BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|156071474 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) [Homo sapiens] (1241 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|156071474 solute carrier family 4, anion exchanger, member 2 ... 2462 0.0 gi|157671951 solute carrier family 4, anion exchanger, member 3 ... 1359 0.0 gi|157671953 solute carrier family 4, anion exchanger, member 3 ... 1355 0.0 gi|4507021 solute carrier family 4, anion exchanger, member 1 [H... 1011 0.0 gi|90403614 solute carrier family 4, sodium bicarbonate cotransp... 679 0.0 gi|90568034 solute carrier family 4, sodium bicarbonate cotransp... 679 0.0 gi|155722998 solute carrier family 4, sodium bicarbonate transpo... 673 0.0 gi|197927160 solute carrier family 4, sodium bicarbonate cotrans... 658 0.0 gi|4507025 solute carrier family 4, sodium bicarbonate cotranspo... 658 0.0 gi|148596928 solute carrier family 4, sodium bicarbonate cotrans... 658 0.0 gi|19743827 sodium bicarbonate transporter 4 isoform c [Homo sap... 603 e-172 gi|125987596 sodium bicarbonate transporter 4 isoform a [Homo sa... 593 e-169 gi|151101449 solute carrier family 4, sodium bicarbonate cotrans... 577 e-164 gi|134288865 solute carrier family 4, sodium bicarbonate cotrans... 568 e-161 gi|14042960 solute carrier family 4 member 11 [Homo sapiens] 251 4e-66 gi|61742808 hypothetical protein LOC283638 isoform 2 [Homo sapiens] 46 3e-04 gi|163644261 hypothetical protein LOC283638 isoform 1 [Homo sapi... 46 3e-04 gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 45 3e-04 gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 45 6e-04 gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 44 0.001 gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 44 0.001 gi|195963316 PWWP domain containing 2A isoform b [Homo sapiens] 43 0.002 gi|153791982 PWWP domain containing 2A isoform a [Homo sapiens] 43 0.002 gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens] 42 0.004 gi|166795264 AE binding protein 2 isoform b [Homo sapiens] 42 0.004 gi|166795262 AE binding protein 2 isoform a [Homo sapiens] 42 0.004 gi|59806361 hypothetical protein LOC387104 [Homo sapiens] 41 0.006 gi|91208420 bassoon protein [Homo sapiens] 41 0.006 gi|4502805 chromogranin A precursor [Homo sapiens] 41 0.008 gi|239754674 PREDICTED: hypothetical protein [Homo sapiens] 41 0.008 >gi|156071474 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) [Homo sapiens] Length = 1241 Score = 2462 bits (6380), Expect = 0.0 Identities = 1241/1241 (100%), Positives = 1241/1241 (100%) Query: 1 MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE 60 MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE Sbjct: 1 MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE 60 Query: 61 EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT 120 EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT Sbjct: 61 EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT 120 Query: 121 IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ 180 IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ Sbjct: 121 IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ 180 Query: 181 EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR 240 EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR Sbjct: 181 EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR 240 Query: 241 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG 300 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG Sbjct: 241 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG 300 Query: 301 REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW 360 REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW Sbjct: 301 REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW 360 Query: 361 GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL 420 GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL Sbjct: 361 GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL 420 Query: 421 RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV 480 RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV Sbjct: 421 RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV 480 Query: 481 ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA 540 ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA Sbjct: 481 ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA 540 Query: 541 VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT 600 VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT Sbjct: 541 VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT 600 Query: 601 AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL 660 AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL Sbjct: 601 AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL 660 Query: 661 LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL 720 LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL Sbjct: 661 LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL 720 Query: 721 SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS 780 SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS Sbjct: 721 SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS 780 Query: 781 FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF 840 FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF Sbjct: 781 FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF 840 Query: 841 YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT 900 YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT Sbjct: 841 YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT 900 Query: 901 ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ 960 ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ Sbjct: 901 ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ 960 Query: 961 KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS 1020 KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS Sbjct: 961 KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS 1020 Query: 1021 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK 1080 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK Sbjct: 1021 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK 1080 Query: 1081 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH 1140 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH Sbjct: 1081 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH 1140 Query: 1141 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR 1200 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR Sbjct: 1141 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR 1200 Query: 1201 MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1241 MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV Sbjct: 1201 MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1241 >gi|157671951 solute carrier family 4, anion exchanger, member 3 isoform 1 [Homo sapiens] Length = 1232 Score = 1359 bits (3517), Expect = 0.0 Identities = 738/1239 (59%), Positives = 891/1239 (71%), Gaps = 67/1239 (5%) Query: 32 EQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPP 91 E+E+D+L +TL V RF +++ + + E+P RSY E DFE+HR +SHH HHPLS LPP Sbjct: 32 EEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPP 91 Query: 92 DARRRKTPQGPGRKPRRR-----PGASPTGETPTIEEG-------EEDEDEASEAEGARA 139 + R+ P R RR+ A P+ TP I+E EE+E+E E E Sbjct: 92 PHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAE 151 Query: 140 LTQPSPVSTPSSVQFFLQED-DSADRKAERTSPSSPAPL--PHQEATPRASKGAQAGTQV 196 +P P TP +F + D D + R + + P P PH + +P+ S + + Sbjct: 152 PVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPS---- 207 Query: 197 EEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVP 256 A A +A G RP + SY+L+ER GS G +VP Sbjct: 208 PRARASRLA-----------GEKSRPWSPSA----SYDLRERLCPGSALGNPGGPEQQVP 252 Query: 257 TDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTP-----R 311 TDE EAQ L +ADLD MKSHR ED PGVRRHLV+K ++ TQ GR G G P + Sbjct: 253 TDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGLAPILRRKK 309 Query: 312 ARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFR 371 + + +PHEVFVELNEL+LD++QEP WRETARWIKFEEDVEEETERWGKPHVASLSFR Sbjct: 310 KKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFR 369 Query: 372 SLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPS 431 SLLELRRT+AHGA LLDL+Q TLPG+AH VVE M++SDQI+ EDRA+VLR LLLKHSHP+ Sbjct: 370 SLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPN 429 Query: 432 DEKDFSF-PRNISAGSLGSLLGHHHGQGAESDPHVTEPLMG---GVPETRLEVERERELP 487 D+KD F PRN S+ S+ S+LG+HH + P P M G P + + + Sbjct: 430 DDKDSGFFPRNPSSSSMNSVLGNHHPTPSHG-PDGAVPTMADDLGEPAPLWPHDPDAKEK 488 Query: 488 PPAPPAGIT-RSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAV 546 P P G R KS LKLLEKIPE+AEATVVLVGCV FL +P AFVRL EAV L++V Sbjct: 489 PLHMPGGDGHRGKS---LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESV 545 Query: 547 LEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFL 606 LEVPVPVRFLF++LGPS + DYHE+GRSI+TLMSDK FHEAAY AD+R+DLL+AI+ FL Sbjct: 546 LEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFL 605 Query: 607 DCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL-LQMVE 665 D S+V+PPSEV+G +LLRSVA FQR++L+KR E+ + +A K L L++ Sbjct: 606 DGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGG 665 Query: 666 AAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAIT 725 + EDDPL RTG FGGL+RDVRRRYPHY SD RDAL QC+AAV+FIYFAALSPAIT Sbjct: 666 SEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAIT 725 Query: 726 FGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSN 785 FGGLLGEKT+ L+GVSELI+STA+ GV+F LLGAQPLLV+GFSGPLLVFEEAFF FC + Sbjct: 726 FGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQ 785 Query: 786 HLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVK 845 LEYL GRVW+G WLV L +VA EGSFLVR++S FTQEIFAFLISLIFIYETFYKL K Sbjct: 786 DLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYK 845 Query: 846 IFQEHPL---HGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTAL 902 +F EHPL + + +D G + PT GP + PR QPNTAL Sbjct: 846 VFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPS-----------PRNQPNTAL 894 Query: 903 LSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKL 962 LSL+LM GTFFIAFFLRKF+NSRF G+ RR+IGDFG+PI+IL+MVLVDYSI DTYTQKL Sbjct: 895 LSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKL 954 Query: 963 SVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKK 1022 +VP+G SVT+P+KR W I PLG PFP WMMVA+ +PA+LV ILIFMETQIT LI+S+K Sbjct: 955 TVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQK 1014 Query: 1023 ERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPK 1082 R L KGSGFHLDLLLI ++GG+C LFGLPWL AATVRSVTH NALTVM A+APGDKP+ Sbjct: 1015 ARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQ 1074 Query: 1083 IQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLL 1142 IQEV+EQRVTG+L+A LVGLSIV+G +LR+IPLAVLFGIFLYMGVTSL+GIQ +RL L+ Sbjct: 1075 IQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLI 1134 Query: 1143 LMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMV 1202 LMP KHHP+ YV KV+T RMHLFT +QL C+ALLW V STAASLAFPF+L+LTVPLR Sbjct: 1135 LMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHC 1194 Query: 1203 VLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1241 +L R+F DRE++ LD+ +AEP FDE +G DEYNE+ MPV Sbjct: 1195 LLPRLFQDRELQALDSEDAEPNFDE-DGQDEYNELHMPV 1232 >gi|157671953 solute carrier family 4, anion exchanger, member 3 isoform 2 [Homo sapiens] Length = 1259 Score = 1355 bits (3508), Expect = 0.0 Identities = 738/1247 (59%), Positives = 894/1247 (71%), Gaps = 56/1247 (4%) Query: 32 EQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPP 91 E+E+D+L +TL V RF +++ + + E+P RSY E DFE+HR +SHH HHPLS LPP Sbjct: 32 EEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPP 91 Query: 92 DARRRKTPQGPGRKPRRR-----PGASPTGETPTIEEG-------EEDEDEASEAEGARA 139 + R+ P R RR+ A P+ TP I+E EE+E+E E E Sbjct: 92 PHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAE 151 Query: 140 LTQPSPVSTPSSVQFFLQED-DSADRKAERTSPSSPAPL--PHQEATPRASKGAQA---- 192 +P P TP +F + D D + R + + P P PH + +P+ S + Sbjct: 152 PVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRD 211 Query: 193 --GTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGH--RSYNLQERRRIGSMTGAE 248 GT + + ++ AS K++P SY+L+ER GS G Sbjct: 212 GDGTTDLALSSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNP 271 Query: 249 QALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGP 308 +VPTDE EAQ L +ADLD MKSHR ED PGVRRHLV+K ++ TQ GR G G Sbjct: 272 GGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSR--TQGGR-GSPSGL 328 Query: 309 TP-----RARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKP 363 P + + + +PHEVFVELNEL+LD++QEP WRETARWIKFEEDVEEETERWGKP Sbjct: 329 APILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKP 388 Query: 364 HVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRAL 423 HVASLSFRSLLELRRT+AHGA LLDL+Q TLPG+AH VVE M++SDQI+ EDRA+VLR L Sbjct: 389 HVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTL 448 Query: 424 LLKHSHPSDEKDFSF-PRNISAGSLGSLLGHHHGQGAESDPHVTEPLMG---GVPETRLE 479 LLKHSHP+D+KD F PRN S+ S+ S+LG+HH + P P M G P Sbjct: 449 LLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHG-PDGAVPTMADDLGEPAPLWP 507 Query: 480 VERERELPPPAPPAGIT-RSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLR 538 + + + P P G R KS LKLLEKIPE+AEATVVLVGCV FL +P AFVRL Sbjct: 508 HDPDAKEKPLHMPGGDGHRGKS---LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLN 564 Query: 539 EAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDL 598 EAV L++VLEVPVPVRFLF++LGPS + DYHE+GRSI+TLMSDK FHEAAY AD+R+DL Sbjct: 565 EAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDL 624 Query: 599 LTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDK 658 L+AI+ FLD S+V+PPSEV+G +LLRSVA FQR++L+KR E+ + +A K Sbjct: 625 LSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGK 684 Query: 659 AL-LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYF 717 L L++ + EDDPL RTG FGGL+RDVRRRYPHY SD RDAL QC+AAV+FIYF Sbjct: 685 ELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYF 744 Query: 718 AALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEA 777 AALSPAITFGGLLGEKT+ L+GVSELI+STA+ GV+F LLGAQPLLV+GFSGPLLVFEEA Sbjct: 745 AALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEA 804 Query: 778 FFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIY 837 FF FC + LEYL GRVW+G WLV L +VA EGSFLVR++S FTQEIFAFLISLIFIY Sbjct: 805 FFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIY 864 Query: 838 ETFYKLVKIFQEHPL---HGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKP 894 ETFYKL K+F EHPL + + +D G + PT GP + P Sbjct: 865 ETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPS-----------P 913 Query: 895 RGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSI 954 R QPNTALLSL+LM GTFFIAFFLRKF+NSRF G+ RR+IGDFG+PI+IL+MVLVDYSI Sbjct: 914 RNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSI 973 Query: 955 EDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQI 1014 DTYTQKL+VP+G SVT+P+KR W I PLG PFP WMMVA+ +PA+LV ILIFMETQI Sbjct: 974 TDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQI 1033 Query: 1015 TTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKA 1074 T LI+S+K R L KGSGFHLDLLLI ++GG+C LFGLPWL AATVRSVTH NALTVM A Sbjct: 1034 TALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTA 1093 Query: 1075 VAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQ 1134 +APGDKP+IQEV+EQRVTG+L+A LVGLSIV+G +LR+IPLAVLFGIFLYMGVTSL+GIQ Sbjct: 1094 IAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQ 1153 Query: 1135 FYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILI 1194 +RL L+LMP KHHP+ YV KV+T RMHLFT +QL C+ALLW V STAASLAFPF+L+ Sbjct: 1154 LSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLL 1213 Query: 1195 LTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV 1241 LTVPLR +L R+F DRE++ LD+ +AEP FDE +G DEYNE+ MPV Sbjct: 1214 LTVPLRHCLLPRLFQDRELQALDSEDAEPNFDE-DGQDEYNELHMPV 1259 >gi|4507021 solute carrier family 4, anion exchanger, member 1 [Homo sapiens] Length = 911 Score = 1011 bits (2613), Expect = 0.0 Identities = 539/926 (58%), Positives = 682/926 (73%), Gaps = 74/926 (7%) Query: 321 HEVFVELNELLLD-KNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 379 H+V+VEL EL++D KNQE +W E ARW++ EE++ E WG+PH++ L+F SLLELRR Sbjct: 55 HKVYVELQELVMDEKNQELRWMEAARWVQLEENLGENGA-WGRPHLSHLTFWSLLELRRV 113 Query: 380 LAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFP 439 G VLLDL + +L GVA+Q++++ + DQI+ +DR +LRALLLKHSH Sbjct: 114 FTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSH---------- 163 Query: 440 RNISAGSLGSLLGHHHGQGAES-DPHVTEPLMG--GVPETRLEVERERELPPPAPPAGIT 496 AG L +L G S DP ++PL+ ET+L E+ P+GI Sbjct: 164 ----AGELEALGGVKPAVLTRSGDP--SQPLLPQHSSLETQLFCEQGDGGTEGHSPSGI- 216 Query: 497 RSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFL 556 LEKIP ++EAT+VLVG +FL +P + FVRL+EA EL+AV E+PVP+RFL Sbjct: 217 ----------LEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAV-ELPVPIRFL 265 Query: 557 FLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSE 616 F+LLGP + ++DY ++GR+ +TLMS++ F AY+A R +LL ++ FLDCS+VLPP++ Sbjct: 266 FVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTD 325 Query: 617 VQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLR 676 E+ L S+ QR++L++R + P D + + ++ G DDPL+ Sbjct: 326 APSEQALLSLVPVQRELLRRRYQSSPAKP-----------DSSFYKGLDLNGGP-DDPLQ 373 Query: 677 RTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQD 736 +TG+ FGGL+RD+RRRYP+YLSD DA PQ LAAVIFIYFAALSPAITFGGLLGEKT++ Sbjct: 374 QTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEKTRN 433 Query: 737 LIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWI 796 +GVSEL++STA+QG++F LLGAQPLLV+GFSGPLLVFEEAFFSFC +N LEY+VGRVWI Sbjct: 434 QMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWI 493 Query: 797 GFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCS 856 GFWL+ L +L+VA EGSFLVRF+SR+TQEIF+FLISLIFIYETF KL+KIFQ+HPL Sbjct: 494 GFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTY 553 Query: 857 ASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQ-PNTALLSLVLMAGTFFIA 915 N V KP+G PNTALLSLVLMAGTFF A Sbjct: 554 NYNVLMVP----------------------------KPQGPLPNTALLSLVLMAGTFFFA 585 Query: 916 FFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEK 975 LRKFKNS +FPG++RRVIGDFGVPI+ILIMVLVD+ I+DTYTQKLSVP GF V+ Sbjct: 586 MMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSA 645 Query: 976 RGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLD 1035 RGWVI+PLG +S FP+WMM AS LPA+LVFILIF+E+QITTLI+SK ER + KGSGFHLD Sbjct: 646 RGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLD 705 Query: 1036 LLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLL 1095 LLL+V MGG+ ALFG+PWL+A TVRSVTHANALTVM KA PG +IQEVKEQR++GLL Sbjct: 706 LLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLL 765 Query: 1096 VALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYV 1155 VA+LVGLSI++ +L +IPLAVLFGIFLYMGVTSL+GIQ ++R+ LL PPK+HPDV YV Sbjct: 766 VAVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYV 825 Query: 1156 KKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKC 1215 K+V+T RMHLFT +Q++CLA+LW V ST ASLA PF+LILTVPLR V+L IF + E++C Sbjct: 826 KRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQC 885 Query: 1216 LDANEAEPVFDEREGVDEYNEMPMPV 1241 LDA++A+ FDE EG DEY+E+ MPV Sbjct: 886 LDADDAKATFDEEEGRDEYDEVAMPV 911 >gi|90403614 solute carrier family 4, sodium bicarbonate cotransporter, member 8 isoform a [Homo sapiens] Length = 1093 Score = 679 bits (1753), Expect = 0.0 Identities = 404/1037 (38%), Positives = 587/1037 (56%), Gaps = 90/1037 (8%) Query: 229 GHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDL---MKSHRFEDVPGVR 285 G SY + + G L +E+E + + +SHR G + Sbjct: 11 GVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHG-Q 69 Query: 286 RHLVRKNAKGSTQSGREGREP--GPTPRARPR--------APHKPHEVFVELNELLLDKN 335 +H R KG++Q G EG E TP R + H PHE+F EL+E+ + + Sbjct: 70 KHRRRGRGKGASQ-GEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEG 128 Query: 336 QEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLP 395 ++ +W+ETARW+KFEEDVE+ ERW KP+VA+LS SL ELR L +G VLLD+ ++ Sbjct: 129 EDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIE 188 Query: 396 GVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSF-PRNISAGSLGSLLGHH 454 ++ +++Q +S + R V ALL KH H +++K + P S +G Sbjct: 189 EISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGK----- 243 Query: 455 HGQGAESDPHVTEP-----LMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEK 509 +SDPH+ + VP T LEV+ P + SK +L ++K Sbjct: 244 ----KQSDPHLMDKHGQTVSPQSVPTTNLEVKNGVNCEHS--PVDL----SKVDLHFMKK 293 Query: 510 IPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDY 569 IP AEA+ VLVG V+ L RP +AFVRL AV L + EVP+P RFLF+LLGP Y Sbjct: 294 IPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQY 353 Query: 570 HEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHF 629 HEIGRS++T+M+D+ FH+ AY A ER+DLL I+ FLD VLPP E + + Sbjct: 354 HEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNV 413 Query: 630 QRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDV 689 Q +KR+ G +P G + E G L+RTGR FGGL+ D+ Sbjct: 414 PSQ--EKRKMPG--VPNGNVCHIEQ----------EPHGGHSGPELQRTGRLFGGLVLDI 459 Query: 690 RRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTAL 749 +R+ P Y SD+RDAL QCLA+ +F+Y A +SP ITFGGLLGE T+ I E + ++ Sbjct: 460 KRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASM 519 Query: 750 QGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVA 809 G+ + L Q L ++G +GP+LVFE+ F FC L YL R IG W FL +++VA Sbjct: 520 TGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVA 579 Query: 810 LEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASN---------- 859 + S LV +++RFT+E FA LI +IFIYE KL+ + + +P+H S + Sbjct: 580 TDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCT 639 Query: 860 -------------------SSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT 900 ++EV N+T + + G S G G P+ Sbjct: 640 LPENPNNHTLQYWKDHNIVTAEVHWA-NLTVSECQEMHGEFMGSACGHHGP----YTPDV 694 Query: 901 ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ 960 S +L TF ++ L+ FK SR+FP R+R ++ DF V + I MV++D+ I + Sbjct: 695 LFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLI-GVPSP 753 Query: 961 KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS 1020 KL VPS F T + RGW+INP+G P P W ++A+++PA+L ILIFM+ QIT +II+ Sbjct: 754 KLQVPSVFKPTR-DDRGWIINPIG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIIN 809 Query: 1021 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK 1080 +KE L+KG G+HLDLL++ M G+C++ GLPW AATV S+TH N+L + S+ APG++ Sbjct: 810 RKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQ 869 Query: 1081 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH 1140 PK ++EQRVTGL++ +L+G S+ + +L+ IP+ VL+G+FLYMGV+SL GIQF++RL Sbjct: 870 PKFLGIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLK 929 Query: 1141 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR 1200 L MP KH PD Y++ V ++HLFT +QL CL LLW + ++ A++ FP +++ V +R Sbjct: 930 LFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVR 989 Query: 1201 MVVLTRIFTDREMKCLD 1217 V+ F+ RE+ LD Sbjct: 990 K-VMDLCFSKRELSWLD 1005 >gi|90568034 solute carrier family 4, sodium bicarbonate cotransporter, member 8 isoform b [Homo sapiens] Length = 1044 Score = 679 bits (1753), Expect = 0.0 Identities = 404/1037 (38%), Positives = 587/1037 (56%), Gaps = 90/1037 (8%) Query: 229 GHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDL---MKSHRFEDVPGVR 285 G SY + + G L +E+E + + +SHR G + Sbjct: 11 GVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHG-Q 69 Query: 286 RHLVRKNAKGSTQSGREGREP--GPTPRARPR--------APHKPHEVFVELNELLLDKN 335 +H R KG++Q G EG E TP R + H PHE+F EL+E+ + + Sbjct: 70 KHRRRGRGKGASQ-GEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEG 128 Query: 336 QEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLP 395 ++ +W+ETARW+KFEEDVE+ ERW KP+VA+LS SL ELR L +G VLLD+ ++ Sbjct: 129 EDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIE 188 Query: 396 GVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSF-PRNISAGSLGSLLGHH 454 ++ +++Q +S + R V ALL KH H +++K + P S +G Sbjct: 189 EISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGK----- 243 Query: 455 HGQGAESDPHVTEP-----LMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEK 509 +SDPH+ + VP T LEV+ P + SK +L ++K Sbjct: 244 ----KQSDPHLMDKHGQTVSPQSVPTTNLEVKNGVNCEHS--PVDL----SKVDLHFMKK 293 Query: 510 IPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDY 569 IP AEA+ VLVG V+ L RP +AFVRL AV L + EVP+P RFLF+LLGP Y Sbjct: 294 IPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQY 353 Query: 570 HEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHF 629 HEIGRS++T+M+D+ FH+ AY A ER+DLL I+ FLD VLPP E + + Sbjct: 354 HEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNV 413 Query: 630 QRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDV 689 Q +KR+ G +P G + E G L+RTGR FGGL+ D+ Sbjct: 414 PSQ--EKRKMPG--VPNGNVCHIEQ----------EPHGGHSGPELQRTGRLFGGLVLDI 459 Query: 690 RRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTAL 749 +R+ P Y SD+RDAL QCLA+ +F+Y A +SP ITFGGLLGE T+ I E + ++ Sbjct: 460 KRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASM 519 Query: 750 QGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVA 809 G+ + L Q L ++G +GP+LVFE+ F FC L YL R IG W FL +++VA Sbjct: 520 TGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVA 579 Query: 810 LEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASN---------- 859 + S LV +++RFT+E FA LI +IFIYE KL+ + + +P+H S + Sbjct: 580 TDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCT 639 Query: 860 -------------------SSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT 900 ++EV N+T + + G S G G P+ Sbjct: 640 LPENPNNHTLQYWKDHNIVTAEVHWA-NLTVSECQEMHGEFMGSACGHHGP----YTPDV 694 Query: 901 ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ 960 S +L TF ++ L+ FK SR+FP R+R ++ DF V + I MV++D+ I + Sbjct: 695 LFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLI-GVPSP 753 Query: 961 KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS 1020 KL VPS F T + RGW+INP+G P P W ++A+++PA+L ILIFM+ QIT +II+ Sbjct: 754 KLQVPSVFKPTR-DDRGWIINPIG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIIN 809 Query: 1021 KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK 1080 +KE L+KG G+HLDLL++ M G+C++ GLPW AATV S+TH N+L + S+ APG++ Sbjct: 810 RKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQ 869 Query: 1081 PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH 1140 PK ++EQRVTGL++ +L+G S+ + +L+ IP+ VL+G+FLYMGV+SL GIQF++RL Sbjct: 870 PKFLGIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLK 929 Query: 1141 LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR 1200 L MP KH PD Y++ V ++HLFT +QL CL LLW + ++ A++ FP +++ V +R Sbjct: 930 LFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVR 989 Query: 1201 MVVLTRIFTDREMKCLD 1217 V+ F+ RE+ LD Sbjct: 990 K-VMDLCFSKRELSWLD 1005 >gi|155722998 solute carrier family 4, sodium bicarbonate transporter-like, member 10 [Homo sapiens] Length = 1088 Score = 673 bits (1737), Expect = 0.0 Identities = 390/1003 (38%), Positives = 568/1003 (56%), Gaps = 71/1003 (7%) Query: 274 KSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGP--TPRARPR---------APHKPHE 322 KSHR G H RK + +GRE TP R + H PH+ Sbjct: 60 KSHRRHRHRG---HKHRKRDRERDSGLEDGRESPSFDTPSQRVQFILGTEDDDEEHIPHD 116 Query: 323 VFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAH 382 +F EL+E+ + ++ +WRETARW+KFEEDVE+ ERW KP+VA+LS SL ELR + + Sbjct: 117 LFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILN 176 Query: 383 GAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFS-FPRN 441 G VLLD+ TL +A V++Q V S Q+ + R V AL+ +H H + +K + P Sbjct: 177 GTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIV 236 Query: 442 ISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSKSK 501 S +G + + V+ E + +V RE T SK Sbjct: 237 RSFADIGKKQSEPNSMDKNAGQVVSPQSAPACVENKNDVSRENS----------TVDFSK 286 Query: 502 HELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLG 561 +L ++KIP AEA+ +LVG +EFL R +AFVRL AV L + EVP+P RFLF+LLG Sbjct: 287 VDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLG 346 Query: 562 PSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEE 621 P YHEIGRSI+TLM+D+ FH+ AY A +R DL++ I+ FLD VLPP E Sbjct: 347 PLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSI 406 Query: 622 LLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRP 681 + + Q +K +P G ++ E G L+RTGR Sbjct: 407 RIEPPKNVPSQEKRKIPA----VPNGTAAHGEA----------EPHGGHSGPELQRTGRI 452 Query: 682 FGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVS 741 FGGLI D++R+ P++ SDFRDA QCLA+ +F+Y A +SP ITFGGLLGE T+ I Sbjct: 453 FGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAI 512 Query: 742 ELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLV 801 E + ++ G+ + L G QPL ++G +GP+LVFE+ F FC L YL R IG W Sbjct: 513 ESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTA 572 Query: 802 FLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPL--------- 852 L +++VA + S LV +++RFT+E FA LI +IFIYE KL ++ + +P+ Sbjct: 573 TLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDLELL 632 Query: 853 --HGCSASNSSEVDGGENMTWAGARPTLG---------PGNRSLAGQ-----SGQGKPRG 896 + C+ G W + + +SL G+ G P Sbjct: 633 TQYSCNCVEPHNPSNGTLKEWRESNISASDIIWENLTVSECKSLHGEYVGRACGHDHPY- 691 Query: 897 QPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIED 956 P+ S++L T ++ L++FK SR+FP ++R ++ DF V + IL MVL+DY+I Sbjct: 692 VPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAI-G 750 Query: 957 TYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITT 1016 + KL VPS F T + RGW + PLG P P W ++A+++PA+L ILIFM+ QIT Sbjct: 751 IPSPKLQVPSVFKPTR-DDRGWFVTPLG---PNPWWTVIAAIIPALLCTILIFMDQQITA 806 Query: 1017 LIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVA 1076 +II++KE L+KG G+HLDLL++ M G+C++ GLPW AATV S+TH N+L + S+ A Sbjct: 807 VIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSA 866 Query: 1077 PGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFY 1136 PG++PK ++EQRVTGL++ +L+G S+ + +L+ IP+ VL+G+FLYMG +SL GIQF+ Sbjct: 867 PGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFF 926 Query: 1137 ERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILT 1196 +R+ L MP KH PD Y++ V ++HLFT +Q+ CL LLW + + A++ FP +++ Sbjct: 927 DRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSRAAIVFPMMVLAL 986 Query: 1197 VPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPM 1239 V +R ++ +FT RE+ LD E + E ++ E M Sbjct: 987 VFVRK-LMDLLFTKRELSWLDDLMPESKKKKLEDAEKEEEQSM 1028 >gi|197927160 solute carrier family 4, sodium bicarbonate cotransporter, member 4 isoform 3 [Homo sapiens] Length = 1094 Score = 658 bits (1697), Expect = 0.0 Identities = 376/945 (39%), Positives = 552/945 (58%), Gaps = 63/945 (6%) Query: 320 PHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 379 P ++F EL+ELL QE +W+ETARWIKFEE VE+ ERW KPHVA+LS SL ELR Sbjct: 105 PPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTC 164 Query: 380 LAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFP 439 + G+++LD + +LP + +V+ + + +K E + V LL KH H + + + Sbjct: 165 MEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLR-- 222 Query: 440 RNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSK 499 S +G + ++P P M T + + P K Sbjct: 223 ---SLADIGKTVSS--ASRMFTNPDNGSPAMTHRNLTSSSLNDISDKP----------EK 267 Query: 500 SKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLL 559 + + K ++K+P +AEA+ VLVG V+FL P +AFVRL++AV L A+ EVPVP RFLF+L Sbjct: 268 DQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFIL 327 Query: 560 LGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQG 619 LGP YHEIGR+I+TLMSD+ FH+ AY A +R DL+ I+ FLD +VLPP E Sbjct: 328 LGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDP 387 Query: 620 EELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTG 679 + +K G G P G + + L+RTG Sbjct: 388 AIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGG-------GGHGDCEELQRTG 440 Query: 680 RPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIG 739 R GGLI+D++R+ P + SDF DAL+ Q L+A++FIY A ++ AITFGGLLG+ T ++ G Sbjct: 441 RFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQG 500 Query: 740 VSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFW 799 V E + TA+ G +FCL QPL ++ +GP+LVFE F+F N+ +YL R+WIG W Sbjct: 501 VLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLW 560 Query: 800 LVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHG----- 854 FL L++VA + SFLV++ +RFT+E F+ LIS IFIY+ F K++K+ +P++ Sbjct: 561 SAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVG 620 Query: 855 --------CSASNSSEVDGGENMTWAGAR-PTLGPGNR--------SLAGQSGQGKPRGQ 897 C + + + + T A PT+ + + + K G Sbjct: 621 YNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGN 680 Query: 898 ---------PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMV 948 P+ L+S +L GT+ + L+KFK S +FP R++I DF + ++ILI Sbjct: 681 LVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFC 740 Query: 949 LVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILI 1008 ++D ++ T KL VPS F T+P RGW + P GE P W+ +A+ +PA+LV ILI Sbjct: 741 VID-ALVGVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN---PWWVCLAAAIPALLVTILI 795 Query: 1009 FMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANAL 1068 FM+ QIT +I+++KE L+KG+G+HLDL + + IC+L LPW AATV S+ H ++L Sbjct: 796 FMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSL 855 Query: 1069 TVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVT 1128 + ++ APG++PK V+EQRVTG LV +L GLS+ + +L+ IP+ VL+G+FLYMGV Sbjct: 856 KMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVA 915 Query: 1129 SLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLA 1188 SLNG+QF +RL LLLMP KH PD Y++ V R+HLFT LQ+LCLALLW + ST A++ Sbjct: 916 SLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAII 975 Query: 1189 FPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDE 1233 FP +++ V +R + +F+ ++ LD + P D+++ DE Sbjct: 976 FPVMILALVAVRK-GMDYLFSQHDLSFLD--DVIPEKDKKKKEDE 1017 >gi|4507025 solute carrier family 4, sodium bicarbonate cotransporter, member 4 isoform 2 [Homo sapiens] Length = 1035 Score = 658 bits (1697), Expect = 0.0 Identities = 376/945 (39%), Positives = 552/945 (58%), Gaps = 63/945 (6%) Query: 320 PHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 379 P ++F EL+ELL QE +W+ETARWIKFEE VE+ ERW KPHVA+LS SL ELR Sbjct: 61 PPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTC 120 Query: 380 LAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFP 439 + G+++LD + +LP + +V+ + + +K E + V LL KH H + + + Sbjct: 121 MEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLR-- 178 Query: 440 RNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSK 499 S +G + ++P P M T + + P K Sbjct: 179 ---SLADIGKTVSS--ASRMFTNPDNGSPAMTHRNLTSSSLNDISDKP----------EK 223 Query: 500 SKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLL 559 + + K ++K+P +AEA+ VLVG V+FL P +AFVRL++AV L A+ EVPVP RFLF+L Sbjct: 224 DQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFIL 283 Query: 560 LGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQG 619 LGP YHEIGR+I+TLMSD+ FH+ AY A +R DL+ I+ FLD +VLPP E Sbjct: 284 LGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDP 343 Query: 620 EELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTG 679 + +K G G P G + + L+RTG Sbjct: 344 AIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGG-------GGHGDCEELQRTG 396 Query: 680 RPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIG 739 R GGLI+D++R+ P + SDF DAL+ Q L+A++FIY A ++ AITFGGLLG+ T ++ G Sbjct: 397 RFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQG 456 Query: 740 VSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFW 799 V E + TA+ G +FCL QPL ++ +GP+LVFE F+F N+ +YL R+WIG W Sbjct: 457 VLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLW 516 Query: 800 LVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHG----- 854 FL L++VA + SFLV++ +RFT+E F+ LIS IFIY+ F K++K+ +P++ Sbjct: 517 SAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVG 576 Query: 855 --------CSASNSSEVDGGENMTWAGAR-PTLGPGNR--------SLAGQSGQGKPRGQ 897 C + + + + T A PT+ + + + K G Sbjct: 577 YNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGN 636 Query: 898 ---------PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMV 948 P+ L+S +L GT+ + L+KFK S +FP R++I DF + ++ILI Sbjct: 637 LVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFC 696 Query: 949 LVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILI 1008 ++D ++ T KL VPS F T+P RGW + P GE P W+ +A+ +PA+LV ILI Sbjct: 697 VID-ALVGVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN---PWWVCLAAAIPALLVTILI 751 Query: 1009 FMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANAL 1068 FM+ QIT +I+++KE L+KG+G+HLDL + + IC+L LPW AATV S+ H ++L Sbjct: 752 FMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSL 811 Query: 1069 TVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVT 1128 + ++ APG++PK V+EQRVTG LV +L GLS+ + +L+ IP+ VL+G+FLYMGV Sbjct: 812 KMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVA 871 Query: 1129 SLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLA 1188 SLNG+QF +RL LLLMP KH PD Y++ V R+HLFT LQ+LCLALLW + ST A++ Sbjct: 872 SLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAII 931 Query: 1189 FPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDE 1233 FP +++ V +R + +F+ ++ LD + P D+++ DE Sbjct: 932 FPVMILALVAVRK-GMDYLFSQHDLSFLD--DVIPEKDKKKKEDE 973 >gi|148596928 solute carrier family 4, sodium bicarbonate cotransporter, member 4 isoform 1 [Homo sapiens] Length = 1079 Score = 658 bits (1697), Expect = 0.0 Identities = 376/945 (39%), Positives = 552/945 (58%), Gaps = 63/945 (6%) Query: 320 PHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRT 379 P ++F EL+ELL QE +W+ETARWIKFEE VE+ ERW KPHVA+LS SL ELR Sbjct: 105 PPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTC 164 Query: 380 LAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFP 439 + G+++LD + +LP + +V+ + + +K E + V LL KH H + + + Sbjct: 165 MEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLR-- 222 Query: 440 RNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSK 499 S +G + ++P P M T + + P K Sbjct: 223 ---SLADIGKTVSS--ASRMFTNPDNGSPAMTHRNLTSSSLNDISDKP----------EK 267 Query: 500 SKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLL 559 + + K ++K+P +AEA+ VLVG V+FL P +AFVRL++AV L A+ EVPVP RFLF+L Sbjct: 268 DQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFIL 327 Query: 560 LGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQG 619 LGP YHEIGR+I+TLMSD+ FH+ AY A +R DL+ I+ FLD +VLPP E Sbjct: 328 LGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDP 387 Query: 620 EELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTG 679 + +K G G P G + + L+RTG Sbjct: 388 AIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGG-------GGHGDCEELQRTG 440 Query: 680 RPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIG 739 R GGLI+D++R+ P + SDF DAL+ Q L+A++FIY A ++ AITFGGLLG+ T ++ G Sbjct: 441 RFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQG 500 Query: 740 VSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFW 799 V E + TA+ G +FCL QPL ++ +GP+LVFE F+F N+ +YL R+WIG W Sbjct: 501 VLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLW 560 Query: 800 LVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHG----- 854 FL L++VA + SFLV++ +RFT+E F+ LIS IFIY+ F K++K+ +P++ Sbjct: 561 SAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVG 620 Query: 855 --------CSASNSSEVDGGENMTWAGAR-PTLGPGNR--------SLAGQSGQGKPRGQ 897 C + + + + T A PT+ + + + K G Sbjct: 621 YNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGN 680 Query: 898 ---------PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMV 948 P+ L+S +L GT+ + L+KFK S +FP R++I DF + ++ILI Sbjct: 681 LVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFC 740 Query: 949 LVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILI 1008 ++D ++ T KL VPS F T+P RGW + P GE P W+ +A+ +PA+LV ILI Sbjct: 741 VID-ALVGVDTPKLIVPSEFKPTSPN-RGWFVPPFGEN---PWWVCLAAAIPALLVTILI 795 Query: 1009 FMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANAL 1068 FM+ QIT +I+++KE L+KG+G+HLDL + + IC+L LPW AATV S+ H ++L Sbjct: 796 FMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSL 855 Query: 1069 TVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVT 1128 + ++ APG++PK V+EQRVTG LV +L GLS+ + +L+ IP+ VL+G+FLYMGV Sbjct: 856 KMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVA 915 Query: 1129 SLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLA 1188 SLNG+QF +RL LLLMP KH PD Y++ V R+HLFT LQ+LCLALLW + ST A++ Sbjct: 916 SLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAII 975 Query: 1189 FPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDE 1233 FP +++ V +R + +F+ ++ LD + P D+++ DE Sbjct: 976 FPVMILALVAVRK-GMDYLFSQHDLSFLD--DVIPEKDKKKKEDE 1017 >gi|19743827 sodium bicarbonate transporter 4 isoform c [Homo sapiens] Length = 1121 Score = 603 bits (1556), Expect = e-172 Identities = 369/987 (37%), Positives = 550/987 (55%), Gaps = 104/987 (10%) Query: 300 GREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETER 359 G E P PT +F E++ L D +Q +W+E+ARWIKFEE VEE ER Sbjct: 103 GEEDEAPNPT-------------LFTEMDTLQHDGDQM-EWKESARWIKFEEKVEEGGER 148 Query: 360 WGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANV 419 W KPHV++LS SL ELR L G VLLDLD +LP + V+E+ + ++ E R V Sbjct: 149 WSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERV 208 Query: 420 LRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDP------HVTEPLM--G 471 LL +H H + + P + S +G + + A S H TE L Sbjct: 209 SYVLLRRHRHQTKK-----PIHRSLADIGKSVSTTNRSPARSPGAGPSLHHSTEDLRMRQ 263 Query: 472 GVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPT 531 RL + R + +T + + + K ++KIP+++EA+ VLVG V+FL +P Sbjct: 264 SANYGRLCHAQSRSMND----ISLTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPF 319 Query: 532 MAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYL 591 +AFVRL ++ L V EVPVP RFLF+LLGPS Y+EIGR+I+TLM D F + AY Sbjct: 320 IAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYK 379 Query: 592 ADEREDLLTAINAFLDCSVVLPPSE----VQGEELLRSVAHFQRQMLKKREEQGRL---- 643 A REDL+ I+ FLD +VLPP E ++ E + + +R+ + E G++ Sbjct: 380 ARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSV 439 Query: 644 -----LPTGA----------------GLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPF 682 P G G S+ D + + G + L TGR F Sbjct: 440 GGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIG----EELIWTGRFF 495 Query: 683 GGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSE 742 GGL D++R+ P + SDF D Q ++A++FIY ++ AITFGGLLG+ T + GV E Sbjct: 496 GGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVME 555 Query: 743 LIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVF 802 + TA+ G +FCL QPL+++ +GP+L+FE+ F F N L+Y+ R+WIG Sbjct: 556 SFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAV 615 Query: 803 LALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSE 862 L++VA + SF++++++RFT+E F+ LIS IFIY+ K++ F+ +P++ N Sbjct: 616 QCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFIT 675 Query: 863 VDGGE-------NMTWAGARPTLGPGNR-----------------------SLAGQSGQG 892 E N T A L P S G+ Sbjct: 676 TYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLLSKKECLSYGGRLLGN 735 Query: 893 KPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVD- 951 + P+ AL+S +L GT+ + L+KFK SR+FP ++R ++ DF + +IL+ +D Sbjct: 736 SCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDA 795 Query: 952 -YSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFM 1010 + +E T KL VPS T P+ RGW + P G+ P W+ AS+LPA+LV ILIFM Sbjct: 796 CFGLE---TPKLHVPSVIKPTRPD-RGWFVAPFGKN---PWWVYPASILPALLVTILIFM 848 Query: 1011 ETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTV 1070 + QIT +I+++KE L+K +G+HLDL + + +C+ GLPW AATV S+ H ++L + Sbjct: 849 DQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKM 908 Query: 1071 MSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSL 1130 ++ APG++P+ V+EQRVTG++V +L G+S+ + +L+ IPL VL+G+FLYMGV SL Sbjct: 909 ETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMGVASL 968 Query: 1131 NGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFP 1190 NGIQF+ER L LMP KH PD +++ V R+HLFT +Q+LCLA+LW + ST A++ FP Sbjct: 969 NGIQFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFP 1028 Query: 1191 FILILTVPLRMVVLTRIFTDREMKCLD 1217 ++IL + + +L IF+ ++ +D Sbjct: 1029 -VMILGLIIVRRLLDFIFSQHDLAWID 1054 >gi|125987596 sodium bicarbonate transporter 4 isoform a [Homo sapiens] Length = 1137 Score = 593 bits (1529), Expect = e-169 Identities = 369/1003 (36%), Positives = 550/1003 (54%), Gaps = 120/1003 (11%) Query: 300 GREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETER 359 G E P PT +F E++ L D +Q +W+E+ARWIKFEE VEE ER Sbjct: 103 GEEDEAPNPT-------------LFTEMDTLQHDGDQM-EWKESARWIKFEEKVEEGGER 148 Query: 360 WGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANV 419 W KPHV++LS SL ELR L G VLLDLD +LP + V+E+ + ++ E R V Sbjct: 149 WSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERV 208 Query: 420 LRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDP------HVTEPLM--G 471 LL +H H + + P + S +G + + A S H TE L Sbjct: 209 SYVLLRRHRHQTKK-----PIHRSLADIGKSVSTTNRSPARSPGAGPSLHHSTEDLRMRQ 263 Query: 472 GVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPT 531 RL + R + +T + + + K ++KIP+++EA+ VLVG V+FL +P Sbjct: 264 SANYGRLCHAQSRSMND----ISLTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPF 319 Query: 532 MAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYL 591 +AFVRL ++ L V EVPVP RFLF+LLGPS Y+EIGR+I+TLM D F + AY Sbjct: 320 IAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYK 379 Query: 592 ADEREDLLTAINAFLDCSVVLPPSE----VQGEELLRSVAHFQRQMLKKREEQGRL---- 643 A REDL+ I+ FLD +VLPP E ++ E + + +R+ + E G++ Sbjct: 380 ARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSV 439 Query: 644 -----LPTGA----------------GLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPF 682 P G G S+ D + + G + L TGR F Sbjct: 440 GGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIG----EELIWTGRFF 495 Query: 683 GGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSE 742 GGL D++R+ P + SDF D Q ++A++FIY ++ AITFGGLLG+ T + GV E Sbjct: 496 GGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVME 555 Query: 743 LIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVF 802 + TA+ G +FCL QPL+++ +GP+L+FE+ F F N L+Y+ R+WIG Sbjct: 556 SFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAV 615 Query: 803 LALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSE 862 L++VA + SF++++++RFT+E F+ LIS IFIY+ K++ F+ +P++ N Sbjct: 616 QCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFIT 675 Query: 863 VDGGE-------NMTWAGARPTLGPGNR-----------------------SLAGQSGQG 892 E N T A L P S G+ Sbjct: 676 TYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLLSKKECLSYGGRLLGN 735 Query: 893 KPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVD- 951 + P+ AL+S +L GT+ + L+KFK SR+FP ++R ++ DF + +IL+ +D Sbjct: 736 SCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDA 795 Query: 952 -YSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFM 1010 + +E T KL VPS T P+ RGW + P G+ P W+ AS+LPA+LV ILIFM Sbjct: 796 CFGLE---TPKLHVPSVIKPTRPD-RGWFVAPFGKN---PWWVYPASILPALLVTILIFM 848 Query: 1011 ETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTV 1070 + QIT +I+++KE L+K +G+HLDL + + +C+ GLPW AATV S+ H ++L + Sbjct: 849 DQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKM 908 Query: 1071 MSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSL 1130 ++ APG++P+ V+EQRVTG++V +L G+S+ + +L+ IPL VL+G+FLYMGV SL Sbjct: 909 ETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMGVASL 968 Query: 1131 NGIQ----------------FYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCL 1174 NGIQ F+ER L LMP KH PD +++ V R+HLFT +Q+LCL Sbjct: 969 NGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCL 1028 Query: 1175 ALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKCLD 1217 A+LW + ST A++ FP ++IL + + +L IF+ ++ +D Sbjct: 1029 AVLWILKSTVAAIIFP-VMILGLIIVRRLLDFIFSQHDLAWID 1070 >gi|151101449 solute carrier family 4, sodium bicarbonate cotransporter, member 9 [Homo sapiens] Length = 959 Score = 577 bits (1487), Expect = e-164 Identities = 375/968 (38%), Positives = 522/968 (53%), Gaps = 110/968 (11%) Query: 292 NAKGSTQSGREGREPGPTPRARPRAPH----------KPHEVFVELNELLLDKNQEPQWR 341 +A + SG P P P P K +F++LNELL Q +WR Sbjct: 15 SAPRNIPSGELDSNPDPGTGPSPDGPSDTESKELGVPKDPLLFIQLNELL-GWPQALEWR 73 Query: 342 ETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQV 401 ET RW+ FEE +E RW PHV +L+ SL +LR LA G VLLD Q+L + QV Sbjct: 74 ETGRWVLFEEKLEVAAGRWSAPHVPTLALPSLQKLRSLLAEGLVLLDCPAQSLLELVEQV 133 Query: 402 VEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAES 461 +S +++ + L+ALLL+ H+ Q Sbjct: 134 TRVESLSPELRGQ-----LQALLLQRPQ------------------------HYNQTTG- 163 Query: 462 DPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLV 521 T P G + E L R + ++ L+ +K+P AEA VL Sbjct: 164 ----TRPCWGSTHPRKASDNEEAPL----------REQCQNPLR--QKLPPGAEAGTVLA 207 Query: 522 GCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMS 581 G + FL++P AFVRLR V L ++ EV +P RF LLLGP YHE+GR+ + L+S Sbjct: 208 GELGFLAQPLGAFVRLRNPVVLGSLTEVSLPSRFFCLLLGPCMLGKGYHEMGRAAAVLLS 267 Query: 582 DKQFHEAAYLADEREDLLTAINAFLDCSVVLPP------SEVQGEELLRSVAHFQRQMLK 635 D QF + A DLL A++AFL+ VLPP + + + L S +R + Sbjct: 268 DPQFQWSVRRASNLHDLLAALDAFLEEVTVLPPGRWDPTARIPPPKCLPS--QHKRLPSQ 325 Query: 636 KREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPH 695 +RE +G +P SA+D+ A L+RTGR FGGLI+DVRR+ P Sbjct: 326 QREIRGPAVP-----RLTSAEDRH-----RHGPHAHSPELQRTGRLFGGLIQDVRRKVPW 375 Query: 696 YLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFC 755 Y SDF DAL QC +AV++IY A ++ AITFGGLLG+ T GV E + TA+ G FC Sbjct: 376 YPSDFLDALHLQCFSAVLYIYLATVTNAITFGGLLGDATDGAQGVLESFLGTAVAGAAFC 435 Query: 756 LLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFL 815 L+ QPL ++ +GP+LVFE FSF L+YL R+W+G W+ L++VA E S L Sbjct: 436 LMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLVLVATEASVL 495 Query: 816 VRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPL-------HGCSASNSSEVDGGEN 868 VR+ +RFT+E F LISLIFIY+ K++ + +P+ +GC GG Sbjct: 496 VRYFTRFTEEGFCALISLIFIYDAVGKMLNLTHTYPIQKPGSSAYGCLCQYPGP--GGNE 553 Query: 869 MTWAGARPT---------LGPGNRSL-----AGQSGQGKPRGQ-----PNTALLSLVLMA 909 W RP LG N SL + G G PRG P+ A SL+L Sbjct: 554 SQWIRTRPKDRDDIVSMDLGLINASLLPPPECTRQG-GHPRGPGCHTVPDIAFFSLLLFL 612 Query: 910 GTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFS 969 +FF A L+ K SRFFP +R+ + DF +AIL+ +D + T KL VP F Sbjct: 613 TSFFFAMALKCVKTSRFFPSVVRKGLSDFSSVLAILLGCGLDAFL-GLATPKLMVPREFK 671 Query: 970 VTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKG 1029 T P RGW+++P G P W VA+ LPA+L+ ILIFM+ QIT +I+++ E LQKG Sbjct: 672 PTLPG-RGWLVSPFGAN---PWWWSVAAALPALLLSILIFMDQQITAVILNRMEYRLQKG 727 Query: 1030 SGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQ 1089 +GFHLDL + + + + GLPW +ATV S+ H ++L S+A APG++P ++EQ Sbjct: 728 AGFHLDLFCVAVLMLLTSALGLPWYVSATVISLAHMDSLRRESRACAPGERPNFLGIREQ 787 Query: 1090 RVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHH 1149 R+TGL+V +L G SI + +L+ IP+ VL+GIFLYMGV +L+ IQF R+ LLLMP KH Sbjct: 788 RLTGLVVFILTGASIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFTNRVKLLLMPAKHQ 847 Query: 1150 PDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFT 1209 PD+ ++ V R+HLFTA+QL CL LLW + ST A++ FP +L+ V +R L R+F+ Sbjct: 848 PDLLLLRHVPLTRVHLFTAIQLACLGLLWIIKSTPAAIIFPLMLLGLVGVRK-ALERVFS 906 Query: 1210 DREMKCLD 1217 +E+ LD Sbjct: 907 PQELLWLD 914 >gi|134288865 solute carrier family 4, sodium bicarbonate cotransporter, member 7 [Homo sapiens] Length = 1214 Score = 568 bits (1463), Expect = e-161 Identities = 317/743 (42%), Positives = 447/743 (60%), Gaps = 44/743 (5%) Query: 500 SKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLL 559 SK ++ + KIP AEA+ VLVG V+FL RP +AFVRL AV L + EVPVP RFLFLL Sbjct: 412 SKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLL 471 Query: 560 LGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQG 619 LGP+ YHEIGRSI+TLM+D+ FH+ AY A +R DLL+ I+ FLD VLPP E Sbjct: 472 LGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDP 531 Query: 620 EELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTG 679 + Q +K G PK A A L+RTG Sbjct: 532 SIRIEPPKSVPSQEKRKIPVFHNGSTPTLGETPKEAAHHA------------GPELQRTG 579 Query: 680 RPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIG 739 R FGGLI D++R+ P +LSDF+DAL QCLA+++F+Y A +SP ITFGGLLGE T+ I Sbjct: 580 RLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRIS 639 Query: 740 VSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFW 799 E + +L G+ + L QPL ++G +GP+LVFE+ + FC L YL R IG W Sbjct: 640 AIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLW 699 Query: 800 LVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKI-----FQEH---- 850 FL +++VA + S LV +++RFT+E FA LI +IFIYE KL + F H Sbjct: 700 TSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLD 759 Query: 851 --------------PLHGCSASNSSEVDGGENMTWAGARPTLGPGNRS--LAGQSGQGKP 894 P + A + N++W + R L G P Sbjct: 760 KLTSYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGP 819 Query: 895 RGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSI 954 P+ ++L TFF++ FL++FK R+FP ++R I DF V + I+IMV +DY + Sbjct: 820 Y-IPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLV 878 Query: 955 EDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQI 1014 + KL VP F T PE RGW+I+PLG+ P W ++ + +PA+L ILIFM+ QI Sbjct: 879 -GVPSPKLHVPEKFEPTHPE-RGWIISPLGDN---PWWTLLIAAIPALLCTILIFMDQQI 933 Query: 1015 TTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKA 1074 T +II++KE L+KG+G+HLDLL++ M G+C++ GLPW AATV S++H N+L V S+ Sbjct: 934 TAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESEC 993 Query: 1075 VAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQ 1134 APG++PK ++EQRVTGL++ +L+GLS+ + +L+ IP+ VL+G+FLYMGV+SL GIQ Sbjct: 994 SAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQ 1053 Query: 1135 FYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILI 1194 ++R+ L MP KH PD+ Y++ V ++H+FT +QL CL LLW + +AA++ FP +++ Sbjct: 1054 LFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVL 1113 Query: 1195 LTVPLRMVVLTRIFTDREMKCLD 1217 V +R ++ FT RE+ LD Sbjct: 1114 ALVFVRK-LMDLCFTKRELSWLD 1135 Score = 122 bits (307), Expect = 2e-27 Identities = 73/200 (36%), Positives = 108/200 (54%), Gaps = 18/200 (9%) Query: 287 HLVRKNAKGSTQSGREGREPGPTPRARPR---------APHKPHEVFVELNELLLDKNQE 337 H RK+ + + GRE TP R + H PH++F E++EL +E Sbjct: 68 HRRRKDKESDKEDGRESPSYD-TPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEE 126 Query: 338 PQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGV 397 +W+ETARW+KFEEDVE+ +RW KP+VA+LS SL ELR + +G V+LD+ TL + Sbjct: 127 YEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEI 186 Query: 398 AHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQ 457 A V++ M+ S Q+ R NV ALL +H H ++++ F I + +G H Sbjct: 187 ADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKR---FTSRIPLVRSFADIGKKH-- 241 Query: 458 GAESDPHVTEPLMGGVPETR 477 SDPH+ E G+ +R Sbjct: 242 ---SDPHLLERNGEGLSASR 258 >gi|14042960 solute carrier family 4 member 11 [Homo sapiens] Length = 891 Score = 251 bits (640), Expect = 4e-66 Identities = 205/710 (28%), Positives = 323/710 (45%), Gaps = 108/710 (15%) Query: 553 VRFLFLLLGPSS--ANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSV 610 VRF+ L+L P + E+ R+ +T+ SD F + E+ A+ Sbjct: 247 VRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEAL-------- 298 Query: 611 VLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAA 670 V +LL V+H + +E LP EP +D Sbjct: 299 ------VHQRQLLTMVSHGPVAP-RTKERSTVSLPAHRHPEPPKCKDFV----------- 340 Query: 671 EDDPLRRTGRPFG-GLIRDVRRRYPHYLSDFRDALDPQ------CLAAVIFIYFAALSPA 723 PFG G+ D+ RR+P Y DF D + + + +F+YFA L P Sbjct: 341 ----------PFGKGIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPT 390 Query: 724 ITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCS 783 I FG L E T I V + I ++ G+++ L QPL+++ + PL ++ + C Sbjct: 391 IAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICD 450 Query: 784 SNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKL 843 L++ W G W F L S ++ R T+EI A IS+ F+ + Sbjct: 451 DYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKGT 510 Query: 844 VKIFQEH------------------PLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSL 885 VKIF ++ L G AS ++ + N ++ A PT P Sbjct: 511 VKIFWKYYYGHYLDDYHTKRTSSLVSLSGLGASLNASLHTALNASFL-ASPTELPS---- 565 Query: 886 AGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAIL 945 A SGQ TA+LSL++M GT ++ + L +FK S + +R ++ D +PIA+L Sbjct: 566 ATHSGQA-------TAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVL 618 Query: 946 IMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAI--- 1002 L+ S E + NP +SPF + + + L A+ Sbjct: 619 AFSLI---------------SSHGFREIEMSKFRYNP--SESPFAMAQIQSLSLRAVSGA 661 Query: 1003 -----LVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAA 1057 L+ +L F+E + +++ E L KG+ +H DLLL+ + +LFGLPW+ AA Sbjct: 662 MGLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAA 721 Query: 1058 TVRSVTHANALTVMSKAVAPGD-KPKIQEVKEQRVTGLLVALLVGLSIVIGDL-LRQIPL 1115 S H AL ++ + V G I VKE R+T L ++LVGLS+++ + L+ IP Sbjct: 722 YPHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPK 781 Query: 1116 AVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLA 1175 VL+G+FLY+ +TSL+G Q +R+ LLL +P Y+++V ++H FT LQ+L L Sbjct: 782 PVLYGLFLYIALTSLDGNQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLL 841 Query: 1176 LLWAVMSTA---ASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEAE 1222 LL A ++ + FP I+I +P+R ++L RI E K LD +AE Sbjct: 842 LLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRII---EAKYLDVMDAE 888 >gi|61742808 hypothetical protein LOC283638 isoform 2 [Homo sapiens] Length = 1484 Score = 45.8 bits (107), Expect = 3e-04 Identities = 93/376 (24%), Positives = 138/376 (36%), Gaps = 87/376 (23%) Query: 2 SSAPRRPAKGADSFCTPEP----ESLGPGTPGFP-----------EQEEDELHRTLG--- 43 S+ R K S TP+P + + P P EQ + H LG Sbjct: 890 STVSLRSGKSGPSPTTPQPLRAQKEMSPSPPAAQDPGGTALVSAREQSSERQHHPLGPTD 949 Query: 44 VERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPD---ARRRKTPQ 100 + R E + + A RG R G D+ + P+ HLP A +TP+ Sbjct: 950 MGRGEPVRRSAIRRGH----RPRGSLDWPSEERG------PVLAHLPSSDVMASNHETPE 999 Query: 101 --GPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFF--- 155 G GR RR A+P +P E E+ AS +G +ALT+ + +STP + Sbjct: 1000 ATGAGRLGSRRKPAAPP-PSPAARE-EQSRSSASSQKGPQALTRSNSLSTPRPTRASRLR 1057 Query: 156 -LQEDDSADRKA---ERTSPSSPAPL--PHQE-----------ATPRASKGAQAGTQVEE 198 + D++D +A ER S +P P+ P E A PR G+ GT E Sbjct: 1058 RARLGDASDTEAADGERGSLGNPEPVGRPAAEQAKKLSRLDILAMPRKRAGSFTGTSDPE 1117 Query: 199 AE----------------------AEAVAVASGTAGGDDGGASGRPLPKAQPGHRSY-NL 235 A AEA AV+ A +P +A+ G Y + Sbjct: 1118 AAPARTSFSGRSVELCCASRKPTMAEARAVSRKAANTATTTGPRQPFSRARSGSARYTST 1177 Query: 236 QERRRIGSMTGA-EQALLPRVPTDEIE--------AQTLATADLDLMKSHRFEDVPGVRR 286 + R GS + A +A PR D+ E QT A++ + +DV + + Sbjct: 1178 TQTPRAGSSSRARSRAPGPRDTDDDEEEPDPYGFIVQTAEIAEIARLSQTLVKDVAILAQ 1237 Query: 287 HLVRKNAKGSTQSGRE 302 + G T E Sbjct: 1238 EIHDVAGDGDTLGSSE 1253 Score = 39.3 bits (90), Expect = 0.024 Identities = 42/153 (27%), Positives = 59/153 (38%), Gaps = 36/153 (23%) Query: 5 PRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFE--EILQEAGSRGGEEP 62 P+ P++ ADS PES PG PE + ++ R G E + + +GS GG P Sbjct: 632 PQLPSERADS--PAGPESSRRSGPGPPELDSEQPSRLFGQEELDPDSLSDASGSDGGRGP 689 Query: 63 GRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETP-TI 121 E E P D+RRR +GP RR +P TP + Sbjct: 690 -----EPGVE-----------------PQDSRRRSPQEGPTWSRGRRSPRAPGEPTPASF 727 Query: 122 EEGEEDEDEA---------SEAEGARALTQPSP 145 G+++ D + EG QPSP Sbjct: 728 FIGDQNGDAVLSRKPLAAPGDGEGLGQTAQPSP 760 >gi|163644261 hypothetical protein LOC283638 isoform 1 [Homo sapiens] Length = 1554 Score = 45.8 bits (107), Expect = 3e-04 Identities = 93/376 (24%), Positives = 138/376 (36%), Gaps = 87/376 (23%) Query: 2 SSAPRRPAKGADSFCTPEP----ESLGPGTPGFP-----------EQEEDELHRTLG--- 43 S+ R K S TP+P + + P P EQ + H LG Sbjct: 960 STVSLRSGKSGPSPTTPQPLRAQKEMSPSPPAAQDPGGTALVSAREQSSERQHHPLGPTD 1019 Query: 44 VERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPD---ARRRKTPQ 100 + R E + + A RG R G D+ + P+ HLP A +TP+ Sbjct: 1020 MGRGEPVRRSAIRRGH----RPRGSLDWPSEERG------PVLAHLPSSDVMASNHETPE 1069 Query: 101 --GPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFF--- 155 G GR RR A+P +P E E+ AS +G +ALT+ + +STP + Sbjct: 1070 ATGAGRLGSRRKPAAPP-PSPAARE-EQSRSSASSQKGPQALTRSNSLSTPRPTRASRLR 1127 Query: 156 -LQEDDSADRKA---ERTSPSSPAPL--PHQE-----------ATPRASKGAQAGTQVEE 198 + D++D +A ER S +P P+ P E A PR G+ GT E Sbjct: 1128 RARLGDASDTEAADGERGSLGNPEPVGRPAAEQAKKLSRLDILAMPRKRAGSFTGTSDPE 1187 Query: 199 AE----------------------AEAVAVASGTAGGDDGGASGRPLPKAQPGHRSY-NL 235 A AEA AV+ A +P +A+ G Y + Sbjct: 1188 AAPARTSFSGRSVELCCASRKPTMAEARAVSRKAANTATTTGPRQPFSRARSGSARYTST 1247 Query: 236 QERRRIGSMTGA-EQALLPRVPTDEIE--------AQTLATADLDLMKSHRFEDVPGVRR 286 + R GS + A +A PR D+ E QT A++ + +DV + + Sbjct: 1248 TQTPRAGSSSRARSRAPGPRDTDDDEEEPDPYGFIVQTAEIAEIARLSQTLVKDVAILAQ 1307 Query: 287 HLVRKNAKGSTQSGRE 302 + G T E Sbjct: 1308 EIHDVAGDGDTLGSSE 1323 Score = 39.3 bits (90), Expect = 0.024 Identities = 42/153 (27%), Positives = 59/153 (38%), Gaps = 36/153 (23%) Query: 5 PRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFE--EILQEAGSRGGEEP 62 P+ P++ ADS PES PG PE + ++ R G E + + +GS GG P Sbjct: 702 PQLPSERADS--PAGPESSRRSGPGPPELDSEQPSRLFGQEELDPDSLSDASGSDGGRGP 759 Query: 63 GRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETP-TI 121 E E P D+RRR +GP RR +P TP + Sbjct: 760 -----EPGVE-----------------PQDSRRRSPQEGPTWSRGRRSPRAPGEPTPASF 797 Query: 122 EEGEEDEDEA---------SEAEGARALTQPSP 145 G+++ D + EG QPSP Sbjct: 798 FIGDQNGDAVLSRKPLAAPGDGEGLGQTAQPSP 830 >gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] Length = 904 Score = 45.4 bits (106), Expect = 3e-04 Identities = 70/320 (21%), Positives = 103/320 (32%), Gaps = 32/320 (10%) Query: 18 PEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQS 77 PEP+ P E+E+++ + S P R + R Sbjct: 254 PEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRS------RSR 307 Query: 78 SHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGA 137 S+ S P RRR P+ PR R SP +S + + Sbjct: 308 SYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRS 367 Query: 138 RALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVE 197 R+ + P T S + + SA R PS PA P ++ + Q Sbjct: 368 RSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPA------TPPPKTRHSPTPQQSN 421 Query: 198 EAEAEAVAVASGTAGG---DDGGASGRPLPKAQPGHRSYNLQERR--RIGSMTGAEQALL 252 V+V+ G G G R P P R L E + G M A+ Sbjct: 422 RTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQ 481 Query: 253 PR------VPTDEIEAQTLATADLDLMKSH-RFEDVPGVRRH--------LVRKNAKGST 297 R + + ++ D +SH + +V RRH RK K ++ Sbjct: 482 RRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETS 541 Query: 298 QSGREGREPGPTPRARPRAP 317 GR R P P P R R+P Sbjct: 542 PRGRRRRSPSPPPTRRRRSP 561 Score = 34.3 bits (77), Expect = 0.76 Identities = 53/272 (19%), Positives = 90/272 (33%), Gaps = 18/272 (6%) Query: 53 EAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGA 112 E G R P RS + +++S S PP RRR P + RR P Sbjct: 516 EVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTP 575 Query: 113 SPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPS 172 P TP+ + + PSP + R SPS Sbjct: 576 PPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTA-------SPPPPPKRRASPS 628 Query: 173 SP-------APLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPK 225 P +P P Q ++P +K + + + + ++ A P P+ Sbjct: 629 PPPKRRVSHSPPPKQRSSP-VTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPR 687 Query: 226 AQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVR 285 + S + RR G+ + ++ P T I + T + +K VR Sbjct: 688 PRAPQTSSSPPPVRR-GASSSPQRRQSPSPSTRPIR-RVSRTPEPKKIKKAASPSPQSVR 745 Query: 286 RHLVRKNAKGSTQSGREGREPGPTPRARPRAP 317 R ++ GS + + + P P + ++P Sbjct: 746 RVSSSRSVSGSPEPAAK-KPPAPPSPVQSQSP 776 >gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sapiens] Length = 2715 Score = 44.7 bits (104), Expect = 6e-04 Identities = 38/140 (27%), Positives = 53/140 (37%), Gaps = 27/140 (19%) Query: 18 PEPESLGPG------TPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDF 71 P PE LGP G + D LG E F+E + AG+ G G G+ Sbjct: 1968 PPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGP--GDSSE 2025 Query: 72 EYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEA 131 E +S +IH P++ PG P PGA + +++G + E Sbjct: 2026 EESSPTSRYIHFPVTV-----------VSAPGLAPSATPGAPRIEQLDGVDDGTDSE--- 2071 Query: 132 SEAEGARALTQPSPVSTPSS 151 A A+ QP TP S Sbjct: 2072 -----AEAVQQPRGQGTPPS 2086 >gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] Length = 1312 Score = 43.9 bits (102), Expect = 0.001 Identities = 66/288 (22%), Positives = 108/288 (37%), Gaps = 34/288 (11%) Query: 90 PPDARRRKTPQGPGRK--PRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVS 147 PP + P GP + P +RP G ++++ A A P+P + Sbjct: 549 PPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDPDPAIPAPTA 608 Query: 148 TPSSVQFFLQEDDSADRKAERTSPSSPAPL-PHQEATPRASKGAQAGTQVEEAEAEAVAV 206 TPS+ ++++ + SP+ PA + P EA P+ + + A A+ Sbjct: 609 TPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVP---------QRTSSIATAL 659 Query: 207 ASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLA 266 + AGG + R P++ + Y LQ R G+ P P + L Sbjct: 660 NTSGAGGSRPAQAVRARPRSNSAWQIY-LQRRAERGTPKPPGPPAQPPGPPNASSNPDLR 718 Query: 267 TADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREG--REPGPTPRARPRAPHKPHE-- 322 +D +S +P HL + GS + R G +P +P P KP + Sbjct: 719 RSDPGWERSDSV--LPASHGHLPQ---AGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHR 773 Query: 323 -------VFVELNELLLDKNQEP-----QWRETARWIKFEEDVEEETE 358 FV L E LD+ P + ++ ++ ED EEE E Sbjct: 774 SRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGE 821 >gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] Length = 1332 Score = 43.9 bits (102), Expect = 0.001 Identities = 68/297 (22%), Positives = 114/297 (38%), Gaps = 38/297 (12%) Query: 84 PLSTHLPPDARRRKTPQGPGR-----KPRRRPGASPTGETPTIEEGEEDEDEASEAEGAR 138 PLS PP R + +GP + + +P A+P + ++++ A A Sbjct: 561 PLS-QTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDP 619 Query: 139 ALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPL-PHQEATPRASKGAQAGTQVE 197 P+P +TPS+ ++++ + SP+ PA + P EA P+ + Sbjct: 620 DPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVP---------Q 670 Query: 198 EAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPT 257 + A A+ + AGG + R P++ + Y LQ R G+ P P Sbjct: 671 RTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIY-LQRRAERGTPKPPGPPAQPPGPP 729 Query: 258 DEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREG--REPGPTPRARPR 315 + L +D +S +P HL + GS + R G +P +P P Sbjct: 730 NASSNPDLRRSDPGWERSDSV--LPASHGHLPQ---AGSLERNRVGVSSKPDSSPVLSPG 784 Query: 316 APHKPHE---------VFVELNELLLDKNQEP-----QWRETARWIKFEEDVEEETE 358 KP + FV L E LD+ P + ++ ++ ED EEE E Sbjct: 785 NKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGE 841 >gi|195963316 PWWP domain containing 2A isoform b [Homo sapiens] Length = 755 Score = 43.1 bits (100), Expect = 0.002 Identities = 45/170 (26%), Positives = 65/170 (38%), Gaps = 6/170 (3%) Query: 112 ASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVS-TPSSVQFFLQEDDSADRKAERTS 170 A+ T +P E E E G+ A T P PV+ T +SV E D + Sbjct: 8 AAATAASPGEGGAGEAEPEMEPIPGSEAGTDPLPVTATEASVPD--GETDGQQSAPQADE 65 Query: 171 PSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGH 230 P P P P R+ + G ++E E +V VA A GG P P A P Sbjct: 66 PPLPPPPPPPGELARSPEAV--GPELEAEEKLSVRVAESAAAAPQGGPELPPSP-ASPPE 122 Query: 231 RSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFED 280 + +ER AL+P D +Q + +++ + H ED Sbjct: 123 QPPAPEEREEPPLPQPVAPALVPPAGGDSTVSQLIPGSEVRVTLDHIIED 172 >gi|153791982 PWWP domain containing 2A isoform a [Homo sapiens] Length = 560 Score = 43.1 bits (100), Expect = 0.002 Identities = 45/170 (26%), Positives = 65/170 (38%), Gaps = 6/170 (3%) Query: 112 ASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVS-TPSSVQFFLQEDDSADRKAERTS 170 A+ T +P E E E G+ A T P PV+ T +SV E D + Sbjct: 8 AAATAASPGEGGAGEAEPEMEPIPGSEAGTDPLPVTATEASVPD--GETDGQQSAPQADE 65 Query: 171 PSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGH 230 P P P P R+ + G ++E E +V VA A GG P P A P Sbjct: 66 PPLPPPPPPPGELARSPEAV--GPELEAEEKLSVRVAESAAAAPQGGPELPPSP-ASPPE 122 Query: 231 RSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFED 280 + +ER AL+P D +Q + +++ + H ED Sbjct: 123 QPPAPEEREEPPLPQPVAPALVPPAGGDSTVSQLIPGSEVRVTLDHIIED 172 >gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens] Length = 1342 Score = 42.0 bits (97), Expect = 0.004 Identities = 52/199 (26%), Positives = 68/199 (34%), Gaps = 24/199 (12%) Query: 3 SAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEP 62 S G+ C P P SL P G E E H T +E + SR Sbjct: 1065 SCQESAVSGSSERC-PRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRS 1123 Query: 63 GRSYGEEDFEYHRQSSHHIHHPLST----------HLPPDARRRKTPQGPGRKPRRRPGA 112 R G+ + R S PLS ++ PD + TP R Sbjct: 1124 PRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSS------REGTL 1177 Query: 113 SPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQE------DDSADRKA 166 S G + + EEDEDE E R P PSS++ E D SA + Sbjct: 1178 SSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGS 1237 Query: 167 ERTSPSSPAP-LPHQEATP 184 ++ P P P +P TP Sbjct: 1238 TQSCPLHPVPIMPTAGTTP 1256 >gi|166795264 AE binding protein 2 isoform b [Homo sapiens] Length = 517 Score = 42.0 bits (97), Expect = 0.004 Identities = 38/161 (23%), Positives = 64/161 (39%), Gaps = 37/161 (22%) Query: 96 RKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEG------------------- 136 R +P PG PG++ G EE EE+E+E EAE Sbjct: 16 RLSPLPPGS-----PGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGG 70 Query: 137 --------ARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASK 188 A +++PSP S + + +E+D + + E +S +E++ + Sbjct: 71 GGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGG----GEEESSAESLV 126 Query: 189 GAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPG 229 G+ G+ +E + + AS ++ GD G G PK G Sbjct: 127 GSSGGSSSDETRSLSPGAAS-SSSGDGDGKEGLEEPKGPRG 166 >gi|166795262 AE binding protein 2 isoform a [Homo sapiens] Length = 503 Score = 42.0 bits (97), Expect = 0.004 Identities = 38/161 (23%), Positives = 64/161 (39%), Gaps = 37/161 (22%) Query: 96 RKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEG------------------- 136 R +P PG PG++ G EE EE+E+E EAE Sbjct: 16 RLSPLPPGS-----PGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGG 70 Query: 137 --------ARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASK 188 A +++PSP S + + +E+D + + E +S +E++ + Sbjct: 71 GGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGG----GEEESSAESLV 126 Query: 189 GAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPG 229 G+ G+ +E + + AS ++ GD G G PK G Sbjct: 127 GSSGGSSSDETRSLSPGAAS-SSSGDGDGKEGLEEPKGPRG 166 >gi|59806361 hypothetical protein LOC387104 [Homo sapiens] Length = 947 Score = 41.2 bits (95), Expect = 0.006 Identities = 62/290 (21%), Positives = 97/290 (33%), Gaps = 9/290 (3%) Query: 7 RPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSY 66 +P GA++ +LG PG PE+ EL L E G GGE G Sbjct: 119 QPVAGAEAAPAATLAALGGRRPGPPEEPPRELESVPSKLGEPPPLGEGGGGGGEGGGAGG 178 Query: 67 GEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEE 126 G + R+ P R ++ G P +S G+TP Sbjct: 179 GSGE----REGGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGTGSRNS 234 Query: 127 DEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRA 186 A G +QF L+++ +A A + ++P + Sbjct: 235 GSGVAGGGSGGGGSYWKEGCLQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVS 294 Query: 187 SKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTG 246 A T + + A A G +G ASG + A P + Q+ + M Sbjct: 295 GPPAVCETLAVASASPMAAAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQE 354 Query: 247 AEQALLPRVPTDEIEAQTLATADLDLMKSHRFED----VPGVRRHLVRKN 292 + L T + E L T ++D M+ FE+ + +R L R N Sbjct: 355 EMEKLREENETLKNEIDELRT-EMDEMRDTFFEEDACQLQEMRHELERAN 403 >gi|91208420 bassoon protein [Homo sapiens] Length = 3926 Score = 41.2 bits (95), Expect = 0.006 Identities = 80/340 (23%), Positives = 123/340 (36%), Gaps = 35/340 (10%) Query: 95 RRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQF 154 ++K PQG G+ G P +P + +AS A+ L P TPSSVQ Sbjct: 554 KQKGPQGLGQPS----GPLPAKASPLSTKASPLPSKASPQ--AKPLRASEPSKTPSSVQ- 606 Query: 155 FLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGD 214 ++ KAE P P P TP K + E A AV GG+ Sbjct: 607 --EKKTRVPTKAE----PMPKPPPETTPTPATPKVKSGVRRAEPATPVVKAVPEAPKGGE 660 Query: 215 DGGASGRPLPKAQPGHRS-YNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLA--TADLD 271 G+P +Q RS +L + + Q+ + V E+E A T Sbjct: 661 AEDLVGKPY--SQDASRSPQSLSDTGYSSDGISSSQSEITGVVQQEVEQLDSAGVTGPHP 718 Query: 272 LMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHKPHEVF---VELN 328 S + +R L + S +S G + RP + E F EL Sbjct: 719 PSPSEIHKVGSSMRPLLQAQGLAPSERSKPLSSGTGEEQKQRPHSLSITPEAFDSDEELE 778 Query: 329 ELLLDKNQEPQWRETARWIKFEEDVEEETERWGK----PHVASLSFRSLLEL-RRTLAHG 383 ++L + +WR + ++D E ++ +G +V S L L + A Sbjct: 779 DILEEDEDSAEWRRR----REQQDTAESSDDFGSQLRHDYVEDSSEGGLSPLPPQPPARA 834 Query: 384 AVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRAL 423 A L D D + Q++E D ++ +D A R L Sbjct: 835 AELTDED-----FMRRQILEMSAEEDNLEEDDTATSGRGL 869 Score = 40.0 bits (92), Expect = 0.014 Identities = 55/216 (25%), Positives = 75/216 (34%), Gaps = 12/216 (5%) Query: 44 VERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPG 103 V++ E L AG G P S E H+ S + L P R + G G Sbjct: 701 VQQEVEQLDSAGVTGPHPPSPS------EIHKVGSSMRPLLQAQGLAPSERSKPLSSGTG 754 Query: 104 RKPRRRPGA-SPTGETPTIEEGEED--EDEASEAEGARALTQPSPVSTPSSVQFFLQEDD 160 + ++RP + S T E +E ED E++ AE R Q + L+ D Sbjct: 755 EEQKQRPHSLSITPEAFDSDEELEDILEEDEDSAEWRRRREQQDTAESSDDFGSQLRHDY 814 Query: 161 SADRKAERTSPSSPAPLPHQ-EATPRASKGAQAGTQVEEAE--AEAVAVASGTAGGDDGG 217 D SP P P E T Q E + E SG G Sbjct: 815 VEDSSEGGLSPLPPQPPARAAELTDEDFMRRQILEMSAEEDNLEEDDTATSGRGLAKHGT 874 Query: 218 ASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLP 253 G P P+ +P L +RR + T + LLP Sbjct: 875 QKGGPRPRPEPSQEPAALPKRRLPHNATTGYEELLP 910 Score = 31.2 bits (69), Expect = 6.4 Identities = 31/134 (23%), Positives = 45/134 (33%), Gaps = 21/134 (15%) Query: 91 PDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEED---EDEASEAEGARALTQPSPVS 147 P ++ ++ P P P P G+ P E + + +AE ARA + P P Sbjct: 234 PRSKSQQQLHSPALSPAHSPAKQPLGK-PDQERSRGPGGPQPGSRQAETARATSVPGPAQ 292 Query: 148 TPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVA 207 +A + R SP P P A PR G + A AV Sbjct: 293 A------------AAPPEVGRVSPQPPQPTKPSTAEPRPPAG-----EAPAKSATAVPAG 335 Query: 208 SGTAGGDDGGASGR 221 G G +G+ Sbjct: 336 LGATEQTQEGLTGK 349 >gi|4502805 chromogranin A precursor [Homo sapiens] Length = 457 Score = 40.8 bits (94), Expect = 0.008 Identities = 57/267 (21%), Positives = 96/267 (35%), Gaps = 47/267 (17%) Query: 122 EEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQE 181 E E E+++S+AE A+ +PS V ++ A++ E T + P LP Sbjct: 103 ELSEVLENQSSQAELKEAVEEPSS----KDVMEKREDSKEAEKSGEATDGARPQALPEPM 158 Query: 182 ATPRASKGAQAGTQVEEAEAEAVAV-----------ASGTAGGDDGGASGRPLPK----- 225 +A QA + EE E EA A GD G S + + Sbjct: 159 QESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLS 218 Query: 226 AQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVR 285 A+PG ++ +E E+A+ E E T+ ++ H +R Sbjct: 219 AEPGWQAKREEEEEEEEEAEAGEEAV------PEEEGPTV------VLNPHPSLGYKEIR 266 Query: 286 RHLVRKNAKGSTQSGREGREPGPTPRARPRAPHK------------PHEVFVELNELLLD 333 + R A +G+ G E P + H P +F L+ Sbjct: 267 KGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELE 326 Query: 334 KNQE---PQWRETARWIKFEEDVEEET 357 + +E +W ++ RW K ++ +E T Sbjct: 327 QEEERLSKEWEDSKRWSKMDQLAKELT 353 Score = 37.7 bits (86), Expect = 0.069 Identities = 40/171 (23%), Positives = 65/171 (38%), Gaps = 5/171 (2%) Query: 49 EILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQG--PGRKP 106 E +QE+ + G + + GEE+ E ++ H L + P + +G G Sbjct: 156 EPMQESKAEGNNQ---APGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVD 212 Query: 107 RRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKA 166 R + ++ G EE EE+E+EA E A + V +E + ++ Sbjct: 213 REKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRS 272 Query: 167 ERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGG 217 E + +EA KG Q +Q +E E E V G G G Sbjct: 273 EALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSG 323 >gi|239754674 PREDICTED: hypothetical protein [Homo sapiens] Length = 480 Score = 40.8 bits (94), Expect = 0.008 Identities = 36/136 (26%), Positives = 54/136 (39%), Gaps = 7/136 (5%) Query: 118 TPTIEEGEEDEDEASEA----EGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSS 173 TP +EG S+ E A QP P + P+ V+ + + ++ R+ + Sbjct: 182 TPPRQEGSFGGRPKSQPPLPQETAAPAPQPGPTAPPARVREPGRAEGASREPRLRSRAAR 241 Query: 174 PAPLPHQEATPRASKGAQAGTQ---VEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGH 230 P P P A RAS+ AG E A A G GG + GA GR P ++ Sbjct: 242 PPPAPGPGALSRASRSRAAGRPGPGFHGGEKAAAPRAPGGGGGRNPGALGRAAPPSRARQ 301 Query: 231 RSYNLQERRRIGSMTG 246 ++ L +G G Sbjct: 302 DAWGLSGCATVGLRRG 317 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.137 0.403 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 51,374,365 Number of Sequences: 37866 Number of extensions: 2655172 Number of successful extensions: 16514 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 38 Number of HSP's successfully gapped in prelim test: 453 Number of HSP's that attempted gapping in prelim test: 14935 Number of HSP's gapped (non-prelim): 1780 length of query: 1241 length of database: 18,247,518 effective HSP length: 114 effective length of query: 1127 effective length of database: 13,930,794 effective search space: 15700004838 effective search space used: 15700004838 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.