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Search of human proteins with 157502201
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157502201 ATP-binding cassette, sub-family C, member 4
isoform 1 [Homo sapiens]
(1325 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 2618 0.0
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 1670 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 848 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 830 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 795 0.0
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 758 0.0
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 755 0.0
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 736 0.0
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 733 0.0
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 703 0.0
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 703 0.0
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 686 0.0
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 675 0.0
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 674 0.0
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 665 0.0
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 661 0.0
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 654 0.0
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 654 0.0
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 643 0.0
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 640 0.0
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 494 e-139
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 414 e-115
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 236 1e-61
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 210 6e-54
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 206 9e-53
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 184 6e-46
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 152 2e-36
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 151 4e-36
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 148 4e-35
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 147 9e-35
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 2618 bits (6787), Expect = 0.0
Identities = 1325/1325 (100%), Positives = 1325/1325 (100%)
Query: 1 MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL 60
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL
Sbjct: 1 MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL 60
Query: 61 QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF 120
QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF
Sbjct: 61 QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF 120
Query: 121 ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR 180
ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
Sbjct: 121 ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR 180
Query: 181 LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG 240
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG
Sbjct: 181 LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG 240
Query: 241 MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT 300
MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT
Sbjct: 241 MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT 300
Query: 301 NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA 360
NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
Sbjct: 301 NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA 360
Query: 361 VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD 420
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD
Sbjct: 361 VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD 420
Query: 421 KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ 480
KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ
Sbjct: 421 KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ 480
Query: 481 QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK 540
QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
Sbjct: 481 QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK 540
Query: 541 ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA 600
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA
Sbjct: 541 ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA 600
Query: 601 SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW 660
SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW
Sbjct: 601 SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW 660
Query: 661 SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL 720
SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL
Sbjct: 661 SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL 720
Query: 721 NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI 780
NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI
Sbjct: 721 NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI 780
Query: 781 ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF 840
ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF
Sbjct: 781 ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF 840
Query: 841 LDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPV 900
LDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPV
Sbjct: 841 LDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPV 900
Query: 901 FSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFV 960
FSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFV
Sbjct: 901 FSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFV 960
Query: 961 IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLE 1020
IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLE
Sbjct: 961 IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLE 1020
Query: 1021 KEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAG 1080
KEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAG
Sbjct: 1021 KEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAG 1080
Query: 1081 KSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNE 1140
KSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNE
Sbjct: 1081 KSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNE 1140
Query: 1141 HTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILII 1200
HTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILII
Sbjct: 1141 HTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILII 1200
Query: 1201 DEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYV 1260
DEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYV
Sbjct: 1201 DEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYV 1260
Query: 1261 LLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTI 1320
LLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTI
Sbjct: 1261 LLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTI 1320
Query: 1321 FETAL 1325
FETAL
Sbjct: 1321 FETAL 1325
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 1670 bits (4326), Expect = 0.0
Identities = 845/845 (100%), Positives = 845/845 (100%)
Query: 1 MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL 60
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL
Sbjct: 1 MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL 60
Query: 61 QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF 120
QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF
Sbjct: 61 QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF 120
Query: 121 ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR 180
ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
Sbjct: 121 ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR 180
Query: 181 LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG 240
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG
Sbjct: 181 LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG 240
Query: 241 MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT 300
MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT
Sbjct: 241 MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT 300
Query: 301 NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA 360
NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
Sbjct: 301 NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA 360
Query: 361 VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD 420
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD
Sbjct: 361 VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD 420
Query: 421 KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ 480
KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ
Sbjct: 421 KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ 480
Query: 481 QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK 540
QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
Sbjct: 481 QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK 540
Query: 541 ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA 600
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA
Sbjct: 541 ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA 600
Query: 601 SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW 660
SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW
Sbjct: 601 SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW 660
Query: 661 SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL 720
SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL
Sbjct: 661 SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL 720
Query: 721 NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI 780
NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI
Sbjct: 721 NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI 780
Query: 781 ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF 840
ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF
Sbjct: 781 ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF 840
Query: 841 LDFIQ 845
LDFIQ
Sbjct: 841 LDFIQ 845
Score = 90.1 bits (222), Expect = 1e-17
Identities = 118/562 (20%), Positives = 236/562 (41%), Gaps = 57/562 (10%)
Query: 710 HWIVFIFLILLNTAAQVAYVLQDWWL----SYWANKQSMLNVTVNGGGNVTEKLDLNWYL 765
+W ++ L + + A V+Q +L +Y+ N M +V LN
Sbjct: 88 YWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVA------------LNTAY 135
Query: 766 GIYSGLTVATVLFGIARSLLVFYVLVNSSQ---TLHNKMFESILKAPVLFFDRNPIGRIL 822
+ LT T++ I L ++V + + + ++ L+ + + G+I+
Sbjct: 136 AYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIV 195
Query: 823 NRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLG-----IIFIF 877
N S D+ D + FL F L + ++AV + W+ I + L II +
Sbjct: 196 NLLSNDVNKFDQVT--VFLHF----LWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLP 249
Query: 878 LRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELF------DAHQ 931
L+ F + ++ +T ++ + G+ I+ Y E+ L + +
Sbjct: 250 LQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISK 309
Query: 932 DLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMG 991
L S + + +F+ + F V GS+I A + V L + LT+
Sbjct: 310 ILRSSC-LRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVA-VTLYGAVRLTVTL 367
Query: 992 MFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYS 1051
F + + +E ++S+ R+ + L++ + + R P+ + V + D F
Sbjct: 368 FFPSAIERVSEA---IVSIRRIQTFLLLDEISQ---RNRQLPSDGKKMVHVQDFTAFWDK 421
Query: 1052 PGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLH 1111
L+ L+ ++ E + +VG GAGKSSL+SA+ L E L GL
Sbjct: 422 ASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAV--LGE----------LAPSHGLV 469
Query: 1112 DLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELA 1171
+ +++ + Q+P +F+GT+R N+ ++ E ++ LK+ ++ L T +
Sbjct: 470 SVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIG 529
Query: 1172 ESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTD-ELIQKKIREKFAHCTVLT 1230
+ G+ S GQ+ V LARA+ + I ++D+ + VD L + I + +
Sbjct: 530 DRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITIL 589
Query: 1231 IAHRLNTIIDSDKIMVLDSGRL 1252
+ H+L + + +I++L G++
Sbjct: 590 VTHQLQYLKAASQILILKDGKM 611
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 848 bits (2192), Expect = 0.0
Identities = 506/1356 (37%), Positives = 773/1356 (57%), Gaps = 103/1356 (7%)
Query: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
L W KE + K PSL +
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
Query: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL-PMVISSIVQA 609
Query: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
Query: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
G L+AVVG VG GKSSLLSA+L E+ G V++ G +AYV QQ W+ + +LR NILF
Sbjct: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILF 728
Query: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
G + E+ Y VI+ACAL DL++L GD T IG++G LSGGQK RV+LARAVY +ADI
Sbjct: 729 GCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADI 788
Query: 556 YLLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
YL DDPLSAVDA V +H+FE I +L K ILVTH + YL I+++ GK+ +
Sbjct: 789 YLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISE 848
Query: 614 KGTYTEFLKSGIDFGSLLK--------KDNEESEQPPVPG----TPTLRN---------- 651
G+Y E L F L+ +D EE+ V G + N
Sbjct: 849 MGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK 908
Query: 652 ---RTFSESSVWSQQSSRPSLKDGALESQDTENVPV-TLSEENRSE-GKVGFQAYKNYFR 706
R S SS +S SR L+ + + L E ++++ G+V Y +Y +
Sbjct: 909 QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMK 968
Query: 707 AGAHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNW 763
A +I F IFL + N + +A ++WLS W + + VNG T+ +L +
Sbjct: 969 AIGLFISFLSIFLFMCNHVSALA---SNYWLSLWTD-----DPIVNGTQEHTKVRLSVYG 1020
Query: 764 YLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILN 823
LGI G+ V FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++N
Sbjct: 1021 ALGISQGIAV----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVN 1074
Query: 824 RFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFL 883
RFSK++ +D ++P F+ +L V+G V + P AI + PLG+I+ F++R+++
Sbjct: 1075 RFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYV 1134
Query: 884 ETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLT 943
+SR +KRLES +RSPV+SH + +L G+ IRA++ +ER D D + +A++ +
Sbjct: 1135 ASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIV 1194
Query: 944 TSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEV 1003
+RW AVRL+ + V+ A ++I +L AG VGL++SY+L + W VR S+E+
Sbjct: 1195 ANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEM 1254
Query: 1004 ENMMISVERVIEYTDLEKEAPWEYQKRPPPA-WPHEGVIIFDNVNFMYSPGGPLVLKHLT 1062
E +++VER+ EY++ EKEAPW+ Q+ PP+ WP G + F N Y VL+H+
Sbjct: 1255 ETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHIN 1314
Query: 1063 ALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIP 1121
I EKVGIVGRTGAGKSSL LFR++E EG+I ID I +IGLHDLR K++IIP
Sbjct: 1315 VTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIP 1374
Query: 1122 QEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQ 1181
Q+PVLF+G++R NLDPF++++DEE+W +L+ LK+ + LP K+D E AE G N SVGQ
Sbjct: 1375 QDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQ 1434
Query: 1182 RQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDS 1241
RQLVCLARA+LRK +IL++DEATA VD TD+LIQ IR +F CTVLTIAHRLNTI+D
Sbjct: 1435 RQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDY 1494
Query: 1242 DKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLG 1277
+++VLD G ++EY P LLQ + LFY M + G
Sbjct: 1495 TRVIVLDKGEIQEYGAPSDLLQQR-GLFYSMAKDAG 1529
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 830 bits (2145), Expect = 0.0
Identities = 490/1362 (35%), Positives = 765/1362 (56%), Gaps = 105/1362 (7%)
Query: 7 EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDK 66
E NP A+ S + + W + + G+KR L +D++ V E +++ L + + +
Sbjct: 189 ESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKR 248
Query: 67 EVLRA------------------------------------------------ENDAQKP 78
E+ +A + D K
Sbjct: 249 ELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKS 308
Query: 79 SLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYA 138
L +A+ K ++ L + L+ + + P L +I++ + D L Y A
Sbjct: 309 WLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTY----LWIGYLCA 364
Query: 139 TVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLL 198
+L LI + YF G+++R A+ +Y+KAL LSN+A + T G+ VNL+
Sbjct: 365 ILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLM 424
Query: 199 SNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLF 258
S D K VT F+H LW+ LQ + LW E+G S LAG+ V+++++P+ +
Sbjct: 425 SVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKS 484
Query: 259 SSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRG 318
+++ K D R++ MNE+++GI+I+K +AWE SF + + NLRKKE+ +L S L+
Sbjct: 485 KTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQC 544
Query: 319 MNLASFFSASKIIVFVTFTTYVLLGS--VITASRVFVAVTLYGAVRLTVTLFFPSAIERV 376
+ + F ++ VTF+ YVL+ S ++ A + F ++TL+ +R +++ P I +
Sbjct: 545 VVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSML-PMMISSM 603
Query: 377 SEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVR 436
+A VS R++ +L D++ + + K + + + W+ SE T++ ++ +
Sbjct: 604 LQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEA-TVRDVNLDIM 662
Query: 437 PGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFG 496
G+L+AV+GPVG+GKSSL+SA+LGE+ HG +++ G AYV QQ W+ +GT++ NILFG
Sbjct: 663 AGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFG 722
Query: 497 KKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIY 556
++ ++RY++V++ACAL DL++L GDL IG++G LSGGQK R++LARA YQ+ DIY
Sbjct: 723 TEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIY 782
Query: 557 LLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQK 614
LLDDPLSAVDA V +H+F + +L K +LVTH + +L +I++L +G +V+K
Sbjct: 783 LLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEK 842
Query: 615 GTYTEFLKSGIDFGSLLKK--------------DNEESEQ------------PPVPGTPT 648
G+Y+ L +F LK D E E P + T
Sbjct: 843 GSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASIT 902
Query: 649 LRN-----RTFSESSVWSQQ---SSRPSLKDGALES--QDTENVP--VTLSEENRSEGKV 696
+R RT S SS + + S R SLK + S +D E V + +E GKV
Sbjct: 903 MRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKV 962
Query: 697 GFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVT 756
F Y Y +A + +F F+IL VA++ + WLS W + + N T
Sbjct: 963 KFSIYLEYLQAIGLFSIF-FIILAFVMNSVAFIGSNLWLSAWTSDSKIFNST----DYPA 1017
Query: 757 EKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRN 816
+ D+ +G+Y L +A +F + V++S LH ++ +IL+AP+ FFD
Sbjct: 1018 SQRDMR--VGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTT 1075
Query: 817 PIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFI 876
P GRI+NRF+ DI +DD LP + +I L ++ + + P I ++PLGII++
Sbjct: 1076 PTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYV 1135
Query: 877 FLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSE 936
++ +++ TSR ++RL+S TRSP++SH S ++ GL IRA++ ++R + + D + +
Sbjct: 1136 SVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQK 1195
Query: 937 AWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWC 996
F ++T++RW A+RL+ + + V A +I TL VG LS AL + W
Sbjct: 1196 CVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWL 1255
Query: 997 VRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPL 1056
VR ++E+E +++VER+ EYT +E EAPW KRPPP WP +G I F+N Y P L
Sbjct: 1256 VRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDL 1315
Query: 1057 VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPE-GKIWIDKILTTEIGLHDLRK 1115
VL+ +T I S EK+G+VGRTGAGKSSL + LFR+ E G+I ID + IGLHDLR+
Sbjct: 1316 VLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLRE 1375
Query: 1116 KMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGS 1175
K++IIPQ+P+LF+G++R NLDPFN ++DEE+W AL+ LK + L + E+ E+G
Sbjct: 1376 KLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGG 1435
Query: 1176 NFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRL 1235
N S+GQRQL+CL RA+LRK++IL++DEATA VD TD LIQ I+ +FAHCTV+TIAHRL
Sbjct: 1436 NLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRL 1495
Query: 1236 NTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLG 1277
+TI+DSDK+MVLD+G++ E P LLQ FY M ++ G
Sbjct: 1496 HTIMDSDKVMVLDNGKIIECGSPEELLQ-IPGPFYFMAKEAG 1536
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 795 bits (2053), Expect = 0.0
Identities = 473/1349 (35%), Positives = 749/1349 (55%), Gaps = 96/1349 (7%)
Query: 6 QEVKPNPLQD--ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGF 63
+ V PNP + A SR+FFWW + G++ LEE D++S+ EDRSQ + ++L
Sbjct: 200 KNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEA 259
Query: 64 WDKE-----------------------VLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTL 100
W K+ +L A +KPS +A++ + S+L+ F L
Sbjct: 260 WRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKL 319
Query: 101 IEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
I++ I P L +I + N PM + A ++ C+++ +++ Y++++
Sbjct: 320 IQDLLSFINPQLLSILIRFISN--PM--APSWWGFLVAGLMFLCSMMQSLILQHYYHYIF 375
Query: 161 CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL 220
G++ R + +IYRKAL ++N +T G+IVNL+S D +F + FL+ LW+ PL
Sbjct: 376 VTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPL 435
Query: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
Q I LW +G S LAG+A +++L+PL + + K D+RI+ M+E++
Sbjct: 436 QIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEIL 495
Query: 281 TGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYV 340
GI+++K+YAWE SF + +R+ E+ + ++ L ++ + ++ +T YV
Sbjct: 496 NGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYV 555
Query: 341 LL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQR 398
+ +V+ A + FV+V+L+ +RL + + P I +++A VS++RIQ FL +E+ +
Sbjct: 556 YVDPNNVLDAEKAFVSVSLFNILRLPLNML-PQLISNLTQASVSLKRIQQFLSQEELDPQ 614
Query: 399 N--RQLPSDGKKM-VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLL 455
+ R+ S G + +H FT D PTL L V G L+AVVGPVG GKSSL+
Sbjct: 615 SVERKTISPGYAITIHSGTFTWAQDLP---PTLHSLDIQVPKGALVAVVGPVGCGKSSLV 671
Query: 456 SAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKK 515
SA+LGE+ G V + G +AYV QQ W+ + TL+ N+LFGK +RY++ ++ACAL
Sbjct: 672 SALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLA 731
Query: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
DL++L GD T IG++G LSGGQ+ RV+LARAVY DADI+LLDDPLSAVD+ V++H+F+
Sbjct: 732 DLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFD 791
Query: 576 LCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKK 633
I +L K +LVTH + +L I++L DG++ + G Y L+ F + L
Sbjct: 792 HVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCN 851
Query: 634 DNEESEQPPVPGT----------------PTLRNRT---------FSESSVWSQQSSRPS 668
+ +Q + + TL N T + + +Q S S
Sbjct: 852 YAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALS 911
Query: 669 LKDGALESQD--------TENVPVT--------LSEENRSEGKVGFQAYKNYFRAGAHWI 712
DG + + +E V VT EE + G V + +Y +A
Sbjct: 912 -SDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKA-VGLC 969
Query: 713 VFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLT 772
+ + LL A + + WLS W N +M + N N + +L + LGI G
Sbjct: 970 TTLAICLLYVGQSAAAIGANVWLSAWTN-DAMADSRQN---NTSLRLGVYAALGILQGFL 1025
Query: 773 VATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHL 832
V +A + +++ LH + + +++P FFD P GRILN FSKDI +
Sbjct: 1026 VMLAAMAMAAGG------IQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVV 1079
Query: 833 DDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRL 892
D++L L + + + + V +A P + ++PL +++ ++R++ TSR +KRL
Sbjct: 1080 DEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRL 1139
Query: 893 ESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRL 952
ES +RSP++SH S ++ G IRAY + + D D + + + ++ ++RW ++ +
Sbjct: 1140 ESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGV 1199
Query: 953 DAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVER 1012
+ + V+ A ++I +L+ G VGL++SY+L + W +R +++E+ +++VER
Sbjct: 1200 EFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVER 1259
Query: 1013 VIEYTDLEKEAPWEYQ-KRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKV 1071
V EY+ E EAPW + RPP WP G + F N + Y PG LVL+ L+ + EKV
Sbjct: 1260 VKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKV 1319
Query: 1072 GIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGT 1130
GIVGRTGAGKSS+ LFR+ E +G+I ID + +IGLHDLR +++IIPQ+P+LF+GT
Sbjct: 1320 GIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGT 1379
Query: 1131 MRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARA 1190
+R NLDPF +++E++W AL+ L + P +D + +E G N SVGQRQLVCLARA
Sbjct: 1380 LRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARA 1439
Query: 1191 ILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSG 1250
+LRK++IL++DEATA +D TD LIQ IR +F CTVLTIAHRLNTI+D +++VLD G
Sbjct: 1440 LLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKG 1499
Query: 1251 RLKEYDEPYVLLQNKESLFYKMVQQLGKA 1279
+ E+D P L+ + +FY M + G A
Sbjct: 1500 VVAEFDSPANLIAAR-GIFYGMARDAGLA 1527
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 758 bits (1958), Expect = 0.0
Identities = 465/1348 (34%), Positives = 735/1348 (54%), Gaps = 109/1348 (8%)
Query: 1 MLPVYQ--EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
M+PV + PNP+ DA L S F WL P+ G+++RL D + + D S +
Sbjct: 32 MIPVRPCARLAPNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAK 91
Query: 59 ELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFL-GKII 117
+ WD+EV R +K SL+ + K L+ + ++ I P+ L +I+
Sbjct: 92 RFRVLWDEEVARV--GPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQIL 149
Query: 118 NYFENYDPMDSVALNTAYA-YATVLT---FCTLILAILHHLYFYHVQCAGMRLRVAMCHM 173
E V + A +AT T F L AI + +RL+VA+ +
Sbjct: 150 QQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYR--------TAIRLKVALSTL 201
Query: 174 IYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEI 233
++ + + + G+++N+LS+D + +F P+ + A + +
Sbjct: 202 VFENLVSFKTLT--HISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFIL 259
Query: 234 GISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEK 293
G + L G++V +I +P+Q KL S+ R TD R++TMNE +T IR+IKMYAWEK
Sbjct: 260 GPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEK 319
Query: 294 SFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFV 353
SF+N I ++R++E + ++ ++ N A S I + +T + ++LL +TA F
Sbjct: 320 SFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFS 379
Query: 354 AVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQ 413
+ ++ ++ ++ + P +I+ ++EA VS+RR++ +L+D+ P D ++ +
Sbjct: 380 VIAMFNVMKFSIAIL-PFSIKAMAEANVSLRRMKK-ILIDKSPPSYITQPEDPDTVLLLA 437
Query: 414 DFTAFWD-KASETPT-------------------------------------------LQ 429
+ T W+ +AS T L
Sbjct: 438 NATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLH 497
Query: 430 GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTL 489
+SF VR G++L + G VG+GKSSLL+A+LG++ G+V+V+G +AYVSQQ W+F G +
Sbjct: 498 SISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNV 557
Query: 490 RSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAV 549
R NILFG+KY+ +RY+ ++ C L+KDL L GDLT IG+RG LSGGQ+ R++LARAV
Sbjct: 558 RENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAV 617
Query: 550 YQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDG 609
Y D +YLLDDPLSAVDA V +H+FE CI + L K +LVTHQLQ+L++ ++++L+DG
Sbjct: 618 YSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDG 677
Query: 610 KMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQS----- 664
++ +KGT+ E ++ + L+ + P F ES ++
Sbjct: 678 EICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIV 737
Query: 665 -SRPSLKDGALESQ-DTENVPVTLSE------ENRSEGKVGFQAYKNYFRAGAHWI---- 712
+ + KD ES+ +E V + E E+ EG V ++ Y Y +A ++
Sbjct: 738 LAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLF 797
Query: 713 -VFIFLILLNTAAQVAYVLQDWWLSYWANKQSML------NVTVNGGGNVTEKLDLNWYL 765
VF+FL+++ +AA +WWL W +K S + N T+ G V + + Y
Sbjct: 798 TVFLFLLMIGSAA-----FSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQ 852
Query: 766 GIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRF 825
+Y+ V ++FG+ + + + +S +LH+ +F+ ILK+P+ FFD P GR++NRF
Sbjct: 853 WVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRF 912
Query: 826 SKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLET 885
SKD+ LD LP +F+Q VV ++ + AV P + + + L + F L R F
Sbjct: 913 SKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRG 972
Query: 886 SRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTS 945
+++K++E+ +RSP F+H++SS+QGL I AY +E C + F
Sbjct: 973 VQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESC----------ITYHLLYFNCAL 1022
Query: 946 RWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVEN 1005
RWFA+R+D + + VA + ++ GL+LSY + L G+ Q CVR E +
Sbjct: 1023 RWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQA 1082
Query: 1006 MMISVERVIEYTDL---EKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLT 1062
SVE + EY E P + P WP G I F + Y PLVL L
Sbjct: 1083 KFTSVELLREYISTCVPECTHPLKVGTCPKD-WPSRGEITFRDYQMRYRDNTPLVLDSLN 1141
Query: 1063 ALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIP 1121
I+S + VGIVGRTG+GKSSL ALFRL EP G I+ID++ + L DLR K+++IP
Sbjct: 1142 LNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIP 1201
Query: 1122 QEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQ 1181
Q+PVLF GT+R NLDPF HTDE LW L+ +++TI LP K+ E+ E+G NFSVG+
Sbjct: 1202 QDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGE 1261
Query: 1182 RQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDS 1241
RQL+C+ARA+LR ++I+++DEATA++D +TD L+Q I++ F CTVLTIAHRLNT+++
Sbjct: 1262 RQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNC 1321
Query: 1242 DKIMVLDSGRLKEYDEPYVLLQNKESLF 1269
D ++V+++G++ E+D+P VL + +S F
Sbjct: 1322 DHVLVMENGKVIEFDKPEVLAEKPDSAF 1349
Score = 84.0 bits (206), Expect = 9e-16
Identities = 58/225 (25%), Positives = 118/225 (52%), Gaps = 22/225 (9%)
Query: 1057 VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKK 1116
VL ++ +++ + +GI G G+GKSSL++AL G++ + K G+ +
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALL------GQMQLQK------GVVAVNGT 542
Query: 1117 MSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSN 1176
++ + Q+ +F G +R+N+ ++ + + ++ L++ + +LP TE+ E G N
Sbjct: 543 LAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLN 602
Query: 1177 FSVGQRQLVCLARAILRKNQILIIDEATANVDPRT-----DELIQKKIREKFAHCTVLTI 1231
S GQRQ + LARA+ Q+ ++D+ + VD +E I+K +R K TV+ +
Sbjct: 603 LSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGK----TVVLV 658
Query: 1232 AHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQL 1276
H+L + D++++L+ G + E L++ + + K++ L
Sbjct: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEER-GRYAKLIHNL 702
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 755 bits (1950), Expect = 0.0
Identities = 470/1354 (34%), Positives = 731/1354 (53%), Gaps = 155/1354 (11%)
Query: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
L W KE + K PSL +
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
Query: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL-PMVISSIVQA 609
Query: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
Query: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
G L+AVVG VG GKSSLLSA+L E+ G V++ G +AYV QQ W+ + +LR NILF
Sbjct: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILF 728
Query: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
G + E+ Y VI+ACAL DL++L GDR
Sbjct: 729 GCQLEEPYYRSVIQACALLPDLEILPS------GDRTE---------------------- 760
Query: 556 YLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKG 615
+ EK ILVTH + YL I+++ GK+ + G
Sbjct: 761 --------------------------IGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMG 794
Query: 616 TYTEFLKSGIDFGSLLK--------KDNEESEQPPVPG----TPTLRN------------ 651
+Y E L F L+ +D EE+ V G + N
Sbjct: 795 SYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQL 854
Query: 652 -RTFSESSVWSQQSSRPSLKDGALESQDTENVPV-TLSEENRSE-GKVGFQAYKNYFRAG 708
R S SS +S SR L+ + + L E ++++ G+V Y +Y +A
Sbjct: 855 QRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAI 914
Query: 709 AHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNWYL 765
+I F IFL + N + +A ++WLS W + + VNG T+ +L + L
Sbjct: 915 GLFISFLSIFLFMCNHVSALA---SNYWLSLWTD-----DPIVNGTQEHTKVRLSVYGAL 966
Query: 766 GIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRF 825
GI G+ V FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++NRF
Sbjct: 967 GISQGIAV----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1020
Query: 826 SKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLET 885
SK++ +D ++P F+ +L V+G V + P AI + PLG+I+ F++R+++ +
Sbjct: 1021 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1080
Query: 886 SRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTS 945
SR +KRLES +RSPV+SH + +L G+ IRA++ +ER D D + +A++ + +
Sbjct: 1081 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1140
Query: 946 RWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVEN 1005
RW AVRL+ + V+ A ++I +L AG VGL++SY+L + W VR S+E+E
Sbjct: 1141 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1200
Query: 1006 MMISVERVIEYTDLEKEAPWEYQKRPPPA-WPHEGVIIFDNVNFMYSPGGPLVLKHLTAL 1064
+++VER+ EY++ EKEAPW+ Q+ PP+ WP G + F N Y VL+H+
Sbjct: 1201 NIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVT 1260
Query: 1065 IKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQE 1123
I EKVGIVGRTGAGKSSL LFR++E EG+I ID I +IGLHDLR K++IIPQ+
Sbjct: 1261 INGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQD 1320
Query: 1124 PVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQ 1183
PVLF+G++R NLDPF++++DEE+W +L+ LK+ + LP K+D E AE G N SVGQRQ
Sbjct: 1321 PVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQ 1380
Query: 1184 LVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDK 1243
LVCLARA+LRK +IL++DEATA VD TD+LIQ IR +F CTVLTIAHRLNTI+D +
Sbjct: 1381 LVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTR 1440
Query: 1244 IMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLG 1277
++VLD G ++EY P LLQ + LFY M + G
Sbjct: 1441 VIVLDKGEIQEYGAPSDLLQQR-GLFYSMAKDAG 1473
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 736 bits (1901), Expect = 0.0
Identities = 467/1356 (34%), Positives = 730/1356 (53%), Gaps = 162/1356 (11%)
Query: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
L W KE + K PSL +
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
Query: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL-PMVISSIVQA 609
Query: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
Query: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
G L+A V+G++ G +S++L
Sbjct: 669 PEGALVA---------------VVGQV------------------------GCGKSSLLS 689
Query: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
E ++ E G + + +G LSGGQK RV+LARAVY +ADI
Sbjct: 690 ALLAEMDKVE-----------------GHVAI---KGVNLSGGQKQRVSLARAVYSNADI 729
Query: 556 YLLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
YL DDPLSAVDA V +H+FE I +L K ILVTH + YL I+++ GK+ +
Sbjct: 730 YLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISE 789
Query: 614 KGTYTEFLKSGIDFGSLLK--------KDNEESEQPPVPG----TPTLRN---------- 651
G+Y E L F L+ +D EE+ V G + N
Sbjct: 790 MGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK 849
Query: 652 ---RTFSESSVWSQQSSRPSLKDGALESQDTENVPV-TLSEENRSE-GKVGFQAYKNYFR 706
R S SS +S SR L+ + + L E ++++ G+V Y +Y +
Sbjct: 850 QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMK 909
Query: 707 AGAHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNW 763
A +I F IFL + N + +A ++WLS W + + VNG T+ +L +
Sbjct: 910 AIGLFISFLSIFLFMCNHVSALA---SNYWLSLWTD-----DPIVNGTQEHTKVRLSVYG 961
Query: 764 YLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILN 823
LGI G+ V FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++N
Sbjct: 962 ALGISQGIAV----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVN 1015
Query: 824 RFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFL 883
RFSK++ +D ++P F+ +L V+G V + P AI + PLG+I+ F++R+++
Sbjct: 1016 RFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYV 1075
Query: 884 ETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLT 943
+SR +KRLES +RSPV+SH + +L G+ IRA++ +ER D D + +A++ +
Sbjct: 1076 ASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIV 1135
Query: 944 TSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEV 1003
+RW AVRL+ + V+ A ++I +L AG VGL++SY+L + W VR S+E+
Sbjct: 1136 ANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEM 1195
Query: 1004 ENMMISVERVIEYTDLEKEAPWEYQKRPPPA-WPHEGVIIFDNVNFMYSPGGPLVLKHLT 1062
E +++VER+ EY++ EKEAPW+ Q+ PP+ WP G + F N Y VL+H+
Sbjct: 1196 ETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHIN 1255
Query: 1063 ALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIP 1121
I EKVGIVGRTGAGKSSL LFR++E EG+I ID I +IGLHDLR K++IIP
Sbjct: 1256 VTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIP 1315
Query: 1122 QEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQ 1181
Q+PVLF+G++R NLDPF++++DEE+W +L+ LK+ + LP K+D E AE G N SVGQ
Sbjct: 1316 QDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQ 1375
Query: 1182 RQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDS 1241
RQLVCLARA+LRK +IL++DEATA VD TD+LIQ IR +F CTVLTIAHRLNTI+D
Sbjct: 1376 RQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDY 1435
Query: 1242 DKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLG 1277
+++VLD G ++EY P LLQ + LFY M + G
Sbjct: 1436 TRVIVLDKGEIQEYGAPSDLLQQR-GLFYSMAKDAG 1470
Score = 42.7 bits (99), Expect = 0.002
Identities = 29/119 (24%), Positives = 56/119 (47%), Gaps = 4/119 (3%)
Query: 1165 KMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKI---RE 1221
K++ +A G N S GQ+Q V LARA+ I + D+ + VD + I + + +
Sbjct: 697 KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756
Query: 1222 KFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAE 1280
+ T + + H ++ + D I+V+ G++ E Y L ++ F + ++ E
Sbjct: 757 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGS-YQELLARDGAFAEFLRTYASTE 814
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 733 bits (1892), Expect = 0.0
Identities = 445/1258 (35%), Positives = 698/1258 (55%), Gaps = 102/1258 (8%)
Query: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
L W KE + K PSL +
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
Query: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL-PMVISSIVQA 609
Query: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
Query: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
G L+AVVG VG GKSSLLSA+L E+ G V++ G +AYV QQ W+ + +LR NILF
Sbjct: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILF 728
Query: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
G + E+ Y VI+ACAL DL++L GD T IG++G LSGGQK RV+LARAVY +ADI
Sbjct: 729 GCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADI 788
Query: 556 YLLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
YL DDPLSAVDA V +H+FE I +L K ILVTH + YL I+++ GK+ +
Sbjct: 789 YLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISE 848
Query: 614 KGTYTEFLKSGIDFGSLLK--------KDNEESEQPPVPG----TPTLRN---------- 651
G+Y E L F L+ +D EE+ V G + N
Sbjct: 849 MGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK 908
Query: 652 ---RTFSESSVWSQQSSRPSLKDGALESQDTENVPV-TLSEENRSE-GKVGFQAYKNYFR 706
R S SS +S SR L+ + + L E ++++ G+V Y +Y +
Sbjct: 909 QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMK 968
Query: 707 AGAHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNW 763
A +I F IFL + N + +A ++WLS W + + VNG T+ +L +
Sbjct: 969 AIGLFISFLSIFLFMCNHVSALA---SNYWLSLWTD-----DPIVNGTQEHTKVRLSVYG 1020
Query: 764 YLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILN 823
LGI G+ V FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++N
Sbjct: 1021 ALGISQGIAV----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVN 1074
Query: 824 RFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFL 883
RFSK++ +D ++P F+ +L V+G V + P AI + PLG+I+ F++R+++
Sbjct: 1075 RFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYV 1134
Query: 884 ETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLT 943
+SR +KRLES +RSPV+SH + +L G+ IRA++ +ER D D + +A++ +
Sbjct: 1135 ASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIV 1194
Query: 944 TSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEV 1003
+RW AVRL+ + V+ A ++I +L AG VGL++SY+L + W VR S+E+
Sbjct: 1195 ANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEM 1254
Query: 1004 ENMMISVERVIEYTDLEKEAPWEYQK-RPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLT 1062
E +++VER+ EY++ EKEAPW+ Q+ PP +WP G + F N Y VL+H+
Sbjct: 1255 ETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHIN 1314
Query: 1063 ALIKSQEKVGIVGRTGAGKSSLISALFRLSE-PEGKIWIDKILTTEIGLHDLRKKMSIIP 1121
I EKVGIVGRTGAGKSSL LFR++E EG+I ID I +IGLHDLR K++IIP
Sbjct: 1315 VTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIP 1374
Query: 1122 QEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSV 1179
Q+PVLF+G++R NLDPF++++DEE+W +L+ LK+ + LP K+D E AE G N V
Sbjct: 1375 QDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
Score = 82.8 bits (203), Expect = 2e-15
Identities = 69/278 (24%), Positives = 126/278 (45%), Gaps = 20/278 (7%)
Query: 1008 ISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKS 1067
+S++R+ + E+ P ++RP I N F ++ P L +T I
Sbjct: 611 VSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPE 670
Query: 1068 QEKVGIVGRTGAGKSSLISALF-RLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVL 1126
V +VG+ G GKSSL+SAL + + EG + I + ++ +PQ+ +
Sbjct: 671 GALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI-------------KGSVAYVPQQAWI 717
Query: 1127 FTGTMRKNLDPFNEHTDEELWNA-LQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLV 1185
++R+N+ F +E + + +Q L +E LP TE+ E G N S GQ+Q V
Sbjct: 718 QNDSLRENI-LFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRV 776
Query: 1186 CLARAILRKNQILIIDEATANVDPRTDELIQKKI---REKFAHCTVLTIAHRLNTIIDSD 1242
LARA+ I + D+ + VD + I + + + + T + + H ++ + D
Sbjct: 777 SLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVD 836
Query: 1243 KIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAE 1280
I+V+ G++ E Y L ++ F + ++ E
Sbjct: 837 VIIVMSGGKISEMGS-YQELLARDGAFAEFLRTYASTE 873
Score = 32.3 bits (72), Expect = 3.1
Identities = 15/35 (42%), Positives = 22/35 (62%), Gaps = 1/35 (2%)
Query: 1243 KIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLG 1277
+++VLD G ++EY P LLQ + LFY M + G
Sbjct: 1431 RVIVLDKGEIQEYGAPSDLLQQR-GLFYSMAKDAG 1464
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 703 bits (1815), Expect = 0.0
Identities = 451/1317 (34%), Positives = 698/1317 (52%), Gaps = 86/1317 (6%)
Query: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69
P PL +A L S + WL PL + RL+E+ + + D S + L W++EV
Sbjct: 83 PQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVS 142
Query: 70 RAENDAQKPSLTRAIIKCYWKSYLV----LGIFTLIEESAKVIQPIFL-GKIINYFENYD 124
R +K S+ +++ + ++ L+ LGI I A V+ PI + KI+ Y E +
Sbjct: 143 R--RGIEKASVLLVMLR-FQRTRLIFDALLGICFCI---ASVLGPILIIPKILEYSE--E 194
Query: 125 PMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNM 184
+ +V +A L+ C L+ Q +R R A+ + K ++ ++
Sbjct: 195 QLGNVVHGVGLCFALFLSECVKSLSFSSSWIIN--QRTAIRFRAAVSSFAFEKLIQFKSV 252
Query: 185 AMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALL------WMEIGISCL 238
T+G+ ++ + DVN + + GPL I +L+ + IG +
Sbjct: 253 I--HITSGEAISFFTGDVNYLFEGVCY------GPLVLITCASLVICSISSYFIIGYTAF 304
Query: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298
+ +++ PL ++ + T+ +D RIR +EV+T I++IKMY WEK F+ +
Sbjct: 305 IAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKI 364
Query: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
I +LR+KE + + ++ + + F + V + L +TAS F +
Sbjct: 365 IEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASL 424
Query: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418
+RL+V F P A++ ++ + ++ R + F L + + L K +V ++ T
Sbjct: 425 NLLRLSV-FFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVF-EEATLS 482
Query: 419 WDK-----------------ASET------------------PTLQGLSFTVRPGELLAV 443
W + ASE P L ++ V G +L V
Sbjct: 483 WQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGV 542
Query: 444 VGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
G G+GKSSLLSA+L E+ G V V G +AYV QQ W+ SG +R NIL G Y+K R
Sbjct: 543 CGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKAR 602
Query: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
Y +V+ C+L +DL+LL GD+T IG+RG LSGGQK R++LARAVY D IYLLDDPLS
Sbjct: 603 YLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLS 662
Query: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
AVDA V +H+FE CI + L K +LVTHQLQYL+ QI++L++GK+ + GT++E ++
Sbjct: 663 AVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK 722
Query: 624 GIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGAL-ESQDTENV 682
+ L++K ++E+ + T + + ES + S SL A+ E Q T+
Sbjct: 723 KGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALA-TSLEESLNGNAVPEHQLTQ-- 779
Query: 683 PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYW---- 738
EE EG + ++ Y +Y +A ++V + + WWLSYW
Sbjct: 780 -----EEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQG 834
Query: 739 --ANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT 796
N N T+ GN+ + L++Y +Y + + G+ S + V +S
Sbjct: 835 SGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTA 894
Query: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSV 856
LHNK+F + + P+ FFD PIGR+LN F+ D+ LD LLP+ F+ L V+ V+ +
Sbjct: 895 LHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLI 954
Query: 857 AVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRA 916
+ P+I + + +I F + KRLE+ +RSP+FSH+ +SLQGL +I
Sbjct: 955 VSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHV 1014
Query: 917 YKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVA-FGSLILAKTLD 975
Y E F D + LFL+++RW A+RL+ + + + VA F + ++ T
Sbjct: 1015 YGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPY 1074
Query: 976 AGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDL-EKEAPWEYQKRP-PP 1033
+ +V +A++ L L FQ R E E +VER+++Y + EAP + P
Sbjct: 1075 SFKV-MAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQ 1133
Query: 1034 AWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
WP G IIF + + Y P VL + I+ E VGIVGRTG+GKSSL ALFRL E
Sbjct: 1134 GWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVE 1193
Query: 1094 P-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQE 1152
P G+I ID + IGL DLR K+S+IPQ+PVL +GT+R NLDPF+ HTD+++W+AL+
Sbjct: 1194 PMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALER 1253
Query: 1153 VQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTD 1212
L + I P K+ T++ E+G NFSVG+RQL+C+ARA+LR ++I++IDEATA++D TD
Sbjct: 1254 TFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETD 1313
Query: 1213 ELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLF 1269
LIQ+ IRE F CTVL IAHR+ T+++ D I+V+ +G++ E+D P VL + SLF
Sbjct: 1314 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1370
Score = 85.9 bits (211), Expect = 2e-16
Identities = 65/238 (27%), Positives = 119/238 (50%), Gaps = 23/238 (9%)
Query: 1058 LKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKM 1117
L + ++ +G+ G TG+GKSSL+SA+ +L +G+ +
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMH---------LLEGSVGVQG---SL 574
Query: 1118 SIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNF 1177
+ +PQ+ + +G +R+N+ + L L +E LP TE+ E G N
Sbjct: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
Query: 1178 SVGQRQLVCLARAILRKNQILIIDEATANVDPRT-----DELIQKKIREKFAHCTVLTIA 1232
S GQ+Q + LARA+ QI ++D+ + VD +E I+K +R K TV+ +
Sbjct: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK----TVVLVT 690
Query: 1233 HRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGK-AEAAALTETAK 1289
H+L + +I++L++G++ E L+Q K+ + +++Q++ K A + L +TAK
Sbjct: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQ-KKGKYAQLIQKMHKEATSDMLQDTAK 747
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 703 bits (1815), Expect = 0.0
Identities = 451/1317 (34%), Positives = 698/1317 (52%), Gaps = 86/1317 (6%)
Query: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69
P PL +A L S + WL PL + RL+E+ + + D S + L W++EV
Sbjct: 83 PQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVS 142
Query: 70 RAENDAQKPSLTRAIIKCYWKSYLV----LGIFTLIEESAKVIQPIFL-GKIINYFENYD 124
R +K S+ +++ + ++ L+ LGI I A V+ PI + KI+ Y E +
Sbjct: 143 R--RGIEKASVLLVMLR-FQRTRLIFDALLGICFCI---ASVLGPILIIPKILEYSE--E 194
Query: 125 PMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNM 184
+ +V +A L+ C L+ Q +R R A+ + K ++ ++
Sbjct: 195 QLGNVVHGVGLCFALFLSECVKSLSFSSSWIIN--QRTAIRFRAAVSSFAFEKLIQFKSV 252
Query: 185 AMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALL------WMEIGISCL 238
T+G+ ++ + DVN + + GPL I +L+ + IG +
Sbjct: 253 I--HITSGEAISFFTGDVNYLFEGVCY------GPLVLITCASLVICSISSYFIIGYTAF 304
Query: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298
+ +++ PL ++ + T+ +D RIR +EV+T I++IKMY WEK F+ +
Sbjct: 305 IAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKI 364
Query: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
I +LR+KE + + ++ + + F + V + L +TAS F +
Sbjct: 365 IEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASL 424
Query: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418
+RL+V F P A++ ++ + ++ R + F L + + L K +V ++ T
Sbjct: 425 NLLRLSV-FFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVF-EEATLS 482
Query: 419 WDK-----------------ASET------------------PTLQGLSFTVRPGELLAV 443
W + ASE P L ++ V G +L V
Sbjct: 483 WQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGV 542
Query: 444 VGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
G G+GKSSLLSA+L E+ G V V G +AYV QQ W+ SG +R NIL G Y+K R
Sbjct: 543 CGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKAR 602
Query: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
Y +V+ C+L +DL+LL GD+T IG+RG LSGGQK R++LARAVY D IYLLDDPLS
Sbjct: 603 YLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLS 662
Query: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
AVDA V +H+FE CI + L K +LVTHQLQYL+ QI++L++GK+ + GT++E ++
Sbjct: 663 AVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK 722
Query: 624 GIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGAL-ESQDTENV 682
+ L++K ++E+ + T + + ES + S SL A+ E Q T+
Sbjct: 723 KGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALA-TSLEESLNGNAVPEHQLTQ-- 779
Query: 683 PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYW---- 738
EE EG + ++ Y +Y +A ++V + + WWLSYW
Sbjct: 780 -----EEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQG 834
Query: 739 --ANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT 796
N N T+ GN+ + L++Y +Y + + G+ S + V +S
Sbjct: 835 SGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTA 894
Query: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSV 856
LHNK+F + + P+ FFD PIGR+LN F+ D+ LD LLP+ F+ L V+ V+ +
Sbjct: 895 LHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLI 954
Query: 857 AVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRA 916
+ P+I + + +I F + KRLE+ +RSP+FSH+ +SLQGL +I
Sbjct: 955 VSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHV 1014
Query: 917 YKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVA-FGSLILAKTLD 975
Y E F D + LFL+++RW A+RL+ + + + VA F + ++ T
Sbjct: 1015 YGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPY 1074
Query: 976 AGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDL-EKEAPWEYQKRP-PP 1033
+ +V +A++ L L FQ R E E +VER+++Y + EAP + P
Sbjct: 1075 SFKV-MAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQ 1133
Query: 1034 AWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
WP G IIF + + Y P VL + I+ E VGIVGRTG+GKSSL ALFRL E
Sbjct: 1134 GWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVE 1193
Query: 1094 P-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQE 1152
P G+I ID + IGL DLR K+S+IPQ+PVL +GT+R NLDPF+ HTD+++W+AL+
Sbjct: 1194 PMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALER 1253
Query: 1153 VQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTD 1212
L + I P K+ T++ E+G NFSVG+RQL+C+ARA+LR ++I++IDEATA++D TD
Sbjct: 1254 TFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETD 1313
Query: 1213 ELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLF 1269
LIQ+ IRE F CTVL IAHR+ T+++ D I+V+ +G++ E+D P VL + SLF
Sbjct: 1314 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1370
Score = 85.9 bits (211), Expect = 2e-16
Identities = 65/238 (27%), Positives = 119/238 (50%), Gaps = 23/238 (9%)
Query: 1058 LKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKM 1117
L + ++ +G+ G TG+GKSSL+SA+ +L +G+ +
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMH---------LLEGSVGVQG---SL 574
Query: 1118 SIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNF 1177
+ +PQ+ + +G +R+N+ + L L +E LP TE+ E G N
Sbjct: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
Query: 1178 SVGQRQLVCLARAILRKNQILIIDEATANVDPRT-----DELIQKKIREKFAHCTVLTIA 1232
S GQ+Q + LARA+ QI ++D+ + VD +E I+K +R K TV+ +
Sbjct: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK----TVVLVT 690
Query: 1233 HRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGK-AEAAALTETAK 1289
H+L + +I++L++G++ E L+Q K+ + +++Q++ K A + L +TAK
Sbjct: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQ-KKGKYAQLIQKMHKEATSDMLQDTAK 747
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 686 bits (1770), Expect = 0.0
Identities = 452/1354 (33%), Positives = 707/1354 (52%), Gaps = 123/1354 (9%)
Query: 1 MLPVYQEVKPNPLQDA-NLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPED-RSQHLGE 58
+LP QE P +D + SR + WL PL G L + LP + +L
Sbjct: 161 LLPEDQE--PEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLAR 218
Query: 59 ELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIIN 118
Q W + L RA+ + + YL LG+ L+ P+ L ++
Sbjct: 219 VFQAHWQEGA----------RLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVG 268
Query: 119 YFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKA 178
+ E L+ YA L ++ A+L + Y Y V ++ R A+ +++Y KA
Sbjct: 269 FLEE----GQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKA 324
Query: 179 LRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCL 238
L+L + TG+ +NLL D + H W PLQ LL+ ++G++ +
Sbjct: 325 LQLGP---SRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFV 381
Query: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298
G+ + ++L+P+ + + DAR++ + E+++GIR+IK WE++
Sbjct: 382 GGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGAR 441
Query: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
+ R +E+ ++ L + + + +I V F TYVL+G +TA++VF A+ L
Sbjct: 442 VEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVFTALALV 501
Query: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418
+ L + F P I + EA VS+ RIQ FL L + + P G+ ++
Sbjct: 502 RMLILPLNNF-PWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIK----- 555
Query: 419 WDKASETPT-------LQGLSFT----------------VRPGELLAVVGPVGAGKSSLL 455
W S+ P L G F+ V+ G L+ +VG VG GKSSLL
Sbjct: 556 WLLCSDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLL 615
Query: 456 SAVLGELAPSHGLVSVHGR---IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACA 512
+A+ GEL G V+V G +Q+PW+ T+R NILFGK ++ + Y++V++ACA
Sbjct: 616 AAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACA 675
Query: 513 LKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRH 572
L DL +L GD T +G++G TLSGGQ+AR+ LARAVYQ+ ++YLLDDPL+AVDA+V+ H
Sbjct: 676 LNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANH 735
Query: 573 LFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLK 632
L CI +L +L TH+ +YL+ A +L+++ G++++ G +E L
Sbjct: 736 LLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEIL----------- 784
Query: 633 KDNEESEQPPVPGTPTL--RNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEEN 690
P V P N S+S+ + K+G E Q T L EE+
Sbjct: 785 --------PLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEEEQSTSGR--LLQEES 834
Query: 691 RSEGKVGFQAYKNYFRAGAHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLN-- 746
+ EG V Y+ Y++A + +F +LL A + A DWWLS+W ++ N
Sbjct: 835 KKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNA---ADWWLSHWISQLKAENSS 891
Query: 747 ------------------VTVNGGGNV------------TEKLDLNWYLGIYSGLTVATV 776
+ + GN+ D+ +YL +Y+ +
Sbjct: 892 QEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNS 951
Query: 777 LFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLL 836
L + R++L + ++ TLH ++ +L APV FF+ P GRILNRFS D+ DD L
Sbjct: 952 LCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSL 1011
Query: 837 PLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTT 896
P + ++G+++V + +PW+ + L PL I++ ++R++ +SR+++RL S T
Sbjct: 1012 PFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLT 1071
Query: 897 RSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAIC 956
SP++SHL+ +L GL +RA A R +E +L+ F T +W +RL +
Sbjct: 1072 LSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMG 1131
Query: 957 AMFVIIVAFGSLILAKT--LDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVI 1014
A V +A +L+ + + G VGL+LSYAL+L G+ V + E M++SVER+
Sbjct: 1132 AAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLE 1191
Query: 1015 EYTDLEKEAPWEYQKRP---PPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKV 1071
EYT + P E Q +P W +G + F +V Y PG P L +T ++ EK+
Sbjct: 1192 EYTC---DLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKL 1248
Query: 1072 GIVGRTGAGKSSLISALFRLSEPE-GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGT 1130
GIVGRTG+GKSSL+ LFRL EP G++ +D + T+++ L LR +++IIPQEP LF+GT
Sbjct: 1249 GIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGT 1308
Query: 1131 MRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARA 1190
+R+NLDP H D LW AL++ L E I + G +D EL E G + S+GQRQL+CLARA
Sbjct: 1309 VRENLDPQGLHKDRALWQALKQCHLSEVITSMGG-LDGELGEGGRSLSLGQRQLLCLARA 1367
Query: 1191 ILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSG 1250
+L +IL IDEATA+VD +TD+L+Q+ I ++FA+ TVLTIAHRLNTI++SD+++VL +G
Sbjct: 1368 LLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAG 1427
Query: 1251 RLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAAL 1284
R+ E D P L SLF +++Q + A+L
Sbjct: 1428 RVVELDSPATLRNQPHSLFQQLLQSSQQGVPASL 1461
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 675 bits (1741), Expect = 0.0
Identities = 443/1327 (33%), Positives = 695/1327 (52%), Gaps = 86/1327 (6%)
Query: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFW--DKE 67
P P A S+ FWW++ L G++R L D++S+ E+ S+ L L+ W ++
Sbjct: 11 PCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRS 70
Query: 68 VLRAENDA---------------------QKPSLTRAIIKCYWK---SYLVLGIFTLIEE 103
R N A Q+ S R ++K W+ S +LG +LI
Sbjct: 71 AARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLI-- 128
Query: 104 SAKVIQPIF---LGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
I +F + K+++ F + Y A ++ + + Y ++
Sbjct: 129 ----ISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLK 184
Query: 161 CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL 220
MRLR A+ ++YRK L LS+ + + G +VNL+S DV + + ++L+ LW +
Sbjct: 185 VLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLV 244
Query: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
+ LW +G S L +AV + LLPL K + + + D+R R + ++
Sbjct: 245 WIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSIL 304
Query: 281 TGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYV 340
+ IK + WE +F + + +R +E+ + S L ++L SF ++ ++ V F +
Sbjct: 305 RNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHT 364
Query: 341 LLG-SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRN 399
L+ + + A + FV +T+ + F P +I + +A VS R+ TFL L+E+
Sbjct: 365 LVAENAMNAEKAFVTLTVLNILN-KAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGA 423
Query: 400 RQLPSDG----KKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLL 455
S G K + +Q T W + S P L ++ TV G LLAVVGPVGAGKSSLL
Sbjct: 424 VDSSSSGSAAGKDCITIQSATFAWSQESP-PCLHRINLTVPQGCLLAVVGPVGAGKSSLL 482
Query: 456 SAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKK 515
SA+LGEL+ G VS+ G +AYV Q+ WV + ++ N+ FG++ + E+V++ACAL+
Sbjct: 483 SALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQP 542
Query: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
D+ +G T IG++G LSGGQK R++LARAVY+ A +YLLDDPL+A+DA V +H+F
Sbjct: 543 DVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFN 602
Query: 576 LCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL-- 631
I +L ILVTH L L A I++L +G + + G+Y E L+ LL
Sbjct: 603 QVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQ 662
Query: 632 -KKDNEESEQPPVPGT-------------PTLRNRTFSESSVWSQQSSRPSLKDGALESQ 677
++ + E PGT P LR +S +++ + + L+
Sbjct: 663 ARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDP 722
Query: 678 DTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSY 737
D P +++ G+V + Y RA + ++ + L QVA + +WLS
Sbjct: 723 DRAGWPA--GKDSIQYGRVKATVHLAYLRAVGTPLC-LYALFLFLCQQVASFCRGYWLSL 779
Query: 738 WANKQSMLNVTVNGG--GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQ 795
WA+ ++ G + L +G+++ + A VL G AR+ S+
Sbjct: 780 WADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASM--AAVLLGGARA----------SR 827
Query: 796 TLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLP---LTFLDFIQTLLQVVG 852
L ++ ++++P+ FF+R PIG +LNRFSK+ +D +P + L + LL+V
Sbjct: 828 LLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSL 887
Query: 853 VVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLW 912
VV+VA P + ++PL +++ + ++ +S ++RLES + S V SH++ + QG
Sbjct: 888 VVAVAT---PLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGST 944
Query: 913 TIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAK 972
+RA++ + +A D F L RW A ++ + V A +++
Sbjct: 945 VVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKA 1004
Query: 973 TLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQK-RP 1031
L AG VG ++S AL + QW VR ++EN ++SVER+ +Y KEAPW
Sbjct: 1005 HLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAA 1064
Query: 1032 PPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRL 1091
P WP G I F + Y P PL ++ ++ I + EKVGIVGRTGAGKSSL S L RL
Sbjct: 1065 QPPWPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRL 1124
Query: 1092 SEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNAL 1150
E EG IWID + +GLH LR ++SIIPQ+P+LF G++R NLD EH+DE +W AL
Sbjct: 1125 QEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAAL 1184
Query: 1151 QEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPR 1210
+ VQLK + LPG++ + A+ G + SVGQ+QL+CLARA+LRK QILI+DEATA VDP
Sbjct: 1185 ETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPG 1244
Query: 1211 TDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFY 1270
T+ +Q + FA CTVL IAHRL +++D +++V+D G++ E P LL K LFY
Sbjct: 1245 TELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK-GLFY 1303
Query: 1271 KMVQQLG 1277
++ Q+ G
Sbjct: 1304 RLAQESG 1310
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 674 bits (1739), Expect = 0.0
Identities = 442/1331 (33%), Positives = 697/1331 (52%), Gaps = 86/1331 (6%)
Query: 6 QEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFW- 64
Q+ P P A S+ FWW++ L G++R L D++S+ E+ S+ L L+ W
Sbjct: 198 QQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 257
Query: 65 -DKEVLRAENDA---------------------QKPSLTRAIIKCYWK---SYLVLGIFT 99
++ R N A Q+ S R ++K W+ S +LG +
Sbjct: 258 RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLS 317
Query: 100 LIEESAKVIQPIF---LGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYF 156
LI I +F + K+++ F + Y A ++ + +
Sbjct: 318 LI------ISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNM 371
Query: 157 YHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLW 216
Y ++ MRLR A+ ++YRK L LS+ + + G +VNL+S DV + + ++L+ LW
Sbjct: 372 YRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLW 431
Query: 217 AGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM 276
+ + LW +G S L +AV + LLPL K + + + D+R R
Sbjct: 432 LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLT 491
Query: 277 NEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTF 336
+ ++ + IK + WE +F + + +R +E+ + S L ++L SF ++ ++ V F
Sbjct: 492 SSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVF 551
Query: 337 TTYVLLG-SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEI 395
+ L+ + + A + FV +T+ + F P +I + +A VS R+ TFL L+E+
Sbjct: 552 AVHTLVAENAMNAEKAFVTLTVLNILN-KAQAFLPFSIHSLVQARVSFDRLVTFLCLEEV 610
Query: 396 S----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
+ + GK + + T W + S P L ++ TV G LLAVVGPVGAGK
Sbjct: 611 DPGVVDSSSSGSAAGKDCITIHSATFAWSQESP-PCLHRINLTVPQGCLLAVVGPVGAGK 669
Query: 452 SSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKAC 511
SSLLSA+LGEL+ G VS+ G +AYV Q+ WV + ++ N+ FG++ + E+V++AC
Sbjct: 670 SSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEAC 729
Query: 512 ALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSR 571
AL+ D+ +G T IG++G LSGGQK R++LARAVY+ A +YLLDDPL+A+DA V +
Sbjct: 730 ALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQ 789
Query: 572 HLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGS 629
H+F I +L ILVTH L L A I++L +G + + G+Y E L+
Sbjct: 790 HVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVC 849
Query: 630 LL---KKDNEESEQPPVPGT-------------PTLRNRTFSESSVWSQQSSRPSLKDGA 673
LL ++ + E PGT P LR +S +++ + +
Sbjct: 850 LLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVP 909
Query: 674 LESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDW 733
L+ D P +++ G+V + Y RA + ++ + L QVA + +
Sbjct: 910 LDDPDRAGWPA--GKDSIQYGRVKATVHLAYLRAVGTPLC-LYALFLFLCQQVASFCRGY 966
Query: 734 WLSYWANKQSMLNVTVNGG--GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLV 791
WLS WA+ ++ G + L +G+++ + A VL G AR+
Sbjct: 967 WLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASM--AAVLLGGARA-------- 1016
Query: 792 NSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLP---LTFLDFIQTLL 848
S+ L ++ ++++P+ FF+R PIG +LNRFSK+ +D +P + L + LL
Sbjct: 1017 --SRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLL 1074
Query: 849 QVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSL 908
+V VV+VA P + ++PL +++ + ++ +S ++RLES + S V SH++ +
Sbjct: 1075 EVSLVVAVAT---PLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETF 1131
Query: 909 QGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSL 968
QG +RA++ + +A D F L RW A ++ + V A ++
Sbjct: 1132 QGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAV 1191
Query: 969 ILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQ 1028
+ L AG VG ++S AL + QW VR ++EN ++SVER+ +Y KEAPW
Sbjct: 1192 LSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLP 1251
Query: 1029 K-RPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISA 1087
P WP G I F + Y P PL ++ ++ I + EKVGIVGRTGAGKSSL S
Sbjct: 1252 TCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASG 1311
Query: 1088 LFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEEL 1146
L RL E EG IWID + +GLH LR ++SIIPQ+P+LF G++R NLD EH+DE +
Sbjct: 1312 LLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAI 1371
Query: 1147 WNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATAN 1206
W AL+ VQLK + LPG++ + A+ G + SVGQ+QL+CLARA+LRK QILI+DEATA
Sbjct: 1372 WAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAA 1431
Query: 1207 VDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKE 1266
VDP T+ +Q + FA CTVL IAHRL +++D +++V+D G++ E P LL K
Sbjct: 1432 VDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK- 1490
Query: 1267 SLFYKMVQQLG 1277
LFY++ Q+ G
Sbjct: 1491 GLFYRLAQESG 1501
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 665 bits (1715), Expect = 0.0
Identities = 437/1331 (32%), Positives = 707/1331 (53%), Gaps = 84/1331 (6%)
Query: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
Q+VKP LQD NL S+ +WW+N L HK+ ++ + + R+
Sbjct: 200 QKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVT 259
Query: 56 LGEELQGFWDKEVLR-AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
L+ ++++ + A++ + PS+ A+ + + + L+ F + + P+ +
Sbjct: 260 NYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCIS 319
Query: 115 KII-------NYFENYDPMDSVA-----LNTAYAYATVLTFCTLIL--AILHHLYFYHVQ 160
I+ N N + L AY A VL F LIL L Y+ ++
Sbjct: 320 GIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLA-VLLFLALILQRTFLQASYYVTIE 378
Query: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
G+ LR A+ MIY K LRLS N++MG+ T GQI NL++ + N+ LWA
Sbjct: 379 -TGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
Query: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
P+Q I LL+ +G S L G AV+++L P+Q + + T ++ R++ NE
Sbjct: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
Query: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
++ GI+++K+YAWE F + R KE+S + + +++ + V TF T
Sbjct: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
Query: 339 YVLL-GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVS-EAIVSIRRIQTFLLLDEIS 396
+ G+ + + F +++L+ L LF S + R + +AI+S++++ FLL DEI
Sbjct: 558 HAYASGNNLKPAEAFASLSLFHI--LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIG 615
Query: 397 QRN-----RQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
+ LP + K ++ S TL + + G+L +VG VG GK
Sbjct: 616 DDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGK 675
Query: 452 SSLLSAVLGELAPSHGLV-------------SVHGR----IAYVSQQPWVFSGTLRSNIL 494
SSLL A+LGE+ G V + R +AY +Q+PW+ + T+ NI
Sbjct: 676 SSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENIT 735
Query: 495 FGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDAD 554
FG + K+RY+ V AC+L+ D+ LL GD T IG+RG LSGGQ+ R+ +ARA+YQ+ +
Sbjct: 736 FGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTN 795
Query: 555 IYLLDDPLSAVDAEVSRHLFELCICQILHE--KITILVTHQLQYLKAASQILILKDGKMV 612
I LDDP SA+D +S HL + I + L + + +LVTH+LQYL A I+ +KDG ++
Sbjct: 796 IVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVL 855
Query: 613 QKGTYTEFLKSGID----FGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPS 668
++GT + ++ + +L+ + ++E E+ TL +T + + ++
Sbjct: 856 REGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMY--SREAKAQ 913
Query: 669 LKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHW--IVFIFLILLNTAAQV 726
++D E ++ E+ +S R K+ ++ Y +G + I+ IF LL + V
Sbjct: 914 MEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIV 973
Query: 727 AYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLV 786
A D+WL+ W ++ S+ N T K D +Y+ +S L A + + SL V
Sbjct: 974 AI---DYWLATWTSEYSINN---------TGKADQTYYVAGFSILCGAGIFLCLVTSLTV 1021
Query: 787 FYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQT 846
++ + +++ LH+ + I+ P+ FFD P+G ILNRFS D +D +P T ++
Sbjct: 1022 EWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRS 1081
Query: 847 LLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSS 906
L + + + P + L+PLG+ F F+++YF S+D++ L+ +T+ P+ H S
Sbjct: 1082 TLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSE 1141
Query: 907 SLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFG 966
+ +GL TIRA++ E R ++ D ++ A+ +RW VR D + A V+ +
Sbjct: 1142 TAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIA 1201
Query: 967 SLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWE 1026
S+ + + ++G VGL L YALT+ W VR A++E M +V++V + +E E +E
Sbjct: 1202 SI--SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESEN-YE 1258
Query: 1027 YQKRP---PPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSS 1083
P P WP EG I ++ Y VLKH+ A IK +KVGI GRTG+GKSS
Sbjct: 1259 GTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSS 1318
Query: 1084 LISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHT 1142
L A FR+ + +GKI ID I +++ LH LR ++SII Q+P+LF+G++R NLDP + T
Sbjct: 1319 LSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCT 1378
Query: 1143 DEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDE 1202
D+ LW AL+ QLK ++ LPG +D + E G NFSVGQRQL CLARA +RK+ ILI+DE
Sbjct: 1379 DDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDE 1438
Query: 1203 ATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLL 1262
ATA++D T+ ++QK + FA TV+TIAHR+++I+D+ ++V G L E D LL
Sbjct: 1439 ATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLL 1498
Query: 1263 QNKESLFYKMV 1273
+K LF +V
Sbjct: 1499 AHKNGLFSTLV 1509
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 661 bits (1705), Expect = 0.0
Identities = 437/1368 (31%), Positives = 712/1368 (52%), Gaps = 120/1368 (8%)
Query: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
Q+VKP LQD NL S+ +WW+N L HK+ ++ + + R+
Sbjct: 200 QKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVT 259
Query: 56 LGEELQGFWDKEVLR-AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
L+ ++++ + A++ + PS+ A+ + + + L+ F + + P+ +
Sbjct: 260 NYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCIS 319
Query: 115 KII-------NYFENYDPMDSVA-----LNTAYAYATVLTFCTLIL--AILHHLYFYHVQ 160
I+ N N + L AY A VL F LIL L Y+ ++
Sbjct: 320 GIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLA-VLLFLALILQRTFLQASYYVTIE 378
Query: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
G+ LR A+ MIY K LRLS N++MG+ T GQI NL++ + N+ LWA
Sbjct: 379 -TGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
Query: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
P+Q I LL+ +G S L G AV+++L P+Q + + T ++ R++ NE
Sbjct: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
Query: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
++ GI+++K+YAWE F + R KE+S + + +++ + V TF T
Sbjct: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
Query: 339 YVLL-GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVS-EAIVSIRRIQTFLLLDEIS 396
+ G+ + + F +++L+ L LF S + R + +AI+S++++ FLL DEI
Sbjct: 558 HAYASGNNLKPAEAFASLSLFHI--LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIG 615
Query: 397 -----------------------------------------QRNRQLPSDGKKMVHVQDF 415
Q R+L + + ++
Sbjct: 616 DDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVT 675
Query: 416 TAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV------ 469
++ S TL + + G+L +VG VG GKSSLL A+LGE+ G V
Sbjct: 676 NGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 735
Query: 470 -------SVHGR----IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQ 518
+ R +AY +Q+PW+ + T+ NI FG + K+RY+ V AC+L+ D+
Sbjct: 736 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDID 795
Query: 519 LLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCI 578
LL GD T IG+RG LSGGQ+ R+ +ARA+YQ+ +I LDDP SA+D +S HL + I
Sbjct: 796 LLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGI 855
Query: 579 CQILHE--KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGID----FGSLLK 632
+ L + + +LVTH+LQYL A I+ +KDG ++++GT + ++ + +L+
Sbjct: 856 LKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN 915
Query: 633 KDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRS 692
+ ++E E+ TL +T + + ++ ++D E ++ E+ +S R
Sbjct: 916 RQDQELEKDMEADQTTLERKTLRRAMY--SREAKAQMEDEDEEEEEEEDEDDNMSTVMRL 973
Query: 693 EGKVGFQAYKNYFRAGAHW--IVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVN 750
K+ ++ Y +G + I+ IF LL + VA D+WL+ W ++ S+ N
Sbjct: 974 RTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAI---DYWLATWTSEYSINN---- 1026
Query: 751 GGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPV 810
T K D +Y+ +S L A + + SL V ++ + +++ LH+ + I+ P+
Sbjct: 1027 -----TGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPI 1081
Query: 811 LFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVP 870
FFD P+G ILNRFS D +D +P T ++ L + + + P + L+P
Sbjct: 1082 RFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLP 1141
Query: 871 LGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAH 930
LG+ F F+++YF S+D++ L+ +T+ P+ H S + +GL TIRA++ E R ++
Sbjct: 1142 LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLEL 1201
Query: 931 QDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLM 990
D ++ A+ +RW VR D + A V+ + S+ + + ++G VGL L YALT+
Sbjct: 1202 TDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASI--SGSSNSGLVGLGLLYALTIT 1259
Query: 991 GMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRP---PPAWPHEGVIIFDNVN 1047
W VR A++E M +V++V + +E E +E P P WP EG I ++
Sbjct: 1260 NYLNWVVRNLADLEVQMGAVKKVNSFLTMESEN-YEGTMDPSQVPEHWPQEGEIKIHDLC 1318
Query: 1048 FMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTT 1106
Y VLKH+ A IK +KVGI GRTG+GKSSL A FR+ + +GKI ID I +
Sbjct: 1319 VRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDIS 1378
Query: 1107 EIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKM 1166
++ LH LR ++SII Q+P+LF+G++R NLDP + TD+ LW AL+ QLK ++ LPG +
Sbjct: 1379 KLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGL 1438
Query: 1167 DTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHC 1226
D + E G NFSVGQRQL CLARA +RK+ ILI+DEATA++D T+ ++QK + FA
Sbjct: 1439 DAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADR 1498
Query: 1227 TVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQ 1274
TV+TIAHR++TI+ +D ++V+ G + EYD P LL + +F V+
Sbjct: 1499 TVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVR 1546
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 654 bits (1688), Expect = 0.0
Identities = 437/1367 (31%), Positives = 710/1367 (51%), Gaps = 120/1367 (8%)
Query: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
Q+VKP LQD NL S+ +WW+N L HK+ ++ + + R+
Sbjct: 200 QKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVT 259
Query: 56 LGEELQGFWDKEVLR-AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
L+ ++++ + A++ + PS+ A+ + + + L+ F + + P+ +
Sbjct: 260 NYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCIS 319
Query: 115 KII-------NYFENYDPMDSVA-----LNTAYAYATVLTFCTLIL--AILHHLYFYHVQ 160
I+ N N + L AY A VL F LIL L Y+ ++
Sbjct: 320 GIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLA-VLLFLALILQRTFLQASYYVTIE 378
Query: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
G+ LR A+ MIY K LRLS N++MG+ T GQI NL++ + N+ LWA
Sbjct: 379 -TGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
Query: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
P+Q I LL+ +G S L G AV+++L P+Q + + T ++ R++ NE
Sbjct: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
Query: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
++ GI+++K+YAWE F + R KE+S + + +++ + V TF T
Sbjct: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
Query: 339 YVLL-GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVS-EAIVSIRRIQTFLLLDEIS 396
+ G+ + + F +++L+ L LF S + R + +AI+S++++ FLL DEI
Sbjct: 558 HAYASGNNLKPAEAFASLSLFHI--LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIG 615
Query: 397 -----------------------------------------QRNRQLPSDGKKMVHVQDF 415
Q R+L + + ++
Sbjct: 616 DDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVT 675
Query: 416 TAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV------ 469
++ S TL + + G+L +VG VG GKSSLL A+LGE+ G V
Sbjct: 676 NGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 735
Query: 470 -------SVHGR----IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQ 518
+ R +AY +Q+PW+ + T+ NI FG + K+RY+ V AC+L+ D+
Sbjct: 736 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDID 795
Query: 519 LLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCI 578
LL GD T IG+RG LSGGQ+ R+ +ARA+YQ+ +I LDDP SA+D +S HL + I
Sbjct: 796 LLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGI 855
Query: 579 CQILHE--KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGID----FGSLLK 632
+ L + + +LVTH+LQYL A I+ +KDG ++++GT + ++ + +L+
Sbjct: 856 LKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN 915
Query: 633 KDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRS 692
+ ++E E+ TL +T + + ++ ++D E ++ E+ +S R
Sbjct: 916 RQDQELEKDMEADQTTLERKTLRRAMY--SREAKAQMEDEDEEEEEEEDEDDNMSTVMRL 973
Query: 693 EGKVGFQAYKNYFRAGAHW--IVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVN 750
K+ ++ Y +G + I+ IF LL + VA D+WL+ W ++ S+ N
Sbjct: 974 RTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAI---DYWLATWTSEYSINN---- 1026
Query: 751 GGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPV 810
T K D +Y+ +S L A + + SL V ++ + +++ LH+ + I+ P+
Sbjct: 1027 -----TGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPI 1081
Query: 811 LFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVP 870
FFD P+G ILNRFS D +D +P T ++ L + + + P + L+P
Sbjct: 1082 RFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLP 1141
Query: 871 LGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAH 930
LG+ F F+++YF S+D++ L+ +T+ P+ H S + +GL TIRA++ E R ++
Sbjct: 1142 LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLEL 1201
Query: 931 QDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLM 990
D ++ A+ +RW VR D + A V+ + S+ + + ++G VGL L YALT+
Sbjct: 1202 TDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASI--SGSSNSGLVGLGLLYALTIT 1259
Query: 991 GMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRP---PPAWPHEGVIIFDNVN 1047
W VR A++E M +V++V + +E E +E P P WP EG I ++
Sbjct: 1260 NYLNWVVRNLADLEVQMGAVKKVNSFLTMESEN-YEGTMDPSQVPEHWPQEGEIKIHDLC 1318
Query: 1048 FMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTT 1106
Y VLKH+ A IK +KVGI GRTG+GKSSL A FR+ + +GKI ID I +
Sbjct: 1319 VRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDIS 1378
Query: 1107 EIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKM 1166
++ LH LR ++SII Q+P+LF+G++R NLDP + TD+ LW AL+ QLK ++ LPG +
Sbjct: 1379 KLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGL 1438
Query: 1167 DTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHC 1226
D + E G NFSVGQRQL CLARA +RK+ ILI+DEATA++D T+ ++QK + FA
Sbjct: 1439 DAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADR 1498
Query: 1227 TVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
TV+TIAHR+++I+D+ ++V G L E D LL +K LF +V
Sbjct: 1499 TVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 654 bits (1688), Expect = 0.0
Identities = 364/863 (42%), Positives = 525/863 (60%), Gaps = 31/863 (3%)
Query: 427 TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFS 486
TL + ++ G+L+ + G VG+GK+SL+SA+LG++ G +++ G AYV+QQ W+ +
Sbjct: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILN 636
Query: 487 GTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLA 546
TLR NILFGK+Y++ERY V+ +C L+ DL +L DLT IG+RG LSGGQ+ R++LA
Sbjct: 637 ATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA 696
Query: 547 RAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILIL 606
RA+Y D IY+LDDPLSA+DA V H+F I + L K + VTHQLQYL +++ +
Sbjct: 697 RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFM 756
Query: 607 KDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSR 666
K+G + ++GT+ E + D+ ++ + E PPV + ++ + S Q
Sbjct: 757 KEGCITERGTHEELMNLNGDYATIFN-NLLLGETPPVE----INSKKETSGSQKKSQDKG 811
Query: 667 PSL----KDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNT 722
P K+ A++ ++ + V + E + +G V + Y Y +A + F+ ++ L
Sbjct: 812 PKTGSVKKEKAVKPEEGQLVQL----EEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFM 867
Query: 723 AAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVT------EKLDLNWYLGIYSGLTVATV 776
+ WWLSYW KQ N TV G + + + +Y IY+ +
Sbjct: 868 LNVGSTAFSTWWLSYWI-KQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVML 926
Query: 777 LFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLL 836
+ R ++ + +S LH+++F IL++P+ FFD P GRILNRFSKD+ +D L
Sbjct: 927 ILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRL 986
Query: 837 PLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTT 896
P FIQ ++ V V + V PW + + PL I+F L R++KRL++ T
Sbjct: 987 PFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNIT 1046
Query: 897 RSPVFSHLSSSLQGLWTIRAY-KAEE---RCQELFDAHQDLHSEAWFLFLTTSRWFAVRL 952
+SP SH++SS+QGL TI AY K +E R QEL D +Q +FLF RW AVRL
Sbjct: 1047 QSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQ----APFFLFTCAMRWLAVRL 1102
Query: 953 DAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVER 1012
D I + +++ + GLA+SYA+ L G+FQ+ VR ++E E SVER
Sbjct: 1103 DLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVER 1162
Query: 1013 VIEYTD-LEKEAPWEYQ-KRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEK 1070
+ Y L EAP + K P P WP EG + F+N Y PLVLK ++ IK +EK
Sbjct: 1163 INHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEK 1222
Query: 1071 VGIVGRTGAGKSSLISALFRLSEPEGK-IWIDKILTTEIGLHDLRKKMSIIPQEPVLFTG 1129
+GIVGRTG+GKSSL ALFRL E G I ID + ++IGL DLR K+SIIPQEPVLF+G
Sbjct: 1223 IGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSG 1282
Query: 1130 TMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLAR 1189
T+R NLDPFN++T++++W+AL+ +KE I LP K+++E+ E+G NFSVG+RQL+C+AR
Sbjct: 1283 TVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIAR 1342
Query: 1190 AILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDS 1249
A+LR +ILI+DEATA +D TD LIQ+ IRE FA CT+LTIAHRL+T++ SD+IMVL
Sbjct: 1343 ALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQ 1402
Query: 1250 GRLKEYDEPYVLLQNKESLFYKM 1272
G++ E+D P VLL N S FY M
Sbjct: 1403 GQVVEFDTPSVLLSNDSSRFYAM 1425
Score = 144 bits (362), Expect = 7e-34
Identities = 108/419 (25%), Positives = 207/419 (49%), Gaps = 22/419 (5%)
Query: 11 NPLQDANLCSRVFFWWLNPLFKIGHKR-RLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69
+P+ +A L S + F WL+ L ++ HK+ L +D++S+ + S L+ W +E+
Sbjct: 99 HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELN 158
Query: 70 RAENDAQKPSLTRAIIKCYWKSYLVLGIFTL-IEESAKVIQPIFLGK-IINYFENYDPMD 127
DA R ++ + ++ L+L I L I + A P F+ K ++ Y +
Sbjct: 159 EVGPDAAS---LRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQ------ 209
Query: 128 SVALNTAYAYATVLTFCTLILAILHH----LYFYHVQCAGMRLRVAMCHMIYRKALRLSN 183
A + Y+ +L L+ I+ L + G+RLR A+ M ++K L+L N
Sbjct: 210 --ATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKN 267
Query: 184 MAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAV 243
+ + + G+++N+ SND + + L GP+ AI + +G + G AV
Sbjct: 268 IK--EKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAV 325
Query: 244 LIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLR 303
I+ P +L + R K TD R++ MNEV+T I+ IKMYAW K+FS + +R
Sbjct: 326 FILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIR 385
Query: 304 KKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRL 363
++E + ++ + + + I VTF+ ++ LG +TA++ F VT++ ++
Sbjct: 386 EEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTF 445
Query: 364 TVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKA 422
+ + P +++ +SEA V++ R ++ L++E+ + P+ + +++ T WD +
Sbjct: 446 ALKV-TPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNK-PASPHIKIEMKNATLAWDSS 502
Score = 89.7 bits (221), Expect = 2e-17
Identities = 113/510 (22%), Positives = 218/510 (42%), Gaps = 29/510 (5%)
Query: 137 YATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVN 196
YA++ ++ IL + +R + ++R+ LR T TG+I+N
Sbjct: 914 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILN 973
Query: 197 LLSNDVNKFDQVTVFLHFLWAGPLQ-AIAVTALLWMEIGIS--CLAGMAVLIILLPLQSC 253
S D+ D+V V L F +Q I V + M G+ L + L+IL +
Sbjct: 974 RFSKDM---DEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHI 1030
Query: 254 FGKLFSSLRSKTATFTDAR-IRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILR 312
++ + T + + + I G+ I Y + F + L +
Sbjct: 1031 VSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFL 1090
Query: 313 SSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSA 372
+C S ++ T VL+ I + +A++ AV+LT F
Sbjct: 1091 FTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISY--AVQLTGLFQFTVR 1148
Query: 373 IERVSEA-IVSIRRIQTF---LLLDEISQRNRQLPS-DGKKMVHVQDFTAFWDKASETP- 426
+ +EA S+ RI + L L+ ++ + PS D + V A P
Sbjct: 1149 LASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPL 1208
Query: 427 TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG------------- 473
L+ +SFT++P E + +VG G+GKSSL A+ + S G + + G
Sbjct: 1209 VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRS 1268
Query: 474 RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGT 533
+++ + Q+P +FSGT+RSN+ +Y +++ ++ +K+ + L + + + G
Sbjct: 1269 KLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGD 1328
Query: 534 TLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQ 593
S G++ + +ARA+ + I +LD+ +A+D E L + I + + + + H+
Sbjct: 1329 NFSVGERQLLCIARALLRHCKILILDEATAAMDTETDL-LIQETIREAFADCTMLTIAHR 1387
Query: 594 LQYLKAASQILILKDGKMVQKGTYTEFLKS 623
L + + +I++L G++V+ T + L +
Sbjct: 1388 LHTVLGSDRIMVLAQGQVVEFDTPSVLLSN 1417
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 643 bits (1658), Expect = 0.0
Identities = 438/1387 (31%), Positives = 704/1387 (50%), Gaps = 128/1387 (9%)
Query: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
+EVKP LQD NL S+ +WW+N K HK+ ++ + + R+
Sbjct: 202 REVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALT 261
Query: 56 LGEELQGFWDKEVLRAENDAQKP-SLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
+ L +D +V + Q ++ +A+ + + ++ F ++ + P+ +
Sbjct: 262 NYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIF 321
Query: 115 KIINYF--EN------------YDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
I+++ EN Y L AY A +L L+ +Y
Sbjct: 322 GIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAI 381
Query: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
G+ LR A+ IY K + LS N++MG+ T GQI NL++ D N+ LWA
Sbjct: 382 ETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAM 441
Query: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
P+Q I LL+ +G+S L G AV+I+L P+Q S + T +++ R++ NE
Sbjct: 442 PVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNE 501
Query: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
++ GI+++K+YAWE F + R+KE++ + + +++ + V +TF
Sbjct: 502 MLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVG 561
Query: 339 YVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEIS 396
+V + + S F +++L+ + +T S + +A+VS++++ FL EI
Sbjct: 562 HVSFFKEADFSPSVAFASLSLFH-ILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIR 620
Query: 397 QR------------------------NRQLPSDG---------KKMVHVQDFTA------ 417
+ NR+ P+ + +V D A
Sbjct: 621 EEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQ 680
Query: 418 -----FWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV--- 469
F PTL ++ + G+L +VG VG GKSSLL A LGE+ G V
Sbjct: 681 IMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWS 740
Query: 470 -----------------------SVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEK 506
G +AY SQ+PW+ + T+ NI+F + K+RY+
Sbjct: 741 SLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKM 800
Query: 507 VIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVD 566
VI+AC+L+ D+ +L GD T IG+RG LSGGQ+ R+++ARA+YQ A++ LDDP SA+D
Sbjct: 801 VIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALD 860
Query: 567 AEVSRHLFELCICQILHE--KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSG 624
+S HL + I ++L + + +LVTH+LQYL A I+ +KDG + ++GT +F +S
Sbjct: 861 IHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE 920
Query: 625 ID----FGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTE 680
+ +L+ + ++E E+ V T R T + SSR DG L+ ++ E
Sbjct: 921 CQLFEHWKTLMNRQDQELEKETV----TERKATEPPQGLSRAMSSR----DGLLQDEEEE 972
Query: 681 NVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAA------QVAYVLQDWW 734
SEE+ + + Q + +RA A ++ ++LL+ + V D+W
Sbjct: 973 EEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYW 1032
Query: 735 LSYWANKQSMLNVTVNGGGNVTE-KLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNS 793
L+ W + L E LD Y +++ L ++ + S+ V + +
Sbjct: 1033 LAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKV 1092
Query: 794 SQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGV 853
++ LH + I+ AP+ FF+ P+G ILNRFS D +D +P T ++ L V
Sbjct: 1093 AKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSA 1152
Query: 854 VSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWT 913
++V V P + L+PL I+ F+++YF SRD+++L+ TT+ P+ SH + +++GL T
Sbjct: 1153 LAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTT 1212
Query: 914 IRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLI--LA 971
IRA++ E R Q+ + D ++ A +RW VR++ I A V+I A S+ L
Sbjct: 1213 IRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLH 1272
Query: 972 KTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRP 1031
+ L AG VGL L+YAL + W VR A++E + +V+R+ E E+ +E P
Sbjct: 1273 RELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAES-YEGLLAP 1331
Query: 1032 ---PPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISAL 1088
P WP +G I N++ Y VLKH+ ALI +K+GI GRTG+GKSS A
Sbjct: 1332 SLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAF 1391
Query: 1089 FRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELW 1147
FR+ + EG I ID I ++ LH LR ++SII Q+PVLF+GT+R NLDP + +D LW
Sbjct: 1392 FRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLW 1451
Query: 1148 NALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANV 1207
AL+ QLK ++ LPG +D + E G NFS GQRQL CLARA +RK I I+DEATA++
Sbjct: 1452 EALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASI 1511
Query: 1208 DPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKES 1267
D T+ ++QK + FA TV+TIAHR++TI+ +D ++VL G + E+D+P LL K+S
Sbjct: 1512 DMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDS 1571
Query: 1268 LFYKMVQ 1274
+F V+
Sbjct: 1572 VFASFVR 1578
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 640 bits (1651), Expect = 0.0
Identities = 433/1317 (32%), Positives = 669/1317 (50%), Gaps = 124/1317 (9%)
Query: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69
P PL +A L S + WL PL + RL+E+ + + D S + L W++EV
Sbjct: 83 PQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVS 142
Query: 70 RAENDAQKPSLTRAIIKCYWKSYLV----LGIFTLIEESAKVIQPIFL-GKIINYFENYD 124
R +K S+ +++ + ++ L+ LGI I A V+ PI + KI+ Y E +
Sbjct: 143 R--RGIEKASVLLVMLR-FQRTRLIFDALLGICFCI---ASVLGPILIIPKILEYSE--E 194
Query: 125 PMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNM 184
+ +V +A L+ C L+ Q +R R A+ + K ++ ++
Sbjct: 195 QLGNVVHGVGLCFALFLSECVKSLSFSSSWIIN--QRTAIRFRAAVSSFAFEKLIQFKSV 252
Query: 185 AMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALL------WMEIGISCL 238
T+G+ ++ + DVN + + GPL I +L+ + IG +
Sbjct: 253 I--HITSGEAISFFTGDVNYLFEGVCY------GPLVLITCASLVICSISSYFIIGYTAF 304
Query: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298
+ +++ PL ++ + T+ +D RIR +EV+T I++IKMY WEK F+ +
Sbjct: 305 IAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKI 364
Query: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
I +LR+KE + + ++ + + F + V + L +TAS F +
Sbjct: 365 IEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASL 424
Query: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418
+RL+V F P A++ ++ + ++ R + F L + + L K +V ++ T
Sbjct: 425 NLLRLSV-FFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVF-EEATLS 482
Query: 419 WDK-----------------ASET------------------PTLQGLSFTVRPGELLAV 443
W + ASE P L ++ V G +L V
Sbjct: 483 WQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGV 542
Query: 444 VGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
G G+GKSSLLSA+L E+ G V V G +AYV QQ W+ SG +R NIL G Y+K R
Sbjct: 543 CGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKAR 602
Query: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
Y +V+ C+L +DL+LL GD+T IG+RG LSGGQK R++LARAVY D IYLLDDPLS
Sbjct: 603 YLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLS 662
Query: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
AVDA V +H+FE CI + L K +LVTHQLQYL+ QI++L++GK+ + GT++E ++
Sbjct: 663 AVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK 722
Query: 624 GIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGAL-ESQDTENV 682
+ L++K ++E+ + T + + ES + S SL A+ E Q T+
Sbjct: 723 KGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALA-TSLEESLNGNAVPEHQLTQ-- 779
Query: 683 PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYW---- 738
EE EG + ++ Y +Y +A ++V + + WWLSYW
Sbjct: 780 -----EEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQG 834
Query: 739 --ANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT 796
N N T+ GN+ + L++Y +Y + + G+ S + V +S
Sbjct: 835 SGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTA 894
Query: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSV 856
LHNK+F + + P+ FFD PIGR+LN F+ D+ LD LLP+ F+ L V+ V+ +
Sbjct: 895 LHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLI 954
Query: 857 AVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRA 916
+ P+I + + +I F + KRLE+ +RSP+FSH+ +SLQGL +I
Sbjct: 955 VSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHV 1014
Query: 917 YKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVA-FGSLILAKTLD 975
Y E F D + LFL+++RW A+RL+ + + + VA F + ++ T
Sbjct: 1015 YGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPY 1074
Query: 976 AGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDL-EKEAPWEYQKRP-PP 1033
+ +V +A++ L L FQ R E E +VER+++Y + EAP + P
Sbjct: 1075 SFKV-MAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQ 1133
Query: 1034 AWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
WP G IIF + + Y P VL + I+ E VGIVGRTG+GKSSL ALFRL E
Sbjct: 1134 GWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVE 1193
Query: 1094 P-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQE 1152
P G+I ID + IGL DLR K+S+IPQ+PVL +GT+R NLDPF+ HTD+++W+AL+
Sbjct: 1194 PMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE- 1252
Query: 1153 VQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTD 1212
R L K I++IDEATA++D TD
Sbjct: 1253 ------------------------------------RTFLTK-AIILIDEATASIDMETD 1275
Query: 1213 ELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLF 1269
LIQ+ IRE F CTVL IAHR+ T+++ D I+V+ +G++ E+D P VL + SLF
Sbjct: 1276 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
Score = 85.9 bits (211), Expect = 2e-16
Identities = 65/238 (27%), Positives = 119/238 (50%), Gaps = 23/238 (9%)
Query: 1058 LKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKM 1117
L + ++ +G+ G TG+GKSSL+SA+ +L +G+ +
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMH---------LLEGSVGVQG---SL 574
Query: 1118 SIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNF 1177
+ +PQ+ + +G +R+N+ + L L +E LP TE+ E G N
Sbjct: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
Query: 1178 SVGQRQLVCLARAILRKNQILIIDEATANVDPRT-----DELIQKKIREKFAHCTVLTIA 1232
S GQ+Q + LARA+ QI ++D+ + VD +E I+K +R K TV+ +
Sbjct: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK----TVVLVT 690
Query: 1233 HRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGK-AEAAALTETAK 1289
H+L + +I++L++G++ E L+Q K+ + +++Q++ K A + L +TAK
Sbjct: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQ-KKGKYAQLIQKMHKEATSDMLQDTAK 747
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 494 bits (1272), Expect = e-139
Identities = 293/725 (40%), Positives = 432/725 (59%), Gaps = 47/725 (6%)
Query: 585 KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLK--------KDNE 636
K ILVTH + YL I+++ GK+ + G+Y E L F L+ +D E
Sbjct: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
Query: 637 ESEQPPVPG----TPTLRN-------------RTFSESSVWSQQSSRPSLKDGALESQDT 679
E+ V G + N R S SS +S SR L+ +
Sbjct: 765 ENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 824
Query: 680 ENVPV-TLSEENRSE-GKVGFQAYKNYFRAGAHWIVF--IFLILLNTAAQVAYVLQDWWL 735
+ L E ++++ G+V Y +Y +A +I F IFL + N + +A ++WL
Sbjct: 825 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALA---SNYWL 881
Query: 736 SYWANKQSMLNVTVNGGGNVTE-KLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSS 794
S W + + VNG T+ +L + LGI G+ V FG + ++ + +L +S
Sbjct: 882 SLWTD-----DPIVNGTQEHTKVRLSVYGALGISQGIAV----FGYSMAVSIGGIL--AS 930
Query: 795 QTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVV 854
+ LH + SIL++P+ FF+R P G ++NRFSK++ +D ++P F+ +L V+G
Sbjct: 931 RCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGAC 990
Query: 855 SVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTI 914
V + P AI + PLG+I+ F++R+++ +SR +KRLES +RSPV+SH + +L G+ I
Sbjct: 991 IVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1050
Query: 915 RAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTL 974
RA++ +ER D D + +A++ + +RW AVRL+ + V+ A ++I +L
Sbjct: 1051 RAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSL 1110
Query: 975 DAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPA 1034
AG VGL++SY+L + W VR S+E+E +++VER+ EY++ EKEAPW+ Q+ PP+
Sbjct: 1111 SAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPS 1170
Query: 1035 -WPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
WP G + F N Y VL+H+ I EKVGIVGRTGAGKSSL LFR++E
Sbjct: 1171 SWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINE 1230
Query: 1094 P-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQE 1152
EG+I ID I +IGLHDLR K++IIPQ+PVLF+G++R NLDPF++++DEE+W +L+
Sbjct: 1231 SAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLEL 1290
Query: 1153 VQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTD 1212
LK+ + LP K+D E AE G N SVGQRQLVCLARA+LRK +IL++DEATA VD TD
Sbjct: 1291 AHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD 1350
Query: 1213 ELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKM 1272
+LIQ IR +F CTVLTIAHRLNTI+D +++VLD G ++EY P LLQ + LFY M
Sbjct: 1351 DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR-GLFYSM 1409
Query: 1273 VQQLG 1277
+ G
Sbjct: 1410 AKDAG 1414
Score = 240 bits (613), Expect = 6e-63
Identities = 150/520 (28%), Positives = 262/520 (50%), Gaps = 54/520 (10%)
Query: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
L W KE + K PSL +
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
Query: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQA 609
Query: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
Query: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRI 475
G L+AVVG VG GKSSLLSA+L E+ G V++ RI
Sbjct: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRI 708
Score = 83.2 bits (204), Expect = 2e-15
Identities = 106/489 (21%), Positives = 204/489 (41%), Gaps = 32/489 (6%)
Query: 166 LRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL-QAIA 224
L V + H I R + +T +G +VN S +++ D + + ++ G L I
Sbjct: 933 LHVDLLHSILRSPMSFFE----RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 988
Query: 225 VTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIR 284
++ + I+ + + +I +Q + L+ + NE + G+
Sbjct: 989 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1048
Query: 285 IIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLG 343
+I+ + ++ F + ++L+ E K S + LA IV V+
Sbjct: 1049 VIRAFEEQERFIHQ-SDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1107
Query: 344 SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA---IVSIRRIQTFLLLDEIS--QR 398
++A V ++V+ L VT + + SE IV++ R++ + ++ + Q
Sbjct: 1108 HSLSAGLVGLSVSY----SLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1163
Query: 399 NRQLPSDGKKMVHVQDFTAFWDKASETP--TLQGLSFTVRPGELLAVVGPVGAGKSSLLS 456
P V +F + + E L+ ++ T+ GE + +VG GAGKSSL
Sbjct: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
Query: 457 AVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
+ + G + + G +I + Q P +FSG+LR N+ +Y E
Sbjct: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283
Query: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
++ LK + L D + G LS GQ+ V LARA+ + I +LD+ +
Sbjct: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343
Query: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
AVD E L + I + + + H+L + +++++L G++ + G ++ L+
Sbjct: 1344 AVDLETD-DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1402
Query: 624 GIDFGSLLK 632
F S+ K
Sbjct: 1403 RGLFYSMAK 1411
Score = 44.7 bits (104), Expect = 6e-04
Identities = 36/121 (29%), Positives = 56/121 (46%), Gaps = 10/121 (8%)
Query: 1008 ISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKS 1067
+S++R+ + E+ P ++RP I N F ++ P L +T I
Sbjct: 611 VSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPE 670
Query: 1068 QEKVGIVGRTGAGKSSLISALF-RLSEPEGKIWI-DKILTTEIGLHDLRKKMSIIPQEPV 1125
V +VG+ G GKSSL+SAL + + EG + I +IL T MS +PQ V
Sbjct: 671 GALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTH--------SMSYLPQVDV 722
Query: 1126 L 1126
+
Sbjct: 723 I 723
>gi|90421313 cystic fibrosis transmembrane conductance regulator
[Homo sapiens]
Length = 1480
Score = 414 bits (1063), Expect = e-115
Identities = 224/652 (34%), Positives = 368/652 (56%), Gaps = 42/652 (6%)
Query: 11 NPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLR 70
+PL+ A++ S++FF W P+ + G+++RLE D+Y + D + +L E+L+ WD+E+
Sbjct: 4 SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELAS 63
Query: 71 AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVA 130
+N P L A+ +C++ ++ GIF + E K +QP+ LG+II +YDP +
Sbjct: 64 KKN----PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRII---ASYDPDNKEE 116
Query: 131 LNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTT 190
+ A L ++ +L H + + GM++R+AM +IY+K L+LS+ + K +
Sbjct: 117 RSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKIS 176
Query: 191 TGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPL 250
GQ+V+LLSN++NKFD+ HF+W PLQ + L+W + S G+ LI+L
Sbjct: 177 IGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALF 236
Query: 251 QSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKI 310
Q+ G++ R + A R+ +E+I I+ +K Y WE++ +I NLR+ E+
Sbjct: 237 QAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLT 296
Query: 311 LRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFP 370
+++ +R N ++FF + +VF++ Y L+ +I ++F ++ +R+ VT FP
Sbjct: 297 RKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILR-KIFTTISFCIVLRMAVTRQFP 355
Query: 371 SAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD--------KA 422
A++ +++ +I +IQ FL E L + M +V TAFW+ KA
Sbjct: 356 WAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENV---TAFWEEGFGELFEKA 412
Query: 423 SE-----------------------TPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVL 459
+ TP L+ ++F + G+LLAV G GAGK+SLL ++
Sbjct: 413 KQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIM 472
Query: 460 GELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQL 519
GEL PS G + GRI++ SQ W+ GT++ NI+FG Y++ RY VIKAC L++D+
Sbjct: 473 GELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISK 532
Query: 520 LEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCIC 579
+ D V+G+ G TLSGGQ+AR++LARAVY+DAD+YLLD P +D + +FE C+C
Sbjct: 533 FAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVC 592
Query: 580 QILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL 631
+++ K ILVT ++++LK A +ILIL +G GT++E DF S L
Sbjct: 593 KLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKL 644
Score = 398 bits (1023), Expect = e-110
Identities = 216/582 (37%), Positives = 339/582 (58%), Gaps = 24/582 (4%)
Query: 711 WIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSG 770
W + IFL + + V ++L + L N N N + + IY G
Sbjct: 865 WCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN---NSYAVIITSTSSYYVFYIYVG 921
Query: 771 LTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIG 830
+ + G R L + + L+ S+ LH+KM S+L+AP+ + G ILNRFSKDI
Sbjct: 922 VADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIA 981
Query: 831 HLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVK 890
LDDLLPLT DFIQ LL V+G ++V + P+I + VP+ + FI LR YFL+TS+ +K
Sbjct: 982 ILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLK 1041
Query: 891 RLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAV 950
+LES RSP+F+HL +SL+GLWT+RA+ + + LF +LH+ WFL+L+T RWF +
Sbjct: 1042 QLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQM 1101
Query: 951 RLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISV 1010
R++ I +F I V F S IL G+VG+ L+ A+ +M QW V S +V+++M SV
Sbjct: 1102 RIEMIFVIFFIAVTFIS-ILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSV 1160
Query: 1011 ERVIEYTDLEKEAPWEYQKRP-------------------PPAWPHEGVIIFDNVNFMYS 1051
RV ++ D+ E +P WP G + ++ Y+
Sbjct: 1161 SRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYT 1220
Query: 1052 PGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLH 1111
GG +L++++ I ++VG++GRTG+GKS+L+SA RL EG+I ID + I L
Sbjct: 1221 EGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQ 1280
Query: 1112 DLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELA 1171
RK +IPQ+ +F+GT RKNLDP+ + +D+E+W EV L+ IE PGK+D L
Sbjct: 1281 QWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLV 1340
Query: 1172 ESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTI 1231
+ G S G +QL+CLAR++L K +IL++DE +A++DP T ++I++ +++ FA CTV+
Sbjct: 1341 DGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILC 1400
Query: 1232 AHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
HR+ +++ + +V++ ++++YD LL N+ SLF + +
Sbjct: 1401 EHRIEAMLECQQFLVIEENKVRQYDSIQKLL-NERSLFRQAI 1441
Score = 90.1 bits (222), Expect = 1e-17
Identities = 114/497 (22%), Positives = 209/497 (42%), Gaps = 62/497 (12%)
Query: 172 HMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHF----LWAGPLQAIAVTA 227
H + L+ + G I+N S D+ D + F L + AIAV A
Sbjct: 950 HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009
Query: 228 LLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIK 287
+L I + A + V++ + L++ F + L+ + + + G+ ++
Sbjct: 1010 VLQPYIFV---ATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLR 1066
Query: 288 MYAWEKSFSNLITN-LRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVI 346
+ + F L L + L S LR +F ++FV F V S++
Sbjct: 1067 AFGRQPYFETLFHKALNLHTANWFLYLSTLR------WFQMRIEMIFVIFFIAVTFISIL 1120
Query: 347 TAS----RVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQ----- 397
T RV + +TL + T+ S+I+ V + S+ R+ F+ + +
Sbjct: 1121 TTGEGEGRVGIILTLAMNIMSTLQWAVNSSID-VDSLMRSVSRVFKFIDMPTEGKPTKST 1179
Query: 398 ---RNRQL-----------------PSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRP 437
+N QL PS G+ + V+D TA + + L+ +SF++ P
Sbjct: 1180 KPYKNGQLSKVMIIENSHVKKDDIWPSGGQ--MTVKDLTAKYTEGGNA-ILENISFSISP 1236
Query: 438 GELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWV 484
G+ + ++G G+GKS+LLSA L L + G + + G + Q+ ++
Sbjct: 1237 GQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFI 1295
Query: 485 FSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVN 544
FSGT R N+ +++ + KV L+ ++ V+ D G LS G K +
Sbjct: 1296 FSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMC 1355
Query: 545 LARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQIL 604
LAR+V A I LLD+P + +D V+ + + Q + IL H+++ + Q L
Sbjct: 1356 LARSVLSKAKILLLDEPSAHLD-PVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFL 1414
Query: 605 ILKDGKMVQKGTYTEFL 621
++++ K+ Q + + L
Sbjct: 1415 VIEENKVRQYDSIQKLL 1431
Score = 73.2 bits (178), Expect = 2e-12
Identities = 110/533 (20%), Positives = 222/533 (41%), Gaps = 76/533 (14%)
Query: 765 LGIYSGLTVATVLFGIARSLLVF-------YVLVNSSQTLHNKMFESILKAPVLFFDRNP 817
+ IY G+ + L I R+LL+ ++ + + + +++ LK D+
Sbjct: 119 IAIYLGIGLC--LLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKIS 176
Query: 818 IGRILNRFSKDIGHLDDLLPLTFLDFIQTL--LQVVGVVSVAVAVIPWIAIP-LVPLGII 874
IG++++ S ++ D+ L L +I L ++G++ + + + L+ L +
Sbjct: 177 IGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALF 236
Query: 875 FIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLH 934
L R ++ RD + + + R + S + ++Q +++AY EE +++ + +
Sbjct: 237 QAGLGRMMMKY-RDQRAGKISERLVITSEMIENIQ---SVKAYCWEEAMEKMIENLRQTE 292
Query: 935 SE-----AWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTL 989
+ A+ + +S +F FV+ ++ L K + ++ +S+ + L
Sbjct: 293 LKLTRKAAYVRYFNSSAFF------FSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVL 346
Query: 990 M----GMFQWCVR---QSAEVENMMISVERVIEYTDLEKE-APWEYQKRPPPAWPHEGV- 1040
F W V+ S N + + EY LE E A+ EG
Sbjct: 347 RMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFG 406
Query: 1041 ---------------------IIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGA 1079
+ F N + + +P VLK + I+ + + + G TGA
Sbjct: 407 ELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTP----VLKDINFKIERGQLLAVAGSTGA 462
Query: 1080 GKSSLISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPF 1138
GK+SL+ + EP EGKI H R +S Q + GT+++N+
Sbjct: 463 GKTSLLMVIMGELEPSEGKI-----------KHSGR--ISFCSQFSWIMPGTIKENIIFG 509
Query: 1139 NEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQIL 1198
+ + + ++ QL+E I K + L E G S GQR + LARA+ + +
Sbjct: 510 VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLY 569
Query: 1199 IIDEATANVDPRTD-ELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSG 1250
++D +D T+ E+ + + + A+ T + + ++ + +DKI++L G
Sbjct: 570 LLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEG 622
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 236 bits (602), Expect = 1e-61
Identities = 295/1309 (22%), Positives = 562/1309 (42%), Gaps = 164/1309 (12%)
Query: 70 RAENDAQKPSLTRAIIKCY----W--KSYLVLGIFTLIEESAKV-IQPIFLGKIINYFEN 122
++E D ++ T ++ + W K Y+V+G I A + + + G++ + F N
Sbjct: 22 KSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFAN 81
Query: 123 YDPMDSVALN--------------------TAYAYATVLTFCTLILAILHHLYFYHVQCA 162
++ + N T YAY +++A + F+ +
Sbjct: 82 AGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAG 141
Query: 163 GM--RLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKF-----DQVTVFLHFL 215
++R H I R+ + ++ G++ L++DV+K D++ +F +
Sbjct: 142 RQIHKIRKQFFHAIMRQEIGWFDVH----DVGELNTRLTDDVSKINEGIGDKIGMFFQSM 197
Query: 216 WAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARI-- 273
A + + G + +++L + G + ++FTD +
Sbjct: 198 -----------ATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLA 246
Query: 274 -----RTMNEVITGIRIIKMYAWEKS----FSNLITNLRKKEISKILRSSCLRGMNLASF 324
EV+ IR + + +K ++ + ++ I K + ++ G
Sbjct: 247 YAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLI 306
Query: 325 FSASKIIVFVTFTTYVLLG--SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVS 382
+ AS + F TT VL G S+ VF +V L GA + A A
Sbjct: 307 Y-ASYALAFWYGTTLVLSGEYSIGQVLTVFFSV-LIGAFSVGQASPSIEAFANARGAAYE 364
Query: 383 IRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLA 442
I +I + ++ P + K + ++ + E L+GL+ V+ G+ +A
Sbjct: 365 IFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVA 424
Query: 443 VVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-------------IAYVSQQPWVFSGTL 489
+VG G GKS+ + + P+ G+VSV G+ I VSQ+P +F+ T+
Sbjct: 425 LVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTI 484
Query: 490 RSNILFGKK-YEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARA 548
NI +G++ + EK +K + L T++G+RG LSGGQK R+ +ARA
Sbjct: 485 AENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARA 544
Query: 549 VYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKD 608
+ ++ I LLD+ SA+D E S + ++ + + + TI++ H+L ++ A I D
Sbjct: 545 LVRNPKILLLDEATSALDTE-SEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDD 603
Query: 609 GKMVQKGTYTEFLKS-GIDF--------GSLLKKDNEESEQPPVPGTPTLRNRTFSESSV 659
G +V+KG + E +K GI F G+ ++ +N E + + S SS+
Sbjct: 604 GVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSND-SRSSL 662
Query: 660 WSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGF-QAYKNYFRAGAHWIVFIFLI 718
++S+R S++ SQ + T + S V F + K +++V +F
Sbjct: 663 IRKRSTRRSVRG----SQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCA 718
Query: 719 LLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWY------LGIYSGLT 772
++N Q A+ + ++ V T++ + N + LGI S +T
Sbjct: 719 IINGGLQPAFAIIF---------SKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFIT 769
Query: 773 --VATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFD--RNPIGRILNRFSKD 828
+ FG A +L ++ L +F S+L+ V +FD +N G + R + D
Sbjct: 770 FFLQGFTFGKAGEIL--------TKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAND 821
Query: 829 IGHLDDLLPLTFLDFIQTLLQV-VGVVS----------VAVAVIPWIAIPLVPLGIIFIF 877
+ + Q + + G++ + +A++P IAI V +
Sbjct: 822 AAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGV------VE 875
Query: 878 LRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEA 937
++ + +D K LE + + + +++ T+ + E++ + ++ +
Sbjct: 876 MKMLSGQALKDKKELEGSGKIA-----TEAIENFRTVVSLTQEQKFEHMYAQSLQV---P 927
Query: 938 WFLFLTTSRWFAVRLDAICAMFVIIVA----FGSLILAKTL----DAGQVGLALSYALTL 989
+ L + F + AM A FG+ ++A L D V A+ +
Sbjct: 928 YRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMA 987
Query: 990 MGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFM 1049
+G A+ + + +IE T L Y EG + F V F
Sbjct: 988 VGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS----YSTEGLMPNTLEGNVTFGEVVFN 1043
Query: 1050 YSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTTE 1107
Y + VL+ L+ +K + + +VG +G GKS+++ L R +P GK+ +D
Sbjct: 1044 YPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKR 1103
Query: 1108 IGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNEHTDEELWNALQEVQLKETIEDLPG 1164
+ + LR + I+ QEP+LF ++ +N+ D + EE+ A +E + IE LP
Sbjct: 1104 LNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPN 1163
Query: 1165 KMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFA 1224
K T++ + G+ S GQ+Q + +ARA++R+ IL++DEAT+ +D +++++Q+ + +
Sbjct: 1164 KYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKARE 1223
Query: 1225 HCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
T + IAHRL+TI ++D I+V +GR+KE+ LL K +++ MV
Sbjct: 1224 GRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK-GIYFSMV 1271
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 210 bits (535), Expect = 6e-54
Identities = 226/954 (23%), Positives = 434/954 (45%), Gaps = 132/954 (13%)
Query: 392 LDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
+D S+R + P K + D + + L+GL+ V+ G+ +A+VG G GK
Sbjct: 377 IDSFSERGHK-PDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGK 435
Query: 452 SSLLSAVLGELAPSHGLVSVHGR-------------IAYVSQQPWVFSGTLRSNILFGK- 497
S+ + + P G +++ G+ I VSQ+P +FS T+ NI +G+
Sbjct: 436 STTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRG 495
Query: 498 KYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYL 557
+ +K +K + + L T++G+RG LSGGQK R+ +ARA+ ++ I L
Sbjct: 496 NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILL 555
Query: 558 LDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTY 617
LD+ SA+D E S + + + + TI++ H+L ++ A I +DG +V++G++
Sbjct: 556 LDEATSALDTE-SEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSH 614
Query: 618 TEFL-KSGIDF--------GSLLKKDNEE--SEQPPVPGTPT-LRNRTFSESSVWSQQSS 665
+E + K G+ F GS ++ + E E+ P ++R F S+ + ++S
Sbjct: 615 SELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNS 674
Query: 666 RPSLKDGALESQDTE-NVP----VTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL 720
+ K +E+ E NVP + + + N++E +++V +
Sbjct: 675 QMCQKSLDVETDGLEANVPPVSFLKVLKLNKTE--------------WPYFVVGTVCAIA 720
Query: 721 NTAAQVAY------VLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLT-- 772
N Q A+ ++ + A KQ N+ + +LGI S T
Sbjct: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSL----------IFLFLGIISFFTFF 770
Query: 773 VATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFD--RNPIGRILNRFSKDIG 830
+ FG A +L ++ L + F+++L+ + +FD +N G + R + D
Sbjct: 771 LQGFTFGKAGEIL--------TRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA 822
Query: 831 HLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPW----IAIPLVPLGIIFIFLRRYFL--E 884
+ T L I + +G + + W + + +VP+ + + L
Sbjct: 823 QVQGATG-TRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGN 881
Query: 885 TSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEER-----CQELFDAHQDLHSEAWF 939
RD K LE+ + + +++ + T+ + E + ++L+ +++ +A
Sbjct: 882 AKRDKKELEAAGKI-----ATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHI 936
Query: 940 LFLT--TSRWFAVRLDAICAMF-------------VIIVAFGSLILAKTLDAGQVGLALS 984
+T S+ F A C F +I+ F +++ A
Sbjct: 937 YGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPD 996
Query: 985 YALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFD 1044
YA + SA M+ + +I+ E P +++ G I F+
Sbjct: 997 YAK---------AKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE----------GNITFN 1037
Query: 1045 NVNFMYSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDK 1102
V F Y + VL+ L+ +K + + +VG +G GKS+++ L R +P G + +D
Sbjct: 1038 EVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG 1097
Query: 1103 ILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNEHTDEELWNALQEVQLKETI 1159
++ + LR ++ I+ QEP+LF ++ +N+ D + +E+ +A + + I
Sbjct: 1098 QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFI 1157
Query: 1160 EDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKI 1219
E LP K +T + + G+ S GQ+Q + +ARA++R+ QIL++DEAT+ +D +++++Q+ +
Sbjct: 1158 ETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEAL 1217
Query: 1220 REKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
+ T + IAHRL+TI ++D I+V +GR+KE+ LL K +++ MV
Sbjct: 1218 DKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK-GIYFSMV 1270
Score = 129 bits (324), Expect = 2e-29
Identities = 129/542 (23%), Positives = 250/542 (46%), Gaps = 40/542 (7%)
Query: 753 GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT--LHNKMFESILKAPV 810
G + E+ ++ Y YSGL ++ + + F+ L Q + K F +IL+ +
Sbjct: 106 GKILEE-EMTRYAYYYSGLGAGVLVAAYIQ--VSFWTLAAGRQIRKIRQKFFHAILRQEI 162
Query: 811 LFFDRNPIGRILNRFSKDIGHLDD-----------LLPLTFLDFIQTLLQVVGVVSVAVA 859
+FD N + R + DI + + + F FI ++ + V +A
Sbjct: 163 GWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMA 222
Query: 860 VIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKA 919
+ P + + I ++ K L + ++ + +L + T+ A+
Sbjct: 223 ISPILGLSAAVWAKIL---------SAFSDKELAAYAKAGAVAE--EALGAIRTVIAFGG 271
Query: 920 EERCQELFDAHQDLHSEAWFL-FLTTSRWFAVRLDAICAMFVIIVAFGS-LILAKTLDAG 977
+ + E + H + E ++ + + I A + + +GS L+++K G
Sbjct: 272 QNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIG 331
Query: 978 Q---VGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPA 1034
V ++ +G C+ A + +I+ + + ++ E +P
Sbjct: 332 NAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIID-NNPKIDSFSERGHKPDSI 390
Query: 1035 WPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
+G + F++V+F Y S +LK L ++S + V +VG +G GKS+ + + RL +
Sbjct: 391 ---KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYD 447
Query: 1094 P-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEH-TDEELWNALQ 1151
P EG I ID ++ LR+ + ++ QEPVLF+ T+ +N+ + T +E+ A++
Sbjct: 448 PDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVK 507
Query: 1152 EVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRT 1211
E E I LP K DT + E G+ S GQ+Q + +ARA++R +IL++DEAT+ +D +
Sbjct: 508 EANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 567
Query: 1212 DELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYK 1271
+ +Q + + T + IAHRL+T+ ++D I + G + E + L KE +++K
Sbjct: 568 EAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGS-HSELMKKEGVYFK 626
Query: 1272 MV 1273
+V
Sbjct: 627 LV 628
Score = 113 bits (283), Expect = 1e-24
Identities = 137/575 (23%), Positives = 246/575 (42%), Gaps = 56/575 (9%)
Query: 92 YLVLGIFTLIEESAKVIQPIF---LGKIINYFENYDPMDSVALNTAYAYATVLTFCTLIL 148
Y V+G I +QP F +II F D D+V ++ + F +I
Sbjct: 710 YFVVGTVCAIANGG--LQPAFSVIFSEIIAIFGPGD--DAVKQQKCNIFSLIFLFLGIIS 765
Query: 149 AILHHLYFYHVQCAGMRLRVAMCHMIYRKALR--LSNMAMGKTTTGQIVNLLSNDVNKFD 206
L + AG L + M ++ LR +S K +TG + L+ D +
Sbjct: 766 FFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQ 825
Query: 207 QVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILL---PLQSCFG----KLFS 259
T L A + A L I IS + G + ++LL P+ + G KL +
Sbjct: 826 GATGTRLALIAQNI------ANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLA 879
Query: 260 SLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGM 319
+ +A + E I IR + E+ F ++ +++ R+S +
Sbjct: 880 GNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYV----EKLYGPYRNSVQKAH 935
Query: 320 NLASFFSASKIIVFVTFTTYVLLGSVITASR---------VFVAVTLYGAVRLT-VTLFF 369
FS S+ ++ ++ G+ + + VF A+ ++GAV L + F
Sbjct: 936 IYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI-VFGAVALGHASSFA 994
Query: 370 PSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQ 429
P + A + L+D S+ + P + + + + + P LQ
Sbjct: 995 PDYAKAKLSAAHLFMLFERQPLIDSYSEEGLK-PDKFEGNITFNEVVFNYPTRANVPVLQ 1053
Query: 430 GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-------------IA 476
GLS V+ G+ LA+VG G GKS+++ + P G V + G+ +
Sbjct: 1054 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLG 1113
Query: 477 YVSQQPWVFSGTLRSNILFGKKYEKERYEKVI---KACALKKDLQLLEDGDLTVIGDRGT 533
VSQ+P +F ++ NI +G ++++ KA + ++ L T +GD+GT
Sbjct: 1114 IVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGT 1173
Query: 534 TLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQ 593
LSGGQK R+ +ARA+ + I LLD+ SA+D E S + + + + + I++ H+
Sbjct: 1174 QLSGGQKQRIAIARALIRQPQILLLDEATSALDTE-SEKVVQEALDKAREGRTCIVIAHR 1232
Query: 594 LQYLKAASQILILKDGKMVQKGTYTEFL-KSGIDF 627
L ++ A I++ ++G++ + GT+ + L + GI F
Sbjct: 1233 LSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYF 1267
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 206 bits (525), Expect = 9e-53
Identities = 227/961 (23%), Positives = 438/961 (45%), Gaps = 139/961 (14%)
Query: 392 LDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
+D S+R + P K + D + + L+GL+ V+ G+ +A+VG G GK
Sbjct: 377 IDSFSERGHK-PDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGK 435
Query: 452 SSLLSAVLGELAPSHGLVSVHGR-------------IAYVSQQPWVFSGTLRSNILFGK- 497
S+ + + P G +++ G+ I VSQ+P +FS T+ NI +G+
Sbjct: 436 STTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRG 495
Query: 498 KYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYL 557
+ +K +K + + L T++G+RG LSGGQK R+ +ARA+ ++ I L
Sbjct: 496 NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILL 555
Query: 558 LDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTY 617
LD+ SA+D E S + + + + TI++ H+L ++ A I +DG +V++G++
Sbjct: 556 LDEATSALDTE-SEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSH 614
Query: 618 TEFL-KSGIDF--------GSLLKKDNEE--SEQPPVPGTPT-LRNRTFSESSVWSQQSS 665
+E + K G+ F GS ++ + E E+ P ++R F S+ + ++S
Sbjct: 615 SELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNS 674
Query: 666 RPSLKDGALESQDTE-NVP----VTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL 720
+ K +E+ E NVP + + + N++E +++V +
Sbjct: 675 QMCQKSLDVETDGLEANVPPVSFLKVLKLNKTE--------------WPYFVVGTVCAIA 720
Query: 721 NTAAQVAY------VLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLT-- 772
N Q A+ ++ + A KQ N+ + +LGI S T
Sbjct: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSL----------IFLFLGIISFFTFF 770
Query: 773 VATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFD--RNPIGRILNRFSKDIG 830
+ FG A +L ++ L + F+++L+ + +FD +N G + R + D
Sbjct: 771 LQGFTFGKAGEIL--------TRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA 822
Query: 831 HLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPW----IAIPLVPLGIIFIFLRRYFL--E 884
+ T L I + +G + + W + + +VP+ + + L
Sbjct: 823 QVQGATG-TRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGN 881
Query: 885 TSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEER-----CQELFDAHQDLHSEAWF 939
RD K LE+ + + +++ + T+ + E + ++L+ +++ +A
Sbjct: 882 AKRDKKELEAAGKI-----ATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHI 936
Query: 940 LFLT--TSRWFAVRLDAICAMF-------------VIIVAFGSLILAKTLDAGQVGLALS 984
+T S+ F A C F +I+ F +++ A
Sbjct: 937 YGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPD 996
Query: 985 YALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFD 1044
YA + SA M+ + +I+ E P +++ G I F+
Sbjct: 997 YAK---------AKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE----------GNITFN 1037
Query: 1045 NVNFMYSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWID- 1101
V F Y + VL+ L+ +K + + +VG +G GKS+++ L R +P G +++D
Sbjct: 1038 EVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDF 1097
Query: 1102 --KIL----TTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNEHTDEELWNALQE 1152
++L ++ + LR ++ I+ QEP+LF ++ +N+ D + +E+ +A +
Sbjct: 1098 GFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1157
Query: 1153 VQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTD 1212
+ IE LP K +T + + G+ S GQ+Q + +ARA++R+ QIL++DEAT+ +D ++
Sbjct: 1158 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1217
Query: 1213 ELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKM 1272
+++Q+ + + T + IAHRL+TI ++D I+V +GR+KE+ LL K +++ M
Sbjct: 1218 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK-GIYFSM 1276
Query: 1273 V 1273
V
Sbjct: 1277 V 1277
Score = 129 bits (324), Expect = 2e-29
Identities = 129/542 (23%), Positives = 250/542 (46%), Gaps = 40/542 (7%)
Query: 753 GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT--LHNKMFESILKAPV 810
G + E+ ++ Y YSGL ++ + + F+ L Q + K F +IL+ +
Sbjct: 106 GKILEE-EMTRYAYYYSGLGAGVLVAAYIQ--VSFWTLAAGRQIRKIRQKFFHAILRQEI 162
Query: 811 LFFDRNPIGRILNRFSKDIGHLDD-----------LLPLTFLDFIQTLLQVVGVVSVAVA 859
+FD N + R + DI + + + F FI ++ + V +A
Sbjct: 163 GWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMA 222
Query: 860 VIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKA 919
+ P + + I ++ K L + ++ + +L + T+ A+
Sbjct: 223 ISPILGLSAAVWAKIL---------SAFSDKELAAYAKAGAVAE--EALGAIRTVIAFGG 271
Query: 920 EERCQELFDAHQDLHSEAWFL-FLTTSRWFAVRLDAICAMFVIIVAFGS-LILAKTLDAG 977
+ + E + H + E ++ + + I A + + +GS L+++K G
Sbjct: 272 QNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIG 331
Query: 978 Q---VGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPA 1034
V ++ +G C+ A + +I+ + + ++ E +P
Sbjct: 332 NAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIID-NNPKIDSFSERGHKPDSI 390
Query: 1035 WPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
+G + F++V+F Y S +LK L ++S + V +VG +G GKS+ + + RL +
Sbjct: 391 ---KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYD 447
Query: 1094 P-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEH-TDEELWNALQ 1151
P EG I ID ++ LR+ + ++ QEPVLF+ T+ +N+ + T +E+ A++
Sbjct: 448 PDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVK 507
Query: 1152 EVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRT 1211
E E I LP K DT + E G+ S GQ+Q + +ARA++R +IL++DEAT+ +D +
Sbjct: 508 EANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 567
Query: 1212 DELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYK 1271
+ +Q + + T + IAHRL+T+ ++D I + G + E + L KE +++K
Sbjct: 568 EAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGS-HSELMKKEGVYFK 626
Query: 1272 MV 1273
+V
Sbjct: 627 LV 628
Score = 110 bits (274), Expect = 1e-23
Identities = 137/582 (23%), Positives = 245/582 (42%), Gaps = 63/582 (10%)
Query: 92 YLVLGIFTLIEESAKVIQPIF---LGKIINYFENYDPMDSVALNTAYAYATVLTFCTLIL 148
Y V+G I +QP F +II F D D+V ++ + F +I
Sbjct: 710 YFVVGTVCAIANGG--LQPAFSVIFSEIIAIFGPGD--DAVKQQKCNIFSLIFLFLGIIS 765
Query: 149 AILHHLYFYHVQCAGMRLRVAMCHMIYRKALR--LSNMAMGKTTTGQIVNLLSNDVNKFD 206
L + AG L + M ++ LR +S K +TG + L+ D +
Sbjct: 766 FFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQ 825
Query: 207 QVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILL---PLQSCFG----KLFS 259
T L A + A L I IS + G + ++LL P+ + G KL +
Sbjct: 826 GATGTRLALIAQNI------ANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLA 879
Query: 260 SLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGM 319
+ +A + E I IR + E+ F ++ +++ R+S +
Sbjct: 880 GNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYV----EKLYGPYRNSVQKAH 935
Query: 320 NLASFFSASKIIVFVTFTTYVLLGSVITASR---------VFVAVTLYGAVRLT-VTLFF 369
FS S+ ++ ++ G+ + + VF A+ ++GAV L + F
Sbjct: 936 IYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI-VFGAVALGHASSFA 994
Query: 370 PSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQ 429
P + A + L+D S+ + P + + + + + P LQ
Sbjct: 995 PDYAKAKLSAAHLFMLFERQPLIDSYSEEGLK-PDKFEGNITFNEVVFNYPTRANVPVLQ 1053
Query: 430 GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSV------------------ 471
GLS V+ G+ LA+VG G GKS+++ + P G V V
Sbjct: 1054 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQ 1113
Query: 472 --HGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVI---KACALKKDLQLLEDGDLT 526
++ VSQ+P +F ++ NI +G ++++ KA + ++ L T
Sbjct: 1114 WLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYET 1173
Query: 527 VIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKI 586
+GD+GT LSGGQK R+ +ARA+ + I LLD+ SA+D E S + + + + +
Sbjct: 1174 RVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTE-SEKVVQEALDKAREGRT 1232
Query: 587 TILVTHQLQYLKAASQILILKDGKMVQKGTYTEFL-KSGIDF 627
I++ H+L ++ A I++ ++G++ + GT+ + L + GI F
Sbjct: 1233 CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYF 1274
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 184 bits (466), Expect = 6e-46
Identities = 102/334 (30%), Positives = 178/334 (53%), Gaps = 30/334 (8%)
Query: 6 QEVKPNPLQD--ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGF 63
+ V PNP + A SR+FFWW + G++ LEE D++S+ EDRSQ + ++L
Sbjct: 200 KNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEA 259
Query: 64 WDKE-----------------------VLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTL 100
W K+ +L A +KPS +A++ + S+L+ F L
Sbjct: 260 WRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKL 319
Query: 101 IEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
I++ I P L +I + N PM + A ++ C+++ +++ Y++++
Sbjct: 320 IQDLLSFINPQLLSILIRFISN--PM--APSWWGFLVAGLMFLCSMMQSLILQHYYHYIF 375
Query: 161 CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL 220
G++ R + +IYRKAL ++N +T G+IVNL+S D +F + FL+ LW+ PL
Sbjct: 376 VTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPL 435
Query: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
Q I LW +G S LAG+A +++L+PL + + K D+RI+ M+E++
Sbjct: 436 QIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEIL 495
Query: 281 TGIRIIKMYAWEKSFSNLITNLRKKEISKILRSS 314
GI+++K+YAWE SF + +R+ E+ ++LR++
Sbjct: 496 NGIKVLKLYAWEPSFLKQVEGIRQGEL-QLLRTA 528
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 152 bits (385), Expect = 2e-36
Identities = 100/327 (30%), Positives = 174/327 (53%), Gaps = 9/327 (2%)
Query: 948 FAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMM 1007
F+V L AI + + G+L + + + LS L +G RQ+ +
Sbjct: 386 FSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQA------L 439
Query: 1008 ISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKS 1067
I + + ++ + + P P + FDNV+F Y G VL ++ + +
Sbjct: 440 IDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQK-VLSGISFEVPA 498
Query: 1068 QEKVGIVGRTGAGKSSLISALFRLSEPE-GKIWIDKILTTEIGLHDLRKKMSIIPQEPVL 1126
+KV IVG +G+GKS+++ LFR EP+ G I++ ++ L LR+ + ++PQ+ VL
Sbjct: 499 GKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVL 558
Query: 1127 FTGTMRKNLDPFN-EHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLV 1185
F T+ NL N + EE++ + L + I +P DT++ E G S G++Q V
Sbjct: 559 FHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRV 618
Query: 1186 CLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIM 1245
+ARAIL+ +++ DEAT+++D T+E I +++ H T + IAHRL+T++D+D+I+
Sbjct: 619 AIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEII 678
Query: 1246 VLDSGRLKEYDEPYVLLQNKESLFYKM 1272
VLD G++ E + LL N S++ +M
Sbjct: 679 VLDQGKVAERGTHHGLLANPHSIYSEM 705
Score = 99.0 bits (245), Expect = 3e-20
Identities = 80/335 (23%), Positives = 156/335 (46%), Gaps = 23/335 (6%)
Query: 302 LRKKEISKILRSSCLRGMNL--ASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYG 359
L+ E + + +S L +N ++ FS + V + ++ G++ V V L+
Sbjct: 361 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLF- 419
Query: 360 AVRLTVTLFFPSAIERVS-EAIVSIRRIQTFLLLD-EISQRNRQLPSDGKKMVHVQDF-T 416
+L++ L F + R + +A++ + + T L +D +I + P F
Sbjct: 420 --QLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDN 477
Query: 417 AFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-- 474
++ L G+SF V G+ +A+VG G+GKS+++ + P G + + G+
Sbjct: 478 VHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNI 537
Query: 475 -----------IAYVSQQPWVFSGTLRSNILFGK-KYEKERYEKVIKACALKKDLQLLED 522
+ V Q +F T+ N+L+G E V K L + +
Sbjct: 538 QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPH 597
Query: 523 GDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQIL 582
G T +G+RG LSGG+K RV +ARA+ +D + L D+ S++D+ ++ + ++
Sbjct: 598 GYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDS-ITEETILGAMKDVV 656
Query: 583 HEKITILVTHQLQYLKAASQILILKDGKMVQKGTY 617
+ +I + H+L + A +I++L GK+ ++GT+
Sbjct: 657 KHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTH 691
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 151 bits (382), Expect = 4e-36
Identities = 140/537 (26%), Positives = 244/537 (45%), Gaps = 59/537 (10%)
Query: 774 ATVLFGIARSLLVFYVLVNSSQTLHNKM----FESILKAPVLFFDRNPIGRILNRFSKDI 829
A L G A + + Y++ S Q + N++ F SIL+ V FFD+ G ++NR S D
Sbjct: 220 AVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDT 279
Query: 830 GHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLV----PLGIIFIFLRRYFLET 885
L + D ++ Q +S+ V P +A ++ P+ II + RY
Sbjct: 280 ALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYL--- 336
Query: 886 SRDVKRLESTTRSPVFSHLSSSLQGLWTIRAY-----KAEERCQELFDAHQDLHSEAWFL 940
R + ++ + + + + T+RA+ + E+ ++ Q EA
Sbjct: 337 -RKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEA--- 392
Query: 941 FLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQS 1000
F + A L + ++ G L+ + + G++ L YA W
Sbjct: 393 FARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAF-------WVGISI 445
Query: 1001 AEVENMMISVERVIEYTDLEKEAP-----WEYQKRPPPAWPHEGVII----------FDN 1045
+ + Y++L K WE +R P +EGVI+ F N
Sbjct: 446 GGLSSF---------YSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKN 496
Query: 1046 VNFMYSPGGPLV--LKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDK 1102
V+F Y P P V + + I S +VG +G+GKS+++S L RL +P G I +D
Sbjct: 497 VHFAY-PARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDG 555
Query: 1103 ILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL----DPFNEHTDEELWNALQEVQLKET 1158
++ LR K+ + QEP+LF+ ++ +N+ D + T EE+ +
Sbjct: 556 HDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAF 615
Query: 1159 IEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKK 1218
I + P +T + E G S GQ+Q + +ARA+L+ +IL++DEAT+ +D + L+Q+
Sbjct: 616 IRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEA 675
Query: 1219 IREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQ 1275
+ TVL IAHRL+TI +++ + VLD G++ EY + LL ++ K++ +
Sbjct: 676 LDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNK 732
Score = 134 bits (337), Expect = 6e-31
Identities = 134/560 (23%), Positives = 249/560 (44%), Gaps = 77/560 (13%)
Query: 110 PIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLIL-------AILHHLYFYHVQCA 162
P FLGKII D + N Y+ LT L L A + + Y +Q +
Sbjct: 189 PFFLGKII---------DVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTS 239
Query: 163 GMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQ-VTVFLHF-LWAGPL 220
G R+ + ++ LR KT TG+++N LS+D + VT L L AG
Sbjct: 240 GQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQ 299
Query: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
++ ++ + ++ ++ ++V+ + + +G+ L T + E I
Sbjct: 300 ASVGISMMFFVSPNLATFV-LSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERI 358
Query: 281 TGIRIIKMYAWEKSFSNLITNLRK--KEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
+R ++ + E +T + K ++ +++ + A FF A+
Sbjct: 359 GNVRTVRAFGKE------MTEIEKYASKVDHVMQLARKEAFARAGFFGATG--------- 403
Query: 339 YVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLL------- 391
L G++I S ++ L G+ +TV S + +SI + +F
Sbjct: 404 --LSGNLIVLSVLYKGGLLMGSAHMTVGEL-SSFLMYAFWVGISIGGLSSFYSELMKGLG 460
Query: 392 ----LDEISQRNRQLPSDGKKMVHVQDFTAF---------WDKASETPTLQGLSFTVRPG 438
L E+ +R +LP + +++ + F + E P Q S ++ G
Sbjct: 461 AGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSG 520
Query: 439 ELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWVF 485
+ A+VGP G+GKS++LS +L P+ G +S+ G +I VSQ+P +F
Sbjct: 521 SVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILF 580
Query: 486 SGTLRSNILFG----KKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKA 541
S ++ NI +G E ++V + ++ G TV+G++G LSGGQK
Sbjct: 581 SCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQ 640
Query: 542 RVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAAS 601
R+ +ARA+ ++ I LLD+ SA+DAE + +L + + +++ + +++ H+L +K A+
Sbjct: 641 RIAIARALLKNPKILLLDEATSALDAE-NEYLVQEALDRLMDGRTVLVIAHRLSTIKNAN 699
Query: 602 QILILKDGKMVQKGTYTEFL 621
+ +L GK+ + G + E L
Sbjct: 700 MVAVLDQGKITEYGKHEELL 719
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 148 bits (373), Expect = 4e-35
Identities = 147/587 (25%), Positives = 260/587 (44%), Gaps = 65/587 (11%)
Query: 738 WANKQSMLNVTVNGG--GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQ 795
W N N+T NG G + + ++ + Y+G+ VA ++ G + Q
Sbjct: 114 WTNSSLNQNMT-NGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQ 172
Query: 796 TLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVV---- 851
+ F I++ + +FD N +G + RFS DI ++D + FIQ + +
Sbjct: 173 KMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFL 232
Query: 852 -------GVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHL 904
+ V ++V P I I +G+ Y L+ V +
Sbjct: 233 LGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKA--------GVVADEV 284
Query: 905 SSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFL-------FLTTSRWFAVRLDAICA 957
SS++ T+ A+ E+R E ++ + + ++ W + F T W + L
Sbjct: 285 ISSMR---TVAAFGGEKREVERYEKNL-VFAQRWGIRKGIVMGFFTGFVWCLIFL----- 335
Query: 958 MFVIIVAFGSLILAKTLDAG--------QVGLALSYALTLMGMFQWCVRQSAEVENMMIS 1009
+ + +GS ++ LD G Q+ L++ +G C+ A S
Sbjct: 336 CYALAFWYGSTLV---LDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATS 392
Query: 1010 VERVIE---YTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLV--LKHLTAL 1064
+ I+ D E ++ + +G I F NV F Y P P V L L +
Sbjct: 393 IFETIDRKPIIDCMSEDGYKLDRI-------KGEIEFHNVTFHY-PSRPEVKILNDLNMV 444
Query: 1065 IKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQE 1123
IK E +VG +GAGKS+ + + R +P EG + +D + + LR ++ I+ QE
Sbjct: 445 IKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQE 504
Query: 1124 PVLFTGTMRKNLDPFNEH-TDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQR 1182
PVLF+ T+ +N+ E T E++ A +E I DLP + DT + E G S GQ+
Sbjct: 505 PVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQK 564
Query: 1183 QLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSD 1242
Q V +ARA++R +IL++D AT+ +D ++ ++Q+ + + T++++AHRL+T+ +D
Sbjct: 565 QRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAAD 624
Query: 1243 KIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAK 1289
I+ + G E LL+ K +++ +V + A E K
Sbjct: 625 TIIGFEHGTAVERGTHEELLERK-GVYFTLVTLQSQGNQALNEEDIK 670
Score = 121 bits (304), Expect = 4e-27
Identities = 133/541 (24%), Positives = 241/541 (44%), Gaps = 68/541 (12%)
Query: 175 YRKALRLSNMAMGKTTTGQIVNLLSNDVNKF-----DQVTVFLHFLWAGPLQAIAVTALL 229
+R+ +R+ + G++ S+D+NK DQ+ +F+ Q + T
Sbjct: 179 FRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFI--------QRMTSTICG 230
Query: 230 WMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM-------NEVITG 282
++ + G + ++++ + G +++ + FTD ++ +EVI+
Sbjct: 231 FL---LGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISS 287
Query: 283 IRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLL 342
+R + + EK +K + R +G+ + F ++F+ +
Sbjct: 288 MRTVAAFGGEKRE----VERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWY 343
Query: 343 GSVI----------TASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSI-RRIQTFLL 391
GS + T ++F++V + GA+ L A A SI I +
Sbjct: 344 GSTLVLDEGEYTPGTLVQIFLSV-IVGALNLGNASPCLEAFATGRAAATSIFETIDRKPI 402
Query: 392 LDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
+D +S+ +L K + + T + E L L+ ++PGE+ A+VGP GAGK
Sbjct: 403 IDCMSEDGYKLDRI-KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGK 461
Query: 452 SSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKK 498
S+ L + P G+V+V G +I V Q+P +FS T+ NI +G+
Sbjct: 462 STALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGR- 520
Query: 499 YEKERYEKVIKAC----ALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDAD 554
E E +++A A + L + D T++G+ G +SGGQK RV +ARA+ ++
Sbjct: 521 -EDATMEDIVQAAKEANAYNFIMDLPQQFD-TLVGEGGGQMSGGQKQRVAIARALIRNPK 578
Query: 555 IYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQK 614
I LLD SA+D E S + + + +I H I V H+L ++AA I+ + G V++
Sbjct: 579 ILLLDMATSALDNE-SEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVER 637
Query: 615 GTYTEFL-KSGIDFG--SLLKKDNEESEQPPVPGT--PTLRNRTFSESSVWSQQSSRPSL 669
GT+ E L + G+ F +L + N+ + + + RTFS S Q S R S+
Sbjct: 638 GTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSY--QDSLRASI 695
Query: 670 K 670
+
Sbjct: 696 R 696
Score = 120 bits (300), Expect = 1e-26
Identities = 84/262 (32%), Positives = 139/262 (53%), Gaps = 9/262 (3%)
Query: 1019 LEKEAPWEYQKRPPPAWPH-EGVIIFDNVNFMYSPGGP--LVLKHLTALIKSQEKVGIVG 1075
L+++ P W + +G I F + F Y P P VL L+ I + + VG
Sbjct: 1055 LDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTY-PSRPDSQVLNGLSVSISPGQTLAFVG 1113
Query: 1076 RTGAGKSSLISALFRLSEPE-GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKN 1134
+G GKS+ I L R +P+ GK+ ID + ++ + LR + I+ QEPVLF ++ N
Sbjct: 1114 SSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDN 1173
Query: 1135 L---DPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAI 1191
+ D E E + A ++ QL + + LP K +T + GS S G++Q + +ARAI
Sbjct: 1174 IKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAI 1233
Query: 1192 LRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGR 1251
+R +IL++DEAT+ +D +++ +Q + + T + IAHRL+TI ++D I V+ G
Sbjct: 1234 VRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGV 1293
Query: 1252 LKEYDEPYVLLQNKESLFYKMV 1273
+ E L+ K +YK+V
Sbjct: 1294 VIEKGTHEELMAQK-GAYYKLV 1314
Score = 106 bits (264), Expect = 2e-22
Identities = 98/376 (26%), Positives = 172/376 (45%), Gaps = 43/376 (11%)
Query: 277 NEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVT- 335
NE ++ IR + E+ F + +K ++ + + G F+ ++ I+F+
Sbjct: 941 NEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGF----CFAFAQCIMFIAN 996
Query: 336 -----FTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFL 390
+ Y++ + S VF ++ AV L+ T + S A I + F
Sbjct: 997 SASYRYGGYLISNEGLHFSYVFRVIS---AVVLSATALGRAFSYTPSYAKAKISAARFFQ 1053
Query: 391 LLDE---ISQRNRQLPSDGKKMVHVQDFTAFWD------KASETPTLQGLSFTVRPGELL 441
LLD IS N + G+K + Q F D ++ L GLS ++ PG+ L
Sbjct: 1054 LLDRQPPISVYN----TAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTL 1109
Query: 442 AVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-------------IAYVSQQPWVFSGT 488
A VG G GKS+ + + P G V + G I VSQ+P +F+ +
Sbjct: 1110 AFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACS 1169
Query: 489 LRSNILFGKKYEKERYEKVI---KACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNL 545
+ NI +G ++ E+VI K L + L + T +G +G+ LS G+K R+ +
Sbjct: 1170 IMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAI 1229
Query: 546 ARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILI 605
ARA+ +D I LLD+ SA+D E S ++ + + + I++ H+L ++ A I +
Sbjct: 1230 ARAIVRDPKILLLDEATSALDTE-SEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAV 1288
Query: 606 LKDGKMVQKGTYTEFL 621
+ G +++KGT+ E +
Sbjct: 1289 MAQGVVIEKGTHEELM 1304
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B isoform
1 [Homo sapiens]
Length = 703
Score = 147 bits (370), Expect = 9e-35
Identities = 124/497 (24%), Positives = 245/497 (49%), Gaps = 22/497 (4%)
Query: 788 YVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTL 847
Y + + + ++F S+L+ + FF G + +R S D + + LPL +++L
Sbjct: 216 YTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSL 275
Query: 848 LQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSS 907
++VVG+ +++ P + + + I + + ++V R + + +
Sbjct: 276 VKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREA 335
Query: 908 LQGLWTIRAYKAEE----RCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIV 963
+ GL T+R++ AEE R +E + + L+ W L + + VR + ++++
Sbjct: 336 VGGLQTVRSFGAEEHEVCRYKEALEQCRQLY---WRRDLERALYLLVRRVLHLGVQMLML 392
Query: 964 AFGSLILAK-TLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKE 1022
+ G + L G + + Y ++ Q V ++ + + + E+V Y D +
Sbjct: 393 SCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPN 452
Query: 1023 APWEYQKRPPPAWPHEGVIIFDNVNFMYS--PGGPLVLKHLTALIKSQEKVGIVGRTGAG 1080
P P +GV+ F +V+F Y P P VLK LT ++ E +VG G+G
Sbjct: 453 LPSPGTLAPTTL---QGVVKFQDVSFAYPNRPDRP-VLKGLTFTLRPGEVTALVGPNGSG 508
Query: 1081 KSSLISALFRLSEPEG-KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD-PF 1138
KS++ + L L +P G ++ +D+ ++ L ++ + QEPVLF+G++R N+
Sbjct: 509 KSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGL 568
Query: 1139 NEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQIL 1198
D+++ A Q + I+++ + T++ E GS + GQ+Q + +ARA++R ++L
Sbjct: 569 QSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVL 628
Query: 1199 IIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEP 1258
I+DEAT+ +D + ++ +Q TVL IAHRL + + +I+VL G+L++ +
Sbjct: 629 ILDEATSALDVQCEQALQD--WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQ- 685
Query: 1259 YVLLQNKESLFYKMVQQ 1275
LQ + L+ ++VQQ
Sbjct: 686 ---LQEGQDLYSRLVQQ 699
Score = 121 bits (303), Expect = 5e-27
Identities = 73/235 (31%), Positives = 132/235 (56%), Gaps = 24/235 (10%)
Query: 398 RNRQLPSDG-------KKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG 450
R LPS G + +V QD + + + P L+GL+FT+RPGE+ A+VGP G+G
Sbjct: 449 RQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSG 508
Query: 451 KSSLLSAVLGELAPSHGLV-------------SVHGRIAYVSQQPWVFSGTLRSNILFG- 496
KS++ + + P+ G V +H ++ V Q+P +FSG++R+NI +G
Sbjct: 509 KSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGL 568
Query: 497 KKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIY 556
+ E ++ +A +Q +E G T +G++G+ L+ GQK R+ +ARA+ +D +
Sbjct: 569 QSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVL 628
Query: 557 LLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKM 611
+LD+ SA+D + + L + ++ +++ H+LQ ++ A QIL+L++GK+
Sbjct: 629 ILDEATSALDVQCEQALQD---WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,513,645
Number of Sequences: 37866
Number of extensions: 1928556
Number of successful extensions: 5894
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 5219
Number of HSP's gapped (non-prelim): 275
length of query: 1325
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1211
effective length of database: 13,930,794
effective search space: 16870191534
effective search space used: 16870191534
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.