Guide to the Human Genome
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Search of human proteins with 156523968

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|156523968 poly (ADP-ribose) polymerase family, member 1
[Homo sapiens]
         (1014 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|156523968 poly (ADP-ribose) polymerase family, member 1 [Homo...  2028   0.0  
gi|110825963 poly (ADP-ribose) polymerase family, member 2 isofo...   386   e-107
gi|110825961 poly (ADP-ribose) polymerase family, member 2 isofo...   386   e-107
gi|158634482 poly (ADP-ribose) polymerase family, member 3 isofo...   244   3e-64
gi|158634478 poly (ADP-ribose) polymerase family, member 3 isofo...   244   3e-64
gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo...   114   4e-25
gi|73747844 ligase III, DNA, ATP-dependent isoform beta precurso...    54   7e-07
gi|73747829 ligase III, DNA, ATP-dependent isoform alpha precurs...    54   7e-07
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    46   2e-04
gi|194440660 topoisomerase (DNA) II binding protein 1 [Homo sapi...    43   0.001
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    40   0.009
gi|13124883 HsKin17 protein [Homo sapiens]                             39   0.019
gi|32528306 replication factor C large subunit [Homo sapiens]          39   0.032
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ...    39   0.032
gi|7657218 bromodomain-containing protein 4 isoform short [Homo ...    38   0.055
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...    38   0.055
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    37   0.094
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]    37   0.094
gi|115527120 nebulin [Homo sapiens]                                    37   0.094
gi|94536838 poly (ADP-ribose) polymerase family, member 6 [Homo ...    37   0.12 
gi|24432009 poly (ADP-ribose) polymerase family, member 8 [Homo ...    36   0.16 
gi|239757817 PREDICTED: similar to hCG1647425 [Homo sapiens]           36   0.21 
gi|10190716 spindle pole body component 25 [Homo sapiens]              35   0.27 
gi|237858621 polyamine modulated factor 1 binding protein 1 isof...    35   0.36 
gi|237858619 polyamine modulated factor 1 binding protein 1 isof...    35   0.36 
gi|38788333 remodeling and spacing factor 1 [Homo sapiens]             35   0.47 
gi|51317384 GLE1 RNA export mediator homolog isoform 1 [Homo sap...    34   0.61 
gi|4557627 GLE1 RNA export mediator homolog isoform 2 [Homo sapi...    34   0.61 
gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens]             34   0.80 
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]             34   0.80 

>gi|156523968 poly (ADP-ribose) polymerase family, member 1 [Homo
            sapiens]
          Length = 1014

 Score = 2028 bits (5254), Expect = 0.0
 Identities = 1014/1014 (100%), Positives = 1014/1014 (100%)

Query: 1    MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV 60
            MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV
Sbjct: 1    MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV 60

Query: 61   GHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKS 120
            GHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKS
Sbjct: 61   GHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKS 120

Query: 121  NRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ 180
            NRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ
Sbjct: 121  NRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ 180

Query: 181  LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKA 240
            LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKA
Sbjct: 181  LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKA 240

Query: 241  QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSG 300
            QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSG
Sbjct: 241  QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSG 300

Query: 301  QLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE 360
            QLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE
Sbjct: 301  QLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE 360

Query: 361  TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT 420
            TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT
Sbjct: 361  TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT 420

Query: 421  GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSP 480
            GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSP
Sbjct: 421  GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSP 480

Query: 481  WGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE 540
            WGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE
Sbjct: 481  WGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE 540

Query: 541  HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNK 600
            HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNK
Sbjct: 541  HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNK 600

Query: 601  LEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPG 660
            LEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPG
Sbjct: 601  LEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPG 660

Query: 661  TKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAV 720
            TKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAV
Sbjct: 661  TKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAV 720

Query: 721  SQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRG 780
            SQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRG
Sbjct: 721  SQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRG 780

Query: 781  GSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE 840
            GSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE
Sbjct: 781  GSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE 840

Query: 841  REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM 900
            REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM
Sbjct: 841  REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM 900

Query: 901  VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSA 960
            VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSA
Sbjct: 901  VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSA 960

Query: 961  NISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 1014
            NISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
Sbjct: 961  NISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 1014


>gi|110825963 poly (ADP-ribose) polymerase family, member 2 isoform 2
            [Homo sapiens]
          Length = 570

 Score =  386 bits (991), Expect = e-107
 Identities = 216/516 (41%), Positives = 323/516 (62%), Gaps = 17/516 (3%)

Query: 512  KEEGINKSEKRMK-LTLKGGAAVDPDSGLE-HSAHVLEKGGKVFSATLGLVDIVKGTNSY 569
            K+   +K ++ +K L LKG A VDP+   +   AHV  +G  V+   L   ++    N Y
Sbjct: 59   KDRTEDKQDESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKY 118

Query: 570  YKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSK 629
            Y +QLLEDD +  + ++  WGRVG +   + +    +   A E F K + +KT N W  +
Sbjct: 119  YLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDR 178

Query: 630  N-FTKYPKKFYPLEIDYG---QDEEAVKK---LTVNPGTKSKLPKPVQDLIKMIFDVESM 682
              F K P K+  L++DY    QDEE  KK   L      +S+L   VQ+LIK+I +V++M
Sbjct: 179  EKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAM 238

Query: 683  KKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPH 742
            ++ M+E + + +K PLGKL+  QI+A Y  L +++  +  G     +++  N FYT IPH
Sbjct: 239  EEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPH 298

Query: 743  DFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIK 802
            DFG++ PPL+     +  K+++L+ L DIE+A  L++     S + P+D +Y  L   ++
Sbjct: 299  DFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQ-SPEHPLDQHYRNLHCALR 357

Query: 803  VVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWH 862
             +D +S E ++I +Y+++THA TH+ Y + ++D+F++E++GE + ++  + LHNR LLWH
Sbjct: 358  PLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFR--EDLHNRMLLWH 415

Query: 863  GSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLG 922
            GSR +N+ GILS GLRIAPPEAP+TGYMFGKGIYFADM SKSANYC  S+    GL+LL 
Sbjct: 416  GSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLS 475

Query: 923  EVALGNMYELKHASHISK-LPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGV-- 979
            EVALG   EL  A+  ++ L +GKHS KGLGK  P  +  ++L+G  VPLG    +G+  
Sbjct: 476  EVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILN 535

Query: 980  -NDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 1014
             +  +L YNEYIVY+  QV ++YLLK++FNF   LW
Sbjct: 536  PDGYTLNYNEYIVYNPNQVRMRYLLKVQFNF-LQLW 570


>gi|110825961 poly (ADP-ribose) polymerase family, member 2 isoform 1
            [Homo sapiens]
          Length = 583

 Score =  386 bits (991), Expect = e-107
 Identities = 215/508 (42%), Positives = 317/508 (62%), Gaps = 16/508 (3%)

Query: 519  SEKRMKLTLKGGAAVDPDSGLE-HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLED 577
            SE    L LKG A VDP+   +   AHV  +G  V+   L   ++    N YY +QLLED
Sbjct: 80   SESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLED 139

Query: 578  DKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN-FTKYPK 636
            D +  + ++  WGRVG +   + +    +   A E F K + +KT N W  +  F K P 
Sbjct: 140  DAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREKFEKVPG 199

Query: 637  KFYPLEIDYG---QDEEAVKK---LTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYE 690
            K+  L++DY    QDEE  KK   L      +S+L   VQ+LIK+I +V++M++ M+E +
Sbjct: 200  KYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEEMMMEMK 259

Query: 691  IDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPP 750
             + +K PLGKL+  QI+A Y  L +++  +  G     +++  N FYT IPHDFG++ PP
Sbjct: 260  YNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPP 319

Query: 751  LLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEE 810
            L+     +  K+++L+ L DIE+A  L++     S + P+D +Y  L   ++ +D +S E
Sbjct: 320  LIRTQKELSEKIQLLEALGDIEIAIKLVKTELQ-SPEHPLDQHYRNLHCALRPLDHESYE 378

Query: 811  AEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFA 870
             ++I +Y+++THA TH+ Y + ++D+F++E++GE + ++  + LHNR LLWHGSR +N+ 
Sbjct: 379  FKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFR--EDLHNRMLLWHGSRMSNWV 436

Query: 871  GILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMY 930
            GILS GLRIAPPEAP+TGYMFGKGIYFADM SKSANYC  S+    GL+LL EVALG   
Sbjct: 437  GILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCN 496

Query: 931  ELKHASHISK-LPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGV---NDTSLLY 986
            EL  A+  ++ L +GKHS KGLGK  P  +  ++L+G  VPLG    +G+   +  +L Y
Sbjct: 497  ELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNY 556

Query: 987  NEYIVYDIAQVNLKYLLKLKFNFKTSLW 1014
            NEYIVY+  QV ++YLLK++FNF   LW
Sbjct: 557  NEYIVYNPNQVRMRYLLKVQFNF-LQLW 583


>gi|158634482 poly (ADP-ribose) polymerase family, member 3 isoform b
            [Homo sapiens]
          Length = 533

 Score =  244 bits (623), Expect = 3e-64
 Identities = 168/476 (35%), Positives = 263/476 (55%), Gaps = 33/476 (6%)

Query: 553  FSATLGLVDIVKGTNSYYKLQLLEDDKENRYWI-FRSWGRVGTVIGSNKLEQMPSKEDAI 611
            ++ TL   +I    N +Y +QLL+D   NR++  +  WGRVG V G +K+      EDA 
Sbjct: 66   YNCTLNQTNIENNNNKFYIIQLLQDS--NRFFTCWNHWGRVGEV-GQSKINHFTRLEDAK 122

Query: 612  EHFMKLYEEKTGNAWHSKN-FTKYPKKFYPLEIDYGQD-EEAVKKLTVNP-GTKSKLPKP 668
            + F K + EKT N W  ++ F  +P K+  +E+    + +EAV K+   P  T +K  +P
Sbjct: 123  KDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQP 182

Query: 669  ------VQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQ 722
                   Q LI  IF  E  K  M   ++D++KMPLGKLSK+QI   +  L  +++A+  
Sbjct: 183  CSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKG 242

Query: 723  GSSDSQILD-LSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGG 781
             +   Q L+ LS+ FYT+IPH+FG  +PP +N+ + +QAK +ML  L DIE+A +L    
Sbjct: 243  PTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVS 302

Query: 782  SDDSSKD----PIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIF 837
              + + +    P+D +Y+ LK  ++++D  + E ++I+ Y++ T  + H    L+   I+
Sbjct: 303  EQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQT-GSNHRCPTLQ--HIW 359

Query: 838  KIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYF 897
            K+ +EGE  R++   +L NR+LLWHG+     A IL+ GLRI P     +G   GKGIYF
Sbjct: 360  KVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPH----SGGRVGKGIYF 415

Query: 898  ADMVSKSANYCHTSQ--GDPIGLILLGEVALGNMYELKHAS-HISKLPKGKHSVKGLGKT 954
            A   SKSA Y    +     +G + LGEVALG  + +   +  +   P G  SV   G T
Sbjct: 416  ASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHT 475

Query: 955  TPDPS--ANISLDG--VDVPLGTGI-SSGVNDTSLLYNEYIVYDIAQVNLKYLLKL 1005
             PDP+    + LDG  V VP G  +     + ++   +EY++Y  +Q  L+YLL++
Sbjct: 476  EPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEV 531


>gi|158634478 poly (ADP-ribose) polymerase family, member 3 isoform a
            [Homo sapiens]
          Length = 540

 Score =  244 bits (623), Expect = 3e-64
 Identities = 168/476 (35%), Positives = 263/476 (55%), Gaps = 33/476 (6%)

Query: 553  FSATLGLVDIVKGTNSYYKLQLLEDDKENRYWI-FRSWGRVGTVIGSNKLEQMPSKEDAI 611
            ++ TL   +I    N +Y +QLL+D   NR++  +  WGRVG V G +K+      EDA 
Sbjct: 73   YNCTLNQTNIENNNNKFYIIQLLQDS--NRFFTCWNHWGRVGEV-GQSKINHFTRLEDAK 129

Query: 612  EHFMKLYEEKTGNAWHSKN-FTKYPKKFYPLEIDYGQD-EEAVKKLTVNP-GTKSKLPKP 668
            + F K + EKT N W  ++ F  +P K+  +E+    + +EAV K+   P  T +K  +P
Sbjct: 130  KDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQP 189

Query: 669  ------VQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQ 722
                   Q LI  IF  E  K  M   ++D++KMPLGKLSK+QI   +  L  +++A+  
Sbjct: 190  CSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKG 249

Query: 723  GSSDSQILD-LSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGG 781
             +   Q L+ LS+ FYT+IPH+FG  +PP +N+ + +QAK +ML  L DIE+A +L    
Sbjct: 250  PTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVS 309

Query: 782  SDDSSKD----PIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIF 837
              + + +    P+D +Y+ LK  ++++D  + E ++I+ Y++ T  + H    L+   I+
Sbjct: 310  EQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQT-GSNHRCPTLQ--HIW 366

Query: 838  KIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYF 897
            K+ +EGE  R++   +L NR+LLWHG+     A IL+ GLRI P     +G   GKGIYF
Sbjct: 367  KVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPH----SGGRVGKGIYF 422

Query: 898  ADMVSKSANYCHTSQ--GDPIGLILLGEVALGNMYELKHAS-HISKLPKGKHSVKGLGKT 954
            A   SKSA Y    +     +G + LGEVALG  + +   +  +   P G  SV   G T
Sbjct: 423  ASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHT 482

Query: 955  TPDPS--ANISLDG--VDVPLGTGI-SSGVNDTSLLYNEYIVYDIAQVNLKYLLKL 1005
             PDP+    + LDG  V VP G  +     + ++   +EY++Y  +Q  L+YLL++
Sbjct: 483  EPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEV 538


>gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo
            sapiens]
          Length = 1724

 Score =  114 bits (286), Expect = 4e-25
 Identities = 149/621 (23%), Positives = 257/621 (41%), Gaps = 97/621 (15%)

Query: 403  RNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDV 462
            + K +++  I++ GGK + + N     I           ++  +++ ++ + + DF+   
Sbjct: 21   QQKKKLQTDIKENGGKFSFSLNPQCTHIILDNADVLSQYQLNSIQKNHVHIANPDFIW-- 78

Query: 463  SASTKSLQELFLAHILS--PWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGI---- 516
                KS++E  L  + +  P+      +P+++  P  +      K S  +VK EG+    
Sbjct: 79   ----KSIREKRLLDVKNYDPY------KPLDITPPPDQ------KASSSEVKTEGLCPDS 122

Query: 517  -NKSEKRMKLTLKGGAAVD----PDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYK 571
              + E  ++LT  G   V+    P        + LEK G        +V+          
Sbjct: 123  ATEEEDTVELTEFGMQNVEIPHLPQDFEVAKYNTLEKVGMEGGQEAVVVE---------- 172

Query: 572  LQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNF 631
            LQ   D ++  + I   +     +    +     + EDA E+F    EE     +  +  
Sbjct: 173  LQCSRDSRDCPFLISSHFLLDDGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLR-- 230

Query: 632  TKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEI 691
                + F P E      E+    L       S L + V DL++MI+      +A+   E 
Sbjct: 231  ----EHFTP-EATQLASEQLQALLLEEVMNSSTLSQEVSDLVEMIW-----AEALGHLEH 280

Query: 692  DLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPL 751
             L K P+ ++S   +  A  IL  V+ A+  G +  Q+  +   FY LIPH   M K   
Sbjct: 281  MLLK-PVNRISLNDVSKAEGILLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEV- 338

Query: 752  LNNADSVQAKVEMLDNLLD-IEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEE 810
              N   +  K ++   + D + V  + L          P    Y  L+  I+ V++++EE
Sbjct: 339  --NLGLLAKKADLCQLIRDMVNVCETNL-----SKPNPPSLAKYRALRCKIEHVEQNTEE 391

Query: 811  AEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFA 870
               +RK V   H   H+   ++V+ IF++ R  E   +    +L N R L HGS   N  
Sbjct: 392  FLRVRKEVLQNH---HSKSPVDVLQIFRVGRVNETTEF--LSKLGNVRPLLHGSPVQNIV 446

Query: 871  GILSQGLRIAPPEAPVTGYM------FGKGIYFADMVSKSANYCHTSQGDPIGLILLGEV 924
            GIL +GL + P      G         G GIYF+D +S S  Y H  + D   L+L+ +V
Sbjct: 447  GILCRGL-LLPKVVEDRGVQRTDVGNLGSGIYFSDSLSTSIKYSHPGETDGTRLLLICDV 505

Query: 925  ALGNMYELKHAS-HISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTS 983
            ALG   +L      +++ P G  SV G+ +T     A+++ D  D               
Sbjct: 506  ALGKCMDLHEKDFSLTEAPPGYDSVHGVSQT-----ASVTTDFED--------------- 545

Query: 984  LLYNEYIVYDIAQVNLKYLLK 1004
               +E++VY   QV +KY++K
Sbjct: 546  ---DEFVVYKTNQVKMKYIIK 563


>gi|73747844 ligase III, DNA, ATP-dependent isoform beta precursor
           [Homo sapiens]
          Length = 949

 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 29/111 (26%), Positives = 53/111 (47%), Gaps = 3/111 (2%)

Query: 3   ESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFD--GKVPHWYHFSCFWKV 60
           E +++ + V+YAK G A CKKC E I K   R+  +V +P  +  G +  WYH  C ++ 
Sbjct: 87  EMAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEK 146

Query: 61  GHSIRHPDVEVDGFSELR-WDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTL 110
               R    +++  +EL  W++ +  +K      +        G+  +K +
Sbjct: 147 LERARATTKKIEDLTELEGWEELEDNEKEQITQHIADLSSKAAGTPKKKAV 197



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 27/95 (28%), Positives = 45/95 (47%), Gaps = 2/95 (2%)

Query: 113 FAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVK--NREEL 170
           F  +YAK   + CK C EKI KG  R+ K + +P     G +  WYH  C  +   R   
Sbjct: 93  FCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARA 152

Query: 171 GFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSE 205
             +     ++L+G+  L   +KE + + +  + S+
Sbjct: 153 TTKKIEDLTELEGWEELEDNEKEQITQHIADLSSK 187


>gi|73747829 ligase III, DNA, ATP-dependent isoform alpha precursor
           [Homo sapiens]
          Length = 1009

 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 29/111 (26%), Positives = 53/111 (47%), Gaps = 3/111 (2%)

Query: 3   ESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFD--GKVPHWYHFSCFWKV 60
           E +++ + V+YAK G A CKKC E I K   R+  +V +P  +  G +  WYH  C ++ 
Sbjct: 87  EMAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEK 146

Query: 61  GHSIRHPDVEVDGFSELR-WDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTL 110
               R    +++  +EL  W++ +  +K      +        G+  +K +
Sbjct: 147 LERARATTKKIEDLTELEGWEELEDNEKEQITQHIADLSSKAAGTPKKKAV 197



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 27/95 (28%), Positives = 45/95 (47%), Gaps = 2/95 (2%)

Query: 113 FAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVK--NREEL 170
           F  +YAK   + CK C EKI KG  R+ K + +P     G +  WYH  C  +   R   
Sbjct: 93  FCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARA 152

Query: 171 GFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSE 205
             +     ++L+G+  L   +KE + + +  + S+
Sbjct: 153 TTKKIEDLTELEGWEELEDNEKEQITQHIADLSSK 187


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase [Homo sapiens]
          Length = 1327

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 63/237 (26%), Positives = 87/237 (36%), Gaps = 57/237 (24%)

Query: 792  VNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDL----EVIDIFKIE----REG 843
            VN   +  D+   D++ +  E   +     H    NA  +     VI I K+     RE 
Sbjct: 1102 VNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRER 1161

Query: 844  ECQRYKPFKQL----HNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFAD 899
             C R K   +     HN R+L+HGS   N   I+ +G           G MFG GIYFA+
Sbjct: 1162 FCHRQKEVSEENHNHHNERMLFHGSPFIN--AIIHKGF---DERHAYIGGMFGAGIYFAE 1216

Query: 900  MVSKSANY---------CHTSQGDPIGL----ILLGEVALGNMYELKHASHISKLPKGKH 946
              SKS  Y         C T +     +    +L   V LG  +       ++  P G H
Sbjct: 1217 NSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHH 1276

Query: 947  SVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLL 1003
            SV G       PS N                      L Y EY++Y   Q   +YL+
Sbjct: 1277 SVIG------RPSVN---------------------GLAYAEYVIYRGEQAYPEYLI 1306


>gi|194440660 topoisomerase (DNA) II binding protein 1 [Homo
           sapiens]
          Length = 1522

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 61/302 (20%), Positives = 116/302 (38%), Gaps = 26/302 (8%)

Query: 193 EALKK-QLPGVKS----EGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWN 247
           EA KK  LP V      E  R G   D    + +  +K+E+  ++++   +   +D   +
Sbjct: 706 EAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEH 765

Query: 248 ----IKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCE-----EC 298
               ++   K V +  D+     F  +   +  S    +VA     G  L  E     + 
Sbjct: 766 PGTRLQTHRKTVVTPLDMNR---FQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDT 822

Query: 299 SGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFP 358
             + + K   +  + DV      +   +TP R    + ++ +  + L ++ VK       
Sbjct: 823 PSKFLSKDKLFKPSFDVK---DALAALETPGRP---SQQKRKPSTPLSEVIVKNLQLALA 876

Query: 359 PETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGK 418
             +  +VA +  P    A +       A KPL  + +    KLS+ + E+  +   LG  
Sbjct: 877 NSSRNAVALSASPQLKEAQS---EKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGAD 933

Query: 419 LTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHIL 478
              + ++       +      N++ + VKE  + +VSE +L D +   K L E    H  
Sbjct: 934 YRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTY 993

Query: 479 SP 480
           +P
Sbjct: 994 NP 995


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 40.4 bits (93), Expect = 0.009
 Identities = 35/108 (32%), Positives = 46/108 (42%), Gaps = 18/108 (16%)

Query: 856  NRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCH---TSQ 912
            N R+L+HGS   N   I+ +G           G MFG GIYFA+  SKS  Y +      
Sbjct: 1025 NERMLFHGSPFVN--AIIHKGF---DERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGT 1079

Query: 913  GDPI----------GLILLGEVALGNMYELKHASHISKLPKGKHSVKG 950
            G P+            +L   V LG  +    A  ++  P G HSV G
Sbjct: 1080 GCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTG 1127


>gi|13124883 HsKin17 protein [Homo sapiens]
          Length = 393

 Score = 39.3 bits (90), Expect = 0.019
 Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 6/113 (5%)

Query: 59  KVGHSIRHPDVEVDGFSEL-RWDDQQKV-----KKTAEAGGVTGKGQDGIGSKAEKTLGD 112
           +V   +   + EV  F+EL R +D++KV     K    + G T      +G  A KT+G 
Sbjct: 176 QVRRGLEGKEQEVPTFTELSRENDEEKVTFNLSKGACSSSGATSSKSSTLGPSALKTIGS 235

Query: 113 FAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVK 165
            A+   K +  +     EK +K         ++ EK +    D W  P   VK
Sbjct: 236 SASVKRKESSQSSTQSKEKKKKKSALDEIMEIEEEKKRTARTDYWLQPEIIVK 288


>gi|32528306 replication factor C large subunit [Homo sapiens]
          Length = 1147

 Score = 38.5 bits (88), Expect = 0.032
 Identities = 53/241 (21%), Positives = 97/241 (40%), Gaps = 29/241 (12%)

Query: 313 GDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKK---LKVKKQDRIFPPETSASVA--- 366
           G+V++  K   K     RKE  + KE   ++  +K   +K+K + +  P +T +S A   
Sbjct: 308 GEVSS-PKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKT-PKKTKSSPAKKE 365

Query: 367 -ATPPPS--------------TASAPAAVNSSA---SADKPLSNMKILTLGKL-SRNKDE 407
             +P  S                  P A+ S      A+  L  +  +  G L S  +DE
Sbjct: 366 SVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDE 425

Query: 408 VKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTK 467
            K++IE+ GGK+TG  +K +  +   +  +    K ++      +++ ED L ++  +  
Sbjct: 426 AKSLIERYGGKVTGNVSKKTNYLVMGR--DSGQSKSDKAAALGTKIIDEDGLLNLIRTMP 483

Query: 468 SLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTL 527
             +  +   + +    E K E       +GK   + SKK     K    +K +   K   
Sbjct: 484 GKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIK 543

Query: 528 K 528
           K
Sbjct: 544 K 544


>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
           sapiens]
          Length = 956

 Score = 38.5 bits (88), Expect = 0.032
 Identities = 29/91 (31%), Positives = 43/91 (47%), Gaps = 3/91 (3%)

Query: 146 PEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSE 205
           P    L  I + +  G   KN+  L    E    QLK       E+KE LK++    K E
Sbjct: 313 PTSTPLRRITKKFVKGSTEKNKLRLQRDQERLGKQLK--LRAEREEKEKLKEEAKRAKEE 370

Query: 206 GKRKGDEVDGVDEVAKKKSKKEKDKDSKLEK 236
            K+K +E   + E  +++ K+EKD+  K EK
Sbjct: 371 AKKKKEEEKELKE-KERREKREKDEKEKAEK 400


>gi|7657218 bromodomain-containing protein 4 isoform short [Homo
           sapiens]
          Length = 722

 Score = 37.7 bits (86), Expect = 0.055
 Identities = 32/126 (25%), Positives = 58/126 (46%), Gaps = 13/126 (10%)

Query: 336 PKEFREISYLKKLK-------VKKQDRIFPPETSASVAATPPPSTASAP-----AAVNSS 383
           P +   ++  +KL+        K  D    P  + S  A PPP+   AP     ++ +SS
Sbjct: 434 PPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSS 493

Query: 384 ASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEK-MNKK 442
           + +D    + +     +L+  ++++KA+ E+L        NK       KKE +K  +K+
Sbjct: 494 SDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKR 553

Query: 443 MEEVKE 448
            EEV+E
Sbjct: 554 KEEVEE 559


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
           sapiens]
          Length = 1362

 Score = 37.7 bits (86), Expect = 0.055
 Identities = 32/126 (25%), Positives = 58/126 (46%), Gaps = 13/126 (10%)

Query: 336 PKEFREISYLKKLK-------VKKQDRIFPPETSASVAATPPPSTASAP-----AAVNSS 383
           P +   ++  +KL+        K  D    P  + S  A PPP+   AP     ++ +SS
Sbjct: 434 PPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSS 493

Query: 384 ASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEK-MNKK 442
           + +D    + +     +L+  ++++KA+ E+L        NK       KKE +K  +K+
Sbjct: 494 SDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKR 553

Query: 443 MEEVKE 448
            EEV+E
Sbjct: 554 KEEVEE 559


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
           sapiens]
          Length = 1116

 Score = 37.0 bits (84), Expect = 0.094
 Identities = 23/74 (31%), Positives = 42/74 (56%), Gaps = 5/74 (6%)

Query: 195 LKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSK---LEKALKAQNDLIWNI--K 249
           L++++   K E  +   EVD + E+ K+   ++ DKD K   LE+ +K QN  + N+  K
Sbjct: 740 LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 799

Query: 250 DELKKVCSTNDLKE 263
           ++++K  S   L+E
Sbjct: 800 EQVEKKKSAQMLEE 813


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score = 37.0 bits (84), Expect = 0.094
 Identities = 23/74 (31%), Positives = 42/74 (56%), Gaps = 5/74 (6%)

Query: 195 LKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSK---LEKALKAQNDLIWNI--K 249
           L++++   K E  +   EVD + E+ K+   ++ DKD K   LE+ +K QN  + N+  K
Sbjct: 712 LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 771

Query: 250 DELKKVCSTNDLKE 263
           ++++K  S   L+E
Sbjct: 772 EQVEKKKSAQMLEE 785


>gi|115527120 nebulin [Homo sapiens]
          Length = 6669

 Score = 37.0 bits (84), Expect = 0.094
 Identities = 34/107 (31%), Positives = 52/107 (48%), Gaps = 9/107 (8%)

Query: 165  KNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKS 224
            K   E+ +R ++      G S+L   D E  KK    + S+ K +    +  D+  K K+
Sbjct: 5753 KQASEVEYRAKHRKEGSHGLSMLGRPDIEMAKKAAK-LSSQVKYR----ENFDK-EKGKT 5806

Query: 225  KKEKDKDSKLEKALKAQNDLIWNI--KDELKKVCS-TNDLKELLIFN 268
             K   KDS+L K +K  N+L   +  K +LKK+     D+KE LI N
Sbjct: 5807 PKYNPKDSQLYKVMKDANNLASEVKYKADLKKLHKPVTDMKESLIMN 5853


>gi|94536838 poly (ADP-ribose) polymerase family, member 6 [Homo
           sapiens]
          Length = 630

 Score = 36.6 bits (83), Expect = 0.12
 Identities = 22/68 (32%), Positives = 34/68 (50%), Gaps = 1/68 (1%)

Query: 847 RYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAP-PEAPVTGYMFGKGIYFADMVSKSA 905
           R++  K+L+     +HGS   N+  IL  GL  A   +  + G  +GKGIY + + S S 
Sbjct: 458 RFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISF 517

Query: 906 NYCHTSQG 913
            Y    +G
Sbjct: 518 GYSGMGKG 525


>gi|24432009 poly (ADP-ribose) polymerase family, member 8 [Homo
           sapiens]
          Length = 854

 Score = 36.2 bits (82), Expect = 0.16
 Identities = 21/61 (34%), Positives = 30/61 (49%), Gaps = 1/61 (1%)

Query: 848 YKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAP-PEAPVTGYMFGKGIYFADMVSKSAN 906
           ++  K+L      +HGS   N+  IL  GL +A      + G M+G GIY + M S S  
Sbjct: 683 FRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFG 742

Query: 907 Y 907
           Y
Sbjct: 743 Y 743


>gi|239757817 PREDICTED: similar to hCG1647425 [Homo sapiens]
          Length = 227

 Score = 35.8 bits (81), Expect = 0.21
 Identities = 39/159 (24%), Positives = 69/159 (43%), Gaps = 20/159 (12%)

Query: 105 KAEKTLGDFAAEYAKSN----RSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWY-- 158
           +A++ LGD A    KS+    +ST +  +   ++ + ++  K  DP  P+   +  +   
Sbjct: 45  RAKQALGDSALLKKKSSTQMLQSTSQSFLRSAQRAETKM--KFEDPNAPKSPPLAFFMFS 102

Query: 159 ---------HPGCFVKN-REELGFRPEYSASQLKG-FSLLATEDKEALKKQLPGVKSEGK 207
                    HPG  + +  ++LG    Y A   K  +   A + KE  +K +     +GK
Sbjct: 103 SEDCPKIKEHPGLSISDVAKKLGEMWNYIAEDDKHPYEKKAVKLKEKYEKDIAAFGGKGK 162

Query: 208 RKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIW 246
               +  G  +  K K KKE+DK   ++    A N L+W
Sbjct: 163 PDAAK-KGAIKAEKCKKKKEEDKMRNMKIKKMATNCLVW 200


>gi|10190716 spindle pole body component 25 [Homo sapiens]
          Length = 224

 Score = 35.4 bits (80), Expect = 0.27
 Identities = 18/70 (25%), Positives = 38/70 (54%), Gaps = 2/70 (2%)

Query: 405 KDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSE--DFLQDV 462
           KD +KA  EKL  KL        + +  + ++ + NK ++E K+  +++++E     Q++
Sbjct: 37  KDSIKAFAEKLSVKLKEEERMVEMFLEYQNQISRQNKLIQEKKDNLLKLIAEVKGKKQEL 96

Query: 463 SASTKSLQEL 472
              T ++Q+L
Sbjct: 97  EVLTANIQDL 106


>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
           b [Homo sapiens]
          Length = 882

 Score = 35.0 bits (79), Expect = 0.36
 Identities = 38/143 (26%), Positives = 66/143 (46%), Gaps = 18/143 (12%)

Query: 129 MEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLA 188
           +E  +K + +L K + + +     M+DR  H     ++RE+   + +      +   LL 
Sbjct: 418 LENSDKEKRQLQKTVAEQDMKMNDMLDRIKH-----QHREQGSIKCKLEEDLQEATKLL- 471

Query: 189 TEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNI 248
            EDK   ++QL   K   K    E++ + +  KKK K  K+   KLE+    +N+   N+
Sbjct: 472 -EDK---REQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEE----ENE---NL 520

Query: 249 KDELKKVCSTNDLKELLIFNKQQ 271
           + EL + CST     L  +N  Q
Sbjct: 521 RAEL-QCCSTQLESSLNKYNTSQ 542


>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
           a [Homo sapiens]
          Length = 1007

 Score = 35.0 bits (79), Expect = 0.36
 Identities = 38/143 (26%), Positives = 66/143 (46%), Gaps = 18/143 (12%)

Query: 129 MEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLA 188
           +E  +K + +L K + + +     M+DR  H     ++RE+   + +      +   LL 
Sbjct: 563 LENSDKEKRQLQKTVAEQDMKMNDMLDRIKH-----QHREQGSIKCKLEEDLQEATKLL- 616

Query: 189 TEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNI 248
            EDK   ++QL   K   K    E++ + +  KKK K  K+   KLE+    +N+   N+
Sbjct: 617 -EDK---REQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEE----ENE---NL 665

Query: 249 KDELKKVCSTNDLKELLIFNKQQ 271
           + EL + CST     L  +N  Q
Sbjct: 666 RAEL-QCCSTQLESSLNKYNTSQ 687


>gi|38788333 remodeling and spacing factor 1 [Homo sapiens]
          Length = 1441

 Score = 34.7 bits (78), Expect = 0.47
 Identities = 24/104 (23%), Positives = 46/104 (44%), Gaps = 6/104 (5%)

Query: 162 CFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAK 221
           C V+NR EL        +Q+    L  +  ++   ++ P ++ E  +K       +E  K
Sbjct: 190 CIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKK------EEETPK 243

Query: 222 KKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELL 265
           ++ +KE +K    E+ +  +N    N+ +E        D KEL+
Sbjct: 244 QEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELV 287



 Score = 30.4 bits (67), Expect = 8.8
 Identities = 42/188 (22%), Positives = 78/188 (41%), Gaps = 22/188 (11%)

Query: 349 KVKKQDRIFPPETSASVAATP---PPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNK 405
           K++K  + F  + +  ++  P   P ST  +    +  A+   P SN+ I    KL+  K
Sbjct: 587 KLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNI-IDHCEKLASEK 645

Query: 406 DEVKAM-IEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSA 464
           + V+      +GG+   +  K  L      E  K + +  +V+  N+       +++ S 
Sbjct: 646 EVVECQSTSTVGGQ---SVKKVDL------ETLKEDSEFTKVEMDNLDNAQTSGIEEPSE 696

Query: 465 STKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKE--------EGI 516
           +  S+Q+    + L P      +E  E+ + R K G  L+ +   + K+        E  
Sbjct: 697 TKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPE 756

Query: 517 NKSEKRMK 524
           NK EK  K
Sbjct: 757 NKQEKTEK 764


>gi|51317384 GLE1 RNA export mediator homolog isoform 1 [Homo
           sapiens]
          Length = 698

 Score = 34.3 bits (77), Expect = 0.61
 Identities = 15/67 (22%), Positives = 32/67 (47%)

Query: 190 EDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIK 249
           + K  LK  L   ++ G +    + G+   + + S    +  ++ E+AL+   DL+ N+ 
Sbjct: 267 QHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLG 326

Query: 250 DELKKVC 256
            E+ + C
Sbjct: 327 QEITRAC 333


>gi|4557627 GLE1 RNA export mediator homolog isoform 2 [Homo
           sapiens]
          Length = 659

 Score = 34.3 bits (77), Expect = 0.61
 Identities = 15/67 (22%), Positives = 32/67 (47%)

Query: 190 EDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIK 249
           + K  LK  L   ++ G +    + G+   + + S    +  ++ E+AL+   DL+ N+ 
Sbjct: 267 QHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLG 326

Query: 250 DELKKVC 256
            E+ + C
Sbjct: 327 QEITRAC 333


>gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens]
          Length = 283

 Score = 33.9 bits (76), Expect = 0.80
 Identities = 34/100 (34%), Positives = 42/100 (42%), Gaps = 8/100 (8%)

Query: 323 VKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNS 382
           V T T    E     + +  SY   L ++K  R  P  T+A    TP P        VNS
Sbjct: 55  VNTDTMTHLE--AQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKVVVNS 112

Query: 383 SASAD-KPLSNMKILTLGKLSRNKD-EVKAMIEKLGGKLT 420
            A+AD +   N   L    LS +K  EVK     LGGK T
Sbjct: 113 PANADYQERFNPSALKDSALSTHKPIEVKG----LGGKAT 148


>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
          Length = 617

 Score = 33.9 bits (76), Expect = 0.80
 Identities = 34/100 (34%), Positives = 42/100 (42%), Gaps = 8/100 (8%)

Query: 323 VKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNS 382
           V T T    E     + +  SY   L ++K  R  P  T+A    TP P        VNS
Sbjct: 55  VNTDTMTHLE--AQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKVVVNS 112

Query: 383 SASAD-KPLSNMKILTLGKLSRNKD-EVKAMIEKLGGKLT 420
            A+AD +   N   L    LS +K  EVK     LGGK T
Sbjct: 113 PANADYQERFNPSALKDSALSTHKPIEVKG----LGGKAT 148


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.131    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,172,448
Number of Sequences: 37866
Number of extensions: 1765705
Number of successful extensions: 7146
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 6908
Number of HSP's gapped (non-prelim): 310
length of query: 1014
length of database: 18,247,518
effective HSP length: 112
effective length of query: 902
effective length of database: 14,006,526
effective search space: 12633886452
effective search space used: 12633886452
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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