Guide to the Human Genome
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Search of human proteins with 154800453

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|154800453 tastin isoform 1 [Homo sapiens]
         (778 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|154800453 tastin isoform 1 [Homo sapiens]                         1605   0.0  
gi|154800455 tastin isoform 2 [Homo sapiens]                          234   2e-61
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...    67   8e-11
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    61   5e-09
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    61   5e-09
gi|47132519 Ras association and pleckstrin homology domains 1 is...    61   5e-09
gi|68563515 keratinocyte proline-rich protein [Homo sapiens]           61   5e-09
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   60   1e-08
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   60   1e-08
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   60   1e-08
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    60   1e-08
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    59   1e-08
gi|119943102 CREB binding protein isoform b [Homo sapiens]             58   4e-08
gi|119943104 CREB binding protein isoform a [Homo sapiens]             58   4e-08
gi|41281612 zinc finger protein 828 [Homo sapiens]                     57   9e-08
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    55   2e-07
gi|150170670 piccolo isoform 2 [Homo sapiens]                          54   4e-07
gi|150378539 piccolo isoform 1 [Homo sapiens]                          54   4e-07
gi|62000702 diacylglycerol kinase kappa [Homo sapiens]                 54   6e-07
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    54   6e-07
gi|153792074 proline rich 12 [Homo sapiens]                            54   6e-07
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    53   9e-07
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...    53   1e-06
gi|236459851 ubinuclein 2 [Homo sapiens]                               52   2e-06
gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]                52   2e-06
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [...    51   5e-06
gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]       50   6e-06
gi|110349719 titin isoform N2-A [Homo sapiens]                         50   8e-06
gi|14602439 Williams Beuren syndrome chromosome region 14 isofor...    49   2e-05
gi|14602437 Williams Beuren syndrome chromosome region 14 isofor...    49   2e-05

>gi|154800453 tastin isoform 1 [Homo sapiens]
          Length = 778

 Score = 1605 bits (4155), Expect = 0.0
 Identities = 778/778 (100%), Positives = 778/778 (100%)

Query: 1   MTTRQATKDPLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQR 60
           MTTRQATKDPLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQR
Sbjct: 1   MTTRQATKDPLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQR 60

Query: 61  PLVDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQTEAPGTIEF 120
           PLVDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQTEAPGTIEF
Sbjct: 61  PLVDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQTEAPGTIEF 120

Query: 121 VADPAALATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTH 180
           VADPAALATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTH
Sbjct: 121 VADPAALATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTH 180

Query: 181 RLDPARASCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRT 240
           RLDPARASCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRT
Sbjct: 181 RLDPARASCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRT 240

Query: 241 SVSQASGLLLETPVQPAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSH 300
           SVSQASGLLLETPVQPAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSH
Sbjct: 241 SVSQASGLLLETPVQPAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSH 300

Query: 301 DSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPM 360
           DSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPM
Sbjct: 301 DSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPM 360

Query: 361 PSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPH 420
           PSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPH
Sbjct: 361 PSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPH 420

Query: 421 SNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLN 480
           SNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLN
Sbjct: 421 SNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLN 480

Query: 481 ATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQE 540
           ATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQE
Sbjct: 481 ATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQE 540

Query: 541 QLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIP 600
           QLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIP
Sbjct: 541 QLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIP 600

Query: 601 ESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPP 660
           ESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPP
Sbjct: 601 ESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPP 660

Query: 661 CCSQWAPATTSLIFSSQHPLCASPPICSLQSLRPPAGQAGLSNLAPRTLALRERLKSCLT 720
           CCSQWAPATTSLIFSSQHPLCASPPICSLQSLRPPAGQAGLSNLAPRTLALRERLKSCLT
Sbjct: 661 CCSQWAPATTSLIFSSQHPLCASPPICSLQSLRPPAGQAGLSNLAPRTLALRERLKSCLT 720

Query: 721 AIHCFHEARLDDECAFYTSRAPPSGPTRVCTNPVATLLEWQDALCFIPVGSAAPQGSP 778
           AIHCFHEARLDDECAFYTSRAPPSGPTRVCTNPVATLLEWQDALCFIPVGSAAPQGSP
Sbjct: 721 AIHCFHEARLDDECAFYTSRAPPSGPTRVCTNPVATLLEWQDALCFIPVGSAAPQGSP 778


>gi|154800455 tastin isoform 2 [Homo sapiens]
          Length = 144

 Score =  234 bits (597), Expect = 2e-61
 Identities = 115/121 (95%), Positives = 116/121 (95%), Gaps = 3/121 (2%)

Query: 1   MTTRQATKDPLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQR 60
           MTTRQATKDPLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQR
Sbjct: 1   MTTRQATKDPLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQR 60

Query: 61  PLVDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQT---EAPGT 117
           PLVDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQT    APG 
Sbjct: 61  PLVDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQTVLVPAPGK 120

Query: 118 I 118
           +
Sbjct: 121 L 121


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 98/397 (24%), Positives = 124/397 (31%), Gaps = 112/397 (28%)

Query: 305 MPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTP 364
           MP P P   PLP    P P P G     P   PP  T  S LRR    PK R   +    
Sbjct: 1   MPVPPPPPPPLP----PPPPPLGAPPPPPPSAPPVSTDTSSLRR--ADPKGRSALLAD-- 52

Query: 365 RVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRT 424
            +QQ   LR V+  +    P                 I S +G+ K    + +   ++  
Sbjct: 53  -IQQGTRLRKVTQINDRSAPQ----------------IESSKGTNKEGGGSANTRGASTP 95

Query: 425 PSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQ------PLLTEISRT 478
           P+L ++      +L+   +++V G   GQ      GS      L       PL+   S  
Sbjct: 96  PTLGDLFAGGFPVLRPAGQRDVAGGKTGQ----GPGSRAPSPRLPNKTISGPLIPPASPR 151

Query: 479 LNATEHNSGTSHL---------------------------------------PGLLKHSG 499
           L  T    G +                                         PG L    
Sbjct: 152 LGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGN 211

Query: 500 LPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPE-------PYPPAE 552
           LP    P  C  P P PP  P PP       P  P   L ++   P+       P PP  
Sbjct: 212 LPVVAPPVPCAPPPPPPPPPPTPP-------PLPPASVLSDKAVKPQLAPLHLPPIPP-- 262

Query: 553 PRPLESCC-----RSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEI-----PES 602
           P PL   C     ++EP  P    QE        PPA P PL  Y    P       P  
Sbjct: 263 PLPLLPPCGYPGLKAEPASPAQDAQE--------PPAPPPPLPPYASCSPRASLPAPPLP 314

Query: 603 SRQEQLEVPEPCPPAEPG----PLQPSTQGQSGPPGP 635
                 E P P PP  P     P +   Q    PP P
Sbjct: 315 GVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAP 351


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 159/659 (24%), Positives = 215/659 (32%), Gaps = 151/659 (22%)

Query: 63  VDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQTEAPGTIEFVA 122
           +  + PR      A TS R        NP      S RG+     PPA+  +PG +   +
Sbjct: 70  IPESAPRAGPTRSAGTSSR--------NPASRPPASGRGERA---PPAKNTSPGPVS--S 116

Query: 123 DPAALATILSGE-GVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTHR 181
              A  T   G  G K   +  + ++A+       +          R ++   P TP+  
Sbjct: 117 PGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALS-AGARRDTSGPTPGTPSPA 175

Query: 182 LDPARASCFSR--LEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSR 239
           +     +  +   L  P P  R   P       S S  S H +T PS    RR +AG   
Sbjct: 176 MARRSRAAGTEVGLPRPAPSARPRPPTEGPRK-SVSSASEHSTTEPSPAARRRPSAGGGL 234

Query: 240 TSVSQASGLLLETPVQ-PAFSLP--KGEREVVTHSDEG---GVASLGLAQRVPLRENREM 293
              +  S     TP+  PA S P  +G      H  +    G+ +L   Q  P R++   
Sbjct: 235 QRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDA-- 292

Query: 294 SHTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQP 353
                          AP   PL    +  PSP    Q   S  PPTL +      LT Q 
Sbjct: 293 ---------------APALGPLSSSPLATPSPSAALQ---SQAPPTLPATPHSSSLTCQ- 333

Query: 354 KTRFTPMPSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQ--ESCIRSLEGSGKP 411
               TP+P  P    A      S Q+    PA P  Q    L     ++    L      
Sbjct: 334 --LATPLPLAPPSPSAP----PSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLS 387

Query: 412 PVAT--PSGPHSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQ 469
           P+AT  P  P +   P LQ                           P +  +S     L 
Sbjct: 388 PLATPPPQAPPALALPPLQ--------------------------APPSPPAS---PPLS 418

Query: 470 PLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECG-EPQPCPPAEPG--PPEAF 526
           PL T   +  NA   +        LL+    P P  P +    P   PP  P   PP   
Sbjct: 419 PLATPSPQAPNALAVH--------LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPS-- 468

Query: 527 CRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEP 586
            ++ P +  P LQ    VP P PPA P P+       P+ P       L++ +P P A P
Sbjct: 469 -QAPPSLAAPPLQ----VP-PSPPASP-PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPP 521

Query: 587 R----------------------------PLESYCRIEPEIPESSRQEQLEVPEPCPPAE 618
                                        P+       P+ P       L+VP P PPA 
Sbjct: 522 ALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVP-PSPPAS 580

Query: 619 P---GPLQPSTQGQ----SGP-------PGPCPRVELGASE----PCTLEHRSLESSLP 659
           P    P +P T G     SGP       PGP P      S     P    H S  +S P
Sbjct: 581 PTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTP 639



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 139/579 (24%), Positives = 189/579 (32%), Gaps = 113/579 (19%)

Query: 106 PGPPAQTEAPGTIEFVADPAALATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQ 165
           P PP     P  +     PAAL  +L   G     +GR+P LA+R    G  GG T    
Sbjct: 27  PRPPGSPRPPPPVT----PAALR-VLGAAGA----VGRKP-LAERA---GGIGGATIPES 73

Query: 166 GVRA----SAYLAPRTPT---------HRLDPARASCFSRLEGPGPRGRTLCPQRLQALI 212
             RA    SA  + R P           R  PA+ +    +  PG    T  P       
Sbjct: 74  APRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRP------- 126

Query: 213 SPSGPSFHPSTRPSFQEL---RRETAGSSRTSVSQASGLLLETPVQPAFSLPKGEREVVT 269
              GP      R S +E     + T    R+++S  +      P     S     R    
Sbjct: 127 ---GPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAA 183

Query: 270 HSDEGGVASLGLAQRVPLRENREMSHTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRA 329
            ++ G       A+  P  E    S +  S  S   PSPA   +P  G  +  P+    +
Sbjct: 184 GTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 243

Query: 330 QRVPSPGPPTLTSYSVLRRLTVQPKTRFTPM----PSTPRVQQAQWLRG--VSPQSCSED 383
                   P  +           P  R TP     PS P+ +  Q LR   V+P      
Sbjct: 244 SSATPLSSPARSG----------PSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAA 293

Query: 384 PAL-PWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRTPSLQEVKIQRIGILQQLL 442
           PAL P     +      + ++S     + P   P+ PHS+              +  QL 
Sbjct: 294 PALGPLSSSPLATPSPSAALQS-----QAPPTLPATPHSS-------------SLTCQLA 335

Query: 443 RQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPK 502
                       +PL   S      LQ L +  +   +    + G+  L     HS LP 
Sbjct: 336 TP----------LPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQAT--HSFLPS 383

Query: 503 PCLPEECGEPQPCPPA--------EPGPPEAFCRSEPEIPEPSLQEQLEV---------- 544
           P L      P   PPA         P PP +   S    P P     L V          
Sbjct: 384 PPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 443

Query: 545 PEP------YPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPE 598
           P P       PPA P P+        + P S     L+VP P PPA P P+       P+
Sbjct: 444 PSPPVQAPFSPPASP-PVSPSATPPSQAPPSLAAPPLQVP-PSPPASP-PMSPSATPPPQ 500

Query: 599 IPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCP 637
            P       L++ +P P A P    P  Q    PP   P
Sbjct: 501 APPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP 539


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 150/627 (23%), Positives = 211/627 (33%), Gaps = 110/627 (17%)

Query: 65  SAGPRPKARHQAETSQRLVGISQPR-NPLEELRPSPRGQNVGPGPPAQTEAPGTIEFVAD 123
           + G +P A          +  S PR  P    RP   G+     PPA+  +PG +   + 
Sbjct: 52  AVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPASGRGER-APPAKNTSPGPVS--SP 108

Query: 124 PAALATILSGE-GVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTHRL 182
             A  T   G  G K   +  + ++A+       +          R ++   P TP+  +
Sbjct: 109 GRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALS-AGARRDTSGPTPGTPSPAM 167

Query: 183 DPARASCFSR--LEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRT 240
                +  +   L  P P  R   P       S S  S H +T PS    RR +AG    
Sbjct: 168 ARRSRAAGTEVGLPRPAPSARPRPPTEGPRK-SVSSASEHSTTEPSPAARRRPSAGGGLQ 226

Query: 241 SVSQASGLLLETPV-QPAFSLP--KGEREVVTHSDE---GGVASLGLAQRVPLRENREMS 294
             +  S     TP+  PA S P  +G      H  +    G+ +L   Q  P R      
Sbjct: 227 RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR------ 280

Query: 295 HTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSP--GPPTLTSYSVLRRLTVQ 352
             +D+  +    S +P+A P P    P PS     Q +PSP   PP+  + S L   T+Q
Sbjct: 281 --KDAAPALGPLSSSPLATPSPS-APPSPSAPPSLQTLPSPPATPPSQATTS-LGSPTLQ 336

Query: 353 PKTRFTPMPSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPP 412
               F P P             +SP +     A P              +  L+    PP
Sbjct: 337 ATHSFLPSPP------------LSPLATPPPQAPP-----------ALALPPLQAPPSPP 373

Query: 413 VATPSGPHSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLL 472
            + P  P +  TPS Q      + +LQ                P +   S       P+ 
Sbjct: 374 ASPPLSPLA--TPSPQAPNALAVHLLQ---------------APFSPPPS------PPVQ 410

Query: 473 TEISRTLNATEHNSGT--SHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSE 530
              S   +     S T  S  P  L    L  P          P PPA P P        
Sbjct: 411 APFSPPASPPVSPSATPPSQAPPSLAAPPLQVP----------PSPPASP-PMSPSATPP 459

Query: 531 PEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLE 590
           P+ P P     L++ +P P A P       ++ P  P S   +      P  P+   P+ 
Sbjct: 460 PQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQ-----APFSPSASLPMS 514

Query: 591 SYCRIEPEIPESSRQEQLEVPEPCPPAEP---GPLQPSTQGQ----SGP-------PGPC 636
                 P+ P       L+VP P PPA P    P +P T G     SGP       PGP 
Sbjct: 515 PLATPPPQAPPVLAAPLLQVP-PSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPP 573

Query: 637 PRVELGASE----PCTLEHRSLESSLP 659
           P      S     P    H S  +S P
Sbjct: 574 PPPSRSPSSTLSGPDLAGHSSSATSTP 600



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 129/553 (23%), Positives = 175/553 (31%), Gaps = 100/553 (18%)

Query: 106 PGPPAQTEAPGTIEFVADPAALATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQ 165
           P PP     P  +     PAAL  +L   G     +GR+P LA+R    G  GG T    
Sbjct: 27  PRPPGSPRPPPPVT----PAALR-VLGAAGA----VGRKP-LAERA---GGIGGATIPES 73

Query: 166 GVRASAYLAPRTPT----HRLDPARASCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHP 221
             RA      R P      R  PA+ +    +  PG    T  P          GP    
Sbjct: 74  APRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRP----------GPLGQK 123

Query: 222 STRPSFQEL---RRETAGSSRTSVSQASGLLLETPVQPAFSLPKGEREVVTHSDEGGVAS 278
             R S +E     + T    R+++S  +      P     S     R     ++ G    
Sbjct: 124 GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRP 183

Query: 279 LGLAQRVPLRENREMSHTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPP 338
              A+  P  E    S +  S  S   PSPA   +P  G  +  P+    +        P
Sbjct: 184 APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 243

Query: 339 TLTSYSVLRRLTVQPKTRFTPM-PSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFD 397
             +           P  R TP  P+ P   + + L+ + P            QV     D
Sbjct: 244 ARSG----------PSARGTPRAPAHPSQPKPKGLQALRPP-----------QVTPPRKD 282

Query: 398 QESCIRSLEGSGKPPVATPSG---PHSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQC 454
               +  L  S   P+ATPS    P  +  PSLQ +                        
Sbjct: 283 AAPALGPLSSS---PLATPSPSAPPSPSAPPSLQTLPSPPA------------------T 321

Query: 455 VPLNGGSSLDMVELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQP 514
            P    +SL            S TL AT     +  L  L        P L     +  P
Sbjct: 322 PPSQATTSLG-----------SPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPP 370

Query: 515 CPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEP----------RPLESCCRSEP 564
            PPA P P        P+ P       L+ P   PP+ P           P+        
Sbjct: 371 SPPASP-PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPS 429

Query: 565 EIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQP 624
           + P S     L+VP P PPA P P+       P+ P       L++ +P P A P    P
Sbjct: 430 QAPPSLAAPPLQVP-PSPPASP-PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATP 487

Query: 625 STQGQSGPPGPCP 637
             Q    PP   P
Sbjct: 488 PLQALPSPPASFP 500



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 64/256 (25%), Positives = 85/256 (33%), Gaps = 49/256 (19%)

Query: 473 TEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPE--AFCRSE 530
           T +S    +     GT   P    H   PKP   +    PQ  PP +   P       S 
Sbjct: 238 TPLSSPARSGPSARGTPRAPA---HPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSP 294

Query: 531 PEIPEPSLQEQLEVPE-----PYPPAEP----------------------RPLESCCRSE 563
              P PS       P      P PPA P                       PL       
Sbjct: 295 LATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP 354

Query: 564 PEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEP--GP 621
           P+ P +     L+ P P PPA P PL       P+ P +     L+ P   PP+ P   P
Sbjct: 355 PQAPPALALPPLQAP-PSPPASP-PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAP 412

Query: 622 LQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQHPLC 681
             P       P    P     +  P +L    L+  +PP      PA+  +  S+  P  
Sbjct: 413 FSPPASPPVSPSATPP-----SQAPPSLAAPPLQ--VPPS----PPASPPMSPSATPPPQ 461

Query: 682 ASPPICS--LQSLRPP 695
           A PP+ +  LQ  +PP
Sbjct: 462 APPPLAAPPLQLAKPP 477



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 63/225 (28%), Positives = 77/225 (34%), Gaps = 49/225 (21%)

Query: 499 GLPKPCLPE-------ECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLE--VPEPYP 549
           G P P +         E G P+P P A P PP        E P  S+    E    EP P
Sbjct: 161 GTPSPAMARRSRAAGTEVGLPRPAPSARPRPP-------TEGPRKSVSSASEHSTTEPSP 213

Query: 550 PAEPRPLESCCRSEPEIPE-SSRQEQLEVPE---PCPPAEPRPLESYCRIEPEIPESSRQ 605
            A  RP        P     SS    L  P    P     PR         P  P+    
Sbjct: 214 AARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPR-----APAHPSQPKPKGL 268

Query: 606 EQLEVPEPCPPAEP-----GPLQPS---TQGQSGPPGPCPRVELGASEPCTLEHRSLESS 657
           + L  P+  PP +      GPL  S   T   S PP P        S P +L+      +
Sbjct: 269 QALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSP--------SAPPSLQTLPSPPA 320

Query: 658 LPPCCSQWAPATTSL---IFSSQHPLCASPPICSLQSLRPPAGQA 699
            PP     + ATTSL      + H    SPP+  L +  P A  A
Sbjct: 321 TPP-----SQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPA 360


>gi|47132519 Ras association and pleckstrin homology domains 1
           isoform 1 [Homo sapiens]
          Length = 1250

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 63/239 (26%), Positives = 93/239 (38%), Gaps = 19/239 (7%)

Query: 475 ISRTLNATEHNSGTSHLPGL-LKHSGLPKPCL---PEECGEPQPCPPAEPGPPEAFCRSE 530
           I+R  NA++H+      P   +  S   KP +   P     P P PP  P P  A  + +
Sbjct: 670 ITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLK 729

Query: 531 PEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPP-AEPRPL 589
           P    PSL    +   P PP +   ++   +  P  P         +P P PP A P+PL
Sbjct: 730 PAPCAPSLP---QFSAPPPPLKIHQVQHITQVAPPTPPPPP----PIPAPLPPQAPPKPL 782

Query: 590 ESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTL 649
            +          +    Q   P P PP  P   QP+      PP P P   +    P   
Sbjct: 783 VTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSP-PTPPVPVPPPTLP 841

Query: 650 EHRSLESSLPPCCSQWAPATTSLIFSSQHPLCASPPICSLQSLRPPAGQAGLSNLAPRT 708
           + +S  +  PP      P+    I +SQ P   +PP    Q L+P       +N+AP++
Sbjct: 842 KQQSFCAKPPPSPLSPVPSVVKQI-ASQFPPPPTPPAMESQPLKPVP-----ANVAPQS 894



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 103/437 (23%), Positives = 143/437 (32%), Gaps = 82/437 (18%)

Query: 299  SHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGP--PTLTSYSVLRRL-TVQPKT 355
            S  S  +P P P   P P    P P P   +Q  PS G   P    YS + RL      +
Sbjct: 622  SQPSPPLPPPPPPPPPPPPPPPPPPPPLP-SQSAPSAGSAAPMFVKYSTITRLQNASQHS 680

Query: 356  RFTPMPSTPRVQQAQWLRG---VSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPP 412
                 P TP V Q+Q ++    V P      P  P                S     KP 
Sbjct: 681  GALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP---------PPPPTPGSAMAQLKPA 731

Query: 413  VATPSGPHSNRTPSLQEVKIQRIGILQQLLRQE------VEGLVGGQCVPLNGGSSLDMV 466
               PS P  +  P    +KI ++  + Q+          +   +  Q  P          
Sbjct: 732  PCAPSLPQFSAPPP--PLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPP---------- 779

Query: 467  ELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAF 526
              +PL+T  + T   T     T   P        P P  P    + QP  PA   PP   
Sbjct: 780  --KPLVTIPAPTSTKTVAPVVTQAAP--------PTPTPPVPPAKKQPAFPASYIPPSPP 829

Query: 527  CRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRS-EPEIPESSRQEQLEVPEPCPPA- 584
                P +P P+L +Q       PP+   P+ S  +    + P          P P PPA 
Sbjct: 830  TPPVP-VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFP----------PPPTPPAM 878

Query: 585  -----EPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRV 639
                 +P P     +  P +    + +   +P P P   P P + S      PP P P  
Sbjct: 879  ESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAP 938

Query: 640  -------------ELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSS---QHPLCAS 683
                         + G+    T +  S     PP      P   S I SS   +HP    
Sbjct: 939  PPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPP----TPQRNSSIKSSSGAEHPEPKR 994

Query: 684  PPICSLQSLRPPAGQAG 700
            P + SL S   P  ++G
Sbjct: 995  PSVDSLVSKFTPPAESG 1011



 Score = 34.3 bits (77), Expect = 0.45
 Identities = 72/312 (23%), Positives = 105/312 (33%), Gaps = 48/312 (15%)

Query: 302  SHLMPSPAPVA------QPLPGHVVPCPSPFGRAQR--------VPSPGPPTLTSYSVLR 347
            S   P P P A      +P+P +V P   P  +A+         VPSP  P     S L 
Sbjct: 867  SQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLV 926

Query: 348  RLTVQPKTRFTPMPSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEG 407
                 P     P P  P        +  SP   +   + P  +       + S I+S  G
Sbjct: 927  FPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSG 986

Query: 408  SGKPPVATPSGPH--SNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDM 465
            +  P    PS     S  TP  +     +            E L      P  G  +L  
Sbjct: 987  AEHPEPKRPSVDSLVSKFTPPAESGSPSK------------ETLPPPAAPPKPGKLNLSG 1034

Query: 466  VELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAE-PGPPE 524
            V L  +L +   +  A         L G  K S +  P  P +   P P P  E P PP 
Sbjct: 1035 VNLPGVLQQGCVSAKAPV-------LSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPI 1087

Query: 525  AFC-----RSEPEI----PEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQL 575
                     + P++    P+P    ++ V +  PP  P+  +S   ++ EI   S Q  +
Sbjct: 1088 EIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEI---SEQPTM 1144

Query: 576  EVPEPCPPAEPR 587
                P  P  P+
Sbjct: 1145 ATVVPQVPTSPK 1156



 Score = 30.0 bits (66), Expect = 8.6
 Identities = 49/204 (24%), Positives = 77/204 (37%), Gaps = 19/204 (9%)

Query: 174  APRTPTHRLDPARASCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRE 233
            A  TP     P + +  S+   PG +     PQR  ++ S SG       RPS   L   
Sbjct: 946  ASPTPDKSGSPGKKT--SKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSL--- 1000

Query: 234  TAGSSRTSVSQASGLLLETPVQPAFSLPKGEREVVTHSDEGGVASLG-LAQRVPLRENR- 291
                S+ +    SG   +  + P  + PK  +  ++  +  GV   G ++ + P+   R 
Sbjct: 1001 ---VSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057

Query: 292  ---EMSHTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVP--SPGPPTLTSYSVL 346
                +       DS   P P     PLP   +P       + +V   +P P   +  SV 
Sbjct: 1058 KDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVK 1117

Query: 347  RRLTVQPKTRFTPMPSTPRVQQAQ 370
            +     P TR     ST R+ QA+
Sbjct: 1118 K---APPPTRPKRNDST-RLTQAE 1137


>gi|68563515 keratinocyte proline-rich protein [Homo sapiens]
          Length = 579

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 67/198 (33%), Positives = 75/198 (37%), Gaps = 29/198 (14%)

Query: 501 PKPCLPEECGEPQPCPPAEPGPPEAFC--RSEPEIPEPSLQEQLEVPEPYPPAEPRPLES 558
           P+P     C  P+  P  EP P  +FC  R   + PE  LQ     P P P    RP E 
Sbjct: 359 PQPSWGASC--PELRPHVEPRPLPSFCPPRRLDQCPESPLQR---CPPPAPRPRLRP-EP 412

Query: 559 CCRSEPEIPESSRQ--EQLEVPEPCPPAEP--RPLESYCRIEPEIPESSRQEQ-LEVPEP 613
           C   EP      RQ  E    PEP P   P  RP+      + EIPE     Q  E PEP
Sbjct: 413 CISLEPRPRPLPRQLSEPCLYPEPLPALRPTPRPVPLPRPGQCEIPEPRPCLQPCEHPEP 472

Query: 614 CPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLI 673
           CP  EP PL          P PCP     + EPC    RS      P    + P      
Sbjct: 473 CPRPEPIPL----------PAPCP-----SPEPCRETWRSPSPCWGPNPVPY-PGDLGCH 516

Query: 674 FSSQHPLCASPPICSLQS 691
            SS H L    P C   S
Sbjct: 517 ESSPHRLDTEAPYCGPSS 534



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 52/136 (38%), Positives = 57/136 (41%), Gaps = 20/136 (14%)

Query: 500 LPKPCLP---EECGEP--QPCPPAEPGP---PEAFCRSEPEIPEP---SLQEQLEVPEPY 548
           LP  C P   ++C E   Q CPP  P P   PE     EP  P P    L E    PEP 
Sbjct: 379 LPSFCPPRRLDQCPESPLQRCPPPAPRPRLRPEPCISLEPR-PRPLPRQLSEPCLYPEPL 437

Query: 549 PPAEP--RPLESCCRSEPEIPESSRQEQ-LEVPEPCPPAEPRPLESYCRIEPEIPESSRQ 605
           P   P  RP+      + EIPE     Q  E PEPCP  EP PL + C      PE  R 
Sbjct: 438 PALRPTPRPVPLPRPGQCEIPEPRPCLQPCEHPEPCPRPEPIPLPAPC----PSPEPCR- 492

Query: 606 EQLEVPEPCPPAEPGP 621
           E    P PC    P P
Sbjct: 493 ETWRSPSPCWGPNPVP 508



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 57/176 (32%), Positives = 71/176 (40%), Gaps = 40/176 (22%)

Query: 488 TSHLPGLLKHSGLPKPCLPEECGEP---QPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEV 544
           +S+LP L    G P  C P    EP     CP      P + C S+   P+     ++E+
Sbjct: 280 SSYLP-LRPSEGFPNYCTPPRRSEPIYNSRCPRR----PISSC-SQRRGPKC----RIEI 329

Query: 545 PEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPC---------PPAEPRPLESYC-- 593
             P  P +  P     R   EIP   R+ Q   P+P          P  EPRPL S+C  
Sbjct: 330 SSPCCPRQVPPQ----RCPVEIPPIRRRSQSCGPQPSWGASCPELRPHVEPRPLPSFCPP 385

Query: 594 RIEPEIPESSRQEQLEVPEPCPPAEPGP-LQPSTQGQSGP-PGPCPRVELGASEPC 647
           R   + PES  Q        CPP  P P L+P       P P P PR     SEPC
Sbjct: 386 RRLDQCPESPLQR-------CPPPAPRPRLRPEPCISLEPRPRPLPR---QLSEPC 431


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 85/400 (21%), Positives = 121/400 (30%), Gaps = 48/400 (12%)

Query: 308 PAPVAQPLPGHVVP---CPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTP 364
           P P     P    P    P+    A   P    PT T  +        P T   P P+TP
Sbjct: 216 PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP 275

Query: 365 RVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRT 424
           +       +  +P +    P  P E                     P   TP+ P     
Sbjct: 276 KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP-KEPA 334

Query: 425 PSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLNATEH 484
           P+ +E              ++       +  P            +P  T        T  
Sbjct: 335 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK 394

Query: 485 NSGTSH---LPGLLKHSGL-PKPCLPEECGEPQPCPPAEPGP--PEAFCRSEPEIPEPSL 538
           ++ T+     P   K +   PK   P    EP P  P EP P  P+    + P+ P P+ 
Sbjct: 395 SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTT 454

Query: 539 QEQ-----LEVPEPYPPAEPRPL------------------ESCCRSEPEIPESSRQEQL 575
            ++      + P P  P EP P                   E    + PE P  +  E+L
Sbjct: 455 PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 514

Query: 576 -----EVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQS 630
                E P P  P EP P        P  P+       + P P  P EP P  P     +
Sbjct: 515 APTTPEEPTPTTPEEPAPTTPKAAA-PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 573

Query: 631 GPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATT 670
            P G         + P TL+  +  +   P   + AP TT
Sbjct: 574 TPKG---------TAPTTLKEPAPTTPKKPAPKELAPTTT 604



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 50/189 (26%), Positives = 71/189 (37%), Gaps = 40/189 (21%)

Query: 501 PKPCLPEECG-----EPQPCPPAEPGP--PEAFCRSEPEIPEPSLQEQLEVPEPYPPAEP 553
           P P  PEE       EP P  P EP P  P+A   + P+ P P+  ++   P P  P EP
Sbjct: 506 PAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE---PAPTTPKEP 562

Query: 554 RPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLE-----------SYC-RIEPEIPE 601
            P      + P  P+ +    L+ P P  P +P P E           + C +  P  P+
Sbjct: 563 APTTPK-ETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 621

Query: 602 SSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPC 661
            +     + P P  P EP P  P                   + P TL+  +  +   P 
Sbjct: 622 GTAPTTPKEPAPTTPKEPAPTTPK-----------------GTAPTTLKEPAPTTPKKPA 664

Query: 662 CSQWAPATT 670
             + AP TT
Sbjct: 665 PKELAPTTT 673



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 35/133 (26%), Positives = 48/133 (36%), Gaps = 18/133 (13%)

Query: 511 EPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESS 570
           EP P  P EP        + P+ P P+  +      P  P EP P  +  +S P  P+  
Sbjct: 215 EPTPTTPKEPAS------TTPKEPTPTTIKSA----PTTPKEPAPTTT--KSAPTTPKEP 262

Query: 571 RQEQLEVPEPCPPAEP------RPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQP 624
                + P P  P EP       P  +  +  P  P+       + P P  P EP P  P
Sbjct: 263 APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTP 322

Query: 625 STQGQSGPPGPCP 637
                + P  P P
Sbjct: 323 KEPTPTTPKEPAP 335



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 42/169 (24%), Positives = 56/169 (33%), Gaps = 38/169 (22%)

Query: 501 PKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCC 560
           PK   P    EP P  P EP          P  P+ +    L+ P P  P +P P E   
Sbjct: 620 PKGTAPTTPKEPAPTTPKEPA---------PTTPKGTAPTTLKEPAPTTPKKPAPKELA- 669

Query: 561 RSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPG 620
              P   +       + P P  P E  P                    + P P  P +P 
Sbjct: 670 ---PTTTKGPTSTTSDKPAPTTPKETAPTTP-----------------KEPAPTTPKKPA 709

Query: 621 PLQPSTQGQSGPPGPCPRVELGAS--EPCTLEHRSLESSLPPCCSQWAP 667
           P  P T     PP     V    +  EP T+ H+S + S P   ++  P
Sbjct: 710 PTTPET-----PPPTTSEVSTPTTTKEPTTI-HKSPDESTPELSAEPTP 752



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 89/422 (21%), Positives = 131/422 (31%), Gaps = 60/422 (14%)

Query: 10  PLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQRPLVDSAGPR 69
           P  +  +PT  K P  +  + P PT          ++P     K P     P      P 
Sbjct: 335 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP----SPTTPKE-PA 389

Query: 70  PKARHQAETSQRLVGISQPRN-PLEELRPSPRGQNVGPGPPAQTE-APGTIEFVADPAAL 127
           P     A T+ +    +  ++ P     PSP      P P    E AP T      P   
Sbjct: 390 PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPT-TTKEPAPTTPKEPAPTT------PKKP 442

Query: 128 ATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTHRLDPARA 187
           A     E   +      P+  K+         TT +          AP TP  +L P   
Sbjct: 443 APTTPKEPAPTTPKEPAPTTTKK------PAPTTPKEPAPTTPKETAPTTP-KKLTPTTP 495

Query: 188 SCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRTSVSQASG 247
              +      P   T  P+ L    +P+ P     T P         A +  T    A  
Sbjct: 496 EKLAPTTPEKPAPTT--PEEL----APTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP- 548

Query: 248 LLLETPVQPAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSHDSHLMPS 307
               TP +PA + PK E    T  +       G A    L+E                P+
Sbjct: 549 ---TTPKEPAPTTPK-EPAPTTPKETAPTTPKGTAP-TTLKE----------------PA 587

Query: 308 PAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTPRVQ 367
           P    +P P  + P  +    +     P P T             P T   P P+TP+  
Sbjct: 588 PTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG--------TAPTTPKEPAPTTPKEP 639

Query: 368 QAQWLRGVSPQSCSED-PALPWEQVAVRLFDQESCIRSLEGSGKPPVATP--SGPHSNRT 424
                +G +P +  E  P  P +     L    +   +   S KP   TP  + P + + 
Sbjct: 640 APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE 699

Query: 425 PS 426
           P+
Sbjct: 700 PA 701


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 85/400 (21%), Positives = 121/400 (30%), Gaps = 48/400 (12%)

Query: 308 PAPVAQPLPGHVVP---CPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTP 364
           P P     P    P    P+    A   P    PT T  +        P T   P P+TP
Sbjct: 257 PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP 316

Query: 365 RVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRT 424
           +       +  +P +    P  P E                     P   TP+ P     
Sbjct: 317 KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP-KEPA 375

Query: 425 PSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLNATEH 484
           P+ +E              ++       +  P            +P  T        T  
Sbjct: 376 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK 435

Query: 485 NSGTSH---LPGLLKHSGL-PKPCLPEECGEPQPCPPAEPGP--PEAFCRSEPEIPEPSL 538
           ++ T+     P   K +   PK   P    EP P  P EP P  P+    + P+ P P+ 
Sbjct: 436 SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTT 495

Query: 539 QEQ-----LEVPEPYPPAEPRPL------------------ESCCRSEPEIPESSRQEQL 575
            ++      + P P  P EP P                   E    + PE P  +  E+L
Sbjct: 496 PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 555

Query: 576 -----EVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQS 630
                E P P  P EP P        P  P+       + P P  P EP P  P     +
Sbjct: 556 APTTPEEPTPTTPEEPAPTTPKAAA-PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 614

Query: 631 GPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATT 670
            P G         + P TL+  +  +   P   + AP TT
Sbjct: 615 TPKG---------TAPTTLKEPAPTTPKKPAPKELAPTTT 645



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 50/189 (26%), Positives = 71/189 (37%), Gaps = 40/189 (21%)

Query: 501 PKPCLPEECG-----EPQPCPPAEPGP--PEAFCRSEPEIPEPSLQEQLEVPEPYPPAEP 553
           P P  PEE       EP P  P EP P  P+A   + P+ P P+  ++   P P  P EP
Sbjct: 547 PAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE---PAPTTPKEP 603

Query: 554 RPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLE-----------SYC-RIEPEIPE 601
            P      + P  P+ +    L+ P P  P +P P E           + C +  P  P+
Sbjct: 604 APTTPK-ETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 662

Query: 602 SSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPC 661
            +     + P P  P EP P  P                   + P TL+  +  +   P 
Sbjct: 663 GTAPTTPKEPAPTTPKEPAPTTPK-----------------GTAPTTLKEPAPTTPKKPA 705

Query: 662 CSQWAPATT 670
             + AP TT
Sbjct: 706 PKELAPTTT 714



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 35/133 (26%), Positives = 48/133 (36%), Gaps = 18/133 (13%)

Query: 511 EPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESS 570
           EP P  P EP        + P+ P P+  +      P  P EP P  +  +S P  P+  
Sbjct: 256 EPTPTTPKEPAS------TTPKEPTPTTIKSA----PTTPKEPAPTTT--KSAPTTPKEP 303

Query: 571 RQEQLEVPEPCPPAEP------RPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQP 624
                + P P  P EP       P  +  +  P  P+       + P P  P EP P  P
Sbjct: 304 APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTP 363

Query: 625 STQGQSGPPGPCP 637
                + P  P P
Sbjct: 364 KEPTPTTPKEPAP 376



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 42/169 (24%), Positives = 56/169 (33%), Gaps = 38/169 (22%)

Query: 501 PKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCC 560
           PK   P    EP P  P EP          P  P+ +    L+ P P  P +P P E   
Sbjct: 661 PKGTAPTTPKEPAPTTPKEPA---------PTTPKGTAPTTLKEPAPTTPKKPAPKELA- 710

Query: 561 RSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPG 620
              P   +       + P P  P E  P                    + P P  P +P 
Sbjct: 711 ---PTTTKGPTSTTSDKPAPTTPKETAPTTP-----------------KEPAPTTPKKPA 750

Query: 621 PLQPSTQGQSGPPGPCPRVELGAS--EPCTLEHRSLESSLPPCCSQWAP 667
           P  P T     PP     V    +  EP T+ H+S + S P   ++  P
Sbjct: 751 PTTPET-----PPPTTSEVSTPTTTKEPTTI-HKSPDESTPELSAEPTP 793



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 89/422 (21%), Positives = 131/422 (31%), Gaps = 60/422 (14%)

Query: 10  PLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQRPLVDSAGPR 69
           P  +  +PT  K P  +  + P PT          ++P     K P     P      P 
Sbjct: 376 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP----SPTTPKE-PA 430

Query: 70  PKARHQAETSQRLVGISQPRN-PLEELRPSPRGQNVGPGPPAQTE-APGTIEFVADPAAL 127
           P     A T+ +    +  ++ P     PSP      P P    E AP T      P   
Sbjct: 431 PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPT-TTKEPAPTTPKEPAPTT------PKKP 483

Query: 128 ATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTHRLDPARA 187
           A     E   +      P+  K+         TT +          AP TP  +L P   
Sbjct: 484 APTTPKEPAPTTPKEPAPTTTKK------PAPTTPKEPAPTTPKETAPTTP-KKLTPTTP 536

Query: 188 SCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRTSVSQASG 247
              +      P   T  P+ L    +P+ P     T P         A +  T    A  
Sbjct: 537 EKLAPTTPEKPAPTT--PEEL----APTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP- 589

Query: 248 LLLETPVQPAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSHDSHLMPS 307
               TP +PA + PK E    T  +       G A    L+E                P+
Sbjct: 590 ---TTPKEPAPTTPK-EPAPTTPKETAPTTPKGTAP-TTLKE----------------PA 628

Query: 308 PAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTPRVQ 367
           P    +P P  + P  +    +     P P T             P T   P P+TP+  
Sbjct: 629 PTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG--------TAPTTPKEPAPTTPKEP 680

Query: 368 QAQWLRGVSPQSCSED-PALPWEQVAVRLFDQESCIRSLEGSGKPPVATP--SGPHSNRT 424
                +G +P +  E  P  P +     L    +   +   S KP   TP  + P + + 
Sbjct: 681 APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE 740

Query: 425 PS 426
           P+
Sbjct: 741 PA 742


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 85/400 (21%), Positives = 121/400 (30%), Gaps = 48/400 (12%)

Query: 308 PAPVAQPLPGHVVP---CPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTP 364
           P P     P    P    P+    A   P    PT T  +        P T   P P+TP
Sbjct: 309 PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP 368

Query: 365 RVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRT 424
           +       +  +P +    P  P E                     P   TP+ P     
Sbjct: 369 KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP-KEPA 427

Query: 425 PSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLNATEH 484
           P+ +E              ++       +  P            +P  T        T  
Sbjct: 428 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK 487

Query: 485 NSGTSH---LPGLLKHSGL-PKPCLPEECGEPQPCPPAEPGP--PEAFCRSEPEIPEPSL 538
           ++ T+     P   K +   PK   P    EP P  P EP P  P+    + P+ P P+ 
Sbjct: 488 SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTT 547

Query: 539 QEQ-----LEVPEPYPPAEPRPL------------------ESCCRSEPEIPESSRQEQL 575
            ++      + P P  P EP P                   E    + PE P  +  E+L
Sbjct: 548 PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 607

Query: 576 -----EVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQS 630
                E P P  P EP P        P  P+       + P P  P EP P  P     +
Sbjct: 608 APTTPEEPTPTTPEEPAPTTPKAAA-PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 666

Query: 631 GPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATT 670
            P G         + P TL+  +  +   P   + AP TT
Sbjct: 667 TPKG---------TAPTTLKEPAPTTPKKPAPKELAPTTT 697



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 50/189 (26%), Positives = 71/189 (37%), Gaps = 40/189 (21%)

Query: 501 PKPCLPEECG-----EPQPCPPAEPGP--PEAFCRSEPEIPEPSLQEQLEVPEPYPPAEP 553
           P P  PEE       EP P  P EP P  P+A   + P+ P P+  ++   P P  P EP
Sbjct: 599 PAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE---PAPTTPKEP 655

Query: 554 RPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLE-----------SYC-RIEPEIPE 601
            P      + P  P+ +    L+ P P  P +P P E           + C +  P  P+
Sbjct: 656 APTTPK-ETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 714

Query: 602 SSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPC 661
            +     + P P  P EP P  P                   + P TL+  +  +   P 
Sbjct: 715 GTAPTTPKEPAPTTPKEPAPTTPK-----------------GTAPTTLKEPAPTTPKKPA 757

Query: 662 CSQWAPATT 670
             + AP TT
Sbjct: 758 PKELAPTTT 766



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 35/133 (26%), Positives = 48/133 (36%), Gaps = 18/133 (13%)

Query: 511 EPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESS 570
           EP P  P EP        + P+ P P+  +      P  P EP P  +  +S P  P+  
Sbjct: 308 EPTPTTPKEPAS------TTPKEPTPTTIKSA----PTTPKEPAPTTT--KSAPTTPKEP 355

Query: 571 RQEQLEVPEPCPPAEP------RPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQP 624
                + P P  P EP       P  +  +  P  P+       + P P  P EP P  P
Sbjct: 356 APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTP 415

Query: 625 STQGQSGPPGPCP 637
                + P  P P
Sbjct: 416 KEPTPTTPKEPAP 428



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 42/169 (24%), Positives = 56/169 (33%), Gaps = 38/169 (22%)

Query: 501 PKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCC 560
           PK   P    EP P  P EP          P  P+ +    L+ P P  P +P P E   
Sbjct: 713 PKGTAPTTPKEPAPTTPKEPA---------PTTPKGTAPTTLKEPAPTTPKKPAPKELA- 762

Query: 561 RSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPG 620
              P   +       + P P  P E  P                    + P P  P +P 
Sbjct: 763 ---PTTTKGPTSTTSDKPAPTTPKETAPTTP-----------------KEPAPTTPKKPA 802

Query: 621 PLQPSTQGQSGPPGPCPRVELGAS--EPCTLEHRSLESSLPPCCSQWAP 667
           P  P T     PP     V    +  EP T+ H+S + S P   ++  P
Sbjct: 803 PTTPET-----PPPTTSEVSTPTTTKEPTTI-HKSPDESTPELSAEPTP 845



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 89/422 (21%), Positives = 131/422 (31%), Gaps = 60/422 (14%)

Query: 10  PLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQRPLVDSAGPR 69
           P  +  +PT  K P  +  + P PT          ++P     K P     P      P 
Sbjct: 428 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP----SPTTPKE-PA 482

Query: 70  PKARHQAETSQRLVGISQPRN-PLEELRPSPRGQNVGPGPPAQTE-APGTIEFVADPAAL 127
           P     A T+ +    +  ++ P     PSP      P P    E AP T      P   
Sbjct: 483 PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPT-TTKEPAPTTPKEPAPTT------PKKP 535

Query: 128 ATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTHRLDPARA 187
           A     E   +      P+  K+         TT +          AP TP  +L P   
Sbjct: 536 APTTPKEPAPTTPKEPAPTTTKK------PAPTTPKEPAPTTPKETAPTTP-KKLTPTTP 588

Query: 188 SCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRTSVSQASG 247
              +      P   T  P+ L    +P+ P     T P         A +  T    A  
Sbjct: 589 EKLAPTTPEKPAPTT--PEEL----APTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP- 641

Query: 248 LLLETPVQPAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSHDSHLMPS 307
               TP +PA + PK E    T  +       G A    L+E                P+
Sbjct: 642 ---TTPKEPAPTTPK-EPAPTTPKETAPTTPKGTAP-TTLKE----------------PA 680

Query: 308 PAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTPRVQ 367
           P    +P P  + P  +    +     P P T             P T   P P+TP+  
Sbjct: 681 PTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG--------TAPTTPKEPAPTTPKEP 732

Query: 368 QAQWLRGVSPQSCSED-PALPWEQVAVRLFDQESCIRSLEGSGKPPVATP--SGPHSNRT 424
                +G +P +  E  P  P +     L    +   +   S KP   TP  + P + + 
Sbjct: 733 APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE 792

Query: 425 PS 426
           P+
Sbjct: 793 PA 794


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 85/400 (21%), Positives = 121/400 (30%), Gaps = 48/400 (12%)

Query: 308 PAPVAQPLPGHVVP---CPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTP 364
           P P     P    P    P+    A   P    PT T  +        P T   P P+TP
Sbjct: 350 PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP 409

Query: 365 RVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRT 424
           +       +  +P +    P  P E                     P   TP+ P     
Sbjct: 410 KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP-KEPA 468

Query: 425 PSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLNATEH 484
           P+ +E              ++       +  P            +P  T        T  
Sbjct: 469 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK 528

Query: 485 NSGTSH---LPGLLKHSGL-PKPCLPEECGEPQPCPPAEPGP--PEAFCRSEPEIPEPSL 538
           ++ T+     P   K +   PK   P    EP P  P EP P  P+    + P+ P P+ 
Sbjct: 529 SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTT 588

Query: 539 QEQ-----LEVPEPYPPAEPRPL------------------ESCCRSEPEIPESSRQEQL 575
            ++      + P P  P EP P                   E    + PE P  +  E+L
Sbjct: 589 PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 648

Query: 576 -----EVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQS 630
                E P P  P EP P        P  P+       + P P  P EP P  P     +
Sbjct: 649 APTTPEEPTPTTPEEPAPTTPKAAA-PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 707

Query: 631 GPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATT 670
            P G         + P TL+  +  +   P   + AP TT
Sbjct: 708 TPKG---------TAPTTLKEPAPTTPKKPAPKELAPTTT 738



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 50/189 (26%), Positives = 71/189 (37%), Gaps = 40/189 (21%)

Query: 501 PKPCLPEECG-----EPQPCPPAEPGP--PEAFCRSEPEIPEPSLQEQLEVPEPYPPAEP 553
           P P  PEE       EP P  P EP P  P+A   + P+ P P+  ++   P P  P EP
Sbjct: 640 PAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE---PAPTTPKEP 696

Query: 554 RPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLE-----------SYC-RIEPEIPE 601
            P      + P  P+ +    L+ P P  P +P P E           + C +  P  P+
Sbjct: 697 APTTPK-ETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 755

Query: 602 SSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPC 661
            +     + P P  P EP P  P                   + P TL+  +  +   P 
Sbjct: 756 GTAPTTPKEPAPTTPKEPAPTTPK-----------------GTAPTTLKEPAPTTPKKPA 798

Query: 662 CSQWAPATT 670
             + AP TT
Sbjct: 799 PKELAPTTT 807



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 35/133 (26%), Positives = 48/133 (36%), Gaps = 18/133 (13%)

Query: 511 EPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESS 570
           EP P  P EP        + P+ P P+  +      P  P EP P  +  +S P  P+  
Sbjct: 349 EPTPTTPKEPAS------TTPKEPTPTTIKSA----PTTPKEPAPTTT--KSAPTTPKEP 396

Query: 571 RQEQLEVPEPCPPAEP------RPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQP 624
                + P P  P EP       P  +  +  P  P+       + P P  P EP P  P
Sbjct: 397 APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTP 456

Query: 625 STQGQSGPPGPCP 637
                + P  P P
Sbjct: 457 KEPTPTTPKEPAP 469



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 42/169 (24%), Positives = 56/169 (33%), Gaps = 38/169 (22%)

Query: 501 PKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCC 560
           PK   P    EP P  P EP          P  P+ +    L+ P P  P +P P E   
Sbjct: 754 PKGTAPTTPKEPAPTTPKEPA---------PTTPKGTAPTTLKEPAPTTPKKPAPKELA- 803

Query: 561 RSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPG 620
              P   +       + P P  P E  P                    + P P  P +P 
Sbjct: 804 ---PTTTKGPTSTTSDKPAPTTPKETAPTTP-----------------KEPAPTTPKKPA 843

Query: 621 PLQPSTQGQSGPPGPCPRVELGAS--EPCTLEHRSLESSLPPCCSQWAP 667
           P  P T     PP     V    +  EP T+ H+S + S P   ++  P
Sbjct: 844 PTTPET-----PPPTTSEVSTPTTTKEPTTI-HKSPDESTPELSAEPTP 886



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 89/422 (21%), Positives = 131/422 (31%), Gaps = 60/422 (14%)

Query: 10  PLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQRPLVDSAGPR 69
           P  +  +PT  K P  +  + P PT          ++P     K P     P      P 
Sbjct: 469 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP----SPTTPKE-PA 523

Query: 70  PKARHQAETSQRLVGISQPRN-PLEELRPSPRGQNVGPGPPAQTE-APGTIEFVADPAAL 127
           P     A T+ +    +  ++ P     PSP      P P    E AP T      P   
Sbjct: 524 PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPT-TTKEPAPTTPKEPAPTT------PKKP 576

Query: 128 ATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTHRLDPARA 187
           A     E   +      P+  K+         TT +          AP TP  +L P   
Sbjct: 577 APTTPKEPAPTTPKEPAPTTTKK------PAPTTPKEPAPTTPKETAPTTP-KKLTPTTP 629

Query: 188 SCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRTSVSQASG 247
              +      P   T  P+ L    +P+ P     T P         A +  T    A  
Sbjct: 630 EKLAPTTPEKPAPTT--PEEL----APTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP- 682

Query: 248 LLLETPVQPAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSHDSHLMPS 307
               TP +PA + PK E    T  +       G A    L+E                P+
Sbjct: 683 ---TTPKEPAPTTPK-EPAPTTPKETAPTTPKGTAP-TTLKE----------------PA 721

Query: 308 PAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTPRVQ 367
           P    +P P  + P  +    +     P P T             P T   P P+TP+  
Sbjct: 722 PTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKG--------TAPTTPKEPAPTTPKEP 773

Query: 368 QAQWLRGVSPQSCSED-PALPWEQVAVRLFDQESCIRSLEGSGKPPVATP--SGPHSNRT 424
                +G +P +  E  P  P +     L    +   +   S KP   TP  + P + + 
Sbjct: 774 APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE 833

Query: 425 PS 426
           P+
Sbjct: 834 PA 835


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
           sapiens]
          Length = 2715

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 83/339 (24%), Positives = 121/339 (35%), Gaps = 42/339 (12%)

Query: 292 EMSHTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTV 351
           EM    +  ++ L P P     P P   +P PS        P P PP            V
Sbjct: 389 EMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPP------------V 436

Query: 352 QPKTRFTPMPSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKP 411
            P    +P P   + +Q +    V P +CS     P    + R  ++E+     EG+  P
Sbjct: 437 SPPPLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRA-EREAARAGPEGT-SP 494

Query: 412 PVATPSGPHSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQC--VPLNGGSSLDMVELQ 469
           P  TPS            V  +    L+  +RQ +  +V  +   V       +D    +
Sbjct: 495 PTPTPSTATGGPPEDSPTVAPKSTTFLKN-IRQFIMPVVSARSSRVIKTPRRFMDEDPPK 553

Query: 470 PLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRS 529
           P   E+S  L            P +     +P+   P       P PP+ P P     RS
Sbjct: 554 PPKVEVSPVLR-----------PPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRS 602

Query: 530 ---EPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEP 586
              EP     SL  +L  P P PP  P P      S P  P +S +  L +  P    + 
Sbjct: 603 ILREPTFRWTSLTRELPPPPPAPPPPPAP------SPPPAPATSSRRPLLLRAP----QF 652

Query: 587 RPLESYCRIEPEIPESSRQEQLEVPEP-CPPAEPGPLQP 624
            P E++ +I   +         E PEP  PPA+  P +P
Sbjct: 653 TPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEP 691



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 40/139 (28%), Positives = 46/139 (33%), Gaps = 28/139 (20%)

Query: 501 PKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCC 560
           P P  P     P P PP    PP   C                 P P PP  P PL S  
Sbjct: 403 PPPLTPPAPSPPPPLPPPSTSPPPPLC-----------------PPPPPPVSPPPLPS-- 443

Query: 561 RSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPG 620
                 P  +++EQ E P P  PA      S  R  P +  S R E+ E     P     
Sbjct: 444 ----PPPPPAQEEQEESPPPVVPATC----SRKRGRPPLTPSQRAER-EAARAGPEGTSP 494

Query: 621 PLQPSTQGQSGPPGPCPRV 639
           P    +    GPP   P V
Sbjct: 495 PTPTPSTATGGPPEDSPTV 513



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 41/153 (26%), Positives = 49/153 (32%), Gaps = 29/153 (18%)

Query: 506 PEECGEPQPCPP-AEPGPPE-----------------------AFCRSEPEIPEPSLQEQ 541
           PE    P P P  A  GPPE                          RS   I  P     
Sbjct: 489 PEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMD 548

Query: 542 LEVPEPYPPAEPRP-LESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRI---EP 597
            + P+P P  E  P L     + P +P+           P PP+ P PL    R    EP
Sbjct: 549 EDPPKP-PKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREP 607

Query: 598 EIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQS 630
               +S   +L  P P PP  P P  P     S
Sbjct: 608 TFRWTSLTRELPPPPPAPPPPPAPSPPPAPATS 640



 Score = 34.7 bits (78), Expect = 0.35
 Identities = 40/161 (24%), Positives = 56/161 (34%), Gaps = 28/161 (17%)

Query: 559 CCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAE 618
           C + + +  +   +E+ E  E     E +  E     E  +P + ++E    P P  P  
Sbjct: 353 CWKKQEQKLDDEEEEKKEEEEKDKEGEEK--EERAVAEEMMPAAEKEEAKLPPPPLTPPA 410

Query: 619 PGPLQPSTQGQSGPPGP-CPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQ 677
           P P  P     + PP P CP      S P       L S  PP      PA        +
Sbjct: 411 PSPPPPLPPPSTSPPPPLCPPPPPPVSPP------PLPSPPPP------PAQEE---QEE 455

Query: 678 HPLCASPPICSLQSLRPP----------AGQAGLSNLAPRT 708
            P    P  CS +  RPP          A +AG    +P T
Sbjct: 456 SPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPT 496



 Score = 34.3 bits (77), Expect = 0.45
 Identities = 38/135 (28%), Positives = 44/135 (32%), Gaps = 25/135 (18%)

Query: 516  PPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPR------PLESCCRSEPEIPES 569
            PP  P    A     P  P      +++VP   P   P       PL S     P  P S
Sbjct: 1843 PPLRPDSGSA----PPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPS-----PGSPSS 1893

Query: 570  SRQEQLEVPEPCPPAEPRPLESYCRIEPEIPES-------SRQEQLEVPEPCPPAEPGPL 622
                   V +P  PA PR       + P  P S           QL VP   PP      
Sbjct: 1894 LTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVP---PPTSVVTA 1950

Query: 623  QPSTQGQSGPPGPCP 637
               T G+  PPGP P
Sbjct: 1951 LTPTSGELAPPGPAP 1965



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 33/117 (28%), Positives = 43/117 (36%), Gaps = 13/117 (11%)

Query: 533 IPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQL-EVPEP--CPPAEPRPL 589
           +P P L +    P P  PA  R  E   R    + E  R+ Q  + P    C P+ PR  
Sbjct: 161 LPPPRLADVAPTP-PKTPARKRGEEGTERMVQALTELLRRAQAPQAPRSRACEPSTPRRS 219

Query: 590 ESYCRIEPEIPESSRQEQLEV---------PEPCPPAEPGPLQPSTQGQSGPPGPCP 637
                  P  P   +Q+ + V         PEP PP  P   Q  +      PGP P
Sbjct: 220 RGRPPGRPAGPCRRKQQAVVVAEAAVTIPKPEPPPPVVPVKHQTGSWKCKEGPGPGP 276



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 42/160 (26%), Positives = 56/160 (35%), Gaps = 36/160 (22%)

Query: 510  GEPQPCPPAEPGPPEAFCRSEPEI----PEPSLQ--EQLEVPEPYPPAEPRPLESCCRSE 563
            GEP P P  +P  P     + P      P P L     + V  P PP  P PL     S 
Sbjct: 2208 GEPVPPPVKQPPLPPTISPTAPTSWTLPPGPLLGVLPVVGVVRPAPPPPPPPLTLVLSSG 2267

Query: 564  PEIP--ESSRQEQLEV------PEPCPPAEPRPLE-----------------SYCRIEPE 598
            P  P  ++ R +++        P P P   PR  E                  + R+  +
Sbjct: 2268 PASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEASEDTPQVPGLGSGGFSRVRMK 2327

Query: 599  IPESSRQEQLEVP-EPCPPAEPGPLQPSTQ----GQSGPP 633
             P       L+ P EP     PGPLQ  +      + GPP
Sbjct: 2328 TPTVRGVLDLDRPGEPAGEESPGPLQERSPLLPLPEDGPP 2367


>gi|119943102 CREB binding protein isoform b [Homo sapiens]
          Length = 2404

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 59/225 (26%), Positives = 93/225 (41%), Gaps = 35/225 (15%)

Query: 500  LPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPA-EPRPLES 558
            +P+  LP     P   P  +P        S P+ P+P  Q     P+P P +  P    S
Sbjct: 1839 VPQQSLPSPTSAPPGTPTQQP--------STPQTPQPPAQ-----PQPSPVSMSPAGFPS 1885

Query: 559  CCRSEPEIPESSRQEQLEVPEPCPPAEPRP--LESYCRIEPEIPESSRQEQLEVPEPCPP 616
              R++P    S+ +   +VP P PPA+P P  +E+  +IE E  +     ++ +    PP
Sbjct: 1886 VARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPP 1945

Query: 617  AEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSS 676
               G   P +Q           V L    P  +    +  S+PP   QW  A        
Sbjct: 1946 GRTGMGTPGSQ--------MAPVSLNVPRPNQVS-GPVMPSMPP--GQWQQAP----LPQ 1990

Query: 677  QHPLCASP-PICSLQSLRPPAGQAGLSNLAPRTL---ALRERLKS 717
            Q P+   P P+ S+Q+    AG    S   PR++   AL++ L++
Sbjct: 1991 QQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRT 2035



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 58/245 (23%), Positives = 91/245 (37%), Gaps = 36/245 (14%)

Query: 462 SLDMVELQ--PLLTEISRTLNATEHNSGTSHLPGL-LKHSGLPKPCLPEECGEPQPCPPA 518
           SL  V+L   P+    +  +N +   +    +PG+ +  S +P+P  P   G       A
Sbjct: 690 SLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQP--PNMMGAHTNNMMA 747

Query: 519 EPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEV- 577
           +      F    P+   PS    + V    PPA+         S+ ++P ++    L + 
Sbjct: 748 QAPAQSQFL---PQNQFPSSSGAMSVGMGQPPAQTGV------SQGQVPGAALPNPLNML 798

Query: 578 -PE----PCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEP---CPPAEPGPLQPST--- 626
            P+    PCPP    PL       P    ++    L+   P    PP    P QPST   
Sbjct: 799 GPQASQLPCPPVTQSPLHP---TPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVS 855

Query: 627 ---QGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQH---PL 680
              Q  +  PG  P      S P T++  +     P   +   P + +   SSQ    P+
Sbjct: 856 SSGQTPTPTPGSVPSATQTQSTP-TVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPV 914

Query: 681 CASPP 685
            A PP
Sbjct: 915 HAQPP 919


>gi|119943104 CREB binding protein isoform a [Homo sapiens]
          Length = 2442

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 59/225 (26%), Positives = 93/225 (41%), Gaps = 35/225 (15%)

Query: 500  LPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPA-EPRPLES 558
            +P+  LP     P   P  +P        S P+ P+P  Q     P+P P +  P    S
Sbjct: 1877 VPQQSLPSPTSAPPGTPTQQP--------STPQTPQPPAQ-----PQPSPVSMSPAGFPS 1923

Query: 559  CCRSEPEIPESSRQEQLEVPEPCPPAEPRP--LESYCRIEPEIPESSRQEQLEVPEPCPP 616
              R++P    S+ +   +VP P PPA+P P  +E+  +IE E  +     ++ +    PP
Sbjct: 1924 VARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPP 1983

Query: 617  AEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSS 676
               G   P +Q           V L    P  +    +  S+PP   QW  A        
Sbjct: 1984 GRTGMGTPGSQ--------MAPVSLNVPRPNQVS-GPVMPSMPP--GQWQQAP----LPQ 2028

Query: 677  QHPLCASP-PICSLQSLRPPAGQAGLSNLAPRTL---ALRERLKS 717
            Q P+   P P+ S+Q+    AG    S   PR++   AL++ L++
Sbjct: 2029 QQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRT 2073



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 58/245 (23%), Positives = 91/245 (37%), Gaps = 36/245 (14%)

Query: 462 SLDMVELQ--PLLTEISRTLNATEHNSGTSHLPGL-LKHSGLPKPCLPEECGEPQPCPPA 518
           SL  V+L   P+    +  +N +   +    +PG+ +  S +P+P  P   G       A
Sbjct: 728 SLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQP--PNMMGAHTNNMMA 785

Query: 519 EPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEV- 577
           +      F    P+   PS    + V    PPA+         S+ ++P ++    L + 
Sbjct: 786 QAPAQSQFL---PQNQFPSSSGAMSVGMGQPPAQTGV------SQGQVPGAALPNPLNML 836

Query: 578 -PE----PCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEP---CPPAEPGPLQPST--- 626
            P+    PCPP    PL       P    ++    L+   P    PP    P QPST   
Sbjct: 837 GPQASQLPCPPVTQSPLHP---TPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVS 893

Query: 627 ---QGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQH---PL 680
              Q  +  PG  P      S P T++  +     P   +   P + +   SSQ    P+
Sbjct: 894 SSGQTPTPTPGSVPSATQTQSTP-TVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPV 952

Query: 681 CASPP 685
            A PP
Sbjct: 953 HAQPP 957


>gi|41281612 zinc finger protein 828 [Homo sapiens]
          Length = 812

 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 60/242 (24%), Positives = 85/242 (35%), Gaps = 43/242 (17%)

Query: 489 SHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPE-- 546
           SH P  L       P  P     P+P  P+    PE+   +    PEP      E PE  
Sbjct: 231 SHFPETLGPPSASSPESPVLAASPEPWGPSPAASPESRKSARTTSPEPRKPSPSESPEPW 290

Query: 547 -PYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQ 605
            P+P   P P     R  P +   S        +P PP  PRP +S          S+  
Sbjct: 291 KPFPAVSPEPR----RPAPAVSPGSW-------KPGPPGSPRPWKS--------NPSASS 331

Query: 606 EQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLES--------- 656
              +  +P P   PGP +P      GP  P P V   + +  ++   S +S         
Sbjct: 332 GPWKPAKPAPSVSPGPWKPIPSVSPGPWKPTPSVSSASWKSSSVSPSSWKSPPASPESWK 391

Query: 657 SLPPCCSQWAPATTSLIFSSQHPLC-----ASPPI-------CSLQSLRPPAGQAGLSNL 704
           S PP   + AP  +   + +  P+        PP+            LR P+G   L  L
Sbjct: 392 SGPPELRKTAPTLSPEHWKAVPPVSPELRKPGPPLSPEIRSPAGSPELRKPSGSPDLWKL 451

Query: 705 AP 706
           +P
Sbjct: 452 SP 453



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 48/177 (27%), Positives = 64/177 (36%), Gaps = 22/177 (12%)

Query: 464 DMVELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPP 523
           D V+  PL        N+ E  S    +P L   +      L  E  +P P  P EP  P
Sbjct: 104 DPVKSPPLPEHQKIPCNSAEPKS----IPALSMETQKLGSVLSPESPKPTPLTPLEPQKP 159

Query: 524 EAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEP--EIPESSRQEQLEVPEPC 581
            +    E           L+ P P P  EP    S    EP   +P    Q+   VP P 
Sbjct: 160 GSVVSPE-----------LQTPLPSP--EPSKPASVSSPEPPKSVPVCESQKLAPVPSP- 205

Query: 582 PPAEPRPLESYCRIEPEIPESSRQEQLEVPEPC-PPAEPGPLQPSTQGQSGPPGPCP 637
            P +P P+ S   ++  +     Q+Q   PE   PP+   P  P       P GP P
Sbjct: 206 EPQKPAPV-SPESVKATLSNPKPQKQSHFPETLGPPSASSPESPVLAASPEPWGPSP 261



 Score = 36.6 bits (83), Expect = 0.092
 Identities = 41/167 (24%), Positives = 59/167 (35%), Gaps = 24/167 (14%)

Query: 488 TSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEP 547
           TS  P     S  P+P  P     P+P  PA    P ++    P  P P          P
Sbjct: 274 TSPEPRKPSPSESPEPWKPFPAVSPEPRRPAPAVSPGSWKPGPPGSPRPWKSNPSASSGP 333

Query: 548 YPPAEPRPLES-------------CCRSEPEIPESSRQEQLEVPE--PCPPAEPRPLESY 592
           + PA+P P  S               +  P +  +S +     P     PPA P   ES+
Sbjct: 334 WKPAKPAPSVSPGPWKPIPSVSPGPWKPTPSVSSASWKSSSVSPSSWKSPPASP---ESW 390

Query: 593 CRIEPEIPESSRQEQLEVPEPCPPAEP------GPLQPSTQGQSGPP 633
               PE+ +++     E  +  PP  P       PL P  +  +G P
Sbjct: 391 KSGPPELRKTAPTLSPEHWKAVPPVSPELRKPGPPLSPEIRSPAGSP 437


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 173/776 (22%), Positives = 242/776 (31%), Gaps = 162/776 (20%)

Query: 63  VDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQTEAPGTIEFVA 122
           +  + PR      A TS R        NP      S RG+     PPA+  +PG +   +
Sbjct: 70  IPESAPRAGPTRSAGTSSR--------NPASRPPASGRGERA---PPAKNTSPGPVS--S 116

Query: 123 DPAALATILSGE-GVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTHR 181
              A  T   G  G K   +  + ++A+       +          R ++   P TP+  
Sbjct: 117 PGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALS-AGARRDTSGPTPGTPSPA 175

Query: 182 LDPARASCFSR--LEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAG--- 236
           +     +  +   L  P P  R   P       S S  S H +T PS    RR +AG   
Sbjct: 176 MARRSRAAGTEVGLPRPAPSARPRPPTEGPRK-SVSSASEHSTTEPSPAARRRPSAGGGL 234

Query: 237 ---SSRTSVSQASGLLL------------ETPVQPAFSLPKGEREV----VTHSDEGGVA 277
              +SR+  S A+ L                P  P+   PKG + +    VT   +    
Sbjct: 235 QRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAP 294

Query: 278 SLG---------------LAQRVPLRENREMSHTRDSHDSHLMPSPAPVAQPLPG----- 317
           +LG                A+ VP  +N           S  + +P P+A P P      
Sbjct: 295 ALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSL 354

Query: 318 HVVPCPSPFGRAQRVPS---------PGPPTLTSYSVLRRLTVQPKTRFTPMP------- 361
             +P P     +Q  PS         P   T+    V   LT  P  +  P P       
Sbjct: 355 QTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLT-SPSLQAPPSPLALSSLQ 413

Query: 362 -----STPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATP 416
                 +P +Q       +SP+        P  + A    D       L     PP+ T 
Sbjct: 414 ATTSLGSPTLQATHSFLTMSPRQTQASLTSP-SRPASTPPDSPPLQAPLSLPASPPLQTS 472

Query: 417 SGPHSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVP-LNGGSSLDMVELQ------ 469
             P  +  P    + I  +  L  L     +  +    +P L   SSL    LQ      
Sbjct: 473 LSPAVS--PLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASL 530

Query: 470 -------------PLLTEISRTLNATEHNSGTSHLPGLLKHSG----LPKPCLPEECGEP 512
                        P L   S  L      +     P  L+        P P  P     P
Sbjct: 531 TTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATP 590

Query: 513 QP-CPPAEPGPPEAFCRSEP----EIPEPSLQEQLEVPE----PYPPAEPRPLESCCRSE 563
            P  PPA   PP     S P      P P     L +P     P PPA P PL       
Sbjct: 591 PPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASP-PLSPLATPS 649

Query: 564 PEIPESSRQEQLEVPEPCPPAEP----------RPLESYCRIEPEIPESSRQEQLEVPEP 613
           P+ P +     L+ P   PP+ P           P+        + P S     L+VP P
Sbjct: 650 PQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVP-P 708

Query: 614 CPPAEPG-----------------------PLQPSTQGQSGPPGPCPRVELGASEPCTLE 650
            PPA P                        P  P++   S    P PRV    + P    
Sbjct: 709 SPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQV 768

Query: 651 HRSLESSLPPCCSQWAPATTSLIFSSQHPLCASPPICSLQSLRPPAGQAGLSNLAP 706
             S  +SLP       P           P  A+PP+ +L S  PPA   G +  +P
Sbjct: 769 PPSPPASLPMSPLAKPPPQAP-------PALATPPLQALPS--PPASFPGQAPFSP 815



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 74/276 (26%), Positives = 93/276 (33%), Gaps = 65/276 (23%)

Query: 499 GLPKPCLPE-------ECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLE--VPEPYP 549
           G P P +         E G P+P P A P PP        E P  S+    E    EP P
Sbjct: 170 GTPSPAMARRSRAAGTEVGLPRPAPSARPRPP-------TEGPRKSVSSASEHSTTEPSP 222

Query: 550 PAEPR--------------------PLESCCRS------------EPEIPESSRQEQLEV 577
            A  R                    PL S  RS             P  P+    + L  
Sbjct: 223 AARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRP 282

Query: 578 PEPCPPAEPR-----PLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGP 632
           P+  PP +       PL S     P  P  ++   +  P+      P  L PS      P
Sbjct: 283 PQVTPPRKDAAPALGPLSSSPLATPS-PSGTKARPVPPPDNAATPLPATLPPS------P 335

Query: 633 P--GPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQHPLCASPPICSLQ 690
           P   P P      S P +L+      + PP  SQ  P+ T+    +   L   PPI    
Sbjct: 336 PLATPLPLAPPSPSAPPSLQTLPSPPATPP--SQAPPSMTTPPMQAPPSLQTIPPIQVPH 393

Query: 691 SLRPPAGQAGLSNLAPRTLALRERLKS-CLTAIHCF 725
           SL  P+ QA  S LA  +L     L S  L A H F
Sbjct: 394 SLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSF 429


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 112/513 (21%), Positives = 168/513 (32%), Gaps = 100/513 (19%)

Query: 269 THSDEGGVASLGLAQRVPLRENREMSHTRDSHDSHLMPSPA--PVAQPLPGHVVPCPSPF 326
           T + +   A L L +     + ++    R       +PSP+  P+ QP PG   P   P 
Sbjct: 262 TQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKP-PAQQP- 319

Query: 327 GRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPM--PST--PRVQQAQWLRGVSPQSCSE 382
           G  +  P P  P      + + L  QP T   P+  P T  P  Q     +  + Q+ SE
Sbjct: 320 GHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSE 379

Query: 383 DPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRTPSLQEVKIQRIGILQQLL 442
            P+   EQ   +   Q        G GK P   P GP    T        Q++G  + L 
Sbjct: 380 KPSS--EQPGPKALAQP------PGVGKTPAQQP-GPAKPPT--------QQVGTPKPLA 422

Query: 443 RQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPK 502
           +Q                                               PGL   +  P 
Sbjct: 423 QQ-----------------------------------------------PGLQSPAKAPG 435

Query: 503 PC-LPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCR 561
           P   P +   P   P  + GP +   +       PS   QL  P   PP +P P     +
Sbjct: 436 PTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPS---QLPGPAKPPPQQPGP----AK 488

Query: 562 SEPEIPESSR--QEQLEVPEPCP----PAEPRPLESYCRIEPEIPESSRQEQLEVPEPCP 615
             P+ P S++   +Q    +P P    PA+P P +      P     S +   + P P  
Sbjct: 489 PPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAK 548

Query: 616 PAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIF- 674
           P+     +P +Q  SG P   P V   A +P     + L  ++ P C+     TT L+  
Sbjct: 549 PSAQQSTKPVSQTGSGKPLQPPTVSPSAKQP---PSQGLPKTICPLCN-----TTELLLH 600

Query: 675 ---SSQHPLC--ASPPICSLQSLRPPAGQAGLSNLAPRTLALRERLKSCLTAIHCFHEAR 729
               +    C      +CSL    P      +         ++  L   L  +    + +
Sbjct: 601 VPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPK 660

Query: 730 LDDECAFYTSRAPPSGPTRVCTNPVATLLEWQD 762
           L       TS    S P    T+P       QD
Sbjct: 661 LKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQD 693



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 144/663 (21%), Positives = 220/663 (33%), Gaps = 83/663 (12%)

Query: 28  KRTPFPTVTSCAVDQENQDPRRWV----QKPPLNIQRPLVDSAGPRPKARHQAETSQRLV 83
           K  PF  ++     QE    ++ V    Q  P  I +P +    P+P  + Q      L 
Sbjct: 172 KFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQ 231

Query: 84  GISQPRNPLEELRPSPRGQNVGPGPPAQ--TEAPGT----IEFVADPA----ALATILSG 133
               P++   +     + Q  G G P Q  T+ P T    +    D +      A I+ G
Sbjct: 232 QDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRG 291

Query: 134 EGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTHRLDPARASCFSR- 192
           E VK       PS +K  + + + G    +  G   S       P     PA+ S  ++ 
Sbjct: 292 ESVKP----SLPSPSKPPIQQPTPGKPPAQQPGHEKS------QPGPAKPPAQPSGLTKP 341

Query: 193 -LEGPG-------PRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRTSVSQ 244
             + PG       P G T  P +      P GP+  P+ +   ++   E  G    +   
Sbjct: 342 LAQQPGTVKPPVQPPGTTKPPAQ------PLGPAKPPAQQTGSEKPSSEQPGPKALAQPP 395

Query: 245 ASGLLLETPVQPAFSLPKGEREVVTH---SDEGGVASLGLA---QRVPLRE----NREMS 294
             G   +TP Q         ++V T    + + G+ S   A    + P+++         
Sbjct: 396 GVG---KTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQ 452

Query: 295 HTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPK 354
                  S     P      LPG   P P   G A+  P P  P        +  + +P 
Sbjct: 453 QAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAK--PPPQQPGSAKPPSQQPGSTKPP 510

Query: 355 TRFTPMPSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVA 414
            +  P P+ P  QQ    +  S Q  S  P+      A     Q +   S  GSGKP   
Sbjct: 511 PQ-QPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQP 569

Query: 415 TPSGPHSNRTPSLQEVK-IQRIGILQQLLRQEVEGLVGGQCVPLNGG-SSLDMVELQPLL 472
               P + + PS    K I  +    +LL    E      C        SL      P L
Sbjct: 570 PTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHL 629

Query: 473 TEI----------SRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGP 522
           TE+           R L        +S  P L          + +   +PQ   P +   
Sbjct: 630 TEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAA 689

Query: 523 PEAFCRSEPE-------IPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQL 575
           P+      PE       + +P+L          PP      +     EP +P    +  +
Sbjct: 690 PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPV 749

Query: 576 EVPEPCPPAEPRPL-----ESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQS 630
              +P  P   +P       S    +P+IP S  Q Q E  +  PP +    +PS   QS
Sbjct: 750 ADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAE-EKTTPPLKTDSAKPS---QS 805

Query: 631 GPP 633
            PP
Sbjct: 806 FPP 808



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 142/684 (20%), Positives = 216/684 (31%), Gaps = 133/684 (19%)

Query: 5   QATKDPLLRGVS-----PTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQ 59
           Q  +  ++RG S     P+PSK P+  Q+ TP          +++Q         P  + 
Sbjct: 282 QTKQADIVRGESVKPSLPSPSKPPI--QQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLT 339

Query: 60  RPLVDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQTEAPGTIE 119
           +PL    G          T++       P  P  +   S +  +  PGP A  + PG  +
Sbjct: 340 KPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGK 399

Query: 120 FVADPAALATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPT 179
             A                    +QP  AK    +        +  G+++ A     T T
Sbjct: 400 TPA--------------------QQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKT 439

Query: 180 HRLDPARASCFSRLEGPGPR-----GRTLCPQRLQALISPSGPSFHPSTRPSFQELRRET 234
               P      ++  GPG       G T  P +L       GP+  P  +P   +   + 
Sbjct: 440 PVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLP------GPAKPPPQQPGPAKPPPQQ 493

Query: 235 AGSSRTSVSQASGLLLETPVQPAFSLPKGEREVVTH--SDEGGVASLGLAQRVPLRENRE 292
            GS++   SQ  G     P QP  + P  ++   T   S + G A     Q  P + + +
Sbjct: 494 PGSAKPP-SQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQ 552

Query: 293 MSHTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQ 352
            S               PV+Q   G  +  P+    A++ PS G P           T+ 
Sbjct: 553 QS-------------TKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPK----------TIC 589

Query: 353 PKTRFTPM----PSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGS 408
           P    T +    P           +      C  +P     +V   L       R+L G 
Sbjct: 590 PLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGD 649

Query: 409 GKPPVATPSGPHSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVEL 468
             P    PS P     P L+   +     + +   Q  +        P    S     + 
Sbjct: 650 LAP---VPSSPQ----PKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKK 702

Query: 469 QPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCR 528
            P L +       T H S ++            +P  PE     +P PP EP  P     
Sbjct: 703 PPPLVK-----QPTLHGSPSAKAK---------QP--PEADSLSKPAPPKEPSVP----- 741

Query: 529 SEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPP----- 583
           SE +   P   ++ + P+   P       S   ++P+IP S  Q Q E  +  PP     
Sbjct: 742 SEQD-KAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAE-EKTTPPLKTDS 799

Query: 584 --------------------AEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQ 623
                               A PRP      I    P S  + Q +V       EP   Q
Sbjct: 800 AKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQ 859

Query: 624 ----------PSTQGQSGPPGPCP 637
                     P  +G   PPGP P
Sbjct: 860 TKMSPKPDAKPMPKGSPTPPGPRP 883



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 106/478 (22%), Positives = 166/478 (34%), Gaps = 95/478 (19%)

Query: 285 VPLRENREMSHTRDSHDSHLMPSPAPVAQPLP--GHVVPCPSPFGRAQRVPSPGPPTLTS 342
           + L+E++  +  ++ H S +MP        L     VV   +PF       +    T   
Sbjct: 133 ISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKK 192

Query: 343 YSVLRRLTVQPKTRFTP-------------------------MPSTPRVQQAQWLRGVSP 377
             V+++   +P+    P                          P +   QQ + ++   P
Sbjct: 193 QKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPP 252

Query: 378 ------QSCSEDP-----ALPWEQVAVR-------LFDQESCIRSLEGSGKPPV--ATPS 417
                 Q  ++ P      LP ++ A R       +   ES   SL    KPP+   TP 
Sbjct: 253 GTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPG 312

Query: 418 GP------HSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPL 471
            P      H    P   +   Q  G+ + L +Q       G   P            QP 
Sbjct: 313 KPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQP------GTVKPPVQPPGTTKPPAQP- 365

Query: 472 LTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEP 531
           L         T     +S  PG      L +P    +    QP  PA+P P +     +P
Sbjct: 366 LGPAKPPAQQTGSEKPSSEQPG---PKALAQPPGVGKTPAQQP-GPAKP-PTQQVGTPKP 420

Query: 532 EIPEPSLQEQLEVPEP--YPPAEPRPLESCCRSEPEIPESSRQ-------EQLEVPEPCP 582
              +P LQ   + P P   P  +P P +   +       S++Q        QL  P   P
Sbjct: 421 LAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPP 480

Query: 583 PAEPRPLESYCRIEPEIPESSR--QEQLEVPEPCPPAEPGPLQPSTQ--GQSGPPGPCPR 638
           P +P P     +  P+ P S++   +Q    +P PP +PGP +PS Q  G + PP   P 
Sbjct: 481 PQQPGP----AKPPPQQPGSAKPPSQQPGSTKP-PPQQPGPAKPSPQQPGSTKPPSQQP- 534

Query: 639 VELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQHPLCASPPICSLQSLRPPA 696
              G+++P   +     S   P   Q     +     S  PL   PP  S  + +PP+
Sbjct: 535 ---GSAKPSAQQ----PSPAKPSAQQSTKPVSQT--GSGKPL--QPPTVSPSAKQPPS 581



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 53/208 (25%), Positives = 79/208 (37%), Gaps = 31/208 (14%)

Query: 507 EECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPR-PLESCCRSEPE 565
           EE  + Q     E G PE        I +P LQ+Q   P P      R PL+     +  
Sbjct: 187 EETTKKQKVVQKEQGKPEG-------IIKPPLQQQPPKPIPKQQGPGRDPLQ-----QDG 234

Query: 566 IPESSRQEQLEVPEPCPPAEPRPLESYCRI----EPEIP-------ESSRQEQLEVPEPC 614
            P+S   +Q E  +  PP   +P++   +       ++P         ++Q  +   E  
Sbjct: 235 TPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESV 294

Query: 615 PPAEPGPLQPSTQGQSGPPGPCPRVELG--ASEPCTLEHRSLESSLPPCCSQWAPATTSL 672
            P+ P P +P  Q  +  PG  P  + G   S+P   +  +  S L    +Q  P T   
Sbjct: 295 KPSLPSPSKPPIQQPT--PGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQ-QPGTVKP 351

Query: 673 IFSSQHPLCASPPICSLQSLRPPAGQAG 700
               Q P    PP   L   +PPA Q G
Sbjct: 352 --PVQPPGTTKPPAQPLGPAKPPAQQTG 377



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 38/149 (25%), Positives = 49/149 (32%), Gaps = 18/149 (12%)

Query: 496  KHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRP 555
            + S L     P     P P PP  P PP       P  P+P++  + ++    P     P
Sbjct: 2395 RSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATP 2454

Query: 556  LESCCRSEPEIPESSRQEQLEVPEPC----PPAEPRP------LESYCRIEPEIPESSRQ 605
            L     +  E     R   L V   C    PP  P+P      L    R EP  P  +  
Sbjct: 2455 LFDAV-TTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIA-- 2511

Query: 606  EQLEVPEPCPPAEPGPLQPSTQGQSGPPG 634
                 P+P  P  P   Q  T     P G
Sbjct: 2512 -----PKPVIPQLPTTTQKPTDIHPKPTG 2535


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 112/513 (21%), Positives = 168/513 (32%), Gaps = 100/513 (19%)

Query: 269 THSDEGGVASLGLAQRVPLRENREMSHTRDSHDSHLMPSPA--PVAQPLPGHVVPCPSPF 326
           T + +   A L L +     + ++    R       +PSP+  P+ QP PG   P   P 
Sbjct: 262 TQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKP-PAQQP- 319

Query: 327 GRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPM--PST--PRVQQAQWLRGVSPQSCSE 382
           G  +  P P  P      + + L  QP T   P+  P T  P  Q     +  + Q+ SE
Sbjct: 320 GHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSE 379

Query: 383 DPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRTPSLQEVKIQRIGILQQLL 442
            P+   EQ   +   Q        G GK P   P GP    T        Q++G  + L 
Sbjct: 380 KPSS--EQPGPKALAQP------PGVGKTPAQQP-GPAKPPT--------QQVGTPKPLA 422

Query: 443 RQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPK 502
           +Q                                               PGL   +  P 
Sbjct: 423 QQ-----------------------------------------------PGLQSPAKAPG 435

Query: 503 PC-LPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCR 561
           P   P +   P   P  + GP +   +       PS   QL  P   PP +P P     +
Sbjct: 436 PTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPS---QLPGPAKPPPQQPGP----AK 488

Query: 562 SEPEIPESSR--QEQLEVPEPCP----PAEPRPLESYCRIEPEIPESSRQEQLEVPEPCP 615
             P+ P S++   +Q    +P P    PA+P P +      P     S +   + P P  
Sbjct: 489 PPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAK 548

Query: 616 PAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIF- 674
           P+     +P +Q  SG P   P V   A +P     + L  ++ P C+     TT L+  
Sbjct: 549 PSAQQSTKPVSQTGSGKPLQPPTVSPSAKQP---PSQGLPKTICPLCN-----TTELLLH 600

Query: 675 ---SSQHPLC--ASPPICSLQSLRPPAGQAGLSNLAPRTLALRERLKSCLTAIHCFHEAR 729
               +    C      +CSL    P      +         ++  L   L  +    + +
Sbjct: 601 VPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPK 660

Query: 730 LDDECAFYTSRAPPSGPTRVCTNPVATLLEWQD 762
           L       TS    S P    T+P       QD
Sbjct: 661 LKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQD 693



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 144/663 (21%), Positives = 220/663 (33%), Gaps = 83/663 (12%)

Query: 28  KRTPFPTVTSCAVDQENQDPRRWV----QKPPLNIQRPLVDSAGPRPKARHQAETSQRLV 83
           K  PF  ++     QE    ++ V    Q  P  I +P +    P+P  + Q      L 
Sbjct: 172 KFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQ 231

Query: 84  GISQPRNPLEELRPSPRGQNVGPGPPAQ--TEAPGT----IEFVADPA----ALATILSG 133
               P++   +     + Q  G G P Q  T+ P T    +    D +      A I+ G
Sbjct: 232 QDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRG 291

Query: 134 EGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTHRLDPARASCFSR- 192
           E VK       PS +K  + + + G    +  G   S       P     PA+ S  ++ 
Sbjct: 292 ESVKP----SLPSPSKPPIQQPTPGKPPAQQPGHEKS------QPGPAKPPAQPSGLTKP 341

Query: 193 -LEGPG-------PRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRTSVSQ 244
             + PG       P G T  P +      P GP+  P+ +   ++   E  G    +   
Sbjct: 342 LAQQPGTVKPPVQPPGTTKPPAQ------PLGPAKPPAQQTGSEKPSSEQPGPKALAQPP 395

Query: 245 ASGLLLETPVQPAFSLPKGEREVVTH---SDEGGVASLGLA---QRVPLRE----NREMS 294
             G   +TP Q         ++V T    + + G+ S   A    + P+++         
Sbjct: 396 GVG---KTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQ 452

Query: 295 HTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPK 354
                  S     P      LPG   P P   G A+  P P  P        +  + +P 
Sbjct: 453 QAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAK--PPPQQPGSAKPPSQQPGSTKPP 510

Query: 355 TRFTPMPSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVA 414
            +  P P+ P  QQ    +  S Q  S  P+      A     Q +   S  GSGKP   
Sbjct: 511 PQ-QPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQP 569

Query: 415 TPSGPHSNRTPSLQEVK-IQRIGILQQLLRQEVEGLVGGQCVPLNGG-SSLDMVELQPLL 472
               P + + PS    K I  +    +LL    E      C        SL      P L
Sbjct: 570 PTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHL 629

Query: 473 TEI----------SRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGP 522
           TE+           R L        +S  P L          + +   +PQ   P +   
Sbjct: 630 TEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAA 689

Query: 523 PEAFCRSEPE-------IPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQL 575
           P+      PE       + +P+L          PP      +     EP +P    +  +
Sbjct: 690 PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPV 749

Query: 576 EVPEPCPPAEPRPL-----ESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQS 630
              +P  P   +P       S    +P+IP S  Q Q E  +  PP +    +PS   QS
Sbjct: 750 ADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAE-EKTTPPLKTDSAKPS---QS 805

Query: 631 GPP 633
            PP
Sbjct: 806 FPP 808



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 142/684 (20%), Positives = 216/684 (31%), Gaps = 133/684 (19%)

Query: 5   QATKDPLLRGVS-----PTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQ 59
           Q  +  ++RG S     P+PSK P+  Q+ TP          +++Q         P  + 
Sbjct: 282 QTKQADIVRGESVKPSLPSPSKPPI--QQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLT 339

Query: 60  RPLVDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQTEAPGTIE 119
           +PL    G          T++       P  P  +   S +  +  PGP A  + PG  +
Sbjct: 340 KPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGK 399

Query: 120 FVADPAALATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPT 179
             A                    +QP  AK    +        +  G+++ A     T T
Sbjct: 400 TPA--------------------QQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKT 439

Query: 180 HRLDPARASCFSRLEGPGPR-----GRTLCPQRLQALISPSGPSFHPSTRPSFQELRRET 234
               P      ++  GPG       G T  P +L       GP+  P  +P   +   + 
Sbjct: 440 PVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLP------GPAKPPPQQPGPAKPPPQQ 493

Query: 235 AGSSRTSVSQASGLLLETPVQPAFSLPKGEREVVTH--SDEGGVASLGLAQRVPLRENRE 292
            GS++   SQ  G     P QP  + P  ++   T   S + G A     Q  P + + +
Sbjct: 494 PGSAKPP-SQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQ 552

Query: 293 MSHTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQ 352
            S               PV+Q   G  +  P+    A++ PS G P           T+ 
Sbjct: 553 QS-------------TKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPK----------TIC 589

Query: 353 PKTRFTPM----PSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGS 408
           P    T +    P           +      C  +P     +V   L       R+L G 
Sbjct: 590 PLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGD 649

Query: 409 GKPPVATPSGPHSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVEL 468
             P    PS P     P L+   +     + +   Q  +        P    S     + 
Sbjct: 650 LAP---VPSSPQ----PKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKK 702

Query: 469 QPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCR 528
            P L +       T H S ++            +P  PE     +P PP EP  P     
Sbjct: 703 PPPLVK-----QPTLHGSPSAKAK---------QP--PEADSLSKPAPPKEPSVP----- 741

Query: 529 SEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPP----- 583
           SE +   P   ++ + P+   P       S   ++P+IP S  Q Q E  +  PP     
Sbjct: 742 SEQD-KAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAE-EKTTPPLKTDS 799

Query: 584 --------------------AEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQ 623
                               A PRP      I    P S  + Q +V       EP   Q
Sbjct: 800 AKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQ 859

Query: 624 ----------PSTQGQSGPPGPCP 637
                     P  +G   PPGP P
Sbjct: 860 TKMSPKPDAKPMPKGSPTPPGPRP 883



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 106/478 (22%), Positives = 166/478 (34%), Gaps = 95/478 (19%)

Query: 285 VPLRENREMSHTRDSHDSHLMPSPAPVAQPLP--GHVVPCPSPFGRAQRVPSPGPPTLTS 342
           + L+E++  +  ++ H S +MP        L     VV   +PF       +    T   
Sbjct: 133 ISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKK 192

Query: 343 YSVLRRLTVQPKTRFTP-------------------------MPSTPRVQQAQWLRGVSP 377
             V+++   +P+    P                          P +   QQ + ++   P
Sbjct: 193 QKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPP 252

Query: 378 ------QSCSEDP-----ALPWEQVAVR-------LFDQESCIRSLEGSGKPPV--ATPS 417
                 Q  ++ P      LP ++ A R       +   ES   SL    KPP+   TP 
Sbjct: 253 GTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPG 312

Query: 418 GP------HSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPL 471
            P      H    P   +   Q  G+ + L +Q       G   P            QP 
Sbjct: 313 KPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQP------GTVKPPVQPPGTTKPPAQP- 365

Query: 472 LTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEP 531
           L         T     +S  PG      L +P    +    QP  PA+P P +     +P
Sbjct: 366 LGPAKPPAQQTGSEKPSSEQPG---PKALAQPPGVGKTPAQQP-GPAKP-PTQQVGTPKP 420

Query: 532 EIPEPSLQEQLEVPEP--YPPAEPRPLESCCRSEPEIPESSRQ-------EQLEVPEPCP 582
              +P LQ   + P P   P  +P P +   +       S++Q        QL  P   P
Sbjct: 421 LAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPP 480

Query: 583 PAEPRPLESYCRIEPEIPESSR--QEQLEVPEPCPPAEPGPLQPSTQ--GQSGPPGPCPR 638
           P +P P     +  P+ P S++   +Q    +P PP +PGP +PS Q  G + PP   P 
Sbjct: 481 PQQPGP----AKPPPQQPGSAKPPSQQPGSTKP-PPQQPGPAKPSPQQPGSTKPPSQQP- 534

Query: 639 VELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQHPLCASPPICSLQSLRPPA 696
              G+++P   +     S   P   Q     +     S  PL   PP  S  + +PP+
Sbjct: 535 ---GSAKPSAQQ----PSPAKPSAQQSTKPVSQT--GSGKPL--QPPTVSPSAKQPPS 581



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 53/208 (25%), Positives = 79/208 (37%), Gaps = 31/208 (14%)

Query: 507 EECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPR-PLESCCRSEPE 565
           EE  + Q     E G PE        I +P LQ+Q   P P      R PL+     +  
Sbjct: 187 EETTKKQKVVQKEQGKPEG-------IIKPPLQQQPPKPIPKQQGPGRDPLQ-----QDG 234

Query: 566 IPESSRQEQLEVPEPCPPAEPRPLESYCRI----EPEIP-------ESSRQEQLEVPEPC 614
            P+S   +Q E  +  PP   +P++   +       ++P         ++Q  +   E  
Sbjct: 235 TPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESV 294

Query: 615 PPAEPGPLQPSTQGQSGPPGPCPRVELG--ASEPCTLEHRSLESSLPPCCSQWAPATTSL 672
            P+ P P +P  Q  +  PG  P  + G   S+P   +  +  S L    +Q  P T   
Sbjct: 295 KPSLPSPSKPPIQQPT--PGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQ-QPGTVKP 351

Query: 673 IFSSQHPLCASPPICSLQSLRPPAGQAG 700
               Q P    PP   L   +PPA Q G
Sbjct: 352 --PVQPPGTTKPPAQPLGPAKPPAQQTG 377



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 38/149 (25%), Positives = 49/149 (32%), Gaps = 18/149 (12%)

Query: 496  KHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRP 555
            + S L     P     P P PP  P PP       P  P+P++  + ++    P     P
Sbjct: 2395 RSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATP 2454

Query: 556  LESCCRSEPEIPESSRQEQLEVPEPC----PPAEPRP------LESYCRIEPEIPESSRQ 605
            L     +  E     R   L V   C    PP  P+P      L    R EP  P  +  
Sbjct: 2455 LFDAV-TTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIA-- 2511

Query: 606  EQLEVPEPCPPAEPGPLQPSTQGQSGPPG 634
                 P+P  P  P   Q  T     P G
Sbjct: 2512 -----PKPVIPQLPTTTQKPTDIHPKPTG 2535


>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
          Length = 1271

 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 46/127 (36%), Positives = 58/127 (45%), Gaps = 21/127 (16%)

Query: 506 PEECGEPQPCPPAEPGP---PEAFCRSEPE-IPEPSLQEQLEVPEPYPPAEPRPLESCCR 561
           PE   EP P P  EP P   PE    S PE  PEP+L+    VPEP P   P        
Sbjct: 95  PEPATEPAPEPATEPAPEPAPEPATESAPEPTPEPALE---SVPEPAPELTP-------E 144

Query: 562 SEPEI-PESSRQEQLEV-PEPCPPAEP--RPLESYCRIEPEIPESSRQEQLEVPEPCPPA 617
             PE+ PE + +   E+ PE CP A P  RP  + C +  + P  +R+  L+   P P  
Sbjct: 145 VAPELAPEPTPEPVTELAPEFCPEAAPEFRPSPAPCLL--QCPVDTRERGLKT-SPSPSP 201

Query: 618 EPGPLQP 624
            P P  P
Sbjct: 202 SPSPRTP 208



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 54/174 (31%), Positives = 65/174 (37%), Gaps = 20/174 (11%)

Query: 502 KPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPL-ESCC 560
           +P    E   P P PP  P PP A        PEP       +PEP P   P P  E+  
Sbjct: 19  QPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEP-------IPEPCPELAPGPCPEATS 71

Query: 561 RSEPEI-----PESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLE-VPEPC 614
            S  E+     PE + +   E P P P  EP P  +        PE + +   E  PEP 
Sbjct: 72  ESATELYTEPTPEPATEPASE-PAPEPATEPAPEPATEPAPEPAPEPATESAPEPTPEPA 130

Query: 615 PPAEPGP---LQPSTQGQSGP-PGPCPRVELGASEPCTLEHRSLESSLPPCCSQ 664
             + P P   L P    +  P P P P  EL A E C         S  PC  Q
Sbjct: 131 LESVPEPAPELTPEVAPELAPEPTPEPVTEL-APEFCPEAAPEFRPSPAPCLLQ 183



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 46/155 (29%), Positives = 56/155 (36%), Gaps = 20/155 (12%)

Query: 540 EQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPL-----ESYCR 594
           E  E P P+PP  P P        P  P  S      +PEPCP   P P      ES   
Sbjct: 22  ESPEPPPPWPPPPPPPAPP-----PAPPLLSEASPEPIPEPCPELAPGPCPEATSESATE 76

Query: 595 IEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSL 654
           +  E       E    P P P  EP P +P+T+  +  P P P  E   S P      +L
Sbjct: 77  LYTEPTPEPATEPASEPAPEPATEPAP-EPATE-PAPEPAPEPATE---SAPEPTPEPAL 131

Query: 655 ESSLPPCCSQWAPATTSLIFSSQHPLCASPPICSL 689
           ES   P     AP  T  +     P     P+  L
Sbjct: 132 ESVPEP-----APELTPEVAPELAPEPTPEPVTEL 161



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 29/84 (34%), Positives = 34/84 (40%), Gaps = 7/84 (8%)

Query: 567 PESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPST 626
           P    ++  E PEP PP  P P        P  P  S      +PEPCP   PGP   +T
Sbjct: 13  PPQDGEQPAESPEPPPPWPPPPPPP--APPPAPPLLSEASPEPIPEPCPELAPGPCPEAT 70

Query: 627 QGQS----GPPGPCPRVELGASEP 646
              +      P P P  E  ASEP
Sbjct: 71  SESATELYTEPTPEPATE-PASEP 93


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
           sapiens]
          Length = 1560

 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 103/384 (26%), Positives = 131/384 (34%), Gaps = 72/384 (18%)

Query: 316 PGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTPRVQQAQWLRGV 375
           P  V    +P G  Q    P  P   +      LTVQP  +  P  STP         G+
Sbjct: 590 PSAVAMLNTPDGLVQ----PATPAAATGEAAPVLTVQPAPQAPPAVSTPLPL------GL 639

Query: 376 SPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRTPSLQEVKIQRI 435
                 + P  P  Q A     Q +  +   G    P     G   + TP+     I   
Sbjct: 640 QQPQAQQPPQAPTPQAAAP--PQATTPQPSPGLASSPEKIVLGQPPSATPTA----ILTQ 693

Query: 436 GILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLNATEHNSGTSHLPGLL 495
             LQ  L QE          PL+        E   L    S  ++A       +    + 
Sbjct: 694 DSLQMFLPQERSQQ------PLSA-------EGPHLSVPASVIVSAPPPAQDPAPATPVA 740

Query: 496 KHSGLPKPCLPEECGEPQPCP--PAE-----PGPPEAFCRSEPEIPEPS-LQEQLEVPEP 547
           K +GL  P  P+    P P P  PA      PGP      S P +P  + L +   +P P
Sbjct: 741 KGAGLG-PQAPDSQASPAPAPQIPAAAPLKGPGPS-----SSPSLPHQAPLGDSPHLPSP 794

Query: 548 YPPAEP-RPLESCCRSEPEIPESSRQEQLEVP-EPCPPAEPRPLESYCRIEPEIPESSRQ 605
           +P   P RP        P  P+S  +   E P  PCPP +  P      +         Q
Sbjct: 795 HPTRPPSRP--------PSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVI--------Q 838

Query: 606 EQLEVPEPCP---PAEPGPLQPSTQGQSGPP-GPCPRV-ELGASEPCTLEHRSLESSLPP 660
            QL VP P     P  PGP QP  + QS PP GP P    L  S   +    S E+    
Sbjct: 839 NQLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSET---- 894

Query: 661 CCSQWAPATTSLIFSSQHPLCASP 684
             S   PA T   F  Q P    P
Sbjct: 895 --SSRLPAPTPSDFQLQFPPSQGP 916



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 48/201 (23%), Positives = 73/201 (36%), Gaps = 23/201 (11%)

Query: 501 PKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSL--QEQLEVPEPYPPAEPRPLES 558
           P+   P +   PQP P     P +      P     ++  Q+ L++  P   ++ +PL +
Sbjct: 653 PQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQ-QPLSA 711

Query: 559 CCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCR---IEPEIPES--SRQEQLEVPEP 613
                 E P  S    + V  P P  +P P     +   + P+ P+S  S     ++P  
Sbjct: 712 ------EGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAA 765

Query: 614 CPPAEPGPLQPSTQGQSGPPGPCPRV---------ELGASEPCTLEHRSLESSLPPCCSQ 664
            P   PGP    +     P G  P +             S P ++     E  L PC   
Sbjct: 766 APLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPP 825

Query: 665 WAPATTSLIFSSQHPLCASPP 685
            AP T   IF  Q+ L   PP
Sbjct: 826 QAPPTLPGIFVIQNQLGVPPP 846



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 55/224 (24%), Positives = 82/224 (36%), Gaps = 35/224 (15%)

Query: 499 GLPKPCLPEEC-GEPQPCPPAEPGPPEAFCRSEP---EIPEPSLQEQLEVPEPYPPAEPR 554
           GL +P  P    GE  P    +P P      S P    + +P  Q+  + P P   A P+
Sbjct: 601 GLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQ 660

Query: 555 PLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLE----- 609
                   +P    +S  E++ + +P P A P  + +   ++  +P+   Q+ L      
Sbjct: 661 ----ATTPQPSPGLASSPEKIVLGQP-PSATPTAILTQDSLQMFLPQERSQQPLSAEGPH 715

Query: 610 --------VPEPCPPAEPGPLQPSTQGQS-GP------PGPCPRVELGASEPCTLEHRSL 654
                   V  P P  +P P  P  +G   GP        P P  ++ A+ P      S 
Sbjct: 716 LSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSS 775

Query: 655 ESSLPPCCSQWAPATTSLIFSSQHPL--CASPPICSLQSLRPPA 696
             SLP      AP   S    S HP    + PP       RPP+
Sbjct: 776 SPSLP----HQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPS 815



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 93/419 (22%), Positives = 136/419 (32%), Gaps = 81/419 (19%)

Query: 68   PRPKARHQAETSQRLVGISQPRNPLEELRPSPRG----QNVGPGP-PAQTEAPGTIEFVA 122
            P P+A     T   L G+ QP+       P+P+     Q   P P P    +P  I    
Sbjct: 623  PAPQAPPAVSTPLPL-GLQQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEKIVLGQ 681

Query: 123  DPAALATILSGEGVKSCHLGRQ----------PSLAKRVLVRGSQGGTTQR---VQGVRA 169
             P+A  T +  +      L ++          P L+    V  S     Q       V  
Sbjct: 682  PPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAK 741

Query: 170  SAYLAPRTPTHRLDPARAS---CFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPS 226
             A L P+ P  +  PA A      + L+GPGP      P +     SP  PS HP+  PS
Sbjct: 742  GAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPS 801

Query: 227  FQELRRETAGSSRT-----------SVSQASGLLL----------------------ETP 253
                R ++     +           +     G+ +                      + P
Sbjct: 802  RPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPP 861

Query: 254  VQPAFSLPKGEREVVTH----SDEGGVASLG-LAQRVPLRENREMS-HTRDSHDSHLMPS 307
            ++P    P+G      H    S    VAS    + R+P     +       S   H  P+
Sbjct: 862  LRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKSPT 921

Query: 308  PAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTPRVQ 367
            P P    +P    P P P    Q V +P P      ++L         RF  +PS   +Q
Sbjct: 922  PPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKALLE--------RFHQVPSGIILQ 973

Query: 368  QAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRTPS 426
                            PA P  Q +  L    S   S+  SG+ P  TP+ P     P+
Sbjct: 974  ----------NKAGGAPAAP--QTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPA 1020



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 57/230 (24%), Positives = 77/230 (33%), Gaps = 26/230 (11%)

Query: 501  PKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPR-PLESC 559
            P P    +  EP P PP  P PP        + P P+  E+   P    P  PR PL   
Sbjct: 1334 PPPPATLKVAEPPPRPPPPP-PPTGQMNGTVDHPPPAAPER--KPLGTAPHCPRLPLRKT 1390

Query: 560  CRSE---PEIPESSRQEQLE--VPEPCPPAEPRPLESYCRIEPEIPESSRQEQLE--VPE 612
             R     P  PE +   +     P P P           R    + +   Q  L+   PE
Sbjct: 1391 YRENVGGPGAPEGTPAGRARGGSPAPLPAKVDEATSGLIRELAAVEDELYQRMLKGPPPE 1450

Query: 613  PCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRS---------LESSLPPCCS 663
            P   A  G   P  +    PP    + E    +  +    S         L+S++    +
Sbjct: 1451 PAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFSSDSPQDDTLTEHLQSAIDSILN 1510

Query: 664  -QWAPATT---SLIFSSQHPLCASPPICSLQSLRPPAGQAGLSNLAPRTL 709
             Q AP  T   S   ++     ASPP        PP+   G   L  RTL
Sbjct: 1511 LQQAPGRTPAPSYPHAASAGTPASPPPLHRPEAYPPSSHNG--GLGARTL 1558


>gi|153792074 proline rich 12 [Homo sapiens]
          Length = 2036

 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 107/433 (24%), Positives = 156/433 (36%), Gaps = 68/433 (15%)

Query: 196  PGPRGRTLCPQRLQALISPS--GPSFHPSTRPSFQELRRETAGSSRTSVSQASGLLLET- 252
            P PRGR     R++ L  P+  GP+   +     ++ R    G  R +  +A G  LE  
Sbjct: 1168 PRPRGRP----RIRPLEVPTTAGPASASTPTDGAKKPRGRGRGRGRKA-EEAGGTRLEPL 1222

Query: 253  -PVQPAFSLPKGER-------EVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSHDSHL 304
             P++   S+PK          + ++ +D   + S    +++  +  +E+   +    S  
Sbjct: 1223 KPLKIKLSVPKAGEGLGTSSGDAISGTDHNSLDSSLTREKIEAKI-KEVEEKQPEMKSGF 1281

Query: 305  MPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTP 364
            M S     +    H      P  +A   P   PP     SV  R  +QP+   TP    P
Sbjct: 1282 MASFLDFLKSGKRH-----PPLYQAGLTPPLSPPKSVPPSVPAR-GLQPQPPATPAVPHP 1335

Query: 365  RVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRT 424
                A  L G    + SE   L       RL   E   R+LE         PS       
Sbjct: 1336 PPSGAFGLGGALEAAESEGLGLGCPSPCKRL--DEELKRNLE-------TLPS------F 1380

Query: 425  PSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLNATEH 484
             S +E  + +   LQ+ +   +  L      PL G       +  PL    +        
Sbjct: 1381 SSDEEDSVAKNRDLQESISSAISAL---DDPPLAGPKDTSTPDGPPLAPAAAVP------ 1431

Query: 485  NSGTSHLPGL--LKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQL 542
              G   LPGL     +G P+P L EE  +P P PP  P P       +P+ P P    Q 
Sbjct: 1432 --GPPPLPGLPSANSNGTPEPPLLEE--KPPPTPPPAPTP-------QPQPPPPPPPPQP 1480

Query: 543  EVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPES 602
             +P P P   P P      S P  P         +P P PP  P P  +     PE P +
Sbjct: 1481 ALPSPPPLVAPTP------SSPPPPPLPPPPPPAMPSPPPP--PPPAAAPLAAPPEEPAA 1532

Query: 603  SRQEQLEVPEPCP 615
               E  E+P+  P
Sbjct: 1533 PSPEDPELPDTRP 1545



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 85/370 (22%), Positives = 129/370 (34%), Gaps = 61/370 (16%)

Query: 305  MPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTP 364
            +PSP P+  P P    P P P      +PSP PP   + + L      P+    P P  P
Sbjct: 1482 LPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPL---AAPPEEPAAPSPEDP 1538

Query: 365  RVQQAQWLRGVSPQS----CSEDPALPWEQVAVRLF-DQESCIRSLEGSGKPPVATPSGP 419
             +   + L     Q     C E      E     +F +++  +   E      +A  +G 
Sbjct: 1539 ELPDTRPLHLAKKQETAAVCGETDEEAGESGGEGIFRERDEFVIRAEDIPSLKLALQTG- 1597

Query: 420  HSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQ---CVPLN--GGSSLDMVELQPLLTE 474
                 P +  V+       + LL++    +  GQ   C   N  G         Q L  +
Sbjct: 1598 --REPPPIWRVQ-------KALLQKFTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVK 1648

Query: 475  ISRTLNATEHNSGTS----HLPGL-LKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRS 529
                +N  ++    +    H P + ++ SG  K   P   G     PP  P PP      
Sbjct: 1649 FLENVNKKDYVRVCARKPWHRPPVPVRRSGQAKN--PVSAGGSSAPPPKAPAPP-----P 1701

Query: 530  EPEIPEPSLQE-------QLEVPEPYPPAEP---RPLESCCRSEP----------EIPES 569
            +PE PE +  E       +  +PEP  P +P   RP+E     E           E   S
Sbjct: 1702 KPETPEKTTSEKPPEQTPETAMPEPPAPEKPSLLRPVEKEKEKEKVTRGERPLRGERATS 1761

Query: 570  SRQ----EQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPS 625
             RQ      L   +P     P+   +  + EP  P   R++ L+       A  GP   S
Sbjct: 1762 GRQTRPERSLATGQPATSRLPKARPTKVKAEP--PPKKRKKWLKEAGGNATAGGGPPGSS 1819

Query: 626  TQGQSGPPGP 635
            +  +S P  P
Sbjct: 1820 SDSESSPGAP 1829



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 54/189 (28%), Positives = 68/189 (35%), Gaps = 42/189 (22%)

Query: 491 LPGLLKHSGLPKPCLPE----------ECGEPQPCPPAEPGPP------EAFCRS---EP 531
           LP +L H+  P P   +            G PQP PP  P PP      EA  RS   EP
Sbjct: 802 LPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEP 861

Query: 532 EIPEP------------SLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPE 579
             P P            ++QE L   EP PPA          SE + P  + +     P 
Sbjct: 862 AAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRS----PS 917

Query: 580 PCPPAEPR--PLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCP 637
           P     PR  PL S C      P+S  Q++     P      G       G++GPP    
Sbjct: 918 PQGTKAPRFVPLTSIC-----FPDSLLQDEERSFFPTMEEMFGGGAADDYGKAGPPEDEG 972

Query: 638 RVELGASEP 646
             + GA  P
Sbjct: 973 DPKAGAGPP 981



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 38/126 (30%), Positives = 43/126 (34%), Gaps = 36/126 (28%)

Query: 514  PCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQE 573
            P PP  PG P A   +    PEP L E  E P P PP  P                    
Sbjct: 1431 PGPPPLPGLPSA---NSNGTPEPPLLE--EKPPPTPPPAP-------------------- 1465

Query: 574  QLEVPEPCPPAEPRPLESYCRIEPEI--PESSRQEQLEVPEPCPPAEPGPLQPSTQGQSG 631
                P+P PP  P P +      P +  P  S      +P P PPA P P  P       
Sbjct: 1466 ---TPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPP------ 1516

Query: 632  PPGPCP 637
            PP   P
Sbjct: 1517 PPAAAP 1522



 Score = 33.9 bits (76), Expect = 0.59
 Identities = 38/150 (25%), Positives = 52/150 (34%), Gaps = 19/150 (12%)

Query: 493 GLLKHSGL-PKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPY--- 548
           G+L  +GL P    P   G P P PP    P +    +       + ++    P+ Y   
Sbjct: 212 GVLGPAGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSS--PQLYNFS 269

Query: 549 --PPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQE 606
              P  P P  +  R +  I    R    + P P PPA    L+ Y       P    + 
Sbjct: 270 GAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPA--HALQHYLSCGGSYPSMGHRA 327

Query: 607 QLEVPEPCPP-----AEPGPLQPSTQGQSG 631
            L     C P       PG  +PS  G SG
Sbjct: 328 NL----ACSPLGGGEPSPGAGEPSKAGPSG 353



 Score = 33.1 bits (74), Expect = 1.0
 Identities = 71/295 (24%), Positives = 99/295 (33%), Gaps = 65/295 (22%)

Query: 306  PSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTPR 365
            PSP+P A  +  H++   +  G  Q  P P PP                    PMP    
Sbjct: 810  PSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPP------------------PPMP---- 847

Query: 366  VQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSN--- 422
            +Q    LR    +  +  P L  E+        +  + +LE     P  T  GP ++   
Sbjct: 848  LQLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGK 907

Query: 423  ------RTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEIS 476
                  R+PS Q  K  R   L  +            C P              LL +  
Sbjct: 908  DPAGAYRSPSPQGTKAPRFVPLTSI------------CFP------------DSLLQDEE 943

Query: 477  RTLNAT-EHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPE 535
            R+   T E   G     G     G   P  PE+ G+P+      PGPP A+    P  P 
Sbjct: 944  RSFFPTMEEMFG----GGAADDYGKAGP--PEDEGDPKAGAGPPPGPP-AYDPYGPYCPG 996

Query: 536  PSLQEQLEVPE-PYPPAEPRPLESCCRSEP-EIPESSRQEQLEVPEPCPPAEPRP 588
             +     E P     P +P  L S   +EP  + +S   +    P P PP  P P
Sbjct: 997  RASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPPPAP 1051



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 49/202 (24%), Positives = 65/202 (32%), Gaps = 20/202 (9%)

Query: 499  GLPKPC--LPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPL 556
            G P PC  L EE        P+     E       ++ E S+   +   +  P A P+  
Sbjct: 1358 GCPSPCKRLDEELKRNLETLPSFSSDEEDSVAKNRDLQE-SISSAISALDDPPLAGPKDT 1416

Query: 557  ESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPP 616
                 S P+ P  +    +    P PP  P    +     PE P    ++    P P P 
Sbjct: 1417 -----STPDGPPLAPAAAV----PGPPPLPGLPSANSNGTPE-PPLLEEKPPPTPPPAPT 1466

Query: 617  AEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQ----WAPATTSL 672
             +P P  P    Q   P P P V   A  P +     L    PP          PA   L
Sbjct: 1467 PQPQPPPPPPPPQPALPSPPPLV---APTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPL 1523

Query: 673  IFSSQHPLCASPPICSLQSLRP 694
                + P   SP    L   RP
Sbjct: 1524 AAPPEEPAAPSPEDPELPDTRP 1545


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 116/455 (25%), Positives = 148/455 (32%), Gaps = 113/455 (24%)

Query: 307  SPAPVAQPLPGHV---VPCPSPFGRAQRVP-----SPGPPTLTSY--------------S 344
            SP  +   LP  V   VP   PFG A   P        PPT   Y              +
Sbjct: 2155 SPGELFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGA 2214

Query: 345  VLRRLTVQPKTRFTPMPSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRS 404
              R    QP    T  P TPR Q +     + P+  S D     E   V           
Sbjct: 2215 SSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGV----------- 2263

Query: 405  LEGSGKPPVATPSGPHSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLD 464
              G GK      S P    +    EVK + +G                   P  G  +L 
Sbjct: 2264 --GGGKASEPLLSPPPFGESRKALEVKKEELGASS----------------PSYGPPNLG 2305

Query: 465  MVELQPLLTEISRTLNATEHNSGTSHLPGL-LKHSGLPKPCLPEECGEPQPCPPA----- 518
             V+                 +SGT HL GL LK   + K  L     + +P  P      
Sbjct: 2306 FVD---------------SPSSGT-HLGGLELKTPDVFKAPLTPRASQVEPQSPGLGLRP 2349

Query: 519  -EPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPL----ESCC----RSEPEIPES 569
             EP P +A   S P  P+         P   PP  PRP     ESCC    RS P  P S
Sbjct: 2350 QEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFS 2409

Query: 570  ----SRQEQLEVPEPCPPAEPRPLESYC------RIEPEIPES---SRQEQLE------- 609
                S Q Q     P  P  P   E++C      R +   P S   SR +  +       
Sbjct: 2410 RVPASPQSQSSSQSPLTP-RPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHK 2468

Query: 610  VPEPCPPA---EPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWA 666
             P P PP    + G L  ++ G  G P   P      + P    H  + S  PP   + +
Sbjct: 2469 PPRPQPPEVAFKAGSLAHTSLGAGGFPAALP------AGPAGELHAKVPSGQPPNFVR-S 2521

Query: 667  PATTSLIFSSQHPLCASPPICSLQSLRPPAGQAGL 701
            P T + + +        P      SL+PP  Q GL
Sbjct: 2522 PGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGL 2556



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 67/226 (29%), Positives = 81/226 (35%), Gaps = 55/226 (24%)

Query: 505 LPEECGEPQPCPPAE-----PGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESC 559
           LPEE   PQ CP +E     P P E      PE  EP L  Q E P       P+P E C
Sbjct: 728 LPEE---PQLCPRSEGPHLSPRPEEPHLSPRPE--EPHLSPQAEEPH----LSPQPEEPC 778

Query: 560 CRSEPEIPESSRQE----------------QLEVPEPCPPAE-----PRPLESYCRIEPE 598
             + PE P  S Q                 Q E P   P  E     P+P ES+  + P+
Sbjct: 779 LCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESH--LSPQ 836

Query: 599 IPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSL 658
             E     + E     P  E  PL P  +     PG CP     A E   L     E SL
Sbjct: 837 SEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCP-----APEELPLFPPPGEPSL 891

Query: 659 PPCCSQWAPATTSLIFSSQHPLCASPPICSLQSLRP--PAGQAGLS 702
            P   +  PA +             PP+  L    P  P+G+  LS
Sbjct: 892 SPLLGE--PALSE---------PGEPPLSPLPEELPLSPSGEPSLS 926



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 64/240 (26%), Positives = 79/240 (32%), Gaps = 46/240 (19%)

Query: 503 PCLPEECGEPQPCPPAEPG---PPEAFCRSEP--EIPEPSLQEQLEVPEPY------PPA 551
           P LP     P   PP E     PPEA   S P  E+P   L E L +  P       PP 
Sbjct: 439 PLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPP 498

Query: 552 EPRPLESCCRSEPEIP----------ESSRQEQLEVPEPCPPAEPRPLESYCRIEP---- 597
           E  PL     S P  P          ES     LE P   PP E  PL       P    
Sbjct: 499 EESPLSPPPESSPFSPLEESPLSPPEESPPSPALETP-LSPPPEASPLSPPFEESPLSPP 557

Query: 598 --EIPESSRQEQLEVPEP------CPPAEPGPLQPSTQG-------QSGPPGPCPRVELG 642
             E+P S   E   +  P       PP E  P+ P  +        +  P  P P     
Sbjct: 558 PEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPE---- 613

Query: 643 ASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQHPLCASPPICSLQSLRPPAGQAGLS 702
              P +    +   S PP  S  +P       S    +    P+  +  L PP  ++ LS
Sbjct: 614 -ESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLS 672



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 56/186 (30%), Positives = 67/186 (36%), Gaps = 22/186 (11%)

Query: 516 PPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPE-------IPE 568
           PP E  P        P  P P    +L  P    P  P P +S     PE       + E
Sbjct: 664 PPPEESPLSPPPEESPTSPPPEAS-RLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEE 722

Query: 569 SSRQEQLEVPEPCPPAE-----PRPLESYCRIEPEIPESSRQEQLEVPEPCP-PAEP--- 619
           S      E P+ CP +E     PRP E +    PE P  S   Q E P   P P EP   
Sbjct: 723 SPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLS--PQAEEPHLSPQPEEPCLC 780

Query: 620 -GPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQH 678
             P +P    Q+  P   P+ E     P T E         PC S   P  + L   S+ 
Sbjct: 781 AVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSP-QPEESHLSPQSEE 839

Query: 679 PLCASP 684
           P C SP
Sbjct: 840 P-CLSP 844



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 128/537 (23%), Positives = 179/537 (33%), Gaps = 88/537 (16%)

Query: 196  PGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRTSVSQASGLLLETPVQ 255
            P P    L P    + +SP  P   P + P       E+  S    VS+ S L    PV 
Sbjct: 610  PPPEESPLSPPPEASRLSPP-PEDSPMSPPP-----EESPMSPPPEVSRLSPL----PVV 659

Query: 256  PAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSHDSHLMPSPAPVAQPL 315
               S P  E  +    +E   +        P  E   +S   +   +   P  +P + P 
Sbjct: 660  SRLSPPPEESPLSPPPEESPTS--------PPPEASRLSPPPEDSPTSPPPEDSPASPPP 711

Query: 316  PGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKT-RFTPMPSTPRVQQAQWLRG 374
               ++  P     +  +P P  P L   S    L+ +P+    +P P  P +        
Sbjct: 712  EDSLMSLP--LEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPH 769

Query: 375  VSPQSCSEDP---ALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPHSNRTPSLQEVK 431
            +SPQ   E+P   A+P E               L    + P  +P     + +P  +E  
Sbjct: 770  LSPQP--EEPCLCAVPEEP-------------HLSPQAEGPHLSPQPEELHLSPQTEEPH 814

Query: 432  IQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTE--ISRTLNATEHNSGTS 489
            +  +     L  Q  E  +  Q          +   L P L +  +S          G  
Sbjct: 815  LSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQC 874

Query: 490  HLPGLLKHSGLP-KPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIP--EPSLQEQLEVPE 546
              P  L     P +P L    GEP    P EP P        P  P  EPSL  QL  P+
Sbjct: 875  PAPEELPLFPPPGEPSLSPLLGEPALSEPGEP-PLSPLPEELPLSPSGEPSLSPQLMPPD 933

Query: 547  PYPP---------AEPR---------PLESCCRSEPEIPESSRQEQLEVPEPCPP----A 584
            P PP         A P          P  +   S+PE P ++    LE P   PP     
Sbjct: 934  PLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAA--PILETPISPPPEANCT 991

Query: 585  EPRPLESYCRIEPEIPESSRQEQLEV-PEPCPPAEPGPLQPSTQGQSGPPGPC--PRVEL 641
            +P P+     I P  P S       +  EP PP     LQ S   Q+ PP  C  P + L
Sbjct: 992  DPEPVPPM--ILPPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPL 1049

Query: 642  -------------GASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQHPL-CASP 684
                         G S+   L     E    P C    P+ TS + S    L C +P
Sbjct: 1050 SVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSPLPSPMGDLSCPAP 1106



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 58/213 (27%), Positives = 70/213 (32%), Gaps = 11/213 (5%)

Query: 490 HLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYP 549
           HL   L+ S L  P        P    P  P         E   P P+L+  L  P    
Sbjct: 484 HLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEAS 543

Query: 550 PAEPRPLESCCRSEP--EIPESSRQE--QLEVPEPCPPAEPRPLESYCRIEPEIPESSRQ 605
           P  P P E    S P  E+P S   E  +L  P    P  P P ES   + P  PE+SR 
Sbjct: 544 PLSP-PFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEES--PMSPP-PEASRL 599

Query: 606 -EQLEVPEPCPPAEPGPLQPSTQGQ--SGPPGPCPRVELGASEPCTLEHRSLESSLPPCC 662
               E     PP E  PL P  +    S PP   P        P +        S  P  
Sbjct: 600 FPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVV 659

Query: 663 SQWAPATTSLIFSSQHPLCASPPICSLQSLRPP 695
           S+ +P       S       + P      L PP
Sbjct: 660 SRLSPPPEESPLSPPPEESPTSPPPEASRLSPP 692



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 148/735 (20%), Positives = 231/735 (31%), Gaps = 177/735 (24%)

Query: 15   VSPTPSKIPVRSQKRTPFPTVTSCAVDQENQD----PRRWVQKPPLNIQR----PLVDSA 66
            +SP P + P+     +P P  +  +   E+      P      PP  + R    P+V   
Sbjct: 608  LSPPPEESPL-----SPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRL 662

Query: 67   GPRPKARHQAETSQRLVGISQPRNPLEELRPS---PRGQNVGPGPPAQTEAPGTIEFVAD 123
             P P+                P +P  E  P+   P    + P P     +P   +  A 
Sbjct: 663  SPPPE--------------ESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPAS 708

Query: 124  PAALATILSGEGVKS--CHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTHR 181
            P    +++S    +S    L  +P L  R     S+G     +       +L+PR     
Sbjct: 709  PPPEDSLMSLPLEESPLLPLPEEPQLCPR-----SEG---PHLSPRPEEPHLSPRPEEPH 760

Query: 182  LDPARASCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRTS 241
            L P           P P    LC    +  +SP     H S +P    L  +T     + 
Sbjct: 761  LSPQAEEPHL---SPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSP 817

Query: 242  VSQASGLLLETPVQPAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSHD 301
            V          P +P  S    E  +   S+E  ++        P  E   +S   +   
Sbjct: 818  V----------PEEPCLSPQPEESHLSPQSEEPCLS--------PRPEESHLSPELEK-- 857

Query: 302  SHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMP 361
                P  +P  +  P     CP+P       P PG P+L+       L+   +   +P+P
Sbjct: 858  ----PPLSPRPEKPPEEPGQCPAP-EELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLP 912

Query: 362  STPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSG--- 418
                +  +     +SPQ    DP  P              +  +  +  PP  +P G   
Sbjct: 913  EELPLSPSGE-PSLSPQLMPPDPLPP-------------PLSPIITAAAPPALSPLGELE 958

Query: 419  -PHSNRTPSLQEVKIQRIGILQQLLRQEVEGL------VGGQCVPLNGGSSL---DMVEL 468
             P   +  S  E  +    IL+  +    E        V    +P + GS +     + +
Sbjct: 959  YPFGAKGDSDPESPLAA-PILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILM 1017

Query: 469  QPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCR 528
            +PL  + S                 LL+HS +P+   P +C      PPA P        
Sbjct: 1018 EPLPPQCSP----------------LLQHSLVPQNSPPSQCS-----PPALP-------- 1048

Query: 529  SEPEIPEPSLQEQLEVPEPYPP----------AEPRPLESCCRSEPEIPESSRQEQLEVP 578
                         L VP P  P          AE   +E+   SEPE P         +P
Sbjct: 1049 -------------LSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSPLP 1095

Query: 579  EP-----CPPAEPRP-LESYCRI-----------------EPEIPESSRQEQLE------ 609
             P     CP   P P L+ +  +                 EP     S   +L+      
Sbjct: 1096 SPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPEPGQTPGSLASELKGSPVLL 1155

Query: 610  VPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPAT 669
             PE   P  P  + P  +  +G   PC   E   +         ++S +    S  +   
Sbjct: 1156 DPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTPPTLIKSDIVNEISNLSQGD 1215

Query: 670  TSLIFSSQHPLCASP 684
             S  F    PL  SP
Sbjct: 1216 ASASFPGSEPLLGSP 1230



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 54/213 (25%), Positives = 80/213 (37%), Gaps = 27/213 (12%)

Query: 511 EPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYP-PAEPRPL-ESCCRSEPEIPE 568
           EP   P  EP      C+ +P+    +    ++  EP P   E +PL ++  + EP++  
Sbjct: 376 EPGDTPTDEPDALYVACQGQPKGGHVT---SMQPKEPGPLQCEAKPLGKAGVQLEPQLEA 432

Query: 569 SSRQEQLEVPEP-----CPPAEPRPLE---SYCRIEP---EIPESSRQEQLEVPEP---- 613
              +E   +P P      PP E  P        R+ P   E+P S   E L +  P    
Sbjct: 433 PLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEES 492

Query: 614 --CPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSL--PPCCSQWAPAT 669
              PP E  PL P    +S P  P     L   E  +    +LE+ L  PP  S  +P  
Sbjct: 493 PLSPPPEESPLSPPP--ESSPFSPLEESPLSPPEE-SPPSPALETPLSPPPEASPLSPPF 549

Query: 670 TSLIFSSQHPLCASPPICSLQSLRPPAGQAGLS 702
                S       + P      L PP  ++ +S
Sbjct: 550 EESPLSPPPEELPTSPPPEASRLSPPPEESPMS 582



 Score = 37.7 bits (86), Expect = 0.041
 Identities = 37/137 (27%), Positives = 44/137 (32%), Gaps = 7/137 (5%)

Query: 506 PEECGEPQPCP---PAEPGPPEAFCRSEPEIPE---PSLQEQLEVPEPYPPAEPRPLESC 559
           P E     P P   P  P P E+     PE      P  +  L  P    P  P P  S 
Sbjct: 566 PPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASR 625

Query: 560 CRSEPE-IPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAE 618
               PE  P S   E+  +  P   +   PL    R+ P   ES      E     PP E
Sbjct: 626 LSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPE 685

Query: 619 PGPLQPSTQGQSGPPGP 635
              L P  +     P P
Sbjct: 686 ASRLSPPPEDSPTSPPP 702



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 34/123 (27%), Positives = 38/123 (30%), Gaps = 15/123 (12%)

Query: 516 PPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQL 575
           PP E  P        P  P P    +L  P    P  P P ES     PE+   S    +
Sbjct: 601 PPFEESPLSPPPEESPLSPPPEAS-RLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVV 659

Query: 576 EVPEPCP---PAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGP 632
               P P   P  P P ES     PE    S           PP E  P  P  +     
Sbjct: 660 SRLSPPPEESPLSPPPEESPTSPPPEASRLS-----------PPPEDSPTSPPPEDSPAS 708

Query: 633 PGP 635
           P P
Sbjct: 709 PPP 711



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 88/341 (25%), Positives = 126/341 (36%), Gaps = 85/341 (24%)

Query: 333  PSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTPRVQQAQWLRGVSPQ-------------- 378
            P    P+L+  S L  L VQP+ +  P PS+ ++Q    L G   Q              
Sbjct: 4062 PGEVKPSLSGDSQL--LLVQPQPQ--PQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGSHG 4117

Query: 379  -----SCSEDPALPW--EQVAVRLFDQE-SCIRSLEGSGKP----PVATPSGPHSNRT-P 425
                 S SE  ++P    Q +V L DQ  S  ++L G  +P    P+   +GP   +  P
Sbjct: 4118 QLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGP 4177

Query: 426  SLQEVK-IQRIGILQQL--LRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTE-------- 474
             LQ  + +  +GI+  +  LR +++G++      L   S     +LQ LL +        
Sbjct: 4178 VLQSGQGLPGVGIMPTVGQLRAQLQGVLAKN-PQLRHLSPQQQQQLQALLMQRQLQQSQA 4236

Query: 475  ISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIP 534
            + +T    E  + TS L GLL        C P+  G P P    + GP            
Sbjct: 4237 VRQTPPYQEPGTQTSPLQGLLG-------CQPQLGGFPGP----QTGP------------ 4273

Query: 535  EPSLQEQLEVPEPY-PPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYC 593
               LQE    P P  PP  P P  +        P          P P  P EP+      
Sbjct: 4274 ---LQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHP------TPPPSSPQEPKR----- 4319

Query: 594  RIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPG 634
                ++P  S   QL      PP  PG  +P       PPG
Sbjct: 4320 --PSQLPSPS--SQLPTEAQLPPTHPGTPKPQGPTLEPPPG 4356



 Score = 33.1 bits (74), Expect = 1.0
 Identities = 89/370 (24%), Positives = 126/370 (34%), Gaps = 78/370 (21%)

Query: 53   KPPLNIQRPLVDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQT 112
            +PP  +  P  D  G  P   H A  SQR  GI+ P     E R  P G  +G    A  
Sbjct: 2611 RPPSVLPPPAPD--GSLPYLSHGA--SQRS-GITSP----VEKREDP-GTGMGSSL-ATA 2659

Query: 113  EAPGTIEFVADPAALATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAY 172
            E PGT     DP      +SG         RQ    + +L+R      T R +   A+A 
Sbjct: 2660 ELPGT----QDPG-----MSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAA 2710

Query: 173  LAPRTP--THRLDPARASCFSRLEGPGPRGRTLCPQRLQALISP--SGPSFHPSTRPSFQ 228
                 P  +   +P+  +      G  P   T     L  L     SGP   P + PS  
Sbjct: 2711 AGAVGPPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDD 2770

Query: 229  ELRRETAGSSRTSVSQASGLLL--------ETPVQPAFSLPKGEREVVTHSDEGGVASLG 280
             L R    ++ +S+   S  L+          P   +  L + ++++          S+ 
Sbjct: 2771 RLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQQQATAATSMR 2830

Query: 281  LAQ--RVPLRENREMSHTRDSHDSHLMPSP-APVAQPLPGHVVPCPSPFGRAQRV----- 332
             A   R P     E+           + SP A ++  LPG   P P P G AQ +     
Sbjct: 2831 FAMSARFPSTPGPELGR-------QALGSPLAGISTRLPGPGEPVPGPAGPAQFIELRHN 2883

Query: 333  ------------PSPGPPTLTSYSVLRRLTVQPKTRFTPMPSTPRVQQAQWLRGVS---- 376
                        P  GPP               + RF P+   P     + LRG++    
Sbjct: 2884 VQKGLGPGGTPFPGQGPP--------------QRPRFYPVSEDPHRLAPEGLRGLAVSGL 2929

Query: 377  -PQSCSEDPA 385
             PQ  S  PA
Sbjct: 2930 PPQKPSAPPA 2939



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 28/116 (24%), Positives = 42/116 (36%), Gaps = 3/116 (2%)

Query: 523  PEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCP 582
            P+   + +  +P  +L+ QL++        P P      S      +    QL  P   P
Sbjct: 4854 PDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAP---P 4910

Query: 583  PAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPR 638
            P EP P  S     P  P +    +L       P  P PL  ++  +S  P P  R
Sbjct: 4911 PEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRAR 4966



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 90/422 (21%), Positives = 145/422 (34%), Gaps = 47/422 (11%)

Query: 243  SQASGLLLET-----PVQPAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTR 297
            S   GLL++      P  P   L   +  V+     G +   G  ++V + ++R +S   
Sbjct: 3780 SSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSS-- 3837

Query: 298  DSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGP--------PTLTSYSVLRRL 349
                    P  A   Q L GH +       + Q+    G          +L S+S   +L
Sbjct: 3838 --------PQLAQQGQGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKL 3889

Query: 350  TVQPKTRFTPMPSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSG 409
            + QP      +    ++QQ Q L+    Q   +   L  +Q+  +   Q+   +  +   
Sbjct: 3890 SAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQ 3949

Query: 410  KPPVATPSGPHSNRTPSLQEVKIQRIGIL---------QQLLRQEVEGLVGGQCVPLNGG 460
            +            +    Q+ + Q++G+L         QQ  +Q+V    G    PL   
Sbjct: 3950 QQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHF 4009

Query: 461  SSLDMVELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKP--CLPEECG-EPQPCPP 517
            SS     L P L    +  N  +    +    G   H G P      PE    EP    P
Sbjct: 4010 SSPG--ALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKP 4067

Query: 518  AEPGPPEAFCRSEPEIPEPS---LQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQ 574
            +  G  +         P+PS   LQ  L +P            +   S  ++   S  E 
Sbjct: 4068 SLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEA 4127

Query: 575  LEVP----EPCPPAEPRP-LESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQ 629
              VP    +P      +P   +   + P+ P   R  Q     P PP +PGP+  S QG 
Sbjct: 4128 SSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNT-GPQPP-KPGPVLQSGQGL 4185

Query: 630  SG 631
             G
Sbjct: 4186 PG 4187


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
            sapiens]
          Length = 1362

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 104/450 (23%), Positives = 151/450 (33%), Gaps = 106/450 (23%)

Query: 286  PLRENREMSHTRDSHDSHLMPSPAPVAQ---PLPGHVVPCPSPFGRAQRVPSPGPPTLTS 342
            P RE ++  H    H   +  +PAPV Q   P P    P P P  + Q  P P PP++  
Sbjct: 731  PGREQKKHHH---HHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSM-- 785

Query: 343  YSVLRRLTVQPKTRFTPMPSTPRVQQAQWLRGVSPQSCSE--DPALPWEQVAVRLFDQES 400
                      P+     M S+P    A  +  + PQ      DP   + Q  + L   E 
Sbjct: 786  ----------PQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPEL 835

Query: 401  CIRSLEGSGKPPVATPSGPHSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGG 460
                       P   P  P  +  P L +  +     L   L Q+          P N  
Sbjct: 836  -----------PPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSR-------PSNRA 877

Query: 461  SSLDMVELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPE------ECGEPQP 514
            ++L     +P                     P L +   LP+P + +      E  EP P
Sbjct: 878  AALPPKPARPPAVS-----------------PALTQTPLLPQPPMAQPPQVLLEDEEP-P 919

Query: 515  CPPAEPGPPEAFCRS----EPEIPE-PSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPES 569
             PP      + + +     +P  P  PS++ Q + P P PP                P  
Sbjct: 920  APPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPP---------------PHP 964

Query: 570  SRQEQLEV-PEPCPPAEPRPLESYCRIEPEIPESSRQEQL--EVPEPCPPAEPGPLQPST 626
            S Q+QL+  P P PP +P+P        P  P   +  Q    + +P PP    P  P  
Sbjct: 965  SVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPP 1024

Query: 627  QGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQHPLCA-SPP 685
              Q  PP P    ++         H+S             P +T  +  +  PL   SP 
Sbjct: 1025 GQQPPPPQPAKPQQVIQHHHSPRHHKS------------DPYSTGHLREAPSPLMIHSPQ 1072

Query: 686  ICSLQSL---RPPAGQAGLSNLAPRTLALR 712
            +   QSL    PP       N+ P+   LR
Sbjct: 1073 MSQFQSLTHQSPPQ-----QNVQPKKQELR 1097



 Score = 37.4 bits (85), Expect = 0.054
 Identities = 45/191 (23%), Positives = 72/191 (37%), Gaps = 23/191 (12%)

Query: 492 PGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPA 551
           PG+       +   P +   PQP PP     P  F    P +  P L  Q  V    P  
Sbjct: 191 PGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPF----PAV-TPDLIVQTPVMTVVP-- 243

Query: 552 EPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVP 611
            P+PL+    + P +P          P+P P   P+P++S+  I    P+  + ++  V 
Sbjct: 244 -PQPLQ----TPPPVPPQ--------PQPPPAPAPQPVQSHPPIIAATPQPVKTKK-GVK 289

Query: 612 EPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTS 671
                  P  + P  +  S PP P    +LG     +   +  +  +P      AP  +S
Sbjct: 290 RKADTTTPTTIDPIHEPPSLPPEP-KTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSS 348

Query: 672 LIFSSQHPLCA 682
            + S Q   C+
Sbjct: 349 KV-SEQLKCCS 358



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 36/126 (28%), Positives = 48/126 (38%), Gaps = 16/126 (12%)

Query: 3   TRQATKDPLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKP-PLNIQRP 61
           T QA+  P  +  +P P+  PV++    PFP VT    D   Q P   V  P PL    P
Sbjct: 199 TTQASTPPQTQ--TPQPNPPPVQATPH-PFPAVTP---DLIVQTPVMTVVPPQPLQTPPP 252

Query: 62  LVDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQTEAPGTIEFV 121
           +     P P    Q           Q   P+    P P     G    A T  P TI+ +
Sbjct: 253 VPPQPQPPPAPAPQPV---------QSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPI 303

Query: 122 ADPAAL 127
            +P +L
Sbjct: 304 HEPPSL 309


>gi|236459851 ubinuclein 2 [Homo sapiens]
          Length = 1347

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 40/127 (31%), Positives = 53/127 (41%), Gaps = 15/127 (11%)

Query: 528 RSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPR 587
           R E E P P  + + E P   P  EP+P     R+EP  P    +E     +  PP+  +
Sbjct: 17  RREAEYPGP--EREPEYPREPPRLEPQPYREPARAEPPAP----REPAPRSDAQPPSREK 70

Query: 588 PLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSG--------PPGPCPRV 639
           PL     +    P  S Q +   PEP PP  P PLQP    +S         PP    R+
Sbjct: 71  PLPQR-EVSRAEPPMSLQREPPRPEPPPPFPPLPLQPPPPRESASRAEQPPRPPRETVRL 129

Query: 640 ELGASEP 646
           EL   +P
Sbjct: 130 ELVLKDP 136



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 25/85 (29%), Positives = 37/85 (43%), Gaps = 5/85 (5%)

Query: 501 PKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPP---AEPRPLE 557
           P P  P    + QP    +P P     R+EP +       + E P P+PP     P P E
Sbjct: 52  PAPREPAPRSDAQPPSREKPLPQREVSRAEPPMSLQREPPRPEPPPPFPPLPLQPPPPRE 111

Query: 558 SCCRSE--PEIPESSRQEQLEVPEP 580
           S  R+E  P  P  + + +L + +P
Sbjct: 112 SASRAEQPPRPPRETVRLELVLKDP 136



 Score = 33.1 bits (74), Expect = 1.0
 Identities = 32/118 (27%), Positives = 41/118 (34%), Gaps = 31/118 (26%)

Query: 551 AEPR-----PLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQ 605
           AEPR      L    R E E P   R+   E P   P  EP+P     R EP        
Sbjct: 2   AEPRRVAFISLSPVRRREAEYPGPEREP--EYPREPPRLEPQPYREPARAEP-------- 51

Query: 606 EQLEVPEPCPPAEPGPLQPSTQGQSGPPG---PCPRVELGASEPCTLEHRSLESSLPP 660
                        P P +P+ +  + PP    P P+ E+  +EP     R      PP
Sbjct: 52  -------------PAPREPAPRSDAQPPSREKPLPQREVSRAEPPMSLQREPPRPEPP 96


>gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]
          Length = 2303

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 103/416 (24%), Positives = 145/416 (34%), Gaps = 64/416 (15%)

Query: 305  MPSPAPVAQP--LPGH-------VVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKT 355
            +PSPAP AQP   PG          PC +      +VPSPG     S     + +     
Sbjct: 1796 VPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATL 1855

Query: 356  RFTPMPSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVA- 414
               P  +TP  + A+     S Q+      LP ++  V          +L G G  PV  
Sbjct: 1856 SQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVT-----QAAGALPGPGASPVPK 1910

Query: 415  TPSGPHSNRTPSLQEVKIQR----IGILQQLLRQEV------------EGLVGGQCVPLN 458
            TP+     RT   ++ K QR    I  +Q+  R+               G  G +  P  
Sbjct: 1911 TPA-----RTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGA 1965

Query: 459  GGSSLDMVELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPA 518
             G  L +V +   L+  S + +     SG       +K S    P L     E      A
Sbjct: 1966 RGGRLGLVRVASALSSGSESSD----RSGFRRQLTFIKES----PGLRRRRSELSSAESA 2017

Query: 519  EPGPPEAFCR-SEPEIPE----PSLQEQLEVPEPYPPAEPRPLESCCRSEP-EIP--ESS 570
               P  A  R   P +P      S  E+L       PA  R      R  P E P   ++
Sbjct: 2018 ASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTT 2077

Query: 571  RQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQS 630
             +    +P   P A P  ++ Y  + P I  + R      P+   PA P     + +   
Sbjct: 2078 SESPSRLPVRAPAARPETVKRYASL-PHISVARR------PDGAVPAAPASADAARRSSD 2130

Query: 631  GPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATT-SLIFSSQHPLCASPP 685
            G P P PRV    + P T   R  +  +P       PAT   L  S+     A PP
Sbjct: 2131 GEPRPLPRV----AAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPP 2182



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 43/193 (22%), Positives = 64/193 (33%), Gaps = 22/193 (11%)

Query: 411  PPVATPSGPHSNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQ- 469
            PP   P GP   + P+ +    +      Q +    +    G+    + G+  +   L+ 
Sbjct: 1414 PPRDQPGGPAGRQRPTGRPTSAR------QAMGHRHKAGGAGRSAEQSRGAGKNRAGLEL 1467

Query: 470  PLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKP------CLPEECGEPQPCPPAEPGP- 522
            PL    S   +      G +   G L+   L  P      C      + +P P A P P 
Sbjct: 1468 PLGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEP-PAAAPTPT 1526

Query: 523  -------PEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQL 575
                   P AF R  P+  + +       P   PPA  +P      + P    SS    L
Sbjct: 1527 HRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSL 1586

Query: 576  EVPEPCPPAEPRP 588
              PEP  P    P
Sbjct: 1587 SEPEPSEPPAVHP 1599


>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
            sapiens]
          Length = 1636

 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 75/271 (27%), Positives = 93/271 (34%), Gaps = 49/271 (18%)

Query: 469  QPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCR 528
            QPL T  +    A +      H    +  +G P P +      PQP P  +P P +AF  
Sbjct: 916  QPLPTPYTYPAGAKQPIPAQHHFSSGIP-AGFPAPRIG-----PQPQPHPQPHPSQAFGP 969

Query: 529  SEPEIPEPSLQEQLEVPE---------PYPPA--------EPRPLESCCRSEP-EIPESS 570
              P+ P P     L  P+         PYP A         P PL +     P + P  +
Sbjct: 970  QPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQDPLPA 1029

Query: 571  RQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQS 630
                L  P P PP  P P  +Y       P          P+  P    G   PS+ GQS
Sbjct: 1030 HSGALPFPSPGPPQPPHPPLAYGPAPSTRPMG--------PQAAPLTIRG---PSSAGQS 1078

Query: 631  GP-----PGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFS--SQHPLCAS 683
             P     P P P    G   P     R   +  PPC  + A A   L  S  SQH    S
Sbjct: 1079 TPSPHLVPSPAPSPGPGPVPP-----RPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQS 1133

Query: 684  PPICSLQSLRPPAGQAGLSNLAPRTLALRER 714
            P     Q L  P          P+ L L ER
Sbjct: 1134 PG--GGQPLLQPTKVDAAEGRRPQALRLIER 1162



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 37/139 (26%), Positives = 52/139 (37%), Gaps = 21/139 (15%)

Query: 500  LPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESC 559
            +P    P     P P PP  P PP          P+P     L  P  YP    +P+ + 
Sbjct: 891  IPSHTAPRPNPTPAPPPPCFPVPP----------PQP-----LPTPYTYPAGAKQPIPAQ 935

Query: 560  CRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQL---EVPEPCPP 616
                  IP      ++  P+P P  +P P +++    P+ P   +   L   + P   PP
Sbjct: 936  HHFSSGIPAGFPAPRIG-PQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPP 994

Query: 617  AEPGPL--QPSTQGQSGPP 633
              P P   QP   GQ  PP
Sbjct: 995  QSPYPYAPQPGVLGQPPPP 1013



 Score = 33.9 bits (76), Expect = 0.59
 Identities = 48/180 (26%), Positives = 66/180 (36%), Gaps = 48/180 (26%)

Query: 490  HLPGLLKHSGLPKPCLP-------EECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQL 542
            H+  +L+  G+P PC P       ++   PQ       G        +  I + S++   
Sbjct: 1452 HVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPG 1511

Query: 543  EVPEPYP----PAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPE 598
             +  P      PAEP          P +P +S  E   +P   PP    PL       PE
Sbjct: 1512 GLESPVASLPGPAEP----------PGLPPASLPESTPIPSSSPPPLSSPL-------PE 1554

Query: 599  IPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSL 658
             P+         P+  PP    P        SGPP     +EL AS   T E  SL+SSL
Sbjct: 1555 APQ---------PKEEPPVPEAP-------SSGPPS--SSLELLAS--LTPEAFSLDSSL 1594



 Score = 33.5 bits (75), Expect = 0.78
 Identities = 30/97 (30%), Positives = 43/97 (44%), Gaps = 13/97 (13%)

Query: 442  LRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEIS-RTLNATEHNSGTSHLPGLLKHSGL 500
            L Q+ + LV G  VP++         +Q  + ++S R     E  S  + LPG  +  GL
Sbjct: 1480 LPQDSQDLVLGGDVPISS--------IQATIAKLSIRPPGGLE--SPVASLPGPAEPPGL 1529

Query: 501  PKPCLPEECGEPQPCPP--AEPGPPEAFCRSEPEIPE 535
            P   LPE    P   PP  + P P     + EP +PE
Sbjct: 1530 PPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPE 1566



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 45/195 (23%), Positives = 69/195 (35%), Gaps = 45/195 (23%)

Query: 524 EAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPP 583
           ++ C++     +  L  +L+   P  P  P+PL         +P     E +E  +  PP
Sbjct: 694 QSTCQAREAARQQLLDRELKKKPPPRPTAPKPL---------LPRREESEAVEAGD--PP 742

Query: 584 AEPRPLESYCRIEPEIPESSRQEQLEV---PEPCPPAE-------PGPLQPSTQGQSGPP 633
            E R L       P +P++       +   P P P +         GPL P T       
Sbjct: 743 EELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSSTGPGPHYLSGPLPPGTYS----- 797

Query: 634 GPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLI-----FSSQHPLCAS----- 683
           GP   ++  A  P  +      +  P      APA T  +      S QH + +S     
Sbjct: 798 GPTQLIQPRAPGPHAMPVAPGPALYP------APAYTPELGLVPRSSPQHGVVSSPYVGV 851

Query: 684 ---PPICSLQSLRPP 695
              PP+  L S  PP
Sbjct: 852 GPAPPVAGLPSAPPP 866



 Score = 30.4 bits (67), Expect = 6.6
 Identities = 26/86 (30%), Positives = 28/86 (32%), Gaps = 19/86 (22%)

Query: 303  HLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPMPS 362
            H    P P   PLP H    P         PSPGPP              P   + P PS
Sbjct: 1015 HTQLYPGPAQDPLPAHSGALP--------FPSPGPPQ----------PPHPPLAYGPAPS 1056

Query: 363  T-PRVQQAQWLRGVSPQSCSEDPALP 387
            T P   QA  L    P S  +    P
Sbjct: 1057 TRPMGPQAAPLTIRGPSSAGQSTPSP 1082


>gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]
          Length = 1243

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 43/137 (31%), Positives = 53/137 (38%), Gaps = 15/137 (10%)

Query: 514  PCP-----PAEPGPPEAFCRSEPEIPEPSLQEQLEVPEP-----YPPAEPRPLESCCRSE 563
            PCP     P+    P     S   +   ++ + L  P P      PPA P PL S     
Sbjct: 908  PCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLPLPP 967

Query: 564  PEIP---ESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQ--EQLEVPEPCPPAE 618
            P  P   ES      EV     P   RPL    R+ P   E   Q   + +V     PAE
Sbjct: 968  PVAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGKPQLVGRFQVTSSKEPAE 1027

Query: 619  PGPLQPSTQGQSGPPGP 635
            P PLQP++   SG P P
Sbjct: 1028 PLPLQPTSPTLSGSPKP 1044



 Score = 37.7 bits (86), Expect = 0.041
 Identities = 54/216 (25%), Positives = 72/216 (33%), Gaps = 31/216 (14%)

Query: 506 PEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPE----PYPPAEPRPLESCCR 561
           P E  E    P  EP P  A     P+     LQ    +       +  +   P      
Sbjct: 754 PMEAAEDTLSPQEEPAPLPALPVPLPDPSNEELQSSTSLEHRSWTAFSTSSSSPGTPLSP 813

Query: 562 SEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGP 621
             P  P +        P   PP  P P        P  P SS+      P P P + P P
Sbjct: 814 GNPFSPGTPISPGPIFPITSPPCHPSP-------SPFSPISSQVSSN--PSPHPTSSPLP 864

Query: 622 LQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSL-----PPCCSQWAPATTSLIFSS 676
              ST     P   CP   L  + P T      + +L     PPC     P+T+S   ++
Sbjct: 865 FSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVTLSSPFFPPC-----PSTSSFPSTT 919

Query: 677 QHPLCASPPICSL------QSLRPPAGQAGLSNLAP 706
             PL +     SL      QSL  P+   GL + +P
Sbjct: 920 AAPLLSLASAFSLAVMTVAQSLLSPS--PGLLSQSP 953



 Score = 34.3 bits (77), Expect = 0.45
 Identities = 39/125 (31%), Positives = 44/125 (35%), Gaps = 23/125 (18%)

Query: 456  PLNGGSSLDMVELQPLLTEISRTLNA--TEHNSGTSHLPGLLKHSG-----------LPK 502
            P    SS       PLL+  S    A  T   S  S  PGLL  S            LP 
Sbjct: 908  PCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLPLPP 967

Query: 503  PCLPEECGEPQPC----------PPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAE 552
            P  P     P P           PPA P P EA      E  +P L  + +V     PAE
Sbjct: 968  PVAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGKPQLVGRFQVTSSKEPAE 1027

Query: 553  PRPLE 557
            P PL+
Sbjct: 1028 PLPLQ 1032



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 16/31 (51%), Positives = 16/31 (51%), Gaps = 1/31 (3%)

Query: 505 LPEECGEPQPCPPAEPGPPEAFCRSEPEIPE 535
           LP E G P    P  PGPP  F   EPE PE
Sbjct: 533 LPPEPGPPPATVPMAPGPPSVF-PPEPEEPE 562


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 47/157 (29%), Positives = 65/157 (41%), Gaps = 33/157 (21%)

Query: 500   LPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPE-PSLQEQLEVPEPYPPAEPRPL-- 556
             +PK  +PE+         A P  PE      PE+P+ P L+E+  VP P     P P   
Sbjct: 10752 VPKEVVPEK-------KVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVY 10804

Query: 557   ---ESCCRSEPEIPESSR------QEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQ 607
                E     E   PE  +      +E+ EVP P  P EP+ +         IPE  +   
Sbjct: 10805 EEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKI---------IPE-KKVPV 10854

Query: 608   LEVPEPCPPAEPGP----LQPSTQGQSGPPGPCPRVE 640
             ++ PE  PP EP P     +P  + +  PP P P  E
Sbjct: 10855 IKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKE 10891



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 46/135 (34%), Positives = 65/135 (48%), Gaps = 22/135 (16%)

Query: 501   PKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCC 560
             PK  +PE+     P PPA+   PEA     PE P+  + E+ +VP P PP +P   E   
Sbjct: 10501 PKEVVPEK---KVPVPPAKK--PEAPPPKVPEAPKEVVPEK-KVPVP-PPKKP---EVPP 10550

Query: 561   RSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPG 620
                PE+P+++  E+ +VPE  PP    P        PE+PE+ ++    VPE   PA P 
Sbjct: 10551 TKVPEVPKAAVPEK-KVPEAIPPKPESP-------PPEVPEAPKE---VVPEKKVPAAP- 10598

Query: 621   PLQPSTQGQSGPPGP 635
             P +P       P  P
Sbjct: 10599 PKKPEVTPVKVPEAP 10613



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 43/147 (29%), Positives = 63/147 (42%), Gaps = 15/147 (10%)

Query: 501   PKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCC 560
             PK  +PE+     P PP  P  PE      PE+P+ ++ E+ +VPE  PP    P     
Sbjct: 10613 PKEVVPEK---KVPVPP--PKKPEVPPTKVPEVPKVAVPEK-KVPEAIPPKPESPPPEVF 10666

Query: 561   RSEPEIP-ESSRQEQLEVPEPC-------PPAEPRPLESYCRIEPEIPESSRQEQLEVPE 612
                 E+  E    E +E PEP        PP +P P +    +  + PE    +  EVP+
Sbjct: 10667 EEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPK 10726

Query: 613   PCPPAEPGPLQPSTQGQSGPPGPCPRV 639
                P +  PL    + ++ PP   P V
Sbjct: 10727 EVVPEKKVPLVVPKKPEA-PPAKVPEV 10752



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 45/160 (28%), Positives = 70/160 (43%), Gaps = 32/160 (20%)

Query: 501   PKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCC 560
             PK  +PE+     P PP  P  PE      PE+P+ ++ E+ +VPE  PP    P     
Sbjct: 10529 PKEVVPEK---KVPVPP--PKKPEVPPTKVPEVPKAAVPEK-KVPEAIPPKPESP----- 10577

Query: 561   RSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPG 620
                PE+PE+ ++    VPE   PA P          P+ PE +  +  E P+   P +  
Sbjct: 10578 --PPEVPEAPKEV---VPEKKVPAAP----------PKKPEVTPVKVPEAPKEVVPEKKV 10622

Query: 621   PLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPP 660
             P+ P  + +  PP   P V   A     +  + +  ++PP
Sbjct: 10623 PVPPPKKPEV-PPTKVPEVPKVA-----VPEKKVPEAIPP 10656



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 42/122 (34%), Positives = 56/122 (45%), Gaps = 10/122 (8%)

Query: 501   PKPCLPEECGEPQP---CPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLE 557
             P P +PE   E  P    P A P  PE      PE P+  + E+ +VP P PP +P   E
Sbjct: 10577 PPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEK-KVPVP-PPKKP---E 10631

Query: 558   SCCRSEPEIPESSRQEQLEVPEPCPP-AEPRPLESYCRIEPEIPESSRQEQLEVPEPCPP 616
                   PE+P+ +  E+ +VPE  PP  E  P E +   E    E    E +E PEP  P
Sbjct: 10632 VPPTKVPEVPKVAVPEK-KVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAP 10690

Query: 617   AE 618
              +
Sbjct: 10691 PQ 10692



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 47/180 (26%), Positives = 74/180 (41%), Gaps = 31/180 (17%)

Query: 500   LPKPCLPEECGEPQPCPPAEPGPPEAF---------CRSEPEIPEPSLQEQLEVP----- 545
             + KP L      P P PP E    + F            +P++PE      L+VP     
Sbjct: 10872 IEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKK 10931

Query: 546   --EPYPPAEPRP-----LESCCRSEPEIPESSRQ-EQLE------VPEPCPPAEPRPLE- 590
               +  P  +P P     L+S  R  PE  E   + ++LE      VPEP PP     +E 
Sbjct: 10932 VRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEV 10991

Query: 591   -SYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTL 649
              +  + E +IPE ++  +++   P P  EP P +P  + ++  P P        + P T+
Sbjct: 10992 PTVTKRERKIPEPTKVPEIKPAIPLPAPEPKP-KPEAEVKTIKPPPVEPEPTPIAAPVTV 11050



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 44/150 (29%), Positives = 62/150 (41%), Gaps = 21/150 (14%)

Query: 500   LPKPCLPEECGEPQPCPPA-EPGPPEAFCRSEPEIPEPSLQEQLEVPEP-------YPPA 551
             +PK  +PE+   P+  PP  E  PPE F   E    E    E +E PEP        PP 
Sbjct: 10640 VPKVAVPEK-KVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPK 10698

Query: 552   EPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVP 611
             +P P +       + PE    +  EVP+   P +  PL     + P+ PE+   +  EVP
Sbjct: 10699 KPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPL-----VVPKKPEAPPAKVPEVP 10753

Query: 612   EPCPPAE--PGPLQPSTQGQSGPPGPCPRV 639
             +   P +    P +P       PP   P V
Sbjct: 10754 KEVVPEKKVAVPKKPEV-----PPAKVPEV 10778



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 43/154 (27%), Positives = 59/154 (38%), Gaps = 15/154 (9%)

Query: 500   LPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEP-SLQEQLEV---PEPYPPAEPRP 555
             +PK  +PEE  +P P P     PP    +    +P P +L ++ EV    E  P  E  P
Sbjct: 10063 VPKKLIPEE-KKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLP 10121

Query: 556   LESCCRSEPEIPESSRQEQLEVPEPCPPAEPR--PLESYCRIEPE-IPESSRQEQLEVPE 612
              E     E E      +E L   E  PP E    P E Y   E E +PE     +++   
Sbjct: 10122 EEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKV 10181

Query: 613   PCPPAEPGPLQPSTQ-------GQSGPPGPCPRV 639
             P P   P   +  T+        +  PP   P V
Sbjct: 10182 PVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEV 10215



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 38/134 (28%), Positives = 54/134 (40%), Gaps = 19/134 (14%)

Query: 528  RSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPR 587
            R EP    P L E+    E  P   P+ +E      PE+P+    E+ + P P P  EP 
Sbjct: 9281 RVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEE-KKPVPVPKKEP- 9338

Query: 588  PLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELG--ASE 645
                     P++P        EVP+   P E  P+ P  + +  PP   P V+ G    E
Sbjct: 9339 ------AAPPKVP--------EVPKKPVPEEKIPV-PVAKKKEAPPAKVPEVQKGVVTEE 9383

Query: 646  PCTLEHRSLESSLP 659
              T+  +  ES  P
Sbjct: 9384 KITIVTQREESPPP 9397



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 44/173 (25%), Positives = 69/173 (39%), Gaps = 26/173 (15%)

Query: 505   LPEECGEPQPCPPAEPGPPEAFCRSEPE-IPE----PSLQEQLEVPEPYPPAE------- 552
             LPEE  E  P    E  P E +   E E +PE    P ++ ++ VP P P  +       
Sbjct: 10141 LPEE--EEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKK 10198

Query: 553   ---PRPLESCCRSEPEIPESSRQEQLEVP---EPCPPAEPRPLESYCRIEPEIPESSRQE 606
                P+  E+     PE+P+   ++++ +P   E  P       E     E EIPE     
Sbjct: 10199 VVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSI 10258

Query: 607   QLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLP 659
             + EV E  PP  P  ++ +      P  P P  +   + P  +  +  E  +P
Sbjct: 10259 E-EVEEVAPPRVPEVIKKAV-----PEAPTPVPKKVEAPPAKVSKKIPEEKVP 10305



 Score = 37.0 bits (84), Expect = 0.070
 Identities = 37/147 (25%), Positives = 60/147 (40%), Gaps = 26/147 (17%)

Query: 500   LPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESC 559
             +P+  +PEE  +P P P  +  PP        ++PE   + + +VP   P  E  P    
Sbjct: 9953  VPRKPVPEE-KKPVPVPKKKEAPPA-------KVPEVPKKPEEKVPVLIPKKEKPPPAKV 10004

Query: 560   CRSEPEIPESSRQEQLEVPEPCP-------------PAEPRPLESYCRIEPEIPESSRQE 606
                 PE+P+    E+ +VP P P             P +P P +      P+  E+   +
Sbjct: 10005 ----PEVPKKPVPEE-KVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAK 10059

Query: 607   QLEVPEPCPPAEPGPLQPSTQGQSGPP 633
               EVP+   P E  P     + ++ PP
Sbjct: 10060 VPEVPKKLIPEEKKPTPVPKKVEAPPP 10086



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 40/153 (26%), Positives = 63/153 (41%), Gaps = 25/153 (16%)

Query: 506   PEECGEPQ-PCPPAEPGPPE---AFCRSEPEIPE---PSLQEQLEVPEPYPPAEPRPLES 558
             PE    PQ   PP +P P +   A    +PE+P    P + +++   +  P   P+  E+
Sbjct: 10685 PEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEA 10744

Query: 559   CCRSEPEIP-ESSRQEQLEVPEP--CPPAEPRPLESYCRIE-------PEIPESSRQEQL 608
                  PE+P E   ++++ VP+    PPA+   +     +E       PE  ES   E  
Sbjct: 10745 PPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVY 10804

Query: 609   EVPEPCPPAE--------PGPLQPSTQGQSGPP 633
             E PE   P E        P P+    + +  PP
Sbjct: 10805 EEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPP 10837



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 38/154 (24%), Positives = 67/154 (43%), Gaps = 26/154 (16%)

Query: 501  PKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPL---E 557
            P P +PE         P +P P E      P+  EP   +  EVP+   P E +P+   +
Sbjct: 9284 PPPKVPEL--------PEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPK 9335

Query: 558  SCCRSEPEIPESSR----QEQLEVP----EPCPPAEPRPLESYCRIEPEIPESSRQEQL- 608
                + P++PE  +    +E++ VP    +  PPA+   ++     E +I   +++E+  
Sbjct: 9336 KEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESP 9395

Query: 609  -----EVPEPCPPAEPGPLQPSTQGQSGPPGPCP 637
                 E+P+   P E  P+ P  + +  PP   P
Sbjct: 9396 PPAVPEIPKKKVPEERKPV-PRKEEEVPPPPKVP 9428



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 33/123 (26%), Positives = 55/123 (44%), Gaps = 13/123 (10%)

Query: 500  LPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPE--IPEPSLQEQLEVPEPYPPAEPRPLE 557
            +P   +PEE   P P  P  P P +   ++ PE  +P P + ++L+ P P  P EP+ + 
Sbjct: 9793 IPVKPVPEE---PVPTKPKAP-PAKVLKKAVPEEKVPVP-IPKKLKPPPPKVPEEPKKV- 9846

Query: 558  SCCRSEPEIPES-SRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPP 616
                 E +I  S +++E+ +V EP      +P       +  +P       + VPE    
Sbjct: 9847 ----FEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKE 9902

Query: 617  AEP 619
             EP
Sbjct: 9903 LEP 9905



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 31/124 (25%), Positives = 50/124 (40%), Gaps = 7/124 (5%)

Query: 512   PQPCPPAEPG--PPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPES 569
             P+  PPA+    P +     +  +PE       +VPE  PP E  P +       + PE+
Sbjct: 10461 PRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEA 10520

Query: 570   SRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQPSTQGQ 629
                +  E P+   P +  P+       P+ PE    +  EVP+   P +  P     + +
Sbjct: 10521 PPPKVPEAPKEVVPEKKVPVPP-----PKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPE 10575

Query: 630   SGPP 633
             S PP
Sbjct: 10576 SPPP 10579



 Score = 34.3 bits (77), Expect = 0.45
 Identities = 36/132 (27%), Positives = 56/132 (42%), Gaps = 24/132 (18%)

Query: 503   PCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYP------------- 549
             P  PEE   P   P  E  PP       PE+P+  + E+ +VP P P             
Sbjct: 9982  PKKPEE-KVPVLIPKKEKPPPAKV----PEVPKKPVPEE-KVPVPVPKKVEAPPAKVPEV 10035

Query: 550   PAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIE---PEIPESSRQE 606
             P +P P +      P+  E+   +  EVP+   P E +P     ++E   P++P+  ++E
Sbjct: 10036 PKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPK--KRE 10093

Query: 607   QLEVPEPCPPAE 618
              + VP   P  E
Sbjct: 10094 PVPVPVALPQEE 10105



 Score = 33.9 bits (76), Expect = 0.59
 Identities = 31/120 (25%), Positives = 52/120 (43%), Gaps = 20/120 (16%)

Query: 502   KPCLPEECGEPQPC-----PPAEPGPPEAFCRSEPEIPEPSLQE--------QLEVPEPY 548
             +P   EE  E  P        A P  PE   ++ PE P P  ++          ++PE  
Sbjct: 10244 EPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEK 10303

Query: 549   PPAEPRPLESCCRSEPEIPESSRQEQLEVP--EPCPPAEPRPLESYCRIEPEIPESSRQE 606
              P   +  E+     PE+P+   ++++ VP  E  PPA+ R +     +E ++  + RQE
Sbjct: 10304 VPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTV-----LEEKVSVAFRQE 10358



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 29/114 (25%), Positives = 44/114 (38%), Gaps = 16/114 (14%)

Query: 507   EECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEI 566
             EE    +  P   P   E    + P +PE   +   E P P P     P     +  PE 
Sbjct: 10243 EEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPE- 10301

Query: 567   PESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVP--EPCPPAE 618
                   E++ VP     A P  +       PE+P+   ++++ VP  E  PPA+
Sbjct: 10302 ------EKVPVPVQKKEAPPAKV-------PEVPKKVPEKKVLVPKKEAVPPAK 10342



 Score = 30.0 bits (66), Expect = 8.6
 Identities = 32/113 (28%), Positives = 46/113 (40%), Gaps = 29/113 (25%)

Query: 511   EPQPCPPAEPGPPEAFCRSEPEIPE--PSLQEQLEVPEPYPPAEPRPLESCCRSEPEIPE 568
             E +  P      PE    SE EIPE  PS++E  EV                 + P +PE
Sbjct: 10229 EEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEV-----------------APPRVPE 10271

Query: 569   SSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVP---EPCPPAE 618
               ++   E P P P     P     ++  +IPE    E++ VP   +  PPA+
Sbjct: 10272 VIKKAVPEAPTPVPKKVEAP---PAKVSKKIPE----EKVPVPVQKKEAPPAK 10317


>gi|14602439 Williams Beuren syndrome chromosome region 14 isoform
           delta [Homo sapiens]
          Length = 831

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 77/279 (27%), Positives = 98/279 (35%), Gaps = 53/279 (18%)

Query: 474 EISRTLNATEHNSGTSHL------PGLLKHSGL----------PKPCLPEECGEPQPCPP 517
           E+    +A  H SG S L      PG L  S            PKP LP     P P PP
Sbjct: 339 EVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLP-----PPPVPP 393

Query: 518 A-------------EPGPPEAFCRSEPEIPEPSLQEQ-LEVPE-PYPPAEPRPLESCCRS 562
                         EP PP  F    P  P   LQE+ L  P  P+P   P P  S   +
Sbjct: 394 PLLHYPPPAKVPGLEPCPPPPFPPMAP--PTALLQEEPLFSPRFPFPTVPPAPGVSPLPA 451

Query: 563 EPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCP---PAEP 619
               P + +     VP P P   P  L      EP         + + P P P    A P
Sbjct: 452 PAAFPPTPQS----VPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASP 507

Query: 620 GPLQPSTQGQ---SGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSS 676
             L P+T      +G   PC    L A++P     ++LE  L       +P +       
Sbjct: 508 PTLAPATASPPTTAGSNNPCLTQLLTAAKP----EQALEPPLVSSTLLRSPGSPQETVP- 562

Query: 677 QHPLCASPPICSLQSLRPPAGQAGLSNLAPRTLALRERL 715
           + P    PP  +    RPP G A L+   P  +   ERL
Sbjct: 563 EFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERL 601



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 66/282 (23%), Positives = 92/282 (32%), Gaps = 63/282 (22%)

Query: 468 LQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFC 527
           +QP LT +  +L+          +     +S LP+P +P    EP   P   P     F 
Sbjct: 282 IQPDLTPLQPSLD------DFMDISDFFTNSRLPQPPMPSNFPEP---PSFSPVVDSLFS 332

Query: 528 RSE--PEIPEPS-----------LQEQLEVPEPYP-----------PAEPRPLESCCRSE 563
                PE+P  S           LQ +   P P             P +P+P        
Sbjct: 333 SGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVP 392

Query: 564 PEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGP-- 621
           P +       ++   EPCPP    P+     +  E P  S +       P P   P P  
Sbjct: 393 PPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAP 452

Query: 622 --LQPSTQGQSGP---PGPCPRVELGASEPCTLEHRSLESSLPPCCS---------QWAP 667
               P+ Q    P   P P   + LG SEP      S+    PP  S           AP
Sbjct: 453 AAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAP 512

Query: 668 AT--------------TSLIFSSQHPLCASPPICSLQSLRPP 695
           AT              T L+ +++      PP+ S   LR P
Sbjct: 513 ATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSP 554


>gi|14602437 Williams Beuren syndrome chromosome region 14 isoform
           gamma [Homo sapiens]
          Length = 850

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 77/279 (27%), Positives = 98/279 (35%), Gaps = 53/279 (18%)

Query: 474 EISRTLNATEHNSGTSHL------PGLLKHSGL----------PKPCLPEECGEPQPCPP 517
           E+    +A  H SG S L      PG L  S            PKP LP     P P PP
Sbjct: 339 EVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLP-----PPPVPP 393

Query: 518 A-------------EPGPPEAFCRSEPEIPEPSLQEQ-LEVPE-PYPPAEPRPLESCCRS 562
                         EP PP  F    P  P   LQE+ L  P  P+P   P P  S   +
Sbjct: 394 PLLHYPPPAKVPGLEPCPPPPFPPMAP--PTALLQEEPLFSPRFPFPTVPPAPGVSPLPA 451

Query: 563 EPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCP---PAEP 619
               P + +     VP P P   P  L      EP         + + P P P    A P
Sbjct: 452 PAAFPPTPQS----VPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASP 507

Query: 620 GPLQPSTQGQ---SGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSS 676
             L P+T      +G   PC    L A++P     ++LE  L       +P +       
Sbjct: 508 PTLAPATASPPTTAGSNNPCLTQLLTAAKP----EQALEPPLVSSTLLRSPGSPQETVP- 562

Query: 677 QHPLCASPPICSLQSLRPPAGQAGLSNLAPRTLALRERL 715
           + P    PP  +    RPP G A L+   P  +   ERL
Sbjct: 563 EFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERL 601



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 66/282 (23%), Positives = 92/282 (32%), Gaps = 63/282 (22%)

Query: 468 LQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFC 527
           +QP LT +  +L+          +     +S LP+P +P    EP   P   P     F 
Sbjct: 282 IQPDLTPLQPSLD------DFMDISDFFTNSRLPQPPMPSNFPEP---PSFSPVVDSLFS 332

Query: 528 RSE--PEIPEPS-----------LQEQLEVPEPYP-----------PAEPRPLESCCRSE 563
                PE+P  S           LQ +   P P             P +P+P        
Sbjct: 333 SGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVP 392

Query: 564 PEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGP-- 621
           P +       ++   EPCPP    P+     +  E P  S +       P P   P P  
Sbjct: 393 PPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAP 452

Query: 622 --LQPSTQGQSGP---PGPCPRVELGASEPCTLEHRSLESSLPPCCS---------QWAP 667
               P+ Q    P   P P   + LG SEP      S+    PP  S           AP
Sbjct: 453 AAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAP 512

Query: 668 AT--------------TSLIFSSQHPLCASPPICSLQSLRPP 695
           AT              T L+ +++      PP+ S   LR P
Sbjct: 513 ATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSP 554


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,960,377
Number of Sequences: 37866
Number of extensions: 3107599
Number of successful extensions: 21869
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 123
Number of HSP's successfully gapped in prelim test: 1163
Number of HSP's that attempted gapping in prelim test: 13564
Number of HSP's gapped (non-prelim): 7184
length of query: 778
length of database: 18,247,518
effective HSP length: 110
effective length of query: 668
effective length of database: 14,082,258
effective search space: 9406948344
effective search space used: 9406948344
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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