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Search of human proteins with 16117783
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
(605 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 1249 0.0
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 1155 0.0
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 915 0.0
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 912 0.0
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 912 0.0
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 237 3e-62
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 237 3e-62
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 237 3e-62
gi|32189425 WD repeat domain 69 [Homo sapiens] 144 2e-34
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 129 8e-30
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] 126 7e-29
gi|157266266 WD repeat domain 86 [Homo sapiens] 122 7e-28
gi|16554629 WD repeat domain 5 [Homo sapiens] 122 9e-28
gi|16554627 WD repeat domain 5 [Homo sapiens] 122 9e-28
gi|23199987 WD repeat domain 5B [Homo sapiens] 121 2e-27
gi|19913369 transducin beta-like 3 [Homo sapiens] 111 2e-24
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 110 3e-24
gi|113865883 WD repeat domain 38 [Homo sapiens] 109 8e-24
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 106 7e-23
gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens] 103 5e-22
gi|21071067 TBP-associated factor 5 [Homo sapiens] 102 8e-22
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 101 2e-21
gi|19913367 transducin beta-like 1Y [Homo sapiens] 99 9e-21
gi|19913365 transducin beta-like 1Y [Homo sapiens] 99 9e-21
gi|15150805 transducin beta-like 1Y [Homo sapiens] 99 9e-21
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 99 1e-20
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 96 1e-19
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 96 1e-19
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 96 1e-19
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 96 1e-19
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 1249 bits (3231), Expect = 0.0
Identities = 605/605 (100%), Positives = 605/605 (100%)
Query: 1 MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDC 60
MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDC
Sbjct: 1 MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDC 60
Query: 61 NNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIV 120
NNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIV
Sbjct: 61 NNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIV 120
Query: 121 PKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDF 180
PKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDF
Sbjct: 121 PKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDF 180
Query: 181 ITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWR 240
ITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWR
Sbjct: 181 ITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWR 240
Query: 241 GLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRS 300
GLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRS
Sbjct: 241 GLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRS 300
Query: 301 ETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGS 360
ETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGS
Sbjct: 301 ETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGS 360
Query: 361 SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR 420
SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR
Sbjct: 361 SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR 420
Query: 421 VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVV 480
VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVV
Sbjct: 421 VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVV 480
Query: 481 SGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPR 540
SGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPR
Sbjct: 481 SGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPR 540
Query: 541 APAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTY 600
APAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTY
Sbjct: 541 APAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTY 600
Query: 601 TYISR 605
TYISR
Sbjct: 601 TYISR 605
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 1155 bits (2987), Expect = 0.0
Identities = 569/605 (94%), Positives = 569/605 (94%), Gaps = 36/605 (5%)
Query: 1 MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDC 60
MDPAEAVLQEKALKFM NSSEREDC
Sbjct: 1 MDPAEAVLQEKALKFM------------------------------------NSSEREDC 24
Query: 61 NNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIV 120
NNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIV
Sbjct: 25 NNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIV 84
Query: 121 PKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDF 180
PKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDF
Sbjct: 85 PKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDF 144
Query: 181 ITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWR 240
ITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWR
Sbjct: 145 ITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWR 204
Query: 241 GLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRS 300
GLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRS
Sbjct: 205 GLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRS 264
Query: 301 ETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGS 360
ETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGS
Sbjct: 265 ETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGS 324
Query: 361 SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR 420
SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR
Sbjct: 325 SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR 384
Query: 421 VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVV 480
VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVV
Sbjct: 385 VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVV 444
Query: 481 SGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPR 540
SGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPR
Sbjct: 445 SGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPR 504
Query: 541 APAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTY 600
APAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTY
Sbjct: 505 APAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTY 564
Query: 601 TYISR 605
TYISR
Sbjct: 565 TYISR 569
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 915 bits (2366), Expect = 0.0
Identities = 443/529 (83%), Positives = 483/529 (91%), Gaps = 6/529 (1%)
Query: 77 RQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKEL 136
R + CA L E++C A + +++ V +++NGTSS+IV ++R +Y+KEK+L
Sbjct: 20 RSLWLGCANLV---ESMC-ALSCLQSMPSVRCLQISNGTSSVIVSRKRPSEGNYQKEKDL 75
Query: 137 CVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENI 196
C+KYF+QWSESDQVEFVEHLIS+MCHYQHGHINSYLKPMLQRDFITALP +GLDHIAENI
Sbjct: 76 CIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENI 135
Query: 197 LSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNK 256
LSYLDA+SLCAAELVCKEW RV S+GMLWKKLIERMVRTD LW+GL+ERRGW QYLFKN+
Sbjct: 136 LSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNR 195
Query: 257 PPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKI 316
P DG PPNSFYR+LYPKIIQDIETIESNWRCGRH+LQRI CRSE SKGVYCLQYDD+KI
Sbjct: 196 PTDG--PPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKI 253
Query: 317 VSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEML 376
+SGLRDN+IKIWDK +LEC ++LTGHTGSVLCLQYDERVI+TGSSDSTVRVWDVNTGE+L
Sbjct: 254 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL 313
Query: 377 NTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDD 436
NTLIHH EAVLHLRF+NG+MVTCSKDRSIAVWDMAS TDITLRRVLVGHRAAVNVVDFDD
Sbjct: 314 NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD 373
Query: 437 KYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG 496
KYIVSASGDRTIKVW+TSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG
Sbjct: 374 KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG 433
Query: 497 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSG 556
ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL AALDPRAPA TLCLRTLVEHSG
Sbjct: 434 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG 493
Query: 557 RVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTYTYISR 605
RVFRLQFDEFQI+SSSHDDTILIWDFLN P + RSPSRTYTYISR
Sbjct: 494 RVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR 542
Score = 52.0 bits (123), Expect = 2e-06
Identities = 21/40 (52%), Positives = 34/40 (85%), Gaps = 1/40 (2%)
Query: 1 MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCL 40
M+P ++V+++K ++ MCS+PRSLWLGC++L +SM +L CL
Sbjct: 1 MEP-DSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCL 39
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 912 bits (2356), Expect = 0.0
Identities = 436/503 (86%), Positives = 470/503 (93%), Gaps = 2/503 (0%)
Query: 103 ENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCH 162
E+ + ++NGTSS+IV ++R +Y+KEK+LC+KYF+QWSESDQVEFVEHLIS+MCH
Sbjct: 8 EDKTIELMISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCH 67
Query: 163 YQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDG 222
YQHGHINSYLKPMLQRDFITALP +GLDHIAENILSYLDA+SLCAAELVCKEW RV S+G
Sbjct: 68 YQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEG 127
Query: 223 MLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETI 282
MLWKKLIERMVRTD LW+GL+ERRGW QYLFKN+P DG PPNSFYR+LYPKIIQDIETI
Sbjct: 128 MLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDG--PPNSFYRSLYPKIIQDIETI 185
Query: 283 ESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGH 342
ESNWRCGRH+LQRI CRSE SKGVYCLQYDD+KI+SGLRDN+IKIWDK +LEC ++LTGH
Sbjct: 186 ESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGH 245
Query: 343 TGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKD 402
TGSVLCLQYDERVI+TGSSDSTVRVWDVNTGE+LNTLIHH EAVLHLRF+NG+MVTCSKD
Sbjct: 246 TGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKD 305
Query: 403 RSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTL 462
RSIAVWDMAS TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW+TSTCEFVRTL
Sbjct: 306 RSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTL 365
Query: 463 NGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSG 522
NGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSG
Sbjct: 366 NGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSG 425
Query: 523 AYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDF 582
AYDGKIKVWDL AALDPRAPA TLCLRTLVEHSGRVFRLQFDEFQI+SSSHDDTILIWDF
Sbjct: 426 AYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDF 485
Query: 583 LNDPAAQAEPPRSPSRTYTYISR 605
LN P + RSPSRTYTYISR
Sbjct: 486 LNVPPSAQNETRSPSRTYTYISR 508
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 912 bits (2356), Expect = 0.0
Identities = 435/496 (87%), Positives = 468/496 (94%), Gaps = 2/496 (0%)
Query: 110 KLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHIN 169
+++NGTSS+IV ++R +Y+KEK+LC+KYF+QWSESDQVEFVEHLIS+MCHYQHGHIN
Sbjct: 36 QISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHIN 95
Query: 170 SYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLI 229
SYLKPMLQRDFITALP +GLDHIAENILSYLDA+SLCAAELVCKEW RV S+GMLWKKLI
Sbjct: 96 SYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLI 155
Query: 230 ERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCG 289
ERMVRTD LW+GL+ERRGW QYLFKN+P DG PPNSFYR+LYPKIIQDIETIESNWRCG
Sbjct: 156 ERMVRTDPLWKGLSERRGWDQYLFKNRPTDG--PPNSFYRSLYPKIIQDIETIESNWRCG 213
Query: 290 RHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCL 349
RH+LQRI CRSE SKGVYCLQYDD+KI+SGLRDN+IKIWDK +LEC ++LTGHTGSVLCL
Sbjct: 214 RHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL 273
Query: 350 QYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWD 409
QYDERVI+TGSSDSTVRVWDVNTGE+LNTLIHH EAVLHLRF+NG+MVTCSKDRSIAVWD
Sbjct: 274 QYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWD 333
Query: 410 MASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI 469
MAS TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW+TSTCEFVRTLNGHKRGI
Sbjct: 334 MASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI 393
Query: 470 ACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIK 529
ACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIK
Sbjct: 394 ACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIK 453
Query: 530 VWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQ 589
VWDL AALDPRAPA TLCLRTLVEHSGRVFRLQFDEFQI+SSSHDDTILIWDFLN P +
Sbjct: 454 VWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSA 513
Query: 590 AEPPRSPSRTYTYISR 605
RSPSRTYTYISR
Sbjct: 514 QNETRSPSRTYTYISR 529
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 237 bits (604), Expect = 3e-62
Identities = 145/447 (32%), Positives = 231/447 (51%), Gaps = 37/447 (8%)
Query: 138 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENIL 197
+K F+ WS +++ ++ LI Q H+ ++P QRDFI+ LP +A +L
Sbjct: 120 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 175
Query: 198 SYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKP 257
S+L+ K L A C+ W + D +LW++ + + L +RR KP
Sbjct: 176 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH---IKRRK------VIKP 226
Query: 258 PDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIV 317
++P S Y + I++NWR G ++ + + CLQ+ +IV
Sbjct: 227 GFIHSPWKSAYIRQH--------RIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIV 277
Query: 318 SGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLN 377
SG DNT+K+W T +C R L GHTG V Q + +II+GS+D T++VW+ TGE ++
Sbjct: 278 SGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIH 337
Query: 378 TLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK 437
TL H V + + +V+ S+D ++ VWD+ + + VL+GH AAV V +D +
Sbjct: 338 TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGR 394
Query: 438 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGA 497
+VS + D +KVW+ T + TL GH + LQ+ VVSGS D +IR+WD+E G
Sbjct: 395 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGN 454
Query: 498 CLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLV---EH 554
C+ L GH+ L + + +VSG D +K+WD+ CL+TL +H
Sbjct: 455 CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKH 505
Query: 555 SGRVFRLQFDEFQIVSSSHDDTILIWD 581
V LQF++ +++SS D T+ +WD
Sbjct: 506 QSAVTCLQFNKNFVITSSDDGTVKLWD 532
Score = 152 bits (385), Expect = 7e-37
Identities = 84/251 (33%), Positives = 138/251 (54%), Gaps = 17/251 (6%)
Query: 296 IHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV 355
IH + V C+ ++++VSG RD T+++WD T +C +L GH +V C+QYD R
Sbjct: 336 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR 395
Query: 356 IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTD 415
+++G+ D V+VWD T L+TL H V L+F+ +V+ S D SI VWD+ +
Sbjct: 396 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNC 455
Query: 416 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG---HKRGIACL 472
I L GH++ + ++ D +VS + D T+K+W+ T + ++TL G H+ + CL
Sbjct: 456 I---HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 512
Query: 473 QYRDRLVVSGSSDNTIRLWDIECGACLRVL-----EGHEELVRCIRFDNKRIV------S 521
Q+ V++ S D T++LWD++ G +R L G +V IR N ++V +
Sbjct: 513 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 572
Query: 522 GAYDGKIKVWD 532
G + K+ V D
Sbjct: 573 GTEETKLLVLD 583
Score = 32.7 bits (73), Expect = 0.99
Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 4/59 (6%)
Query: 293 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRIL----TGHTGSVL 347
LQ + ++ V CLQ++ +++ D T+K+WD T E R L +G +G V+
Sbjct: 496 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 554
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 237 bits (604), Expect = 3e-62
Identities = 145/447 (32%), Positives = 231/447 (51%), Gaps = 37/447 (8%)
Query: 138 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENIL 197
+K F+ WS +++ ++ LI Q H+ ++P QRDFI+ LP +A +L
Sbjct: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293
Query: 198 SYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKP 257
S+L+ K L A C+ W + D +LW++ + + L +RR KP
Sbjct: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH---IKRRK------VIKP 344
Query: 258 PDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIV 317
++P S Y + I++NWR G ++ + + CLQ+ +IV
Sbjct: 345 GFIHSPWKSAYIRQH--------RIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIV 395
Query: 318 SGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLN 377
SG DNT+K+W T +C R L GHTG V Q + +II+GS+D T++VW+ TGE ++
Sbjct: 396 SGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIH 455
Query: 378 TLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK 437
TL H V + + +V+ S+D ++ VWD+ + + VL+GH AAV V +D +
Sbjct: 456 TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGR 512
Query: 438 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGA 497
+VS + D +KVW+ T + TL GH + LQ+ VVSGS D +IR+WD+E G
Sbjct: 513 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGN 572
Query: 498 CLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLV---EH 554
C+ L GH+ L + + +VSG D +K+WD+ CL+TL +H
Sbjct: 573 CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKH 623
Query: 555 SGRVFRLQFDEFQIVSSSHDDTILIWD 581
V LQF++ +++SS D T+ +WD
Sbjct: 624 QSAVTCLQFNKNFVITSSDDGTVKLWD 650
Score = 152 bits (385), Expect = 7e-37
Identities = 84/251 (33%), Positives = 138/251 (54%), Gaps = 17/251 (6%)
Query: 296 IHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV 355
IH + V C+ ++++VSG RD T+++WD T +C +L GH +V C+QYD R
Sbjct: 454 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR 513
Query: 356 IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTD 415
+++G+ D V+VWD T L+TL H V L+F+ +V+ S D SI VWD+ +
Sbjct: 514 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNC 573
Query: 416 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG---HKRGIACL 472
I L GH++ + ++ D +VS + D T+K+W+ T + ++TL G H+ + CL
Sbjct: 574 I---HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630
Query: 473 QYRDRLVVSGSSDNTIRLWDIECGACLRVL-----EGHEELVRCIRFDNKRIV------S 521
Q+ V++ S D T++LWD++ G +R L G +V IR N ++V +
Sbjct: 631 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 690
Query: 522 GAYDGKIKVWD 532
G + K+ V D
Sbjct: 691 GTEETKLLVLD 701
Score = 32.7 bits (73), Expect = 0.99
Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 4/59 (6%)
Query: 293 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRIL----TGHTGSVL 347
LQ + ++ V CLQ++ +++ D T+K+WD T E R L +G +G V+
Sbjct: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 237 bits (604), Expect = 3e-62
Identities = 145/447 (32%), Positives = 231/447 (51%), Gaps = 37/447 (8%)
Query: 138 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENIL 197
+K F+ WS +++ ++ LI Q H+ ++P QRDFI+ LP +A +L
Sbjct: 158 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 213
Query: 198 SYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKP 257
S+L+ K L A C+ W + D +LW++ + + L +RR KP
Sbjct: 214 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH---IKRRK------VIKP 264
Query: 258 PDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIV 317
++P S Y + I++NWR G ++ + + CLQ+ +IV
Sbjct: 265 GFIHSPWKSAYIRQH--------RIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIV 315
Query: 318 SGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLN 377
SG DNT+K+W T +C R L GHTG V Q + +II+GS+D T++VW+ TGE ++
Sbjct: 316 SGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIH 375
Query: 378 TLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK 437
TL H V + + +V+ S+D ++ VWD+ + + VL+GH AAV V +D +
Sbjct: 376 TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGR 432
Query: 438 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGA 497
+VS + D +KVW+ T + TL GH + LQ+ VVSGS D +IR+WD+E G
Sbjct: 433 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGN 492
Query: 498 CLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLV---EH 554
C+ L GH+ L + + +VSG D +K+WD+ CL+TL +H
Sbjct: 493 CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKH 543
Query: 555 SGRVFRLQFDEFQIVSSSHDDTILIWD 581
V LQF++ +++SS D T+ +WD
Sbjct: 544 QSAVTCLQFNKNFVITSSDDGTVKLWD 570
Score = 152 bits (385), Expect = 7e-37
Identities = 84/251 (33%), Positives = 138/251 (54%), Gaps = 17/251 (6%)
Query: 296 IHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV 355
IH + V C+ ++++VSG RD T+++WD T +C +L GH +V C+QYD R
Sbjct: 374 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR 433
Query: 356 IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTD 415
+++G+ D V+VWD T L+TL H V L+F+ +V+ S D SI VWD+ +
Sbjct: 434 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNC 493
Query: 416 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG---HKRGIACL 472
I L GH++ + ++ D +VS + D T+K+W+ T + ++TL G H+ + CL
Sbjct: 494 I---HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 550
Query: 473 QYRDRLVVSGSSDNTIRLWDIECGACLRVL-----EGHEELVRCIRFDNKRIV------S 521
Q+ V++ S D T++LWD++ G +R L G +V IR N ++V +
Sbjct: 551 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 610
Query: 522 GAYDGKIKVWD 532
G + K+ V D
Sbjct: 611 GTEETKLLVLD 621
Score = 32.7 bits (73), Expect = 0.99
Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 4/59 (6%)
Query: 293 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRIL----TGHTGSVL 347
LQ + ++ V CLQ++ +++ D T+K+WD T E R L +G +G V+
Sbjct: 534 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 592
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 144 bits (364), Expect = 2e-34
Identities = 87/290 (30%), Positives = 149/290 (51%), Gaps = 27/290 (9%)
Query: 306 VYCLQYDD---QKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGS 360
VY + +++ KI +G D T K+W T +C GHT ++CL ++ + ++ TGS
Sbjct: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGS 196
Query: 361 SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG--MMVTCSKDRSIAVWDMASPTDITL 418
D+T ++WD+ GE + TL H ++ L FN ++T S D ++ VWD + +
Sbjct: 197 MDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV-- 254
Query: 419 RRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQY 474
+L+GH A ++ F D I++ S D+T K+W+ + + V TL GH I +C Y
Sbjct: 255 -NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313
Query: 475 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWD 532
+L+ + S+D T R++ C+ LEGHE + I F+ +++G+ D ++WD
Sbjct: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Query: 533 LVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIW 580
A G CL+ L H+ +F F+ +++ S D+T IW
Sbjct: 374 --------AQTGQ-CLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 94.7 bits (234), Expect = 2e-19
Identities = 64/205 (31%), Positives = 98/205 (47%), Gaps = 21/205 (10%)
Query: 389 LRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY---IVSASGD 445
L + +T S DR+ +WD AS ++ L GHR V + F++ Y I + S D
Sbjct: 100 LNKSGSCFITGSYDRTCKLWDTASGEEL---NTLEGHRNVVYAIAFNNPYGDKIATGSFD 156
Query: 446 RTIKVWNTSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLE 503
+T K+W+ T + T GH I CL + + LV +GS D T +LWDI+ G + L
Sbjct: 157 KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Query: 504 GHEELVRCIRFDNK--RIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL 561
GH + + F+ RI++G++D + VWD A G + L+ H +
Sbjct: 217 GHSAEIISLSFNTSGDRIITGSFDHTVVVWD--------ADTGRK-VNILIGHCAEISSA 267
Query: 562 QF--DEFQIVSSSHDDTILIWDFLN 584
F D I++ S D T +WD N
Sbjct: 268 SFNWDCSLILTGSMDKTCKLWDATN 292
Score = 94.0 bits (232), Expect = 4e-19
Identities = 73/236 (30%), Positives = 111/236 (47%), Gaps = 25/236 (10%)
Query: 357 ITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNN---GMMVTCSKDRSIAVWDMASP 413
ITGS D T ++WD +GE LNTL H V + FNN + T S D++ +W + +
Sbjct: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167
Query: 414 TDITLRRVLVGHRAAVNVVDFDDKYIVSASG--DRTIKVWNTSTCEFVRTLNGHKRGIAC 471
R GH A + + F+ + + A+G D T K+W+ E V TL GH I
Sbjct: 168 KCYHTFR---GHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIIS 224
Query: 472 LQYR---DRLVVSGSSDNTIRLWDIECGACLRVLEGH--EELVRCIRFDNKRIVSGAYDG 526
L + DR +++GS D+T+ +WD + G + +L GH E +D I++G+ D
Sbjct: 225 LSFNTSGDR-IITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDK 283
Query: 527 KIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF--QIVSSSHDDTILIW 580
K+WD C+ TL H + FD I ++S D T I+
Sbjct: 284 TCKLWD---------ATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF 330
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 129 bits (324), Expect = 8e-30
Identities = 87/298 (29%), Positives = 144/298 (48%), Gaps = 44/298 (14%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTG 373
+VS D TIK+WD T + +R L GHT SV + +D +++ + S+D T+++WD
Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
Query: 374 EMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 431
E + T+ H V + N +V+ S+D++I +W++ + + + GHR V +
Sbjct: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV---KTFTGHREWVRM 239
Query: 432 V--DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR------------ 477
V + D I S S D+T++VW +T E L H+ + C+ +
Sbjct: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299
Query: 478 ----------LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYD 525
++SGS D TI++WD+ G CL L GH+ VR + F + K I+S A D
Sbjct: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADD 359
Query: 526 GKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF--QIVSSSHDDTILIWD 581
++VWD C++TL H V L F + +V+ S D T+ +W+
Sbjct: 360 KTLRVWDY---------KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 115 bits (288), Expect = 1e-25
Identities = 83/281 (29%), Positives = 135/281 (48%), Gaps = 44/281 (15%)
Query: 336 KRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNN 393
K L+GH V + + V+++ S D+T++VWD TG+ TL H ++V + F++
Sbjct: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160
Query: 394 G--MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIK 449
++ +CS D +I +WD I R + GH V+ V + +IVSAS D+TIK
Sbjct: 161 SGKLLASCSADMTIKLWDFQGFECI---RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIK 217
Query: 450 VWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEE 507
+W T V+T GH+ + ++ L+ S S+D T+R+W + C L HE
Sbjct: 218 MWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEH 277
Query: 508 LVRCIRF---------------DNKR-------IVSGAYDGKIKVWDLVAALDPRAPAGT 545
+V CI + + K+ ++SG+ D IK+WD+
Sbjct: 278 VVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG--------- 328
Query: 546 LCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIWDFLN 584
+CL TLV H V + F I+S + D T+ +WD+ N
Sbjct: 329 MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369
Score = 75.1 bits (183), Expect = 2e-13
Identities = 48/166 (28%), Positives = 78/166 (46%), Gaps = 29/166 (17%)
Query: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER----------------- 354
D I S D T+++W T ECK L H V C+ +
Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304
Query: 355 -----VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG--MMVTCSKDRSIAV 407
+++GS D T+++WDV+TG L TL+ H V + F++G +++C+ D+++ V
Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRV 364
Query: 408 WDMASPTDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVW 451
WD + + L H V +DF Y+V+ S D+T+KVW
Sbjct: 365 WDYKNK---RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
Length = 670
Score = 126 bits (316), Expect = 7e-29
Identities = 79/278 (28%), Positives = 135/278 (48%), Gaps = 17/278 (6%)
Query: 308 CLQYDDQKIVSGLRDNTIKIWDK-NTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVR 366
C+ + SG D TIK+WD T +C++ L GH G VL L + +GS+D T+
Sbjct: 403 CVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTII 462
Query: 367 VWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHR 426
VWD+ + +NT+ H V L ++ ++ + S ++I VWD+ T++ L++ L G
Sbjct: 463 VWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIKVWDIVG-TELKLKKELTGLN 520
Query: 427 AAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDN 486
V + Y+ S S +TIK+W+ T + + L + + + +V G+ +N
Sbjct: 521 HWVRALVAAQSYLYSGS-YQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYEN 579
Query: 487 TIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLVAALDPRAP 542
I +WDIE +R L GH V + D ++ S +YD ++VW +
Sbjct: 580 LIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSM--------- 630
Query: 543 AGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIW 580
+C +TL+ H G V L ++ S + D T+ +W
Sbjct: 631 DNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
Score = 64.3 bits (155), Expect = 3e-10
Identities = 36/121 (29%), Positives = 59/121 (48%), Gaps = 4/121 (3%)
Query: 292 SLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY 351
+L IH + VY + + IV G +N I +WD + E R LTGH G+V L
Sbjct: 548 TLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAV 607
Query: 352 ----DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAV 407
D+ + + S D ++RVW ++ TL+ H +V L + G + + + D ++ V
Sbjct: 608 ISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKV 667
Query: 408 W 408
W
Sbjct: 668 W 668
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/89 (31%), Positives = 37/89 (41%), Gaps = 10/89 (11%)
Query: 498 CLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHS 555
C GH+ V C+ + SG+ D IKVWD C +TL H
Sbjct: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYK--------CQKTLEGHD 439
Query: 556 GRVFRLQFDEFQIVSSSHDDTILIWDFLN 584
G V L ++ S S D TI++WD N
Sbjct: 440 GIVLALCIQGCKLYSGSADCTIIVWDIQN 468
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 122 bits (307), Expect = 7e-28
Identities = 98/344 (28%), Positives = 143/344 (41%), Gaps = 54/344 (15%)
Query: 309 LQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVW 368
L D Q++++G D T ++W +C +L GH V Q ++ T S+D T+R W
Sbjct: 23 LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82
Query: 369 DVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 428
DV TG+ L H V + N + + S DR+ VW + + R GHR
Sbjct: 83 DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139
Query: 429 VNVVDFDDKY----------------IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIAC- 471
V + + + +V+ S D T KVW ++ +TL GH + C
Sbjct: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
Query: 472 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 530
L +GS+D TIR WDI G LRV H V C+ N+ + SG+ D +K
Sbjct: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259
Query: 531 W---------------DLVAALDPRA-----PAGTLCLRTLVEHSG---RVFR------- 560
W V+AL A +G C R SG RVFR
Sbjct: 260 WLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIIN 319
Query: 561 -LQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPP--RSPSRTYT 601
+Q + ++SHD + +WD A PP RS SR ++
Sbjct: 320 CIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSRLFS 363
Score = 108 bits (271), Expect = 1e-23
Identities = 73/264 (27%), Positives = 114/264 (43%), Gaps = 32/264 (12%)
Query: 337 RILTGHTGSV--LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG 394
R+ H G + L L D + ++TGS D T R+W G+ L H V + +
Sbjct: 9 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 68
Query: 395 MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTS 454
TCS D +I WD+ + + + R GH + VN + + + S+S DRT +VW+
Sbjct: 69 AAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSVD 125
Query: 455 TCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGAC 498
+ R GH+ + L Y L+V+GS+D T ++W + G C
Sbjct: 126 KGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCC 185
Query: 499 LRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSG 556
+ L GH V C+ D +G+ D I+ WD+++ LR EH G
Sbjct: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHRG 236
Query: 557 RVFRLQFDEFQIVSSSHDDTILIW 580
V L+ + S S D T+ W
Sbjct: 237 SVICLELVNRLVYSGSADRTVKCW 260
Score = 67.8 bits (164), Expect = 3e-11
Identities = 32/105 (30%), Positives = 55/105 (52%)
Query: 306 VYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTV 365
V CL+ ++ + SG D T+K W +T EC R T H +V L+Y + TGS D+
Sbjct: 238 VICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACA 297
Query: 366 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDM 410
R +D +GE+ H + ++ + ++ T S D ++ +WD+
Sbjct: 298 RAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342
Score = 45.8 bits (107), Expect = 1e-04
Identities = 21/67 (31%), Positives = 36/67 (53%)
Query: 304 KGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDS 363
+ V L+Y + +G D + +D + E +R+ GHT + C+Q +V+ T S D
Sbjct: 276 RNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDG 335
Query: 364 TVRVWDV 370
+R+WDV
Sbjct: 336 ALRLWDV 342
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 122 bits (306), Expect = 9e-28
Identities = 77/237 (32%), Positives = 130/237 (54%), Gaps = 21/237 (8%)
Query: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWD 369
D +VS D T+KIWD ++ +C + L GH+ V C ++ + +I++GS D +VR+WD
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 370 VNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRA 427
V TG+ L TL H + V + FN ++V+ S D +WD AS L+ ++
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215
Query: 428 AVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 480
V+ V F + KYI++A+ D T+K+W+ S + ++T GHK C+ + +V
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 481 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 531
SGS DN + +W+++ ++ L+GH ++V C +N I++ A D IK+W
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330
Score = 111 bits (278), Expect = 2e-24
Identities = 63/172 (36%), Positives = 97/172 (56%), Gaps = 17/172 (9%)
Query: 418 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR 475
L+ L GH AV+ V F + +++ S+S D+ IK+W +F +T++GHK GI+ + +
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 476 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 531
L+VS S D T+++WD+ G CL+ L+GH V C F+ + IVSG++D +++W
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 532 DLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 581
D+ CL+TL HS V + F D IVSSS+D IWD
Sbjct: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 106 bits (264), Expect = 7e-23
Identities = 67/233 (28%), Positives = 125/233 (53%), Gaps = 19/233 (8%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 373
+ S D IKIW + ++ ++GH + + + D ++++ S D T+++WDV++G
Sbjct: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119
Query: 374 EMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 431
+ L TL H V FN + ++V+ S D S+ +WD+ + + + L H V+
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPVSA 176
Query: 432 VDF--DDKYIVSASGDRTIKVWNTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSSDN 486
V F D IVS+S D ++W+T++ + ++TL + ++ +++ + +++ + DN
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN 236
Query: 487 TIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDL 533
T++LWD G CL+ GH+ CI F N K IVSG+ D + +W+L
Sbjct: 237 TLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 58.2 bits (139), Expect = 2e-08
Identities = 39/151 (25%), Positives = 71/151 (47%), Gaps = 15/151 (9%)
Query: 461 TLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DN 516
TL GH + ++ +++ + S S+D I++W G + + GH+ + + + D+
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 517 KRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHD 574
+VS + D +K+WD+ + CL+TL HS VF F+ IVS S D
Sbjct: 100 NLLVSASDDKTLKIWDVSSGK---------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 575 DTILIWDFLNDPAAQAEPPRSPSRTYTYISR 605
+++ IWD + P S + + +R
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR 181
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 122 bits (306), Expect = 9e-28
Identities = 77/237 (32%), Positives = 130/237 (54%), Gaps = 21/237 (8%)
Query: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWD 369
D +VS D T+KIWD ++ +C + L GH+ V C ++ + +I++GS D +VR+WD
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 370 VNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRA 427
V TG+ L TL H + V + FN ++V+ S D +WD AS L+ ++
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215
Query: 428 AVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 480
V+ V F + KYI++A+ D T+K+W+ S + ++T GHK C+ + +V
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 481 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 531
SGS DN + +W+++ ++ L+GH ++V C +N I++ A D IK+W
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330
Score = 111 bits (278), Expect = 2e-24
Identities = 63/172 (36%), Positives = 97/172 (56%), Gaps = 17/172 (9%)
Query: 418 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR 475
L+ L GH AV+ V F + +++ S+S D+ IK+W +F +T++GHK GI+ + +
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 476 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 531
L+VS S D T+++WD+ G CL+ L+GH V C F+ + IVSG++D +++W
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 532 DLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 581
D+ CL+TL HS V + F D IVSSS+D IWD
Sbjct: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 106 bits (264), Expect = 7e-23
Identities = 67/233 (28%), Positives = 125/233 (53%), Gaps = 19/233 (8%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 373
+ S D IKIW + ++ ++GH + + + D ++++ S D T+++WDV++G
Sbjct: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119
Query: 374 EMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 431
+ L TL H V FN + ++V+ S D S+ +WD+ + + + L H V+
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPVSA 176
Query: 432 VDF--DDKYIVSASGDRTIKVWNTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSSDN 486
V F D IVS+S D ++W+T++ + ++TL + ++ +++ + +++ + DN
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN 236
Query: 487 TIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDL 533
T++LWD G CL+ GH+ CI F N K IVSG+ D + +W+L
Sbjct: 237 TLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 58.2 bits (139), Expect = 2e-08
Identities = 39/151 (25%), Positives = 71/151 (47%), Gaps = 15/151 (9%)
Query: 461 TLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DN 516
TL GH + ++ +++ + S S+D I++W G + + GH+ + + + D+
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 517 KRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHD 574
+VS + D +K+WD+ + CL+TL HS VF F+ IVS S D
Sbjct: 100 NLLVSASDDKTLKIWDVSSGK---------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 575 DTILIWDFLNDPAAQAEPPRSPSRTYTYISR 605
+++ IWD + P S + + +R
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR 181
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 121 bits (303), Expect = 2e-27
Identities = 77/236 (32%), Positives = 127/236 (53%), Gaps = 19/236 (8%)
Query: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWD 369
D ++VS D T+K+WD + +C + L GH+ V C ++ +II+GS D TV++W+
Sbjct: 94 DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
Query: 370 VNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRA 427
V TG+ L TL H + V + FN ++V+ S D +WD AS L+ ++
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ--CLKTLVDDDNP 211
Query: 428 AVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 480
V+ V F + KYI++A+ D T+K+W+ S ++T GHK C+ + +V
Sbjct: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIV 271
Query: 481 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGAY--DGKIKVW 531
SGS DN + +W+++ ++ L+GH ++V C +N I S A D IK+W
Sbjct: 272 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN-LIASAALENDKTIKLW 326
Score = 98.2 bits (243), Expect = 2e-20
Identities = 59/172 (34%), Positives = 92/172 (53%), Gaps = 17/172 (9%)
Query: 418 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR 475
L+ LVGH AV+ V F + +++ S+S DR I +W ++ +TL GH I+ + +
Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 476 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 531
+VS S D T++LWD+ G CL+ L+GH V C F+ + I+SG++D +K+W
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 532 DLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD--EFQIVSSSHDDTILIWD 581
++ CL+TL HS V + F+ IVS S+D IWD
Sbjct: 153 EVKTG---------KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Score = 92.8 bits (229), Expect = 8e-19
Identities = 62/233 (26%), Positives = 119/233 (51%), Gaps = 19/233 (8%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 373
+ S D I IW + ++ L GH + + + D +++ S D T+++WDV +G
Sbjct: 56 LASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG 115
Query: 374 EMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 431
+ L TL H V FN + ++++ S D ++ +W++ + + + L H V+
Sbjct: 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCL---KTLSAHSDPVSA 172
Query: 432 VDFD--DKYIVSASGDRTIKVWNTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSSDN 486
V F+ IVS S D ++W+ ++ + ++TL + ++ +++ + +++ + DN
Sbjct: 173 VHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDN 232
Query: 487 TIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDL 533
T++LWD G CL+ GH+ CI F N K IVSG+ D + +W+L
Sbjct: 233 TLKLWDYSRGRCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNL 284
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 111 bits (278), Expect = 2e-24
Identities = 83/321 (25%), Positives = 151/321 (47%), Gaps = 41/321 (12%)
Query: 300 SETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VII 357
SE V L +D +V +K+++ T C+ IL GHT VL L + +
Sbjct: 334 SEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQ-ILHGHTDIVLALDVFRKGWLFA 392
Query: 358 TGSSDSTVRVWDVNTGEMLNTLI------HHCEAVLHLRFNNGMMVTCSKDRSIAVWDMA 411
+ + D +VR+W +N + + H V R +VT S+D ++ +W +
Sbjct: 393 SCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLP 452
Query: 412 S------------PTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCE 457
P + + H +N V +DK + + S DRT K+W C+
Sbjct: 453 KALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQ 512
Query: 458 FVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD 515
+ +GH+RG+ C+Q+ D+++ + S+D TI+LW ++ +CL+ EGH+ V + F
Sbjct: 513 LLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFV 572
Query: 516 NK--RIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL---QFDEFQIVS 570
++ +++S DG +K+W + C+RTL H +V+ L + D+ +
Sbjct: 573 SRGTQLLSSGSDGLVKLWTI---------KNNECVRTLDAHEDKVWGLHCSRLDDHALTG 623
Query: 571 SSHDDTILIWDFLNDPAAQAE 591
+S D +++W + + A QAE
Sbjct: 624 AS-DSRVILWKDVTE-AEQAE 642
Score = 50.1 bits (118), Expect = 6e-06
Identities = 49/241 (20%), Positives = 100/241 (41%), Gaps = 23/241 (9%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYD----ERVIITGSSDSTVRVWDVN 371
+ +G D +++WD G G V + + ++ + ++D+ +RVW +
Sbjct: 124 LATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQ 183
Query: 372 TGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAV 429
L L H AV L F + M++ +D+ +WD+ S V AAV
Sbjct: 184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAV 243
Query: 430 NV---------VDFDDKYIVSASGDRTIKVWNTSTCEFVRTL-----NGHKRGIACLQYR 475
+ V Y ++A T++VW ++ + V T G + L +
Sbjct: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
Query: 476 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF---DNKRIVSGAYDGKIKVWD 532
+V++ ++D+ + L++ + G+ E V +RF ++ +V + +KV++
Sbjct: 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFE 363
Query: 533 L 533
L
Sbjct: 364 L 364
Score = 48.1 bits (113), Expect = 2e-05
Identities = 43/180 (23%), Positives = 77/180 (42%), Gaps = 13/180 (7%)
Query: 365 VRVWDVNTGEMLNTLIHHCE---AVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRV 421
V + +V +G +L +L + L +N ++VT S+ +A W + L +
Sbjct: 47 VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKA 106
Query: 422 LVGHRAAVNVVDFDDKYIVSASG--DRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-- 477
+ H A V + FD + A+G D ++VW+ G + + +
Sbjct: 107 I--HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164
Query: 478 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 533
L+ S ++D IR+W ++ +CL VL H V + F D ++S D +WDL
Sbjct: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224
Score = 48.1 bits (113), Expect = 2e-05
Identities = 49/216 (22%), Positives = 91/216 (42%), Gaps = 32/216 (14%)
Query: 309 LQYDDQKIVSGLRDNTIKIWDKNTLECKRILTG-HTGSVLCLQYD--ERVIITGSSDSTV 365
L D++ +V+ R + W R+ HT V + +D ++ TG D V
Sbjct: 74 LSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAV 133
Query: 366 RVWDVNTGEMLNTLIHH---CEAVLHL-RFNNG----MMVTCSKDRSIAVWDMASPTDIT 417
RVWD+ + + HH V+HL F+ ++ + + D +I VW + D +
Sbjct: 134 RVWDI----VRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSL---QDRS 186
Query: 418 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR 475
VL H +AV + F D ++S+ D+ +W+ +C+ RT+ + A +
Sbjct: 187 CLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLP 246
Query: 476 DRLV------------VSGSSDNTIRLWDIECGACL 499
+ V ++ T+R+W+ G C+
Sbjct: 247 EEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCV 282
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 110 bits (276), Expect = 3e-24
Identities = 74/267 (27%), Positives = 129/267 (48%), Gaps = 53/267 (19%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY-DERVIITGSSDSTVRVWDVNTGE 374
+ S +D +++IWD C+RILTGHT SV CL++ + ++ + S D T++VW + G
Sbjct: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGV 278
Query: 375 MLNTLIHH----------------------CEAVLHLRFNNG------------------ 394
+ TL H EA ++ + G
Sbjct: 279 LCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRG 338
Query: 395 ----MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTI 448
+V+ S D ++ +W A R + GH+A +N V F D + + SAS D++I
Sbjct: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTR--MTGHQALINQVLFSPDSRIVASASFDKSI 396
Query: 449 KVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 506
K+W+ T +++ +L GH + + + RL+VSGSSD+T+++WD++ L GH
Sbjct: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 456
Query: 507 ELVRCIRF--DNKRIVSGAYDGKIKVW 531
+ V + + D +R+ SG D +++W
Sbjct: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 94.7 bits (234), Expect = 2e-19
Identities = 89/329 (27%), Positives = 143/329 (43%), Gaps = 72/329 (21%)
Query: 312 DDQKIVSGLRDNTIKIWDKNT-LECKRILTGHTGSVLCLQYDE-------RVIITGSSDS 363
D +K+ SG ++ I +WD +T + R L GH+ + L ++ R + + S D
Sbjct: 167 DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226
Query: 364 TVRVWDVNTGEMLNTLIHHCEAVLHLRF-NNGMMVTCSKDRSIAVW-------------- 408
+VR+WD G L H ++V LR+ +G++ + S+DR+I VW
Sbjct: 227 SVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGH 286
Query: 409 -----DMASPTDITLRR-VLVGHRAAVNVVDFD---------------------DKYIVS 441
MA TD LR A+VN D + +VS
Sbjct: 287 GHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVS 346
Query: 442 ASGDRTIKVWNTSTCEFVRT-LNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGAC 498
S D T+ +W+ + + T + GH+ I + + R+V S S D +I+LWD G
Sbjct: 347 GSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKY 406
Query: 499 LRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVA---ALDPRAPAGTLCLRTLVE 553
L L GH V I + D++ +VSG+ D +KVWD+ A A+D L
Sbjct: 407 LASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD------------LPG 454
Query: 554 HSGRVFRLQF--DEFQIVSSSHDDTILIW 580
H+ V+ + + D ++ S D + IW
Sbjct: 455 HADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 91.7 bits (226), Expect = 2e-18
Identities = 86/326 (26%), Positives = 136/326 (41%), Gaps = 72/326 (22%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 373
+ SG D T++ WD +T GH VL + + D R + +G + + +WD +TG
Sbjct: 129 LASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTG 188
Query: 374 EML-NTLIHHCEAV-------LHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGH 425
+ + TL H + + LH + + SKD S+ +WD T R+L GH
Sbjct: 189 KQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD---TTAGRCERILTGH 245
Query: 426 RAAVNVVDF-DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACL------------ 472
+V + + D + SAS DRTIKVW RTL GH + +
Sbjct: 246 TQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGA 305
Query: 473 ------------------QYRDRL--------------VVSGSSDNTIRLWD-IECGACL 499
+ ++R +VSGS D T+ LW E L
Sbjct: 306 FEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPL 365
Query: 500 RVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGR 557
+ GH+ L+ + F D++ + S ++D IK+WD G L +L H
Sbjct: 366 TRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD--------GRTGKY-LASLRGHVAA 416
Query: 558 VFRLQF--DEFQIVSSSHDDTILIWD 581
V+++ + D +VS S D T+ +WD
Sbjct: 417 VYQIAWSADSRLLVSGSSDSTLKVWD 442
Score = 89.4 bits (220), Expect = 9e-18
Identities = 72/272 (26%), Positives = 131/272 (48%), Gaps = 27/272 (9%)
Query: 335 CKRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRF- 391
C L GH+ +V+ + + + + +GS D+TVR WD++T T H VL + +
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
Query: 392 -NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDD-------KYIVSAS 443
+ + + K+ I +WD + T + R L GH + + ++ +Y+ S+S
Sbjct: 166 PDGRKLASGCKNGQILLWDPS--TGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSS 223
Query: 444 GDRTIKVWNTSTCEFVRTLNGHKRGIACLQY-RDRLVVSGSSDNTIRLWDIECGACLRVL 502
D ++++W+T+ R L GH + + CL++ D L+ S S D TI++W G R L
Sbjct: 224 KDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTL 283
Query: 503 EGHEELVRCIRFD-NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLC-LRTLVEHSGRVFR 560
+GH V + + + +GA++ A+++P+ G+L L+ + R
Sbjct: 284 QGHGHWVNTMALSTDYALRTGAFE------PAEASVNPQDLQGSLQELKERALSRYNLVR 337
Query: 561 LQFDEFQIVSSSHDDTILIWDFLNDPAAQAEP 592
Q E ++VS S D T+ +W PA +P
Sbjct: 338 GQGPE-RLVSGSDDFTLFLW----SPAEDKKP 364
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 109 bits (272), Expect = 8e-24
Identities = 71/249 (28%), Positives = 115/249 (46%), Gaps = 18/249 (7%)
Query: 286 WRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGS 345
WR G H+ CR D S D T+++WD +C R+L GH S
Sbjct: 57 WRLGGHTGPVKFCRFSP---------DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS 107
Query: 346 VLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNN--GMMVTCSK 401
V + + D R + +G D V +WDV +G+ML L+ H +++ F+ + T S
Sbjct: 108 VETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW 167
Query: 402 DRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFD-DKYIVSASGDRTIKVWNTSTCEFVR 460
D ++ +WD+ T + L GH A ++ + + + S S D+TI +W +T +
Sbjct: 168 DSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLI 227
Query: 461 TLNGHKRGIACLQYR-DRL-VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DN 516
L GH + + + D L + S +++WD G CL L+G ++ F D
Sbjct: 228 QLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDG 287
Query: 517 KRIVSGAYD 525
K +VSGA D
Sbjct: 288 KILVSGAAD 296
Score = 100 bits (250), Expect = 3e-21
Identities = 70/233 (30%), Positives = 112/233 (48%), Gaps = 15/233 (6%)
Query: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 369
D Q +++G D + W+ + + L GHTG V ++ D + + S D TVR+WD
Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Query: 370 VNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRA 427
V + L L H +V + F ++ + + D+ + +WD+ S + R+LVGHR
Sbjct: 92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG---QMLRLLVGHRD 148
Query: 428 AVNVVDFDD--KYIVSASGDRTIKVWN---TSTCEFVRTLNGHKRGIACLQY-RDRLVVS 481
++ DF + + S D T+ +W+ + + L GH I+CL Y L+ S
Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLAS 208
Query: 482 GSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 532
GS D TI +W + L L+GH V+ I F D + S Y +KVWD
Sbjct: 209 GSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261
Score = 91.7 bits (226), Expect = 2e-18
Identities = 63/242 (26%), Positives = 115/242 (47%), Gaps = 24/242 (9%)
Query: 352 DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWD 409
D ++++TGS D V W+ +G++L L H V RF + + + S D ++ +WD
Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Query: 410 MASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKR 467
+A + RVL GH+ +V V F D + + S D+ + +W+ + + +R L GH+
Sbjct: 92 VARAKCL---RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRD 148
Query: 468 GIACLQYRDRL--VVSGSSDNTIRLWDIEC---GACLRVLEGHEELVRCIRFD-NKRIVS 521
I + + + +GS D+T+ +WD+ + LEGH + C+ + + + S
Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLAS 208
Query: 522 GAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILI 579
G++D I +W P + L L H V + F DE + S+ + + +
Sbjct: 209 GSWDKTIHIW---------KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259
Query: 580 WD 581
WD
Sbjct: 260 WD 261
Score = 75.5 bits (184), Expect = 1e-13
Identities = 52/179 (29%), Positives = 84/179 (46%), Gaps = 19/179 (10%)
Query: 413 PTDITLRRVLV--GHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRG 468
P + +RRV H VN F D + +++ S D + W T + + + L GH
Sbjct: 6 PATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGP 65
Query: 469 IACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAY 524
+ ++ L S S D T+RLWD+ CLRVL+GH+ V + F D++++ SG +
Sbjct: 66 VKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGW 125
Query: 525 DGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIWD 581
D ++ +WD+ + LR LV H + F + + S D T+ IWD
Sbjct: 126 DKRVMLWDVQSG---------QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 106 bits (264), Expect = 7e-23
Identities = 72/251 (28%), Positives = 122/251 (48%), Gaps = 14/251 (5%)
Query: 293 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQ 350
LQ I + + + + + +G D + +W N C LTGHT V + L
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
Query: 351 YDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVW 408
E +I+ GS ++RVWD+ ++L TL+ H + L F+ + + S+D +I +W
Sbjct: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
Query: 409 DMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHK 466
D+ + R GH AV + F D K++ SA+ D T+K+W+ + + + GH
Sbjct: 133 DIRRKGCVFRYR---GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189
Query: 467 RGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSG 522
+ +++ + L+ SGSSD TIR WD+E + +EG VR + F D + SG
Sbjct: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249
Query: 523 AYDG-KIKVWD 532
D ++ W+
Sbjct: 250 CQDSLRVYGWE 260
Score = 99.0 bits (245), Expect = 1e-20
Identities = 69/221 (31%), Positives = 103/221 (46%), Gaps = 23/221 (10%)
Query: 372 TGEMLNTLIHHCEAVLHL---RFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 428
T L ++ H V L + + ++ T D + +W + P I L GH +
Sbjct: 9 TAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMS---LTGHTSP 65
Query: 429 VNVVDFD--DKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSS 484
V V + ++ IV+ S +I+VW+ + +RTL GHK I L + V SGS
Sbjct: 66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQ 125
Query: 485 DNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAALDPRAP 542
D I+LWDI C+ GH + VRC+RF D K + S A D +K+WDL A
Sbjct: 126 DTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG------ 179
Query: 543 AGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 581
+ H+G V ++F +E+ + S S D TI WD
Sbjct: 180 ---KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
>gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens]
Length = 454
Score = 103 bits (257), Expect = 5e-22
Identities = 114/463 (24%), Positives = 184/463 (39%), Gaps = 120/463 (25%)
Query: 139 KYFEQWSESDQVEFV-----------EHLISQMCHYQHGHINSYLKPMLQRDFITALPAR 187
K FE W ++ V F+ +HLIS Q H+++ L+ +L+RDF+ LP
Sbjct: 4 KDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLE 63
Query: 188 GLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRG 247
++ +L +LD ++L LV K+W +V S +W+ + G
Sbjct: 64 ----LSFYLLKWLDPQTLLTCCLVSKQWNKVIS-------------ACTEVWQTACKNLG 106
Query: 248 WGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVY 307
W D + ++ +Y K I ++ +E H ETS
Sbjct: 107 W--------QIDDSVQDALHWKKVYLKAILRMKQLED------------HEAFETSS--- 143
Query: 308 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRV 367
L GH+ V L Y + ++ TGS D + ++
Sbjct: 144 -------------------------------LIGHSARVYALYYKDGLLCTGSDDLSAKL 172
Query: 368 WDVNTGEMLNTL-IHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHR 426
WDV+TG+ + + H C AV +F+ +VT S D ++A W+ +S R GH
Sbjct: 173 WDVSTGQCVYGIQTHTCAAV---KFDEQKLVTGSFDNTVACWEWSSGARTQHFR---GHT 226
Query: 427 AAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI-----------ACLQ 473
AV VD++D+ +VS S D T+KVW S + TL GH + + L
Sbjct: 227 GAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLH 286
Query: 474 YRDRLVVSGSSDNTIRLW----DIECGACLRVLEGHEELVRCIR----FDNKRIVS---- 521
++ + I++W +I C CL+ L E+ C++ FD K IV
Sbjct: 287 SPGDYILLSADKYEIKIWPIGREINC-KCLKTLSVSEDRSICLQPRLHFDGKYIVCSSAL 345
Query: 522 GAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD 564
G Y +D++ + A L G +F L FD
Sbjct: 346 GLYQWDFASYDILRVIKTPEIANLALL-----GFGDIFALLFD 383
Score = 65.1 bits (157), Expect = 2e-10
Identities = 36/122 (29%), Positives = 64/122 (52%), Gaps = 13/122 (10%)
Query: 461 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV 520
+L GH + L Y+D L+ +GS D + +LWD+ G C+ ++ H ++FD +++V
Sbjct: 143 SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTH--TCAAVKFDEQKLV 200
Query: 521 SGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF-DEFQI-VSSSHDDTIL 578
+G++D + W+ + + G H+G VF + + DE I VS S D T+
Sbjct: 201 TGSFDNTVACWEWSSGARTQHFRG---------HTGAVFSVDYNDELDILVSGSADFTVK 251
Query: 579 IW 580
+W
Sbjct: 252 VW 253
Score = 32.3 bits (72), Expect = 1.3
Identities = 20/88 (22%), Positives = 41/88 (46%), Gaps = 11/88 (12%)
Query: 502 LEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL 561
L GH V + + + + +G+ D K+WD+ C+ + H+ +
Sbjct: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQ---------CVYGIQTHTCAA--V 192
Query: 562 QFDEFQIVSSSHDDTILIWDFLNDPAAQ 589
+FDE ++V+ S D+T+ W++ + Q
Sbjct: 193 KFDEQKLVTGSFDNTVACWEWSSGARTQ 220
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 102 bits (255), Expect = 8e-22
Identities = 71/242 (29%), Positives = 115/242 (47%), Gaps = 18/242 (7%)
Query: 310 QYDDQKIVSGLRDNTI-KIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVR 366
Q D ++ D+ + +I D+ T +IL GH+G V + D +++ S D TVR
Sbjct: 509 QASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVR 568
Query: 367 VWDVNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVW--DMASPTDITLRRVL 422
+W + T L H V +F+ V+ DR +W D P R+
Sbjct: 569 LWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPL-----RIF 623
Query: 423 VGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQY--RDRL 478
GH A VN F + Y+ + S DRT+++W+ VR GHK I L + R
Sbjct: 624 AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRF 683
Query: 479 VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAA 536
+ +G++D + LWDI G + L+GH + V +RF D + + SG+ D +++WD + A
Sbjct: 684 LATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKA 743
Query: 537 LD 538
+
Sbjct: 744 FE 745
Score = 99.0 bits (245), Expect = 1e-20
Identities = 86/350 (24%), Positives = 149/350 (42%), Gaps = 45/350 (12%)
Query: 254 KNKPPDGNAPPNSFYRALYPKI--------IQDIETIESNWRCGRHSLQRI--HCRSETS 303
K+K D NAPP + R P++ I +++ R G L I +
Sbjct: 413 KSKKQDPNAPPQN--RIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAY 470
Query: 304 KGVYCLQYDDQK--IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSS 361
+G+ + D I G D+T+++W + + + D +I S
Sbjct: 471 QGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQAS---------DLSLIDKESD 521
Query: 362 DSTVRVWDVNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLR 419
D R+ D T L L H V F+ +++ S+D ++ +W + + T +
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
Query: 420 RVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR-- 475
+ GH V F Y VS DR ++W T + +R GH + C ++
Sbjct: 582 K---GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN 638
Query: 476 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 533
V +GS+D T+RLWD+ G C+R+ GH+ + + F + + + +GA DG++ +WD+
Sbjct: 639 SNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI 698
Query: 534 VAALDPRAPAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 581
L + L H+ V L+F D + S S D+T+ +WD
Sbjct: 699 ---------GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 101 bits (251), Expect = 2e-21
Identities = 79/279 (28%), Positives = 134/279 (48%), Gaps = 16/279 (5%)
Query: 313 DQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDV 370
+Q V+G D TIKIWD + + K LTGH +V + R + + D V+ WD+
Sbjct: 216 NQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL 275
Query: 371 NTGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 428
+++ H AV L L ++VTCS+D + +WD+ + + L GH A
Sbjct: 276 EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASV---HTLSGHTNA 332
Query: 429 VNVV--DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSS 484
V V + I++ S D TI++W+ + TL HK+ + L R SGS
Sbjct: 333 VATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSP 392
Query: 485 DNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRI-VSGAYDGKIKVWDLVAALDPRAPA 543
DN I+ W G+ ++ L GH ++ + ++ + VSGA +G + +WD + +
Sbjct: 393 DN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVH 451
Query: 544 GTLCLRTLVEHSGRVFRLQFD--EFQIVSSSHDDTILIW 580
+ +L SG +F FD E +++++ D TI ++
Sbjct: 452 AAVQPGSLDSESG-IFACAFDQSESRLLTAEADKTIKVY 489
Score = 100 bits (248), Expect = 5e-21
Identities = 71/257 (27%), Positives = 130/257 (50%), Gaps = 24/257 (9%)
Query: 337 RILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFN 392
R+++GH G V C+ + + +TGS+D T+++WD+ +G++ +L H V + +
Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
Query: 393 NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKV 450
+ + +C +D+ + WD+ I R GH +AV +D +V+ S D T ++
Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVI---RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
Query: 451 WNTSTCEFVRTLNGHKRGIACL--QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL 508
W+ T V TL+GH +A + Q + +++GS D TIRLWD+ G L H++
Sbjct: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
Query: 509 VRCIRFDNKR--IVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD-E 565
VR + + SG+ D IK W + P G+ ++ L H+ + L + +
Sbjct: 375 VRAVVLHPRHYTFASGSPD-NIKQW--------KFPDGSF-IQNLSGHNAIINTLTVNSD 424
Query: 566 FQIVSSSHDDTILIWDF 582
+VS + + T+ +WD+
Sbjct: 425 GVLVSGADNGTMHLWDW 441
Score = 66.6 bits (161), Expect = 6e-11
Identities = 51/175 (29%), Positives = 84/175 (48%), Gaps = 19/175 (10%)
Query: 418 LRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWNTSTCEFVRTLNGH---KRGIACL 472
L RV+ GH V + + +++ V+ S DRTIK+W+ ++ + +L GH RG+ +
Sbjct: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI-V 254
Query: 473 QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 530
R + S D ++ WD+E +R GH V + +V+ + D ++
Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
Query: 531 WDLVAALDPRAPAGTLCLRTLVEHSGRV--FRLQFDEFQIVSSSHDDTILIWDFL 583
WD+ R A + TL H+ V R Q E QI++ SHD TI +WD +
Sbjct: 315 WDV------RTKAS---VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360
Score = 45.4 bits (106), Expect = 1e-04
Identities = 48/194 (24%), Positives = 85/194 (43%), Gaps = 26/194 (13%)
Query: 281 TIESNWRCGRHSLQRI---------HCRSETSKGVYCL--QYDDQKIVSGLRDNTIKIWD 329
TI+ C R S RI H S + V + Q + +I++G D TI++WD
Sbjct: 299 TIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358
Query: 330 KNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVL 387
+ + LT H SV + R +GS D+ ++ W G + L H +
Sbjct: 359 LVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIIN 417
Query: 388 HLRFN-NGMMVTCSKDRSIAVWDMASPTDITLRRV-------LVGHRAAVNVVDFD--DK 437
L N +G++V+ + + ++ +WD T +RV + + + FD +
Sbjct: 418 TLTVNSDGVLVSGADNGTMHLWDWR--TGYNFQRVHAAVQPGSLDSESGIFACAFDQSES 475
Query: 438 YIVSASGDRTIKVW 451
+++A D+TIKV+
Sbjct: 476 RLLTAEADKTIKVY 489
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 99.4 bits (246), Expect = 9e-21
Identities = 73/280 (26%), Positives = 120/280 (42%), Gaps = 30/280 (10%)
Query: 279 IETIESNWRCGRHSLQRIHCRSE------TSKGVYCLQY--DDQKIVSGLRDNTIKIWDK 330
I + N G L HC E ++K V L + D + G D +IW +
Sbjct: 205 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTE 264
Query: 331 NTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 388
N L H G + L+++++ +++ D T +WD +TGE H L
Sbjct: 265 NG-NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323
Query: 389 LRFNNGM-MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGD 445
+ + N M +CS D I V + + + GH VN + +D + S S D
Sbjct: 324 VDWQNNMTFASCSTDMCIHVCRLGCDHPV---KTFQGHTNEVNAIKWDPSGMLLASCSDD 380
Query: 446 RTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-----------LVVSGSSDNTIRLWDIE 494
T+K+W+ V L H + I +++ ++ S S D+T+RLWD+E
Sbjct: 381 MTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVE 440
Query: 495 CGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 532
G C L H+E V + F D K + SG++D + +W+
Sbjct: 441 QGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480
Score = 63.9 bits (154), Expect = 4e-10
Identities = 58/278 (20%), Positives = 115/278 (41%), Gaps = 47/278 (16%)
Query: 338 ILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVN---TGEMLNTLIHHC--------- 383
+L GH V ++ ++ +GS DST R+W++N G ++ HC
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233
Query: 384 --EAVLHLRFNNG--MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 437
+ V L +N+ ++ S D +W + L L H+ + + ++ K
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW----TENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 438 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLV-VSGSSDNTIRLWDIECG 496
Y++SA D+T +W+ T E + H + +++ + S S+D I + + C
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
Query: 497 ACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEH 554
++ +GH V I++D + S + D +K+W + C+ L H
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM---------KQDACVHDLQAH 400
Query: 555 SGRVFRLQF-----------DEFQIVSSSHDDTILIWD 581
S ++ +++ + S+S D T+ +WD
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438
Score = 59.7 bits (143), Expect = 8e-09
Identities = 49/235 (20%), Positives = 99/235 (42%), Gaps = 20/235 (8%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITG-SSDSTVRVWDVNTGE 374
++S D T IWD +T E K+ H+ L + + + S+D + V +
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDH 350
Query: 375 MLNTLIHHCEAVLHLRFN-NGMMV-TCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 432
+ T H V ++++ +GM++ +CS D ++ +W M + L H + +
Sbjct: 351 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACV---HDLQAHSKEIYTI 407
Query: 433 DFDDK-----------YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLV 479
+ + SAS D T+++W+ TL H+ + + + + +
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 480 VSGSSDNTIRLWDIECGACLRVLEGHEELVR-CIRFDNKRIVSGAYDGKIKVWDL 533
SGS D + +W+ + G+ + +G + C ++ + A DG + V DL
Sbjct: 468 ASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 99.4 bits (246), Expect = 9e-21
Identities = 73/280 (26%), Positives = 120/280 (42%), Gaps = 30/280 (10%)
Query: 279 IETIESNWRCGRHSLQRIHCRSE------TSKGVYCLQY--DDQKIVSGLRDNTIKIWDK 330
I + N G L HC E ++K V L + D + G D +IW +
Sbjct: 205 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTE 264
Query: 331 NTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 388
N L H G + L+++++ +++ D T +WD +TGE H L
Sbjct: 265 NG-NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323
Query: 389 LRFNNGM-MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGD 445
+ + N M +CS D I V + + + GH VN + +D + S S D
Sbjct: 324 VDWQNNMTFASCSTDMCIHVCRLGCDHPV---KTFQGHTNEVNAIKWDPSGMLLASCSDD 380
Query: 446 RTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-----------LVVSGSSDNTIRLWDIE 494
T+K+W+ V L H + I +++ ++ S S D+T+RLWD+E
Sbjct: 381 MTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVE 440
Query: 495 CGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 532
G C L H+E V + F D K + SG++D + +W+
Sbjct: 441 QGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480
Score = 63.9 bits (154), Expect = 4e-10
Identities = 58/278 (20%), Positives = 115/278 (41%), Gaps = 47/278 (16%)
Query: 338 ILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVN---TGEMLNTLIHHC--------- 383
+L GH V ++ ++ +GS DST R+W++N G ++ HC
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233
Query: 384 --EAVLHLRFNNG--MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 437
+ V L +N+ ++ S D +W + L L H+ + + ++ K
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW----TENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 438 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLV-VSGSSDNTIRLWDIECG 496
Y++SA D+T +W+ T E + H + +++ + S S+D I + + C
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
Query: 497 ACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEH 554
++ +GH V I++D + S + D +K+W + C+ L H
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM---------KQDACVHDLQAH 400
Query: 555 SGRVFRLQF-----------DEFQIVSSSHDDTILIWD 581
S ++ +++ + S+S D T+ +WD
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438
Score = 59.7 bits (143), Expect = 8e-09
Identities = 49/235 (20%), Positives = 99/235 (42%), Gaps = 20/235 (8%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITG-SSDSTVRVWDVNTGE 374
++S D T IWD +T E K+ H+ L + + + S+D + V +
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDH 350
Query: 375 MLNTLIHHCEAVLHLRFN-NGMMV-TCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 432
+ T H V ++++ +GM++ +CS D ++ +W M + L H + +
Sbjct: 351 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACV---HDLQAHSKEIYTI 407
Query: 433 DFDDK-----------YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLV 479
+ + SAS D T+++W+ TL H+ + + + + +
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 480 VSGSSDNTIRLWDIECGACLRVLEGHEELVR-CIRFDNKRIVSGAYDGKIKVWDL 533
SGS D + +W+ + G+ + +G + C ++ + A DG + V DL
Sbjct: 468 ASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 99.4 bits (246), Expect = 9e-21
Identities = 73/280 (26%), Positives = 120/280 (42%), Gaps = 30/280 (10%)
Query: 279 IETIESNWRCGRHSLQRIHCRSE------TSKGVYCLQY--DDQKIVSGLRDNTIKIWDK 330
I + N G L HC E ++K V L + D + G D +IW +
Sbjct: 205 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTE 264
Query: 331 NTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 388
N L H G + L+++++ +++ D T +WD +TGE H L
Sbjct: 265 NG-NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323
Query: 389 LRFNNGM-MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGD 445
+ + N M +CS D I V + + + GH VN + +D + S S D
Sbjct: 324 VDWQNNMTFASCSTDMCIHVCRLGCDHPV---KTFQGHTNEVNAIKWDPSGMLLASCSDD 380
Query: 446 RTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-----------LVVSGSSDNTIRLWDIE 494
T+K+W+ V L H + I +++ ++ S S D+T+RLWD+E
Sbjct: 381 MTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVE 440
Query: 495 CGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 532
G C L H+E V + F D K + SG++D + +W+
Sbjct: 441 QGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480
Score = 63.9 bits (154), Expect = 4e-10
Identities = 58/278 (20%), Positives = 115/278 (41%), Gaps = 47/278 (16%)
Query: 338 ILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVN---TGEMLNTLIHHC--------- 383
+L GH V ++ ++ +GS DST R+W++N G ++ HC
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233
Query: 384 --EAVLHLRFNNG--MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 437
+ V L +N+ ++ S D +W + L L H+ + + ++ K
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW----TENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 438 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLV-VSGSSDNTIRLWDIECG 496
Y++SA D+T +W+ T E + H + +++ + S S+D I + + C
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
Query: 497 ACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEH 554
++ +GH V I++D + S + D +K+W + C+ L H
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM---------KQDACVHDLQAH 400
Query: 555 SGRVFRLQF-----------DEFQIVSSSHDDTILIWD 581
S ++ +++ + S+S D T+ +WD
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438
Score = 59.7 bits (143), Expect = 8e-09
Identities = 49/235 (20%), Positives = 99/235 (42%), Gaps = 20/235 (8%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITG-SSDSTVRVWDVNTGE 374
++S D T IWD +T E K+ H+ L + + + S+D + V +
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDH 350
Query: 375 MLNTLIHHCEAVLHLRFN-NGMMV-TCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 432
+ T H V ++++ +GM++ +CS D ++ +W M + L H + +
Sbjct: 351 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACV---HDLQAHSKEIYTI 407
Query: 433 DFDDK-----------YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLV 479
+ + SAS D T+++W+ TL H+ + + + + +
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 480 VSGSSDNTIRLWDIECGACLRVLEGHEELVR-CIRFDNKRIVSGAYDGKIKVWDL 533
SGS D + +W+ + G+ + +G + C ++ + A DG + V DL
Sbjct: 468 ASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 99.0 bits (245), Expect = 1e-20
Identities = 71/280 (25%), Positives = 124/280 (44%), Gaps = 30/280 (10%)
Query: 279 IETIESNWRCGRHSLQRIHCRSE------TSKGVYCLQYDDQK--IVSGLRDNTIKIWDK 330
I + N G L HC E ++K V L ++ + + +G D +IW K
Sbjct: 195 IWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTK 254
Query: 331 NTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 388
+ L H G + L+++++ I++ D T +WD +TGE H L
Sbjct: 255 DG-NLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 313
Query: 389 LRF-NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDD--KYIVSASGD 445
+ + +N +CS D I V + I + GH VN + +D + S S D
Sbjct: 314 VDWQSNNTFASCSTDMCIHVCKLGQDRPI---KTFQGHTNEVNAIKWDPTGNLLASCSDD 370
Query: 446 RTIKVWNTSTCEFVRTLNGHKRGIACLQYR-----------DRLVVSGSSDNTIRLWDIE 494
T+K+W+ V L H + I +++ + ++ S S D+T+RLWD++
Sbjct: 371 MTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVD 430
Query: 495 CGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 532
G C+ L H+E V + F D + + SG++D + +W+
Sbjct: 431 RGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470
Score = 65.5 bits (158), Expect = 1e-10
Identities = 64/320 (20%), Positives = 125/320 (39%), Gaps = 89/320 (27%)
Query: 338 ILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDV---NTGEMLNTLIHHC--------- 383
+L GH V ++ ++ +GS DST R+W++ +T ++ HC
Sbjct: 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223
Query: 384 --EAVLHLRFNN--GMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 437
+ V L +N+ ++ T S D +W D L L H+ + + ++ K
Sbjct: 224 SNKDVTSLDWNSEGTLLATGSYDGFARIW----TKDGNLASTLGQHKGPIFALKWNKKGN 279
Query: 438 YIVSASGDRTIKVWNTSTCEF--------------------------------------- 458
+I+SA D+T +W+ T E
Sbjct: 280 FILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQD 339
Query: 459 --VRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF 514
++T GH + +++ L+ S S D T+++W ++ C+ L+ H + + I++
Sbjct: 340 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKW 399
Query: 515 D-----------NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF 563
N + S ++D +++WD+ +C+ TL +H V+ + F
Sbjct: 400 SPTGPGTNNPNANLMLASASFDSTVRLWDVDRG---------ICIHTLTKHQEPVYSVAF 450
Query: 564 --DEFQIVSSSHDDTILIWD 581
D + S S D + IW+
Sbjct: 451 SPDGRYLASGSFDKCVHIWN 470
Score = 63.9 bits (154), Expect = 4e-10
Identities = 50/235 (21%), Positives = 97/235 (41%), Gaps = 20/235 (8%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER-VIITGSSDSTVRVWDVNTGE 374
I+S D T IWD +T E K+ H+ L + + + S+D + V +
Sbjct: 281 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDR 340
Query: 375 MLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 432
+ T H V ++++ ++ +CS D ++ +W M + L H + +
Sbjct: 341 PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCV---HDLQAHNKEIYTI 397
Query: 433 DFD-----------DKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLV 479
+ + + SAS D T+++W+ + TL H+ + + + R +
Sbjct: 398 KWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYL 457
Query: 480 VSGSSDNTIRLWDIECGACLRVLEGHEELVR-CIRFDNKRIVSGAYDGKIKVWDL 533
SGS D + +W+ + GA + G + C ++ + A DG + V DL
Sbjct: 458 ASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDL 512
Score = 42.4 bits (98), Expect = 0.001
Identities = 43/155 (27%), Positives = 66/155 (42%), Gaps = 38/155 (24%)
Query: 462 LNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELV--RCIRF--- 514
L GH+ + + L+ SGS D+T R+W++ + G +LV CIR
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENS----TSGSTQLVLRHCIREGGQ 220
Query: 515 ---DNKRIVS------------GAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVF 559
NK + S G+YDG ++W G L TL +H G +F
Sbjct: 221 DVPSNKDVTSLDWNSEGTLLATGSYDGFARIW---------TKDGNLA-STLGQHKGPIF 270
Query: 560 RLQFDEFQ--IVSSSHDDTILIWDFLNDPAAQAEP 592
L++++ I+S+ D T +IWD A Q P
Sbjct: 271 ALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFP 305
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 95.9 bits (237), Expect = 1e-19
Identities = 70/293 (23%), Positives = 138/293 (47%), Gaps = 28/293 (9%)
Query: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVN 371
D+ ++S D+ IKIW+++TL+C R +T +R ++ G+ ++++D+
Sbjct: 426 DNIAVLSAAADS-IKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLA 484
Query: 372 TGEMLNTLIHHCEAVLHLRFNNGM--MVTCSKDRSIAVWD--MASPTDITLRRVLVGHRA 427
+G +L T+ H A+ + + VT D+S+ WD + + T +R+ V
Sbjct: 485 SGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTR 544
Query: 428 AVNVVDF--------DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQ--YRDR 477
+ + + + K + + D T+K++ T +F +L GHK + C+ +
Sbjct: 545 TLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGA 604
Query: 478 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLVA 535
L+ +GS+D +++W ++ G C + L H++ V ++F K + D KIK WD
Sbjct: 605 LIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADK 664
Query: 536 ALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF--QIVSSSHDDTILIWDFLNDP 586
++TL H ++ L +VSSSHD ++ +W+ +P
Sbjct: 665 FEH---------IQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREP 708
Score = 72.8 bits (177), Expect = 9e-13
Identities = 48/159 (30%), Positives = 86/159 (54%), Gaps = 11/159 (6%)
Query: 301 ETSKGVYCLQYD-DQKIVS-GLRDNTIKIWDKNTLECKRILTGHTGSVLCLQ--YDERVI 356
+ + V C+ Y +QK+++ L D T+KI+ +TL+ L GH V+C+ +D +I
Sbjct: 547 QLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALI 606
Query: 357 ITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPT 414
TGS+D V++W ++ G+ +L H ++V++L+F + + T KD I WD
Sbjct: 607 ATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFE 666
Query: 415 DITLRRVLVGHRAAV--NVVDFDDKYIVSASGDRTIKVW 451
I + L GH + V Y+VS+S D+++++W
Sbjct: 667 HI---QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
Score = 72.4 bits (176), Expect = 1e-12
Identities = 57/190 (30%), Positives = 94/190 (49%), Gaps = 16/190 (8%)
Query: 327 IWDKNTLECKRILTGHTGSVLCL--QYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCE 384
IWD E IL G V CL D + G D ++R++ + +GE T H
Sbjct: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
Query: 385 AVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIV 440
A+ L+++ G + + SKD I VWD+ + + + L GH+ A+ F + +V
Sbjct: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYR---LKGHKDAITQALFLREKNLLV 165
Query: 441 SASGDRTIKVWNTSTCEFVRTLNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDIECGA 497
++ D +K W+ T +T+ GH+ G+ L RL ++G+SD+ +R+WDI A
Sbjct: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRL-ITGASDSELRVWDI---A 221
Query: 498 CLRVLEGHEE 507
L+ +E EE
Sbjct: 222 YLQEIEDPEE 231
Score = 67.0 bits (162), Expect = 5e-11
Identities = 55/204 (26%), Positives = 96/204 (47%), Gaps = 24/204 (11%)
Query: 309 LQYDDQKIVSGLRDNTIKIW------DKNTLECKRILTGHTGS------VLCLQY--DER 354
L D + V+G D ++K W D+N+ + KR+ T + VLC+ Y +++
Sbjct: 504 LSPDQRGFVTGGADKSVKFWDFELVKDENSTQ-KRLSVKQTRTLQLDEDVLCVSYSPNQK 562
Query: 355 VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWDMAS 412
++ D TV+++ V+T + +L H V + + + ++ T S DR++ +W +
Sbjct: 563 LLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDF 622
Query: 413 PTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIA 470
+ L H +V + F K +A D IK W+ E ++TL GH + I
Sbjct: 623 G---DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIW 679
Query: 471 CLQYRDR--LVVSGSSDNTIRLWD 492
CL VVS S D ++RLW+
Sbjct: 680 CLAVSPSGDYVVSSSHDKSLRLWE 703
Score = 63.2 bits (152), Expect = 7e-10
Identities = 49/178 (27%), Positives = 89/178 (50%), Gaps = 13/178 (7%)
Query: 365 VRVWDVNTGEMLNTLIHHCEAVLHLRFN-NGMMVTCS-KDRSIAVWDMASPT-DITLRRV 421
V +WD+ GE + L + V L + +G+ + +D SI ++ + S ++T
Sbjct: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN-- 104
Query: 422 LVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIA-CLQYRDR- 477
GH+AA+ + +D + S S D I VW+ + L GHK I L R++
Sbjct: 105 --GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162
Query: 478 LVVSGSSDNTIRLWDIECGACLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWDL 533
L+V+ D ++ WD++ C + + GH V + + KR+++GA D +++VWD+
Sbjct: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
Score = 59.3 bits (142), Expect = 1e-08
Identities = 40/151 (26%), Positives = 72/151 (47%), Gaps = 9/151 (5%)
Query: 308 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE--RVIITGSSDSTV 365
C D + G D +I+I+ + E GH ++ L+YD+ + +GS D+ +
Sbjct: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131
Query: 366 RVWDVNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLV 423
VWDV L L H +A+ F ++VT KD + WD+ + + +V
Sbjct: 132 IVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCF---KTMV 188
Query: 424 GHRAAV--NVVDFDDKYIVSASGDRTIKVWN 452
GHR V V+ ++K +++ + D ++VW+
Sbjct: 189 GHRTEVWGLVLLSEEKRLITGASDSELRVWD 219
Score = 48.9 bits (115), Expect = 1e-05
Identities = 23/57 (40%), Positives = 36/57 (63%), Gaps = 2/57 (3%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQYDERVIITGSSDSTVRVWDV 370
+V+ +D +K WD +T C + + GH V L L +E+ +ITG+SDS +RVWD+
Sbjct: 164 LVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
Score = 39.3 bits (90), Expect = 0.011
Identities = 25/89 (28%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 450 VWNTSTCEFVRTLNGHKRGIACL-QYRDRLVVS-GSSDNTIRLWDIECGACLRVLEGHEE 507
+W+ E + L G K+ + CL D L ++ G D +IR++ + G GH+
Sbjct: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
Query: 508 LVRCIRFDNK--RIVSGAYDGKIKVWDLV 534
+ +++D R+ SG+ D I VWD++
Sbjct: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVI 137
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 95.5 bits (236), Expect = 1e-19
Identities = 65/251 (25%), Positives = 122/251 (48%), Gaps = 16/251 (6%)
Query: 294 QRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE 353
+++ RS+ K V L + +++ L + ++ +W+ T + V ++
Sbjct: 9 RKLTARSDRVKSVD-LHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67
Query: 354 RV--IITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWD 409
R ++TG+ D +RV++ NT E ++ H + + + + ++T S D I +WD
Sbjct: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127
Query: 410 MASPTDITLRRVLVGHRAAVNVVDF---DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHK 466
+ +V GH V + D+ SAS DRTIKVW + TL GH+
Sbjct: 128 WDKKWSCS--QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHE 185
Query: 467 RGIACLQYRD----RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IV 520
+G+ C+ Y ++SG+ D +++WD + C++ LEGH + V C F + I+
Sbjct: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIII 245
Query: 521 SGAYDGKIKVW 531
+G+ DG +++W
Sbjct: 246 TGSEDGTVRIW 256
Score = 68.2 bits (165), Expect = 2e-11
Identities = 48/194 (24%), Positives = 91/194 (46%), Gaps = 15/194 (7%)
Query: 291 HSLQRIHCRSETSKGVYCLQYDDQK--IVSGLRDNTIKIWD-KNTLECKRILTGHTGSVL 347
++L+R+H S + C+ + I++ D IK+WD C ++ GHT V+
Sbjct: 87 NTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVM 146
Query: 348 CLQY---DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG----MMVTCS 400
+ D + S D T++VW + + TL H + V + + +G +++ +
Sbjct: 147 QIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGA 206
Query: 401 KDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVWNTSTCEF 458
DR + +WD + T + + L GH V+ F + I++ S D T+++W++ST
Sbjct: 207 DDRLVKIWDYQNKTCV---QTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRL 263
Query: 459 VRTLNGHKRGIACL 472
TLN + C+
Sbjct: 264 ESTLNYGMERVWCV 277
Score = 59.7 bits (143), Expect = 8e-09
Identities = 69/268 (25%), Positives = 113/268 (42%), Gaps = 36/268 (13%)
Query: 333 LECKRILTGHTGSV--LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLR 390
L+ KR LT + V + L E ++ + +V VW+ T ++ T V +
Sbjct: 5 LDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAK 64
Query: 391 F--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLV--GHRAAVNVVDFD--DKYIVSASG 444
F +VT + D I V++ TL RV + H + + +I+++S
Sbjct: 65 FVARKNWVVTGADDMQIRVFNYN-----TLERVHMFEAHSDYIRCIAVHPTQPFILTSSD 119
Query: 445 DRTIKVWNTS---TCEFVRTLNGHKRGIACLQYRDR---LVVSGSSDNTIRLWDIECGAC 498
D IK+W+ +C V GH + + + S S D TI++W + +
Sbjct: 120 DMLIKLWDWDKKWSCSQV--FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSP 177
Query: 499 LRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEH 554
LEGHE+ V CI + D ++SGA D +K+WD C++TL H
Sbjct: 178 NFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDY---------QNKTCVQTLEGH 228
Query: 555 SGRVFRLQFDEFQ--IVSSSHDDTILIW 580
+ V F I++ S D T+ IW
Sbjct: 229 AQNVSCASFHPELPIIITGSEDGTVRIW 256
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 95.5 bits (236), Expect = 1e-19
Identities = 72/280 (25%), Positives = 120/280 (42%), Gaps = 30/280 (10%)
Query: 279 IETIESNWRCGRHSLQRIHCRSE------TSKGVYCLQYDDQK--IVSGLRDNTIKIWDK 330
I + N G L HC E ++K V L ++ + +G D +IW +
Sbjct: 207 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE 266
Query: 331 NTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 388
+ L H G + L+++ + I++ D T +WD +TGE H L
Sbjct: 267 DG-NLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 325
Query: 389 LRF-NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGD 445
+ + NN +CS D I V + + + GH VN + +D + S S D
Sbjct: 326 VDWQNNTTFASCSTDMCIHVCRLGCDRPV---KTFQGHTNEVNAIKWDPSGMLLASCSDD 382
Query: 446 RTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-----------LVVSGSSDNTIRLWDIE 494
T+K+W+ + L H + I +++ ++ S S D+T+RLWDIE
Sbjct: 383 MTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE 442
Query: 495 CGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 532
G C L H+E V + F D K + SG++D + +W+
Sbjct: 443 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 482
Score = 69.3 bits (168), Expect = 1e-11
Identities = 69/320 (21%), Positives = 125/320 (39%), Gaps = 89/320 (27%)
Query: 338 ILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVN---TGEMLNTLIHHC--------- 383
+L GH V ++ ++ +GS DST R+W++N G ++ HC
Sbjct: 176 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235
Query: 384 --EAVLHLRFN-NG-MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 437
+ V L +N NG ++ T S D +W D L L H+ + + ++ K
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIW----TEDGNLASTLGQHKGPIFALKWNRKGN 291
Query: 438 YIVSASGDRTIKVWNTSTCEF--------------------------------------- 458
YI+SA D+T +W+ T E
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 351
Query: 459 --VRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF 514
V+T GH + +++ L+ S S D T+++W ++ C+ L+ H + + I++
Sbjct: 352 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKW 411
Query: 515 -----------DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF 563
N + S ++D +++WD+ +C TL +H V+ + F
Sbjct: 412 SPTGPATSNPNSNIMLASASFDSTVRLWDIERG---------VCTHTLTKHQEPVYSVAF 462
Query: 564 --DEFQIVSSSHDDTILIWD 581
D + S S D + IW+
Sbjct: 463 SPDGKYLASGSFDKCVHIWN 482
Score = 59.3 bits (142), Expect = 1e-08
Identities = 51/235 (21%), Positives = 96/235 (40%), Gaps = 20/235 (8%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITG-SSDSTVRVWDVNTGE 374
I+S D T IWD +T E K+ H+ L + + S+D + V +
Sbjct: 293 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDR 352
Query: 375 MLNTLIHHCEAVLHLRFN-NGMMV-TCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 432
+ T H V ++++ +GM++ +CS D ++ +W M I L H + +
Sbjct: 353 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCI---HDLQAHNKEIYTI 409
Query: 433 DFDDK-----------YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLV 479
+ + SAS D T+++W+ TL H+ + + + + +
Sbjct: 410 KWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYL 469
Query: 480 VSGSSDNTIRLWDIECGACLRVLEGHEELVR-CIRFDNKRIVSGAYDGKIKVWDL 533
SGS D + +W+ + G + G + C ++ + A DG + V DL
Sbjct: 470 ASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 524
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 95.5 bits (236), Expect = 1e-19
Identities = 72/280 (25%), Positives = 120/280 (42%), Gaps = 30/280 (10%)
Query: 279 IETIESNWRCGRHSLQRIHCRSE------TSKGVYCLQYDDQK--IVSGLRDNTIKIWDK 330
I + N G L HC E ++K V L ++ + +G D +IW +
Sbjct: 207 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE 266
Query: 331 NTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 388
+ L H G + L+++ + I++ D T +WD +TGE H L
Sbjct: 267 DG-NLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 325
Query: 389 LRF-NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGD 445
+ + NN +CS D I V + + + GH VN + +D + S S D
Sbjct: 326 VDWQNNTTFASCSTDMCIHVCRLGCDRPV---KTFQGHTNEVNAIKWDPSGMLLASCSDD 382
Query: 446 RTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-----------LVVSGSSDNTIRLWDIE 494
T+K+W+ + L H + I +++ ++ S S D+T+RLWDIE
Sbjct: 383 MTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE 442
Query: 495 CGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 532
G C L H+E V + F D K + SG++D + +W+
Sbjct: 443 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 482
Score = 69.3 bits (168), Expect = 1e-11
Identities = 69/320 (21%), Positives = 125/320 (39%), Gaps = 89/320 (27%)
Query: 338 ILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVN---TGEMLNTLIHHC--------- 383
+L GH V ++ ++ +GS DST R+W++N G ++ HC
Sbjct: 176 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235
Query: 384 --EAVLHLRFN-NG-MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 437
+ V L +N NG ++ T S D +W D L L H+ + + ++ K
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIW----TEDGNLASTLGQHKGPIFALKWNRKGN 291
Query: 438 YIVSASGDRTIKVWNTSTCEF--------------------------------------- 458
YI+SA D+T +W+ T E
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 351
Query: 459 --VRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF 514
V+T GH + +++ L+ S S D T+++W ++ C+ L+ H + + I++
Sbjct: 352 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKW 411
Query: 515 -----------DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF 563
N + S ++D +++WD+ +C TL +H V+ + F
Sbjct: 412 SPTGPATSNPNSNIMLASASFDSTVRLWDIERG---------VCTHTLTKHQEPVYSVAF 462
Query: 564 --DEFQIVSSSHDDTILIWD 581
D + S S D + IW+
Sbjct: 463 SPDGKYLASGSFDKCVHIWN 482
Score = 59.3 bits (142), Expect = 1e-08
Identities = 51/235 (21%), Positives = 96/235 (40%), Gaps = 20/235 (8%)
Query: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITG-SSDSTVRVWDVNTGE 374
I+S D T IWD +T E K+ H+ L + + S+D + V +
Sbjct: 293 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDR 352
Query: 375 MLNTLIHHCEAVLHLRFN-NGMMV-TCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 432
+ T H V ++++ +GM++ +CS D ++ +W M I L H + +
Sbjct: 353 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCI---HDLQAHNKEIYTI 409
Query: 433 DFDDK-----------YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLV 479
+ + SAS D T+++W+ TL H+ + + + + +
Sbjct: 410 KWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYL 469
Query: 480 VSGSSDNTIRLWDIECGACLRVLEGHEELVR-CIRFDNKRIVSGAYDGKIKVWDL 533
SGS D + +W+ + G + G + C ++ + A DG + V DL
Sbjct: 470 ASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 524
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.134 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,727,687
Number of Sequences: 37866
Number of extensions: 1076470
Number of successful extensions: 6274
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 179
Number of HSP's successfully gapped in prelim test: 170
Number of HSP's that attempted gapping in prelim test: 2665
Number of HSP's gapped (non-prelim): 1493
length of query: 605
length of database: 18,247,518
effective HSP length: 108
effective length of query: 497
effective length of database: 14,157,990
effective search space: 7036521030
effective search space used: 7036521030
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.