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Search of human proteins with 11055998
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
(340 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 702 0.0
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 649 0.0
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 647 0.0
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 588 e-168
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 372 e-103
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 372 e-103
gi|32189425 WD repeat domain 69 [Homo sapiens] 122 6e-28
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 121 1e-27
gi|23199987 WD repeat domain 5B [Homo sapiens] 113 3e-25
gi|16554629 WD repeat domain 5 [Homo sapiens] 111 8e-25
gi|16554627 WD repeat domain 5 [Homo sapiens] 111 8e-25
gi|113865883 WD repeat domain 38 [Homo sapiens] 111 1e-24
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 111 1e-24
gi|21071067 TBP-associated factor 5 [Homo sapiens] 107 2e-23
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 107 2e-23
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 104 1e-22
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 104 1e-22
gi|26665869 WD repeat domain 51B [Homo sapiens] 102 6e-22
gi|13376840 WD repeat domain 61 [Homo sapiens] 100 2e-21
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 99 7e-21
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 99 7e-21
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 99 7e-21
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 99 7e-21
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 96 5e-20
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 94 2e-19
gi|19913367 transducin beta-like 1Y [Homo sapiens] 94 2e-19
gi|19913365 transducin beta-like 1Y [Homo sapiens] 94 2e-19
gi|15150805 transducin beta-like 1Y [Homo sapiens] 94 2e-19
gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens] 93 3e-19
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 93 4e-19
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 702 bits (1811), Expect = 0.0
Identities = 340/340 (100%), Positives = 340/340 (100%)
Query: 1 MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYA 60
MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYA
Sbjct: 1 MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYA 60
Query: 61 MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120
MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
Sbjct: 61 MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120
Query: 121 CSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTF 180
CSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTF
Sbjct: 121 CSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTF 180
Query: 181 TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA 240
TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA
Sbjct: 181 TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA 240
Query: 241 FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTL 300
FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTL
Sbjct: 241 FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTL 300
Query: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN
Sbjct: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 649 bits (1673), Expect = 0.0
Identities = 309/340 (90%), Positives = 326/340 (95%)
Query: 1 MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYA 60
MSEL+QLRQEAEQL+NQI+DARKAC DATL QIT+N+D VGRIQMRTRRTLRGHLAKIYA
Sbjct: 1 MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA 60
Query: 61 MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120
MHWG DSRLLVSASQDGKLIIWDSYTTNK+HAIPLRSSWVMTCAYAPSGNYVACGGLDNI
Sbjct: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120
Query: 121 CSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTF 180
CSIYNLKTREGNVRVSREL GHTGYLSCCRFLDD+QIVTSSGDTTCALWDIET QQTTTF
Sbjct: 121 CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF 180
Query: 181 TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA 240
TGH+GDVMSLSL+PD R FVSGACDAS+KLWD+R+GMCRQ+FTGH SDINA+ FFPNG A
Sbjct: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240
Query: 241 FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTL 300
FATGSDDATCRLFDLRADQEL+ YSHDNIICGITSV+FSKSGRLLLAGYDDFNCNVWD L
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
K DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFL+IWN
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 647 bits (1668), Expect = 0.0
Identities = 306/340 (90%), Positives = 324/340 (95%)
Query: 1 MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYA 60
MSELEQLRQEAEQLRNQI+DARKAC D+TL QIT+ +D VGRIQMRTRRTLRGHLAKIYA
Sbjct: 1 MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYA 60
Query: 61 MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120
MHWG DSRLLVSASQDGKLIIWDSYTTNK+HAIPLRSSWVMTCAYAPSGN+VACGGLDNI
Sbjct: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNI 120
Query: 121 CSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTF 180
CSIY+LKTREGNVRVSRELPGHTGYLSCCRFLDD+QI+TSSGDTTCALWDIET QQT F
Sbjct: 121 CSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGF 180
Query: 181 TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA 240
GHSGDVMSLSL+PD RTFVSGACDAS KLWD+RD MCRQ+F GH SDINAV+FFPNGYA
Sbjct: 181 AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA 240
Query: 241 FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTL 300
F TGSDDATCRLFDLRADQELL+YSHDNIICGITSVAFS+SGRLLLAGYDDFNCN+WD +
Sbjct: 241 FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAM 300
Query: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFL+IWN
Sbjct: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 588 bits (1516), Expect = e-168
Identities = 271/340 (79%), Positives = 306/340 (90%)
Query: 1 MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYA 60
M E+EQLRQEAEQL+ QI DARKAC D TL ++ S ++ VGR+QMRTRRTLRGHLAKIYA
Sbjct: 1 MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYA 60
Query: 61 MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120
MHW DS+LLVSASQDGKLI+WDSYTTNK+HAIPLRSSWVMTCAYAPSGN+VACGGLDN+
Sbjct: 61 MHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNM 120
Query: 121 CSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTF 180
CSIYNLK+REGNV+VSREL HTGYLSCCRFLDD+ IVTSSGDTTCALWDIET QQ T F
Sbjct: 121 CSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVF 180
Query: 181 TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA 240
GH+GD MSL++SPD F+SGACDAS+KLWD+R+G CRQ+FTGH SDINA+ FFPNG A
Sbjct: 181 VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA 240
Query: 241 FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTL 300
TGSDDA+CRLFDLRADQEL+ +SH++IICGITSVAFS SGRLL AGYDDFNCNVWD++
Sbjct: 241 ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM 300
Query: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
K +R G+L+GHDNRVSCLGVT DGMAVATGSWDSFL+IWN
Sbjct: 301 KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 372 bits (955), Expect = e-103
Identities = 178/341 (52%), Positives = 237/341 (69%), Gaps = 5/341 (1%)
Query: 4 LEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYAMHW 63
L L+ EAE L+ ++++ R +D L Q+ ++++G+ M+TRRTL+GH K+ M W
Sbjct: 12 LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 71
Query: 64 GYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 123
D R +VS+SQDGK+I+WDS+TTNK HA+ + +WVM CAYAPSG +ACGGLDN CS+
Sbjct: 72 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 131
Query: 124 YNLK--TREGNVRVSRELPGHTGYLSCCRFLD-DSQIVTSSGDTTCALWDIETAQQTTTF 180
Y L E + + HT YLS C F + D QI+T+SGD TCALWD+E+ Q +F
Sbjct: 132 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 191
Query: 181 TGHSGDVMSLSLSPDM--RTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNG 238
GH DV+ L L+P TFVSG CD + +WD+R G C Q+F H SDIN+V ++P+G
Sbjct: 192 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 251
Query: 239 YAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWD 298
AFA+GSDDATCRL+DLRAD+E+ +YS ++II G +SV FS SGRLL AGY+D+ NVWD
Sbjct: 252 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 311
Query: 299 TLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
LKG R +L GH+NRVS L V+ DG A +GSWD LR+W
Sbjct: 312 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 66.6 bits (161), Expect = 3e-11
Identities = 53/215 (24%), Positives = 92/215 (42%), Gaps = 7/215 (3%)
Query: 133 VRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLS 191
++ R L GH + C + D + IV+SS D +WD T + T VM+ +
Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 112
Query: 192 LSPDMRTFVSGACDASSKLW----DIRDGMC--RQSFTGHVSDINAVSFFPNGYAFATGS 245
+P G D ++ D + M ++S H + ++A SF + T S
Sbjct: 113 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 172
Query: 246 DDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRA 305
D TC L+D+ + Q L + +A S++G ++G D VWD G
Sbjct: 173 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 232
Query: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
H++ ++ + G A A+GS D+ R+++
Sbjct: 233 QAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 267
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 372 bits (955), Expect = e-103
Identities = 178/341 (52%), Positives = 237/341 (69%), Gaps = 5/341 (1%)
Query: 4 LEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYAMHW 63
L L+ EAE L+ ++++ R +D L Q+ ++++G+ M+TRRTL+GH K+ M W
Sbjct: 54 LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 113
Query: 64 GYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 123
D R +VS+SQDGK+I+WDS+TTNK HA+ + +WVM CAYAPSG +ACGGLDN CS+
Sbjct: 114 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 173
Query: 124 YNLK--TREGNVRVSRELPGHTGYLSCCRFLD-DSQIVTSSGDTTCALWDIETAQQTTTF 180
Y L E + + HT YLS C F + D QI+T+SGD TCALWD+E+ Q +F
Sbjct: 174 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 233
Query: 181 TGHSGDVMSLSLSPDM--RTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNG 238
GH DV+ L L+P TFVSG CD + +WD+R G C Q+F H SDIN+V ++P+G
Sbjct: 234 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 293
Query: 239 YAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWD 298
AFA+GSDDATCRL+DLRAD+E+ +YS ++II G +SV FS SGRLL AGY+D+ NVWD
Sbjct: 294 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 353
Query: 299 TLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
LKG R +L GH+NRVS L V+ DG A +GSWD LR+W
Sbjct: 354 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 66.6 bits (161), Expect = 3e-11
Identities = 53/215 (24%), Positives = 92/215 (42%), Gaps = 7/215 (3%)
Query: 133 VRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLS 191
++ R L GH + C + D + IV+SS D +WD T + T VM+ +
Sbjct: 95 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 154
Query: 192 LSPDMRTFVSGACDASSKLW----DIRDGMC--RQSFTGHVSDINAVSFFPNGYAFATGS 245
+P G D ++ D + M ++S H + ++A SF + T S
Sbjct: 155 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 214
Query: 246 DDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRA 305
D TC L+D+ + Q L + +A S++G ++G D VWD G
Sbjct: 215 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 274
Query: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
H++ ++ + G A A+GS D+ R+++
Sbjct: 275 QAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 309
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 122 bits (305), Expect = 6e-28
Identities = 81/294 (27%), Positives = 130/294 (44%), Gaps = 12/294 (4%)
Query: 50 TLRGHLAKIYAMHWG--YDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAP 107
TL GH +YA+ + Y ++ + S D +W T H ++ ++ ++ P
Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKI-ATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNP 187
Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRF-LDDSQIVTSSGDTTC 166
VA G +D +++++ E L GH+ + F +I+T S D T
Sbjct: 188 QSTLVATGSMDTTAKLWDIQNGEEVYT----LRGHSAEIISLSFNTSGDRIITGSFDHTV 243
Query: 167 ALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHV 226
+WD +T ++ GH ++ S S + D ++G+ D + KLWD +G C + TGH
Sbjct: 244 VVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHD 303
Query: 227 SDINAVSFFPNGYAFATGSDDATCRLFDLRADQELL-LYSHDNIICGITSVAFSKSGRLL 285
+I F G AT S D T R+F + + L H+ I+ ++F+ G L
Sbjct: 304 DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEG---EISKISFNPQGNHL 360
Query: 286 LAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
L G D +WD G VL GH + + G V TGS D+ RIW
Sbjct: 361 LTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 117 bits (293), Expect = 1e-26
Identities = 76/295 (25%), Positives = 134/295 (45%), Gaps = 10/295 (3%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYA-P 107
+ L+ H+ + + ++ S D +WD+ + +++ + + V A+ P
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIV-TSSGDTTC 166
G+ +A G D C +++++T + GHT + C F S +V T S DTT
Sbjct: 146 YGDKIATGSFDKTCKLWSVETG----KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTA 201
Query: 167 ALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHV 226
LWDI+ ++ T GHS +++SLS + ++G+ D + +WD G GH
Sbjct: 202 KLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC 261
Query: 227 SDINAVSFFPNGYAFATGSDDATCRLFDLRADQELL-LYSHDNIICGITSVAFSKSGRLL 285
++I++ SF + TGS D TC+L+D + + L HD+ I F +G+L+
Sbjct: 262 AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDD---EILDSCFDYTGKLI 318
Query: 286 LAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
D ++ L GH+ +S + G + TGS D RIW+
Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 121 bits (303), Expect = 1e-27
Identities = 79/291 (27%), Positives = 134/291 (46%), Gaps = 22/291 (7%)
Query: 62 HWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG---------NYV 112
H+ +S++L +A G +W N +H + ++ V + P N
Sbjct: 238 HFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLA 297
Query: 113 ACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIV-TSSGDTTCALWDI 171
+C D +++L + E ++ GHT ++ + + + T+ D + LWD+
Sbjct: 298 SCAA-DGSVKLWSLDSDEPVA----DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352
Query: 172 ETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINA 231
E ++ GHS V ++ D +G DA ++WD+R G C GH+ +I
Sbjct: 353 EAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 412
Query: 232 VSFFPNGYAFATGSDDATCRLFDLRADQELLLY---SHDNIICGITSVAFSKSGRLLLAG 288
++F PNGY ATGS D TC+++DLR Q +Y +H N++ G+ G LL G
Sbjct: 413 INFSPNGYHIATGSGDNTCKVWDLR--QRRCVYTIPAHQNLVTGVKFEPI--HGNFLLTG 468
Query: 289 YDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
D +W LAGH+ +V L ++ DG +AT S+D ++W
Sbjct: 469 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 82.0 bits (201), Expect = 7e-16
Identities = 57/204 (27%), Positives = 90/204 (44%), Gaps = 11/204 (5%)
Query: 146 LSCCRFLDDSQIV-TSSGDTTCALWDIETAQQTTTFTGHSGDV--------MSLSLSPDM 196
+S C F +S+++ T+ C LW + T GH+ +V ++SL P
Sbjct: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293
Query: 197 RTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLR 256
S A D S KLW + GH + V + P+G T D + RL+DL
Sbjct: 294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353
Query: 257 ADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVS 316
A +E+L ++ G+ +AF + G L G D VWD G L GH +
Sbjct: 354 AQEEILHQEGHSM--GVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIY 411
Query: 317 CLGVTDDGMAVATGSWDSFLRIWN 340
+ + +G +ATGS D+ ++W+
Sbjct: 412 GINFSPNGYHIATGSGDNTCKVWD 435
Score = 70.1 bits (170), Expect = 3e-12
Identities = 51/205 (24%), Positives = 83/205 (40%), Gaps = 6/205 (2%)
Query: 51 LRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGN 110
+ GH ++ + W R L + D +WD ++ S V A+ G+
Sbjct: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS 378
Query: 111 YVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDS-QIVTSSGDTTCALW 169
GGLD +++L+T R L GH + F + I T SGD TC +W
Sbjct: 379 LAGTGGLDAFGRVWDLRTG----RCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVW 434
Query: 170 DIETAQQTTTFTGHSGDVMSLSLSPDMRTF-VSGACDASSKLWDIRDGMCRQSFTGHVSD 228
D+ + T H V + P F ++GA D ++K+W ++ GH
Sbjct: 435 DLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK 494
Query: 229 INAVSFFPNGYAFATGSDDATCRLF 253
+ + +G AT S D T +L+
Sbjct: 495 VMGLDISSDGQLIATCSYDRTFKLW 519
Score = 53.1 bits (126), Expect = 3e-07
Identities = 42/145 (28%), Positives = 66/145 (45%), Gaps = 10/145 (6%)
Query: 34 TSNMDSVGRI-QMRTRRT---LRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNK 89
T +D+ GR+ +RT R L GHL +IY +++ + + + S D +WD
Sbjct: 382 TGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC 441
Query: 90 MHAIPLRSSWVMTCAYAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSC 148
++ IP + V + P GN++ G DN I+ T G + + L GH G +
Sbjct: 442 VYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW---THPGWSPL-KTLAGHEGKVMG 497
Query: 149 CRFLDDSQIV-TSSGDTTCALWDIE 172
D Q++ T S D T LW E
Sbjct: 498 LDISSDGQLIATCSYDRTFKLWMAE 522
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 113 bits (282), Expect = 3e-25
Identities = 74/284 (26%), Positives = 132/284 (46%), Gaps = 23/284 (8%)
Query: 74 SQDGKLIIWDSYTTNKMHAIPLRSSWVMTCA------------YAPSGNYVACGGLDNIC 121
S+D K + S + N+ +P ++ + C ++P+G ++A D +
Sbjct: 6 SRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLI 65
Query: 122 SIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDS-QIVTSSGDTTCALWDIETAQQTTTF 180
I+ + + + L GH +S + DS ++V++S D T LWD+ + + T
Sbjct: 66 IIWGAY----DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL 121
Query: 181 TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA 240
GHS V + +P +SG+ D + K+W+++ G C ++ + H ++AV F +G
Sbjct: 122 KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL 181
Query: 241 FATGSDDATCRLFDLRADQEL-LLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDT 299
+GS D CR++D + Q L L DN ++ V FS +G+ +L D +WD
Sbjct: 182 IVSGSYDGLCRIWDAASGQCLKTLVDDDN--PPVSFVKFSPNGKYILTATLDNTLKLWDY 239
Query: 300 LKGDRAGVLAGHDNRVSCLGV---TDDGMAVATGSWDSFLRIWN 340
+G GH N C+ G + +GS D+ + IWN
Sbjct: 240 SRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 283
Score = 93.2 bits (230), Expect = 3e-19
Identities = 68/295 (23%), Positives = 134/295 (45%), Gaps = 9/295 (3%)
Query: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG 109
TL GH + ++ + + L S+S D +IIW +Y + + + A++
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCAL 168
+ + D ++++++ + + L GH+ Y+ CC F S I++ S D T +
Sbjct: 96 SRLVSASDDKTLKLWDVRSG----KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKI 151
Query: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVS- 227
W+++T + T + HS V ++ + VSG+ D ++WD G C ++ +
Sbjct: 152 WEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP 211
Query: 228 DINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYS-HDNIICGITSVAFSKSGRLLL 286
++ V F PNG T + D T +L+D + L Y+ H N I + G+ ++
Sbjct: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIV 271
Query: 287 AGYDDFNCNVWDTLKGDRAGVLAGHDNRV--SCLGVTDDGMAVATGSWDSFLRIW 339
+G +D +W+ + L GH + V + T++ +A A D +++W
Sbjct: 272 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 92.0 bits (227), Expect = 7e-19
Identities = 64/236 (27%), Positives = 108/236 (45%), Gaps = 10/236 (4%)
Query: 41 GRIQMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWV 100
G + +TL GH +I + W DS LVSAS D L +WD + + + S++V
Sbjct: 69 GAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV 128
Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRF-LDDSQIVT 159
C + P N + G D I+ +KT + + L H+ +S F S IV+
Sbjct: 129 FCCNFNPPSNLIISGSFDETVKIWEVKTG----KCLKTLSAHSDPVSAVHFNCSGSLIVS 184
Query: 160 SSGDTTCALWDIETAQQTTTFTGHSGDVMS-LSLSPDMRTFVSGACDASSKLWDIRDGMC 218
S D C +WD + Q T +S + SP+ + ++ D + KLWD G C
Sbjct: 185 GSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRC 244
Query: 219 RQSFTGHVSD---INAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNII 270
+++TGH ++ I A G +GS+D +++L+ + + L H +++
Sbjct: 245 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 300
Score = 55.8 bits (133), Expect = 5e-08
Identities = 45/173 (26%), Positives = 76/173 (43%), Gaps = 17/173 (9%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHA-IPLRSSWVMTCAYAP 107
+TL H + A+H+ L+VS S DG IWD+ + + + + V ++P
Sbjct: 161 KTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSP 220
Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLS--CCRFLDDSQ-----IVTS 160
+G Y+ LDN +++ R L +TG+ + C F + S IV+
Sbjct: 221 NGKYILTATLDNTLKLWDYSR-------GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 273
Query: 161 SGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGAC--DASSKLW 211
S D +W+++T + GH+ V+S + P S A D + KLW
Sbjct: 274 SEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 32.3 bits (72), Expect = 0.62
Identities = 19/77 (24%), Positives = 36/77 (46%), Gaps = 3/77 (3%)
Query: 46 RTRRTLRGHLAKIYAMHWGYD---SRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMT 102
R +T GH + Y + + + +VS S+D + IW+ T + + + V++
Sbjct: 243 RCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 302
Query: 103 CAYAPSGNYVACGGLDN 119
A P+ N +A L+N
Sbjct: 303 AACHPTENLIASAALEN 319
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 111 bits (278), Expect = 8e-25
Identities = 69/246 (28%), Positives = 117/246 (47%), Gaps = 11/246 (4%)
Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQI-V 158
V + ++P+G ++A D + I+ + + + + GH +S + DS + V
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAY----DGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 159 TSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMC 218
++S D T +WD+ + + T GHS V + +P VSG+ D S ++WD++ G C
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
Query: 219 RQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICGITSVA 277
++ H ++AV F +G + S D CR++D + Q L L DN ++ V
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN--PPVSFVK 221
Query: 278 FSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGV---TDDGMAVATGSWDS 334
FS +G+ +LA D +WD KG GH N C+ G + +GS D+
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281
Query: 335 FLRIWN 340
+ IWN
Sbjct: 282 LVYIWN 287
Score = 101 bits (251), Expect = 1e-21
Identities = 68/236 (28%), Positives = 112/236 (47%), Gaps = 10/236 (4%)
Query: 41 GRIQMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWV 100
G + +T+ GH I + W DS LLVSAS D L IWD + + + S++V
Sbjct: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132
Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRF-LDDSQIVT 159
C + P N + G D I+++KT + + LP H+ +S F D S IV+
Sbjct: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTG----KCLKTLPAHSDPVSAVHFNRDGSLIVS 188
Query: 160 SSGDTTCALWDIETAQQTTTFTGHSGDVMS-LSLSPDMRTFVSGACDASSKLWDIRDGMC 218
SS D C +WD + Q T +S + SP+ + ++ D + KLWD G C
Sbjct: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248
Query: 219 RQSFTGHVSD---INAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNII 270
+++TGH ++ I A G +GS+D +++L+ + + L H +++
Sbjct: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304
Score = 92.8 bits (229), Expect = 4e-19
Identities = 70/295 (23%), Positives = 129/295 (43%), Gaps = 9/295 (3%)
Query: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG 109
TL GH + ++ + + L S+S D + IW +Y I + A++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCAL 168
N + D I+++ + + + L GH+ Y+ CC F S IV+ S D + +
Sbjct: 100 NLLVSASDDKTLKIWDVSSG----KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVS- 227
WD++T + T HS V ++ + D VS + D ++WD G C ++ +
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
Query: 228 DINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYS-HDNIICGITSVAFSKSGRLLL 286
++ V F PNG + D T +L+D + L Y+ H N I + G+ ++
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 287 AGYDDFNCNVWDTLKGDRAGVLAGHDNRV--SCLGVTDDGMAVATGSWDSFLRIW 339
+G +D +W+ + L GH + V + T++ +A A D +++W
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 76.6 bits (187), Expect = 3e-14
Identities = 44/163 (26%), Positives = 76/163 (46%), Gaps = 4/163 (2%)
Query: 179 TFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNG 238
T GH+ V S+ SP+ S + D K+W DG ++ +GH I+ V++ +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 239 YAFATGSDDATCRLFDLRADQEL-LLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVW 297
+ SDD T +++D+ + + L L H N + F+ L+++G D + +W
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY---VFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 298 DTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
D G L H + VS + DG + + S+D RIW+
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 57.8 bits (138), Expect = 1e-08
Identities = 46/173 (26%), Positives = 78/173 (45%), Gaps = 17/173 (9%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHA-IPLRSSWVMTCAYAP 107
+TL H + A+H+ D L+VS+S DG IWD+ + + I + V ++P
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLS--CCRFLDDSQ-----IVTS 160
+G Y+ LDN +++ + L +TG+ + C F + S IV+
Sbjct: 225 NGKYILAATLDNTLKLWDYSK-------GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277
Query: 161 SGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGAC--DASSKLW 211
S D +W+++T + GH+ V+S + P S A D + KLW
Sbjct: 278 SEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 111 bits (278), Expect = 8e-25
Identities = 69/246 (28%), Positives = 117/246 (47%), Gaps = 11/246 (4%)
Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQI-V 158
V + ++P+G ++A D + I+ + + + + GH +S + DS + V
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAY----DGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 159 TSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMC 218
++S D T +WD+ + + T GHS V + +P VSG+ D S ++WD++ G C
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
Query: 219 RQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICGITSVA 277
++ H ++AV F +G + S D CR++D + Q L L DN ++ V
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN--PPVSFVK 221
Query: 278 FSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGV---TDDGMAVATGSWDS 334
FS +G+ +LA D +WD KG GH N C+ G + +GS D+
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281
Query: 335 FLRIWN 340
+ IWN
Sbjct: 282 LVYIWN 287
Score = 101 bits (251), Expect = 1e-21
Identities = 68/236 (28%), Positives = 112/236 (47%), Gaps = 10/236 (4%)
Query: 41 GRIQMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWV 100
G + +T+ GH I + W DS LLVSAS D L IWD + + + S++V
Sbjct: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132
Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRF-LDDSQIVT 159
C + P N + G D I+++KT + + LP H+ +S F D S IV+
Sbjct: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTG----KCLKTLPAHSDPVSAVHFNRDGSLIVS 188
Query: 160 SSGDTTCALWDIETAQQTTTFTGHSGDVMS-LSLSPDMRTFVSGACDASSKLWDIRDGMC 218
SS D C +WD + Q T +S + SP+ + ++ D + KLWD G C
Sbjct: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248
Query: 219 RQSFTGHVSD---INAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNII 270
+++TGH ++ I A G +GS+D +++L+ + + L H +++
Sbjct: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304
Score = 92.8 bits (229), Expect = 4e-19
Identities = 70/295 (23%), Positives = 129/295 (43%), Gaps = 9/295 (3%)
Query: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG 109
TL GH + ++ + + L S+S D + IW +Y I + A++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCAL 168
N + D I+++ + + + L GH+ Y+ CC F S IV+ S D + +
Sbjct: 100 NLLVSASDDKTLKIWDVSSG----KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVS- 227
WD++T + T HS V ++ + D VS + D ++WD G C ++ +
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
Query: 228 DINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYS-HDNIICGITSVAFSKSGRLLL 286
++ V F PNG + D T +L+D + L Y+ H N I + G+ ++
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 287 AGYDDFNCNVWDTLKGDRAGVLAGHDNRV--SCLGVTDDGMAVATGSWDSFLRIW 339
+G +D +W+ + L GH + V + T++ +A A D +++W
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 76.6 bits (187), Expect = 3e-14
Identities = 44/163 (26%), Positives = 76/163 (46%), Gaps = 4/163 (2%)
Query: 179 TFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNG 238
T GH+ V S+ SP+ S + D K+W DG ++ +GH I+ V++ +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 239 YAFATGSDDATCRLFDLRADQEL-LLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVW 297
+ SDD T +++D+ + + L L H N + F+ L+++G D + +W
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY---VFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 298 DTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
D G L H + VS + DG + + S+D RIW+
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 57.8 bits (138), Expect = 1e-08
Identities = 46/173 (26%), Positives = 78/173 (45%), Gaps = 17/173 (9%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHA-IPLRSSWVMTCAYAP 107
+TL H + A+H+ D L+VS+S DG IWD+ + + I + V ++P
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLS--CCRFLDDSQ-----IVTS 160
+G Y+ LDN +++ + L +TG+ + C F + S IV+
Sbjct: 225 NGKYILAATLDNTLKLWDYSK-------GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277
Query: 161 SGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGAC--DASSKLW 211
S D +W+++T + GH+ V+S + P S A D + KLW
Sbjct: 278 SEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 111 bits (277), Expect = 1e-24
Identities = 74/246 (30%), Positives = 112/246 (45%), Gaps = 13/246 (5%)
Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVT 159
V + A++P G + G D +Y +TR G ++ L GHTG + CRF D +
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGC--VYGWETRSG--QLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 160 SSG-DTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMC 218
S+ D T LWD+ A+ GH V ++S SPD R SG D LWD++ G
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 219 RQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLR----ADQELLLYSHDNIICGIT 274
+ GH I + F P ATGS D+T ++DLR A L H I+
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHS---ANIS 196
Query: 275 SVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334
+ +S SG LL +G D ++W L GH V + + D + +A+ +
Sbjct: 197 CLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSR 255
Query: 335 FLRIWN 340
+++W+
Sbjct: 256 MVKVWD 261
Score = 89.7 bits (221), Expect = 3e-18
Identities = 69/289 (23%), Positives = 126/289 (43%), Gaps = 13/289 (4%)
Query: 54 HLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVA 113
H ++ + + D ++L++ S+DG + W++ + + + + V C ++P G+ A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 114 CGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSG-DTTCALWDIE 172
D ++++ + R L GH + F DS+ + S G D LWD++
Sbjct: 80 SASCDCTVRLWDV----ARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ 135
Query: 173 TAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIR---DGMCRQSFTGHVSDI 229
+ Q GH + S SP + +G+ D++ +WD+R + Q+ GH ++I
Sbjct: 136 SGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI 195
Query: 230 NAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGR-LLLAG 288
+ + + +G A+GS D T ++ + LL + + S+AFS L AG
Sbjct: 196 SCLCYSASG-LLASGSWDKTIHIW--KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAG 252
Query: 289 YDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLR 337
Y VWD G L G + T DG + +G+ D R
Sbjct: 253 YSRM-VKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 87.4 bits (215), Expect = 2e-17
Identities = 52/162 (32%), Positives = 78/162 (48%), Gaps = 4/162 (2%)
Query: 180 FTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGY 239
F H G+V S + SPD + ++G+ D W+ R G GH + F P+G+
Sbjct: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76
Query: 240 AFATGSDDATCRLFDL-RADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWD 298
FA+ S D T RL+D+ RA +L H + +V+FS R L +G D +WD
Sbjct: 77 LFASASCDCTVRLWDVARAKCLRVLKGHQR---SVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 299 TLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
G +L GH + + + +ATGSWDS + IW+
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
Score = 86.7 bits (213), Expect = 3e-17
Identities = 51/203 (25%), Positives = 91/203 (44%), Gaps = 1/203 (0%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPS 108
R L+GH + + + DSR L S D ++++WD + + + + + ++P+
Sbjct: 99 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158
Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCAL 168
N +A G D+ I++L+ V + L GH+ +SC + + + S D T +
Sbjct: 159 VNCLATGSWDSTVHIWDLRMVTPAVS-HQALEGHSANISCLCYSASGLLASGSWDKTIHI 217
Query: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSD 228
W T+ GH V S++ SPD S K+WD G C ++ G +
Sbjct: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277
Query: 229 INAVSFFPNGYAFATGSDDATCR 251
+ +F P+G +G+ D T R
Sbjct: 278 AHTCAFTPDGKILVSGAADQTRR 300
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 111 bits (277), Expect = 1e-24
Identities = 62/203 (30%), Positives = 104/203 (51%), Gaps = 3/203 (1%)
Query: 139 LPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMR 197
L GH G + RFL DS +++ S D + WD+ + T + GH+ V L +SP
Sbjct: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSL 397
Query: 198 TFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRA 257
F SG+ D +++LW + + GH++D++ V F PN ATGS D T RL+ +
Sbjct: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457
Query: 258 DQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSC 317
+ L++ + S+AFS +G+ L + +D +WD G L GH + ++
Sbjct: 458 GNSVRLFTGHR--GPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITS 515
Query: 318 LGVTDDGMAVATGSWDSFLRIWN 340
L + D +A+ S D+ +R+W+
Sbjct: 516 LTFSPDSGLIASASMDNSVRVWD 538
Score = 98.6 bits (244), Expect = 7e-21
Identities = 73/260 (28%), Positives = 116/260 (44%), Gaps = 24/260 (9%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWD--SYTTNKM---HAIPLRSSWVMTC 103
+ LRGH +Y+ + DS L+S S+D + WD S+T + HA P+ W +
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV---WDLDI 392
Query: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ-IVTSSG 162
+ P Y A G D +++ R +R+ GH + C +F +S + T S
Sbjct: 393 S--PYSLYFASGSHDRTARLWSFD-RTYPLRI---YAGHLADVDCVKFHPNSNYLATGST 446
Query: 163 DTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSF 222
D T LW + FTGH G V+SL+ SP+ + S D KLWD+ G +
Sbjct: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
Query: 223 TGHVSDINAVSFFPNGYAFATGSDDATCRLFDLR---------ADQELLLYSHDNIICGI 273
GH +I +++F P+ A+ S D + R++D+R L+ + + +
Sbjct: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNV 566
Query: 274 TSVAFSKSGRLLLAGYDDFN 293
SV F LL+ G N
Sbjct: 567 LSVQFMACNLLLVTGITQEN 586
Score = 38.5 bits (88), Expect = 0.009
Identities = 35/181 (19%), Positives = 63/181 (34%), Gaps = 34/181 (18%)
Query: 192 LSPDMRTFVSGACDASSKLWDIRD--------------------------------GMCR 219
+SPD + +G ++ KLW +R G
Sbjct: 276 ISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEM 335
Query: 220 QSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFS 279
+ GH + + F + + S+D + R +DL + +LY + + S
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLY--QGHAYPVWDLDIS 393
Query: 280 KSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
+G D +W + + AGH V C+ + +ATGS D +R+W
Sbjct: 394 PYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLW 453
Query: 340 N 340
+
Sbjct: 454 S 454
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 107 bits (267), Expect = 2e-23
Identities = 70/204 (34%), Positives = 100/204 (49%), Gaps = 5/204 (2%)
Query: 139 LPGHTGYLSCCRFLDD-SQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMR 197
L GH+G + F D + +++SS D T LW ++T + GH+ V SP
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
Query: 198 TFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFD-LR 256
FVSG D ++LW + F GH++D+N F PN ATGS D T RL+D L
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
Query: 257 ADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVS 316
+ + H I +T FS +GR L G D +WD G G L GH + V
Sbjct: 659 GNCVRIFTGHKGPIHSLT---FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
Query: 317 CLGVTDDGMAVATGSWDSFLRIWN 340
L + DG +A+GS D+ +R+W+
Sbjct: 716 SLRFSRDGEILASGSMDNTVRLWD 739
Score = 106 bits (265), Expect = 3e-23
Identities = 66/215 (30%), Positives = 102/215 (47%), Gaps = 6/215 (2%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPS 108
+ L GH +Y + D L+S+S+DG + +W T + + V ++P
Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596
Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIV-TSSGDTTCA 167
G Y GG D + ++ + + R GH ++C RF +S V T S D T
Sbjct: 597 GYYFVSGGHDRVARLW----ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652
Query: 168 LWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVS 227
LWD+ FTGH G + SL+ SP+ R +GA D LWDI G+ GH
Sbjct: 653 LWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD 712
Query: 228 DINAVSFFPNGYAFATGSDDATCRLFD-LRADQEL 261
+ ++ F +G A+GS D T RL+D ++A ++L
Sbjct: 713 TVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDL 747
Score = 94.4 bits (233), Expect = 1e-19
Identities = 67/247 (27%), Positives = 110/247 (44%), Gaps = 9/247 (3%)
Query: 57 KIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGG 116
K+ ++ D L+ S D I D T +++ + S V +++P NY+
Sbjct: 503 KLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSS 562
Query: 117 LDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSG-DTTCALWDIETAQ 175
D +++L+T V GH + +F S G D LW + Q
Sbjct: 563 EDGTVRLWSLQTFTCLVGYK----GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQ 618
Query: 176 QTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFF 235
F GH DV P+ +G+ D + +LWD+ +G C + FTGH I++++F
Sbjct: 619 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 678
Query: 236 PNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICGITSVAFSKSGRLLLAGYDDFNC 294
PNG ATG+ D L+D+ + L H + +C S+ FS+ G +L +G D
Sbjct: 679 PNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC---SLRFSRDGEILASGSMDNTV 735
Query: 295 NVWDTLK 301
+WD +K
Sbjct: 736 RLWDAIK 742
Score = 86.7 bits (213), Expect = 3e-17
Identities = 51/188 (27%), Positives = 82/188 (43%), Gaps = 2/188 (1%)
Query: 153 DDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWD 212
D S I S D + D +TA + GHSG V S SPD +S + D + +LW
Sbjct: 512 DLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWS 571
Query: 213 IRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICG 272
++ C + GH + F P GY F +G D RL+ Q L +++ +
Sbjct: 572 LQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFA--GHLAD 629
Query: 273 ITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332
+ F + + G D +WD L G+ + GH + L + +G +ATG+
Sbjct: 630 VNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGAT 689
Query: 333 DSFLRIWN 340
D + +W+
Sbjct: 690 DGRVLLWD 697
Score = 56.6 bits (135), Expect = 3e-08
Identities = 54/233 (23%), Positives = 91/233 (39%), Gaps = 23/233 (9%)
Query: 118 DNICSIYNLKTREGNVRVSRE-LPGHTGY--------LSCCRFLDDSQIVTSS-GDTTCA 167
D + I N+K VR+ + LP Y L+ DDS ++ D+T
Sbjct: 436 DKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVR 495
Query: 168 LWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVS 227
+W + + + S+ + D+ + D ++ D + + GH
Sbjct: 496 VWSVTPKK-----------LRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSG 544
Query: 228 DINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLA 287
+ SF P+ + S+D T RL+ L+ L+ Y N + FS G ++
Sbjct: 545 PVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNY--PVWDTQFSPYGYYFVS 602
Query: 288 GYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
G D +W T + AGH V+C + VATGS D +R+W+
Sbjct: 603 GGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 107 bits (267), Expect = 2e-23
Identities = 93/340 (27%), Positives = 141/340 (41%), Gaps = 57/340 (16%)
Query: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKM-HAIPLRSSWVMTCAYAP- 107
T +GH + ++ W D R L S ++G++++WD T ++ + S W+ ++ P
Sbjct: 151 TCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPL 210
Query: 108 ----SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGD 163
YVA D I++ T G R R L GHT ++C R+ D + ++S D
Sbjct: 211 HANPECRYVASSSKDGSVRIWD--TTAG--RCERILTGHTQSVTCLRWGGDGLLYSASQD 266
Query: 164 TTCALWDIETAQQTTTFTGHSGDVMSLSLSPD--MRT----------------------- 198
T +W T GH V +++LS D +RT
Sbjct: 267 RTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELK 326
Query: 199 -----------------FVSGACDASSKLWD-IRDGMCRQSFTGHVSDINAVSFFPNGYA 240
VSG+ D + LW D TGH + IN V F P+
Sbjct: 327 ERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRI 386
Query: 241 FATGSDDATCRLFDLRADQELL-LYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDT 299
A+ S D + +L+D R + L L H + + +A+S RLL++G D VWD
Sbjct: 387 VASASFDKSIKLWDGRTGKYLASLRGH---VAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
Query: 300 LKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
A L GH + V + + DG VA+G D LRIW
Sbjct: 444 KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 89.0 bits (219), Expect = 6e-18
Identities = 67/254 (26%), Positives = 116/254 (45%), Gaps = 9/254 (3%)
Query: 46 RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAY 105
R R L GH + + WG D LL SASQD + +W ++ + WV T A
Sbjct: 237 RCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMAL 295
Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTT 165
+ + + G + + N + +G+++ +E + R ++V+ S D T
Sbjct: 296 S-TDYALRTGAFEPAEASVNPQDLQGSLQELKERA--LSRYNLVRGQGPERLVSGSDDFT 352
Query: 166 CALWD-IETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTG 224
LW E + T TGH + + SPD R S + D S KLWD R G S G
Sbjct: 353 LFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRG 412
Query: 225 HVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELL-LYSHDNIICGITSVAFSKSGR 283
HV+ + +++ + +GS D+T +++D++A + + L H + + +V +S G+
Sbjct: 413 HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHAD---EVYAVDWSPDGQ 469
Query: 284 LLLAGYDDFNCNVW 297
+ +G D +W
Sbjct: 470 RVASGGKDKCLRIW 483
Score = 80.9 bits (198), Expect = 2e-15
Identities = 77/338 (22%), Positives = 146/338 (43%), Gaps = 37/338 (10%)
Query: 23 KACNDATLVQITSNMDSVGRIQMRTRRT--LRGHLAKIYAMHWGYDSRLLVSASQDGKLI 80
+A ++ I ++ R++ TR T L GH + ++ + + L S S D +
Sbjct: 80 QAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVR 139
Query: 81 IWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELP 140
WD T WV++ +++P G +A G + +++ T + +V R L
Sbjct: 140 FWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGK---QVGRTLA 196
Query: 141 GHTGYLSC-----------CRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMS 189
GH+ +++ CR+ + +SS D + +WD + TGH+ V
Sbjct: 197 GHSKWITGLSWEPLHANPECRY-----VASSSKDGSVRIWDTTAGRCERILTGHTQSVTC 251
Query: 190 LSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGS---D 246
L D + S + D + K+W DG+ ++ GH +N ++ YA TG+
Sbjct: 252 LRWGGDGLLY-SASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMA-LSTDYALRTGAFEPA 309
Query: 247 DATCRLFDLRAD-QEL--LLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGD 303
+A+ DL+ QEL S N++ G + L++G DDF +W +
Sbjct: 310 EASVNPQDLQGSLQELKERALSRYNLVRG-------QGPERLVSGSDDFTLFLWSPAEDK 362
Query: 304 RAGV-LAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
+ + GH ++ + + D VA+ S+D +++W+
Sbjct: 363 KPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 104 bits (260), Expect = 1e-22
Identities = 73/292 (25%), Positives = 122/292 (41%), Gaps = 7/292 (2%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPS 108
R +GH + + + +++ L S S D L++W ++ + V ++PS
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCA 167
G+ +A G D I+ + +G V R HT + F D Q VT+S D T
Sbjct: 73 GHLLASGSRDKTVRIW-VPNVKGESTVFR---AHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 168 LWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVS 227
+W + + + H V SPD R VS + D + KLWD C S+ H
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 228 DINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLA 287
+ V F P+G A D T +++D+R + LL + + ++F SG L+
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR--LLQHYQLHSAAVNGLSFHPSGNYLIT 246
Query: 288 GYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
D + D ++G L GH + + + G A+G D + +W
Sbjct: 247 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 85.1 bits (209), Expect = 8e-17
Identities = 49/207 (23%), Positives = 92/207 (44%), Gaps = 3/207 (1%)
Query: 135 VSRELPGHTGYLSCCRF-LDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLS 193
+ R GH ++C F ++ Q+ + S D+ +W ++ + FTGH V ++ S
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 194 PDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLF 253
P SG+ D + ++W F H + + +V F +G +F T SDD T +++
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 254 DLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDN 313
++ L+S I + FS GRL+++ DD +WD + H
Sbjct: 131 --ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 314 RVSCLGVTDDGMAVATGSWDSFLRIWN 340
V+ + G +A D+ +++W+
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Score = 48.1 bits (113), Expect = 1e-05
Identities = 34/127 (26%), Positives = 56/127 (44%), Gaps = 6/127 (4%)
Query: 215 DGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYS-HDNIICGI 273
D + F GH + V F N A+GS D+ ++ ++ ++ H + +
Sbjct: 8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD---AV 64
Query: 274 TSVAFSKSGRLLLAGYDDFNCNVW-DTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332
T V FS SG LL +G D +W +KG+ + V H V + DG + T S
Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIWVPNVKGE-STVFRAHTATVRSVHFCSDGQSFVTASD 123
Query: 333 DSFLRIW 339
D +++W
Sbjct: 124 DKTVKVW 130
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 104 bits (260), Expect = 1e-22
Identities = 73/292 (25%), Positives = 122/292 (41%), Gaps = 7/292 (2%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPS 108
R +GH + + + +++ L S S D L++W ++ + V ++PS
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCA 167
G+ +A G D I+ + +G V R HT + F D Q VT+S D T
Sbjct: 73 GHLLASGSRDKTVRIW-VPNVKGESTVFR---AHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 168 LWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVS 227
+W + + + H V SPD R VS + D + KLWD C S+ H
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 228 DINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLA 287
+ V F P+G A D T +++D+R + LL + + ++F SG L+
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR--LLQHYQLHSAAVNGLSFHPSGNYLIT 246
Query: 288 GYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
D + D ++G L GH + + + G A+G D + +W
Sbjct: 247 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 85.1 bits (209), Expect = 8e-17
Identities = 49/207 (23%), Positives = 92/207 (44%), Gaps = 3/207 (1%)
Query: 135 VSRELPGHTGYLSCCRF-LDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLS 193
+ R GH ++C F ++ Q+ + S D+ +W ++ + FTGH V ++ S
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 194 PDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLF 253
P SG+ D + ++W F H + + +V F +G +F T SDD T +++
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 254 DLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDN 313
++ L+S I + FS GRL+++ DD +WD + H
Sbjct: 131 --ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 314 RVSCLGVTDDGMAVATGSWDSFLRIWN 340
V+ + G +A D+ +++W+
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Score = 48.1 bits (113), Expect = 1e-05
Identities = 34/127 (26%), Positives = 56/127 (44%), Gaps = 6/127 (4%)
Query: 215 DGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYS-HDNIICGI 273
D + F GH + V F N A+GS D+ ++ ++ ++ H + +
Sbjct: 8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD---AV 64
Query: 274 TSVAFSKSGRLLLAGYDDFNCNVW-DTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332
T V FS SG LL +G D +W +KG+ + V H V + DG + T S
Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIWVPNVKGE-STVFRAHTATVRSVHFCSDGQSFVTASD 123
Query: 333 DSFLRIW 339
D +++W
Sbjct: 124 DKTVKVW 130
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 102 bits (253), Expect = 6e-22
Identities = 74/293 (25%), Positives = 128/293 (43%), Gaps = 9/293 (3%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPS 108
R +GH A I ++ + + L +AS D L++W+ + + V + ++P
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCA 167
GN +A D ++ + + G E HT + F D Q + T+S D +
Sbjct: 72 GNLLASASRDRTVRLW-IPDKRGKFS---EFKAHTAPVRSVDFSADGQFLATASEDKSIK 127
Query: 168 LWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVS 227
+W + + + H+ V SPD R VS + D + K+WD + C +F+ V
Sbjct: 128 VWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVG 187
Query: 228 DINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYS-HDNIICGITSVAFSKSGRLLL 286
N V F P+G A+ D T +++D+R ++ L Y H G+ ++F SG L+
Sbjct: 188 FANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG---GVNCISFHPSGNYLI 244
Query: 287 AGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
D + D L+G L GH V + + G A+G D+ + +W
Sbjct: 245 TASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 97.8 bits (242), Expect = 1e-20
Identities = 65/253 (25%), Positives = 111/253 (43%), Gaps = 17/253 (6%)
Query: 53 GHLAKIYAMHWGYDSRLLVSASQDGKLIIW-----DSYTTNKMHAIPLRSSWVMTCAYAP 107
GH + ++ + LL SAS+D + +W ++ K H P+RS ++
Sbjct: 58 GHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRS-----VDFSA 112
Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTS-SGDTTC 166
G ++A D ++++ + R L HT ++ C +F D +++ S S D T
Sbjct: 113 DGQFLATASEDKSIKVWSMYRQ----RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTI 168
Query: 167 ALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHV 226
+WD Q F+ G + +P S D + K+WD+R Q + H
Sbjct: 169 KIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHS 228
Query: 227 SDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLL 286
+N +SF P+G T S D T ++ DL + L+Y+ + +V+FSK G L
Sbjct: 229 GGVNCISFHPSGNYLITASSDGTLKILDLLEGR--LIYTLQGHTGPVFTVSFSKGGELFA 286
Query: 287 AGYDDFNCNVWDT 299
+G D +W T
Sbjct: 287 SGGADTQVLLWRT 299
Score = 80.9 bits (198), Expect = 2e-15
Identities = 46/209 (22%), Positives = 88/209 (42%), Gaps = 5/209 (2%)
Query: 52 RGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNY 111
+ H A + ++ + D + L +AS+D + +W Y ++++ + WV ++P G
Sbjct: 99 KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRL 158
Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSG-DTTCALWD 170
+ D I++ N + G+ + F + S+G D T +WD
Sbjct: 159 IVSCSEDKTIKIWDTT----NKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
Query: 171 IETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDIN 230
+ + + HSG V +S P ++ + D + K+ D+ +G + GH +
Sbjct: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
Query: 231 AVSFFPNGYAFATGSDDATCRLFDLRADQ 259
VSF G FA+G D L+ D+
Sbjct: 275 TVSFSKGGELFASGGADTQVLLWRTNFDE 303
Score = 70.5 bits (171), Expect = 2e-12
Identities = 46/187 (24%), Positives = 84/187 (44%), Gaps = 6/187 (3%)
Query: 156 QIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRD 215
Q+ T+S DT LW+ + + + GH V S+ SP S + D + +LW I D
Sbjct: 32 QLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW-IPD 90
Query: 216 GMCRQS-FTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELL-LYSHDNIICGI 273
+ S F H + + +V F +G AT S+D + +++ + + L LY H + +
Sbjct: 91 KRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTH---WV 147
Query: 274 TSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333
FS GRL+++ +D +WDT + + + G +A+ D
Sbjct: 148 RCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSD 207
Query: 334 SFLRIWN 340
+++W+
Sbjct: 208 QTVKVWD 214
Score = 67.8 bits (164), Expect = 1e-11
Identities = 43/161 (26%), Positives = 69/161 (42%), Gaps = 2/161 (1%)
Query: 180 FTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGY 239
F GH + SL LSP+ + + + D LW+ + + GH + +V F P+G
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 240 AFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDT 299
A+ S D T RL+ D+ + SV FS G+ L +D + VW
Sbjct: 74 LLASASRDRTVRLW--IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
Query: 300 LKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
+ L H + V C + DG + + S D ++IW+
Sbjct: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/127 (27%), Positives = 56/127 (44%), Gaps = 4/127 (3%)
Query: 215 DGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLY-SHDNIICGI 273
D + + F GH + I ++ PNG AT S D L++ + Y H ++ +
Sbjct: 7 DPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDV---V 63
Query: 274 TSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333
TSV FS G LL + D +W K + H V + + DG +AT S D
Sbjct: 64 TSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASED 123
Query: 334 SFLRIWN 340
+++W+
Sbjct: 124 KSIKVWS 130
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 100 bits (249), Expect = 2e-21
Identities = 55/190 (28%), Positives = 99/190 (52%), Gaps = 5/190 (2%)
Query: 66 DSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125
DS+ L + + GK+ I+ + K +++ R ++++ AY+P G Y+A G +D I +I++
Sbjct: 117 DSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFD 176
Query: 126 LKTREGNVRVSRELPGHTGYLSCCRFLDDSQI-VTSSGDTTCALWDIETAQQTTTFTGHS 184
+ T ++ L GH + F DSQ+ VT+S D ++D++ A T +GH+
Sbjct: 177 IATG----KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA 232
Query: 185 GDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATG 244
V++++ PD FVS + D S K+WD+ C +F H + V + NG +
Sbjct: 233 SWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSV 292
Query: 245 SDDATCRLFD 254
DD ++D
Sbjct: 293 GDDQEIHIYD 302
Score = 77.4 bits (189), Expect = 2e-14
Identities = 55/230 (23%), Positives = 100/230 (43%), Gaps = 5/230 (2%)
Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSG-DTTCALWD 170
V G LD++ ++ K R+ + + L GH + I SS D LWD
Sbjct: 35 VVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
Query: 171 IETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDIN 230
+E +Q + D +L+ SPD + +G ++ + G S I
Sbjct: 93 LENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFIL 152
Query: 231 AVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYD 290
++++ P+G A+G+ D +FD+ + LL++ + I S+ FS +LL+ D
Sbjct: 153 SIAYSPDGKYLASGAIDGIINIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
Query: 291 DFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
D ++D + AG L+GH + V + D + S D +++W+
Sbjct: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
Score = 75.5 bits (184), Expect = 6e-14
Identities = 57/273 (20%), Positives = 127/273 (46%), Gaps = 13/273 (4%)
Query: 33 ITSNMDSVGRI------QMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYT 86
+T ++D + ++ ++ + +L GH + ++ + + S+S D + +WD
Sbjct: 36 VTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLEN 95
Query: 87 TNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYL 146
++ +I T A++P Y+A G +I+ +++ G S + G L
Sbjct: 96 GKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES--GKKEYSLDTRGKF-IL 152
Query: 147 SCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDA 206
S D + + + D ++DI T + T GH+ + SL+ SPD + V+ + D
Sbjct: 153 SIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDG 212
Query: 207 SSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYS 265
K++D++ + +GH S + V+F P+ F + S D + +++D+ + +
Sbjct: 213 YIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFD 272
Query: 266 HDNIICGITSVAFSKSGRLLLAGYDDFNCNVWD 298
H + + G V ++ +G +++ DD +++D
Sbjct: 273 HQDQVWG---VKYNGNGSKIVSVGDDQEIHIYD 302
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 98.6 bits (244), Expect = 7e-21
Identities = 64/213 (30%), Positives = 103/213 (48%), Gaps = 12/213 (5%)
Query: 129 REGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVM 188
R G ++ + L GH ++ C ++IV+ S D T +W T + T GH+G V
Sbjct: 248 RRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW 307
Query: 189 SLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDA 248
S + ++ +SG+ D + K+W+ G C + GH S + + +GS DA
Sbjct: 308 SSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDA 363
Query: 249 TCRLFDLRADQEL-LLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGV 307
T R++D+ Q L +L H + + V + GR +++G DF VWD
Sbjct: 364 TLRVWDIETGQCLHVLMGH---VAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 418
Query: 308 LAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
L GH NRV L DG+ V +GS D+ +R+W+
Sbjct: 419 LQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 449
Score = 88.6 bits (218), Expect = 7e-18
Identities = 69/242 (28%), Positives = 118/242 (48%), Gaps = 18/242 (7%)
Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVT 159
V+TC GN + G DN +++ T + R L GHTG + + + D+ I++
Sbjct: 265 VITCLQF-CGNRIVSGSDDNTLKVWSAVTG----KCLRTLVGHTGGVWSSQ-MRDNIIIS 318
Query: 160 SSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCR 219
S D T +W+ ET + T GH+ V + L + VSG+ DA+ ++WDI G C
Sbjct: 319 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCL 376
Query: 220 QSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICGITSVAF 278
GHV+ + V + +G +G+ D +++D + L L H N + S+ F
Sbjct: 377 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN---RVYSLQF 431
Query: 279 SKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRI 338
G +++G D + VWD G+ L GH + S + + D+ + +G+ DS ++I
Sbjct: 432 D--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKI 487
Query: 339 WN 340
W+
Sbjct: 488 WD 489
Score = 85.1 bits (209), Expect = 8e-17
Identities = 66/256 (25%), Positives = 119/256 (46%), Gaps = 16/256 (6%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPS 108
RTL GH +++ +++S S D L +W++ T +H + +S V C +
Sbjct: 297 RTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR-CMHLHE 353
Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCAL 168
V+ G D +++++T + L GH + C ++ D ++V+ + D +
Sbjct: 354 KRVVS-GSRDATLRVWDIETGQ----CLHVLMGHVAAVRCVQY-DGRRVVSGAYDFMVKV 407
Query: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSD 228
WD ET T GH+ V SL D VSG+ D S ++WD+ G C + TGH S
Sbjct: 408 WDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL 465
Query: 229 INAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICGITSVAFSKSGRLLLA 287
+ + N +G+ D+T +++D++ Q L L + +T + F+K+ ++
Sbjct: 466 TSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVIT 521
Query: 288 GYDDFNCNVWDTLKGD 303
DD +WD G+
Sbjct: 522 SSDDGTVKLWDLKTGE 537
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 98.6 bits (244), Expect = 7e-21
Identities = 64/213 (30%), Positives = 103/213 (48%), Gaps = 12/213 (5%)
Query: 129 REGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVM 188
R G ++ + L GH ++ C ++IV+ S D T +W T + T GH+G V
Sbjct: 366 RRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW 425
Query: 189 SLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDA 248
S + ++ +SG+ D + K+W+ G C + GH S + + +GS DA
Sbjct: 426 SSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDA 481
Query: 249 TCRLFDLRADQEL-LLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGV 307
T R++D+ Q L +L H + + V + GR +++G DF VWD
Sbjct: 482 TLRVWDIETGQCLHVLMGH---VAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 536
Query: 308 LAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
L GH NRV L DG+ V +GS D+ +R+W+
Sbjct: 537 LQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 567
Score = 88.6 bits (218), Expect = 7e-18
Identities = 69/242 (28%), Positives = 118/242 (48%), Gaps = 18/242 (7%)
Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVT 159
V+TC GN + G DN +++ T + R L GHTG + + + D+ I++
Sbjct: 383 VITCLQF-CGNRIVSGSDDNTLKVWSAVTG----KCLRTLVGHTGGVWSSQ-MRDNIIIS 436
Query: 160 SSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCR 219
S D T +W+ ET + T GH+ V + L + VSG+ DA+ ++WDI G C
Sbjct: 437 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCL 494
Query: 220 QSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICGITSVAF 278
GHV+ + V + +G +G+ D +++D + L L H N + S+ F
Sbjct: 495 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN---RVYSLQF 549
Query: 279 SKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRI 338
G +++G D + VWD G+ L GH + S + + D+ + +G+ DS ++I
Sbjct: 550 D--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKI 605
Query: 339 WN 340
W+
Sbjct: 606 WD 607
Score = 85.1 bits (209), Expect = 8e-17
Identities = 66/256 (25%), Positives = 119/256 (46%), Gaps = 16/256 (6%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPS 108
RTL GH +++ +++S S D L +W++ T +H + +S V C +
Sbjct: 415 RTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR-CMHLHE 471
Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCAL 168
V+ G D +++++T + L GH + C ++ D ++V+ + D +
Sbjct: 472 KRVVS-GSRDATLRVWDIETGQ----CLHVLMGHVAAVRCVQY-DGRRVVSGAYDFMVKV 525
Query: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSD 228
WD ET T GH+ V SL D VSG+ D S ++WD+ G C + TGH S
Sbjct: 526 WDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL 583
Query: 229 INAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICGITSVAFSKSGRLLLA 287
+ + N +G+ D+T +++D++ Q L L + +T + F+K+ ++
Sbjct: 584 TSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVIT 639
Query: 288 GYDDFNCNVWDTLKGD 303
DD +WD G+
Sbjct: 640 SSDDGTVKLWDLKTGE 655
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 98.6 bits (244), Expect = 7e-21
Identities = 64/213 (30%), Positives = 103/213 (48%), Gaps = 12/213 (5%)
Query: 129 REGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVM 188
R G ++ + L GH ++ C ++IV+ S D T +W T + T GH+G V
Sbjct: 286 RRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW 345
Query: 189 SLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDA 248
S + ++ +SG+ D + K+W+ G C + GH S + + +GS DA
Sbjct: 346 SSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDA 401
Query: 249 TCRLFDLRADQEL-LLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGV 307
T R++D+ Q L +L H + + V + GR +++G DF VWD
Sbjct: 402 TLRVWDIETGQCLHVLMGH---VAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 456
Query: 308 LAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
L GH NRV L DG+ V +GS D+ +R+W+
Sbjct: 457 LQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 487
Score = 88.6 bits (218), Expect = 7e-18
Identities = 69/242 (28%), Positives = 118/242 (48%), Gaps = 18/242 (7%)
Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVT 159
V+TC GN + G DN +++ T + R L GHTG + + + D+ I++
Sbjct: 303 VITCLQF-CGNRIVSGSDDNTLKVWSAVTG----KCLRTLVGHTGGVWSSQ-MRDNIIIS 356
Query: 160 SSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCR 219
S D T +W+ ET + T GH+ V + L + VSG+ DA+ ++WDI G C
Sbjct: 357 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCL 414
Query: 220 QSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICGITSVAF 278
GHV+ + V + +G +G+ D +++D + L L H N + S+ F
Sbjct: 415 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN---RVYSLQF 469
Query: 279 SKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRI 338
G +++G D + VWD G+ L GH + S + + D+ + +G+ DS ++I
Sbjct: 470 D--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKI 525
Query: 339 WN 340
W+
Sbjct: 526 WD 527
Score = 85.1 bits (209), Expect = 8e-17
Identities = 66/256 (25%), Positives = 119/256 (46%), Gaps = 16/256 (6%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPS 108
RTL GH +++ +++S S D L +W++ T +H + +S V C +
Sbjct: 335 RTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR-CMHLHE 391
Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCAL 168
V+ G D +++++T + L GH + C ++ D ++V+ + D +
Sbjct: 392 KRVVS-GSRDATLRVWDIETGQ----CLHVLMGHVAAVRCVQY-DGRRVVSGAYDFMVKV 445
Query: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSD 228
WD ET T GH+ V SL D VSG+ D S ++WD+ G C + TGH S
Sbjct: 446 WDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL 503
Query: 229 INAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICGITSVAFSKSGRLLLA 287
+ + N +G+ D+T +++D++ Q L L + +T + F+K+ ++
Sbjct: 504 TSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVIT 559
Query: 288 GYDDFNCNVWDTLKGD 303
DD +WD G+
Sbjct: 560 SSDDGTVKLWDLKTGE 575
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 98.6 bits (244), Expect = 7e-21
Identities = 70/250 (28%), Positives = 111/250 (44%), Gaps = 18/250 (7%)
Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNL------KTREGNVRVSRELPGHTGYLSCCR 150
+ W+ C + PSG+ +A D +++L T EG+ R H SC
Sbjct: 394 TDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWH----SCGN 449
Query: 151 FLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKL 210
F + +SS D T +WD+ + + T GH+ V S+ P T ++ + D + +
Sbjct: 450 F-----VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSI 504
Query: 211 WDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNII 270
WD R G+C QS GH+ IN F P G+ A+ +L+D R + L + S D
Sbjct: 505 WDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSIDIGP 562
Query: 271 CGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATG 330
V F SGR+L + ++ D LK L GH+N + + DG + +G
Sbjct: 563 SPGNEVNFDSSGRVLAQASGNGVIHLLD-LKSGEIHKLMGHENEAHTVVFSHDGEILFSG 621
Query: 331 SWDSFLRIWN 340
D +R W+
Sbjct: 622 GSDGTVRTWS 631
Score = 43.9 bits (102), Expect = 2e-04
Identities = 53/250 (21%), Positives = 84/250 (33%), Gaps = 52/250 (20%)
Query: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG 109
T GH +++ W + S+S D IWD + + + V + + P
Sbjct: 431 TFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFS 490
Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALW 169
N + D SI++ +T + L GH ++ F
Sbjct: 491 NTLLTSSADKTLSIWDARTG----ICEQSLYGHMHSINDAIF------------------ 528
Query: 170 DIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDAS--SKLWDIRDGMCRQSFTGHVS 227
D R + +CDA +KLWD R + S S
Sbjct: 529 -------------------------DPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPS 563
Query: 228 DINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLA 287
N V+F +G A S + L DL++ + L H+N +V FS G +L +
Sbjct: 564 PGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHEN---EAHTVVFSHDGEILFS 620
Query: 288 GYDDFNCNVW 297
G D W
Sbjct: 621 GGSDGTVRTW 630
Score = 36.2 bits (82), Expect = 0.043
Identities = 39/184 (21%), Positives = 76/184 (41%), Gaps = 12/184 (6%)
Query: 34 TSNMDSVGRI----QMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNK 89
+S++D +I R R TL GH + ++ + S L+++S D L IWD+ T
Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512
Query: 90 MHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVS-RELPGH-TGYLS 147
++ + + P G+ +A + +++ + V + PG+ + S
Sbjct: 513 EQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDS 572
Query: 148 CCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDAS 207
R L +SG+ L D+++ + GH + ++ S D SG D +
Sbjct: 573 SGRVL-----AQASGNGVIHLLDLKSG-EIHKLMGHENEAHTVVFSHDGEILFSGGSDGT 626
Query: 208 SKLW 211
+ W
Sbjct: 627 VRTW 630
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 95.9 bits (237), Expect = 5e-20
Identities = 71/267 (26%), Positives = 119/267 (44%), Gaps = 15/267 (5%)
Query: 48 RRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAP 107
+R LRGH + + D + +S S DG L +WD T + V++ A++
Sbjct: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115
Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ---IVTSSGDT 164
+ G D ++N G + + + H+ ++SC RF +S IV+ D
Sbjct: 116 DNRQIVSGSRDKTIKLWNTL---GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 165 TCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTG 224
+W++ + T GH+G + ++++SPD SG D + LWD+ +G + G
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232
Query: 225 HVSDINAVSFFPNGYAFATGSDDATCRLFDLRA-------DQELLLYSHDNIICGITSVA 277
INA+ F PN Y + + + +++DL QE++ S TS+A
Sbjct: 233 G-DIINALCFSPNRY-WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290
Query: 278 FSKSGRLLLAGYDDFNCNVWDTLKGDR 304
+S G+ L AGY D VW G R
Sbjct: 291 WSADGQTLFAGYTDNLVRVWQVTIGTR 317
Score = 75.5 bits (184), Expect = 6e-14
Identities = 69/252 (27%), Positives = 107/252 (42%), Gaps = 14/252 (5%)
Query: 97 SSWVMTCAYAPS-GNYVACGGLDNICSIYNLKTREGNVRV-SRELPGHTGYLSCCRFLDD 154
+ WV A P + + D ++ L E N + R L GH+ ++S D
Sbjct: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74
Query: 155 SQIVTS-SGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDI 213
Q S S D T LWD+ T T F GH+ DV+S++ S D R VSG+ D + KLW+
Sbjct: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134
Query: 214 RDGMCRQSF--TGHVSDINAVSFFPNGY--AFATGSDDATCRLFDLRADQELLLYSHDNI 269
G+C+ + H ++ V F PN + D ++++L + L +H
Sbjct: 135 L-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK--LKTNHIGH 191
Query: 270 ICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHD-NRVSCLGVTDDGMAVA 328
+ +V S G L +G D +WD +G L G D C + A
Sbjct: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA 251
Query: 329 TGSWDSFLRIWN 340
TG ++IW+
Sbjct: 252 TG---PSIKIWD 260
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 93.6 bits (231), Expect = 2e-19
Identities = 67/265 (25%), Positives = 109/265 (41%), Gaps = 7/265 (2%)
Query: 76 DGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRV 135
D L++W ++ + V ++PSG+ +A G D I+ + +G V
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTV 60
Query: 136 SRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSP 194
R HT + F D Q VT+S D T +W + + + H V SP
Sbjct: 61 FR---AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117
Query: 195 DMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFD 254
D R VS + D + KLWD C S+ H + V F P+G A D T +++D
Sbjct: 118 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
Query: 255 LRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNR 314
+R + L Y + + ++F SG L+ D + D ++G L GH
Sbjct: 178 VRTHRLLQHYQLHS--AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGP 235
Query: 315 VSCLGVTDDGMAVATGSWDSFLRIW 339
+ + + G A+G D + +W
Sbjct: 236 ATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 89.7 bits (221), Expect = 3e-18
Identities = 60/246 (24%), Positives = 106/246 (43%), Gaps = 7/246 (2%)
Query: 53 GHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYV 112
GH + +++ LL S S+D + IW + ++ V + + G
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 80
Query: 113 ACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWDI 171
D ++ ++ +S+ H ++ C +F D + IV++S D T LWD
Sbjct: 81 VTASDDKTVKVWATHRQKFLFSLSQ----HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 136
Query: 172 ETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINA 231
+ + ++ H G V + P + D + K+WD+R Q + H + +N
Sbjct: 137 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 196
Query: 232 VSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDD 291
+SF P+G T S D+T ++ DL + LLY+ T+VAFS++G +G D
Sbjct: 197 LSFHPSGNYLITASSDSTLKILDLMEGR--LLYTLHGHQGPATTVAFSRTGEYFASGGSD 254
Query: 292 FNCNVW 297
VW
Sbjct: 255 EQVMVW 260
Score = 79.7 bits (195), Expect = 3e-15
Identities = 45/197 (22%), Positives = 87/197 (44%), Gaps = 5/197 (2%)
Query: 52 RGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNY 111
R H A + ++H+ D + V+AS D + +W ++ + ++ +WV ++P G
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSG-DTTCALWD 170
+ D +++ +RE H G+++ F + ++G D T +WD
Sbjct: 122 IVSASDDKTVKLWDKSSRE----CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
Query: 171 IETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDIN 230
+ T + + HS V LS P ++ + D++ K+ D+ +G + GH
Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
Query: 231 AVSFFPNGYAFATGSDD 247
V+F G FA+G D
Sbjct: 238 TVAFSRTGEYFASGGSD 254
Score = 74.3 bits (181), Expect = 1e-13
Identities = 42/178 (23%), Positives = 78/178 (43%), Gaps = 2/178 (1%)
Query: 163 DTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSF 222
D+ +W ++ + FTGH V ++ SP SG+ D + ++W F
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 223 TGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSG 282
H + + +V F +G +F T SDD T +++ ++ L+S I + FS G
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 283 RLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
RL+++ DD +WD + H V+ + G +A D+ +++W+
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
Score = 67.0 bits (162), Expect = 2e-11
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 5/163 (3%)
Query: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG 109
+L H+ + + D RL+VSAS D + +WD + +H+ +V + PSG
Sbjct: 102 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 161
Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRF-LDDSQIVTSSGDTTCAL 168
+A G+DN +++++T R+ + H+ ++ F + ++T+S D+T +
Sbjct: 162 TCIAAAGMDNTVKVWDVRTH----RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
Query: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLW 211
D+ + T GH G +++ S F SG D +W
Sbjct: 218 LDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 93.6 bits (231), Expect = 2e-19
Identities = 81/313 (25%), Positives = 133/313 (42%), Gaps = 30/313 (9%)
Query: 51 LRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKM---------------HAIPL 95
LRGH ++++ W S LL S S D IW+ + H +P
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 96 RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDS 155
V + + G +A G D I+ T GN+ + L H G + ++
Sbjct: 235 NKD-VTSLDWNSDGTLLAMGSYDGFARIW---TENGNL--ASTLGQHKGPIFALKWNKKG 288
Query: 156 QIVTSSG-DTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIR 214
V S+G D T +WD T + F HS + + +M TF S + D + +
Sbjct: 289 NYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNM-TFASCSTDMCIHVCRLG 347
Query: 215 DGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELL-LYSHDNIICGI 273
++F GH +++NA+ + P+G A+ SDD T +++ ++ D + L +H I I
Sbjct: 348 CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTI 407
Query: 274 ----TSVAFSK--SGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAV 327
T A S S +L + D +WD +G L H V + + DG +
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 328 ATGSWDSFLRIWN 340
A+GS+D ++ IWN
Sbjct: 468 ASGSFDKYVHIWN 480
Score = 77.0 bits (188), Expect = 2e-14
Identities = 59/254 (23%), Positives = 103/254 (40%), Gaps = 16/254 (6%)
Query: 58 IYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGL 117
+ ++ W D LL S DG IW N + + + GNYV G+
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWNKKGNYVLSAGV 296
Query: 118 DNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQT 177
D I++ T E ++ P H+ + ++ + S D + +
Sbjct: 297 DKTTIIWDAHTGEAK----QQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPV 352
Query: 178 TTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPN 237
TF GH+ +V ++ P S + D + K+W ++ C H +I + + P
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 238 GYA---------FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAG 288
G A A+ S D+T RL+D+ +Q + ++ + SVAFS G+ L +G
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDV--EQGVCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 289 YDDFNCNVWDTLKG 302
D ++W+T G
Sbjct: 471 SFDKYVHIWNTQSG 484
Score = 74.7 bits (182), Expect = 1e-13
Identities = 65/288 (22%), Positives = 120/288 (41%), Gaps = 26/288 (9%)
Query: 26 NDATLVQITSNMDSVGRIQMRTRR---TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIW 82
+D TL+ + S D RI TL H I+A+ W ++SA D IIW
Sbjct: 245 SDGTLLAMGS-YDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIW 303
Query: 83 DSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGG--LDNICSIYNLKTREGNVRVSRELP 140
D++T P S+ + + + + +C ++C R G +
Sbjct: 304 DAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVC-------RLGCDHPVKTFQ 356
Query: 141 GHTGYLSCCRFLDDSQIVTS-SGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSP----- 194
GHT ++ ++ ++ S S D T +W ++ HS ++ ++ SP
Sbjct: 357 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPAT 416
Query: 195 ----DMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATC 250
S + D++ +LWD+ G+C + H + +V+F P+G A+GS D
Sbjct: 417 SNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYV 476
Query: 251 RLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWD 298
+++ ++ L++S+ GI V ++ G + A D + V D
Sbjct: 477 HIWNTQSGS--LVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCVLD 521
Score = 59.3 bits (142), Expect = 5e-09
Identities = 48/207 (23%), Positives = 77/207 (37%), Gaps = 37/207 (17%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPS 108
+T +GH ++ A+ W LL S S D L IW +H + S + T ++P+
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCAL 168
G T N + + ++S D+T L
Sbjct: 413 GP----------------ATSNPNSSI--------------------MLASASFDSTVRL 436
Query: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSD 228
WD+E T T H V S++ SPD + SG+ D +W+ + G S+ G
Sbjct: 437 WDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGG 495
Query: 229 INAVSFFPNGYAFATGSDDATCRLFDL 255
I V + G + D + + DL
Sbjct: 496 IFEVCWNARGDKVGASASDGSVCVLDL 522
Score = 38.5 bits (88), Expect = 0.009
Identities = 43/220 (19%), Positives = 78/220 (35%), Gaps = 58/220 (26%)
Query: 176 QTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRD---GMCRQSFTGHV------ 226
+ T GH +V + +P SG+ D+++++W++ + G Q H
Sbjct: 171 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 230
Query: 227 -----SDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKS 281
D+ ++ + +G A GS D R++ + L H I ++ ++K
Sbjct: 231 DVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKG---PIFALKWNKK 287
Query: 282 GRLLLAGYDDFNCNVWDTLKGD-----------------------------------RAG 306
G +L+ D +WD G+ R G
Sbjct: 288 GNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLG 347
Query: 307 ------VLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
GH N V+ + GM +A+ S D L+IW+
Sbjct: 348 CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 387
Score = 29.6 bits (65), Expect = 4.0
Identities = 15/38 (39%), Positives = 21/38 (55%)
Query: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
++A VL GH++ V +A+GS DS RIWN
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN 207
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 93.6 bits (231), Expect = 2e-19
Identities = 81/313 (25%), Positives = 133/313 (42%), Gaps = 30/313 (9%)
Query: 51 LRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKM---------------HAIPL 95
LRGH ++++ W S LL S S D IW+ + H +P
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 96 RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDS 155
V + + G +A G D I+ T GN+ + L H G + ++
Sbjct: 235 NKD-VTSLDWNSDGTLLAMGSYDGFARIW---TENGNL--ASTLGQHKGPIFALKWNKKG 288
Query: 156 QIVTSSG-DTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIR 214
V S+G D T +WD T + F HS + + +M TF S + D + +
Sbjct: 289 NYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNM-TFASCSTDMCIHVCRLG 347
Query: 215 DGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELL-LYSHDNIICGI 273
++F GH +++NA+ + P+G A+ SDD T +++ ++ D + L +H I I
Sbjct: 348 CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTI 407
Query: 274 ----TSVAFSK--SGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAV 327
T A S S +L + D +WD +G L H V + + DG +
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 328 ATGSWDSFLRIWN 340
A+GS+D ++ IWN
Sbjct: 468 ASGSFDKYVHIWN 480
Score = 77.0 bits (188), Expect = 2e-14
Identities = 59/254 (23%), Positives = 103/254 (40%), Gaps = 16/254 (6%)
Query: 58 IYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGL 117
+ ++ W D LL S DG IW N + + + GNYV G+
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWNKKGNYVLSAGV 296
Query: 118 DNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQT 177
D I++ T E ++ P H+ + ++ + S D + +
Sbjct: 297 DKTTIIWDAHTGEAK----QQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPV 352
Query: 178 TTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPN 237
TF GH+ +V ++ P S + D + K+W ++ C H +I + + P
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 238 GYA---------FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAG 288
G A A+ S D+T RL+D+ +Q + ++ + SVAFS G+ L +G
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDV--EQGVCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 289 YDDFNCNVWDTLKG 302
D ++W+T G
Sbjct: 471 SFDKYVHIWNTQSG 484
Score = 74.7 bits (182), Expect = 1e-13
Identities = 65/288 (22%), Positives = 120/288 (41%), Gaps = 26/288 (9%)
Query: 26 NDATLVQITSNMDSVGRIQMRTRR---TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIW 82
+D TL+ + S D RI TL H I+A+ W ++SA D IIW
Sbjct: 245 SDGTLLAMGS-YDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIW 303
Query: 83 DSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGG--LDNICSIYNLKTREGNVRVSRELP 140
D++T P S+ + + + + +C ++C R G +
Sbjct: 304 DAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVC-------RLGCDHPVKTFQ 356
Query: 141 GHTGYLSCCRFLDDSQIVTS-SGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSP----- 194
GHT ++ ++ ++ S S D T +W ++ HS ++ ++ SP
Sbjct: 357 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPAT 416
Query: 195 ----DMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATC 250
S + D++ +LWD+ G+C + H + +V+F P+G A+GS D
Sbjct: 417 SNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYV 476
Query: 251 RLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWD 298
+++ ++ L++S+ GI V ++ G + A D + V D
Sbjct: 477 HIWNTQSGS--LVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCVLD 521
Score = 59.3 bits (142), Expect = 5e-09
Identities = 48/207 (23%), Positives = 77/207 (37%), Gaps = 37/207 (17%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPS 108
+T +GH ++ A+ W LL S S D L IW +H + S + T ++P+
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCAL 168
G T N + + ++S D+T L
Sbjct: 413 GP----------------ATSNPNSSI--------------------MLASASFDSTVRL 436
Query: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSD 228
WD+E T T H V S++ SPD + SG+ D +W+ + G S+ G
Sbjct: 437 WDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGG 495
Query: 229 INAVSFFPNGYAFATGSDDATCRLFDL 255
I V + G + D + + DL
Sbjct: 496 IFEVCWNARGDKVGASASDGSVCVLDL 522
Score = 38.5 bits (88), Expect = 0.009
Identities = 43/220 (19%), Positives = 78/220 (35%), Gaps = 58/220 (26%)
Query: 176 QTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRD---GMCRQSFTGHV------ 226
+ T GH +V + +P SG+ D+++++W++ + G Q H
Sbjct: 171 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 230
Query: 227 -----SDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKS 281
D+ ++ + +G A GS D R++ + L H I ++ ++K
Sbjct: 231 DVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKG---PIFALKWNKK 287
Query: 282 GRLLLAGYDDFNCNVWDTLKGD-----------------------------------RAG 306
G +L+ D +WD G+ R G
Sbjct: 288 GNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLG 347
Query: 307 ------VLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
GH N V+ + GM +A+ S D L+IW+
Sbjct: 348 CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 387
Score = 29.6 bits (65), Expect = 4.0
Identities = 15/38 (39%), Positives = 21/38 (55%)
Query: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
++A VL GH++ V +A+GS DS RIWN
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN 207
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 93.6 bits (231), Expect = 2e-19
Identities = 81/313 (25%), Positives = 133/313 (42%), Gaps = 30/313 (9%)
Query: 51 LRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKM---------------HAIPL 95
LRGH ++++ W S LL S S D IW+ + H +P
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 96 RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDS 155
V + + G +A G D I+ T GN+ + L H G + ++
Sbjct: 235 NKD-VTSLDWNSDGTLLAMGSYDGFARIW---TENGNL--ASTLGQHKGPIFALKWNKKG 288
Query: 156 QIVTSSG-DTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIR 214
V S+G D T +WD T + F HS + + +M TF S + D + +
Sbjct: 289 NYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNM-TFASCSTDMCIHVCRLG 347
Query: 215 DGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELL-LYSHDNIICGI 273
++F GH +++NA+ + P+G A+ SDD T +++ ++ D + L +H I I
Sbjct: 348 CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTI 407
Query: 274 ----TSVAFSK--SGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAV 327
T A S S +L + D +WD +G L H V + + DG +
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 328 ATGSWDSFLRIWN 340
A+GS+D ++ IWN
Sbjct: 468 ASGSFDKYVHIWN 480
Score = 77.0 bits (188), Expect = 2e-14
Identities = 59/254 (23%), Positives = 103/254 (40%), Gaps = 16/254 (6%)
Query: 58 IYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGL 117
+ ++ W D LL S DG IW N + + + GNYV G+
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWNKKGNYVLSAGV 296
Query: 118 DNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQT 177
D I++ T E ++ P H+ + ++ + S D + +
Sbjct: 297 DKTTIIWDAHTGEAK----QQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPV 352
Query: 178 TTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPN 237
TF GH+ +V ++ P S + D + K+W ++ C H +I + + P
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 238 GYA---------FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAG 288
G A A+ S D+T RL+D+ +Q + ++ + SVAFS G+ L +G
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDV--EQGVCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 289 YDDFNCNVWDTLKG 302
D ++W+T G
Sbjct: 471 SFDKYVHIWNTQSG 484
Score = 74.7 bits (182), Expect = 1e-13
Identities = 65/288 (22%), Positives = 120/288 (41%), Gaps = 26/288 (9%)
Query: 26 NDATLVQITSNMDSVGRIQMRTRR---TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIW 82
+D TL+ + S D RI TL H I+A+ W ++SA D IIW
Sbjct: 245 SDGTLLAMGS-YDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIW 303
Query: 83 DSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGG--LDNICSIYNLKTREGNVRVSRELP 140
D++T P S+ + + + + +C ++C R G +
Sbjct: 304 DAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVC-------RLGCDHPVKTFQ 356
Query: 141 GHTGYLSCCRFLDDSQIVTS-SGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSP----- 194
GHT ++ ++ ++ S S D T +W ++ HS ++ ++ SP
Sbjct: 357 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPAT 416
Query: 195 ----DMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATC 250
S + D++ +LWD+ G+C + H + +V+F P+G A+GS D
Sbjct: 417 SNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYV 476
Query: 251 RLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWD 298
+++ ++ L++S+ GI V ++ G + A D + V D
Sbjct: 477 HIWNTQSGS--LVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCVLD 521
Score = 59.3 bits (142), Expect = 5e-09
Identities = 48/207 (23%), Positives = 77/207 (37%), Gaps = 37/207 (17%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPS 108
+T +GH ++ A+ W LL S S D L IW +H + S + T ++P+
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCAL 168
G T N + + ++S D+T L
Sbjct: 413 GP----------------ATSNPNSSI--------------------MLASASFDSTVRL 436
Query: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSD 228
WD+E T T H V S++ SPD + SG+ D +W+ + G S+ G
Sbjct: 437 WDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGG 495
Query: 229 INAVSFFPNGYAFATGSDDATCRLFDL 255
I V + G + D + + DL
Sbjct: 496 IFEVCWNARGDKVGASASDGSVCVLDL 522
Score = 38.5 bits (88), Expect = 0.009
Identities = 43/220 (19%), Positives = 78/220 (35%), Gaps = 58/220 (26%)
Query: 176 QTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRD---GMCRQSFTGHV------ 226
+ T GH +V + +P SG+ D+++++W++ + G Q H
Sbjct: 171 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 230
Query: 227 -----SDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKS 281
D+ ++ + +G A GS D R++ + L H I ++ ++K
Sbjct: 231 DVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKG---PIFALKWNKK 287
Query: 282 GRLLLAGYDDFNCNVWDTLKGD-----------------------------------RAG 306
G +L+ D +WD G+ R G
Sbjct: 288 GNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLG 347
Query: 307 ------VLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
GH N V+ + GM +A+ S D L+IW+
Sbjct: 348 CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 387
Score = 29.6 bits (65), Expect = 4.0
Identities = 15/38 (39%), Positives = 21/38 (55%)
Query: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
++A VL GH++ V +A+GS DS RIWN
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN 207
>gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]
Length = 919
Score = 93.2 bits (230), Expect = 3e-19
Identities = 55/181 (30%), Positives = 84/181 (46%), Gaps = 2/181 (1%)
Query: 161 SGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQ 220
SG +W+ ++ GH +++L+ SPD + V+G D K+W+ G C
Sbjct: 350 SGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFV 409
Query: 221 SFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSK 280
+FT H S + V+F GY T S D T R FDL + ++ + VA
Sbjct: 410 TFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPR-PTQFSCVAVDA 468
Query: 281 SGRLLLAG-YDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
SG ++ AG D F VW G VL+GH+ +S L +A+ SWD +R+W
Sbjct: 469 SGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLW 528
Query: 340 N 340
+
Sbjct: 529 D 529
Score = 66.2 bits (160), Expect = 4e-11
Identities = 58/257 (22%), Positives = 102/257 (39%), Gaps = 23/257 (8%)
Query: 52 RGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNY 111
+GH + A+ + D + +V+ DGK+ +W++ + SS V + +G
Sbjct: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCAL--W 169
V +D ++L R N R P T + SC +IV++ + + W
Sbjct: 430 VVTSSMDGTVRAFDLH-RYRNFRTFTS-PRPTQF-SCVAVDASGEIVSAGAQDSFEIFVW 486
Query: 170 DIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDI 229
++T + +GH G + L +P S + D + +LWD+ D + SD
Sbjct: 487 SMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDA 546
Query: 230 NAVSFFPNGYAFA------------------TGSDDATCRLFDLRADQELLLYSHDNIIC 271
AV+F P+G A TGS + L R + + + H
Sbjct: 547 LAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGK 606
Query: 272 GITSVAFSKSGRLLLAG 288
T++ +S G +LAG
Sbjct: 607 AFTALCYSADGHSILAG 623
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 92.8 bits (229), Expect = 4e-19
Identities = 68/240 (28%), Positives = 102/240 (42%), Gaps = 8/240 (3%)
Query: 54 HLAKIYAMHWGYDS-RLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYV 112
H + + ++ G S RLL + D ++ +W N + ++ +S V + +
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 113 ACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTS-SGDTTCALWDI 171
G +++L+ ++ R L GH + F + V S S DT LWDI
Sbjct: 79 VAGSQSGSIRVWDLEA----AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDI 134
Query: 172 ETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINA 231
+ GHS V L SPD + S A D + KLWD+ G F GH +N
Sbjct: 135 RRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNV 194
Query: 232 VSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDD 291
V F PN Y A+GS D T R +DL Q + + + SV F+ G L +G D
Sbjct: 195 VEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEP--GPVRSVLFNPDGCCLYSGCQD 252
Score = 90.1 bits (222), Expect = 3e-18
Identities = 68/233 (29%), Positives = 102/233 (43%), Gaps = 8/233 (3%)
Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRF-LDDSQIVTSSGDTTC 166
SG +A GG D C + + N +S L GHT + R + IV S +
Sbjct: 32 SGRLLATGGDD--CRVNLWSINKPNCIMS--LTGHTSPVESVRLNTPEELIVAGSQSGSI 87
Query: 167 ALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHV 226
+WD+E A+ T GH ++ SL P SG+ D + KLWDIR C + GH
Sbjct: 88 RVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHS 147
Query: 227 SDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLL 286
+ + F P+G A+ +DD T +L+DL A + ++ + V F + LL
Sbjct: 148 QAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK--MMSEFPGHTGPVNVVEFHPNEYLLA 205
Query: 287 AGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
+G D WD K + G V + DG + +G DS LR++
Sbjct: 206 SGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS-LRVY 257
Score = 86.3 bits (212), Expect = 4e-17
Identities = 50/200 (25%), Positives = 92/200 (46%), Gaps = 5/200 (2%)
Query: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG 109
+L GH + + ++ L+V+ SQ G + +WD + + + + + + P G
Sbjct: 58 SLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG 117
Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDT-TCAL 168
+VA G D +++++ R+G V R GH+ + C RF D + + S+ D T L
Sbjct: 118 EFVASGSQDTNIKLWDIR-RKGCVFRYR---GHSQAVRCLRFSPDGKWLASAADDHTVKL 173
Query: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSD 228
WD+ + + F GH+G V + P+ SG+ D + + WD+ G
Sbjct: 174 WDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGP 233
Query: 229 INAVSFFPNGYAFATGSDDA 248
+ +V F P+G +G D+
Sbjct: 234 VRSVLFNPDGCCLYSGCQDS 253
Score = 84.0 bits (206), Expect = 2e-16
Identities = 49/185 (26%), Positives = 82/185 (44%), Gaps = 4/185 (2%)
Query: 157 IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDG 216
+ T D LW I + TGH+ V S+ L+ V+G+ S ++WD+
Sbjct: 36 LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95
Query: 217 MCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLY-SHDNIICGITS 275
++ GH ++I ++ F P G A+GS D +L+D+R + Y H +
Sbjct: 96 KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQ---AVRC 152
Query: 276 VAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
+ FS G+ L + DD +WD G GH V+ + + +A+GS D
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
Query: 336 LRIWN 340
+R W+
Sbjct: 213 IRFWD 217
Score = 71.2 bits (173), Expect = 1e-12
Identities = 49/171 (28%), Positives = 73/171 (42%), Gaps = 5/171 (2%)
Query: 172 ETAQQTTTFTGHSGDVMSLSLSPDM-RTFVSGACDASSKLWDIRDGMCRQSFTGHVSDIN 230
+TA + H+ +V SL L R +G D LW I C S TGH S +
Sbjct: 8 KTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVE 67
Query: 231 AVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICGITSVAFSKSGRLLLAGY 289
+V GS + R++DL A + L L H IC S+ F G + +G
Sbjct: 68 SVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANIC---SLDFHPYGEFVASGS 124
Query: 290 DDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
D N +WD + GH V CL + DG +A+ + D +++W+
Sbjct: 125 QDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWD 175
Score = 67.8 bits (164), Expect = 1e-11
Identities = 44/159 (27%), Positives = 71/159 (44%), Gaps = 5/159 (3%)
Query: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPS 108
RTL GH A I ++ + + S SQD + +WD + S V ++P
Sbjct: 99 RTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPD 158
Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTS-SGDTTCA 167
G ++A D+ +++L ++ E PGHTG ++ F + ++ S S D T
Sbjct: 159 GKWLASAADDHTVKLWDLTAG----KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIR 214
Query: 168 LWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDA 206
WD+E Q + G G V S+ +PD SG D+
Sbjct: 215 FWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.133 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,377,651
Number of Sequences: 37866
Number of extensions: 514023
Number of successful extensions: 4765
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 240
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 1660
Number of HSP's gapped (non-prelim): 1525
length of query: 340
length of database: 18,247,518
effective HSP length: 103
effective length of query: 237
effective length of database: 14,347,320
effective search space: 3400314840
effective search space used: 3400314840
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.