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Search of human proteins with 157168349
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157168349 F-box and leucine-rich repeat protein 19 [Homo
sapiens]
(694 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapi... 1459 0.0
gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [... 594 e-169
gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [... 593 e-169
gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] 294 2e-79
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 69 1e-11
gi|156142182 CXXC finger 1 (PHD domain) isoform 1 [Homo sapiens] 68 3e-11
gi|156142180 CXXC finger 1 (PHD domain) isoform 2 [Homo sapiens] 68 3e-11
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] 68 3e-11
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin... 63 8e-10
gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] 61 3e-09
gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] 60 9e-09
gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Ho... 58 3e-08
gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo... 58 3e-08
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 56 1e-07
gi|122937267 lemur tyrosine kinase 3 [Homo sapiens] 55 2e-07
gi|117306167 proline-rich protein BstNI subfamily 3 precursor [H... 55 2e-07
gi|112734870 hypothetical protein LOC57648 [Homo sapiens] 55 3e-07
gi|21464115 methyl-CpG binding domain protein 1 isoform 2 [Homo ... 54 4e-07
gi|18959210 WIRE protein [Homo sapiens] 54 5e-07
gi|58530845 zyxin [Homo sapiens] 53 1e-06
gi|4508047 zyxin [Homo sapiens] 53 1e-06
gi|37537692 proline-rich protein BstNI subfamily 4 precursor [Ho... 53 1e-06
gi|31324577 molecule interacting with Rab13 [Homo sapiens] 53 1e-06
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap... 52 1e-06
gi|21464119 methyl-CpG binding domain protein 1 isoform PCM1 [Ho... 52 1e-06
gi|21464117 methyl-CpG binding domain protein 1 isoform 1 [Homo ... 52 1e-06
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 52 1e-06
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens] 52 2e-06
gi|190194416 F-box and leucine-rich repeat protein 15 [Homo sapi... 52 2e-06
gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ... 52 2e-06
>gi|157168349 F-box and leucine-rich repeat protein 19 [Homo
sapiens]
Length = 694
Score = 1459 bits (3776), Expect = 0.0
Identities = 694/694 (100%), Positives = 694/694 (100%)
Query: 1 MGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMK 60
MGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMK
Sbjct: 1 MGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMK 60
Query: 61 KFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEI 120
KFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEI
Sbjct: 61 KFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEI 120
Query: 121 VHPGCLKMGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGW 180
VHPGCLKMGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGW
Sbjct: 121 VHPGCLKMGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGW 180
Query: 181 KLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKK 240
KLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKK
Sbjct: 181 KLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKK 240
Query: 241 VGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSP 300
VGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSP
Sbjct: 241 VGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSP 300
Query: 301 SPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGS 360
SPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGS
Sbjct: 301 SPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGS 360
Query: 361 SGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGS 420
SGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGS
Sbjct: 361 SGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGS 420
Query: 421 DHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGV 480
DHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGV
Sbjct: 421 DHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGV 480
Query: 481 VRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLR 540
VRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLR
Sbjct: 481 VRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLR 540
Query: 541 WIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLS 600
WIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLS
Sbjct: 541 WIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLS 600
Query: 601 ALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLR 660
ALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLR
Sbjct: 601 ALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLR 660
Query: 661 SCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS 694
SCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS
Sbjct: 661 SCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS 694
>gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [Homo
sapiens]
Length = 1265
Score = 594 bits (1531), Expect = e-169
Identities = 318/710 (44%), Positives = 429/710 (60%), Gaps = 59/710 (8%)
Query: 8 KGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGR 67
KG+ GP++ + + ++ AGARRRRTRCR+C AC+RTECG+CHFC+DMKKFGGPGR
Sbjct: 555 KGKLGPASAVKLAANRTT----AGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGR 610
Query: 68 MKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLK 127
MKQSC++RQC APVLPHTAVCL+CGEAGKEDTVE EE KF L LMEC+ICNEI+HPGCLK
Sbjct: 611 MKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLK 670
Query: 128 MGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPP 187
+ ++EGV+N E+PNCWECP+C G+T K GPG + A N SL K+ +
Sbjct: 671 IKESEGVVNDELPNCWECPKCNHAGKTGKQK-RGPGFKYASNLP--GSLLKEQKMNRD-- 725
Query: 188 LPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTP-----------RKKVKGGRER 236
++G PA E P +R + + PP RKK K + +
Sbjct: 726 ------NKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQ 779
Query: 237 HLK-----KVGGDACLLRGSDPGGPGLLPPRVL--NPSQAFSSCH----PGLPPENWEKP 285
L K G + L R L P + F P PP+ E
Sbjct: 780 ELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESD 839
Query: 286 K---------PPLASAEGPAVPSPSPQREKL---------ERFKRMCQLLERVPDTSSSS 327
P AEGP R K E K + ++R ++ ++
Sbjct: 840 HSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANE 899
Query: 328 SDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGGP--LLSWP 385
+ S+ PG R ++G +G R R + P P ++S P
Sbjct: 900 NQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTP--RELRHQLGPSLRSPPRVISRP 957
Query: 386 LGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCICM 445
PP+ Q+ERHV+RPPP SP PD+LPL G+ H + R W+ VF +L ++LC+CM
Sbjct: 958 PPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCM 1017
Query: 446 RVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLN 505
RVCRTW+RWC DKRLW R+DL+ KS+TP MLSG++RRQP +LDLSWT +SKKQL WL+N
Sbjct: 1018 RVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLIN 1077
Query: 506 RLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQT 565
RL GL++LVLSGCSW++VSAL S+ P LR LD++W+E +KD+Q+R+LL PP D +PGQ
Sbjct: 1078 RLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQM 1137
Query: 566 ESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPL 625
++R +L+ + ELRLAGL++TDASLRL++RH P LS L LS+C HV D S++LLTA +
Sbjct: 1138 DNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTT 1197
Query: 626 RETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAA 675
R++L +NL+ C+++TD CL F+RC + +DLR C+Q++ E C + A
Sbjct: 1198 RDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIA 1247
>gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [Homo
sapiens]
Length = 1336
Score = 593 bits (1529), Expect = e-169
Identities = 339/768 (44%), Positives = 451/768 (58%), Gaps = 102/768 (13%)
Query: 8 KGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGR 67
KG+ GP++ + + ++ AGARRRRTRCR+C AC+RTECG+CHFC+DMKKFGGPGR
Sbjct: 586 KGKLGPASAVKLAANRTT----AGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGR 641
Query: 68 MKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLK 127
MKQSC++RQC APVLPHTAVCL+CGEAGKEDTVE EE KF L LMEC+ICNEI+HPGCLK
Sbjct: 642 MKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLK 701
Query: 128 MGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPP 187
+ ++EGV+N E+PNCWECP+C G+T K GPG + A N SL K+ +
Sbjct: 702 IKESEGVVNDELPNCWECPKCNHAGKTGKQK-RGPGFKYASNLP--GSLLKEQKMNRD-- 756
Query: 188 LPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTP-----------RKKVK----- 231
++G PA E P +R + + PP RKK K
Sbjct: 757 ------NKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQ 810
Query: 232 --GGRER--HLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKP 287
GR+R L+ G + L P G L P + + PG + + K +
Sbjct: 811 ELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRR 870
Query: 288 PLASAEGPAVPSPSPQREKLERFKRMCQ-LLERVPDTSSSSSDSDSDSDSSGTSLSEDEA 346
+AE + P L RFK+ + L P + S S S S ++G S E
Sbjct: 871 SWKNAEDRMALANKP----LRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEG 926
Query: 347 PGE------------------------------------ARNGRRPARG---SSGEKENR 367
P E A ++P + S GE+ R
Sbjct: 927 PEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKR 986
Query: 368 GGRRAVRPG------SGGPL-LSWPLGPA----------PPPR--PP---QLERHVVRPP 405
RP +G P L LGP+ PPP PP Q+ERHV+RPP
Sbjct: 987 PPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPP 1046
Query: 406 PRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMD 465
P SP PD+LPL G+ H + R W+ VF +L ++LC+CMRVCRTW+RWC DKRLW R+D
Sbjct: 1047 PISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRID 1106
Query: 466 LSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSA 525
L+ KS+TP MLSG++RRQP +LDLSWT +SKKQL WL+NRL GL++LVLSGCSW++VSA
Sbjct: 1107 LNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSA 1166
Query: 526 LGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELT 585
L S+ P LR LD++W+E +KD+Q+R+LL PP D +PGQ ++R +L+ + ELRLAGL++T
Sbjct: 1167 LCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDIT 1226
Query: 586 DASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCL 645
DASLRL++RH P LS L LS+C HV D S++LLTA + R++L +NL+ C+++TD CL
Sbjct: 1227 DASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCL 1286
Query: 646 PLFRRCPRLRRLDLRSCRQLSPEACAR-LAAAGPPGPFRCPEEKLLLK 692
F+RC + +DLR C+Q++ E C + +A F EEKLL K
Sbjct: 1287 SFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSVSVQFGQVEEKLLQK 1334
>gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens]
Length = 1162
Score = 294 bits (753), Expect = 2e-79
Identities = 143/277 (51%), Positives = 197/277 (71%), Gaps = 3/277 (1%)
Query: 419 GSDHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLS 478
G + + R W+ VF++L RELC CMRVC+TW +WC DKRLW ++DLSR K++ P LS
Sbjct: 888 GDESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALS 947
Query: 479 GVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLD 538
G+++RQP +LDLSWT +SKKQL WL+NRL GL++L+L+GCSW +VSAL ++ P LR LD
Sbjct: 948 GIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLD 1007
Query: 539 LRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQ 598
LRW +KD Q+R+LL PP D KPGQ ++R +L+ + + RLAGL++TDA+LRL++RH P
Sbjct: 1008 LRWAVGIKDPQIRDLLTPPAD-KPGQ-DNRSKLRNMTDFRLAGLDITDATLRLIIRHMPL 1065
Query: 599 LSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLD 658
LS LDLSHC+H+ D S +LLTA S R +L LN+AGC++LTD L RR + +D
Sbjct: 1066 LSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLID 1125
Query: 659 LRSCRQLSPEACARLAAAGPPGPFRC-PEEKLLLKDS 694
LR C+Q++ +AC + C +EKL+ K S
Sbjct: 1126 LRGCKQITRKACEHFISDLSINSLYCLSDEKLIQKIS 1162
Score = 198 bits (504), Expect = 1e-50
Identities = 96/182 (52%), Positives = 123/182 (67%), Gaps = 13/182 (7%)
Query: 13 PSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSC 72
P+ LTP +++ +GARRRR RCR+C+ACV+ ECG CH+CRDMKKFGGPGRMKQSC
Sbjct: 545 PAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSC 604
Query: 73 LLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAE 132
+LRQC AP LPH+ C LCGE + + + E+K LMEC ICNEIVHPGCL+M E
Sbjct: 605 VLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKK----LMECCICNEIVHPGCLQM-DGE 659
Query: 133 GVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEE---GASLGSGWKLTEEPPLP 189
G++N E+PNCWECP+C QE DS E +R+ + +E A + + +EP P
Sbjct: 660 GLLNEELPNCWECPKCYQE-----DSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTP 714
Query: 190 PP 191
PP
Sbjct: 715 PP 716
>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]
Length = 436
Score = 68.9 bits (167), Expect = 1e-11
Identities = 76/273 (27%), Positives = 115/273 (42%), Gaps = 27/273 (9%)
Query: 424 LPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDL-SRRKSLTPPMLSGVVR 482
LP+ LR+F L LC C +V R W+ D W R+DL ++ + ++ + +
Sbjct: 28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISK 87
Query: 483 RQP---RALDL-SWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAP--LPALRL 536
R R L L GV L + ++ L L+GC+ + + S LR
Sbjct: 88 RCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRH 147
Query: 537 LDLRWIEDVKDSQLRELLLPPP------------DTKPG-QTESRGRLQGVAELRLAG-L 582
LDL + + L+ L P TK G Q RG G+ L L G
Sbjct: 148 LDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRG-CGGLKALFLKGCT 206
Query: 583 ELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTD 642
+L D +L+ + H P+L L+L C + D + + L+ L +GC +TD
Sbjct: 207 QLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQS----LCASGCSNITD 262
Query: 643 HCL-PLFRRCPRLRRLDLRSCRQLSPEACARLA 674
L L + CPRLR L++ C QL+ LA
Sbjct: 263 AILNALGQNCPRLRILEVARCSQLTDVGFTTLA 295
Score = 55.8 bits (133), Expect = 1e-07
Identities = 71/274 (25%), Positives = 108/274 (39%), Gaps = 56/274 (20%)
Query: 448 CRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQP--RALDLSWTG-VSKKQLMWLL 504
C + S++C R +DL+ S+T L + P L++SW V+K + L+
Sbjct: 135 CTSLSKFCSKLR---HLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV 191
Query: 505 NRLQGLQELVLSGCSWLSVSALG--SAPLPALRLLDLRWIEDVKD--------------- 547
GL+ L L GC+ L AL A P L L+L+ + D
Sbjct: 192 RGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQS 251
Query: 548 ------SQLRELLLPPPDTKPGQTESRGRLQGVA------------------ELRLAGLE 583
S + + +L GQ R R+ VA EL LE
Sbjct: 252 LCASGCSNITDAIL----NALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLE 307
Query: 584 ----LTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHR 639
+TD++L L H P+L L LSHC + D + L + + L + L C
Sbjct: 308 ECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHL-GNGACAHDQLEVIELDNCPL 366
Query: 640 LTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARL 673
+TD L + C L R++L C+Q++ RL
Sbjct: 367 ITDASLEHLKSCHSLERIELYDCQQITRAGIKRL 400
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 12/103 (11%)
Query: 585 TDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLT-DH 643
TDA+ L + +L LDL+ C + + S+ L+ PL E LN++ C ++T D
Sbjct: 131 TDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGC-PLLE---QLNISWCDQVTKDG 186
Query: 644 CLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPE 686
L R C L+ L L+ C QL EA + A CPE
Sbjct: 187 IQALVRGCGGLKALFLKGCTQLEDEALKYIGA-------HCPE 222
Score = 37.7 bits (86), Expect = 0.036
Identities = 26/81 (32%), Positives = 36/81 (44%), Gaps = 5/81 (6%)
Query: 599 LSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDH-CLPLFRRCPRLRRL 657
L L L C VGD ++ + LNL GC + TD C L + C +LR L
Sbjct: 93 LRKLSLRGCLGVGDNALRTFAQNCRNIEV----LNLNGCTKTTDATCTSLSKFCSKLRHL 148
Query: 658 DLRSCRQLSPEACARLAAAGP 678
DL SC ++ + L+ P
Sbjct: 149 DLASCTSITNMSLKALSEGCP 169
>gi|156142182 CXXC finger 1 (PHD domain) isoform 1 [Homo sapiens]
Length = 660
Score = 67.8 bits (164), Expect = 3e-11
Identities = 33/69 (47%), Positives = 40/69 (57%), Gaps = 2/69 (2%)
Query: 10 ESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTE-CGDCHFCRDMKKFGGPGRM 68
+S P L+ P S + +R C C AC RTE CG C FCRDMKKFGGP ++
Sbjct: 141 KSSPQPLVATP-SQHHQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKI 199
Query: 69 KQSCLLRQC 77
+Q C LRQC
Sbjct: 200 RQKCRLRQC 208
>gi|156142180 CXXC finger 1 (PHD domain) isoform 2 [Homo sapiens]
Length = 656
Score = 67.8 bits (164), Expect = 3e-11
Identities = 33/69 (47%), Positives = 40/69 (57%), Gaps = 2/69 (2%)
Query: 10 ESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTE-CGDCHFCRDMKKFGGPGRM 68
+S P L+ P S + +R C C AC RTE CG C FCRDMKKFGGP ++
Sbjct: 141 KSSPQPLVATP-SQHHQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKI 199
Query: 69 KQSCLLRQC 77
+Q C LRQC
Sbjct: 200 RQKCRLRQC 208
>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
Length = 491
Score = 67.8 bits (164), Expect = 3e-11
Identities = 84/359 (23%), Positives = 141/359 (39%), Gaps = 51/359 (14%)
Query: 323 TSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEK----------ENRGGRRA 372
+SS SSD S +D + T ++ A E + + +N G
Sbjct: 16 SSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSST 75
Query: 373 VRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRV 432
G ++ P P L R RP D LP DH + +++
Sbjct: 76 SSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLP-----DHSM-----VQI 125
Query: 433 FQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSW 492
F L +LC C RVCR W +D RLW + L+G RAL +
Sbjct: 126 FSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI-----------RLTGETINVDRALKV-- 172
Query: 493 TGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAP--LPALRLLDLRWIEDVKDSQL 550
++++ N L+ + +SGC L+ L + P LR L++ ++ + +
Sbjct: 173 --LTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAV 230
Query: 551 RELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSA--LDLSHCA 608
+++ P+ + ++ ++ R +AS++L H Q+S LD++ C
Sbjct: 231 FDVVSLCPNLEHLDVSGCSKVTCISLTR-------EASIKLSPLHGKQISIRYLDMTDCF 283
Query: 609 HVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLP-LFRRCPRLRRLDLRSCRQLS 666
+ D +H + A + L HL L C RLTD L L C ++ L + CR +S
Sbjct: 284 VLEDEGLHTIAAHCT----QLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVS 338
Score = 35.4 bits (80), Expect = 0.18
Identities = 17/39 (43%), Positives = 25/39 (64%), Gaps = 1/39 (2%)
Query: 632 LNLAGCHRLTDHCL-PLFRRCPRLRRLDLRSCRQLSPEA 669
+ ++GC RLTD L + + CP LRRL++ C +S EA
Sbjct: 191 VTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEA 229
Score = 31.2 bits (69), Expect = 3.4
Identities = 25/109 (22%), Positives = 50/109 (45%), Gaps = 14/109 (12%)
Query: 577 LRLAGLELT-DASLRLLLRHAPQ--------LSALDLSHCAHVGDPSVHLLTAPTSPLRE 627
+RL G + D +L++L R Q L + +S C + D ++ + LR
Sbjct: 157 IRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRR 216
Query: 628 TLVHLNLAGCHRLTDHCL-PLFRRCPRLRRLDLRSCRQLSPEACARLAA 675
L ++GC+ +++ + + CP L LD+ C +++ + R A+
Sbjct: 217 ----LEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREAS 261
Score = 31.2 bits (69), Expect = 3.4
Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 584 LTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDH 643
+TD + L ++ +L +LD+ C V D + L L+ L+L C +T
Sbjct: 389 ITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLK----RLSLKSCESITGQ 444
Query: 644 CLPLF-RRCPRLRRLDLRSCRQLSPEA 669
L + C L+ L+++ C ++S EA
Sbjct: 445 GLQIVAANCFDLQTLNVQDC-EVSVEA 470
>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
tract binding protein associated) [Homo sapiens]
Length = 707
Score = 63.2 bits (152), Expect = 8e-10
Identities = 66/253 (26%), Positives = 90/253 (35%), Gaps = 73/253 (28%)
Query: 185 EPPLPPPPP--RRKGPLPAGPPPEDVP---GPPKRKEREAGNEPPTPRKKVKGGRERHLK 239
+PP+PPPPP +++ P P PPP+ P PP + + PP P+ K
Sbjct: 57 KPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQDSSK-------- 108
Query: 240 KVGGDACLLRGSDPG-GPGLLPPRVLNPSQAFSSCHPGLPPENWEKP---------KPPL 289
+ +G P G G PP A SS P PP + P PP
Sbjct: 109 -----PVVAQGPGPAPGVGSAPP-------ASSSAPPATPPTSGAPPGSGPGPTPTPPPA 156
Query: 290 ASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGE 349
++ P P P+P + P + + G + PG
Sbjct: 157 VTSAPPGAPPPTPPSSG----------VPTTPPQAGGPPPPPAAVPGPGPGPKQGPGPGG 206
Query: 350 ARNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLG-PAPPPR------------PPQ 396
+ G+ P GG +PG GGP LS P G P PP R PP
Sbjct: 207 PKGGKMP-----------GG---PKPG-GGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPY 251
Query: 397 LERHVVRPPPRSP 409
++H PPP P
Sbjct: 252 HQQHHQGPPPGGP 264
Score = 40.0 bits (92), Expect = 0.007
Identities = 28/78 (35%), Positives = 34/78 (43%), Gaps = 10/78 (12%)
Query: 348 GEARNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPR 407
G + R P G G +NRG P GP S P P PPP P Q ++ +PPP+
Sbjct: 26 GGLHDFRSPPPGM-GLNQNRG------PMGPGPGQSGPKPPIPPPPPHQQQQ---QPPPQ 75
Query: 408 SPEPDTLPLAAGSDHPLP 425
P P P HP P
Sbjct: 76 QPPPQQPPPHQPPPHPQP 93
Score = 38.5 bits (88), Expect = 0.021
Identities = 49/196 (25%), Positives = 59/196 (30%), Gaps = 10/196 (5%)
Query: 234 RERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAE 293
R+R + GG R GG G L F S PG+ P P
Sbjct: 3 RDRFRSRGGGGGGFHRRGGGGGRGGL--------HDFRSPPPGMGLNQNRGPMGPGPGQS 54
Query: 294 GPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNG 353
GP P P P + ++ Q + P +D + G
Sbjct: 55 GPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQDSSKPVVAQG 114
Query: 354 RRPARG-SSGEKENRGGRRAVRPGSGGPLLSWP-LGPAPPPRPPQLERHVVRPPPRSPEP 411
PA G S + A P SG P S P P PPP P P S
Sbjct: 115 PGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGV 174
Query: 412 DTLPLAAGSDHPLPRA 427
T P AG P P A
Sbjct: 175 PTTPPQAGGPPPPPAA 190
Score = 35.0 bits (79), Expect = 0.23
Identities = 45/162 (27%), Positives = 52/162 (32%), Gaps = 29/162 (17%)
Query: 173 GASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRK---- 228
GA GSG P P PPP P PPP +AG PP P
Sbjct: 140 GAPPGSG-----PGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGP 194
Query: 229 -----------KVKGGRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGL 277
KGG+ K GG L S PGG P R + HP
Sbjct: 195 GPGPKQGPGPGGPKGGKMPGGPKPGGGPGL---STPGGHPKPPHRGGGEPRGGRQHHPPY 251
Query: 278 PPENWEKPKPPLASAEGPAVPSPSPQREKLERFKRMCQLLER 319
++ + P P GP S + E FK LL R
Sbjct: 252 HQQHHQGPPP-----GGPGGRSEEKISDS-EGFKANLSLLRR 287
>gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]
Length = 423
Score = 61.2 bits (147), Expect = 3e-09
Identities = 70/272 (25%), Positives = 113/272 (41%), Gaps = 25/272 (9%)
Query: 424 LPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDL-SRRKSLTPPMLSGVVR 482
LP+ LR+F L LC C ++ + W+ D W R+DL + + + ++ + +
Sbjct: 15 LPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQIDVEGRVVENISK 74
Query: 483 RQP---RALDL-SWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAP--LPALRL 536
R R L L GV L + ++ L L+GC+ ++ S S L+
Sbjct: 75 RCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKH 134
Query: 537 LDLRWIEDVKDSQLR------------ELLLPPPDTKPGQTESRGRLQGVAELRLAG-LE 583
LDL + +S L+ L TK G +G+ L L G +
Sbjct: 135 LDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGCRGLKALLLRGCTQ 194
Query: 584 LTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDH 643
L D +L+ + + +L +L+L C+ + D V + L+ L L+GC LTD
Sbjct: 195 LEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQA----LCLSGCSNLTDA 250
Query: 644 CL-PLFRRCPRLRRLDLRSCRQLSPEACARLA 674
L L CPRL+ L+ C L+ LA
Sbjct: 251 SLTALGLNCPRLQILEAARCSHLTDAGFTLLA 282
Score = 60.5 bits (145), Expect = 5e-09
Identities = 75/275 (27%), Positives = 111/275 (40%), Gaps = 48/275 (17%)
Query: 448 CRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVR--RQPRALDLSWTG-VSKKQLMWLL 504
C + SR+C + +DL+ S+T L G+ R L+LSW ++K + L+
Sbjct: 122 CYSLSRFCSKLK---HLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALV 178
Query: 505 NRLQGLQELVLSGCSWLSVSALG----------SAPLPA------------------LRL 536
+GL+ L+L GC+ L AL S L + L+
Sbjct: 179 RGCRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQA 238
Query: 537 LDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVA---------ELRLAGLE---- 583
L L ++ D+ L L L P + + L EL LE
Sbjct: 239 LCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECIL 298
Query: 584 LTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDH 643
+TD++L L H P+L AL LSHC + D + L+ T E L L L C +TD
Sbjct: 299 ITDSTLIQLSIHCPKLQALSLSHCELITDDGILHLSNSTCG-HERLRVLELDNCLLITDV 357
Query: 644 CLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGP 678
L C L RL+L C+Q++ R+ A P
Sbjct: 358 ALEHLENCRGLERLELYDCQQVTRAGIKRMRAQLP 392
>gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens]
Length = 418
Score = 59.7 bits (143), Expect = 9e-09
Identities = 69/280 (24%), Positives = 107/280 (38%), Gaps = 57/280 (20%)
Query: 432 VFQHLGPRELCICMRVCRTWSRWCYDKRLW----PRMDLSRRKSLTPPMLSGVVRRQPRA 487
+F +L R+ +VC W Y K +W ++ L R P L R+ +
Sbjct: 16 IFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGIRRVQI 75
Query: 488 LDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSA---PLPALRLLDLRWIED 544
L L ++ L +++ + ++ L LSGC L+ + LG A + +LR L+L +
Sbjct: 76 LSL------RRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQ 129
Query: 545 VKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLE-LTDASLRLLLRHAPQLSALD 603
+ DS L + L+G+ L L G +T+ L L+ +L +L+
Sbjct: 130 ITDSSLGRIAQ--------------YLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLN 175
Query: 604 LSHCAHVGDPSVHLLTAPTSPLRET---LVHLNLAGCHRLTDHCLPLFRR---------- 650
L C H+ D + L T E L L L C +LTD L R
Sbjct: 176 LRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNL 235
Query: 651 ----------------CPRLRRLDLRSCRQLSPEACARLA 674
LR L+LRSC +S LA
Sbjct: 236 SFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLA 275
Score = 47.4 bits (111), Expect = 5e-05
Identities = 46/189 (24%), Positives = 81/189 (42%), Gaps = 20/189 (10%)
Query: 486 RALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRL--LDLRWIE 543
R L+LS+ G + L+ + L+ L L C +S + + + +LRL LD+ + +
Sbjct: 231 RLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCD 290
Query: 544 DVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALD 603
V D L + ++G L G+ L L ++D + ++R L L+
Sbjct: 291 KVGDQSLAYI-------------AQG-LDGLKSLSLCSCHISDDGINRMVRQMHGLRTLN 336
Query: 604 LSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCR 663
+ C + D + L+ S L ++L GC R+T L + P L+ L+L +
Sbjct: 337 IGQCVRITDKGLELIAEHLSQL----TGIDLYGCTRITKRGLERITQLPCLKVLNLGLWQ 392
Query: 664 QLSPEACAR 672
E AR
Sbjct: 393 MTDSEKEAR 401
>gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Homo
sapiens]
Length = 1632
Score = 57.8 bits (138), Expect = 3e-08
Identities = 23/43 (53%), Positives = 28/43 (65%)
Query: 35 RRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQC 77
+R RC C C + ECG C C+DM KFGG GR KQ+C R+C
Sbjct: 665 KRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRC 707
>gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo
sapiens]
Length = 1616
Score = 57.8 bits (138), Expect = 3e-08
Identities = 23/43 (53%), Positives = 28/43 (65%)
Query: 35 RRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQC 77
+R RC C C + ECG C C+DM KFGG GR KQ+C R+C
Sbjct: 649 KRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRC 691
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 55.8 bits (133), Expect = 1e-07
Identities = 29/68 (42%), Positives = 35/68 (51%), Gaps = 4/68 (5%)
Query: 11 SGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTE-CGDCHFCRDMKKFGGPGRMK 69
SG + TP S S G + R RC CR C+R + CG C C D KFGGP K
Sbjct: 941 SGGTLAHTPRRSLPSHH---GKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKK 997
Query: 70 QSCLLRQC 77
Q C+ R+C
Sbjct: 998 QCCVYRKC 1005
Score = 45.1 bits (105), Expect = 2e-04
Identities = 68/281 (24%), Positives = 90/281 (32%), Gaps = 57/281 (20%)
Query: 186 PPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKKVGGDA 245
PP P PPP P + PPP P PP + PP P ++ + E V
Sbjct: 408 PPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQ--EESPPPVVPATC 465
Query: 246 CLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKP-PLASAEGPAVPSPSPQR 304
RG P L PSQ PE P P P + GP SP+
Sbjct: 466 SRKRGRPP----------LTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAP 515
Query: 305 EKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEK 364
+ K + Q + +P S+ SS E RP +S
Sbjct: 516 KSTTFLKNIRQFI--MPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPV 573
Query: 365 ENRGGRRAVRPGSGGPLLSWPLGPAPPPRP---PQLERHVVR------------------ 403
P P+ S P P PP P P+ R ++R
Sbjct: 574 ----------PQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPP 623
Query: 404 --PPPRSPEPDTLPLAAGSDHPL--------PRAAWLRVFQ 434
PPP +P P P A S PL P A L++++
Sbjct: 624 APPPPPAPSPPPAP-ATSSRRPLLLRAPQFTPSEAHLKIYE 663
Score = 42.0 bits (97), Expect = 0.002
Identities = 67/274 (24%), Positives = 93/274 (33%), Gaps = 55/274 (20%)
Query: 186 PPL--PPPPPRRKGPLPAGPPP------EDVPGP--PKRKEREAGNEPPTP-----RKKV 230
PPL PPPPP PLP+ PPP E+ P P P R+ G P TP R+
Sbjct: 426 PPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAA 485
Query: 231 KGGRERHLKKVGGDACLLRGSDPGGPGLLPP---------------------RVLNPSQA 269
+ G E + G P + P RV+ +
Sbjct: 486 RAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRR 545
Query: 270 FSSCHPGLPPENWEKP--KPPLASA----EGPAVPSPSPQREKLERF-------KRMCQL 316
F P PP+ P +PP+ ++ + PA P PSP R KR L
Sbjct: 546 FMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPA-PVPSPPRAPTPPSTPVPLPEKRRSIL 604
Query: 317 LERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPG 376
E +S + + + + P A + RRP + + +
Sbjct: 605 REPTFRWTSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYES 664
Query: 377 SGGPLLSWPLGP--APPPRPPQLERHVVRPPPRS 408
P PLG AP P PP + P PR+
Sbjct: 665 VLTPP---PLGAPEAPEPEPPPADDSPAEPEPRA 695
Score = 37.4 bits (85), Expect = 0.047
Identities = 71/257 (27%), Positives = 91/257 (35%), Gaps = 48/257 (18%)
Query: 177 GSGWKLTEEPPLPPPPPRRKGPLPA---GPPPED-------VPGPPKRKEREAGNEPPTP 226
G G E LPP PP G P+ P D +PG P + G P P
Sbjct: 2125 GDGGAGPREESLPPAPPLANGSQPSQGLTASPADPTRTFAWLPGAPGVRVLSLGPAPEPP 2184
Query: 227 RKKVKGGRERHLKKVGGDACLLRG-SDPGGPGL----LPPRVLNPSQAFSSCHPG----- 276
K + + K+G + G +P P + LPP + + + PG
Sbjct: 2185 --KPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTSWTLPPGPLLGV 2242
Query: 277 LPPENWEKPKPP-------LASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSD 329
LP +P PP L + GPA SP R+ + R KR+ R P
Sbjct: 2243 LPVVGVVRPAPPPPPPPLTLVLSSGPA----SPPRQAI-RVKRVSTFSGRSPPAPPPYKA 2297
Query: 330 SDSDSDSSGTSLSED--EAPGEARNGRRPARGSSGEKENRGGRRAVRPG------SGGPL 381
D D SED + PG G R + RG RPG S GPL
Sbjct: 2298 PRLDEDGEA---SEDTPQVPGLGSGGFSRVRMKT--PTVRGVLDLDRPGEPAGEESPGPL 2352
Query: 382 LS-WPLGPAPPPRPPQL 397
PL P P PPQ+
Sbjct: 2353 QERSPLLPLPEDGPPQV 2369
Score = 35.4 bits (80), Expect = 0.18
Identities = 60/259 (23%), Positives = 86/259 (33%), Gaps = 74/259 (28%)
Query: 187 PLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPT--------------------- 225
P PP RR PL PPP PP + + PPT
Sbjct: 1907 PAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPS 1966
Query: 226 -PRKKVKGGRERHLKKVGG-------DACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGL 277
P + G ++ V G A L G++P ++ + A S H G
Sbjct: 1967 PPPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIV------AAGAMGSSHGGP 2020
Query: 278 PPENWEKPKP-------PLASAEGPAV-PSPSPQREKLERFKRMCQLLERVPDTSSSSSD 329
+ E+ P P+ P + PS +P ++E+ L+ V D + S ++
Sbjct: 2021 GDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGAPRIEQ-------LDGVDDGTDSEAE 2073
Query: 330 SDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEK-------------ENRGGRRAVRPG 376
+ GT S PG R G A G +N GG PG
Sbjct: 2074 AVQQPRGQGTPPS---GPGVVRAGVLGAAGDRARPPEDLPSEIVDFVLKNLGG-----PG 2125
Query: 377 SGGPLLSWPLGPAPPPRPP 395
GG + P + PP PP
Sbjct: 2126 DGG---AGPREESLPPAPP 2141
Score = 35.0 bits (79), Expect = 0.23
Identities = 56/235 (23%), Positives = 76/235 (32%), Gaps = 33/235 (14%)
Query: 181 KLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPR------KKVKGGR 234
K+ E PPP + P P PP +D P P+ + N PR VK
Sbjct: 660 KIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEV 719
Query: 235 ERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPS---QAFSSCHPGLPPENWEKPKPPLAS 291
H G L G L P + L QA P L P + PPL
Sbjct: 720 SPH-----GAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEK 774
Query: 292 AEGPAV---PSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPG 348
A V P + + KR L ++ D + S S G + E
Sbjct: 775 ARIAGVGSLPLSGVEEKMFSLLKRAKVQLFKI-DQQQQQKVAASMPLSPGGQMEEVAGAV 833
Query: 349 EARNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVR 403
+ + R P R E + R P GP P + P++ +HV R
Sbjct: 834 KQISDRGPVRSEDESVEAKRER--------------PSGPESPVQGPRI-KHVCR 873
Score = 34.3 bits (77), Expect = 0.40
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 11/109 (10%)
Query: 180 WKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLK 239
W E P P PP + AG P E+V P +E+++ + + R+ VK +
Sbjct: 1030 WDSDESPEASPGPPGPRRGAGAGGPREEVVAHPGPEEQDSLLQRKSARRCVKQRPSYDIF 1089
Query: 240 KVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPP 288
+ D S+PGGP PR P + + P PE +P+ P
Sbjct: 1090 EDSDD------SEPGGPP--APRRRTPRE---NELPLPEPEEQSRPRKP 1127
Score = 31.6 bits (70), Expect = 2.6
Identities = 25/90 (27%), Positives = 34/90 (37%), Gaps = 20/90 (22%)
Query: 320 VPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGG 379
VP+ SS +SD + + G ED AP R+ R RG + R +
Sbjct: 108 VPEEESSDGESDEE-EFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTT------- 159
Query: 380 PLLSWPLGPAPPPRPPQLERHVVRPPPRSP 409
P PPPR V PP++P
Sbjct: 160 --------PLPPPRLAD----VAPTPPKTP 177
Score = 31.2 bits (69), Expect = 3.4
Identities = 58/243 (23%), Positives = 81/243 (33%), Gaps = 43/243 (17%)
Query: 143 WECPRCTQEGRTSKDSGEGPGR-----RRADNGEEGASLGSGWKLTEEPPLPPP------ 191
W PR + + G GP R + +GE G+ ++E P
Sbjct: 84 WAGPRVQRGRGRGRGRGWGPSRGCVPEEESSDGESDEEEFQGFH-SDEDVAPSSLRSALR 142
Query: 192 PPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTP-RKKVKGGRERHLKKVGGDACLLRG 250
R + P G + P PP R A P TP RK+ + G ER ++ + L R
Sbjct: 143 SQRGRAPRGRGRKHKTTPLPPPRLADVAPTPPKTPARKRGEEGTERMVQAL--TELLRRA 200
Query: 251 SDPGGPGLLPPRVLNPSQAFSS--CHPGLPPENWEKPKPPLASAEGP-AVPSPSPQREKL 307
P P R PS S PG P + + + AE +P P P
Sbjct: 201 QAPQAP---RSRACEPSTPRRSRGRPPGRPAGPCRRKQQAVVVAEAAVTIPKPEPPPPV- 256
Query: 308 ERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEK-EN 366
VP + S + G PG R G + +RG G +
Sbjct: 257 ------------VPVKHQTGSWKCKEGPGPG--------PGTPRRGGQSSRGGRGGRGRG 296
Query: 367 RGG 369
RGG
Sbjct: 297 RGG 299
Score = 30.0 bits (66), Expect = 7.5
Identities = 31/111 (27%), Positives = 42/111 (37%), Gaps = 21/111 (18%)
Query: 140 PNCWECPRCTQEGRTSKDSGEGPG-------RRR-----------ADNGEEGASLGSGWK 181
P ++ PR ++G S+D+ + PG R R D E A S
Sbjct: 2292 PPPYKAPRLDEDGEASEDTPQVPGLGSGGFSRVRMKTPTVRGVLDLDRPGEPAGEESPGP 2351
Query: 182 LTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGN---EPPTPRKK 229
L E PL P P +P GPP + EA + EPP+P K
Sbjct: 2352 LQERSPLLPLPEDGPPQVPDGPPDLLLESQWHHYSGEASSSEEEPPSPDDK 2402
>gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
Length = 1489
Score = 55.5 bits (132), Expect = 2e-07
Identities = 89/349 (25%), Positives = 107/349 (30%), Gaps = 85/349 (24%)
Query: 127 KMGKAEGVINAEIPNCWECPRCTQEGRTSKDSGE----GPGRRRADNGEEGASLGSGW-- 180
K G E P PR GR SG G G G +GW
Sbjct: 1109 KNGTLEPGTERRAPETGGAPRAPGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVD 1168
Query: 181 ---KLTEEPPLPPPP---PRRKGPLPAGPPPEDVP-GPPKRKEREAGNE--------PPT 225
PPLPPPP PRR P P PE P G P + AG + PP
Sbjct: 1169 NTRPQPPPPPLPPPPEAQPRRLEPAPPRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPK 1228
Query: 226 PRKKVKGGRER-----HLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPE 280
P +K G E L G++ ++ LPP L P F P PP
Sbjct: 1229 PERK---GPEMPRLFLDLGPPQGNSEQIKARLSRLSLALPPLTLTP---FPGPGPRRPP- 1281
Query: 281 NWEKPKPPLASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTS 340
WE A E +P P E D D + D +++
Sbjct: 1282 -WEGADAGAAGGEAGGAGAPGPAEE----------------DGEDEDEDEEEDEEAAAPG 1324
Query: 341 LSED-EAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLER 399
+ PG AR P SS + + A RP G LL P G A P +LER
Sbjct: 1325 AAAGPRGPGRARAAPVPVVVSSADAD------AARPLRG--LLKSPRG-ADEPEDSELER 1375
Query: 400 H-------------------------VVRPPPRSPEPDTLPLAAGSDHP 423
V PP +P T P HP
Sbjct: 1376 KRKMVSFHGDVTVYLFDQETPTNELSVQAPPEGDTDPSTPPAPPTPPHP 1424
Score = 42.4 bits (98), Expect = 0.001
Identities = 69/264 (26%), Positives = 92/264 (34%), Gaps = 60/264 (22%)
Query: 182 LTEEPPLPPPPPR--RKGPLP-------AGPPPEDVPGPPKRKEREAGNEPPTPRKKVKG 232
L+E PP PPPPP R GP P + P P + P + G +P +
Sbjct: 441 LSERPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPGADPDDVLTVTES 500
Query: 233 GRERHLKKVGGDACLLRGSDPGG------PGLLPPRV-LNPSQAF-------------SS 272
R +L+ + A RG+ GG P PP NPS F S+
Sbjct: 501 SRGLNLECLWEKA--RRGAGRGGGAPAWQPASAPPAPHANPSNPFYEALSTPSVLPVISA 558
Query: 273 CHP-------------GLPPE-----NWEKPKPPLASAEGPAVPSPSPQREKLERFKRMC 314
P G PPE +W+ P + + + P PS PQ +
Sbjct: 559 RSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPAPQAPQAPSEVPQLVSETWASPLF 618
Query: 315 QLLERVPDTSSSS-----SDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGG 369
P SS+S S D + +G +L+ D P E R A E+E G
Sbjct: 619 PAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGD--PAEVLGERGTAPWVEEEEEEEEG 676
Query: 370 RRAVRPGS---GGPLLSWPLGPAP 390
S GGP PL P P
Sbjct: 677 SSPGEDSSSLGGGPSRRGPL-PCP 699
Score = 42.0 bits (97), Expect = 0.002
Identities = 79/322 (24%), Positives = 116/322 (36%), Gaps = 80/322 (24%)
Query: 150 QEGRTSKDSG-----EGPGRRRADNG--EEGASLGSGWKLTEEPPLPPPP---------P 193
++G T++++G GPG R G + LG+G + P L P
Sbjct: 906 EKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNG---KQAPSLSLPVNGVTVLENGD 962
Query: 194 RRKGPLPAGPPPEDVPGPPKRKEREAGN-EPPTPRKKVKGGRERHLKKV-GGDACLLRGS 251
+R + G P+R+E+ N E PR++ K L+ G+ L+ G
Sbjct: 963 QRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENGELRSPEAGEKVLVNG- 1021
Query: 252 DPGGPGLLPPRVLNPSQAFSSCHPGL--------PPEN--WEKPKP----PLASAEGPAV 297
GL PP+ S+ S + GL PPE W P P P + P +
Sbjct: 1022 -----GLTPPK----SEDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTI 1072
Query: 298 PSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSG----TSLSEDEAPGEARN- 352
P+P+ LER P S+ S + + G + PG R
Sbjct: 1073 GEPAPETS-----------LERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRA 1121
Query: 353 ---GRRPARGSSGEKE-NRGGRRAVRPGS---GGP------LLSW-----PLGPAPP-PR 393
G P +G + GGR V G+ GGP W P P PP P
Sbjct: 1122 PETGGAPRAPGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPP 1181
Query: 394 PPQLERHVVRPPPRSPEPDTLP 415
PP+ + + P P P+ P
Sbjct: 1182 PPEAQPRRLEPAPPRARPEVAP 1203
Score = 33.9 bits (76), Expect = 0.52
Identities = 27/81 (33%), Positives = 31/81 (38%), Gaps = 10/81 (12%)
Query: 186 PPLPPPPPRRKGPLPAGP-PPEDVPGP------PKRKEREAGNE---PPTPRKKVKGGRE 235
PP PPPPPR A P PP V P P K ++G E P +P GG
Sbjct: 782 PPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGA 841
Query: 236 RHLKKVGGDACLLRGSDPGGP 256
+ V DPG P
Sbjct: 842 AEEEGVPRPRAPPEPPDPGAP 862
Score = 33.1 bits (74), Expect = 0.89
Identities = 79/311 (25%), Positives = 107/311 (34%), Gaps = 50/311 (16%)
Query: 162 PGRRRADNG--------EEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGP-P 212
PG + D+G EGA G G E P P PP P PPP+ P P P
Sbjct: 815 PGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLP 874
Query: 213 KRKEREAGNEPPTPRKKVKGGRERHLKKVGGDACLL--------RGSDPGG----PGL-L 259
+E+ + + + RE + + G+ G PG PGL
Sbjct: 875 GPREKPTFVVQVSTEQLLMSLREDVTRNLLGEKGATARETGPRKAGRGPGNREKVPGLNR 934
Query: 260 PPRVL-NPSQAFSSCHP--GLPP-ENWEKPKPPL--ASAEGPAVPSPSPQREKLERF--- 310
P VL N QA S P G+ EN ++ P + +AE A+ SP + + LE
Sbjct: 935 DPTVLGNGKQAPSLSLPVNGVTVLENGDQRAPGIEEKAAENGALGSPEREEKVLENGELT 994
Query: 311 --KRMCQLLE----RVPDTS---------SSSSDSDSDSDSSGTSLSED-EAPGEARNGR 354
+R + LE R P+ + D S++ G + E P E R
Sbjct: 995 PPRREEKALENGELRSPEAGEKVLVNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWR 1054
Query: 355 RPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTL 414
P EK A G P S PAP P P P P
Sbjct: 1055 AP---GPWEKTPESWGPAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGPAPKNG 1111
Query: 415 PLAAGSDHPLP 425
L G++ P
Sbjct: 1112 TLEPGTERRAP 1122
Score = 32.3 bits (72), Expect = 1.5
Identities = 59/260 (22%), Positives = 76/260 (29%), Gaps = 44/260 (16%)
Query: 184 EEPPLPPPP--PRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKKV 241
EE PP P P PL G P P P + +P R +
Sbjct: 572 EEHGSPPEPLFPNDWDPLDPGVPAPQAPQAPSEVPQLVSETWASPL--FPAPRPFPAQSS 629
Query: 242 GGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSPS 301
+ LL G DP G G +P++ G P W + + P S S
Sbjct: 630 ASGSFLLSGWDPEGRGAGETLAGDPAEVLGE--RGTAP--WVEEEEEEEEGSSPGEDSSS 685
Query: 302 PQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSS 361
R C L R + + + L + A G PA G
Sbjct: 686 LGGGPSRRGPLPCPLCSR---------------EGACSCLPLERGDAVAGWGGHPALGCP 730
Query: 362 GEKENRGGRRAVR----------PGSGGPLLSWPL-----------GPAPPPRPPQLERH 400
E+ RA R P S P PL GP P P PP
Sbjct: 731 HPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMGAAAPQYPGRGPPPAPPPPPPPPR 790
Query: 401 VVRPPPRSPEPDTLPLAAGS 420
P SP+P + + GS
Sbjct: 791 APADPAASPDPPSAVASPGS 810
>gi|117306167 proline-rich protein BstNI subfamily 3 precursor [Homo
sapiens]
Length = 309
Score = 55.5 bits (132), Expect = 2e-07
Identities = 77/300 (25%), Positives = 97/300 (32%), Gaps = 55/300 (18%)
Query: 149 TQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPL--------PPPPPRRKGPLP 200
+QE S SG+ GRR + + K PP PP P + +GP P
Sbjct: 24 SQEESPSVISGKPEGRRPQGGNQPQRTPPPPGKPEGRPPQGGNQSQGPPPRPGKPEGPPP 83
Query: 201 AG------PPPEDVPGPPKRKEREAGNEP--PTPRKKVKGGRERHLKKVGGDACLLRGSD 252
G PPP PG P+ + + GN+ P PR G+ GG+
Sbjct: 84 QGGNQSQGPPPR--PGKPEGQPPQGGNQSQGPPPRP----GKPEGPPPQGGNQSQGPPPR 137
Query: 253 PGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSPSPQREKLERFKR 312
PG P PP+ N SQ G PP + PP P P P +
Sbjct: 138 PGKPEGPPPQGGNQSQ-------GPPPRPGKPEGPPPQGGNQSQGPPPHPGK-------- 182
Query: 313 MCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAP--GEARNGRRPARGSSGEKENRGGR 370
P+ + S E P G G P G ++GG
Sbjct: 183 --------PEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPSQGGN 234
Query: 371 RAVRPGSGGPLLSWPLGPAP-----PPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLP 425
+ P P P GP P P RPP R PPP LP AG P
Sbjct: 235 K---PQGPPPHPGKPQGPPPQEGNKPQRPPPPGRPQGPPPPGGNPQQPLPPPAGKPQGPP 291
Score = 49.7 bits (117), Expect = 9e-06
Identities = 69/272 (25%), Positives = 88/272 (32%), Gaps = 51/272 (18%)
Query: 151 EGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPP---PRRKGPLPAGPPPED 207
EGR + + G EG G + PP P P P + G GPPP
Sbjct: 58 EGRPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGQPPQGGNQSQGPPPR- 116
Query: 208 VPGPPKRKEREAGNEP--PTPRKKVKGGRERHLKKVGGDACLLRGSDPGGPGLLPPRVLN 265
PG P+ + GN+ P PR G+ GG+ PG P PP+ N
Sbjct: 117 -PGKPEGPPPQGGNQSQGPPPRP----GKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGN 171
Query: 266 PSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSS 325
SQ G PP + PP P P P + E P
Sbjct: 172 QSQ-------GPPPHPGKPEGPPPQGGNQSQGPPPRPGKP------------EGPPPQGG 212
Query: 326 SSSDSD-------SDSDSSGTSLSEDEAPGEAR-NGRRPARGSSGEKENRGGRRAVRPGS 377
+ S S G + + P + G P G+ ++ GR P
Sbjct: 213 NQSQGPPPRPGKPEGPPSQGGNKPQGPPPHPGKPQGPPPQEGNKPQRPPPPGRPQGPPPP 272
Query: 378 GG-------PLLSWPLGPAPPP------RPPQ 396
GG P P GP PPP RPPQ
Sbjct: 273 GGNPQQPLPPPAGKPQGPPPPPQGGRPHRPPQ 304
Score = 36.2 bits (82), Expect = 0.11
Identities = 26/86 (30%), Positives = 36/86 (41%), Gaps = 17/86 (19%)
Query: 149 TQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDV 208
+Q G + PG+ + +EG +P PPPP R +GP P G P+
Sbjct: 230 SQGGNKPQGPPPHPGKPQGPPPQEG----------NKPQRPPPPGRPQGPPPPGGNPQQP 279
Query: 209 PGPPKRKEREAGNEPPTPRKKVKGGR 234
PP K + PP P +GGR
Sbjct: 280 LPPPAGKPQ---GPPPPP----QGGR 298
Score = 35.0 bits (79), Expect = 0.23
Identities = 39/124 (31%), Positives = 49/124 (39%), Gaps = 33/124 (26%)
Query: 336 SSGTSLSEDEAPGEARN-------GRRPARGSSGEKENRG-GRRAVRPGSGG-------P 380
SS SL+ED + E+ + GRRP G+ ++ G+ RP GG P
Sbjct: 14 SSAQSLNEDVSQEESPSVISGKPEGRRPQGGNQPQRTPPPPGKPEGRPPQGGNQSQGPPP 73
Query: 381 LLSWPLGP---------APPPRP-------PQLERHVVRPPPRSPEPDTLPLAAG--SDH 422
P GP PPPRP PQ PPPR +P+ P G S
Sbjct: 74 RPGKPEGPPPQGGNQSQGPPPRPGKPEGQPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQG 133
Query: 423 PLPR 426
P PR
Sbjct: 134 PPPR 137
>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
Length = 1094
Score = 54.7 bits (130), Expect = 3e-07
Identities = 78/257 (30%), Positives = 97/257 (37%), Gaps = 77/257 (29%)
Query: 189 PPPPPRRKGPL-------PAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKKV 241
PPPPPRR L P G P +P P+RK+ +P PR GG E
Sbjct: 497 PPPPPRRTHSLHQRGLAVPDG--PLGLPPKPERKQ-----QPQLPRPPTTGGSE----GA 545
Query: 242 GGDAC-------LLRGSDPGG---PGLLPPRVLNPSQAFSSCH--PGLPPENWEKPKPPL 289
G C + G PGG P P R L+PS +SS P LPP
Sbjct: 546 GAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPP---------- 595
Query: 290 ASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGE 349
+G A P SP + + + +R+ L R P S SSS + S SS D AP +
Sbjct: 596 ---KGLAGPPASPGKAQPPKPERVTSL--RSPGASVSSSLTSLCSSSS------DPAPSD 644
Query: 350 ARNGRRPARGSSGEKENRGGRRAVRP-GSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRS 408
R G + + P G + P PAP PP PRS
Sbjct: 645 -----------------RSGPQILTPLGDRFVIPPHPKVPAPFSPPPS--------KPRS 679
Query: 409 PEPDTLPLAAGSDHPLP 425
P P LAA + P P
Sbjct: 680 PNPAAPALAAPAVVPGP 696
Score = 41.6 bits (96), Expect = 0.003
Identities = 66/257 (25%), Positives = 91/257 (35%), Gaps = 26/257 (10%)
Query: 187 PLPPPPPRRKGPLPAGP---PPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKKVGG 243
P PPP + + P PA P P VPGP + + PPTP+ + +E + +
Sbjct: 669 PFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTD-ASPQSPPTPQTTLTPLQESPV--ISK 725
Query: 244 DACLLRGSDPG-----GPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVP 298
D P P P V+ A + L NW P PP + ++
Sbjct: 726 DQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMA 785
Query: 299 S-PSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGE-----ARN 352
P P+ E F + P S S + S SS T+L + + PG A
Sbjct: 786 DFPPPE----EAFFSVASPEPAGPSGSPELVSSPAASSSSATAL-QIQPPGSPDPPPAPP 840
Query: 353 GRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLG-PAPPPRPPQLER-HVVRPPPRSPE 410
PA + G + V GG +G P P Q+ R V P +P
Sbjct: 841 APAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPT 900
Query: 411 PDTLPLAAGSDHPLPRA 427
P P A PL RA
Sbjct: 901 PALGPSA--PQKPLRRA 915
Score = 38.1 bits (87), Expect = 0.028
Identities = 77/302 (25%), Positives = 99/302 (32%), Gaps = 73/302 (24%)
Query: 174 ASLGSGWKLTEEPP-LPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKG 232
AS S L +PP P PPP P PA P V P+++ PR+ V
Sbjct: 817 ASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDV-- 874
Query: 233 GRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASA 292
G + ++R G PG P L PS +KP S
Sbjct: 875 GAPLVTPSL---LQMVRLRSVGAPGGAPTPALGPSAP-------------QKPLRRALSG 918
Query: 293 EGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARN 352
VP+PS R K C L + S G S ++ P EA
Sbjct: 919 RASPVPAPSSGLHAAVRLK-ACSL-----------------AASEGLSSAQPNGPPEAE- 959
Query: 353 GRRPARGSSGEKE---NRGGR-----RAVRPGSGGPL----------LSWPLGPAPPPRP 394
RP + + ++G R R V P + L +S P P +
Sbjct: 960 -PRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKS 1018
Query: 395 PQLERHVVR------PPPRSP-----EPDTLPLAAGSDHPLPR-----AAWLRVFQHLGP 438
P+ V R PPP SP EP T P G H R A V Q +GP
Sbjct: 1019 PKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVLQLVGP 1078
Query: 439 RE 440
E
Sbjct: 1079 EE 1080
Score = 36.6 bits (83), Expect = 0.080
Identities = 56/260 (21%), Positives = 81/260 (31%), Gaps = 45/260 (17%)
Query: 173 GASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKG 232
GAS+ S P P R GP P + PP K + PP+
Sbjct: 623 GASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKP----- 677
Query: 233 GRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKP----P 288
R +P P L P V+ + + P PP P P
Sbjct: 678 ----------------RSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESP 721
Query: 289 LASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSD----------SDSSG 338
+ S + PSP P + +++ P S ++ + D +
Sbjct: 722 VISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQD 781
Query: 339 TSLSEDEAPGEA---RNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPP 395
S+++ P EA PA G SG E A + + P P PPP PP
Sbjct: 782 LSMADFPPPEEAFFSVASPEPA-GPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPP 840
Query: 396 ------QLERHVVRPPPRSP 409
HV + P + P
Sbjct: 841 APAPASSAPGHVAKLPQKEP 860
Score = 36.6 bits (83), Expect = 0.080
Identities = 63/251 (25%), Positives = 84/251 (33%), Gaps = 35/251 (13%)
Query: 184 EEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKE--REAGNEPPTPRKKVKGGRERHLKKV 241
++ P P PPP P P PE V P E E +P P E+ L
Sbjct: 726 DQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMA 785
Query: 242 GGDA-----CLLRGSDPGGPGLLPPRVLNPSQAFSSC------HPGLPPENWEKPKP-PL 289
+ +P GP P V +P+ + SS PG P P P P
Sbjct: 786 DFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPA 845
Query: 290 ASAEGPAVPSP-----------SPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSG 338
+SA G P P RE + LL+ V S + + + + G
Sbjct: 846 SSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMV-RLRSVGAPGGAPTPALG 904
Query: 339 TSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLE 398
S AP + R S + G AVR + S L A P PP+ E
Sbjct: 905 PS-----APQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAE 959
Query: 399 RHVVRPPPRSP 409
PP+SP
Sbjct: 960 PR----PPQSP 966
>gi|21464115 methyl-CpG binding domain protein 1 isoform 2 [Homo
sapiens]
Length = 586
Score = 54.3 bits (129), Expect = 4e-07
Identities = 31/78 (39%), Positives = 38/78 (48%), Gaps = 4/78 (5%)
Query: 4 KVPGKGESGPSALLTPPMSSSSRG--PGAGARRRRTR-CRRCRACVRT-ECGDCHFCRDM 59
K+ + G L PP S S P RR+ R C C AC+R +CG C FC D
Sbjct: 277 KMAARRRPGAQPLPPPPPSQSPEPTEPQPYTNRRQNRKCGACAACLRRMDCGRCDFCCDK 336
Query: 60 KKFGGPGRMKQSCLLRQC 77
KFGG + +Q C RQC
Sbjct: 337 PKFGGSNQKRQKCRWRQC 354
Score = 38.9 bits (89), Expect = 0.016
Identities = 50/199 (25%), Positives = 67/199 (33%), Gaps = 49/199 (24%)
Query: 24 SSRGPGAGARRRRTRCRRCRA-----------CVRTECGDCHFCRDMKKFGGPGRMKQSC 72
S G G +R +T C+ CRA R CG+C C+ + G +C
Sbjct: 139 SFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECAACQVTEDCGACS----TC 194
Query: 73 LLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAE 132
LL+ LPH L + + + E G C +C GC
Sbjct: 195 LLQ------LPHDVASGLFCKCERRRCLRIVERSRG-----CGVCR-----GCQTQ---- 234
Query: 133 GVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLG---SGWKLTEEP--- 186
+C CP C + R +RR G+ G S P
Sbjct: 235 -------EDCGHCPICLRPPRPGLRRQWKCVQRRCLRGKHARRKGGCDSKMAARRRPGAQ 287
Query: 187 PLPPPPPRRKGPLPAGPPP 205
PLPPPPP + P P P P
Sbjct: 288 PLPPPPPS-QSPEPTEPQP 305
>gi|18959210 WIRE protein [Homo sapiens]
Length = 440
Score = 53.9 bits (128), Expect = 5e-07
Identities = 60/249 (24%), Positives = 76/249 (30%), Gaps = 40/249 (16%)
Query: 168 DNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPR 227
D + +G K + P PPPP RR P P P +E+ PPTP
Sbjct: 158 DLSRPNTTSSTGMKHSSSAPPPPPPGRRANAPPTPLPMHSSKAPAYNREKPL---PPTPG 214
Query: 228 KKVKGGRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKP 287
+++ GRE GP PP + P + + G ++ P P
Sbjct: 215 QRLHPGRE-------------------GPPAPPP--VKPPPSPVNIRTGPSGQSLAPPPP 253
Query: 288 PLASAEGPAVPSPSPQREKLERFKRMCQLLER-----------VPDTSSSSS-----DSD 331
P G SP E + L R P TS+S S
Sbjct: 254 PYRQPPGVPNGPSSPTNESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPP 313
Query: 332 SDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPP 391
D + P RNG R A G R P P GP PP
Sbjct: 314 PARDPPSRGAAPPPPPPVIRNGARDAPPPPPPYRMHGSEPPSRGKPPPPPSRTPAGPPPP 373
Query: 392 PRPPQLERH 400
P PP H
Sbjct: 374 PPPPLRNGH 382
Score = 43.5 bits (101), Expect = 7e-04
Identities = 66/270 (24%), Positives = 93/270 (34%), Gaps = 50/270 (18%)
Query: 187 PLPPPPPRRKGPLPAGPPP-----EDVPGPPKRKEREAGNE-------PPTPRKKVKGGR 234
P+PPPPP P P PPP + P ++ + G T KKV
Sbjct: 2 PIPPPPP----PPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNIN 57
Query: 235 ERH---LKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPG--------------- 276
+R L+K G + G GG L P L G
Sbjct: 58 DRSAPILEKPKGSS---GGYGSGGAALQPKGGLFQGGVLKLRPVGAKDGSENLAGKPALQ 114
Query: 277 LPPENWEKPKPPLASAEGPAVPSPSPQREKLERFKRMCQL----LERVPDTSSSSSDSDS 332
+P P+PP+++A G R L RM + L R P+T+SS+ S
Sbjct: 115 IPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSR-PNTTSSTGMKHS 173
Query: 333 DS----DSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGP 388
S G + P + + PA G+R + PG GP P+ P
Sbjct: 174 SSAPPPPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQR-LHPGREGPPAPPPVKP 232
Query: 389 APPP---RPPQLERHVVRPPPRSPEPDTLP 415
P P R + + PPP +P +P
Sbjct: 233 PPSPVNIRTGPSGQSLAPPPPPYRQPPGVP 262
Score = 31.6 bits (70), Expect = 2.6
Identities = 21/60 (35%), Positives = 23/60 (38%), Gaps = 11/60 (18%)
Query: 187 PLPPPPPRRKGPLPAGPPP-------EDVPG----PPKRKEREAGNEPPTPRKKVKGGRE 235
P PPPP R G A PPP + P PP AG PP P G R+
Sbjct: 325 PPPPPPVIRNGARDAPPPPPPYRMHGSEPPSRGKPPPPPSRTPAGPPPPPPPPLRNGHRD 384
>gi|58530845 zyxin [Homo sapiens]
Length = 572
Score = 52.8 bits (125), Expect = 1e-06
Identities = 69/267 (25%), Positives = 100/267 (37%), Gaps = 47/267 (17%)
Query: 189 PPPPPRRKGPLPAGPPPEDV-PGPPKRKEREAGNE-----PPTPRKKVKGGRERHLKKVG 242
PPPPP + P P E++ P PP E E G E PP PR+KV + + +
Sbjct: 94 PPPPPPIEESFPPAPLEEEIFPSPPPPPEEEGGPEAPIPPPPQPREKV-SSIDLEIDSLS 152
Query: 243 GDACLLRGSDP----GGPGLLPPRVLNPSQAFSSCHPG------LPPENWEKP--KPPLA 290
+ +DP G +PP V P + SS P LPP W+ P PL
Sbjct: 153 SLLDDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKPAAGGTAPLPP--WKSPSSSQPLP 210
Query: 291 SAEGPA--------VPSPSPQREKLERFKRMCQLLERV-------PDTSSSSSDSDSDSD 335
PA P P P+ + + Q + P +S + + S
Sbjct: 211 QVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAPKFSPVT 270
Query: 336 SSGTSLSEDEAPGEARNGRRPARGSSGEKENR--GGRRAVRPGSGGPL-LSWPLGPAPPP 392
T ++ +PG A G SG + N+ G A+ G+G P S+
Sbjct: 271 PKFTPVASKFSPG--------APGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREK 322
Query: 393 RPPQLERHVVRPPPRSPEPDTLPLAAG 419
Q ++H V PP ++ P A G
Sbjct: 323 PRVQEKQHPVPPPAQNQNQVRSPGAPG 349
Score = 46.2 bits (108), Expect = 1e-04
Identities = 58/230 (25%), Positives = 75/230 (32%), Gaps = 30/230 (13%)
Query: 187 PLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKKVGGDAC 246
P+ P P+ P P PG + + G PP P + + GD
Sbjct: 28 PVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRVGEIPPPPPEDF----PLPPPPLAGD-- 81
Query: 247 LLRGSDPGGP--GLLPPRVLNPSQAFSSCHPGLPPEN--WEKPKPPLASAEGPAVPSPSP 302
G D G G PP P P P E + P PP GP P P P
Sbjct: 82 ---GDDAEGALGGAFPP----PPPPIEESFPPAPLEEEIFPSPPPPPEEEGGPEAPIPPP 134
Query: 303 --QREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGS 360
REK+ ++ D+ SS D + +D +S P P
Sbjct: 135 PQPREKVSS-------IDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVAT---PFSSK 184
Query: 361 SGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPE 410
S K GG + P P S PL P P Q + HV P P+
Sbjct: 185 SSTKPAAGGTAPLPPWK-SPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQ 233
>gi|4508047 zyxin [Homo sapiens]
Length = 572
Score = 52.8 bits (125), Expect = 1e-06
Identities = 69/267 (25%), Positives = 100/267 (37%), Gaps = 47/267 (17%)
Query: 189 PPPPPRRKGPLPAGPPPEDV-PGPPKRKEREAGNE-----PPTPRKKVKGGRERHLKKVG 242
PPPPP + P P E++ P PP E E G E PP PR+KV + + +
Sbjct: 94 PPPPPPIEESFPPAPLEEEIFPSPPPPPEEEGGPEAPIPPPPQPREKV-SSIDLEIDSLS 152
Query: 243 GDACLLRGSDP----GGPGLLPPRVLNPSQAFSSCHPG------LPPENWEKP--KPPLA 290
+ +DP G +PP V P + SS P LPP W+ P PL
Sbjct: 153 SLLDDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKPAAGGTAPLPP--WKSPSSSQPLP 210
Query: 291 SAEGPA--------VPSPSPQREKLERFKRMCQLLERV-------PDTSSSSSDSDSDSD 335
PA P P P+ + + Q + P +S + + S
Sbjct: 211 QVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAPKFSPVT 270
Query: 336 SSGTSLSEDEAPGEARNGRRPARGSSGEKENR--GGRRAVRPGSGGPL-LSWPLGPAPPP 392
T ++ +PG A G SG + N+ G A+ G+G P S+
Sbjct: 271 PKFTPVASKFSPG--------APGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREK 322
Query: 393 RPPQLERHVVRPPPRSPEPDTLPLAAG 419
Q ++H V PP ++ P A G
Sbjct: 323 PRVQEKQHPVPPPAQNQNQVRSPGAPG 349
Score = 46.2 bits (108), Expect = 1e-04
Identities = 58/230 (25%), Positives = 75/230 (32%), Gaps = 30/230 (13%)
Query: 187 PLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKKVGGDAC 246
P+ P P+ P P PG + + G PP P + + GD
Sbjct: 28 PVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRVGEIPPPPPEDF----PLPPPPLAGD-- 81
Query: 247 LLRGSDPGGP--GLLPPRVLNPSQAFSSCHPGLPPEN--WEKPKPPLASAEGPAVPSPSP 302
G D G G PP P P P E + P PP GP P P P
Sbjct: 82 ---GDDAEGALGGAFPP----PPPPIEESFPPAPLEEEIFPSPPPPPEEEGGPEAPIPPP 134
Query: 303 --QREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGS 360
REK+ ++ D+ SS D + +D +S P P
Sbjct: 135 PQPREKVSS-------IDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVAT---PFSSK 184
Query: 361 SGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPE 410
S K GG + P P S PL P P Q + HV P P+
Sbjct: 185 SSTKPAAGGTAPLPPWK-SPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQ 233
>gi|37537692 proline-rich protein BstNI subfamily 4 precursor [Homo
sapiens]
Length = 247
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/236 (24%), Positives = 77/236 (32%), Gaps = 54/236 (22%)
Query: 185 EPPLPPPPP-RRKGPLP------AGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERH 237
+P PPPPP + +GP P GPPP PG P+ + + GN+ P
Sbjct: 46 QPQRPPPPPGKPQGPPPQGGNQSQGPPPP--PGKPEGRPPQGGNQSQGP----------- 92
Query: 238 LKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAV 297
PG P PP+ N SQ G PP + +PP
Sbjct: 93 ------------PPHPGKPERPPPQGGNQSQ-------GTPPPPGKPERPPPQGGNQSHR 133
Query: 298 PSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPA 357
P P P + ER P + S E ++R+ R P
Sbjct: 134 PPPPPGKP------------ERPPPQGGNQSQGPPPHPGKPEGPPPQEG-NKSRSARSPP 180
Query: 358 RGSSGEKENRGGRRAVRPGSGGPLLSWPLG--PAPPPRPPQLERHVVRPPPRSPEP 411
G + G + P G P P G P P PP + PPP+ P
Sbjct: 181 GKPQGPPQQEGNKPQGPPPPGKPQGPPPAGGNPQQPQAPPAGKPQGPPPPPQGGRP 236
Score = 49.3 bits (116), Expect = 1e-05
Identities = 49/167 (29%), Positives = 65/167 (38%), Gaps = 25/167 (14%)
Query: 151 EGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGP----LPAGPPPE 206
EGR + G P R G+ G ++ PP PP P + P GPPP
Sbjct: 37 EGRRPQ-GGNQPQRPPPPPGKPQGPPPQGGNQSQGPPPPPGKPEGRPPQGGNQSQGPPPH 95
Query: 207 DVPGPPKRKEREAGNE----PPTPRKKVKGGRERHLKKVGGDACLLRGSDPGGPGLLPPR 262
PG P+R + GN+ PP P G+ GG+ PG P PP+
Sbjct: 96 --PGKPERPPPQGGNQSQGTPPPP------GKPERPPPQGGNQSHRPPPPPGKPERPPPQ 147
Query: 263 VLNPSQAFSSCHPGL----PPENWEKPKPPLASAEGPAVPSPSPQRE 305
N SQ HPG PP+ K + ++ P P PQ+E
Sbjct: 148 GGNQSQG-PPPHPGKPEGPPPQEGNKSR---SARSPPGKPQGPPQQE 190
Score = 43.9 bits (102), Expect = 5e-04
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 15/82 (18%)
Query: 150 QEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVP 209
QEG S+ + PG+ + +EG +P PPPP + +GP PAG P+
Sbjct: 168 QEGNKSRSARSPPGKPQGPPQQEG----------NKPQGPPPPGKPQGPPPAGGNPQQPQ 217
Query: 210 GPPKRKER-----EAGNEPPTP 226
PP K + G PP P
Sbjct: 218 APPAGKPQGPPPPPQGGRPPRP 239
Score = 33.5 bits (75), Expect = 0.68
Identities = 25/92 (27%), Positives = 36/92 (39%), Gaps = 10/92 (10%)
Query: 150 QEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVP 209
Q G S+ PG+ +EG S +P PP ++G P GPPP P
Sbjct: 147 QGGNQSQGPPPHPGKPEGPPPQEGNKSRSARSPPGKPQGPPQ---QEGNKPQGPPPPGKP 203
Query: 210 -------GPPKRKEREAGNEPPTPRKKVKGGR 234
G P++ + +P P +GGR
Sbjct: 204 QGPPPAGGNPQQPQAPPAGKPQGPPPPPQGGR 235
Score = 31.6 bits (70), Expect = 2.6
Identities = 26/92 (28%), Positives = 34/92 (36%), Gaps = 4/92 (4%)
Query: 338 GTSLSEDEAPGEARNGRRPARG---SSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPR- 393
G + S+ P + RP +G S G + G P G P P P R
Sbjct: 64 GGNQSQGPPPPPGKPEGRPPQGGNQSQGPPPHPGKPERPPPQGGNQSQGTPPPPGKPERP 123
Query: 394 PPQLERHVVRPPPRSPEPDTLPLAAGSDHPLP 425
PPQ RPPP +P+ P G+ P
Sbjct: 124 PPQGGNQSHRPPPPPGKPERPPPQGGNQSQGP 155
>gi|31324577 molecule interacting with Rab13 [Homo sapiens]
Length = 863
Score = 52.8 bits (125), Expect = 1e-06
Identities = 77/339 (22%), Positives = 115/339 (33%), Gaps = 50/339 (14%)
Query: 114 CTICNEIVHPGCLKMGKAEGVI--------------NAEIPNCWECPRCTQEGRTSKDSG 159
C C+ + PG + G EG + P + P+ + + ++D+
Sbjct: 191 CRRCSSTLLPGAYENGPEEGTFVCAEHCARLGPGTRSGTRPGPFSQPKQQHQQQLAEDAK 250
Query: 160 EGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPA-GPPPEDVPGPPKRKERE 218
+ PG + + GA E P P PR G L PP P P RK E
Sbjct: 251 DVPGGGPSSSAPAGAEADGPKASPEARPQIPTKPRVPGKLQELASPPAGRPTPAPRKASE 310
Query: 219 AGN-EPPTPRKKVKGGRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGL 277
+ PPTPR + ++ +L + G + L+ G P P PS+ G
Sbjct: 311 STTPAPPTPRPR-SSLQQENLVEQAGSSSLVNGRLHELPVPKPRGTPKPSE-------GT 362
Query: 278 PPENWEKPKPPLASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSS 337
P + P L AE P+P P P +S DS +
Sbjct: 363 PAPRKDPPWITLVQAEPKKKPAPLP------------------PSSSPGPPSQDSRQVEN 404
Query: 338 GTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPG-SGGPLLSWP------LGPAP 390
G + + A +P E+E++ P + P L P L P
Sbjct: 405 GGTEEVAQPSPTASLESKPYNPFEEEEEDKEEEAPAAPSLATSPALGHPESTPKSLHPWY 464
Query: 391 PPRPPQLERHVVRPPPRSPEPDTLPL-AAGSDHPLPRAA 428
P + RP PR+P L L A+ H P +A
Sbjct: 465 GITPTSSPKTKKRPAPRAPSASPLALHASRLSHSEPPSA 503
>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
sapiens]
Length = 505
Score = 52.4 bits (124), Expect = 1e-06
Identities = 45/150 (30%), Positives = 53/150 (35%), Gaps = 1/150 (0%)
Query: 186 PPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTP-RKKVKGGRERHLKKVGGD 244
PP PPPPP GP P P PP + A PP P R V +
Sbjct: 287 PPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPP 346
Query: 245 ACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSPSPQR 304
L S P GP PP VL P PP P P L S VP+ + +
Sbjct: 347 PPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNK 406
Query: 305 EKLERFKRMCQLLERVPDTSSSSSDSDSDS 334
L R L++V S S S D+
Sbjct: 407 AALLDQIREGAQLKKVEQNSRPVSCSGRDA 436
Score = 36.2 bits (82), Expect = 0.11
Identities = 39/138 (28%), Positives = 53/138 (38%), Gaps = 11/138 (7%)
Query: 306 KLERFKRMCQLLE-RVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEK 364
+L+ MC + E ++ D +S D + G ++E +A P+RG
Sbjct: 231 ELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPP 290
Query: 365 ----ENRGGRRAVRPGSGGPLLSWPLGP--APPPRPPQLERHVVRPPPRS----PEPDTL 414
N G G G P P APPP PP V PPP + P P L
Sbjct: 291 PPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPAL 350
Query: 415 PLAAGSDHPLPRAAWLRV 432
P +A S P P + L V
Sbjct: 351 PSSAPSGPPPPPPSVLGV 368
Score = 34.7 bits (78), Expect = 0.31
Identities = 18/44 (40%), Positives = 21/44 (47%), Gaps = 10/44 (22%)
Query: 385 PLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAA 428
P+ P PPP PP PPP P P LP + DH +P A
Sbjct: 370 PVAPPPPPPPP--------PPPGPPPPPGLP--SDGDHQVPTTA 403
>gi|21464119 methyl-CpG binding domain protein 1 isoform PCM1 [Homo
sapiens]
Length = 556
Score = 52.4 bits (124), Expect = 1e-06
Identities = 22/46 (47%), Positives = 28/46 (60%), Gaps = 1/46 (2%)
Query: 33 RRRRTRCRRCRACVRT-ECGDCHFCRDMKKFGGPGRMKQSCLLRQC 77
RR+ +C C AC+R +CG C FC D KFGG + +Q C RQC
Sbjct: 283 RRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQC 328
Score = 31.2 bits (69), Expect = 3.4
Identities = 25/79 (31%), Positives = 31/79 (39%), Gaps = 8/79 (10%)
Query: 141 NCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLG---SGWKLTEEP---PLPPPPPR 194
+C CP C + R +RR G+ G S P PLPPPPP
Sbjct: 187 DCGHCPICLRPPRPGLRRQWKCVQRRCLRGKHARRKGGCDSKMAARRRPGAQPLPPPPP- 245
Query: 195 RKGPLPAGPPPEDV-PGPP 212
+ P P P P + P PP
Sbjct: 246 SQSPEPTEPHPRALAPSPP 264
>gi|21464117 methyl-CpG binding domain protein 1 isoform 1 [Homo
sapiens]
Length = 605
Score = 52.4 bits (124), Expect = 1e-06
Identities = 22/46 (47%), Positives = 28/46 (60%), Gaps = 1/46 (2%)
Query: 33 RRRRTRCRRCRACVRT-ECGDCHFCRDMKKFGGPGRMKQSCLLRQC 77
RR+ +C C AC+R +CG C FC D KFGG + +Q C RQC
Sbjct: 332 RRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQC 377
Score = 41.6 bits (96), Expect = 0.003
Identities = 53/207 (25%), Positives = 71/207 (34%), Gaps = 50/207 (24%)
Query: 24 SSRGPGAGARRRRTRCRRCRA-----------CVRTECGDCHFCRDMKKFGGPGRMKQSC 72
S G G +R +T C+ CRA R CG+C C+ + G +C
Sbjct: 139 SFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECAACQVTEDCGACS----TC 194
Query: 73 LLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAE 132
LL+ LPH L + + + E G C +C GC
Sbjct: 195 LLQ------LPHDVASGLFCKCERRRCLRIVERSRG-----CGVCR-----GCQTQ---- 234
Query: 133 GVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLG---SGWKLTEEP--- 186
+C CP C + R +RR G+ G S P
Sbjct: 235 -------EDCGHCPICLRPPRPGLRRQWKCVQRRCLRGKHARRKGGCDSKMAARRRPGAQ 287
Query: 187 PLPPPPPRRKGPLPAGPPPEDV-PGPP 212
PLPPPPP + P P P P + P PP
Sbjct: 288 PLPPPPP-SQSPEPTEPHPRALAPSPP 313
>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
Length = 416
Score = 52.4 bits (124), Expect = 1e-06
Identities = 68/266 (25%), Positives = 90/266 (33%), Gaps = 40/266 (15%)
Query: 179 GWKLTEEPPLPPP----PPRRKGPLPAGPPPEDVPGPPKRKEREAGNEP--PTPRKKVKG 232
G + PP PP PP + G P GPPP PG P+ + GN+P P P K +G
Sbjct: 43 GGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPP--PGKPQGPPPQGGNKPQGPPPPGKPQG 100
Query: 233 GRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFS---SCHPGLPPENWEKPK--P 287
+ GD S PG P PP+ N Q G PP+ KP+ P
Sbjct: 101 PPPQ------GDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPP 154
Query: 288 PLASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDS---------DSDSDSSG 338
P +GP PQ + R R + P + G
Sbjct: 155 PPGKPQGPP-----PQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGG 209
Query: 339 TSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAP----PPRP 394
PG+ + S + G+ P GG + P GP P P P
Sbjct: 210 NKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGG---NQPQGPPPPPGKPQGP 266
Query: 395 PQLERHVVRPPPRSPEPDTLPLAAGS 420
P + + PP +P P GS
Sbjct: 267 PPQGGNKPQGPPPPGKPQGPPPQGGS 292
Score = 50.1 bits (118), Expect = 7e-06
Identities = 66/257 (25%), Positives = 91/257 (35%), Gaps = 39/257 (15%)
Query: 186 PPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEP--PTPRKKVKGGRERHLKKVGG 243
P P PP + G P GPPP PG P+ + GN+P P P K +G + G
Sbjct: 115 PGKPQGPPPQGGNQPQGPPPP--PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQ-----GD 167
Query: 244 DACLLRGSDPGGPGLLPPRVLNPSQAFS---SCHPGLPPENWEKPK--PPLASAEGPAVP 298
+ S PG P PP+ N Q G PP+ KP+ PP +GP
Sbjct: 168 NKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPP-- 225
Query: 299 SPSPQREKLERFKRMCQLLERVPDTSSSSSDS---------DSDSDSSGTSLSEDEAPGE 349
PQ + + R + P + G PG+
Sbjct: 226 ---PQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGK 282
Query: 350 ARNGRRPARGSSGEKENRG--GRRAVRPGSGGPLLSWPLGPAP----PPRPPQLERHVVR 403
+ P +G S + +R G+ P GG + P GP P P PP + +
Sbjct: 283 PQGP--PPQGGSKSRSSRSPPGKPQGPPPQGG---NQPQGPPPPPGKPQGPPPQGGNKPQ 337
Query: 404 PPPRSPEPDTLPLAAGS 420
PP +P P GS
Sbjct: 338 GPPPPGKPQGPPPQGGS 354
Score = 49.3 bits (116), Expect = 1e-05
Identities = 67/271 (24%), Positives = 91/271 (33%), Gaps = 58/271 (21%)
Query: 166 RADNGEEGASLGSGWKLTEEPPLPPP----PPRRKGPLPAGPPPEDVP-GPPKR---KER 217
R+ G+ G + PP PP PP + G P GPPP P GPP + K R
Sbjct: 112 RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSR 171
Query: 218 EAGNEPPTPRKKVKGGRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGL 277
+ + P P+ G G+ P GP PP P G
Sbjct: 172 SSRSPPGKPQGPPPQG----------------GNQPQGP---PPPPGKPQ--------GP 204
Query: 278 PPENWEKPK--PPLASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDS----- 330
PP+ KP+ PP +G P PQ + + R + P +
Sbjct: 205 PPQGGNKPQGPPPPGKPQG-----PPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPP 259
Query: 331 ----DSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRG--GRRAVRPGSGGPLLSW 384
G PG+ + P +G S + +R G+ P GG +
Sbjct: 260 PGKPQGPPPQGGNKPQGPPPPGKPQG--PPPQGGSKSRSSRSPPGKPQGPPPQGG---NQ 314
Query: 385 PLGPAPPPRPPQLERHVVRPPPRSPEPDTLP 415
P GP PPP PQ P+ P P P
Sbjct: 315 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKP 345
Score = 46.6 bits (109), Expect = 8e-05
Identities = 62/268 (23%), Positives = 85/268 (31%), Gaps = 56/268 (20%)
Query: 152 GRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPP-RRKGPLPAG-------P 203
G+ +G + R+ G G + +P PPPPP + +GP P G P
Sbjct: 157 GKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPP 216
Query: 204 PPEDVPGPPKR---KEREAGNEPPTPRKKVKGGRERHLKKVGGDACLLRGSDPGGPGLLP 260
PP GPP + K + A + P P+ G G+ P GP P
Sbjct: 217 PPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQG----------------GNQPQGP---P 257
Query: 261 PRVLNPSQAFSSCHPGLPPENWEKPK--PPLASAEGPAVPSPSPQREKLERFKRMCQLLE 318
P P G PP+ KP+ PP +GP S R
Sbjct: 258 PPPGKPQ--------GPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRS------------S 297
Query: 319 RVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSG 378
R P + G + G G +G + +G P G
Sbjct: 298 RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG----PPPQGG 353
Query: 379 GPLLSWPLGPAPPPRPPQLERHVVRPPP 406
S P P PPQ E + + PP
Sbjct: 354 SKSRSARSPPGKPQGPPQQEGNNPQGPP 381
Score = 39.7 bits (91), Expect = 0.010
Identities = 40/131 (30%), Positives = 49/131 (37%), Gaps = 21/131 (16%)
Query: 177 GSGWKLTEEPP-LPPPPPRRKGPLPAGPPPED--VPGPPKRKEREAGNEP--PTPRKKVK 231
GS + + PP P PP + G P GPPP GPP + GN+P P P K +
Sbjct: 291 GSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP----QGGNKPQGPPPPGKPQ 346
Query: 232 GGRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLAS 291
G + GG S PG P P Q + G PP P+ P A
Sbjct: 347 GPPPQ-----GGSKSRSARSPPGKP-------QGPPQQEGNNPQGPPPPAGGNPQQPQAP 394
Query: 292 AEGPAVPSPSP 302
G P P
Sbjct: 395 PAGQPQGPPRP 405
Score = 37.0 bits (84), Expect = 0.062
Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 2/59 (3%)
Query: 177 GSGWKLTEEPP-LPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGR 234
GS + PP P PP+++G P GPPP G P++ + +P P + +GGR
Sbjct: 353 GSKSRSARSPPGKPQGPPQQEGNNPQGPPP-PAGGNPQQPQAPPAGQPQGPPRPPQGGR 410
Score = 36.2 bits (82), Expect = 0.11
Identities = 39/153 (25%), Positives = 56/153 (36%), Gaps = 34/153 (22%)
Query: 152 GRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRR-KGPLPAG-------- 202
G+ +G + R+ G G + +P PPPPP + +GP P G
Sbjct: 281 GKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPP 340
Query: 203 PPPEDVPGPPK--RKEREAGNEPPTPRKKVKGGRERHLKKVGGDACLLRGSDPGGPGLLP 260
PP + PP+ K R A + P P+ + G++P GP P
Sbjct: 341 PPGKPQGPPPQGGSKSRSARSPPGKPQGPPQ----------------QEGNNPQGPP--P 382
Query: 261 PRVLNPSQ-----AFSSCHPGLPPENWEKPKPP 288
P NP Q A P PP+ +PP
Sbjct: 383 PAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPP 415
Score = 33.1 bits (74), Expect = 0.89
Identities = 20/75 (26%), Positives = 28/75 (37%), Gaps = 10/75 (13%)
Query: 150 QEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVP 209
Q G S+ + PG+ + +EG P PPPP P PP
Sbjct: 351 QGGSKSRSARSPPGKPQGPPQQEG----------NNPQGPPPPAGGNPQQPQAPPAGQPQ 400
Query: 210 GPPKRKEREAGNEPP 224
GPP+ + + PP
Sbjct: 401 GPPRPPQGGRPSRPP 415
>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
Length = 1682
Score = 52.0 bits (123), Expect = 2e-06
Identities = 65/236 (27%), Positives = 93/236 (39%), Gaps = 56/236 (23%)
Query: 186 PPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKG------GRERHLK 239
P LPPPPP K P P+ P P P PP PP+P +K G++ +
Sbjct: 773 PALPPPPPLAKFPPPSQPQP---PPPP----------PPSPASLLKSLASVLEGQKYCYR 819
Query: 240 KVGGDACLLRG---------SDPGGPGLLPPRVLNPS-------QAFSSCHPGLPPENW- 282
G G P G LPP PS A SS W
Sbjct: 820 GTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSAAPSAQGSPQPSASSSSQFSTSGGPWA 879
Query: 283 ------EKPKP-PLASAEGP---AVPSPSPQREKLERFKRMCQ-LLERVPDTSSSSSD-- 329
E+P P P+ + P ++P + E LE R C+ L+ERV +++ +D
Sbjct: 880 RERRAGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEISRACETLVERVGRSATDPADPV 939
Query: 330 SDSDSDSSGT------SLSEDEAPGEAR-NGRRPARGSSGEKENRGGRRAVRPGSG 378
++ SGT + +++EA G A +G R +KE+R RRA + G
Sbjct: 940 DTAEPADSGTERLLPPAQAKEEAGGVAAVSGSCKRRQKEHQKEHRRHRRACKDSVG 995
Score = 50.8 bits (120), Expect = 4e-06
Identities = 82/303 (27%), Positives = 109/303 (35%), Gaps = 55/303 (18%)
Query: 137 AEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRK 196
AE P P G + ++ G+RR E L G L P PPPP
Sbjct: 201 AEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPLPPPPLPPPPP---- 256
Query: 197 GPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKKVGGDACLLRGSDP--- 253
P PPP +PG PP K H G + +GS P
Sbjct: 257 ---PPPPPPPPLPG--------LATSPPFQLTKPGLWSTLHGDAWGPER---KGSAPPER 302
Query: 254 -GGPGLLPPRVLNPSQAFSSCHPG------LPPENWEKPKPPLASAEG--PAV-PSPSPQ 303
LP P+ A+++ PG PP P+PP A + G PA P S
Sbjct: 303 QEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAPP--GPGPRPPGAESHGCLPATRPPGSDL 360
Query: 304 REKLERFKRMCQLLERVPDTS------------SSSSDSDSDSDSSGTSLSEDEA-PG-- 348
RE + RM + T+ ++ S S S SS T L E PG
Sbjct: 361 RESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIP 420
Query: 349 EARNGRRPA-----RGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVR 403
A + + PA G G + + + + P LS P GP+ PP PP ++R
Sbjct: 421 GADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPC--PRLLR 478
Query: 404 PPP 406
PPP
Sbjct: 479 PPP 481
Score = 37.0 bits (84), Expect = 0.062
Identities = 62/245 (25%), Positives = 76/245 (31%), Gaps = 59/245 (24%)
Query: 186 PPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAG----------NEPPTPRKKVKGGRE 235
P PPPPP + P PPP + GP R RE G PP P RE
Sbjct: 465 PSSPPPPPCPRLLRPP-PPPAWLKGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHRE 523
Query: 236 RHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPP-LASAEG 294
L + D P P + S + S H P P PP LA +
Sbjct: 524 GFLGP-PASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSID 582
Query: 295 PAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGR 354
P PSP + + + L +P
Sbjct: 583 PLPRPPSPAQNPQD--PPLVPLTLALP--------------------------------- 607
Query: 355 RPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTL 414
PA SS + G R RP S P +S+P P P PP P P S P +
Sbjct: 608 -PAPPSSCHQNTSGSFR--RPESPRPRVSFPKTPEVGPGPP--------PGPLSKAPQPV 656
Query: 415 PLAAG 419
P G
Sbjct: 657 PPGVG 661
Score = 37.0 bits (84), Expect = 0.062
Identities = 42/148 (28%), Positives = 51/148 (34%), Gaps = 22/148 (14%)
Query: 160 EGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRK---E 216
+GP R A E+G L + TE PP P PPP P E GPP +
Sbjct: 487 KGPACRAAR--EDGEILEELFFGTEGPPRPAPPPL--------PHREGFLGPPASRFSVG 536
Query: 217 REAGNEPPTPRKKVKGGRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPG 276
+ + PPTP + S P GP PP P
Sbjct: 537 TQDSHTPPTPPTPTTSSSNSNSGS--------HSSSPAGPVSFPPPPYLARSIDPLPRPP 588
Query: 277 LPPEN-WEKPKPPLASAEGPAVPSPSPQ 303
P +N + P PL A PA PS Q
Sbjct: 589 SPAQNPQDPPLVPLTLALPPAPPSSCHQ 616
Score = 35.8 bits (81), Expect = 0.14
Identities = 39/152 (25%), Positives = 52/152 (34%), Gaps = 33/152 (21%)
Query: 275 PGLPPENWEKPKPPLASAEGPAVPSPSPQREKLERFKRMCQLLER--------------- 319
P LPP PP + + P P PSP K + +LE
Sbjct: 773 PALPPPPPLAKFPPPSQPQPPPPPPPSPA----SLLKSLASVLEGQKYCYRGTGAAVSTR 828
Query: 320 ---VPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPG 376
+P T S S T+L A A+ +P+ SS + GG A
Sbjct: 829 PGPLPTTQYSPGPP-----SGATALPPTSAAPSAQGSPQPSASSSSQFSTSGGPWARERR 883
Query: 377 SGGPLLSWPLGPAPPPRPPQLERHVVRPPPRS 408
+G + P+ P PP P L PP RS
Sbjct: 884 AGEEPVPGPMTPTQPPPPLSL------PPARS 909
Score = 29.6 bits (65), Expect = 9.8
Identities = 22/73 (30%), Positives = 27/73 (36%), Gaps = 9/73 (12%)
Query: 152 GRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGP 211
G S E GR ++ GAS +PP P PP P P+ P
Sbjct: 1019 GNLDLQSEEIQGREKSRPDLGGASKA-------KPPTAPAPP--SAPAPSAQPTPPSASV 1069
Query: 212 PKRKEREAGNEPP 224
P +K RE PP
Sbjct: 1070 PGKKAREEAPGPP 1082
>gi|190194416 F-box and leucine-rich repeat protein 15 [Homo
sapiens]
Length = 300
Score = 52.0 bits (123), Expect = 2e-06
Identities = 65/231 (28%), Positives = 92/231 (39%), Gaps = 40/231 (17%)
Query: 424 LPRAAWLRVFQHL-GPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVR 482
+PRAA R+ + G +EL + C W D+ L P L+R L L G +
Sbjct: 74 IPRAALARLLRDAEGLQELALAP--CH---EWLSDEDLVPV--LARNPQLRSVALGGCGQ 126
Query: 483 RQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAP--LPALRLLDLR 540
RAL G + LQ L L+ C W+ AL PAL LDL
Sbjct: 127 LSRRALGALAEGCPR------------LQRLSLAHCDWVDGLALRGLADRCPALEELDLT 174
Query: 541 WIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLA-GLELTDASLRLLLRHAPQL 599
+KD + L ++ R G+ L LA + DA+++ L R+ P+L
Sbjct: 175 ACRQLKDEAIVYL-------------AQRRGAGLRSLSLAVNANVGDAAVQELARNCPEL 221
Query: 600 SALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRR 650
LDL+ C VG V L LR L + CH + + L R+
Sbjct: 222 HHLDLTGCLRVGSDGVRTLAEYCPVLRS----LRVRHCHHVAESSLSRLRK 268
Score = 52.0 bits (123), Expect = 2e-06
Identities = 58/188 (30%), Positives = 82/188 (43%), Gaps = 23/188 (12%)
Query: 495 VSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAP--LPALRLLDLRWIEDVKDSQLRE 552
+S + L+ +L R L+ + L GC LS ALG+ P L+ L L + V LR
Sbjct: 101 LSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRG 160
Query: 553 LLLPPPDTKPGQTESRGRLQGVAELRLAGL-ELTD-ASLRLLLRHAPQLSALDLSHCAHV 610
L R + EL L +L D A + L R L +L L+ A+V
Sbjct: 161 LA--------------DRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANV 206
Query: 611 GDPSVHLLTAPTSPLRETLVHLNLAGCHRL-TDHCLPLFRRCPRLRRLDLRSCRQLSPEA 669
GD +V L L HL+L GC R+ +D L CP LR L +R C ++ +
Sbjct: 207 GDAAVQELARNCPELH----HLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESS 262
Query: 670 CARLAAAG 677
+RL G
Sbjct: 263 LSRLRKRG 270
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/210 (30%), Positives = 86/210 (40%), Gaps = 29/210 (13%)
Query: 472 LTPPMLSGVVRRQP---RALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGS 528
+ PPM ++P R LDL W V L +LNR+ Q L L S + +L
Sbjct: 1 MEPPMEPSGGEQEPGAVRFLDLPWEDVL---LPHVLNRVPLRQLLRLQRVS-RAFRSLVQ 56
Query: 529 APLPALRLLDLRWI-EDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLE--LT 585
L LR D + + + L LL +G+ EL LA L+
Sbjct: 57 LHLAGLRRFDAAQVGPQIPRAALARLLRDA--------------EGLQELALAPCHEWLS 102
Query: 586 DASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCL 645
D L +L PQL ++ L C + ++ L L+ L+LA C + L
Sbjct: 103 DEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQR----LSLAHCDWVDGLAL 158
Query: 646 P-LFRRCPRLRRLDLRSCRQLSPEACARLA 674
L RCP L LDL +CRQL EA LA
Sbjct: 159 RGLADRCPALEELDLTACRQLKDEAIVYLA 188
Score = 44.7 bits (104), Expect = 3e-04
Identities = 64/206 (31%), Positives = 87/206 (42%), Gaps = 36/206 (17%)
Query: 486 RALDLSWTG--VSKKQLMWLLNRLQGLQELVLSGC-SWLSVSALGSAPLPALRLLDLRWI 542
R D + G + + L LL +GLQEL L+ C WLS L +P L
Sbjct: 63 RRFDAAQVGPQIPRAALARLLRDAEGLQELALAPCHEWLSDEDL----VPVL-------- 110
Query: 543 EDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAE-------LRLAGLELTDA-SLRLLLR 594
++ QLR + L GQ SR L +AE L LA + D +LR L
Sbjct: 111 --ARNPQLRSVALGGC----GQL-SRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLAD 163
Query: 595 HAPQLSALDLSHCAHVGDPS-VHLLTAPTSPLRETLVHLNLAGCHRLTDHCLP-LFRRCP 652
P L LDL+ C + D + V+L + LR L+LA + D + L R CP
Sbjct: 164 RCPALEELDLTACRQLKDEAIVYLAQRRGAGLRS----LSLAVNANVGDAAVQELARNCP 219
Query: 653 RLRRLDLRSCRQLSPEACARLAAAGP 678
L LDL C ++ + LA P
Sbjct: 220 ELHHLDLTGCLRVGSDGVRTLAEYCP 245
Score = 36.2 bits (82), Expect = 0.11
Identities = 50/154 (32%), Positives = 63/154 (40%), Gaps = 37/154 (24%)
Query: 533 ALRLLDLRWIEDV------KDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTD 586
A+R LDL W EDV LR+LL Q SR + + +L LAGL D
Sbjct: 16 AVRFLDLPW-EDVLLPHVLNRVPLRQLLRL-------QRVSRA-FRSLVQLHLAGLRRFD 66
Query: 587 ASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHR-LTDHCL 645
A+ + PQ+ L+ E L L LA CH L+D L
Sbjct: 67 AA-----QVGPQIPRAALARLLRDA---------------EGLQELALAPCHEWLSDEDL 106
Query: 646 -PLFRRCPRLRRLDLRSCRQLSPEACARLAAAGP 678
P+ R P+LR + L C QLS A LA P
Sbjct: 107 VPVLARNPQLRSVALGGCGQLSRRALGALAEGCP 140
>gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2
[Homo sapiens]
Length = 690
Score = 51.6 bits (122), Expect = 2e-06
Identities = 52/221 (23%), Positives = 93/221 (42%), Gaps = 43/221 (19%)
Query: 424 LPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPP--MLSGVV 481
LP A L++F +L +++ IC +V W LW +D S K++ P ++S +
Sbjct: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 217
Query: 482 RRQPRALDLSWTG-VSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLR 540
R + L L++ G + + + ++ + LQEL +S C +
Sbjct: 218 RWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFT------------------ 259
Query: 541 WIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLS 600
D +R + S G GV L L+ +T+ ++RLL RH L
Sbjct: 260 ------DESMRHI-------------SEG-CPGVLCLNLSNTTITNRTMRLLPRHFHNLQ 299
Query: 601 ALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLT 641
L L++C D + L L++L+L+GC +++
Sbjct: 300 NLSLAYCRRFTDKGLQYLNLGNG--CHKLIYLDLSGCTQIS 338
Score = 48.1 bits (113), Expect = 3e-05
Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 8/98 (8%)
Query: 584 LTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDH 643
+TDAS + + ++ P LS + ++ C + D S+ L SPL++ V LNLA C R+ D
Sbjct: 413 VTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSL----SPLKQLTV-LNLANCVRIGDM 467
Query: 644 CLPLFRRCP---RLRRLDLRSCRQLSPEACARLAAAGP 678
L F P R+R L+L +C +LS + +L+ P
Sbjct: 468 GLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCP 505
Score = 40.0 bits (92), Expect = 0.007
Identities = 38/161 (23%), Positives = 75/161 (46%), Gaps = 20/161 (12%)
Query: 510 LQELVLSGCSWLSVSALGS-APLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESR 568
L + ++ C ++ S+L S +PL L +L+L + D L++ L P +
Sbjct: 428 LSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR------- 480
Query: 569 GRLQGVAELRLAG-LELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRE 627
+ EL L+ + L+DAS+ L P L+ L L +C H+ + + S
Sbjct: 481 -----IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFS---- 531
Query: 628 TLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPE 668
LV ++L+G +++ L + R +L+ L + C +++ +
Sbjct: 532 -LVSIDLSGTD-ISNEGLNVLSRHKKLKELSVSECYRITDD 570
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.137 0.443
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,198,175
Number of Sequences: 37866
Number of extensions: 2881661
Number of successful extensions: 35733
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 377
Number of HSP's successfully gapped in prelim test: 1340
Number of HSP's that attempted gapping in prelim test: 19004
Number of HSP's gapped (non-prelim): 11990
length of query: 694
length of database: 18,247,518
effective HSP length: 109
effective length of query: 585
effective length of database: 14,120,124
effective search space: 8260272540
effective search space used: 8260272540
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.