BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|156523968 poly (ADP-ribose) polymerase family, member 1 [Homo sapiens] (1014 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|156523968 poly (ADP-ribose) polymerase family, member 1 [Homo... 2028 0.0 gi|110825963 poly (ADP-ribose) polymerase family, member 2 isofo... 386 e-107 gi|110825961 poly (ADP-ribose) polymerase family, member 2 isofo... 386 e-107 gi|158634482 poly (ADP-ribose) polymerase family, member 3 isofo... 244 3e-64 gi|158634478 poly (ADP-ribose) polymerase family, member 3 isofo... 244 3e-64 gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo... 114 4e-25 gi|73747844 ligase III, DNA, ATP-dependent isoform beta precurso... 54 7e-07 gi|73747829 ligase III, DNA, ATP-dependent isoform alpha precurs... 54 7e-07 gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 46 2e-04 gi|194440660 topoisomerase (DNA) II binding protein 1 [Homo sapi... 43 0.001 gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 40 0.009 gi|13124883 HsKin17 protein [Homo sapiens] 39 0.019 gi|32528306 replication factor C large subunit [Homo sapiens] 39 0.032 gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 39 0.032 gi|7657218 bromodomain-containing protein 4 isoform short [Homo ... 38 0.055 gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 38 0.055 gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 37 0.094 gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 37 0.094 gi|115527120 nebulin [Homo sapiens] 37 0.094 gi|94536838 poly (ADP-ribose) polymerase family, member 6 [Homo ... 37 0.12 gi|24432009 poly (ADP-ribose) polymerase family, member 8 [Homo ... 36 0.16 gi|239757817 PREDICTED: similar to hCG1647425 [Homo sapiens] 36 0.21 gi|10190716 spindle pole body component 25 [Homo sapiens] 35 0.27 gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 35 0.36 gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 35 0.36 gi|38788333 remodeling and spacing factor 1 [Homo sapiens] 35 0.47 gi|51317384 GLE1 RNA export mediator homolog isoform 1 [Homo sap... 34 0.61 gi|4557627 GLE1 RNA export mediator homolog isoform 2 [Homo sapi... 34 0.61 gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens] 34 0.80 gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens] 34 0.80 >gi|156523968 poly (ADP-ribose) polymerase family, member 1 [Homo sapiens] Length = 1014 Score = 2028 bits (5254), Expect = 0.0 Identities = 1014/1014 (100%), Positives = 1014/1014 (100%) Query: 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV 60 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV Sbjct: 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV 60 Query: 61 GHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKS 120 GHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKS Sbjct: 61 GHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKS 120 Query: 121 NRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ 180 NRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ Sbjct: 121 NRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ 180 Query: 181 LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKA 240 LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKA Sbjct: 181 LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKA 240 Query: 241 QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSG 300 QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSG Sbjct: 241 QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSG 300 Query: 301 QLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE 360 QLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE Sbjct: 301 QLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE 360 Query: 361 TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT 420 TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT Sbjct: 361 TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT 420 Query: 421 GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSP 480 GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSP Sbjct: 421 GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSP 480 Query: 481 WGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE 540 WGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE Sbjct: 481 WGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE 540 Query: 541 HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNK 600 HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNK Sbjct: 541 HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNK 600 Query: 601 LEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPG 660 LEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPG Sbjct: 601 LEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPG 660 Query: 661 TKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAV 720 TKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAV Sbjct: 661 TKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAV 720 Query: 721 SQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRG 780 SQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRG Sbjct: 721 SQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRG 780 Query: 781 GSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE 840 GSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE Sbjct: 781 GSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE 840 Query: 841 REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM 900 REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM Sbjct: 841 REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM 900 Query: 901 VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSA 960 VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSA Sbjct: 901 VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSA 960 Query: 961 NISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 1014 NISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW Sbjct: 961 NISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 1014 >gi|110825963 poly (ADP-ribose) polymerase family, member 2 isoform 2 [Homo sapiens] Length = 570 Score = 386 bits (991), Expect = e-107 Identities = 216/516 (41%), Positives = 323/516 (62%), Gaps = 17/516 (3%) Query: 512 KEEGINKSEKRMK-LTLKGGAAVDPDSGLE-HSAHVLEKGGKVFSATLGLVDIVKGTNSY 569 K+ +K ++ +K L LKG A VDP+ + AHV +G V+ L ++ N Y Sbjct: 59 KDRTEDKQDESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKY 118 Query: 570 YKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSK 629 Y +QLLEDD + + ++ WGRVG + + + + A E F K + +KT N W + Sbjct: 119 YLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDR 178 Query: 630 N-FTKYPKKFYPLEIDYG---QDEEAVKK---LTVNPGTKSKLPKPVQDLIKMIFDVESM 682 F K P K+ L++DY QDEE KK L +S+L VQ+LIK+I +V++M Sbjct: 179 EKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAM 238 Query: 683 KKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPH 742 ++ M+E + + +K PLGKL+ QI+A Y L +++ + G +++ N FYT IPH Sbjct: 239 EEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPH 298 Query: 743 DFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIK 802 DFG++ PPL+ + K+++L+ L DIE+A L++ S + P+D +Y L ++ Sbjct: 299 DFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQ-SPEHPLDQHYRNLHCALR 357 Query: 803 VVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWH 862 +D +S E ++I +Y+++THA TH+ Y + ++D+F++E++GE + ++ + LHNR LLWH Sbjct: 358 PLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFR--EDLHNRMLLWH 415 Query: 863 GSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLG 922 GSR +N+ GILS GLRIAPPEAP+TGYMFGKGIYFADM SKSANYC S+ GL+LL Sbjct: 416 GSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLS 475 Query: 923 EVALGNMYELKHASHISK-LPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGV-- 979 EVALG EL A+ ++ L +GKHS KGLGK P + ++L+G VPLG +G+ Sbjct: 476 EVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILN 535 Query: 980 -NDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 1014 + +L YNEYIVY+ QV ++YLLK++FNF LW Sbjct: 536 PDGYTLNYNEYIVYNPNQVRMRYLLKVQFNF-LQLW 570 >gi|110825961 poly (ADP-ribose) polymerase family, member 2 isoform 1 [Homo sapiens] Length = 583 Score = 386 bits (991), Expect = e-107 Identities = 215/508 (42%), Positives = 317/508 (62%), Gaps = 16/508 (3%) Query: 519 SEKRMKLTLKGGAAVDPDSGLE-HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLED 577 SE L LKG A VDP+ + AHV +G V+ L ++ N YY +QLLED Sbjct: 80 SESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLED 139 Query: 578 DKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN-FTKYPK 636 D + + ++ WGRVG + + + + A E F K + +KT N W + F K P Sbjct: 140 DAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREKFEKVPG 199 Query: 637 KFYPLEIDYG---QDEEAVKK---LTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYE 690 K+ L++DY QDEE KK L +S+L VQ+LIK+I +V++M++ M+E + Sbjct: 200 KYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEEMMMEMK 259 Query: 691 IDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPP 750 + +K PLGKL+ QI+A Y L +++ + G +++ N FYT IPHDFG++ PP Sbjct: 260 YNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPP 319 Query: 751 LLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEE 810 L+ + K+++L+ L DIE+A L++ S + P+D +Y L ++ +D +S E Sbjct: 320 LIRTQKELSEKIQLLEALGDIEIAIKLVKTELQ-SPEHPLDQHYRNLHCALRPLDHESYE 378 Query: 811 AEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFA 870 ++I +Y+++THA TH+ Y + ++D+F++E++GE + ++ + LHNR LLWHGSR +N+ Sbjct: 379 FKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFR--EDLHNRMLLWHGSRMSNWV 436 Query: 871 GILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMY 930 GILS GLRIAPPEAP+TGYMFGKGIYFADM SKSANYC S+ GL+LL EVALG Sbjct: 437 GILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCN 496 Query: 931 ELKHASHISK-LPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGV---NDTSLLY 986 EL A+ ++ L +GKHS KGLGK P + ++L+G VPLG +G+ + +L Y Sbjct: 497 ELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNY 556 Query: 987 NEYIVYDIAQVNLKYLLKLKFNFKTSLW 1014 NEYIVY+ QV ++YLLK++FNF LW Sbjct: 557 NEYIVYNPNQVRMRYLLKVQFNF-LQLW 583 >gi|158634482 poly (ADP-ribose) polymerase family, member 3 isoform b [Homo sapiens] Length = 533 Score = 244 bits (623), Expect = 3e-64 Identities = 168/476 (35%), Positives = 263/476 (55%), Gaps = 33/476 (6%) Query: 553 FSATLGLVDIVKGTNSYYKLQLLEDDKENRYWI-FRSWGRVGTVIGSNKLEQMPSKEDAI 611 ++ TL +I N +Y +QLL+D NR++ + WGRVG V G +K+ EDA Sbjct: 66 YNCTLNQTNIENNNNKFYIIQLLQDS--NRFFTCWNHWGRVGEV-GQSKINHFTRLEDAK 122 Query: 612 EHFMKLYEEKTGNAWHSKN-FTKYPKKFYPLEIDYGQD-EEAVKKLTVNP-GTKSKLPKP 668 + F K + EKT N W ++ F +P K+ +E+ + +EAV K+ P T +K +P Sbjct: 123 KDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQP 182 Query: 669 ------VQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQ 722 Q LI IF E K M ++D++KMPLGKLSK+QI + L +++A+ Sbjct: 183 CSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKG 242 Query: 723 GSSDSQILD-LSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGG 781 + Q L+ LS+ FYT+IPH+FG +PP +N+ + +QAK +ML L DIE+A +L Sbjct: 243 PTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVS 302 Query: 782 SDDSSKD----PIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIF 837 + + + P+D +Y+ LK ++++D + E ++I+ Y++ T + H L+ I+ Sbjct: 303 EQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQT-GSNHRCPTLQ--HIW 359 Query: 838 KIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYF 897 K+ +EGE R++ +L NR+LLWHG+ A IL+ GLRI P +G GKGIYF Sbjct: 360 KVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPH----SGGRVGKGIYF 415 Query: 898 ADMVSKSANYCHTSQ--GDPIGLILLGEVALGNMYELKHAS-HISKLPKGKHSVKGLGKT 954 A SKSA Y + +G + LGEVALG + + + + P G SV G T Sbjct: 416 ASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHT 475 Query: 955 TPDPS--ANISLDG--VDVPLGTGI-SSGVNDTSLLYNEYIVYDIAQVNLKYLLKL 1005 PDP+ + LDG V VP G + + ++ +EY++Y +Q L+YLL++ Sbjct: 476 EPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEV 531 >gi|158634478 poly (ADP-ribose) polymerase family, member 3 isoform a [Homo sapiens] Length = 540 Score = 244 bits (623), Expect = 3e-64 Identities = 168/476 (35%), Positives = 263/476 (55%), Gaps = 33/476 (6%) Query: 553 FSATLGLVDIVKGTNSYYKLQLLEDDKENRYWI-FRSWGRVGTVIGSNKLEQMPSKEDAI 611 ++ TL +I N +Y +QLL+D NR++ + WGRVG V G +K+ EDA Sbjct: 73 YNCTLNQTNIENNNNKFYIIQLLQDS--NRFFTCWNHWGRVGEV-GQSKINHFTRLEDAK 129 Query: 612 EHFMKLYEEKTGNAWHSKN-FTKYPKKFYPLEIDYGQD-EEAVKKLTVNP-GTKSKLPKP 668 + F K + EKT N W ++ F +P K+ +E+ + +EAV K+ P T +K +P Sbjct: 130 KDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQP 189 Query: 669 ------VQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQ 722 Q LI IF E K M ++D++KMPLGKLSK+QI + L +++A+ Sbjct: 190 CSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKG 249 Query: 723 GSSDSQILD-LSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGG 781 + Q L+ LS+ FYT+IPH+FG +PP +N+ + +QAK +ML L DIE+A +L Sbjct: 250 PTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVS 309 Query: 782 SDDSSKD----PIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIF 837 + + + P+D +Y+ LK ++++D + E ++I+ Y++ T + H L+ I+ Sbjct: 310 EQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQT-GSNHRCPTLQ--HIW 366 Query: 838 KIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYF 897 K+ +EGE R++ +L NR+LLWHG+ A IL+ GLRI P +G GKGIYF Sbjct: 367 KVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPH----SGGRVGKGIYF 422 Query: 898 ADMVSKSANYCHTSQ--GDPIGLILLGEVALGNMYELKHAS-HISKLPKGKHSVKGLGKT 954 A SKSA Y + +G + LGEVALG + + + + P G SV G T Sbjct: 423 ASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHT 482 Query: 955 TPDPS--ANISLDG--VDVPLGTGI-SSGVNDTSLLYNEYIVYDIAQVNLKYLLKL 1005 PDP+ + LDG V VP G + + ++ +EY++Y +Q L+YLL++ Sbjct: 483 EPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEV 538 >gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo sapiens] Length = 1724 Score = 114 bits (286), Expect = 4e-25 Identities = 149/621 (23%), Positives = 257/621 (41%), Gaps = 97/621 (15%) Query: 403 RNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDV 462 + K +++ I++ GGK + + N I ++ +++ ++ + + DF+ Sbjct: 21 QQKKKLQTDIKENGGKFSFSLNPQCTHIILDNADVLSQYQLNSIQKNHVHIANPDFIW-- 78 Query: 463 SASTKSLQELFLAHILS--PWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGI---- 516 KS++E L + + P+ +P+++ P + K S +VK EG+ Sbjct: 79 ----KSIREKRLLDVKNYDPY------KPLDITPPPDQ------KASSSEVKTEGLCPDS 122 Query: 517 -NKSEKRMKLTLKGGAAVD----PDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYK 571 + E ++LT G V+ P + LEK G +V+ Sbjct: 123 ATEEEDTVELTEFGMQNVEIPHLPQDFEVAKYNTLEKVGMEGGQEAVVVE---------- 172 Query: 572 LQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNF 631 LQ D ++ + I + + + + EDA E+F EE + + Sbjct: 173 LQCSRDSRDCPFLISSHFLLDDGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLR-- 230 Query: 632 TKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEI 691 + F P E E+ L S L + V DL++MI+ +A+ E Sbjct: 231 ----EHFTP-EATQLASEQLQALLLEEVMNSSTLSQEVSDLVEMIW-----AEALGHLEH 280 Query: 692 DLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPL 751 L K P+ ++S + A IL V+ A+ G + Q+ + FY LIPH M K Sbjct: 281 MLLK-PVNRISLNDVSKAEGILLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEV- 338 Query: 752 LNNADSVQAKVEMLDNLLD-IEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEE 810 N + K ++ + D + V + L P Y L+ I+ V++++EE Sbjct: 339 --NLGLLAKKADLCQLIRDMVNVCETNL-----SKPNPPSLAKYRALRCKIEHVEQNTEE 391 Query: 811 AEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFA 870 +RK V H H+ ++V+ IF++ R E + +L N R L HGS N Sbjct: 392 FLRVRKEVLQNH---HSKSPVDVLQIFRVGRVNETTEF--LSKLGNVRPLLHGSPVQNIV 446 Query: 871 GILSQGLRIAPPEAPVTGYM------FGKGIYFADMVSKSANYCHTSQGDPIGLILLGEV 924 GIL +GL + P G G GIYF+D +S S Y H + D L+L+ +V Sbjct: 447 GILCRGL-LLPKVVEDRGVQRTDVGNLGSGIYFSDSLSTSIKYSHPGETDGTRLLLICDV 505 Query: 925 ALGNMYELKHAS-HISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTS 983 ALG +L +++ P G SV G+ +T A+++ D D Sbjct: 506 ALGKCMDLHEKDFSLTEAPPGYDSVHGVSQT-----ASVTTDFED--------------- 545 Query: 984 LLYNEYIVYDIAQVNLKYLLK 1004 +E++VY QV +KY++K Sbjct: 546 ---DEFVVYKTNQVKMKYIIK 563 >gi|73747844 ligase III, DNA, ATP-dependent isoform beta precursor [Homo sapiens] Length = 949 Score = 53.9 bits (128), Expect = 7e-07 Identities = 29/111 (26%), Positives = 53/111 (47%), Gaps = 3/111 (2%) Query: 3 ESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFD--GKVPHWYHFSCFWKV 60 E +++ + V+YAK G A CKKC E I K R+ +V +P + G + WYH C ++ Sbjct: 87 EMAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEK 146 Query: 61 GHSIRHPDVEVDGFSELR-WDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTL 110 R +++ +EL W++ + +K + G+ +K + Sbjct: 147 LERARATTKKIEDLTELEGWEELEDNEKEQITQHIADLSSKAAGTPKKKAV 197 Score = 49.7 bits (117), Expect = 1e-05 Identities = 27/95 (28%), Positives = 45/95 (47%), Gaps = 2/95 (2%) Query: 113 FAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVK--NREEL 170 F +YAK + CK C EKI KG R+ K + +P G + WYH C + R Sbjct: 93 FCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARA 152 Query: 171 GFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSE 205 + ++L+G+ L +KE + + + + S+ Sbjct: 153 TTKKIEDLTELEGWEELEDNEKEQITQHIADLSSK 187 >gi|73747829 ligase III, DNA, ATP-dependent isoform alpha precursor [Homo sapiens] Length = 1009 Score = 53.9 bits (128), Expect = 7e-07 Identities = 29/111 (26%), Positives = 53/111 (47%), Gaps = 3/111 (2%) Query: 3 ESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFD--GKVPHWYHFSCFWKV 60 E +++ + V+YAK G A CKKC E I K R+ +V +P + G + WYH C ++ Sbjct: 87 EMAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEK 146 Query: 61 GHSIRHPDVEVDGFSELR-WDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTL 110 R +++ +EL W++ + +K + G+ +K + Sbjct: 147 LERARATTKKIEDLTELEGWEELEDNEKEQITQHIADLSSKAAGTPKKKAV 197 Score = 49.7 bits (117), Expect = 1e-05 Identities = 27/95 (28%), Positives = 45/95 (47%), Gaps = 2/95 (2%) Query: 113 FAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVK--NREEL 170 F +YAK + CK C EKI KG R+ K + +P G + WYH C + R Sbjct: 93 FCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARA 152 Query: 171 GFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSE 205 + ++L+G+ L +KE + + + + S+ Sbjct: 153 TTKKIEDLTELEGWEELEDNEKEQITQHIADLSSK 187 >gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase [Homo sapiens] Length = 1327 Score = 46.2 bits (108), Expect = 2e-04 Identities = 63/237 (26%), Positives = 87/237 (36%), Gaps = 57/237 (24%) Query: 792 VNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDL----EVIDIFKIE----REG 843 VN + D+ D++ + E + H NA + VI I K+ RE Sbjct: 1102 VNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRER 1161 Query: 844 ECQRYKPFKQL----HNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFAD 899 C R K + HN R+L+HGS N I+ +G G MFG GIYFA+ Sbjct: 1162 FCHRQKEVSEENHNHHNERMLFHGSPFIN--AIIHKGF---DERHAYIGGMFGAGIYFAE 1216 Query: 900 MVSKSANY---------CHTSQGDPIGL----ILLGEVALGNMYELKHASHISKLPKGKH 946 SKS Y C T + + +L V LG + ++ P G H Sbjct: 1217 NSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHH 1276 Query: 947 SVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLL 1003 SV G PS N L Y EY++Y Q +YL+ Sbjct: 1277 SVIG------RPSVN---------------------GLAYAEYVIYRGEQAYPEYLI 1306 >gi|194440660 topoisomerase (DNA) II binding protein 1 [Homo sapiens] Length = 1522 Score = 43.1 bits (100), Expect = 0.001 Identities = 61/302 (20%), Positives = 116/302 (38%), Gaps = 26/302 (8%) Query: 193 EALKK-QLPGVKS----EGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWN 247 EA KK LP V E R G D + + +K+E+ ++++ + +D + Sbjct: 706 EAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEH 765 Query: 248 ----IKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCE-----EC 298 ++ K V + D+ F + + S +VA G L E + Sbjct: 766 PGTRLQTHRKTVVTPLDMNR---FQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDT 822 Query: 299 SGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFP 358 + + K + + DV + +TP R + ++ + + L ++ VK Sbjct: 823 PSKFLSKDKLFKPSFDVK---DALAALETPGRP---SQQKRKPSTPLSEVIVKNLQLALA 876 Query: 359 PETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGK 418 + +VA + P A + A KPL + + KLS+ + E+ + LG Sbjct: 877 NSSRNAVALSASPQLKEAQS---EKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGAD 933 Query: 419 LTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHIL 478 + ++ + N++ + VKE + +VSE +L D + K L E H Sbjct: 934 YRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTY 993 Query: 479 SP 480 +P Sbjct: 994 NP 995 >gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 [Homo sapiens] Length = 1166 Score = 40.4 bits (93), Expect = 0.009 Identities = 35/108 (32%), Positives = 46/108 (42%), Gaps = 18/108 (16%) Query: 856 NRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCH---TSQ 912 N R+L+HGS N I+ +G G MFG GIYFA+ SKS Y + Sbjct: 1025 NERMLFHGSPFVN--AIIHKGF---DERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGT 1079 Query: 913 GDPI----------GLILLGEVALGNMYELKHASHISKLPKGKHSVKG 950 G P+ +L V LG + A ++ P G HSV G Sbjct: 1080 GCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTG 1127 >gi|13124883 HsKin17 protein [Homo sapiens] Length = 393 Score = 39.3 bits (90), Expect = 0.019 Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 6/113 (5%) Query: 59 KVGHSIRHPDVEVDGFSEL-RWDDQQKV-----KKTAEAGGVTGKGQDGIGSKAEKTLGD 112 +V + + EV F+EL R +D++KV K + G T +G A KT+G Sbjct: 176 QVRRGLEGKEQEVPTFTELSRENDEEKVTFNLSKGACSSSGATSSKSSTLGPSALKTIGS 235 Query: 113 FAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVK 165 A+ K + + EK +K ++ EK + D W P VK Sbjct: 236 SASVKRKESSQSSTQSKEKKKKKSALDEIMEIEEEKKRTARTDYWLQPEIIVK 288 >gi|32528306 replication factor C large subunit [Homo sapiens] Length = 1147 Score = 38.5 bits (88), Expect = 0.032 Identities = 53/241 (21%), Positives = 97/241 (40%), Gaps = 29/241 (12%) Query: 313 GDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKK---LKVKKQDRIFPPETSASVA--- 366 G+V++ K K RKE + KE ++ +K +K+K + + P +T +S A Sbjct: 308 GEVSS-PKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKT-PKKTKSSPAKKE 365 Query: 367 -ATPPPS--------------TASAPAAVNSSA---SADKPLSNMKILTLGKL-SRNKDE 407 +P S P A+ S A+ L + + G L S +DE Sbjct: 366 SVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDE 425 Query: 408 VKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTK 467 K++IE+ GGK+TG +K + + + + K ++ +++ ED L ++ + Sbjct: 426 AKSLIERYGGKVTGNVSKKTNYLVMGR--DSGQSKSDKAAALGTKIIDEDGLLNLIRTMP 483 Query: 468 SLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTL 527 + + + + E K E +GK + SKK K +K + K Sbjct: 484 GKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIK 543 Query: 528 K 528 K Sbjct: 544 K 544 >gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo sapiens] Length = 956 Score = 38.5 bits (88), Expect = 0.032 Identities = 29/91 (31%), Positives = 43/91 (47%), Gaps = 3/91 (3%) Query: 146 PEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSE 205 P L I + + G KN+ L E QLK E+KE LK++ K E Sbjct: 313 PTSTPLRRITKKFVKGSTEKNKLRLQRDQERLGKQLK--LRAEREEKEKLKEEAKRAKEE 370 Query: 206 GKRKGDEVDGVDEVAKKKSKKEKDKDSKLEK 236 K+K +E + E +++ K+EKD+ K EK Sbjct: 371 AKKKKEEEKELKE-KERREKREKDEKEKAEK 400 >gi|7657218 bromodomain-containing protein 4 isoform short [Homo sapiens] Length = 722 Score = 37.7 bits (86), Expect = 0.055 Identities = 32/126 (25%), Positives = 58/126 (46%), Gaps = 13/126 (10%) Query: 336 PKEFREISYLKKLK-------VKKQDRIFPPETSASVAATPPPSTASAP-----AAVNSS 383 P + ++ +KL+ K D P + S A PPP+ AP ++ +SS Sbjct: 434 PPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSS 493 Query: 384 ASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEK-MNKK 442 + +D + + +L+ ++++KA+ E+L NK KKE +K +K+ Sbjct: 494 SDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKR 553 Query: 443 MEEVKE 448 EEV+E Sbjct: 554 KEEVEE 559 >gi|19718731 bromodomain-containing protein 4 isoform long [Homo sapiens] Length = 1362 Score = 37.7 bits (86), Expect = 0.055 Identities = 32/126 (25%), Positives = 58/126 (46%), Gaps = 13/126 (10%) Query: 336 PKEFREISYLKKLK-------VKKQDRIFPPETSASVAATPPPSTASAP-----AAVNSS 383 P + ++ +KL+ K D P + S A PPP+ AP ++ +SS Sbjct: 434 PPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSS 493 Query: 384 ASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEK-MNKK 442 + +D + + +L+ ++++KA+ E+L NK KKE +K +K+ Sbjct: 494 SDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKR 553 Query: 443 MEEVKE 448 EEV+E Sbjct: 554 KEEVEE 559 >gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens] Length = 1116 Score = 37.0 bits (84), Expect = 0.094 Identities = 23/74 (31%), Positives = 42/74 (56%), Gaps = 5/74 (6%) Query: 195 LKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSK---LEKALKAQNDLIWNI--K 249 L++++ K E + EVD + E+ K+ ++ DKD K LE+ +K QN + N+ K Sbjct: 740 LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 799 Query: 250 DELKKVCSTNDLKE 263 ++++K S L+E Sbjct: 800 EQVEKKKSAQMLEE 813 >gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] Length = 1088 Score = 37.0 bits (84), Expect = 0.094 Identities = 23/74 (31%), Positives = 42/74 (56%), Gaps = 5/74 (6%) Query: 195 LKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSK---LEKALKAQNDLIWNI--K 249 L++++ K E + EVD + E+ K+ ++ DKD K LE+ +K QN + N+ K Sbjct: 712 LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 771 Query: 250 DELKKVCSTNDLKE 263 ++++K S L+E Sbjct: 772 EQVEKKKSAQMLEE 785 >gi|115527120 nebulin [Homo sapiens] Length = 6669 Score = 37.0 bits (84), Expect = 0.094 Identities = 34/107 (31%), Positives = 52/107 (48%), Gaps = 9/107 (8%) Query: 165 KNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKS 224 K E+ +R ++ G S+L D E KK + S+ K + + D+ K K+ Sbjct: 5753 KQASEVEYRAKHRKEGSHGLSMLGRPDIEMAKKAAK-LSSQVKYR----ENFDK-EKGKT 5806 Query: 225 KKEKDKDSKLEKALKAQNDLIWNI--KDELKKVCS-TNDLKELLIFN 268 K KDS+L K +K N+L + K +LKK+ D+KE LI N Sbjct: 5807 PKYNPKDSQLYKVMKDANNLASEVKYKADLKKLHKPVTDMKESLIMN 5853 >gi|94536838 poly (ADP-ribose) polymerase family, member 6 [Homo sapiens] Length = 630 Score = 36.6 bits (83), Expect = 0.12 Identities = 22/68 (32%), Positives = 34/68 (50%), Gaps = 1/68 (1%) Query: 847 RYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAP-PEAPVTGYMFGKGIYFADMVSKSA 905 R++ K+L+ +HGS N+ IL GL A + + G +GKGIY + + S S Sbjct: 458 RFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISF 517 Query: 906 NYCHTSQG 913 Y +G Sbjct: 518 GYSGMGKG 525 >gi|24432009 poly (ADP-ribose) polymerase family, member 8 [Homo sapiens] Length = 854 Score = 36.2 bits (82), Expect = 0.16 Identities = 21/61 (34%), Positives = 30/61 (49%), Gaps = 1/61 (1%) Query: 848 YKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAP-PEAPVTGYMFGKGIYFADMVSKSAN 906 ++ K+L +HGS N+ IL GL +A + G M+G GIY + M S S Sbjct: 683 FRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFG 742 Query: 907 Y 907 Y Sbjct: 743 Y 743 >gi|239757817 PREDICTED: similar to hCG1647425 [Homo sapiens] Length = 227 Score = 35.8 bits (81), Expect = 0.21 Identities = 39/159 (24%), Positives = 69/159 (43%), Gaps = 20/159 (12%) Query: 105 KAEKTLGDFAAEYAKSN----RSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWY-- 158 +A++ LGD A KS+ +ST + + ++ + ++ K DP P+ + + Sbjct: 45 RAKQALGDSALLKKKSSTQMLQSTSQSFLRSAQRAETKM--KFEDPNAPKSPPLAFFMFS 102 Query: 159 ---------HPGCFVKN-REELGFRPEYSASQLKG-FSLLATEDKEALKKQLPGVKSEGK 207 HPG + + ++LG Y A K + A + KE +K + +GK Sbjct: 103 SEDCPKIKEHPGLSISDVAKKLGEMWNYIAEDDKHPYEKKAVKLKEKYEKDIAAFGGKGK 162 Query: 208 RKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIW 246 + G + K K KKE+DK ++ A N L+W Sbjct: 163 PDAAK-KGAIKAEKCKKKKEEDKMRNMKIKKMATNCLVW 200 >gi|10190716 spindle pole body component 25 [Homo sapiens] Length = 224 Score = 35.4 bits (80), Expect = 0.27 Identities = 18/70 (25%), Positives = 38/70 (54%), Gaps = 2/70 (2%) Query: 405 KDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSE--DFLQDV 462 KD +KA EKL KL + + + ++ + NK ++E K+ +++++E Q++ Sbjct: 37 KDSIKAFAEKLSVKLKEEERMVEMFLEYQNQISRQNKLIQEKKDNLLKLIAEVKGKKQEL 96 Query: 463 SASTKSLQEL 472 T ++Q+L Sbjct: 97 EVLTANIQDL 106 >gi|237858621 polyamine modulated factor 1 binding protein 1 isoform b [Homo sapiens] Length = 882 Score = 35.0 bits (79), Expect = 0.36 Identities = 38/143 (26%), Positives = 66/143 (46%), Gaps = 18/143 (12%) Query: 129 MEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLA 188 +E +K + +L K + + + M+DR H ++RE+ + + + LL Sbjct: 418 LENSDKEKRQLQKTVAEQDMKMNDMLDRIKH-----QHREQGSIKCKLEEDLQEATKLL- 471 Query: 189 TEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNI 248 EDK ++QL K K E++ + + KKK K K+ KLE+ +N+ N+ Sbjct: 472 -EDK---REQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEE----ENE---NL 520 Query: 249 KDELKKVCSTNDLKELLIFNKQQ 271 + EL + CST L +N Q Sbjct: 521 RAEL-QCCSTQLESSLNKYNTSQ 542 >gi|237858619 polyamine modulated factor 1 binding protein 1 isoform a [Homo sapiens] Length = 1007 Score = 35.0 bits (79), Expect = 0.36 Identities = 38/143 (26%), Positives = 66/143 (46%), Gaps = 18/143 (12%) Query: 129 MEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLA 188 +E +K + +L K + + + M+DR H ++RE+ + + + LL Sbjct: 563 LENSDKEKRQLQKTVAEQDMKMNDMLDRIKH-----QHREQGSIKCKLEEDLQEATKLL- 616 Query: 189 TEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNI 248 EDK ++QL K K E++ + + KKK K K+ KLE+ +N+ N+ Sbjct: 617 -EDK---REQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEE----ENE---NL 665 Query: 249 KDELKKVCSTNDLKELLIFNKQQ 271 + EL + CST L +N Q Sbjct: 666 RAEL-QCCSTQLESSLNKYNTSQ 687 >gi|38788333 remodeling and spacing factor 1 [Homo sapiens] Length = 1441 Score = 34.7 bits (78), Expect = 0.47 Identities = 24/104 (23%), Positives = 46/104 (44%), Gaps = 6/104 (5%) Query: 162 CFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAK 221 C V+NR EL +Q+ L + ++ ++ P ++ E +K +E K Sbjct: 190 CIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKK------EEETPK 243 Query: 222 KKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELL 265 ++ +KE +K E+ + +N N+ +E D KEL+ Sbjct: 244 QEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELV 287 Score = 30.4 bits (67), Expect = 8.8 Identities = 42/188 (22%), Positives = 78/188 (41%), Gaps = 22/188 (11%) Query: 349 KVKKQDRIFPPETSASVAATP---PPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNK 405 K++K + F + + ++ P P ST + + A+ P SN+ I KL+ K Sbjct: 587 KLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNI-IDHCEKLASEK 645 Query: 406 DEVKAM-IEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSA 464 + V+ +GG+ + K L E K + + +V+ N+ +++ S Sbjct: 646 EVVECQSTSTVGGQ---SVKKVDL------ETLKEDSEFTKVEMDNLDNAQTSGIEEPSE 696 Query: 465 STKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKE--------EGI 516 + S+Q+ + L P +E E+ + R K G L+ + + K+ E Sbjct: 697 TKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPE 756 Query: 517 NKSEKRMK 524 NK EK K Sbjct: 757 NKQEKTEK 764 >gi|51317384 GLE1 RNA export mediator homolog isoform 1 [Homo sapiens] Length = 698 Score = 34.3 bits (77), Expect = 0.61 Identities = 15/67 (22%), Positives = 32/67 (47%) Query: 190 EDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIK 249 + K LK L ++ G + + G+ + + S + ++ E+AL+ DL+ N+ Sbjct: 267 QHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLG 326 Query: 250 DELKKVC 256 E+ + C Sbjct: 327 QEITRAC 333 >gi|4557627 GLE1 RNA export mediator homolog isoform 2 [Homo sapiens] Length = 659 Score = 34.3 bits (77), Expect = 0.61 Identities = 15/67 (22%), Positives = 32/67 (47%) Query: 190 EDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIK 249 + K LK L ++ G + + G+ + + S + ++ E+AL+ DL+ N+ Sbjct: 267 QHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLG 326 Query: 250 DELKKVC 256 E+ + C Sbjct: 327 QEITRAC 333 >gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens] Length = 283 Score = 33.9 bits (76), Expect = 0.80 Identities = 34/100 (34%), Positives = 42/100 (42%), Gaps = 8/100 (8%) Query: 323 VKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNS 382 V T T E + + SY L ++K R P T+A TP P VNS Sbjct: 55 VNTDTMTHLE--AQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKVVVNS 112 Query: 383 SASAD-KPLSNMKILTLGKLSRNKD-EVKAMIEKLGGKLT 420 A+AD + N L LS +K EVK LGGK T Sbjct: 113 PANADYQERFNPSALKDSALSTHKPIEVKG----LGGKAT 148 >gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens] Length = 617 Score = 33.9 bits (76), Expect = 0.80 Identities = 34/100 (34%), Positives = 42/100 (42%), Gaps = 8/100 (8%) Query: 323 VKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNS 382 V T T E + + SY L ++K R P T+A TP P VNS Sbjct: 55 VNTDTMTHLE--AQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKVVVNS 112 Query: 383 SASAD-KPLSNMKILTLGKLSRNKD-EVKAMIEKLGGKLT 420 A+AD + N L LS +K EVK LGGK T Sbjct: 113 PANADYQERFNPSALKDSALSTHKPIEVKG----LGGKAT 148 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.131 0.377 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 38,172,448 Number of Sequences: 37866 Number of extensions: 1765705 Number of successful extensions: 7146 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 18 Number of HSP's successfully gapped in prelim test: 106 Number of HSP's that attempted gapping in prelim test: 6908 Number of HSP's gapped (non-prelim): 310 length of query: 1014 length of database: 18,247,518 effective HSP length: 112 effective length of query: 902 effective length of database: 14,006,526 effective search space: 12633886452 effective search space used: 12633886452 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.