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Search of human proteins with 157739945
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157739945 tetratricopeptide repeat, ankyrin repeat and
coiled-coil containing 2 [Homo sapiens]
(1990 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 3964 0.0
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 1719 0.0
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 1638 0.0
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 329 1e-89
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 172 3e-42
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 172 3e-42
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 164 6e-40
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 164 6e-40
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 159 2e-38
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 159 2e-38
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 159 2e-38
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 150 2e-35
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 148 5e-35
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 148 5e-35
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 147 8e-35
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 147 8e-35
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 147 8e-35
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 147 8e-35
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 147 8e-35
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 142 4e-33
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 140 2e-32
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 136 2e-31
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 135 4e-31
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 133 2e-30
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 124 1e-27
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 123 2e-27
gi|34304381 inversin isoform a [Homo sapiens] 120 2e-26
gi|34304379 inversin isoform b [Homo sapiens] 120 2e-26
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 117 9e-26
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 115 6e-25
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 3964 bits (10281), Expect = 0.0
Identities = 1990/1990 (100%), Positives = 1990/1990 (100%)
Query: 1 MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPD 60
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPD
Sbjct: 1 MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPD 60
Query: 61 YAVPPLPVSEGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYSMEVQDENQ 120
YAVPPLPVSEGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYSMEVQDENQ
Sbjct: 61 YAVPPLPVSEGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYSMEVQDENQ 120
Query: 121 TSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG 180
TSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
Sbjct: 121 TSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG 180
Query: 181 IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLN 240
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLN
Sbjct: 181 IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLN 240
Query: 241 KIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQ 300
KIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQ
Sbjct: 241 KIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQ 300
Query: 301 SMGGARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNA 360
SMGGARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNA
Sbjct: 301 SMGGARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNA 360
Query: 361 SVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPP 420
SVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPP
Sbjct: 361 SVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPP 420
Query: 421 SAHSSITSGSCPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLC 480
SAHSSITSGSCPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLC
Sbjct: 421 SAHSSITSGSCPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLC 480
Query: 481 RSPQLTAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIIL 540
RSPQLTAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIIL
Sbjct: 481 RSPQLTAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIIL 540
Query: 541 IDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRL 600
IDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRL
Sbjct: 541 IDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRL 600
Query: 601 EENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLT 660
EENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLT
Sbjct: 601 EENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLT 660
Query: 661 FDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTD 720
FDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTD
Sbjct: 661 FDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTD 720
Query: 721 EHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKT 780
EHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKT
Sbjct: 721 EHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKT 780
Query: 781 KFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLW 840
KFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLW
Sbjct: 781 KFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLW 840
Query: 841 ISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEM 900
ISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEM
Sbjct: 841 ISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEM 900
Query: 901 VALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAAL 960
VALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAAL
Sbjct: 901 VALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAAL 960
Query: 961 RGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEE 1020
RGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEE
Sbjct: 961 RGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEE 1020
Query: 1021 VERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW 1080
VERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW
Sbjct: 1021 VERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW 1080
Query: 1081 QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWA 1140
QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWA
Sbjct: 1081 QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWA 1140
Query: 1141 CLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGM 1200
CLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGM
Sbjct: 1141 CLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGM 1200
Query: 1201 RPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKV 1260
RPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKV
Sbjct: 1201 RPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKV 1260
Query: 1261 KEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALEL 1320
KEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALEL
Sbjct: 1261 KEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALEL 1320
Query: 1321 KPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQPQQ 1380
KPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQPQQ
Sbjct: 1321 KPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQPQQ 1380
Query: 1381 PPPPPQPQQQLPEEAEPEPQHEDIYSVQDIFEEEYLEQDVENVSIGLQTEARPSQGLPVI 1440
PPPPPQPQQQLPEEAEPEPQHEDIYSVQDIFEEEYLEQDVENVSIGLQTEARPSQGLPVI
Sbjct: 1381 PPPPPQPQQQLPEEAEPEPQHEDIYSVQDIFEEEYLEQDVENVSIGLQTEARPSQGLPVI 1440
Query: 1441 QSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQNSHYRP 1500
QSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQNSHYRP
Sbjct: 1441 QSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQNSHYRP 1500
Query: 1501 SPPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGS 1560
SPPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGS
Sbjct: 1501 SPPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGS 1560
Query: 1561 PVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGLRLQPAKAQIVRSNQPSP 1620
PVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGLRLQPAKAQIVRSNQPSP
Sbjct: 1561 PVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGLRLQPAKAQIVRSNQPSP 1620
Query: 1621 AVHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQSRLVYQGSIGGIVGDGRPVQHVQAS 1680
AVHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQSRLVYQGSIGGIVGDGRPVQHVQAS
Sbjct: 1621 AVHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQSRLVYQGSIGGIVGDGRPVQHVQAS 1680
Query: 1681 LSAGAICQHGGLTKEDLPQRPSSAYRGGVRYSQTPQIGRSQSASYYPVCHSKLDLERSSS 1740
LSAGAICQHGGLTKEDLPQRPSSAYRGGVRYSQTPQIGRSQSASYYPVCHSKLDLERSSS
Sbjct: 1681 LSAGAICQHGGLTKEDLPQRPSSAYRGGVRYSQTPQIGRSQSASYYPVCHSKLDLERSSS 1740
Query: 1741 QLGSPDVSHLIRRPISVNPNEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSTSNLTPTFR 1800
QLGSPDVSHLIRRPISVNPNEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSTSNLTPTFR
Sbjct: 1741 QLGSPDVSHLIRRPISVNPNEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSTSNLTPTFR 1800
Query: 1801 PSSSIQQMEIPLKPAYERSCDELSPVSPTQGGYPSEPTRSRTTPFMGIIDKTARTQQYPH 1860
PSSSIQQMEIPLKPAYERSCDELSPVSPTQGGYPSEPTRSRTTPFMGIIDKTARTQQYPH
Sbjct: 1801 PSSSIQQMEIPLKPAYERSCDELSPVSPTQGGYPSEPTRSRTTPFMGIIDKTARTQQYPH 1860
Query: 1861 LHQQNRTWAVSSVDTVLSPTSPGNLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYY 1920
LHQQNRTWAVSSVDTVLSPTSPGNLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYY
Sbjct: 1861 LHQQNRTWAVSSVDTVLSPTSPGNLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYY 1920
Query: 1921 SPHGMLANGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYRQLSRDSRQGQTSPIK 1980
SPHGMLANGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYRQLSRDSRQGQTSPIK
Sbjct: 1921 SPHGMLANGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYRQLSRDSRQGQTSPIK 1980
Query: 1981 PKRPFVESNV 1990
PKRPFVESNV
Sbjct: 1981 PKRPFVESNV 1990
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 1719 bits (4453), Expect = 0.0
Identities = 911/1511 (60%), Positives = 1116/1511 (73%), Gaps = 55/1511 (3%)
Query: 67 PVSEGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYSMEVQDENQT--SAI 124
P + E + PS AA L+TRLGFLLGE + + ++D+N+T +A+
Sbjct: 115 PTEPDEHEAKADNEPSCSPAAQELLTRLGFLLGEGIPSAT-----HITIEDKNETMCTAL 169
Query: 125 TQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSGIIAT 184
+Q ISPCSTLTSSTASP SPCSTL + A ++SP+STLES+DSGIIAT
Sbjct: 170 SQGISPCSTLTSSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIAT 229
Query: 185 LTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPE 244
+TS SEN +R+ + E +K+ ++ D+C +E T S S E
Sbjct: 230 ITSSSENDDRSGSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAE 289
Query: 245 RNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGG 304
+ Q +MPRPNSVAATSS LEDL+YLD QR+ PLRTS+R+P + G
Sbjct: 290 SSAGDGPVPYSQGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAG 349
Query: 305 ARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQ 364
R Q+ ++ RFAPY+P DI LKPLLFEVPSITT+SVFVGRDW+FH+I+ L+++ + N+
Sbjct: 350 GRAQE-VKARFAPYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENR 408
Query: 365 GVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHS 424
G V+VGN+GFGKTAIIS+LVALSCHG+RMRQIAS+SP +SPK D ++L T S S
Sbjct: 409 GAVVVGNVGFGKTAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSS 468
Query: 425 SITSGSCPGTP------EMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAAL 478
S ++ S TP E +R +E+A++ LAS+VVAYHYCQADN YTCLVPEFVH++AAL
Sbjct: 469 STSASSTAKTPLGSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAAL 528
Query: 479 LCRSPQLTAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFI 538
LCRS QL AYR+ L++EP LQSMLSLRSCVQDP+A+F+RGVLEPL NL E+KIP+E++I
Sbjct: 529 LCRSHQLAAYRDLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYI 588
Query: 539 ILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLD 598
ILIDGLNEAEFHKPDYGDT+ SF++K+I KFP+WLKLIVTVR + QEI LPF ++ LD
Sbjct: 589 ILIDGLNEAEFHKPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLD 648
Query: 599 RLEENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLK 658
+N+ I DL AY+ HR+HSS +I +NISLNGK D T GK+SSHL S GSYLYLK
Sbjct: 649 DFPDNKDIHSDLHAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLK 708
Query: 659 LTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPL 718
LT DL ++G+LV+KS+SYKVVPVSLSE+YLLQCNMKF TQS+F+R +P+LNVA+ASLHP+
Sbjct: 709 LTLDLFQRGHLVIKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPM 768
Query: 719 TDEHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGE 778
TDE IFQAINAG I+G WEDFQQRM+ LS FLIKRRD TRMF HPSFREWL+WR +GE
Sbjct: 769 TDEQIFQAINAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGE 828
Query: 779 KTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQG 838
T FLC+PR+GH LLAF FSRQEGKLNRQQT+ELGHHILKAHIFKGLSKK G+SSS LQ
Sbjct: 829 NTAFLCEPRNGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQA 888
Query: 839 LWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYT 898
LWI YSTEGLS ALASLRNLYTPN+KVSRLLILGGAN+NYRTEVLNNAPILCVQSHLG+
Sbjct: 889 LWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHE 948
Query: 899 EMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHA 958
E+V LLLEFGA +D +SE+G+T L YAAAAG++ +V LL KK +VDHLDK GQCALVH+
Sbjct: 949 EVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHS 1008
Query: 959 ALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDE 1018
ALRGH +++++L+ C+W+ Q G +KSHA+QQAL AAASMG++ +V LL + ++ E
Sbjct: 1009 ALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHE 1068
Query: 1019 EEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQG 1078
EV N D+LWGETALTAAAGRGKLEVC LLL GAAV++ NRRG PLF RQG
Sbjct: 1069 VEV-----NGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQG 1123
Query: 1079 HWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALS 1138
HWQIV LLL G DVN++DKQGRTPLM+AA EGHL TV+FLL++GA+++ +DKEGL+ALS
Sbjct: 1124 HWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALS 1183
Query: 1139 WACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYS 1198
WACLKGH +VV+ LV+ GAA D DKNGRTPLDLAAFYGDAE V +LV+ GA+IEHVD+S
Sbjct: 1184 WACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHS 1243
Query: 1199 GMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKG 1258
GMRPLDRA+GCRNTSVVV LL+KGAK+G A WAMATSKPDI+IILL KLMEEG++ YKKG
Sbjct: 1244 GMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKG 1303
Query: 1259 KVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKAL 1318
K+KEAAQRYQYAL+KFPREGFGED++ F EL+VSL LNLSRCRRK NDFGMAEEFA+KAL
Sbjct: 1304 KMKEAAQRYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKAL 1363
Query: 1319 ELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQM--- 1375
ELKPKSYEA+YARARAKR+SRQF AAL DL EA+KLCP N+E++RLL RVEEEC+Q+
Sbjct: 1364 ELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQRS 1423
Query: 1376 -QQPQQPPPPPQPQQQLPEEAEPEPQHEDIYSVQDIFEEEYLEQDVENVSIGLQTEARPS 1434
QQ QQ P P EE P P D + ++ EEE Q+ E+VS
Sbjct: 1424 QQQKQQGPLPAPLNDSENEEDTPTPGLSDHFHSEETEEEETSPQE-ESVS---------- 1472
Query: 1435 QGLPVIQSPPSSPPHRDSAYISSSPLG---SHQVFDFRSSSSVGSPTRQTYQSTSPALSP 1491
P +S PSS S+YI + G + +S + +G R+ L P
Sbjct: 1473 ---PTPRSQPSSSV--PSSYIRNLQEGLQSKGRPVSPQSRAGIGKSLREPVAQPGLLLQP 1527
Query: 1492 THQNSHYRPSPPHTS--PAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAE 1549
+ Q + S S A + GS + + Q +PPPSP+ P A+ PA
Sbjct: 1528 SKQAQIVKTSQHLGSGQSAVRNGSMKVQ---ISSQ-----NPPPSPM---PGRIAATPAG 1576
Query: 1550 SMSVYRSQSGS 1560
S + + +G+
Sbjct: 1577 SRTQHLEGTGT 1587
Score = 71.2 bits (173), Expect = 9e-12
Identities = 113/490 (23%), Positives = 188/490 (38%), Gaps = 67/490 (13%)
Query: 1507 PAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQ 1566
PA S P G + S PQ + P S S +R Q
Sbjct: 1433 PAPLNDSENEEDTPTPGLSDHFHSEETEEEETSPQEESVSPTPRSQPSSSVPSSYIRNLQ 1492
Query: 1567 ETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGLRLQPAK-AQIVRSNQPSPAVHSS 1625
E S+ GRP SP S+ L V Q GL LQP+K AQIV+++Q + S+
Sbjct: 1493 EGLQSK--GRPVSPQSRAGIGK----SLREPVAQPGLLLQPSKQAQIVKTSQHLGSGQSA 1546
Query: 1626 TVIPTGAYGQVAHSMASKYQSSQGDIGVSQSRLVYQGSIGGIVGDGRPVQHVQAS--LSA 1683
+ G+ S G I + + G QH++ + +
Sbjct: 1547 --VRNGSMKVQISSQNPPPSPMPGRIAATPA--------------GSRTQHLEGTGTFTT 1590
Query: 1684 GAICQHGGLTKEDLPQRPSSAYRGGVRYSQTPQIGRSQSASYYPVCHSKLDLERSSSQLG 1743
A C H G + L + + G P ++++ + HS + ++ + G
Sbjct: 1591 RAGCGHFG---DRLGPSQNVRLQCGENGPAHPLPSKTKTTERL-LSHSSVAVDAAPPNQG 1646
Query: 1744 SPDVSHLIRRPISVNPNEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSTSNLTPTFRPSS 1803
+R P S+ + P S ++ S S++S++S+S+ + F+
Sbjct: 1647 GLATCSDVRHPASLTSSGSSGSP----------SSSIKMSSSTSSLTSSSSFSDGFK--- 1693
Query: 1804 SIQQMEIPLKPAYERSCDELSPVSPTQGGYPSEPTRSRTTPFMGIIDKTARTQQYPHLHQ 1863
+Q + +K V+ Q G R R TPFMGI+DKTAR QQ +
Sbjct: 1694 -VQGPDTRIKDKV---------VTHVQSGTAEH--RPRNTPFMGIMDKTARFQQ--QSNP 1739
Query: 1864 QNRTWAVSSVDTVLSPTSPGNLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYYSPH 1923
+R+W + + +L+ TS Q + PS + + N+ L
Sbjct: 1740 PSRSWHCPAPEGLLTNTSSAAGLQSANTEKPSLMQVGGYNNQAKTCSVSTL--------S 1791
Query: 1924 GMLANGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYRQ---LSRDSRQGQTSPIK 1980
+ NG++ LE + T V+ YQ+++ +Q +S ++ + + K
Sbjct: 1792 ASVHNGAQVKELEESKCQIPVHSQENRITKTVSHLYQESISKQQPHISNEAHRSHLTAAK 1851
Query: 1981 PKRPFVESNV 1990
PKR F+ESNV
Sbjct: 1852 PKRSFIESNV 1861
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 1638 bits (4242), Expect = 0.0
Identities = 849/1334 (63%), Positives = 1024/1334 (76%), Gaps = 46/1334 (3%)
Query: 16 SRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEP--DYAVPPLPVSEGDA 73
SR N+ S G P R+ V+S + D P + A P P A
Sbjct: 79 SRVNKKSPG-----PVRKPKYVESPR---------VPGDAVIMPFREVAKPTEPDEHAKA 124
Query: 74 EQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYSMEVQDENQT--SAITQRISPC 131
+ E PS AA L+TRLGFLLGE + + ++D+N+T +A++Q ISPC
Sbjct: 125 DNE----PSCSPAAQELLTRLGFLLGEGIPSAT-----HITIEDKNETMCTALSQGISPC 175
Query: 132 STLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSGIIATLTSYSEN 191
STLTSSTASP SPCSTL + A ++SP+STLES+DSGIIAT+TS SEN
Sbjct: 176 STLTSSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSEN 235
Query: 192 VERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVL 251
+R+ + E +K+ ++ D+C +E T S S E +
Sbjct: 236 DDRSGSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGP 295
Query: 252 SQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDL 311
Q +MPRPNSVAATSS LEDL+YLD QR+ PLRTS+R+P + GAR
Sbjct: 296 VPYSQGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAGAR----- 350
Query: 312 RVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGN 371
FAPY+P DI LKPLLFEVPSITT+SVFVGRDW+FH+I+ L+++ + N+G V+VGN
Sbjct: 351 ---FAPYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGN 407
Query: 372 IGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGSC 431
+GFGKTAIIS+LVALSCHG+RMRQIAS+SP +SPK D ++L T S SS ++ S
Sbjct: 408 VGFGKTAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASST 467
Query: 432 PGTP------EMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQL 485
TP E +R +E+A++ LAS+VVAYHYCQADN YTCLVPEFVH++AALLCRS QL
Sbjct: 468 AKTPLGSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQL 527
Query: 486 TAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLN 545
AYR+ L++EP LQSMLSLRSCVQDP+A+F+RGVLEPL NL E+KIP+E++IILIDGLN
Sbjct: 528 AAYRDLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLN 587
Query: 546 EAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEA 605
EAEFHKPDYGDT+ SF++K+I KFP+WLKLIVTVR + QEI LPF ++ LD +N+
Sbjct: 588 EAEFHKPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKD 647
Query: 606 IDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIE 665
I DL AY+ HR+HSS +I +NISLNGK D T GK+SSHL S GSYLYLKLT DL +
Sbjct: 648 IHSDLHAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQ 707
Query: 666 KGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQ 725
+G+LV+KS+SYKVVPVSLSE+YLLQCNMKF TQS+F+R +P+LNVA+ASLHP+TDE IFQ
Sbjct: 708 RGHLVIKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQ 767
Query: 726 AINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCD 785
AINAG I+G WEDFQQRM+ LS FLIKRRD TRMF HPSFREWL+WR +GE T FLC+
Sbjct: 768 AINAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCE 827
Query: 786 PRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYST 845
PR+GH LLAF FSRQEGKLNRQQT+ELGHHILKAHIFKGLSKK G+SSS LQ LWI YST
Sbjct: 828 PRNGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYST 887
Query: 846 EGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLL 905
EGLS ALASLRNLYTPN+KVSRLLILGGAN+NYRTEVLNNAPILCVQSHLG+ E+V LLL
Sbjct: 888 EGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLL 947
Query: 906 EFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLE 965
EFGA +D +SE+G+T L YAAAAG++ +V LL KK +VDHLDK GQCALVH+ALRGH +
Sbjct: 948 EFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGD 1007
Query: 966 VVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQ 1025
++++L+ C+W+ Q G +KSHA+QQAL AAASMG++ +V LL + ++ E EV
Sbjct: 1008 ILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEV---- 1063
Query: 1026 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDL 1085
N D+LWGETALTAAAGRGKLEVC LLL GAAV++ NRRG PLF RQGHWQIV L
Sbjct: 1064 -NGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1122
Query: 1086 LLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGH 1145
LL G DVN++DKQGRTPLM+AA EGHL TV+FLL++GA+++ +DKEGL+ALSWACLKGH
Sbjct: 1123 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1182
Query: 1146 LSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDR 1205
+VV+ LV+ GAA D DKNGRTPLDLAAFYGDAE V +LV+ GA+IEHVD+SGMRPLDR
Sbjct: 1183 RAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDR 1242
Query: 1206 AVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQ 1265
A+GCRNTSVVV LL+KGAK+G A WAMATSKPDI+IILL KLMEEG++ YKKGK+KEAAQ
Sbjct: 1243 AIGCRNTSVVVALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQ 1302
Query: 1266 RYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSY 1325
RYQYAL+KFPREGFGED++ F EL+VSL LNLSRCRRK NDFGMAEEFA+KALELKPKSY
Sbjct: 1303 RYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSY 1362
Query: 1326 EAYYARARAKRSSR 1339
EA+YARARAKR+SR
Sbjct: 1363 EAFYARARAKRNSR 1376
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 329 bits (844), Expect = 1e-89
Identities = 273/954 (28%), Positives = 437/954 (45%), Gaps = 185/954 (19%)
Query: 341 FVGRDWVFHEIDAQLQSS----NASVNQ---------------------GVVIVGNIGFG 375
F R+WVFH++ LQ N++VN GV++VG G G
Sbjct: 23 FYCREWVFHKLQHCLQEKSNCCNSAVNAPSLVMNSGNNASGVSGKGAAWGVLLVGGPGSG 82
Query: 376 KTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGSCPGTP 435
KTA+ + L+ PS+ +S+ G
Sbjct: 83 KTALCTELLW----------------------------------PSSPASLQRG------ 102
Query: 436 EMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLRE 495
L Q +A+H+C+A ++ T V F+ + A +CRS L Y ++L R+
Sbjct: 103 ------------LHRQALAFHFCKAQDSDTLCVGGFIRGLVAQICRSGLLQGYEDKL-RD 149
Query: 496 PHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEA------EF 549
P +QS+L C ++P +F+R VL PL + K P + +L+D ++E E
Sbjct: 150 PAVQSLLQPGECERNPAEAFKRCVLLPLLGM----KPPQQSLYLLVDSVDEGCNITEGEQ 205
Query: 550 HKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLP-FHRIFLDRLEENEAIDQ 608
T+ + L+ FP WL L+ + R + +TK+ F +I LD L + + +
Sbjct: 206 TSTSLSGTVAALLAGHHEFFPPWLLLLCSARKQSKAVTKMFTGFRKISLDDLRKAYIV-K 264
Query: 609 DLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGY 668
D+Q YILHR+ ++ +++ ++ + L S G +LYL+ D + + +
Sbjct: 265 DVQQYILHRLDQEEALRQHLTKET-------AEMLNQLHIKSSGCFLYLERVLDGVVENF 317
Query: 669 LVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAIN 728
++L+ + +P +L+ +YL C F + F +V P+LNV +A+ PLT ++ A+
Sbjct: 318 IMLRE--IRDIPGTLNGLYLWLCQRLF-VRKQFAKVQPILNVILAACRPLTITELYHAVW 374
Query: 729 AGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCDPRS 788
++ TLE DFQ++++ LS L+ T++ H SF EWL+ + + K+LC+
Sbjct: 375 TKNMSLTLE--DFQRKLDILSKLLVDGLGNTKILFHYSFAEWLLDVKHCTQ-KYLCNAAE 431
Query: 789 GHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGL 848
GH +LA ++ Q L + E H++ +++ ++ + L +W
Sbjct: 432 GHRMLAMSYTCQAKNLTPLEAQEFALHLINSNL------QLETAELALWMIWNGTPVRD- 484
Query: 849 SMALASLRNLYTPNIKVSRLLILGGANINY---RTEVL---------------------- 883
SL L +V +LL+ GA++N RT +
Sbjct: 485 -----SLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVN 539
Query: 884 ----NNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCK 939
N +L ++ G ++V LL+ GA+++ G TPL AA G+ +V L
Sbjct: 540 QCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIG 599
Query: 940 KRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQC------------------------DW 975
A ++H D++G AL AA GH EVV L+ D
Sbjct: 600 CGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDI 659
Query: 976 TMAGQQQG--VFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLW 1033
+ Q G V K + + ALIAAA MG+ EIV +LLD A++N D +
Sbjct: 660 VLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLD---------HGAEVNHED-VD 709
Query: 1034 GETALTAAA-----GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLT 1088
G TAL+ AA +G V LL+++GA V ++ G PL +GH +VDLLL
Sbjct: 710 GRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769
Query: 1089 HGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSV 1148
GADV+ D GRTPL+ AAS GH V+ LL GA++ +D EG T LS A +G++ V
Sbjct: 770 GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829
Query: 1149 VRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRP 1202
VR+L+D G +H D G TPL +AAF G + + L++ GA +D G P
Sbjct: 830 VRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIP 883
Score = 169 bits (428), Expect = 2e-41
Identities = 126/403 (31%), Positives = 186/403 (46%), Gaps = 57/403 (14%)
Query: 859 YTPNIKVSRLLILGGANINYRT---EVLNNAPILCVQSHLGYTEMVALLLEFGANVDASS 915
Y + ++ L+ GA +N+ + LCV + G+ +V+LL++ GA VD
Sbjct: 686 YMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCD 745
Query: 916 ESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDW 975
+ G+TPL AA G++ +V LL + A VDH D NG+ L+ AA GH VV L+ W
Sbjct: 746 KDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLF--W 803
Query: 976 TMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLD--LPEKDEEEVERAQINSFDSLW 1033
A V + L A++ G E+V LLD L E ++
Sbjct: 804 GAA-----VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDA------------ 846
Query: 1034 GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQ------------ 1081
G T L AA G +C L+EQGA + + G +P ++GH+
Sbjct: 847 GWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNI 906
Query: 1082 ---------------------IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLL 1120
IV+LL +HGADVN D GR L + A E L ++ L
Sbjct: 907 DQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFL 966
Query: 1121 AQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAE 1180
GA++ D EG TAL +C +GH+ +V+ L+ A + AD R+ L AA+ G +
Sbjct: 967 ENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVK 1026
Query: 1181 VVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
VVQ L++HGA+++H G L A + VV LL+ GA
Sbjct: 1027 VVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGA 1069
Score = 151 bits (381), Expect = 7e-36
Identities = 113/365 (30%), Positives = 175/365 (47%), Gaps = 24/365 (6%)
Query: 869 LILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAA-- 926
L+ GA +N A L +++G+ E+V LL+ GA V+ G T L AA
Sbjct: 663 LLQHGAEVNKADNEGRTA--LIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC 720
Query: 927 ---AAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983
+ G+ S+V LL + A+VDH DK+G L+ AA GH++VV L++
Sbjct: 721 VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGG-------AD 773
Query: 984 VFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAG 1043
V + + L+AAASMG+ +V+ LL A ++S DS G T L+ A+
Sbjct: 774 VDHTDNNGRTPLLAAASMGHASVVNTLL---------FWGAAVDSIDSE-GRTVLSIASA 823
Query: 1044 RGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTP 1103
+G +EV R LL++G + G PL +GH I + L+ GA N D GR P
Sbjct: 824 QGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIP 883
Query: 1104 LMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHAD 1163
++A+ EGH V LL ++I +G AL A L+GH +V L +GA + D
Sbjct: 884 FILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKD 943
Query: 1164 KNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
+GR L + A + ++ +++GA +E D G L + + +V L+ A
Sbjct: 944 ADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA 1003
Query: 1224 KIGPA 1228
+ A
Sbjct: 1004 DVNAA 1008
Score = 127 bits (318), Expect = 1e-28
Identities = 79/207 (38%), Positives = 109/207 (52%), Gaps = 6/207 (2%)
Query: 1024 AQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIV 1083
A +N DS G T L AA G L+V LL+ +GA + + G PL RQGH ++V
Sbjct: 536 ASVNQCDSN-GRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVV 594
Query: 1084 DLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLK 1143
+ L+ GA++N D+ G T L AA GH V LL G + D + TAL A
Sbjct: 595 NCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWG 654
Query: 1144 GHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1203
GH +V +L+ +GA + AD GRT L AA+ G E+V+ L+DHGA + H D G L
Sbjct: 655 GHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTAL 714
Query: 1204 DRAVGC-----RNTSVVVTLLKKGAKI 1225
A C + SVV L+ +GA++
Sbjct: 715 SVAALCVPASKGHASVVSLLIDRGAEV 741
Score = 108 bits (271), Expect = 4e-23
Identities = 70/202 (34%), Positives = 103/202 (50%), Gaps = 3/202 (1%)
Query: 1024 AQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIV 1083
A +NS D T+ + + R LL+ GA+V Q + G L + G +V
Sbjct: 505 AHVNSEDD---RTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVV 561
Query: 1084 DLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLK 1143
+LL++ GAD+ + D G TPL +AA +GH V+ L+ GA+I D++G TAL A
Sbjct: 562 NLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWG 621
Query: 1144 GHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1203
GH VV +L+ G D AD + RT L AA+ G ++V L+ HGA + D G L
Sbjct: 622 GHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 681
Query: 1204 DRAVGCRNTSVVVTLLKKGAKI 1225
A + +V LL GA++
Sbjct: 682 IAAAYMGHREIVEHLLDHGAEV 703
Score = 108 bits (270), Expect = 5e-23
Identities = 90/319 (28%), Positives = 151/319 (47%), Gaps = 35/319 (10%)
Query: 865 VSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGY 924
V+ LL G A + +E +L + S G E+V LL+ G + + ++G TPL
Sbjct: 797 VNTLLFWGAAVDSIDSE---GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHM 853
Query: 925 AAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGV 984
AA G+ I L ++ A+ + +D +G+ + A+ GH + V+ L++ + +
Sbjct: 854 AAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE-------NKSNI 906
Query: 985 FKKSHAIQQALIAAASMGYTEIVSYLL----DLPEKD------------EEEVERAQ--- 1025
++ + + AL AA G+ +IV L D+ KD E ++ A+
Sbjct: 907 DQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFL 966
Query: 1026 -----INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW 1080
+ + D+ G TAL + +G +E+ ++L+ A V + L S QGH
Sbjct: 967 ENGANVEASDAE-GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHV 1025
Query: 1081 QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWA 1140
++V LL+ HGA V+ QG T L +AA EGH+ V LL GA D+ G TA+ A
Sbjct: 1026 KVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVA 1085
Query: 1141 CLKGHLSVVRSLVDNGAAT 1159
GH +++ L GA++
Sbjct: 1086 AKNGHSQIIKLLEKYGASS 1104
Score = 92.4 bits (228), Expect = 4e-18
Identities = 62/182 (34%), Positives = 95/182 (52%), Gaps = 4/182 (2%)
Query: 1048 EVCRLLLEQGAAV-AQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMM 1106
EV +LL++ GA V ++ +R + + R+ + LL +GA VN D GRT L
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALEREDS---IRTLLDNGASVNQCDSNGRTLLAN 551
Query: 1107 AASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNG 1166
AA G L V+ L+++GA + + D G T L+ A +GH VV L+ GA +H D++G
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
Query: 1167 RTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIG 1226
T L AA+ G EVV L+ G ++ D L A + +V+ LL+ GA++
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
Query: 1227 PA 1228
A
Sbjct: 672 KA 673
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 172 bits (436), Expect = 3e-42
Identities = 132/396 (33%), Positives = 199/396 (50%), Gaps = 54/396 (13%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
++K+ +LL+ A++N ++ N A L GY ++V +LLE GA+++ +E+G TP
Sbjct: 313 HVKIVKLLLAHKADVNAQSSTGNTA--LTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980
L A +AG++ + LL + A ++ H ++ + AL A +GHLE+V+FL++ AG
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE-----AGA 425
Query: 981 QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWGETALT 1039
Q K+ + AL+ A G+ E+ LLD AQ+N DS E+ LT
Sbjct: 426 DQE--HKTDEMHTALMEACMDGHVEVARLLLD---------SGAQVNMPADSF--ESPLT 472
Query: 1040 AAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQ 1099
AA G +E+ LL+E+GA++ + N G PL R+GH ++V LLL GA++N ++
Sbjct: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532
Query: 1100 GR-------------------------------TPLMMAASEGHLGTVDFLLAQGASIAL 1128
+ TPLM AA EGHL V +LLA GA++
Sbjct: 533 TQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHA 592
Query: 1129 MDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 1188
G TAL++AC GH V L+ GA +H + GRTPL AA G VQFL+
Sbjct: 593 TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Query: 1189 GAMIEHVDYSGMRP-LDRAVGCRNTSVVVTLLKKGA 1223
GA + + L A + +VV LL GA
Sbjct: 653 GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
Score = 150 bits (378), Expect = 2e-35
Identities = 109/333 (32%), Positives = 170/333 (51%), Gaps = 26/333 (7%)
Query: 859 YTPNIKVSRLLILGGANINYRTEVLNNAPI-LCVQSHLGYTEMVALLLEFGANVDASSES 917
Y ++++ R L+ GA+ ++T+ ++ A + C+ H+ E+ LLL+ GA V+ ++S
Sbjct: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV---EVARLLLDSGAQVNMPADS 466
Query: 918 GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 977
+PL AA G++ + LL ++ A ++ ++ G L+ AA GH E+V L+
Sbjct: 467 FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL------ 520
Query: 978 AGQQQGVFKKSHAIQQ-ALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGET 1036
GQ + ++ Q+ AL A G+ E+ +L+ K ++E L T
Sbjct: 521 -GQGANINAQTEETQETALTLACCGGFLEVADFLI----KAGADIE---------LGCST 566
Query: 1037 ALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMA 1096
L AA G LE+ + LL GA V G L GH + D+LL GAD+
Sbjct: 567 PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 626
Query: 1097 DKQGRTPLMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGHLSVVRSLVDN 1155
+ GRTPLM AA GH+ TV FL+++GA++ T LS AC GHL+VV L+ +
Sbjct: 627 SEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAH 686
Query: 1156 GAATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 1188
GA H K+G T L AA G VV +L+D+
Sbjct: 687 GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 147 bits (371), Expect = 1e-34
Identities = 117/370 (31%), Positives = 172/370 (46%), Gaps = 23/370 (6%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANV-DASSESGLT 920
++ R L++ G ++N TE +LC+ GY E+ +LL ANV D + +T
Sbjct: 246 DVNAVRKLLIEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDIT 303
Query: 921 PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980
PL AA G++ IV LL +A V+ G AL +A G+++VVK L++ ++
Sbjct: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH 363
Query: 981 QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTA 1040
+ H L+ A S G+ E+ LL+ A IN+ + + E+ALT
Sbjct: 364 NEN----GHT---PLMEAGSAGHVEVARLLLE---------NGAGINTHSNEFKESALTL 407
Query: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100
A +G LE+ R LLE GA L GH ++ LLL GA VNM
Sbjct: 408 ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
Query: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1160
+PL +AA GH+ L+ +GAS+ ++ EG T L A +GH +V L+ GA +
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Query: 1161 -HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219
++ T L LA G EV FL+ GA IE PL A + +V LL
Sbjct: 528 AQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPLMEAAQEGHLELVKYLL 584
Query: 1220 KKGAKIGPAT 1229
GA + T
Sbjct: 585 AAGANVHATT 594
Score = 130 bits (328), Expect = 1e-29
Identities = 150/503 (29%), Positives = 222/503 (44%), Gaps = 40/503 (7%)
Query: 860 TPNIKVSRLL-ILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESG 918
+P I S +L I +I+ +TE N+ L + G+ E+V LLE GA+++ + G
Sbjct: 1058 SPIISPSAMLPIYPAIDIDAQTES-NHDTALTLACAGGHEELVQTLLERGASIEHRDKKG 1116
Query: 919 LTPLGYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 977
TPL AA AG++ +V +L A ++ ++ L A G EVV+ L+
Sbjct: 1117 FTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLA----- 1171
Query: 978 AGQQQGVFKKSHAIQQ--ALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWG 1034
+G K+ + L AAS GY I+ LL+ A+INS S G
Sbjct: 1172 ----RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG---------AEINSRTGSKLG 1218
Query: 1035 ETALTAAAGRGKLEVCRLLLEQGA---AVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 1091
+ L AA G +LLL+ G+ A + NR A+ L QG ++V LLL A
Sbjct: 1219 ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL--ACFQGRTEVVSLLLDRKA 1276
Query: 1092 DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL--MDKEGLTALSWACLKGHLSVV 1149
+V K G TPLM AAS G+ LL +GA + + TAL+ A KGH
Sbjct: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336
Query: 1150 RSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGC 1209
L+ GA D +K G TPL LAA G +VVQ LV GA ++ D + PL A
Sbjct: 1337 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1396
Query: 1210 RNTSVVVTLLKKGAKIGPATWAM--ATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRY 1267
+ VV L+K+ + + M + D ++ L E + K + EA +
Sbjct: 1397 GHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNA 1456
Query: 1268 QYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEA 1327
L++ DL+ RE L L R +RK EE K E++ K+ E
Sbjct: 1457 SILLEEL-------DLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKEN 1509
Query: 1328 YYARARAKRSSRQFAAALEDLNE 1350
+ +A ++ + E L E
Sbjct: 1510 FELQAAQEKEKLKVEDEPEVLTE 1532
Score = 65.1 bits (157), Expect = 7e-10
Identities = 49/157 (31%), Positives = 80/157 (50%), Gaps = 16/157 (10%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
++++ + L+ GAN++ T + A ++ G+T++ +LL+ GA+++ SE G TP
Sbjct: 576 HLELVKYLLAAGANVHATTATGDTALTYACEN--GHTDVADVLLQAGADLEHESEGGRTP 633
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRG-HLEVVKFLIQCDWTMAGQ 980
L AA AG++ V L K A V+ N ++ A G HL VV+ L+
Sbjct: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA-------- 685
Query: 981 QQGVFKKSHAIQQA---LIAAASMGYTEIVSYLLDLP 1014
G +H ++ LI AA G+T +V YLLD P
Sbjct: 686 -HGA-DPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
Score = 54.3 bits (129), Expect = 1e-06
Identities = 56/192 (29%), Positives = 80/192 (41%), Gaps = 11/192 (5%)
Query: 1037 ALTAAAGRGKLEVCRLLLEQGAAVAQPN--RRGAVPLFSTVRQGHWQIVDLLLTHGADVN 1094
AL AAG GKL G A A P RR + + + + + A+
Sbjct: 177 ALLEAAGIGKLSTA-----DGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAG 231
Query: 1095 MADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVD 1154
+D + L A SEG + V LL +G S+ +EG + L AC G+ + + L+
Sbjct: 232 QSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 288
Query: 1155 NGA-ATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTS 1213
A D K TPL AA G ++V+ L+ H A + +G L A
Sbjct: 289 MHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVD 348
Query: 1214 VVVTLLKKGAKI 1225
VV LL+ GA I
Sbjct: 349 VVKVLLESGASI 360
Score = 42.7 bits (99), Expect = 0.004
Identities = 52/224 (23%), Positives = 78/224 (34%), Gaps = 18/224 (8%)
Query: 1442 SPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQN------ 1495
S S+ P + SSP Q+F +S + T T +++ +PT+
Sbjct: 1975 SSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTA 2034
Query: 1496 -SHYRPSPPHTS--PAHQGGSYRFSPPPVGGQG---------KEYPSPPPSPLRRGPQYR 1543
HY S P + PA GG R SP G +E SPP
Sbjct: 2035 KEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPN 2094
Query: 1544 ASPPAESMSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGL 1603
+S + S S + +Q P QE + P +M P PVAVP
Sbjct: 2095 SSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP 2154
Query: 1604 RLQPAKAQIVRSNQPSPAVHSSTVIPTGAYGQVAHSMASKYQSS 1647
P + QP+P + + + P H ++ Q+S
Sbjct: 2155 VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNS 2198
Score = 33.9 bits (76), Expect = 1.6
Identities = 94/402 (23%), Positives = 145/402 (36%), Gaps = 76/402 (18%)
Query: 1438 PVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALS---PTHQ 1494
PV+++ + PP+ S+ SSS S+Q S S P Q Q P + P
Sbjct: 2083 PVVETTNTRPPNSSSSSGSSS-AHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLA 2141
Query: 1495 NSHYRPSPPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAESMSVY 1554
S + P T+P +Y P+G P P+P P R PP +
Sbjct: 2142 TSSAPVAVPSTAPV----TYPMPQTPMG-------CPQPTPKMETPAIR--PPPHGTTAP 2188
Query: 1555 RSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMP---QLPVAVPQQGL---RLQPA 1608
S S Q +SV+ L +RP+ +P QLP + Q + PA
Sbjct: 2189 HKNSAS----VQNSSVAVLS-------VNHIKRPHSVPSSVQLPSTLSTQSACQNSVHPA 2237
Query: 1609 KAQIVRS-NQPSPAVHSSTVI---PTGAYGQVAHSMASKYQSSQGDIGVSQSRL-----V 1659
I + + P P ST+ PT A+ S+ S + + + S L +
Sbjct: 2238 NKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPL 2297
Query: 1660 YQGSIGGIVGDGRPVQHVQASLSAGAICQHGGLTKEDLPQ---RPSSAY--------RGG 1708
+Q G P+Q S S G+ D P PSS + GG
Sbjct: 2298 HQSDTSKAPGFRPPLQRPAPSPS--------GIVNMDSPYGSVTPSSTHLGNFASNISGG 2349
Query: 1709 VRYSQTPQIGRSQSASYYPVCH-SKLDL----ERSSSQLGSPDVSHLIRRPI-------- 1755
Y +G + +A+ + H S L L +S+ + VS +R P
Sbjct: 2350 QMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPL 2409
Query: 1756 -SVNPNEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSTSNLT 1796
S P+ + P P+ +S +R + +S SNL+
Sbjct: 2410 GSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLS 2451
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 172 bits (436), Expect = 3e-42
Identities = 132/396 (33%), Positives = 199/396 (50%), Gaps = 54/396 (13%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
++K+ +LL+ A++N ++ N A L GY ++V +LLE GA+++ +E+G TP
Sbjct: 313 HVKIVKLLLAHKADVNAQSSTGNTA--LTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980
L A +AG++ + LL + A ++ H ++ + AL A +GHLE+V+FL++ AG
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE-----AGA 425
Query: 981 QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWGETALT 1039
Q K+ + AL+ A G+ E+ LLD AQ+N DS E+ LT
Sbjct: 426 DQE--HKTDEMHTALMEACMDGHVEVARLLLD---------SGAQVNMPADSF--ESPLT 472
Query: 1040 AAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQ 1099
AA G +E+ LL+E+GA++ + N G PL R+GH ++V LLL GA++N ++
Sbjct: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532
Query: 1100 GR-------------------------------TPLMMAASEGHLGTVDFLLAQGASIAL 1128
+ TPLM AA EGHL V +LLA GA++
Sbjct: 533 TQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHA 592
Query: 1129 MDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 1188
G TAL++AC GH V L+ GA +H + GRTPL AA G VQFL+
Sbjct: 593 TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Query: 1189 GAMIEHVDYSGMRP-LDRAVGCRNTSVVVTLLKKGA 1223
GA + + L A + +VV LL GA
Sbjct: 653 GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
Score = 150 bits (378), Expect = 2e-35
Identities = 109/333 (32%), Positives = 170/333 (51%), Gaps = 26/333 (7%)
Query: 859 YTPNIKVSRLLILGGANINYRTEVLNNAPI-LCVQSHLGYTEMVALLLEFGANVDASSES 917
Y ++++ R L+ GA+ ++T+ ++ A + C+ H+ E+ LLL+ GA V+ ++S
Sbjct: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV---EVARLLLDSGAQVNMPADS 466
Query: 918 GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 977
+PL AA G++ + LL ++ A ++ ++ G L+ AA GH E+V L+
Sbjct: 467 FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL------ 520
Query: 978 AGQQQGVFKKSHAIQQ-ALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGET 1036
GQ + ++ Q+ AL A G+ E+ +L+ K ++E L T
Sbjct: 521 -GQGANINAQTEETQETALTLACCGGFLEVADFLI----KAGADIE---------LGCST 566
Query: 1037 ALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMA 1096
L AA G LE+ + LL GA V G L GH + D+LL GAD+
Sbjct: 567 PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 626
Query: 1097 DKQGRTPLMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGHLSVVRSLVDN 1155
+ GRTPLM AA GH+ TV FL+++GA++ T LS AC GHL+VV L+ +
Sbjct: 627 SEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAH 686
Query: 1156 GAATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 1188
GA H K+G T L AA G VV +L+D+
Sbjct: 687 GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 147 bits (371), Expect = 1e-34
Identities = 117/370 (31%), Positives = 172/370 (46%), Gaps = 23/370 (6%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANV-DASSESGLT 920
++ R L++ G ++N TE +LC+ GY E+ +LL ANV D + +T
Sbjct: 246 DVNAVRKLLIEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDIT 303
Query: 921 PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980
PL AA G++ IV LL +A V+ G AL +A G+++VVK L++ ++
Sbjct: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH 363
Query: 981 QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTA 1040
+ H L+ A S G+ E+ LL+ A IN+ + + E+ALT
Sbjct: 364 NEN----GHT---PLMEAGSAGHVEVARLLLE---------NGAGINTHSNEFKESALTL 407
Query: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100
A +G LE+ R LLE GA L GH ++ LLL GA VNM
Sbjct: 408 ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
Query: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1160
+PL +AA GH+ L+ +GAS+ ++ EG T L A +GH +V L+ GA +
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Query: 1161 -HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219
++ T L LA G EV FL+ GA IE PL A + +V LL
Sbjct: 528 AQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPLMEAAQEGHLELVKYLL 584
Query: 1220 KKGAKIGPAT 1229
GA + T
Sbjct: 585 AAGANVHATT 594
Score = 130 bits (328), Expect = 1e-29
Identities = 150/503 (29%), Positives = 222/503 (44%), Gaps = 40/503 (7%)
Query: 860 TPNIKVSRLL-ILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESG 918
+P I S +L I +I+ +TE N+ L + G+ E+V LLE GA+++ + G
Sbjct: 807 SPIISPSAMLPIYPAIDIDAQTES-NHDTALTLACAGGHEELVQTLLERGASIEHRDKKG 865
Query: 919 LTPLGYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 977
TPL AA AG++ +V +L A ++ ++ L A G EVV+ L+
Sbjct: 866 FTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLA----- 920
Query: 978 AGQQQGVFKKSHAIQQ--ALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWG 1034
+G K+ + L AAS GY I+ LL+ A+INS S G
Sbjct: 921 ----RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG---------AEINSRTGSKLG 967
Query: 1035 ETALTAAAGRGKLEVCRLLLEQGA---AVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 1091
+ L AA G +LLL+ G+ A + NR A+ L QG ++V LLL A
Sbjct: 968 ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL--ACFQGRTEVVSLLLDRKA 1025
Query: 1092 DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL--MDKEGLTALSWACLKGHLSVV 1149
+V K G TPLM AAS G+ LL +GA + + TAL+ A KGH
Sbjct: 1026 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1085
Query: 1150 RSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGC 1209
L+ GA D +K G TPL LAA G +VVQ LV GA ++ D + PL A
Sbjct: 1086 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1145
Query: 1210 RNTSVVVTLLKKGAKIGPATWAM--ATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRY 1267
+ VV L+K+ + + M + D ++ L E + K + EA +
Sbjct: 1146 GHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNA 1205
Query: 1268 QYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEA 1327
L++ DL+ RE L L R +RK EE K E++ K+ E
Sbjct: 1206 SILLEEL-------DLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKEN 1258
Query: 1328 YYARARAKRSSRQFAAALEDLNE 1350
+ +A ++ + E L E
Sbjct: 1259 FELQAAQEKEKLKVEDEPEVLTE 1281
Score = 119 bits (298), Expect = 3e-26
Identities = 115/406 (28%), Positives = 174/406 (42%), Gaps = 57/406 (14%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
++++ + L+ GAN++ T + A ++ G+T++ +LL+ GA+++ SE G TP
Sbjct: 576 HLELVKYLLAAGANVHATTATGDTALTYACEN--GHTDVADVLLQAGADLEHESEGGRTP 633
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRG-HLEVVKFLIQCDWTMAGQ 980
L AA AG++ V L K A V+ N ++ A G HL VV+ L+
Sbjct: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA-------- 685
Query: 981 QQGVFKKSHAIQQA---LIAAASMGYTEIVSYLLDLPEK-----------------DEEE 1020
G +H ++ LI AA G+T +V YLLD P D
Sbjct: 686 -HGA-DPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNR 743
Query: 1021 VERAQINSF---------DSLWGETALT------AAAGRGKLEVCRLLLEQGAAVAQPNR 1065
R + + D A T A +GR A+++QP
Sbjct: 744 APRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQT 803
Query: 1066 RGAVPLFSTVRQGHWQIVDLLLTHGADVN-MADKQGRTPLMMAASEGHLGTVDFLLAQGA 1124
P+ S L + D++ + T L +A + GH V LL +GA
Sbjct: 804 PTPSPIISPSAM-------LPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGA 856
Query: 1125 SIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD-HADKNGRTPLDLAAFYGDAEVVQ 1183
SI DK+G T L A GH+ VV L+DNGA + +++ TPL LA G EVV+
Sbjct: 857 SIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVE 916
Query: 1184 FLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPAT 1229
L+ GA EH + S PL A +++ LL GA+I T
Sbjct: 917 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 962
Score = 54.3 bits (129), Expect = 1e-06
Identities = 56/192 (29%), Positives = 80/192 (41%), Gaps = 11/192 (5%)
Query: 1037 ALTAAAGRGKLEVCRLLLEQGAAVAQPN--RRGAVPLFSTVRQGHWQIVDLLLTHGADVN 1094
AL AAG GKL G A A P RR + + + + + A+
Sbjct: 177 ALLEAAGIGKLSTA-----DGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAG 231
Query: 1095 MADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVD 1154
+D + L A SEG + V LL +G S+ +EG + L AC G+ + + L+
Sbjct: 232 QSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 288
Query: 1155 NGA-ATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTS 1213
A D K TPL AA G ++V+ L+ H A + +G L A
Sbjct: 289 MHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVD 348
Query: 1214 VVVTLLKKGAKI 1225
VV LL+ GA I
Sbjct: 349 VVKVLLESGASI 360
Score = 42.7 bits (99), Expect = 0.004
Identities = 52/224 (23%), Positives = 78/224 (34%), Gaps = 18/224 (8%)
Query: 1442 SPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQN------ 1495
S S+ P + SSP Q+F +S + T T +++ +PT+
Sbjct: 1724 SSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTA 1783
Query: 1496 -SHYRPSPPHTS--PAHQGGSYRFSPPPVGGQG---------KEYPSPPPSPLRRGPQYR 1543
HY S P + PA GG R SP G +E SPP
Sbjct: 1784 KEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPN 1843
Query: 1544 ASPPAESMSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGL 1603
+S + S S + +Q P QE + P +M P PVAVP
Sbjct: 1844 SSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP 1903
Query: 1604 RLQPAKAQIVRSNQPSPAVHSSTVIPTGAYGQVAHSMASKYQSS 1647
P + QP+P + + + P H ++ Q+S
Sbjct: 1904 VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNS 1947
Score = 33.9 bits (76), Expect = 1.6
Identities = 94/402 (23%), Positives = 145/402 (36%), Gaps = 76/402 (18%)
Query: 1438 PVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALS---PTHQ 1494
PV+++ + PP+ S+ SSS S+Q S S P Q Q P + P
Sbjct: 1832 PVVETTNTRPPNSSSSSGSSS-AHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLA 1890
Query: 1495 NSHYRPSPPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAESMSVY 1554
S + P T+P +Y P+G P P+P P R PP +
Sbjct: 1891 TSSAPVAVPSTAPV----TYPMPQTPMG-------CPQPTPKMETPAIR--PPPHGTTAP 1937
Query: 1555 RSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMP---QLPVAVPQQGL---RLQPA 1608
S S Q +SV+ L +RP+ +P QLP + Q + PA
Sbjct: 1938 HKNSAS----VQNSSVAVLS-------VNHIKRPHSVPSSVQLPSTLSTQSACQNSVHPA 1986
Query: 1609 KAQIVRS-NQPSPAVHSSTVI---PTGAYGQVAHSMASKYQSSQGDIGVSQSRL-----V 1659
I + + P P ST+ PT A+ S+ S + + + S L +
Sbjct: 1987 NKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPL 2046
Query: 1660 YQGSIGGIVGDGRPVQHVQASLSAGAICQHGGLTKEDLPQ---RPSSAY--------RGG 1708
+Q G P+Q S S G+ D P PSS + GG
Sbjct: 2047 HQSDTSKAPGFRPPLQRPAPSPS--------GIVNMDSPYGSVTPSSTHLGNFASNISGG 2098
Query: 1709 VRYSQTPQIGRSQSASYYPVCH-SKLDL----ERSSSQLGSPDVSHLIRRPI-------- 1755
Y +G + +A+ + H S L L +S+ + VS +R P
Sbjct: 2099 QMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPL 2158
Query: 1756 -SVNPNEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSTSNLT 1796
S P+ + P P+ +S +R + +S SNL+
Sbjct: 2159 GSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLS 2200
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 164 bits (416), Expect = 6e-40
Identities = 128/395 (32%), Positives = 196/395 (49%), Gaps = 54/395 (13%)
Query: 863 IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922
+ + +LL+L A++N ++ N A L G+ ++V +LL GAN++ +E+G TPL
Sbjct: 285 LDIVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 342
Query: 923 GYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
AA+AG++ + +L A ++ H ++ + AL A +GHL++V+FL++ AG
Sbjct: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-----AGAD 397
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWGETALTA 1040
Q K+ + AL+ A G+ E+ LLD AQ+N DS E+ LT
Sbjct: 398 QE--HKTDEMHTALMEACMDGHVEVARLLLD---------SGAQVNMPADSF--ESPLTL 444
Query: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100
AA G +E+ LL+E+GA + + N G PL R+GH ++V LLL GA++N ++
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
Query: 1101 R-------------------------------TPLMMAASEGHLGTVDFLLAQGASIALM 1129
+ TPLM A+ EGHL V +LLA GA++
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHAT 564
Query: 1130 DKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHG 1189
G TAL++AC GH V L+ GA +H + GRTPL AA G VQFL+ G
Sbjct: 565 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKG 624
Query: 1190 AMIEHVDYSGMRP-LDRAVGCRNTSVVVTLLKKGA 1223
A + + + A + +VV LL GA
Sbjct: 625 ANVNRATANNDHTVVSLACAGGHLAVVELLLAHGA 659
Score = 148 bits (373), Expect = 6e-35
Identities = 106/332 (31%), Positives = 167/332 (50%), Gaps = 24/332 (7%)
Query: 859 YTPNIKVSRLLILGGANINYRTEVLNNAPI-LCVQSHLGYTEMVALLLEFGANVDASSES 917
Y ++ + R L+ GA+ ++T+ ++ A + C+ H+ E+ LLL+ GA V+ ++S
Sbjct: 381 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV---EVARLLLDSGAQVNMPADS 437
Query: 918 GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 977
+PL AA G++ + LL ++ A ++ ++ G L+ AA GH E+V L+ +
Sbjct: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
Query: 978 AGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETA 1037
Q + + AL A G++E+ +L+ K ++E L T
Sbjct: 498 NAQTE------ETQETALTLACCGGFSEVADFLI----KAGADIE---------LGCSTP 538
Query: 1038 LTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMAD 1097
L A+ G LE+ + LL GA V G L GH + D+LL GAD+
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 1098 KQGRTPLMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGHLSVVRSLVDNG 1156
+ GRTPLM AA GHL TV FL+++GA++ T +S AC GHL+VV L+ +G
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 1157 AATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 1188
A H K+G T L AA G VV +L+D+
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 132 bits (333), Expect = 3e-30
Identities = 107/364 (29%), Positives = 155/364 (42%), Gaps = 52/364 (14%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G V LL+ G +V+ +E G + L A +AGY + +L A V+ G
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
L+AA+S GY +IV LL
Sbjct: 275 --------------------------------------PLMAASSGGYLDIVKLLL---- 292
Query: 1016 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTV 1075
+ A +NS S G TALT A G +++ ++LL +GA + N G PL
Sbjct: 293 -----LHDADVNS-QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAA 346
Query: 1076 RQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEGL 1134
GH ++ +LL HGA +N + + + L +A +GHL V FLL GA E
Sbjct: 347 SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
Query: 1135 TALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEH 1194
TAL AC+ GH+ V R L+D+GA + + +PL LAA G E+ L++ GA +E
Sbjct: 407 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 466
Query: 1195 VDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMF 1254
V+ G PL A + +V LL +GA I T T + + + E D
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT--EETQETALTLACCGGFSEVADFL 524
Query: 1255 YKKG 1258
K G
Sbjct: 525 IKAG 528
Score = 122 bits (305), Expect = 5e-27
Identities = 103/322 (31%), Positives = 152/322 (47%), Gaps = 19/322 (5%)
Query: 868 LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGL-TPLGYAA 926
+LI A I +R + IL + G+ +V +LL+ G +++A SE TPL A
Sbjct: 1073 VLIARDAKIEHRDKKGFTPLILAATA--GHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130
Query: 927 AAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFK 986
+ G +V LL + A +H + + L AA G++ ++K L+ AG +
Sbjct: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN-----AGAEINSRT 1185
Query: 987 KSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGK 1046
S L+ AA G+ V LLD+ ++E + TALT A +G+
Sbjct: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR---------NTALTLACFQGR 1236
Query: 1047 LEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNM--ADKQGRTPL 1104
EV LLL++ A V + G PL G+ ++ +LL GADVN T L
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
Query: 1105 MMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADK 1164
+AA +GH + L+ +GA I + +K+G T L A GH VV+ LV GA D AD
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356
Query: 1165 NGRTPLDLAAFYGDAEVVQFLV 1186
TPL A G +VVQ+LV
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLV 1378
Score = 120 bits (302), Expect = 1e-26
Identities = 94/296 (31%), Positives = 145/296 (48%), Gaps = 21/296 (7%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
++ V +L+ G +I ++E + P+ S G E+V LLL GAN + + S TP
Sbjct: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSG-GRQEVVDLLLARGANKEHRNVSDYTP 1158
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHL--DKNGQCALVHAALRGHLEVVKFLIQCDWTMAG 979
L AA+ GY++I+ +L A+++ K G L+ AA+ GH+ VK L+ +
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINA 1218
Query: 980 QQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALT 1039
Q + AL A G E+VS LLD E + G T L
Sbjct: 1219 QIET------NRNTALTLACFQGRAEVVSLLLDRKANVEHRAKT----------GLTPLM 1262
Query: 1040 AAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVR--QGHWQIVDLLLTHGADVNMAD 1097
AA G EV R+LL++GA V P + T+ +GH++ +LL+ GA +++ +
Sbjct: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
Query: 1098 KQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLV 1153
K+G TPL +A++ GH V L+ GA + D +T L A KGH+ VV+ LV
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
Score = 117 bits (294), Expect = 9e-26
Identities = 109/335 (32%), Positives = 157/335 (46%), Gaps = 29/335 (8%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCA 954
G+ E+V++L+ A ++ + G TPL AA AG++ +V +L K ++ ++
Sbjct: 1066 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 1125
Query: 955 LVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQ--ALIAAASMGYTEIVSYLLD 1012
L A G EVV L+ +G K+ + L AAS GY I+ LL+
Sbjct: 1126 LSLACSGGRQEVVDLLLA---------RGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 1013 LPEKDEEEVERAQINS-FDSLWGETALTAAAGRGKLEVCRLLLEQGA---AVAQPNRRGA 1068
A+INS S G + L AA G + +LLL+ G+ A + NR A
Sbjct: 1177 AG---------AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTA 1227
Query: 1069 VPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL 1128
+ L QG ++V LLL A+V K G TPLM AAS G+ LL +GA +
Sbjct: 1228 LTL--ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1285
Query: 1129 --MDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1186
+ TAL+ A KGH L+ GA D +K G TPL LA+ G +VVQ LV
Sbjct: 1286 PPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1345
Query: 1187 DHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKK 1221
GA ++ D + PL A + VV L+K+
Sbjct: 1346 QAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 105 bits (263), Expect = 3e-22
Identities = 81/236 (34%), Positives = 114/236 (48%), Gaps = 14/236 (5%)
Query: 994 ALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLL 1053
AL A + G+ E+VS L+ K E ++ G T L AA G + V +L
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKK----------GFTPLILAATAGHVGVVEIL 1107
Query: 1054 LEQGAAV-AQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGH 1112
L++G + AQ R PL G ++VDLLL GA+ + TPL +AAS G+
Sbjct: 1108 LDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGY 1167
Query: 1113 LGTVDFLLAQGASIALM--DKEGLTALSWACLKGHLSVVRSLVDNGAATD-HADKNGRTP 1169
+ + LL GA I K G++ L A + GH+ V+ L+D G+ + + N T
Sbjct: 1168 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTA 1227
Query: 1170 LDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1225
L LA F G AEVV L+D A +EH +G+ PL A V LL KGA +
Sbjct: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
Score = 72.8 bits (177), Expect = 3e-12
Identities = 67/243 (27%), Positives = 104/243 (42%), Gaps = 28/243 (11%)
Query: 859 YTPNIKVSR--------LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGAN 910
YTP ++ +R LL+ GANIN +TE L + G++E+ L++ GA+
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA-LTLACCGGFSEVADFLIKAGAD 530
Query: 911 VDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFL 970
++ TPL A+ G+L +V L A V G AL +A GH +V L
Sbjct: 531 IELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Query: 971 IQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFD 1030
+Q + + +G + L+ AA G+ V +L+ V RA N+
Sbjct: 588 LQAGADLEHESEGG-------RTPLMKAARAGHLCTVQFLIS----KGANVNRATANN-- 634
Query: 1031 SLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHG 1090
T ++ A G L V LLL GA + G+ L + GH +V LL +
Sbjct: 635 ---DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYP 691
Query: 1091 ADV 1093
+V
Sbjct: 692 NNV 694
Score = 72.0 bits (175), Expect = 5e-12
Identities = 47/129 (36%), Positives = 64/129 (49%), Gaps = 1/129 (0%)
Query: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD- 1160
T L +A + GH V L+A+ A I DK+G T L A GH+ VV L+D G +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 1161 HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLK 1220
+++ TPL LA G EVV L+ GA EH + S PL A +++ LL
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 1221 KGAKIGPAT 1229
GA+I T
Sbjct: 1177 AGAEINSRT 1185
Score = 43.1 bits (100), Expect = 0.003
Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 9/95 (9%)
Query: 1161 HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLK 1220
H + N T L LA G E+V L+ A IEH D G PL A + VV LL
Sbjct: 1050 HTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
Query: 1221 KGAKI---------GPATWAMATSKPDIMIILLSK 1246
KG I P + A + + +++ +LL++
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLAR 1144
Score = 36.6 bits (83), Expect = 0.25
Identities = 34/120 (28%), Positives = 54/120 (45%), Gaps = 9/120 (7%)
Query: 1136 ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHV 1195
+L+ AC G ++ VR L+D G + + + G + L LA G E+ Q L+ A +E
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 1196 DYSG-MRPLDRAVGCRNTSVVVTLLKKGAKIG--------PATWAMATSKPDIMIILLSK 1246
G + PL A +V LL A + T+A A DI+ +LL++
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Score = 34.7 bits (78), Expect = 0.96
Identities = 46/179 (25%), Positives = 71/179 (39%), Gaps = 15/179 (8%)
Query: 1433 PSQGLPVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPT 1492
P+ + + S SS P SA I+S G +S+S + Q +S S A+ PT
Sbjct: 1972 PATVISSVTSTCSSLPSVSSAPITS---GQAPTTFLPASTSQAQLSSQKMESFS-AVPPT 2027
Query: 1493 HQ--NSHYRPSPPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAES 1550
+ ++ +P +P+ S S G + +PS P+P Q A P + S
Sbjct: 2028 KEKVSTQDQPMANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVS 2087
Query: 1551 MSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMA--QRPYQMPQLPVAVPQQGLRLQP 1607
SP+ ++ P SP A Q +PQL V P+ R+QP
Sbjct: 2088 -------DLSPMSMPFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQP 2139
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 164 bits (416), Expect = 6e-40
Identities = 128/395 (32%), Positives = 196/395 (49%), Gaps = 54/395 (13%)
Query: 863 IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922
+ + +LL+L A++N ++ N A L G+ ++V +LL GAN++ +E+G TPL
Sbjct: 285 LDIVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 342
Query: 923 GYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
AA+AG++ + +L A ++ H ++ + AL A +GHL++V+FL++ AG
Sbjct: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-----AGAD 397
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWGETALTA 1040
Q K+ + AL+ A G+ E+ LLD AQ+N DS E+ LT
Sbjct: 398 QE--HKTDEMHTALMEACMDGHVEVARLLLD---------SGAQVNMPADSF--ESPLTL 444
Query: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100
AA G +E+ LL+E+GA + + N G PL R+GH ++V LLL GA++N ++
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
Query: 1101 R-------------------------------TPLMMAASEGHLGTVDFLLAQGASIALM 1129
+ TPLM A+ EGHL V +LLA GA++
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHAT 564
Query: 1130 DKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHG 1189
G TAL++AC GH V L+ GA +H + GRTPL AA G VQFL+ G
Sbjct: 565 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKG 624
Query: 1190 AMIEHVDYSGMRP-LDRAVGCRNTSVVVTLLKKGA 1223
A + + + A + +VV LL GA
Sbjct: 625 ANVNRATANNDHTVVSLACAGGHLAVVELLLAHGA 659
Score = 148 bits (373), Expect = 6e-35
Identities = 106/332 (31%), Positives = 167/332 (50%), Gaps = 24/332 (7%)
Query: 859 YTPNIKVSRLLILGGANINYRTEVLNNAPI-LCVQSHLGYTEMVALLLEFGANVDASSES 917
Y ++ + R L+ GA+ ++T+ ++ A + C+ H+ E+ LLL+ GA V+ ++S
Sbjct: 381 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV---EVARLLLDSGAQVNMPADS 437
Query: 918 GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 977
+PL AA G++ + LL ++ A ++ ++ G L+ AA GH E+V L+ +
Sbjct: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
Query: 978 AGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETA 1037
Q + + AL A G++E+ +L+ K ++E L T
Sbjct: 498 NAQTE------ETQETALTLACCGGFSEVADFLI----KAGADIE---------LGCSTP 538
Query: 1038 LTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMAD 1097
L A+ G LE+ + LL GA V G L GH + D+LL GAD+
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 1098 KQGRTPLMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGHLSVVRSLVDNG 1156
+ GRTPLM AA GHL TV FL+++GA++ T +S AC GHL+VV L+ +G
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 1157 AATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 1188
A H K+G T L AA G VV +L+D+
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 132 bits (333), Expect = 3e-30
Identities = 107/364 (29%), Positives = 155/364 (42%), Gaps = 52/364 (14%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G V LL+ G +V+ +E G + L A +AGY + +L A V+ G
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
L+AA+S GY +IV LL
Sbjct: 275 --------------------------------------PLMAASSGGYLDIVKLLL---- 292
Query: 1016 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTV 1075
+ A +NS S G TALT A G +++ ++LL +GA + N G PL
Sbjct: 293 -----LHDADVNS-QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAA 346
Query: 1076 RQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEGL 1134
GH ++ +LL HGA +N + + + L +A +GHL V FLL GA E
Sbjct: 347 SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
Query: 1135 TALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEH 1194
TAL AC+ GH+ V R L+D+GA + + +PL LAA G E+ L++ GA +E
Sbjct: 407 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 466
Query: 1195 VDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMF 1254
V+ G PL A + +V LL +GA I T T + + + E D
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT--EETQETALTLACCGGFSEVADFL 524
Query: 1255 YKKG 1258
K G
Sbjct: 525 IKAG 528
Score = 122 bits (305), Expect = 5e-27
Identities = 103/322 (31%), Positives = 152/322 (47%), Gaps = 19/322 (5%)
Query: 868 LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGL-TPLGYAA 926
+LI A I +R + IL + G+ +V +LL+ G +++A SE TPL A
Sbjct: 1073 VLIARDAKIEHRDKKGFTPLILAATA--GHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130
Query: 927 AAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFK 986
+ G +V LL + A +H + + L AA G++ ++K L+ AG +
Sbjct: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN-----AGAEINSRT 1185
Query: 987 KSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGK 1046
S L+ AA G+ V LLD+ ++E + TALT A +G+
Sbjct: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR---------NTALTLACFQGR 1236
Query: 1047 LEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNM--ADKQGRTPL 1104
EV LLL++ A V + G PL G+ ++ +LL GADVN T L
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
Query: 1105 MMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADK 1164
+AA +GH + L+ +GA I + +K+G T L A GH VV+ LV GA D AD
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356
Query: 1165 NGRTPLDLAAFYGDAEVVQFLV 1186
TPL A G +VVQ+LV
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLV 1378
Score = 120 bits (302), Expect = 1e-26
Identities = 94/296 (31%), Positives = 145/296 (48%), Gaps = 21/296 (7%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
++ V +L+ G +I ++E + P+ S G E+V LLL GAN + + S TP
Sbjct: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSG-GRQEVVDLLLARGANKEHRNVSDYTP 1158
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHL--DKNGQCALVHAALRGHLEVVKFLIQCDWTMAG 979
L AA+ GY++I+ +L A+++ K G L+ AA+ GH+ VK L+ +
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINA 1218
Query: 980 QQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALT 1039
Q + AL A G E+VS LLD E + G T L
Sbjct: 1219 QIET------NRNTALTLACFQGRAEVVSLLLDRKANVEHRAKT----------GLTPLM 1262
Query: 1040 AAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVR--QGHWQIVDLLLTHGADVNMAD 1097
AA G EV R+LL++GA V P + T+ +GH++ +LL+ GA +++ +
Sbjct: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
Query: 1098 KQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLV 1153
K+G TPL +A++ GH V L+ GA + D +T L A KGH+ VV+ LV
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
Score = 117 bits (294), Expect = 9e-26
Identities = 109/335 (32%), Positives = 157/335 (46%), Gaps = 29/335 (8%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCA 954
G+ E+V++L+ A ++ + G TPL AA AG++ +V +L K ++ ++
Sbjct: 1066 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 1125
Query: 955 LVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQ--ALIAAASMGYTEIVSYLLD 1012
L A G EVV L+ +G K+ + L AAS GY I+ LL+
Sbjct: 1126 LSLACSGGRQEVVDLLLA---------RGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 1013 LPEKDEEEVERAQINS-FDSLWGETALTAAAGRGKLEVCRLLLEQGA---AVAQPNRRGA 1068
A+INS S G + L AA G + +LLL+ G+ A + NR A
Sbjct: 1177 AG---------AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTA 1227
Query: 1069 VPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL 1128
+ L QG ++V LLL A+V K G TPLM AAS G+ LL +GA +
Sbjct: 1228 LTL--ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1285
Query: 1129 --MDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1186
+ TAL+ A KGH L+ GA D +K G TPL LA+ G +VVQ LV
Sbjct: 1286 PPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1345
Query: 1187 DHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKK 1221
GA ++ D + PL A + VV L+K+
Sbjct: 1346 QAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 105 bits (263), Expect = 3e-22
Identities = 81/236 (34%), Positives = 114/236 (48%), Gaps = 14/236 (5%)
Query: 994 ALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLL 1053
AL A + G+ E+VS L+ K E ++ G T L AA G + V +L
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKK----------GFTPLILAATAGHVGVVEIL 1107
Query: 1054 LEQGAAV-AQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGH 1112
L++G + AQ R PL G ++VDLLL GA+ + TPL +AAS G+
Sbjct: 1108 LDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGY 1167
Query: 1113 LGTVDFLLAQGASIALM--DKEGLTALSWACLKGHLSVVRSLVDNGAATD-HADKNGRTP 1169
+ + LL GA I K G++ L A + GH+ V+ L+D G+ + + N T
Sbjct: 1168 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTA 1227
Query: 1170 LDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1225
L LA F G AEVV L+D A +EH +G+ PL A V LL KGA +
Sbjct: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
Score = 72.8 bits (177), Expect = 3e-12
Identities = 67/243 (27%), Positives = 104/243 (42%), Gaps = 28/243 (11%)
Query: 859 YTPNIKVSR--------LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGAN 910
YTP ++ +R LL+ GANIN +TE L + G++E+ L++ GA+
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA-LTLACCGGFSEVADFLIKAGAD 530
Query: 911 VDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFL 970
++ TPL A+ G+L +V L A V G AL +A GH +V L
Sbjct: 531 IELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Query: 971 IQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFD 1030
+Q + + +G + L+ AA G+ V +L+ V RA N+
Sbjct: 588 LQAGADLEHESEGG-------RTPLMKAARAGHLCTVQFLIS----KGANVNRATANN-- 634
Query: 1031 SLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHG 1090
T ++ A G L V LLL GA + G+ L + GH +V LL +
Sbjct: 635 ---DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYP 691
Query: 1091 ADV 1093
+V
Sbjct: 692 NNV 694
Score = 72.0 bits (175), Expect = 5e-12
Identities = 47/129 (36%), Positives = 64/129 (49%), Gaps = 1/129 (0%)
Query: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD- 1160
T L +A + GH V L+A+ A I DK+G T L A GH+ VV L+D G +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 1161 HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLK 1220
+++ TPL LA G EVV L+ GA EH + S PL A +++ LL
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 1221 KGAKIGPAT 1229
GA+I T
Sbjct: 1177 AGAEINSRT 1185
Score = 43.1 bits (100), Expect = 0.003
Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 9/95 (9%)
Query: 1161 HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLK 1220
H + N T L LA G E+V L+ A IEH D G PL A + VV LL
Sbjct: 1050 HTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
Query: 1221 KGAKI---------GPATWAMATSKPDIMIILLSK 1246
KG I P + A + + +++ +LL++
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLAR 1144
Score = 36.6 bits (83), Expect = 0.25
Identities = 34/120 (28%), Positives = 54/120 (45%), Gaps = 9/120 (7%)
Query: 1136 ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHV 1195
+L+ AC G ++ VR L+D G + + + G + L LA G E+ Q L+ A +E
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 1196 DYSG-MRPLDRAVGCRNTSVVVTLLKKGAKIG--------PATWAMATSKPDIMIILLSK 1246
G + PL A +V LL A + T+A A DI+ +LL++
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Score = 34.7 bits (78), Expect = 0.96
Identities = 46/179 (25%), Positives = 71/179 (39%), Gaps = 15/179 (8%)
Query: 1433 PSQGLPVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPT 1492
P+ + + S SS P SA I+S G +S+S + Q +S S A+ PT
Sbjct: 1972 PATVISSVTSTCSSLPSVSSAPITS---GQAPTTFLPASTSQAQLSSQKMESFS-AVPPT 2027
Query: 1493 HQ--NSHYRPSPPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAES 1550
+ ++ +P +P+ S S G + +PS P+P Q A P + S
Sbjct: 2028 KEKVSTQDQPMANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVS 2087
Query: 1551 MSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMA--QRPYQMPQLPVAVPQQGLRLQP 1607
SP+ ++ P SP A Q +PQL V P+ R+QP
Sbjct: 2088 -------DLSPMSMPFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQP 2139
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 159 bits (403), Expect = 2e-38
Identities = 133/422 (31%), Positives = 201/422 (47%), Gaps = 65/422 (15%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+V++LL+ AN N R LN L + +++ LL+++GA++ A +ESGLTP+
Sbjct: 358 RVTKLLLDKRANPNARA--LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIH 415
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983
AA G+L+IV+LL + A D + G+ AL AA G +EVV+ L++
Sbjct: 416 VAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR-------NGAL 468
Query: 984 VFKKSHAIQQALIAAASMGYTEIVSYLLD-LPEKD---------------EEEVERAQI- 1026
V ++ Q L A+ +G TEIV LL + D E +V+ A +
Sbjct: 469 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528
Query: 1027 ------NSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLF-------- 1072
+S + G T L AA G L+V +LLL++ AA + G PL
Sbjct: 529 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 588
Query: 1073 --------------STVRQGH-----------WQIVDLLLTHGADVNMADKQGRTPLMMA 1107
+T + G+ QI LL +GA+ N+ KQG TPL +A
Sbjct: 589 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 648
Query: 1108 ASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGR 1167
+ EGH V LL +GA+I + K GLT+L A + ++V L +GA D K G
Sbjct: 649 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 708
Query: 1168 TPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGP 1227
TPL +A YG+ ++V FL+ GA + +G PL +A +T ++ LL+ GAK
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768
Query: 1228 AT 1229
T
Sbjct: 769 TT 770
Score = 137 bits (346), Expect = 8e-32
Identities = 116/371 (31%), Positives = 166/371 (44%), Gaps = 58/371 (15%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
N+ V+ LL+ GA +++ N L V S G T MV LLL+ G +DA + GLTP
Sbjct: 224 NVNVATLLLNRGAAVDFTAR--NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 281
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
L AA +G+ +V LL ++ A + KNG L AA H+E VK L+Q
Sbjct: 282 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--------- 332
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
+A + ++ Y TAL A
Sbjct: 333 ----------HKAPVDDVTLDYL-------------------------------TALHVA 351
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRR---GAVPLFSTVRQGHWQIVDLLLTHGADVNMADK 1098
A G V +LLL++ A PN R G PL ++ ++++LL+ +GA + +
Sbjct: 352 AHCGHYRVTKLLLDKRA---NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 408
Query: 1099 QGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAA 1158
G TP+ +AA GHL V LL GAS + + G TAL A G + VVR L+ NGA
Sbjct: 409 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 468
Query: 1159 TDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTL 1218
D + +TPL +A+ G E+VQ L+ H A + +G PL + V L
Sbjct: 469 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528
Query: 1219 LKKGAKIGPAT 1229
L+ GA AT
Sbjct: 529 LEAGAAHSLAT 539
Score = 137 bits (344), Expect = 1e-31
Identities = 111/361 (30%), Positives = 171/361 (47%), Gaps = 17/361 (4%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+V ++L+ GANIN +++ N L + + + ++V LLE GAN ++E G TPL
Sbjct: 90 EVVKVLVKEGANINAQSQ--NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 147
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983
A G+ V +L + K K AL AA + + L+Q D Q +
Sbjct: 148 VALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKM 203
Query: 984 VFKKS-HAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAA 1042
+ ++ + L AA G + + LL+ R F + G T L A+
Sbjct: 204 MVNRTTESGFTPLHIAAHYGNVNVATLLLN----------RGAAVDFTARNGITPLHVAS 253
Query: 1043 GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRT 1102
RG + +LLL++G + R G PL R GH Q+V+LLL GA + K G +
Sbjct: 254 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS 313
Query: 1103 PLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHA 1162
PL MAA H+ V LL A + + + LTAL A GH V + L+D A +
Sbjct: 314 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 373
Query: 1163 DKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKG 1222
NG TPL +A +V++ LV +GA I+ + SG+ P+ A + ++V+ LL+ G
Sbjct: 374 ALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNG 433
Query: 1223 A 1223
A
Sbjct: 434 A 434
Score = 114 bits (286), Expect = 7e-25
Identities = 101/355 (28%), Positives = 148/355 (41%), Gaps = 34/355 (9%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G + V L+ G +++ +++GL L AA G++ +V L + + VD K G AL
Sbjct: 21 GNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTAL 80
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLD--- 1012
A+L G EVVK L++ + Q Q F L AA + ++V YLL+
Sbjct: 81 HIASLAGQAEVVKVLVKEGANINAQSQNGF-------TPLYMAAQENHIDVVKYLLENGA 133
Query: 1013 ----------------LPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQ 1056
L + + V N AL AA + + LLL+
Sbjct: 134 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 193
Query: 1057 G--------AAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAA 1108
V + G PL G+ + LLL GA V+ + G TPL +A+
Sbjct: 194 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 253
Query: 1109 SEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRT 1168
G+ V LL +G I ++GLT L A GH VV L++ GA KNG +
Sbjct: 254 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS 313
Query: 1169 PLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
PL +AA E V+ L+ H A ++ V + L A C + V LL K A
Sbjct: 314 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 368
Score = 105 bits (263), Expect = 3e-22
Identities = 100/342 (29%), Positives = 148/342 (43%), Gaps = 54/342 (15%)
Query: 925 AAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGV 984
AA AG L VV K ++ ++NG AL AA GH+ +V+ L+ G+ V
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL-------GRGSSV 69
Query: 985 FKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGR 1044
+ AL A+ G E+V L+ E A IN+ S G T L AA
Sbjct: 70 DSATKKGNTALHIASLAGQAEVVKVLVK---------EGANINA-QSQNGFTPLYMAAQE 119
Query: 1045 GKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLL----------------- 1087
++V + LLE GA + G PL ++QGH Q V +LL
Sbjct: 120 NHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAA 179
Query: 1088 --------------THGAD------VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIA 1127
H AD VN + G TPL +AA G++ LL +GA++
Sbjct: 180 RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 239
Query: 1128 LMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVD 1187
+ G+T L A +G+ ++V+ L+D G D ++G TPL AA G +VV+ L++
Sbjct: 240 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 299
Query: 1188 HGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPAT 1229
GA + +G+ PL A + V LL+ A + T
Sbjct: 300 RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 341
Score = 95.1 bits (235), Expect = 6e-19
Identities = 77/283 (27%), Positives = 124/283 (43%), Gaps = 48/283 (16%)
Query: 984 VFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAG 1043
+ +KS + L AA + ++V YL K ++ N G AL AA
Sbjct: 4 MLQKSDSNASFLRAARAGNLDKVVEYL-----KGGIDINTCNQN------GLNALHLAAK 52
Query: 1044 RGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTP 1103
G + + + LL +G++V ++G L G ++V +L+ GA++N + G TP
Sbjct: 53 EGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTP 112
Query: 1104 LMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGA------ 1157
L MAA E H+ V +LL GA+ + ++G T L+ A +GH V L++N
Sbjct: 113 LYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL 172
Query: 1158 -------------------ATDH------------ADKNGRTPLDLAAFYGDAEVVQFLV 1186
DH ++G TPL +AA YG+ V L+
Sbjct: 173 PALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLL 232
Query: 1187 DHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPAT 1229
+ GA ++ +G+ PL A NT++V LL +G +I T
Sbjct: 233 NRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 275
Score = 57.4 bits (137), Expect = 1e-07
Identities = 39/108 (36%), Positives = 60/108 (55%), Gaps = 2/108 (1%)
Query: 863 IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922
+ V+ +L GA+ + T+ L P++ V H G +MV LL+ GANV+A +++G TPL
Sbjct: 687 VNVADILTKHGADQDAHTK-LGYTPLI-VACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 744
Query: 923 GYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFL 970
AA G+ I+ +L + AK + NG AL A G++ VV L
Sbjct: 745 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 159 bits (403), Expect = 2e-38
Identities = 133/422 (31%), Positives = 201/422 (47%), Gaps = 65/422 (15%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+V++LL+ AN N R LN L + +++ LL+++GA++ A +ESGLTP+
Sbjct: 379 RVTKLLLDKRANPNARA--LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIH 436
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983
AA G+L+IV+LL + A D + G+ AL AA G +EVV+ L++
Sbjct: 437 VAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR-------NGAL 489
Query: 984 VFKKSHAIQQALIAAASMGYTEIVSYLLD-LPEKD---------------EEEVERAQI- 1026
V ++ Q L A+ +G TEIV LL + D E +V+ A +
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Query: 1027 ------NSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLF-------- 1072
+S + G T L AA G L+V +LLL++ AA + G PL
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609
Query: 1073 --------------STVRQGH-----------WQIVDLLLTHGADVNMADKQGRTPLMMA 1107
+T + G+ QI LL +GA+ N+ KQG TPL +A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 1108 ASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGR 1167
+ EGH V LL +GA+I + K GLT+L A + ++V L +GA D K G
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
Query: 1168 TPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGP 1227
TPL +A YG+ ++V FL+ GA + +G PL +A +T ++ LL+ GAK
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 1228 AT 1229
T
Sbjct: 790 TT 791
Score = 137 bits (346), Expect = 8e-32
Identities = 116/371 (31%), Positives = 166/371 (44%), Gaps = 58/371 (15%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
N+ V+ LL+ GA +++ N L V S G T MV LLL+ G +DA + GLTP
Sbjct: 245 NVNVATLLLNRGAAVDFTAR--NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 302
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
L AA +G+ +V LL ++ A + KNG L AA H+E VK L+Q
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--------- 353
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
+A + ++ Y TAL A
Sbjct: 354 ----------HKAPVDDVTLDYL-------------------------------TALHVA 372
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRR---GAVPLFSTVRQGHWQIVDLLLTHGADVNMADK 1098
A G V +LLL++ A PN R G PL ++ ++++LL+ +GA + +
Sbjct: 373 AHCGHYRVTKLLLDKRA---NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429
Query: 1099 QGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAA 1158
G TP+ +AA GHL V LL GAS + + G TAL A G + VVR L+ NGA
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489
Query: 1159 TDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTL 1218
D + +TPL +A+ G E+VQ L+ H A + +G PL + V L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Query: 1219 LKKGAKIGPAT 1229
L+ GA AT
Sbjct: 550 LEAGAAHSLAT 560
Score = 137 bits (344), Expect = 1e-31
Identities = 111/361 (30%), Positives = 171/361 (47%), Gaps = 17/361 (4%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+V ++L+ GANIN +++ N L + + + ++V LLE GAN ++E G TPL
Sbjct: 111 EVVKVLVKEGANINAQSQ--NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 168
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983
A G+ V +L + K K AL AA + + L+Q D Q +
Sbjct: 169 VALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKM 224
Query: 984 VFKKS-HAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAA 1042
+ ++ + L AA G + + LL+ R F + G T L A+
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLN----------RGAAVDFTARNGITPLHVAS 274
Query: 1043 GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRT 1102
RG + +LLL++G + R G PL R GH Q+V+LLL GA + K G +
Sbjct: 275 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS 334
Query: 1103 PLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHA 1162
PL MAA H+ V LL A + + + LTAL A GH V + L+D A +
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 394
Query: 1163 DKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKG 1222
NG TPL +A +V++ LV +GA I+ + SG+ P+ A + ++V+ LL+ G
Sbjct: 395 ALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNG 454
Query: 1223 A 1223
A
Sbjct: 455 A 455
Score = 114 bits (286), Expect = 7e-25
Identities = 101/355 (28%), Positives = 148/355 (41%), Gaps = 34/355 (9%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G + V L+ G +++ +++GL L AA G++ +V L + + VD K G AL
Sbjct: 42 GNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTAL 101
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLD--- 1012
A+L G EVVK L++ + Q Q F L AA + ++V YLL+
Sbjct: 102 HIASLAGQAEVVKVLVKEGANINAQSQNGF-------TPLYMAAQENHIDVVKYLLENGA 154
Query: 1013 ----------------LPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQ 1056
L + + V N AL AA + + LLL+
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 1057 G--------AAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAA 1108
V + G PL G+ + LLL GA V+ + G TPL +A+
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274
Query: 1109 SEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRT 1168
G+ V LL +G I ++GLT L A GH VV L++ GA KNG +
Sbjct: 275 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS 334
Query: 1169 PLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
PL +AA E V+ L+ H A ++ V + L A C + V LL K A
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 389
Score = 105 bits (263), Expect = 3e-22
Identities = 100/342 (29%), Positives = 148/342 (43%), Gaps = 54/342 (15%)
Query: 925 AAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGV 984
AA AG L VV K ++ ++NG AL AA GH+ +V+ L+ G+ V
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL-------GRGSSV 90
Query: 985 FKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGR 1044
+ AL A+ G E+V L+ E A IN+ S G T L AA
Sbjct: 91 DSATKKGNTALHIASLAGQAEVVKVLVK---------EGANINA-QSQNGFTPLYMAAQE 140
Query: 1045 GKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLL----------------- 1087
++V + LLE GA + G PL ++QGH Q V +LL
Sbjct: 141 NHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAA 200
Query: 1088 --------------THGAD------VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIA 1127
H AD VN + G TPL +AA G++ LL +GA++
Sbjct: 201 RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260
Query: 1128 LMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVD 1187
+ G+T L A +G+ ++V+ L+D G D ++G TPL AA G +VV+ L++
Sbjct: 261 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Query: 1188 HGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPAT 1229
GA + +G+ PL A + V LL+ A + T
Sbjct: 321 RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362
Score = 96.3 bits (238), Expect = 3e-19
Identities = 78/281 (27%), Positives = 123/281 (43%), Gaps = 48/281 (17%)
Query: 986 KKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRG 1045
KKS + L AA + ++V YL K ++ N G AL AA G
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYL-----KGGIDINTCNQN------GLNALHLAAKEG 75
Query: 1046 KLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1105
+ + + LL +G++V ++G L G ++V +L+ GA++N + G TPL
Sbjct: 76 HVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 135
Query: 1106 MAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGA-------- 1157
MAA E H+ V +LL GA+ + ++G T L+ A +GH V L++N
Sbjct: 136 MAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPA 195
Query: 1158 -----------------ATDH------------ADKNGRTPLDLAAFYGDAEVVQFLVDH 1188
DH ++G TPL +AA YG+ V L++
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 1189 GAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPAT 1229
GA ++ +G+ PL A NT++V LL +G +I T
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 296
Score = 57.4 bits (137), Expect = 1e-07
Identities = 39/108 (36%), Positives = 60/108 (55%), Gaps = 2/108 (1%)
Query: 863 IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922
+ V+ +L GA+ + T+ L P++ V H G +MV LL+ GANV+A +++G TPL
Sbjct: 708 VNVADILTKHGADQDAHTK-LGYTPLI-VACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765
Query: 923 GYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFL 970
AA G+ I+ +L + AK + NG AL A G++ VV L
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 159 bits (403), Expect = 2e-38
Identities = 133/422 (31%), Positives = 201/422 (47%), Gaps = 65/422 (15%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+V++LL+ AN N R LN L + +++ LL+++GA++ A +ESGLTP+
Sbjct: 379 RVTKLLLDKRANPNARA--LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIH 436
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983
AA G+L+IV+LL + A D + G+ AL AA G +EVV+ L++
Sbjct: 437 VAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR-------NGAL 489
Query: 984 VFKKSHAIQQALIAAASMGYTEIVSYLLD-LPEKD---------------EEEVERAQI- 1026
V ++ Q L A+ +G TEIV LL + D E +V+ A +
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Query: 1027 ------NSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLF-------- 1072
+S + G T L AA G L+V +LLL++ AA + G PL
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609
Query: 1073 --------------STVRQGH-----------WQIVDLLLTHGADVNMADKQGRTPLMMA 1107
+T + G+ QI LL +GA+ N+ KQG TPL +A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 1108 ASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGR 1167
+ EGH V LL +GA+I + K GLT+L A + ++V L +GA D K G
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
Query: 1168 TPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGP 1227
TPL +A YG+ ++V FL+ GA + +G PL +A +T ++ LL+ GAK
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 1228 AT 1229
T
Sbjct: 790 TT 791
Score = 137 bits (346), Expect = 8e-32
Identities = 116/371 (31%), Positives = 166/371 (44%), Gaps = 58/371 (15%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
N+ V+ LL+ GA +++ N L V S G T MV LLL+ G +DA + GLTP
Sbjct: 245 NVNVATLLLNRGAAVDFTAR--NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 302
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
L AA +G+ +V LL ++ A + KNG L AA H+E VK L+Q
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--------- 353
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
+A + ++ Y TAL A
Sbjct: 354 ----------HKAPVDDVTLDYL-------------------------------TALHVA 372
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRR---GAVPLFSTVRQGHWQIVDLLLTHGADVNMADK 1098
A G V +LLL++ A PN R G PL ++ ++++LL+ +GA + +
Sbjct: 373 AHCGHYRVTKLLLDKRA---NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429
Query: 1099 QGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAA 1158
G TP+ +AA GHL V LL GAS + + G TAL A G + VVR L+ NGA
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489
Query: 1159 TDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTL 1218
D + +TPL +A+ G E+VQ L+ H A + +G PL + V L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Query: 1219 LKKGAKIGPAT 1229
L+ GA AT
Sbjct: 550 LEAGAAHSLAT 560
Score = 137 bits (344), Expect = 1e-31
Identities = 111/361 (30%), Positives = 171/361 (47%), Gaps = 17/361 (4%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+V ++L+ GANIN +++ N L + + + ++V LLE GAN ++E G TPL
Sbjct: 111 EVVKVLVKEGANINAQSQ--NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 168
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983
A G+ V +L + K K AL AA + + L+Q D Q +
Sbjct: 169 VALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKM 224
Query: 984 VFKKS-HAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAA 1042
+ ++ + L AA G + + LL+ R F + G T L A+
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLN----------RGAAVDFTARNGITPLHVAS 274
Query: 1043 GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRT 1102
RG + +LLL++G + R G PL R GH Q+V+LLL GA + K G +
Sbjct: 275 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS 334
Query: 1103 PLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHA 1162
PL MAA H+ V LL A + + + LTAL A GH V + L+D A +
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 394
Query: 1163 DKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKG 1222
NG TPL +A +V++ LV +GA I+ + SG+ P+ A + ++V+ LL+ G
Sbjct: 395 ALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNG 454
Query: 1223 A 1223
A
Sbjct: 455 A 455
Score = 114 bits (286), Expect = 7e-25
Identities = 101/355 (28%), Positives = 148/355 (41%), Gaps = 34/355 (9%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G + V L+ G +++ +++GL L AA G++ +V L + + VD K G AL
Sbjct: 42 GNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTAL 101
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLD--- 1012
A+L G EVVK L++ + Q Q F L AA + ++V YLL+
Sbjct: 102 HIASLAGQAEVVKVLVKEGANINAQSQNGF-------TPLYMAAQENHIDVVKYLLENGA 154
Query: 1013 ----------------LPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQ 1056
L + + V N AL AA + + LLL+
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 1057 G--------AAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAA 1108
V + G PL G+ + LLL GA V+ + G TPL +A+
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274
Query: 1109 SEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRT 1168
G+ V LL +G I ++GLT L A GH VV L++ GA KNG +
Sbjct: 275 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS 334
Query: 1169 PLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
PL +AA E V+ L+ H A ++ V + L A C + V LL K A
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 389
Score = 105 bits (263), Expect = 3e-22
Identities = 100/342 (29%), Positives = 148/342 (43%), Gaps = 54/342 (15%)
Query: 925 AAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGV 984
AA AG L VV K ++ ++NG AL AA GH+ +V+ L+ G+ V
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL-------GRGSSV 90
Query: 985 FKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGR 1044
+ AL A+ G E+V L+ E A IN+ S G T L AA
Sbjct: 91 DSATKKGNTALHIASLAGQAEVVKVLVK---------EGANINA-QSQNGFTPLYMAAQE 140
Query: 1045 GKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLL----------------- 1087
++V + LLE GA + G PL ++QGH Q V +LL
Sbjct: 141 NHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAA 200
Query: 1088 --------------THGAD------VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIA 1127
H AD VN + G TPL +AA G++ LL +GA++
Sbjct: 201 RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260
Query: 1128 LMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVD 1187
+ G+T L A +G+ ++V+ L+D G D ++G TPL AA G +VV+ L++
Sbjct: 261 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Query: 1188 HGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPAT 1229
GA + +G+ PL A + V LL+ A + T
Sbjct: 321 RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362
Score = 96.3 bits (238), Expect = 3e-19
Identities = 78/281 (27%), Positives = 123/281 (43%), Gaps = 48/281 (17%)
Query: 986 KKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRG 1045
KKS + L AA + ++V YL K ++ N G AL AA G
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYL-----KGGIDINTCNQN------GLNALHLAAKEG 75
Query: 1046 KLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1105
+ + + LL +G++V ++G L G ++V +L+ GA++N + G TPL
Sbjct: 76 HVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 135
Query: 1106 MAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGA-------- 1157
MAA E H+ V +LL GA+ + ++G T L+ A +GH V L++N
Sbjct: 136 MAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPA 195
Query: 1158 -----------------ATDH------------ADKNGRTPLDLAAFYGDAEVVQFLVDH 1188
DH ++G TPL +AA YG+ V L++
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 1189 GAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPAT 1229
GA ++ +G+ PL A NT++V LL +G +I T
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 296
Score = 57.4 bits (137), Expect = 1e-07
Identities = 39/108 (36%), Positives = 60/108 (55%), Gaps = 2/108 (1%)
Query: 863 IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922
+ V+ +L GA+ + T+ L P++ V H G +MV LL+ GANV+A +++G TPL
Sbjct: 708 VNVADILTKHGADQDAHTK-LGYTPLI-VACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765
Query: 923 GYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFL 970
AA G+ I+ +L + AK + NG AL A G++ VV L
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 36.6 bits (83), Expect = 0.25
Identities = 41/155 (26%), Positives = 59/155 (38%), Gaps = 6/155 (3%)
Query: 1444 PSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQST--SPALSPTHQNSHYRPS 1501
PS R S SS+ H S + SP + ++ SPA S + H S
Sbjct: 1823 PSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVS 1882
Query: 1502 PPHTSPAHQGGSYRFSP--PPVGGQGKEYPSPPPSPLRRGPQY-RASPPAESMSVYRSQS 1558
P + H S + PPV GK PP SP R ++ SP + S S
Sbjct: 1883 PSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPS 1942
Query: 1559 GSPVRYQQETSVSQLPGR-PKSPLSKMAQRPYQMP 1592
G ++Q ++ + P SP K ++P P
Sbjct: 1943 GRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSP 1977
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 150 bits (378), Expect = 2e-35
Identities = 134/427 (31%), Positives = 180/427 (42%), Gaps = 71/427 (16%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
NI V+ LL+ A +++ N+ L V S G MV LLL+ GA +DA + GLTP
Sbjct: 247 NINVATLLLNRAAAVDFTAR--NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTP 304
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNG----------------QCALVH-------- 957
L A +G+ +V +L + A + KNG Q L H
Sbjct: 305 LHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT 364
Query: 958 ---------AALRGHLEVVKFL-------------------IQCDWTMAGQQQGVFKKSH 989
AA GH +V K L I C + + K
Sbjct: 365 NDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGA 424
Query: 990 AIQQA-------LIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAA 1042
+IQ + AA MG+ IVS L+ A N+ ++ GETAL AA
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMH---------HGASPNT-TNVRGETALHMAA 474
Query: 1043 GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRT 1102
G+ EV R L++ GA V + PL + R G IV LL GA N A G T
Sbjct: 475 RSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYT 534
Query: 1103 PLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHA 1162
PL ++A EGH FLL GAS+++ K+G T L A G L V L+ A+ D A
Sbjct: 535 PLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAA 594
Query: 1163 DKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKG 1222
K+G TPL +AA Y + +V L+D GA +G PL A + TLL+ G
Sbjct: 595 GKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654
Query: 1223 AKIGPAT 1229
A T
Sbjct: 655 ADANAVT 661
Score = 147 bits (370), Expect = 1e-34
Identities = 120/409 (29%), Positives = 183/409 (44%), Gaps = 51/409 (12%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
KV+++L+ AN N + LN L + +++ LLL+ GA++ A +ESGLTP+
Sbjct: 381 KVAKVLLDKKANPN--AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIH 438
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQ- 982
AA G+++IV L A + + G+ AL AA G EVV++L+Q + + +
Sbjct: 439 VAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKD 498
Query: 983 --------GVFKKSHAIQQALIAAASMGYTEIVSYL-LDLPEKDEEE------VERAQIN 1027
K+ +QQ L AS Y L L ++ E ++
Sbjct: 499 DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558
Query: 1028 SFDSLWGETALTAAAGRGKLEVCRLLLE-------------------------------- 1055
S + G T L AA GKLEV LLL+
Sbjct: 559 SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618
Query: 1056 -QGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLG 1114
QGA+ + G PL ++ I LL +GAD N +QG + +AA EGH+
Sbjct: 619 DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD 678
Query: 1115 TVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAA 1174
V LL + A++ L +K GLT L A + ++V LV+ GA D K G TPL +
Sbjct: 679 MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGC 738
Query: 1175 FYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
YG+ ++V FL+ H A + +G PL +A +T ++ LL+ A
Sbjct: 739 HYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA 787
Score = 141 bits (356), Expect = 6e-33
Identities = 120/399 (30%), Positives = 175/399 (43%), Gaps = 47/399 (11%)
Query: 870 ILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAG 929
I G +IN + N L + S G+ E+V+ LL+ ANVDA+++ G T L A+ AG
Sbjct: 61 IKNGVDINICNQ--NGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAG 118
Query: 930 YLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMA-GQQQGVFKKS 988
+V +L A V+ +NG L AA HLEVVKFL+ + + + G +
Sbjct: 119 QAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLA 178
Query: 989 HAIQQ---------------------ALIAAASMGYTEIVSYLLDLPEKDEEE------- 1020
A+QQ AL AA T+ + LL + E
Sbjct: 179 VALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTP 238
Query: 1021 ----------------VERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPN 1064
+ RA F + T L A+ RG + +LLL++GA +
Sbjct: 239 LHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKT 298
Query: 1065 RRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGA 1124
R G PL R GH Q+V++LL A + K G +PL MA HL V LL
Sbjct: 299 RDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Query: 1125 SIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQF 1184
+ + + LTAL A GH V + L+D A + NG TPL +A +V++
Sbjct: 359 PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMEL 418
Query: 1185 LVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
L+ HGA I+ V SG+ P+ A + ++V L+ GA
Sbjct: 419 LLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 457
Score = 135 bits (339), Expect = 5e-31
Identities = 102/339 (30%), Positives = 162/339 (47%), Gaps = 21/339 (6%)
Query: 889 LCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLD 948
L V +H G+ ++ +LL+ AN +A + +G TPL A + ++ LL K A + +
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430
Query: 949 KNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAI--QQALIAAASMGYTEI 1006
++G + AA GH+ +V L+ G + + + AL AA G E+
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMH---------HGASPNTTNVRGETALHMAARSGQAEV 481
Query: 1007 VSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRR 1066
V YL+ +D +VE + +T L +A GK ++ + LL+QGA+
Sbjct: 482 VRYLV----QDGAQVEAKAKDD------QTPLHISARLGKADIVQQLLQQGASPNAATTS 531
Query: 1067 GAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASI 1126
G PL + R+GH + LL HGA +++ K+G TPL +AA G L + LL + AS
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591
Query: 1127 ALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1186
K GLT L A + V L+D GA+ A KNG TPL +AA ++ L+
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL 651
Query: 1187 DHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1225
++GA V G+ + A + +V LL + A +
Sbjct: 652 EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV 690
Score = 129 bits (324), Expect = 3e-29
Identities = 101/355 (28%), Positives = 158/355 (44%), Gaps = 19/355 (5%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+V R L+ GA + + + ++ L + + LG ++V LL+ GA+ +A++ SG TPL
Sbjct: 480 EVVRYLVQDGAQVEAKAK--DDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLH 537
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983
+A G+ + L A + K G L AA G LEV L+Q + +
Sbjct: 538 LSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKS 597
Query: 984 VFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAG 1043
H AA ++ LLD + G T L AA
Sbjct: 598 GLTPLHV-------AAHYDNQKVALLLLDQGASPHAAAKN----------GYTPLHIAAK 640
Query: 1044 RGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTP 1103
+ ++++ LLE GA R+G + ++GH +V LLL A+VN+++K G TP
Sbjct: 641 KNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTP 700
Query: 1104 LMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHAD 1163
L +AA E + + L+ QGA + K G T L C G++ +V L+ + A +
Sbjct: 701 LHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT 760
Query: 1164 KNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTL 1218
KNG TPL AA G ++ L+ + A + +G L A SVV TL
Sbjct: 761 KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
Score = 120 bits (301), Expect = 1e-26
Identities = 107/379 (28%), Positives = 158/379 (41%), Gaps = 45/379 (11%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G+ E ++ G +++ +++GL L A+ G++ +V L ++ A VD K G AL
Sbjct: 52 GHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTAL 111
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQ---------------------- 993
A+L G EVVK L+ + Q Q F + Q
Sbjct: 112 HIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATE 171
Query: 994 ----ALIAAASMGYTEIVSYLLD--------LP------EKDEEEVERAQINS-----FD 1030
L A G+ ++VS LL+ LP KD+ + + + +
Sbjct: 172 DGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVE 231
Query: 1031 SLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHG 1090
S G T L AA G + V LLL + AAV R PL ++G+ +V LLL G
Sbjct: 232 SKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRG 291
Query: 1091 ADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVR 1150
A ++ + G TPL A GH V+ LL + A I K GL+ L A HL+ V+
Sbjct: 292 AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQ 351
Query: 1151 SLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCR 1210
L+ + D + T L +AA G +V + L+D A +G PL A
Sbjct: 352 LLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKN 411
Query: 1211 NTSVVVTLLKKGAKIGPAT 1229
V+ LLK GA I T
Sbjct: 412 RIKVMELLLKHGASIQAVT 430
Score = 106 bits (265), Expect = 2e-22
Identities = 93/334 (27%), Positives = 146/334 (43%), Gaps = 46/334 (13%)
Query: 925 AAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGV 984
AA AG+L + K ++ ++NG AL A+ GH+EVV L+Q ++ V
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQ-------REANV 100
Query: 985 FKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGR 1044
+ AL A+ G E+V L+ A +N+ S G T L AA
Sbjct: 101 DAATKKGNTALHIASLAGQAEVVKVLV---------TNGANVNA-QSQNGFTPLYMAAQE 150
Query: 1045 GKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA------------- 1091
LEV + LL+ GA+ + G PL ++QGH Q+V LLL +
Sbjct: 151 NHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAA 210
Query: 1092 ----------------DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLT 1135
+ ++ K G TPL +AA G++ LL + A++ + +T
Sbjct: 211 RKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDIT 270
Query: 1136 ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHV 1195
L A +G+ ++V+ L+D GA D ++G TPL A G +VV+ L+D A I
Sbjct: 271 PLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSK 330
Query: 1196 DYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPAT 1229
+G+ PL A + + V LL+ + T
Sbjct: 331 TKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT 364
Score = 83.2 bits (204), Expect = 2e-15
Identities = 56/175 (32%), Positives = 89/175 (50%), Gaps = 1/175 (0%)
Query: 1014 PEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFS 1073
PEK + +R++ S + L AA G LE ++ G + N+ G L
Sbjct: 22 PEKKRKHRKRSRDRKKKSDANASYLRAARA-GHLEKALDYIKNGVDINICNQNGLNALHL 80
Query: 1074 TVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEG 1133
++GH ++V LL A+V+ A K+G T L +A+ G V L+ GA++ + G
Sbjct: 81 ASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNG 140
Query: 1134 LTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 1188
T L A + HL VV+ L+DNGA+ A ++G TPL +A G +VV L+++
Sbjct: 141 FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
Score = 70.9 bits (172), Expect = 1e-11
Identities = 46/125 (36%), Positives = 61/125 (48%)
Query: 1105 MMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADK 1164
+ AA GHL + G I + ++ GL AL A +GH+ VV L+ A D A K
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK 105
Query: 1165 NGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAK 1224
G T L +A+ G AEVV+ LV +GA + +G PL A + VV LL GA
Sbjct: 106 KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS 165
Query: 1225 IGPAT 1229
AT
Sbjct: 166 QSLAT 170
Score = 54.3 bits (129), Expect = 1e-06
Identities = 36/108 (33%), Positives = 60/108 (55%), Gaps = 2/108 (1%)
Query: 863 IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922
+ V+ +L+ GA+++ +T+ + P L V H G ++V LL+ A V+A +++G TPL
Sbjct: 710 VNVAEVLVNQGAHVDAQTK-MGYTP-LHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPL 767
Query: 923 GYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFL 970
AA G+ I+ +L + A + L NG AL A G++ VV L
Sbjct: 768 HQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
Score = 32.0 bits (71), Expect = 6.2
Identities = 23/77 (29%), Positives = 36/77 (46%), Gaps = 4/77 (5%)
Query: 1382 PPPPQPQQQLPEEAEPEPQHEDIYSVQDIFEEEYLEQDVENVSIGLQTEARPSQG-LPVI 1440
P P P ++ EE+E E Q + Q EE +E+++ N + + RP + I
Sbjct: 3194 PGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAVEREMPN-DVSKDSNQRPKNNRVAYI 3252
Query: 1441 QSPPSSPPHRDSAYISS 1457
+ PP PP D+ I S
Sbjct: 3253 EFPP--PPPLDADQIES 3267
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 [Homo
sapiens]
Length = 627
Score = 148 bits (374), Expect = 5e-35
Identities = 118/363 (32%), Positives = 179/363 (49%), Gaps = 21/363 (5%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+++++L+ AN+ R + P++ S GY ++V LLL A+V++ S +G T L
Sbjct: 252 ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 310
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983
YA A G++ IV +L + A ++ ++NG L+ AA GH+EV + L+
Sbjct: 311 YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLD-HGAGINTHSN 369
Query: 984 VFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAG 1043
FK+S AL A G+ ++V +LL+ E + + TAL A
Sbjct: 370 EFKES-----ALTLACYKGHLDMVRFLLEAGADQEHKTDEM----------HTALMEACM 414
Query: 1044 RGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTP 1103
G +EV RLLL+ GA V P PL GH ++ LL+ GA++ + +G TP
Sbjct: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474
Query: 1104 LMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHA 1162
LM AA EGH V LLAQGA+I A ++ TAL+ AC G V L+ GA
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DI 531
Query: 1163 DKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKG 1222
+ TPL A+ G E+V++L+ GA + +G L A +T V LL+ G
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 1223 AKI 1225
A +
Sbjct: 592 ADL 594
Score = 144 bits (364), Expect = 7e-34
Identities = 116/370 (31%), Positives = 171/370 (46%), Gaps = 23/370 (6%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANV-DASSESGLT 920
++ R L+ G ++N TE +LC+ GY E+ +LL ANV D ++ +T
Sbjct: 217 DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
Query: 921 PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980
PL A++ GYL IV LL A V+ G AL +A G +++VK L+ +
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL-------NE 327
Query: 981 QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTA 1040
+ + L+ AAS G+ E+ LLD A IN+ + + E+ALT
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLD---------HGAGINTHSNEFKESALTL 378
Query: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100
A +G L++ R LLE GA L GH ++ LLL GA VNM
Sbjct: 379 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 438
Query: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1160
+PL +AA GH+ L+ +GA++ ++ EG T L A +GH +V L+ GA +
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Query: 1161 -HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219
++ T L LA G +EV FL+ GA IE PL A + +V LL
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLL 555
Query: 1220 KKGAKIGPAT 1229
GA + T
Sbjct: 556 ASGANVHATT 565
Score = 140 bits (352), Expect = 2e-32
Identities = 109/334 (32%), Positives = 172/334 (51%), Gaps = 26/334 (7%)
Query: 863 IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922
+ + +LL+L A++N ++ N A L G+ ++V +LL GAN++ +E+G TPL
Sbjct: 285 LDIVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 342
Query: 923 GYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
AA+AG++ + +L A ++ H ++ + AL A +GHL++V+FL++ AG
Sbjct: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-----AGAD 397
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWGETALTA 1040
Q K+ + AL+ A G+ E+ LLD AQ+N DS E+ LT
Sbjct: 398 QE--HKTDEMHTALMEACMDGHVEVARLLLD---------SGAQVNMPADSF--ESPLTL 444
Query: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVN-MADKQ 1099
AA G +E+ LL+E+GA + + N G PL R+GH ++V LLL GA++N ++
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
Query: 1100 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1159
T L +A G DFL+ GA I L T L A +GHL +V+ L+ +GA
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANV 561
Query: 1160 DHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1193
G T L A G +V L+ GA ++
Sbjct: 562 HATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 132 bits (333), Expect = 3e-30
Identities = 107/364 (29%), Positives = 155/364 (42%), Gaps = 52/364 (14%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G V LL+ G +V+ +E G + L A +AGY + +L A V+ G
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
L+AA+S GY +IV LL
Sbjct: 275 --------------------------------------PLMAASSGGYLDIVKLLL---- 292
Query: 1016 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTV 1075
+ A +NS S G TALT A G +++ ++LL +GA + N G PL
Sbjct: 293 -----LHDADVNS-QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAA 346
Query: 1076 RQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEGL 1134
GH ++ +LL HGA +N + + + L +A +GHL V FLL GA E
Sbjct: 347 SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
Query: 1135 TALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEH 1194
TAL AC+ GH+ V R L+D+GA + + +PL LAA G E+ L++ GA +E
Sbjct: 407 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 466
Query: 1195 VDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMF 1254
V+ G PL A + +V LL +GA I T T + + + E D
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT--EETQETALTLACCGGFSEVADFL 524
Query: 1255 YKKG 1258
K G
Sbjct: 525 IKAG 528
Score = 36.6 bits (83), Expect = 0.25
Identities = 34/120 (28%), Positives = 54/120 (45%), Gaps = 9/120 (7%)
Query: 1136 ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHV 1195
+L+ AC G ++ VR L+D G + + + G + L LA G E+ Q L+ A +E
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 1196 DYSG-MRPLDRAVGCRNTSVVVTLLKKGAKIG--------PATWAMATSKPDIMIILLSK 1246
G + PL A +V LL A + T+A A DI+ +LL++
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 [Homo
sapiens]
Length = 616
Score = 148 bits (374), Expect = 5e-35
Identities = 118/363 (32%), Positives = 179/363 (49%), Gaps = 21/363 (5%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+++++L+ AN+ R + P++ S GY ++V LLL A+V++ S +G T L
Sbjct: 241 ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 299
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983
YA A G++ IV +L + A ++ ++NG L+ AA GH+EV + L+
Sbjct: 300 YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLD-HGAGINTHSN 358
Query: 984 VFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAG 1043
FK+S AL A G+ ++V +LL+ E + + TAL A
Sbjct: 359 EFKES-----ALTLACYKGHLDMVRFLLEAGADQEHKTDEM----------HTALMEACM 403
Query: 1044 RGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTP 1103
G +EV RLLL+ GA V P PL GH ++ LL+ GA++ + +G TP
Sbjct: 404 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 463
Query: 1104 LMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHA 1162
LM AA EGH V LLAQGA+I A ++ TAL+ AC G V L+ GA
Sbjct: 464 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DI 520
Query: 1163 DKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKG 1222
+ TPL A+ G E+V++L+ GA + +G L A +T V LL+ G
Sbjct: 521 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
Query: 1223 AKI 1225
A +
Sbjct: 581 ADL 583
Score = 144 bits (364), Expect = 7e-34
Identities = 116/370 (31%), Positives = 171/370 (46%), Gaps = 23/370 (6%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANV-DASSESGLT 920
++ R L+ G ++N TE +LC+ GY E+ +LL ANV D ++ +T
Sbjct: 206 DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 263
Query: 921 PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980
PL A++ GYL IV LL A V+ G AL +A G +++VK L+ +
Sbjct: 264 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL-------NE 316
Query: 981 QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTA 1040
+ + L+ AAS G+ E+ LLD A IN+ + + E+ALT
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLD---------HGAGINTHSNEFKESALTL 367
Query: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100
A +G L++ R LLE GA L GH ++ LLL GA VNM
Sbjct: 368 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 427
Query: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1160
+PL +AA GH+ L+ +GA++ ++ EG T L A +GH +V L+ GA +
Sbjct: 428 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 487
Query: 1161 -HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219
++ T L LA G +EV FL+ GA IE PL A + +V LL
Sbjct: 488 AQTEETQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLL 544
Query: 1220 KKGAKIGPAT 1229
GA + T
Sbjct: 545 ASGANVHATT 554
Score = 140 bits (352), Expect = 2e-32
Identities = 109/334 (32%), Positives = 172/334 (51%), Gaps = 26/334 (7%)
Query: 863 IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922
+ + +LL+L A++N ++ N A L G+ ++V +LL GAN++ +E+G TPL
Sbjct: 274 LDIVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 331
Query: 923 GYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
AA+AG++ + +L A ++ H ++ + AL A +GHL++V+FL++ AG
Sbjct: 332 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-----AGAD 386
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWGETALTA 1040
Q K+ + AL+ A G+ E+ LLD AQ+N DS E+ LT
Sbjct: 387 QE--HKTDEMHTALMEACMDGHVEVARLLLD---------SGAQVNMPADSF--ESPLTL 433
Query: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVN-MADKQ 1099
AA G +E+ LL+E+GA + + N G PL R+GH ++V LLL GA++N ++
Sbjct: 434 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 493
Query: 1100 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1159
T L +A G DFL+ GA I L T L A +GHL +V+ L+ +GA
Sbjct: 494 QETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANV 550
Query: 1160 DHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1193
G T L A G +V L+ GA ++
Sbjct: 551 HATTATGDTALTYACENGHTDVADVLLQAGADLD 584
Score = 132 bits (333), Expect = 3e-30
Identities = 107/364 (29%), Positives = 155/364 (42%), Gaps = 52/364 (14%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G V LL+ G +V+ +E G + L A +AGY + +L A V+ G
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 263
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
L+AA+S GY +IV LL
Sbjct: 264 --------------------------------------PLMAASSGGYLDIVKLLL---- 281
Query: 1016 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTV 1075
+ A +NS S G TALT A G +++ ++LL +GA + N G PL
Sbjct: 282 -----LHDADVNS-QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAA 335
Query: 1076 RQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEGL 1134
GH ++ +LL HGA +N + + + L +A +GHL V FLL GA E
Sbjct: 336 SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 395
Query: 1135 TALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEH 1194
TAL AC+ GH+ V R L+D+GA + + +PL LAA G E+ L++ GA +E
Sbjct: 396 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 455
Query: 1195 VDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMF 1254
V+ G PL A + +V LL +GA I T T + + + E D
Sbjct: 456 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT--EETQETALTLACCGGFSEVADFL 513
Query: 1255 YKKG 1258
K G
Sbjct: 514 IKAG 517
Score = 36.6 bits (83), Expect = 0.25
Identities = 34/120 (28%), Positives = 54/120 (45%), Gaps = 9/120 (7%)
Query: 1136 ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHV 1195
+L+ AC G ++ VR L+D G + + + G + L LA G E+ Q L+ A +E
Sbjct: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
Query: 1196 DYSG-MRPLDRAVGCRNTSVVVTLLKKGAKIG--------PATWAMATSKPDIMIILLSK 1246
G + PL A +V LL A + T+A A DI+ +LL++
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 147 bits (372), Expect = 8e-35
Identities = 119/378 (31%), Positives = 184/378 (48%), Gaps = 18/378 (4%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
+++V LL+ GA+I+ TE + L V S +G+ +V LL+ GA+ + S+ TP
Sbjct: 416 HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 473
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDW-----T 976
L AA AG+ + L + +AKV+ K+ Q L AA GH +VK L++ + T
Sbjct: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 533
Query: 977 MAGQ-------QQGVFKKSHAIQQALIAAASM---GYTEI-VSYLLDLPEKDEEEVERAQ 1025
AG ++G + A+ + + A M G+T + V+ E +ER
Sbjct: 534 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 593
Query: 1026 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDL 1085
+ G T L A L++ +LLL +G + P G PL +Q ++
Sbjct: 594 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 653
Query: 1086 LLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGH 1145
LL +G N QG TPL +AA EGH V LL++ A+ L +K GLT L +GH
Sbjct: 654 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 713
Query: 1146 LSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDR 1205
+ V L+ +G D + G TPL +A+ YG+ ++V+FL+ H A + G PL +
Sbjct: 714 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 773
Query: 1206 AVGCRNTSVVVTLLKKGA 1223
A +T +V LLK GA
Sbjct: 774 AAQQGHTDIVTLLLKNGA 791
Score = 142 bits (358), Expect = 3e-33
Identities = 118/405 (29%), Positives = 187/405 (46%), Gaps = 28/405 (6%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
++++S +L+ GA I +T+ N + + + + + V LLL++ A +D + LTP
Sbjct: 317 HVRISEILLDHGAPIQAKTK--NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 374
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
L AA G+ + +L K AK + NG L A + H+ V++ L++ ++
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 434
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
+ H A+ MG+ IV LL +R + ++ ET L A
Sbjct: 435 ESGLTPLHV-------ASFMGHLPIVKNLL----------QRGASPNVSNVKVETPLHMA 477
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
A G EV + LL+ A V + PL R GH +V LLL + A+ N+A G
Sbjct: 478 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 537
Query: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
TPL +AA EGH+ TV LL + AS A M K+G T L A G + V L++ A +
Sbjct: 538 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 597
Query: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKK 1221
A KNG TPL +A + + ++V+ L+ G ++G PL A V +LL+
Sbjct: 598 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 657
Query: 1222 GAK--------IGPATWAMATSKPDIMIILLSKLMEEGDMFYKKG 1258
G + P A +++ +LLSK G++ K G
Sbjct: 658 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSG 701
Score = 132 bits (331), Expect = 4e-30
Identities = 110/351 (31%), Positives = 155/351 (44%), Gaps = 34/351 (9%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G E+V L+ +GANV+A S+ G TPL AA +L +V L + A + ++G L
Sbjct: 122 GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 181
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
A +GH VV LI K AL AA T + LL
Sbjct: 182 AVALQQGHENVVAHLINYG-----------TKGKVRLPALHIAARNDDTRTAAVLLQNDP 230
Query: 1016 KDE----------------EEVERAQIN-------SFDSLWGETALTAAAGRGKLEVCRL 1052
+ E + AQ+ +F G T L A+ RG + + RL
Sbjct: 231 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 290
Query: 1053 LLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGH 1112
LL++GA + + PL R GH +I ++LL HGA + K G +P+ MAA H
Sbjct: 291 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 350
Query: 1113 LGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDL 1172
L V LL A I + + LT L A GH V + L+D GA + NG TPL +
Sbjct: 351 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 410
Query: 1173 AAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
A V++ L+ GA I+ V SG+ PL A + +V LL++GA
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 461
Score = 130 bits (326), Expect = 2e-29
Identities = 102/342 (29%), Positives = 162/342 (47%), Gaps = 23/342 (6%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+V++ L+ A +N + + + P+ C + +G+T MV LLLE AN + ++ +G TPL
Sbjct: 484 EVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTPLH 541
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCD-WTMAGQQQ 982
AA G++ V+ L +K A + K G L AA G + V + L++ D A +
Sbjct: 542 IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 601
Query: 983 GVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLW-GETALTAA 1041
G+ L A +IV LL W G T L A
Sbjct: 602 GL--------TPLHVAVHHNNLDIVKLLLPRGGSPHSPA-----------WNGYTPLHIA 642
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
A + ++EV R LL+ G + + +G PL ++GH ++V LLL+ A+ N+ +K G
Sbjct: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702
Query: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
TPL + A EGH+ D L+ G + + G T L A G++ +V+ L+ + A +
Sbjct: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762
Query: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1203
K G +PL AA G ++V L+ +GA V G PL
Sbjct: 763 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 804
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 147 bits (372), Expect = 8e-35
Identities = 119/378 (31%), Positives = 184/378 (48%), Gaps = 18/378 (4%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
+++V LL+ GA+I+ TE + L V S +G+ +V LL+ GA+ + S+ TP
Sbjct: 383 HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDW-----T 976
L AA AG+ + L + +AKV+ K+ Q L AA GH +VK L++ + T
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 977 MAGQ-------QQGVFKKSHAIQQALIAAASM---GYTEI-VSYLLDLPEKDEEEVERAQ 1025
AG ++G + A+ + + A M G+T + V+ E +ER
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 1026 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDL 1085
+ G T L A L++ +LLL +G + P G PL +Q ++
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 1086 LLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGH 1145
LL +G N QG TPL +AA EGH V LL++ A+ L +K GLT L +GH
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 1146 LSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDR 1205
+ V L+ +G D + G TPL +A+ YG+ ++V+FL+ H A + G PL +
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 1206 AVGCRNTSVVVTLLKKGA 1223
A +T +V LLK GA
Sbjct: 741 AAQQGHTDIVTLLLKNGA 758
Score = 142 bits (358), Expect = 3e-33
Identities = 118/405 (29%), Positives = 187/405 (46%), Gaps = 28/405 (6%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
++++S +L+ GA I +T+ N + + + + + V LLL++ A +D + LTP
Sbjct: 284 HVRISEILLDHGAPIQAKTK--NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
L AA G+ + +L K AK + NG L A + H+ V++ L++ ++
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
+ H A+ MG+ IV LL +R + ++ ET L A
Sbjct: 402 ESGLTPLHV-------ASFMGHLPIVKNLL----------QRGASPNVSNVKVETPLHMA 444
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
A G EV + LL+ A V + PL R GH +V LLL + A+ N+A G
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504
Query: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
TPL +AA EGH+ TV LL + AS A M K+G T L A G + V L++ A +
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKK 1221
A KNG TPL +A + + ++V+ L+ G ++G PL A V +LL+
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 1222 GAK--------IGPATWAMATSKPDIMIILLSKLMEEGDMFYKKG 1258
G + P A +++ +LLSK G++ K G
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSG 668
Score = 132 bits (331), Expect = 4e-30
Identities = 110/351 (31%), Positives = 155/351 (44%), Gaps = 34/351 (9%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G E+V L+ +GANV+A S+ G TPL AA +L +V L + A + ++G L
Sbjct: 89 GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
A +GH VV LI K AL AA T + LL
Sbjct: 149 AVALQQGHENVVAHLINYG-----------TKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 1016 KDE----------------EEVERAQIN-------SFDSLWGETALTAAAGRGKLEVCRL 1052
+ E + AQ+ +F G T L A+ RG + + RL
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257
Query: 1053 LLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGH 1112
LL++GA + + PL R GH +I ++LL HGA + K G +P+ MAA H
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 317
Query: 1113 LGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDL 1172
L V LL A I + + LT L A GH V + L+D GA + NG TPL +
Sbjct: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Query: 1173 AAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
A V++ L+ GA I+ V SG+ PL A + +V LL++GA
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428
Score = 130 bits (326), Expect = 2e-29
Identities = 102/342 (29%), Positives = 162/342 (47%), Gaps = 23/342 (6%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+V++ L+ A +N + + + P+ C + +G+T MV LLLE AN + ++ +G TPL
Sbjct: 451 EVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTPLH 508
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCD-WTMAGQQQ 982
AA G++ V+ L +K A + K G L AA G + V + L++ D A +
Sbjct: 509 IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
Query: 983 GVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLW-GETALTAA 1041
G+ L A +IV LL W G T L A
Sbjct: 569 GL--------TPLHVAVHHNNLDIVKLLLPRGGSPHSPA-----------WNGYTPLHIA 609
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
A + ++EV R LL+ G + + +G PL ++GH ++V LLL+ A+ N+ +K G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
TPL + A EGH+ D L+ G + + G T L A G++ +V+ L+ + A +
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1203
K G +PL AA G ++V L+ +GA V G PL
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 61.6 bits (148), Expect = 7e-09
Identities = 43/137 (31%), Positives = 60/137 (43%)
Query: 1093 VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSL 1152
V + T + AA G+L L G I ++ GL L A +GH+ +V L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 1153 VDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNT 1212
+ + K G T L +AA G EVV+ LV++GA + G PL A +
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 1213 SVVVTLLKKGAKIGPAT 1229
VV LL+ GA AT
Sbjct: 125 EVVKFLLENGANQNVAT 141
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 147 bits (372), Expect = 8e-35
Identities = 119/378 (31%), Positives = 184/378 (48%), Gaps = 18/378 (4%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
+++V LL+ GA+I+ TE + L V S +G+ +V LL+ GA+ + S+ TP
Sbjct: 383 HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDW-----T 976
L AA AG+ + L + +AKV+ K+ Q L AA GH +VK L++ + T
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 977 MAGQ-------QQGVFKKSHAIQQALIAAASM---GYTEI-VSYLLDLPEKDEEEVERAQ 1025
AG ++G + A+ + + A M G+T + V+ E +ER
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 1026 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDL 1085
+ G T L A L++ +LLL +G + P G PL +Q ++
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 1086 LLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGH 1145
LL +G N QG TPL +AA EGH V LL++ A+ L +K GLT L +GH
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 1146 LSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDR 1205
+ V L+ +G D + G TPL +A+ YG+ ++V+FL+ H A + G PL +
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 1206 AVGCRNTSVVVTLLKKGA 1223
A +T +V LLK GA
Sbjct: 741 AAQQGHTDIVTLLLKNGA 758
Score = 142 bits (358), Expect = 3e-33
Identities = 118/405 (29%), Positives = 187/405 (46%), Gaps = 28/405 (6%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
++++S +L+ GA I +T+ N + + + + + V LLL++ A +D + LTP
Sbjct: 284 HVRISEILLDHGAPIQAKTK--NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
L AA G+ + +L K AK + NG L A + H+ V++ L++ ++
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
+ H A+ MG+ IV LL +R + ++ ET L A
Sbjct: 402 ESGLTPLHV-------ASFMGHLPIVKNLL----------QRGASPNVSNVKVETPLHMA 444
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
A G EV + LL+ A V + PL R GH +V LLL + A+ N+A G
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504
Query: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
TPL +AA EGH+ TV LL + AS A M K+G T L A G + V L++ A +
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKK 1221
A KNG TPL +A + + ++V+ L+ G ++G PL A V +LL+
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 1222 GAK--------IGPATWAMATSKPDIMIILLSKLMEEGDMFYKKG 1258
G + P A +++ +LLSK G++ K G
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSG 668
Score = 132 bits (331), Expect = 4e-30
Identities = 110/351 (31%), Positives = 155/351 (44%), Gaps = 34/351 (9%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G E+V L+ +GANV+A S+ G TPL AA +L +V L + A + ++G L
Sbjct: 89 GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
A +GH VV LI K AL AA T + LL
Sbjct: 149 AVALQQGHENVVAHLINYG-----------TKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 1016 KDE----------------EEVERAQIN-------SFDSLWGETALTAAAGRGKLEVCRL 1052
+ E + AQ+ +F G T L A+ RG + + RL
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257
Query: 1053 LLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGH 1112
LL++GA + + PL R GH +I ++LL HGA + K G +P+ MAA H
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 317
Query: 1113 LGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDL 1172
L V LL A I + + LT L A GH V + L+D GA + NG TPL +
Sbjct: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Query: 1173 AAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
A V++ L+ GA I+ V SG+ PL A + +V LL++GA
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428
Score = 130 bits (326), Expect = 2e-29
Identities = 102/342 (29%), Positives = 162/342 (47%), Gaps = 23/342 (6%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+V++ L+ A +N + + + P+ C + +G+T MV LLLE AN + ++ +G TPL
Sbjct: 451 EVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTPLH 508
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCD-WTMAGQQQ 982
AA G++ V+ L +K A + K G L AA G + V + L++ D A +
Sbjct: 509 IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
Query: 983 GVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLW-GETALTAA 1041
G+ L A +IV LL W G T L A
Sbjct: 569 GL--------TPLHVAVHHNNLDIVKLLLPRGGSPHSPA-----------WNGYTPLHIA 609
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
A + ++EV R LL+ G + + +G PL ++GH ++V LLL+ A+ N+ +K G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
TPL + A EGH+ D L+ G + + G T L A G++ +V+ L+ + A +
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1203
K G +PL AA G ++V L+ +GA V G PL
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 61.6 bits (148), Expect = 7e-09
Identities = 43/137 (31%), Positives = 60/137 (43%)
Query: 1093 VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSL 1152
V + T + AA G+L L G I ++ GL L A +GH+ +V L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 1153 VDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNT 1212
+ + K G T L +AA G EVV+ LV++GA + G PL A +
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 1213 SVVVTLLKKGAKIGPAT 1229
VV LL+ GA AT
Sbjct: 125 EVVKFLLENGANQNVAT 141
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 147 bits (372), Expect = 8e-35
Identities = 119/378 (31%), Positives = 184/378 (48%), Gaps = 18/378 (4%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
+++V LL+ GA+I+ TE + L V S +G+ +V LL+ GA+ + S+ TP
Sbjct: 383 HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDW-----T 976
L AA AG+ + L + +AKV+ K+ Q L AA GH +VK L++ + T
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 977 MAGQ-------QQGVFKKSHAIQQALIAAASM---GYTEI-VSYLLDLPEKDEEEVERAQ 1025
AG ++G + A+ + + A M G+T + V+ E +ER
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 1026 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDL 1085
+ G T L A L++ +LLL +G + P G PL +Q ++
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 1086 LLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGH 1145
LL +G N QG TPL +AA EGH V LL++ A+ L +K GLT L +GH
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 1146 LSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDR 1205
+ V L+ +G D + G TPL +A+ YG+ ++V+FL+ H A + G PL +
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 1206 AVGCRNTSVVVTLLKKGA 1223
A +T +V LLK GA
Sbjct: 741 AAQQGHTDIVTLLLKNGA 758
Score = 142 bits (358), Expect = 3e-33
Identities = 118/405 (29%), Positives = 187/405 (46%), Gaps = 28/405 (6%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
++++S +L+ GA I +T+ N + + + + + V LLL++ A +D + LTP
Sbjct: 284 HVRISEILLDHGAPIQAKTK--NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
L AA G+ + +L K AK + NG L A + H+ V++ L++ ++
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
+ H A+ MG+ IV LL +R + ++ ET L A
Sbjct: 402 ESGLTPLHV-------ASFMGHLPIVKNLL----------QRGASPNVSNVKVETPLHMA 444
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
A G EV + LL+ A V + PL R GH +V LLL + A+ N+A G
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504
Query: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
TPL +AA EGH+ TV LL + AS A M K+G T L A G + V L++ A +
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKK 1221
A KNG TPL +A + + ++V+ L+ G ++G PL A V +LL+
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 1222 GAK--------IGPATWAMATSKPDIMIILLSKLMEEGDMFYKKG 1258
G + P A +++ +LLSK G++ K G
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSG 668
Score = 132 bits (331), Expect = 4e-30
Identities = 110/351 (31%), Positives = 155/351 (44%), Gaps = 34/351 (9%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G E+V L+ +GANV+A S+ G TPL AA +L +V L + A + ++G L
Sbjct: 89 GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
A +GH VV LI K AL AA T + LL
Sbjct: 149 AVALQQGHENVVAHLINYG-----------TKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 1016 KDE----------------EEVERAQIN-------SFDSLWGETALTAAAGRGKLEVCRL 1052
+ E + AQ+ +F G T L A+ RG + + RL
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257
Query: 1053 LLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGH 1112
LL++GA + + PL R GH +I ++LL HGA + K G +P+ MAA H
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 317
Query: 1113 LGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDL 1172
L V LL A I + + LT L A GH V + L+D GA + NG TPL +
Sbjct: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Query: 1173 AAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
A V++ L+ GA I+ V SG+ PL A + +V LL++GA
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428
Score = 130 bits (326), Expect = 2e-29
Identities = 102/342 (29%), Positives = 162/342 (47%), Gaps = 23/342 (6%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+V++ L+ A +N + + + P+ C + +G+T MV LLLE AN + ++ +G TPL
Sbjct: 451 EVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTPLH 508
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCD-WTMAGQQQ 982
AA G++ V+ L +K A + K G L AA G + V + L++ D A +
Sbjct: 509 IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
Query: 983 GVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLW-GETALTAA 1041
G+ L A +IV LL W G T L A
Sbjct: 569 GL--------TPLHVAVHHNNLDIVKLLLPRGGSPHSPA-----------WNGYTPLHIA 609
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
A + ++EV R LL+ G + + +G PL ++GH ++V LLL+ A+ N+ +K G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
TPL + A EGH+ D L+ G + + G T L A G++ +V+ L+ + A +
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1203
K G +PL AA G ++V L+ +GA V G PL
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 61.6 bits (148), Expect = 7e-09
Identities = 43/137 (31%), Positives = 60/137 (43%)
Query: 1093 VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSL 1152
V + T + AA G+L L G I ++ GL L A +GH+ +V L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 1153 VDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNT 1212
+ + K G T L +AA G EVV+ LV++GA + G PL A +
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 1213 SVVVTLLKKGAKIGPAT 1229
VV LL+ GA AT
Sbjct: 125 EVVKFLLENGANQNVAT 141
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 147 bits (372), Expect = 8e-35
Identities = 119/378 (31%), Positives = 184/378 (48%), Gaps = 18/378 (4%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
+++V LL+ GA+I+ TE + L V S +G+ +V LL+ GA+ + S+ TP
Sbjct: 383 HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDW-----T 976
L AA AG+ + L + +AKV+ K+ Q L AA GH +VK L++ + T
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 977 MAGQ-------QQGVFKKSHAIQQALIAAASM---GYTEI-VSYLLDLPEKDEEEVERAQ 1025
AG ++G + A+ + + A M G+T + V+ E +ER
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 1026 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDL 1085
+ G T L A L++ +LLL +G + P G PL +Q ++
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 1086 LLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGH 1145
LL +G N QG TPL +AA EGH V LL++ A+ L +K GLT L +GH
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 1146 LSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDR 1205
+ V L+ +G D + G TPL +A+ YG+ ++V+FL+ H A + G PL +
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 1206 AVGCRNTSVVVTLLKKGA 1223
A +T +V LLK GA
Sbjct: 741 AAQQGHTDIVTLLLKNGA 758
Score = 142 bits (358), Expect = 3e-33
Identities = 118/405 (29%), Positives = 187/405 (46%), Gaps = 28/405 (6%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
++++S +L+ GA I +T+ N + + + + + V LLL++ A +D + LTP
Sbjct: 284 HVRISEILLDHGAPIQAKTK--NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
L AA G+ + +L K AK + NG L A + H+ V++ L++ ++
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
+ H A+ MG+ IV LL +R + ++ ET L A
Sbjct: 402 ESGLTPLHV-------ASFMGHLPIVKNLL----------QRGASPNVSNVKVETPLHMA 444
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
A G EV + LL+ A V + PL R GH +V LLL + A+ N+A G
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504
Query: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
TPL +AA EGH+ TV LL + AS A M K+G T L A G + V L++ A +
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKK 1221
A KNG TPL +A + + ++V+ L+ G ++G PL A V +LL+
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 1222 GAK--------IGPATWAMATSKPDIMIILLSKLMEEGDMFYKKG 1258
G + P A +++ +LLSK G++ K G
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSG 668
Score = 132 bits (331), Expect = 4e-30
Identities = 110/351 (31%), Positives = 155/351 (44%), Gaps = 34/351 (9%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G E+V L+ +GANV+A S+ G TPL AA +L +V L + A + ++G L
Sbjct: 89 GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
A +GH VV LI K AL AA T + LL
Sbjct: 149 AVALQQGHENVVAHLINYG-----------TKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 1016 KDE----------------EEVERAQIN-------SFDSLWGETALTAAAGRGKLEVCRL 1052
+ E + AQ+ +F G T L A+ RG + + RL
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257
Query: 1053 LLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGH 1112
LL++GA + + PL R GH +I ++LL HGA + K G +P+ MAA H
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 317
Query: 1113 LGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDL 1172
L V LL A I + + LT L A GH V + L+D GA + NG TPL +
Sbjct: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Query: 1173 AAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
A V++ L+ GA I+ V SG+ PL A + +V LL++GA
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428
Score = 130 bits (326), Expect = 2e-29
Identities = 102/342 (29%), Positives = 162/342 (47%), Gaps = 23/342 (6%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
+V++ L+ A +N + + + P+ C + +G+T MV LLLE AN + ++ +G TPL
Sbjct: 451 EVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTPLH 508
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCD-WTMAGQQQ 982
AA G++ V+ L +K A + K G L AA G + V + L++ D A +
Sbjct: 509 IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
Query: 983 GVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLW-GETALTAA 1041
G+ L A +IV LL W G T L A
Sbjct: 569 GL--------TPLHVAVHHNNLDIVKLLLPRGGSPHSPA-----------WNGYTPLHIA 609
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
A + ++EV R LL+ G + + +G PL ++GH ++V LLL+ A+ N+ +K G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
Query: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
TPL + A EGH+ D L+ G + + G T L A G++ +V+ L+ + A +
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1203
K G +PL AA G ++V L+ +GA V G PL
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 61.6 bits (148), Expect = 7e-09
Identities = 43/137 (31%), Positives = 60/137 (43%)
Query: 1093 VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSL 1152
V + T + AA G+L L G I ++ GL L A +GH+ +V L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 1153 VDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNT 1212
+ + K G T L +AA G EVV+ LV++GA + G PL A +
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 1213 SVVVTLLKKGAKIGPAT 1229
VV LL+ GA AT
Sbjct: 125 EVVKFLLENGANQNVAT 141
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 142 bits (357), Expect = 4e-33
Identities = 113/353 (32%), Positives = 168/353 (47%), Gaps = 28/353 (7%)
Query: 859 YTPNIKVSRLLILGGANINYRTEV----LNNAPILCVQSHLGYTEMVALLLEFGANVDAS 914
Y + ++ LLIL GA +N + L+ A C + E V +LL+ A+V+A
Sbjct: 50 YLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSE------EAVQVLLKHSADVNAR 103
Query: 915 SESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCD 974
++ TPL AAA + L + V+ D+ G+ AL HAA GH E+VK L+
Sbjct: 104 DKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS-- 161
Query: 975 WTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWG 1034
G F K ++A+ AA MG+ E+V L+ A++ D
Sbjct: 162 ---RGANINAFDKKD--RRAIHWAAYMGHIEVVKLLVS---------HGAEVTCKDKK-S 206
Query: 1035 ETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVN 1094
T L AAA G + V + LL+ G + +PN G PL G +V+ L+ GA VN
Sbjct: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
Query: 1095 MADKQGRTPLMMAASEGHLG-TVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLV 1153
+++G TPL AA+ H ++ L+ GA + + K+G T L L G S ++++
Sbjct: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326
Query: 1154 DNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1206
+GA D DKNG TPL +AA YG ++ L+ GA GM PL A
Sbjct: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLA 379
Score = 127 bits (319), Expect = 1e-28
Identities = 110/351 (31%), Positives = 155/351 (44%), Gaps = 51/351 (14%)
Query: 909 ANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVK 968
+NV+ S +G T L +AA +G+ +V LL + A ++ DK + A+ AA GH+EVVK
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
Query: 969 FLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS 1028
L+ + + KKS+ L AAAS G +V YLLDL V+ + N+
Sbjct: 191 LLVSHGAEVTCKD----KKSYT---PLHAAASSGMISVVKYLLDLG------VDMNEPNA 237
Query: 1029 FDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQI-VDLLL 1087
+ G T L A G+ V L++ GA V Q N +G PL H + ++LL+
Sbjct: 238 Y----GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLV 293
Query: 1088 THGADVNMA---------------------------------DKQGRTPLMMAASEGHLG 1114
+GADVNM DK G TPL +AA GH
Sbjct: 294 GNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHEL 353
Query: 1115 TVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAA 1174
++ L+ GA A G+ L A L G R L+ +G D D GRT L AA
Sbjct: 354 LINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAA 413
Query: 1175 FYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1225
G+ E + L++ GA D G PL A N + L+ GA +
Sbjct: 414 AGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASV 464
Score = 127 bits (319), Expect = 1e-28
Identities = 108/376 (28%), Positives = 167/376 (44%), Gaps = 55/376 (14%)
Query: 889 LCVQSHLGYTEMVALLLEFGANV--DASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDH 946
LC+Q T + L+ G ++ D+ + + ++PL AA G+ + +L + +D
Sbjct: 519 LCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDV 578
Query: 947 LDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALI-AAASMGYTE 1005
+ +G+ L AA +GH+E V LI Q + K + +++ I AAA+ G++E
Sbjct: 579 RNSSGRTPLDLAAFKGHVECVDVLIN-------QGASILVKDYILKRTPIHAAATNGHSE 631
Query: 1006 IVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNR 1065
+ L+ E + V+ N G+T L + G + LL +GA V ++
Sbjct: 632 CLRLLIGNAEP-QNAVDIQDGN------GQTPLMLSVLNGHTDCVYSLLNKGANVDAKDK 684
Query: 1066 RGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGAS 1125
G L GH + VD LL HGA + D +GRTP+ ++A+ GH+G + LL AS
Sbjct: 685 WGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAAS 744
Query: 1126 I----ALMDKEGLTALSWACLKGHLSVVRSLVDN-----------------------GAA 1158
+ A D G TAL WAC GH + V L++ GAA
Sbjct: 745 MDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAA 804
Query: 1159 -----------TDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAV 1207
+ D GRTPL AAF E +Q L+ H A + VD +G PL A
Sbjct: 805 EMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAA 864
Query: 1208 GCRNTSVVVTLLKKGA 1223
T+ V L+ +
Sbjct: 865 ENGQTNTVEMLVSSAS 880
Score = 112 bits (280), Expect = 4e-24
Identities = 99/340 (29%), Positives = 149/340 (43%), Gaps = 18/340 (5%)
Query: 867 RLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAA 926
+LL+ GANIN + A + +++G+ E+V LL+ GA V + TPL AA
Sbjct: 157 KLLLSRGANINAFDKKDRRA--IHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAA 214
Query: 927 AAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFK 986
++G +S+V L ++ + G L A G VV LI C + + + F
Sbjct: 215 SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274
Query: 987 KSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGK 1046
H AAAS + L+ A +N S G+T L A G+
Sbjct: 275 PLH------FAAASTHGALCLELLVG---------NGADVN-MKSKDGKTPLHMTALHGR 318
Query: 1047 LEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMM 1106
+ +++ GA + ++ G PL R GH +++ L+T GAD G PL +
Sbjct: 319 FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHL 378
Query: 1107 AASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNG 1166
AA G LL+ G I D G T L A G+L + L++ GA + DK G
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438
Query: 1167 RTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1206
R+PL AA + + + LV GA + +D G PL A
Sbjct: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478
Score = 111 bits (277), Expect = 8e-24
Identities = 101/315 (32%), Positives = 145/315 (46%), Gaps = 24/315 (7%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G+T+ V LL GANVDA + G T L A G+ V L + AK D G+ +
Sbjct: 664 GHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPI 723
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
+A GH+ V+ L+Q +M + AL A G+ V LL+
Sbjct: 724 HLSAACGHIGVLGALLQSAASMDANPATADNHGYT---ALHWACYNGHETCVELLLE--- 777
Query: 1016 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQP-NRRGAVPLFST 1074
+E ++ + N+F L G E+ L+ GA++ + +G PL +
Sbjct: 778 --QEVFQKTEGNAFSPLH---CAVINDNEGAAEM--LIDTLGASIVNATDSKGRTPLHAA 830
Query: 1075 VRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQ-GASIALMDKEG 1133
H + + LLL+H A VN D G+TPLMMAA G TV+ L++ A + L D
Sbjct: 831 AFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK 890
Query: 1134 LTALSWACLKGH----LSVVRSLVDNGA--ATDHADKNGRTPLDLAAFYGDAEVVQFLVD 1187
TAL AC KGH L ++ + D AT+ A +TPL +AA G VVQ L+
Sbjct: 891 NTALHLACSKGHETSALLILEKITDRNLINATNAA---LQTPLHVAARNGLTMVVQELLG 947
Query: 1188 HGAMIEHVDYSGMRP 1202
GA + VD +G P
Sbjct: 948 KGASVLAVDENGYTP 962
Score = 102 bits (255), Expect = 3e-21
Identities = 96/318 (30%), Positives = 147/318 (46%), Gaps = 29/318 (9%)
Query: 952 QCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLL 1011
Q +LV A G + V+ LI +++ V + + + L AAA +G EI+ L+
Sbjct: 9 QPSLVQAIFNGDPDEVRALIF-------KKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI 61
Query: 1012 DLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPL 1071
+ A++N+ DS W T L A E ++LL+ A V ++ PL
Sbjct: 62 ---------LSGARVNAKDSKW-LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPL 111
Query: 1072 FSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDK 1131
+ + L+ ++VN++D+ GRT L AA GH V LL++GA+I DK
Sbjct: 112 HIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDK 171
Query: 1132 EGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAM 1191
+ A+ WA GH+ VV+ LV +GA DK TPL AA G VV++L+D G
Sbjct: 172 KDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVD 231
Query: 1192 IEHVDYSGMRPLDRAVGCRNTSVVVT--LLKKGAKIG--------PATWAMATSKPDIMI 1241
+ + G PL V C N VV L+ GA + P +A A++ + +
Sbjct: 232 MNEPNAYGNTPLH--VACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCL 289
Query: 1242 ILLSKLMEEGDMFYKKGK 1259
LL + +M K GK
Sbjct: 290 ELLVGNGADVNMKSKDGK 307
Score = 102 bits (254), Expect = 4e-21
Identities = 83/280 (29%), Positives = 128/280 (45%), Gaps = 17/280 (6%)
Query: 940 KRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAA 999
K+ V+ D + L AA G E+++ LI ++G + K S + A A
Sbjct: 30 KKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI-----LSGARVNA-KDSKWLTPLHRAVA 83
Query: 1000 SMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAA 1059
S E V LL A +N+ D W +T L AA ++ L+ +
Sbjct: 84 SCS-EEAVQVLLK---------HSADVNARDKNW-QTPLHIAAANKAVKCAEALVPLLSN 132
Query: 1060 VAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFL 1119
V +R G L GH ++V LLL+ GA++N DK+ R + AA GH+ V L
Sbjct: 133 VNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL 192
Query: 1120 LAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDA 1179
++ GA + DK+ T L A G +SVV+ L+D G + + G TPL +A + G
Sbjct: 193 VSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQD 252
Query: 1180 EVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219
VV L+D GA++ + G PL A + ++ + LL
Sbjct: 253 VVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 292
Score = 100 bits (249), Expect = 1e-20
Identities = 115/406 (28%), Positives = 171/406 (42%), Gaps = 41/406 (10%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
N++ LL+ GA+ N + + +P+ ++ Y + AL+ GA+V+ E G TP
Sbjct: 417 NLECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQCLFALVGS-GASVNDLDERGCTP 474
Query: 922 LGYAAAAGYLS-IVVLLCKKRAKVDHLDKNGQCALVHAALRGH---LEVVKFLIQCDWTM 977
L YAA + + L + A DK G A+ ++A GH L+++ D M
Sbjct: 475 LHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLM 534
Query: 978 AGQQQGVFKKS--HAIQQALIAAASMGYTE----IVSYLLDLPEKDEEEVERAQINSF-- 1029
+ S A L AA G+ + +V LLDL ++ + +F
Sbjct: 535 ETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKG 594
Query: 1030 ------------------DSLWGETALTAAAGRGKLEVCRLLL---EQGAAVAQPNRRGA 1068
D + T + AAA G E RLL+ E AV + G
Sbjct: 595 HVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQ 654
Query: 1069 VPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL 1128
PL +V GH V LL GA+V+ DK GRT L A GH VD LL GA L
Sbjct: 655 TPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLL 714
Query: 1129 MDKEGLTALSWACLKGHLSVVRSLVDNGAATD----HADKNGRTPLDLAAFYGDAEVVQF 1184
D G T + + GH+ V+ +L+ + A+ D AD +G T L A + G V+
Sbjct: 715 RDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVEL 774
Query: 1185 LVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKK-GAKIGPAT 1229
L++ + + + + PL AV N L+ GA I AT
Sbjct: 775 LLEQ-EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNAT 819
Score = 90.9 bits (224), Expect = 1e-17
Identities = 101/367 (27%), Positives = 146/367 (39%), Gaps = 71/367 (19%)
Query: 903 LLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRG 962
LL+ GA+V+ S+ G TPL A G S + + A +D DKNG L AA G
Sbjct: 291 LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYG 350
Query: 963 HLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLL----DLPEKDE 1018
H ++ LI A ++G+ H + +AA S G+++ LL D+ D+
Sbjct: 351 HELLINTLITSGADTA--KRGI----HGMFPLHLAALS-GFSDCCRKLLSSGFDIDTPDD 403
Query: 1019 EEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQG 1078
+G T L AAA G LE LLL GA + ++ G PL
Sbjct: 404 --------------FGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANC 449
Query: 1079 HWQIVDLLLTHGADVN----------------------------------MADKQGRTPL 1104
++Q + L+ GA VN + DKQG +
Sbjct: 450 NYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAV 509
Query: 1105 MMAASEGHLGTVDFLLAQGASIALMDKEG------------LTALSWACLKGHLSVVRSL 1152
+A+ GH + + ++ LM+ G ++ L A GH + L
Sbjct: 510 HYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVL 569
Query: 1153 VDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNT 1212
V + D + +GRTPLDLAAF G E V L++ GA I DY R A
Sbjct: 570 VQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGH 629
Query: 1213 SVVVTLL 1219
S + LL
Sbjct: 630 SECLRLL 636
Score = 77.0 bits (188), Expect = 2e-13
Identities = 64/228 (28%), Positives = 94/228 (41%), Gaps = 33/228 (14%)
Query: 1028 SFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLL- 1086
+F L + +L A G + R L+ + V + PL + G +I++LL
Sbjct: 2 AFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI 61
Query: 1087 --------------------------------LTHGADVNMADKQGRTPLMMAASEGHLG 1114
L H ADVN DK +TPL +AA+ +
Sbjct: 62 LSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVK 121
Query: 1115 TVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAA 1174
+ L+ +++ + D+ G TAL A GH +V+ L+ GA + DK R + AA
Sbjct: 122 CAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAA 181
Query: 1175 FYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKG 1222
+ G EVV+ LV HGA + D PL A SVV LL G
Sbjct: 182 YMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLG 229
Score = 48.1 bits (113), Expect = 8e-05
Identities = 65/282 (23%), Positives = 94/282 (33%), Gaps = 80/282 (28%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDH----LDKNG 951
G+ E V LL+ GA G TP+ +AA G++ ++ L + A +D D +G
Sbjct: 697 GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG 756
Query: 952 QCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAI-------------------- 991
AL A GH V+ L++ + + F H
Sbjct: 757 YTALHWACYNGHETCVELLLEQE-VFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASI 815
Query: 992 --------QQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAG 1043
+ L AAA + E + LL AQ+NS DS G+T L AA
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLLS---------HNAQVNSVDST-GKTPLMMAAE 865
Query: 1044 RGKLEVCRLLLEQGAA--VAQPNRRGAV-------------------------------- 1069
G+ +L+ +A Q N +
Sbjct: 866 NGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAA 925
Query: 1070 ---PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAA 1108
PL R G +V LL GA V D+ G TP + A
Sbjct: 926 LQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapiens]
Length = 1771
Score = 140 bits (352), Expect = 2e-32
Identities = 116/369 (31%), Positives = 166/369 (44%), Gaps = 41/369 (11%)
Query: 888 ILCVQSHLGYTE-----MVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRA 942
+L QS + Y E + LLE +VD +E G TPL AA G L IV L K A
Sbjct: 3 VLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGA 62
Query: 943 KVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKK--------------- 987
+ D + AL+ A+ GH+ +V+ L++C + + G +
Sbjct: 63 NCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVEL 122
Query: 988 --SHAIQQA---------LIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGET 1036
SH + +I AA G+ +IV LL A++N D +G T
Sbjct: 123 LLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQ---------NGAKVNCSDK-YGTT 172
Query: 1037 ALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMA 1096
L AA +G LE + LL GA V Q L V+ G+ Q V +L +VN+
Sbjct: 173 PLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLT 232
Query: 1097 DKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNG 1156
DK G T LM+A+ EGH V LL G + + D+ G T L A GH+ +VR+L+
Sbjct: 233 DKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKY 292
Query: 1157 AATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVV 1216
A D ++ +T L A G+A +V+ ++ E G PL +A RN VV
Sbjct: 293 ADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVE 352
Query: 1217 TLLKKGAKI 1225
LL KGAK+
Sbjct: 353 LLLDKGAKV 361
Score = 80.5 bits (197), Expect = 2e-14
Identities = 76/268 (28%), Positives = 116/268 (43%), Gaps = 41/268 (15%)
Query: 865 VSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGY 924
+ LL+ GA +N ++ P++ + G+ E V LL GA+VD + +T L
Sbjct: 152 IVHLLLQNGAKVNC-SDKYGTTPLVWA-ARKGHLECVKHLLAMGADVDQEGANSMTALIV 209
Query: 925 AAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGV 984
A GY V + K+ V+ DK+G AL+ A+ GH E+V+ L+ AG +
Sbjct: 210 AVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD-----AGTYVNI 264
Query: 985 FKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLW----------- 1033
+S LI A G+ EIV LL +K + R Q N W
Sbjct: 265 PDRSG--DTVLIGAVRGGHVEIVRALL---QKYADIDIRGQDNKTALYWAVEKGNATMVR 319
Query: 1034 ---------------GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQG 1078
GET L A +EV LLL++GA V+ +++G PL +R
Sbjct: 320 DILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGR 379
Query: 1079 HWQIVDLLLTHGADVNM---ADKQGRTP 1103
++ +LLL + D + +K G TP
Sbjct: 380 SRKLAELLLRNPKDGRLLYRPNKAGETP 407
Score = 52.0 bits (123), Expect = 6e-06
Identities = 42/143 (29%), Positives = 64/143 (44%), Gaps = 8/143 (5%)
Query: 1110 EGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTP 1169
E ++ + LL + + ++ G T L A +G+L +V+ L+ NGA + D + T
Sbjct: 15 EENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTA 74
Query: 1170 LDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA------ 1223
L A+ G +V+ L+ G +EH D G L A T VV LL GA
Sbjct: 75 LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTG 134
Query: 1224 --KIGPATWAMATSKPDIMIILL 1244
+ P WA DI+ +LL
Sbjct: 135 LYSVYPIIWAAGRGHADIVHLLL 157
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 136 bits (342), Expect = 2e-31
Identities = 96/301 (31%), Positives = 144/301 (47%), Gaps = 25/301 (8%)
Query: 910 NVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKF 969
+V+ ++ G PL AA G + I+ LL K+ +++D DK G A+ AA GH++ +KF
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 970 LIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE----KDEEEVERAQ 1025
L + + + K + + AL AA G+ ++ L +D+EE
Sbjct: 431 LSE-------NKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE----- 478
Query: 1026 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDL 1085
ET L AA G V + L E G V NR G PL + +G+ IV+
Sbjct: 479 ---------ETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC 529
Query: 1086 LLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGH 1145
L HGAD+N DK G L +A + + LL+QG + D+ G T L AC G+
Sbjct: 530 LAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGN 589
Query: 1146 LSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDR 1205
+ +V +L + D ++K GRTPL LAA G +VV++L GA +E + G D
Sbjct: 590 MPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDL 649
Query: 1206 A 1206
A
Sbjct: 650 A 650
Score = 92.4 bits (228), Expect = 4e-18
Identities = 62/231 (26%), Positives = 103/231 (44%), Gaps = 10/231 (4%)
Query: 995 LIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLL 1054
L+ AA G +I+ L ++R G A+ AA G ++ + L
Sbjct: 383 LLIAAGCGNIQILQLL----------IKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLS 432
Query: 1055 EQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLG 1114
E + ++ G + L R GH + LL + G++ N+ DK+ TPL AA G+
Sbjct: 433 ENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYS 492
Query: 1115 TVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAA 1174
L G ++ + ++EG T L A +G+ +V L ++GA + DK+G L LA
Sbjct: 493 VAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAV 552
Query: 1175 FYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1225
EV++ L+ G +++ D G PL A N +VV L + +
Sbjct: 553 RRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNL 603
Score = 91.7 bits (226), Expect = 7e-18
Identities = 56/189 (29%), Positives = 95/189 (50%)
Query: 1034 GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADV 1093
G L AAG G +++ +LL+++G+ + ++ G+ ++ R GH + L + +
Sbjct: 379 GTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPL 438
Query: 1094 NMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLV 1153
++ DK G L +AA GH L + G++ + DKE T L A G+ SV ++L
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALC 498
Query: 1154 DNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTS 1213
+ G + ++ G TPL A+ G ++V+ L +HGA + D G L AV
Sbjct: 499 EAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQME 558
Query: 1214 VVVTLLKKG 1222
V+ TLL +G
Sbjct: 559 VIKTLLSQG 567
Score = 87.4 bits (215), Expect = 1e-16
Identities = 69/257 (26%), Positives = 110/257 (42%), Gaps = 50/257 (19%)
Query: 889 LCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLD 948
L V + G+ ++ LL FG+N + + TPL AA GY S+ LC+ V+ +
Sbjct: 449 LHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN 508
Query: 949 KNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVS 1008
+ G+ L+ A+ RG+ ++V+ L +
Sbjct: 509 REGETPLLTASARGYHDIVECLAE------------------------------------ 532
Query: 1009 YLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGA 1068
A +N+ D G AL A R ++EV + LL QG V +R G
Sbjct: 533 -------------HGADLNACDK-DGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGN 578
Query: 1069 VPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL 1128
PL + G+ IV L ++++++K GRTPL +AA+ G L V +L GAS+
Sbjct: 579 TPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEA 638
Query: 1129 MDKEGLTALSWACLKGH 1145
+ +G TA A + H
Sbjct: 639 LTTDGKTAEDLARSEQH 655
Score = 75.9 bits (185), Expect = 4e-13
Identities = 45/134 (33%), Positives = 66/134 (49%)
Query: 1092 DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRS 1151
DVN +K G PL++AA G++ + L+ +G+ I + DK G A+ WA GH+ ++
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 1152 LVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRN 1211
L +N D DK+G L +AA YG A+V Q L G+ D PL A
Sbjct: 431 LSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGY 490
Query: 1212 TSVVVTLLKKGAKI 1225
SV L + G +
Sbjct: 491 YSVAKALCEAGCNV 504
Score = 63.9 bits (154), Expect = 1e-09
Identities = 65/248 (26%), Positives = 90/248 (36%), Gaps = 52/248 (20%)
Query: 865 VSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGY 924
V++LL G+N N + + P+ C H GY + L E G NV+ + G TPL
Sbjct: 460 VAQLLCSFGSNPNIQDKE-EETPLHCAAWH-GYYSVAKALCEAGCNVNIKNREGETPLLT 517
Query: 925 AAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGV 984
A+A GY IV L + A ++ DK+G AL A R +EV+K L+ QG
Sbjct: 518 ASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL---------SQGC 568
Query: 985 FKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGR 1044
F + G T L A
Sbjct: 569 FV-----------------------------------------DYQDRHGNTPLHVACKD 587
Query: 1045 GKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPL 1104
G + + L E + N+ G PL G +V L GA V G+T
Sbjct: 588 GNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAE 647
Query: 1105 MMAASEGH 1112
+A SE H
Sbjct: 648 DLARSEQH 655
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 135 bits (340), Expect = 4e-31
Identities = 120/414 (28%), Positives = 186/414 (44%), Gaps = 28/414 (6%)
Query: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
++ LLIL GA +N + + V S E V +L++ A+V+A ++ TPL
Sbjct: 30 EIIELLILSGARVNAKDNMWLTPLHRAVASRS--EEAVQVLIKHSADVNARDKNWQTPLH 87
Query: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983
AAA + ++ + V+ D+ G+ AL HAAL GH+E+V L+ G
Sbjct: 88 VAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL-----AKGANIN 142
Query: 984 VFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAG 1043
F K ++AL AA MG+ ++V+ L++ A++ D G T L AAA
Sbjct: 143 AFDKKD--RRALHWAAYMGHLDVVALLIN---------HGAEVTCKDKK-GYTPLHAAAS 190
Query: 1044 RGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTP 1103
G++ V + LL G + + N G L G +V+ L+ +GA+VN + G TP
Sbjct: 191 NGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTP 250
Query: 1104 LMMAASEGHLG-TVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHA 1162
L AA+ H ++ L+ GA + + K+G + L + G + ++L+ NG D
Sbjct: 251 LHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV 310
Query: 1163 DKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKG 1222
DK+G TPL +AA YG ++ L GA M PL A ++ LL G
Sbjct: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG 370
Query: 1223 ------AKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRYQYA 1270
K G A + ++ I L L G F+KK K Y A
Sbjct: 371 FEIDTPDKFGRTCLHAAAAGGNVECIKL--LQSSGADFHKKDKCGRTPLHYAAA 422
Score = 111 bits (277), Expect = 8e-24
Identities = 99/345 (28%), Positives = 148/345 (42%), Gaps = 18/345 (5%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
++++ LL+ GANIN + A L +++G+ ++VALL+ GA V + G TP
Sbjct: 127 HVEMVNLLLAKGANINAFDKKDRRA--LHWAAYMGHLDVVALLINHGAEVTCKDKKGYTP 184
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
L AA+ G +++V L ++D ++ G AL A G VV LI +
Sbjct: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
F H AAAS + L++ A +N S G++ L
Sbjct: 245 NNGFTPLH------FAAASTHGALCLELLVN---------NGADVN-IQSKDGKSPLHMT 288
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
A G+ + L++ G + ++ G PL R GH +++ L T GAD
Sbjct: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM 348
Query: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
PL +AA H LL+ G I DK G T L A G++ ++ L +GA
Sbjct: 349 FPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHK 408
Query: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1206
DK GRTPL AA ++ LV GA + D G L A
Sbjct: 409 KDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453
Score = 109 bits (273), Expect = 2e-23
Identities = 100/349 (28%), Positives = 148/349 (42%), Gaps = 56/349 (16%)
Query: 896 GYTEMVALLLEFGANVDASSESGLT--PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQC 953
G+ + + LLLE + S+SG T PL AA G+ + +L + +D D+ G+
Sbjct: 518 GHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRT 577
Query: 954 ALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQA-LIAAASMGYTEIVSYLLD 1012
AL AA +GH E V+ LI +F K + ++ L A+ G+T + LL+
Sbjct: 578 ALDLAAFKGHTECVEALIN-------PGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
Query: 1013 LPEKDEE-EVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPL 1071
+ + E +V+ A+ G+T L A G ++ LLLE+ A V + G L
Sbjct: 631 IADNPEAVDVKDAK--------GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTAL 682
Query: 1072 FSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGAS---IAL 1128
+ GH + V +LL + D +GRTPL AA+ GH + LL S
Sbjct: 683 HRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCF 742
Query: 1129 MDKEGLTALSWACLKGHLSVVRSLVDN----------------GAATDHA---------- 1162
D +G T L WAC G+ + + L++ DH
Sbjct: 743 KDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAI 802
Query: 1163 --------DKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1203
D GRTPL AAF E +Q L+ H A + VD SG L
Sbjct: 803 DSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTAL 851
Score = 108 bits (270), Expect = 5e-23
Identities = 83/284 (29%), Positives = 132/284 (46%), Gaps = 17/284 (5%)
Query: 936 LLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQAL 995
+L K V+ LD + L AA G E+++ LI ++G + V K + L
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLI-----LSGAR--VNAKDNMWLTPL 53
Query: 996 IAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLE 1055
A + E V L+ A +N+ D W +T L AA ++ +++
Sbjct: 54 HRAVASRSEEAVQVLIK---------HSADVNARDKNW-QTPLHVAAANKAVKCAEVIIP 103
Query: 1056 QGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGT 1115
++V +R G L GH ++V+LLL GA++N DK+ R L AA GHL
Sbjct: 104 LLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDV 163
Query: 1116 VDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAF 1175
V L+ GA + DK+G T L A G ++VV+ L++ G D + G T L +A +
Sbjct: 164 VALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACY 223
Query: 1176 YGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219
G VV L+D+GA + + +G PL A + ++ + LL
Sbjct: 224 NGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL 267
Score = 107 bits (267), Expect = 1e-22
Identities = 74/231 (32%), Positives = 116/231 (50%), Gaps = 10/231 (4%)
Query: 995 LIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLL 1054
L AA +G EI+ L+ + A++N+ D++W A A R + E ++L+
Sbjct: 20 LHVAAFLGDAEIIELLI---------LSGARVNAKDNMWLTPLHRAVASRSE-EAVQVLI 69
Query: 1055 EQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLG 1114
+ A V ++ PL + ++++ + VN++D+ GRT L AA GH+
Sbjct: 70 KHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVE 129
Query: 1115 TVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAA 1174
V+ LLA+GA+I DK+ AL WA GHL VV L+++GA DK G TPL AA
Sbjct: 130 MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAA 189
Query: 1175 FYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1225
G VV+ L++ G I+ ++ G L A +VV L+ GA +
Sbjct: 190 SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
Score = 106 bits (265), Expect = 2e-22
Identities = 104/375 (27%), Positives = 157/375 (41%), Gaps = 36/375 (9%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G E + LL GA+ + G TPL YAAA + + L A V+ D G+ AL
Sbjct: 391 GNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTAL 450
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
+AA + + + +H + L A + E L L +
Sbjct: 451 HYAAASD---------------MDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQ 495
Query: 1016 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAV--PLFS 1073
D S G ++ AA G + LLLE+ + + + GA PL
Sbjct: 496 NDANP-------SIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHL 548
Query: 1074 TVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDK-E 1132
GH Q +++LL D+++ D++GRT L +AA +GH V+ L+ GASI + D
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
Query: 1133 GLTALSWACLKGHLSVVRSLV---DNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHG 1189
T L + + GH +R L+ DN A D D G+TPL LA YG + V L++
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
Query: 1190 AMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI--------GPATWAMATSKPDIMI 1241
A ++ VD G L R + + V LL++ I P +A A +
Sbjct: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728
Query: 1242 ILLSKLMEEGDMFYK 1256
LL + E D +K
Sbjct: 729 ELLQMALSEEDCCFK 743
Score = 104 bits (259), Expect = 1e-21
Identities = 69/200 (34%), Positives = 99/200 (49%), Gaps = 1/200 (0%)
Query: 1026 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDL 1085
+N+ DS T L AA G E+ LL+ GA V + PL V + V +
Sbjct: 9 VNTLDSE-KRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 1086 LLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGH 1145
L+ H ADVN DK +TPL +AA+ + + ++ +S+ + D+ G TAL A L GH
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
Query: 1146 LSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDR 1205
+ +V L+ GA + DK R L AA+ G +VV L++HGA + D G PL
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHA 187
Query: 1206 AVGCRNTSVVVTLLKKGAKI 1225
A +VV LL G +I
Sbjct: 188 AASNGQINVVKHLLNLGVEI 207
Score = 99.0 bits (245), Expect = 4e-20
Identities = 99/328 (30%), Positives = 138/328 (42%), Gaps = 28/328 (8%)
Query: 869 LILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGAN---VDASSESGLTPLGYA 925
LI GA+I + V P+ + G+T + LLLE N VD G TPL A
Sbjct: 594 LINPGASIFVKDNVTKRTPLHASVIN-GHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLA 652
Query: 926 AAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVF 985
A G++ V LL +K A VD +D G AL + GH E V+ L++ Q+ +
Sbjct: 653 VAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLE-------QEVSIL 705
Query: 986 KKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRG 1045
K + L AA+ G+ +S LL + +E+ F G T L A G
Sbjct: 706 CKDSRGRTPLHYAAARGHATWLSELLQMALSEED-------CCFKDNQGYTPLHWACYNG 758
Query: 1046 KLEVCRLLLEQGAA---VAQPNRRGAVPLFSTVRQGHWQIVDLLL--THGADVNMADKQG 1100
+LLEQ + P PL + H LLL + V+ D +G
Sbjct: 759 NENCIEVLLEQKCFRKFIGNP----FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKG 814
Query: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAA-T 1159
RTPL AA H+ + LL A + +D G TAL A G V LV++ A
Sbjct: 815 RTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADL 874
Query: 1160 DHADKNGRTPLDLAAFYGDAEVVQFLVD 1187
DK+ TPL LA G + ++D
Sbjct: 875 TVKDKDLNTPLHLACSKGHEKCALLILD 902
Score = 96.7 bits (239), Expect = 2e-19
Identities = 105/399 (26%), Positives = 172/399 (43%), Gaps = 60/399 (15%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
N++ +LL GA+ ++ + P+ ++ + + L+ GANV+ + + G T
Sbjct: 392 NVECIKLLQSSGADF-HKKDKCGRTPLHYAAANCHF-HCIETLVTTGANVNETDDWGRTA 449
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHL----------------------------DKNGQC 953
L YAAA+ +L + L DK G
Sbjct: 450 LHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYN 509
Query: 954 ALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLL-- 1011
++ +AA GH + ++ L++ T +G ++ S A + L AA G+ + + LL
Sbjct: 510 SIHYAAAYGHRQCLELLLER--TNSGFEES---DSGATKSPLHLAAYNGHHQALEVLLQS 564
Query: 1012 --DLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAV-AQPNRRGA 1068
DL +DE+ G TAL AA +G E L+ GA++ + N
Sbjct: 565 LVDLDIRDEK--------------GRTALDLAAFKGHTECVEALINPGASIFVKDNVTKR 610
Query: 1069 VPLFSTVRQGHWQIVDLLLTHGAD---VNMADKQGRTPLMMAASEGHLGTVDFLLAQGAS 1125
PL ++V GH + LLL + V++ D +G+TPLM+A + GH+ V LL + A+
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
Query: 1126 IALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1185
+ +D G TAL + GH V+ L++ + D GRTPL AA G A + L
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSEL 730
Query: 1186 VDHGAMIEHV---DYSGMRPLDRAVGCRNTSVVVTLLKK 1221
+ E D G PL A N + + LL++
Sbjct: 731 LQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769
Score = 94.7 bits (234), Expect = 8e-19
Identities = 100/391 (25%), Positives = 164/391 (41%), Gaps = 61/391 (15%)
Query: 889 LCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVV-LLCKKRAKVDHL 947
L + + G +V L+++GANV+ + +G TPL +AAA+ + ++ + LL A V+
Sbjct: 218 LHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQ 277
Query: 948 DKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIV 1007
K+G+ L A+ G + LIQ G+ V K + L AA G+ ++
Sbjct: 278 SKDGKSPLHMTAVHGRFTRSQTLIQ----NGGEIDCVDKDGNT---PLHVAARYGHELLI 330
Query: 1008 SYLLDLPEKDEE-------EVERAQINSFDSL----------------WGETALTAAAGR 1044
+ L + + A +N+ +G T L AAA
Sbjct: 331 NTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAG 390
Query: 1045 GKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPL 1104
G +E +LL GA + ++ G PL H+ ++ L+T GA+VN D GRT L
Sbjct: 391 GNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTAL 450
Query: 1105 MMAASEGH------LGT----------------------VDFLLAQGASIALMDKEGLTA 1136
AA+ LG ++FLL A+ ++ DKEG +
Sbjct: 451 HYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNS 510
Query: 1137 LSWACLKGHLSVVRSLVDNGAATDHADKNGRT--PLDLAAFYGDAEVVQFLVDHGAMIEH 1194
+ +A GH + L++ + +G T PL LAA+ G + ++ L+ ++
Sbjct: 511 IHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDI 570
Query: 1195 VDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1225
D G LD A +T V L+ GA I
Sbjct: 571 RDEKGRTALDLAAFKGHTECVEALINPGASI 601
Score = 59.7 bits (143), Expect = 3e-08
Identities = 46/169 (27%), Positives = 73/169 (43%), Gaps = 8/169 (4%)
Query: 1085 LLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKG 1144
+L+ DVN D + RTPL +AA G ++ L+ GA + D LT L A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 1145 HLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLD 1204
V+ L+ + A + DKN +TPL +AA + + ++ + + D G L
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 1205 RAVGCRNTSVVVTLLKKGAKIG--------PATWAMATSKPDIMIILLS 1245
A + +V LL KGA I WA D++ +L++
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 133 bits (335), Expect = 2e-30
Identities = 103/317 (32%), Positives = 143/317 (45%), Gaps = 31/317 (9%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G +V LL GA+V+ +G TPL A G+ +V LL ++ A V +D+ G+ AL
Sbjct: 52 GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
AA GH V + L+Q + A + H AA++G+T + + LL+ P
Sbjct: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHW-------AAALGHTLLAARLLEAPG 164
Query: 1016 KDEEEVERAQINSFDS----------------------LWGETALTAAAGRGKLEVCRLL 1053
E + + L G + AAAGRG R L
Sbjct: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGA--ALRFL 222
Query: 1054 LEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHL 1113
L +GA V + GA L G Q +++LL HGAD + D+ GR+ L AA+ GHL
Sbjct: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
Query: 1114 GTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLA 1173
V L+ QGA + D GLT L A +GH+ V L+D GA D +TPL LA
Sbjct: 283 LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
Query: 1174 AFYGDAEVVQFLVDHGA 1190
A G V L+ GA
Sbjct: 343 AERGHGPTVGLLLSRGA 359
Score = 92.4 bits (228), Expect = 4e-18
Identities = 75/237 (31%), Positives = 107/237 (45%), Gaps = 25/237 (10%)
Query: 1015 EKDEEEVERAQINSFDSL------------WGETALTAAAGRGKLEVCRLLLEQGAAVAQ 1062
E++E+E+ +++S ++L WG L A RG + LL QGA+V +
Sbjct: 12 EEEEQELRWMELDSEEALGTRTEGPSVVQGWGH--LLQAVWRGPAGLVTQLLRQGASVEE 69
Query: 1063 PNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQ 1122
+ G PL V +GH +V LLL GA V D+ GRT L AA GH + LL +
Sbjct: 70 RDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQR 129
Query: 1123 GASIALMDKEGLTALSWACLKGHLSVVRSLVD----NGAATDHADKNGRTPLDLAAFYGD 1178
GAS A GLT L WA GH + L++ AA + D G T AA G
Sbjct: 130 GASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGR 189
Query: 1179 AEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATS 1235
V++ L GA ++ L A + + LL +GA++ A AT+
Sbjct: 190 LAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLLARGARVDARDGAGATA 239
Score = 59.7 bits (143), Expect = 3e-08
Identities = 63/229 (27%), Positives = 88/229 (38%), Gaps = 59/229 (25%)
Query: 863 IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922
+ V LL GGA ++ L V + G + LL GA VDA +G T L
Sbjct: 190 LAVLELLAAGGAGLD---------GALLVAAAAGRGAALRFLLARGARVDARDGAGATAL 240
Query: 923 GYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQ 982
G AAA G + +L A D++G+ AL AA RGHL V+ L+
Sbjct: 241 GLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLV----------- 289
Query: 983 GVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAA 1042
+ A++++ D+L G T L A+
Sbjct: 290 --------------------------------------TQGAEVDARDTL-GLTPLHHAS 310
Query: 1043 GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 1091
G +EV LL++GA V PL +GH V LLL+ GA
Sbjct: 311 REGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 124 bits (310), Expect = 1e-27
Identities = 115/383 (30%), Positives = 172/383 (44%), Gaps = 38/383 (9%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
N KV LL+ A++N R ++ L V + T+ L ++++ + SG +
Sbjct: 86 NEKVLGLLLAHSADVNARDKLWQTP--LHVAAANRATKCAEALAPLLSSLNVADRSGRSA 143
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
L +A +G+L V LL K A ++ DK + L AA GHLEV+K L+ + +
Sbjct: 144 LHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKD 203
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
+ + H AA+ G E+V YLL + + +E N+F G TAL A
Sbjct: 204 RKGYGLLHT-------AAASGQIEVVKYLLRMGAEIDEP------NAF----GNTALHIA 246
Query: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLF-STVRQGHWQIVDLLLTHGADVNMADKQG 1100
G+ V L+ GA V QPN +G PL + V ++LL+ +GADVN K+G
Sbjct: 247 CYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEG 306
Query: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1160
++PL MAA G L+ G+ I DK G T L A GH ++ +L+ NGA T
Sbjct: 307 KSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTA 366
Query: 1161 HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMI--------EHV----------DYSGMRP 1202
+ PL LA +G ++ + L+ G + EHV D G
Sbjct: 367 RRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTC 426
Query: 1203 LDRAVGCRNTSVVVTLLKKGAKI 1225
L A N + LL GA +
Sbjct: 427 LHAAASGGNVECLNLLLSSGADL 449
Score = 116 bits (291), Expect = 2e-25
Identities = 113/388 (29%), Positives = 167/388 (43%), Gaps = 61/388 (15%)
Query: 858 LYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSES 917
+++ +++ R L+ NIN + L +++G ++ LLL GANV+A
Sbjct: 16 IFSRDVEEVRSLLSQKENINVLDQERRTP--LHAAAYVGDVPILQLLLMSGANVNAKDTL 73
Query: 918 GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDK---------------------------- 949
LTPL AAA+ ++ LL A V+ DK
Sbjct: 74 WLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSL 133
Query: 950 -----NGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYT 1004
+G+ AL HA GHLE V L+ G V K +Q L AA +G+
Sbjct: 134 NVADRSGRSALHHAVHSGHLETVNLLLN-----KGASLNVCDKKE--RQPLHWAAFLGHL 186
Query: 1005 EIVSYLL----DLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAV 1060
E++ L+ DL KD + G L AA G++EV + LL GA +
Sbjct: 187 EVLKLLVARGADLGCKDRK--------------GYGLLHTAAASGQIEVVKYLLRMGAEI 232
Query: 1061 AQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAA-SEGHLGTVDFL 1119
+PN G L G + L+ GA+VN + +G TPL +AA S ++ L
Sbjct: 233 DEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELL 292
Query: 1120 LAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDA 1179
+ GA + KEG + L A + G + + L+ NG+ D ADK G TPL +AA YG
Sbjct: 293 VNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHE 352
Query: 1180 EVVQFLVDHGAMIEHVDYSGMRPLDRAV 1207
++ L+ +GA M PL AV
Sbjct: 353 LLISTLMTNGADTARRGIHDMFPLHLAV 380
Score = 106 bits (265), Expect = 2e-22
Identities = 105/386 (27%), Positives = 157/386 (40%), Gaps = 45/386 (11%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G E + LLL GA++ + G TPL YAAA G V L A V+ D G L
Sbjct: 434 GNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPL 493
Query: 956 VHAALRGHLEVV---------------------KFLIQCDWTMAGQQQGVFKKSHAIQQA 994
+AA K C + + A
Sbjct: 494 HYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTA 553
Query: 995 LIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLL 1054
+ AA+ G + + LL++ E+VE S + L AA G E + L
Sbjct: 554 VHYAAAYGNRQNLELLLEMSFNCLEDVE--------STIPVSPLHLAAYNGHCEALKTLA 605
Query: 1055 EQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHL 1113
E + + +G LF +G + V++L HGA + +++ + TPL AA+ GH
Sbjct: 606 ETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHT 665
Query: 1114 GTVDFLLAQG--ASIA-LMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPL 1170
++ L+ G A I +MD G T L A + GH+ V L++ G+ D AD GRT L
Sbjct: 666 DSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725
Query: 1171 DLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKG-------- 1222
A G + + L+DH A + D+ G P+ A C +T+V+ TLL+
Sbjct: 726 HRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDA 785
Query: 1223 ----AKIGPATWAMATSKPDIMIILL 1244
+ P WA T D + +LL
Sbjct: 786 GVDYSGYSPMHWASYTGHEDCLELLL 811
Score = 102 bits (253), Expect = 5e-21
Identities = 86/299 (28%), Positives = 135/299 (45%), Gaps = 17/299 (5%)
Query: 921 PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980
PL A + + V L ++ ++ LD+ + L AA G + +++ L+ M+G
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLL-----MSGA 65
Query: 981 QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTA 1040
V K L AA+ +++ LL A +N+ D LW +T L
Sbjct: 66 N--VNAKDTLWLTPLHRAAASRNEKVLGLLL---------AHSADVNARDKLW-QTPLHV 113
Query: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100
AA + L +++ +R G L V GH + V+LLL GA +N+ DK+
Sbjct: 114 AAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKE 173
Query: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1160
R PL AA GHL + L+A+GA + D++G L A G + VV+ L+ GA D
Sbjct: 174 RQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEID 233
Query: 1161 HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219
+ G T L +A + G V LV+ GA + + G PL A N ++ + LL
Sbjct: 234 EPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELL 292
Score = 101 bits (251), Expect = 8e-21
Identities = 76/215 (35%), Positives = 105/215 (48%), Gaps = 6/215 (2%)
Query: 1016 KDEEEV-----ERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVP 1070
+D EEV ++ IN D T L AAA G + + +LLL GA V + P
Sbjct: 19 RDVEEVRSLLSQKENINVLDQE-RRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTP 77
Query: 1071 LFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMD 1130
L + +++ LLL H ADVN DK +TPL +AA+ + L +S+ + D
Sbjct: 78 LHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD 137
Query: 1131 KEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGA 1190
+ G +AL A GHL V L++ GA+ + DK R PL AAF G EV++ LV GA
Sbjct: 138 RSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGA 197
Query: 1191 MIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1225
+ D G L A VV LL+ GA+I
Sbjct: 198 DLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEI 232
Score = 100 bits (249), Expect = 1e-20
Identities = 98/367 (26%), Positives = 147/367 (40%), Gaps = 53/367 (14%)
Query: 896 GYTEMVALLLEFGANV--DASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQC 953
G + + LLLE N D S ++PL AA G+ + L + +D D G+
Sbjct: 561 GNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRT 620
Query: 954 ALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDL 1013
AL A RG E V+ L A + K+ L AAA+ G+T+ + L+D
Sbjct: 621 ALFLATERGSTECVEVLT------AHGASALIKERKRKWTPLHAAAASGHTDSLHLLID- 673
Query: 1014 PEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFS 1073
ERA I +G+T L A G ++ LLLE+G+ + RG L
Sbjct: 674 ------SGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHR 727
Query: 1074 TVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASI----ALM 1129
G + LL H A V D +GRTP+ +A++ GH + LL S A +
Sbjct: 728 GAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGV 787
Query: 1130 DKEGLTALSWACLKGHLSVVRSLVDNGAAT------------------------------ 1159
D G + + WA GH + L+++ +
Sbjct: 788 DYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALG 847
Query: 1160 ----DHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVV 1215
+ D GRTPL AAF + ++ L+ H A + D++G L A T+ V
Sbjct: 848 AKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAV 907
Query: 1216 VTLLKKG 1222
LL +G
Sbjct: 908 EFLLYRG 914
Score = 99.8 bits (247), Expect = 2e-20
Identities = 84/274 (30%), Positives = 125/274 (45%), Gaps = 17/274 (6%)
Query: 952 QCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLL 1011
Q LV A +E V+ L+ Q++ + + L AAA +G I+ LL
Sbjct: 9 QPPLVQAIFSRDVEEVRSLLS-------QKENINVLDQERRTPLHAAAYVGDVPILQLLL 61
Query: 1012 DLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPL 1071
+ A +N+ D+LW AAA R + +V LLL A V ++ PL
Sbjct: 62 ---------MSGANVNAKDTLWLTPLHRAAASRNE-KVLGLLLAHSADVNARDKLWQTPL 111
Query: 1072 FSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDK 1131
+ + L + +N+AD+ GR+ L A GHL TV+ LL +GAS+ + DK
Sbjct: 112 HVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDK 171
Query: 1132 EGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAM 1191
+ L WA GHL V++ LV GA D+ G L AA G EVV++L+ GA
Sbjct: 172 KERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAE 231
Query: 1192 IEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1225
I+ + G L A +V + L+ GA +
Sbjct: 232 IDEPNAFGNTALHIACYLGQDAVAIELVNAGANV 265
Score = 98.6 bits (244), Expect = 5e-20
Identities = 93/356 (26%), Positives = 149/356 (41%), Gaps = 51/356 (14%)
Query: 894 HLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQC 953
H G+ E V LLL GA+++ + PL +AA G+L ++ LL + A + D+ G
Sbjct: 149 HSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYG 208
Query: 954 ALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDL 1013
L AA G +EVVK+L++ + + F + AL A +G + L++
Sbjct: 209 LLHTAAASGQIEVVKYLLRMGAEI--DEPNAFGNT-----ALHIACYLGQDAVAIELVNA 261
Query: 1014 PEKDEEEVER-------------------------AQINSFDSLWGETALTAAAGRGKLE 1048
+ ++ A +N + S G++ L AA G+
Sbjct: 262 GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVN-YQSKEGKSPLHMAAIHGRFT 320
Query: 1049 VCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAA 1108
++L++ G+ + ++ G PL R GH ++ L+T+GAD PL +A
Sbjct: 321 RSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAV 380
Query: 1109 ------------SEGHLGTV------DFLLAQGASIALMDKEGLTALSWACLKGHLSVVR 1150
S G L ++ + +L+ G I D G T L A G++ +
Sbjct: 381 LFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLN 440
Query: 1151 SLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1206
L+ +GA DK GRTPL AA G + LV GA + D G PL A
Sbjct: 441 LLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYA 496
Score = 96.3 bits (238), Expect = 3e-19
Identities = 119/469 (25%), Positives = 187/469 (39%), Gaps = 82/469 (17%)
Query: 869 LILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAA 928
L+ GAN+N + P+ + LL+ GA+V+ S+ G +PL AA
Sbjct: 258 LVNAGANVNQPNDK-GFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIH 316
Query: 929 GYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKS 988
G + +L + +++D DK G L AA GH ++ L+ A ++G+
Sbjct: 317 GRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTA--RRGIHDMF 374
Query: 989 HAIQQALIAAASMGYTEIVSYLLD-------LPEKDEEEVERA--QINSFDSLWGETALT 1039
L A G+++ LL + E V A IN+ D+L G T L
Sbjct: 375 -----PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNL-GRTCLH 428
Query: 1040 AAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQ 1099
AAA G +E LLL GA + + ++ G PL G +Q L+T GA VN AD +
Sbjct: 429 AAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCK 488
Query: 1100 GRTPLMMAA-------SEGHLGT---------------------VDFLLAQGASIALMDK 1131
G +PL AA +E H + ++FLL GA +L D+
Sbjct: 489 GCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDR 548
Query: 1132 EGLTALSWA------------------CLK-----------------GHLSVVRSLVDNG 1156
+G TA+ +A CL+ GH +++L +
Sbjct: 549 QGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETL 608
Query: 1157 AATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGA-MIEHVDYSGMRPLDRAVGCRNTSVV 1215
D D GRT L LA G E V+ L HGA + PL A +T +
Sbjct: 609 VNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSL 668
Query: 1216 VTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAA 1264
L+ G + A + +M+ +++ ++ + +KG +AA
Sbjct: 669 HLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAA 717
Score = 94.0 bits (232), Expect = 1e-18
Identities = 97/318 (30%), Positives = 140/318 (44%), Gaps = 30/318 (9%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G+ + V LLLE G+ DA+ G T L A G + L A V D G+ +
Sbjct: 699 GHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPI 758
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
A+ GH V++ L+Q + GV ++ + A+ G+ + + LL+
Sbjct: 759 HLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYS---PMHWASYTGHEDCLELLLEH-- 813
Query: 1016 KDEEEVERAQINSFDSLWGE--TALTAAAGRGKLEVCRLLLEQGAA--VAQPNRRGAVPL 1071
+ F L G T L A + +LL A V + +G PL
Sbjct: 814 -----------SPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPL 862
Query: 1072 FSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQG-ASIALMD 1130
+ + + +LL H A+VN D GRT LM AA G V+FLL +G A + ++D
Sbjct: 863 HAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLD 922
Query: 1131 KEGLTALSWACLKGH----LSVVRSLVDNGA--ATDHADKNGRTPLDLAAFYGDAEVVQF 1184
+ TAL AC KGH L ++ D G AT+ A + PL +AA G A VVQ
Sbjct: 923 ENKNTALHLACSKGHEKCALMILAETQDLGLINATNSA---LQMPLHIAARNGLASVVQA 979
Query: 1185 LVDHGAMIEHVDYSGMRP 1202
L+ HGA + VD G P
Sbjct: 980 LLSHGATVLAVDEEGHTP 997
Score = 51.2 bits (121), Expect = 1e-05
Identities = 64/227 (28%), Positives = 92/227 (40%), Gaps = 34/227 (14%)
Query: 893 SHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIV-VLLCKKRAK-VDHLDKN 950
S+ G+ + + LLLE + TPL A S +LL AK V+ D
Sbjct: 799 SYTGHEDCLELLLEHSP-FSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAK 857
Query: 951 GQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYL 1010
G+ L AA ++ ++ L+Q Q V H + AL+ AA G T V +L
Sbjct: 858 GRTPLHAAAFADNVSGLRMLLQ-------HQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
Query: 1011 L-----DLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLL----EQGAAVA 1061
L DL DE + TAL A +G E C L++ + +
Sbjct: 911 LYRGKADLTVLDENK--------------NTALHLACSKGH-EKCALMILAETQDLGLIN 955
Query: 1062 QPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAA 1108
N +PL R G +V LL+HGA V D++G TP + A
Sbjct: 956 ATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 123 bits (309), Expect = 2e-27
Identities = 110/389 (28%), Positives = 164/389 (42%), Gaps = 64/389 (16%)
Query: 899 EMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHA 958
++ LLL GAN++ ++ LTPL A+ + +V ++ K AKV+ LD GQ +L A
Sbjct: 381 QICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440
Query: 959 ALRGHLEVVKFLIQ--CDWTMAGQQ--QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLP 1014
A GHL+ + L+ CD + Q + + +QQ L S+G +E LL+
Sbjct: 441 AYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAA 500
Query: 1015 EKDEEEVERA-----QINSFDSLWGE-TALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGA 1068
+ + E + +N D + T L AAG ++ V LL+ GA V ++ G
Sbjct: 501 KAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGL 560
Query: 1069 VPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL 1128
VPL + GH+++ +LL+ HGA VN+AD TPL AA++G LL GA
Sbjct: 561 VPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTK 620
Query: 1129 MDKEGLT--------------------ALSWACLKG------------------------ 1144
+++G T AL A KG
Sbjct: 621 KNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS 680
Query: 1145 ----------HLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEH 1194
+L V L+ +GA + DK G PL AA YG +V L+ + A +
Sbjct: 681 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA 740
Query: 1195 VDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
D PL A T + LL GA
Sbjct: 741 TDKWAFTPLHEAAQKGRTQLCALLLAHGA 769
Score = 103 bits (258), Expect = 1e-21
Identities = 115/428 (26%), Positives = 173/428 (40%), Gaps = 60/428 (14%)
Query: 868 LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAA 927
+ +L N+N + L + + ++V LLL+ GA+V A + L PL A +
Sbjct: 194 MALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACS 253
Query: 928 AGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQ--CDWTMAGQQQGVF 985
G+ + LL K A V+ +D L AA + +EV L+ D T+
Sbjct: 254 YGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN--- 310
Query: 986 KKSHAIQQALIAAASMGYTEIVSYLLD----LPEKDEEEVERAQ-------INSFDSLWG 1034
+ A+ A + E ++Y L E +V R + +N
Sbjct: 311 ------KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTH 364
Query: 1035 ETALTAAAGRG---KLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 1091
ETAL AA + ++C LLL +GA + + + PL + H +V++++ H A
Sbjct: 365 ETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA 424
Query: 1092 DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWA----------- 1140
VN D G+T L AA GHL T LL+ G ++ +G TAL
Sbjct: 425 KVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEG 484
Query: 1141 CLKGHLSVVRSLVDNGAATDHA--------------DKNGR--TPLDLAAFYGDAEVVQF 1184
G+ R L++ A D D GR TPL AA Y VV++
Sbjct: 485 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544
Query: 1185 LVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA--------KIGPATWAMATSK 1236
L+ HGA + D G+ PL A + V L+K GA K P A A K
Sbjct: 545 LLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGK 604
Query: 1237 PDIMIILL 1244
+I +LL
Sbjct: 605 YEICKLLL 612
Score = 94.0 bits (232), Expect = 1e-18
Identities = 81/263 (30%), Positives = 118/263 (44%), Gaps = 34/263 (12%)
Query: 1017 DEEEVERA----QINSFDSLWGE-TALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPL 1071
D E V+R ++NS D+ + T L AAG G+ +V LL+ GA V + G +PL
Sbjct: 36 DVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPL 95
Query: 1072 FSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDK 1131
+ GH ++V+LLL HGAD N D TPL AA +G + LL GA + +
Sbjct: 96 HNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNT 155
Query: 1132 EGLTALSWA--------------------CLKGHLSVVRSLVDNGAATDHA-DKNGRTPL 1170
+G TAL A G+ + +L+ HA D TPL
Sbjct: 156 DGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPL 215
Query: 1171 DLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIG---- 1226
LAA Y ++VQ L+ HGA + D + PL A + V L+K GA +
Sbjct: 216 HLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDL 275
Query: 1227 ----PATWAMATSKPDIMIILLS 1245
P A + ++ ++ +LLS
Sbjct: 276 WQFTPLHEAASKNRVEVCSLLLS 298
Score = 88.2 bits (217), Expect = 7e-17
Identities = 80/251 (31%), Positives = 107/251 (42%), Gaps = 22/251 (8%)
Query: 900 MVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAA 959
+V LL+ GA+V A + GL PL A + G+ + LL K A V+ D L AA
Sbjct: 541 VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA 600
Query: 960 LRGHLEVVKFLIQ--CDWTMAGQQQG-----VFKKSHAIQQ------ALIAAASMGYTEI 1006
+G E+ K L+Q D T + V IQ AL+ AA G
Sbjct: 601 AKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLAR 660
Query: 1007 VSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRR 1066
V L + + + T L AAG LEV LL+ GA V ++
Sbjct: 661 VKKLSSPDNVNCRDTQGRH---------STPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711
Query: 1067 GAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASI 1126
G +PL + GH + LL+ + A VN DK TPL AA +G LLA GA
Sbjct: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771
Query: 1127 ALMDKEGLTAL 1137
L ++EG T L
Sbjct: 772 TLKNQEGQTPL 782
Score = 86.7 bits (213), Expect = 2e-16
Identities = 102/419 (24%), Positives = 161/419 (38%), Gaps = 96/419 (22%)
Query: 865 VSRLLILGGANINYRTE----VLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLT 920
V L+ GAN+ R + L+NA G+ E+V LLL GA+ +A T
Sbjct: 73 VVEYLLQNGANVQARDDGGLIPLHNA------CSFGHAEVVNLLLRHGADPNARDNWNYT 126
Query: 921 PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980
PL AA G + + ++L + A+ + +G+ AL A D +
Sbjct: 127 PLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA---------------DPSAKAV 171
Query: 981 QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTA 1040
G +KK ++ +A S ++++ L L R T L
Sbjct: 172 LTGEYKKDELLE----SARSGNEEKMMALLTPLNVNCHASDGRK----------STPLHL 217
Query: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100
AAG ++++ +LLL+ GA V ++ VPL + GH+++ +LL+ HGA VN D
Sbjct: 218 AAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQ 277
Query: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWA-------------------- 1140
TPL AAS+ + LL+ GA L++ +A+ A
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
Query: 1141 --------CLKGHLS-----------------------------VVRSLVDNGAATDHAD 1163
+K HLS + L+ GA +
Sbjct: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKT 397
Query: 1164 KNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKG 1222
K TPL +A+ +VV+ +V H A + +D G L RA C + LL G
Sbjct: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYG 456
Score = 80.1 bits (196), Expect = 2e-14
Identities = 83/272 (30%), Positives = 118/272 (43%), Gaps = 42/272 (15%)
Query: 943 KVDHLDKNGQCA--LVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAAS 1000
KV+ D G+ + L AA G +VV++L+Q + + G H A S
Sbjct: 48 KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHN-------ACS 100
Query: 1001 MGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAA- 1059
G+ E+V+ LL A N+ D+ W T L AA +GK++VC +LL+ GA
Sbjct: 101 FGHAEVVNLLLR---------HGADPNARDN-WNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
Query: 1060 ------------VAQPNRRGAVP-------LFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100
+A P+ + + L + R G+ + + LLT +VN G
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDG 209
Query: 1101 R--TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAA 1158
R TPL +AA + V LL GA + DK L L AC GH V LV +GA
Sbjct: 210 RKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGAC 269
Query: 1159 TDHADKNGRTPLDLAAFYGDAEVVQFLVDHGA 1190
+ D TPL AA EV L+ +GA
Sbjct: 270 VNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 120 bits (300), Expect = 2e-26
Identities = 93/304 (30%), Positives = 148/304 (48%), Gaps = 26/304 (8%)
Query: 895 LGYTEMVALLLEFGANVDASSES-GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQC 953
LG+ ++V LLLE + S+S G TPL YAA + + V + K + D D G+
Sbjct: 265 LGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRT 324
Query: 954 ALVHAALRGHLEVVKFLIQC----DWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSY 1009
+ + AA +G +V++ ++ D MA + G AL AAA G+ V
Sbjct: 325 SFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGT---------ALHAAALSGHVSTVKL 375
Query: 1010 LLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAV 1069
LL+ AQ+++ D + T L A G +V + L++ GA V ++ G
Sbjct: 376 LLE---------NNAQVDATDVM-KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425
Query: 1070 PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALM 1129
L G+ + +L+ + + N+ D GRTPL AA G++ + L+ A +
Sbjct: 426 LLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQ 485
Query: 1130 DKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGR--TPLDLAAFYGDAEVVQFLVD 1187
DKEG TAL W+C G+L ++ L+D A + + N TPLD A EV+QF+++
Sbjct: 486 DKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
Query: 1188 HGAM 1191
HGA+
Sbjct: 546 HGAL 549
Score = 102 bits (253), Expect = 5e-21
Identities = 88/308 (28%), Positives = 129/308 (41%), Gaps = 50/308 (16%)
Query: 918 GLTPLGYAAAAGYLSIV-VLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWT 976
G TPL +A A G +++V VL + + D + L AAL GH ++V L++ +
Sbjct: 221 GRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERN-- 278
Query: 977 MAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE-KDEEEVERAQINSFDSLWGE 1035
+ G L AA + E V L P KD+ ++E G
Sbjct: 279 ----KSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLE-----------GR 323
Query: 1036 TALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNM 1095
T+ AAG+G +V R +L L D+NM
Sbjct: 324 TSFMWAAGKGSDDVLRTMLS-------------------------------LKSDIDINM 352
Query: 1096 ADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDN 1155
ADK G T L AA GH+ TV LL A + D T L AC GH V+++L+
Sbjct: 353 ADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1156 GAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVV 1215
GA D D++G + L AA G+A+V Q L+++ DY+G PL A + +
Sbjct: 413 GARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCM 472
Query: 1216 VTLLKKGA 1223
L++ A
Sbjct: 473 AVLMENNA 480
Score = 88.6 bits (218), Expect = 6e-17
Identities = 108/395 (27%), Positives = 155/395 (39%), Gaps = 37/395 (9%)
Query: 869 LILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAA 928
L+ GA++N A L Q G + LLL AN +TPL
Sbjct: 67 LLKAGADVNKTDHSQRTALHLAAQK--GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRH 124
Query: 929 GYLSIVVLLCKKRA--KVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMA-----GQQ 981
+ LL K A +VD DKN Q AL +A + E VK LI+ D + G+
Sbjct: 125 RSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI 184
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
+ +H A+ V +LD + + ++ G T L A
Sbjct: 185 PLHWAANHKDPSAV---------HTVRCILDAAPTES-------LLNWQDYEGRTPLHFA 228
Query: 1042 AGRGKLEVCRLLLE-QGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNM-ADKQ 1099
G + V +L + + + PL GH QIV LLL + +D Q
Sbjct: 229 VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ 288
Query: 1100 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1159
G TPL AA TV L + D EG T+ WA KG V+R+++ +
Sbjct: 289 GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
Query: 1160 D--HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVT 1217
D ADK G T L AA G V+ L+++ A ++ D PL RA + V+ T
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408
Query: 1218 LLKKGAKIGPAT--------WAMATSKPDIMIILL 1244
L+K GA++ WA D+ IL+
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 443
Score = 66.2 bits (160), Expect = 3e-10
Identities = 55/181 (30%), Positives = 80/181 (44%), Gaps = 2/181 (1%)
Query: 1040 AAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQ 1099
AA K + RL++ A + ++ G PL V D LL GADVN D
Sbjct: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
Query: 1100 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGA-- 1157
RT L +AA +G+ + LL + A+ D E +T L + L+ A
Sbjct: 81 QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140
Query: 1158 ATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVT 1217
D DKN +T L +A+Y + E V+ L+ H + I D G PL A ++ S V T
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200
Query: 1218 L 1218
+
Sbjct: 201 V 201
Score = 56.2 bits (134), Expect = 3e-07
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 8/206 (3%)
Query: 1021 VERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW 1080
V + + + +G T L +L+ LL+ GA V + + L ++G++
Sbjct: 35 VGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNY 94
Query: 1081 QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGA--SIALMDKEGLTALS 1138
+ + LLLT A+ D + TPL + + LL A + DK TAL
Sbjct: 95 RFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALH 154
Query: 1139 WACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGD---AEVVQFLVDHG---AMI 1192
W+ + V+ L+ + + D G+ PL AA + D V+ ++D +++
Sbjct: 155 WSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLL 214
Query: 1193 EHVDYSGMRPLDRAVGCRNTSVVVTL 1218
DY G PL AV N +VV L
Sbjct: 215 NWQDYEGRTPLHFAVADGNVTVVDVL 240
Score = 45.1 bits (105), Expect = 7e-04
Identities = 30/107 (28%), Positives = 55/107 (51%), Gaps = 2/107 (1%)
Query: 865 VSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGY 924
V + LI GGA ++ + + +L + G ++ +L+E N + +G TPL
Sbjct: 405 VIQTLIKGGARVDLVDQ--DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQC 462
Query: 925 AAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLI 971
AA GY++ + +L + A + DK G+ AL + G+L+ +K L+
Sbjct: 463 AAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 40.4 bits (93), Expect = 0.017
Identities = 36/117 (30%), Positives = 50/117 (42%), Gaps = 5/117 (4%)
Query: 1107 AASEGHLGTVDFLLAQGASIALMDKE---GLTALSWACLKGHLSVVRSLVDNGAATDHAD 1163
AA G G + L+ + AL DKE G T L + L L +L+ GA + D
Sbjct: 21 AAVNGDKGALQRLIVGNS--ALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTD 78
Query: 1164 KNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLK 1220
+ RT L LAA G+ ++ L+ A D M PL R+ + LLK
Sbjct: 79 HSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
Score = 40.0 bits (92), Expect = 0.023
Identities = 30/113 (26%), Positives = 56/113 (49%), Gaps = 4/113 (3%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
N V ++LI N N + + P+ C ++ GY +A+L+E A+ + + G T
Sbjct: 435 NADVCQILIENKINPNVQ-DYAGRTPLQCA-AYGGYINCMAVLMENNADPNIQDKEGRTA 492
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQ--CALVHAALRGHLEVVKFLIQ 972
L ++ GYL + LL A + ++ N + L +A L EV++F+++
Sbjct: 493 LHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 120 bits (300), Expect = 2e-26
Identities = 93/304 (30%), Positives = 148/304 (48%), Gaps = 26/304 (8%)
Query: 895 LGYTEMVALLLEFGANVDASSES-GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQC 953
LG+ ++V LLLE + S+S G TPL YAA + + V + K + D D G+
Sbjct: 265 LGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRT 324
Query: 954 ALVHAALRGHLEVVKFLIQC----DWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSY 1009
+ + AA +G +V++ ++ D MA + G AL AAA G+ V
Sbjct: 325 SFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGT---------ALHAAALSGHVSTVKL 375
Query: 1010 LLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAV 1069
LL+ AQ+++ D + T L A G +V + L++ GA V ++ G
Sbjct: 376 LLE---------NNAQVDATDVM-KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425
Query: 1070 PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALM 1129
L G+ + +L+ + + N+ D GRTPL AA G++ + L+ A +
Sbjct: 426 LLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQ 485
Query: 1130 DKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGR--TPLDLAAFYGDAEVVQFLVD 1187
DKEG TAL W+C G+L ++ L+D A + + N TPLD A EV+QF+++
Sbjct: 486 DKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
Query: 1188 HGAM 1191
HGA+
Sbjct: 546 HGAL 549
Score = 102 bits (253), Expect = 5e-21
Identities = 88/308 (28%), Positives = 129/308 (41%), Gaps = 50/308 (16%)
Query: 918 GLTPLGYAAAAGYLSIV-VLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWT 976
G TPL +A A G +++V VL + + D + L AAL GH ++V L++ +
Sbjct: 221 GRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERN-- 278
Query: 977 MAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE-KDEEEVERAQINSFDSLWGE 1035
+ G L AA + E V L P KD+ ++E G
Sbjct: 279 ----KSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLE-----------GR 323
Query: 1036 TALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNM 1095
T+ AAG+G +V R +L L D+NM
Sbjct: 324 TSFMWAAGKGSDDVLRTMLS-------------------------------LKSDIDINM 352
Query: 1096 ADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDN 1155
ADK G T L AA GH+ TV LL A + D T L AC GH V+++L+
Sbjct: 353 ADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1156 GAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVV 1215
GA D D++G + L AA G+A+V Q L+++ DY+G PL A + +
Sbjct: 413 GARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCM 472
Query: 1216 VTLLKKGA 1223
L++ A
Sbjct: 473 AVLMENNA 480
Score = 88.6 bits (218), Expect = 6e-17
Identities = 108/395 (27%), Positives = 155/395 (39%), Gaps = 37/395 (9%)
Query: 869 LILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAA 928
L+ GA++N A L Q G + LLL AN +TPL
Sbjct: 67 LLKAGADVNKTDHSQRTALHLAAQK--GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRH 124
Query: 929 GYLSIVVLLCKKRA--KVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMA-----GQQ 981
+ LL K A +VD DKN Q AL +A + E VK LI+ D + G+
Sbjct: 125 RSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI 184
Query: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041
+ +H A+ V +LD + + ++ G T L A
Sbjct: 185 PLHWAANHKDPSAV---------HTVRCILDAAPTES-------LLNWQDYEGRTPLHFA 228
Query: 1042 AGRGKLEVCRLLLE-QGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNM-ADKQ 1099
G + V +L + + + PL GH QIV LLL + +D Q
Sbjct: 229 VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ 288
Query: 1100 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1159
G TPL AA TV L + D EG T+ WA KG V+R+++ +
Sbjct: 289 GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
Query: 1160 D--HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVT 1217
D ADK G T L AA G V+ L+++ A ++ D PL RA + V+ T
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408
Query: 1218 LLKKGAKIGPAT--------WAMATSKPDIMIILL 1244
L+K GA++ WA D+ IL+
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 443
Score = 66.2 bits (160), Expect = 3e-10
Identities = 55/181 (30%), Positives = 80/181 (44%), Gaps = 2/181 (1%)
Query: 1040 AAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQ 1099
AA K + RL++ A + ++ G PL V D LL GADVN D
Sbjct: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
Query: 1100 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGA-- 1157
RT L +AA +G+ + LL + A+ D E +T L + L+ A
Sbjct: 81 QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140
Query: 1158 ATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVT 1217
D DKN +T L +A+Y + E V+ L+ H + I D G PL A ++ S V T
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200
Query: 1218 L 1218
+
Sbjct: 201 V 201
Score = 56.2 bits (134), Expect = 3e-07
Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 8/206 (3%)
Query: 1021 VERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW 1080
V + + + +G T L +L+ LL+ GA V + + L ++G++
Sbjct: 35 VGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNY 94
Query: 1081 QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGA--SIALMDKEGLTALS 1138
+ + LLLT A+ D + TPL + + LL A + DK TAL
Sbjct: 95 RFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALH 154
Query: 1139 WACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGD---AEVVQFLVDHG---AMI 1192
W+ + V+ L+ + + D G+ PL AA + D V+ ++D +++
Sbjct: 155 WSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLL 214
Query: 1193 EHVDYSGMRPLDRAVGCRNTSVVVTL 1218
DY G PL AV N +VV L
Sbjct: 215 NWQDYEGRTPLHFAVADGNVTVVDVL 240
Score = 45.1 bits (105), Expect = 7e-04
Identities = 30/107 (28%), Positives = 55/107 (51%), Gaps = 2/107 (1%)
Query: 865 VSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGY 924
V + LI GGA ++ + + +L + G ++ +L+E N + +G TPL
Sbjct: 405 VIQTLIKGGARVDLVDQ--DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQC 462
Query: 925 AAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLI 971
AA GY++ + +L + A + DK G+ AL + G+L+ +K L+
Sbjct: 463 AAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 40.4 bits (93), Expect = 0.017
Identities = 36/117 (30%), Positives = 50/117 (42%), Gaps = 5/117 (4%)
Query: 1107 AASEGHLGTVDFLLAQGASIALMDKE---GLTALSWACLKGHLSVVRSLVDNGAATDHAD 1163
AA G G + L+ + AL DKE G T L + L L +L+ GA + D
Sbjct: 21 AAVNGDKGALQRLIVGNS--ALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTD 78
Query: 1164 KNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLK 1220
+ RT L LAA G+ ++ L+ A D M PL R+ + LLK
Sbjct: 79 HSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
Score = 40.0 bits (92), Expect = 0.023
Identities = 30/113 (26%), Positives = 56/113 (49%), Gaps = 4/113 (3%)
Query: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
N V ++LI N N + + P+ C ++ GY +A+L+E A+ + + G T
Sbjct: 435 NADVCQILIENKINPNVQ-DYAGRTPLQCA-AYGGYINCMAVLMENNADPNIQDKEGRTA 492
Query: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQ--CALVHAALRGHLEVVKFLIQ 972
L ++ GYL + LL A + ++ N + L +A L EV++F+++
Sbjct: 493 LHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 117 bits (294), Expect = 9e-26
Identities = 107/370 (28%), Positives = 162/370 (43%), Gaps = 23/370 (6%)
Query: 868 LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAA 927
LL+ GA+ N R + AP+ + G LLL+ GA VDA G TPL AA
Sbjct: 413 LLLAHGADAN-RVDEDGWAPLHFAAQN-GDDGTARLLLDHGACVDAQEREGWTPLHLAAQ 470
Query: 928 AGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKK 987
+ ++ LL ++A + + G+ L AA GH+ +VK L + QQ+ +
Sbjct: 471 NNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP 530
Query: 988 SHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKL 1047
H A G + +LL A ++ D G L AA RGK
Sbjct: 531 LHL-------AVERGKVRAIQHLLK---------SGAVPDALDQS-GYGPLHTAAARGKY 573
Query: 1048 EVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMA 1107
+C++LL GA++ P +G PL +GH +I+ LL A++ TPL +A
Sbjct: 574 LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
Query: 1108 ASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGR 1167
A G V LL GA ++ G T L A + V +L+++ A +K G
Sbjct: 634 ARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGW 693
Query: 1168 TPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGP 1227
TP LAA G+ +++ LV+ GA ++ D PL A+ R ++ L K P
Sbjct: 694 TPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGK----EP 749
Query: 1228 ATWAMATSKP 1237
+ + SKP
Sbjct: 750 SVATLGGSKP 759
Score = 110 bits (274), Expect = 2e-23
Identities = 99/330 (30%), Positives = 139/330 (42%), Gaps = 17/330 (5%)
Query: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
G E V LLL +VD + SG TPL AA + LL A + +D++G L
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
Query: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
AA G + L+ + Q++ + H A+ E V+ LL
Sbjct: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHL--------AAQNNFENVARLL---- 480
Query: 1016 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTV 1075
V R + G+T L AA G + + +LL QGA + R PL V
Sbjct: 481 -----VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAV 535
Query: 1076 RQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLT 1135
+G + + LL GA + D+ G PL AA+ G LL GAS+ L +G T
Sbjct: 536 ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWT 595
Query: 1136 ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHV 1195
L A KGHL ++ L ++ A TPL LAA +G+ VV L+ GA
Sbjct: 596 PLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAA 655
Query: 1196 DYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1225
+ SG PL AV V+ LL+ A +
Sbjct: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANV 685
Score = 94.4 bits (233), Expect = 1e-18
Identities = 63/188 (33%), Positives = 84/188 (44%)
Query: 1036 TALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNM 1095
T L +G +E RLLL V G PL + + LLL HGAD N
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 1096 ADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDN 1155
D+ G PL AA G GT LL GA + ++EG T L A +V R LV
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
Query: 1156 GAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVV 1215
A + + G+TPL +AA++G +V+ L GA ++ + PL AV +
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
Query: 1216 VTLLKKGA 1223
LLK GA
Sbjct: 544 QHLLKSGA 551
Score = 78.2 bits (191), Expect = 8e-14
Identities = 54/156 (34%), Positives = 74/156 (47%)
Query: 1070 PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALM 1129
PL V QG + V LLL H DV+ G TPL++AA + LLA GA +
Sbjct: 365 PLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRV 424
Query: 1130 DKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHG 1189
D++G L +A G R L+D+GA D ++ G TPL LAA V + LV
Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQ 484
Query: 1190 AMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1225
A + G PL A + S+V L +GA++
Sbjct: 485 ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL 520
Score = 36.2 bits (82), Expect = 0.33
Identities = 27/90 (30%), Positives = 39/90 (43%)
Query: 1134 LTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1193
+T L + +G + VR L+ + D +G TPL +AA ++ L+ HGA
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 1194 HVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
VD G PL A + LL GA
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGA 452
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 115 bits (287), Expect = 6e-25
Identities = 110/368 (29%), Positives = 162/368 (44%), Gaps = 36/368 (9%)
Query: 884 NNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAK 943
+ A +L + G E LL AN + S+ G TPL A +V LL ++
Sbjct: 437 SGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKIS 496
Query: 944 VDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGY 1003
V+ D++ AL AA G + L++ + V + + + A G
Sbjct: 497 VNAKDEDQWTALHFAAQNGDESSTRLLLE-------KNASVNEVDFEGRTPMHVACQHGQ 549
Query: 1004 TEIVSYLLDLPEKDEEEVERAQINSFDSLWGETA---LTAAAGRGKLEVCRLLLEQ-GAA 1059
IV LL R ++ SL G+ A L AA +G L + +LL +Q G +
Sbjct: 550 ENIVRILL-----------RRGVDV--SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596
Query: 1060 VAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFL 1119
V G PL ++GH+++ +L+ +DVN+ +TPL +AA GH T L
Sbjct: 597 VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLL 656
Query: 1120 LAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDA 1179
L +GA M +G TAL A GHL+ V+ LV+ A +T L LAA +G +
Sbjct: 657 LHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716
Query: 1180 EVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI-----------GPA 1228
EVV+ LV +I+ D G+ L A R+ V TLL+ GA I GPA
Sbjct: 717 EVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGPA 775
Query: 1229 TWAMATSK 1236
+ SK
Sbjct: 776 ATLLRRSK 783
Score = 51.2 bits (121), Expect = 1e-05
Identities = 36/134 (26%), Positives = 61/134 (45%)
Query: 1092 DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRS 1151
DV++A G + L +A G +LL A+ L ++ G T L A + VV
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
Query: 1152 LVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRN 1211
L+ + + D++ T L AA GD + L++ A + VD+ G P+ A
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
Query: 1212 TSVVVTLLKKGAKI 1225
++V LL++G +
Sbjct: 550 ENIVRILLRRGVDV 563
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,859,931
Number of Sequences: 37866
Number of extensions: 4147869
Number of successful extensions: 36553
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 453
Number of HSP's successfully gapped in prelim test: 831
Number of HSP's that attempted gapping in prelim test: 23080
Number of HSP's gapped (non-prelim): 9605
length of query: 1990
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1873
effective length of database: 13,817,196
effective search space: 25879608108
effective search space used: 25879608108
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.