Search of human proteins with 153251229

Search of human proteins with 153251229

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|153251229 chondroadherin precursor [Homo sapiens]
         (359 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|153251229 chondroadherin precursor [Homo sapiens]                  727   0.0  
gi|194440719 chondroadherin-like [Homo sapiens]                       255   5e-68
gi|198041768 synleurin [Homo sapiens]                                 162   3e-40
gi|51317373 netrin-G1 ligand [Homo sapiens]                           154   9e-38
gi|12007646 nyctalopin precursor [Homo sapiens]                       139   4e-33
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa...   138   9e-33
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]           135   6e-32
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   135   7e-32
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   135   7e-32
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor...   133   2e-31
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor...   133   2e-31
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]         132   4e-31
gi|225579152 insulin-like growth factor binding protein, acid la...   125   6e-29
gi|4826772 insulin-like growth factor binding protein, acid labi...   125   6e-29
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ...   122   4e-28
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]               121   1e-27
gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo s...   119   3e-27
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...   118   7e-27
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]            118   9e-27
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   117   1e-26
gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo...   115   5e-26
gi|88702793 slit-like 2 [Homo sapiens]                                115   5e-26
gi|4502403 biglycan preproprotein [Homo sapiens]                      113   2e-25
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...   111   9e-25
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...   111   9e-25
gi|13194201 reticulon 4 receptor precursor [Homo sapiens]             109   3e-24
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...   108   6e-24
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                108   7e-24
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo...   108   1e-23
gi|41350214 asporin [Homo sapiens]                                    107   2e-23

>gi|153251229 chondroadherin precursor [Homo sapiens]
          Length = 359

 Score =  727 bits (1876), Expect = 0.0
 Identities = 359/359 (100%), Positives = 359/359 (100%)

Query: 1   MVRPMLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQR 60
           MVRPMLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQR
Sbjct: 1   MVRPMLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQR 60

Query: 61  NNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFD 120
           NNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFD
Sbjct: 61  NNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFD 120

Query: 121 DLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSE 180
           DLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSE
Sbjct: 121 DLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSE 180

Query: 181 NALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQ 240
           NALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQ
Sbjct: 181 NALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQ 240

Query: 241 SFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETLALTNN 300
           SFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETLALTNN
Sbjct: 241 SFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETLALTNN 300

Query: 301 PWKCTCQLRGLRRWLEAKASRPDATCASPAKFKGQHIRDTDAFRSCKFPTKRSKKAGRH 359
           PWKCTCQLRGLRRWLEAKASRPDATCASPAKFKGQHIRDTDAFRSCKFPTKRSKKAGRH
Sbjct: 301 PWKCTCQLRGLRRWLEAKASRPDATCASPAKFKGQHIRDTDAFRSCKFPTKRSKKAGRH 359


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  255 bits (651), Expect = 5e-68
 Identities = 143/343 (41%), Positives = 203/343 (59%), Gaps = 5/343 (1%)

Query: 19  ALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANSFRAMPNL 77
           A+A CP+ C C  + +H  C+  GLQ +P+     T+LL+L+RN+FP +   +F  + +L
Sbjct: 392 AVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHL 451

Query: 78  VSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTE 137
           VSLHLQHC I E+ AGA  GL +LIYLYLS N +  L A A +    L YLYL+ N+  +
Sbjct: 452 VSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQ 511

Query: 138 LPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENL 197
           +P   L  L +LF L L +N +  L  G     + LRW+YLS N ++ +  GAL     L
Sbjct: 512 VPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPAREL 571

Query: 198 AKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLE 257
            K H+DRNQL   P+ AL  L  + EL+LS NPL+++ D AFQ  GR L+ L+L+++ LE
Sbjct: 572 EKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLE 631

Query: 258 KFSDGAFLGV-TTLKHVHLENNRLNQLPSNFPFDSLETLALTNNPWKCTCQLRGLRRWLE 316
           +   GAF G+   L+ +HL+ N+L  LP+      LE + L++NP+ C CQL  L RWL 
Sbjct: 632 QICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNPFHCDCQLLPLHRWLT 691

Query: 317 AKASRPDATCASPAKFKGQHIRDTDA-FRSCKFPTKRSKKAGR 358
               R  ATCA+P   +GQ ++   A F  C  P   ++KA R
Sbjct: 692 GLNLRVGATCATPPNARGQRVKAAAAVFEDC--PGWAARKAKR 732



 Score =  183 bits (464), Expect = 2e-46
 Identities = 126/345 (36%), Positives = 171/345 (49%), Gaps = 6/345 (1%)

Query: 1   MVRPMLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQ 59
           +V P+L+L L L      A   CPQ C C +  +HV C    L ++P  + E T+ L+LQ
Sbjct: 12  LVLPLLVLLL-LAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQ 70

Query: 60  RNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAF 119
            N   V+ A +F+ +P+L  L L+HC++  VA GAFRGL +L+ L L+ N +R L   A 
Sbjct: 71  GNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEAL 130

Query: 120 DDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLS 179
           D L  L  L L+ N + EL  G    L  L  L L +N +  L A AFQG   +RWL LS
Sbjct: 131 DGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLS 190

Query: 180 ENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAF 239
            NALS L P AL  +  L +  +  N+L + P   LS+ R +  L+L HNPL    +   
Sbjct: 191 HNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDG 250

Query: 240 QSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETLALTN 299
            +    L  L LD   L+     AF     L  + L  N+L+ LP       L  L L  
Sbjct: 251 LALPG-LRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQG 309

Query: 300 NPWKCTCQLRGLRRWLEAKASRPDATCASPAKFKGQHIRDTDAFR 344
           NP  C CQ R L  WL     R D  C  P + +G+ +   DA R
Sbjct: 310 NPLWCGCQARPLLEWLARARVRSDGACQGPRRLRGEAL---DALR 351


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score =  162 bits (411), Expect = 3e-40
 Identities = 116/389 (29%), Positives = 176/389 (45%), Gaps = 54/389 (13%)

Query: 2   VRPMLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQR 60
           +R  L+++  LL  L   +  C   C   +  Q + C  +GL  IPK   E T  L L  
Sbjct: 11  LRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQ-INCRNLGLSSIPKNFPESTVFLYLTG 69

Query: 61  NNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFD 120
           NN   +  +    + +LV+L+L +  I  V   AF  L+ L +L+L++N I+ L  G F 
Sbjct: 70  NNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFK 129

Query: 121 DLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSE 180
            L  L  LYL +N+V+ +PRG+ + LV++  L L  N++  L +G F G   LR L LS 
Sbjct: 130 GLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSN 189

Query: 181 NALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQ 240
           N +  +       +ENLA  ++  N L+  PS A   L+ +  L LSHNP+++I   AF+
Sbjct: 190 NNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFK 249

Query: 241 SFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF------------- 287
                LE L L N+ +   +   F G+  LKH+ L +N L  L S+              
Sbjct: 250 GLAN-LEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLD 308

Query: 288 --------------------------------------PFDSLETLALTNNPWKCTCQLR 309
                                                 P  SL  L   +NPW+C C+L 
Sbjct: 309 RNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLL 368

Query: 310 GLRRWLEAKASRPDATCASPAKFKGQHIR 338
           GLR WL + A   +  C +P   +G+ +R
Sbjct: 369 GLRDWLASSAITLNIYCQNPPSMRGRALR 397


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score =  154 bits (390), Expect = 9e-38
 Identities = 111/344 (32%), Positives = 166/344 (48%), Gaps = 35/344 (10%)

Query: 5   MLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNF 63
           +L L L ++AGL+ A   CP  C C +    VIC +  L+++P  +S  T+LLNL  N  
Sbjct: 30  LLALQLLVVAGLVRA-QTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQI 88

Query: 64  PVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLT 123
            ++  NSF+        HL+H +I                L LS N IR +  GAF+ L 
Sbjct: 89  QIIKVNSFK--------HLRHLEI----------------LQLSRNHIRTIEIGAFNGLA 124

Query: 124 ELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSE-NA 182
            L  L L  N++T +P G    L  L  L L NN I  + + AF     LR L L E   
Sbjct: 125 NLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKR 184

Query: 183 LSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSF 242
           LS +  GA + + NL   ++    L   P+  L+ L  ++EL LS N L +I   +FQ  
Sbjct: 185 LSYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGL 242

Query: 243 GRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNN 300
             +L+ LW+  + ++     AF  + +L  ++L +N L  LP +   P   LE + L +N
Sbjct: 243 -MHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301

Query: 301 PWKCTCQLRGLRRWLEAKASRPDATCA---SPAKFKGQHIRDTD 341
           PW C C +  L  W++  A    A CA   +P   KG++I + D
Sbjct: 302 PWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELD 345


>gi|12007646 nyctalopin precursor [Homo sapiens]
          Length = 481

 Score =  139 bits (350), Expect = 4e-33
 Identities = 116/379 (30%), Positives = 169/379 (44%), Gaps = 37/379 (9%)

Query: 3   RPMLLLSL-GLLAGLLPALA------ACPQNCHCHSDLQ--HVICDKVGLQKIP-KVSEK 52
           R ML+L L  ++ GL  A A      ACP  C C +  +   V CD+ GL ++P ++  +
Sbjct: 4   RGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCE 63

Query: 53  TKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHN-DI 111
              ++L RN    L   +F  +P+L  L L+H  +  +  GAF+GL +L  L L+HN D+
Sbjct: 64  AVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDL 123

Query: 112 RVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPL-----------------------VN 148
           R L A  F  L+ L  L L   ++  +P  LL+ L                        N
Sbjct: 124 RYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLAN 183

Query: 149 LFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLS 208
           L    L   +I  + + + QG + LR L L  N + ++  GA  D   L    ++ N L+
Sbjct: 184 LTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLA 243

Query: 209 SYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVT 268
             P+ A   LR +  L L  N L  +    F      LE L+LD  ++    +GAF  ++
Sbjct: 244 ELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAE-LELLYLDRNSIAFVEEGAFQNLS 302

Query: 269 TLKHVHLENNRLNQLP--SNFPFDSLETLALTNNPWKCTCQLRGLRRWLEAKASRPDATC 326
            L  +HL  NRL  L   +  P   L  L L  NPW C C+L  LR W+E      D  C
Sbjct: 303 GLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVPC 362

Query: 327 ASPAKFKGQHIRDTDAFRS 345
           ASP    G  +      RS
Sbjct: 363 ASPGSVAGLDLSQVTFGRS 381


>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
           sapiens]
          Length = 516

 Score =  138 bits (347), Expect = 9e-33
 Identities = 109/352 (30%), Positives = 165/352 (46%), Gaps = 12/352 (3%)

Query: 4   PML--LLSLGLLAGLLPALA-ACPQNCHCHSDLQHVICDKVGLQKIPKVSEKTKL-LNLQ 59
           PML  + ++ ++  +LPAL  ACP  C C   L +  CD  G   +P  ++K  L L+L+
Sbjct: 12  PMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFY--CDSQGFHSVPNATDKGSLGLSLR 69

Query: 60  RNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAF 119
            N+   L  + F +   L  LHL H QI  V   AF+GL +L  L LS N I  L    F
Sbjct: 70  HNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTF 129

Query: 120 DDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLS 179
             L  L  L L  N+++ L   L   L  L  L L +N +R +    F   + L +L LS
Sbjct: 130 TQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLS 189

Query: 180 ENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAF 239
            N L SL       +  L + H++ NQL+    A   +L  +  L L  N + ++     
Sbjct: 190 TNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGME 249

Query: 240 QSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLAL 297
            ++G  LE L L    ++      F  +  LK + ++NN+LN L S       SL T+ L
Sbjct: 250 WTWGT-LEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGL 308

Query: 298 TNNPWKCTCQLRGLRRWLEAKASRPDAT--CASPAKFKGQHIRD-TDAFRSC 346
           + N W+C+ ++  L  WL +   R + +  C SP   +G+ I D    F+ C
Sbjct: 309 SGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLC 360


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score =  135 bits (340), Expect = 6e-32
 Identities = 101/350 (28%), Positives = 164/350 (46%), Gaps = 39/350 (11%)

Query: 12  LLAGLLPALAACPQNC----HCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVL 66
           L A +  A +A PQNC     C +    V+C + GL ++P+ +   T+ LNL  NN  ++
Sbjct: 31  LCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMI 90

Query: 67  AANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELT 126
            A++FR + +L  L L    IR++  GAF GL  L  L L  N + V+ +GAF+ L++L 
Sbjct: 91  QADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLR 150

Query: 127 YLYLDHNKVTELPRGLLSPLVNLFILQLNN-NKIRELRAGAFQGAKDLRWLYLSENALSS 185
            L+L +N +  +P    + + +L  L L    K+  +  GAF+G  +L++L L    +  
Sbjct: 151 ELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIK- 209

Query: 186 LQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRY 245
                  D+ NL                  + L  +EEL++S N    I   +F      
Sbjct: 210 -------DMPNL------------------TPLVGLEELEMSGNHFPEIRPGSFHGLSS- 243

Query: 246 LETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNNPWK 303
           L+ LW+ N+ +      AF G+ +L  ++L +N L+ LP +   P   L  L L +NPW 
Sbjct: 244 LKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWN 303

Query: 304 CTCQLRGLRRWLEAKASRPDATCA---SPAKFKGQHIRDTD-AFRSCKFP 349
           C C +  L  WL          C    +P   +G+++ + D A   C  P
Sbjct: 304 CDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAP 353


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  135 bits (339), Expect = 7e-32
 Identities = 92/289 (31%), Positives = 135/289 (46%), Gaps = 9/289 (3%)

Query: 56  LNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLR 115
           LNL +N+   ++   F+ + NL  L L   ++ ++  G F GL  L  L L  N I +L 
Sbjct: 184 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 243

Query: 116 AGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRW 175
            G F +   L  LYL +N +++LP  +   L  L  L L  N ++EL  G F    +LR 
Sbjct: 244 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 303

Query: 176 LYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIP 235
           L+L +N +SSL      ++  L    + RNQ+S     A + L  + EL L  N L+ + 
Sbjct: 304 LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLD 363

Query: 236 DNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETL 295
            N F+     L+ + L N  L +     F  V  L  + L+NN+L  LP    FD L  L
Sbjct: 364 GNVFRMLAN-LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGI-FDHLGKL 421

Query: 296 A---LTNNPWKCTCQLRGLRRWLEAKASRPDA----TCASPAKFKGQHI 337
               L +NPW+C   +  LR WL     R        C SPA  +GQ +
Sbjct: 422 CELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSL 470


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  135 bits (339), Expect = 7e-32
 Identities = 92/289 (31%), Positives = 135/289 (46%), Gaps = 9/289 (3%)

Query: 56  LNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLR 115
           LNL +N+   ++   F+ + NL  L L   ++ ++  G F GL  L  L L  N I +L 
Sbjct: 178 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 237

Query: 116 AGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRW 175
            G F +   L  LYL +N +++LP  +   L  L  L L  N ++EL  G F    +LR 
Sbjct: 238 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 297

Query: 176 LYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIP 235
           L+L +N +SSL      ++  L    + RNQ+S     A + L  + EL L  N L+ + 
Sbjct: 298 LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLD 357

Query: 236 DNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETL 295
            N F+     L+ + L N  L +     F  V  L  + L+NN+L  LP    FD L  L
Sbjct: 358 GNVFRMLAN-LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGI-FDHLGKL 415

Query: 296 A---LTNNPWKCTCQLRGLRRWLEAKASRPDA----TCASPAKFKGQHI 337
               L +NPW+C   +  LR WL     R        C SPA  +GQ +
Sbjct: 416 CELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSL 464


>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
           [Homo sapiens]
          Length = 518

 Score =  133 bits (335), Expect = 2e-31
 Identities = 97/340 (28%), Positives = 162/340 (47%), Gaps = 8/340 (2%)

Query: 5   MLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNF 63
           ++LL   LL  L  A  ACP+NC C   +  V C+      IP+ +S  ++ L+L+ N+ 
Sbjct: 16  LVLLPTLLLVMLTGAQRACPKNCRCDGKI--VYCESHAFADIPENISGGSQGLSLRFNSI 73

Query: 64  PVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLT 123
             L +N F  +  L+ L+L H  I  V   AF+G+++L  L LS N I  L    F  + 
Sbjct: 74  QKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVP 133

Query: 124 ELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENAL 183
            L  L L +NK+  L       L  L IL L +N ++ +    FQ  ++L +L L  N L
Sbjct: 134 NLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 193

Query: 184 SSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFG 243
            SL   A   +  L + H++ NQ S    A   +L  +  + L  N ++SI      ++ 
Sbjct: 194 RSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWS 253

Query: 244 RYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNNP 301
             L  L L   +++    G F  +  L+ ++L++N+L  +       + SL ++ L+ N 
Sbjct: 254 S-LHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNM 312

Query: 302 WKCTCQLRGLRRWLEAKASRPDAT--CASPAKFKGQHIRD 339
           W+C+  +  L  WL+      ++T  CA P   +G+ + D
Sbjct: 313 WECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSD 352


>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
           [Homo sapiens]
          Length = 590

 Score =  133 bits (335), Expect = 2e-31
 Identities = 97/340 (28%), Positives = 162/340 (47%), Gaps = 8/340 (2%)

Query: 5   MLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNF 63
           ++LL   LL  L  A  ACP+NC C   +  V C+      IP+ +S  ++ L+L+ N+ 
Sbjct: 16  LVLLPTLLLVMLTGAQRACPKNCRCDGKI--VYCESHAFADIPENISGGSQGLSLRFNSI 73

Query: 64  PVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLT 123
             L +N F  +  L+ L+L H  I  V   AF+G+++L  L LS N I  L    F  + 
Sbjct: 74  QKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVP 133

Query: 124 ELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENAL 183
            L  L L +NK+  L       L  L IL L +N ++ +    FQ  ++L +L L  N L
Sbjct: 134 NLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 193

Query: 184 SSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFG 243
            SL   A   +  L + H++ NQ S    A   +L  +  + L  N ++SI      ++ 
Sbjct: 194 RSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWS 253

Query: 244 RYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNNP 301
             L  L L   +++    G F  +  L+ ++L++N+L  +       + SL ++ L+ N 
Sbjct: 254 S-LHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNM 312

Query: 302 WKCTCQLRGLRRWLEAKASRPDAT--CASPAKFKGQHIRD 339
           W+C+  +  L  WL+      ++T  CA P   +G+ + D
Sbjct: 313 WECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSD 352


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score =  132 bits (333), Expect = 4e-31
 Identities = 101/331 (30%), Positives = 149/331 (45%), Gaps = 34/331 (10%)

Query: 18  PALAACPQNCHCHSDLQHVICDKVGLQKIP-KVSEKTKLLNLQRNNFPVLAANSFRAMPN 76
           P   +CP  C C +    VIC +  L ++P  +   T+ LNLQ N   V+  ++F+    
Sbjct: 52  PPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFK---- 107

Query: 77  LVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVT 136
               HL+H +I                L LS N +R +  GAF+ L  L  L L  N++T
Sbjct: 108 ----HLRHLEI----------------LQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLT 147

Query: 137 ELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSE-NALSSLQPGALDDVE 195
            +P      L  L  L L NN I  + + AF     LR L L E   L  +   A + + 
Sbjct: 148 TVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLV 207

Query: 196 NLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTN 255
           NL   ++    L   P+  L+ L  +EEL+LS N L  I   +FQ     L  LWL +  
Sbjct: 208 NLRYLNLGMCNLKDIPN--LTALVRLEELELSGNRLDLIRPGSFQGLTS-LRKLWLMHAQ 264

Query: 256 LEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNNPWKCTCQLRGLRR 313
           +      AF  + +L+ ++L +N L  LP +   P   LE + L +NPW C C +  L  
Sbjct: 265 VATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSW 324

Query: 314 WLEAKASRPDATCA---SPAKFKGQHIRDTD 341
           WL+         CA   +PA  KG++I + D
Sbjct: 325 WLKETVPSNTTCCARCHAPAGLKGRYIGELD 355


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score =  125 bits (314), Expect = 6e-29
 Identities = 94/309 (30%), Positives = 138/309 (44%), Gaps = 28/309 (9%)

Query: 54  KLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRV 113
           ++L L  N    L   +F+ +  L  L L H +IR++A  +F GL QL  L L HN ++ 
Sbjct: 331 RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE 390

Query: 114 LRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDL 173
           ++AGAF  LT +  + L  N +  LP  +   L  L  L L  + +  +R   F G   L
Sbjct: 391 VKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGL 450

Query: 174 RWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKS 233
           R L+L +N L  ++  +L  +  L +  +  NQL+  P      L  +E L LS N L  
Sbjct: 451 RRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAE 510

Query: 234 IPDNAFQSFGRYLETLWLD--NTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDS 291
           +P +A    G      WLD  +  LE   +     +  L+++ L NN L       P   
Sbjct: 511 LPADA---LGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPP--G 565

Query: 292 LETLALTNNPWKCTCQLRGLR-----------RWLEAKASRPDA----------TCASPA 330
           LE L L  NPW C C L+ LR           R+++A     D           TCASP 
Sbjct: 566 LERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPP 625

Query: 331 KFKGQHIRD 339
           +  G  +RD
Sbjct: 626 EVVGLDLRD 634



 Score =  107 bits (266), Expect = 2e-23
 Identities = 75/229 (32%), Positives = 111/229 (48%), Gaps = 25/229 (10%)

Query: 56  LNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLR 115
           LNL  N+  VL   +FR + +L  L L   ++  +    F GL +L  L LS N +R ++
Sbjct: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272

Query: 116 AGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRW 175
           A  F  L  L  LYLD N +  +  G    L  L  L L++N++  L    F G   LR 
Sbjct: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 332

Query: 176 LYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIP 235
           L LS NA++SL+P    D                        L  +EEL+L HN ++ + 
Sbjct: 333 LRLSHNAIASLRPRTFKD------------------------LHFLEELQLGHNRIRQLA 368

Query: 236 DNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLP 284
           + +F+  G+ LE L LD+  L++   GAFLG+T +  ++L  N L  LP
Sbjct: 369 ERSFEGLGQ-LEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLP 416


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score =  125 bits (314), Expect = 6e-29
 Identities = 94/309 (30%), Positives = 138/309 (44%), Gaps = 28/309 (9%)

Query: 54  KLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRV 113
           ++L L  N    L   +F+ +  L  L L H +IR++A  +F GL QL  L L HN ++ 
Sbjct: 293 RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE 352

Query: 114 LRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDL 173
           ++AGAF  LT +  + L  N +  LP  +   L  L  L L  + +  +R   F G   L
Sbjct: 353 VKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGL 412

Query: 174 RWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKS 233
           R L+L +N L  ++  +L  +  L +  +  NQL+  P      L  +E L LS N L  
Sbjct: 413 RRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAE 472

Query: 234 IPDNAFQSFGRYLETLWLD--NTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDS 291
           +P +A    G      WLD  +  LE   +     +  L+++ L NN L       P   
Sbjct: 473 LPADA---LGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPP--G 527

Query: 292 LETLALTNNPWKCTCQLRGLR-----------RWLEAKASRPDA----------TCASPA 330
           LE L L  NPW C C L+ LR           R+++A     D           TCASP 
Sbjct: 528 LERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPP 587

Query: 331 KFKGQHIRD 339
           +  G  +RD
Sbjct: 588 EVVGLDLRD 596



 Score =  107 bits (266), Expect = 2e-23
 Identities = 75/229 (32%), Positives = 111/229 (48%), Gaps = 25/229 (10%)

Query: 56  LNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLR 115
           LNL  N+  VL   +FR + +L  L L   ++  +    F GL +L  L LS N +R ++
Sbjct: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234

Query: 116 AGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRW 175
           A  F  L  L  LYLD N +  +  G    L  L  L L++N++  L    F G   LR 
Sbjct: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294

Query: 176 LYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIP 235
           L LS NA++SL+P    D                        L  +EEL+L HN ++ + 
Sbjct: 295 LRLSHNAIASLRPRTFKD------------------------LHFLEELQLGHNRIRQLA 330

Query: 236 DNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLP 284
           + +F+  G+ LE L LD+  L++   GAFLG+T +  ++L  N L  LP
Sbjct: 331 ERSFEGLGQ-LEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLP 378


>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
           sapiens]
          Length = 581

 Score =  122 bits (307), Expect = 4e-28
 Identities = 95/334 (28%), Positives = 152/334 (45%), Gaps = 9/334 (2%)

Query: 12  LLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANS 70
           LL  L  A   CP+ C C   +  V C+   LQ+IP  +S     L+L+ N+   L  N 
Sbjct: 23  LLTMLSSAERGCPKGCRCEGKM--VYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQ 80

Query: 71  FRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYL 130
           F+ +  L  L+L H  I  +   AF G+++L  L LS N I       F  +T L  L L
Sbjct: 81  FKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDL 140

Query: 131 DHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGA 190
            +N++  L       L  L  L L +N +R +    FQ  ++L  L L  N + SL    
Sbjct: 141 SYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNV 200

Query: 191 LDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLW 250
              +  L + H++ NQ S    A   +L  ++ L L  N +  I      ++   L+ L 
Sbjct: 201 FAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSS-LQRLD 259

Query: 251 LDNTNLEKFSD-GAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNNPWKCTCQ 307
           L    +E FS    F  V  L+ ++L++N+L  +       + SL  ++L  N W+C+  
Sbjct: 260 LSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRN 319

Query: 308 LRGLRRWLEAKASRPDAT--CASPAKFKGQHIRD 339
           +  L  WL++     + T  CASP + +G ++ D
Sbjct: 320 ICSLVNWLKSFKGLRENTIICASPKELQGVNVID 353


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score =  121 bits (303), Expect = 1e-27
 Identities = 115/416 (27%), Positives = 165/416 (39%), Gaps = 106/416 (25%)

Query: 5   MLLLSLGLLAGLLPALA--ACPQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQRNN 62
           +LL+  G LA  LP LA   CP+ C C    QH++C   GL+ +PK S            
Sbjct: 9   LLLVVCGCLA--LPPLAEPVCPERCDCQHP-QHLLCTNRGLRVVPKTS------------ 53

Query: 63  FPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDL 122
                  S  +  ++++  L    I  + A  F  L QL  L L +N IR L    F+ L
Sbjct: 54  -------SLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKL 106

Query: 123 TELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENA 182
           + L  LYL +N +  L  G L+PL  L IL  N N+I  L  G+F+G + L  L L  NA
Sbjct: 107 SRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNA 166

Query: 183 LSSLQPGALDDVENLAKFHVDRNQL--------------------------SSYPSAALS 216
           L +L       + NL   H++ N++                          S   +A  +
Sbjct: 167 LGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFA 226

Query: 217 KLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLE 276
            LR +  L LS N L+ +    FQ   R L  L L    L   +  AF G+  L+ + LE
Sbjct: 227 PLRSLSSLILSANNLQHLGPRIFQHLPR-LGLLSLRGNQLTHLAPEAFWGLEALRELRLE 285

Query: 277 NNRLNQLPSNF--PFDSLETLALTNNP--------------------------------- 301
            NRL+QLP+    P  SLE L L+ N                                  
Sbjct: 286 GNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIF 345

Query: 302 ---------------WKCTCQLRGLRRWL-----EAKASRPDATCASPAKFKGQHI 337
                          W C C+LRGL+RW+     + +       C  P   +G+++
Sbjct: 346 AASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYL 401


>gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
           sapiens]
          Length = 522

 Score =  119 bits (299), Expect = 3e-27
 Identities = 101/374 (27%), Positives = 153/374 (40%), Gaps = 60/374 (16%)

Query: 5   MLLLSLGLLAGLLPAL-AACPQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQRNNF 63
           ++L  LG    +LPA  + CPQ C C   L +  C+ + L + P                
Sbjct: 20  VVLCLLGACFQMLPAAPSGCPQLCRCEGRLLY--CEALNLTEAP---------------- 61

Query: 64  PVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLT 123
                     +  L+ L L++  + E+ AG F GL QL +LYL HN I  ++  AF  L 
Sbjct: 62  --------HNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLR 113

Query: 124 ELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENAL 183
            +  L L  N++T+LP     P+ NL  + L+ NK++ L    F G + L  L++  NA+
Sbjct: 114 RVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAI 173

Query: 184 SSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFG 243
             +      D  +L    +  NQL S    + + L  + EL L HN L  +    F  F 
Sbjct: 174 QFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKV---NFAHFP 230

Query: 244 RY-------------------------LETLWLDNTNLEKFSDGAFLGVTTLKHVHLENN 278
           R                          LE + L    +E      F  V  L+ + L++N
Sbjct: 231 RLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSN 290

Query: 279 RLNQLPSNF--PFDSLETLALTNNPWKCTCQLRGLRRWLEAKASRPDAT--CASPAKFKG 334
           RL  +       + SL ++ L  N W C   +  L  WL     R D    CASP   +G
Sbjct: 291 RLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQG 350

Query: 335 QHIRD-TDAFRSCK 347
           + + D   AF  C+
Sbjct: 351 EDVLDAVYAFHLCE 364


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score =  118 bits (296), Expect = 7e-27
 Identities = 86/295 (29%), Positives = 139/295 (47%), Gaps = 7/295 (2%)

Query: 49  VSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSH 108
           +S     L L +N    L   +F+ +P L  L L   +IR +    F+GL  L  L L  
Sbjct: 186 LSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQR 244

Query: 109 NDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQ 168
           N+I  L  GAF  L+++  L+L++N + E+  G L  L  L  L L+NN I  +    + 
Sbjct: 245 NNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWS 304

Query: 169 GAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSH 228
             + L  L LS N L+ L   +L ++ +L+   +  N +S     A   LR +  L L H
Sbjct: 305 FCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDH 364

Query: 229 NPLKSIPDNAFQSFGRY--LETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLN--QLP 284
           N +    ++   +F     L  L L    ++  +  AF G+  L+H++L  N +   Q  
Sbjct: 365 NEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFD 424

Query: 285 SNFPFDSLETLALTNNPWKCTCQLRGLRRWLEAKASRP--DATCASPAKFKGQHI 337
           +     +L+ L ++++ + C CQL+ L  WL  +  +    ATCA P   KGQ I
Sbjct: 425 AFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSI 479



 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 86/307 (28%), Positives = 137/307 (44%), Gaps = 39/307 (12%)

Query: 4   PMLLLSLGLLAGLLPALAA------CPQNCHCHSDLQHVICDKVGLQKIP-KVSEKTKLL 56
           P LLL   LL  L P  AA      C   C C  D   + C   GL  +P  +   T+ L
Sbjct: 16  PCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGD--SLDCGGRGLAALPGDLPSWTRSL 73

Query: 57  NLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRA 116
           NL  N    +    F  +PNL  ++L + ++  V +                        
Sbjct: 74  NLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPS-----------------------L 110

Query: 117 GAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWL 176
           GA    + +  L+L HNK+  +    L   ++L +L L+ N I E+R   F     ++ L
Sbjct: 111 GAAS--SHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKEL 168

Query: 177 YLSENALSSLQPGALDDV-ENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIP 235
            L+ N + +L+ GA D +  +L    + +N+++  P  A  KL  + +L L+ N ++ I 
Sbjct: 169 NLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLIE 227

Query: 236 DNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSN--FPFDSLE 293
              FQ     LE L L   N+ K +DGAF G++ +  +HLE N L ++ S   +   +L 
Sbjct: 228 GLTFQGLNS-LEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALH 286

Query: 294 TLALTNN 300
            L L+NN
Sbjct: 287 QLHLSNN 293


>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
          Length = 620

 Score =  118 bits (295), Expect = 9e-27
 Identities = 103/390 (26%), Positives = 167/390 (42%), Gaps = 57/390 (14%)

Query: 3   RPMLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRN 61
           +P+LLL LG +  L  +   CP  C C +  + V+C +     +P+ +  +T+LL+L +N
Sbjct: 24  QPILLLVLGSV--LSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKN 81

Query: 62  NFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDD 121
               L  + F + P+L  L L    +  V  GAF  L  L  L L  N ++++  G F  
Sbjct: 82  RIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTG 141

Query: 122 LTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSEN 181
           L+ LT L +  NK+  L   +   L NL  L++ +N +  +   AF G   L  L L + 
Sbjct: 142 LSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKC 201

Query: 182 ALSSLQPGALDDVENLAKF---HVDRNQLSSYPSAALSKLRVVEE--------------- 223
            L+S+   AL  +  L      H++ N +  Y    L +L+V+E                
Sbjct: 202 NLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLY 261

Query: 224 ------------------------------LKLSHNPLKSIPDNAFQSFGRYLETLWLDN 253
                                         L LS+NP+ +I  +      R L+ + L  
Sbjct: 262 GLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLR-LQEIQLVG 320

Query: 254 TNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNNPWKCTCQLRGL 311
             L      AF G+  L+ +++  N+L  L  +      +LETL L +NP  C C+L  +
Sbjct: 321 GQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWV 380

Query: 312 --RRWLEAKASRPDATCASPAKFKGQHIRD 339
             RRW     +R   TCA+P   +G+  +D
Sbjct: 381 FRRRW-RLNFNRQQPTCATPEFVQGKEFKD 409


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  117 bits (294), Expect = 1e-26
 Identities = 116/430 (26%), Positives = 156/430 (36%), Gaps = 104/430 (24%)

Query: 7   LLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIP-KVSEKTKLLNLQRNNFPV 65
           LL   LL    PA   CP  C C   +Q V C    L  +P  +   TK +     +F  
Sbjct: 7   LLWTSLLLLARPA-QPCPMGCDCF--VQEVFCSDEELATVPLDIPPYTKNIIFVETSFTT 63

Query: 66  LAANSFRAMPNL---VSLHLQHCQIREVAAGA---------------------FRGLKQL 101
           L   +F + PNL   V L+ Q CQ R  A G                      F  L  L
Sbjct: 64  LETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSL 123

Query: 102 IYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRE 161
             L L+ N +  L  G F  L  L  L+L  N++  LPR L  PL +L  L L  N + +
Sbjct: 124 GKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQ 183

Query: 162 LRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVV 221
           L    F     L+ L LS NALS L  G    + +L +  +D N +S  P    S+L  +
Sbjct: 184 LPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCL 243

Query: 222 EELKLSHNPLKSIPDNAFQSFGR--YLETLW---------------------LDNTNLEK 258
           E L L  N +  +P + F S G   +L   W                     L +  LE 
Sbjct: 244 ERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLET 303

Query: 259 FSDGAFLGVTTLKHVHLENNRLNQLPSNFPFD---------------------------- 290
            ++G F  ++ L+ + L  N +  LP+    D                            
Sbjct: 304 VAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKL 363

Query: 291 ----------------------SLETLALTNNPWKCTCQLRGLRRWLEAKASR---PDAT 325
                                 +L  LAL  NPW+C C L  L  WL+    R       
Sbjct: 364 ELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTY 423

Query: 326 CASPAKFKGQ 335
           CA PA  KGQ
Sbjct: 424 CAGPAYLKGQ 433


>gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo
           sapiens]
          Length = 754

 Score =  115 bits (289), Expect = 5e-26
 Identities = 79/280 (28%), Positives = 126/280 (45%), Gaps = 27/280 (9%)

Query: 24  PQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQ 83
           PQ C C      + C    L+ +P +S    LL+L++N    L    F     L  + LQ
Sbjct: 112 PQCCDCKET--ELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQ 169

Query: 84  HCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLL 143
           H  IR ++  AF GL  L  LYL+HN I  LR G F DL +LT+L LD N +T + + L 
Sbjct: 170 HNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLF 229

Query: 144 SPLVNLFILQLNN------------------------NKIRELRAGAFQGAKDLRWLYLS 179
           + L +LF L + N                        N+I+ L    F     L  L+L 
Sbjct: 230 TGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLP 289

Query: 180 ENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAF 239
            N +  +       ++NL +  +  N ++         L+++++L LS NPL  +  N F
Sbjct: 290 RNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQF 349

Query: 240 QSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNR 279
           +S  + L++L L+   +   +   F  +  L H++ +N R
Sbjct: 350 ESL-KQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFR 388



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 39/155 (25%), Positives = 62/155 (40%)

Query: 56  LNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLR 115
           L++  N    L       MP L  + L+  +I+ +    F     L  L+L  N I  + 
Sbjct: 238 LSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVP 297

Query: 116 AGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRW 175
              F  L  L  L L  N +TEL   L   L  L  L L++N +  L    F+  K L+ 
Sbjct: 298 EKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQS 357

Query: 176 LYLSENALSSLQPGALDDVENLAKFHVDRNQLSSY 210
           L L    + ++       ++NL+  +    +  SY
Sbjct: 358 LDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSY 392



 Score = 35.4 bits (80), Expect = 0.080
 Identities = 28/109 (25%), Positives = 47/109 (43%), Gaps = 1/109 (0%)

Query: 176 LYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIP 235
           L L +N + SL          L K  +  N +      A   L  ++ L L+HN + ++ 
Sbjct: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201

Query: 236 DNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLP 284
              F+   + L  L LD+  + + S   F G+ +L  + + NN L  LP
Sbjct: 202 PGIFKDLHQ-LTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALP 249


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score =  115 bits (289), Expect = 5e-26
 Identities = 102/346 (29%), Positives = 144/346 (41%), Gaps = 13/346 (3%)

Query: 3   RPMLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRN 61
           R  LLL L LL  L P +  CP  C C S  Q V C       +P+ V   T  L +  N
Sbjct: 4   RVPLLLPLLLLLALGPGVQGCPSGCQC-SQPQTVFCTARQGTTVPRDVPPDTVGLYVFEN 62

Query: 62  NFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDD 121
              +L A SF  +P L  L L   QI  + +G F+ L  L  L L+ N +  +    F  
Sbjct: 63  GITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRG 122

Query: 122 LTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSEN 181
           L  L  LYL  N++  +  G    L  L  L+L +N   ELRA        L  L LS N
Sbjct: 123 LRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDN---ELRALPPLRLPRLLLLDLSHN 179

Query: 182 ALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQS 241
           +L +L+PG L D  N+    +    L        S+LR + +L +S N L+ +P    + 
Sbjct: 180 SLLALEPGIL-DTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPP-VIRG 237

Query: 242 FGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFP--FDSLETLALTN 299
                      NT + +       G+  L+ + + N  L  LP +    F  L  LA   
Sbjct: 238 LRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAAR 297

Query: 300 NPWKCTCQLRGLRRWLEAK----ASRPDATCASPAKFKGQHIRDTD 341
           NP+ C C L     W+       AS  +  C  P K  G+ + + D
Sbjct: 298 NPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELD 343


>gi|4502403 biglycan preproprotein [Homo sapiens]
          Length = 368

 Score =  113 bits (283), Expect = 2e-25
 Identities = 82/271 (30%), Positives = 132/271 (48%), Gaps = 37/271 (13%)

Query: 21  AACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANSFRAMPNLVS 79
           A CP  CHCH  L+ V C  +GL+ +PK +S  T LL+LQ N+                 
Sbjct: 61  AMCPFGCHCH--LRVVQCSDLGLKSVPKEISPDTTLLDLQNND----------------- 101

Query: 80  LHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELP 139
                  I E+    F+GL+ L  L L +N I  +   AF  L +L  LY+  N + E+P
Sbjct: 102 -------ISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIP 154

Query: 140 RGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENAL--SSLQPGALDDVENL 197
             L S LV    L++++N+IR++  G F G +++  + +  N L  S  +PGA D ++ L
Sbjct: 155 PNLPSSLVE---LRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLK-L 210

Query: 198 AKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLE 257
               +   +L+  P      L    EL L HN +++I       + + L  L L +  + 
Sbjct: 211 NYLRISEAKLTGIPKDLPETL---NELHLDHNKIQAIELEDLLRYSK-LYRLGLGHNQIR 266

Query: 258 KFSDGAFLGVTTLKHVHLENNRLNQLPSNFP 288
              +G+   + TL+ +HL+NN+L ++PS  P
Sbjct: 267 MIENGSLSFLPTLRELHLDNNKLARVPSGLP 297



 Score = 33.1 bits (74), Expect = 0.40
 Identities = 21/77 (27%), Positives = 39/77 (50%), Gaps = 2/77 (2%)

Query: 224 LKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQL 283
           L L +N +  +  + F+   ++L  L L N  + K  + AF  +  L+ +++  N L ++
Sbjct: 95  LDLQNNDISELRKDDFKGL-QHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEI 153

Query: 284 PSNFPFDSLETLALTNN 300
           P N P  SL  L + +N
Sbjct: 154 PPNLP-SSLVELRIHDN 169


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score =  111 bits (278), Expect = 9e-25
 Identities = 87/290 (30%), Positives = 134/290 (46%), Gaps = 9/290 (3%)

Query: 55  LLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVL 114
           +L L RN    +    F+ +P L  L L   +I+ V    F+GL  L  L +  N +  L
Sbjct: 196 VLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 254

Query: 115 RAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLR 174
             GAF  L+ +  L LDHN +TE+ +G L  L+ L  L L+ N I  +   A++  + L 
Sbjct: 255 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLS 314

Query: 175 WLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLK-S 233
            L L+ N LS L   +   +  L   H+  N++S     A   L  ++ L L +N +  +
Sbjct: 315 ELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWT 374

Query: 234 IPD--NAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSN--FPF 289
           I D   AF    + L  L L    +   +  AF G+  L+H+ L +N +  L  N     
Sbjct: 375 IEDMNGAFSGLDK-LRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQM 433

Query: 290 DSLETLALTNNPWKCTCQLRGLRRWLEAK--ASRPDATCASPAKFKGQHI 337
             L+ L L  +   C CQL+ L +W+      S  +A+CA P   KG+ I
Sbjct: 434 KKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 483



 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 75/283 (26%), Positives = 141/283 (49%), Gaps = 37/283 (13%)

Query: 23  CPQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVS-LH 81
           CP  C C  DL  + C +  L ++P+                         +P+ V+ L 
Sbjct: 47  CPTTCRCLGDL--LDCSRKRLARLPE------------------------PLPSWVARLD 80

Query: 82  LQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVL-RAGAFDDLTELTYLYLDHNKVTELPR 140
           L H ++  + A +   L+ L  + L++N++  +   G       +T L L  N++ E+  
Sbjct: 81  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEILP 138

Query: 141 GLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVEN-LAK 199
             L    +L  L L++N I EL+  AF  A  L++LYL+ N ++S++PG  D++ N L  
Sbjct: 139 EHLKEFQSLETLDLSSNNISELQT-AFP-ALQLKYLYLNSNRVTSMEPGYFDNLANTLLV 196

Query: 200 FHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKF 259
             ++RN++S+ P   + KL  ++ L+L+ N +K++    FQ  G  L++L +    + K 
Sbjct: 197 LKLNRNRISAIP-PKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA-LKSLKMQRNGVTKL 254

Query: 260 SDGAFLGVTTLKHVHLENNRLNQLPSNFPFD--SLETLALTNN 300
            DGAF G++ ++ + L++N L ++   + +    L+ L L+ N
Sbjct: 255 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQN 297


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score =  111 bits (278), Expect = 9e-25
 Identities = 87/290 (30%), Positives = 134/290 (46%), Gaps = 9/290 (3%)

Query: 55  LLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVL 114
           +L L RN    +    F+ +P L  L L   +I+ V    F+GL  L  L +  N +  L
Sbjct: 136 VLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 194

Query: 115 RAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLR 174
             GAF  L+ +  L LDHN +TE+ +G L  L+ L  L L+ N I  +   A++  + L 
Sbjct: 195 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLS 254

Query: 175 WLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLK-S 233
            L L+ N LS L   +   +  L   H+  N++S     A   L  ++ L L +N +  +
Sbjct: 255 ELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWT 314

Query: 234 IPD--NAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSN--FPF 289
           I D   AF    + L  L L    +   +  AF G+  L+H+ L +N +  L  N     
Sbjct: 315 IEDMNGAFSGLDK-LRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQM 373

Query: 290 DSLETLALTNNPWKCTCQLRGLRRWLEAK--ASRPDATCASPAKFKGQHI 337
             L+ L L  +   C CQL+ L +W+      S  +A+CA P   KG+ I
Sbjct: 374 KKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 423



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 63/223 (28%), Positives = 121/223 (54%), Gaps = 10/223 (4%)

Query: 82  LQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVL-RAGAFDDLTELTYLYLDHNKVTELPR 140
           L H ++  + A +   L+ L  + L++N++  +   G       +T L L  N++ E+  
Sbjct: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEILP 78

Query: 141 GLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVEN-LAK 199
             L    +L  L L++N I EL+  AF  A  L++LYL+ N ++S++PG  D++ N L  
Sbjct: 79  EHLKEFQSLETLDLSSNNISELQT-AFP-ALQLKYLYLNSNRVTSMEPGYFDNLANTLLV 136

Query: 200 FHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKF 259
             ++RN++S+ P   + KL  ++ L+L+ N +K++    FQ  G  L++L +    + K 
Sbjct: 137 LKLNRNRISAIP-PKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA-LKSLKMQRNGVTKL 194

Query: 260 SDGAFLGVTTLKHVHLENNRLNQLPSNFPFD--SLETLALTNN 300
            DGAF G++ ++ + L++N L ++   + +    L+ L L+ N
Sbjct: 195 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQN 237



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 27/106 (25%), Positives = 54/106 (50%), Gaps = 7/106 (6%)

Query: 200 FHVDR-----NQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNT 254
           FH+ R     N+LS   ++++S L+ + E+KL++N L++IP+         +  L L   
Sbjct: 14  FHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPN--LGPVSANITLLSLAGN 71

Query: 255 NLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETLALTNN 300
            + +          +L+ + L +N +++L + FP   L+ L L +N
Sbjct: 72  RIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSN 117


>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score =  109 bits (273), Expect = 3e-24
 Identities = 92/322 (28%), Positives = 137/322 (42%), Gaps = 51/322 (15%)

Query: 21  AACPQNCHCHSDLQHVI-CDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANSFRAMPNLV 78
           A CP  C C+++ +    C + GLQ +P  +   ++ + L  N    + A SFRA  NL 
Sbjct: 25  APCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLT 84

Query: 79  SLHLQHCQIREVAAGAFRGLKQLIYLYLSHN-DIRVLRAGAFDDLTELTYLYLDHNKVTE 137
            L L    +  + A AF GL  L  L LS N  +R +    F  L  L  L+LD   + E
Sbjct: 85  ILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQE 144

Query: 138 LPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENL 197
           L  GL                        F+G   L++LYL +NAL +L      D+ NL
Sbjct: 145 LGPGL------------------------FRGLAALQYLYLQDNALQALPDDTFRDLGNL 180

Query: 198 AKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLE 257
               +  N++SS P  A   L  ++ L L  N +  +  +AF+  GR L TL+L   NL 
Sbjct: 181 THLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGR-LMTLYLFANNLS 239

Query: 258 KFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETLALTNNPWKCTCQLRGLRRWLEA 317
                A                        P  +L+ L L +NPW C C+ R L  WL+ 
Sbjct: 240 ALPTEALA----------------------PLRALQYLRLNDNPWVCDCRARPLWAWLQK 277

Query: 318 -KASRPDATCASPAKFKGQHIR 338
            + S  +  C+ P +  G+ ++
Sbjct: 278 FRGSSSEVPCSLPQRLAGRDLK 299


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score =  108 bits (271), Expect = 6e-24
 Identities = 111/413 (26%), Positives = 167/413 (40%), Gaps = 62/413 (15%)

Query: 5   MLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNF 63
           +L L L LL    P    CP  C C    + V C +  L  +P  +  +T+LL L RN  
Sbjct: 7   VLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRI 66

Query: 64  PVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQL---------------------- 101
             L      A+P L  L L    I  V  GAF  L +L                      
Sbjct: 67  RCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLD 126

Query: 102 --IYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKI 159
               L LS N + +L    F DL  L  L +  N +  + R   + L+ L  L L    +
Sbjct: 127 NLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNL 186

Query: 160 RELRAGAFQGAKDLRWLYLSENALSSLQ-------PG----------ALDDVE------- 195
             L   +    + L  L L   A++SL+       PG           L++V        
Sbjct: 187 TALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGL 246

Query: 196 NLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTN 255
           NL    V    +++ P+AAL     +  L LSHNP+ ++P  +F+   R L  L L    
Sbjct: 247 NLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVR-LRELHLAGAL 305

Query: 256 LEKFSDGAFLGVTTLKHVHLENNRLNQLPSN--FPFDSLETLALTNNPWKCTCQLRGL-- 311
           L      AFLG+  ++ ++L NN L+ L  +     ++LETL +  NP  C C+L  +  
Sbjct: 306 LAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQ 365

Query: 312 -RRWLEAKASRPDATCASPAKFKGQHIRDTD-----AFRSCKFPTKRSKKAGR 358
            R+ L      P   CA+PA+ +G  +R+        +  C+ P  R ++  R
Sbjct: 366 RRKTLNFDGRLP--ACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQR 416


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score =  108 bits (270), Expect = 7e-24
 Identities = 100/342 (29%), Positives = 142/342 (41%), Gaps = 59/342 (17%)

Query: 12  LLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIP-KVSEKTKLLNLQRNNFPVLAANS 70
           +L  L  A  +CP  C C+S    V C       +P  +   T+ L LQ N    L   +
Sbjct: 20  MLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGT 79

Query: 71  FRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHN-DIRVLRAGAFDDLTELTYLY 129
           F +  NL++L L    +  +  G FR L+ L  L L  N  +R L    F  L  L  L+
Sbjct: 80  FGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLH 137

Query: 130 LDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPG 189
           L   +++ LP  +                        F+G   L++LYL EN+L  LQ  
Sbjct: 138 LYRCQLSSLPGNI------------------------FRGLVSLQYLYLQENSLLHLQDD 173

Query: 190 ALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETL 249
              D+ NL+                         L L  N L+ + ++ F+  G  L+ L
Sbjct: 174 LFADLANLS------------------------HLFLHGNRLRLLTEHVFRGLGS-LDRL 208

Query: 250 WLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFD--SLETLALTNNPWKCTCQ 307
            L    L+     AF G++ L  ++L NN L  LP     D  SLE L L  NPW C C+
Sbjct: 209 LLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCR 268

Query: 308 LRGLRRWLE-AKASRPDATCASPAKFKGQHIRDTDAFRSCKF 348
            R L  W + A+ S  D TCA+P + +G   RD  A R   F
Sbjct: 269 ARPLWAWFQRARVSSSDVTCATPPERQG---RDLRALREADF 307


>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
           sapiens]
          Length = 606

 Score =  108 bits (269), Expect = 1e-23
 Identities = 104/406 (25%), Positives = 159/406 (39%), Gaps = 60/406 (14%)

Query: 8   LSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVL 66
           L L ++   + +   CP  C C +  + V C +  L  IP+ +  +TK+L+L +N    +
Sbjct: 13  LGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSV 72

Query: 67  AANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELT 126
               F + P L  + L    I  V  GAF  L  L  L L  N ++++  G F  L+ LT
Sbjct: 73  NPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLT 132

Query: 127 YLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSL 186
            L +  NK+  L   +   L NL  L++ +N +  +   AF G   L  L L +  L+++
Sbjct: 133 KLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAV 192

Query: 187 QPGALDDVENLAKFH--------------------------------------------- 201
              AL  + +L   H                                             
Sbjct: 193 PTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLT 252

Query: 202 ---VDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEK 258
              V    LS+ P  A   L  +  L LS+NP+ +I    F    R L+ L +    L  
Sbjct: 253 SLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIR-LQELHIVGAQLRT 311

Query: 259 FSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDS---LETLALTNNPWKCTCQLRG-LRRW 314
               +F G+  L+ +++  N L  L  N  F S   LE L++ NNP  C C+L   L+R 
Sbjct: 312 IEPHSFQGLRFLRVLNVSQNLLETLEENV-FSSPRALEVLSINNNPLACDCRLLWILQRQ 370

Query: 315 LEAKASRPDATCASP-----AKFKGQHIRDTDAFRSCKFPTKRSKK 355
              +       CA P       FK  H      + +CK P  R KK
Sbjct: 371 PTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKK 416


>gi|41350214 asporin [Homo sapiens]
          Length = 380

 Score =  107 bits (267), Expect = 2e-23
 Identities = 73/269 (27%), Positives = 130/269 (48%), Gaps = 37/269 (13%)

Query: 23  CPQNCHCHSDLQHVICDKVGLQKIP-KVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLH 81
           CP  C C+S + H  C  +GL  +P  +   T++L+LQ N                    
Sbjct: 75  CPFGCQCYSRVVH--CSDLGLTSVPTNIPFDTRMLDLQNN-------------------- 112

Query: 82  LQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRG 141
               +I+E+    F+GL  L  L L++N +  +   AF    +L  LYL HN+++E+P  
Sbjct: 113 ----KIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLN 168

Query: 142 LLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENAL--SSLQPGALDDVENLAK 199
           L   L     L+++ NK+++++   F+G   L  L +S N L  + ++PGA + V  +  
Sbjct: 169 LPKSLAE---LRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGV-TVFH 224

Query: 200 FHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKF 259
             +   +L+S P      L    EL L +N + ++    F+ + + L+ L L N  +   
Sbjct: 225 IRIAEAKLTSVPKGLPPTLL---ELHLDYNKISTVELEDFKRY-KELQRLGLGNNKITDI 280

Query: 260 SDGAFLGVTTLKHVHLENNRLNQLPSNFP 288
            +G+   +  ++ +HLENN+L ++PS  P
Sbjct: 281 ENGSLANIPRVREIHLENNKLKKIPSGLP 309


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,006,937
Number of Sequences: 37866
Number of extensions: 545685
Number of successful extensions: 3972
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 188
Number of HSP's successfully gapped in prelim test: 74
Number of HSP's that attempted gapping in prelim test: 1250
Number of HSP's gapped (non-prelim): 955
length of query: 359
length of database: 18,247,518
effective HSP length: 103
effective length of query: 256
effective length of database: 14,347,320
effective search space: 3672913920
effective search space used: 3672913920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.