Search of human proteins with 16418445

Search of human proteins with 16418445

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16418445 leucine rich repeat containing 3B [Homo sapiens]
         (259 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16418445 leucine rich repeat containing 3B [Homo sapiens]          529   e-151
gi|13562088 leucine-rich repeat-containing 3 precursor [Homo sap...   233   1e-61
gi|239756808 PREDICTED: similar to hCG2044133 [Homo sapiens]          163   1e-40
gi|239751294 PREDICTED: similar to hCG2044133 [Homo sapiens]          163   1e-40
gi|239745789 PREDICTED: hypothetical protein LOC728129 [Homo sap...   163   1e-40
gi|72534676 leucine rich repeat containing 17 isoform 1 [Homo sa...    83   2e-16
gi|11321571 slit homolog 3 [Homo sapiens]                              80   2e-15
gi|4759146 slit homolog 2 [Homo sapiens]                               75   4e-14
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho...    75   7e-14
gi|51317373 netrin-G1 ligand [Homo sapiens]                            74   1e-13
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]          73   2e-13
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]            70   2e-12
gi|109150416 peroxidasin [Homo sapiens]                                70   2e-12
gi|88702793 slit-like 2 [Homo sapiens]                                 68   9e-12
gi|188528675 slit homolog 1 [Homo sapiens]                             67   1e-11
gi|194018474 leucine rich repeat containing 52 [Homo sapiens]          67   2e-11
gi|13194201 reticulon 4 receptor precursor [Homo sapiens]              66   3e-11
gi|4826816 leucine-rich, glioma inactivated 1 precursor [Homo sa...    65   5e-11
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ...    64   1e-10
gi|4502403 biglycan preproprotein [Homo sapiens]                       63   3e-10
gi|225579152 insulin-like growth factor binding protein, acid la...    62   6e-10
gi|4826772 insulin-like growth factor binding protein, acid labi...    62   6e-10
gi|19743846 decorin isoform a preproprotein [Homo sapiens]             61   8e-10
gi|4503271 decorin isoform a preproprotein [Homo sapiens]              61   8e-10
gi|31542244 leucine rich repeat and fibronectin type III domain ...    61   8e-10
gi|12007646 nyctalopin precursor [Homo sapiens]                        61   1e-09
gi|126517478 peroxidasin homolog-like [Homo sapiens]                   60   2e-09
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor...    60   2e-09
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor...    60   2e-09
gi|5901992 keratocan [Homo sapiens]                                    60   2e-09

>gi|16418445 leucine rich repeat containing 3B [Homo sapiens]
          Length = 259

 Score =  529 bits (1363), Expect = e-151
 Identities = 259/259 (100%), Positives = 259/259 (100%)

Query: 1   MNLVDLWLTRSLSMCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPR 60
           MNLVDLWLTRSLSMCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPR
Sbjct: 1   MNLVDLWLTRSLSMCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPR 60

Query: 61  DLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDL 120
           DLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDL
Sbjct: 61  DLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDL 120

Query: 121 SDNRIQSVHKNAFNNLKARARIANNPWHCDCTLQQVLRSMASNHETAHNVICKTSVLDEH 180
           SDNRIQSVHKNAFNNLKARARIANNPWHCDCTLQQVLRSMASNHETAHNVICKTSVLDEH
Sbjct: 121 SDNRIQSVHKNAFNNLKARARIANNPWHCDCTLQQVLRSMASNHETAHNVICKTSVLDEH 180

Query: 181 AGRPFLNAANDADLCNLPKKTTDYAMLVTMFGWFTMVISYVVYYVRQNQEDARRHLEYLK 240
           AGRPFLNAANDADLCNLPKKTTDYAMLVTMFGWFTMVISYVVYYVRQNQEDARRHLEYLK
Sbjct: 181 AGRPFLNAANDADLCNLPKKTTDYAMLVTMFGWFTMVISYVVYYVRQNQEDARRHLEYLK 240

Query: 241 SLPSRQKKADEPDDISTVV 259
           SLPSRQKKADEPDDISTVV
Sbjct: 241 SLPSRQKKADEPDDISTVV 259


>gi|13562088 leucine-rich repeat-containing 3 precursor [Homo
           sapiens]
          Length = 257

 Score =  233 bits (595), Expect = 1e-61
 Identities = 117/242 (48%), Positives = 160/242 (66%), Gaps = 2/242 (0%)

Query: 11  SLSMCLLLQSFVLMILCFHSASMCPKGCLCSS-SGGLNVTCSNANLKEIPRDLPPETVLL 69
           SL +    +S + ++ C H  + CP+ C C   +G + V CS   L+E+P D+P  TVLL
Sbjct: 10  SLLLVSTRESCLFLLFCLHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLL 69

Query: 70  YLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVH 129
            LD+N+I+ +P+  F+ LH+LR L+LS N IE I    F G+A  L+ LDLS NRIQ + 
Sbjct: 70  KLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIP 129

Query: 130 KNAFNNLKARARIANNPWHCDCTLQQVLRSMASNHETAHNVICKTSVLDEHAGRPFLNAA 189
           K+A   L A+ R+++NP HC+C LQ+ L  +  + ++   + C TSV +E  G+P + A 
Sbjct: 130 KDALGKLSAKIRLSHNPLHCECALQEALWELKLDPDSVDEIACHTSVQEEFVGKPLVQAL 189

Query: 190 N-DADLCNLPKKTTDYAMLVTMFGWFTMVISYVVYYVRQNQEDARRHLEYLKSLPSRQKK 248
           +  A LC++P +TTD AMLVTMFGWF MVI+YVVYYVR NQEDARRHLEYLKSLPS    
Sbjct: 190 DAGASLCSVPHRTTDVAMLVTMFGWFAMVIAYVVYYVRHNQEDARRHLEYLKSLPSAPAS 249

Query: 249 AD 250
            D
Sbjct: 250 KD 251


>gi|239756808 PREDICTED: similar to hCG2044133 [Homo sapiens]
          Length = 275

 Score =  163 bits (413), Expect = 1e-40
 Identities = 88/235 (37%), Positives = 138/235 (58%), Gaps = 8/235 (3%)

Query: 30  SASMCPKGC-LCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLH 88
           S  + P+GC +   +G     CS A L  +P  +P +T  LYLD+NQ+ S+P   F+ L 
Sbjct: 44  SPQVPPRGCYVAKEAGERTFRCSQAGLSAVPSGIPNDTRKLYLDANQLASVPAGAFQHLP 103

Query: 89  QLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARARIANNPWH 148
            L  L+LS N +  +   AF+G+  TL+ LDLS N++ SV   AF  L+ +  ++ NPWH
Sbjct: 104 VLEELDLSHNALAHLSGAAFQGLEGTLRHLDLSANQLASVPVEAFVGLQIQVNLSANPWH 163

Query: 149 CDCTLQQVLRSMASNHETAHNVICKTSVLDEHAGRPFLNAANDADLCNL----PKKTTDY 204
           CDC LQ+VLR +     T   ++C +    +  G+ FL  A + +LC       +++TD 
Sbjct: 164 CDCALQEVLRQVRLVPGTGTGIVCGSGARPDLVGQEFLLLAGEEELCGSGWGGARRSTDV 223

Query: 205 AMLVTMFGWFTMVISYVVYYVRQNQEDARRHLEYLKSLPSRQKKADEPDDISTVV 259
           A+LVTM GW T++++Y+V+YV QN+++ RR L+    LP R   +++   +STVV
Sbjct: 224 ALLVTMGGWLTLMVAYLVHYVWQNRDETRRSLKRAPVLPVR---SEDSSILSTVV 275


>gi|239751294 PREDICTED: similar to hCG2044133 [Homo sapiens]
          Length = 275

 Score =  163 bits (413), Expect = 1e-40
 Identities = 88/235 (37%), Positives = 138/235 (58%), Gaps = 8/235 (3%)

Query: 30  SASMCPKGC-LCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLH 88
           S  + P+GC +   +G     CS A L  +P  +P +T  LYLD+NQ+ S+P   F+ L 
Sbjct: 44  SPQVPPRGCYVAKEAGERTFRCSQAGLSAVPSGIPNDTRKLYLDANQLASVPAGAFQHLP 103

Query: 89  QLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARARIANNPWH 148
            L  L+LS N +  +   AF+G+  TL+ LDLS N++ SV   AF  L+ +  ++ NPWH
Sbjct: 104 VLEELDLSHNALAHLSGAAFQGLEGTLRHLDLSANQLASVPVEAFVGLQIQVNLSANPWH 163

Query: 149 CDCTLQQVLRSMASNHETAHNVICKTSVLDEHAGRPFLNAANDADLCNL----PKKTTDY 204
           CDC LQ+VLR +     T   ++C +    +  G+ FL  A + +LC       +++TD 
Sbjct: 164 CDCALQEVLRQVRLVPGTGTGIVCGSGARPDLVGQEFLLLAGEEELCGSGWGGARRSTDV 223

Query: 205 AMLVTMFGWFTMVISYVVYYVRQNQEDARRHLEYLKSLPSRQKKADEPDDISTVV 259
           A+LVTM GW T++++Y+V+YV QN+++ RR L+    LP R   +++   +STVV
Sbjct: 224 ALLVTMGGWLTLMVAYLVHYVWQNRDETRRSLKRAPVLPVR---SEDSSILSTVV 275


>gi|239745789 PREDICTED: hypothetical protein LOC728129 [Homo
           sapiens]
          Length = 275

 Score =  163 bits (413), Expect = 1e-40
 Identities = 88/235 (37%), Positives = 138/235 (58%), Gaps = 8/235 (3%)

Query: 30  SASMCPKGC-LCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLH 88
           S  + P+GC +   +G     CS A L  +P  +P +T  LYLD+NQ+ S+P   F+ L 
Sbjct: 44  SPQVPPRGCYVAKEAGERTFRCSQAGLSAVPSGIPNDTRKLYLDANQLASVPAGAFQHLP 103

Query: 89  QLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARARIANNPWH 148
            L  L+LS N +  +   AF+G+  TL+ LDLS N++ SV   AF  L+ +  ++ NPWH
Sbjct: 104 VLEELDLSHNALAHLSGAAFQGLEGTLRHLDLSANQLASVPVEAFVGLQIQVNLSANPWH 163

Query: 149 CDCTLQQVLRSMASNHETAHNVICKTSVLDEHAGRPFLNAANDADLCNL----PKKTTDY 204
           CDC LQ+VLR +     T   ++C +    +  G+ FL  A + +LC       +++TD 
Sbjct: 164 CDCALQEVLRQVRLVPGTGTGIVCGSGARPDLVGQEFLLLAGEEELCGSGWGGARRSTDV 223

Query: 205 AMLVTMFGWFTMVISYVVYYVRQNQEDARRHLEYLKSLPSRQKKADEPDDISTVV 259
           A+LVTM GW T++++Y+V+YV QN+++ RR L+    LP R   +++   +STVV
Sbjct: 224 ALLVTMGGWLTLMVAYLVHYVWQNRDETRRSLKRAPVLPVR---SEDSSILSTVV 275


>gi|72534676 leucine rich repeat containing 17 isoform 1 [Homo
           sapiens]
          Length = 441

 Score = 83.2 bits (204), Expect = 2e-16
 Identities = 46/128 (35%), Positives = 72/128 (56%), Gaps = 4/128 (3%)

Query: 50  CSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFK 109
           C    LK++P ++PP+ V L L  N+I  +  + F+D+H+L+ LNLS NGIEFID  AF 
Sbjct: 254 CKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFL 313

Query: 110 GVAETLQTLDLSDNRIQSVHKNAFNNL--KARARIANNPWHCDCTLQQVLRSMASNHETA 167
           G+   L+ LDLS+N +Q+       +L       + +NPW CD  +  +   +  ++   
Sbjct: 314 GLTH-LEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKHHYNVH 372

Query: 168 HNVI-CKT 174
            N + CKT
Sbjct: 373 FNGLECKT 380



 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 32/110 (29%), Positives = 58/110 (52%), Gaps = 3/110 (2%)

Query: 50  CSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFK 109
           C    L  +    P + + + L  N+I ++ N +F    +L+ L+L +N I  I+  AF 
Sbjct: 67  CQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFF 126

Query: 110 GVAETLQTLDLSDNRIQSVHKNAF--NNLKARARIANNPWHCDCTLQQVL 157
           G+ + L TL L  N+I+ + +  F    L +  R+ +NPWHC C ++ ++
Sbjct: 127 GLNK-LTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLI 175


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 48/146 (32%), Positives = 73/146 (50%), Gaps = 29/146 (19%)

Query: 34  CPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEI---------- 83
           CP+ C C  +    V CSN  L+ +PR +P +   LYL+ N +T++P E+          
Sbjct: 725 CPEQCTCMETV---VRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLID 781

Query: 84  -------------FKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHK 130
                        F ++  L  L LS N +  I  HAF G+  +L+ L L  N I SV +
Sbjct: 782 LSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGL-RSLRVLTLHGNDISSVPE 840

Query: 131 NAFNNLKARARIA--NNPWHCDCTLQ 154
            +FN+L + + +A   NP HCDC+L+
Sbjct: 841 GSFNDLTSLSHLALGTNPLHCDCSLR 866



 Score = 65.9 bits (159), Expect = 3e-11
 Identities = 41/105 (39%), Positives = 58/105 (55%), Gaps = 5/105 (4%)

Query: 33  MCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIP-NEIFKDLHQLR 91
           +CP+ C C    G  V CSN  L  IP  LP     L L+ N+++ +    IFK L  LR
Sbjct: 504 VCPEKCRCE---GTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLR 560

Query: 92  VLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNL 136
            +NLS N I+ + E AF G A ++Q L L+ N++++VH   F  L
Sbjct: 561 KINLSNNKIKEVREGAFDGAA-SVQELMLTGNQLETVHGRVFRGL 604



 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 48/172 (27%), Positives = 72/172 (41%), Gaps = 30/172 (17%)

Query: 12  LSMCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYL 71
           L++ L L S    +L    A  CP  C CS++   +V C    L+ +PR +P     L L
Sbjct: 16  LALALALAS----VLSGPPAVACPTKCTCSAA---SVDCHGLGLRAVPRGIPRNAERLDL 68

Query: 72  DSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAE------------------ 113
           D N IT I    F  L  LRVL+L  N +  I+  AF+ + +                  
Sbjct: 69  DRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELL 128

Query: 114 -----TLQTLDLSDNRIQSVHKNAFNNLKARARIANNPWHCDCTLQQVLRSM 160
                 L  LDLS+N+IQ + + AF  +     +  +  H  C      R++
Sbjct: 129 FQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL 180



 Score = 62.4 bits (150), Expect = 4e-10
 Identities = 40/125 (32%), Positives = 64/125 (51%), Gaps = 4/125 (3%)

Query: 27  CFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKD 86
           C  ++  CP  C CS++    V C    L EIP +LP   V + L+ N I +IP   F  
Sbjct: 273 CNANSISCPSPCTCSNN---IVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQ 329

Query: 87  LHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARARIANNP 146
             +L+ +++SKN I  I   AF+G+ ++L +L L  N+I  + K  F+ L +   +  N 
Sbjct: 330 YKKLKRIDISKNQISDIAPDAFQGL-KSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNA 388

Query: 147 WHCDC 151
              +C
Sbjct: 389 NKINC 393



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 35/124 (28%), Positives = 60/124 (48%), Gaps = 3/124 (2%)

Query: 55  LKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAET 114
           L E+     P+   L L  NQI  IP + F+ +  ++ L L  N I  I++ AF+ + + 
Sbjct: 124 LPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRD- 182

Query: 115 LQTLDLSDNRIQSVHKNAFNNL-KARA-RIANNPWHCDCTLQQVLRSMASNHETAHNVIC 172
           L+ L L++N I  +   +FN++ K R  R+ +N  +CDC L  +   +          +C
Sbjct: 183 LEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLC 242

Query: 173 KTSV 176
              V
Sbjct: 243 MAPV 246



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 41/161 (25%), Positives = 72/161 (44%), Gaps = 12/161 (7%)

Query: 48  VTCSNANLKEIPR---DLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFID 104
           +  SN  +KE+     D       L L  NQ+ ++   +F+ L  L+ L L  N I  + 
Sbjct: 562 INLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVS 621

Query: 105 EHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARARI--ANNPWHCDCTLQQVLRSMAS 162
              F G++ +++ L L DNRI ++   AF  L + + I   +NP++C+C L  + + +  
Sbjct: 622 NDTFAGLS-SVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRK 680

Query: 163 NHETAHNVIC------KTSVLDEHAGRPFLNAANDADLCNL 197
               + N  C      K   + + A + F    N+   C L
Sbjct: 681 RRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQL 721



 Score = 36.6 bits (83), Expect = 0.022
 Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 23/96 (23%)

Query: 68  LLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQS 127
           LL L++N+I  +    F+DL  L +L+L  N ++ I     KG+   LQ+       IQ+
Sbjct: 383 LLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTIS----KGLFAPLQS-------IQT 431

Query: 128 VHKNAFNNLKARARIANNPWHCDCTLQQVLRSMASN 163
           +H            +A NP+ CDC L+ +   +  N
Sbjct: 432 LH------------LAQNPFVCDCHLKWLADYLQDN 455


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 75.5 bits (184), Expect = 4e-14
 Identities = 50/148 (33%), Positives = 70/148 (47%), Gaps = 29/148 (19%)

Query: 32  SMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEI-------- 83
           S CP  C C  +    V CSN  LK +P+ +P +   LYLD NQ T +P E+        
Sbjct: 725 SRCPTECTCLDTV---VRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTL 781

Query: 84  ---------------FKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
                          F ++ QL  L LS N +  I    F G+ ++L+ L L  N I  V
Sbjct: 782 IDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGL-KSLRLLSLHGNDISVV 840

Query: 129 HKNAFNNLKARARIA--NNPWHCDCTLQ 154
            + AFN+L A + +A   NP +CDC +Q
Sbjct: 841 PEGAFNDLSALSHLAIGANPLYCDCNMQ 868



 Score = 68.9 bits (167), Expect = 4e-12
 Identities = 43/113 (38%), Positives = 62/113 (54%), Gaps = 6/113 (5%)

Query: 27  CFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIP-NEIFK 85
           CF   + CP+ C C    G  V CSN  L +IP  +P  T  L L++N+ T +    IFK
Sbjct: 500 CFADLA-CPEKCRCE---GTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFK 555

Query: 86  DLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKA 138
            L QLR +N S N I  I+E AF+G +   + L L+ NR+++V    F  L++
Sbjct: 556 KLPQLRKINFSNNKITDIEEGAFEGASGVNEIL-LTSNRLENVQHKMFKGLES 607



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 51/150 (34%), Positives = 67/150 (44%), Gaps = 31/150 (20%)

Query: 7   WLTRSLSMCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPET 66
           W   SLS+ L     VL IL   +   CP  C CS S    V C    L+ +PR++P  T
Sbjct: 6   WQMLSLSLGL-----VLAILNKVAPQACPAQCSCSGS---TVDCHGLALRSVPRNIPRNT 57

Query: 67  VLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAE------------- 113
             L L+ N IT I    F  L  LRVL L +N I  I+  AF+ + E             
Sbjct: 58  ERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQL 117

Query: 114 ----------TLQTLDLSDNRIQSVHKNAF 133
                      L  LDLS+N+IQ++ + AF
Sbjct: 118 FPELLFLGTAKLYRLDLSENQIQAIPRKAF 147



 Score = 57.8 bits (138), Expect = 9e-09
 Identities = 46/179 (25%), Positives = 69/179 (38%), Gaps = 52/179 (29%)

Query: 34  CPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVL 93
           CP  C CS++    V C    L EIP +LP     + L+ N I  IP   F    +LR +
Sbjct: 273 CPAACTCSNN---IVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRI 329

Query: 94  NLSKNGIEFIDEHAFKGV------------------------------------------ 111
           +LS N I  +   AF+G+                                          
Sbjct: 330 DLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRV 389

Query: 112 -----AETLQTLDLSDNRIQSVHKNAFNNLKA--RARIANNPWHCDCTLQQVLRSMASN 163
                   L  L L DN++Q++ K  F+ L+A     +A NP+ CDC L+ +   + +N
Sbjct: 390 DAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTN 448



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 30/87 (34%), Positives = 50/87 (57%), Gaps = 3/87 (3%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           L L  NQI +IP + F+    ++ L L  N I  I++ AF+ + + L+ L L++N I  +
Sbjct: 132 LDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRD-LEVLTLNNNNITRL 190

Query: 129 HKNAFNNL-KARA-RIANNPWHCDCTL 153
              +FN++ K R  R+ +N  +CDC L
Sbjct: 191 SVASFNHMPKLRTFRLHSNNLYCDCHL 217



 Score = 28.1 bits (61), Expect = 8.0
 Identities = 15/31 (48%), Positives = 17/31 (54%)

Query: 68  LLYLDSNQITSIPNEIFKDLHQLRVLNLSKN 98
           LL L  NQIT++    F  LH L  LNL  N
Sbjct: 634 LLSLYDNQITTVAPGAFDTLHSLSTLNLLAN 664


>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
           sapiens]
          Length = 345

 Score = 74.7 bits (182), Expect = 7e-14
 Identities = 51/148 (34%), Positives = 75/148 (50%), Gaps = 7/148 (4%)

Query: 16  LLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQ 75
           LLL S V+++L       CP  C C SS    V CS   L EIP  LPP+T  L+L  NQ
Sbjct: 5   LLLFSSVIVLL--QVVCSCPDKCYCQSSTNF-VDCSQQGLAEIPSHLPPQTRTLHLQDNQ 61

Query: 76  ITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNN 135
           I  +P   F+ +  L  LNLS N +  +   AF G+ + LQ L+L+ N + S+    F++
Sbjct: 62  IHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGL-QHLQVLNLTQNSLLSLESRLFHS 120

Query: 136 LKARARI---ANNPWHCDCTLQQVLRSM 160
           L     +   +NN  H   +L +   ++
Sbjct: 121 LPQLRELDLSSNNISHLPTSLGETWENL 148


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 50/135 (37%), Positives = 68/135 (50%), Gaps = 4/135 (2%)

Query: 14  MCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDS 73
           + +LL   +L++     A  CP  C CS+     V C   NL+E+P  +   T LL L  
Sbjct: 27  LVVLLALQLLVVAGLVRAQTCPSVCSCSNQFS-KVICVRKNLREVPDGISTNTRLLNLHE 85

Query: 74  NQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAF 133
           NQI  I    FK L  L +L LS+N I  I+  AF G+A  L TL+L DNR+ ++   AF
Sbjct: 86  NQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLA-NLNTLELFDNRLTTIPNGAF 144

Query: 134 NNLKARAR--IANNP 146
             L       + NNP
Sbjct: 145 VYLSKLKELWLRNNP 159



 Score = 37.4 bits (85), Expect = 0.013
 Identities = 28/104 (26%), Positives = 48/104 (46%), Gaps = 29/104 (27%)

Query: 76  ITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNN 135
           +  IPN     L +L  L+LS N +  I   +F+G+   LQ L +  ++IQ + +NAF+N
Sbjct: 209 LREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLMH-LQKLWMIQSQIQVIERNAFDN 265

Query: 136 LKA--------------------------RARIANNPWHCDCTL 153
           L++                          R  + +NPW+C+C +
Sbjct: 266 LQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDI 309


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score = 73.2 bits (178), Expect = 2e-13
 Identities = 45/118 (38%), Positives = 61/118 (51%), Gaps = 4/118 (3%)

Query: 31  ASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQL 90
           A+ CP  C CS+     V C+  +L E+P  +P  T  L L  N I  I  + FK L  L
Sbjct: 54  ATSCPVACSCSNQAS-RVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHL 112

Query: 91  RVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARAR--IANNP 146
            +L LSKN +  I+  AF G+  +L TL+L DNR+ +V   AF  L       + NNP
Sbjct: 113 EILQLSKNLVRKIEVGAFNGL-PSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNP 169



 Score = 38.1 bits (87), Expect = 0.008
 Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 23/83 (27%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           L+L   Q+ +I    F DL  L  LNLS N +  +    F  +           +R++ V
Sbjct: 258 LWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPL-----------HRLERV 306

Query: 129 HKNAFNNLKARARIANNPWHCDC 151
           H N            +NPWHC+C
Sbjct: 307 HLN------------HNPWHCNC 317


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 43/115 (37%), Positives = 58/115 (50%), Gaps = 4/115 (3%)

Query: 34  CPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVL 93
           CP  C CS+     V C+   L E+P+ +P  T  L L  N I  I  + F+ LH L VL
Sbjct: 46  CPSVCSCSNQFS-KVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVL 104

Query: 94  NLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARAR--IANNP 146
            L +N I  I+  AF G+A +L TL+L DN +  +   AF  L       + NNP
Sbjct: 105 QLGRNSIRQIEVGAFNGLA-SLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNP 158



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 30/104 (28%), Positives = 54/104 (51%), Gaps = 6/104 (5%)

Query: 54  NLKEIPRDLPPETVL--LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGV 111
           N+K++P +L P   L  L +  N    I    F  L  L+ L +  + +  I+ +AF G+
Sbjct: 207 NIKDMP-NLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGL 265

Query: 112 AETLQTLDLSDNRIQSVHKNAFNNLK--ARARIANNPWHCDCTL 153
           A  ++ L+L+ N + S+  + F  L+      + +NPW+CDC +
Sbjct: 266 ASLVE-LNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDI 308


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 69.7 bits (169), Expect = 2e-12
 Identities = 59/213 (27%), Positives = 91/213 (42%), Gaps = 54/213 (25%)

Query: 12  LSMCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVL--- 68
           L++ L      L ++     + CP  CLC  +    V C +  L+ +P   P  ++L   
Sbjct: 14  LALVLFCAWGTLAVVAQKPGAGCPSRCLCFRT---TVRCMHLLLEAVPAVAPQTSILDLR 70

Query: 69  --------------------LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAF 108
                               L L++NQI  IP+  F+DL  L+ L L KN I+ ID  AF
Sbjct: 71  FNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAF 130

Query: 109 KGVA---------ETLQTLD--------------LSDNRIQSVHKNAFNNLKA--RARIA 143
           KG+A           ++TLD              L +NRI  +    FN+L++  R R+ 
Sbjct: 131 KGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLD 190

Query: 144 NNPWHCDCT---LQQVLRSMASNHETAHNVICK 173
           +N  HCDC    L  +L++ A +       IC+
Sbjct: 191 SNTLHCDCEILWLADLLKTYAESGNAQAAAICE 223


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score = 67.8 bits (164), Expect = 9e-12
 Identities = 42/126 (33%), Positives = 63/126 (50%), Gaps = 3/126 (2%)

Query: 17  LLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQI 76
           LL   +L++        CP GC CS      V C+      +PRD+PP+TV LY+  N I
Sbjct: 7   LLLPLLLLLALGPGVQGCPSGCQCSQPQ--TVFCTARQGTTVPRDVPPDTVGLYVFENGI 64

Query: 77  TSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNL 136
           T +    F  L  L++L+LS+N I  +    F+ +A  L  LDL+ NR+  +    F  L
Sbjct: 65  TMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLA-NLSNLDLTANRLHEITNETFRGL 123

Query: 137 KARARI 142
           +   R+
Sbjct: 124 RRLERL 129


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 44/146 (30%), Positives = 70/146 (47%), Gaps = 29/146 (19%)

Query: 34  CPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIP------------- 80
           CP+ C C  +    V CSN +L+ +P+ +P     LYLD NQ T +P             
Sbjct: 734 CPQECACLDTV---VRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVD 790

Query: 81  ----------NEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHK 130
                     N  F ++ QL  L LS N ++ I   AF+G+  +L+ L L  N I ++ +
Sbjct: 791 LSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGL-RSLRLLSLHGNDISTLQE 849

Query: 131 NAFNNLKARARIA--NNPWHCDCTLQ 154
             F ++ + + +A   NP +CDC L+
Sbjct: 850 GIFADVTSLSHLAIGANPLYCDCHLR 875



 Score = 65.9 bits (159), Expect = 3e-11
 Identities = 41/112 (36%), Positives = 60/112 (53%), Gaps = 4/112 (3%)

Query: 31  ASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQL 90
           AS CP  C C+   G  V C    L+ IP+++P  T  L L+ N IT I    F  L QL
Sbjct: 31  ASACPALCTCT---GTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQL 87

Query: 91  RVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARARI 142
           RVL L +N I  ++  AF  + E L+ L L+ N++  + +  F N +A +R+
Sbjct: 88  RVLQLMENQIGAVERGAFDDMKE-LERLRLNRNQLHMLPELLFQNNQALSRL 138



 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 51/186 (27%), Positives = 72/186 (38%), Gaps = 52/186 (27%)

Query: 27  CFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKD 86
           C  S+  CP  C CS+     V C    L  IP +LP     + L+ N I SIP   F  
Sbjct: 275 CTLSSGSCPAMCTCSNG---IVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSP 331

Query: 87  LHQLRVLNLSKNGIEFIDEHAFKGV----------------------------------- 111
             +LR ++LS N I  I   AF+G+                                   
Sbjct: 332 YRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNAN 391

Query: 112 ------------AETLQTLDLSDNRIQSVHKNAFNNLKA--RARIANNPWHCDCTLQQVL 157
                        + L  L L DN+IQS+ K  F +L+A     +A NP+ CDC L+ + 
Sbjct: 392 KINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLA 451

Query: 158 RSMASN 163
             + +N
Sbjct: 452 DFLRTN 457



 Score = 61.2 bits (147), Expect = 8e-10
 Identities = 36/109 (33%), Positives = 62/109 (56%), Gaps = 5/109 (4%)

Query: 29  HSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIP-NEIFKDL 87
           +S  +CP  C C ++    V CS+  L +IP  +P  T  L L++N+I+ +    +FK L
Sbjct: 508 NSDVVCPHKCRCEANV---VECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKL 564

Query: 88  HQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNL 136
             L+ +NLS N +  I++ AF+G A ++  L L+ N+++S+    F  L
Sbjct: 565 THLKKINLSNNKVSEIEDGAFEGAA-SVSELHLTANQLESIRSGMFRGL 612



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 31/87 (35%), Positives = 51/87 (58%), Gaps = 3/87 (3%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           L+L +NQ+ SI + +F+ L  LR L L  N I  I   +F G+   ++ L L DN+I +V
Sbjct: 594 LHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGL-RNVRLLSLYDNQITTV 652

Query: 129 HKNAFNNLKARA--RIANNPWHCDCTL 153
              AF+ L++ +   +  NP++C+C L
Sbjct: 653 SPGAFDTLQSLSTLNLLANPFNCNCQL 679


>gi|194018474 leucine rich repeat containing 52 [Homo sapiens]
          Length = 313

 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 43/119 (36%), Positives = 60/119 (50%), Gaps = 6/119 (5%)

Query: 30  SASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQ 89
           S S CP  CLC +     V C+   L E P D+P  T  L+L+ N+ITS+P      L  
Sbjct: 22  SGSKCPNNCLCQAQ---EVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSD 78

Query: 90  LRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLK--ARARIANNP 146
           L  L+   N I  + ++ F GV + +  LDLS N + S+    F+ L    +  IANNP
Sbjct: 79  LVYLDCQNNRIREVMDYTFIGVFKLIY-LDLSSNNLTSISPFTFSVLSNLVQLNIANNP 136


>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score = 65.9 bits (159), Expect = 3e-11
 Identities = 38/120 (31%), Positives = 65/120 (54%), Gaps = 2/120 (1%)

Query: 18  LQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQIT 77
           L ++VL +  +  A+ CP  C+C +   +  +C    L+ +P  +P  +  ++L  N+I+
Sbjct: 11  LLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRIS 70

Query: 78  SIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDN-RIQSVHKNAFNNL 136
            +P   F+    L +L L  N +  ID  AF G+A  L+ LDLSDN +++SV    F+ L
Sbjct: 71  HVPAASFRACRNLTILWLHSNVLARIDAAAFTGLA-LLEQLDLSDNAQLRSVDPATFHGL 129



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 42/130 (32%), Positives = 64/130 (49%), Gaps = 6/130 (4%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           L+L  N+I+S+P   F+ LH L  L L +N +  +  HAF+ +   L TL L  N + ++
Sbjct: 183 LFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGR-LMTLYLFANNLSAL 241

Query: 129 HKNAFNNLKA--RARIANNPWHCDCTLQQVLRSMASNHETAHNVICKTSVLDEHAGRPFL 186
              A   L+A    R+ +NPW CDC  + +   +     ++  V C  S+    AGR   
Sbjct: 242 PTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPC--SLPQRLAGRDLK 299

Query: 187 N-AANDADLC 195
             AAND   C
Sbjct: 300 RLAANDLQGC 309


>gi|4826816 leucine-rich, glioma inactivated 1 precursor [Homo
           sapiens]
          Length = 557

 Score = 65.5 bits (158), Expect = 5e-11
 Identities = 43/166 (25%), Positives = 74/166 (44%), Gaps = 32/166 (19%)

Query: 34  CPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETV------------------------LL 69
           CP  C C+     N  C NA  + IPR +PP+ +                        LL
Sbjct: 42  CPAVCTCTKD---NALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLL 96

Query: 70  YLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVH 129
              SN    I ++ F  L  L  L +  N I+ I  H F+G+ ++L  L L++N +Q++ 
Sbjct: 97  LFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGL-KSLIHLSLANNNLQTLP 155

Query: 130 KNAFNNLKARARI--ANNPWHCDCTLQQVLRSMASNHETAHNVICK 173
           K+ F  L +   +    N ++CDC L+ ++  +   + T  ++ C+
Sbjct: 156 KDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCE 201


>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
           sapiens]
          Length = 581

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 43/121 (35%), Positives = 60/121 (49%), Gaps = 4/121 (3%)

Query: 13  SMCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLD 72
           ++ L++   VL+ +   +   CPKGC C    G  V C +  L+EIP  +    + L L 
Sbjct: 13  AVALVIAPTVLLTMLSSAERGCPKGCRCE---GKMVYCESQKLQEIPSSISAGCLGLSLR 69

Query: 73  SNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNA 132
            N +  +    FK L+QL  L L  N I  IDE+AF G+   L+ L LS NRI     N 
Sbjct: 70  YNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGI-RRLKELILSSNRISYFLNNT 128

Query: 133 F 133
           F
Sbjct: 129 F 129



 Score = 37.0 bits (84), Expect = 0.017
 Identities = 22/68 (32%), Positives = 35/68 (51%), Gaps = 1/68 (1%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           L+L SN + +IP  IF+D   L +L+L  N I  +  + F G+   L+ L L  N+   +
Sbjct: 162 LHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIR-LKELHLEHNQFSKL 220

Query: 129 HKNAFNNL 136
           +   F  L
Sbjct: 221 NLALFPRL 228



 Score = 36.6 bits (83), Expect = 0.022
 Identities = 41/158 (25%), Positives = 68/158 (43%), Gaps = 13/158 (8%)

Query: 51  SNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKG 110
           S  NL   PR +  +   LYL  N+I+ I   +      L+ L+LS N IE     +   
Sbjct: 218 SKLNLALFPRLVSLQN--LYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQ 275

Query: 111 VAETLQTLDLSDNRIQSVHKNAFNNLKA--RARIANNPWHCD---CTLQQVLRSMASNHE 165
               LQ L+L  N++  + +   ++  +     +A N W C    C+L   L+S     E
Sbjct: 276 CVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRE 335

Query: 166 TAHNVICKTSVLDEHAGRPFLNAANDADLCNLPKKTTD 203
             + +IC +    E  G   ++A  +  +C   K TT+
Sbjct: 336 --NTIICASP--KELQGVNVIDAVKNYSICG--KSTTE 367


>gi|4502403 biglycan preproprotein [Homo sapiens]
          Length = 368

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 41/127 (32%), Positives = 59/127 (46%), Gaps = 23/127 (18%)

Query: 31  ASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQL 90
           ++MCP GC C       V CS+  LK +P+++ P+T LL L +N I+ +  + FK L  L
Sbjct: 60  SAMCPFGCHCHLRV---VQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHL 116

Query: 91  RVLNLSKNGIEFIDEHAFK--------------------GVAETLQTLDLSDNRIQSVHK 130
             L L  N I  I E AF                      +  +L  L + DNRI+ V K
Sbjct: 117 YALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPK 176

Query: 131 NAFNNLK 137
             F+ L+
Sbjct: 177 GVFSGLR 183



 Score = 38.1 bits (87), Expect = 0.008
 Identities = 28/78 (35%), Positives = 38/78 (48%), Gaps = 1/78 (1%)

Query: 51  SNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKG 110
           S A L  IP+DLP     L+LD N+I +I  E      +L  L L  N I  I E+    
Sbjct: 216 SEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMI-ENGSLS 274

Query: 111 VAETLQTLDLSDNRIQSV 128
              TL+ L L +N++  V
Sbjct: 275 FLPTLRELHLDNNKLARV 292



 Score = 37.4 bits (85), Expect = 0.013
 Identities = 27/99 (27%), Positives = 42/99 (42%), Gaps = 21/99 (21%)

Query: 51  SNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIE--FIDEHAF 108
           S  +L EIP +LP   V L +  N+I  +P  +F  L  +  + +  N +E    +  AF
Sbjct: 146 SKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAF 205

Query: 109 KG-------------------VAETLQTLDLSDNRIQSV 128
            G                   + ETL  L L  N+IQ++
Sbjct: 206 DGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAI 244


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score = 61.6 bits (148), Expect = 6e-10
 Identities = 37/112 (33%), Positives = 59/112 (52%), Gaps = 4/112 (3%)

Query: 34  CPKGCLCS---SSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQL 90
           CP  C+CS    +  L+V CS+ NL  +P  +P  T  L+LD N ++S+P   F++L  L
Sbjct: 79  CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 138

Query: 91  RVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARARI 142
             LNL    +  ++  A  G+ E L  L L  N+++S+    F +  A A +
Sbjct: 139 GFLNLQGGQLGSLEPQALLGL-ENLCHLHLERNQLRSLALGTFAHTPALASL 189



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 34/98 (34%), Positives = 48/98 (48%), Gaps = 3/98 (3%)

Query: 68  LLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQS 127
           +L L  N I S+    FKDLH L  L L  N I  + E +F+G+ + L+ L L  N++Q 
Sbjct: 332 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQ-LEVLTLDHNQLQE 390

Query: 128 VHKNAFNNLKARARIANNPWHCDCTL-QQVLRSMASNH 164
           V   AF  L     + N   +C   L +QV R +   H
Sbjct: 391 VKAGAFLGL-TNVAVMNLSGNCLRNLPEQVFRGLGKLH 427



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 24/125 (19%)

Query: 65  ETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNR 124
           E + L L SNQ+T +P+ +F+ L +L  L LS+N +  +   A  G  +    LD+S NR
Sbjct: 473 ELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADAL-GPLQRAFWLDVSHNR 531

Query: 125 IQSVHKNAF-------------NNLKA---------RARIANNPWHCDCTLQQVLRSMAS 162
           ++++  +               N+L+          R  +  NPW C C L + LR  A 
Sbjct: 532 LEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPL-KALRDFAL 590

Query: 163 NHETA 167
            + +A
Sbjct: 591 QNPSA 595



 Score = 39.3 bits (90), Expect = 0.003
 Identities = 27/73 (36%), Positives = 36/73 (49%), Gaps = 1/73 (1%)

Query: 64  PETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDN 123
           P    LYLD N I ++    F  L  LR L+LS N +  + E  F G+   L+ L LS N
Sbjct: 280 PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLL-GLRVLRLSHN 338

Query: 124 RIQSVHKNAFNNL 136
            I S+    F +L
Sbjct: 339 AIASLRPRTFKDL 351



 Score = 36.2 bits (82), Expect = 0.029
 Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 1/70 (1%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           L L  N++  +   +F  L +LR L+LS+N +  I  + F  +   LQ L L  N I +V
Sbjct: 237 LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPR-LQKLYLDRNLIAAV 295

Query: 129 HKNAFNNLKA 138
              AF  LKA
Sbjct: 296 APGAFLGLKA 305



 Score = 35.0 bits (79), Expect = 0.065
 Identities = 21/73 (28%), Positives = 40/73 (54%), Gaps = 1/73 (1%)

Query: 64  PETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDN 123
           P    L L +N+++ + + +F+ L  L  LNL  N +  + + AF+G+  +L+ L L+ N
Sbjct: 184 PALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLG-SLRELVLAGN 242

Query: 124 RIQSVHKNAFNNL 136
           R+  +    F+ L
Sbjct: 243 RLAYLQPALFSGL 255



 Score = 35.0 bits (79), Expect = 0.065
 Identities = 23/68 (33%), Positives = 36/68 (52%), Gaps = 1/68 (1%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           L+L+ + +  I    F  L  LR L L  NG+  I+E +  G+AE L+ LDL+ N++  +
Sbjct: 429 LHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLE-LDLTSNQLTHL 487

Query: 129 HKNAFNNL 136
               F  L
Sbjct: 488 PHRLFQGL 495



 Score = 31.6 bits (70), Expect = 0.72
 Identities = 17/65 (26%), Positives = 36/65 (55%), Gaps = 1/65 (1%)

Query: 68  LLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQS 127
           ++ L  N + ++P ++F+ L +L  L+L  + +  I  H F G++  L+ L L DN +  
Sbjct: 404 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLS-GLRRLFLKDNGLVG 462

Query: 128 VHKNA 132
           + + +
Sbjct: 463 IEEQS 467


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score = 61.6 bits (148), Expect = 6e-10
 Identities = 37/112 (33%), Positives = 59/112 (52%), Gaps = 4/112 (3%)

Query: 34  CPKGCLCS---SSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQL 90
           CP  C+CS    +  L+V CS+ NL  +P  +P  T  L+LD N ++S+P   F++L  L
Sbjct: 41  CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100

Query: 91  RVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARARI 142
             LNL    +  ++  A  G+ E L  L L  N+++S+    F +  A A +
Sbjct: 101 GFLNLQGGQLGSLEPQALLGL-ENLCHLHLERNQLRSLALGTFAHTPALASL 151



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 34/98 (34%), Positives = 48/98 (48%), Gaps = 3/98 (3%)

Query: 68  LLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQS 127
           +L L  N I S+    FKDLH L  L L  N I  + E +F+G+ + L+ L L  N++Q 
Sbjct: 294 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQ-LEVLTLDHNQLQE 352

Query: 128 VHKNAFNNLKARARIANNPWHCDCTL-QQVLRSMASNH 164
           V   AF  L     + N   +C   L +QV R +   H
Sbjct: 353 VKAGAFLGL-TNVAVMNLSGNCLRNLPEQVFRGLGKLH 389



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 24/125 (19%)

Query: 65  ETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNR 124
           E + L L SNQ+T +P+ +F+ L +L  L LS+N +  +   A  G  +    LD+S NR
Sbjct: 435 ELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADAL-GPLQRAFWLDVSHNR 493

Query: 125 IQSVHKNAF-------------NNLKA---------RARIANNPWHCDCTLQQVLRSMAS 162
           ++++  +               N+L+          R  +  NPW C C L + LR  A 
Sbjct: 494 LEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPL-KALRDFAL 552

Query: 163 NHETA 167
            + +A
Sbjct: 553 QNPSA 557



 Score = 39.3 bits (90), Expect = 0.003
 Identities = 27/73 (36%), Positives = 36/73 (49%), Gaps = 1/73 (1%)

Query: 64  PETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDN 123
           P    LYLD N I ++    F  L  LR L+LS N +  + E  F G+   L+ L LS N
Sbjct: 242 PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLL-GLRVLRLSHN 300

Query: 124 RIQSVHKNAFNNL 136
            I S+    F +L
Sbjct: 301 AIASLRPRTFKDL 313



 Score = 36.2 bits (82), Expect = 0.029
 Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 1/70 (1%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           L L  N++  +   +F  L +LR L+LS+N +  I  + F  +   LQ L L  N I +V
Sbjct: 199 LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPR-LQKLYLDRNLIAAV 257

Query: 129 HKNAFNNLKA 138
              AF  LKA
Sbjct: 258 APGAFLGLKA 267



 Score = 35.0 bits (79), Expect = 0.065
 Identities = 21/73 (28%), Positives = 40/73 (54%), Gaps = 1/73 (1%)

Query: 64  PETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDN 123
           P    L L +N+++ + + +F+ L  L  LNL  N +  + + AF+G+  +L+ L L+ N
Sbjct: 146 PALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLG-SLRELVLAGN 204

Query: 124 RIQSVHKNAFNNL 136
           R+  +    F+ L
Sbjct: 205 RLAYLQPALFSGL 217



 Score = 35.0 bits (79), Expect = 0.065
 Identities = 23/68 (33%), Positives = 36/68 (52%), Gaps = 1/68 (1%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           L+L+ + +  I    F  L  LR L L  NG+  I+E +  G+AE L+ LDL+ N++  +
Sbjct: 391 LHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLE-LDLTSNQLTHL 449

Query: 129 HKNAFNNL 136
               F  L
Sbjct: 450 PHRLFQGL 457



 Score = 31.6 bits (70), Expect = 0.72
 Identities = 17/65 (26%), Positives = 36/65 (55%), Gaps = 1/65 (1%)

Query: 68  LLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQS 127
           ++ L  N + ++P ++F+ L +L  L+L  + +  I  H F G++  L+ L L DN +  
Sbjct: 366 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLS-GLRRLFLKDNGLVG 424

Query: 128 VHKNA 132
           + + +
Sbjct: 425 IEEQS 429


>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
          Length = 359

 Score = 61.2 bits (147), Expect = 8e-10
 Identities = 42/124 (33%), Positives = 57/124 (45%), Gaps = 23/124 (18%)

Query: 33  MCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRV 92
           +CP  C C       V CS+  L ++P+DLPP+T LL L +N+IT I +  FK+L  L  
Sbjct: 53  VCPFRCQCHLRV---VQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHA 109

Query: 93  LNLSKNGIEFIDEHAF--------------------KGVAETLQTLDLSDNRIQSVHKNA 132
           L L  N I  +   AF                    + + +TLQ L   +N I  V K  
Sbjct: 110 LILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169

Query: 133 FNNL 136
           FN L
Sbjct: 170 FNGL 173



 Score = 44.7 bits (104), Expect = 8e-05
 Identities = 25/81 (30%), Positives = 41/81 (50%), Gaps = 1/81 (1%)

Query: 48  VTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHA 107
           +  ++ N+  IP+ LPP    L+LD N+I+ +     K L+ L  L LS N I  +D  +
Sbjct: 205 IRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGS 264

Query: 108 FKGVAETLQTLDLSDNRIQSV 128
                  L+ L L +N++  V
Sbjct: 265 LANTPH-LRELHLDNNKLTRV 284



 Score = 37.7 bits (86), Expect = 0.010
 Identities = 24/80 (30%), Positives = 41/80 (51%), Gaps = 3/80 (3%)

Query: 51  SNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEF--IDEHAF 108
           S   LKE+P  +P     L    N+IT +    F  L+Q+ V+ L  N ++   I+  AF
Sbjct: 137 SKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAF 196

Query: 109 KGVAETLQTLDLSDNRIQSV 128
           +G+ + L  + ++D  I S+
Sbjct: 197 QGM-KKLSYIRIADTNITSI 215


>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
          Length = 359

 Score = 61.2 bits (147), Expect = 8e-10
 Identities = 42/124 (33%), Positives = 57/124 (45%), Gaps = 23/124 (18%)

Query: 33  MCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRV 92
           +CP  C C       V CS+  L ++P+DLPP+T LL L +N+IT I +  FK+L  L  
Sbjct: 53  VCPFRCQCHLRV---VQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHA 109

Query: 93  LNLSKNGIEFIDEHAF--------------------KGVAETLQTLDLSDNRIQSVHKNA 132
           L L  N I  +   AF                    + + +TLQ L   +N I  V K  
Sbjct: 110 LILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169

Query: 133 FNNL 136
           FN L
Sbjct: 170 FNGL 173



 Score = 44.7 bits (104), Expect = 8e-05
 Identities = 25/81 (30%), Positives = 41/81 (50%), Gaps = 1/81 (1%)

Query: 48  VTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHA 107
           +  ++ N+  IP+ LPP    L+LD N+I+ +     K L+ L  L LS N I  +D  +
Sbjct: 205 IRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGS 264

Query: 108 FKGVAETLQTLDLSDNRIQSV 128
                  L+ L L +N++  V
Sbjct: 265 LANTPH-LRELHLDNNKLTRV 284



 Score = 37.7 bits (86), Expect = 0.010
 Identities = 24/80 (30%), Positives = 41/80 (51%), Gaps = 3/80 (3%)

Query: 51  SNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEF--IDEHAF 108
           S   LKE+P  +P     L    N+IT +    F  L+Q+ V+ L  N ++   I+  AF
Sbjct: 137 SKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAF 196

Query: 109 KGVAETLQTLDLSDNRIQSV 128
           +G+ + L  + ++D  I S+
Sbjct: 197 QGM-KKLSYIRIADTNITSI 215


>gi|31542244 leucine rich repeat and fibronectin type III domain
           containing 5 [Homo sapiens]
          Length = 719

 Score = 61.2 bits (147), Expect = 8e-10
 Identities = 37/107 (34%), Positives = 56/107 (52%), Gaps = 2/107 (1%)

Query: 31  ASMCPKGCLCSS-SGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQ 89
           A +CPK C+C   S  L   C+   L  +P ++   TV L L  N +T+I  + F ++  
Sbjct: 17  AQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTS 76

Query: 90  LRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNL 136
           L  L LS+N I FI  HAF  +   L+ L L+ NR+  +  + F+ L
Sbjct: 77  LVDLTLSRNTISFITPHAFADL-RNLRALHLNSNRLTKITNDMFSGL 122



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 26/74 (35%), Positives = 41/74 (55%), Gaps = 1/74 (1%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           L L++NQ+T I +  F D+  L  L+LS N +E I   A + +  +L TL L  N I ++
Sbjct: 128 LILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMV-SLHTLSLDHNMIDNI 186

Query: 129 HKNAFNNLKARARI 142
            K  F++L    R+
Sbjct: 187 PKGTFSHLHKMTRL 200



 Score = 37.7 bits (86), Expect = 0.010
 Identities = 40/149 (26%), Positives = 62/149 (41%), Gaps = 23/149 (15%)

Query: 54  NLKEIPRDLPPETVLLY---LDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKG 110
           NL+ IP D   + V L+   LD N I +IP   F  LH++  L+++ N ++ +       
Sbjct: 158 NLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQ 217

Query: 111 VAETLQTLDLSDNRIQSVHKNAFNNLKARARIANNPWHCDCTLQQVLR-SMASNHETAHN 169
            A+ L T  +       +  + F           NP HC+C L  + R S   + ET   
Sbjct: 218 RAQVLATSGI-------ISPSTF-----ALSFGGNPLHCNCELLWLRRLSREDDLET--- 262

Query: 170 VICKTSVLDEHAGRPFLNAANDADLCNLP 198
             C +  L    GR F +   +  LC  P
Sbjct: 263 --CASPPL--LTGRYFWSIPEEEFLCEPP 287


>gi|12007646 nyctalopin precursor [Homo sapiens]
          Length = 481

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 36/113 (31%), Positives = 52/113 (46%), Gaps = 1/113 (0%)

Query: 31  ASMCPKGCLCSS-SGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQ 89
           A  CP  C CS+   G +V C  A L  +P +LP E V + LD N +  +    F  L  
Sbjct: 28  ARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPS 87

Query: 90  LRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARARI 142
           LR L+L  N + FI   AFKG+    +     +  ++ +H   F  L    R+
Sbjct: 88  LRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRL 140



 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 30/88 (34%), Positives = 45/88 (51%), Gaps = 3/88 (3%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           L L  N +  +    F DL +L +L L +N I F++E AF+ ++  L  L L+ NR+  +
Sbjct: 259 LNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLL-ALHLNGNRLTVL 317

Query: 129 HKNAFNN--LKARARIANNPWHCDCTLQ 154
              AF       R  +  NPW CDC L+
Sbjct: 318 AWVAFQPGFFLGRLFLFRNPWCCDCRLE 345



 Score = 28.5 bits (62), Expect = 6.1
 Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 3/75 (4%)

Query: 61  DLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDL 120
           +LP    L   D N    +P  + + L  L   +L +  IE +   + +G+   L++L L
Sbjct: 157 ELPALRELAAFD-NLFRRVPGAL-RGLANLTHAHLERGRIEAVASSSLQGLRR-LRSLSL 213

Query: 121 SDNRIQSVHKNAFNN 135
             NR+++VH  AF +
Sbjct: 214 QANRVRAVHAGAFGD 228


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 40/103 (38%), Positives = 52/103 (50%), Gaps = 5/103 (4%)

Query: 34  CPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVL 93
           CP  CLC  S    V C +  L  IP+ +P +T +L L  N+I  IP   FK L  L  L
Sbjct: 24  CPSRCLCFKS---TVRCMHLMLDHIPQ-VPQQTTVLDLRFNRIREIPGSAFKKLKNLNTL 79

Query: 94  NLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNL 136
            L+ N I  I  +AF+G+ E L  L L  N I ++ K  F  L
Sbjct: 80  LLNNNHIRKISRNAFEGL-ENLLYLYLYKNEIHALDKQTFKGL 121



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 32/110 (29%), Positives = 54/110 (49%), Gaps = 6/110 (5%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           LYL  N+I ++  + FK L  L  L +  N +E +    F G    L+ L L +N++  +
Sbjct: 103 LYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETF-GDLLRLERLFLHNNKLSKI 161

Query: 129 HKNAFNNLKA--RARIANNPWHCDCTLQ---QVLRSMASNHETAHNVICK 173
              +F+NL +  R R+ +N   CDC L    ++L+  A +  T     C+
Sbjct: 162 PAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCE 211


>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
           [Homo sapiens]
          Length = 518

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 39/125 (31%), Positives = 63/125 (50%), Gaps = 4/125 (3%)

Query: 10  RSLSMCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLL 69
           + +S+ L+L   +L+++   +   CPK C C    G  V C +    +IP ++   +  L
Sbjct: 10  KGMSVVLVLLPTLLLVMLTGAQRACPKNCRCD---GKIVYCESHAFADIPENISGGSQGL 66

Query: 70  YLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVH 129
            L  N I  + +  F  L+QL  L L  N I  +DE AF+G+   L+ L LS N+I  +H
Sbjct: 67  SLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGI-RRLKELILSSNKITYLH 125

Query: 130 KNAFN 134
              F+
Sbjct: 126 NKTFH 130



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 20/70 (28%), Positives = 38/70 (54%), Gaps = 1/70 (1%)

Query: 67  VLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQ 126
           ++L+L SN + ++P  +F+D   L  L+L  N +  +  +AF G+ + L+ L L  N+  
Sbjct: 160 IILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLK-LKELHLEHNQFS 218

Query: 127 SVHKNAFNNL 136
            ++   F  L
Sbjct: 219 KINFAHFPRL 228



 Score = 38.1 bits (87), Expect = 0.008
 Identities = 32/109 (29%), Positives = 50/109 (45%), Gaps = 8/109 (7%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           +YL  N+I SI   +      L  L+LS N I+ I+   FK     LQ L+L  N++ ++
Sbjct: 234 IYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFK-CLPNLQKLNLDSNKLTNI 292

Query: 129 HKNAFNNLKARARI--ANNPWHCD---CTLQQVLRSMASNHETAHNVIC 172
            +   N   +   I  + N W C    C L   L++   N E+   +IC
Sbjct: 293 SQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKES--TMIC 339


>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
           [Homo sapiens]
          Length = 590

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 39/125 (31%), Positives = 63/125 (50%), Gaps = 4/125 (3%)

Query: 10  RSLSMCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLL 69
           + +S+ L+L   +L+++   +   CPK C C    G  V C +    +IP ++   +  L
Sbjct: 10  KGMSVVLVLLPTLLLVMLTGAQRACPKNCRCD---GKIVYCESHAFADIPENISGGSQGL 66

Query: 70  YLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVH 129
            L  N I  + +  F  L+QL  L L  N I  +DE AF+G+   L+ L LS N+I  +H
Sbjct: 67  SLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGI-RRLKELILSSNKITYLH 125

Query: 130 KNAFN 134
              F+
Sbjct: 126 NKTFH 130



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 20/70 (28%), Positives = 38/70 (54%), Gaps = 1/70 (1%)

Query: 67  VLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQ 126
           ++L+L SN + ++P  +F+D   L  L+L  N +  +  +AF G+ + L+ L L  N+  
Sbjct: 160 IILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLK-LKELHLEHNQFS 218

Query: 127 SVHKNAFNNL 136
            ++   F  L
Sbjct: 219 KINFAHFPRL 228



 Score = 38.1 bits (87), Expect = 0.008
 Identities = 32/109 (29%), Positives = 50/109 (45%), Gaps = 8/109 (7%)

Query: 69  LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSV 128
           +YL  N+I SI   +      L  L+LS N I+ I+   FK     LQ L+L  N++ ++
Sbjct: 234 IYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFK-CLPNLQKLNLDSNKLTNI 292

Query: 129 HKNAFNNLKARARI--ANNPWHCD---CTLQQVLRSMASNHETAHNVIC 172
            +   N   +   I  + N W C    C L   L++   N E+   +IC
Sbjct: 293 SQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKES--TMIC 339


>gi|5901992 keratocan [Homo sapiens]
          Length = 352

 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 40/126 (31%), Positives = 63/126 (50%), Gaps = 23/126 (18%)

Query: 34  CPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVL 93
           CP  C C  S    + C N  LKEIP  +P     LYL +N I +IP + F++  QLR +
Sbjct: 42  CPMECFCPPSFPTALYCENRGLKEIPA-IPSRIWYLYLQNNLIETIPEKPFENATQLRWI 100

Query: 94  NLSKN-----GIE-------------FIDEHAFKGV----AETLQTLDLSDNRIQSVHKN 131
           NL+KN     GIE             F++++  + V      +L+ L L+ N++  + + 
Sbjct: 101 NLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQG 160

Query: 132 AFNNLK 137
            F+NL+
Sbjct: 161 TFSNLE 166



 Score = 39.3 bits (90), Expect = 0.003
 Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 36  KGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNL 95
           KG L      L +   +  L+E+P  LP     L L  N+++ IP   F +L  L +L+L
Sbjct: 114 KGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDL 173

Query: 96  SKNGI--EFIDEHAFKGVAETLQTLDLSDNRIQSV 128
             N +         FKG+   +Q L+++ N ++++
Sbjct: 174 QNNKLVDNAFQRDTFKGLKNLMQ-LNMAKNALRNM 207



 Score = 36.6 bits (83), Expect = 0.022
 Identities = 23/76 (30%), Positives = 38/76 (50%), Gaps = 4/76 (5%)

Query: 55  LKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGI--EFIDEHAFKGVA 112
           L+ +P  LP  T+ L+LD+N I  IP   F  + ++  L L+ N +  E +    F    
Sbjct: 204 LRNMPPRLPANTMQLFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSDEGLPSRGFD--V 261

Query: 113 ETLQTLDLSDNRIQSV 128
            ++  L LS N++  V
Sbjct: 262 SSILDLQLSHNQLTKV 277


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.133    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,097,783
Number of Sequences: 37866
Number of extensions: 357908
Number of successful extensions: 2114
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 149
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 1187
Number of HSP's gapped (non-prelim): 702
length of query: 259
length of database: 18,247,518
effective HSP length: 100
effective length of query: 159
effective length of database: 14,460,918
effective search space: 2299285962
effective search space used: 2299285962
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.