEN 198
L L L N + + GLKAL LDLS NR+ L LR L L N
Sbjct: 241 LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 300
Query: 199 QLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQG 258
+ +L P + LE L L N+++ L + L L L+ N+L V AGAF G
Sbjct: 301 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 360
Query: 259 LRQLDMLDLSNNSLASVPEGLWASLGQ 285
L + +++LS N L ++PE ++ LG+
Sbjct: 361 LTNVAVMNLSGNCLRNLPEQVFRGLGK 387
Score = 99.8 bits (247), Expect = 3e-21
Identities = 75/225 (33%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 51 GSSISCQPPAEIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPE 110
G+++S PPA ++L + L L L G L LHL N L SL+
Sbjct: 83 GNNLSSVPPAAFQNLSSLGFLNL--QGGQLGSLEPQALLGLENLCHLHLERNQLRSLALG 140
Query: 111 FLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLD 170
P L L L+ N L+ L GLF+ +L L L N L VL + GL +L L
Sbjct: 141 TFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELV 200
Query: 171 LSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKD 230
L+GNRL L P L + LR LDL N L + ++ +L++L+L+ N + +
Sbjct: 201 LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPG 260
Query: 231 LLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASV 275
L LR+L L+ N++A + F GL L +L LS+N++AS+
Sbjct: 261 AFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 305
Score = 88.6 bits (218), Expect = 8e-18
Identities = 90/328 (27%), Positives = 132/328 (40%), Gaps = 61/328 (18%)
Query: 74 AVEFFNLTH-----LPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNAL 128
A+ + +L+H L + G L+ L LS N + SL P + + L L L N +
Sbjct: 267 ALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRI 326
Query: 129 TGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLP-------- 180
L F+ L+ L L NQL+ ++ GL + ++LSGN LR LP
Sbjct: 327 RQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLG 386
Query: 181 ----------------PGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKL 224
P + LR L L +N L + L G +L L L N+L
Sbjct: 387 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 446
Query: 225 QVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLG 284
L L L YL L+ N+LA + A A L++ LD+S+N L ++P L A LG
Sbjct: 447 THLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLG 506
Query: 285 Q---------------PNWDMRDGFDISGNPWICD-----------QNLSDLYRWLQA-- 316
+ P + + GNPW C QN S + R++QA
Sbjct: 507 RLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAIC 566
Query: 317 ----QKDKMFSQNDTRCAGPEAVKGQTL 340
+ ++ N+ CA P V G L
Sbjct: 567 EGDDCQPPAYTYNNITCASPPEVVGLDL 594
Score = 87.8 bits (216), Expect = 1e-17
Identities = 64/196 (32%), Positives = 93/196 (47%)
Query: 90 GASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKE 149
G L+ L LS N + L + + LRVL L+ NA+ L P F+ L+ L L
Sbjct: 264 GLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGH 323
Query: 150 NQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLR 209
N++ L GL L L L N+L+++ G T + ++L N L LP + R
Sbjct: 324 NRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFR 383
Query: 210 GPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSN 269
G +L LHLEG+ L + LR LFL N L + + GL +L LDL++
Sbjct: 384 GLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTS 443
Query: 270 NSLASVPEGLWASLGQ 285
N L +P L+ LG+
Sbjct: 444 NQLTHLPHRLFQGLGK 459
Score = 80.9 bits (198), Expect = 2e-15
Identities = 82/262 (31%), Positives = 110/262 (41%), Gaps = 32/262 (12%)
Query: 72 HLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGL 131
HL +E L L L L LS+N L L + L L+L N+L L
Sbjct: 126 HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 185
Query: 132 PPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLR--------KLP--- 180
P F+ +L LVL N+L L+ + GL L LDLS N LR +LP
Sbjct: 186 PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ 245
Query: 181 -------------PGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVL 227
PG LR LDL N++ L D G L L L L N + L
Sbjct: 246 KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 305
Query: 228 GKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPN 287
L L L N++ ++A +F+GL QL++L L +N L V G A LG N
Sbjct: 306 RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAG--AFLGLTN 363
Query: 288 WDMRDGFDISGNPWICDQNLSD 309
+ ++SGN C +NL +
Sbjct: 364 VAV---MNLSGN---CLRNLPE 379
Score = 70.9 bits (172), Expect = 2e-12
Identities = 45/114 (39%), Positives = 60/114 (52%)
Query: 171 LSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKD 230
L GN L +PP N + L L+L QL +L P L G L LHLE N+L+ L
Sbjct: 81 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALG 140
Query: 231 LLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLG 284
P L L L+ N+L+R+ G F+GL L L+L NSLA +P+ + LG
Sbjct: 141 TFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLG 194
Score = 61.2 bits (147), Expect = 1e-09
Identities = 59/191 (30%), Positives = 79/191 (41%), Gaps = 28/191 (14%)
Query: 117 QLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSG--- 173
+L V +RN LT LP G+ L L N L + + L +LG L+L G
Sbjct: 55 ELSVFCSSRN-LTRLPDGV---PGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQL 110
Query: 174 ---------------------NRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPL 212
N+LR L G A+ L +L L N+L L L G
Sbjct: 111 GSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLG 170
Query: 213 QLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSL 272
L L+L N L VL LR L L GN+LA + F GL +L LDLS N+L
Sbjct: 171 SLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNAL 230
Query: 273 ASVPEGLWASL 283
++ ++ L
Sbjct: 231 RAIKANVFVQL 241
Score = 55.8 bits (133), Expect = 5e-08
Identities = 41/124 (33%), Positives = 61/124 (49%), Gaps = 4/124 (3%)
Query: 172 SGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDL 231
S L +LP G+ + L L N L ++PP + L L+L+G +L L
Sbjct: 61 SSRNLTRLPDGVPGG---TQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQA 117
Query: 232 LLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMR 291
LL +L +L L N+L +A G F L L LSNN L+ + +GL+ LG WD+
Sbjct: 118 LLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGS-LWDLN 176
Query: 292 DGFD 295
G++
Sbjct: 177 LGWN 180
Score = 52.8 bits (125), Expect = 5e-07
Identities = 37/102 (36%), Positives = 47/102 (46%), Gaps = 7/102 (6%)
Query: 68 ADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNA 127
A+ + L + LTHLP L QG KL+ L LS N L L + L P+ + LD++ N
Sbjct: 434 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 493
Query: 128 LTGLPPGLFQASATLDTLVLKENQLEV-------LEVSWLHG 162
L LP L L L L+ N L LE WL G
Sbjct: 494 LEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEG 535
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 109 bits (273), Expect = 3e-24
Identities = 90/340 (26%), Positives = 153/340 (45%), Gaps = 35/340 (10%)
Query: 22 TLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA--EIPGYLPADTVHLAVEFFN 79
TL L++L A PK+C+ G + C+ A +IP + + L++ F +
Sbjct: 21 TLLLVMLTGAQR----ACPKNCRC----DGKIVYCESHAFADIPENISGGSQGLSLRFNS 72
Query: 80 LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQAS 139
+ L +N G ++L L+L N + S+ + + + +L+ L L+ N +T L F
Sbjct: 73 IQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPV 132
Query: 140 ATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQ 199
L L L N+L+ L+ GL+ L L L N L+ +P + + L LDLG N+
Sbjct: 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNR 192
Query: 200 LETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGL 259
L +L + G L+L+ LHLE N+ + +LR ++L N++ ++ G
Sbjct: 193 LRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTW 252
Query: 260 RQLDMLDLSNNSLASVPEGLWASLGQPN---------------------WDMRDGFDISG 298
L LDLS N + + G + L PN W +SG
Sbjct: 253 SSLHNLDLSGNDIQGIEPGTFKCL--PNLQKLNLDSNKLTNISQETVNAWISLISITLSG 310
Query: 299 NPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQ 338
N W C +++ L+ WL+ K ++ CAGP+ ++G+
Sbjct: 311 NMWECSRSICPLFYWLKNFKGN--KESTMICAGPKHIQGE 348
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 109 bits (273), Expect = 3e-24
Identities = 90/340 (26%), Positives = 153/340 (45%), Gaps = 35/340 (10%)
Query: 22 TLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA--EIPGYLPADTVHLAVEFFN 79
TL L++L A PK+C+ G + C+ A +IP + + L++ F +
Sbjct: 21 TLLLVMLTGAQR----ACPKNCRC----DGKIVYCESHAFADIPENISGGSQGLSLRFNS 72
Query: 80 LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQAS 139
+ L +N G ++L L+L N + S+ + + + +L+ L L+ N +T L F
Sbjct: 73 IQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPV 132
Query: 140 ATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQ 199
L L L N+L+ L+ GL+ L L L N L+ +P + + L LDLG N+
Sbjct: 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNR 192
Query: 200 LETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGL 259
L +L + G L+L+ LHLE N+ + +LR ++L N++ ++ G
Sbjct: 193 LRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTW 252
Query: 260 RQLDMLDLSNNSLASVPEGLWASLGQPN---------------------WDMRDGFDISG 298
L LDLS N + + G + L PN W +SG
Sbjct: 253 SSLHNLDLSGNDIQGIEPGTFKCL--PNLQKLNLDSNKLTNISQETVNAWISLISITLSG 310
Query: 299 NPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQ 338
N W C +++ L+ WL+ K ++ CAGP+ ++G+
Sbjct: 311 NMWECSRSICPLFYWLKNFKGN--KESTMICAGPKHIQGE 348
>gi|150417978 platelet glycoprotein Ib alpha polypeptide precursor
[Homo sapiens]
Length = 639
Score = 107 bits (267), Expect = 2e-23
Identities = 85/244 (34%), Positives = 115/244 (47%), Gaps = 36/244 (14%)
Query: 79 NLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQA 138
NLT LP +L + + L HLS N L + S L P +L L+L R LT L Q
Sbjct: 37 NLTALPPDLPKDTTIL---HLSENLLYTFSLATLMPYTRLTQLNLDRCELTKL-----QV 88
Query: 139 SATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGEN 198
TL L G LDLS N+L+ LP L L LD+ N
Sbjct: 89 DGTLPVL---------------------GTLDLSHNQLQSLPL-LGQTLPALTVLDVSFN 126
Query: 199 QLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQG 258
+L +LP LRG +L+ L+L+GN+L+ L LL P P L L L N L + AG G
Sbjct: 127 RLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNG 186
Query: 259 LRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQK 318
L LD L L NSL ++P+G + S + + GNPW+C+ + RWLQ
Sbjct: 187 LENLDTLLLQENSLYTIPKGFFGS------HLLPFAFLHGNPWLCNCEILYFRRWLQDNA 240
Query: 319 DKMF 322
+ ++
Sbjct: 241 ENVY 244
Score = 75.9 bits (185), Expect = 5e-14
Identities = 48/107 (44%), Positives = 59/107 (55%), Gaps = 11/107 (10%)
Query: 66 LPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTR 125
LPA TV L V F LT LP L+G +LQEL+L N L++L P L P P+L L L
Sbjct: 115 LPALTV-LDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLAN 173
Query: 126 NALTGLPPGLFQASATLDTLVLKENQL----------EVLEVSWLHG 162
N LT LP GL LDTL+L+EN L +L ++LHG
Sbjct: 174 NNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHG 220
>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
Length = 420
Score = 106 bits (265), Expect = 3e-23
Identities = 100/325 (30%), Positives = 142/325 (43%), Gaps = 39/325 (12%)
Query: 25 LLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPP--AEIPGYLPADTVHLAVEFFNLTH 82
LLL+L A P C + S ++SCQ + +P LP T
Sbjct: 17 LLLMLLALPLAAPSCPMLCTCYSSP--PTVSCQANNFSSVPLSLPPST------------ 62
Query: 83 LPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATL 142
Q L L +N + +L P L L L N L+ + PG F+ L
Sbjct: 63 ------------QRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQAL 108
Query: 143 DTLVLKENQ-LEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLE 201
+ L L +N+ L LE GL+ L L L +L LP + L+ L L EN L
Sbjct: 109 EELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLL 168
Query: 202 TLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQ 261
L DL L L L GN+L++L + + L L L+GN+L V AF+GL +
Sbjct: 169 HLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSR 228
Query: 262 LDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKM 321
L +L L NNSLAS+P A L P+ + ++ NPW CD L+ W Q +
Sbjct: 229 LTILYLFNNSLASLPGEALADL--PSLEF---LRLNANPWACDCRARPLWAWFQRAR--- 280
Query: 322 FSQNDTRCAGPEAVKGQTLLAVAKS 346
S +D CA P +G+ L A+ ++
Sbjct: 281 VSSSDVTCATPPERQGRDLRALREA 305
>gi|12007646 nyctalopin precursor [Homo sapiens]
Length = 481
Score = 105 bits (262), Expect = 6e-23
Identities = 109/383 (28%), Positives = 154/383 (40%), Gaps = 70/383 (18%)
Query: 21 RTLFLLLLLAA-----SAWGV----TLSPKDCQVFRSDHGSSISC------QPPAEIP-- 63
R + +LLL A SAW V P C + G S+ C + PAE+P
Sbjct: 4 RGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCE 63
Query: 64 -------------------GYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNG- 103
G LP+ L++ NL+ + +G +L EL L+ NG
Sbjct: 64 AVSIDLDRNGLRFLGERAFGTLPS-LRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGD 122
Query: 104 LESLSPEFLRPVPQLRVLDLTRNALTGLP-----------------------PGLFQASA 140
L L + +LR LDL L +P PG + A
Sbjct: 123 LRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLA 182
Query: 141 TLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQL 200
L L+ ++E + S L GL+ L L L NR+R + G + +L L L +N L
Sbjct: 183 NLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLL 242
Query: 201 ETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLR 260
LP D RG +L L+L GN L + + +L L+L+ N +A V GAFQ L
Sbjct: 243 AELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLS 302
Query: 261 QLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDK 320
L L L+ N L + W + QP + + F + NPW CD L L W++
Sbjct: 303 GLLALHLNGNRLTVL---AWVAF-QPGFFLGRLF-LFRNPWCCDCRLEWLRDWMEGSG-- 355
Query: 321 MFSQNDTRCAGPEAVKGQTLLAV 343
D CA P +V G L V
Sbjct: 356 --RVTDVPCASPGSVAGLDLSQV 376
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 101 bits (252), Expect = 9e-22
Identities = 101/353 (28%), Positives = 141/353 (39%), Gaps = 71/353 (20%)
Query: 62 IPGYLPADTVHLAVEFFN---LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQL 118
+PG L V L F + L + N+ Q LQEL L+ N L+ L + L
Sbjct: 113 LPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENL 172
Query: 119 RVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRK 178
++LDL+ N LT LP GL A A L+ L+L N+L L+ L+ L AL L N +R
Sbjct: 173 KLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRS 232
Query: 179 LPPGLLANFTLLRTLDLGENQLETLP-----------------------PDLLRGPL-QL 214
+ PG L +L L N L LP P +L G + L
Sbjct: 233 IAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGL 292
Query: 215 ERLHLEGNKLQVLGKDLLLPQPDLRYLFLN-GNKLARVAAGAFQGLRQLDMLDLSNNSLA 273
+ L L +L+ L LRYL + +L+ + GAFQGL +L +L L +N L
Sbjct: 293 QELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLT 352
Query: 274 SVPEGLWASLGQ--------------PNWDMRD-----------------GFDISG---- 298
++P+GL LG+ P R+ D+ G
Sbjct: 353 ALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPR 412
Query: 299 --------NPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAV 343
N W CD L WL+ + + RCAGP A G L A+
Sbjct: 413 LTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWAL 465
Score = 100 bits (250), Expect = 1e-21
Identities = 71/215 (33%), Positives = 101/215 (46%)
Query: 66 LPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTR 125
LP + H+ + L + G + LQ L +S + + +++P + +L+ L L+R
Sbjct: 48 LPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSR 107
Query: 126 NALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLA 185
N +T LP L L+ L L N L ++ + L L L L+ N+L LP L
Sbjct: 108 NKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFT 167
Query: 186 NFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNG 245
N L+ LDL N L LP LL +LERL L N+L L LL L L +
Sbjct: 168 NLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHR 227
Query: 246 NKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLW 280
N + +A GAF L L L LS N LA +P L+
Sbjct: 228 NHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALF 262
Score = 89.7 bits (221), Expect = 3e-18
Identities = 67/192 (34%), Positives = 88/192 (45%)
Query: 93 KLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQL 152
KL+ L LS N + L L + L L L NAL G+ +FQ L L L +NQL
Sbjct: 99 KLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQL 158
Query: 153 EVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPL 212
+ L S L+ L LDLSGN L LP GLL L L L N+L +L LL
Sbjct: 159 DFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLG 218
Query: 213 QLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSL 272
L L N ++ + P+L L L+ N LA + + F L +L L N L
Sbjct: 219 ALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPL 278
Query: 273 ASVPEGLWASLG 284
A +P L+ +G
Sbjct: 279 AELPGVLFGEMG 290
Score = 65.9 bits (159), Expect = 5e-11
Identities = 85/290 (29%), Positives = 100/290 (34%), Gaps = 77/290 (26%)
Query: 79 NLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPV----------------------- 115
NLTHLP LL +KL+ L L SN L SL L +
Sbjct: 181 NLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDR 240
Query: 116 -PQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVL-----------EVSWLH-- 161
P L L L+RN L LP LF S L L L EN L L + WL+
Sbjct: 241 LPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRT 300
Query: 162 ------------------------------------GLKALGHLDLSGNRLRKLPPGLLA 185
GL L L L N L LP GLL
Sbjct: 301 QLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLR 360
Query: 186 NFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNG 245
LR + L N+L LP L R LE + L+ N+L+ L D+ P L + L
Sbjct: 361 GLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGH 420
Query: 246 NK-LARVAAGAFQG-LRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDG 293
N G F G LRQ L L G A G P W + G
Sbjct: 421 NSWRCDCGLGPFLGWLRQ--HLGLVGGEEPPRCAGPGAHAGLPLWALPGG 468
Score = 65.1 bits (157), Expect = 9e-11
Identities = 49/168 (29%), Positives = 77/168 (45%), Gaps = 5/168 (2%)
Query: 122 DLTRNALTGLPPGLFQASA-----TLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRL 176
+LT L G+ G+ Q+ + L L++ ++ + + L L L LS N++
Sbjct: 51 NLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKI 110
Query: 177 RKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQP 236
LP LL LL L L N L + ++ + + L+ L L N+L L L
Sbjct: 111 THLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLE 170
Query: 237 DLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLG 284
+L+ L L+GN L + G +L+ L L +N L S+ GL SLG
Sbjct: 171 NLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLG 218
Score = 45.4 bits (106), Expect = 7e-05
Identities = 46/169 (27%), Positives = 73/169 (43%), Gaps = 11/169 (6%)
Query: 153 EVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPL 212
+V +S L L H+ L G L + T+L+ L + ++ + + P +
Sbjct: 39 DVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLI 98
Query: 213 QLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSL 272
+L+ L L NK+ L LL L LFL+ N L + FQ L L L L+ N L
Sbjct: 99 KLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQL 158
Query: 273 ASVPEGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKM 321
+P L+ +L + D+SGN NL+ L + L + K+
Sbjct: 159 DFLPASLFTNL-----ENLKLLDLSGN------NLTHLPKGLLGAQAKL 196
>gi|153251229 chondroadherin precursor [Homo sapiens]
Length = 359
Score = 100 bits (249), Expect = 2e-21
Identities = 82/271 (30%), Positives = 116/271 (42%), Gaps = 16/271 (5%)
Query: 71 VHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTG 130
V L ++ + + A +G +L L+LS N + L + +L L L N +T
Sbjct: 78 VSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTE 137
Query: 131 LPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLL 190
LP GL L L L N++ L G K L L LS N L L PG L + L
Sbjct: 138 LPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENL 197
Query: 191 RTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYL---FLNGNK 247
+ NQL + P L +E L L N L+ + + Q RYL +L+
Sbjct: 198 AKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAF--QSFGRYLETLWLDNTN 255
Query: 248 LARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWICDQNL 307
L + + GAF G+ L + L NN L +P +D + ++ NPW C L
Sbjct: 256 LEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF-------PFDSLETLALTNNPWKCTCQL 308
Query: 308 SDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQ 338
L RWL+A+ S+ D CA P KGQ
Sbjct: 309 RGLRRWLEAKA----SRPDATCASPAKFKGQ 335
Score = 42.7 bits (99), Expect = 5e-04
Identities = 38/132 (28%), Positives = 54/132 (40%), Gaps = 32/132 (24%)
Query: 171 LSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKD 230
L+ N R +P L +L L Q+ + RG QL L+L N ++VL
Sbjct: 66 LAANSFRAMPN--------LVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAG 117
Query: 231 LLLPQPDLRYLF------------------------LNGNKLARVAAGAFQGLRQLDMLD 266
+L YL+ LN NK+ + AGAFQG + L L
Sbjct: 118 AFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLY 177
Query: 267 LSNNSLASVPEG 278
LS N+L+S+ G
Sbjct: 178 LSENALSSLQPG 189
>gi|38202222 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 100 bits (248), Expect = 3e-21
Identities = 85/284 (29%), Positives = 126/284 (44%), Gaps = 39/284 (13%)
Query: 61 EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPE--FLRPVPQL 118
E P LP L ++ N+ + + L L+ELHL N + ++S E R L
Sbjct: 97 EFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYL 156
Query: 119 RVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRK 178
R+L L+RN L+ +P GL T++ L L +N++ + L GL +L L L GN L
Sbjct: 157 RLLFLSRNHLSTIPWGL---PRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNN 213
Query: 179 --LPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQP 236
L + N L L L N L P +L P
Sbjct: 214 HGLGDKVFFNLVNLTELSLVRNSLTAAPVNL--------------------------PGT 247
Query: 237 DLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDI 296
+LR L+L N + RV AF LRQL LD+SNN+L+++P+G++ L D +
Sbjct: 248 NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDL-----DNITQLIL 302
Query: 297 SGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTL 340
NPW C + + WLQ+ K+ + C PE V+G +
Sbjct: 303 RNNPWYCGCKMKWVRDWLQSLPVKV-NVRGLMCQAPEKVRGMAI 345
>gi|7019383 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 100 bits (248), Expect = 3e-21
Identities = 85/284 (29%), Positives = 126/284 (44%), Gaps = 39/284 (13%)
Query: 61 EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPE--FLRPVPQL 118
E P LP L ++ N+ + + L L+ELHL N + ++S E R L
Sbjct: 97 EFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYL 156
Query: 119 RVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRK 178
R+L L+RN L+ +P GL T++ L L +N++ + L GL +L L L GN L
Sbjct: 157 RLLFLSRNHLSTIPWGL---PRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNN 213
Query: 179 --LPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQP 236
L + N L L L N L P +L P
Sbjct: 214 HGLGDKVFFNLVNLTELSLVRNSLTAAPVNL--------------------------PGT 247
Query: 237 DLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDI 296
+LR L+L N + RV AF LRQL LD+SNN+L+++P+G++ L D +
Sbjct: 248 NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDL-----DNITQLIL 302
Query: 297 SGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTL 340
NPW C + + WLQ+ K+ + C PE V+G +
Sbjct: 303 RNNPWYCGCKMKWVRDWLQSLPVKV-NVRGLMCQAPEKVRGMAI 345
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 98.2 bits (243), Expect = 1e-20
Identities = 82/268 (30%), Positives = 119/268 (44%), Gaps = 16/268 (5%)
Query: 80 LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQAS 139
++ L +G L +L L N L +L P+ L L L N + L F
Sbjct: 143 ISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQL 202
Query: 140 ATLDTLVLKENQLE--VLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGE 197
L L L N+L+ + + L++L L LS N L+ L P + + L L L
Sbjct: 203 GKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRG 262
Query: 198 NQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQ 257
NQL L P+ G L L LEGN+L L LL P L L L+GN+L+ + F
Sbjct: 263 NQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFG 322
Query: 258 GLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWL--- 314
L +L L L NN+L+++ ++A+ D+ GN W CD L L RW+
Sbjct: 323 HLGRLRELSLRNNALSALSGDIFAAS-----PALYRLDLDGNGWTCDCRLRGLKRWMGDW 377
Query: 315 --QAQKDKMFSQNDTRCAGPEAVKGQTL 340
Q + +F Q C P A++G+ L
Sbjct: 378 HSQGRLLTVFVQ----CRHPPALRGKYL 401
Score = 79.0 bits (193), Expect = 6e-15
Identities = 63/178 (35%), Positives = 81/178 (45%), Gaps = 2/178 (1%)
Query: 71 VHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESL--SPEFLRPVPQLRVLDLTRNAL 128
++L +E + L N KL+ L+LS+N L+ P+ L L L+ N L
Sbjct: 182 LYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNL 241
Query: 129 TGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFT 188
L P +FQ L L L+ NQL L GL+AL L L GNRL +LP LL
Sbjct: 242 QHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLH 301
Query: 189 LLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGN 246
L LDL N+L L P +L L L N L L D+ P L L L+GN
Sbjct: 302 SLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
Score = 73.9 bits (180), Expect = 2e-13
Identities = 42/114 (36%), Positives = 62/114 (54%)
Query: 171 LSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKD 230
L GN + + LR LDL NQ+ +L P +LE L+L N LQ L
Sbjct: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
Query: 231 LLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLG 284
L P LR L+ NGN+++R++ G+F+GL L L L N+L ++P+ ++A LG
Sbjct: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLG 179
Score = 72.8 bits (177), Expect = 4e-13
Identities = 61/177 (34%), Positives = 85/177 (48%), Gaps = 4/177 (2%)
Query: 99 LSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVS 158
L N + +++ + QLR LDL N + L P F+ + L+ L L N L+ L
Sbjct: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
Query: 159 WLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPL-QLERL 217
L L+ L L +GN + +L G L L L N L LP D + PL L L
Sbjct: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALP-DAVFAPLGNLLYL 184
Query: 218 HLEGNKLQVLGKDLLLPQPDLRYLFLNGNKL--ARVAAGAFQGLRQLDMLDLSNNSL 272
HLE N+++ LGK+ LR+L L+ N+L + A F LR L L LS N+L
Sbjct: 185 HLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNL 241
>gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
sapiens]
Length = 522
Score = 97.1 bits (240), Expect = 2e-20
Identities = 82/338 (24%), Positives = 149/338 (44%), Gaps = 25/338 (7%)
Query: 25 LLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPP--AEIPGYLPADTVHLAVEFFNLTH 82
+L LL A + +P C G + C+ E P L + + L++ + +L+
Sbjct: 21 VLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEAPHNL-SGLLGLSLRYNSLSE 79
Query: 83 LPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATL 142
L A G +L L+L N + S+ + + + +++ L L+ N +T LP F+ L
Sbjct: 80 LRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNL 139
Query: 143 DTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLET 202
++ L N+L+ L HGL+ L L + N ++ +P + + L+ LD+G NQL++
Sbjct: 140 RSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKS 199
Query: 203 LPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQL 262
L + G +L LHLE N L + L L L NK+A + + + L
Sbjct: 200 LARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVA-IVVSSLDWVWNL 258
Query: 263 DMLDLSNNSLASVPEGLWASLGQ-------------------PNWDMRDGFDISGNPWIC 303
+ +DLS N + + ++ ++ +W ++GN W C
Sbjct: 259 EKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDC 318
Query: 304 DQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLL 341
+N+ L WL + + + +CA PE +G+ +L
Sbjct: 319 GRNVCALASWLNNFQGRY--DGNLQCASPEYAQGEDVL 354
>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
sapiens]
Length = 674
Score = 97.1 bits (240), Expect = 2e-20
Identities = 82/282 (29%), Positives = 127/282 (45%), Gaps = 35/282 (12%)
Query: 61 EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPE--FLRPVPQL 118
E P LP L ++ N+ + + L L++LHL N + ++S E QL
Sbjct: 120 EFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQL 179
Query: 119 RVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRK 178
++L L+RN L+ +P GL TL+ L L +N++ + + GL +L L L GN
Sbjct: 180 KLLFLSRNHLSSIPSGL---PHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGN---- 232
Query: 179 LPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDL 238
LLAN + + D L L L N L L LP L
Sbjct: 233 ----LLAN--------------QRIADDTFSRLQNLTELSLVRNSLAA--PPLNLPSAHL 272
Query: 239 RYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISG 298
+ L+L N ++ + +R+L+ LDLSNN+L ++P GL+ LG + +
Sbjct: 273 QKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLL-----LRN 327
Query: 299 NPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTL 340
NPW C NL L W++A + + + C GPE V+G +
Sbjct: 328 NPWFCGCNLMWLRDWVKA-RAAVVNVRGLMCQGPEKVRGMAI 368
>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
Length = 473
Score = 95.5 bits (236), Expect = 6e-20
Identities = 74/251 (29%), Positives = 115/251 (45%), Gaps = 9/251 (3%)
Query: 95 QELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKEN-QLE 153
Q + L N + + R L +L L N L + F A L+ L L +N QL
Sbjct: 60 QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
Query: 154 VLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQ 213
++ + HGL L L L L++L PGL L+ L L +N L+ LP D R
Sbjct: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
Query: 214 LERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLA 273
L L L GN++ + + L L L+ N++A V AF+ L +L L L N+L+
Sbjct: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
Query: 274 SVPEGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPE 333
++P A L + ++ NPW+CD L+ WLQ + S ++ C+ P+
Sbjct: 240 ALPTEALAPLRALQY-----LRLNDNPWVCDCRARPLWAWLQKFRG---SSSEVPCSLPQ 291
Query: 334 AVKGQTLLAVA 344
+ G+ L +A
Sbjct: 292 RLAGRDLKRLA 302
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 94.7 bits (234), Expect = 1e-19
Identities = 75/299 (25%), Positives = 129/299 (43%), Gaps = 21/299 (7%)
Query: 62 IPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVL 121
+P ++ L++ ++T L + S+L LHL N + ++ + + + +L+ L
Sbjct: 55 VPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKEL 114
Query: 122 DLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPP 181
L+ N + LP F L L L NQL L +GL+ L L L N LR +P
Sbjct: 115 ILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPV 174
Query: 182 GLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYL 241
L + L LDL N+L +L + G ++L LHLE N+L + L L L
Sbjct: 175 RLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTL 234
Query: 242 FLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDG-------- 293
FL NK++ + G L+ LDL+ N + ++ ++ ++ + D
Sbjct: 235 FLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDS 294
Query: 294 -----------FDISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLL 341
+SGN W C + L WL + + + ++ C P+ +G+ +L
Sbjct: 295 KILNSLRSLTTVGLSGNLWECSARICALASWLGSFQGRW--EHSILCHSPDHTQGEDIL 351
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 93.6 bits (231), Expect = 2e-19
Identities = 82/233 (35%), Positives = 113/233 (48%), Gaps = 12/233 (5%)
Query: 53 SISCQPPAEIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGL--ESLSPE 110
S+S + +P LP L ++ ++ +P L ++L+EL+L N L L
Sbjct: 199 SLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDAT 258
Query: 111 FLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLD 170
+ L LDL+ N LT +P GL TL L L N++ +E + LHG + L +L
Sbjct: 259 TFSKLHSLEYLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLL 315
Query: 171 LSGNRLRK--LPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLG 228
L N+L LP G L L TL L N L+ +PP L P +L L L N + LG
Sbjct: 316 LQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALG 372
Query: 229 KDLLLPQPDLRYLFLNGNKLA--RVAAGAFQGLRQLDMLDLSNNSLASVPEGL 279
L+ P L L L N+LA RV AF+ LR L LDL+ N L +P GL
Sbjct: 373 ARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGL 425
Score = 87.0 bits (214), Expect = 2e-17
Identities = 74/214 (34%), Positives = 103/214 (48%), Gaps = 12/214 (5%)
Query: 72 HLAVEFFNLTHLPANLLQGASKLQELHLSSNGL--ESLSPEFLRPVPQLRVLDLTRNALT 129
HL+++ L LP N L S L+ L+L +N + E L E + QL+ L + N L+
Sbjct: 76 HLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLS 135
Query: 130 GLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRK--LPPGLLANF 187
P L ++ D L NQ+ + AL + L N+L LPP
Sbjct: 136 VAPQFLPRSLRVAD---LAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGS 192
Query: 188 TLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNK 247
+ TL L NQL LPP L P LERLHL+ N + + + L Q LR L+L N+
Sbjct: 193 EAIATLSLSNNQLSYLPPSL---PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQ 249
Query: 248 L--ARVAAGAFQGLRQLDMLDLSNNSLASVPEGL 279
L + + A F L L+ LDLS+N L +VP GL
Sbjct: 250 LTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGL 283
Score = 71.6 bits (174), Expect = 1e-12
Identities = 59/146 (40%), Positives = 73/146 (50%), Gaps = 8/146 (5%)
Query: 83 LPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATL 142
LPA L+ L LHL NGL+ + P R +LR L L N + L A+ L
Sbjct: 326 LPAGALRPLRGLHTLHLYGNGLDRVPPALPR---RLRALVLPHNHVAALGARDLVATPGL 382
Query: 143 DTLVLKENQLEVLEVSW--LHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQL 200
L L N+L V L+AL LDL+GN+L +LP GL T LRTL L NQL
Sbjct: 383 TELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLP---TGLRTLQLQRNQL 439
Query: 201 ETLPPDLLRGPLQLERLHLEGNKLQV 226
L P+ L G QL L L N+L+V
Sbjct: 440 RMLEPEPLAGLDQLRELSLAHNRLRV 465
Score = 62.0 bits (149), Expect = 8e-10
Identities = 67/209 (32%), Positives = 90/209 (43%), Gaps = 12/209 (5%)
Query: 62 IPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLES--LSPEFLRPVPQLR 119
+P LP L + + + A L GA L+ L L N L S L LRP+ L
Sbjct: 279 VPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLH 338
Query: 120 VLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLR-- 177
L L N L +PP L L LVL N + L L L L+L+ NRL
Sbjct: 339 TLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASA 395
Query: 178 KLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPD 237
++ LR+LDL NQL LP L P L L L+ N+L++L + L
Sbjct: 396 RVHHRAFRRLRALRSLDLAGNQLTRLPMGL---PTGLRTLQLQRNQLRMLEPEPLAGLDQ 452
Query: 238 LRYLFLNGNKL--ARVAAGAFQGLRQLDM 264
LR L L N+L + G + L+ L +
Sbjct: 453 LRELSLAHNRLRVGDIGPGTWHELQALQV 481
Score = 55.1 bits (131), Expect = 9e-08
Identities = 47/145 (32%), Positives = 70/145 (48%), Gaps = 25/145 (17%)
Query: 164 KALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQL--ETLPPDLLRGPLQLERLHLEG 221
+A HL L N+L++LP L+ + LRTL+L N + E LP + QL+ L +
Sbjct: 72 RAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAH 131
Query: 222 NKLQVLGKDL----------------LLP-----QPDLRYLFLNGNKL--ARVAAGAFQG 258
NKL V + L + P +P LR ++L+ N+L A + AF+G
Sbjct: 132 NKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRG 191
Query: 259 LRQLDMLDLSNNSLASVPEGLWASL 283
+ L LSNN L+ +P L SL
Sbjct: 192 SEAIATLSLSNNQLSYLPPSLPPSL 216
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 93.6 bits (231), Expect = 2e-19
Identities = 82/233 (35%), Positives = 113/233 (48%), Gaps = 12/233 (5%)
Query: 53 SISCQPPAEIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGL--ESLSPE 110
S+S + +P LP L ++ ++ +P L ++L+EL+L N L L
Sbjct: 201 SLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDAT 260
Query: 111 FLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLD 170
+ L LDL+ N LT +P GL TL L L N++ +E + LHG + L +L
Sbjct: 261 TFSKLHSLEYLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLL 317
Query: 171 LSGNRLRK--LPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLG 228
L N+L LP G L L TL L N L+ +PP L P +L L L N + LG
Sbjct: 318 LQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALG 374
Query: 229 KDLLLPQPDLRYLFLNGNKLA--RVAAGAFQGLRQLDMLDLSNNSLASVPEGL 279
L+ P L L L N+LA RV AF+ LR L LDL+ N L +P GL
Sbjct: 375 ARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGL 427
Score = 87.0 bits (214), Expect = 2e-17
Identities = 74/214 (34%), Positives = 103/214 (48%), Gaps = 12/214 (5%)
Query: 72 HLAVEFFNLTHLPANLLQGASKLQELHLSSNGL--ESLSPEFLRPVPQLRVLDLTRNALT 129
HL+++ L LP N L S L+ L+L +N + E L E + QL+ L + N L+
Sbjct: 78 HLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLS 137
Query: 130 GLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRK--LPPGLLANF 187
P L ++ D L NQ+ + AL + L N+L LPP
Sbjct: 138 VAPQFLPRSLRVAD---LAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGS 194
Query: 188 TLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNK 247
+ TL L NQL LPP L P LERLHL+ N + + + L Q LR L+L N+
Sbjct: 195 EAIATLSLSNNQLSYLPPSL---PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQ 251
Query: 248 L--ARVAAGAFQGLRQLDMLDLSNNSLASVPEGL 279
L + + A F L L+ LDLS+N L +VP GL
Sbjct: 252 LTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGL 285
Score = 71.6 bits (174), Expect = 1e-12
Identities = 59/146 (40%), Positives = 73/146 (50%), Gaps = 8/146 (5%)
Query: 83 LPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATL 142
LPA L+ L LHL NGL+ + P R +LR L L N + L A+ L
Sbjct: 328 LPAGALRPLRGLHTLHLYGNGLDRVPPALPR---RLRALVLPHNHVAALGARDLVATPGL 384
Query: 143 DTLVLKENQLEVLEVSW--LHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQL 200
L L N+L V L+AL LDL+GN+L +LP GL T LRTL L NQL
Sbjct: 385 TELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLP---TGLRTLQLQRNQL 441
Query: 201 ETLPPDLLRGPLQLERLHLEGNKLQV 226
L P+ L G QL L L N+L+V
Sbjct: 442 RMLEPEPLAGLDQLRELSLAHNRLRV 467
Score = 62.0 bits (149), Expect = 8e-10
Identities = 67/209 (32%), Positives = 90/209 (43%), Gaps = 12/209 (5%)
Query: 62 IPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLES--LSPEFLRPVPQLR 119
+P LP L + + + A L GA L+ L L N L S L LRP+ L
Sbjct: 281 VPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLH 340
Query: 120 VLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLR-- 177
L L N L +PP L L LVL N + L L L L+L+ NRL
Sbjct: 341 TLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASA 397
Query: 178 KLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPD 237
++ LR+LDL NQL LP L P L L L+ N+L++L + L
Sbjct: 398 RVHHRAFRRLRALRSLDLAGNQLTRLPMGL---PTGLRTLQLQRNQLRMLEPEPLAGLDQ 454
Query: 238 LRYLFLNGNKL--ARVAAGAFQGLRQLDM 264
LR L L N+L + G + L+ L +
Sbjct: 455 LRELSLAHNRLRVGDIGPGTWHELQALQV 483
Score = 55.1 bits (131), Expect = 9e-08
Identities = 47/145 (32%), Positives = 70/145 (48%), Gaps = 25/145 (17%)
Query: 164 KALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQL--ETLPPDLLRGPLQLERLHLEG 221
+A HL L N+L++LP L+ + LRTL+L N + E LP + QL+ L +
Sbjct: 74 RAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAH 133
Query: 222 NKLQVLGKDL----------------LLP-----QPDLRYLFLNGNKL--ARVAAGAFQG 258
NKL V + L + P +P LR ++L+ N+L A + AF+G
Sbjct: 134 NKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRG 193
Query: 259 LRQLDMLDLSNNSLASVPEGLWASL 283
+ L LSNN L+ +P L SL
Sbjct: 194 SEAIATLSLSNNQLSYLPPSLPPSL 218
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 92.8 bits (229), Expect = 4e-19
Identities = 75/254 (29%), Positives = 110/254 (43%), Gaps = 5/254 (1%)
Query: 35 GVTLSPKDCQVFRSDHGSSISCQPP--AEIPGYLPADTVHLAVEFFNLTHLPANLLQGAS 92
G T P C S C + +PG L T +L + NLT L L
Sbjct: 31 GPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLR 90
Query: 93 KLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQL 152
L+EL LS N L + + + L++L L N L G+P +L +L L N +
Sbjct: 91 FLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLI 150
Query: 153 EVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPL 212
++ GL +L HL L N L ++P L N L+ + L N++ +P +
Sbjct: 151 SLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLT 210
Query: 213 QLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSL 272
L LHL N++Q LG +L L LN NKL A + L +L L NN++
Sbjct: 211 SLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNI 269
Query: 273 ASVPEGLWASLGQP 286
++PE A +G P
Sbjct: 270 KAIPEK--AFMGNP 281
Score = 73.2 bits (178), Expect = 3e-13
Identities = 63/243 (25%), Positives = 104/243 (42%), Gaps = 29/243 (11%)
Query: 60 AEIPGYLPADTVHLAVEFFN---LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVP 116
+ IP Y + L V + + HL + +G L+ L L+ N L+ P +R +
Sbjct: 199 SHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLG 257
Query: 117 QLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLE----------------------- 153
+L+ L N + +P F + L T+ +N ++
Sbjct: 258 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMD 317
Query: 154 VLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQ 213
+ E L G +L L L+ +R LP G+ LR L+L NQ+E LP L +
Sbjct: 318 IQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQK 375
Query: 214 LERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLA 273
LE + L+ N++ +G D L+ L L+ N + + AF L L LDL++N L
Sbjct: 376 LEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLT 435
Query: 274 SVP 276
++P
Sbjct: 436 TLP 438
Score = 62.4 bits (150), Expect = 6e-10
Identities = 52/156 (33%), Positives = 75/156 (48%), Gaps = 10/156 (6%)
Query: 88 LQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVL 147
L+G + L+ L L+ G+ L + +P+LRVL+L+ N + LP L+ + L
Sbjct: 324 LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGL 381
Query: 148 KENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDL 207
+ N++ + L +L LDLS N +R + P + L LDL +NQL TLP
Sbjct: 382 QHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP--- 438
Query: 208 LRGPLQLERLHLEGNKL--QVLGKDLLLPQPDLRYL 241
L G L L L+GN Q KD P LR L
Sbjct: 439 LAGLGGLMHLKLKGNLALSQAFSKDSF---PKLRIL 471
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 92.0 bits (227), Expect = 7e-19
Identities = 76/258 (29%), Positives = 114/258 (44%), Gaps = 4/258 (1%)
Query: 24 FLLLLLAASAWGVTLSPKDCQVFRSDHGSS-ISCQPPA--EIPGYLPADTVHLAVEFFNL 80
FL L L SA +P C S G + C +P L A T L + N+
Sbjct: 10 FLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNI 69
Query: 81 THLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASA 140
T LP + + L+EL L+ N L + P+ L + +L+VL L N L +P + +
Sbjct: 70 TQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLS 129
Query: 141 TLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQL 200
L +L L N + + GL L HL L N L ++P L+N L+ L L N++
Sbjct: 130 ALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKI 189
Query: 201 ETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLR 260
++P L LHL NK++ L + +L L LN N L A + L
Sbjct: 190 SSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ-AIKALP 248
Query: 261 QLDMLDLSNNSLASVPEG 278
L L +NS++ +P+G
Sbjct: 249 SLKELGFHSNSISVIPDG 266
Score = 72.8 bits (177), Expect = 4e-13
Identities = 50/165 (30%), Positives = 78/165 (47%), Gaps = 3/165 (1%)
Query: 119 RVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRK 178
R +D + LT +P GL SA L + N + L L L L+GN L
Sbjct: 39 RRVDCSGKGLTAVPEGL---SAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSF 95
Query: 179 LPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDL 238
+ P L+ L+ L L NQL+T+P + +RG L+ L L+ N + + +D L
Sbjct: 96 IHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQL 155
Query: 239 RYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASL 283
R+L+L+ N L V L L L L+ N ++S+P+ + +L
Sbjct: 156 RHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNL 200
Score = 72.0 bits (175), Expect = 7e-13
Identities = 62/221 (28%), Positives = 97/221 (43%), Gaps = 27/221 (12%)
Query: 83 LPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATL 142
L + G L+ L L+ N L P+ ++ +P L+ L N+++ +P G F + L
Sbjct: 216 LSQHCFDGLDNLETLDLNYNNLGEF-PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLL 274
Query: 143 DTLVLKENQLEVLEVSWLHGLKALG--------------------HLD---LSGNRLRKL 179
T+ L +N L + S H L L HL+ L+G ++ +
Sbjct: 275 RTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSI 334
Query: 180 PPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLR 239
P L +LRTLDL N + LP G LE + L+ N++ + + LR
Sbjct: 335 PNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLR 392
Query: 240 YLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVP-EGL 279
L L+ N + + + AF L + LD+S N L S P EGL
Sbjct: 393 ILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGL 433
Score = 60.8 bits (146), Expect = 2e-09
Identities = 54/194 (27%), Positives = 85/194 (43%), Gaps = 26/194 (13%)
Query: 50 HGSSISCQPPAEIPGYLPADTVHLAVE---------FFNLTHLPANLLQGASKLQE---- 96
H +SIS P G T+HL F NL+ L + +++GAS +Q+
Sbjct: 256 HSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNL 315
Query: 97 --------LHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLK 148
L L+ + S+ + LR LDL+ N + LP F L+ + L+
Sbjct: 316 TGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQ 373
Query: 149 ENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLL 208
NQ+ ++ GL +L LDLS N + ++ A + LD+ N+L + P + L
Sbjct: 374 RNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGL 433
Query: 209 RGPLQLERLHLEGN 222
G L +L L GN
Sbjct: 434 NG---LNQLKLVGN 444
Score = 59.7 bits (143), Expect = 4e-09
Identities = 43/117 (36%), Positives = 57/117 (48%), Gaps = 3/117 (2%)
Query: 169 LDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLG 228
+D SG L +P GL A FT + LD+ N + LP D + LE L L GN L +
Sbjct: 41 VDCSGKGLTAVPEGLSA-FT--QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIH 97
Query: 229 KDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQ 285
L +L+ L L N+L V + A +GL L L L N + SVPE + L Q
Sbjct: 98 PKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQ 154
>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
sapiens]
Length = 660
Score = 91.7 bits (226), Expect = 9e-19
Identities = 75/284 (26%), Positives = 122/284 (42%), Gaps = 39/284 (13%)
Query: 61 EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPE--FLRPVPQL 118
E P LP + L ++ N+ + L KL+ELHL N + ++ E R L
Sbjct: 102 EFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISL 161
Query: 119 RVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRL-- 176
++L L++N L+ +P GL L L + EN++ V+ L +L L + GN L
Sbjct: 162 KLLFLSKNHLSSVPVGL---PVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTN 218
Query: 177 RKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQP 236
+ + G ++ T L+ + N L PPDL P
Sbjct: 219 KGIAEGTFSHLTKLKEFSIVRNSLSHPPPDL--------------------------PGT 252
Query: 237 DLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDI 296
L L+L N++ + AF LR+L+ LD+SNN L + +G++ +L
Sbjct: 253 HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSN-----LKQLTA 307
Query: 297 SGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTL 340
NPW CD ++ + WL+ + + C GPE V+G +
Sbjct: 308 RNNPWFCDCSIKWVTEWLKYIPSSL-NVRGFMCQGPEQVRGMAV 350
Score = 53.9 bits (128), Expect = 2e-07
Identities = 56/187 (29%), Positives = 84/187 (44%), Gaps = 32/187 (17%)
Query: 127 ALTGLPPGLFQASATLDTLVLKENQLEVLEV-SWLHGLKALGHLDLSGNRLRKLPPGLLA 185
+LT +P G+ + + L L NQ+ + LH ++++ + L GN+L + P L
Sbjct: 53 SLTSVPLGIPEG---VTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPK 109
Query: 186 NFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNG 245
N +R L L EN ++T+ L L+LE LHL+ N + +G
Sbjct: 110 N---VRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVG----------------- 149
Query: 246 NKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWICDQ 305
V GAF+ L +L LS N L+SVP GL L + D IS + Q
Sbjct: 150 -----VEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISD---MAFQ 201
Query: 306 NLSDLYR 312
NL+ L R
Sbjct: 202 NLTSLER 208
>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
Length = 441
Score = 91.3 bits (225), Expect = 1e-18
Identities = 94/319 (29%), Positives = 131/319 (41%), Gaps = 39/319 (12%)
Query: 25 LLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPP--AEIPGYLPADTVHLAVEFFNLTH 82
LLLL+AA P+DC + + ++SCQ A IP +P D+
Sbjct: 11 LLLLVAAELPLGGGCPRDCVCYPAP--MTVSCQAHNFAAIPEGIPVDS------------ 56
Query: 83 LPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATL 142
+ + L +N + L P P + L + N +T + P F+ L
Sbjct: 57 ------------ERVFLQNNRIGLLQPGHFSPA--MVTLWIYSNNITYIHPSTFEGFVHL 102
Query: 143 DTLVLKEN-QLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLE 201
+ L L +N QL L GL L L L L LP G+ L+ L L +N +E
Sbjct: 103 EELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIE 162
Query: 202 TLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQ 261
L D+ + L L L GNKL LG +L L L+ N+L V AF LR+
Sbjct: 163 YLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRR 222
Query: 262 LDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKM 321
L L L NNSL+ + A LG + ++GNPW C L+ WLQ +
Sbjct: 223 LTTLFLFNNSLSELQGECLAPLGALEF-----LRLNGNPWDCGCRARSLWEWLQRFRG-- 275
Query: 322 FSQNDTRCAGPEAVKGQTL 340
S + C P GQ L
Sbjct: 276 -SSSAVPCVSPGLRHGQDL 293
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 90.9 bits (224), Expect = 2e-18
Identities = 70/259 (27%), Positives = 116/259 (44%), Gaps = 13/259 (5%)
Query: 89 QGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLK 148
QG L+ L + NG+ L + + L+L N LT + G L L +
Sbjct: 236 QGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVS 295
Query: 149 ENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLL 208
+N +E + + L LDLS N+L +L +LL L+LG+N++ + +
Sbjct: 296 QNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVF 355
Query: 209 RGPLQLERLHLEGNKLQVLGKD---LLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDML 265
R L+ L L N++ +D L L L GN++ + AF GL L+ L
Sbjct: 356 RFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHL 415
Query: 266 DLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKMFSQN 325
DL+NN++ S+ E ++ ++ + +CD +L L +WL D F +
Sbjct: 416 DLNNNAIMSIQENAFSQTHLKE------LILNTSSLLCDCHLKWLLQWL---VDNNFQHS 466
Query: 326 -DTRCAGPEAVKGQTLLAV 343
+ CA PE + GQ++L V
Sbjct: 467 VNVSCAHPEWLAGQSILNV 485
Score = 70.9 bits (172), Expect = 2e-12
Identities = 67/255 (26%), Positives = 114/255 (44%), Gaps = 11/255 (4%)
Query: 32 SAWGVTLSPKDCQVFRSDHGSSISCQPPAEIPGY-LPADTVHLAVEFFNLT-HLPANLLQ 89
S W ++L + Q + ++ EIP + P + L N+ + A LQ
Sbjct: 88 SNWNISLESQTLQEVKMNYNEL------TEIPYFGEPTSNITLLSLVHNIIPEINAQALQ 141
Query: 90 GASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLF-QASATLDTLVLK 148
L+ L LSSN + + P QL+ L+L+ N +T L G F S++L + L
Sbjct: 142 FYPALESLDLSSNIISEIKTSSF-PRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLN 200
Query: 149 ENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLL 208
N++ ++ + L L L+L NR++ + LR+L + N + L
Sbjct: 201 RNRMSMIPPK-IFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAF 259
Query: 209 RGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLS 268
G +E L LE N L + K L L+ L+++ N + R++ A++ ++L LDLS
Sbjct: 260 FGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLS 319
Query: 269 NNSLASVPEGLWASL 283
N L + E + L
Sbjct: 320 YNQLTRLDESAFVGL 334
>gi|88702793 slit-like 2 [Homo sapiens]
Length = 673
Score = 90.9 bits (224), Expect = 2e-18
Identities = 82/256 (32%), Positives = 114/256 (44%), Gaps = 33/256 (12%)
Query: 23 LFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISC--QPPAEIPGYLPADTVHLAVEFFNL 80
L LLLL A GV P CQ + ++ C + +P +P DTV L
Sbjct: 8 LLPLLLLLALGPGVQGCPSGCQCSQPQ---TVFCTARQGTTVPRDVPPDTVGL------- 57
Query: 81 THLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASA 140
++ NG+ L +P L++LDL++N + LP G+FQ A
Sbjct: 58 -----------------YVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLA 100
Query: 141 TLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQL 200
L L L N+L + GL+ L L L NR+R + PG L L L +N+L
Sbjct: 101 NLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNEL 160
Query: 201 ETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLR 260
LPP LR P +L L L N L L + +L ++ L L G L ++ G F LR
Sbjct: 161 RALPP--LRLP-RLLLLDLSHNSLLAL-EPGILDTANVEALRLAGLGLQQLDEGLFSRLR 216
Query: 261 QLDMLDLSNNSLASVP 276
L LD+S+N L VP
Sbjct: 217 NLHDLDVSDNQLERVP 232
Score = 66.2 bits (160), Expect = 4e-11
Identities = 53/162 (32%), Positives = 79/162 (48%), Gaps = 4/162 (2%)
Query: 80 LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQAS 139
+ H+ +L EL L N L +L P LR +P+L +LDL+ N+L L PG+ +
Sbjct: 136 IRHIQPGAFDTLDRLLELKLQDNELRALPP--LR-LPRLLLLDLSHNSLLALEPGILD-T 191
Query: 140 ATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQ 199
A ++ L L L+ L+ L+ L LD+S N+L ++PP + L R G +
Sbjct: 192 ANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRGLTRLRLAGNTR 251
Query: 200 LETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYL 241
+ L P+ L G L+ L + LQ L DL P LR L
Sbjct: 252 IAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLL 293
Score = 40.4 bits (93), Expect = 0.002
Identities = 20/48 (41%), Positives = 30/48 (62%)
Query: 236 PDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASL 283
PD L++ N + + AG+F GL L +LDLS N +AS+P G++ L
Sbjct: 52 PDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPL 99
Score = 38.5 bits (88), Expect = 0.009
Identities = 25/87 (28%), Positives = 40/87 (45%)
Query: 197 ENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAF 256
EN + L G L+ L L N++ L + P +L L L N+L + F
Sbjct: 61 ENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETF 120
Query: 257 QGLRQLDMLDLSNNSLASVPEGLWASL 283
+GLR+L+ L L N + + G + +L
Sbjct: 121 RGLRRLERLYLGKNRIRHIQPGAFDTL 147
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,603,346
Number of Sequences: 37866
Number of extensions: 687293
Number of successful extensions: 4545
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 1536
Number of HSP's gapped (non-prelim): 1277
length of query: 347
length of database: 18,247,518
effective HSP length: 103
effective length of query: 244
effective length of database: 14,347,320
effective search space: 3500746080
effective search space used: 3500746080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.