Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 156071474

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|156071474 solute carrier family 4, anion exchanger, member 2
(erythrocyte membrane protein band 3-like 1) [Homo sapiens]
         (1241 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|156071474 solute carrier family 4, anion exchanger, member 2 ...  2462   0.0  
gi|157671951 solute carrier family 4, anion exchanger, member 3 ...  1359   0.0  
gi|157671953 solute carrier family 4, anion exchanger, member 3 ...  1355   0.0  
gi|4507021 solute carrier family 4, anion exchanger, member 1 [H...  1011   0.0  
gi|90403614 solute carrier family 4, sodium bicarbonate cotransp...   679   0.0  
gi|90568034 solute carrier family 4, sodium bicarbonate cotransp...   679   0.0  
gi|155722998 solute carrier family 4, sodium bicarbonate transpo...   673   0.0  
gi|197927160 solute carrier family 4, sodium bicarbonate cotrans...   658   0.0  
gi|4507025 solute carrier family 4, sodium bicarbonate cotranspo...   658   0.0  
gi|148596928 solute carrier family 4, sodium bicarbonate cotrans...   658   0.0  
gi|19743827 sodium bicarbonate transporter 4 isoform c [Homo sap...   603   e-172
gi|125987596 sodium bicarbonate transporter 4 isoform a [Homo sa...   593   e-169
gi|151101449 solute carrier family 4, sodium bicarbonate cotrans...   577   e-164
gi|134288865 solute carrier family 4, sodium bicarbonate cotrans...   568   e-161
gi|14042960 solute carrier family 4 member 11 [Homo sapiens]          251   4e-66
gi|61742808 hypothetical protein LOC283638 isoform 2 [Homo sapiens]    46   3e-04
gi|163644261 hypothetical protein LOC283638 isoform 1 [Homo sapi...    46   3e-04
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         45   3e-04
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    45   6e-04
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]      44   0.001
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]      44   0.001
gi|195963316 PWWP domain containing 2A isoform b [Homo sapiens]        43   0.002
gi|153791982 PWWP domain containing 2A isoform a [Homo sapiens]        43   0.002
gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]                  42   0.004
gi|166795264 AE binding protein 2 isoform b [Homo sapiens]             42   0.004
gi|166795262 AE binding protein 2 isoform a [Homo sapiens]             42   0.004
gi|59806361 hypothetical protein LOC387104 [Homo sapiens]              41   0.006
gi|91208420 bassoon protein [Homo sapiens]                             41   0.006
gi|4502805 chromogranin A precursor [Homo sapiens]                     41   0.008
gi|239754674 PREDICTED: hypothetical protein [Homo sapiens]            41   0.008

>gi|156071474 solute carrier family 4, anion exchanger, member 2
            (erythrocyte membrane protein band 3-like 1) [Homo
            sapiens]
          Length = 1241

 Score = 2462 bits (6380), Expect = 0.0
 Identities = 1241/1241 (100%), Positives = 1241/1241 (100%)

Query: 1    MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE 60
            MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE
Sbjct: 1    MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE 60

Query: 61   EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT 120
            EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT
Sbjct: 61   EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT 120

Query: 121  IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ 180
            IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ
Sbjct: 121  IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ 180

Query: 181  EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR 240
            EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR
Sbjct: 181  EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR 240

Query: 241  IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG 300
            IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG
Sbjct: 241  IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG 300

Query: 301  REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW 360
            REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW
Sbjct: 301  REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW 360

Query: 361  GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL 420
            GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL
Sbjct: 361  GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL 420

Query: 421  RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV 480
            RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV
Sbjct: 421  RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV 480

Query: 481  ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA 540
            ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA
Sbjct: 481  ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA 540

Query: 541  VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT 600
            VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT
Sbjct: 541  VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT 600

Query: 601  AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL 660
            AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL
Sbjct: 601  AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL 660

Query: 661  LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL 720
            LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL
Sbjct: 661  LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL 720

Query: 721  SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS 780
            SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS
Sbjct: 721  SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS 780

Query: 781  FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF 840
            FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF
Sbjct: 781  FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF 840

Query: 841  YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT 900
            YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT
Sbjct: 841  YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT 900

Query: 901  ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ 960
            ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ
Sbjct: 901  ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ 960

Query: 961  KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS 1020
            KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS
Sbjct: 961  KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS 1020

Query: 1021 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK 1080
            KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK
Sbjct: 1021 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK 1080

Query: 1081 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH 1140
            PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH
Sbjct: 1081 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH 1140

Query: 1141 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR 1200
            LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR
Sbjct: 1141 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR 1200

Query: 1201 MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1241
            MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV
Sbjct: 1201 MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1241


>gi|157671951 solute carrier family 4, anion exchanger, member 3
            isoform 1 [Homo sapiens]
          Length = 1232

 Score = 1359 bits (3517), Expect = 0.0
 Identities = 738/1239 (59%), Positives = 891/1239 (71%), Gaps = 67/1239 (5%)

Query: 32   EQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPP 91
            E+E+D+L +TL V RF +++ +  +   E+P RSY E DFE+HR +SHH HHPLS  LPP
Sbjct: 32   EEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPP 91

Query: 92   DARRRKTPQGPGRKPRRR-----PGASPTGETPTIEEG-------EEDEDEASEAEGARA 139
              + R+ P    R  RR+       A P+  TP I+E        EE+E+E  E E    
Sbjct: 92   PHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAE 151

Query: 140  LTQPSPVSTPSSVQFFLQED-DSADRKAERTSPSSPAPL--PHQEATPRASKGAQAGTQV 196
              +P P  TP   +F +  D D +     R + + P P   PH + +P+ S  + +    
Sbjct: 152  PVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPS---- 207

Query: 197  EEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVP 256
              A A  +A           G   RP   +     SY+L+ER   GS  G       +VP
Sbjct: 208  PRARASRLA-----------GEKSRPWSPSA----SYDLRERLCPGSALGNPGGPEQQVP 252

Query: 257  TDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTP-----R 311
            TDE EAQ L +ADLD MKSHR ED PGVRRHLV+K ++  TQ GR G   G  P     +
Sbjct: 253  TDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGLAPILRRKK 309

Query: 312  ARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFR 371
             + +   +PHEVFVELNEL+LD++QEP WRETARWIKFEEDVEEETERWGKPHVASLSFR
Sbjct: 310  KKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFR 369

Query: 372  SLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPS 431
            SLLELRRT+AHGA LLDL+Q TLPG+AH VVE M++SDQI+ EDRA+VLR LLLKHSHP+
Sbjct: 370  SLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPN 429

Query: 432  DEKDFSF-PRNISAGSLGSLLGHHHGQGAESDPHVTEPLMG---GVPETRLEVERERELP 487
            D+KD  F PRN S+ S+ S+LG+HH   +   P    P M    G P      + + +  
Sbjct: 430  DDKDSGFFPRNPSSSSMNSVLGNHHPTPSHG-PDGAVPTMADDLGEPAPLWPHDPDAKEK 488

Query: 488  PPAPPAGIT-RSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAV 546
            P   P G   R KS   LKLLEKIPE+AEATVVLVGCV FL +P  AFVRL EAV L++V
Sbjct: 489  PLHMPGGDGHRGKS---LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESV 545

Query: 547  LEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFL 606
            LEVPVPVRFLF++LGPS  + DYHE+GRSI+TLMSDK FHEAAY AD+R+DLL+AI+ FL
Sbjct: 546  LEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFL 605

Query: 607  DCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL-LQMVE 665
            D S+V+PPSEV+G +LLRSVA FQR++L+KR E+ +           +A  K L L++  
Sbjct: 606  DGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGG 665

Query: 666  AAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAIT 725
            +    EDDPL RTG  FGGL+RDVRRRYPHY SD RDAL  QC+AAV+FIYFAALSPAIT
Sbjct: 666  SEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAIT 725

Query: 726  FGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSN 785
            FGGLLGEKT+ L+GVSELI+STA+ GV+F LLGAQPLLV+GFSGPLLVFEEAFF FC + 
Sbjct: 726  FGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQ 785

Query: 786  HLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVK 845
             LEYL GRVW+G WLV   L +VA EGSFLVR++S FTQEIFAFLISLIFIYETFYKL K
Sbjct: 786  DLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYK 845

Query: 846  IFQEHPL---HGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTAL 902
            +F EHPL   +    +    +D G     +   PT GP +           PR QPNTAL
Sbjct: 846  VFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPS-----------PRNQPNTAL 894

Query: 903  LSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKL 962
            LSL+LM GTFFIAFFLRKF+NSRF  G+ RR+IGDFG+PI+IL+MVLVDYSI DTYTQKL
Sbjct: 895  LSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKL 954

Query: 963  SVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKK 1022
            +VP+G SVT+P+KR W I PLG   PFP WMMVA+ +PA+LV ILIFMETQIT LI+S+K
Sbjct: 955  TVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQK 1014

Query: 1023 ERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPK 1082
             R L KGSGFHLDLLLI ++GG+C LFGLPWL AATVRSVTH NALTVM  A+APGDKP+
Sbjct: 1015 ARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQ 1074

Query: 1083 IQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLL 1142
            IQEV+EQRVTG+L+A LVGLSIV+G +LR+IPLAVLFGIFLYMGVTSL+GIQ  +RL L+
Sbjct: 1075 IQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLI 1134

Query: 1143 LMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMV 1202
            LMP KHHP+  YV KV+T RMHLFT +QL C+ALLW V STAASLAFPF+L+LTVPLR  
Sbjct: 1135 LMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHC 1194

Query: 1203 VLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1241
            +L R+F DRE++ LD+ +AEP FDE +G DEYNE+ MPV
Sbjct: 1195 LLPRLFQDRELQALDSEDAEPNFDE-DGQDEYNELHMPV 1232


>gi|157671953 solute carrier family 4, anion exchanger, member 3
            isoform 2 [Homo sapiens]
          Length = 1259

 Score = 1355 bits (3508), Expect = 0.0
 Identities = 738/1247 (59%), Positives = 894/1247 (71%), Gaps = 56/1247 (4%)

Query: 32   EQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPP 91
            E+E+D+L +TL V RF +++ +  +   E+P RSY E DFE+HR +SHH HHPLS  LPP
Sbjct: 32   EEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPP 91

Query: 92   DARRRKTPQGPGRKPRRR-----PGASPTGETPTIEEG-------EEDEDEASEAEGARA 139
              + R+ P    R  RR+       A P+  TP I+E        EE+E+E  E E    
Sbjct: 92   PHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAE 151

Query: 140  LTQPSPVSTPSSVQFFLQED-DSADRKAERTSPSSPAPL--PHQEATPRASKGAQA---- 192
              +P P  TP   +F +  D D +     R + + P P   PH + +P+ S    +    
Sbjct: 152  PVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRD 211

Query: 193  --GTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGH--RSYNLQERRRIGSMTGAE 248
              GT      +  +     ++      AS     K++P     SY+L+ER   GS  G  
Sbjct: 212  GDGTTDLALSSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNP 271

Query: 249  QALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGP 308
                 +VPTDE EAQ L +ADLD MKSHR ED PGVRRHLV+K ++  TQ GR G   G 
Sbjct: 272  GGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGL 328

Query: 309  TP-----RARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKP 363
             P     + + +   +PHEVFVELNEL+LD++QEP WRETARWIKFEEDVEEETERWGKP
Sbjct: 329  APILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKP 388

Query: 364  HVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRAL 423
            HVASLSFRSLLELRRT+AHGA LLDL+Q TLPG+AH VVE M++SDQI+ EDRA+VLR L
Sbjct: 389  HVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTL 448

Query: 424  LLKHSHPSDEKDFSF-PRNISAGSLGSLLGHHHGQGAESDPHVTEPLMG---GVPETRLE 479
            LLKHSHP+D+KD  F PRN S+ S+ S+LG+HH   +   P    P M    G P     
Sbjct: 449  LLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHG-PDGAVPTMADDLGEPAPLWP 507

Query: 480  VERERELPPPAPPAGIT-RSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLR 538
             + + +  P   P G   R KS   LKLLEKIPE+AEATVVLVGCV FL +P  AFVRL 
Sbjct: 508  HDPDAKEKPLHMPGGDGHRGKS---LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLN 564

Query: 539  EAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDL 598
            EAV L++VLEVPVPVRFLF++LGPS  + DYHE+GRSI+TLMSDK FHEAAY AD+R+DL
Sbjct: 565  EAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDL 624

Query: 599  LTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDK 658
            L+AI+ FLD S+V+PPSEV+G +LLRSVA FQR++L+KR E+ +           +A  K
Sbjct: 625  LSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGK 684

Query: 659  AL-LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYF 717
             L L++  +    EDDPL RTG  FGGL+RDVRRRYPHY SD RDAL  QC+AAV+FIYF
Sbjct: 685  ELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYF 744

Query: 718  AALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEA 777
            AALSPAITFGGLLGEKT+ L+GVSELI+STA+ GV+F LLGAQPLLV+GFSGPLLVFEEA
Sbjct: 745  AALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEA 804

Query: 778  FFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIY 837
            FF FC +  LEYL GRVW+G WLV   L +VA EGSFLVR++S FTQEIFAFLISLIFIY
Sbjct: 805  FFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIY 864

Query: 838  ETFYKLVKIFQEHPL---HGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKP 894
            ETFYKL K+F EHPL   +    +    +D G     +   PT GP +           P
Sbjct: 865  ETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPS-----------P 913

Query: 895  RGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSI 954
            R QPNTALLSL+LM GTFFIAFFLRKF+NSRF  G+ RR+IGDFG+PI+IL+MVLVDYSI
Sbjct: 914  RNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSI 973

Query: 955  EDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQI 1014
             DTYTQKL+VP+G SVT+P+KR W I PLG   PFP WMMVA+ +PA+LV ILIFMETQI
Sbjct: 974  TDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQI 1033

Query: 1015 TTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKA 1074
            T LI+S+K R L KGSGFHLDLLLI ++GG+C LFGLPWL AATVRSVTH NALTVM  A
Sbjct: 1034 TALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTA 1093

Query: 1075 VAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQ 1134
            +APGDKP+IQEV+EQRVTG+L+A LVGLSIV+G +LR+IPLAVLFGIFLYMGVTSL+GIQ
Sbjct: 1094 IAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQ 1153

Query: 1135 FYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILI 1194
              +RL L+LMP KHHP+  YV KV+T RMHLFT +QL C+ALLW V STAASLAFPF+L+
Sbjct: 1154 LSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLL 1213

Query: 1195 LTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1241
            LTVPLR  +L R+F DRE++ LD+ +AEP FDE +G DEYNE+ MPV
Sbjct: 1214 LTVPLRHCLLPRLFQDRELQALDSEDAEPNFDE-DGQDEYNELHMPV 1259


>gi|4507021 solute carrier family 4, anion exchanger, member 1 [Homo
            sapiens]
          Length = 911

 Score = 1011 bits (2613), Expect = 0.0
 Identities = 539/926 (58%), Positives = 682/926 (73%), Gaps = 74/926 (7%)

Query: 321  HEVFVELNELLLD-KNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 379
            H+V+VEL EL++D KNQE +W E ARW++ EE++ E    WG+PH++ L+F SLLELRR 
Sbjct: 55   HKVYVELQELVMDEKNQELRWMEAARWVQLEENLGENGA-WGRPHLSHLTFWSLLELRRV 113

Query: 380  LAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFP 439
               G VLLDL + +L GVA+Q++++ +  DQI+ +DR  +LRALLLKHSH          
Sbjct: 114  FTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSH---------- 163

Query: 440  RNISAGSLGSLLGHHHGQGAES-DPHVTEPLMG--GVPETRLEVERERELPPPAPPAGIT 496
                AG L +L G        S DP  ++PL+      ET+L  E+         P+GI 
Sbjct: 164  ----AGELEALGGVKPAVLTRSGDP--SQPLLPQHSSLETQLFCEQGDGGTEGHSPSGI- 216

Query: 497  RSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFL 556
                      LEKIP ++EAT+VLVG  +FL +P + FVRL+EA EL+AV E+PVP+RFL
Sbjct: 217  ----------LEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAV-ELPVPIRFL 265

Query: 557  FLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSE 616
            F+LLGP + ++DY ++GR+ +TLMS++ F   AY+A  R +LL ++  FLDCS+VLPP++
Sbjct: 266  FVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTD 325

Query: 617  VQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLR 676
               E+ L S+   QR++L++R +     P           D +  + ++  G   DDPL+
Sbjct: 326  APSEQALLSLVPVQRELLRRRYQSSPAKP-----------DSSFYKGLDLNGGP-DDPLQ 373

Query: 677  RTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQD 736
            +TG+ FGGL+RD+RRRYP+YLSD  DA  PQ LAAVIFIYFAALSPAITFGGLLGEKT++
Sbjct: 374  QTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEKTRN 433

Query: 737  LIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWI 796
             +GVSEL++STA+QG++F LLGAQPLLV+GFSGPLLVFEEAFFSFC +N LEY+VGRVWI
Sbjct: 434  QMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWI 493

Query: 797  GFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCS 856
            GFWL+ L +L+VA EGSFLVRF+SR+TQEIF+FLISLIFIYETF KL+KIFQ+HPL    
Sbjct: 494  GFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTY 553

Query: 857  ASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQ-PNTALLSLVLMAGTFFIA 915
              N   V                             KP+G  PNTALLSLVLMAGTFF A
Sbjct: 554  NYNVLMVP----------------------------KPQGPLPNTALLSLVLMAGTFFFA 585

Query: 916  FFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEK 975
              LRKFKNS +FPG++RRVIGDFGVPI+ILIMVLVD+ I+DTYTQKLSVP GF V+    
Sbjct: 586  MMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSA 645

Query: 976  RGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLD 1035
            RGWVI+PLG +S FP+WMM AS LPA+LVFILIF+E+QITTLI+SK ER + KGSGFHLD
Sbjct: 646  RGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLD 705

Query: 1036 LLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLL 1095
            LLL+V MGG+ ALFG+PWL+A TVRSVTHANALTVM KA  PG   +IQEVKEQR++GLL
Sbjct: 706  LLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLL 765

Query: 1096 VALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYV 1155
            VA+LVGLSI++  +L +IPLAVLFGIFLYMGVTSL+GIQ ++R+ LL  PPK+HPDV YV
Sbjct: 766  VAVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYV 825

Query: 1156 KKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKC 1215
            K+V+T RMHLFT +Q++CLA+LW V ST ASLA PF+LILTVPLR V+L  IF + E++C
Sbjct: 826  KRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQC 885

Query: 1216 LDANEAEPVFDEREGVDEYNEMPMPV 1241
            LDA++A+  FDE EG DEY+E+ MPV
Sbjct: 886  LDADDAKATFDEEEGRDEYDEVAMPV 911


>gi|90403614 solute carrier family 4, sodium bicarbonate
            cotransporter, member 8 isoform a [Homo sapiens]
          Length = 1093

 Score =  679 bits (1753), Expect = 0.0
 Identities = 404/1037 (38%), Positives = 587/1037 (56%), Gaps = 90/1037 (8%)

Query: 229  GHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDL---MKSHRFEDVPGVR 285
            G  SY   +   +    G    L      +E+E        + +    +SHR     G +
Sbjct: 11   GVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHG-Q 69

Query: 286  RHLVRKNAKGSTQSGREGREP--GPTPRARPR--------APHKPHEVFVELNELLLDKN 335
            +H  R   KG++Q G EG E     TP  R +          H PHE+F EL+E+ + + 
Sbjct: 70   KHRRRGRGKGASQ-GEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEG 128

Query: 336  QEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLP 395
            ++ +W+ETARW+KFEEDVE+  ERW KP+VA+LS  SL ELR  L +G VLLD+   ++ 
Sbjct: 129  EDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIE 188

Query: 396  GVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSF-PRNISAGSLGSLLGHH 454
             ++  +++Q  +S  +    R  V  ALL KH H +++K  +  P   S   +G      
Sbjct: 189  EISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGK----- 243

Query: 455  HGQGAESDPHVTEP-----LMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEK 509
                 +SDPH+ +          VP T LEV+          P  +    SK +L  ++K
Sbjct: 244  ----KQSDPHLMDKHGQTVSPQSVPTTNLEVKNGVNCEHS--PVDL----SKVDLHFMKK 293

Query: 510  IPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDY 569
            IP  AEA+ VLVG V+ L RP +AFVRL  AV L  + EVP+P RFLF+LLGP      Y
Sbjct: 294  IPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQY 353

Query: 570  HEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHF 629
            HEIGRS++T+M+D+ FH+ AY A ER+DLL  I+ FLD   VLPP E      +    + 
Sbjct: 354  HEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNV 413

Query: 630  QRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDV 689
              Q  +KR+  G  +P G     +           E  G      L+RTGR FGGL+ D+
Sbjct: 414  PSQ--EKRKMPG--VPNGNVCHIEQ----------EPHGGHSGPELQRTGRLFGGLVLDI 459

Query: 690  RRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTAL 749
            +R+ P Y SD+RDAL  QCLA+ +F+Y A +SP ITFGGLLGE T+  I   E +   ++
Sbjct: 460  KRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASM 519

Query: 750  QGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVA 809
             G+ + L   Q L ++G +GP+LVFE+  F FC    L YL  R  IG W  FL +++VA
Sbjct: 520  TGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVA 579

Query: 810  LEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASN---------- 859
             + S LV +++RFT+E FA LI +IFIYE   KL+ + + +P+H  S  +          
Sbjct: 580  TDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCT 639

Query: 860  -------------------SSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT 900
                               ++EV    N+T +  +   G    S  G  G       P+ 
Sbjct: 640  LPENPNNHTLQYWKDHNIVTAEVHWA-NLTVSECQEMHGEFMGSACGHHGP----YTPDV 694

Query: 901  ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ 960
               S +L   TF ++  L+ FK SR+FP R+R ++ DF V + I  MV++D+ I    + 
Sbjct: 695  LFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLI-GVPSP 753

Query: 961  KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS 1020
            KL VPS F  T  + RGW+INP+G   P P W ++A+++PA+L  ILIFM+ QIT +II+
Sbjct: 754  KLQVPSVFKPTR-DDRGWIINPIG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIIN 809

Query: 1021 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK 1080
            +KE  L+KG G+HLDLL++  M G+C++ GLPW  AATV S+TH N+L + S+  APG++
Sbjct: 810  RKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQ 869

Query: 1081 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH 1140
            PK   ++EQRVTGL++ +L+G S+ +  +L+ IP+ VL+G+FLYMGV+SL GIQF++RL 
Sbjct: 870  PKFLGIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLK 929

Query: 1141 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR 1200
            L  MP KH PD  Y++ V   ++HLFT +QL CL LLW + ++ A++ FP +++  V +R
Sbjct: 930  LFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVR 989

Query: 1201 MVVLTRIFTDREMKCLD 1217
              V+   F+ RE+  LD
Sbjct: 990  K-VMDLCFSKRELSWLD 1005


>gi|90568034 solute carrier family 4, sodium bicarbonate
            cotransporter, member 8 isoform b [Homo sapiens]
          Length = 1044

 Score =  679 bits (1753), Expect = 0.0
 Identities = 404/1037 (38%), Positives = 587/1037 (56%), Gaps = 90/1037 (8%)

Query: 229  GHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDL---MKSHRFEDVPGVR 285
            G  SY   +   +    G    L      +E+E        + +    +SHR     G +
Sbjct: 11   GVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHG-Q 69

Query: 286  RHLVRKNAKGSTQSGREGREP--GPTPRARPR--------APHKPHEVFVELNELLLDKN 335
            +H  R   KG++Q G EG E     TP  R +          H PHE+F EL+E+ + + 
Sbjct: 70   KHRRRGRGKGASQ-GEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEG 128

Query: 336  QEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLP 395
            ++ +W+ETARW+KFEEDVE+  ERW KP+VA+LS  SL ELR  L +G VLLD+   ++ 
Sbjct: 129  EDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIE 188

Query: 396  GVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSF-PRNISAGSLGSLLGHH 454
             ++  +++Q  +S  +    R  V  ALL KH H +++K  +  P   S   +G      
Sbjct: 189  EISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGK----- 243

Query: 455  HGQGAESDPHVTEP-----LMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEK 509
                 +SDPH+ +          VP T LEV+          P  +    SK +L  ++K
Sbjct: 244  ----KQSDPHLMDKHGQTVSPQSVPTTNLEVKNGVNCEHS--PVDL----SKVDLHFMKK 293

Query: 510  IPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDY 569
            IP  AEA+ VLVG V+ L RP +AFVRL  AV L  + EVP+P RFLF+LLGP      Y
Sbjct: 294  IPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQY 353

Query: 570  HEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHF 629
            HEIGRS++T+M+D+ FH+ AY A ER+DLL  I+ FLD   VLPP E      +    + 
Sbjct: 354  HEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNV 413

Query: 630  QRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDV 689
              Q  +KR+  G  +P G     +           E  G      L+RTGR FGGL+ D+
Sbjct: 414  PSQ--EKRKMPG--VPNGNVCHIEQ----------EPHGGHSGPELQRTGRLFGGLVLDI 459

Query: 690  RRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTAL 749
            +R+ P Y SD+RDAL  QCLA+ +F+Y A +SP ITFGGLLGE T+  I   E +   ++
Sbjct: 460  KRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASM 519

Query: 750  QGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVA 809
             G+ + L   Q L ++G +GP+LVFE+  F FC    L YL  R  IG W  FL +++VA
Sbjct: 520  TGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVA 579

Query: 810  LEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASN---------- 859
             + S LV +++RFT+E FA LI +IFIYE   KL+ + + +P+H  S  +          
Sbjct: 580  TDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCT 639

Query: 860  -------------------SSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT 900
                               ++EV    N+T +  +   G    S  G  G       P+ 
Sbjct: 640  LPENPNNHTLQYWKDHNIVTAEVHWA-NLTVSECQEMHGEFMGSACGHHGP----YTPDV 694

Query: 901  ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ 960
               S +L   TF ++  L+ FK SR+FP R+R ++ DF V + I  MV++D+ I    + 
Sbjct: 695  LFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLI-GVPSP 753

Query: 961  KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS 1020
            KL VPS F  T  + RGW+INP+G   P P W ++A+++PA+L  ILIFM+ QIT +II+
Sbjct: 754  KLQVPSVFKPTR-DDRGWIINPIG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIIN 809

Query: 1021 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK 1080
            +KE  L+KG G+HLDLL++  M G+C++ GLPW  AATV S+TH N+L + S+  APG++
Sbjct: 810  RKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQ 869

Query: 1081 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH 1140
            PK   ++EQRVTGL++ +L+G S+ +  +L+ IP+ VL+G+FLYMGV+SL GIQF++RL 
Sbjct: 870  PKFLGIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLK 929

Query: 1141 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR 1200
            L  MP KH PD  Y++ V   ++HLFT +QL CL LLW + ++ A++ FP +++  V +R
Sbjct: 930  LFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVR 989

Query: 1201 MVVLTRIFTDREMKCLD 1217
              V+   F+ RE+  LD
Sbjct: 990  K-VMDLCFSKRELSWLD 1005


>gi|155722998 solute carrier family 4, sodium bicarbonate
            transporter-like, member 10 [Homo sapiens]
          Length = 1088

 Score =  673 bits (1737), Expect = 0.0
 Identities = 390/1003 (38%), Positives = 568/1003 (56%), Gaps = 71/1003 (7%)

Query: 274  KSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGP--TPRARPR---------APHKPHE 322
            KSHR     G   H  RK  +       +GRE     TP  R +           H PH+
Sbjct: 60   KSHRRHRHRG---HKHRKRDRERDSGLEDGRESPSFDTPSQRVQFILGTEDDDEEHIPHD 116

Query: 323  VFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAH 382
            +F EL+E+   + ++ +WRETARW+KFEEDVE+  ERW KP+VA+LS  SL ELR  + +
Sbjct: 117  LFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILN 176

Query: 383  GAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFS-FPRN 441
            G VLLD+   TL  +A  V++Q V S Q+  + R  V  AL+ +H H + +K  +  P  
Sbjct: 177  GTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIV 236

Query: 442  ISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSKSK 501
             S   +G      +     +   V+        E + +V RE            T   SK
Sbjct: 237  RSFADIGKKQSEPNSMDKNAGQVVSPQSAPACVENKNDVSRENS----------TVDFSK 286

Query: 502  HELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLG 561
             +L  ++KIP  AEA+ +LVG +EFL R  +AFVRL  AV L  + EVP+P RFLF+LLG
Sbjct: 287  VDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLG 346

Query: 562  PSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEE 621
            P      YHEIGRSI+TLM+D+ FH+ AY A +R DL++ I+ FLD   VLPP E     
Sbjct: 347  PLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSI 406

Query: 622  LLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRP 681
             +    +   Q  +K       +P G     ++          E  G      L+RTGR 
Sbjct: 407  RIEPPKNVPSQEKRKIPA----VPNGTAAHGEA----------EPHGGHSGPELQRTGRI 452

Query: 682  FGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVS 741
            FGGLI D++R+ P++ SDFRDA   QCLA+ +F+Y A +SP ITFGGLLGE T+  I   
Sbjct: 453  FGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAI 512

Query: 742  ELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLV 801
            E +   ++ G+ + L G QPL ++G +GP+LVFE+  F FC    L YL  R  IG W  
Sbjct: 513  ESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTA 572

Query: 802  FLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPL--------- 852
             L +++VA + S LV +++RFT+E FA LI +IFIYE   KL ++ + +P+         
Sbjct: 573  TLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDLELL 632

Query: 853  --HGCSASNSSEVDGGENMTWAGARPTLG---------PGNRSLAGQ-----SGQGKPRG 896
              + C+         G    W  +  +              +SL G+      G   P  
Sbjct: 633  TQYSCNCVEPHNPSNGTLKEWRESNISASDIIWENLTVSECKSLHGEYVGRACGHDHPY- 691

Query: 897  QPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIED 956
             P+    S++L   T  ++  L++FK SR+FP ++R ++ DF V + IL MVL+DY+I  
Sbjct: 692  VPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAI-G 750

Query: 957  TYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITT 1016
              + KL VPS F  T  + RGW + PLG   P P W ++A+++PA+L  ILIFM+ QIT 
Sbjct: 751  IPSPKLQVPSVFKPTR-DDRGWFVTPLG---PNPWWTVIAAIIPALLCTILIFMDQQITA 806

Query: 1017 LIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVA 1076
            +II++KE  L+KG G+HLDLL++  M G+C++ GLPW  AATV S+TH N+L + S+  A
Sbjct: 807  VIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSA 866

Query: 1077 PGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFY 1136
            PG++PK   ++EQRVTGL++ +L+G S+ +  +L+ IP+ VL+G+FLYMG +SL GIQF+
Sbjct: 867  PGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFF 926

Query: 1137 ERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILT 1196
            +R+ L  MP KH PD  Y++ V   ++HLFT +Q+ CL LLW +  + A++ FP +++  
Sbjct: 927  DRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSRAAIVFPMMVLAL 986

Query: 1197 VPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPM 1239
            V +R  ++  +FT RE+  LD    E    + E  ++  E  M
Sbjct: 987  VFVRK-LMDLLFTKRELSWLDDLMPESKKKKLEDAEKEEEQSM 1028


>gi|197927160 solute carrier family 4, sodium bicarbonate
            cotransporter, member 4 isoform 3 [Homo sapiens]
          Length = 1094

 Score =  658 bits (1697), Expect = 0.0
 Identities = 376/945 (39%), Positives = 552/945 (58%), Gaps = 63/945 (6%)

Query: 320  PHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 379
            P ++F EL+ELL    QE +W+ETARWIKFEE VE+  ERW KPHVA+LS  SL ELR  
Sbjct: 105  PPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTC 164

Query: 380  LAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFP 439
            +  G+++LD +  +LP +   +V+  + +  +K E +  V   LL KH H + + +    
Sbjct: 165  MEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLR-- 222

Query: 440  RNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSK 499
               S   +G  +         ++P    P M     T   +    + P           K
Sbjct: 223  ---SLADIGKTVSS--ASRMFTNPDNGSPAMTHRNLTSSSLNDISDKP----------EK 267

Query: 500  SKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLL 559
             + + K ++K+P +AEA+ VLVG V+FL  P +AFVRL++AV L A+ EVPVP RFLF+L
Sbjct: 268  DQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFIL 327

Query: 560  LGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQG 619
            LGP      YHEIGR+I+TLMSD+ FH+ AY A +R DL+  I+ FLD  +VLPP E   
Sbjct: 328  LGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDP 387

Query: 620  EELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTG 679
               +           +K    G       G  P               G  + + L+RTG
Sbjct: 388  AIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGG-------GGHGDCEELQRTG 440

Query: 680  RPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIG 739
            R  GGLI+D++R+ P + SDF DAL+ Q L+A++FIY A ++ AITFGGLLG+ T ++ G
Sbjct: 441  RFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQG 500

Query: 740  VSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFW 799
            V E  + TA+ G +FCL   QPL ++  +GP+LVFE   F+F   N+ +YL  R+WIG W
Sbjct: 501  VLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLW 560

Query: 800  LVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHG----- 854
              FL L++VA + SFLV++ +RFT+E F+ LIS IFIY+ F K++K+   +P++      
Sbjct: 561  SAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVG 620

Query: 855  --------CSASNSSEVDGGENMTWAGAR-PTLGPGNR--------SLAGQSGQGKPRGQ 897
                    C   + + +    + T A    PT+   +         +   +    K  G 
Sbjct: 621  YNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGN 680

Query: 898  ---------PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMV 948
                     P+  L+S +L  GT+  +  L+KFK S +FP   R++I DF + ++ILI  
Sbjct: 681  LVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFC 740

Query: 949  LVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILI 1008
            ++D ++    T KL VPS F  T+P  RGW + P GE    P W+ +A+ +PA+LV ILI
Sbjct: 741  VID-ALVGVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN---PWWVCLAAAIPALLVTILI 795

Query: 1009 FMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANAL 1068
            FM+ QIT +I+++KE  L+KG+G+HLDL  +  +  IC+L  LPW  AATV S+ H ++L
Sbjct: 796  FMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSL 855

Query: 1069 TVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVT 1128
             + ++  APG++PK   V+EQRVTG LV +L GLS+ +  +L+ IP+ VL+G+FLYMGV 
Sbjct: 856  KMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVA 915

Query: 1129 SLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLA 1188
            SLNG+QF +RL LLLMP KH PD  Y++ V   R+HLFT LQ+LCLALLW + ST A++ 
Sbjct: 916  SLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAII 975

Query: 1189 FPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDE 1233
            FP +++  V +R   +  +F+  ++  LD  +  P  D+++  DE
Sbjct: 976  FPVMILALVAVRK-GMDYLFSQHDLSFLD--DVIPEKDKKKKEDE 1017


>gi|4507025 solute carrier family 4, sodium bicarbonate cotransporter,
            member 4 isoform 2 [Homo sapiens]
          Length = 1035

 Score =  658 bits (1697), Expect = 0.0
 Identities = 376/945 (39%), Positives = 552/945 (58%), Gaps = 63/945 (6%)

Query: 320  PHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 379
            P ++F EL+ELL    QE +W+ETARWIKFEE VE+  ERW KPHVA+LS  SL ELR  
Sbjct: 61   PPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTC 120

Query: 380  LAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFP 439
            +  G+++LD +  +LP +   +V+  + +  +K E +  V   LL KH H + + +    
Sbjct: 121  MEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLR-- 178

Query: 440  RNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSK 499
               S   +G  +         ++P    P M     T   +    + P           K
Sbjct: 179  ---SLADIGKTVSS--ASRMFTNPDNGSPAMTHRNLTSSSLNDISDKP----------EK 223

Query: 500  SKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLL 559
             + + K ++K+P +AEA+ VLVG V+FL  P +AFVRL++AV L A+ EVPVP RFLF+L
Sbjct: 224  DQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFIL 283

Query: 560  LGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQG 619
            LGP      YHEIGR+I+TLMSD+ FH+ AY A +R DL+  I+ FLD  +VLPP E   
Sbjct: 284  LGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDP 343

Query: 620  EELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTG 679
               +           +K    G       G  P               G  + + L+RTG
Sbjct: 344  AIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGG-------GGHGDCEELQRTG 396

Query: 680  RPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIG 739
            R  GGLI+D++R+ P + SDF DAL+ Q L+A++FIY A ++ AITFGGLLG+ T ++ G
Sbjct: 397  RFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQG 456

Query: 740  VSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFW 799
            V E  + TA+ G +FCL   QPL ++  +GP+LVFE   F+F   N+ +YL  R+WIG W
Sbjct: 457  VLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLW 516

Query: 800  LVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHG----- 854
              FL L++VA + SFLV++ +RFT+E F+ LIS IFIY+ F K++K+   +P++      
Sbjct: 517  SAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVG 576

Query: 855  --------CSASNSSEVDGGENMTWAGAR-PTLGPGNR--------SLAGQSGQGKPRGQ 897
                    C   + + +    + T A    PT+   +         +   +    K  G 
Sbjct: 577  YNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGN 636

Query: 898  ---------PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMV 948
                     P+  L+S +L  GT+  +  L+KFK S +FP   R++I DF + ++ILI  
Sbjct: 637  LVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFC 696

Query: 949  LVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILI 1008
            ++D ++    T KL VPS F  T+P  RGW + P GE    P W+ +A+ +PA+LV ILI
Sbjct: 697  VID-ALVGVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN---PWWVCLAAAIPALLVTILI 751

Query: 1009 FMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANAL 1068
            FM+ QIT +I+++KE  L+KG+G+HLDL  +  +  IC+L  LPW  AATV S+ H ++L
Sbjct: 752  FMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSL 811

Query: 1069 TVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVT 1128
             + ++  APG++PK   V+EQRVTG LV +L GLS+ +  +L+ IP+ VL+G+FLYMGV 
Sbjct: 812  KMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVA 871

Query: 1129 SLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLA 1188
            SLNG+QF +RL LLLMP KH PD  Y++ V   R+HLFT LQ+LCLALLW + ST A++ 
Sbjct: 872  SLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAII 931

Query: 1189 FPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDE 1233
            FP +++  V +R   +  +F+  ++  LD  +  P  D+++  DE
Sbjct: 932  FPVMILALVAVRK-GMDYLFSQHDLSFLD--DVIPEKDKKKKEDE 973


>gi|148596928 solute carrier family 4, sodium bicarbonate
            cotransporter, member 4 isoform 1 [Homo sapiens]
          Length = 1079

 Score =  658 bits (1697), Expect = 0.0
 Identities = 376/945 (39%), Positives = 552/945 (58%), Gaps = 63/945 (6%)

Query: 320  PHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 379
            P ++F EL+ELL    QE +W+ETARWIKFEE VE+  ERW KPHVA+LS  SL ELR  
Sbjct: 105  PPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTC 164

Query: 380  LAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFP 439
            +  G+++LD +  +LP +   +V+  + +  +K E +  V   LL KH H + + +    
Sbjct: 165  MEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLR-- 222

Query: 440  RNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSK 499
               S   +G  +         ++P    P M     T   +    + P           K
Sbjct: 223  ---SLADIGKTVSS--ASRMFTNPDNGSPAMTHRNLTSSSLNDISDKP----------EK 267

Query: 500  SKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLL 559
             + + K ++K+P +AEA+ VLVG V+FL  P +AFVRL++AV L A+ EVPVP RFLF+L
Sbjct: 268  DQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFIL 327

Query: 560  LGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQG 619
            LGP      YHEIGR+I+TLMSD+ FH+ AY A +R DL+  I+ FLD  +VLPP E   
Sbjct: 328  LGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDP 387

Query: 620  EELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTG 679
               +           +K    G       G  P               G  + + L+RTG
Sbjct: 388  AIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGG-------GGHGDCEELQRTG 440

Query: 680  RPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIG 739
            R  GGLI+D++R+ P + SDF DAL+ Q L+A++FIY A ++ AITFGGLLG+ T ++ G
Sbjct: 441  RFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQG 500

Query: 740  VSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFW 799
            V E  + TA+ G +FCL   QPL ++  +GP+LVFE   F+F   N+ +YL  R+WIG W
Sbjct: 501  VLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLW 560

Query: 800  LVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHG----- 854
              FL L++VA + SFLV++ +RFT+E F+ LIS IFIY+ F K++K+   +P++      
Sbjct: 561  SAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVG 620

Query: 855  --------CSASNSSEVDGGENMTWAGAR-PTLGPGNR--------SLAGQSGQGKPRGQ 897
                    C   + + +    + T A    PT+   +         +   +    K  G 
Sbjct: 621  YNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGN 680

Query: 898  ---------PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMV 948
                     P+  L+S +L  GT+  +  L+KFK S +FP   R++I DF + ++ILI  
Sbjct: 681  LVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFC 740

Query: 949  LVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILI 1008
            ++D ++    T KL VPS F  T+P  RGW + P GE    P W+ +A+ +PA+LV ILI
Sbjct: 741  VID-ALVGVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN---PWWVCLAAAIPALLVTILI 795

Query: 1009 FMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANAL 1068
            FM+ QIT +I+++KE  L+KG+G+HLDL  +  +  IC+L  LPW  AATV S+ H ++L
Sbjct: 796  FMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSL 855

Query: 1069 TVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVT 1128
             + ++  APG++PK   V+EQRVTG LV +L GLS+ +  +L+ IP+ VL+G+FLYMGV 
Sbjct: 856  KMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVA 915

Query: 1129 SLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLA 1188
            SLNG+QF +RL LLLMP KH PD  Y++ V   R+HLFT LQ+LCLALLW + ST A++ 
Sbjct: 916  SLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAII 975

Query: 1189 FPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDE 1233
            FP +++  V +R   +  +F+  ++  LD  +  P  D+++  DE
Sbjct: 976  FPVMILALVAVRK-GMDYLFSQHDLSFLD--DVIPEKDKKKKEDE 1017


>gi|19743827 sodium bicarbonate transporter 4 isoform c [Homo sapiens]
          Length = 1121

 Score =  603 bits (1556), Expect = e-172
 Identities = 369/987 (37%), Positives = 550/987 (55%), Gaps = 104/987 (10%)

Query: 300  GREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETER 359
            G E   P PT             +F E++ L  D +Q  +W+E+ARWIKFEE VEE  ER
Sbjct: 103  GEEDEAPNPT-------------LFTEMDTLQHDGDQM-EWKESARWIKFEEKVEEGGER 148

Query: 360  WGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANV 419
            W KPHV++LS  SL ELR  L  G VLLDLD  +LP +   V+E+ +    ++ E R  V
Sbjct: 149  WSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERV 208

Query: 420  LRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDP------HVTEPLM--G 471
               LL +H H + +     P + S   +G  +   +   A S        H TE L    
Sbjct: 209  SYVLLRRHRHQTKK-----PIHRSLADIGKSVSTTNRSPARSPGAGPSLHHSTEDLRMRQ 263

Query: 472  GVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPT 531
                 RL   + R +        +T +  + + K ++KIP+++EA+ VLVG V+FL +P 
Sbjct: 264  SANYGRLCHAQSRSMND----ISLTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPF 319

Query: 532  MAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYL 591
            +AFVRL ++  L  V EVPVP RFLF+LLGPS     Y+EIGR+I+TLM D  F + AY 
Sbjct: 320  IAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYK 379

Query: 592  ADEREDLLTAINAFLDCSVVLPPSE----VQGEELLRSVAHFQRQMLKKREEQGRL---- 643
            A  REDL+  I+ FLD  +VLPP E    ++ E   +  +  +R+ +    E G++    
Sbjct: 380  ARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSV 439

Query: 644  -----LPTGA----------------GLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPF 682
                  P G                 G    S+ D   +  +   G    + L  TGR F
Sbjct: 440  GGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIG----EELIWTGRFF 495

Query: 683  GGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSE 742
            GGL  D++R+ P + SDF D    Q ++A++FIY   ++ AITFGGLLG+ T +  GV E
Sbjct: 496  GGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVME 555

Query: 743  LIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVF 802
              + TA+ G +FCL   QPL+++  +GP+L+FE+  F F   N L+Y+  R+WIG     
Sbjct: 556  SFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAV 615

Query: 803  LALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSE 862
              L++VA + SF++++++RFT+E F+ LIS IFIY+   K++  F+ +P++     N   
Sbjct: 616  QCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFIT 675

Query: 863  VDGGE-------NMTWAGARPTLGPGNR-----------------------SLAGQSGQG 892
                E       N T   A   L P                          S  G+    
Sbjct: 676  TYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLLSKKECLSYGGRLLGN 735

Query: 893  KPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVD- 951
              +  P+ AL+S +L  GT+ +   L+KFK SR+FP ++R ++ DF +  +IL+   +D 
Sbjct: 736  SCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDA 795

Query: 952  -YSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFM 1010
             + +E   T KL VPS    T P+ RGW + P G+    P W+  AS+LPA+LV ILIFM
Sbjct: 796  CFGLE---TPKLHVPSVIKPTRPD-RGWFVAPFGKN---PWWVYPASILPALLVTILIFM 848

Query: 1011 ETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTV 1070
            + QIT +I+++KE  L+K +G+HLDL  +  +  +C+  GLPW  AATV S+ H ++L +
Sbjct: 849  DQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKM 908

Query: 1071 MSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSL 1130
             ++  APG++P+   V+EQRVTG++V +L G+S+ +  +L+ IPL VL+G+FLYMGV SL
Sbjct: 909  ETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMGVASL 968

Query: 1131 NGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFP 1190
            NGIQF+ER  L LMP KH PD  +++ V   R+HLFT +Q+LCLA+LW + ST A++ FP
Sbjct: 969  NGIQFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFP 1028

Query: 1191 FILILTVPLRMVVLTRIFTDREMKCLD 1217
             ++IL + +   +L  IF+  ++  +D
Sbjct: 1029 -VMILGLIIVRRLLDFIFSQHDLAWID 1054


>gi|125987596 sodium bicarbonate transporter 4 isoform a [Homo
            sapiens]
          Length = 1137

 Score =  593 bits (1529), Expect = e-169
 Identities = 369/1003 (36%), Positives = 550/1003 (54%), Gaps = 120/1003 (11%)

Query: 300  GREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETER 359
            G E   P PT             +F E++ L  D +Q  +W+E+ARWIKFEE VEE  ER
Sbjct: 103  GEEDEAPNPT-------------LFTEMDTLQHDGDQM-EWKESARWIKFEEKVEEGGER 148

Query: 360  WGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANV 419
            W KPHV++LS  SL ELR  L  G VLLDLD  +LP +   V+E+ +    ++ E R  V
Sbjct: 149  WSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERV 208

Query: 420  LRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDP------HVTEPLM--G 471
               LL +H H + +     P + S   +G  +   +   A S        H TE L    
Sbjct: 209  SYVLLRRHRHQTKK-----PIHRSLADIGKSVSTTNRSPARSPGAGPSLHHSTEDLRMRQ 263

Query: 472  GVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPT 531
                 RL   + R +        +T +  + + K ++KIP+++EA+ VLVG V+FL +P 
Sbjct: 264  SANYGRLCHAQSRSMND----ISLTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPF 319

Query: 532  MAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYL 591
            +AFVRL ++  L  V EVPVP RFLF+LLGPS     Y+EIGR+I+TLM D  F + AY 
Sbjct: 320  IAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYK 379

Query: 592  ADEREDLLTAINAFLDCSVVLPPSE----VQGEELLRSVAHFQRQMLKKREEQGRL---- 643
            A  REDL+  I+ FLD  +VLPP E    ++ E   +  +  +R+ +    E G++    
Sbjct: 380  ARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSV 439

Query: 644  -----LPTGA----------------GLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPF 682
                  P G                 G    S+ D   +  +   G    + L  TGR F
Sbjct: 440  GGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIG----EELIWTGRFF 495

Query: 683  GGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSE 742
            GGL  D++R+ P + SDF D    Q ++A++FIY   ++ AITFGGLLG+ T +  GV E
Sbjct: 496  GGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVME 555

Query: 743  LIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVF 802
              + TA+ G +FCL   QPL+++  +GP+L+FE+  F F   N L+Y+  R+WIG     
Sbjct: 556  SFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAV 615

Query: 803  LALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSE 862
              L++VA + SF++++++RFT+E F+ LIS IFIY+   K++  F+ +P++     N   
Sbjct: 616  QCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFIT 675

Query: 863  VDGGE-------NMTWAGARPTLGPGNR-----------------------SLAGQSGQG 892
                E       N T   A   L P                          S  G+    
Sbjct: 676  TYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLLSKKECLSYGGRLLGN 735

Query: 893  KPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVD- 951
              +  P+ AL+S +L  GT+ +   L+KFK SR+FP ++R ++ DF +  +IL+   +D 
Sbjct: 736  SCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDA 795

Query: 952  -YSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFM 1010
             + +E   T KL VPS    T P+ RGW + P G+    P W+  AS+LPA+LV ILIFM
Sbjct: 796  CFGLE---TPKLHVPSVIKPTRPD-RGWFVAPFGKN---PWWVYPASILPALLVTILIFM 848

Query: 1011 ETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTV 1070
            + QIT +I+++KE  L+K +G+HLDL  +  +  +C+  GLPW  AATV S+ H ++L +
Sbjct: 849  DQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKM 908

Query: 1071 MSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSL 1130
             ++  APG++P+   V+EQRVTG++V +L G+S+ +  +L+ IPL VL+G+FLYMGV SL
Sbjct: 909  ETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMGVASL 968

Query: 1131 NGIQ----------------FYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCL 1174
            NGIQ                F+ER  L LMP KH PD  +++ V   R+HLFT +Q+LCL
Sbjct: 969  NGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCL 1028

Query: 1175 ALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKCLD 1217
            A+LW + ST A++ FP ++IL + +   +L  IF+  ++  +D
Sbjct: 1029 AVLWILKSTVAAIIFP-VMILGLIIVRRLLDFIFSQHDLAWID 1070


>gi|151101449 solute carrier family 4, sodium bicarbonate
            cotransporter, member 9 [Homo sapiens]
          Length = 959

 Score =  577 bits (1487), Expect = e-164
 Identities = 375/968 (38%), Positives = 522/968 (53%), Gaps = 110/968 (11%)

Query: 292  NAKGSTQSGREGREPGPTPRARPRAPH----------KPHEVFVELNELLLDKNQEPQWR 341
            +A  +  SG     P P     P  P           K   +F++LNELL    Q  +WR
Sbjct: 15   SAPRNIPSGELDSNPDPGTGPSPDGPSDTESKELGVPKDPLLFIQLNELL-GWPQALEWR 73

Query: 342  ETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQV 401
            ET RW+ FEE +E    RW  PHV +L+  SL +LR  LA G VLLD   Q+L  +  QV
Sbjct: 74   ETGRWVLFEEKLEVAAGRWSAPHVPTLALPSLQKLRSLLAEGLVLLDCPAQSLLELVEQV 133

Query: 402  VEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAES 461
                 +S +++ +     L+ALLL+                           H+ Q    
Sbjct: 134  TRVESLSPELRGQ-----LQALLLQRPQ------------------------HYNQTTG- 163

Query: 462  DPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLV 521
                T P  G     +     E  L          R + ++ L+  +K+P  AEA  VL 
Sbjct: 164  ----TRPCWGSTHPRKASDNEEAPL----------REQCQNPLR--QKLPPGAEAGTVLA 207

Query: 522  GCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMS 581
            G + FL++P  AFVRLR  V L ++ EV +P RF  LLLGP      YHE+GR+ + L+S
Sbjct: 208  GELGFLAQPLGAFVRLRNPVVLGSLTEVSLPSRFFCLLLGPCMLGKGYHEMGRAAAVLLS 267

Query: 582  DKQFHEAAYLADEREDLLTAINAFLDCSVVLPP------SEVQGEELLRSVAHFQRQMLK 635
            D QF  +   A    DLL A++AFL+   VLPP      + +   + L S    +R   +
Sbjct: 268  DPQFQWSVRRASNLHDLLAALDAFLEEVTVLPPGRWDPTARIPPPKCLPS--QHKRLPSQ 325

Query: 636  KREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPH 695
            +RE +G  +P        SA+D+           A    L+RTGR FGGLI+DVRR+ P 
Sbjct: 326  QREIRGPAVP-----RLTSAEDRH-----RHGPHAHSPELQRTGRLFGGLIQDVRRKVPW 375

Query: 696  YLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFC 755
            Y SDF DAL  QC +AV++IY A ++ AITFGGLLG+ T    GV E  + TA+ G  FC
Sbjct: 376  YPSDFLDALHLQCFSAVLYIYLATVTNAITFGGLLGDATDGAQGVLESFLGTAVAGAAFC 435

Query: 756  LLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFL 815
            L+  QPL ++  +GP+LVFE   FSF     L+YL  R+W+G W+    L++VA E S L
Sbjct: 436  LMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLVLVATEASVL 495

Query: 816  VRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPL-------HGCSASNSSEVDGGEN 868
            VR+ +RFT+E F  LISLIFIY+   K++ +   +P+       +GC         GG  
Sbjct: 496  VRYFTRFTEEGFCALISLIFIYDAVGKMLNLTHTYPIQKPGSSAYGCLCQYPGP--GGNE 553

Query: 869  MTWAGARPT---------LGPGNRSL-----AGQSGQGKPRGQ-----PNTALLSLVLMA 909
              W   RP          LG  N SL       + G G PRG      P+ A  SL+L  
Sbjct: 554  SQWIRTRPKDRDDIVSMDLGLINASLLPPPECTRQG-GHPRGPGCHTVPDIAFFSLLLFL 612

Query: 910  GTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFS 969
             +FF A  L+  K SRFFP  +R+ + DF   +AIL+   +D  +    T KL VP  F 
Sbjct: 613  TSFFFAMALKCVKTSRFFPSVVRKGLSDFSSVLAILLGCGLDAFL-GLATPKLMVPREFK 671

Query: 970  VTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKG 1029
             T P  RGW+++P G     P W  VA+ LPA+L+ ILIFM+ QIT +I+++ E  LQKG
Sbjct: 672  PTLPG-RGWLVSPFGAN---PWWWSVAAALPALLLSILIFMDQQITAVILNRMEYRLQKG 727

Query: 1030 SGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQ 1089
            +GFHLDL  +  +  + +  GLPW  +ATV S+ H ++L   S+A APG++P    ++EQ
Sbjct: 728  AGFHLDLFCVAVLMLLTSALGLPWYVSATVISLAHMDSLRRESRACAPGERPNFLGIREQ 787

Query: 1090 RVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHH 1149
            R+TGL+V +L G SI +  +L+ IP+ VL+GIFLYMGV +L+ IQF  R+ LLLMP KH 
Sbjct: 788  RLTGLVVFILTGASIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFTNRVKLLLMPAKHQ 847

Query: 1150 PDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFT 1209
            PD+  ++ V   R+HLFTA+QL CL LLW + ST A++ FP +L+  V +R   L R+F+
Sbjct: 848  PDLLLLRHVPLTRVHLFTAIQLACLGLLWIIKSTPAAIIFPLMLLGLVGVRK-ALERVFS 906

Query: 1210 DREMKCLD 1217
             +E+  LD
Sbjct: 907  PQELLWLD 914


>gi|134288865 solute carrier family 4, sodium bicarbonate
            cotransporter, member 7 [Homo sapiens]
          Length = 1214

 Score =  568 bits (1463), Expect = e-161
 Identities = 317/743 (42%), Positives = 447/743 (60%), Gaps = 44/743 (5%)

Query: 500  SKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLL 559
            SK ++  + KIP  AEA+ VLVG V+FL RP +AFVRL  AV L  + EVPVP RFLFLL
Sbjct: 412  SKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLL 471

Query: 560  LGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQG 619
            LGP+     YHEIGRSI+TLM+D+ FH+ AY A +R DLL+ I+ FLD   VLPP E   
Sbjct: 472  LGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDP 531

Query: 620  EELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTG 679
               +        Q  +K            G  PK A   A               L+RTG
Sbjct: 532  SIRIEPPKSVPSQEKRKIPVFHNGSTPTLGETPKEAAHHA------------GPELQRTG 579

Query: 680  RPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIG 739
            R FGGLI D++R+ P +LSDF+DAL  QCLA+++F+Y A +SP ITFGGLLGE T+  I 
Sbjct: 580  RLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRIS 639

Query: 740  VSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFW 799
              E +   +L G+ + L   QPL ++G +GP+LVFE+  + FC    L YL  R  IG W
Sbjct: 640  AIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLW 699

Query: 800  LVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKI-----FQEH---- 850
              FL +++VA + S LV +++RFT+E FA LI +IFIYE   KL  +     F  H    
Sbjct: 700  TSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLD 759

Query: 851  --------------PLHGCSASNSSEVDGGENMTWAGARPTLGPGNRS--LAGQSGQGKP 894
                          P +   A    +     N++W     +     R   L    G   P
Sbjct: 760  KLTSYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGP 819

Query: 895  RGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSI 954
               P+     ++L   TFF++ FL++FK  R+FP ++R  I DF V + I+IMV +DY +
Sbjct: 820  Y-IPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLV 878

Query: 955  EDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQI 1014
                + KL VP  F  T PE RGW+I+PLG+    P W ++ + +PA+L  ILIFM+ QI
Sbjct: 879  -GVPSPKLHVPEKFEPTHPE-RGWIISPLGDN---PWWTLLIAAIPALLCTILIFMDQQI 933

Query: 1015 TTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKA 1074
            T +II++KE  L+KG+G+HLDLL++  M G+C++ GLPW  AATV S++H N+L V S+ 
Sbjct: 934  TAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESEC 993

Query: 1075 VAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQ 1134
             APG++PK   ++EQRVTGL++ +L+GLS+ +  +L+ IP+ VL+G+FLYMGV+SL GIQ
Sbjct: 994  SAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQ 1053

Query: 1135 FYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILI 1194
             ++R+ L  MP KH PD+ Y++ V   ++H+FT +QL CL LLW +  +AA++ FP +++
Sbjct: 1054 LFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVL 1113

Query: 1195 LTVPLRMVVLTRIFTDREMKCLD 1217
              V +R  ++   FT RE+  LD
Sbjct: 1114 ALVFVRK-LMDLCFTKRELSWLD 1135



 Score =  122 bits (307), Expect = 2e-27
 Identities = 73/200 (36%), Positives = 108/200 (54%), Gaps = 18/200 (9%)

Query: 287 HLVRKNAKGSTQSGREGREPGPTPRARPR---------APHKPHEVFVELNELLLDKNQE 337
           H  RK+ +   + GRE      TP  R +           H PH++F E++EL     +E
Sbjct: 68  HRRRKDKESDKEDGRESPSYD-TPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEE 126

Query: 338 PQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGV 397
            +W+ETARW+KFEEDVE+  +RW KP+VA+LS  SL ELR  + +G V+LD+   TL  +
Sbjct: 127 YEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEI 186

Query: 398 AHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQ 457
           A  V++ M+ S Q+    R NV  ALL +H H ++++   F   I      + +G  H  
Sbjct: 187 ADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKR---FTSRIPLVRSFADIGKKH-- 241

Query: 458 GAESDPHVTEPLMGGVPETR 477
              SDPH+ E    G+  +R
Sbjct: 242 ---SDPHLLERNGEGLSASR 258


>gi|14042960 solute carrier family 4 member 11 [Homo sapiens]
          Length = 891

 Score =  251 bits (640), Expect = 4e-66
 Identities = 205/710 (28%), Positives = 323/710 (45%), Gaps = 108/710 (15%)

Query: 553  VRFLFLLLGPSS--ANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSV 610
            VRF+ L+L P    +     E+ R+ +T+ SD  F +        E+   A+        
Sbjct: 247  VRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEAL-------- 298

Query: 611  VLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAA 670
                  V   +LL  V+H      + +E     LP     EP   +D             
Sbjct: 299  ------VHQRQLLTMVSHGPVAP-RTKERSTVSLPAHRHPEPPKCKDFV----------- 340

Query: 671  EDDPLRRTGRPFG-GLIRDVRRRYPHYLSDFRDALDPQ------CLAAVIFIYFAALSPA 723
                      PFG G+  D+ RR+P Y  DF D +  +       +   +F+YFA L P 
Sbjct: 341  ----------PFGKGIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPT 390

Query: 724  ITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCS 783
            I FG L  E T   I V + I   ++ G+++ L   QPL+++  + PL ++ +     C 
Sbjct: 391  IAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICD 450

Query: 784  SNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKL 843
               L++     W G W  F   L      S ++    R T+EI A  IS+ F+ +     
Sbjct: 451  DYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKGT 510

Query: 844  VKIFQEH------------------PLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSL 885
            VKIF ++                   L G  AS ++ +    N ++  A PT  P     
Sbjct: 511  VKIFWKYYYGHYLDDYHTKRTSSLVSLSGLGASLNASLHTALNASFL-ASPTELPS---- 565

Query: 886  AGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAIL 945
            A  SGQ        TA+LSL++M GT ++ + L +FK S +    +R ++ D  +PIA+L
Sbjct: 566  ATHSGQA-------TAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVL 618

Query: 946  IMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAI--- 1002
               L+               S       E   +  NP   +SPF +  + +  L A+   
Sbjct: 619  AFSLI---------------SSHGFREIEMSKFRYNP--SESPFAMAQIQSLSLRAVSGA 661

Query: 1003 -----LVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAA 1057
                 L+ +L F+E  +   +++  E  L KG+ +H DLLL+  +    +LFGLPW+ AA
Sbjct: 662  MGLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAA 721

Query: 1058 TVRSVTHANALTVMSKAVAPGD-KPKIQEVKEQRVTGLLVALLVGLSIVIGDL-LRQIPL 1115
               S  H  AL ++ + V  G     I  VKE R+T L  ++LVGLS+++  + L+ IP 
Sbjct: 722  YPHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPK 781

Query: 1116 AVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLA 1175
             VL+G+FLY+ +TSL+G Q  +R+ LLL     +P   Y+++V   ++H FT LQ+L L 
Sbjct: 782  PVLYGLFLYIALTSLDGNQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLL 841

Query: 1176 LLWAVMSTA---ASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEAE 1222
            LL A   ++     + FP I+I  +P+R ++L RI    E K LD  +AE
Sbjct: 842  LLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRII---EAKYLDVMDAE 888


>gi|61742808 hypothetical protein LOC283638 isoform 2 [Homo sapiens]
          Length = 1484

 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 93/376 (24%), Positives = 138/376 (36%), Gaps = 87/376 (23%)

Query: 2    SSAPRRPAKGADSFCTPEP----ESLGPGTPGFP-----------EQEEDELHRTLG--- 43
            S+   R  K   S  TP+P    + + P  P              EQ  +  H  LG   
Sbjct: 890  STVSLRSGKSGPSPTTPQPLRAQKEMSPSPPAAQDPGGTALVSAREQSSERQHHPLGPTD 949

Query: 44   VERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPD---ARRRKTPQ 100
            + R E + + A  RG     R  G  D+    +       P+  HLP     A   +TP+
Sbjct: 950  MGRGEPVRRSAIRRGH----RPRGSLDWPSEERG------PVLAHLPSSDVMASNHETPE 999

Query: 101  --GPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFF--- 155
              G GR   RR  A+P   +P   E E+    AS  +G +ALT+ + +STP   +     
Sbjct: 1000 ATGAGRLGSRRKPAAPP-PSPAARE-EQSRSSASSQKGPQALTRSNSLSTPRPTRASRLR 1057

Query: 156  -LQEDDSADRKA---ERTSPSSPAPL--PHQE-----------ATPRASKGAQAGTQVEE 198
              +  D++D +A   ER S  +P P+  P  E           A PR   G+  GT   E
Sbjct: 1058 RARLGDASDTEAADGERGSLGNPEPVGRPAAEQAKKLSRLDILAMPRKRAGSFTGTSDPE 1117

Query: 199  AE----------------------AEAVAVASGTAGGDDGGASGRPLPKAQPGHRSY-NL 235
            A                       AEA AV+   A         +P  +A+ G   Y + 
Sbjct: 1118 AAPARTSFSGRSVELCCASRKPTMAEARAVSRKAANTATTTGPRQPFSRARSGSARYTST 1177

Query: 236  QERRRIGSMTGA-EQALLPRVPTDEIE--------AQTLATADLDLMKSHRFEDVPGVRR 286
             +  R GS + A  +A  PR   D+ E         QT   A++  +     +DV  + +
Sbjct: 1178 TQTPRAGSSSRARSRAPGPRDTDDDEEEPDPYGFIVQTAEIAEIARLSQTLVKDVAILAQ 1237

Query: 287  HLVRKNAKGSTQSGRE 302
             +      G T    E
Sbjct: 1238 EIHDVAGDGDTLGSSE 1253



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 42/153 (27%), Positives = 59/153 (38%), Gaps = 36/153 (23%)

Query: 5   PRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFE--EILQEAGSRGGEEP 62
           P+ P++ ADS     PES     PG PE + ++  R  G E  +   +   +GS GG  P
Sbjct: 632 PQLPSERADS--PAGPESSRRSGPGPPELDSEQPSRLFGQEELDPDSLSDASGSDGGRGP 689

Query: 63  GRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETP-TI 121
                E   E                 P D+RRR   +GP     RR   +P   TP + 
Sbjct: 690 -----EPGVE-----------------PQDSRRRSPQEGPTWSRGRRSPRAPGEPTPASF 727

Query: 122 EEGEEDEDEA---------SEAEGARALTQPSP 145
             G+++ D            + EG     QPSP
Sbjct: 728 FIGDQNGDAVLSRKPLAAPGDGEGLGQTAQPSP 760


>gi|163644261 hypothetical protein LOC283638 isoform 1 [Homo sapiens]
          Length = 1554

 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 93/376 (24%), Positives = 138/376 (36%), Gaps = 87/376 (23%)

Query: 2    SSAPRRPAKGADSFCTPEP----ESLGPGTPGFP-----------EQEEDELHRTLG--- 43
            S+   R  K   S  TP+P    + + P  P              EQ  +  H  LG   
Sbjct: 960  STVSLRSGKSGPSPTTPQPLRAQKEMSPSPPAAQDPGGTALVSAREQSSERQHHPLGPTD 1019

Query: 44   VERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPD---ARRRKTPQ 100
            + R E + + A  RG     R  G  D+    +       P+  HLP     A   +TP+
Sbjct: 1020 MGRGEPVRRSAIRRGH----RPRGSLDWPSEERG------PVLAHLPSSDVMASNHETPE 1069

Query: 101  --GPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFF--- 155
              G GR   RR  A+P   +P   E E+    AS  +G +ALT+ + +STP   +     
Sbjct: 1070 ATGAGRLGSRRKPAAPP-PSPAARE-EQSRSSASSQKGPQALTRSNSLSTPRPTRASRLR 1127

Query: 156  -LQEDDSADRKA---ERTSPSSPAPL--PHQE-----------ATPRASKGAQAGTQVEE 198
              +  D++D +A   ER S  +P P+  P  E           A PR   G+  GT   E
Sbjct: 1128 RARLGDASDTEAADGERGSLGNPEPVGRPAAEQAKKLSRLDILAMPRKRAGSFTGTSDPE 1187

Query: 199  AE----------------------AEAVAVASGTAGGDDGGASGRPLPKAQPGHRSY-NL 235
            A                       AEA AV+   A         +P  +A+ G   Y + 
Sbjct: 1188 AAPARTSFSGRSVELCCASRKPTMAEARAVSRKAANTATTTGPRQPFSRARSGSARYTST 1247

Query: 236  QERRRIGSMTGA-EQALLPRVPTDEIE--------AQTLATADLDLMKSHRFEDVPGVRR 286
             +  R GS + A  +A  PR   D+ E         QT   A++  +     +DV  + +
Sbjct: 1248 TQTPRAGSSSRARSRAPGPRDTDDDEEEPDPYGFIVQTAEIAEIARLSQTLVKDVAILAQ 1307

Query: 287  HLVRKNAKGSTQSGRE 302
             +      G T    E
Sbjct: 1308 EIHDVAGDGDTLGSSE 1323



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 42/153 (27%), Positives = 59/153 (38%), Gaps = 36/153 (23%)

Query: 5   PRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFE--EILQEAGSRGGEEP 62
           P+ P++ ADS     PES     PG PE + ++  R  G E  +   +   +GS GG  P
Sbjct: 702 PQLPSERADS--PAGPESSRRSGPGPPELDSEQPSRLFGQEELDPDSLSDASGSDGGRGP 759

Query: 63  GRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETP-TI 121
                E   E                 P D+RRR   +GP     RR   +P   TP + 
Sbjct: 760 -----EPGVE-----------------PQDSRRRSPQEGPTWSRGRRSPRAPGEPTPASF 797

Query: 122 EEGEEDEDEA---------SEAEGARALTQPSP 145
             G+++ D            + EG     QPSP
Sbjct: 798 FIGDQNGDAVLSRKPLAAPGDGEGLGQTAQPSP 830


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 70/320 (21%), Positives = 103/320 (32%), Gaps = 32/320 (10%)

Query: 18  PEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQS 77
           PEP+   P      E+E+++                + S     P R +        R  
Sbjct: 254 PEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRS------RSR 307

Query: 78  SHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGA 137
           S+      S    P  RRR  P+     PR R   SP                +S +  +
Sbjct: 308 SYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRS 367

Query: 138 RALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVE 197
           R+  +  P  T S  +   +   SA     R  PS PA        P  ++ +    Q  
Sbjct: 368 RSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPA------TPPPKTRHSPTPQQSN 421

Query: 198 EAEAEAVAVASGTAGG---DDGGASGRPLPKAQPGHRSYNLQERR--RIGSMTGAEQALL 252
                 V+V+ G   G      G   R  P   P  R   L E    + G M  A+    
Sbjct: 422 RTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQ 481

Query: 253 PR------VPTDEIEAQTLATADLDLMKSH-RFEDVPGVRRH--------LVRKNAKGST 297
            R        +      + ++ D    +SH +  +V   RRH          RK  K ++
Sbjct: 482 RRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETS 541

Query: 298 QSGREGREPGPTPRARPRAP 317
             GR  R P P P  R R+P
Sbjct: 542 PRGRRRRSPSPPPTRRRRSP 561



 Score = 34.3 bits (77), Expect = 0.76
 Identities = 53/272 (19%), Positives = 90/272 (33%), Gaps = 18/272 (6%)

Query: 53  EAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGA 112
           E G R    P RS      +  +++S       S   PP  RRR     P  + RR P  
Sbjct: 516 EVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTP 575

Query: 113 SPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPS 172
            P   TP+             +   +    PSP     +                R SPS
Sbjct: 576 PPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTA-------SPPPPPKRRASPS 628

Query: 173 SP-------APLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPK 225
            P       +P P Q ++P  +K        +  +  + + ++  A          P P+
Sbjct: 629 PPPKRRVSHSPPPKQRSSP-VTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPR 687

Query: 226 AQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVR 285
            +    S +    RR G+ +  ++   P   T  I  +   T +   +K         VR
Sbjct: 688 PRAPQTSSSPPPVRR-GASSSPQRRQSPSPSTRPIR-RVSRTPEPKKIKKAASPSPQSVR 745

Query: 286 RHLVRKNAKGSTQSGREGREPGPTPRARPRAP 317
           R    ++  GS +   + + P P    + ++P
Sbjct: 746 RVSSSRSVSGSPEPAAK-KPPAPPSPVQSQSP 776


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
            sapiens]
          Length = 2715

 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 38/140 (27%), Positives = 53/140 (37%), Gaps = 27/140 (19%)

Query: 18   PEPESLGPG------TPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDF 71
            P PE LGP         G    + D     LG E F+E +  AG+ G    G   G+   
Sbjct: 1968 PPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGP--GDSSE 2025

Query: 72   EYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEA 131
            E    +S +IH P++               PG  P   PGA    +   +++G + E   
Sbjct: 2026 EESSPTSRYIHFPVTV-----------VSAPGLAPSATPGAPRIEQLDGVDDGTDSE--- 2071

Query: 132  SEAEGARALTQPSPVSTPSS 151
                 A A+ QP    TP S
Sbjct: 2072 -----AEAVQQPRGQGTPPS 2086


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score = 43.9 bits (102), Expect = 0.001
 Identities = 66/288 (22%), Positives = 108/288 (37%), Gaps = 34/288 (11%)

Query: 90  PPDARRRKTPQGPGRK--PRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVS 147
           PP  +    P GP  +  P +RP     G   ++++       A  A        P+P +
Sbjct: 549 PPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDPDPAIPAPTA 608

Query: 148 TPSSVQFFLQEDDSADRKAERTSPSSPAPL-PHQEATPRASKGAQAGTQVEEAEAEAVAV 206
           TPS+    ++++     +    SP+ PA + P  EA P+           +   + A A+
Sbjct: 609 TPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVP---------QRTSSIATAL 659

Query: 207 ASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLA 266
            +  AGG     + R  P++    + Y LQ R   G+         P  P +      L 
Sbjct: 660 NTSGAGGSRPAQAVRARPRSNSAWQIY-LQRRAERGTPKPPGPPAQPPGPPNASSNPDLR 718

Query: 267 TADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREG--REPGPTPRARPRAPHKPHE-- 322
            +D    +S     +P    HL +    GS +  R G   +P  +P   P    KP +  
Sbjct: 719 RSDPGWERSDSV--LPASHGHLPQ---AGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHR 773

Query: 323 -------VFVELNELLLDKNQEP-----QWRETARWIKFEEDVEEETE 358
                   FV L E  LD+   P      +  ++  ++  ED EEE E
Sbjct: 774 SRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGE 821


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score = 43.9 bits (102), Expect = 0.001
 Identities = 68/297 (22%), Positives = 114/297 (38%), Gaps = 38/297 (12%)

Query: 84  PLSTHLPPDARRRKTPQGPGR-----KPRRRPGASPTGETPTIEEGEEDEDEASEAEGAR 138
           PLS   PP  R  +  +GP +     +   +P A+P   + ++++       A  A    
Sbjct: 561 PLS-QTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDP 619

Query: 139 ALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPL-PHQEATPRASKGAQAGTQVE 197
               P+P +TPS+    ++++     +    SP+ PA + P  EA P+           +
Sbjct: 620 DPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVP---------Q 670

Query: 198 EAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPT 257
              + A A+ +  AGG     + R  P++    + Y LQ R   G+         P  P 
Sbjct: 671 RTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIY-LQRRAERGTPKPPGPPAQPPGPP 729

Query: 258 DEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREG--REPGPTPRARPR 315
           +      L  +D    +S     +P    HL +    GS +  R G   +P  +P   P 
Sbjct: 730 NASSNPDLRRSDPGWERSDSV--LPASHGHLPQ---AGSLERNRVGVSSKPDSSPVLSPG 784

Query: 316 APHKPHE---------VFVELNELLLDKNQEP-----QWRETARWIKFEEDVEEETE 358
              KP +          FV L E  LD+   P      +  ++  ++  ED EEE E
Sbjct: 785 NKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGE 841


>gi|195963316 PWWP domain containing 2A isoform b [Homo sapiens]
          Length = 755

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 45/170 (26%), Positives = 65/170 (38%), Gaps = 6/170 (3%)

Query: 112 ASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVS-TPSSVQFFLQEDDSADRKAERTS 170
           A+ T  +P      E E E     G+ A T P PV+ T +SV     E D      +   
Sbjct: 8   AAATAASPGEGGAGEAEPEMEPIPGSEAGTDPLPVTATEASVPD--GETDGQQSAPQADE 65

Query: 171 PSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGH 230
           P  P P P      R+ +    G ++E  E  +V VA   A    GG    P P A P  
Sbjct: 66  PPLPPPPPPPGELARSPEAV--GPELEAEEKLSVRVAESAAAAPQGGPELPPSP-ASPPE 122

Query: 231 RSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFED 280
           +    +ER           AL+P    D   +Q +  +++ +   H  ED
Sbjct: 123 QPPAPEEREEPPLPQPVAPALVPPAGGDSTVSQLIPGSEVRVTLDHIIED 172


>gi|153791982 PWWP domain containing 2A isoform a [Homo sapiens]
          Length = 560

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 45/170 (26%), Positives = 65/170 (38%), Gaps = 6/170 (3%)

Query: 112 ASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVS-TPSSVQFFLQEDDSADRKAERTS 170
           A+ T  +P      E E E     G+ A T P PV+ T +SV     E D      +   
Sbjct: 8   AAATAASPGEGGAGEAEPEMEPIPGSEAGTDPLPVTATEASVPD--GETDGQQSAPQADE 65

Query: 171 PSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGH 230
           P  P P P      R+ +    G ++E  E  +V VA   A    GG    P P A P  
Sbjct: 66  PPLPPPPPPPGELARSPEAV--GPELEAEEKLSVRVAESAAAAPQGGPELPPSP-ASPPE 122

Query: 231 RSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFED 280
           +    +ER           AL+P    D   +Q +  +++ +   H  ED
Sbjct: 123 QPPAPEEREEPPLPQPVAPALVPPAGGDSTVSQLIPGSEVRVTLDHIIED 172


>gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
          Length = 1342

 Score = 42.0 bits (97), Expect = 0.004
 Identities = 52/199 (26%), Positives = 68/199 (34%), Gaps = 24/199 (12%)

Query: 3    SAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEP 62
            S       G+   C P P SL P   G    E  E H T      +E +    SR     
Sbjct: 1065 SCQESAVSGSSERC-PRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRS 1123

Query: 63   GRSYGEEDFEYHRQSSHHIHHPLST----------HLPPDARRRKTPQGPGRKPRRRPGA 112
             R  G+  +   R S      PLS           ++ PD   + TP        R    
Sbjct: 1124 PRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSS------REGTL 1177

Query: 113  SPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQE------DDSADRKA 166
            S  G +  +   EEDEDE  E    R    P     PSS++    E      D SA   +
Sbjct: 1178 SSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGS 1237

Query: 167  ERTSPSSPAP-LPHQEATP 184
             ++ P  P P +P    TP
Sbjct: 1238 TQSCPLHPVPIMPTAGTTP 1256


>gi|166795264 AE binding protein 2 isoform b [Homo sapiens]
          Length = 517

 Score = 42.0 bits (97), Expect = 0.004
 Identities = 38/161 (23%), Positives = 64/161 (39%), Gaps = 37/161 (22%)

Query: 96  RKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEG------------------- 136
           R +P  PG      PG++  G     EE EE+E+E  EAE                    
Sbjct: 16  RLSPLPPGS-----PGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGG 70

Query: 137 --------ARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASK 188
                   A  +++PSP S   + +   +E+D  + + E +S         +E++  +  
Sbjct: 71  GGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGG----GEEESSAESLV 126

Query: 189 GAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPG 229
           G+  G+  +E  + +   AS ++ GD  G  G   PK   G
Sbjct: 127 GSSGGSSSDETRSLSPGAAS-SSSGDGDGKEGLEEPKGPRG 166


>gi|166795262 AE binding protein 2 isoform a [Homo sapiens]
          Length = 503

 Score = 42.0 bits (97), Expect = 0.004
 Identities = 38/161 (23%), Positives = 64/161 (39%), Gaps = 37/161 (22%)

Query: 96  RKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEG------------------- 136
           R +P  PG      PG++  G     EE EE+E+E  EAE                    
Sbjct: 16  RLSPLPPGS-----PGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGG 70

Query: 137 --------ARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASK 188
                   A  +++PSP S   + +   +E+D  + + E +S         +E++  +  
Sbjct: 71  GGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGG----GEEESSAESLV 126

Query: 189 GAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPG 229
           G+  G+  +E  + +   AS ++ GD  G  G   PK   G
Sbjct: 127 GSSGGSSSDETRSLSPGAAS-SSSGDGDGKEGLEEPKGPRG 166


>gi|59806361 hypothetical protein LOC387104 [Homo sapiens]
          Length = 947

 Score = 41.2 bits (95), Expect = 0.006
 Identities = 62/290 (21%), Positives = 97/290 (33%), Gaps = 9/290 (3%)

Query: 7   RPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSY 66
           +P  GA++       +LG   PG PE+   EL            L E G  GGE  G   
Sbjct: 119 QPVAGAEAAPAATLAALGGRRPGPPEEPPRELESVPSKLGEPPPLGEGGGGGGEGGGAGG 178

Query: 67  GEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEE 126
           G  +    R+       P         R ++     G      P +S  G+TP       
Sbjct: 179 GSGE----REGGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGTGSRNS 234

Query: 127 DEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRA 186
               A    G               +QF L+++ +A   A     +         ++P +
Sbjct: 235 GSGVAGGGSGGGGSYWKEGCLQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVS 294

Query: 187 SKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTG 246
              A   T    + +   A A G     +G ASG  +  A P     + Q+ +    M  
Sbjct: 295 GPPAVCETLAVASASPMAAAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQE 354

Query: 247 AEQALLPRVPTDEIEAQTLATADLDLMKSHRFED----VPGVRRHLVRKN 292
             + L     T + E   L T ++D M+   FE+    +  +R  L R N
Sbjct: 355 EMEKLREENETLKNEIDELRT-EMDEMRDTFFEEDACQLQEMRHELERAN 403


>gi|91208420 bassoon protein [Homo sapiens]
          Length = 3926

 Score = 41.2 bits (95), Expect = 0.006
 Identities = 80/340 (23%), Positives = 123/340 (36%), Gaps = 35/340 (10%)

Query: 95  RRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQF 154
           ++K PQG G+      G  P   +P   +      +AS    A+ L    P  TPSSVQ 
Sbjct: 554 KQKGPQGLGQPS----GPLPAKASPLSTKASPLPSKASPQ--AKPLRASEPSKTPSSVQ- 606

Query: 155 FLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGD 214
             ++      KAE      P P P    TP   K      + E A     AV     GG+
Sbjct: 607 --EKKTRVPTKAE----PMPKPPPETTPTPATPKVKSGVRRAEPATPVVKAVPEAPKGGE 660

Query: 215 DGGASGRPLPKAQPGHRS-YNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLA--TADLD 271
                G+P   +Q   RS  +L +         + Q+ +  V   E+E    A  T    
Sbjct: 661 AEDLVGKPY--SQDASRSPQSLSDTGYSSDGISSSQSEITGVVQQEVEQLDSAGVTGPHP 718

Query: 272 LMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHKPHEVF---VELN 328
              S   +    +R  L  +    S +S       G   + RP +     E F    EL 
Sbjct: 719 PSPSEIHKVGSSMRPLLQAQGLAPSERSKPLSSGTGEEQKQRPHSLSITPEAFDSDEELE 778

Query: 329 ELLLDKNQEPQWRETARWIKFEEDVEEETERWGK----PHVASLSFRSLLEL-RRTLAHG 383
           ++L +     +WR      + ++D  E ++ +G      +V   S   L  L  +  A  
Sbjct: 779 DILEEDEDSAEWRRR----REQQDTAESSDDFGSQLRHDYVEDSSEGGLSPLPPQPPARA 834

Query: 384 AVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRAL 423
           A L D D      +  Q++E     D ++ +D A   R L
Sbjct: 835 AELTDED-----FMRRQILEMSAEEDNLEEDDTATSGRGL 869



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 55/216 (25%), Positives = 75/216 (34%), Gaps = 12/216 (5%)

Query: 44  VERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPG 103
           V++  E L  AG  G   P  S      E H+  S       +  L P  R +    G G
Sbjct: 701 VQQEVEQLDSAGVTGPHPPSPS------EIHKVGSSMRPLLQAQGLAPSERSKPLSSGTG 754

Query: 104 RKPRRRPGA-SPTGETPTIEEGEED--EDEASEAEGARALTQPSPVSTPSSVQFFLQEDD 160
            + ++RP + S T E    +E  ED  E++   AE  R   Q     +       L+ D 
Sbjct: 755 EEQKQRPHSLSITPEAFDSDEELEDILEEDEDSAEWRRRREQQDTAESSDDFGSQLRHDY 814

Query: 161 SADRKAERTSPSSPAPLPHQ-EATPRASKGAQAGTQVEEAE--AEAVAVASGTAGGDDGG 217
             D      SP  P P     E T       Q      E +   E     SG      G 
Sbjct: 815 VEDSSEGGLSPLPPQPPARAAELTDEDFMRRQILEMSAEEDNLEEDDTATSGRGLAKHGT 874

Query: 218 ASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLP 253
             G P P+ +P      L +RR   + T   + LLP
Sbjct: 875 QKGGPRPRPEPSQEPAALPKRRLPHNATTGYEELLP 910



 Score = 31.2 bits (69), Expect = 6.4
 Identities = 31/134 (23%), Positives = 45/134 (33%), Gaps = 21/134 (15%)

Query: 91  PDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEED---EDEASEAEGARALTQPSPVS 147
           P ++ ++    P   P   P   P G+ P  E        +  + +AE ARA + P P  
Sbjct: 234 PRSKSQQQLHSPALSPAHSPAKQPLGK-PDQERSRGPGGPQPGSRQAETARATSVPGPAQ 292

Query: 148 TPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVA 207
                        +A  +  R SP  P P     A PR   G     +     A AV   
Sbjct: 293 A------------AAPPEVGRVSPQPPQPTKPSTAEPRPPAG-----EAPAKSATAVPAG 335

Query: 208 SGTAGGDDGGASGR 221
            G       G +G+
Sbjct: 336 LGATEQTQEGLTGK 349


>gi|4502805 chromogranin A precursor [Homo sapiens]
          Length = 457

 Score = 40.8 bits (94), Expect = 0.008
 Identities = 57/267 (21%), Positives = 96/267 (35%), Gaps = 47/267 (17%)

Query: 122 EEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQE 181
           E  E  E+++S+AE   A+ +PS       V    ++   A++  E T  + P  LP   
Sbjct: 103 ELSEVLENQSSQAELKEAVEEPSS----KDVMEKREDSKEAEKSGEATDGARPQALPEPM 158

Query: 182 ATPRASKGAQAGTQVEEAEAEAVAV-----------ASGTAGGDDGGASGRPLPK----- 225
              +A    QA  + EE E EA                  A GD  G S   + +     
Sbjct: 159 QESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLS 218

Query: 226 AQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVR 285
           A+PG ++   +E          E+A+       E E  T+      ++  H       +R
Sbjct: 219 AEPGWQAKREEEEEEEEEAEAGEEAV------PEEEGPTV------VLNPHPSLGYKEIR 266

Query: 286 RHLVRKNAKGSTQSGREGREPGPTPRARPRAPHK------------PHEVFVELNELLLD 333
           +   R  A     +G+ G E    P  +    H             P  +F       L+
Sbjct: 267 KGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELE 326

Query: 334 KNQE---PQWRETARWIKFEEDVEEET 357
           + +E    +W ++ RW K ++  +E T
Sbjct: 327 QEEERLSKEWEDSKRWSKMDQLAKELT 353



 Score = 37.7 bits (86), Expect = 0.069
 Identities = 40/171 (23%), Positives = 65/171 (38%), Gaps = 5/171 (2%)

Query: 49  EILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQG--PGRKP 106
           E +QE+ + G  +   + GEE+ E    ++ H    L +   P  +     +G   G   
Sbjct: 156 EPMQESKAEGNNQ---APGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVD 212

Query: 107 RRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKA 166
           R +  ++  G     EE EE+E+EA   E A    +   V          +E    + ++
Sbjct: 213 REKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRS 272

Query: 167 ERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGG 217
           E  +         +EA     KG Q  +Q +E E E   V  G   G   G
Sbjct: 273 EALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSG 323


>gi|239754674 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 480

 Score = 40.8 bits (94), Expect = 0.008
 Identities = 36/136 (26%), Positives = 54/136 (39%), Gaps = 7/136 (5%)

Query: 118 TPTIEEGEEDEDEASEA----EGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSS 173
           TP  +EG       S+     E A    QP P + P+ V+   + + ++     R+  + 
Sbjct: 182 TPPRQEGSFGGRPKSQPPLPQETAAPAPQPGPTAPPARVREPGRAEGASREPRLRSRAAR 241

Query: 174 PAPLPHQEATPRASKGAQAGTQ---VEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGH 230
           P P P   A  RAS+   AG         E  A   A G  GG + GA GR  P ++   
Sbjct: 242 PPPAPGPGALSRASRSRAAGRPGPGFHGGEKAAAPRAPGGGGGRNPGALGRAAPPSRARQ 301

Query: 231 RSYNLQERRRIGSMTG 246
            ++ L     +G   G
Sbjct: 302 DAWGLSGCATVGLRRG 317


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,374,365
Number of Sequences: 37866
Number of extensions: 2655172
Number of successful extensions: 16514
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 453
Number of HSP's that attempted gapping in prelim test: 14935
Number of HSP's gapped (non-prelim): 1780
length of query: 1241
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1127
effective length of database: 13,930,794
effective search space: 15700004838
effective search space used: 15700004838
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press