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Search of human proteins with 155969695
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
(1125 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 2294 0.0
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 2262 0.0
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 1103 0.0
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 934 0.0
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 928 0.0
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 924 0.0
gi|148746189 multiple PDZ domain protein [Homo sapiens] 122 2e-27
gi|112382257 InaD-like [Homo sapiens] 114 7e-25
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 112 2e-24
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 107 8e-23
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 107 8e-23
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 105 3e-22
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 105 3e-22
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 105 3e-22
gi|45827729 scribble isoform b [Homo sapiens] 101 3e-21
gi|45827731 scribble isoform a [Homo sapiens] 101 3e-21
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 100 1e-20
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 96 1e-19
gi|156546890 WW and C2 domain containing 2 [Homo sapiens] 91 6e-18
gi|21361142 PDZ domain containing 1 [Homo sapiens] 87 9e-17
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 86 2e-16
gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens] 86 3e-16
gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens] 86 3e-16
gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens] 86 3e-16
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 82 4e-15
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 82 4e-15
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 81 5e-15
gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens] 79 2e-14
gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens] 79 2e-14
gi|87196343 PDZ domain containing 2 [Homo sapiens] 78 4e-14
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 2294 bits (5945), Expect = 0.0
Identities = 1125/1125 (100%), Positives = 1125/1125 (100%)
Query: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVV 60
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVV
Sbjct: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVV 60
Query: 61 SGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQ 120
SGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQ
Sbjct: 61 SGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQ 120
Query: 121 FQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLES 180
FQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLES
Sbjct: 121 FQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLES 180
Query: 181 GTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEE 240
GTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEE
Sbjct: 181 GTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEE 240
Query: 241 EDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWE 300
EDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWE
Sbjct: 241 EDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWE 300
Query: 301 MAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDH 360
MAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDH
Sbjct: 301 MAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDH 360
Query: 361 LNQKTQFENPVEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGF 420
LNQKTQFENPVEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGF
Sbjct: 361 LNQKTQFENPVEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGF 420
Query: 421 GFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLV 480
GFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLV
Sbjct: 421 GFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLV 480
Query: 481 PVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQ 540
PVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQ
Sbjct: 481 PVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQ 540
Query: 541 NGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQK 600
NGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQK
Sbjct: 541 NGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQK 600
Query: 601 VKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSP 660
VKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSP
Sbjct: 601 VKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSP 660
Query: 661 TKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPP 720
TKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPP
Sbjct: 661 TKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPP 720
Query: 721 NTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIP 780
NTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIP
Sbjct: 721 NTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIP 780
Query: 781 VKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEV 840
VKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEV
Sbjct: 781 VKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEV 840
Query: 841 PARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG 900
PARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG
Sbjct: 841 PARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG 900
Query: 901 DHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRP 960
DHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRP
Sbjct: 901 DHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRP 960
Query: 961 MGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCY 1020
MGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCY
Sbjct: 961 MGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCY 1020
Query: 1021 PVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT 1080
PVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT
Sbjct: 1021 PVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT 1080
Query: 1081 HTRAIELIQAGGNKVLLLLRPGTGLIPDHGLAPSGLCSYVKPEQH 1125
HTRAIELIQAGGNKVLLLLRPGTGLIPDHGLAPSGLCSYVKPEQH
Sbjct: 1081 HTRAIELIQAGGNKVLLLLRPGTGLIPDHGLAPSGLCSYVKPEQH 1125
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 2262 bits (5862), Expect = 0.0
Identities = 1110/1110 (100%), Positives = 1110/1110 (100%)
Query: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVV 60
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVV
Sbjct: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVV 60
Query: 61 SGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQ 120
SGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQ
Sbjct: 61 SGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQ 120
Query: 121 FQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLES 180
FQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLES
Sbjct: 121 FQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLES 180
Query: 181 GTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEE 240
GTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEE
Sbjct: 181 GTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEE 240
Query: 241 EDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWE 300
EDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWE
Sbjct: 241 EDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWE 300
Query: 301 MAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDH 360
MAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDH
Sbjct: 301 MAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDH 360
Query: 361 LNQKTQFENPVEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGF 420
LNQKTQFENPVEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGF
Sbjct: 361 LNQKTQFENPVEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGF 420
Query: 421 GFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLV 480
GFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLV
Sbjct: 421 GFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLV 480
Query: 481 PVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQ 540
PVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQ
Sbjct: 481 PVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQ 540
Query: 541 NGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQK 600
NGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQK
Sbjct: 541 NGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQK 600
Query: 601 VKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSP 660
VKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSP
Sbjct: 601 VKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSP 660
Query: 661 TKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPP 720
TKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPP
Sbjct: 661 TKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPP 720
Query: 721 NTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIP 780
NTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIP
Sbjct: 721 NTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIP 780
Query: 781 VKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEV 840
VKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEV
Sbjct: 781 VKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEV 840
Query: 841 PARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG 900
PARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG
Sbjct: 841 PARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG 900
Query: 901 DHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRP 960
DHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRP
Sbjct: 901 DHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRP 960
Query: 961 MGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCY 1020
MGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCY
Sbjct: 961 MGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCY 1020
Query: 1021 PVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT 1080
PVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT
Sbjct: 1021 PVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT 1080
Query: 1081 HTRAIELIQAGGNKVLLLLRPGTGLIPDHG 1110
HTRAIELIQAGGNKVLLLLRPGTGLIPDHG
Sbjct: 1081 HTRAIELIQAGGNKVLLLLRPGTGLIPDHG 1110
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 1103 bits (2853), Expect = 0.0
Identities = 618/1242 (49%), Positives = 802/1242 (64%), Gaps = 140/1242 (11%)
Query: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVV 60
MSK+LKKK HW SKV E + P G G E++GGAE G+FPYLG ++ G
Sbjct: 1 MSKSLKKKSHWTSKVHESVIG-RNPEGQLGFELKGGAENGQFPYLGEVKP----GKVAYE 55
Query: 61 SGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQ 120
SG ++LLEVN TPV+GLT RD LAVI+H ++P+RLK VK G +++KDLRHYL+L+
Sbjct: 56 SGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLR 115
Query: 121 FQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLES 180
FQKGS+DH+LQQ+IRDNLYLRT+PCTTR ++GEVPGVDY FI+VE F LE+SGALLES
Sbjct: 116 FQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLES 175
Query: 181 GTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEE 240
GTY+ N+YGTPKPPAEP+P + DQ+L AE +RKR SVS ME+ S P EE
Sbjct: 176 GTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKA-SIEPPEE 234
Query: 241 EDEDKEAINGSG------NAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRD----- 289
E+E++ +NG+G ++E+ ++ + +S M + P S + M D
Sbjct: 235 EEEERPVVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTK 294
Query: 290 ----ETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGW 345
E +PLP NWEMAYT+ G +YFIDHNTKTT+WLDPRL KKAK PE+C++ ELPYGW
Sbjct: 295 PEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGW 354
Query: 346 EKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQ---LGQVEIGSSKP-----DMEKSHF 397
EKI+DP YGTYYVDH+N++TQFENPV EAKRK Q + E+G +KP EK F
Sbjct: 355 EKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELG-TKPLQAPGFREKPLF 413
Query: 398 TRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVI 457
TRD SQLKG + +LKKS MGFGFTIIGGD PDEFLQVK+V+ DGPAAQDGK+ GDVI
Sbjct: 414 TRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVI 473
Query: 458 VDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPV---- 513
V IN CVLGHTHADVV++FQ VP+ Q VNL LCRGYPLP D EDP +V +
Sbjct: 474 VYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERP 533
Query: 514 ----INGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDG-LNG--PSDASEQRVSM 566
+NG+ + + + + ++ S H++ DG L+G P + VSM
Sbjct: 534 PPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSM 593
Query: 567 ASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQN 626
ASSG++Q EL+T+ ++KG +GFGF IADSPTGQ+VK ILD Q C GL +GD+I EI QN
Sbjct: 594 ASSGATQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQN 653
Query: 627 VQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLE-AINEP-I 684
VQNL+H +VV++LK P+G++ L+I RGG SP KT K D+ EN GS + +++ P I
Sbjct: 654 VQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAI 713
Query: 685 PQPMPFPPSIIRSGSP---------KLDPSEVYLKSKTLYEDK---PPNT---------- 722
PQ +PFPP++ RS P K DP E+Y KS+ +YE + PP T
Sbjct: 714 PQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPD 773
Query: 723 -KDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPV 781
K+LDV LR+ ESGFGFR+LGGD P Q I IGA+I +G+A++DGRL DEL+ +DGIPV
Sbjct: 774 YKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPV 833
Query: 782 KGKSHKQVLDLMTTAARNGHVLLTVRRKIFY-GEKQPEDDSSQAFISTQNGSPR------ 834
GK+H+ V+DLM AARNG V LTVRRK+ GE PE+ S +ST + SPR
Sbjct: 834 AGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATY 893
Query: 835 --LNRAEVPARPAPQEPY--------DVVLQRKENEGFGFVILTSKNKPPPG---VIPHK 881
N A + +P E + DVV+ RKENEGFGFVI++S N+P G +PHK
Sbjct: 894 TNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHK 953
Query: 882 IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHH 941
IGR+I+GSPADRC KLKVGD I AVNGQSI+ + H +IV+LIKDAG++VTL +I +EE +
Sbjct: 954 IGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELN 1013
Query: 942 GPPSGTNSARQSPALQHRPMGQS---------------------QANHIPGDRSALEGEI 980
P S +S +QSP Q P+ Q Q + G ++ E+
Sbjct: 1014 SPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEV 1073
Query: 981 --GKDVS--------TSYRHSWSDHK-----------------------HLAQPDTAVIS 1007
+DV T YR D++ PDT
Sbjct: 1074 KARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYP 1133
Query: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQ 1067
+ R Q+ + V++E+G +GFGFS+RGG+EY M L++LRLAEDGPAI++GR+ VGDQ
Sbjct: 1134 LSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQ 1193
Query: 1068 IVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDH 1109
I+EINGE T+ +TH RAIELI++GG +V LLL+ GTG +P++
Sbjct: 1194 IIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEY 1235
Score = 107 bits (267), Expect = 6e-23
Identities = 146/668 (21%), Positives = 246/668 (36%), Gaps = 135/668 (20%)
Query: 260 HSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTT 319
H+E D +K P ++T+ + + +T +P+ WE + + T
Sbjct: 659 HTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWE------------NQGSPQT 706
Query: 320 TWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQ 379
+ P + + P P E DP+ Y + + +E+ + R
Sbjct: 707 SLSAPAIPQNLPFPPALHRSSFPDSTEAF-DPRKPDPYELYEKSRAIYESRQQVPPRTS- 764
Query: 380 LGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNV 439
+ SS PD ++ + L++ GFGF I+GGD P + + + V
Sbjct: 765 ---FRMDSSGPDYKE--------------LDVHLRRMESGFGFRILGGDEPGQPILIGAV 807
Query: 440 LKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLT-----LCRGY 494
+ G A +DG++ PGD +V ++G V G TH V+ + N VNLT LC G
Sbjct: 808 IAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGE 867
Query: 495 PLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLN 554
P P++ P + + + T N P + G + H+L +
Sbjct: 868 PCPENGRSP-----GSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVV 922
Query: 555 GPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQ 614
+E + S ++PE + I P G I SP + C L+
Sbjct: 923 IHRKENEGFGFVIISSLNRPESGST--ITVPHKIGRIIDGSPADR----------CAKLK 970
Query: 615 KGDIIKEIYHQNVQNLTHLQVVEVLK---------------------------------Q 641
GD I + Q++ N+ H +V+++K Q
Sbjct: 971 VGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQ 1030
Query: 642 FPVGADVPLL----------ILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPF- 690
P+ PL I + PP P + + + + + + I QP PF
Sbjct: 1031 SPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQP-PFT 1089
Query: 691 ----PPSIIRS---GSPKLDPSEVYLKSKTL-YEDKPPNTK-----------DLDVF--- 728
PP R G + P Y + L Y P+T+ D D F
Sbjct: 1090 DYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVD 1149
Query: 729 LRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQ 788
+ K GFGF + GG +Y+ + G A ++GR+R D+++ I+G + +H +
Sbjct: 1150 MEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHAR 1209
Query: 789 VLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEV-------- 840
++L+ + R +LL K G+ PE D + S +P L V
Sbjct: 1210 AIELIKSGGRRVRLLL----KRGTGQ-VPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAP 1264
Query: 841 --PARPAP 846
P+ PAP
Sbjct: 1265 FSPSHPAP 1272
Score = 67.0 bits (162), Expect = 1e-10
Identities = 75/289 (25%), Positives = 121/289 (41%), Gaps = 42/289 (14%)
Query: 857 KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSH 916
K +GFGF I S P G ++ ++++ C L GD I +N Q++ LSH
Sbjct: 610 KGAQGFGFTIADS----PTG---QRVKQILD---IQGCPGLCEGDLIVEINQQNVQNLSH 659
Query: 917 DNIVQLIKDAGVTVTLTVIAEE-----------------EHHGPPSGTNSARQSPALQHR 959
+V ++KD + ++I E+ G P + SA P Q+
Sbjct: 660 TEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIP--QNL 717
Query: 960 PMGQS-QANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQ--PDTAVISVVGSRHNQN 1016
P + + P A + D Y S + ++ Q P T+ +
Sbjct: 718 PFPPALHRSSFPDSTEAFDPR-KPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKE 776
Query: 1017 LGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
L V L R GFGF + GG E + I + G A +DGR+H GD++V ++G P
Sbjct: 777 LD---VHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPV 833
Query: 1077 QGITHTRAIELIQ--AGGNKVLLLLRP----GTGLIPDHGLAPSGLCSY 1119
G TH I+L+ A +V L +R G P++G +P + ++
Sbjct: 834 AGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTH 882
Score = 53.9 bits (128), Expect = 8e-07
Identities = 56/199 (28%), Positives = 86/199 (43%), Gaps = 14/199 (7%)
Query: 413 LKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHAD 472
++K GFGF+I GG L V + +DGPA ++G++ GD I++ING THA
Sbjct: 1150 MEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHAR 1209
Query: 473 VVQMFQLVPVNQYVNLTLCRGY-PLPD-DSEDPVVDIVAATPVIN--GQSLTKGETCMNP 528
+++ + + V L L RG +P+ D P AA P + G SL G +P
Sbjct: 1210 AIELIK--SGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSP 1267
Query: 529 QDFKPGAMVLEQ--NGKSGHTLTGDGLNGPSDAS-----EQRVSMASSGSSQPELVTIP- 580
P + Q G + + P + S +QR+ S+ P+ P
Sbjct: 1268 SHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPR 1327
Query: 581 LIKGPKGFGFAIADSPTGQ 599
L + P G G A P +
Sbjct: 1328 LEEAPGGQGRPEAGRPASE 1346
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 934 bits (2413), Expect = 0.0
Identities = 532/1246 (42%), Positives = 723/1246 (58%), Gaps = 172/1246 (13%)
Query: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREE-----PGGG 55
MSK ++KK HW S+V EC V GP G+ G + GGAE GEFPY+G + PGGG
Sbjct: 1 MSKVIQKKNHWTSRVHECTVK-RGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGG 59
Query: 56 TCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRH 115
G G++LLEV G VSGL D L VI +E + K V+ G +NKDLRH
Sbjct: 60 -----EGPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRH 114
Query: 116 YLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESG 175
+L+ +FQKGS DH+LQQ IRDNLY +PCTTR+PR+GEVPGVDYNF++V++F LE+SG
Sbjct: 115 FLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSG 174
Query: 176 ALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSS 235
LLE GTY+GN+YGTPKPP++P + D + +S KRT S + M+
Sbjct: 175 TLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIV 234
Query: 236 LPEEEEDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQ------TNSSMDFRNYM--M 287
E EE++D +N S A++ E+ + P + T+ S F Y+
Sbjct: 235 HAENEEEDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLS 294
Query: 288 RDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAP-EDCEDGE------ 340
++ L PLP+NWEMAYT+ G +YFIDHNTKTT+WLDPR K + P E+CED E
Sbjct: 295 AEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEE 354
Query: 341 ------LPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQV----------- 383
LP GWEKIEDP YG YYVDH+N+KTQ+ENPV EAKRKKQL Q
Sbjct: 355 LDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQ 414
Query: 384 -------------------------------EIGSSKPDMEKSHFTRDPSQLKGVLVRAS 412
E P K FTR+PS+LKG +
Sbjct: 415 QQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTK 474
Query: 413 LKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHAD 472
L+KS+ GFGFT++GGD PDEFLQ+K+++ DGPAA DGK+ GDVIV +N CVLGHTHA
Sbjct: 475 LRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
Query: 473 VVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATP-------VINGQSLTKGETC 525
VV++FQ +P+ V+L LCRGYPLP D +DP +V + ++NGQ
Sbjct: 535 VVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPAS 594
Query: 526 MNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGP 585
+ + K M + + P+D VS+ASS ++QPEL+T+ ++KGP
Sbjct: 595 HSSKTGKVNGMKDARPSSPADVASNSSHGYPNDT----VSLASSIATQPELITVHIVKGP 650
Query: 586 KGFGFAIADSP--TGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFP 643
GFGF IADSP GQ+VK I+DS C+GL++GD+I E+ +NVQ LTH QVV++L + P
Sbjct: 651 MGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECP 710
Query: 644 VGADVPLLILRGGPPSPTKTAK--------MKTDKKENAGSLEAINEPIP----QPMP-F 690
G++V LL+ RGG P P K+ K + + + S +++ P Q +P F
Sbjct: 711 KGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEF 770
Query: 691 PPSIIR-------SGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGG 743
PP+ + SG K DP +++ +S+++YE++ P+ ++ D+FL ++E+GFGFR+LGG
Sbjct: 771 PPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGG 830
Query: 744 DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVL 803
+ P + IYIG I+PLGAA+ DGRLR+ DEL+C+DG PV GKSH+ V+ LM AA+ GHV
Sbjct: 831 NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVN 890
Query: 804 LTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQ---------------- 847
LTVRRK+ + + E++ S + + + E P
Sbjct: 891 LTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSG 950
Query: 848 ----------------EPYDVVLQRKENEGFGFVILTSKNKPPPG--------VIPHKIG 883
+PYDV ++R ENEGFGFVI++S ++P G +PHKIG
Sbjct: 951 IGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIG 1010
Query: 884 RVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
R+IEGSPADRCGKLKVGD I AVNG SI SH +IV LIK+AG TVTL +I +E
Sbjct: 1011 RIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNA 1070
Query: 944 PSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDT 1003
TN+ + + H P + E ++ + + S + K
Sbjct: 1071 TLLTNAEK---------IATITTTHTPSQQGTQE---TRNTTKPKQESQFEFK------- 1111
Query: 1004 AVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIH 1063
+ Q Y VELERG +GFGFSLRGG+EYNM L++LRLAEDGPA + G++
Sbjct: 1112 ------APQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMR 1165
Query: 1064 VGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDH 1109
+GD+I+EINGE T+ + H+RAIELI+ GG +V L L+ G G +P++
Sbjct: 1166 IGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY 1211
Score = 92.8 bits (229), Expect = 2e-18
Identities = 166/701 (23%), Positives = 265/701 (37%), Gaps = 116/701 (16%)
Query: 408 LVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLG 467
L+ + K MGFGFTI D P Q + D P + K GD+IV++N V
Sbjct: 641 LITVHIVKGPMGFGFTI--ADSPGGGGQRVKQIVDSPRCRGLK--EGDLIVEVNKKNVQA 696
Query: 468 HTHADVVQMFQLVPVNQYVNLTLCRG-YPLPDDS------EDPVVDIVAATPVINGQSLT 520
TH VV M P V L + RG P+P S E + V + +SL
Sbjct: 697 LTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLH 756
Query: 521 KGETCMNPQ---DFKPG-AMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPEL 576
+ Q +F P A +Q SG P Q SM + +
Sbjct: 757 TASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPD-----PFKIWAQSRSMYENRLPDYQE 811
Query: 577 VTIPLIKGPKGFGFAI-ADSPTGQKVKM----ILDSQWCQG-LQKGDIIKEIYHQNVQNL 630
I L + GFGF I + G+ + + L + G L+ GD + + V
Sbjct: 812 QDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGK 871
Query: 631 THLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPI------ 684
+H VV++++Q V L + R + KT + + A S + N+P
Sbjct: 872 SHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKT---ENEVPSPASSHHSSNQPASLTEEK 928
Query: 685 --PQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLG 742
PQ + + SGS + D+++ R + GFGF ++
Sbjct: 929 RTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEI-RRGENEGFGFVIVS 987
Query: 743 GDGPDQS------------IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVL 790
++ IG II A++ G+L+ D ++ ++G + KSH ++
Sbjct: 988 SVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIV 1047
Query: 791 DLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFIST---------------QNGSPRL 835
+L+ A TV +I P D+SS A + T Q G+
Sbjct: 1048 NLIKEAGN------TVTLRII-----PGDESSNATLLTNAEKIATITTTHTPSQQGTQET 1096
Query: 836 NRAEVPARPAP-----------QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGR 884
P + + Q+ Y V L+R +GFGF + + + + R
Sbjct: 1097 RNTTKPKQESQFEFKAPQATQEQDFYTVELERGA-KGFGFSLRGGREYN----MDLYVLR 1151
Query: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTV---------- 934
+ E PA+RCGK+++GD I +NG++ + H ++LIK+ G V L +
Sbjct: 1152 LAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY 1211
Query: 935 IAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGD--RSALEGE---IGKDVSTSYR 989
+ HGP +G + A R S + P D +S+ GE +D S
Sbjct: 1212 DPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSRE 1271
Query: 990 HSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRG 1030
+S ++H T SR + C P +R P G
Sbjct: 1272 YSRQPNEHHTWNGT-------SRKPDSGACRP--KDRAPEG 1303
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 928 bits (2399), Expect = 0.0
Identities = 537/1290 (41%), Positives = 734/1290 (56%), Gaps = 202/1290 (15%)
Query: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREE-----PGGG 55
MSK ++KK HW S+V EC V GP G+ G + GGAE GEFPY+G + PGGG
Sbjct: 1 MSKVIQKKNHWTSRVHECTVK-RGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGG 59
Query: 56 TCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRH 115
G G++LLEV G VSGL D L VI +E + K V+ G +NKDLRH
Sbjct: 60 -----EGPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRH 114
Query: 116 YLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESG 175
+L+ +FQKGS DH+LQQ IRDNLY +PCTTR+PR+GEVPGVDYNF++V++F LE+SG
Sbjct: 115 FLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSG 174
Query: 176 ALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSS 235
LLE GTY+GN+YGTPKPP++P + D + +S KRT S + M+
Sbjct: 175 TLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIV 234
Query: 236 LPEEEEDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQ-------TNSSMDFRNY--M 286
E EE++D +N S A++ E+ E + +P N T+ S F Y +
Sbjct: 235 HAENEEEDDVPEMNSSFTADSGEQ-EEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPL 293
Query: 287 MRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAP-EDCEDG------ 339
++ L PLP+NWEMAYT+ G +YFIDHNTKTT+WLDPR K + P E+CED
Sbjct: 294 SAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTE 353
Query: 340 ------ELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQ----------- 382
ELP GWEKIEDP YG YYVDH+N+KTQ+ENPV EAKRKKQL Q
Sbjct: 354 ELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQ 413
Query: 383 -------------------------------VEIGSSKPDMEKSHFTRDPSQLKGVLVRA 411
E P K FTR+PS+LKG +
Sbjct: 414 QQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHT 473
Query: 412 SLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471
L+KS+ GFGFT++GGD PDEFLQ+K+++ DGPAA DGK+ GDVIV +N CVLGHTHA
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 472 DVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATP-------VINGQSLTKGET 524
VV++FQ +P+ V+L LCRGYPLP D +DP +V + ++NGQ
Sbjct: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPA 593
Query: 525 CMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKG 584
+ + K M + + P+D VS+ASS ++QPEL+T+ ++KG
Sbjct: 594 SHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDT----VSLASSIATQPELITVHIVKG 649
Query: 585 PKGFGFAIADSP--TGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQF 642
P GFGF IADSP GQ+VK I+DS C+GL++GD+I E+ +NVQ LTH QVV++L +
Sbjct: 650 PMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVEC 709
Query: 643 PVGADVPLLILRGGPPSPTKTAK--------MKTDKKENAGSLEAINEPIP----QPMP- 689
P G++V LL+ RGG P P K+ K + + + S +++ P Q +P
Sbjct: 710 PKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPE 769
Query: 690 FPPSIIR-------SGSPKLDPSEVYLKSKTLYEDKP----------------------- 719
FPP+ + SG K DP +++ +S+++YE++P
Sbjct: 770 FPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNF 829
Query: 720 -----PNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELM 774
P+ ++ D+FL ++E+GFGFR+LGG+ P + IYIG I+PLGAA+ DGRLR+ DEL+
Sbjct: 830 GECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELI 889
Query: 775 CIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPR 834
C+DG PV GKSH+ V+ LM AA+ GHV LTVRRK+ + + E++ S + +
Sbjct: 890 CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP 949
Query: 835 LNRAEVPARPAPQ--------------------------------EPYDVVLQRKENEGF 862
+ E P +PYDV ++R ENEGF
Sbjct: 950 ASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGF 1009
Query: 863 GFVILTSKNKPPPG--------VIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVEL 914
GFVI++S ++P G +PHKIGR+IEGSPADRCGKLKVGD I AVNG SI
Sbjct: 1010 GFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNK 1069
Query: 915 SHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRS 974
SH +IV LIK+AG TVTL +I +E TN+ + + H P +
Sbjct: 1070 SHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEK---------IATITTTHTPSQQG 1120
Query: 975 ALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFS 1034
E ++ + + S + K + Q Y VELERG +GFGFS
Sbjct: 1121 TQE---TRNTTKPKQESQFEFK-------------APQATQEQDFYTVELERGAKGFGFS 1164
Query: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
LRGG+EYNM L++LRLAEDGPA + G++ +GD+I+EINGE T+ + H+RAIELI+ GG +
Sbjct: 1165 LRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRR 1224
Query: 1095 VLLLLRPGTGLIPDHGLAPSGLCSYVKPEQ 1124
V L L+ G G +P++ + P + + ++ E+
Sbjct: 1225 VRLFLKRGDGSVPEYAMIPPNIAACMRNEK 1254
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 924 bits (2389), Expect = 0.0
Identities = 536/1277 (41%), Positives = 727/1277 (56%), Gaps = 203/1277 (15%)
Query: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREE-----PGGG 55
MSK ++KK HW S+V EC V GP G+ G + GGAE GEFPY+G + PGGG
Sbjct: 1 MSKVIQKKNHWTSRVHECTVK-RGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGG 59
Query: 56 TCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRH 115
G G++LLEV G VSGL D L VI +E + K V+ G +NKDLRH
Sbjct: 60 -----EGPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRH 114
Query: 116 YLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESG 175
+L+ +FQKGS DH+LQQ IRDNLY +PCTTR+PR+GEVPGVDYNF++V++F LE+SG
Sbjct: 115 FLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSG 174
Query: 176 ALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSS 235
LLE GTY+GN+YGTPKPP++P + D + +S KRT S + M+
Sbjct: 175 TLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIV 234
Query: 236 LPEEEEDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQ-------TNSSMDFRNY--M 286
E EE++D +N S A++ E+ E + +P N T+ S F Y +
Sbjct: 235 HAENEEEDDVPEMNSSFTADSGEQ-EEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPL 293
Query: 287 MRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAP-EDCEDG------ 339
++ L PLP+NWEMAYT+ G +YFIDHNTKTT+WLDPR K + P E+CED
Sbjct: 294 SAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTE 353
Query: 340 ------ELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQ----------- 382
ELP GWEKIEDP YG YYVDH+N+KTQ+ENPV EAKRKKQL Q
Sbjct: 354 ELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQ 413
Query: 383 -------------------------------VEIGSSKPDMEKSHFTRDPSQLKGVLVRA 411
E P K FTR+PS+LKG +
Sbjct: 414 QQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHT 473
Query: 412 SLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471
L+KS+ GFGFT++GGD PDEFLQ+K+++ DGPAA DGK+ GDVIV +N CVLGHTHA
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 472 DVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATP-------VINGQSLTKGET 524
VV++FQ +P+ V+L LCRGYPLP D +DP +V + ++NGQ
Sbjct: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPA 593
Query: 525 CMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKG 584
+ + K M + + P+D VS+ASS ++QPEL+T+ ++KG
Sbjct: 594 SHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDT----VSLASSIATQPELITVHIVKG 649
Query: 585 PKGFGFAIADSP--TGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQF 642
P GFGF IADSP GQ+VK I+DS C+GL++GD+I E+ +NVQ LTH QVV++L +
Sbjct: 650 PMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVEC 709
Query: 643 PVGADVPLLILRGGPPSPTKTAK--------MKTDKKENAGSLEAINEPIP----QPMP- 689
P G++V LL+ RGG P P K+ K + + + S +++ P Q +P
Sbjct: 710 PKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPE 769
Query: 690 FPPSIIR-------SGSPKLDPSEVYLKSKTLYEDKP----------------------- 719
FPP+ + SG K DP +++ +S+++YE++P
Sbjct: 770 FPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNF 829
Query: 720 -----PNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELM 774
P+ ++ D+FL ++E+GFGFR+LGG+ P + IYIG I+PLGAA+ DGRLR+ DEL+
Sbjct: 830 GECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELI 889
Query: 775 CIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPR 834
C+DG PV GKSH+ V+ LM AA+ GHV LTVRRK+ + + E++ S + +
Sbjct: 890 CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP 949
Query: 835 LNRAEVPARPAPQ--------------------------------EPYDVVLQRKENEGF 862
+ E P +PYDV ++R ENEGF
Sbjct: 950 ASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGF 1009
Query: 863 GFVILTSKNKPPPG---------VIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVE 913
GFVI++S ++P G +PHKIGR+IEGSPADRCGKLKVGD I AVNG SI
Sbjct: 1010 GFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITN 1069
Query: 914 LSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDR 973
SH +IV LIK+AG TVTL +I +E TN+ + + H P +
Sbjct: 1070 KSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEK---------IATITTTHTPSQQ 1120
Query: 974 SALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGF 1033
E ++ + + S + K + Q Y VELERG +GFGF
Sbjct: 1121 GTQE---TRNTTKPKQESQFEFK-------------APQATQEQDFYTVELERGAKGFGF 1164
Query: 1034 SLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGN 1093
SLRGG+EYNM L++LRLAEDGPA + G++ +GD+I+EINGE T+ + H+RAIELI+ GG
Sbjct: 1165 SLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGR 1224
Query: 1094 KVLLLLRPGTGLIPDHG 1110
+V L L+ G G +P++G
Sbjct: 1225 RVRLFLKRGDGSVPEYG 1241
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 122 bits (305), Expect = 2e-27
Identities = 175/740 (23%), Positives = 296/740 (40%), Gaps = 93/740 (12%)
Query: 412 SLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471
++ K G T+ ++ + V++++ G ++DG+IA GD I+ IN + T+A
Sbjct: 1010 NIAKGNSSLGMTV-SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNA 1068
Query: 472 DVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDF 531
M + + + + Y + E+ + + + + + T + +
Sbjct: 1069 QARAMLRR---HSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPEL 1125
Query: 532 KPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFA 591
P E N P R S G S I G +G G
Sbjct: 1126 -PEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGIS---------IVGGRGMGSR 1175
Query: 592 IADSPT--GQKVKMILDSQWCQG---LQKGDIIKEIYHQNVQNLTHLQVVEVLKQF--PV 644
+++ G +K +L+ L+ GD I E+ ++++ +H Q VE +++ PV
Sbjct: 1176 LSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPV 1235
Query: 645 GADVPLLILRGGP-PSPT------------------KTAKMKTDKKENAGSLEAINEPIP 685
V +I R P P+ + ++ DK + E P+
Sbjct: 1236 VFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLC 1295
Query: 686 QPMPFPPSII--------RSGSPKLDPS-----EVYLKSKTLYEDKPPNTKDLDVF-LRK 731
P PPS +S + K+ E K + E T +L + L K
Sbjct: 1296 SVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEK 1355
Query: 732 QESGFGFRVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVL 790
SG G + G D S++I I P GAA KDGRL+ ADEL+ I+G + G+SH+
Sbjct: 1356 GHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNAS 1415
Query: 791 DLMTTAARNGHVLLTVRRK-------IFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPAR 843
++ A ++ +R K + G S+ + + P + ++
Sbjct: 1416 SIIKCAPSKVKIIF-IRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVD 1474
Query: 844 PAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHI 903
+ + + K+ G G I S+ GVI I + E A G+LKVGD I
Sbjct: 1475 LSSFKNVQHLELPKDQGGLGIAI--SEEDTLSGVI---IKSLTEHGVAATDGRLKVGDQI 1529
Query: 904 SAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEE-EHHGPPSGTNSARQSPALQHRPMG 962
AV+ + +V + + L+K A +TV LT+ AE + PS +A
Sbjct: 1530 LAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAA------SGEKKN 1583
Query: 963 QSQANHIPGDRSALEGEIGKDVSTSYRH-SWSDHKHLAQPDTAVISVVGSRHNQNLGCYP 1021
SQ+ +P + G S R+ S S + D A ++ GC
Sbjct: 1584 SSQSLMVP--------QSGSPEPESIRNTSRSSTPAIFASDPATCPIIP-------GCET 1628
Query: 1022 -VELERGPRGFGFSLRGGKEYNMGLFILR-LAEDGPAIKDGRIHVGDQIVEINGEPTQGI 1079
+E+ +G G G S+ GG + +G I+ + E+G A KDGR+ GDQI+E+NG +
Sbjct: 1629 TIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKA 1688
Query: 1080 THTRAIELIQAGGNKVLLLL 1099
TH AI +++ +V L L
Sbjct: 1689 THDEAINVLRQTPQRVRLTL 1708
Score = 99.0 bits (245), Expect = 2e-20
Identities = 149/705 (21%), Positives = 277/705 (39%), Gaps = 150/705 (21%)
Query: 404 LKGVLVRASLKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDING 462
L G L L+K G G ++ G DR + + + +G A +DG++ D +++ING
Sbjct: 1344 LTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
Query: 463 NCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKG 522
+ G +H + + + P S+ ++ + +N ++ G
Sbjct: 1404 QILYGRSHQNASSIIKCAP------------------SKVKII-FIRNKDAVNQMAVCPG 1444
Query: 523 ETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLI 582
N + P QN ++ T+T S+ V ++S + Q + +P
Sbjct: 1445 ----NAVEPLPSNSENLQNKETEPTVT---------TSDAAVDLSSFKNVQH--LELPKD 1489
Query: 583 KGPKGFGFAIADSPTGQKVKMILD---SQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVL 639
+G G + D+ +G +K + + + L+ GD I + + V + + +L
Sbjct: 1490 QGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLL 1549
Query: 640 KQFPVGADVPLLILRGGPPS---PTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIR 696
K + V L I P S P+ +KK ++ SL +PQ P IR
Sbjct: 1550 KTAKM--TVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSL-----MVPQSGSPEPESIR 1602
Query: 697 SGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGG-DGPDQSIYIGAI 755
+ S P+ ++ P +++ K +G G ++GG D +I I +
Sbjct: 1603 NTSRSSTPA-IFASDPATCPIIPGCETTIEI--SKGRTGLGLSIVGGSDTLLGAIIIHEV 1659
Query: 756 IPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEK 815
GAA KDGRL A D+++ ++GI ++ +H + ++++ + + L Y ++
Sbjct: 1660 YEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTL-------YRDE 1712
Query: 816 QPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPP 875
P + + + LQ+K +G G I+ +N
Sbjct: 1713 APYKEEEVC-----------------------DTLTIELQKKPGKGLGLSIVGKRN--DT 1747
Query: 876 GVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIK-DAGVTVTLTV 934
GV + +++G AD G+L GD I VNG+ + + + + L+K G + T
Sbjct: 1748 GVF---VSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTF 1804
Query: 935 IAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSD 994
P SG+++ S++ ++AL EI
Sbjct: 1805 --------PLSGSST--------------SESLESSSKKNALASEI-------------- 1828
Query: 995 HKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPR-GFGFSLRGGKEYNMG---LFILRL 1050
G VE+++GP G S+ GG +G +FI +
Sbjct: 1829 ----------------------QGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMM 1866
Query: 1051 AEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKV 1095
G A + ++ VGD+IV I G T+G+THT+A+ L++ +
Sbjct: 1867 HPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSI 1911
Score = 94.4 bits (233), Expect = 6e-19
Identities = 177/799 (22%), Positives = 304/799 (38%), Gaps = 182/799 (22%)
Query: 393 EKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIG---GDRPDEFLQVKNVLKDGPAAQDG 449
E ++ +Q + V V LK + G GF+++G +R + + V+ + + A +DG
Sbjct: 121 EFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDG 180
Query: 450 KIAPGDVIVDINGNCV-LGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIV 508
++ D I+ ING + TH + + Q V L + RG LP
Sbjct: 181 RLKETDQILAINGQALDQTITHQQAISILQ--KAKDTVQLVIARG-SLPQ---------- 227
Query: 509 AATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMAS 568
+P+++ PS AS +S S
Sbjct: 228 LVSPIVS--------------------------------------RSPSAAST--ISAHS 247
Query: 569 SGSSQPELVTIPLIKGPKGFGFAI-ADSPTGQKVKMILDSQWCQG---LQKGDIIKEIYH 624
+ + TI L+ G GF I TG VK IL L GD I +I
Sbjct: 248 NPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGD 307
Query: 625 QNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPI 684
++ ++ QV +VL+Q G V L+I RG AI E
Sbjct: 308 TDLAGMSSEQVAQVLRQ--CGNRVKLMIARG-----------------------AIEE-- 340
Query: 685 PQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGD 744
+ P I S SP P E+ + + T K ++ DV L K G G + G
Sbjct: 341 -RTAPTALGITLSSSPTSTP-ELRVDAST---QKGEESETFDVELTKNVQGLGITIAGYI 395
Query: 745 GPDQ----SIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNG 800
G + I++ +I A E DGR++ D+++ +DG ++G +++Q ++++ +
Sbjct: 396 GDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQT- 454
Query: 801 HVLLTVRRKIFYGEKQ---PEDDSSQAFISTQNGS------------------------- 832
VLLT+ R+ E + ED + A +S N S
Sbjct: 455 -VLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTE 513
Query: 833 ----PRLNRAEVPARPAPQEP--------------YDVVLQR----KENEGFGFVILTSK 870
P L+ A ++ Y++V+ EN G G + +
Sbjct: 514 EEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT- 572
Query: 871 NKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTV 930
V H I V+ P GKL GD + VNG +++ +H ++V ++K+ + V
Sbjct: 573 ------VGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEV 626
Query: 931 TLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRH 990
T+ P T S S L + ++ H+ ++G+ + +S
Sbjct: 627 TMVCCRRTV----PPTTQSELDS--LDLCDIELTEKPHV---------DLGEFIGSSE-- 669
Query: 991 SWSDHKHLAQPDT--AVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKE----YNMG 1044
++ LA D + V G +ELE+G +G GFS+ ++ +
Sbjct: 670 --TEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTV 727
Query: 1045 LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ-AGGNKVLLLLRPGT 1103
+ I L G A KDGR+ GD+++ +N + + A+E ++ A V + +
Sbjct: 728 IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPL 787
Query: 1104 GLIPDHGLAPSGLCSYVKP 1122
L P+ G + S++ P
Sbjct: 788 PLSPEEGYVSAKEDSFLYP 806
Score = 92.4 bits (228), Expect = 2e-18
Identities = 90/401 (22%), Positives = 161/401 (40%), Gaps = 82/401 (20%)
Query: 713 TLYEDKPPNTKD-----LDVFLRKQES-GFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGR 766
TLY D+ P ++ L + L+K+ G G ++G D +++ I+ G A+ DGR
Sbjct: 1707 TLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN-DTGVFVSDIVKGGIADADGR 1765
Query: 767 LRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFI 826
L D+++ ++G V+ + + V L+ + + S +F
Sbjct: 1766 LMQGDQILMVNGEDVRNATQEAVAALLKVS----------------------EGSLSSFT 1803
Query: 827 STQNGSPRLNRAEVPARPAP-----QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHK 881
+GS E ++ Q V +++ + G I P G +P
Sbjct: 1804 FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPL-GDVPIF 1862
Query: 882 IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHH 941
I + A + KL+VGD I + G S ++H V L+K+A ++ + V+A
Sbjct: 1863 IAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAG---- 1918
Query: 942 GPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQP 1001
GD S + G + S+S + + Q
Sbjct: 1919 -----------------------------GDVSVVTGHQQEPASSSLSFTGLTSSSIFQD 1949
Query: 1002 DTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGG---KEYNMGLFILRLAEDGPAIK 1058
D C + LERGP G GFS+ GG ++ +++ + G A +
Sbjct: 1950 DLGPPQ-----------CKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASE 1998
Query: 1059 DGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
DGR+ GDQI+ +NG+ +G+TH A+ +++ V L++
Sbjct: 1999 DGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 89.0 bits (219), Expect = 2e-17
Identities = 134/611 (21%), Positives = 229/611 (37%), Gaps = 93/611 (15%)
Query: 388 SKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQ 447
++P + S D S K V L K G G I D + +K++ + G AA
Sbjct: 1462 TEPTVTTSDAAVDLSSFKNVQ-HLELPKDQGGLGIAISEEDTLSGVI-IKSLTEHGVAAT 1519
Query: 448 DGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDI 507
DG++ GD I+ ++ V+G+ + + + + V LT+ P DS+ +
Sbjct: 1520 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMT--VKLTIHAENP---DSQA----V 1570
Query: 508 VAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMA 567
+A +G+ ++ M PQ P + +S AS+
Sbjct: 1571 PSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIF--------ASDPATCPI 1622
Query: 568 SSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQG-------LQKGDIIK 620
G TI + KG G G +I +I+ + +G L GD I
Sbjct: 1623 IPGCE----TTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQIL 1678
Query: 621 EIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTK----TAKMKTDKKENAGS 676
E+ +++ TH + + VL+Q P V L + R P + T ++ KK G
Sbjct: 1679 EVNGIDLRKATHDEAINVLRQTP--QRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGL 1736
Query: 677 LEAINEPIPQPMPFPPSIIRSGSPKLDP------------------------------SE 706
+I F I++ G D SE
Sbjct: 1737 GLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSE 1796
Query: 707 VYLKSKTLYEDKPPNTKDLDVFLRKQE------------------SGFGFRVLGGDGP-- 746
L S T ++ L+ +K G + GG G
Sbjct: 1797 GSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPL 1856
Query: 747 -DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLT 805
D I+I + P G A + +LR D ++ I G +G +H Q ++L+ A+ + + +
Sbjct: 1857 GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVV 1916
Query: 806 VRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFV 865
+ ++ +S + T S + + ++ P + + L+R +G GF
Sbjct: 1917 AGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDL----GPPQCKSITLERGP-DGLGFS 1971
Query: 866 ILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKD 925
I+ P G +P + V A G+LK GD I AVNGQS+ ++H+ V ++K
Sbjct: 1972 IVGGYGSPH-GDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKR 2030
Query: 926 AGVTVTLTVIA 936
TVTL V++
Sbjct: 2031 TKGTVTLMVLS 2041
Score = 86.7 bits (213), Expect = 1e-16
Identities = 101/440 (22%), Positives = 176/440 (40%), Gaps = 91/440 (20%)
Query: 673 NAGSLEAINEP-IPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVF--L 729
N G+LEA+ P IP +G P D + +K+ + ++VF L
Sbjct: 98 NNGNLEALTGPGIPHI---------NGKPACDEFDQLIKNMA-------QGRHVEVFELL 141
Query: 730 RKQESGFGFRVLGGDGPDQS---IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGK-S 785
+ G GF V+G ++ I++ I A +DGRL+ D+++ I+G + +
Sbjct: 142 KPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTIT 201
Query: 786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPA 845
H+Q + ++ A V L + R P S + ST + + P
Sbjct: 202 HQQAISILQKAKDT--VQLVIARGSLPQLVSPIVSRSPSAASTISAH---------SNPV 250
Query: 846 PQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISA 905
+ + + + G GF I+ K GVI + ++ G AD+ G+L GDHI
Sbjct: 251 HWQHMETIELVNDGSGLGFGIIGGK---ATGVI---VKTILPGGVADQHGRLCSGDHILK 304
Query: 906 VNGQSIVELSHDNIVQLIKDAGVTVTLTVI--AEEEHHGPPSGTNSARQSPALQHRPMGQ 963
+ + +S + + Q+++ G V L + A EE P + + SP
Sbjct: 305 IGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSP--------- 355
Query: 964 SQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVE 1023
+ + D S +GE + + VE
Sbjct: 356 TSTPELRVDASTQKGEESET------------------------------------FDVE 379
Query: 1024 LERGPRGFGFSLRG----GKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGI 1079
L + +G G ++ G K G+F+ + + DGRI +GDQI+ ++G QG
Sbjct: 380 LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF 439
Query: 1080 THTRAIELIQAGGNKVLLLL 1099
T+ +A+E+++ G VLL L
Sbjct: 440 TNQQAVEVLRHTGQTVLLTL 459
Score = 73.9 bits (180), Expect = 8e-13
Identities = 128/595 (21%), Positives = 226/595 (37%), Gaps = 106/595 (17%)
Query: 535 AMVLEQNGKSGHTLTGDGL---NGPS--DASEQRVSMASSGSSQPELVTIPLIKGPKG-F 588
+ +L N + LTG G+ NG D +Q + + G + L+K P G
Sbjct: 92 SFLLSPNNGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGR---HVEVFELLKPPSGGL 148
Query: 589 GFAIADSPTGQKVKMILDSQWCQG---------LQKGDIIKEIYHQNV-QNLTHLQVVEV 638
GF++ + + ++ + Q Q L++ D I I Q + Q +TH Q + +
Sbjct: 149 GFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISI 208
Query: 639 LKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSG 698
L++ V L+I RG SL + PI P S I +
Sbjct: 209 LQK--AKDTVQLVIARG--------------------SLPQLVSPIVSRSPSAASTISAH 246
Query: 699 SPKLDPSEVYLKSKTLYEDKPPNTKDLDVF-LRKQESGFGFRVLGGDGPDQSIYIGAIIP 757
S P + + ++ L SG GF ++GG + + I+P
Sbjct: 247 S------------------NPVHWQHMETIELVNDGSGLGFGIIGGKAT--GVIVKTILP 286
Query: 758 LGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQP 817
G A++ GRL + D ++ I + G S +QV ++ N L+ R I E+
Sbjct: 287 GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCG-NRVKLMIARGAI--EERTA 343
Query: 818 EDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVI---LTSKNKPP 874
S+ +P L + E +DV L K +G G I + K P
Sbjct: 344 PTALGITLSSSPTSTPELRVDASTQKGEESETFDVELT-KNVQGLGITIAGYIGDKKLEP 402
Query: 875 PGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTV 934
G+ + + + S + G++++GD I AV+G ++ ++ V++++ G TV LT+
Sbjct: 403 SGIF---VKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTL 459
Query: 935 IAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVS--TSYRH-- 990
+ +Q L R A+ P + S ++ KD +S R+
Sbjct: 460 M-----------RRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTN 508
Query: 991 -------------SWSDHKHLAQPDTAVISVVGSR---HNQNLGCYPVELERGPRGFGFS 1034
+ + AQ A + R N + V G G S
Sbjct: 509 ILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGIS 568
Query: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
L ++ FI + +GP G++ GD+++E+NG G H + +++
Sbjct: 569 LEATVGHH---FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILK 620
Score = 72.8 bits (177), Expect = 2e-12
Identities = 145/731 (19%), Positives = 269/731 (36%), Gaps = 89/731 (12%)
Query: 413 LKKSTMGFGFTIIG--GDRPDE--FLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGH 468
L K+ G G TI G GD+ E + VK++ K DG+I GD I+ ++G + G
Sbjct: 380 LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF 439
Query: 469 THADVVQMFQLVPVNQYVNLTLCRGYPLPDD---SEDPVVDIVAATPVINGQSLTKGETC 525
T+ V++ + Q V LTL R + S + V +PV S+ K E
Sbjct: 440 TNQQAVEVLR--HTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPV--NASIIK-ENY 494
Query: 526 MNPQDFKPGAMVLE--QNGKSGHTLTGDGLNGPSDASEQRVSMASSGSS----QPELVTI 579
+DF + G+ L + DA +Q ++ + E+V
Sbjct: 495 EKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVA 554
Query: 580 PLIKGPKGFGFAIA---------------DSPTGQKVKMILDSQWCQGLQKGDIIKEIYH 624
+ K + G I+ + P G K+ GD + E+
Sbjct: 555 HVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLF----------SGDELLEVNG 604
Query: 625 QNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPI 684
+ H VV +LK+ P+ +V ++ R P T++ D + +E +P
Sbjct: 605 ITLLGENHQDVVNILKELPI--EVTMVCCRRTVPPTTQSELDSLDLCD----IELTEKPH 658
Query: 685 PQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLD-VFLRKQESGFGFRVLGG 743
F S + P L ++ ++ + + + L K G GF +L
Sbjct: 659 VDLGEFIGSS-ETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDY 717
Query: 744 DGP----DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARN 799
P I I +++P G AEKDGRL D LM ++ + ++ S ++ ++ + A +
Sbjct: 718 QDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL-KGAPS 776
Query: 800 GHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGS---PRLNRAEVPARPAPQEPYDVVLQR 856
G V + V + + PE + ++S + S P + E P D+ L
Sbjct: 777 GTVRIGVAKPL---PLSPE----EGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVG 829
Query: 857 KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGK-LKVGDHISAVNGQSIVELS 915
+ P + I CG L G + + + ++E S
Sbjct: 830 TNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENS 889
Query: 916 HDNIVQLIKDAGVTVTLTVIAEEEHH--------GPPSGTNSARQSPALQHRPMGQSQ-- 965
D ++ L T ++ ++ + GP SG +PA + +
Sbjct: 890 CDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENT 949
Query: 966 ----ANHIPGD---RSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLG 1018
+H+P + + L + + + ++ V +
Sbjct: 950 IVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFER-- 1007
Query: 1019 CYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQG 1078
+ + +G G ++ K+ +G+ + + G +DGRI +GD I+ IN E T
Sbjct: 1008 --TINIAKGNSSLGMTVSANKD-GLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
Query: 1079 ITHTRAIELIQ 1089
+T+ +A +++
Sbjct: 1065 VTNAQARAMLR 1075
Score = 70.1 bits (170), Expect = 1e-11
Identities = 74/283 (26%), Positives = 126/283 (44%), Gaps = 43/283 (15%)
Query: 857 KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSH 916
K N G + S NK G+I + +I G R G++ +GD I ++N +S + +++
Sbjct: 1013 KGNSSLGMTV--SANKDGLGMI---VRSIIHGGAISRDGRIAIGDCILSINEESTISVTN 1067
Query: 917 DNIVQLIKD---AGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANH-IPG- 971
+++ G + +T + E H + +QS + + S IP
Sbjct: 1068 AQARAMLRRHSLIGPDIKITYVPAE--HLEEFKISLGQQSGRVMALDIFSSYTGRDIPEL 1125
Query: 972 -DRSALEGEIGKDVSTSYRHSWSDHKHLA---QPDTAV-ISVVGSRHNQNLGCYPVELER 1026
+R EGE + +T+Y + W+ + + +P ++ IS+VG R
Sbjct: 1126 PEREEGEGEESELQNTAYSN-WNQPRRVELWREPSKSLGISIVGGR-------------- 1170
Query: 1027 GPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIE 1086
G G L G E G+FI + ED PA K+G + GD+IVE++G + +H +A+E
Sbjct: 1171 ---GMGSRLSNG-EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVE 1226
Query: 1087 LIQAGGNKVLLLL-----RPGTGLIPD--HGLAPSGLCSYVKP 1122
I+ GN V+ ++ RP +P H L P S P
Sbjct: 1227 AIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNP 1269
Score = 44.7 bits (104), Expect = 5e-04
Identities = 28/94 (29%), Positives = 46/94 (48%), Gaps = 2/94 (2%)
Query: 1022 VELERGP-RGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT 1080
+EL++ P +G G S+ G K + G+F+ + + G A DGR+ GDQI+ +NGE + T
Sbjct: 1726 IELQKKPGKGLGLSIVG-KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT 1784
Query: 1081 HTRAIELIQAGGNKVLLLLRPGTGLIPDHGLAPS 1114
L++ + P +G L S
Sbjct: 1785 QEAVAALLKVSEGSLSSFTFPLSGSSTSESLESS 1818
Score = 32.3 bits (72), Expect = 2.6
Identities = 13/39 (33%), Positives = 24/39 (61%)
Query: 68 GDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPG 106
GD ++ V+GT + G TN+ + V+RH + + L ++ G
Sbjct: 425 GDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRG 463
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 114 bits (284), Expect = 7e-25
Identities = 166/770 (21%), Positives = 296/770 (38%), Gaps = 156/770 (20%)
Query: 414 KKSTMGFGFTIIGGDRPDEFLQ---------VKNVLKDGPAAQDGKIAPGDVIVDINGNC 464
++ + G +I+GG + L+ +K VL+D PA + + GD I++++G
Sbjct: 1073 REPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVD 1132
Query: 465 VLGHTHADVVQMFQLV--PVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKG 522
+ +H++ V+ + PV V +P+ A + Q+
Sbjct: 1133 LQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNK-------ANKITGNQNQDTQ 1185
Query: 523 ETCMNPQDFKPGAMVLEQNGKSGHTLTGDG-LNGPSDASEQRVSMASSGSSQPELVTIPL 581
E Q P M L K+ LT D N DA + EL I L
Sbjct: 1186 EKKEKRQGTAPPPMKLPPPYKA---LTDDSDENEEEDAFTDQKIRQRYADLPGELHIIEL 1242
Query: 582 IKGPKGFGFAIADSPTGQKVKMILDSQWCQG-------LQKGDIIKEIYHQNVQNLTHLQ 634
K G G ++A + ++ + + +G ++ GD + EI +Q + +H
Sbjct: 1243 EKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQN 1302
Query: 635 VVEVLKQFPVGADVPLLILRGGP----------PSPTKTAKMKTDKK-------ENAGSL 677
++K P + V L+ +R P P+ + D+ E GS+
Sbjct: 1303 ASAIIKTAP--SKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSV 1360
Query: 678 EAINEPIPQPMPFPPSIIRSGSPK------LDPSEVYLKSKTLYEDKP------------ 719
E + +P+ F ++ + K E+ L + Y
Sbjct: 1361 EVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAP 1420
Query: 720 ----PNT------KDLDVFLRKQESGFGFRVLGG-DGPDQSIYIGAIIPLGAAEKDGRLR 768
P T +++ + + K SG G ++GG D P +I I + GAA +DGRL
Sbjct: 1421 LSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLW 1480
Query: 769 AADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFIST 828
A D+++ ++G+ ++ SH++ + + + VR ++ E D+ +
Sbjct: 1481 AGDQILEVNGVDLRNSSHEEAITALRQTPQK------VRLVVYRDEAHYRDEENL----- 1529
Query: 829 QNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEG 888
E + V LQ+K G G I+ +N GV I +++G
Sbjct: 1530 -------------------EIFPVDLQKKAGRGLGLSIVGKRNGS--GVF---ISDIVKG 1565
Query: 889 SPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTN 948
AD G+L GD I +VNG+ + S + + ++K A V L +
Sbjct: 1566 GAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEI-------------- 1611
Query: 949 SARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISV 1008
G+ +A R+ + G S HS S H A T + ++
Sbjct: 1612 -------------GRLRAGSWTSARTTSQNSQGSQQSA---HS-SCHPSFAPVITGLQNL 1654
Query: 1009 VG-------SRHNQNLGCYP--VELERG-PRGFGFSLRGGKEYNMG---LFILRLAEDGP 1055
VG S+ N P VE+ R G S+ GG+ +G +FI + G
Sbjct: 1655 VGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGV 1714
Query: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGL 1105
A + ++ VGD+IV ING+P G++H + L++ +++L + T +
Sbjct: 1715 AARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI 1764
Score = 73.9 bits (180), Expect = 8e-13
Identities = 61/222 (27%), Positives = 105/222 (47%), Gaps = 31/222 (13%)
Query: 726 DVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKS 785
+V L SG GF ++GG + + I+P G A++DGRL+ D ++ I G V+G +
Sbjct: 248 EVELINDGSGLGFGIVGGK--TSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMT 305
Query: 786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVP--AR 843
+QV ++ + +L+ + P D IS +P +P A
Sbjct: 306 SEQVAQVLRNCGNSVRMLVA---------RDPAGD-----ISVTPPAPAALPVALPTVAS 351
Query: 844 PAPQ------EPYDVVLQRKENEGFGFVIL----TSKNKPPPGVIPHKIGRVIEGSPADR 893
P E Y+V L RK+ + G I+ TS G+ + +I GS A
Sbjct: 352 KGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIY---VKSIIPGSAAYH 408
Query: 894 CGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVI 935
G ++V D I AV+G +I ++ ++V+++++AG V LT++
Sbjct: 409 NGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV 450
Score = 72.0 bits (175), Expect = 3e-12
Identities = 76/291 (26%), Positives = 126/291 (43%), Gaps = 39/291 (13%)
Query: 707 VYLKSKTLYEDKPPNTKDLDVFLRKQES-GFGFRVLGGDGPDQSIYIGAIIPLGAAEKDG 765
V + + Y D+ N + V L+K+ G G ++G ++I I+ GAA+ DG
Sbjct: 1515 VVYRDEAHYRDEE-NLEIFPVDLQKKAGRGLGLSIVGKRN-GSGVFISDIVKGGAADLDG 1572
Query: 766 RLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRR-------------KIFY 812
RL D+++ ++G ++ S + V ++ A G V L + R +
Sbjct: 1573 RLIQGDQILSVNGEDMRNASQETVATILKCA--QGLVQLEIGRLRAGSWTSARTTSQNSQ 1630
Query: 813 GEKQPEDDS-----SQAFISTQN--GSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFV 865
G +Q S + QN G+ R++ EP V + R+ ++ G
Sbjct: 1631 GSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGIS 1690
Query: 866 ILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKD 925
I + P G IP I + A R KLKVGD I ++NGQ + LSH ++V L+K+
Sbjct: 1691 IAGGRGSPL-GDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKN 1749
Query: 926 AGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRP----MGQSQANHIPGD 972
A + L V+A+ TN + + L++ +G A H P D
Sbjct: 1750 AYGRIILQVVAD---------TNISAIAAQLENMSTGYHLGSPTAEHHPED 1791
Score = 67.0 bits (162), Expect = 1e-10
Identities = 66/240 (27%), Positives = 110/240 (45%), Gaps = 44/240 (18%)
Query: 579 IPLIKGPKGFGFAIADSPT-GQKVKMILDSQWCQG---LQKGDIIKEIYHQNVQNLTHLQ 634
+ LI G GF I T G V+ I+ LQ GD I +I NVQ +T Q
Sbjct: 249 VELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQ 308
Query: 635 VVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSI 694
V +VL+ G V +L+ R + AG + ++ P P +P
Sbjct: 309 VAQVLRN--CGNSVRMLVAR-----------------DPAGDI-SVTPPAPAALPVALPT 348
Query: 695 IRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQS----- 749
+ S P D S L+E T ++++ +RK G R++G G +
Sbjct: 349 VASKGPGSDSS--------LFE-----TYNVEL-VRKDGQSLGIRIVGYVGTSHTGEASG 394
Query: 750 IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRK 809
IY+ +IIP AA +G ++ D+++ +DG+ ++G ++ V++++ A + H+ L VRRK
Sbjct: 395 IYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTL-VRRK 453
Score = 66.2 bits (160), Expect = 2e-10
Identities = 81/375 (21%), Positives = 150/375 (40%), Gaps = 69/375 (18%)
Query: 730 RKQESGFGFRVLGGDGPDQS---IYIGAIIPLGAAEKDGRLRAADELMCIDGIPV-KGKS 785
R G GF V+ + I++ + P A++D RL+ D+++ I+ P+ + S
Sbjct: 139 RPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
Query: 786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPA 845
H+Q + L+ G + L V R+ + + + S LN +P
Sbjct: 199 HQQAIALLQQTT--GSLRLIVAREPVH--------------TKSSTSSSLNDTTLPETVC 242
Query: 846 PQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISA 905
+V L + G GF I+ K GV+ + ++ G ADR G+L+ GDHI
Sbjct: 243 WGHVEEVELIN-DGSGLGFGIVGGKTS---GVV---VRTIVPGGLADRDGRLQTGDHILK 295
Query: 906 VNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMG-QS 964
+ G ++ ++ + + Q++++ G +V + V + P+G S PA P+ +
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD------PAGDISV-TPPAPAALPVALPT 348
Query: 965 QANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL 1024
A+ PG S+L ++ S ++ VG+ H
Sbjct: 349 VASKGPGSDSSLFETYNVELVRKDGQSLG---------IRIVGYVGTSHTGEAS------ 393
Query: 1025 ERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRA 1084
G+++ + A +G I V D+IV ++G QG +
Sbjct: 394 -------------------GIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDV 434
Query: 1085 IELIQAGGNKVLLLL 1099
+E+++ G V L L
Sbjct: 435 VEVLRNAGQVVHLTL 449
Score = 54.3 bits (129), Expect = 6e-07
Identities = 66/258 (25%), Positives = 100/258 (38%), Gaps = 63/258 (24%)
Query: 861 GFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVE-LSHDNI 919
GF V L S+N G + + V GS ADR +LK D I A+N + + +SH
Sbjct: 146 GFSVVALRSQNL---GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQA 202
Query: 920 VQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGE 979
+ L++ ++ L V E P T S+ S
Sbjct: 203 IALLQQTTGSLRLIVARE------PVHTKSSTSS-------------------------- 230
Query: 980 IGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGK 1039
+ DT + V H + VEL G GF + GGK
Sbjct: 231 -------------------SLNDTTLPETVCWGHVEE-----VELINDGSGLGFGIVGGK 266
Query: 1040 EYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKV-LLL 1098
G+ + + G A +DGR+ GD I++I G QG+T + ++++ GN V +L+
Sbjct: 267 --TSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLV 324
Query: 1099 LRPGTGLIPDHGLAPSGL 1116
R G I AP+ L
Sbjct: 325 ARDPAGDISVTPPAPAAL 342
Score = 52.4 bits (124), Expect = 2e-06
Identities = 58/279 (20%), Positives = 106/279 (37%), Gaps = 37/279 (13%)
Query: 402 SQLKGVLVRASLKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDI 460
+ L G L L+K G G ++ G DR + V + +GPAA DG++ GD +++I
Sbjct: 1231 ADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEI 1290
Query: 461 NGNCVLGHTHADVVQMFQLVPV---------NQYVNLTLCRGYPLPDDSEDPVVDIVAAT 511
N + G +H + + + P VN +P+P S + D
Sbjct: 1291 NNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTE 1350
Query: 512 PVINGQ--SLTKG-ETCMNPQDFKPGAMVLEQN-----------------GKSGHTLTGD 551
P+ + + S+ G + + FK ++Q S H+ D
Sbjct: 1351 PISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDAD 1410
Query: 552 GLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQ 611
+ V A+ + + I + KG G G +I +++ + +
Sbjct: 1411 FTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEE 1470
Query: 612 G-------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFP 643
G L GD I E+ +++N +H + + L+Q P
Sbjct: 1471 GAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTP 1509
Score = 52.0 bits (123), Expect = 3e-06
Identities = 30/89 (33%), Positives = 49/89 (55%), Gaps = 10/89 (11%)
Query: 1022 VELERGPR-GFGFSLRGGK---------EYNMGLFILRLAEDGPAIKDGRIHVGDQIVEI 1071
VE+ R P G S+ GG+ E G+FI ++ ED PA K + GD+I+E+
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
Query: 1072 NGEPTQGITHTRAIELIQAGGNKVLLLLR 1100
+G Q +H+ A+E I+ GN V+ +++
Sbjct: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
Score = 47.4 bits (111), Expect = 8e-05
Identities = 120/566 (21%), Positives = 201/566 (35%), Gaps = 124/566 (21%)
Query: 419 GFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQ 478
G GF I+GG + V+ ++ G A +DG++ GD I+ I G V G T V Q+
Sbjct: 257 GLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQV-- 312
Query: 479 LVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVL 538
L V + + R DP DI P P A+ +
Sbjct: 313 LRNCGNSVRMLVAR---------DPAGDISVTPPA-------------------PAALPV 344
Query: 539 EQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIK------GPKGFGFAI 592
L GP S SS E + L++ G + G+ +
Sbjct: 345 --------ALPTVASKGP-----------GSDSSLFETYNVELVRKDGQSLGIRIVGY-V 384
Query: 593 ADSPTGQK----VKMIL--DSQWCQG-LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVG 645
S TG+ VK I+ + + G +Q D I + N+Q + VVEVL+ G
Sbjct: 385 GTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRN--AG 442
Query: 646 ADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPS 705
V L ++R S T + +D+ + EP+ P F + + +D
Sbjct: 443 QVVHLTLVRRKTSSSTSPLEPPSDR-------GTVVEPLKPPALFLTGAVET-ETNVDGE 494
Query: 706 EVYLKSK--TLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSI------------- 750
+ +K + TL D + L+ E+ R GPD +
Sbjct: 495 DEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDA 554
Query: 751 ---------------------------YIGAIIPLGAAEKDGRLRAADELMCIDGIPVKG 783
YI +I+ G + G L+ DEL+ ++G+ + G
Sbjct: 555 ELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYG 614
Query: 784 KSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPED----DSSQAFISTQNGSPRLNRAE 839
KS ++ + + L R++F E ++ ++S + +
Sbjct: 615 KSRREAVSFLKEVP--PPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEED 672
Query: 840 VPARPAPQEP-YDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLK 898
A P +V K+ +G GF IL ++ P I ++ A+R G L
Sbjct: 673 DDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLL 732
Query: 899 VGDHISAVNGQSIVELSHDNIVQLIK 924
GD + +VN + S V+++K
Sbjct: 733 PGDRLVSVNEYCLDNTSLAEAVEILK 758
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/94 (29%), Positives = 53/94 (56%), Gaps = 7/94 (7%)
Query: 413 LKKSTMGFGFTIIGGDRPDE----FLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGH 468
L K G GF+I+ P + + +++++ DG A + G + PGD +V +N C+
Sbjct: 689 LVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNT 748
Query: 469 THADVVQMFQLVPVNQYVNLTLCRGYPLPDDSED 502
+ A+ V++ + VP V+L +C+ PL +D+E+
Sbjct: 749 SLAEAVEILKAVPPG-LVHLGICK--PLVEDNEE 779
Score = 46.2 bits (108), Expect = 2e-04
Identities = 25/81 (30%), Positives = 44/81 (54%), Gaps = 3/81 (3%)
Query: 413 LKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471
+ K G G +I+GG D P + + V ++G AA+DG++ GD I+++NG + +H
Sbjct: 1440 ISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHE 1499
Query: 472 DVVQMFQLVPVNQYVNLTLCR 492
+ + + P Q V L + R
Sbjct: 1500 EAITALRQTP--QKVRLVVYR 1518
Score = 38.9 bits (89), Expect = 0.028
Identities = 42/215 (19%), Positives = 80/215 (37%), Gaps = 40/215 (18%)
Query: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
H I ++ G P D G L+ D + VNG + S V +K+ V T++
Sbjct: 581 HYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKE--VPPPFTLVCCRR 638
Query: 940 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 999
+ + R++ + S E E+ ++ + L
Sbjct: 639 LFDDEASVDEPRRT------------------ETSLPETEVDHNMDVNTEEDDDGELALW 680
Query: 1000 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1055
P+ + VEL + +G GFS+ + + + ++R L DG
Sbjct: 681 SPEVKI----------------VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGV 724
Query: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQA 1090
A + G + GD++V +N + A+E+++A
Sbjct: 725 AERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKA 759
Score = 37.7 bits (86), Expect = 0.062
Identities = 26/83 (31%), Positives = 44/83 (53%), Gaps = 5/83 (6%)
Query: 1022 VELER-GPRGFGFSLRGGKEYNMG---LFILRLAEDGPAIKDGRIHVGDQIVEINGEP-T 1076
+++ER G GFS+ + N+G +F+ + A +D R+ DQI+ IN P
Sbjct: 135 IDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLD 194
Query: 1077 QGITHTRAIELIQAGGNKVLLLL 1099
Q I+H +AI L+Q + L++
Sbjct: 195 QNISHQQAIALLQQTTGSLRLIV 217
Score = 36.6 bits (83), Expect = 0.14
Identities = 55/264 (20%), Positives = 96/264 (36%), Gaps = 54/264 (20%)
Query: 436 VKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYP 495
+ +++ GP G + P D ++++NG + G + + V + VP L CR
Sbjct: 583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPP--FTLVCCRR-- 638
Query: 496 LPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNG 555
L DD VD T ++ +N ++ G + L
Sbjct: 639 LFDDEAS--VDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWS--------------- 681
Query: 556 PSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD-----SPTGQKV---KMILD- 606
PE+ + L+K KG GF+I D PT + ++ D
Sbjct: 682 ------------------PEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADG 723
Query: 607 -SQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFP-----VGADVPLLILRGGPPSP 660
++ GL GD + + + N + + VE+LK P +G PL+
Sbjct: 724 VAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCY 783
Query: 661 TKTAKMKTDKKENAGSLEAINEPI 684
+ DK E +G++ IN +
Sbjct: 784 ILHSSSNEDKTEFSGTIHDINSSL 807
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 112 bits (280), Expect = 2e-24
Identities = 103/395 (26%), Positives = 172/395 (43%), Gaps = 69/395 (17%)
Query: 726 DVFLRKQESGFGFRVLGGD-----GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIP 780
++ L + SG GF + GG G D I+I IIP GAA +DGRLR D ++ ++ +
Sbjct: 47 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 106
Query: 781 VKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEV 840
V SH + ++ + A V L VRR+
Sbjct: 107 VSEVSHSKAVEALKEAG--SIVRLYVRRR------------------------------- 133
Query: 841 PARPAPQEPYDVVLQRKENEGFGFVILTSK-NKPPPGVIPHKIGRVIEGSPADRCGKLKV 899
RP + ++ L K +G GF I N+ PG + ++I+G A + G+L+V
Sbjct: 134 --RPILETVVEIKLF-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQV 190
Query: 900 GDHISAVNGQSIVELSHDNIVQLIKDAGVTVTL-----TVIAEEEHHGPPSGTNSARQSP 954
GD + VN S+ E++H+ V ++K+ V L T I + +GPP T+S SP
Sbjct: 191 GDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHS--YSP 248
Query: 955 ALQHRPMGQSQAN---------HIPGDRSALEGE--IGKDVSTSYRHSWSDHKHLAQPDT 1003
+++ + + PG S + + D ++ +HS + QP
Sbjct: 249 PMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATR----QPSM 304
Query: 1004 AVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIH 1063
+ V V L +G G GF++ GG++ G+F+ + GPA G +
Sbjct: 305 TLQRAVSLEGEPR----KVVLHKGSTGLGFNIVGGED-GEGIFVSFILAGGPADLSGELQ 359
Query: 1064 VGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLL 1098
GDQI+ +NG +G +H +A ++ G V ++
Sbjct: 360 RGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 394
Score = 74.3 bits (181), Expect = 6e-13
Identities = 81/361 (22%), Positives = 147/361 (40%), Gaps = 78/361 (21%)
Query: 725 LDVFLRKQESGFGFRVLGGDGP-----DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGI 779
+++ L K G GF + GG G D SIY+ II GAA+KDGRL+ D L+ ++
Sbjct: 141 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 200
Query: 780 PVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAF--------ISTQNG 831
++ +H++ + ++ + ++ + I+ + D + ++ +S NG
Sbjct: 201 SLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNG 260
Query: 832 SPRLNRAEVPARPAPQEPY-----------------------DVVLQR------------ 856
+ + P P P + LQR
Sbjct: 261 TLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVV 320
Query: 857 --KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVEL 914
K + G GF I+ ++ G+ + ++ G PAD G+L+ GD I +VNG +
Sbjct: 321 LHKGSTGLGFNIVGGEDGE--GIF---VSFILAGGPADLSGELQRGDQILSVNGIDLRGA 375
Query: 915 SHDNIVQLIKDAGVTVTLTVIAEEE-----------------HHGPPSGTNSAR--QSPA 955
SH+ +K AG TVT+ + E +H SG+ S R Q +
Sbjct: 376 SHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRS 435
Query: 956 LQHRPM---GQSQANHIPGDRSALE-GEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGS 1011
L R M +S+ + +P + + G+I ++ S W + + + D+ + V+ S
Sbjct: 436 LYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPS 495
Query: 1012 R 1012
+
Sbjct: 496 K 496
Score = 67.8 bits (164), Expect = 6e-11
Identities = 69/272 (25%), Positives = 114/272 (41%), Gaps = 38/272 (13%)
Query: 576 LVTIPLIKGPKGFGFAIADSPTGQK--------VKMILDSQWCQG---LQKGDIIKEIYH 624
+V I L KGPKG GF+IA Q V I+D Q LQ GD + + +
Sbjct: 140 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 199
Query: 625 QNVQNLTHLQVVEVLKQ------FPVGADVPLLILRG-GPPSPTKTAKMKTDK---KENA 674
+++ +TH + V +LK VG + + GPP T + + N
Sbjct: 200 YSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 259
Query: 675 GSLEAINEPIP----QPMPFPPSIIRSG---SPKLDPSEVYLKSKTLYEDKPPNTKDLDV 727
G+LE P + P P ++ S + S TL + V
Sbjct: 260 GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKV 319
Query: 728 FLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHK 787
L K +G GF ++GG+ + I++ I+ G A+ G L+ D+++ ++GI ++G SH+
Sbjct: 320 VLHKGSTGLGFNIVGGED-GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 378
Query: 788 QVLDLMTTAARNGHVLLTVRRKIFYGEKQPED 819
Q + A + ++ + QPED
Sbjct: 379 QAAAALKGAGQTVTII---------AQYQPED 401
Score = 58.2 bits (139), Expect = 4e-08
Identities = 29/84 (34%), Positives = 49/84 (58%), Gaps = 5/84 (5%)
Query: 1022 VELERGPRGFGFSLRGGKEY-----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
+ LERG G GFS+ GG + + G+FI ++ G A +DGR+ V D I+ +N
Sbjct: 48 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
Query: 1077 QGITHTRAIELIQAGGNKVLLLLR 1100
++H++A+E ++ G+ V L +R
Sbjct: 108 SEVSHSKAVEALKEAGSIVRLYVR 131
Score = 55.1 bits (131), Expect = 4e-07
Identities = 32/110 (29%), Positives = 61/110 (55%), Gaps = 6/110 (5%)
Query: 1022 VELERGPRGFGFSLRG--GKEYNMG---LFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
++L +GP+G GFS+ G G ++ G +++ ++ + G A KDGR+ VGD+++ +N
Sbjct: 143 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 202
Query: 1077 QGITHTRAIELIQAGGNKVLLLL-RPGTGLIPDHGLAPSGLCSYVKPEQH 1125
+ +TH A+ +++ V L + +P T + D P SY P ++
Sbjct: 203 EEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMEN 252
Score = 47.4 bits (111), Expect = 8e-05
Identities = 37/129 (28%), Positives = 53/129 (41%), Gaps = 7/129 (5%)
Query: 850 YDVVLQRKENEGFGFVILTSKNKP----PPGVIPHKIGRVIEGSPADRCGKLKVGDHISA 905
++ + + N G GF I + P PG+ I ++I G A G+L+V D I
Sbjct: 45 FEEITLERGNSGLGFSIAGGTDNPHIGDDPGIF---ITKIIPGGAAAEDGRLRVNDCILR 101
Query: 906 VNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQ 965
VN + E+SH V+ +K+AG V L V + L G
Sbjct: 102 VNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVG 161
Query: 966 ANHIPGDRS 974
HIPGD S
Sbjct: 162 NQHIPGDNS 170
Score = 43.9 bits (102), Expect = 9e-04
Identities = 29/85 (34%), Positives = 43/85 (50%), Gaps = 8/85 (9%)
Query: 393 EKSHFTRDPSQ-------LKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPA 445
+ S TR PS L+G + L K + G GF I+GG+ E + V +L GPA
Sbjct: 294 QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGE-DGEGIFVSFILAGGPA 352
Query: 446 AQDGKIAPGDVIVDINGNCVLGHTH 470
G++ GD I+ +NG + G +H
Sbjct: 353 DLSGELQRGDQILSVNGIDLRGASH 377
Score = 43.5 bits (101), Expect = 0.001
Identities = 58/254 (22%), Positives = 98/254 (38%), Gaps = 29/254 (11%)
Query: 408 LVRASLKKSTMGFGFTIIGGDRP-----DEFLQVKNVLKDGPAAQDGKIAPGDVIVDING 462
+V L K G GF+I GG D + V ++ G A +DG++ GD ++ +N
Sbjct: 140 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 199
Query: 463 NCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVIN-----GQ 517
+ TH + V + + Y+ + + D P + + P+ N
Sbjct: 200 YSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 259
Query: 518 SLTKGETCMNPQDFKPGAM------VLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGS 571
+ +T + P PG +L + + H+ PS ++ VS+
Sbjct: 260 GTLEYKTSLPP--ISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSL----E 313
Query: 572 SQPELVTIPLIKGPKGFGFAIADSPTGQK--VKMIL---DSQWCQGLQKGDIIKEIYHQN 626
+P V L KG G GF I G+ V IL + LQ+GD I + +
Sbjct: 314 GEPRKVV--LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 371
Query: 627 VQNLTHLQVVEVLK 640
++ +H Q LK
Sbjct: 372 LRGASHEQAAAALK 385
Score = 42.4 bits (98), Expect = 0.003
Identities = 23/49 (46%), Positives = 30/49 (61%), Gaps = 1/49 (2%)
Query: 143 IPCTTRAPRDGEVPGVDYNF-ISVEQFKALEESGALLESGTYDGNFYGT 190
+P TTR RD EV G DY+F IS EQ + + +E+G Y+ N YGT
Sbjct: 588 VPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGT 636
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 107 bits (266), Expect = 8e-23
Identities = 107/434 (24%), Positives = 180/434 (41%), Gaps = 93/434 (21%)
Query: 687 PMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLD-----VFLRKQESGFGFRVL 741
P+P ++I P+ +P V + + +L N D D + L + SG GF +
Sbjct: 180 PVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIA 239
Query: 742 GGD-----GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTA 796
GG G D SI+I II GAA +DGRLR D ++ ++ + V+ +H + ++ + A
Sbjct: 240 GGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA 299
Query: 797 ARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQR 856
V L V+R+ +P ++ ++ L
Sbjct: 300 --GSIVRLYVKRR---------------------------------KPVSEKIMEIKL-I 323
Query: 857 KENEGFGFVILTS-KNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELS 915
K +G GF I N+ PG + ++IEG A + GKL++GD + AVN + E++
Sbjct: 324 KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVT 383
Query: 916 HDNIVQLIKDAGVTVTL-----TVIAEEEHHGPPSGTNSARQ------SPALQHRPMGQS 964
H+ V +K+ V L T + + + PP TNS+ Q SP+ S
Sbjct: 384 HEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPAS 443
Query: 965 QANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL 1024
A + P ++ L D + +P V L
Sbjct: 444 PARYSPVSKAVL----------------GDDEITREPRKVV------------------L 469
Query: 1025 ERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRA 1084
RG G GF++ GG++ G+FI + GPA G + GD+I+ +N + +H +A
Sbjct: 470 HRGSTGLGFNIVGGED-GEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQA 528
Query: 1085 IELIQAGGNKVLLL 1098
++ G V ++
Sbjct: 529 AAALKNAGQAVTIV 542
Score = 85.9 bits (211), Expect = 2e-16
Identities = 67/246 (27%), Positives = 114/246 (46%), Gaps = 28/246 (11%)
Query: 718 KPPNTKDLDVFLRKQESGFGFRVLGGDGP-----DQSIYIGAIIPLGAAEKDGRLRAADE 772
KP + K +++ L K G GF + GG G D SIY+ II GAA KDG+L+ D+
Sbjct: 311 KPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDK 370
Query: 773 LMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFY--GEKQPEDDSSQAFISTQN 830
L+ ++ + ++ +H++ + + + ++ + ++ G P+ +S + +
Sbjct: 371 LLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNH 430
Query: 831 GSPRLNRAEVPARPA---------------PQEPYDVVLQRKENEGFGFVILTSKNKPPP 875
SP + PA PA +EP VVL R G GF I+ ++
Sbjct: 431 VSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGST-GLGFNIVGGEDGE-- 487
Query: 876 GVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVI 935
G+ I ++ G PAD G+L+ GD I +VN + SH+ +K+AG VT+
Sbjct: 488 GIF---ISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQ 544
Query: 936 AEEEHH 941
E +
Sbjct: 545 YRPEEY 550
Score = 63.2 bits (152), Expect = 1e-09
Identities = 56/235 (23%), Positives = 102/235 (43%), Gaps = 24/235 (10%)
Query: 575 ELVTIPLIKGPKGFGFAIADSPTGQKV---KMILDSQWCQG--------LQKGDIIKEIY 623
+++ I LIKGPKG GF+IA Q + I ++ +G LQ GD + +
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 624 HQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEP 683
+ ++ +TH + V LK + L+ P T+ D + ++P
Sbjct: 376 NVCLEEVTHEEAVTALKN-----TSDFVYLKVAKP----TSMYMNDGYAPPDITNSSSQP 426
Query: 684 IPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGG 743
+ + P S + G P+ SK + D + V L + +G GF ++GG
Sbjct: 427 VDNHVS-PSSFL--GQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGG 483
Query: 744 DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAAR 798
+ + I+I I+ G A+ G LR D ++ ++ + ++ SH+Q + A +
Sbjct: 484 E-DGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQ 537
Score = 57.4 bits (137), Expect = 8e-08
Identities = 28/84 (33%), Positives = 49/84 (58%), Gaps = 5/84 (5%)
Query: 1022 VELERGPRGFGFSLRGGKEY-----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
+ LERG G GFS+ GG + + +FI ++ G A +DGR+ V D I+ +N
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
Query: 1077 QGITHTRAIELIQAGGNKVLLLLR 1100
+ +TH++A+E ++ G+ V L ++
Sbjct: 285 RDVTHSKAVEALKEAGSIVRLYVK 308
Score = 57.0 bits (136), Expect = 1e-07
Identities = 28/97 (28%), Positives = 56/97 (57%), Gaps = 5/97 (5%)
Query: 1022 VELERGPRGFGFSLRGG--KEYNMG---LFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
++L +GP+G GFS+ GG ++ G +++ ++ E G A KDG++ +GD+++ +N
Sbjct: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCL 379
Query: 1077 QGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGLAP 1113
+ +TH A+ ++ + V L + T + + G AP
Sbjct: 380 EEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP 416
Score = 45.1 bits (105), Expect = 4e-04
Identities = 63/284 (22%), Positives = 104/284 (36%), Gaps = 57/284 (20%)
Query: 371 VEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRP 430
VE K + ++ + KP EK ++ L K G GF+I GG
Sbjct: 293 VEALKEAGSIVRLYVKRRKPVSEK-------------IMEIKLIKGPKGLGFSIAGGVGN 339
Query: 431 -----DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQY 485
D + V +++ G A +DGK+ GD ++ +N C+ TH + V + Y
Sbjct: 340 QHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVY 399
Query: 486 VNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTK--GETCMNPQDFKPGAMVLEQNGK 543
+ + + D P + ++ PV N S + G+T +P + P
Sbjct: 400 LKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSP---------- 449
Query: 544 SGHTLTGDGLNGPSDASEQRVSMASSGSSQ--PELVTIPLIKGPKGFGFAIADSPTGQK- 600
VS A G + E + L +G G GF I G+
Sbjct: 450 --------------------VSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGI 489
Query: 601 -VKMIL---DSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLK 640
+ IL + L+KGD I + +++ +H Q LK
Sbjct: 490 FISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533
Score = 40.4 bits (93), Expect = 0.010
Identities = 21/49 (42%), Positives = 30/49 (61%), Gaps = 1/49 (2%)
Query: 143 IPCTTRAPRDGEVPGVDYNFI-SVEQFKALEESGALLESGTYDGNFYGT 190
+P TTR RD EV G DY+F+ S EQ + + +E+G Y+ + YGT
Sbjct: 743 VPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGT 791
Score = 40.0 bits (92), Expect = 0.012
Identities = 23/69 (33%), Positives = 37/69 (53%), Gaps = 5/69 (7%)
Query: 412 SLKKSTMGFGFTIIGG-DRP----DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVL 466
+L++ G GF+I GG D P D + + ++ G AAQDG++ D I+ +N V
Sbjct: 226 TLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVR 285
Query: 467 GHTHADVVQ 475
TH+ V+
Sbjct: 286 DVTHSKAVE 294
Score = 30.4 bits (67), Expect = 9.9
Identities = 28/96 (29%), Positives = 42/96 (43%), Gaps = 13/96 (13%)
Query: 575 ELVTIPLIKGPKGFGFAIADSPTGQKV---------KMILDSQWCQG--LQKGDIIKEIY 623
E I L +G G GF+IA + K+I Q L+ D I +
Sbjct: 221 EYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVN 280
Query: 624 HQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS 659
+V+++TH + VE LK+ G+ V L + R P S
Sbjct: 281 EVDVRDVTHSKAVEALKE--AGSIVRLYVKRRKPVS 314
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 107 bits (266), Expect = 8e-23
Identities = 107/434 (24%), Positives = 180/434 (41%), Gaps = 93/434 (21%)
Query: 687 PMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLD-----VFLRKQESGFGFRVL 741
P+P ++I P+ +P V + + +L N D D + L + SG GF +
Sbjct: 180 PVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIA 239
Query: 742 GGD-----GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTA 796
GG G D SI+I II GAA +DGRLR D ++ ++ + V+ +H + ++ + A
Sbjct: 240 GGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA 299
Query: 797 ARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQR 856
V L V+R+ +P ++ ++ L
Sbjct: 300 --GSIVRLYVKRR---------------------------------KPVSEKIMEIKL-I 323
Query: 857 KENEGFGFVILTS-KNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELS 915
K +G GF I N+ PG + ++IEG A + GKL++GD + AVN + E++
Sbjct: 324 KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVT 383
Query: 916 HDNIVQLIKDAGVTVTL-----TVIAEEEHHGPPSGTNSARQ------SPALQHRPMGQS 964
H+ V +K+ V L T + + + PP TNS+ Q SP+ S
Sbjct: 384 HEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPAS 443
Query: 965 QANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL 1024
A + P ++ L D + +P V L
Sbjct: 444 PARYSPVSKAVL----------------GDDEITREPRKVV------------------L 469
Query: 1025 ERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRA 1084
RG G GF++ GG++ G+FI + GPA G + GD+I+ +N + +H +A
Sbjct: 470 HRGSTGLGFNIVGGED-GEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQA 528
Query: 1085 IELIQAGGNKVLLL 1098
++ G V ++
Sbjct: 529 AAALKNAGQAVTIV 542
Score = 85.9 bits (211), Expect = 2e-16
Identities = 67/246 (27%), Positives = 114/246 (46%), Gaps = 28/246 (11%)
Query: 718 KPPNTKDLDVFLRKQESGFGFRVLGGDGP-----DQSIYIGAIIPLGAAEKDGRLRAADE 772
KP + K +++ L K G GF + GG G D SIY+ II GAA KDG+L+ D+
Sbjct: 311 KPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDK 370
Query: 773 LMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFY--GEKQPEDDSSQAFISTQN 830
L+ ++ + ++ +H++ + + + ++ + ++ G P+ +S + +
Sbjct: 371 LLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNH 430
Query: 831 GSPRLNRAEVPARPA---------------PQEPYDVVLQRKENEGFGFVILTSKNKPPP 875
SP + PA PA +EP VVL R G GF I+ ++
Sbjct: 431 VSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGST-GLGFNIVGGEDGE-- 487
Query: 876 GVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVI 935
G+ I ++ G PAD G+L+ GD I +VN + SH+ +K+AG VT+
Sbjct: 488 GIF---ISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQ 544
Query: 936 AEEEHH 941
E +
Sbjct: 545 YRPEEY 550
Score = 63.2 bits (152), Expect = 1e-09
Identities = 56/235 (23%), Positives = 102/235 (43%), Gaps = 24/235 (10%)
Query: 575 ELVTIPLIKGPKGFGFAIADSPTGQKV---KMILDSQWCQG--------LQKGDIIKEIY 623
+++ I LIKGPKG GF+IA Q + I ++ +G LQ GD + +
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 624 HQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEP 683
+ ++ +TH + V LK + L+ P T+ D + ++P
Sbjct: 376 NVCLEEVTHEEAVTALKN-----TSDFVYLKVAKP----TSMYMNDGYAPPDITNSSSQP 426
Query: 684 IPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGG 743
+ + P S + G P+ SK + D + V L + +G GF ++GG
Sbjct: 427 VDNHVS-PSSFL--GQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGG 483
Query: 744 DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAAR 798
+ + I+I I+ G A+ G LR D ++ ++ + ++ SH+Q + A +
Sbjct: 484 E-DGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQ 537
Score = 57.4 bits (137), Expect = 8e-08
Identities = 28/84 (33%), Positives = 49/84 (58%), Gaps = 5/84 (5%)
Query: 1022 VELERGPRGFGFSLRGGKEY-----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
+ LERG G GFS+ GG + + +FI ++ G A +DGR+ V D I+ +N
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
Query: 1077 QGITHTRAIELIQAGGNKVLLLLR 1100
+ +TH++A+E ++ G+ V L ++
Sbjct: 285 RDVTHSKAVEALKEAGSIVRLYVK 308
Score = 57.0 bits (136), Expect = 1e-07
Identities = 28/97 (28%), Positives = 56/97 (57%), Gaps = 5/97 (5%)
Query: 1022 VELERGPRGFGFSLRGG--KEYNMG---LFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
++L +GP+G GFS+ GG ++ G +++ ++ E G A KDG++ +GD+++ +N
Sbjct: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCL 379
Query: 1077 QGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGLAP 1113
+ +TH A+ ++ + V L + T + + G AP
Sbjct: 380 EEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP 416
Score = 45.1 bits (105), Expect = 4e-04
Identities = 63/284 (22%), Positives = 104/284 (36%), Gaps = 57/284 (20%)
Query: 371 VEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRP 430
VE K + ++ + KP EK ++ L K G GF+I GG
Sbjct: 293 VEALKEAGSIVRLYVKRRKPVSEK-------------IMEIKLIKGPKGLGFSIAGGVGN 339
Query: 431 -----DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQY 485
D + V +++ G A +DGK+ GD ++ +N C+ TH + V + Y
Sbjct: 340 QHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVY 399
Query: 486 VNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTK--GETCMNPQDFKPGAMVLEQNGK 543
+ + + D P + ++ PV N S + G+T +P + P
Sbjct: 400 LKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSP---------- 449
Query: 544 SGHTLTGDGLNGPSDASEQRVSMASSGSSQ--PELVTIPLIKGPKGFGFAIADSPTGQK- 600
VS A G + E + L +G G GF I G+
Sbjct: 450 --------------------VSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGI 489
Query: 601 -VKMIL---DSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLK 640
+ IL + L+KGD I + +++ +H Q LK
Sbjct: 490 FISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533
Score = 40.4 bits (93), Expect = 0.010
Identities = 21/49 (42%), Positives = 30/49 (61%), Gaps = 1/49 (2%)
Query: 143 IPCTTRAPRDGEVPGVDYNFI-SVEQFKALEESGALLESGTYDGNFYGT 190
+P TTR RD EV G DY+F+ S EQ + + +E+G Y+ + YGT
Sbjct: 765 VPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGT 813
Score = 40.0 bits (92), Expect = 0.012
Identities = 23/69 (33%), Positives = 37/69 (53%), Gaps = 5/69 (7%)
Query: 412 SLKKSTMGFGFTIIGG-DRP----DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVL 466
+L++ G GF+I GG D P D + + ++ G AAQDG++ D I+ +N V
Sbjct: 226 TLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVR 285
Query: 467 GHTHADVVQ 475
TH+ V+
Sbjct: 286 DVTHSKAVE 294
Score = 30.4 bits (67), Expect = 9.9
Identities = 28/96 (29%), Positives = 42/96 (43%), Gaps = 13/96 (13%)
Query: 575 ELVTIPLIKGPKGFGFAIADSPTGQKV---------KMILDSQWCQG--LQKGDIIKEIY 623
E I L +G G GF+IA + K+I Q L+ D I +
Sbjct: 221 EYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVN 280
Query: 624 HQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS 659
+V+++TH + VE LK+ G+ V L + R P S
Sbjct: 281 EVDVRDVTHSKAVEALKE--AGSIVRLYVKRRKPVS 314
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 105 bits (261), Expect = 3e-22
Identities = 145/623 (23%), Positives = 238/623 (38%), Gaps = 92/623 (14%)
Query: 414 KKSTMGFGFTIIGGD---RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTH 470
K + G GF IIGG+ R D + + +V GPA DG + PGD ++ +N + G +H
Sbjct: 907 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 966
Query: 471 ADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQD 530
+++ Q P + +TL P S+ P +TPV + + M
Sbjct: 967 HAAIEILQNAPED----VTLVISQPKEKISKVP------STPV---HLTNEMKNYMKKSS 1013
Query: 531 FKPGAMVLEQNGKSGH----TLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPK 586
+ + + + + K H TL N + R SS S+ E ++ +
Sbjct: 1014 YMQDSAI-DSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNG 1072
Query: 587 GFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGA 646
F + D Q Q Q G + + + T + + P +
Sbjct: 1073 FFASHLGD-------------QTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGIS 1119
Query: 647 DVPLLILRGGPPSPTKTAKMKTD----KKENAGSLEAINEPIPQPMPFPPSIIRSGSPKL 702
DV RG T D K+E++ S+ N+
Sbjct: 1120 DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNK-------------------- 1159
Query: 703 DPSEVYLKSKTLYEDKPPNTKDL-DVFLRKQESGFGFRVLGGDGPDQ---SIYIGAIIPL 758
+ KT + PP D+ +V L K ++ G V GG IY+ A+IP
Sbjct: 1160 ------MNFKT-FSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQ 1212
Query: 759 GAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPE 818
GAAE DGR+ D ++ ++G+ ++G +HKQ ++ + + H+LL + E P
Sbjct: 1213 GAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPV 1272
Query: 819 DDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQR--------KENEGFGFVILTSK 870
+ Q +S QN + E + + Y V + K + G GF
Sbjct: 1273 --TPQCTLSDQNAQGQ--GPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSRED 1328
Query: 871 NKPPPGVIPH--KIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGV 928
N P + ++ ++ G PA GK+ VGD I VNG S+ LS ++ ++
Sbjct: 1329 NLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAP 1388
Query: 929 TVTLTVIAEEEHHGPPSGTN--SARQSPA--LQHRPMGQSQANHIPGDRSALEGEIG--- 981
V L + P T + QSPA L + SQ + + S+ E E+
Sbjct: 1389 EVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKS 1448
Query: 982 --KDVSTSYRHSWSDHKHLAQPD 1002
+ S S R S+SD + D
Sbjct: 1449 KKQCKSPSRRDSYSDSSGSGEDD 1471
Score = 80.5 bits (197), Expect = 8e-15
Identities = 86/387 (22%), Positives = 155/387 (40%), Gaps = 56/387 (14%)
Query: 735 GFGFRVLGGDGP---DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD 791
G GF+++GG+ D I+I ++ P G A+ DG L+ D L+ ++ + ++G SH ++
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 792 LMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYD 851
++ A PED ++ P+ ++VP+ P +
Sbjct: 972 ILQNA--------------------PED------VTLVISQPKEKISKVPSTPV-HLTNE 1004
Query: 852 VVLQRKENEGFGFVILTSKNKP---PPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNG 908
+ K++ + S +K G + H I + G L+ G S +
Sbjct: 1005 MKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRH-----ISENSFGPSGGLREGSLSSQDSR 1059
Query: 909 QSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANH 968
LS + T +E HG PS + ++ + QS+
Sbjct: 1060 TESASLSQSQVNGFFASHLGDQTW----QESQHGSPSPSVISKATEKETFTDSNQSKTKK 1115
Query: 969 IPG--DRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYP----- 1021
PG D + D+ + S DH+ Q ++ ++ + + P
Sbjct: 1116 -PGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGD 1174
Query: 1022 ---VELERGPRGFGFSLRGGKEYNM---GLFILRLAEDGPAIKDGRIHVGDQIVEINGEP 1075
VEL + G S+ GG ++ G+++ + G A DGRIH GD+++ +NG
Sbjct: 1175 IFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1234
Query: 1076 TQGITHTRAIELIQAGGNKVLLLLRPG 1102
+G TH +A+E ++ G V LLL G
Sbjct: 1235 LEGATHKQAVETLRNTGQVVHLLLEKG 1261
Score = 59.3 bits (142), Expect = 2e-08
Identities = 170/845 (20%), Positives = 304/845 (35%), Gaps = 154/845 (18%)
Query: 30 GAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLA 89
G +I GG + G LG G + G PGD L+ VN + G+++ +
Sbjct: 914 GFQIIGGEKMGRLD-LGIFISSVAPGGPADLDG-CLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 90 VIRHFREPIRLKTVKPGKVINK----------DLRHYL--SLQFQKGSIDHKLQQVIRDN 137
++++ E + L +P + I+K ++++Y+ S Q +ID +
Sbjct: 972 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSR 1031
Query: 138 LYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEES------GALLESGTYDGNFYGTP 191
LR I + P G G + S + +L +S + L T+ + +G+P
Sbjct: 1032 GTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSP 1091
Query: 192 KPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEEEDEDKEAINGS 251
P V + E +S + +T + D S + D D + S
Sbjct: 1092 SPS----------VISKATEKETFTDSNQSKTKKPGISDVTDYS---DRGDSDMDEATYS 1138
Query: 252 GNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNW---EMAYTDTGM 308
+ +++ ESS S T++ M+F+ + + P P + E+A D +
Sbjct: 1139 SSQDHQTPKQESS-------SSVNTSNKMNFKTF----SSSPPKPGDIFEVELAKNDNSL 1187
Query: 309 IYFIDHNTKTTTWLDPRLCKKAKAPEDC--EDGELPYG----------------WEKIED 350
+ T+ + KA P+ DG + G + +E
Sbjct: 1188 GISVTGGVNTSV-RHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1246
Query: 351 PQYGTYYVDHLNQKTQFENPVEEAKRKKQL---GQVEIGSSKPDMEKSHFTRDPSQL-KG 406
+ V L +K Q E Q Q G ++K+ +D S + +
Sbjct: 1247 LRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEE 1306
Query: 407 VLVRASLKKSTMGFGFTIIGGDR--PDEF----LQVKNVLKDGPAAQDGKIAPGDVIVDI 460
L K++ G GF+ D P++ ++VK + PAA+ GKI GDVI+ +
Sbjct: 1307 NTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKV 1366
Query: 461 NGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLT 520
NG + G + +V+ L V L LCR P P +D TP+ +
Sbjct: 1367 NGASLKGLSQQEVIS--ALRGTAPEVFLLLCR----PPPGVLPEIDTALLTPL-----QS 1415
Query: 521 KGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMA-SSGSSQPELVTI 579
+ N +EQ+ S D + +R S + SSGS + +LVT
Sbjct: 1416 PAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTA 1475
Query: 580 PLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVL 639
P I +S W L HQ + N+ + +
Sbjct: 1476 P---------------------ANISNSTWSSAL----------HQTLSNM--VSQAQSH 1502
Query: 640 KQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAIN-EPIPQPM----PFPPSI 694
+ P + + + P K N E N P+P M + P
Sbjct: 1503 HEAPKSQEDTICTMFYYP-----------QKIPNKPEFEDSNPSPLPPDMAPGQSYQPQS 1551
Query: 695 IRSGSPKLDPSEV-YLKSKTLYEDKPPNTKDLD--------------VFLRKQESGFGFR 739
+ S +D + ++ T E+ P DL+ ++ ++ GF
Sbjct: 1552 ESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFT 1611
Query: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARN 799
V G+ Y+ +I A+ DGRL+ D L+ ++ V +H ++L+ A++
Sbjct: 1612 VTKGN-QRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKT 1669
Query: 800 GHVLL 804
+++
Sbjct: 1670 VRLVI 1674
Score = 57.0 bits (136), Expect = 1e-07
Identities = 70/308 (22%), Positives = 130/308 (42%), Gaps = 51/308 (16%)
Query: 812 YGEKQPEDDSSQAFISTQNGSPRLN-RAEVPARPAPQEPYDVVLQRKENEGFGFVILTSK 870
Y Q Q S+ N S ++N + + P P + ++V L + +N G +
Sbjct: 1137 YSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNS-LGISVTGGV 1195
Query: 871 NKPPPGVIPHK---IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAG 927
N + H + VI A+ G++ GD + AVNG S+ +H V+ +++ G
Sbjct: 1196 NTS----VRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTG 1251
Query: 928 VTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTS 987
V L + E+ P S +H P+ D++A +G+ + V +
Sbjct: 1252 QVVHLLL---EKGQSPTSK----------EHVPVTPQCTL---SDQNA-QGQGPEKVKKT 1294
Query: 988 YRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGG-----KEYN 1042
+ D+ + + +T + V+L + G GFS ++ N
Sbjct: 1295 TQVK--DYSFVTEENT----------------FEVKLFKNSSGLGFSFSREDNLIPEQIN 1336
Query: 1043 MGLF-ILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL-R 1100
+ + +L PA + G+I VGD I+++NG +G++ I ++ +V LLL R
Sbjct: 1337 ASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1396
Query: 1101 PGTGLIPD 1108
P G++P+
Sbjct: 1397 PPPGVLPE 1404
Score = 44.7 bits (104), Expect = 5e-04
Identities = 70/288 (24%), Positives = 119/288 (41%), Gaps = 42/288 (14%)
Query: 221 KRTTSVSKMERMDSSLPEEEEDEDKEAINGSGNAENRERHSESS----DWMKTVPSY--N 274
K ++ S +E+ SS E D+ K+ + R+ +S+SS D + T P+ N
Sbjct: 1425 KDSSQPSCVEQSTSSDENEMSDKSKKQCK---SPSRRDSYSDSSGSGEDDLVTAPANISN 1481
Query: 275 QTNSS---MDFRNYMMRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAK 331
T SS N + + ++ PK+ E T M Y+ + D +
Sbjct: 1482 STWSSALHQTLSNMVSQAQSHHEAPKSQED--TICTMFYYPQKIPNKPEFEDSN---PSP 1536
Query: 332 APEDCEDGEL--PYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQVEIGSSK 389
P D G+ P E Y++ H+++ T+ EN K
Sbjct: 1537 LPPDMAPGQSYQPQS-ESASSSSMDKYHIHHISEPTRQENWTP---------------LK 1580
Query: 390 PDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDG 449
D+E +H + +L+ L+ +K GFT+ G++ V +V++D PA DG
Sbjct: 1581 NDLE-NHL--EDFELEVELLITLIKSEKGSLGFTVTKGNQRIG-CYVHDVIQD-PAKSDG 1635
Query: 450 KIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLP 497
++ PGD ++ +N V TH D V + L ++ V L + R LP
Sbjct: 1636 RLKPGDRLIKVNDTDVTNMTHTDAVNL--LRAASKTVRLVIGRVLELP 1681
Score = 44.3 bits (103), Expect = 7e-04
Identities = 23/78 (29%), Positives = 46/78 (58%), Gaps = 4/78 (5%)
Query: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
++ E+G GF++ G + +G ++ + +D PA DGR+ GD+++++N +TH
Sbjct: 1601 IKSEKG--SLGFTVTKGNQ-RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTH 1656
Query: 1082 TRAIELIQAGGNKVLLLL 1099
T A+ L++A V L++
Sbjct: 1657 TDAVNLLRAASKTVRLVI 1674
Score = 41.2 bits (95), Expect = 0.006
Identities = 28/90 (31%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 852 VVLQRKENEGFGFVILTSKN--KPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQ 909
V L++ G GF I+ + + G+ I V G PAD G LK GD + +VN
Sbjct: 903 VNLKKDAKYGLGFQIIGGEKMGRLDLGIF---ISSVAPGGPADLDGCLKPGDRLISVNSV 959
Query: 910 SIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
S+ +SH ++++++A VTL + +E
Sbjct: 960 SLEGVSHHAAIEILQNAPEDVTLVISQPKE 989
Score = 37.4 bits (85), Expect = 0.081
Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 6/83 (7%)
Query: 852 VVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSI 911
+ L + E GF + +K G H + + PA G+LK GD + VN +
Sbjct: 1598 ITLIKSEKGSLGFTV--TKGNQRIGCYVHDVIQ----DPAKSDGRLKPGDRLIKVNDTDV 1651
Query: 912 VELSHDNIVQLIKDAGVTVTLTV 934
++H + V L++ A TV L +
Sbjct: 1652 TNMTHTDAVNLLRAASKTVRLVI 1674
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 105 bits (261), Expect = 3e-22
Identities = 145/623 (23%), Positives = 238/623 (38%), Gaps = 92/623 (14%)
Query: 414 KKSTMGFGFTIIGGD---RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTH 470
K + G GF IIGG+ R D + + +V GPA DG + PGD ++ +N + G +H
Sbjct: 1098 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1157
Query: 471 ADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQD 530
+++ Q P + +TL P S+ P +TPV + + M
Sbjct: 1158 HAAIEILQNAPED----VTLVISQPKEKISKVP------STPV---HLTNEMKNYMKKSS 1204
Query: 531 FKPGAMVLEQNGKSGH----TLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPK 586
+ + + + + K H TL N + R SS S+ E ++ +
Sbjct: 1205 YMQDSAI-DSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNG 1263
Query: 587 GFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGA 646
F + D Q Q Q G + + + T + + P +
Sbjct: 1264 FFASHLGD-------------QTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGIS 1310
Query: 647 DVPLLILRGGPPSPTKTAKMKTD----KKENAGSLEAINEPIPQPMPFPPSIIRSGSPKL 702
DV RG T D K+E++ S+ N+
Sbjct: 1311 DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNK-------------------- 1350
Query: 703 DPSEVYLKSKTLYEDKPPNTKDL-DVFLRKQESGFGFRVLGGDGPDQ---SIYIGAIIPL 758
+ KT + PP D+ +V L K ++ G V GG IY+ A+IP
Sbjct: 1351 ------MNFKT-FSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQ 1403
Query: 759 GAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPE 818
GAAE DGR+ D ++ ++G+ ++G +HKQ ++ + + H+LL + E P
Sbjct: 1404 GAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPV 1463
Query: 819 DDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQR--------KENEGFGFVILTSK 870
+ Q +S QN + E + + Y V + K + G GF
Sbjct: 1464 --TPQCTLSDQNAQGQ--GPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSRED 1519
Query: 871 NKPPPGVIPH--KIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGV 928
N P + ++ ++ G PA GK+ VGD I VNG S+ LS ++ ++
Sbjct: 1520 NLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAP 1579
Query: 929 TVTLTVIAEEEHHGPPSGTN--SARQSPA--LQHRPMGQSQANHIPGDRSALEGEIG--- 981
V L + P T + QSPA L + SQ + + S+ E E+
Sbjct: 1580 EVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKS 1639
Query: 982 --KDVSTSYRHSWSDHKHLAQPD 1002
+ S S R S+SD + D
Sbjct: 1640 KKQCKSPSRRDSYSDSSGSGEDD 1662
Score = 80.5 bits (197), Expect = 8e-15
Identities = 86/387 (22%), Positives = 155/387 (40%), Gaps = 56/387 (14%)
Query: 735 GFGFRVLGGDGP---DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD 791
G GF+++GG+ D I+I ++ P G A+ DG L+ D L+ ++ + ++G SH ++
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 792 LMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYD 851
++ A PED ++ P+ ++VP+ P +
Sbjct: 1163 ILQNA--------------------PED------VTLVISQPKEKISKVPSTPV-HLTNE 1195
Query: 852 VVLQRKENEGFGFVILTSKNKP---PPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNG 908
+ K++ + S +K G + H I + G L+ G S +
Sbjct: 1196 MKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRH-----ISENSFGPSGGLREGSLSSQDSR 1250
Query: 909 QSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANH 968
LS + T +E HG PS + ++ + QS+
Sbjct: 1251 TESASLSQSQVNGFFASHLGDQTW----QESQHGSPSPSVISKATEKETFTDSNQSKTKK 1306
Query: 969 IPG--DRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYP----- 1021
PG D + D+ + S DH+ Q ++ ++ + + P
Sbjct: 1307 -PGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGD 1365
Query: 1022 ---VELERGPRGFGFSLRGGKEYNM---GLFILRLAEDGPAIKDGRIHVGDQIVEINGEP 1075
VEL + G S+ GG ++ G+++ + G A DGRIH GD+++ +NG
Sbjct: 1366 IFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1425
Query: 1076 TQGITHTRAIELIQAGGNKVLLLLRPG 1102
+G TH +A+E ++ G V LLL G
Sbjct: 1426 LEGATHKQAVETLRNTGQVVHLLLEKG 1452
Score = 59.3 bits (142), Expect = 2e-08
Identities = 170/845 (20%), Positives = 304/845 (35%), Gaps = 154/845 (18%)
Query: 30 GAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLA 89
G +I GG + G LG G + G PGD L+ VN + G+++ +
Sbjct: 1105 GFQIIGGEKMGRLD-LGIFISSVAPGGPADLDG-CLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 90 VIRHFREPIRLKTVKPGKVINK----------DLRHYL--SLQFQKGSIDHKLQQVIRDN 137
++++ E + L +P + I+K ++++Y+ S Q +ID +
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSR 1222
Query: 138 LYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEES------GALLESGTYDGNFYGTP 191
LR I + P G G + S + +L +S + L T+ + +G+P
Sbjct: 1223 GTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSP 1282
Query: 192 KPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEEEDEDKEAINGS 251
P V + E +S + +T + D S + D D + S
Sbjct: 1283 SPS----------VISKATEKETFTDSNQSKTKKPGISDVTDYS---DRGDSDMDEATYS 1329
Query: 252 GNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNW---EMAYTDTGM 308
+ +++ ESS S T++ M+F+ + + P P + E+A D +
Sbjct: 1330 SSQDHQTPKQESS-------SSVNTSNKMNFKTF----SSSPPKPGDIFEVELAKNDNSL 1378
Query: 309 IYFIDHNTKTTTWLDPRLCKKAKAPEDC--EDGELPYG----------------WEKIED 350
+ T+ + KA P+ DG + G + +E
Sbjct: 1379 GISVTGGVNTSV-RHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1437
Query: 351 PQYGTYYVDHLNQKTQFENPVEEAKRKKQL---GQVEIGSSKPDMEKSHFTRDPSQL-KG 406
+ V L +K Q E Q Q G ++K+ +D S + +
Sbjct: 1438 LRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEE 1497
Query: 407 VLVRASLKKSTMGFGFTIIGGDR--PDEF----LQVKNVLKDGPAAQDGKIAPGDVIVDI 460
L K++ G GF+ D P++ ++VK + PAA+ GKI GDVI+ +
Sbjct: 1498 NTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKV 1557
Query: 461 NGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLT 520
NG + G + +V+ L V L LCR P P +D TP+ +
Sbjct: 1558 NGASLKGLSQQEVIS--ALRGTAPEVFLLLCR----PPPGVLPEIDTALLTPL-----QS 1606
Query: 521 KGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMA-SSGSSQPELVTI 579
+ N +EQ+ S D + +R S + SSGS + +LVT
Sbjct: 1607 PAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTA 1666
Query: 580 PLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVL 639
P I +S W L HQ + N+ + +
Sbjct: 1667 P---------------------ANISNSTWSSAL----------HQTLSNM--VSQAQSH 1693
Query: 640 KQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAIN-EPIPQPM----PFPPSI 694
+ P + + + P K N E N P+P M + P
Sbjct: 1694 HEAPKSQEDTICTMFYYP-----------QKIPNKPEFEDSNPSPLPPDMAPGQSYQPQS 1742
Query: 695 IRSGSPKLDPSEV-YLKSKTLYEDKPPNTKDLD--------------VFLRKQESGFGFR 739
+ S +D + ++ T E+ P DL+ ++ ++ GF
Sbjct: 1743 ESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFT 1802
Query: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARN 799
V G+ Y+ +I A+ DGRL+ D L+ ++ V +H ++L+ A++
Sbjct: 1803 VTKGN-QRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKT 1860
Query: 800 GHVLL 804
+++
Sbjct: 1861 VRLVI 1865
Score = 57.0 bits (136), Expect = 1e-07
Identities = 70/308 (22%), Positives = 130/308 (42%), Gaps = 51/308 (16%)
Query: 812 YGEKQPEDDSSQAFISTQNGSPRLN-RAEVPARPAPQEPYDVVLQRKENEGFGFVILTSK 870
Y Q Q S+ N S ++N + + P P + ++V L + +N G +
Sbjct: 1328 YSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNS-LGISVTGGV 1386
Query: 871 NKPPPGVIPHK---IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAG 927
N + H + VI A+ G++ GD + AVNG S+ +H V+ +++ G
Sbjct: 1387 NTS----VRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTG 1442
Query: 928 VTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTS 987
V L + E+ P S +H P+ D++A +G+ + V +
Sbjct: 1443 QVVHLLL---EKGQSPTSK----------EHVPVTPQCTL---SDQNA-QGQGPEKVKKT 1485
Query: 988 YRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGG-----KEYN 1042
+ D+ + + +T + V+L + G GFS ++ N
Sbjct: 1486 TQVK--DYSFVTEENT----------------FEVKLFKNSSGLGFSFSREDNLIPEQIN 1527
Query: 1043 MGLF-ILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL-R 1100
+ + +L PA + G+I VGD I+++NG +G++ I ++ +V LLL R
Sbjct: 1528 ASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1587
Query: 1101 PGTGLIPD 1108
P G++P+
Sbjct: 1588 PPPGVLPE 1595
Score = 44.7 bits (104), Expect = 5e-04
Identities = 70/288 (24%), Positives = 119/288 (41%), Gaps = 42/288 (14%)
Query: 221 KRTTSVSKMERMDSSLPEEEEDEDKEAINGSGNAENRERHSESS----DWMKTVPSY--N 274
K ++ S +E+ SS E D+ K+ + R+ +S+SS D + T P+ N
Sbjct: 1616 KDSSQPSCVEQSTSSDENEMSDKSKKQCK---SPSRRDSYSDSSGSGEDDLVTAPANISN 1672
Query: 275 QTNSS---MDFRNYMMRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAK 331
T SS N + + ++ PK+ E T M Y+ + D +
Sbjct: 1673 STWSSALHQTLSNMVSQAQSHHEAPKSQED--TICTMFYYPQKIPNKPEFEDSN---PSP 1727
Query: 332 APEDCEDGEL--PYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQVEIGSSK 389
P D G+ P E Y++ H+++ T+ EN K
Sbjct: 1728 LPPDMAPGQSYQPQS-ESASSSSMDKYHIHHISEPTRQENWTP---------------LK 1771
Query: 390 PDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDG 449
D+E +H + +L+ L+ +K GFT+ G++ V +V++D PA DG
Sbjct: 1772 NDLE-NHL--EDFELEVELLITLIKSEKGSLGFTVTKGNQRIG-CYVHDVIQD-PAKSDG 1826
Query: 450 KIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLP 497
++ PGD ++ +N V TH D V + L ++ V L + R LP
Sbjct: 1827 RLKPGDRLIKVNDTDVTNMTHTDAVNL--LRAASKTVRLVIGRVLELP 1872
Score = 44.3 bits (103), Expect = 7e-04
Identities = 23/78 (29%), Positives = 46/78 (58%), Gaps = 4/78 (5%)
Query: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
++ E+G GF++ G + +G ++ + +D PA DGR+ GD+++++N +TH
Sbjct: 1792 IKSEKG--SLGFTVTKGNQ-RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTH 1847
Query: 1082 TRAIELIQAGGNKVLLLL 1099
T A+ L++A V L++
Sbjct: 1848 TDAVNLLRAASKTVRLVI 1865
Score = 41.2 bits (95), Expect = 0.006
Identities = 28/90 (31%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 852 VVLQRKENEGFGFVILTSKN--KPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQ 909
V L++ G GF I+ + + G+ I V G PAD G LK GD + +VN
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIF---ISSVAPGGPADLDGCLKPGDRLISVNSV 1150
Query: 910 SIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
S+ +SH ++++++A VTL + +E
Sbjct: 1151 SLEGVSHHAAIEILQNAPEDVTLVISQPKE 1180
Score = 37.4 bits (85), Expect = 0.081
Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 6/83 (7%)
Query: 852 VVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSI 911
+ L + E GF + +K G H + + PA G+LK GD + VN +
Sbjct: 1789 ITLIKSEKGSLGFTV--TKGNQRIGCYVHDVIQ----DPAKSDGRLKPGDRLIKVNDTDV 1842
Query: 912 VELSHDNIVQLIKDAGVTVTLTV 934
++H + V L++ A TV L +
Sbjct: 1843 TNMTHTDAVNLLRAASKTVRLVI 1865
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 105 bits (261), Expect = 3e-22
Identities = 145/623 (23%), Positives = 238/623 (38%), Gaps = 92/623 (14%)
Query: 414 KKSTMGFGFTIIGGD---RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTH 470
K + G GF IIGG+ R D + + +V GPA DG + PGD ++ +N + G +H
Sbjct: 1079 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1138
Query: 471 ADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQD 530
+++ Q P + +TL P S+ P +TPV + + M
Sbjct: 1139 HAAIEILQNAPED----VTLVISQPKEKISKVP------STPV---HLTNEMKNYMKKSS 1185
Query: 531 FKPGAMVLEQNGKSGH----TLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPK 586
+ + + + + K H TL N + R SS S+ E ++ +
Sbjct: 1186 YMQDSAI-DSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNG 1244
Query: 587 GFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGA 646
F + D Q Q Q G + + + T + + P +
Sbjct: 1245 FFASHLGD-------------QTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGIS 1291
Query: 647 DVPLLILRGGPPSPTKTAKMKTD----KKENAGSLEAINEPIPQPMPFPPSIIRSGSPKL 702
DV RG T D K+E++ S+ N+
Sbjct: 1292 DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNK-------------------- 1331
Query: 703 DPSEVYLKSKTLYEDKPPNTKDL-DVFLRKQESGFGFRVLGGDGPDQ---SIYIGAIIPL 758
+ KT + PP D+ +V L K ++ G V GG IY+ A+IP
Sbjct: 1332 ------MNFKT-FSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQ 1384
Query: 759 GAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPE 818
GAAE DGR+ D ++ ++G+ ++G +HKQ ++ + + H+LL + E P
Sbjct: 1385 GAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPV 1444
Query: 819 DDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQR--------KENEGFGFVILTSK 870
+ Q +S QN + E + + Y V + K + G GF
Sbjct: 1445 --TPQCTLSDQNAQGQ--GPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSRED 1500
Query: 871 NKPPPGVIPH--KIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGV 928
N P + ++ ++ G PA GK+ VGD I VNG S+ LS ++ ++
Sbjct: 1501 NLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAP 1560
Query: 929 TVTLTVIAEEEHHGPPSGTN--SARQSPA--LQHRPMGQSQANHIPGDRSALEGEIG--- 981
V L + P T + QSPA L + SQ + + S+ E E+
Sbjct: 1561 EVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKS 1620
Query: 982 --KDVSTSYRHSWSDHKHLAQPD 1002
+ S S R S+SD + D
Sbjct: 1621 KKQCKSPSRRDSYSDSSGSGEDD 1643
Score = 80.9 bits (198), Expect = 6e-15
Identities = 92/423 (21%), Positives = 165/423 (39%), Gaps = 60/423 (14%)
Query: 703 DPSEVY----LKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGP---DQSIYIGAI 755
DP + Y L + P L + + G GF+++GG+ D I+I ++
Sbjct: 1048 DPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSV 1107
Query: 756 IPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEK 815
P G A+ DG L+ D L+ ++ + ++G SH ++++ A
Sbjct: 1108 APGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNA------------------- 1148
Query: 816 QPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKP-- 873
PED ++ P+ ++VP+ P ++ K++ + S +K
Sbjct: 1149 -PED------VTLVISQPKEKISKVPSTPV-HLTNEMKNYMKKSSYMQDSAIDSSSKDHH 1200
Query: 874 -PPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTL 932
G + H I + G L+ G S + LS + T
Sbjct: 1201 WSRGTLRH-----ISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTW 1255
Query: 933 TVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPG--DRSALEGEIGKDVSTSYRH 990
+E HG PS + ++ + QS+ PG D + D+ +
Sbjct: 1256 ----QESQHGSPSPSVISKATEKETFTDSNQSKTKK-PGISDVTDYSDRGDSDMDEATYS 1310
Query: 991 SWSDHKHLAQPDTAVISVVGSRHNQNLGCYP--------VELERGPRGFGFSLRGGKEYN 1042
S DH+ Q ++ ++ + + P VEL + G S+ GG +
Sbjct: 1311 SSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTS 1370
Query: 1043 M---GLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
+ G+++ + G A DGRIH GD+++ +NG +G TH +A+E ++ G V LLL
Sbjct: 1371 VRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1430
Query: 1100 RPG 1102
G
Sbjct: 1431 EKG 1433
Score = 59.3 bits (142), Expect = 2e-08
Identities = 170/845 (20%), Positives = 304/845 (35%), Gaps = 154/845 (18%)
Query: 30 GAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLA 89
G +I GG + G LG G + G PGD L+ VN + G+++ +
Sbjct: 1086 GFQIIGGEKMGRLD-LGIFISSVAPGGPADLDG-CLKPGDRLISVNSVSLEGVSHHAAIE 1143
Query: 90 VIRHFREPIRLKTVKPGKVINK----------DLRHYL--SLQFQKGSIDHKLQQVIRDN 137
++++ E + L +P + I+K ++++Y+ S Q +ID +
Sbjct: 1144 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSR 1203
Query: 138 LYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEES------GALLESGTYDGNFYGTP 191
LR I + P G G + S + +L +S + L T+ + +G+P
Sbjct: 1204 GTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSP 1263
Query: 192 KPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEEEDEDKEAINGS 251
P V + E +S + +T + D S + D D + S
Sbjct: 1264 SPS----------VISKATEKETFTDSNQSKTKKPGISDVTDYS---DRGDSDMDEATYS 1310
Query: 252 GNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNW---EMAYTDTGM 308
+ +++ ESS S T++ M+F+ + + P P + E+A D +
Sbjct: 1311 SSQDHQTPKQESS-------SSVNTSNKMNFKTF----SSSPPKPGDIFEVELAKNDNSL 1359
Query: 309 IYFIDHNTKTTTWLDPRLCKKAKAPEDC--EDGELPYG----------------WEKIED 350
+ T+ + KA P+ DG + G + +E
Sbjct: 1360 GISVTGGVNTSV-RHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1418
Query: 351 PQYGTYYVDHLNQKTQFENPVEEAKRKKQL---GQVEIGSSKPDMEKSHFTRDPSQL-KG 406
+ V L +K Q E Q Q G ++K+ +D S + +
Sbjct: 1419 LRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEE 1478
Query: 407 VLVRASLKKSTMGFGFTIIGGDR--PDEF----LQVKNVLKDGPAAQDGKIAPGDVIVDI 460
L K++ G GF+ D P++ ++VK + PAA+ GKI GDVI+ +
Sbjct: 1479 NTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKV 1538
Query: 461 NGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLT 520
NG + G + +V+ L V L LCR P P +D TP+ +
Sbjct: 1539 NGASLKGLSQQEVIS--ALRGTAPEVFLLLCR----PPPGVLPEIDTALLTPL-----QS 1587
Query: 521 KGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMA-SSGSSQPELVTI 579
+ N +EQ+ S D + +R S + SSGS + +LVT
Sbjct: 1588 PAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTA 1647
Query: 580 PLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVL 639
P I +S W L HQ + N+ + +
Sbjct: 1648 P---------------------ANISNSTWSSAL----------HQTLSNM--VSQAQSH 1674
Query: 640 KQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAIN-EPIPQPM----PFPPSI 694
+ P + + + P K N E N P+P M + P
Sbjct: 1675 HEAPKSQEDTICTMFYYP-----------QKIPNKPEFEDSNPSPLPPDMAPGQSYQPQS 1723
Query: 695 IRSGSPKLDPSEV-YLKSKTLYEDKPPNTKDLD--------------VFLRKQESGFGFR 739
+ S +D + ++ T E+ P DL+ ++ ++ GF
Sbjct: 1724 ESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFT 1783
Query: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARN 799
V G+ Y+ +I A+ DGRL+ D L+ ++ V +H ++L+ A++
Sbjct: 1784 VTKGN-QRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKT 1841
Query: 800 GHVLL 804
+++
Sbjct: 1842 VRLVI 1846
Score = 57.0 bits (136), Expect = 1e-07
Identities = 70/308 (22%), Positives = 130/308 (42%), Gaps = 51/308 (16%)
Query: 812 YGEKQPEDDSSQAFISTQNGSPRLN-RAEVPARPAPQEPYDVVLQRKENEGFGFVILTSK 870
Y Q Q S+ N S ++N + + P P + ++V L + +N G +
Sbjct: 1309 YSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNS-LGISVTGGV 1367
Query: 871 NKPPPGVIPHK---IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAG 927
N + H + VI A+ G++ GD + AVNG S+ +H V+ +++ G
Sbjct: 1368 NTS----VRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTG 1423
Query: 928 VTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTS 987
V L + E+ P S +H P+ D++A +G+ + V +
Sbjct: 1424 QVVHLLL---EKGQSPTSK----------EHVPVTPQCTL---SDQNA-QGQGPEKVKKT 1466
Query: 988 YRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGG-----KEYN 1042
+ D+ + + +T + V+L + G GFS ++ N
Sbjct: 1467 TQVK--DYSFVTEENT----------------FEVKLFKNSSGLGFSFSREDNLIPEQIN 1508
Query: 1043 MGLF-ILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL-R 1100
+ + +L PA + G+I VGD I+++NG +G++ I ++ +V LLL R
Sbjct: 1509 ASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1568
Query: 1101 PGTGLIPD 1108
P G++P+
Sbjct: 1569 PPPGVLPE 1576
Score = 44.7 bits (104), Expect = 5e-04
Identities = 70/288 (24%), Positives = 119/288 (41%), Gaps = 42/288 (14%)
Query: 221 KRTTSVSKMERMDSSLPEEEEDEDKEAINGSGNAENRERHSESS----DWMKTVPSY--N 274
K ++ S +E+ SS E D+ K+ + R+ +S+SS D + T P+ N
Sbjct: 1597 KDSSQPSCVEQSTSSDENEMSDKSKKQCK---SPSRRDSYSDSSGSGEDDLVTAPANISN 1653
Query: 275 QTNSS---MDFRNYMMRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAK 331
T SS N + + ++ PK+ E T M Y+ + D +
Sbjct: 1654 STWSSALHQTLSNMVSQAQSHHEAPKSQED--TICTMFYYPQKIPNKPEFEDSN---PSP 1708
Query: 332 APEDCEDGEL--PYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQVEIGSSK 389
P D G+ P E Y++ H+++ T+ EN K
Sbjct: 1709 LPPDMAPGQSYQPQS-ESASSSSMDKYHIHHISEPTRQENWTP---------------LK 1752
Query: 390 PDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDG 449
D+E +H + +L+ L+ +K GFT+ G++ V +V++D PA DG
Sbjct: 1753 NDLE-NHL--EDFELEVELLITLIKSEKGSLGFTVTKGNQRIG-CYVHDVIQD-PAKSDG 1807
Query: 450 KIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLP 497
++ PGD ++ +N V TH D V + L ++ V L + R LP
Sbjct: 1808 RLKPGDRLIKVNDTDVTNMTHTDAVNL--LRAASKTVRLVIGRVLELP 1853
Score = 44.3 bits (103), Expect = 7e-04
Identities = 23/78 (29%), Positives = 46/78 (58%), Gaps = 4/78 (5%)
Query: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
++ E+G GF++ G + +G ++ + +D PA DGR+ GD+++++N +TH
Sbjct: 1773 IKSEKG--SLGFTVTKGNQ-RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTH 1828
Query: 1082 TRAIELIQAGGNKVLLLL 1099
T A+ L++A V L++
Sbjct: 1829 TDAVNLLRAASKTVRLVI 1846
Score = 37.4 bits (85), Expect = 0.081
Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 6/83 (7%)
Query: 852 VVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSI 911
+ L + E GF + +K G H + + PA G+LK GD + VN +
Sbjct: 1770 ITLIKSEKGSLGFTV--TKGNQRIGCYVHDVIQ----DPAKSDGRLKPGDRLIKVNDTDV 1823
Query: 912 VELSHDNIVQLIKDAGVTVTLTV 934
++H + V L++ A TV L +
Sbjct: 1824 TNMTHTDAVNLLRAASKTVRLVI 1846
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 101 bits (252), Expect = 3e-21
Identities = 97/403 (24%), Positives = 161/403 (39%), Gaps = 62/403 (15%)
Query: 723 KDLDVFLRKQESGFGFRVLGGDGP------DQSIYIGAIIPLGAAEKDGRLRAADELMCI 776
++L + + +Q G G + GG G D+ I+I + G A + G +R D+L+ +
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 777 DGIPVKGKSHKQVLDLMTTAARNGHV------LLTVRRKIFYGEKQPEDDSSQAFISTQN 830
+G+ ++G H + ++ + A + ++ + +PEDD S +
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPR--ERRG 841
Query: 831 GSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPP--PGVIPHKIGRVIEG 888
G RL P P P V + G GF I K P G + R+ EG
Sbjct: 842 GGLRLPLLP-PESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
Query: 889 SPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTN 948
A R G L+VGD + ++NG + E HD+ V L+ A T+ L + E PPS
Sbjct: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP 960
Query: 949 SARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISV 1008
+ A + +PG S + +
Sbjct: 961 HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALE----------------------- 997
Query: 1009 VGSRHNQNLGCYPVELERGPRG---FGFSLRGGKEYNM--------GLFILRLAEDGPAI 1057
G YPVE R PR G S+ GG +++ G+FI ++ G A
Sbjct: 998 ---------GPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAA 1048
Query: 1058 KDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLR 1100
+ G + VGD+I+ +NG+ + TH A+ + ++ LL+R
Sbjct: 1049 RSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVR 1090
Score = 73.2 bits (178), Expect = 1e-12
Identities = 79/286 (27%), Positives = 114/286 (39%), Gaps = 54/286 (18%)
Query: 841 PARPAPQEPYDVVLQRKENEGFGFVILTSKNKPP-----PGVIPHKIGRVIEGSPADRCG 895
PAR +E +L ++ G G I K P G+ I RV E PA R G
Sbjct: 719 PARIEEEELTLTIL--RQTGGLGISIAGGKGSTPYKGDDEGIF---ISRVSEEGPAARAG 773
Query: 896 KLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPA 955
++VGD + VNG ++ H V+ ++ AG V + V E A
Sbjct: 774 -VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRER----------MVEPENA 822
Query: 956 LQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQ 1015
+ P+ P D D S R L P++ G +
Sbjct: 823 VTITPLR-------PED----------DYSPRERRGGGLRLPLLPPESP-----GPLRQR 860
Query: 1016 NLGCYPVELERGPRGFGFSLRGGKEY------NMGLFILRLAEDGPAIKDGRIHVGDQIV 1069
++ C L R RG GFS+ GGK + G+F+ R+AE G A + G + VGD+++
Sbjct: 861 HVAC----LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVL 916
Query: 1070 EINGEPTQGITHTRAIELIQAGGNKVLLLL-RPGTGLIPDHGLAPS 1114
ING H A+ L+ A + LLL R G +P L S
Sbjct: 917 SINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHS 962
Score = 67.8 bits (164), Expect = 6e-11
Identities = 136/609 (22%), Positives = 232/609 (38%), Gaps = 128/609 (21%)
Query: 539 EQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIA----D 594
E+ K G ++ + G S + + + + EL T+ +++ G G +IA
Sbjct: 690 EEEDKEGAVVSAPSVKGVSFDQANNLLIEPARIEEEEL-TLTILRQTGGLGISIAGGKGS 748
Query: 595 SPTGQKVKMILDSQWCQ-------GLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGAD 647
+P + I S+ + G++ GD + E+ +Q H + VE L+ G
Sbjct: 749 TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRG--AGTA 806
Query: 648 VPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEV 707
V + + R P ENA ++ P+ + P R G
Sbjct: 807 VQMRVWRERMVEP-----------ENAVTIT----PLRPEDDYSPRERRGGG-------- 843
Query: 708 YLKSKTLYEDKPPNTKDLDVF-LRKQESGFGFRVLGGDGP------DQSIYIGAIIPLGA 760
L+ L + P + V L + E G GF + GG G D I++ I GA
Sbjct: 844 -LRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGA 902
Query: 761 AEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDD 820
A + G L+ D ++ I+G+ V H + L+ TAA LL R
Sbjct: 903 AHRAGTLQVGDRVLSINGVDVTEARHDHAVSLL-TAASPTIALLLER------------- 948
Query: 821 SSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPH 880
+ G P +P P P V TS PGV
Sbjct: 949 --------EAGGP------LPPSPLPHSSPPTAA----------VATTSITTATPGV--- 981
Query: 881 KIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEH 940
G P+ L +A+ G VE + AG + L+++ +H
Sbjct: 982 ------PGLPSLAPSLLA-----AALEGPYPVEEIR------LPRAGGPLGLSIVGGSDH 1024
Query: 941 HGPPSGTNSARQSPAL---QHRPMGQSQANHIP-GDRS-ALEGEIGKDVSTSYRHSWSDH 995
P G Q P + + P G + + + GDR A+ G+ +D + S
Sbjct: 1025 SSHPFGV----QEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVS---- 1076
Query: 996 KHLAQPDTAVISVVGSRHNQNLGCYPVELERGP-RGFGFSLRGGKEYNMG---------L 1045
L +P +S++ R G + +++ P G S+RGG + G +
Sbjct: 1077 -ALLRP-CLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGI 1134
Query: 1046 FILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGL 1105
FI +++ G A +DGR+ VG +++E+N + G+TH A++L+++ G+ + +L+ G
Sbjct: 1135 FISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEA 1194
Query: 1106 IPDHGLAPS 1114
D L S
Sbjct: 1195 STDAALEVS 1203
Score = 42.7 bits (99), Expect = 0.002
Identities = 36/137 (26%), Positives = 57/137 (41%), Gaps = 11/137 (8%)
Query: 389 KPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGG---------DRPDEFLQVKNV 439
+P +E S R G+ K G +I GG D DE + + V
Sbjct: 1080 RPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKV 1139
Query: 440 LKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDD 499
G A +DG++ G ++++N +LG TH + VQ+ L V + + +C G+ D
Sbjct: 1140 SPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQL--LRSVGDTLTVLVCDGFEASTD 1197
Query: 500 SEDPVVDIVAATPVING 516
+ V V A P G
Sbjct: 1198 AALEVSPGVIANPFAAG 1214
Score = 42.0 bits (97), Expect = 0.003
Identities = 82/405 (20%), Positives = 133/405 (32%), Gaps = 90/405 (22%)
Query: 411 ASLKKSTMGFGFTIIGGD------RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNC 464
A L +S G GF+I GG D + V + + G A + G + GD ++ ING
Sbjct: 863 ACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVD 922
Query: 465 VLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDD---SEDPVVDIVAATPVINGQSLTK 521
V H V + + L G PLP P VA T +
Sbjct: 923 VTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVP 982
Query: 522 GETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPL 581
G + P +L L GP E R+ A + + +
Sbjct: 983 GLPSLAP------------------SLLAAALEGPYPVEEIRLPRAGGP------LGLSI 1018
Query: 582 IKGPKGFGFAIADSPTGQKVKMILDSQWC--QGLQKGDIIKEIYHQNVQNLTHLQVVEVL 639
+ G G + +L GL+ GD I + Q+V++ TH + V L
Sbjct: 1019 VGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSAL 1078
Query: 640 KQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGS 699
+ ++ LL+ R P + ++ E G IR G+
Sbjct: 1079 LR--PCLELSLLVRRDPAPPGLRELCIQKAPGERLG-----------------ISIRGGA 1119
Query: 700 PKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLG 759
+ P + D +F+ K + P G
Sbjct: 1120 RG-------------HAGNPRDPTDEGIFISK-----------------------VSPTG 1143
Query: 760 AAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLL 804
AA +DGRLR L+ ++ + G +H + + L+ + VL+
Sbjct: 1144 AAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 101 bits (252), Expect = 3e-21
Identities = 97/403 (24%), Positives = 161/403 (39%), Gaps = 62/403 (15%)
Query: 723 KDLDVFLRKQESGFGFRVLGGDGP------DQSIYIGAIIPLGAAEKDGRLRAADELMCI 776
++L + + +Q G G + GG G D+ I+I + G A + G +R D+L+ +
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 777 DGIPVKGKSHKQVLDLMTTAARNGHV------LLTVRRKIFYGEKQPEDDSSQAFISTQN 830
+G+ ++G H + ++ + A + ++ + +PEDD S +
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPR--ERRG 841
Query: 831 GSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPP--PGVIPHKIGRVIEG 888
G RL P P P V + G GF I K P G + R+ EG
Sbjct: 842 GGLRLPLLP-PESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
Query: 889 SPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTN 948
A R G L+VGD + ++NG + E HD+ V L+ A T+ L + E PPS
Sbjct: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP 960
Query: 949 SARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISV 1008
+ A + +PG S + +
Sbjct: 961 HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALE----------------------- 997
Query: 1009 VGSRHNQNLGCYPVELERGPRG---FGFSLRGGKEYNM--------GLFILRLAEDGPAI 1057
G YPVE R PR G S+ GG +++ G+FI ++ G A
Sbjct: 998 ---------GPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAA 1048
Query: 1058 KDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLR 1100
+ G + VGD+I+ +NG+ + TH A+ + ++ LL+R
Sbjct: 1049 RSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVR 1090
Score = 73.2 bits (178), Expect = 1e-12
Identities = 79/286 (27%), Positives = 114/286 (39%), Gaps = 54/286 (18%)
Query: 841 PARPAPQEPYDVVLQRKENEGFGFVILTSKNKPP-----PGVIPHKIGRVIEGSPADRCG 895
PAR +E +L ++ G G I K P G+ I RV E PA R G
Sbjct: 719 PARIEEEELTLTIL--RQTGGLGISIAGGKGSTPYKGDDEGIF---ISRVSEEGPAARAG 773
Query: 896 KLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPA 955
++VGD + VNG ++ H V+ ++ AG V + V E A
Sbjct: 774 -VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRER----------MVEPENA 822
Query: 956 LQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQ 1015
+ P+ P D D S R L P++ G +
Sbjct: 823 VTITPLR-------PED----------DYSPRERRGGGLRLPLLPPESP-----GPLRQR 860
Query: 1016 NLGCYPVELERGPRGFGFSLRGGKEY------NMGLFILRLAEDGPAIKDGRIHVGDQIV 1069
++ C L R RG GFS+ GGK + G+F+ R+AE G A + G + VGD+++
Sbjct: 861 HVAC----LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVL 916
Query: 1070 EINGEPTQGITHTRAIELIQAGGNKVLLLL-RPGTGLIPDHGLAPS 1114
ING H A+ L+ A + LLL R G +P L S
Sbjct: 917 SINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHS 962
Score = 67.8 bits (164), Expect = 6e-11
Identities = 136/609 (22%), Positives = 232/609 (38%), Gaps = 128/609 (21%)
Query: 539 EQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIA----D 594
E+ K G ++ + G S + + + + EL T+ +++ G G +IA
Sbjct: 690 EEEDKEGAVVSAPSVKGVSFDQANNLLIEPARIEEEEL-TLTILRQTGGLGISIAGGKGS 748
Query: 595 SPTGQKVKMILDSQWCQ-------GLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGAD 647
+P + I S+ + G++ GD + E+ +Q H + VE L+ G
Sbjct: 749 TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRG--AGTA 806
Query: 648 VPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEV 707
V + + R P ENA ++ P+ + P R G
Sbjct: 807 VQMRVWRERMVEP-----------ENAVTIT----PLRPEDDYSPRERRGGG-------- 843
Query: 708 YLKSKTLYEDKPPNTKDLDVF-LRKQESGFGFRVLGGDGP------DQSIYIGAIIPLGA 760
L+ L + P + V L + E G GF + GG G D I++ I GA
Sbjct: 844 -LRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGA 902
Query: 761 AEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDD 820
A + G L+ D ++ I+G+ V H + L+ TAA LL R
Sbjct: 903 AHRAGTLQVGDRVLSINGVDVTEARHDHAVSLL-TAASPTIALLLER------------- 948
Query: 821 SSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPH 880
+ G P +P P P V TS PGV
Sbjct: 949 --------EAGGP------LPPSPLPHSSPPTAA----------VATTSITTATPGV--- 981
Query: 881 KIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEH 940
G P+ L +A+ G VE + AG + L+++ +H
Sbjct: 982 ------PGLPSLAPSLLA-----AALEGPYPVEEIR------LPRAGGPLGLSIVGGSDH 1024
Query: 941 HGPPSGTNSARQSPAL---QHRPMGQSQANHIP-GDRS-ALEGEIGKDVSTSYRHSWSDH 995
P G Q P + + P G + + + GDR A+ G+ +D + S
Sbjct: 1025 SSHPFGV----QEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVS---- 1076
Query: 996 KHLAQPDTAVISVVGSRHNQNLGCYPVELERGP-RGFGFSLRGGKEYNMG---------L 1045
L +P +S++ R G + +++ P G S+RGG + G +
Sbjct: 1077 -ALLRP-CLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGI 1134
Query: 1046 FILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGL 1105
FI +++ G A +DGR+ VG +++E+N + G+TH A++L+++ G+ + +L+ G
Sbjct: 1135 FISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEA 1194
Query: 1106 IPDHGLAPS 1114
D L S
Sbjct: 1195 STDAALEVS 1203
Score = 42.7 bits (99), Expect = 0.002
Identities = 36/137 (26%), Positives = 57/137 (41%), Gaps = 11/137 (8%)
Query: 389 KPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGG---------DRPDEFLQVKNV 439
+P +E S R G+ K G +I GG D DE + + V
Sbjct: 1080 RPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKV 1139
Query: 440 LKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDD 499
G A +DG++ G ++++N +LG TH + VQ+ L V + + +C G+ D
Sbjct: 1140 SPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQL--LRSVGDTLTVLVCDGFEASTD 1197
Query: 500 SEDPVVDIVAATPVING 516
+ V V A P G
Sbjct: 1198 AALEVSPGVIANPFAAG 1214
Score = 42.0 bits (97), Expect = 0.003
Identities = 82/405 (20%), Positives = 133/405 (32%), Gaps = 90/405 (22%)
Query: 411 ASLKKSTMGFGFTIIGGD------RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNC 464
A L +S G GF+I GG D + V + + G A + G + GD ++ ING
Sbjct: 863 ACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVD 922
Query: 465 VLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDD---SEDPVVDIVAATPVINGQSLTK 521
V H V + + L G PLP P VA T +
Sbjct: 923 VTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVP 982
Query: 522 GETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPL 581
G + P +L L GP E R+ A + + +
Sbjct: 983 GLPSLAP------------------SLLAAALEGPYPVEEIRLPRAGGP------LGLSI 1018
Query: 582 IKGPKGFGFAIADSPTGQKVKMILDSQWC--QGLQKGDIIKEIYHQNVQNLTHLQVVEVL 639
+ G G + +L GL+ GD I + Q+V++ TH + V L
Sbjct: 1019 VGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSAL 1078
Query: 640 KQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGS 699
+ ++ LL+ R P + ++ E G IR G+
Sbjct: 1079 LR--PCLELSLLVRRDPAPPGLRELCIQKAPGERLG-----------------ISIRGGA 1119
Query: 700 PKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLG 759
+ P + D +F+ K + P G
Sbjct: 1120 RG-------------HAGNPRDPTDEGIFISK-----------------------VSPTG 1143
Query: 760 AAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLL 804
AA +DGRLR L+ ++ + G +H + + L+ + VL+
Sbjct: 1144 AAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 100 bits (248), Expect = 1e-20
Identities = 145/619 (23%), Positives = 239/619 (38%), Gaps = 79/619 (12%)
Query: 414 KKSTMGFGFTIIGGD---RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTH 470
K + G GF IIGG+ R D + + +V GPA DG + PGD ++ +N + G +H
Sbjct: 1098 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1157
Query: 471 ADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQD 530
+++ Q P + +TL P S+ P +TPV + + M
Sbjct: 1158 HAAIEILQNAPED----VTLVISQPKEKISKVP------STPV---HLTNEMKNYMKKSS 1204
Query: 531 FKPGAMVLEQNGKSGH----TLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPK 586
+ + + + + K H TL N + R SS S+ E ++ +
Sbjct: 1205 YMQDSAI-DSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNG 1263
Query: 587 GFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGA 646
F + D Q Q Q G + + + T + + P +
Sbjct: 1264 FFASHLGD-------------QTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGIS 1310
Query: 647 DVPLLILRGGPPSPTKTAKMKTD----KKENAGSLEAINEPIPQPMPFPPSIIRSGSPKL 702
DV RG T D K+E++ S+ N+ M F S PK
Sbjct: 1311 DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNK-----MNF--KTFSSSPPK- 1362
Query: 703 DPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAE 762
P +++ K N+ + V + + G V G IY+ A+IP GAAE
Sbjct: 1363 -PGDIFEVELA----KNDNSLGISVTVLFDKGGVNTSVRHG-----GIYVKAVIPQGAAE 1412
Query: 763 KDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSS 822
DGR+ D ++ ++G+ ++G +HKQ ++ + + H+LL + E P +
Sbjct: 1413 SDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPV--TP 1470
Query: 823 QAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQR--------KENEGFGFVILTSKNKPP 874
Q +S QN + E + + Y V + K + G GF N P
Sbjct: 1471 QCTLSDQNAQGQ--GPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIP 1528
Query: 875 PGVIPH--KIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTL 932
+ ++ ++ G PA GK+ VGD I VNG S+ LS ++ ++ V L
Sbjct: 1529 EQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFL 1588
Query: 933 TVIAEEEHHGPPSGTN--SARQSPA--LQHRPMGQSQANHIPGDRSALEGEIG-----KD 983
+ P T + QSPA L + SQ + + S+ E E+ +
Sbjct: 1589 LLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQC 1648
Query: 984 VSTSYRHSWSDHKHLAQPD 1002
S S R S+SD + D
Sbjct: 1649 KSPSRRDSYSDSSGSGEDD 1667
Score = 75.5 bits (184), Expect = 3e-13
Identities = 86/392 (21%), Positives = 156/392 (39%), Gaps = 61/392 (15%)
Query: 735 GFGFRVLGGDGP---DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD 791
G GF+++GG+ D I+I ++ P G A+ DG L+ D L+ ++ + ++G SH ++
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 792 LMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYD 851
++ A PED ++ P+ ++VP+ P +
Sbjct: 1163 ILQNA--------------------PED------VTLVISQPKEKISKVPSTPV-HLTNE 1195
Query: 852 VVLQRKENEGFGFVILTSKNKP---PPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNG 908
+ K++ + S +K G + H I + G L+ G S +
Sbjct: 1196 MKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRH-----ISENSFGPSGGLREGSLSSQDSR 1250
Query: 909 QSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANH 968
LS + T +E HG PS + ++ + QS+
Sbjct: 1251 TESASLSQSQVNGFFASHLGDQTW----QESQHGSPSPSVISKATEKETFTDSNQSKTKK 1306
Query: 969 IPG--DRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYP----- 1021
PG D + D+ + S DH+ Q ++ ++ + + P
Sbjct: 1307 -PGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGD 1365
Query: 1022 ---VELERGPRGFGFSL-----RGGKEYNM---GLFILRLAEDGPAIKDGRIHVGDQIVE 1070
VEL + G S+ +GG ++ G+++ + G A DGRIH GD+++
Sbjct: 1366 IFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLA 1425
Query: 1071 INGEPTQGITHTRAIELIQAGGNKVLLLLRPG 1102
+NG +G TH +A+E ++ G V LLL G
Sbjct: 1426 VNGVSLEGATHKQAVETLRNTGQVVHLLLEKG 1457
Score = 59.7 bits (143), Expect = 2e-08
Identities = 72/308 (23%), Positives = 130/308 (42%), Gaps = 46/308 (14%)
Query: 812 YGEKQPEDDSSQAFISTQNGSPRLN-RAEVPARPAPQEPYDVVLQRKENE-GFGFVILTS 869
Y Q Q S+ N S ++N + + P P + ++V L + +N G +L
Sbjct: 1328 YSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTVLFD 1387
Query: 870 KNKPPPGVIPHKI--GRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAG 927
K V I VI A+ G++ GD + AVNG S+ +H V+ +++ G
Sbjct: 1388 KGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTG 1447
Query: 928 VTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTS 987
V L + E+ P S +H P+ D++A +G+ + V +
Sbjct: 1448 QVVHLLL---EKGQSPTSK----------EHVPVTPQCTL---SDQNA-QGQGPEKVKKT 1490
Query: 988 YRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGG-----KEYN 1042
+ D+ + + +T + V+L + G GFS ++ N
Sbjct: 1491 TQVK--DYSFVTEENT----------------FEVKLFKNSSGLGFSFSREDNLIPEQIN 1532
Query: 1043 MGLF-ILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL-R 1100
+ + +L PA + G+I VGD I+++NG +G++ I ++ +V LLL R
Sbjct: 1533 ASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1592
Query: 1101 PGTGLIPD 1108
P G++P+
Sbjct: 1593 PPPGVLPE 1600
Score = 59.3 bits (142), Expect = 2e-08
Identities = 171/849 (20%), Positives = 304/849 (35%), Gaps = 157/849 (18%)
Query: 30 GAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLA 89
G +I GG + G LG G + G PGD L+ VN + G+++ +
Sbjct: 1105 GFQIIGGEKMGRLD-LGIFISSVAPGGPADLDG-CLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 90 VIRHFREPIRLKTVKPGKVINK----------DLRHYL--SLQFQKGSIDHKLQQVIRDN 137
++++ E + L +P + I+K ++++Y+ S Q +ID +
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSR 1222
Query: 138 LYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEES------GALLESGTYDGNFYGTP 191
LR I + P G G + S + +L +S + L T+ + +G+P
Sbjct: 1223 GTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSP 1282
Query: 192 KPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEEEDEDKEAINGS 251
P V + E +S + +T + D S + D D + S
Sbjct: 1283 SPS----------VISKATEKETFTDSNQSKTKKPGISDVTDYS---DRGDSDMDEATYS 1329
Query: 252 GNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNW---EMAYTDTGM 308
+ +++ ESS S T++ M+F+ + + P P + E+A D +
Sbjct: 1330 SSQDHQTPKQESS-------SSVNTSNKMNFKTF----SSSPPKPGDIFEVELAKNDNSL 1378
Query: 309 ----IYFIDHNTKTTTWLDPRLCKKAKAPEDC--EDGELPYG----------------WE 346
D T+ + KA P+ DG + G +
Sbjct: 1379 GISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQ 1438
Query: 347 KIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQL---GQVEIGSSKPDMEKSHFTRDPSQ 403
+E + V L +K Q E Q Q G ++K+ +D S
Sbjct: 1439 AVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSF 1498
Query: 404 L-KGVLVRASLKKSTMGFGFTIIGGDR--PDEF----LQVKNVLKDGPAAQDGKIAPGDV 456
+ + L K++ G GF+ D P++ ++VK + PAA+ GKI GDV
Sbjct: 1499 VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1558
Query: 457 IVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVING 516
I+ +NG + G + +V+ L V L LCR P P +D TP+
Sbjct: 1559 ILKVNGASLKGLSQQEVIS--ALRGTAPEVFLLLCR----PPPGVLPEIDTALLTPL--- 1609
Query: 517 QSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMA-SSGSSQPE 575
+ + N +EQ+ S D + +R S + SSGS + +
Sbjct: 1610 --QSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDD 1667
Query: 576 LVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQV 635
LVT P I +S W L HQ + N+ +
Sbjct: 1668 LVTAP---------------------ANISNSTWSSAL----------HQTLSNM--VSQ 1694
Query: 636 VEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAIN-EPIPQPM----PF 690
+ + P + + + P K N E N P+P M +
Sbjct: 1695 AQSHHEAPKSQEDTICTMFYYP-----------QKIPNKPEFEDSNPSPLPPDMAPGQSY 1743
Query: 691 PPSIIRSGSPKLDPSEV-YLKSKTLYEDKPPNTKDLD--------------VFLRKQESG 735
P + S +D + ++ T E+ P DL+ ++ ++
Sbjct: 1744 QPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGS 1803
Query: 736 FGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTT 795
GF V G+ Y+ +I A+ DGRL+ D L+ ++ V +H ++L+
Sbjct: 1804 LGFTVTKGN-QRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRA 1861
Query: 796 AARNGHVLL 804
A++ +++
Sbjct: 1862 ASKTVRLVI 1870
Score = 44.7 bits (104), Expect = 5e-04
Identities = 70/288 (24%), Positives = 119/288 (41%), Gaps = 42/288 (14%)
Query: 221 KRTTSVSKMERMDSSLPEEEEDEDKEAINGSGNAENRERHSESS----DWMKTVPSY--N 274
K ++ S +E+ SS E D+ K+ + R+ +S+SS D + T P+ N
Sbjct: 1621 KDSSQPSCVEQSTSSDENEMSDKSKKQCK---SPSRRDSYSDSSGSGEDDLVTAPANISN 1677
Query: 275 QTNSS---MDFRNYMMRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAK 331
T SS N + + ++ PK+ E T M Y+ + D +
Sbjct: 1678 STWSSALHQTLSNMVSQAQSHHEAPKSQED--TICTMFYYPQKIPNKPEFEDSN---PSP 1732
Query: 332 APEDCEDGEL--PYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQVEIGSSK 389
P D G+ P E Y++ H+++ T+ EN K
Sbjct: 1733 LPPDMAPGQSYQPQS-ESASSSSMDKYHIHHISEPTRQENWTP---------------LK 1776
Query: 390 PDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDG 449
D+E +H + +L+ L+ +K GFT+ G++ V +V++D PA DG
Sbjct: 1777 NDLE-NHL--EDFELEVELLITLIKSEKGSLGFTVTKGNQRIG-CYVHDVIQD-PAKSDG 1831
Query: 450 KIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLP 497
++ PGD ++ +N V TH D V + L ++ V L + R LP
Sbjct: 1832 RLKPGDRLIKVNDTDVTNMTHTDAVNL--LRAASKTVRLVIGRVLELP 1877
Score = 44.3 bits (103), Expect = 7e-04
Identities = 23/78 (29%), Positives = 46/78 (58%), Gaps = 4/78 (5%)
Query: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
++ E+G GF++ G + +G ++ + +D PA DGR+ GD+++++N +TH
Sbjct: 1797 IKSEKG--SLGFTVTKGNQ-RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTH 1852
Query: 1082 TRAIELIQAGGNKVLLLL 1099
T A+ L++A V L++
Sbjct: 1853 TDAVNLLRAASKTVRLVI 1870
Score = 41.2 bits (95), Expect = 0.006
Identities = 28/90 (31%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 852 VVLQRKENEGFGFVILTSKN--KPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQ 909
V L++ G GF I+ + + G+ I V G PAD G LK GD + +VN
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIF---ISSVAPGGPADLDGCLKPGDRLISVNSV 1150
Query: 910 SIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
S+ +SH ++++++A VTL + +E
Sbjct: 1151 SLEGVSHHAAIEILQNAPEDVTLVISQPKE 1180
Score = 37.4 bits (85), Expect = 0.081
Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 6/83 (7%)
Query: 852 VVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSI 911
+ L + E GF + +K G H + + PA G+LK GD + VN +
Sbjct: 1794 ITLIKSEKGSLGFTV--TKGNQRIGCYVHDVIQ----DPAKSDGRLKPGDRLIKVNDTDV 1847
Query: 912 VELSHDNIVQLIKDAGVTVTLTV 934
++H + V L++ A TV L +
Sbjct: 1848 TNMTHTDAVNLLRAASKTVRLVI 1870
>gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens]
Length = 817
Score = 96.3 bits (238), Expect = 1e-19
Identities = 118/469 (25%), Positives = 191/469 (40%), Gaps = 95/469 (20%)
Query: 655 GGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPS------EVY 708
G P+P AK+ ++ P+P P P P +PKL+ S E
Sbjct: 64 GATPTPRTKAKLIPTGRDVG--------PVP-PKPVPGK----STPKLNGSGPSWWPECT 110
Query: 709 LKSKTLYEDKPPNT---KDLDVFLRKQESGFGFRVLGG-DGP----DQSIYIGAIIPLGA 760
++ YE + K ++ L + SG GF + GG D P D I+I IIP GA
Sbjct: 111 CTNRDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGA 170
Query: 761 AEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDD 820
A DGRL D ++ ++ + V H + ++ + A V L VRR+
Sbjct: 171 AAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPV--VRLVVRRR----------- 217
Query: 821 SSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTS-KNKPPPGVIP 879
+P P+ +V L K +G GF I N+ PG
Sbjct: 218 ----------------------QPPPETIMEVNLL-KGPKGLGFSIAGGIGNQHIPGDNS 254
Query: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
I ++IEG A + G+L++GD + AVN ++ ++ H+ V +K+ V L V
Sbjct: 255 IYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGS 314
Query: 940 HH-----GPP--SGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSY---R 989
H PP + T +A + H N G A+E ++ R
Sbjct: 315 LHLNDMYAPPDYASTFTALADNHISH--------NSSLGYLGAVESKVSYPAPPQVPPTR 366
Query: 990 HSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILR 1049
+S LA+ D +R + + L +G G GF++ GG++ G+F+
Sbjct: 367 YSPIPRHMLAEEDF-------TREPRK-----IILHKGSTGLGFNIVGGED-GEGIFVSF 413
Query: 1050 LAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLL 1098
+ GPA G + GD+I+ +NG + TH +A ++ G V ++
Sbjct: 414 ILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
Score = 75.9 bits (185), Expect = 2e-13
Identities = 66/259 (25%), Positives = 112/259 (43%), Gaps = 41/259 (15%)
Query: 718 KPPNTKDLDVFLRKQESGFGFRVLGGDGP-----DQSIYIGAIIPLGAAEKDGRLRAADE 772
+PP ++V L K G GF + GG G D SIYI II GAA+KDGRL+ D
Sbjct: 218 QPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDR 277
Query: 773 LMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAF------- 825
L+ ++ ++ H++ + + + ++ + + + D + F
Sbjct: 278 LLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNH 337
Query: 826 ISTQNGSPRLNRAE-----------VPARPAP------------QEPYDVVLQRKENEGF 862
IS + L E P R +P +EP ++L K + G
Sbjct: 338 ISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIIL-HKGSTGL 396
Query: 863 GFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQL 922
GF I+ ++ G+ + ++ G PAD G+L+ GD I +VNG ++ +H+
Sbjct: 397 GFNIVGGED--GEGIF---VSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAA 451
Query: 923 IKDAGVTVTLTVIAEEEHH 941
+K AG +VT+ E +
Sbjct: 452 LKRAGQSVTIVAQYRPEEY 470
Score = 67.4 bits (163), Expect = 7e-11
Identities = 57/256 (22%), Positives = 110/256 (42%), Gaps = 37/256 (14%)
Query: 576 LVTIPLIKGPKGFGFAIADSPTGQKV---KMILDSQWCQG--------LQKGDIIKEIYH 624
++ + L+KGPKG GF+IA Q + I ++ +G LQ GD + + +
Sbjct: 224 IMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNN 283
Query: 625 QNVQNLTHLQVVEVLKQFPVGADVPLLILRGG---------PPSPTKTAKMKTDK----K 671
N+Q++ H + V LK V L + + G PP T D
Sbjct: 284 TNLQDVRHEEAVASLKN--TSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHN 341
Query: 672 ENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRK 731
+ G L A+ + P P P++ P+ + + ++ + + L K
Sbjct: 342 SSLGYLGAVESKVSYPAP----------PQVPPTRYSPIPRHMLAEEDFTREPRKIILHK 391
Query: 732 QESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD 791
+G GF ++GG+ + I++ I+ G A+ G LR D ++ ++G+ ++ +H+Q
Sbjct: 392 GSTGLGFNIVGGE-DGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAA 450
Query: 792 LMTTAARNGHVLLTVR 807
+ A ++ ++ R
Sbjct: 451 ALKRAGQSVTIVAQYR 466
Score = 57.8 bits (138), Expect = 6e-08
Identities = 42/149 (28%), Positives = 72/149 (48%), Gaps = 14/149 (9%)
Query: 969 IPGDRSALEGEIG--------KDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCY 1020
IPG +A++G +G +V S + L + V VV R
Sbjct: 166 IPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIM 225
Query: 1021 PVELERGPRGFGFSLRGG--KEYNMG---LFILRLAEDGPAIKDGRIHVGDQIVEINGEP 1075
V L +GP+G GFS+ GG ++ G ++I ++ E G A KDGR+ +GD+++ +N
Sbjct: 226 EVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTN 285
Query: 1076 TQGITHTRAIELIQAGGNKVLL-LLRPGT 1103
Q + H A+ ++ + V L + +PG+
Sbjct: 286 LQDVRHEEAVASLKNTSDMVYLKVAKPGS 314
Score = 55.8 bits (133), Expect = 2e-07
Identities = 29/84 (34%), Positives = 47/84 (55%), Gaps = 5/84 (5%)
Query: 1022 VELERGPRGFGFSLRGGKEY-----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
+ LERG G GFS+ GG + + G+FI ++ G A DGR+ V D ++ +N
Sbjct: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191
Query: 1077 QGITHTRAIELIQAGGNKVLLLLR 1100
+ H+RA+E ++ G V L++R
Sbjct: 192 SEVVHSRAVEALKEAGPVVRLVVR 215
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/79 (32%), Positives = 41/79 (51%), Gaps = 8/79 (10%)
Query: 392 MEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKI 451
+ + FTR+P ++ L K + G GF I+GG+ E + V +L GPA G++
Sbjct: 375 LAEEDFTREPRKI-------ILHKGSTGLGFNIVGGE-DGEGIFVSFILAGGPADLSGEL 426
Query: 452 APGDVIVDINGNCVLGHTH 470
GD I+ +NG + TH
Sbjct: 427 RRGDRILSVNGVNLRNATH 445
Score = 42.4 bits (98), Expect = 0.003
Identities = 21/49 (42%), Positives = 30/49 (61%), Gaps = 1/49 (2%)
Query: 143 IPCTTRAPRDGEVPGVDYNF-ISVEQFKALEESGALLESGTYDGNFYGT 190
+P TTR RD EV G DY+F +S EQ + + +E+G ++ N YGT
Sbjct: 656 VPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGT 704
Score = 37.4 bits (85), Expect = 0.081
Identities = 53/249 (21%), Positives = 88/249 (35%), Gaps = 33/249 (13%)
Query: 408 LVRASLKKSTMGFGFTIIGG-----DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDING 462
++ +L K G GF+I GG D + + +++ G A +DG++ GD ++ +N
Sbjct: 224 IMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNN 283
Query: 463 NCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKG 522
+ H + V + Y+ + L D P D + + ++
Sbjct: 284 TNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPP--DYASTFTALADNHISHN 341
Query: 523 ETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVS-----MASSGSSQPELV 577
+ G G + P R S M + E
Sbjct: 342 SSL----------------GYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPR 385
Query: 578 TIPLIKGPKGFGFAIADSPTGQK--VKMIL---DSQWCQGLQKGDIIKEIYHQNVQNLTH 632
I L KG G GF I G+ V IL + L++GD I + N++N TH
Sbjct: 386 KIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATH 445
Query: 633 LQVVEVLKQ 641
Q LK+
Sbjct: 446 EQAAAALKR 454
Score = 31.2 bits (69), Expect = 5.8
Identities = 26/95 (27%), Positives = 42/95 (44%), Gaps = 11/95 (11%)
Query: 24 GPPGDFGAEIRGGAERGEFP-----YLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTP 78
GP G G I GG P Y+ ++ E G G+ GD LL VN T
Sbjct: 232 GPKG-LGFSIAGGIGNQHIPGDNSIYITKIIE----GGAAQKDGRLQI-GDRLLAVNNTN 285
Query: 79 VSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDL 113
+ + + + +A +++ + + LK KPG + D+
Sbjct: 286 LQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDM 320
>gi|156546890 WW and C2 domain containing 2 [Homo sapiens]
Length = 1192
Score = 90.9 bits (224), Expect = 6e-18
Identities = 43/92 (46%), Positives = 58/92 (63%), Gaps = 6/92 (6%)
Query: 294 PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPR-LCKKAKAPEDCEDGELPYGWEKIEDPQ 352
PLP+ WE A G +++IDHNT+ T+W+DPR K + DC ELP+GWE DPQ
Sbjct: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQ 70
Query: 353 YGTYYVDHLNQKTQFENPVEEAKRKKQLGQVE 384
G YY+DH+N+ TQ E+P RK+ G+ E
Sbjct: 71 IGVYYIDHINKTTQIEDP-----RKQWRGEQE 97
Score = 32.0 bits (71), Expect = 3.4
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 293 EPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPR 325
+ LP WE + +Y+IDH KTT DPR
Sbjct: 57 DELPWGWEAGFDPQIGVYYIDHINKTTQIEDPR 89
>gi|21361142 PDZ domain containing 1 [Homo sapiens]
Length = 519
Score = 87.0 bits (214), Expect = 9e-17
Identities = 129/517 (24%), Positives = 214/517 (41%), Gaps = 87/517 (16%)
Query: 587 GFGFAIADSPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPV 644
GF I G V+++ + GLQ GD + I V H+QVV+++++
Sbjct: 21 GFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKS-- 78
Query: 645 GADVPLLILRGGPPSPTKTAKMKTDKKENAGSL--EAINEPIPQPMPFPPSIIRSGSPKL 702
G V LL+L G S K K + D KE S + +++ I P ++ G
Sbjct: 79 GNSVTLLVLDGD--SYEKAVKTRVDLKELGQSQKEQGLSDNILSP------VMNGGV--- 127
Query: 703 DPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAE 762
+ + + + Y L K+ +GF + G + +Y+ I P G A
Sbjct: 128 ---QTWTQPRLCY-------------LVKEGGSYGFSLKTVQGK-KGVYMTDITPQGVAM 170
Query: 763 KDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSS 822
+ G L A D L+ ++G V+ SH++V++ + + LL + +K+ +
Sbjct: 171 RAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKET----DKRHVEQKI 225
Query: 823 QAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKI 882
Q R + P +P +V +K + G+GF + + G I I
Sbjct: 226 Q-----------FKRETASLKLLPHQPR-IVEMKKGSNGYGFYLRAGSEQK--GQI---I 268
Query: 883 GRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHG 942
+ GSPA+ G LK D + AVNG+S+ L HD++V++I+ G +L V+ +E
Sbjct: 269 KDIDSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKE---- 323
Query: 943 PPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPD 1002
+ A SP L + Q+ +P + E TS S + PD
Sbjct: 324 TDNMYRLAHFSPFLYY------QSQELP---NGSVKEAPAPTPTSLEVS-------SPPD 367
Query: 1003 TAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRI 1062
T H L L +G G+GF L + G FI + + GPA G +
Sbjct: 368 T----TEEVDHKPKL----CRLAKGENGYGFHLNAIRGL-PGSFIKEVQKGGPADLAG-L 417
Query: 1063 HVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
D I+E+NG + + ++ IQ+ G V LL+
Sbjct: 418 EDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLV 454
Score = 64.7 bits (156), Expect = 5e-10
Identities = 59/251 (23%), Positives = 108/251 (43%), Gaps = 46/251 (18%)
Query: 849 PYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNG 908
P + L ++E + +GF + K+ H + V + SPA++ G L+ GD + +NG
Sbjct: 7 PRECKLSKQEGQNYGFFLRIEKDTEG-----HLVRVVEKCSPAEKAG-LQDGDRVLRING 60
Query: 909 QSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANH 968
+ + H +V L++ +G +VTL V+ + + + + +GQSQ
Sbjct: 61 VFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSY--------EKAVKTRVDLKELGQSQ--- 109
Query: 969 IPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGP 1028
L I V +W+ QP CY V+ E G
Sbjct: 110 ---KEQGLSDNILSPVMNGGVQTWT------QPRL---------------CYLVK-EGGS 144
Query: 1029 RGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELI 1088
GF GK+ G+++ + G A++ G + D ++E+NGE + +H +E +
Sbjct: 145 YGFSLKTVQGKK---GVYMTDITPQGVAMRAG-VLADDHLIEVNGENVEDASHEEVVEKV 200
Query: 1089 QAGGNKVLLLL 1099
+ G++V+ LL
Sbjct: 201 KKSGSRVMFLL 211
Score = 46.6 bits (109), Expect = 1e-04
Identities = 77/387 (19%), Positives = 148/387 (38%), Gaps = 75/387 (19%)
Query: 572 SQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQN 629
+QP L + G GF G + I G+ D + E+ +NV++
Sbjct: 131 TQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVED 190
Query: 630 LTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMP 689
+H +VVE +K+ G+ V L++ + + + K K SL+ + P
Sbjct: 191 ASHEEVVEKVKKS--GSRVMFLLV--DKETDKRHVEQKIQFKRETASLKLL--------P 238
Query: 690 FPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQS 749
P I+ ++K +G+GF + G +Q
Sbjct: 239 HQPRIVE--------------------------------MKKGSNGYGFYLRAGS--EQK 264
Query: 750 IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRK 809
I I G+ ++ L+ D ++ ++G V+ H V++++ +L+ +
Sbjct: 265 GQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKET 324
Query: 810 ------------IFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYD----VV 853
++Y ++ + S + + +P EV + P E D +
Sbjct: 325 DNMYRLAHFSPFLYYQSQELPNGSVK-----EAPAPTPTSLEVSSPPDTTEEVDHKPKLC 379
Query: 854 LQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVE 913
K G+GF + + P I V +G PAD G L+ D I VNG ++++
Sbjct: 380 RLAKGENGYGFHLNAIRGLPGSF-----IKEVQKGGPADLAG-LEDEDVIIEVNGVNVLD 433
Query: 914 LSHDNIVQLIKDAGVTVTLTVIAEEEH 940
++ +V I+ +G VTL V ++ +
Sbjct: 434 EPYEKVVDRIQSSGKNVTLLVCGKKAY 460
Score = 46.2 bits (108), Expect = 2e-04
Identities = 58/224 (25%), Positives = 100/224 (44%), Gaps = 34/224 (15%)
Query: 729 LRKQES---GFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKS 785
L KQE GF R+ + + + + AEK G L+ D ++ I+G+ V +
Sbjct: 12 LSKQEGQNYGFFLRI---EKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEE 67
Query: 786 HKQVLDLMTTAARNGHVLL--------TVRRKI---FYGEKQPEDDSSQAFISTQNGSPR 834
H QV+DL+ + + +L+ V+ ++ G+ Q E S + SP
Sbjct: 68 HMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNIL-----SPV 122
Query: 835 LNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRC 894
+N V P+ Y V KE +GF + T + K GV + + A R
Sbjct: 123 MN-GGVQTWTQPRLCYLV----KEGGSYGFSLKTVQGK--KGVY---MTDITPQGVAMRA 172
Query: 895 GKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEE 938
G L DH+ VNG+++ + SH+ +V+ +K +G V ++ +E
Sbjct: 173 GVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKE 215
Score = 43.1 bits (100), Expect = 0.001
Identities = 57/250 (22%), Positives = 108/250 (43%), Gaps = 37/250 (14%)
Query: 573 QPELVTIPLIKGPKGFGFAI--ADSPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQ 628
QP +V + KG G+GF + GQ +K I + GL+ D++ + ++V+
Sbjct: 240 QPRIVEMK--KGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVE 297
Query: 629 NLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPM 688
L H VVE+++ +GG + +TD Q +
Sbjct: 298 TLDHDSVVEMIR-------------KGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQEL 344
Query: 689 PFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPN-TKDLD-----VFLRKQESGFGFRVLG 742
P +GS K P+ +L PP+ T+++D L K E+G+GF +
Sbjct: 345 P-------NGSVKEAPAPT---PTSLEVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNA 394
Query: 743 GDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHV 802
G S +I + G A+ G L D ++ ++G+ V + +++V+D + ++ +N +
Sbjct: 395 IRGLPGS-FIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTL 452
Query: 803 LLTVRRKIFY 812
L+ ++ Y
Sbjct: 453 LVCGKKAYDY 462
Score = 40.8 bits (94), Expect = 0.007
Identities = 86/377 (22%), Positives = 148/377 (39%), Gaps = 85/377 (22%)
Query: 315 NTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQ----------- 363
N TW PRLC K E G + + ++ + G Y D Q
Sbjct: 124 NGGVQTWTQPRLCYLVK-----EGGSYGFSLKTVQGKK-GVYMTDITPQGVAMRAGVLAD 177
Query: 364 ----KTQFENPVEEAKRKKQLGQVEIGSSK-------PDMEKSH------FTRDPSQLKG 406
+ EN VE+A ++ + +V+ S+ + +K H F R+ + LK
Sbjct: 178 DHLIEVNGEN-VEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKL 236
Query: 407 VLVR---ASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKD---GPAAQDGKIAPGDVIVDI 460
+ + +KK + G+GF + G Q ++KD G A++ + D++V +
Sbjct: 237 LPHQPRIVEMKKGSNGYGFYLRAGSE-----QKGQIIKDIDSGSPAEEAGLKNNDLVVAV 291
Query: 461 NGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLT 520
NG V H VV+M + +L + D D + + +P + QS
Sbjct: 292 NGESVETLDHDSVVEMIR--KGGDQTSLLVV------DKETDNMYRLAHFSPFLYYQS-- 341
Query: 521 KGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIP 580
Q+ G++ T T ++ P D +E+ +P+L
Sbjct: 342 --------QELPNGSV----KEAPAPTPTSLEVSSPPDTTEE-------VDHKPKLCR-- 380
Query: 581 LIKGPKGFGF---AIADSPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQNLTHLQV 635
L KG G+GF AI P G +K + GL+ D+I E+ NV + + +V
Sbjct: 381 LAKGENGYGFHLNAIRGLP-GSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKV 439
Query: 636 VEVLKQFPVGADVPLLI 652
V+ ++ G +V LL+
Sbjct: 440 VDRIQS--SGKNVTLLV 454
Score = 35.8 bits (81), Expect = 0.23
Identities = 23/74 (31%), Positives = 39/74 (52%), Gaps = 2/74 (2%)
Query: 1029 RGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELI 1088
+ +GF LR K+ G + + + PA K G + GD+++ ING H + ++L+
Sbjct: 18 QNYGFFLRIEKDTE-GHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDLV 75
Query: 1089 QAGGNKVLLLLRPG 1102
+ GN V LL+ G
Sbjct: 76 RKSGNSVTLLVLDG 89
Score = 34.3 bits (77), Expect = 0.68
Identities = 39/125 (31%), Positives = 54/125 (43%), Gaps = 14/125 (11%)
Query: 387 SSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAA 446
SS PD T + K L R + ++ GF I G P F +K V K GPA
Sbjct: 363 SSPPD------TTEEVDHKPKLCRLAKGENGYGFHLNAIRG-LPGSF--IKEVQKGGPAD 413
Query: 447 QDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLC--RGYPLPDDSEDPV 504
G + DVI+++NG VL + VV Q N V L +C + Y + P+
Sbjct: 414 LAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKN--VTLLVCGKKAYDYFQAKKIPI 470
Query: 505 VDIVA 509
V +A
Sbjct: 471 VSSLA 475
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 86.3 bits (212), Expect = 2e-16
Identities = 62/242 (25%), Positives = 118/242 (48%), Gaps = 9/242 (3%)
Query: 687 PMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGD-- 744
P PPS +P P V+ + + + K L++ L+K G GF + D
Sbjct: 427 PSGKPPS-----APASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVT 481
Query: 745 -GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHV- 802
G IY+ I+P GAA +DGRL+A D L+ ++G+ + GKS ++V+ L+ + G V
Sbjct: 482 IGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVS 541
Query: 803 LLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGF 862
LL R++ + ++ + SQ I + + + P ++V L + G
Sbjct: 542 LLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGL 601
Query: 863 GFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQL 922
G + +++K + + +I G A + G+L+V D + AVNG+S++ ++ + ++
Sbjct: 602 GVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMET 661
Query: 923 IK 924
++
Sbjct: 662 LR 663
Score = 68.6 bits (166), Expect = 3e-11
Identities = 63/249 (25%), Positives = 108/249 (43%), Gaps = 51/249 (20%)
Query: 856 RKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELS 915
+K EG GF I TS++ G P + ++ A + G+LK GD + VNG +V S
Sbjct: 465 KKGTEGLGFSI-TSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKS 523
Query: 916 HDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQAN-HIPGDRS 974
+ +V L++ + T++++ RQ A R + + IP +
Sbjct: 524 QEEVVSLLRSTKMEGTVSLLV-------------FRQEDAFHPRELNAEPSQMQIPKETK 570
Query: 975 ALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL-ERGPRGFGF 1033
A + +I V++ G+R + V L + G G G
Sbjct: 571 AEDEDI------------------------VLTPDGTREFLT---FEVPLNDSGSAGLGV 603
Query: 1034 SLRGGKEY----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
S++G + ++G+F+ + G A KDGR+ V DQ++ +NGE G T+ A+E ++
Sbjct: 604 SVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663
Query: 1090 AG----GNK 1094
GNK
Sbjct: 664 RSMSTEGNK 672
Score = 55.1 bits (131), Expect = 4e-07
Identities = 32/93 (34%), Positives = 51/93 (54%), Gaps = 9/93 (9%)
Query: 406 GVLVRASLKKSTMGFGFTI------IGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVD 459
G + LKK T G GF+I IGG P + VKN+L G A QDG++ GD +++
Sbjct: 457 GKRLNIQLKKGTEGLGFSITSRDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIE 513
Query: 460 INGNCVLGHTHADVVQMFQLVPVNQYVNLTLCR 492
+NG ++G + +VV + + + V+L + R
Sbjct: 514 VNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 52.8 bits (125), Expect = 2e-06
Identities = 64/284 (22%), Positives = 116/284 (40%), Gaps = 63/284 (22%)
Query: 554 NGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIA--DSPTGQKVKMILDSQWCQ 611
+ P + VS + + + I L KG +G GF+I D G + + + +
Sbjct: 437 SAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR 496
Query: 612 G-------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTA 664
G L+ GD + E+ ++ + +VV +L+ + V LL+ R
Sbjct: 497 GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFR---------- 546
Query: 665 KMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDK-----P 719
+E+A +N +PS++ + +T ED+ P
Sbjct: 547 ------QEDAFHPRELN--------------------AEPSQMQIPKETKAEDEDIVLTP 580
Query: 720 PNTKDLDVF----LRKQESGFGFRVLGG----DGPDQSIYIGAIIPLGAAEKDGRLRAAD 771
T++ F +G G V G + D I++ +II GAA KDGRLR D
Sbjct: 581 DGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVND 640
Query: 772 ELMCIDGIPVKGKSHKQVLD-----LMTTAARNGHVLLTVRRKI 810
+L+ ++G + GK+++ ++ + T + G + L V R+I
Sbjct: 641 QLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRI 684
Score = 45.1 bits (105), Expect = 4e-04
Identities = 20/73 (27%), Positives = 43/73 (58%), Gaps = 5/73 (6%)
Query: 1022 VELERGPRGFGFSLRGGKEYNMG----LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQ 1077
++L++G G GFS+ ++ +G +++ + G AI+DGR+ GD+++E+NG
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 1078 GITHTRAIELIQA 1090
G + + L+++
Sbjct: 521 GKSQEEVVSLLRS 533
Score = 37.4 bits (85), Expect = 0.081
Identities = 17/61 (27%), Positives = 35/61 (57%), Gaps = 4/61 (6%)
Query: 419 GFGFTIIGG----DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVV 474
G G ++ G + D + VK+++ G A++DG++ D ++ +NG +LG T+ D +
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 475 Q 475
+
Sbjct: 660 E 660
>gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens]
Length = 1113
Score = 85.5 bits (210), Expect = 3e-16
Identities = 38/87 (43%), Positives = 54/87 (62%), Gaps = 1/87 (1%)
Query: 294 PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPR-LCKKAKAPEDCEDGELPYGWEKIEDPQ 352
PLP+ WE A G +Y+IDH +TT+W+DPR K DC ELP GWE+ DPQ
Sbjct: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQ 66
Query: 353 YGTYYVDHLNQKTQFENPVEEAKRKKQ 379
G Y++DH + TQ E+P + +R+++
Sbjct: 67 VGDYFIDHNTKTTQIEDPRVQWRREQE 93
Score = 42.0 bits (97), Expect = 0.003
Identities = 25/58 (43%), Positives = 31/58 (53%), Gaps = 5/58 (8%)
Query: 274 NQTNSSMDFRNYMMRDETL-----EPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRL 326
N+T S +D R+ + T + LP WE AY YFIDHNTKTT DPR+
Sbjct: 29 NRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRV 86
>gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens]
Length = 1118
Score = 85.5 bits (210), Expect = 3e-16
Identities = 38/87 (43%), Positives = 54/87 (62%), Gaps = 1/87 (1%)
Query: 294 PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPR-LCKKAKAPEDCEDGELPYGWEKIEDPQ 352
PLP+ WE A G +Y+IDH +TT+W+DPR K DC ELP GWE+ DPQ
Sbjct: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQ 66
Query: 353 YGTYYVDHLNQKTQFENPVEEAKRKKQ 379
G Y++DH + TQ E+P + +R+++
Sbjct: 67 VGDYFIDHNTKTTQIEDPRVQWRREQE 93
Score = 42.0 bits (97), Expect = 0.003
Identities = 25/58 (43%), Positives = 31/58 (53%), Gaps = 5/58 (8%)
Query: 274 NQTNSSMDFRNYMMRDETL-----EPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRL 326
N+T S +D R+ + T + LP WE AY YFIDHNTKTT DPR+
Sbjct: 29 NRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRV 86
>gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens]
Length = 1119
Score = 85.5 bits (210), Expect = 3e-16
Identities = 38/87 (43%), Positives = 54/87 (62%), Gaps = 1/87 (1%)
Query: 294 PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPR-LCKKAKAPEDCEDGELPYGWEKIEDPQ 352
PLP+ WE A G +Y+IDH +TT+W+DPR K DC ELP GWE+ DPQ
Sbjct: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQ 66
Query: 353 YGTYYVDHLNQKTQFENPVEEAKRKKQ 379
G Y++DH + TQ E+P + +R+++
Sbjct: 67 VGDYFIDHNTKTTQIEDPRVQWRREQE 93
Score = 42.0 bits (97), Expect = 0.003
Identities = 25/58 (43%), Positives = 31/58 (53%), Gaps = 5/58 (8%)
Query: 274 NQTNSSMDFRNYMMRDETL-----EPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRL 326
N+T S +D R+ + T + LP WE AY YFIDHNTKTT DPR+
Sbjct: 29 NRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRV 86
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 81.6 bits (200), Expect = 4e-15
Identities = 103/432 (23%), Positives = 183/432 (42%), Gaps = 57/432 (13%)
Query: 548 LTGDGLNGPSDASEQRVSMASSGSS---QP--ELVTIPLIKGP-KGFGFAIADSP-TGQK 600
+T D L+GP S S + S +P E+V + L + P +GFGF I + +GQ
Sbjct: 718 MTWDSLSGPPVQSMHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQA 777
Query: 601 VKMILDSQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLI 652
I S G ++ G I + H +++ T V +++ P ++ +
Sbjct: 778 DPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQ 837
Query: 653 LRG-GPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSI----------------- 694
+G G +P D+++N+ + ++ + S+
Sbjct: 838 SKGVGGNNP--------DEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMA 889
Query: 695 -IRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLD------VFLRKQESGFGFRVLGGDG-- 745
++S P+L +L K PP+ ++ V L K++ GF V GG
Sbjct: 890 GVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTS 949
Query: 746 -PDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLL 804
P IY+ +I+P G A K+G++ D L+ +DG+ + G +HKQ + +T + ++L
Sbjct: 950 VPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVL 1009
Query: 805 TVRRKIFYGEKQPEDDS---SQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENE- 860
R + +DS + +S P + V P+ ++V L++ N
Sbjct: 1010 ERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPK--FEVKLKKNANGL 1067
Query: 861 GFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIV 920
GF FV + ++ +I R+ G PA+ G + GD I AVNG+S L ++
Sbjct: 1068 GFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVL 1127
Query: 921 QLIKDAGVTVTL 932
L++ A VTL
Sbjct: 1128 HLLRGAPQEVTL 1139
Score = 69.7 bits (169), Expect = 1e-11
Identities = 75/288 (26%), Positives = 127/288 (44%), Gaps = 23/288 (7%)
Query: 827 STQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSK--NKPPPGVIPHKIGR 884
S GS R A P +E V L+R + GFGFVI + + PG+ I
Sbjct: 730 SMHAGSKNNRRKSFIAEPG-REIVRVTLKRDPHRGFGFVINEGEYSGQADPGIF---ISS 785
Query: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHG-- 942
+I G PA++ +K G I A+N S+ + + V++I+++ + L + + G
Sbjct: 786 IIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNN 845
Query: 943 PPSGTNSARQSPA-----LQHRPMGQSQANHIPGDRSALEGEIG--KDVSTSYRHSWSDH 995
P NS S L G ++ DR+ E ++ + + RH S
Sbjct: 846 PDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLS-- 903
Query: 996 KHLAQPDTAVISVVGSRHNQNLG-CYPVELERGPRGFGFSLRGGKEYNM---GLFILRLA 1051
A S S + G Y VEL + GFS+ GG ++ G+++ +
Sbjct: 904 --FLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIV 961
Query: 1052 EDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
GPA K+G+I GD++++++G G+TH +A++ + G L+L
Sbjct: 962 PGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVL 1009
Score = 65.1 bits (157), Expect = 4e-10
Identities = 90/438 (20%), Positives = 166/438 (37%), Gaps = 103/438 (23%)
Query: 730 RKQESGFGFRVLGGD---GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
R GFGF + G+ D I+I +IIP G AEK ++ +++ ++ I ++G +
Sbjct: 758 RDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTF 817
Query: 787 KQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFIS------------------- 827
+ ++ + N ++++ + + G P+++ + S
Sbjct: 818 NMAVRMIQNSPDNIELIISQSKGV--GGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSH 875
Query: 828 ---------------TQNGSPRLNR--AEVPARPA----PQEPYDV-------VLQRKEN 859
Q+ PRL + +P + A P P ++ V KE+
Sbjct: 876 TQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKED 935
Query: 860 EGFGFVILTSKNKPPP--GVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHD 917
GF + N P G+ + ++ G PA + G++ GD + V+G + L+H
Sbjct: 936 GTLGFSVTGGINTSVPYGGIY---VKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHK 992
Query: 918 NIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALE 977
VQ + G L + E P S + ++ S +PG
Sbjct: 993 QAVQCLTGPGQVARLVL----ERRVPRSTQQCPSANDSMGDERTAVSLVTALPG------ 1042
Query: 978 GEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRG 1037
+P + V G + + V+L++ G GFS
Sbjct: 1043 ----------------------RPSSCVSVTDGPK-------FEVKLKKNANGLGFSFVQ 1073
Query: 1038 GKEYNMG------LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAG 1091
++ + + I RL PA ++G I GD I+ +NG T+G+ + L++
Sbjct: 1074 MEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGA 1133
Query: 1092 GNKV-LLLLRPGTGLIPD 1108
+V LLL RP G +P+
Sbjct: 1134 PQEVTLLLCRPPPGALPE 1151
Score = 52.4 bits (124), Expect = 2e-06
Identities = 102/446 (22%), Positives = 180/446 (40%), Gaps = 68/446 (15%)
Query: 388 SKPDMEKSHFTRDPSQLKGVLVRASLKKST-MGFGFTIIGGD---RPDEFLQVKNVLKDG 443
SK + KS F +P + +VR +LK+ GFGF I G+ + D + + +++ G
Sbjct: 735 SKNNRRKS-FIAEPGR---EIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGG 790
Query: 444 PAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGY--PLPDDSE 501
PA + I PG I+ +N + G T V+M Q P N + ++ +G PD+ +
Sbjct: 791 PAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEK 850
Query: 502 DPVVDI-VAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNG------KSGHTLTGDGLN 554
+ + V++T +++ +G + QD L+ G + H L+ L
Sbjct: 851 NSTANSGVSSTDILSFG--YQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLK 908
Query: 555 GPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPT------GQKVKMILD-- 606
G + S+G E+ + L+K GF++ G VK I+
Sbjct: 909 GAGSSCPPSPPEISAG----EIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGG 964
Query: 607 --SQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTA 664
++ Q LQ GD + ++ + LTH Q V+ L V L+L P T+
Sbjct: 965 PAAKEGQILQ-GDRLLQVDGVILCGLTHKQAVQCLTG---PGQVARLVLERRVPRSTQQC 1020
Query: 665 KMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKD 724
D + + ++ +P G P S D P
Sbjct: 1021 PSANDSMGDERTAVSLVTALP------------GRP---------SSCVSVTDGP----K 1055
Query: 725 LDVFLRKQESGFGFRVLGGDGPDQS------IYIGAIIPLGAAEKDGRLRAADELMCIDG 778
+V L+K +G GF + + S + I + P AE++G + A D ++ ++G
Sbjct: 1056 FEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 1115
Query: 779 IPVKGKSHKQVLDLMTTAARNGHVLL 804
+G ++VL L+ A + +LL
Sbjct: 1116 RSTEGLIFQEVLHLLRGAPQEVTLLL 1141
Score = 49.7 bits (117), Expect = 2e-05
Identities = 43/179 (24%), Positives = 81/179 (45%), Gaps = 23/179 (12%)
Query: 406 GVLVRASLKKSTMGFGFTIIGGDRPD------EFLQVKNVLKDGPAAQDGKIAPGDVIVD 459
G LKK+ G GF+ + ++ + +++K + PA ++G IA GD+I+
Sbjct: 1053 GPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILA 1112
Query: 460 INGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYP--LPDDSEDPVVDIVAATPVINGQ 517
+NG G +V+ + + P Q V L LCR P LP+ ++ ++A
Sbjct: 1113 VNGRSTEGLIFQEVLHLLRGAP--QEVTLLLCRPPPGALPELEQEWQTPELSADKEFTRA 1170
Query: 518 SLTKGETCMNPQDFKPGAMVLEQNGK---SGHTLTGDGLNGPSDASEQRVSMASSGSSQ 573
+ T ++C +P +L+Q S G+GL ++S++ + A G ++
Sbjct: 1171 TCT--DSCTSP--------ILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNR 1219
Score = 46.2 bits (108), Expect = 2e-04
Identities = 29/88 (32%), Positives = 46/88 (52%), Gaps = 4/88 (4%)
Query: 1022 VELERGP-RGFGFSLRGGK---EYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQ 1077
V L+R P RGFGF + G+ + + G+FI + GPA K I G QI+ +N +
Sbjct: 754 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 813
Query: 1078 GITHTRAIELIQAGGNKVLLLLRPGTGL 1105
G T A+ +IQ + + L++ G+
Sbjct: 814 GFTFNMAVRMIQNSPDNIELIISQSKGV 841
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 81.6 bits (200), Expect = 4e-15
Identities = 103/432 (23%), Positives = 183/432 (42%), Gaps = 57/432 (13%)
Query: 548 LTGDGLNGPSDASEQRVSMASSGSS---QP--ELVTIPLIKGP-KGFGFAIADSP-TGQK 600
+T D L+GP S S + S +P E+V + L + P +GFGF I + +GQ
Sbjct: 740 MTWDSLSGPPVQSMHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQA 799
Query: 601 VKMILDSQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLI 652
I S G ++ G I + H +++ T V +++ P ++ +
Sbjct: 800 DPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQ 859
Query: 653 LRG-GPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSI----------------- 694
+G G +P D+++N+ + ++ + S+
Sbjct: 860 SKGVGGNNP--------DEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMA 911
Query: 695 -IRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLD------VFLRKQESGFGFRVLGGDG-- 745
++S P+L +L K PP+ ++ V L K++ GF V GG
Sbjct: 912 GVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTS 971
Query: 746 -PDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLL 804
P IY+ +I+P G A K+G++ D L+ +DG+ + G +HKQ + +T + ++L
Sbjct: 972 VPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVL 1031
Query: 805 TVRRKIFYGEKQPEDDS---SQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENE- 860
R + +DS + +S P + V P+ ++V L++ N
Sbjct: 1032 ERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPK--FEVKLKKNANGL 1089
Query: 861 GFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIV 920
GF FV + ++ +I R+ G PA+ G + GD I AVNG+S L ++
Sbjct: 1090 GFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVL 1149
Query: 921 QLIKDAGVTVTL 932
L++ A VTL
Sbjct: 1150 HLLRGAPQEVTL 1161
Score = 69.7 bits (169), Expect = 1e-11
Identities = 75/288 (26%), Positives = 127/288 (44%), Gaps = 23/288 (7%)
Query: 827 STQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSK--NKPPPGVIPHKIGR 884
S GS R A P +E V L+R + GFGFVI + + PG+ I
Sbjct: 752 SMHAGSKNNRRKSFIAEPG-REIVRVTLKRDPHRGFGFVINEGEYSGQADPGIF---ISS 807
Query: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHG-- 942
+I G PA++ +K G I A+N S+ + + V++I+++ + L + + G
Sbjct: 808 IIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNN 867
Query: 943 PPSGTNSARQSPA-----LQHRPMGQSQANHIPGDRSALEGEIG--KDVSTSYRHSWSDH 995
P NS S L G ++ DR+ E ++ + + RH S
Sbjct: 868 PDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLS-- 925
Query: 996 KHLAQPDTAVISVVGSRHNQNLG-CYPVELERGPRGFGFSLRGGKEYNM---GLFILRLA 1051
A S S + G Y VEL + GFS+ GG ++ G+++ +
Sbjct: 926 --FLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIV 983
Query: 1052 EDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
GPA K+G+I GD++++++G G+TH +A++ + G L+L
Sbjct: 984 PGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVL 1031
Score = 65.1 bits (157), Expect = 4e-10
Identities = 90/438 (20%), Positives = 166/438 (37%), Gaps = 103/438 (23%)
Query: 730 RKQESGFGFRVLGGD---GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
R GFGF + G+ D I+I +IIP G AEK ++ +++ ++ I ++G +
Sbjct: 780 RDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTF 839
Query: 787 KQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFIS------------------- 827
+ ++ + N ++++ + + G P+++ + S
Sbjct: 840 NMAVRMIQNSPDNIELIISQSKGV--GGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSH 897
Query: 828 ---------------TQNGSPRLNR--AEVPARPA----PQEPYDV-------VLQRKEN 859
Q+ PRL + +P + A P P ++ V KE+
Sbjct: 898 TQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKED 957
Query: 860 EGFGFVILTSKNKPPP--GVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHD 917
GF + N P G+ + ++ G PA + G++ GD + V+G + L+H
Sbjct: 958 GTLGFSVTGGINTSVPYGGIY---VKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHK 1014
Query: 918 NIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALE 977
VQ + G L + E P S + ++ S +PG
Sbjct: 1015 QAVQCLTGPGQVARLVL----ERRVPRSTQQCPSANDSMGDERTAVSLVTALPG------ 1064
Query: 978 GEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRG 1037
+P + V G + + V+L++ G GFS
Sbjct: 1065 ----------------------RPSSCVSVTDGPK-------FEVKLKKNANGLGFSFVQ 1095
Query: 1038 GKEYNMG------LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAG 1091
++ + + I RL PA ++G I GD I+ +NG T+G+ + L++
Sbjct: 1096 MEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGA 1155
Query: 1092 GNKV-LLLLRPGTGLIPD 1108
+V LLL RP G +P+
Sbjct: 1156 PQEVTLLLCRPPPGALPE 1173
Score = 52.4 bits (124), Expect = 2e-06
Identities = 102/446 (22%), Positives = 180/446 (40%), Gaps = 68/446 (15%)
Query: 388 SKPDMEKSHFTRDPSQLKGVLVRASLKKST-MGFGFTIIGGD---RPDEFLQVKNVLKDG 443
SK + KS F +P + +VR +LK+ GFGF I G+ + D + + +++ G
Sbjct: 757 SKNNRRKS-FIAEPGR---EIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGG 812
Query: 444 PAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGY--PLPDDSE 501
PA + I PG I+ +N + G T V+M Q P N + ++ +G PD+ +
Sbjct: 813 PAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEK 872
Query: 502 DPVVDI-VAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNG------KSGHTLTGDGLN 554
+ + V++T +++ +G + QD L+ G + H L+ L
Sbjct: 873 NSTANSGVSSTDILSFG--YQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLK 930
Query: 555 GPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPT------GQKVKMILD-- 606
G + S+G E+ + L+K GF++ G VK I+
Sbjct: 931 GAGSSCPPSPPEISAG----EIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGG 986
Query: 607 --SQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTA 664
++ Q LQ GD + ++ + LTH Q V+ L V L+L P T+
Sbjct: 987 PAAKEGQILQ-GDRLLQVDGVILCGLTHKQAVQCLTG---PGQVARLVLERRVPRSTQQC 1042
Query: 665 KMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKD 724
D + + ++ +P G P S D P
Sbjct: 1043 PSANDSMGDERTAVSLVTALP------------GRP---------SSCVSVTDGP----K 1077
Query: 725 LDVFLRKQESGFGFRVLGGDGPDQS------IYIGAIIPLGAAEKDGRLRAADELMCIDG 778
+V L+K +G GF + + S + I + P AE++G + A D ++ ++G
Sbjct: 1078 FEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 1137
Query: 779 IPVKGKSHKQVLDLMTTAARNGHVLL 804
+G ++VL L+ A + +LL
Sbjct: 1138 RSTEGLIFQEVLHLLRGAPQEVTLLL 1163
Score = 49.7 bits (117), Expect = 2e-05
Identities = 43/179 (24%), Positives = 81/179 (45%), Gaps = 23/179 (12%)
Query: 406 GVLVRASLKKSTMGFGFTIIGGDRPD------EFLQVKNVLKDGPAAQDGKIAPGDVIVD 459
G LKK+ G GF+ + ++ + +++K + PA ++G IA GD+I+
Sbjct: 1075 GPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILA 1134
Query: 460 INGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYP--LPDDSEDPVVDIVAATPVINGQ 517
+NG G +V+ + + P Q V L LCR P LP+ ++ ++A
Sbjct: 1135 VNGRSTEGLIFQEVLHLLRGAP--QEVTLLLCRPPPGALPELEQEWQTPELSADKEFTRA 1192
Query: 518 SLTKGETCMNPQDFKPGAMVLEQNGK---SGHTLTGDGLNGPSDASEQRVSMASSGSSQ 573
+ T ++C +P +L+Q S G+GL ++S++ + A G ++
Sbjct: 1193 TCT--DSCTSP--------ILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNR 1241
Score = 46.2 bits (108), Expect = 2e-04
Identities = 29/88 (32%), Positives = 46/88 (52%), Gaps = 4/88 (4%)
Query: 1022 VELERGP-RGFGFSLRGGK---EYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQ 1077
V L+R P RGFGF + G+ + + G+FI + GPA K I G QI+ +N +
Sbjct: 776 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 835
Query: 1078 GITHTRAIELIQAGGNKVLLLLRPGTGL 1105
G T A+ +IQ + + L++ G+
Sbjct: 836 GFTFNMAVRMIQNSPDNIELIISQSKGV 863
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 81.3 bits (199), Expect = 5e-15
Identities = 78/278 (28%), Positives = 125/278 (44%), Gaps = 26/278 (9%)
Query: 678 EAINEPIPQP-MPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQES-- 734
E +N I +P P P + IR S+ + Y +P + KDL + QE
Sbjct: 412 ERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPP--YYSRPSSHKDLTQCVTCQEKHI 469
Query: 735 --------GFGFRVLGGDGPDQS---IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKG 783
G V GG G I++ ++ P G +DGR++ D L+ I+GI +
Sbjct: 470 TVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529
Query: 784 KSHKQVLDLMTTAARNGHVLLT------VRRKIFYGEKQPEDDSSQAFISTQNGSPRLNR 837
SH + + ++ +A + V L V E+QP S + ++ + S +
Sbjct: 530 LSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPS-WVMW 588
Query: 838 AEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKL 897
+P+ +D+VL+R +GF I+ + P I ++ G+PA G+L
Sbjct: 589 LGLPS--TLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQ-PFFIKTIVLGTPAYYDGRL 645
Query: 898 KVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVI 935
K GD I AVNG S V +SH +V ++K+ VTLTVI
Sbjct: 646 KCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683
Score = 75.1 bits (183), Expect = 3e-13
Identities = 89/399 (22%), Positives = 158/399 (39%), Gaps = 64/399 (16%)
Query: 716 EDKPPNTKDLDVFLRKQESG--FGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADEL 773
+ P + V L K++SG G +++ + ++I ++ G A +DGRL + D +
Sbjct: 329 DSNSPREEIFQVALHKRDSGEQLGIKLVRRTD-EPGVFILDLLEGGLAAQDGRLSSNDRV 387
Query: 774 MCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSP 833
+ I+G +K + + ++ + V LT+ R G+ QP + +A + S
Sbjct: 388 LAINGHDLKYGTPELAAQIIQASGER--VNLTIARP---GKPQPGNTIREA---GNHSSS 439
Query: 834 RLNRAEVPARPAPQEPYD-----------VVLQRKENEGFGFVILTSKNKPPPGVIPHKI 882
+ P P D + ++++ +E G + + G +P +
Sbjct: 440 SQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKS-GELPIFV 498
Query: 883 GRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHG 942
V R G++K GD + +NG + LSH V ++K + + + + A E
Sbjct: 499 TSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIV 558
Query: 943 PPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPD 1002
+ N+ Q + S+ SW L P
Sbjct: 559 EEATQNAEEQPSTFSEN-----------------------EYDASWSPSWV--MWLGLPS 593
Query: 1003 TAVISVVGSRHNQNLGCYPVELERGPRG-FGFSLRGGKEYN---MGLFILRLAEDGPAIK 1058
T H+ C+ + L R G +GFS+ GG E N FI + PA
Sbjct: 594 TL--------HS----CHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYY 641
Query: 1059 DGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLL 1097
DGR+ GD IV +NG T G++H+ + +++ NKV L
Sbjct: 642 DGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTL 680
Score = 72.8 bits (177), Expect = 2e-12
Identities = 87/367 (23%), Positives = 151/367 (41%), Gaps = 64/367 (17%)
Query: 737 GFRVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTT 795
G ++GG + P +I I + G +DGRL A D+++ ++ + SH +++
Sbjct: 246 GISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
Query: 796 AARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQ 855
H LTV R+ +G + A + + SPR +E + V L
Sbjct: 306 PCNTLH--LTVLRERRFGNR--------AHNHSDSNSPR------------EEIFQVALH 343
Query: 856 RKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELS 915
++++ G I + PGV I ++EG A + G+L D + A+NG + +
Sbjct: 344 KRDS-GEQLGIKLVRRTDEPGVF---ILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGT 399
Query: 916 HDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSA 975
+ Q+I+ +G V LT+ G P N+ R+ A H S +H P
Sbjct: 400 PELAAQIIQASGERVNLTI----ARPGKPQPGNTIRE--AGNH---SSSSQHHTP----- 445
Query: 976 LEGEIGKDVSTSYRHSWSDHKHLAQPDTAVIS--VVGSRHNQNLGCYPVELERGPRGFGF 1033
Y S HK L Q T V +++LG + + G
Sbjct: 446 ----------PPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLG---MTVAGG------ 486
Query: 1034 SLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGN 1093
RG K + +F+ + G +DGRI GD ++ ING ++H+ A+ +++A
Sbjct: 487 --RGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAA 544
Query: 1094 KVLLLLR 1100
+ L+
Sbjct: 545 SPAVALK 551
Score = 47.4 bits (111), Expect = 8e-05
Identities = 97/429 (22%), Positives = 171/429 (39%), Gaps = 85/429 (19%)
Query: 394 KSHFTRDPSQLKGVLVRASLKKSTMG--FGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGK 450
++H D + + + + +L K G G ++ D P F + ++L+ G AAQDG+
Sbjct: 323 RAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVF--ILDLLEGGLAAQDGR 380
Query: 451 IAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCR-GYPLPDDSEDPVVDIVA 509
++ D ++ ING+ + T Q+ Q + VNLT+ R G P P ++ + +
Sbjct: 381 LSSNDRVLAINGHDLKYGTPELAAQIIQ--ASGERVNLTIARPGKPQPGNTIREAGNHSS 438
Query: 510 AT------PVINGQSLTKGET-CMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQ 562
++ P + S K T C+ Q+ K + E + G T+ G
Sbjct: 439 SSQHHTPPPYYSRPSSHKDLTQCVTCQE-KHITVKKEPHESLGMTVAG------------ 485
Query: 563 RVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEI 622
GS EL P G + D + +++GD++ I
Sbjct: 486 -----GRGSKSGELPIFVTSVPPHGC--------------LARDGR----IKRGDVLLNI 522
Query: 623 YHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINE 682
++ NL+H + V +LK V L L + + T E S + NE
Sbjct: 523 NGIDLTNLSHSEAVAMLKASAASPAVALKALE------VQIVEEATQNAEEQPSTFSENE 576
Query: 683 PIPQPMPFPPS-IIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESG-FGFRV 740
+ PS ++ G P TL+ D+ LR+ G +GF +
Sbjct: 577 ---YDASWSPSWVMWLGLP-----------STLHSCH-------DIVLRRSYLGSWGFSI 615
Query: 741 LGG---DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAA 797
+GG + +Q +I I+ A DGRL+ D ++ ++G+ G SH ++ ++
Sbjct: 616 VGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPML--KE 673
Query: 798 RNGHVLLTV 806
+ V LTV
Sbjct: 674 QRNKVTLTV 682
Score = 46.6 bits (109), Expect = 1e-04
Identities = 26/60 (43%), Positives = 37/60 (61%), Gaps = 1/60 (1%)
Query: 1044 GLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKV-LLLLRPG 1102
G+FIL L E G A +DGR+ D+++ ING + T A ++IQA G +V L + RPG
Sbjct: 363 GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPG 422
Score = 35.4 bits (80), Expect = 0.31
Identities = 26/94 (27%), Positives = 47/94 (50%), Gaps = 7/94 (7%)
Query: 384 EIGSSKPDMEKS---HFTRDPSQL-KGVLVRASLKKST--MGFGFTIIGGDR-PDEFLQV 436
E G P E+S T+ P L +G + + +S + G +I+GG+ P + +
Sbjct: 203 EPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVI 262
Query: 437 KNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTH 470
+ V +DG A+DG++ GD I+ +N + +H
Sbjct: 263 QEVYRDGVIARDGRLLAGDQILQVNNYNISNVSH 296
Score = 35.4 bits (80), Expect = 0.31
Identities = 28/94 (29%), Positives = 46/94 (48%), Gaps = 6/94 (6%)
Query: 388 SKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGG--DRPDEF-LQVKNVLKDGP 444
S+P K Q K + V+ K+ G T+ GG + E + V +V G
Sbjct: 450 SRPSSHKDLTQCVTCQEKHITVK---KEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGC 506
Query: 445 AAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQ 478
A+DG+I GDV+++ING + +H++ V M +
Sbjct: 507 LARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
>gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens]
Length = 262
Score = 79.0 bits (193), Expect = 2e-14
Identities = 41/89 (46%), Positives = 61/89 (68%), Gaps = 2/89 (2%)
Query: 1014 NQNLGCYPVELERGPRGFGFSLRGGKEY--NMGLFILRLAEDGPAIKDGRIHVGDQIVEI 1071
+Q G + VEL RG GFG +L GG++ + L + L +DGPA + GR+ VGD ++ I
Sbjct: 51 SQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHI 110
Query: 1072 NGEPTQGITHTRAIELIQAGGNKVLLLLR 1100
NGE TQG+TH +A+E I+AGG ++ L++R
Sbjct: 111 NGESTQGLTHAQAVERIRAGGPQLHLVIR 139
Score = 52.4 bits (124), Expect = 2e-06
Identities = 32/84 (38%), Positives = 44/84 (52%), Gaps = 3/84 (3%)
Query: 394 KSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGD--RPDEFLQVKNVLKDGPAAQDGKI 451
K+ PSQ G L + GFG T+ GG D L V+ +LKDGPA + G++
Sbjct: 43 KARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRL 101
Query: 452 APGDVIVDINGNCVLGHTHADVVQ 475
GD+++ ING G THA V+
Sbjct: 102 EVGDLVLHINGESTQGLTHAQAVE 125
Score = 51.6 bits (122), Expect = 4e-06
Identities = 33/114 (28%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 863 GFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQL 922
GF + + G P + +++ PA RCG+L+VGD + +NG+S L+H V+
Sbjct: 67 GFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVER 126
Query: 923 IKDAGVTVTLTVIAE-EEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSA 975
I+ G + L + E H G P G R+ P G + G RS+
Sbjct: 127 IRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGP----EVTGSRSS 176
Score = 33.9 bits (76), Expect = 0.89
Identities = 21/71 (29%), Positives = 36/71 (50%), Gaps = 8/71 (11%)
Query: 578 TIPLIKGPKGFGFAIADS-----PTGQKVKMILD---SQWCQGLQKGDIIKEIYHQNVQN 629
++ L++G GFG + T V+ +L +Q C L+ GD++ I ++ Q
Sbjct: 58 SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 117
Query: 630 LTHLQVVEVLK 640
LTH Q VE ++
Sbjct: 118 LTHAQAVERIR 128
Score = 33.5 bits (75), Expect = 1.2
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 734 SGFGFRVLGGD--GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD 791
+GFG + GG D + + ++ G A++ GRL D ++ I+G +G +H Q ++
Sbjct: 66 AGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 125
Query: 792 LMTTAARNGHVLLTVRRKI 810
+ H L +RR +
Sbjct: 126 RIRAGGPQLH--LVIRRPL 142
>gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens]
Length = 334
Score = 79.0 bits (193), Expect = 2e-14
Identities = 41/89 (46%), Positives = 61/89 (68%), Gaps = 2/89 (2%)
Query: 1014 NQNLGCYPVELERGPRGFGFSLRGGKEY--NMGLFILRLAEDGPAIKDGRIHVGDQIVEI 1071
+Q G + VEL RG GFG +L GG++ + L + L +DGPA + GR+ VGD ++ I
Sbjct: 118 SQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHI 177
Query: 1072 NGEPTQGITHTRAIELIQAGGNKVLLLLR 1100
NGE TQG+TH +A+E I+AGG ++ L++R
Sbjct: 178 NGESTQGLTHAQAVERIRAGGPQLHLVIR 206
Score = 55.8 bits (133), Expect = 2e-07
Identities = 38/133 (28%), Positives = 64/133 (48%), Gaps = 9/133 (6%)
Query: 825 FISTQNGSPRLNRAEVPARPAPQEP---YDVVLQRKENEGF-GFVILTSKNKPPPGVIPH 880
++ T N P+L + + + P P + + V L R G+ GF + + G P
Sbjct: 96 WLETCNAPPQLIQGKARSAPKPSQASGHFSVELVR----GYAGFGLTLGGGRDVAGDTPL 151
Query: 881 KIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAE-EE 939
+ +++ PA RCG+L+VGD + +NG+S L+H V+ I+ G + L + E
Sbjct: 152 AVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLET 211
Query: 940 HHGPPSGTNSARQ 952
H G P G R+
Sbjct: 212 HPGKPRGVGEPRK 224
Score = 52.4 bits (124), Expect = 2e-06
Identities = 32/84 (38%), Positives = 44/84 (52%), Gaps = 3/84 (3%)
Query: 394 KSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGD--RPDEFLQVKNVLKDGPAAQDGKI 451
K+ PSQ G L + GFG T+ GG D L V+ +LKDGPA + G++
Sbjct: 110 KARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRL 168
Query: 452 APGDVIVDINGNCVLGHTHADVVQ 475
GD+++ ING G THA V+
Sbjct: 169 EVGDLVLHINGESTQGLTHAQAVE 192
Score = 37.4 bits (85), Expect = 0.081
Identities = 43/168 (25%), Positives = 68/168 (40%), Gaps = 16/168 (9%)
Query: 554 NGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADS-----PTGQKVKMILD-- 606
N P + + A S ++ L++G GFG + T V+ +L
Sbjct: 101 NAPPQLIQGKARSAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDG 160
Query: 607 -SQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAK 665
+Q C L+ GD++ I ++ Q LTH Q VE ++ G + L+I R P T K
Sbjct: 161 PAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIR--AGGPQLHLVIRR---PLETHPGK 215
Query: 666 MKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKL---DPSEVYLK 710
+ + G + + + P P + RS S L PS LK
Sbjct: 216 PRGVGEPRKGVVPSWPDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLK 263
Score = 33.5 bits (75), Expect = 1.2
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 734 SGFGFRVLGGD--GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD 791
+GFG + GG D + + ++ G A++ GRL D ++ I+G +G +H Q ++
Sbjct: 133 AGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 192
Query: 792 LMTTAARNGHVLLTVRRKI 810
+ H L +RR +
Sbjct: 193 RIRAGGPQLH--LVIRRPL 209
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 78.2 bits (191), Expect = 4e-14
Identities = 61/204 (29%), Positives = 97/204 (47%), Gaps = 12/204 (5%)
Query: 727 VFLRKQESGFGFRVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKS 785
V RK+ SG GF V GG D +SI + + GAA ++G + D L+ ++G + G +
Sbjct: 2624 VLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLA 2683
Query: 786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPA 845
H VL ++ A + L+ +++ G QP + Q T NG L+R +P P
Sbjct: 2684 HGNVLKVLHQAQLHKDALVVIKK----GMDQPRPSARQE-PPTANGKGLLSRKTIPLEPG 2738
Query: 846 PQEPYDV-----VLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG 900
V V K + G G + K+ G P I RV +G A++ G ++ G
Sbjct: 2739 IGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVT-GDGPLVIKRVYKGGAAEQAGIIEAG 2797
Query: 901 DHISAVNGQSIVELSHDNIVQLIK 924
D I A+NG+ +V L H + ++K
Sbjct: 2798 DEILAINGKPLVGLMHFDAWNIMK 2821
Score = 77.4 bits (189), Expect = 7e-14
Identities = 95/371 (25%), Positives = 162/371 (43%), Gaps = 67/371 (18%)
Query: 729 LRKQESGFGFRVLGGDGPDQS---IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKS 785
L K+ G G +V GG G +S I + + GAA +DGRL DEL+ I+G + G S
Sbjct: 337 LLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLS 396
Query: 786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPA 845
H++ + ++ +A G V L V K E+ + T P L + V +
Sbjct: 397 HEEAVAILRSAT--GMVQLVVASK--------ENSAEDLLRLTSKSLPDLT-SSVEDVSS 445
Query: 846 PQEPYDVVLQRKENEGFGFVILTSKNKPPPGVI-PHKIGRVIEG-----SPADRCGKLKV 899
+ D +E+EG +S + PG P + E SP K+K+
Sbjct: 446 WTDNEDQEADGEEDEGTS----SSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKL 501
Query: 900 GDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEE-EHHGPPSGTNSARQSPALQH 958
+S G +E + ++++ + + ++ + H P +S+
Sbjct: 502 KSRLSG--GVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSS-------- 551
Query: 959 RPMGQSQANHIPGDRSALEGEIGKDVSTSYRHS-WSDHKHLAQPDTAVISVVGSRHNQNL 1017
SQ HI + + +ST+ S W L +P +VIS++G
Sbjct: 552 ---SASQEYHIVKKST-------RSLSTTQVESPW----RLIRP--SVISIIG------- 588
Query: 1018 GCYPVELERGPRGFGFSLRGGKEY---NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGE 1074
+ E+G +G GFS+ GG++ MG+F+ + +G A +DGR+ GD+I+++NG
Sbjct: 589 ----LYKEKG-KGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643
Query: 1075 PTQGITHTRAI 1085
P +G+T AI
Sbjct: 644 PIKGLTFQEAI 654
Score = 73.2 bits (178), Expect = 1e-12
Identities = 68/242 (28%), Positives = 103/242 (42%), Gaps = 45/242 (18%)
Query: 852 VVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSI 911
+VL RKE G GF + + P + H RV A + G + GD + +VNG S+
Sbjct: 2623 IVLNRKEGSGLGFSVAGGTDVEPKSITVH---RVFSQGAASQEGTMNRGDFLLSVNGASL 2679
Query: 912 VELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPG 971
L+H N+++++ A + V+ ++ G SARQ P + G IP
Sbjct: 2680 AGLAHGNVLKVLHQAQLHKDALVVIKK---GMDQPRPSARQEPPTAN-GKGLLSRKTIP- 2734
Query: 972 DRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGF 1031
LE IG+ V+ H L VE+ + G
Sbjct: 2735 ----LEPGIGRSVAV--------HDALC----------------------VEVLKTSAGL 2760
Query: 1032 GFSLRGGKEYNMG---LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELI 1088
G SL GGK G L I R+ + G A + G I GD+I+ ING+P G+ H A ++
Sbjct: 2761 GLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIM 2820
Query: 1089 QA 1090
++
Sbjct: 2821 KS 2822
Score = 62.0 bits (149), Expect = 3e-09
Identities = 52/203 (25%), Positives = 88/203 (43%), Gaps = 28/203 (13%)
Query: 730 RKQESGFGFRVLGGDG---PDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
+++ G GF + GG I++ I P G+A +DGRL+ DE++ ++GIP+KG +
Sbjct: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650
Query: 787 KQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPA---- 842
++ + R+G +LTVR K+ P S +++ SP N + +
Sbjct: 651 QEAIHTF-KQIRSGLFVLTVRTKLVSPSLTP---CSTPTHMSRSASPNFNTSGGASAGGS 706
Query: 843 -----------RPAPQE--PYDVVLQRKENEGFGF-VILTSKNKPPPGVIPHKIGRVIEG 888
P P++ +V L ++ G G + PPG+ H + G
Sbjct: 707 DEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLA---PG 763
Query: 889 SPADRCGKLKVGDHISAVNGQSI 911
S A L GD I VN ++
Sbjct: 764 SVAKMESNLSRGDQILEVNSVNV 786
Score = 59.7 bits (143), Expect = 2e-08
Identities = 88/396 (22%), Positives = 153/396 (38%), Gaps = 69/396 (17%)
Query: 414 KKSTMGFGFTIIGGD---RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTH 470
K+ G GF+I GG R + VK + +G AA+DG++ GD I+D+NG + G T
Sbjct: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650
Query: 471 ADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQD 530
+ + F+ + +V + T +++ SLT C P
Sbjct: 651 QEAIHTFKQIRSGLFV--------------------LTVRTKLVS-PSLT---PCSTPTH 686
Query: 531 FKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPK-GFG 589
A + +T G G + S + + G ++ + L K P+ G G
Sbjct: 687 MSRSA------SPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLG 740
Query: 590 -----FAIADSPTGQKVKMILDSQWCQ---GLQKGDIIKEIYHQNVQNLTHLQVVEVLKQ 641
A+ +SP G + + + L +GD I E+ NV++ +V +L +
Sbjct: 741 IGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSK 800
Query: 642 FPVGADVPLLILRGGPPSPTKT--------AKMKTDKKENAGSLEAINEPIPQPMPFPPS 693
P G P+ ++ G P+P + A+ + + A S + P+ PS
Sbjct: 801 CPPG---PVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKS-----PS 852
Query: 694 IIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIG 753
+ + S + SE+ S+ D P D V + E G G + G
Sbjct: 853 LAKKDS-LISESEL---SQYFAHDVPGPLSDFMVAGSEDEDHPG----SGCSTSEE---G 901
Query: 754 AIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQV 789
++ P + K+ A+ L+ + G HKQV
Sbjct: 902 SLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQV 937
Score = 52.0 bits (123), Expect = 3e-06
Identities = 56/239 (23%), Positives = 97/239 (40%), Gaps = 45/239 (18%)
Query: 583 KGPKGFGFAIADSPTGQKVKMILDSQWCQG-------LQKGDIIKEIYHQNVQNLTHLQV 635
K G GF++A + + + + QG + +GD + + ++ L H V
Sbjct: 2628 KEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNV 2687
Query: 636 VEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSII 695
++VL Q + D L++++ G P +A+ + G L + +P P I
Sbjct: 2688 LKVLHQAQLHKDA-LVVIKKGMDQPRPSARQEPPTANGKGLLSR------KTIPLEPGIG 2740
Query: 696 RSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLG------GDGPDQS 749
RS + L V + K +G G + G GDGP
Sbjct: 2741 RSVAVH---------------------DALCVEVLKTSAGLGLSLDGGKSSVTGDGP--- 2776
Query: 750 IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRR 808
+ I + GAAE+ G + A DE++ I+G P+ G H ++M + G V L +R+
Sbjct: 2777 LVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVP-EGPVQLLIRK 2834
Score = 47.8 bits (112), Expect = 6e-05
Identities = 29/114 (25%), Positives = 55/114 (48%), Gaps = 11/114 (9%)
Query: 414 KKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHAD 472
+K G GF++ GG D + + V V G A+Q+G + GD ++ +NG + G H +
Sbjct: 2627 RKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGN 2686
Query: 473 VVQMFQLVPVNQYVNLTLCRG--YPLPDDSEDPVVDIVAATPVINGQSLTKGET 524
V+++ +++ + + +G P P ++P P NG+ L +T
Sbjct: 2687 VLKVLHQAQLHKDALVVIKKGMDQPRPSARQEP--------PTANGKGLLSRKT 2732
Score = 45.8 bits (107), Expect = 2e-04
Identities = 23/83 (27%), Positives = 46/83 (55%), Gaps = 3/83 (3%)
Query: 1020 YPVELERGPRGFGFSLRGG---KEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
+ +EL + G G + GG K + + ++ E G A +DGR+ +GD+++ ING
Sbjct: 333 WKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL 392
Query: 1077 QGITHTRAIELIQAGGNKVLLLL 1099
G++H A+ ++++ V L++
Sbjct: 393 VGLSHEEAVAILRSATGMVQLVV 415
Score = 41.6 bits (96), Expect = 0.004
Identities = 26/70 (37%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 415 KSTMGFGFTIIGGDRP---DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471
K++ G G ++ GG D L +K V K G A Q G I GD I+ ING ++G H
Sbjct: 2755 KTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHF 2814
Query: 472 DVVQMFQLVP 481
D + + VP
Sbjct: 2815 DAWNIMKSVP 2824
Score = 39.7 bits (91), Expect = 0.016
Identities = 22/76 (28%), Positives = 41/76 (53%), Gaps = 3/76 (3%)
Query: 406 GVLVRASLKKSTMGFGFTIIGG---DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDING 462
G + + L K + G G + GG R + V V + G A +DG+++ GD ++ ING
Sbjct: 330 GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
Query: 463 NCVLGHTHADVVQMFQ 478
+ ++G +H + V + +
Sbjct: 390 HLLVGLSHEEAVAILR 405
Score = 33.1 bits (74), Expect = 1.5
Identities = 23/82 (28%), Positives = 44/82 (53%), Gaps = 12/82 (14%)
Query: 1031 FGFSLRGGKE--------YNMG-LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
+G RGGK+ ++G +++ L ++ PA K G++ + D+I+ +NG+ G+
Sbjct: 96 YGEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDV 155
Query: 1082 TRAIELIQA---GGNKVLLLLR 1100
+ A L + GG L++LR
Sbjct: 156 SGASYLAEQCWNGGFIYLIMLR 177
Score = 32.3 bits (72), Expect = 2.6
Identities = 13/37 (35%), Positives = 23/37 (62%)
Query: 68 GDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVK 104
GD +L+VNG P+ GLT ++ + + R + + TV+
Sbjct: 634 GDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVR 670
Score = 30.4 bits (67), Expect = 9.9
Identities = 25/97 (25%), Positives = 47/97 (48%), Gaps = 12/97 (12%)
Query: 887 EGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDA--GVTVTLTVIAEEEH--HG 942
+ SPA + GK+++ D I ++NGQ +V + L + G + L ++ +H H
Sbjct: 126 KNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFKHKAHS 185
Query: 943 PPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGE 979
+G +S P G++ + GDR+A +G+
Sbjct: 186 TYNGNSSNSSEP-------GETPTLEL-GDRTAKKGK 214
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.135 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,987,317
Number of Sequences: 37866
Number of extensions: 2729218
Number of successful extensions: 10113
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 243
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 7813
Number of HSP's gapped (non-prelim): 1825
length of query: 1125
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1012
effective length of database: 13,968,660
effective search space: 14136283920
effective search space used: 14136283920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.