Search of human proteins with 157885806

Search of human proteins with 157885806

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157885806 chromosome 12 open reading frame 51 [Homo sapiens]
         (3996 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157885806 chromosome 12 open reading frame 51 [Homo sapiens]      7947   0.0  
gi|126032348 hect domain and RLD 2 [Homo sapiens]                     162   5e-39
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]   151   1e-35
gi|157738609 HECT domain containing 3 [Homo sapiens]                  108   8e-23
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...    92   1e-17
gi|114520609 neural precursor cell expressed, developmentally do...    77   3e-13
gi|114520607 neural precursor cell expressed, developmentally do...    77   3e-13
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]               77   3e-13
gi|222352183 neural precursor cell expressed, developmentally do...    73   6e-12
gi|21361472 neural precursor cell expressed, developmentally dow...    73   6e-12
gi|222352094 neural precursor cell expressed, developmentally do...    73   6e-12
gi|222352092 neural precursor cell expressed, developmentally do...    73   6e-12
gi|222352090 neural precursor cell expressed, developmentally do...    73   6e-12
gi|222352088 neural precursor cell expressed, developmentally do...    73   6e-12
gi|222352086 neural precursor cell expressed, developmentally do...    73   6e-12
gi|222352084 neural precursor cell expressed, developmentally do...    73   6e-12
gi|222352082 neural precursor cell expressed, developmentally do...    73   6e-12
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H...    71   2e-11
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H...    71   2e-11
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]       70   4e-11
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]                70   4e-11
gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]                70   4e-11
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa...    65   1e-09
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote...    64   4e-09
gi|87116668 hypothetical protein LOC9870 [Homo sapiens]                62   1e-08
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi...    60   4e-08
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]       60   4e-08
gi|7657152 hect domain and RLD 3 [Homo sapiens]                        55   1e-06
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [...    55   2e-06
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i...    54   4e-06

>gi|157885806 chromosome 12 open reading frame 51 [Homo sapiens]
          Length = 3996

 Score = 7947 bits (20620), Expect = 0.0
 Identities = 3996/3996 (100%), Positives = 3996/3996 (100%)

Query: 1    MPANHLPIGSTMSTVHLSSDGTYFYWIWSPASLNEKTPKGHSVFMDIFELVVENGVFVAN 60
            MPANHLPIGSTMSTVHLSSDGTYFYWIWSPASLNEKTPKGHSVFMDIFELVVENGVFVAN
Sbjct: 1    MPANHLPIGSTMSTVHLSSDGTYFYWIWSPASLNEKTPKGHSVFMDIFELVVENGVFVAN 60

Query: 61   PLQERTILMRKEGESAKSINEMLLSRLSRYRASPSATLAALTGSTISNTLKEDQAANTSC 120
            PLQERTILMRKEGESAKSINEMLLSRLSRYRASPSATLAALTGSTISNTLKEDQAANTSC
Sbjct: 61   PLQERTILMRKEGESAKSINEMLLSRLSRYRASPSATLAALTGSTISNTLKEDQAANTSC 120

Query: 121  GLPLKMLRKTPIYTCGTYLVMLVPPPGGSGSSATRSLFGGTSGLSSLKRACYDTVNNMLW 180
            GLPLKMLRKTPIYTCGTYLVMLVPPPGGSGSSATRSLFGGTSGLSSLKRACYDTVNNMLW
Sbjct: 121  GLPLKMLRKTPIYTCGTYLVMLVPPPGGSGSSATRSLFGGTSGLSSLKRACYDTVNNMLW 180

Query: 181  TCSNDYIDQWCNPGNQAFHYVCQRLGVSHIITEPKEEAITTNEVINQLLHHVGAMCIHQL 240
            TCSNDYIDQWCNPGNQAFHYVCQRLGVSHIITEPKEEAITTNEVINQLLHHVGAMCIHQL
Sbjct: 181  TCSNDYIDQWCNPGNQAFHYVCQRLGVSHIITEPKEEAITTNEVINQLLHHVGAMCIHQL 240

Query: 241  NLLATNPNLPITSVLGKQHPIEAHHLSSICDIMEKAMVNGDTCIIRCILVVFQVVFKFFF 300
            NLLATNPNLPITSVLGKQHPIEAHHLSSICDIMEKAMVNGDTCIIRCILVVFQVVFKFFF
Sbjct: 241  NLLATNPNLPITSVLGKQHPIEAHHLSSICDIMEKAMVNGDTCIIRCILVVFQVVFKFFF 300

Query: 301  SPQTERNRDIIRRSGLLLWQLLMAPKDQICPEIQKEVCLAISSGLNILYPGETEINNLLK 360
            SPQTERNRDIIRRSGLLLWQLLMAPKDQICPEIQKEVCLAISSGLNILYPGETEINNLLK
Sbjct: 301  SPQTERNRDIIRRSGLLLWQLLMAPKDQICPEIQKEVCLAISSGLNILYPGETEINNLLK 360

Query: 361  LVLTEGERNSGLSQLRDVILTNLAEQLQNNRFGSDEDDHYRLNDELLHYILKIVVRESCI 420
            LVLTEGERNSGLSQLRDVILTNLAEQLQNNRFGSDEDDHYRLNDELLHYILKIVVRESCI
Sbjct: 361  LVLTEGERNSGLSQLRDVILTNLAEQLQNNRFGSDEDDHYRLNDELLHYILKIVVRESCI 420

Query: 421  LITKCQTVSKDDFQKLLSTVPAASSCLRYLMAVQNHLLSNTILIKPDENDDSDSSLQGET 480
            LITKCQTVSKDDFQKLLSTVPAASSCLRYLMAVQNHLLSNTILIKPDENDDSDSSLQGET
Sbjct: 421  LITKCQTVSKDDFQKLLSTVPAASSCLRYLMAVQNHLLSNTILIKPDENDDSDSSLQGET 480

Query: 481  LKVQELKVSILALATQILTGCDEVLEMLQQVTTALINSDIADREQRLKGLEQVTKATMLG 540
            LKVQELKVSILALATQILTGCDEVLEMLQQVTTALINSDIADREQRLKGLEQVTKATMLG
Sbjct: 481  LKVQELKVSILALATQILTGCDEVLEMLQQVTTALINSDIADREQRLKGLEQVTKATMLG 540

Query: 541  HLLPVLLTSLMHPNLQTLIMADALMPQLVQLVLYTSQTALLLKTQCPVFAEVGCSPCGAP 600
            HLLPVLLTSLMHPNLQTLIMADALMPQLVQLVLYTSQTALLLKTQCPVFAEVGCSPCGAP
Sbjct: 541  HLLPVLLTSLMHPNLQTLIMADALMPQLVQLVLYTSQTALLLKTQCPVFAEVGCSPCGAP 600

Query: 601  DQKCRLFPDERMLEEKEEPGFLTGLKIPAPWAAGKTVETVHPVRDNYKFKETVHIPGARC 660
            DQKCRLFPDERMLEEKEEPGFLTGLKIPAPWAAGKTVETVHPVRDNYKFKETVHIPGARC
Sbjct: 601  DQKCRLFPDERMLEEKEEPGFLTGLKIPAPWAAGKTVETVHPVRDNYKFKETVHIPGARC 660

Query: 661  LYLRFDSRCSSQYDYDKLVIYAGPNTNSRKVAEYGGNTLGYGSRSVLGTGWPKDLVKCIS 720
            LYLRFDSRCSSQYDYDKLVIYAGPNTNSRKVAEYGGNTLGYGSRSVLGTGWPKDLVKCIS
Sbjct: 661  LYLRFDSRCSSQYDYDKLVIYAGPNTNSRKVAEYGGNTLGYGSRSVLGTGWPKDLVKCIS 720

Query: 721  PPSLNFKVEGDTVTFSFEMRSGREHNTPDKAMWGFACTVRAQESSEDVSGGLPFLVDLAL 780
            PPSLNFKVEGDTVTFSFEMRSGREHNTPDKAMWGFACTVRAQESSEDVSGGLPFLVDLAL
Sbjct: 721  PPSLNFKVEGDTVTFSFEMRSGREHNTPDKAMWGFACTVRAQESSEDVSGGLPFLVDLAL 780

Query: 781  GLSVLACSMLRILYNGPEITKEEEACQELLRSKLLQRCQWQVEANGVISPALTPSPSPLP 840
            GLSVLACSMLRILYNGPEITKEEEACQELLRSKLLQRCQWQVEANGVISPALTPSPSPLP
Sbjct: 781  GLSVLACSMLRILYNGPEITKEEEACQELLRSKLLQRCQWQVEANGVISPALTPSPSPLP 840

Query: 841  LTIEEDREFTYPSDVLVPPVGNYFDLPRIRLPPGIMIKLREISGRARPQFRPSIKEVIQP 900
            LTIEEDREFTYPSDVLVPPVGNYFDLPRIRLPPGIMIKLREISGRARPQFRPSIKEVIQP
Sbjct: 841  LTIEEDREFTYPSDVLVPPVGNYFDLPRIRLPPGIMIKLREISGRARPQFRPSIKEVIQP 900

Query: 901  DVMEEMVVSCVIKHLNLVDALQSLINFQYQEEHAEEYDLLCKIMGETFKKLNAMERQLQS 960
            DVMEEMVVSCVIKHLNLVDALQSLINFQYQEEHAEEYDLLCKIMGETFKKLNAMERQLQS
Sbjct: 901  DVMEEMVVSCVIKHLNLVDALQSLINFQYQEEHAEEYDLLCKIMGETFKKLNAMERQLQS 960

Query: 961  VAELEQKWQSEVDDAMQGKLENNMPFFYDYHFNENKMKELELLCSMKEVSFDGNDLENMV 1020
            VAELEQKWQSEVDDAMQGKLENNMPFFYDYHFNENKMKELELLCSMKEVSFDGNDLENMV
Sbjct: 961  VAELEQKWQSEVDDAMQGKLENNMPFFYDYHFNENKMKELELLCSMKEVSFDGNDLENMV 1020

Query: 1021 LSLREKFLQEVNSLIQKPSHPLAKTKTLVKSLMNRAELLLHVTIAAQSGLTRSISGTPAE 1080
            LSLREKFLQEVNSLIQKPSHPLAKTKTLVKSLMNRAELLLHVTIAAQSGLTRSISGTPAE
Sbjct: 1021 LSLREKFLQEVNSLIQKPSHPLAKTKTLVKSLMNRAELLLHVTIAAQSGLTRSISGTPAE 1080

Query: 1081 TPACKSASETKVISHAVRQPVFLRSMSAPSDLEMIGNEDLEFTRANQRRRHVTSHRSSSF 1140
            TPACKSASETKVISHAVRQPVFLRSMSAPSDLEMIGNEDLEFTRANQRRRHVTSHRSSSF
Sbjct: 1081 TPACKSASETKVISHAVRQPVFLRSMSAPSDLEMIGNEDLEFTRANQRRRHVTSHRSSSF 1140

Query: 1141 TLLQSLAIEDSRDKPTYSVLLGQLFAFIGTNPDQAVSSSSFLLAAQTRWRRGNTRKQALV 1200
            TLLQSLAIEDSRDKPTYSVLLGQLFAFIGTNPDQAVSSSSFLLAAQTRWRRGNTRKQALV
Sbjct: 1141 TLLQSLAIEDSRDKPTYSVLLGQLFAFIGTNPDQAVSSSSFLLAAQTRWRRGNTRKQALV 1200

Query: 1201 HMRELLTAAVRVGGVTHLVGPVTMVLQGGPRIEELTCGGMVEQVQEAFGETMTSVVSLCA 1260
            HMRELLTAAVRVGGVTHLVGPVTMVLQGGPRIEELTCGGMVEQVQEAFGETMTSVVSLCA
Sbjct: 1201 HMRELLTAAVRVGGVTHLVGPVTMVLQGGPRIEELTCGGMVEQVQEAFGETMTSVVSLCA 1260

Query: 1261 RYPIACANSIGLLCTIPYTRSEEKCLVRSGLVQLMDRLCSLSNQTESSSSEKQTKKQKVA 1320
            RYPIACANSIGLLCTIPYTRSEEKCLVRSGLVQLMDRLCSLSNQTESSSSEKQTKKQKVA
Sbjct: 1261 RYPIACANSIGLLCTIPYTRSEEKCLVRSGLVQLMDRLCSLSNQTESSSSEKQTKKQKVA 1320

Query: 1321 TMAWAAFQVLANRCVEWEKEEGGSTEAVHSGLARQVSSLLTNHLARATECCGNQAAGNDA 1380
            TMAWAAFQVLANRCVEWEKEEGGSTEAVHSGLARQVSSLLTNHLARATECCGNQAAGNDA
Sbjct: 1321 TMAWAAFQVLANRCVEWEKEEGGSTEAVHSGLARQVSSLLTNHLARATECCGNQAAGNDA 1380

Query: 1381 LQDVLSLLNDLSRSHIGKAILSQPACVSKLLSLLLDQRPSPKLVLIILQLCRAALPLMSV 1440
            LQDVLSLLNDLSRSHIGKAILSQPACVSKLLSLLLDQRPSPKLVLIILQLCRAALPLMSV
Sbjct: 1381 LQDVLSLLNDLSRSHIGKAILSQPACVSKLLSLLLDQRPSPKLVLIILQLCRAALPLMSV 1440

Query: 1441 EDCGNVELPPWSYSVPSLNSEQEDPSDPASKIASLLLAKLADYVVPGCQTVLSPTASEPD 1500
            EDCGNVELPPWSYSVPSLNSEQEDPSDPASKIASLLLAKLADYVVPGCQTVLSPTASEPD
Sbjct: 1441 EDCGNVELPPWSYSVPSLNSEQEDPSDPASKIASLLLAKLADYVVPGCQTVLSPTASEPD 1500

Query: 1501 TTLTKTSPKNSLKGDKDPGEESEAVDGKLSIFIHKREDQSSHEVLQPLLSSSEGRPFRLG 1560
            TTLTKTSPKNSLKGDKDPGEESEAVDGKLSIFIHKREDQSSHEVLQPLLSSSEGRPFRLG
Sbjct: 1501 TTLTKTSPKNSLKGDKDPGEESEAVDGKLSIFIHKREDQSSHEVLQPLLSSSEGRPFRLG 1560

Query: 1561 TGANMEKVVKMDRDMTKGGCCEVITEEAAAALRKATKWAQSGLIVSIGPPVESINPETVS 1620
            TGANMEKVVKMDRDMTKGGCCEVITEEAAAALRKATKWAQSGLIVSIGPPVESINPETVS
Sbjct: 1561 TGANMEKVVKMDRDMTKGGCCEVITEEAAAALRKATKWAQSGLIVSIGPPVESINPETVS 1620

Query: 1621 GLSTGDKKKTAQTSICRERNSELARTDPVRPFISGHVANSMAAEVIALLHSLLMAPESNA 1680
            GLSTGDKKKTAQTSICRERNSELARTDPVRPFISGHVANSMAAEVIALLHSLLMAPESNA
Sbjct: 1621 GLSTGDKKKTAQTSICRERNSELARTDPVRPFISGHVANSMAAEVIALLHSLLMAPESNA 1680

Query: 1681 AQIWTTTAEKVLSRALMYIPQLGKYAESILENGSSSGRKLAKLQRIARQAVAALCALGGF 1740
            AQIWTTTAEKVLSRALMYIPQLGKYAESILENGSSSGRKLAKLQRIARQAVAALCALGGF
Sbjct: 1681 AQIWTTTAEKVLSRALMYIPQLGKYAESILENGSSSGRKLAKLQRIARQAVAALCALGGF 1740

Query: 1741 KETIKIGSEVQVLGRGISGSIGVVASINEQEGIATVRFPPIDCRKTSQASDTLTIPLSRL 1800
            KETIKIGSEVQVLGRGISGSIGVVASINEQEGIATVRFPPIDCRKTSQASDTLTIPLSRL
Sbjct: 1741 KETIKIGSEVQVLGRGISGSIGVVASINEQEGIATVRFPPIDCRKTSQASDTLTIPLSRL 1800

Query: 1801 CVPRSEALPLHKLSITEKVVQAVQSMLLPQEGSLSIHTSLPATGDGSAPVMAVVRLLAEI 1860
            CVPRSEALPLHKLSITEKVVQAVQSMLLPQEGSLSIHTSLPATGDGSAPVMAVVRLLAEI
Sbjct: 1801 CVPRSEALPLHKLSITEKVVQAVQSMLLPQEGSLSIHTSLPATGDGSAPVMAVVRLLAEI 1860

Query: 1861 RTRACLVMAQLLEDSLFCEEFIQQCPAAVEVLNLVAQECSAGERLAVVEVQCERLRMLYR 1920
            RTRACLVMAQLLEDSLFCEEFIQQCPAAVEVLNLVAQECSAGERLAVVEVQCERLRMLYR
Sbjct: 1861 RTRACLVMAQLLEDSLFCEEFIQQCPAAVEVLNLVAQECSAGERLAVVEVQCERLRMLYR 1920

Query: 1921 DCARPPPPPLQADRRQPKEITWSPSRVFPPVRACMFSSHLTSVTFLADPSAGGGLPRGTF 1980
            DCARPPPPPLQADRRQPKEITWSPSRVFPPVRACMFSSHLTSVTFLADPSAGGGLPRGTF
Sbjct: 1921 DCARPPPPPLQADRRQPKEITWSPSRVFPPVRACMFSSHLTSVTFLADPSAGGGLPRGTF 1980

Query: 1981 IYATSPLPVQAPSFYWEIEIVSYGDTDDDTGPIVSFGFTTEAEKRDGAWTNPVGTCLFHN 2040
            IYATSPLPVQAPSFYWEIEIVSYGDTDDDTGPIVSFGFTTEAEKRDGAWTNPVGTCLFHN
Sbjct: 1981 IYATSPLPVQAPSFYWEIEIVSYGDTDDDTGPIVSFGFTTEAEKRDGAWTNPVGTCLFHN 2040

Query: 2041 NGRAVHYNGSSLLQWKSVRLDVTLSPGDVAGIGWERTEGTPPPPGQPAKGRVYFTYCGQR 2100
            NGRAVHYNGSSLLQWKSVRLDVTLSPGDVAGIGWERTEGTPPPPGQPAKGRVYFTYCGQR
Sbjct: 2041 NGRAVHYNGSSLLQWKSVRLDVTLSPGDVAGIGWERTEGTPPPPGQPAKGRVYFTYCGQR 2100

Query: 2101 LSPYLEDVSGGMWPVVHIQKKNTKTRANFGSRPFAYAEGQAHRNAADLCTDLAEEISANF 2160
            LSPYLEDVSGGMWPVVHIQKKNTKTRANFGSRPFAYAEGQAHRNAADLCTDLAEEISANF
Sbjct: 2101 LSPYLEDVSGGMWPVVHIQKKNTKTRANFGSRPFAYAEGQAHRNAADLCTDLAEEISANF 2160

Query: 2161 EALPFAMASDSDNDAGTSIASDPGTHGPPCRIAAVATAQQQYDSDTSCHYKVELSYENFI 2220
            EALPFAMASDSDNDAGTSIASDPGTHGPPCRIAAVATAQQQYDSDTSCHYKVELSYENFI
Sbjct: 2161 EALPFAMASDSDNDAGTSIASDPGTHGPPCRIAAVATAQQQYDSDTSCHYKVELSYENFI 2220

Query: 2221 TSGPDPHPPPIADDESDDDDDDDIPQEDHYALLVKAWETKVFPTIRRRFRNEAERKSGLD 2280
            TSGPDPHPPPIADDESDDDDDDDIPQEDHYALLVKAWETKVFPTIRRRFRNEAERKSGLD
Sbjct: 2221 TSGPDPHPPPIADDESDDDDDDDIPQEDHYALLVKAWETKVFPTIRRRFRNEAERKSGLD 2280

Query: 2281 QIKGALQLGMVDIARQTVEFLYEENGGIPRDLYLPTIEDIKDEANKFTIDKVRKGLTVVT 2340
            QIKGALQLGMVDIARQTVEFLYEENGGIPRDLYLPTIEDIKDEANKFTIDKVRKGLTVVT
Sbjct: 2281 QIKGALQLGMVDIARQTVEFLYEENGGIPRDLYLPTIEDIKDEANKFTIDKVRKGLTVVT 2340

Query: 2341 RSPDSNNVASSAVGTALPKFAIRGMLKTFGLHGVVLDVDSVNELVQVETYLRSEGVLVRY 2400
            RSPDSNNVASSAVGTALPKFAIRGMLKTFGLHGVVLDVDSVNELVQVETYLRSEGVLVRY
Sbjct: 2341 RSPDSNNVASSAVGTALPKFAIRGMLKTFGLHGVVLDVDSVNELVQVETYLRSEGVLVRY 2400

Query: 2401 WYPIDMLERPPAGYRRTATNGLVTLDNTNLQIHRELLRCEAALARLYCRMALLNIFAPKL 2460
            WYPIDMLERPPAGYRRTATNGLVTLDNTNLQIHRELLRCEAALARLYCRMALLNIFAPKL
Sbjct: 2401 WYPIDMLERPPAGYRRTATNGLVTLDNTNLQIHRELLRCEAALARLYCRMALLNIFAPKL 2460

Query: 2461 PHLFTRLFHIPAIRDITLEHLQLLSNQLLAPPLPDGTISSSSILLAQSLQHCIHSQNCSA 2520
            PHLFTRLFHIPAIRDITLEHLQLLSNQLLAPPLPDGTISSSSILLAQSLQHCIHSQNCSA
Sbjct: 2461 PHLFTRLFHIPAIRDITLEHLQLLSNQLLAPPLPDGTISSSSILLAQSLQHCIHSQNCSA 2520

Query: 2521 TDLFYQGNSQTVREWLNVAITRTLHQGEESLLELTKQICSFLQTAPEQFPSEEFPISESK 2580
            TDLFYQGNSQTVREWLNVAITRTLHQGEESLLELTKQICSFLQTAPEQFPSEEFPISESK
Sbjct: 2521 TDLFYQGNSQTVREWLNVAITRTLHQGEESLLELTKQICSFLQTAPEQFPSEEFPISESK 2580

Query: 2581 VNMDVNFPGAAFVVVSCKESQSGFRKDSSLYKAPWARVLVYGLGHKVKRNGQLNLIEAAC 2640
            VNMDVNFPGAAFVVVSCKESQSGFRKDSSLYKAPWARVLVYGLGHKVKRNGQLNLIEAAC
Sbjct: 2581 VNMDVNFPGAAFVVVSCKESQSGFRKDSSLYKAPWARVLVYGLGHKVKRNGQLNLIEAAC 2640

Query: 2641 YPRDASPANTGLAPPPTADQYPSVVLSTDRVHIKLGVSPPPGAVLVLHSLPLEFPLAMAF 2700
            YPRDASPANTGLAPPPTADQYPSVVLSTDRVHIKLGVSPPPGAVLVLHSLPLEFPLAMAF
Sbjct: 2641 YPRDASPANTGLAPPPTADQYPSVVLSTDRVHIKLGVSPPPGAVLVLHSLPLEFPLAMAF 2700

Query: 2701 AEQLLSWKSEDSEGKSEDEPDTIPTSVLLQVVELLGNFLWTTDMAACVKELVFHLLAELL 2760
            AEQLLSWKSEDSEGKSEDEPDTIPTSVLLQVVELLGNFLWTTDMAACVKELVFHLLAELL
Sbjct: 2701 AEQLLSWKSEDSEGKSEDEPDTIPTSVLLQVVELLGNFLWTTDMAACVKELVFHLLAELL 2760

Query: 2761 RTVHTLEQRRHPAGLSSSIALQLNPCLAMLMALQSELHKLYDEETQNWVSGGACGGSGGA 2820
            RTVHTLEQRRHPAGLSSSIALQLNPCLAMLMALQSELHKLYDEETQNWVSGGACGGSGGA
Sbjct: 2761 RTVHTLEQRRHPAGLSSSIALQLNPCLAMLMALQSELHKLYDEETQNWVSGGACGGSGGA 2820

Query: 2821 AAGDQGRFSTYFHALMEGCLAVAEVTLPTNMSVTASGVTSATAPNLSDSSSSSSSSPGQT 2880
            AAGDQGRFSTYFHALMEGCLAVAEVTLPTNMSVTASGVTSATAPNLSDSSSSSSSSPGQT
Sbjct: 2821 AAGDQGRFSTYFHALMEGCLAVAEVTLPTNMSVTASGVTSATAPNLSDSSSSSSSSPGQT 2880

Query: 2881 PQSPSLLSKRKKVKMKREKASSSGKRQSSRTVDSDPTVLSIGGSKPEDMLWFHRALTLLI 2940
            PQSPSLLSKRKKVKMKREKASSSGKRQSSRTVDSDPTVLSIGGSKPEDMLWFHRALTLLI
Sbjct: 2881 PQSPSLLSKRKKVKMKREKASSSGKRQSSRTVDSDPTVLSIGGSKPEDMLWFHRALTLLI 2940

Query: 2941 ILRHLTRKDPQGLGVTSDAIADACQALVGPTAHSRLLVISGIPTHLDEGVVRGAIRKACN 3000
            ILRHLTRKDPQGLGVTSDAIADACQALVGPTAHSRLLVISGIPTHLDEGVVRGAIRKACN
Sbjct: 2941 ILRHLTRKDPQGLGVTSDAIADACQALVGPTAHSRLLVISGIPTHLDEGVVRGAIRKACN 3000

Query: 3001 AHGGVFKDEIYIPLQEEDTKKPKDKAEGGDGKVEPEKTLAFPGTDSMEVSTSSSLTPAMS 3060
            AHGGVFKDEIYIPLQEEDTKKPKDKAEGGDGKVEPEKTLAFPGTDSMEVSTSSSLTPAMS
Sbjct: 3001 AHGGVFKDEIYIPLQEEDTKKPKDKAEGGDGKVEPEKTLAFPGTDSMEVSTSSSLTPAMS 3060

Query: 3061 ISASASTSQASICSSQGISQTVSDLSVDPLPAGLELPIPPGLLEPHAVSSQESLDISLCS 3120
            ISASASTSQASICSSQGISQTVSDLSVDPLPAGLELPIPPGLLEPHAVSSQESLDISLCS
Sbjct: 3061 ISASASTSQASICSSQGISQTVSDLSVDPLPAGLELPIPPGLLEPHAVSSQESLDISLCS 3120

Query: 3121 TGSLGSLGSLGEPLDNAETASVSDMGSMYTVTSLDNQPLAARPIKGFAVVEIRSRAKIEK 3180
            TGSLGSLGSLGEPLDNAETASVSDMGSMYTVTSLDNQPLAARPIKGFAVVEIRSRAKIEK
Sbjct: 3121 TGSLGSLGSLGEPLDNAETASVSDMGSMYTVTSLDNQPLAARPIKGFAVVEIRSRAKIEK 3180

Query: 3181 IRASLFNNNDLIGLSSLDGEDELMEMSTEEILTVSVVNQSLFDTQGSPGLEDYFNDKSIK 3240
            IRASLFNNNDLIGLSSLDGEDELMEMSTEEILTVSVVNQSLFDTQGSPGLEDYFNDKSIK
Sbjct: 3181 IRASLFNNNDLIGLSSLDGEDELMEMSTEEILTVSVVNQSLFDTQGSPGLEDYFNDKSIK 3240

Query: 3241 GEKLVPGAREVLTEIFKSCAHSEQTLSLTPAKPIRVSDIYLSKEQINSQTPGNLLHLFFT 3300
            GEKLVPGAREVLTEIFKSCAHSEQTLSLTPAKPIRVSDIYLSKEQINSQTPGNLLHLFFT
Sbjct: 3241 GEKLVPGAREVLTEIFKSCAHSEQTLSLTPAKPIRVSDIYLSKEQINSQTPGNLLHLFFT 3300

Query: 3301 NVRPPKKVLEDQLTQILRKYGVPKPKFDKSKYSKAGKEQHPVKVVSTKRPITKPPAKDKA 3360
            NVRPPKKVLEDQLTQILRKYGVPKPKFDKSKYSKAGKEQHPVKVVSTKRPITKPPAKDKA
Sbjct: 3301 NVRPPKKVLEDQLTQILRKYGVPKPKFDKSKYSKAGKEQHPVKVVSTKRPITKPPAKDKA 3360

Query: 3361 VLNSVSRTALSEKKPTVKPKSPEKSKPDEKDPEKSPTKKQEVPEEKYLTLEGFHKFVIDR 3420
            VLNSVSRTALSEKKPTVKPKSPEKSKPDEKDPEKSPTKKQEVPEEKYLTLEGFHKFVIDR
Sbjct: 3361 VLNSVSRTALSEKKPTVKPKSPEKSKPDEKDPEKSPTKKQEVPEEKYLTLEGFHKFVIDR 3420

Query: 3421 ARQDIRSVWRAILSCGYDLHFERCACIDVRHAQKASRKWTLEMDVALVQYINQLCRHLAI 3480
            ARQDIRSVWRAILSCGYDLHFERCACIDVRHAQKASRKWTLEMDVALVQYINQLCRHLAI
Sbjct: 3421 ARQDIRSVWRAILSCGYDLHFERCACIDVRHAQKASRKWTLEMDVALVQYINQLCRHLAI 3480

Query: 3481 TPARLHPHEVYLDPADAADPRVACLLNVPIESLRLRFALLQSLNTTLETFFLPLVELRQT 3540
            TPARLHPHEVYLDPADAADPRVACLLNVPIESLRLRFALLQSLNTTLETFFLPLVELRQT
Sbjct: 3481 TPARLHPHEVYLDPADAADPRVACLLNVPIESLRLRFALLQSLNTTLETFFLPLVELRQT 3540

Query: 3541 PMYTHSIAALLKEAKGLIFYDTKVTVMNRVLNATVQRTADHAAPEITLDPLEIVGGEIRA 3600
            PMYTHSIAALLKEAKGLIFYDTKVTVMNRVLNATVQRTADHAAPEITLDPLEIVGGEIRA
Sbjct: 3541 PMYTHSIAALLKEAKGLIFYDTKVTVMNRVLNATVQRTADHAAPEITLDPLEIVGGEIRA 3600

Query: 3601 SENSYFCQAARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVCK 3660
            SENSYFCQAARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVCK
Sbjct: 3601 SENSYFCQAARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVCK 3660

Query: 3661 ELQSSSLSLLLLCPSSAVNKNKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLD 3720
            ELQSSSLSLLLLCPSSAVNKNKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLD
Sbjct: 3661 ELQSSSLSLLLLCPSSAVNKNKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLD 3720

Query: 3721 LLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDETELEALCAEIASQHLATESP 3780
            LLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDETELEALCAEIASQHLATESP
Sbjct: 3721 LLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDETELEALCAEIASQHLATESP 3780

Query: 3781 DSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECVTAV 3840
            DSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECVTAV
Sbjct: 3781 DSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECVTAV 3840

Query: 3841 RAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIEFFWGAL 3900
            RAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIEFFWGAL
Sbjct: 3841 RAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIEFFWGAL 3900

Query: 3901 EMFTQEELCKFIKFACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGSPDSRYIR 3960
            EMFTQEELCKFIKFACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGSPDSRYIR
Sbjct: 3901 EMFTQEELCKFIKFACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGSPDSRYIR 3960

Query: 3961 VETCMFMIKLPQYSSLEIMLEKLRCAIHYREDPLSG 3996
            VETCMFMIKLPQYSSLEIMLEKLRCAIHYREDPLSG
Sbjct: 3961 VETCMFMIKLPQYSSLEIMLEKLRCAIHYREDPLSG 3996


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score =  162 bits (411), Expect = 5e-39
 Identities = 139/496 (28%), Positives = 227/496 (45%), Gaps = 57/496 (11%)

Query: 3505 LLNVPIESLRLRFALLQSLNTTLETFFLPLVELRQTPMYTHSIAAL-LKEAKGLIFYDTK 3563
            L  +PI +LR R  LL  L+  L    +P+ +L  +   T    ++     +G++    K
Sbjct: 4338 LQEIPIIALRNRLLLLHHLSE-LFCPCIPMFDLEGSLDETGLGPSVGFDTLRGILISQGK 4396

Query: 3564 VTVMNRVLNATVQRTADHAAPEITLDPLEIVGGEIRASENSYFCQAARQLASVPSSQLCV 3623
                 +V+ AT+ R   H  P + L+ +++     +         A          Q+C 
Sbjct: 4397 EAAFRKVVQATMVRDRQHG-PVVELNRIQVKRSRSKGG------LAGPDGTKSVFGQMCA 4449

Query: 3624 KLASGGD-----PTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSSAV 3678
            K++S G      P   + ++F GE V    G +   + ++C+ELQ+    LL++ P+   
Sbjct: 4450 KMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRD 4509

Query: 3679 NK--NKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDP 3736
                N+  Y+L+P+        +  FLG LLGIAIR   PL L+L    WK L G  L  
Sbjct: 4510 ESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSL-T 4568

Query: 3737 EQDLQEAD---ILTYNYVKKFESINDETELEALCAEIASQHLATESPDSPNKPCCRFTYL 3793
              DL E D   I    Y++  E+ ++E E  +L                       FT  
Sbjct: 4569 IADLSEVDKDFIPGLMYIRDNEATSEEFEAMSL----------------------PFTVP 4606

Query: 3794 TMTGEEVELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECVTAVRAGLGSIIPLQLL 3853
            + +G++++L S+  HI +  +N+  Y     + RL E    E V AVR G+  ++P+ LL
Sbjct: 4607 SASGQDIQLSSKHTHITL--DNRAEYVRLAINYRLHEFD--EQVAAVREGMARVVPVPLL 4662

Query: 3854 TMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIK 3913
            ++ +  E+E   CG P I L  LK+   Y+ G+  +   I++FW  +E F+  E   F++
Sbjct: 4663 SLFTGYELETMVCGSPDIPLHLLKSVATYK-GIEPSASLIQWFWEVMESFSNTERSLFLR 4721

Query: 3914 FACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQY 3973
            F   + R+P T     G      V     K  PPD     P+S      TC F++KLP+Y
Sbjct: 4722 FVWGRTRLPRTIADFRGRDFVIQVLD---KYNPPDHFL--PES-----YTCFFLLKLPRY 4771

Query: 3974 SSLEIMLEKLRCAIHY 3989
            S  +++ EKL+ AIH+
Sbjct: 4772 SCKQVLEEKLKYAIHF 4787



 Score = 41.6 bits (96), Expect = 0.016
 Identities = 20/49 (40%), Positives = 28/49 (57%)

Query: 637  VETVHPVRDNYKFKETVHIPGARCLYLRFDSRCSSQYDYDKLVIYAGPN 685
            VE+ HP  D+     TV IPGA  L + FD +CS++  +D L +  G N
Sbjct: 3614 VESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDGVN 3662


>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
          Length = 4861

 Score =  151 bits (381), Expect = 1e-35
 Identities = 135/504 (26%), Positives = 223/504 (44%), Gaps = 59/504 (11%)

Query: 3496 DAADPRVACLLNVPIESLRLRFALLQSLNTTLETFFLPLVELRQTPMYTHSIAALLKEAK 3555
            D   P+   L  V I ++R R  LL   +  + + +  L     +P   +S +       
Sbjct: 4380 DTVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLL---NLSPNNQNSTSHYNAGTW 4436

Query: 3556 GLIFYDTKVTVMNRVLNATVQRT-------ADHAAPEITLDPLEIVGGEIRASENSYFCQ 3608
            G++    +  +  RV    + R+         +  P+IT+  +   G + +      F Q
Sbjct: 4437 GIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKP----IFVQ 4492

Query: 3609 AARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLS 3668
             ARQ+  + +S L +       P+ A+ ++  GE      G F   + ++C+EL++  + 
Sbjct: 4493 IARQVVKLNASDLRL-------PSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVD 4545

Query: 3669 LLLLCPSSA--VNKNKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFW 3726
            LL+  P++   V  N+ +++  PS           FLG L+G+AIR   PL L L P  W
Sbjct: 4546 LLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVW 4605

Query: 3727 KTLVGEPLDPEQDLQEADILTYNYVKKFESINDETELEALCAEIASQHLATESPDSPNKP 3786
            K L   PL  E DL+E D+L    +     I D    E    E+               P
Sbjct: 4606 KQLCCVPLTLE-DLEEVDLLYVQTLNSILHIEDSGITEESFHEMI--------------P 4650

Query: 3787 CCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECVTAVRAGLGS 3846
               F   +  G+ V +   G  I + + N+  Y       RL E+     V AVR G+  
Sbjct: 4651 LDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQ--VAAVREGMSW 4708

Query: 3847 IIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQE 3906
            I+P+ LL++L+  ++E   CG+P I++E LK    Y+  + E  Q +++FW  LE F+ E
Sbjct: 4709 IVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EVDEQHQLVQWFWHTLEEFSNE 4767

Query: 3907 ELCKFIKFACNQERIPFTCPCKDGGPDTAHVPP--YPMKIAPPDGTAGSPDSRYIRVETC 3964
            E   F++F   + R+P          +TA +      MK+  P  +   P S     +TC
Sbjct: 4768 ERVLFMRFVSGRSRLP---------ANTADISQRFQIMKVDRPYDSL--PTS-----QTC 4811

Query: 3965 MFMIKLPQYSSLEIMLEKLRCAIH 3988
             F ++LP YSS  +M E+LR AI+
Sbjct: 4812 FFQLRLPPYSSQLVMAERLRYAIN 4835


>gi|157738609 HECT domain containing 3 [Homo sapiens]
          Length = 861

 Score =  108 bits (271), Expect = 8e-23
 Identities = 93/359 (25%), Positives = 159/359 (44%), Gaps = 50/359 (13%)

Query: 3638 RFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSSAVNKNKGK--------YILTP 3689
            +F  E +    G FR  L  + +EL  SS    +  P      N+G         Y+  P
Sbjct: 531  KFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNP 590

Query: 3690 SPITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYN 3749
            S   + + +   ++GQL+G A+R    L L L    WK L GE +   +D    D +   
Sbjct: 591  SCRDFAKYE---WIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVK 647

Query: 3750 YVKKFESINDETELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHI 3809
             ++  E ++ ET       E+                   FT +    + VEL   G  I
Sbjct: 648  LLEVMEGMDKETFEFKFGKELT------------------FTTVLSDQQVVELIPGGAGI 689

Query: 3810 LVAWENKDIYAAAIRSLRLRELQNVECVTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLP 3869
            +V + ++  +   ++  RL E +  E V A++AGL  ++P  +L +L+  E+E + CG P
Sbjct: 690  VVGYGDRSRFIQLVQKARLEESK--EQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDP 747

Query: 3870 YINLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIPFTCPCKD 3929
             + ++ L+  T ++     +D  +++FW AL  FT E+  +F++F   + R+P       
Sbjct: 748  EVTVDALRKLTRFE-DFEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLP------- 799

Query: 3930 GGPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAIH 3988
                 A +  YP K+   + T   P+S      TC   + LP Y+S ++  EKLR A +
Sbjct: 800  -----ARIYIYPDKLG-YETTDALPES-----STCSSTLFLPHYASAKVCEEKLRYAAY 847


>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
            protein ligase 1 [Homo sapiens]
          Length = 909

 Score = 91.7 bits (226), Expect = 1e-17
 Identities = 96/383 (25%), Positives = 148/383 (38%), Gaps = 51/383 (13%)

Query: 3611 RQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLL 3670
            R    V S   C KL  G        +RF GEE  G  G  R +   +  E+ +   +L 
Sbjct: 564  RSSCEVVSKANCAKLKQG------IAVRFHGEEGMG-QGVVREWFDILSNEIVNPDYALF 616

Query: 3671 LLCPSSAVNKNKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLV 3730
                     +      + P  + Y       F GQ+LG+A+     + +    SF+K ++
Sbjct: 617  TQSADGTTFQPNSNSYVNPDHLNY-----FRFAGQILGLALNHRQLVNIYFTRSFYKHIL 671

Query: 3731 GEPLDPEQDLQEADILTYNYVKKFESINDETELEALCAEIASQHLATESPDSPNKPCCRF 3790
            G P+    + Q+   +   Y K  + I D  ++  L  E+     + E            
Sbjct: 672  GIPV----NYQDVASIDPEYAKNLQWILD-NDISDLGLELT---FSVE------------ 711

Query: 3791 TYLTMTGEEVELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECVTAVRAGLGSIIPL 3850
            T +    EEV L   G  ILV   NK  Y   +  LR+      + + A   G    IP 
Sbjct: 712  TDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQ-INAFLQGFHMFIPP 770

Query: 3851 QLLTMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELCK 3910
             L+ +    E+EL   G+P I++     +T Y  G    D  I++FW  +E  TQEE   
Sbjct: 771  SLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVL 830

Query: 3911 FIKFACNQERIPFTCPCKDGGPD-----TAHVPPYPMKIAPPDGTAGSPDSRYIRVETCM 3965
             ++F     R+P        G       T    PY   + P                TC+
Sbjct: 831  LLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTS-------------STCI 877

Query: 3966 FMIKLPQYSSLEIMLEKLRCAIH 3988
             M+KLP+Y S EI+ ++L  A+H
Sbjct: 878  NMLKLPEYPSKEILKDRLLVALH 900


>gi|114520609 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 1 [Homo sapiens]
          Length = 900

 Score = 77.4 bits (189), Expect = 3e-13
 Identities = 85/359 (23%), Positives = 150/359 (41%), Gaps = 51/359 (14%)

Query: 3637 IRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSS----AVNKNKGKYILTPSPI 3692
            I F GE+     G  R + + + KE+ +    L     +      +N N G  +     +
Sbjct: 575  IEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSG--LCNEDHL 632

Query: 3693 TYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVK 3752
            +Y       F+G++ G+A+     L    +  F+K ++ +P+    D++  D   YN ++
Sbjct: 633  SY-----FKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLH-DMESVDSEYYNSLR 686

Query: 3753 KFESINDETELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVA 3812
                 ND TEL+     I  + L  ++                   + EL + G  I+V 
Sbjct: 687  WILE-NDPTELDLRF--IIDEELFGQT------------------HQHELKNGGSEIVVT 725

Query: 3813 WENKDIYAAAIRSLR-LRELQNVECVTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYI 3871
             +NK  Y   +   R +  +Q    + A + G   +IP  L+ +    E+EL  CGL  +
Sbjct: 726  NKNKKEYIYLVIQWRFVNRIQKQ--MAAFKEGFFELIPQDLIKIFDENELELLMCGLGDV 783

Query: 3872 NLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCK 3928
            ++   + HT Y+ G     Q I++FW A+ M   E+  + ++F     R+P   F     
Sbjct: 784  DVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYG 843

Query: 3929 DGGPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
              GP +  V  +           G+P+ +  R  TC   + LP Y S E + +KL+ AI
Sbjct: 844  SNGPQSFTVEQW-----------GTPE-KLPRAHTCFNRLDLPPYESFEELWDKLQMAI 890


>gi|114520607 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 2 [Homo sapiens]
          Length = 1247

 Score = 77.4 bits (189), Expect = 3e-13
 Identities = 85/359 (23%), Positives = 150/359 (41%), Gaps = 51/359 (14%)

Query: 3637 IRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSS----AVNKNKGKYILTPSPI 3692
            I F GE+     G  R + + + KE+ +    L     +      +N N G  +     +
Sbjct: 922  IEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSG--LCNEDHL 979

Query: 3693 TYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVK 3752
            +Y       F+G++ G+A+     L    +  F+K ++ +P+    D++  D   YN ++
Sbjct: 980  SY-----FKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLH-DMESVDSEYYNSLR 1033

Query: 3753 KFESINDETELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVA 3812
                 ND TEL+     I  + L  ++                   + EL + G  I+V 
Sbjct: 1034 WILE-NDPTELDLRF--IIDEELFGQT------------------HQHELKNGGSEIVVT 1072

Query: 3813 WENKDIYAAAIRSLR-LRELQNVECVTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYI 3871
             +NK  Y   +   R +  +Q    + A + G   +IP  L+ +    E+EL  CGL  +
Sbjct: 1073 NKNKKEYIYLVIQWRFVNRIQKQ--MAAFKEGFFELIPQDLIKIFDENELELLMCGLGDV 1130

Query: 3872 NLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCK 3928
            ++   + HT Y+ G     Q I++FW A+ M   E+  + ++F     R+P   F     
Sbjct: 1131 DVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYG 1190

Query: 3929 DGGPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
              GP +  V  +           G+P+ +  R  TC   + LP Y S E + +KL+ AI
Sbjct: 1191 SNGPQSFTVEQW-----------GTPE-KLPRAHTCFNRLDLPPYESFEELWDKLQMAI 1237


>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
          Length = 1083

 Score = 77.4 bits (189), Expect = 3e-13
 Identities = 98/378 (25%), Positives = 144/378 (38%), Gaps = 56/378 (14%)

Query: 3624 KLASGGDPTYAFNIRFTGEEVHGTS-------GSFRHFLWQVCKELQSSSLSLLLLCPSS 3676
            KL+   +P     IR      HG         G FR FL     EL  S  +     P+ 
Sbjct: 739  KLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFL----NELLKSGFN-----PNQ 789

Query: 3677 AVNKNKGKYILTPSP---ITYGEEQLLH--FLGQLLGIAIRADVPLPLDLLPSFWKTLVG 3731
               K   + +L P+P   +  G+    H  FLG++LG A+  ++ + L     F   L+G
Sbjct: 790  GFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLG 849

Query: 3732 EPLDPE-QDLQEADILTYNYVKKFESINDETELEALCAEIASQHLATESPDSPNKPCCRF 3790
               D +   L   D   Y  +   +S  D+ E   L   + +  L               
Sbjct: 850  TSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGE------------- 896

Query: 3791 TYLTMTGEEVELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECVTAVRAGLGSIIPL 3850
                   + VEL   G+ I V   N+  Y   +   RL       C+ A R GL +++ L
Sbjct: 897  ------AQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCL-AFRQGLANVVSL 949

Query: 3851 QLLTMLSPLEMELRTCGLPY-INLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELC 3909
            + L M    E+++   G    I+LE LK+ T Y  G       I+ FW  +E FT EE  
Sbjct: 950  EWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKR 1009

Query: 3910 KFIKFACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIK 3969
            K +KF  +  R P                 YP   A      GS   R     TCM ++K
Sbjct: 1010 KLLKFVTSCSRPPL----------LGFKELYP---AFCIHNGGSDLERLPTASTCMNLLK 1056

Query: 3970 LPQYSSLEIMLEKLRCAI 3987
            LP++    ++  KL  AI
Sbjct: 1057 LPEFYDETLLRSKLLYAI 1074


>gi|222352183 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 70/290 (24%), Positives = 127/290 (43%), Gaps = 40/290 (13%)

Query: 3702 FLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDET 3761
            F+G++ G+A+     L    +  F+K ++G+ +    D++  D   YN +K     ND T
Sbjct: 591  FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLN-DMESVDSEYYNSLKWILE-NDPT 648

Query: 3762 ELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAA 3821
            EL+ +   I  ++                TY      +V+L   G  I+V  ENK  Y  
Sbjct: 649  ELDLMFC-IDEENFGQ-------------TY------QVDLKPNGSEIMVTNENKREYID 688

Query: 3822 AIRSLRLRELQNVEC-VTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHT 3880
             +  ++ R +  V+  + A   G   ++P+ L+ +    E+EL  CGL  +++   + H+
Sbjct: 689  LV--IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 746

Query: 3881 MYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCKDGGPDTAHV 3937
            +Y+ G       I++FW A+ +   E+  + ++F     R+P   F       GP    +
Sbjct: 747  IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTI 806

Query: 3938 PPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
              +           GSP+ +  R  TC   + LP Y + E + EKL  A+
Sbjct: 807  EQW-----------GSPE-KLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844


>gi|21361472 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 70/290 (24%), Positives = 127/290 (43%), Gaps = 40/290 (13%)

Query: 3702 FLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDET 3761
            F+G++ G+A+     L    +  F+K ++G+ +    D++  D   YN +K     ND T
Sbjct: 692  FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLN-DMESVDSEYYNSLKWILE-NDPT 749

Query: 3762 ELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAA 3821
            EL+ +   I  ++                TY      +V+L   G  I+V  ENK  Y  
Sbjct: 750  ELDLMFC-IDEENFGQ-------------TY------QVDLKPNGSEIMVTNENKREYID 789

Query: 3822 AIRSLRLRELQNVEC-VTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHT 3880
             +  ++ R +  V+  + A   G   ++P+ L+ +    E+EL  CGL  +++   + H+
Sbjct: 790  LV--IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 847

Query: 3881 MYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCKDGGPDTAHV 3937
            +Y+ G       I++FW A+ +   E+  + ++F     R+P   F       GP    +
Sbjct: 848  IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTI 907

Query: 3938 PPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
              +           GSP+ +  R  TC   + LP Y + E + EKL  A+
Sbjct: 908  EQW-----------GSPE-KLPRAHTCFNRLDLPPYETFEDLREKLLMAV 945


>gi|222352094 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 70/290 (24%), Positives = 127/290 (43%), Gaps = 40/290 (13%)

Query: 3702 FLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDET 3761
            F+G++ G+A+     L    +  F+K ++G+ +    D++  D   YN +K     ND T
Sbjct: 571  FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLN-DMESVDSEYYNSLKWILE-NDPT 628

Query: 3762 ELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAA 3821
            EL+ +   I  ++                TY      +V+L   G  I+V  ENK  Y  
Sbjct: 629  ELDLMFC-IDEENFGQ-------------TY------QVDLKPNGSEIMVTNENKREYID 668

Query: 3822 AIRSLRLRELQNVEC-VTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHT 3880
             +  ++ R +  V+  + A   G   ++P+ L+ +    E+EL  CGL  +++   + H+
Sbjct: 669  LV--IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 726

Query: 3881 MYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCKDGGPDTAHV 3937
            +Y+ G       I++FW A+ +   E+  + ++F     R+P   F       GP    +
Sbjct: 727  IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTI 786

Query: 3938 PPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
              +           GSP+ +  R  TC   + LP Y + E + EKL  A+
Sbjct: 787  EQW-----------GSPE-KLPRAHTCFNRLDLPPYETFEDLREKLLMAV 824


>gi|222352092 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 70/290 (24%), Positives = 127/290 (43%), Gaps = 40/290 (13%)

Query: 3702 FLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDET 3761
            F+G++ G+A+     L    +  F+K ++G+ +    D++  D   YN +K     ND T
Sbjct: 571  FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLN-DMESVDSEYYNSLKWILE-NDPT 628

Query: 3762 ELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAA 3821
            EL+ +   I  ++                TY      +V+L   G  I+V  ENK  Y  
Sbjct: 629  ELDLMFC-IDEENFGQ-------------TY------QVDLKPNGSEIMVTNENKREYID 668

Query: 3822 AIRSLRLRELQNVEC-VTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHT 3880
             +  ++ R +  V+  + A   G   ++P+ L+ +    E+EL  CGL  +++   + H+
Sbjct: 669  LV--IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 726

Query: 3881 MYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCKDGGPDTAHV 3937
            +Y+ G       I++FW A+ +   E+  + ++F     R+P   F       GP    +
Sbjct: 727  IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTI 786

Query: 3938 PPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
              +           GSP+ +  R  TC   + LP Y + E + EKL  A+
Sbjct: 787  EQW-----------GSPE-KLPRAHTCFNRLDLPPYETFEDLREKLLMAV 824


>gi|222352090 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 70/290 (24%), Positives = 127/290 (43%), Gaps = 40/290 (13%)

Query: 3702 FLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDET 3761
            F+G++ G+A+     L    +  F+K ++G+ +    D++  D   YN +K     ND T
Sbjct: 684  FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLN-DMESVDSEYYNSLKWILE-NDPT 741

Query: 3762 ELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAA 3821
            EL+ +   I  ++                TY      +V+L   G  I+V  ENK  Y  
Sbjct: 742  ELDLMFC-IDEENFGQ-------------TY------QVDLKPNGSEIMVTNENKREYID 781

Query: 3822 AIRSLRLRELQNVEC-VTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHT 3880
             +  ++ R +  V+  + A   G   ++P+ L+ +    E+EL  CGL  +++   + H+
Sbjct: 782  LV--IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 839

Query: 3881 MYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCKDGGPDTAHV 3937
            +Y+ G       I++FW A+ +   E+  + ++F     R+P   F       GP    +
Sbjct: 840  IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTI 899

Query: 3938 PPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
              +           GSP+ +  R  TC   + LP Y + E + EKL  A+
Sbjct: 900  EQW-----------GSPE-KLPRAHTCFNRLDLPPYETFEDLREKLLMAV 937


>gi|222352088 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 70/290 (24%), Positives = 127/290 (43%), Gaps = 40/290 (13%)

Query: 3702 FLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDET 3761
            F+G++ G+A+     L    +  F+K ++G+ +    D++  D   YN +K     ND T
Sbjct: 704  FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLN-DMESVDSEYYNSLKWILE-NDPT 761

Query: 3762 ELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAA 3821
            EL+ +   I  ++                TY      +V+L   G  I+V  ENK  Y  
Sbjct: 762  ELDLMFC-IDEENFGQ-------------TY------QVDLKPNGSEIMVTNENKREYID 801

Query: 3822 AIRSLRLRELQNVEC-VTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHT 3880
             +  ++ R +  V+  + A   G   ++P+ L+ +    E+EL  CGL  +++   + H+
Sbjct: 802  LV--IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 859

Query: 3881 MYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCKDGGPDTAHV 3937
            +Y+ G       I++FW A+ +   E+  + ++F     R+P   F       GP    +
Sbjct: 860  IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTI 919

Query: 3938 PPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
              +           GSP+ +  R  TC   + LP Y + E + EKL  A+
Sbjct: 920  EQW-----------GSPE-KLPRAHTCFNRLDLPPYETFEDLREKLLMAV 957


>gi|222352086 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 1 [Homo sapiens]
          Length = 975

 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 70/290 (24%), Positives = 127/290 (43%), Gaps = 40/290 (13%)

Query: 3702 FLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDET 3761
            F+G++ G+A+     L    +  F+K ++G+ +    D++  D   YN +K     ND T
Sbjct: 712  FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLN-DMESVDSEYYNSLKWILE-NDPT 769

Query: 3762 ELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAA 3821
            EL+ +   I  ++                TY      +V+L   G  I+V  ENK  Y  
Sbjct: 770  ELDLMFC-IDEENFGQ-------------TY------QVDLKPNGSEIMVTNENKREYID 809

Query: 3822 AIRSLRLRELQNVEC-VTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHT 3880
             +  ++ R +  V+  + A   G   ++P+ L+ +    E+EL  CGL  +++   + H+
Sbjct: 810  LV--IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 867

Query: 3881 MYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCKDGGPDTAHV 3937
            +Y+ G       I++FW A+ +   E+  + ++F     R+P   F       GP    +
Sbjct: 868  IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTI 927

Query: 3938 PPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
              +           GSP+ +  R  TC   + LP Y + E + EKL  A+
Sbjct: 928  EQW-----------GSPE-KLPRAHTCFNRLDLPPYETFEDLREKLLMAV 965


>gi|222352084 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 70/290 (24%), Positives = 127/290 (43%), Gaps = 40/290 (13%)

Query: 3702 FLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDET 3761
            F+G++ G+A+     L    +  F+K ++G+ +    D++  D   YN +K     ND T
Sbjct: 591  FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLN-DMESVDSEYYNSLKWILE-NDPT 648

Query: 3762 ELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAA 3821
            EL+ +   I  ++                TY      +V+L   G  I+V  ENK  Y  
Sbjct: 649  ELDLMFC-IDEENFGQ-------------TY------QVDLKPNGSEIMVTNENKREYID 688

Query: 3822 AIRSLRLRELQNVEC-VTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHT 3880
             +  ++ R +  V+  + A   G   ++P+ L+ +    E+EL  CGL  +++   + H+
Sbjct: 689  LV--IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 746

Query: 3881 MYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCKDGGPDTAHV 3937
            +Y+ G       I++FW A+ +   E+  + ++F     R+P   F       GP    +
Sbjct: 747  IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTI 806

Query: 3938 PPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
              +           GSP+ +  R  TC   + LP Y + E + EKL  A+
Sbjct: 807  EQW-----------GSPE-KLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844


>gi|222352082 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 70/290 (24%), Positives = 127/290 (43%), Gaps = 40/290 (13%)

Query: 3702 FLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDET 3761
            F+G++ G+A+     L    +  F+K ++G+ +    D++  D   YN +K     ND T
Sbjct: 591  FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLN-DMESVDSEYYNSLKWILE-NDPT 648

Query: 3762 ELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAA 3821
            EL+ +   I  ++                TY      +V+L   G  I+V  ENK  Y  
Sbjct: 649  ELDLMFC-IDEENFGQ-------------TY------QVDLKPNGSEIMVTNENKREYID 688

Query: 3822 AIRSLRLRELQNVEC-VTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHT 3880
             +  ++ R +  V+  + A   G   ++P+ L+ +    E+EL  CGL  +++   + H+
Sbjct: 689  LV--IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 746

Query: 3881 MYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCKDGGPDTAHV 3937
            +Y+ G       I++FW A+ +   E+  + ++F     R+P   F       GP    +
Sbjct: 747  IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTI 806

Query: 3938 PPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
              +           GSP+ +  R  TC   + LP Y + E + EKL  A+
Sbjct: 807  EQW-----------GSPE-KLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844


>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
            sapiens]
          Length = 757

 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 96/417 (23%), Positives = 165/417 (39%), Gaps = 70/417 (16%)

Query: 3585 EITLDPLEIVGGEIRASENSYFCQAARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEV 3644
            E++L   +     I  S    F ++ RQ+  +    L  +L           ++F GEE 
Sbjct: 388  ELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLM----------VKFRGEEG 437

Query: 3645 HGTSGSFRHFLWQVCKEL----------QSSSLSLLLLCPSSAVNKNKGKYILTPSPITY 3694
                G  R +L+ +C E+           + ++ +L + P S++N         P  ++Y
Sbjct: 438  LDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSIN---------PDHLSY 488

Query: 3695 GEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADI-LTYNYVKK 3753
                  HF+G+++G+A+     +       F+K L+G+P+    DL+  D  L  + V  
Sbjct: 489  -----FHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLS-DLESVDPELHKSLVWI 542

Query: 3754 FESINDETEL--EALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILV 3811
             E  ND T +     C E  +     +    PN                     GR++ V
Sbjct: 543  LE--NDITPVLDHTFCVEHNAFGRILQHELKPN---------------------GRNVPV 579

Query: 3812 AWENKDIYAAAIRSLRLRELQNVEC-VTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPY 3870
              ENK  Y     + R   ++ +E    A++ G   +IP  LL      E+EL   GL  
Sbjct: 580  TEENKKEYVRLYVNWRF--MRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDK 637

Query: 3871 INLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIPFTCPCKDG 3930
            I+L   K++T  +  + +++  + +FW A+E F +E   + ++F     R+P     K  
Sbjct: 638  IDLNDWKSNTRLKHCVADSNI-VRWFWQAVETFDEERRARLLQFVTGSTRVPLQ-GFKAL 695

Query: 3931 GPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
               T    P    I   D           +  TC   I +P Y S E + EKL  A+
Sbjct: 696  QGSTGAAGPRLFTIHLIDANT----DNLPKAHTCFNRIDIPPYESYEKLYEKLLTAV 748


>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
            sapiens]
          Length = 731

 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 96/417 (23%), Positives = 165/417 (39%), Gaps = 70/417 (16%)

Query: 3585 EITLDPLEIVGGEIRASENSYFCQAARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEV 3644
            E++L   +     I  S    F ++ RQ+  +    L  +L           ++F GEE 
Sbjct: 362  ELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLM----------VKFRGEEG 411

Query: 3645 HGTSGSFRHFLWQVCKEL----------QSSSLSLLLLCPSSAVNKNKGKYILTPSPITY 3694
                G  R +L+ +C E+           + ++ +L + P S++N         P  ++Y
Sbjct: 412  LDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSIN---------PDHLSY 462

Query: 3695 GEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADI-LTYNYVKK 3753
                  HF+G+++G+A+     +       F+K L+G+P+    DL+  D  L  + V  
Sbjct: 463  -----FHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLS-DLESVDPELHKSLVWI 516

Query: 3754 FESINDETEL--EALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILV 3811
             E  ND T +     C E  +     +    PN                     GR++ V
Sbjct: 517  LE--NDITPVLDHTFCVEHNAFGRILQHELKPN---------------------GRNVPV 553

Query: 3812 AWENKDIYAAAIRSLRLRELQNVEC-VTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPY 3870
              ENK  Y     + R   ++ +E    A++ G   +IP  LL      E+EL   GL  
Sbjct: 554  TEENKKEYVRLYVNWRF--MRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDK 611

Query: 3871 INLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIPFTCPCKDG 3930
            I+L   K++T  +  + +++  + +FW A+E F +E   + ++F     R+P     K  
Sbjct: 612  IDLNDWKSNTRLKHCVADSNI-VRWFWQAVETFDEERRARLLQFVTGSTRVPLQ-GFKAL 669

Query: 3931 GPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
               T    P    I   D           +  TC   I +P Y S E + EKL  A+
Sbjct: 670  QGSTGAAGPRLFTIHLIDANT----DNLPKAHTCFNRIDIPPYESYEKLYEKLLTAV 722


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score = 70.1 bits (170), Expect = 4e-11
 Identities = 101/450 (22%), Positives = 179/450 (39%), Gaps = 56/450 (12%)

Query: 3555 KGLIFYDTKVTVMNRVLNATVQRTADHAAPEITLDPLEIVGGEIRASENSYFCQAARQL- 3613
            K L F +T  TV+N++L  +    AD     + +D + ++  +++     YF Q   +L 
Sbjct: 3954 KFLRFAETHRTVLNQILRQSTTHLADGPFA-VLVDYIRVLDFDVK---RKYFRQELERLD 4009

Query: 3614 ASVPSSQLCVKLA---------------SGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQV 3658
              +    + V +                S  +      I F GEE     G  R +   +
Sbjct: 4010 EGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMII 4069

Query: 3659 CKELQSSSLSLLLLCPSSAVNKNKGKYILTPSP-ITYGEEQLLHFLGQLLGIAIRADVPL 3717
             +E+ +   +L    P   V      Y + PS            F+G+++  A+  +  L
Sbjct: 4070 SREMFNPMYALFRTSPGDRVT-----YTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLL 4124

Query: 3718 PLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDETELEALCAEIASQHLAT 3777
                  SF+K ++G+ +    D++  D   Y++ +    +  E ++  L  ++      T
Sbjct: 4125 ECYFTRSFYKHILGKSVR-YTDMESED---YHFYQGLVYLL-ENDVSTLGYDL------T 4173

Query: 3778 ESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECV 3837
             S +      C         E  +L   G +ILV  ENK  Y   +  +R+      + +
Sbjct: 4174 FSTEVQEFGVC---------EVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQ-L 4223

Query: 3838 TAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIEFFW 3897
             A   G   IIP +L+++ +  E+EL   GLP I+++ LK++T Y      + Q I++FW
Sbjct: 4224 AAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQ-IQWFW 4282

Query: 3898 GALEMFTQEELCKFIKFACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGSPDSR 3957
             AL  F Q +  KF++F     ++P        G +         +I   D +      R
Sbjct: 4283 RALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQ----KFQIHRDDRST----DR 4334

Query: 3958 YIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
                 TC   + LP Y S E +   L  AI
Sbjct: 4335 LPSAHTCFNQLDLPAYESFEKLRHMLLLAI 4364


>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
          Length = 1068

 Score = 70.1 bits (170), Expect = 4e-11
 Identities = 94/369 (25%), Positives = 144/369 (39%), Gaps = 68/369 (18%)

Query: 3649 GSFRHFLWQVCKELQSSSLSLLLLCPSSAVNKNKGKYILTPSPITYGEE---QLLHFLGQ 3705
            G F+ FL ++ K +   +L+L             G   L PSP +Y  E   QL  F+G+
Sbjct: 729  GVFKEFLEEIIKRVFDPALNLF--------KTTSGDERLYPSPTSYIHENYLQLFEFVGK 780

Query: 3706 LLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDE----- 3760
            +LG A+   + + +     F   L+G              + Y+ V +  S++ E     
Sbjct: 781  MLGKAVYEGIVVDVPFASFFLSQLLGHHHS----------VFYSSVDELPSLDSEFYKNL 830

Query: 3761 TELEALCAEIASQHLATE-SPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIY 3819
            T ++    +I    L      D   +  C            EL   G+ I V  ENK  Y
Sbjct: 831  TSIKRYDGDITDLGLTLSYDEDVMGQLVCH-----------ELIPGGKTIPVTNENKISY 879

Query: 3820 AAAIRSLRLRELQNVECVTAVRAGLGSIIPLQLLTMLSPLEMELRTCG-LPYINLEFLKA 3878
               +   R+   Q      A+ +G  SII  + + M S  E++    G    I+LE LK 
Sbjct: 880  IHLMAHFRMHT-QIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKK 938

Query: 3879 HTMYQVGLMETDQHIEFFWGALEM-FTQEELCKFIKFACNQERIPFTCPCKDGGPDTAHV 3937
            HT+Y  G   + + I + W  L   FT +E   F+KF  +  R P            A++
Sbjct: 939  HTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLL--------GFAYL 990

Query: 3938 -PPYPMKIAPPDG------TAGS------------PDSRYIRVETCMFMIKLPQYSSLEI 3978
             PP+ ++            T GS            P  R     TC  ++KLP YS   +
Sbjct: 991  KPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSV 1050

Query: 3979 MLEKLRCAI 3987
            + EKLR AI
Sbjct: 1051 LREKLRYAI 1059


>gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
          Length = 1068

 Score = 70.1 bits (170), Expect = 4e-11
 Identities = 94/369 (25%), Positives = 144/369 (39%), Gaps = 68/369 (18%)

Query: 3649 GSFRHFLWQVCKELQSSSLSLLLLCPSSAVNKNKGKYILTPSPITYGEE---QLLHFLGQ 3705
            G F+ FL ++ K +   +L+L             G   L PSP +Y  E   QL  F+G+
Sbjct: 729  GVFKEFLEEIIKRVFDPALNLF--------KTTSGDERLYPSPTSYIHENYLQLFEFVGK 780

Query: 3706 LLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDE----- 3760
            +LG A+   + + +     F   L+G              + Y+ V +  S++ E     
Sbjct: 781  MLGKAVYEGIVVDVPFASFFLSQLLGHHHS----------VFYSSVDELPSLDSEFYKNL 830

Query: 3761 TELEALCAEIASQHLATE-SPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIY 3819
            T ++    +I    L      D   +  C            EL   G+ I V  ENK  Y
Sbjct: 831  TSIKRYDGDITDLGLTLSYDEDVMGQLVCH-----------ELIPGGKTIPVTNENKISY 879

Query: 3820 AAAIRSLRLRELQNVECVTAVRAGLGSIIPLQLLTMLSPLEMELRTCG-LPYINLEFLKA 3878
               +   R+   Q      A+ +G  SII  + + M S  E++    G    I+LE LK 
Sbjct: 880  IHLMAHFRMHT-QIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKK 938

Query: 3879 HTMYQVGLMETDQHIEFFWGALEM-FTQEELCKFIKFACNQERIPFTCPCKDGGPDTAHV 3937
            HT+Y  G   + + I + W  L   FT +E   F+KF  +  R P            A++
Sbjct: 939  HTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLL--------GFAYL 990

Query: 3938 -PPYPMKIAPPDG------TAGS------------PDSRYIRVETCMFMIKLPQYSSLEI 3978
             PP+ ++            T GS            P  R     TC  ++KLP YS   +
Sbjct: 991  KPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSV 1050

Query: 3979 MLEKLRCAI 3987
            + EKLR AI
Sbjct: 1051 LREKLRYAI 1059


>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
            sapiens]
          Length = 748

 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 95/410 (23%), Positives = 155/410 (37%), Gaps = 85/410 (20%)

Query: 3598 IRASENSYFCQAARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQ 3657
            I  S    F ++ RQ+  +    L  +L           I+F GEE     G  R +L+ 
Sbjct: 395  IEVSREEIFEESYRQVMKMRPKDLWKRLM----------IKFRGEEGLDYGGVAREWLYL 444

Query: 3658 VCKELQSSSLSL----------LLLCPSSAVNKNKGKYILTPSPITYGEEQLLHFLGQLL 3707
            +  E+ +    L          L + P SAVN         P  ++Y      HF+G+++
Sbjct: 445  LSHEMLNPYYGLFQYSRDDIYTLQINPDSAVN---------PEHLSY-----FHFVGRIM 490

Query: 3708 GIAIRADVPLPLDLLPSFWKTLVGEPLD-PEQDLQEADI---LTYNYVKKFESINDETEL 3763
            G+A+     +       F+K L+G+ +   + +L + D+   L +        + D T  
Sbjct: 491  GMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHT-- 548

Query: 3764 EALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAAAI 3823
               C E  +     +    PN                     G+ I V  ENK  Y    
Sbjct: 549  --FCVEHNAYGEIIQHELKPN---------------------GKSIPVNEENKKEYVRLY 585

Query: 3824 RSLRLRELQNVEC-VTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHTMY 3882
             + R   L+ +E    A++ G   +IP  LL      E+EL  CGL  I++   K +T  
Sbjct: 586  VNWRF--LRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRL 643

Query: 3883 QVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCKDGGPD--TAHV 3937
            +    +++  +++FW A+E F +E   + ++F     R+P   F       GP   T H 
Sbjct: 644  KHCTPDSNI-VKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQ 702

Query: 3938 PPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
                    P             +  TC   I +P Y S E + EKL  AI
Sbjct: 703  IDACTNNLP-------------KAHTCFNRIDIPPYESYEKLYEKLLTAI 739


>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
            ligase 2 [Homo sapiens]
          Length = 1572

 Score = 63.5 bits (153), Expect = 4e-09
 Identities = 82/354 (23%), Positives = 131/354 (37%), Gaps = 41/354 (11%)

Query: 3637 IRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSSAVNKNKGKYILTPSPITYGE 3696
            + F GEE    SG  R F + V +EL +    L       + N      I   S      
Sbjct: 1248 VTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLF----EYSANDTYTVQISPMSAFVDNH 1303

Query: 3697 EQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFES 3756
             +   F G++LG+A+     L       F+K L    L    DL + + L   + +  + 
Sbjct: 1304 HEWFRFSGRILGLALIHQYLLDAFFTRPFYKAL----LRILCDLSDLEYLDEEFHQSLQW 1359

Query: 3757 INDETELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENK 3816
            + D    + L                       F  +T    E EL   G +I V  +NK
Sbjct: 1360 MKDNDIHDILDLTFTVNEEV-------------FGQIT----ERELKPGGANIPVTEKNK 1402

Query: 3817 DIYAAAIRSLRLRELQNVECVTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFL 3876
              Y   +   R+ E   V+   ++  G   ++  +L+++    E+EL   G   I+L   
Sbjct: 1403 KEYIERMVKWRI-ERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDW 1461

Query: 3877 KAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCKDGGPD 3933
            + +T Y+ G  +    I +FW A+E F  E+  + ++F      IP   F       GP 
Sbjct: 1462 RNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPR 1521

Query: 3934 TAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
               V  +    A P            R  TC   + LP Y S  ++ EKL  A+
Sbjct: 1522 RFCVEKWGKITALP------------RAHTCFNRLDLPPYPSFSMLYEKLLTAV 1563


>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
          Length = 823

 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 53/189 (28%), Positives = 78/189 (41%), Gaps = 16/189 (8%)

Query: 3800 VELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECVTAVRAGLGSIIPLQLLTMLSPL 3859
            VEL + G    V   NK  Y   +   RL   Q  E V     GL  ++P  LL +    
Sbjct: 640  VELMTGGAQTPVTNANKIFYLNLLAQYRLAS-QVKEEVEHFLKGLNELVPENLLAIFDEN 698

Query: 3860 EMELRTCGLPYINLEFLKAHTMYQVGLME-TDQHIEFFWGALEMFTQEELCKFIKFACNQ 3918
            E+EL  CG   I++   KAH +   G     ++ + +FW  +   TQEEL + ++F    
Sbjct: 699  ELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFTTGS 758

Query: 3919 ERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEI 3978
             ++P        G   A  P + +  AP   T  +         TC   + LP Y S E 
Sbjct: 759  SQLP-------PGGFAALCPSFQIIAAPTHSTLPT-------AHTCFNQLCLPTYDSYEE 804

Query: 3979 MLEKLRCAI 3987
            +   L+ AI
Sbjct: 805  VHRMLQLAI 813


>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
          Length = 862

 Score = 60.1 bits (144), Expect = 4e-08
 Identities = 85/361 (23%), Positives = 137/361 (37%), Gaps = 51/361 (14%)

Query: 3639 FTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSSAVNKNKGKYILTPSPITYGEEQ 3698
            F GEE     G  R + + +  E+ +    L            K  Y L  +P +Y    
Sbjct: 540  FPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYA-------GKDNYCLQINPASYINPD 592

Query: 3699 LL---HFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFE 3755
             L    F+G+ + +A+     +       F+K ++ +P+  + DL+  D   YN +   +
Sbjct: 593  HLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLK-DLESIDPEFYNSLIWVK 651

Query: 3756 SIN-DETELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWE 3814
              N +E +LE   +    + +  E      KP                   G +ILV  E
Sbjct: 652  ENNIEECDLEMYFS--VDKEILGEIKSHDLKP------------------NGGNILVTEE 691

Query: 3815 NKDIYAAAIRSLRLRELQNVECVT-AVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINL 3873
            NK+ Y   +   RL   + VE  T A   G   I+P Q L      E+E+  CG+  I+L
Sbjct: 692  NKEEYIRMVAEWRLS--RGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDL 749

Query: 3874 EFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCKDG 3930
               + H +Y+     T + I +FW  ++    E+  + ++F     R+P   F       
Sbjct: 750  NDWQRHAIYR-HYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN 808

Query: 3931 GPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAIHYR 3990
            GP    +     +   P            R  TC   + LP Y S E + EKL  AI   
Sbjct: 809  GPQKFCIEKVGKENWLP------------RSHTCFNRLDLPPYKSYEQLKEKLLFAIEET 856

Query: 3991 E 3991
            E
Sbjct: 857  E 857


>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
          Length = 1606

 Score = 60.1 bits (144), Expect = 4e-08
 Identities = 78/354 (22%), Positives = 131/354 (37%), Gaps = 41/354 (11%)

Query: 3637 IRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSSAVNKNKGKYILTPSPITYGE 3696
            + F GEE    SG  R F + + +EL +    L       + N      I   S      
Sbjct: 1282 VTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLF----EYSANDTYTVQISPMSAFVENH 1337

Query: 3697 EQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFES 3756
             +   F G++LG+A+     L       F+K L+  P D    L + + L   + +  + 
Sbjct: 1338 LEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCD----LSDLEYLDEEFHQSLQW 1393

Query: 3757 INDETELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENK 3816
            + D    + L                       F  +T    E EL S G +  V  +NK
Sbjct: 1394 MKDNNITDILDLTFTVNEEV-------------FGQVT----ERELKSGGANTQVTEKNK 1436

Query: 3817 DIYAAAIRSLRLRELQNVECVTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFL 3876
              Y   +   R+ E   V+   A+  G   ++  +L+++    E+EL   G   I+L   
Sbjct: 1437 KEYIERMVKWRV-ERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDW 1495

Query: 3877 KAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIP---FTCPCKDGGPD 3933
            + +T Y+ G  +    I +FW A+E F  E+  + ++F      +P   F       G  
Sbjct: 1496 RNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLR 1555

Query: 3934 TAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAI 3987
               +  +    + P            R  TC   + LP Y S  ++ EKL  A+
Sbjct: 1556 RFCIEKWGKITSLP------------RAHTCFNRLDLPPYPSYSMLYEKLLTAV 1597


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 76/350 (21%), Positives = 128/350 (36%), Gaps = 44/350 (12%)

Query: 3639 FTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSSAVNKNKGKYILTPSPITYGEEQ 3698
            F GEE     G  + F   + KEL +    +      S         +L  S   + E  
Sbjct: 735  FDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSN--------LLWFSDTCFVEHN 786

Query: 3699 LLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESIN 3758
              H +G   G+AI     + L    + +K L+      E DL+E        +++     
Sbjct: 787  WFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLE-DLKELSPTEGRSLQELLDYP 845

Query: 3759 DETELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDI 3818
             E   E  C                N   CR +Y  +  E+ +L   G ++ V  +N+  
Sbjct: 846  GEDVEETFCL---------------NFTICRESYGVI--EQKKLIPGGDNVTVCKDNRQE 888

Query: 3819 YAAAIRSLRLRELQNVECVTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKA 3878
            +  A  +  + ++   E  TA  +G   +   ++L +  P E+     G    N E L+ 
Sbjct: 889  FVDAYVNY-VFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEE 947

Query: 3879 HTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIPFTCPCKDGGPDTAHVP 3938
              +Y+     T   ++ FW     F  E+  KF+ F    +RIP                
Sbjct: 948  TAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPI--------------- 992

Query: 3939 PYPMKIAPPDGTAGSPDSRYIRV-ETCMFMIKLPQYSSLEIMLEKLRCAI 3987
             Y M        + +    Y+ V  TC  ++ LP+YSS EI+  +L  A+
Sbjct: 993  -YGMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQAL 1041


>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [Homo
            sapiens]
          Length = 922

 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 52/187 (27%), Positives = 77/187 (41%), Gaps = 13/187 (6%)

Query: 3806 GRHILVAWENKDIYAAAIRSLRL-RELQNVECVTAVRAGLGSIIPLQLLTMLSPLEMELR 3864
            G +ILV  ENKD Y   +   R  R +Q  E   A   G   ++PLQ L      E+E+ 
Sbjct: 743  GSNILVTEENKDEYIGLMTEWRFSRGVQ--EQTKAFLDGFNEVVPLQWLQYFDEKELEVM 800

Query: 3865 TCGLPYINLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIPFT 3924
             CG+  ++L   + +T+Y+       + I +FW  ++    E   + ++F     R+P  
Sbjct: 801  LCGMQEVDLADWQRNTVYR-HYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPL- 858

Query: 3925 CPCKDGGPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLR 3984
                 GG         P K           D+   R  TC   + LP Y S E + EKL 
Sbjct: 859  -----GGFAELMGSNGPQKFCI---EKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLL 910

Query: 3985 CAIHYRE 3991
             AI   E
Sbjct: 911  FAIEETE 917


>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
            isoform 2 [Homo sapiens]
          Length = 431

 Score = 53.5 bits (127), Expect = 4e-06
 Identities = 51/195 (26%), Positives = 78/195 (40%), Gaps = 19/195 (9%)

Query: 3801 ELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECVT-AVRAGLGSIIPLQLLTMLSPL 3859
            EL   G  I V  ENK+ Y   +   R    + VE  T A   G   + PL+ L      
Sbjct: 247  ELKEGGESIRVTEENKEEYIMLLTDWRFT--RGVEEQTKAFLDGFNEVAPLEWLRYFDEK 304

Query: 3860 EMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQE 3919
            E+EL  CG+  I++   +  T+Y+    +  + I++FW  ++    E+  + ++F     
Sbjct: 305  ELELMLCGMQEIDMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTC 363

Query: 3920 RIP---FTCPCKDGGPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSL 3976
            R+P   F       GP    +     +   P            R  TC   + LP Y S 
Sbjct: 364  RLPVGGFAELIGSNGPQKFCIDKVGKETWLP------------RSHTCFNRLDLPPYKSY 411

Query: 3977 EIMLEKLRCAIHYRE 3991
            E + EKL  AI   E
Sbjct: 412  EQLREKLLYAIEETE 426


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 159,423,647
Number of Sequences: 37866
Number of extensions: 7672754
Number of successful extensions: 32457
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 30720
Number of HSP's gapped (non-prelim): 1427
length of query: 3996
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3874
effective length of database: 13,627,866
effective search space: 52794352884
effective search space used: 52794352884
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.