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Search of human proteins with 151101151
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|151101151 coiled-coil domain containing 2 isoform b [Homo
sapiens]
(372 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|151101151 coiled-coil domain containing 2 isoform b [Homo sap... 728 0.0
gi|151101140 coiled-coil domain containing 2 isoform a [Homo sap... 688 0.0
gi|151105223 coiled-coil domain containing 2 isoform a [Homo sap... 688 0.0
gi|151105229 coiled-coil domain containing 2 isoform a [Homo sap... 688 0.0
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 71 2e-12
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 70 3e-12
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 70 3e-12
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 70 3e-12
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 70 3e-12
gi|71061468 centromere protein E [Homo sapiens] 70 3e-12
gi|38044112 restin isoform b [Homo sapiens] 66 6e-11
gi|4506751 restin isoform a [Homo sapiens] 66 6e-11
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 64 3e-10
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 64 3e-10
gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens] 62 8e-10
gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 ... 62 1e-09
gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 ... 62 1e-09
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 61 1e-09
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 61 1e-09
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 61 2e-09
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 60 4e-09
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 60 4e-09
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 60 4e-09
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 60 4e-09
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 59 7e-09
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 59 9e-09
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 58 1e-08
gi|55770834 centromere protein F [Homo sapiens] 58 1e-08
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 58 1e-08
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 58 2e-08
>gi|151101151 coiled-coil domain containing 2 isoform b [Homo
sapiens]
Length = 372
Score = 728 bits (1878), Expect = 0.0
Identities = 372/372 (100%), Positives = 372/372 (100%)
Query: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV
Sbjct: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
Query: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE
Sbjct: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
Query: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
Sbjct: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
Query: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL
Sbjct: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
Query: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS
Sbjct: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
Query: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKI 360
PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKI
Sbjct: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKI 360
Query: 361 LEKNTGSFKKQV 372
LEKNTGSFKKQV
Sbjct: 361 LEKNTGSFKKQV 372
>gi|151101140 coiled-coil domain containing 2 isoform a [Homo
sapiens]
Length = 600
Score = 688 bits (1775), Expect = 0.0
Identities = 355/363 (97%), Positives = 357/363 (98%)
Query: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV
Sbjct: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
Query: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE
Sbjct: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
Query: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
Sbjct: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
Query: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL
Sbjct: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
Query: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS
Sbjct: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
Query: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKI 360
PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ N +K
Sbjct: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE 360
Query: 361 LEK 363
L+K
Sbjct: 361 LKK 363
Score = 54.7 bits (130), Expect = 1e-07
Identities = 62/289 (21%), Positives = 126/289 (43%), Gaps = 40/289 (13%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSV-YLSYEKRAETLAVEIKELQGQLADYNMLVDK 159
+RS E+ E I+ + EN V YL + E L E+ LQ QL NM +
Sbjct: 201 IRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKES 260
Query: 160 L-----NTNTEMEEVMNDYNMLKAQNDR-----ETQSLDVIFTERQAKEKQIRSVEEEI- 208
L ++ + E V+ + + ++ R E +S+ ER+ KQI+ +EI
Sbjct: 261 LEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIA 320
Query: 209 EQEKQATDDIIKNMSFENQV----------------KYLEMKTTNEKLLQELDTLQQQLD 252
E+Q TD K F ++ KY E+K E + ++T ++ +
Sbjct: 321 SMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKN 380
Query: 253 SQNMKKESLEAEIAH---------SQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPME 303
+ +K +EA I ++++Q + + +++L ++ + E + S +
Sbjct: 381 QELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQ 440
Query: 304 EREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQD 352
+++++ D Q++ +E ++T+ + + +I+Q+ DLE + D
Sbjct: 441 NLTSDIQRLQLDLQKMELLESKMTEEQHSLK---SKIKQMTTDLEIYND 486
>gi|151105223 coiled-coil domain containing 2 isoform a [Homo
sapiens]
Length = 600
Score = 688 bits (1775), Expect = 0.0
Identities = 355/363 (97%), Positives = 357/363 (98%)
Query: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV
Sbjct: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
Query: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE
Sbjct: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
Query: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
Sbjct: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
Query: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL
Sbjct: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
Query: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS
Sbjct: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
Query: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKI 360
PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ N +K
Sbjct: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE 360
Query: 361 LEK 363
L+K
Sbjct: 361 LKK 363
Score = 54.7 bits (130), Expect = 1e-07
Identities = 62/289 (21%), Positives = 126/289 (43%), Gaps = 40/289 (13%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSV-YLSYEKRAETLAVEIKELQGQLADYNMLVDK 159
+RS E+ E I+ + EN V YL + E L E+ LQ QL NM +
Sbjct: 201 IRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKES 260
Query: 160 L-----NTNTEMEEVMNDYNMLKAQNDR-----ETQSLDVIFTERQAKEKQIRSVEEEI- 208
L ++ + E V+ + + ++ R E +S+ ER+ KQI+ +EI
Sbjct: 261 LEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIA 320
Query: 209 EQEKQATDDIIKNMSFENQV----------------KYLEMKTTNEKLLQELDTLQQQLD 252
E+Q TD K F ++ KY E+K E + ++T ++ +
Sbjct: 321 SMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKN 380
Query: 253 SQNMKKESLEAEIAH---------SQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPME 303
+ +K +EA I ++++Q + + +++L ++ + E + S +
Sbjct: 381 QELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQ 440
Query: 304 EREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQD 352
+++++ D Q++ +E ++T+ + + +I+Q+ DLE + D
Sbjct: 441 NLTSDIQRLQLDLQKMELLESKMTEEQHSLK---SKIKQMTTDLEIYND 486
>gi|151105229 coiled-coil domain containing 2 isoform a [Homo
sapiens]
Length = 600
Score = 688 bits (1775), Expect = 0.0
Identities = 355/363 (97%), Positives = 357/363 (98%)
Query: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV
Sbjct: 1 MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGV 60
Query: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE
Sbjct: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
Query: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN
Sbjct: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN 180
Query: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL
Sbjct: 181 DRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKL 240
Query: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS
Sbjct: 241 LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
Query: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKI 360
PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ N +K
Sbjct: 301 PMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKE 360
Query: 361 LEK 363
L+K
Sbjct: 361 LKK 363
Score = 54.7 bits (130), Expect = 1e-07
Identities = 62/289 (21%), Positives = 126/289 (43%), Gaps = 40/289 (13%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSV-YLSYEKRAETLAVEIKELQGQLADYNMLVDK 159
+RS E+ E I+ + EN V YL + E L E+ LQ QL NM +
Sbjct: 201 IRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKES 260
Query: 160 L-----NTNTEMEEVMNDYNMLKAQNDR-----ETQSLDVIFTERQAKEKQIRSVEEEI- 208
L ++ + E V+ + + ++ R E +S+ ER+ KQI+ +EI
Sbjct: 261 LEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIA 320
Query: 209 EQEKQATDDIIKNMSFENQV----------------KYLEMKTTNEKLLQELDTLQQQLD 252
E+Q TD K F ++ KY E+K E + ++T ++ +
Sbjct: 321 SMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKN 380
Query: 253 SQNMKKESLEAEIAH---------SQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPME 303
+ +K +EA I ++++Q + + +++L ++ + E + S +
Sbjct: 381 QELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQ 440
Query: 304 EREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQD 352
+++++ D Q++ +E ++T+ + + +I+Q+ DLE + D
Sbjct: 441 NLTSDIQRLQLDLQKMELLESKMTEEQHSLK---SKIKQMTTDLEIYND 486
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 70.9 bits (172), Expect = 2e-12
Identities = 64/283 (22%), Positives = 135/283 (47%), Gaps = 35/283 (12%)
Query: 107 ELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVD-----KLN 161
EL + +KLQ ++ +++ EK+ A + L+ QL D L+ KLN
Sbjct: 1277 ELAEKASKLQNELD---NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN 1333
Query: 162 TNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKN 221
++ + ++ + N L+ Q + E ++ R+ EKQ+ +++ ++ K+ DD +
Sbjct: 1334 LSSRIRQLEEEKNSLQEQQEEEEEA-------RKNLEKQVLALQSQLADTKKKVDDDLGT 1386
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLL---H 278
+ + K +KLL++ + L Q+L+ + + + LE Q + + + + H
Sbjct: 1387 IESLEEAK--------KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH 1438
Query: 279 EK-----LYELESHRDQMIAEDKSIGSPM-EEREKLLKQIKDDNQEIASMERQLTDTKEK 332
++ L + + DQ++AE+KSI + EER++ + ++ + S+ R L + E
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 333 INQFIEEIRQLDMDLEE---HQDPTNYGWKILEKNTGSFKKQV 372
+F + +QL D+E+ +D LEK+ + ++QV
Sbjct: 1499 KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV 1541
Score = 58.2 bits (139), Expect = 1e-08
Identities = 61/279 (21%), Positives = 118/279 (42%), Gaps = 19/279 (6%)
Query: 74 QQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYE 133
Q+ K ++Q D S L L++++ + T + Q+ + ++ L
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELED-TLDTTAAQQELRTKREQEVAELK-- 1180
Query: 134 KRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTE 193
+ L E K + Q+ D M E+ E + KA ++ Q L+ E
Sbjct: 1181 ---KALEEETKNHEAQIQD--MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235
Query: 194 RQAKEKQIRSVEEEIEQEKQATDDIIKNMSF---ENQVKYLEMKTTNEKLLQELDTLQQQ 250
+ K ++ V+ E E +++ D ++ + E +E+ KL ELD +
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Query: 251 LDSQNMK--KESLEAEIAHSQVKQEAVLLHEKLYE---LESHRDQMIAEDKSIGSPMEER 305
L+ K K + +A SQ++ LL E+ + L S Q+ E S+ EE
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLD 344
E+ K ++ +++ +++ QL DTK+K++ + I L+
Sbjct: 1356 EEARKNLE---KQVLALQSQLADTKKKVDDDLGTIESLE 1391
Score = 55.5 bits (132), Expect = 8e-08
Identities = 62/267 (23%), Positives = 116/267 (43%), Gaps = 38/267 (14%)
Query: 107 ELTTEVNKLQKGIEMYNQE--------NSVYLSY---EKRAETLAVEIKELQGQLADYNM 155
E+ ++ KLQ ++ Y +E + ++ EK+ ++L EI +LQ +LA
Sbjct: 1642 EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSER 1701
Query: 156 LVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQAT 215
+ + E +E+ ++ + E++ E +I +EEE+E+E+
Sbjct: 1702 A--RRHAEQERDELADEIT-------NSASGKSALLDEKRRLEARIAQLEEELEEEQSNM 1752
Query: 216 DDIIKNMSFENQVKYLEMKTTNEKLL------QELDTLQQQLDSQNM----KKESLEAEI 265
+ + N F L++ T N +L Q+ D +QQL+ QN K + LE +
Sbjct: 1753 E--LLNDRFRKTT--LQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808
Query: 266 AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQ 325
S+ K L K+ +LE +Q E + + EK LK+I ++ R
Sbjct: 1809 K-SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEI---FMQVEDERRH 1864
Query: 326 LTDTKEKINQFIEEIRQLDMDLEEHQD 352
KE++ + ++QL LEE ++
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEEAEE 1891
Score = 53.9 bits (128), Expect = 2e-07
Identities = 81/360 (22%), Positives = 144/360 (40%), Gaps = 86/360 (23%)
Query: 93 DKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLAD 152
+K+ L +R+K + +++ + K E QE EK L E +LQ Q+A+
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQE------LEKAKRKLDGETTDLQDQIAE 1073
Query: 153 YNMLVDKLNTNTEM-------------EEVMNDYNMLKAQNDRETQ--SLDVIFTERQAK 197
+D+L +E ++ N LK + + Q L F +A
Sbjct: 1074 LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKAS 1133
Query: 198 ----EKQIRSVEEEIEQEKQATDDIIKNMSFENQV------------KYLEMKTTN-EKL 240
EKQ R + EE+E K +D + + + ++ K LE +T N E
Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQ 1193
Query: 241 LQE--------LDTLQQQLDSQNMKKESLE------------------------AEIAHS 268
+Q+ L+ L +QL+ K +LE AE H
Sbjct: 1194 IQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHK 1253
Query: 269 QVKQEAVL--LHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDN----QEIASM 322
+ K +A + LH K+ E + R ++ + + + ++ LL++ + ++ AS+
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASL 1313
Query: 323 ERQLTDTKEKINQ-------FIEEIRQLDMD---LEEHQDPTNYGWKILEKNTGSFKKQV 372
E QL DT+E + + IRQL+ + L+E Q+ K LEK + + Q+
Sbjct: 1314 ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL 1373
Score = 51.2 bits (121), Expect = 1e-06
Identities = 45/195 (23%), Positives = 95/195 (48%), Gaps = 17/195 (8%)
Query: 167 EEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFEN 226
++++ + N+L Q ET+ +F E + ++ + ++E+E+ + ++ N
Sbjct: 883 QQLLEEKNILAEQLQAETE----LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERN 938
Query: 227 QVKYLEMKTTNEKLLQELDTLQQQLDS-----QNMKKESLEAEIAHSQVKQEAVLLHE-- 279
Q+ E K K+ + L++QLD Q ++ E + AE ++++E +LL +
Sbjct: 939 QILQNEKK----KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQN 994
Query: 280 -KLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIE 338
K + + + IAE S + EE+ K L +I++ + + S + +EK Q +E
Sbjct: 995 SKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELE 1054
Query: 339 EI-RQLDMDLEEHQD 352
+ R+LD + + QD
Sbjct: 1055 KAKRKLDGETTDLQD 1069
Score = 50.4 bits (119), Expect = 2e-06
Identities = 60/287 (20%), Positives = 124/287 (43%), Gaps = 47/287 (16%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDK- 159
L S+I +L E N LQ+ QE E+ + L ++ LQ QLAD VD
Sbjct: 1334 LSSRIRQLEEEKNSLQE-----QQEEE-----EEARKNLEKQVLALQSQLADTKKKVDDD 1383
Query: 160 LNTNTEMEE----VMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQAT 215
L T +EE ++ D L + + + + D + + ++++ + +++ ++Q
Sbjct: 1384 LGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVA 1443
Query: 216 DDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESL-----EAEIAHSQV 270
++ K +Q+ E K+ + + +E D + + + K SL EA A +
Sbjct: 1444 SNLEKKQKKFDQL-LAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEF 1502
Query: 271 KQEAVLLHEKLYELESHRD-------QMIAEDKSIGSPMEEREKLLKQIKDDNQEI---- 319
+++ L + +L S +D ++ +++ +EE L++++D+ Q
Sbjct: 1503 ERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562
Query: 320 -----------ASMERQLT----DTKEKINQFIEEIRQLDMDLEEHQ 351
A ER L +EK I+++R+L+ +LE+ +
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDER 1609
Score = 50.4 bits (119), Expect = 2e-06
Identities = 61/260 (23%), Positives = 116/260 (44%), Gaps = 23/260 (8%)
Query: 107 ELTTEVNKLQKGIE-MYNQENSVYLSYEKRAETLAVEIKELQGQ-LADYNMLVDKLNTNT 164
++ + + K QK + + +E S+ Y + + E +E + + L+ L + L
Sbjct: 1441 QVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 165 EME----EVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVE---EEIEQEKQATDD 217
E E ++ D L + D +++ + ++A E+Q+ + EE+E E QAT+D
Sbjct: 1501 EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATED 1560
Query: 218 IIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKK-ESLEAEIAHSQVKQEAVL 276
+V MK E+ LQ D ++ +K+ LEAE+ + ++ +
Sbjct: 1561 ----AKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAV 1616
Query: 277 LHEKLYE--LESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEI----ASMERQLTDTK 330
+K E L+ Q+ A +K+ +++ KL Q+KD +E+ AS + +K
Sbjct: 1617 ASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK 1676
Query: 331 E---KINQFIEEIRQLDMDL 347
E K+ EI QL +L
Sbjct: 1677 ESEKKLKSLEAEILQLQEEL 1696
Score = 48.1 bits (113), Expect = 1e-05
Identities = 52/268 (19%), Positives = 113/268 (42%), Gaps = 29/268 (10%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLA--------- 151
LR+ + +L + + + K + + + E++ E + +++EL+ +L
Sbjct: 1509 LRADMEDLMSSKDDVGKNVHELEKSKR---ALEQQVEEMRTQLEELEDELQATEDAKLRL 1565
Query: 152 DYNMLVDK------LNTNTEMEE-----VMNDYNMLKAQNDRETQSLDVIFTERQAKEKQ 200
+ NM K L T E E ++ L+A+ + E + + ++ E
Sbjct: 1566 EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625
Query: 201 IRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKES 260
++ +E +IE +A D++IK + + Q + + + E+ D + Q K +S
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLR-KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKS 1684
Query: 261 LEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIA 320
LEAEI Q+++E E RD++ E I + + LL + + IA
Sbjct: 1685 LEAEIL--QLQEELASSERARRHAEQERDELADE---ITNSASGKSALLDEKRRLEARIA 1739
Query: 321 SMERQLTDTKEKINQFIEEIRQLDMDLE 348
+E +L + + + + R+ + ++
Sbjct: 1740 QLEEELEEEQSNMELLNDRFRKTTLQVD 1767
Score = 38.5 bits (88), Expect = 0.010
Identities = 39/155 (25%), Positives = 81/155 (52%), Gaps = 20/155 (12%)
Query: 197 KEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNM 256
+E+++++ +EE+ + K+ K E +++ +E K +++LL+E + L +QL ++
Sbjct: 850 QEEELQAKDEELLKVKE------KQTKVEGELEEMERK--HQQLLEEKNILAEQLQAET- 900
Query: 257 KKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKD-- 314
+ EAE +++ + L E L++LES ++ E++ E++K+ I+D
Sbjct: 901 -ELFAEAEEMRARLAAKKQELEEILHDLESRVEE---EEERNQILQNEKKKMQAHIQDLE 956
Query: 315 ---DNQEIASMERQL--TDTKEKINQFIEEIRQLD 344
D +E A + QL + KI + EEI L+
Sbjct: 957 EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLE 991
Score = 32.3 bits (72), Expect = 0.70
Identities = 27/174 (15%), Positives = 77/174 (44%), Gaps = 8/174 (4%)
Query: 179 QNDRETQSLDVI-FTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTN 237
+ +R+ + D+I F + + R + +Q+ A + +N + ++++ +
Sbjct: 779 EEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVF 838
Query: 238 EKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKS 297
K+ L +Q+ + Q +E L+ VK++ + +L E+E Q++ E
Sbjct: 839 TKVKPLLQVTRQEEELQAKDEELLK-------VKEKQTKVEGELEEMERKHQQLLEEKNI 891
Query: 298 IGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ 351
+ ++ +L + ++ +A+ +++L + + +EE + + L+ +
Sbjct: 892 LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK 945
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 70.1 bits (170), Expect = 3e-12
Identities = 68/275 (24%), Positives = 129/275 (46%), Gaps = 38/275 (13%)
Query: 106 SELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVD-----KL 160
+EL +V+KLQ +E + E +A LA ++ L QL D L+ KL
Sbjct: 1276 AELNDKVHKLQNEVESVT---GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1332
Query: 161 NTNTEMEEVMNDYNMLKAQNDRETQS----------LDVIFTERQAKEKQIRSVEEEIEQ 210
N +T++ ++ + N L+ Q D E ++ L++ ++ + K + S E +E+
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 211 EKQATDDIIKNMSFENQVK---YLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAH 267
K+ I+N++ + + K Y +++ T +L QELD L LD+Q +LE +
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK--- 1449
Query: 268 SQVKQEAVLLHEK----LYELESHRDQMIAEDK-----SIGSPMEEREKLLKQIKDDNQE 318
Q K + +L EK Y E R + A +K S+ +EE + ++++ N+
Sbjct: 1450 -QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 319 IASMERQLTDTKEKINQFIEEI----RQLDMDLEE 349
+ + L +K+ + + + E+ R L+ +EE
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Score = 64.7 bits (156), Expect = 1e-10
Identities = 67/290 (23%), Positives = 126/290 (43%), Gaps = 35/290 (12%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN 163
KI EL ++ LQ+ ++ E + EK+ L E++ L+ +L D +D T
Sbjct: 1112 KIRELEGHISDLQEDLD---SERAARNKAEKQKRDLGEELEALKTELED---TLDSTATQ 1165
Query: 164 TEMEEVMN-DYNMLKAQNDRETQSLDVIFTERQAKEKQ-IRSVEEEIEQEKQATDDIIKN 221
E+ + +LK D ET+S + E + K Q + + E++EQ K+A ++ KN
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK-----QEAVL 276
++ N L EL L Q KK+ LEA++ Q K +
Sbjct: 1226 KQ--------TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 277 LHEKLYELESHRDQMI-----AEDK---------SIGSPMEEREKLLKQIKDDNQEIASM 322
L++K+++L++ + + AE K S+ S +++ ++LL++ +++
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 323 ERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKKQV 372
RQL + + + ++E + +LE H N +K F V
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Score = 59.7 bits (143), Expect = 4e-09
Identities = 56/227 (24%), Positives = 110/227 (48%), Gaps = 19/227 (8%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDY-NMLKAQNDRETQSLDVIF 191
EK+A++L ++ +LQ LA + + E EE+ + + L +N +
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERA--RKQADLEKEELAEELASSLSGRN--------ALQ 1728
Query: 192 TERQAKEKQIRSVEEEIEQEK---QATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQ 248
E++ E +I +EEE+E+E+ +A D ++ + + + E+ T Q+ ++ +
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL-ATERSTAQKNESAR 1787
Query: 249 QQLDSQNMKKESLEAEI---AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEER 305
QQL+ QN + S E+ S+ K L K+ +LE +Q E ++ ++++
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEI-RQLDMDLEEHQ 351
+K LK+I ++ M Q + EK N ++++ RQL+ EE Q
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1894
Score = 55.5 bits (132), Expect = 8e-08
Identities = 69/327 (21%), Positives = 149/327 (45%), Gaps = 52/327 (15%)
Query: 74 QQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYE 133
QQ LT MK + + +++ L +K+ L +V + ++ ++ E +
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLL-QVTRQEEEMQAKEDELQKTKERQ 868
Query: 134 KRAETLAVEIKELQGQLADY-NMLVDKLNTNTEM------------------EEVMNDYN 174
++AE E+++ QL + N+L ++L TE+ EE++++
Sbjct: 869 QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME 928
Query: 175 M-LKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI-IKNMSFENQVKYLE 232
L+ + DR Q + ER+ +Q+ +EE++E+E+ A + ++ ++ E ++K LE
Sbjct: 929 ARLEEEEDRGQQ----LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 984
Query: 233 -----MKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESH 287
M N KL +E L++++ L +A + K + L +L++
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERI-------SDLTTNLAEEEEKA------KNLTKLKNK 1031
Query: 288 RDQMIAE----DKSIGSPMEEREKLLKQIKDD----NQEIASMERQLTDTKEKINQFIEE 339
+ MI+E K +E EKL ++++ D +++IA ++ Q+ + K ++ + EE
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 340 IRQLDMDLEEHQDPTNYGWKILEKNTG 366
++ L++ N K + + G
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEG 1118
Score = 52.8 bits (125), Expect = 5e-07
Identities = 61/288 (21%), Positives = 124/288 (43%), Gaps = 37/288 (12%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDK- 159
L K S+LT E N LQ E E +Y E+ LA + +EL+ L + +++
Sbjct: 878 LEQKHSQLTEEKNLLQ---EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 934
Query: 160 ----LNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEI------- 208
E +++ L+ Q + E + + E+ E +I+ +E+EI
Sbjct: 935 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 209 ---EQEKQATDDIIKNMSF-----ENQVKYL-EMKTTNEKLLQELDTLQQQLDSQNMKKE 259
+E++ ++ I +++ E + K L ++K +E ++ EL+ ++ + + E
Sbjct: 995 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 260 SLEAEIA------HSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIK 313
L+ ++ H Q+ + E +L +++ A + + ++ LK+I+
Sbjct: 1055 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1114
Query: 314 D------DNQEIASMERQLTDTKEKINQFI-EEIRQLDMDLEEHQDPT 354
+ D QE ER + EK + + EE+ L +LE+ D T
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162
Score = 46.2 bits (108), Expect = 5e-05
Identities = 64/286 (22%), Positives = 114/286 (39%), Gaps = 38/286 (13%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
Q+++ D L R +S L + K + + +S Y RAE A E +
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEE 207
LA L + L E+E MLKA+ + S D + EK R++E +
Sbjct: 1486 LSLA--RALEEALEAKEELERTNK---MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 208 IEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAH 267
+E+ K +++ + K L ++ + L + + Q D QN +K
Sbjct: 1541 MEEMKTQLEELEDELQATEDAK-LRLEVNMQALKGQFERDLQARDEQNEEKR-------- 1591
Query: 268 SQVKQEAVLLHEKLYELESHRDQ----MIAEDKSIG----------SPMEEREKLLKQIK 313
+Q LHE ELE R Q A+ K G S ++ RE+ +KQ++
Sbjct: 1592 ---RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648
Query: 314 DDNQEIASMERQLTDTKEKINQFI-------EEIRQLDMDLEEHQD 352
++ +R+L D + ++ ++ + L+ DL + Q+
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694
Score = 45.4 bits (106), Expect = 8e-05
Identities = 56/289 (19%), Positives = 124/289 (42%), Gaps = 19/289 (6%)
Query: 101 LRSKISEL-----TTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNM 155
+++++ EL TE KL+ + M + + R E + ++LQ QL +Y
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603
Query: 156 LVDKLNTNTEM-----EEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQ 210
++ + +++ D L+ Q D + + + + + Q++ + E+E
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 211 EKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQV 270
+ + D+I EN+ K ++ +L ++L ++ +++KE L E+A S
Sbjct: 1664 ARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722
Query: 271 KQEAVLLHEKLYELE-SHRDQMIAEDKSIGSPMEER-EKLLKQIKDDNQEIASMERQLTD 328
+ A+ ++ E + ++ + E++ M +R K +Q + + E+A+ ER
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-ERSTAQ 1781
Query: 329 TKEKINQFIE-EIRQLDMDLEEHQDPTNYGWK----ILEKNTGSFKKQV 372
E Q +E + ++L L E + +K LE ++QV
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 70.1 bits (170), Expect = 3e-12
Identities = 68/275 (24%), Positives = 129/275 (46%), Gaps = 38/275 (13%)
Query: 106 SELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVD-----KL 160
+EL +V+KLQ +E + E +A LA ++ L QL D L+ KL
Sbjct: 1283 AELNDKVHKLQNEVESVT---GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1339
Query: 161 NTNTEMEEVMNDYNMLKAQNDRETQS----------LDVIFTERQAKEKQIRSVEEEIEQ 210
N +T++ ++ + N L+ Q D E ++ L++ ++ + K + S E +E+
Sbjct: 1340 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 211 EKQATDDIIKNMSFENQVK---YLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAH 267
K+ I+N++ + + K Y +++ T +L QELD L LD+Q +LE +
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK--- 1456
Query: 268 SQVKQEAVLLHEK----LYELESHRDQMIAEDK-----SIGSPMEEREKLLKQIKDDNQE 318
Q K + +L EK Y E R + A +K S+ +EE + ++++ N+
Sbjct: 1457 -QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515
Query: 319 IASMERQLTDTKEKINQFIEEI----RQLDMDLEE 349
+ + L +K+ + + + E+ R L+ +EE
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Score = 64.7 bits (156), Expect = 1e-10
Identities = 67/290 (23%), Positives = 126/290 (43%), Gaps = 35/290 (12%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN 163
KI EL ++ LQ+ ++ E + EK+ L E++ L+ +L D +D T
Sbjct: 1119 KIRELEGHISDLQEDLD---SERAARNKAEKQKRDLGEELEALKTELED---TLDSTATQ 1172
Query: 164 TEMEEVMN-DYNMLKAQNDRETQSLDVIFTERQAKEKQ-IRSVEEEIEQEKQATDDIIKN 221
E+ + +LK D ET+S + E + K Q + + E++EQ K+A ++ KN
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK-----QEAVL 276
++ N L EL L Q KK+ LEA++ Q K +
Sbjct: 1233 KQ--------TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 277 LHEKLYELESHRDQMI-----AEDK---------SIGSPMEEREKLLKQIKDDNQEIASM 322
L++K+++L++ + + AE K S+ S +++ ++LL++ +++
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 323 ERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKKQV 372
RQL + + + ++E + +LE H N +K F V
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Score = 59.7 bits (143), Expect = 4e-09
Identities = 56/227 (24%), Positives = 110/227 (48%), Gaps = 19/227 (8%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDY-NMLKAQNDRETQSLDVIF 191
EK+A++L ++ +LQ LA + + E EE+ + + L +N +
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERA--RKQADLEKEELAEELASSLSGRN--------ALQ 1735
Query: 192 TERQAKEKQIRSVEEEIEQEK---QATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQ 248
E++ E +I +EEE+E+E+ +A D ++ + + + E+ T Q+ ++ +
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL-ATERSTAQKNESAR 1794
Query: 249 QQLDSQNMKKESLEAEI---AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEER 305
QQL+ QN + S E+ S+ K L K+ +LE +Q E ++ ++++
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEI-RQLDMDLEEHQ 351
+K LK+I ++ M Q + EK N ++++ RQL+ EE Q
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1901
Score = 55.5 bits (132), Expect = 8e-08
Identities = 69/327 (21%), Positives = 149/327 (45%), Gaps = 52/327 (15%)
Query: 74 QQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYE 133
QQ LT MK + + +++ L +K+ L +V + ++ ++ E +
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLL-QVTRQEEEMQAKEDELQKTKERQ 875
Query: 134 KRAETLAVEIKELQGQLADY-NMLVDKLNTNTEM------------------EEVMNDYN 174
++AE E+++ QL + N+L ++L TE+ EE++++
Sbjct: 876 QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME 935
Query: 175 M-LKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI-IKNMSFENQVKYLE 232
L+ + DR Q + ER+ +Q+ +EE++E+E+ A + ++ ++ E ++K LE
Sbjct: 936 ARLEEEEDRGQQ----LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 991
Query: 233 -----MKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESH 287
M N KL +E L++++ L +A + K + L +L++
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERI-------SDLTTNLAEEEEKA------KNLTKLKNK 1038
Query: 288 RDQMIAE----DKSIGSPMEEREKLLKQIKDD----NQEIASMERQLTDTKEKINQFIEE 339
+ MI+E K +E EKL ++++ D +++IA ++ Q+ + K ++ + EE
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 340 IRQLDMDLEEHQDPTNYGWKILEKNTG 366
++ L++ N K + + G
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEG 1125
Score = 52.8 bits (125), Expect = 5e-07
Identities = 61/288 (21%), Positives = 124/288 (43%), Gaps = 37/288 (12%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDK- 159
L K S+LT E N LQ E E +Y E+ LA + +EL+ L + +++
Sbjct: 885 LEQKHSQLTEEKNLLQ---EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 941
Query: 160 ----LNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEI------- 208
E +++ L+ Q + E + + E+ E +I+ +E+EI
Sbjct: 942 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 209 ---EQEKQATDDIIKNMSF-----ENQVKYL-EMKTTNEKLLQELDTLQQQLDSQNMKKE 259
+E++ ++ I +++ E + K L ++K +E ++ EL+ ++ + + E
Sbjct: 1002 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 260 SLEAEIA------HSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIK 313
L+ ++ H Q+ + E +L +++ A + + ++ LK+I+
Sbjct: 1062 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1121
Query: 314 D------DNQEIASMERQLTDTKEKINQFI-EEIRQLDMDLEEHQDPT 354
+ D QE ER + EK + + EE+ L +LE+ D T
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169
Score = 46.2 bits (108), Expect = 5e-05
Identities = 64/286 (22%), Positives = 114/286 (39%), Gaps = 38/286 (13%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
Q+++ D L R +S L + K + + +S Y RAE A E +
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEE 207
LA L + L E+E MLKA+ + S D + EK R++E +
Sbjct: 1493 LSLA--RALEEALEAKEELERTNK---MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 208 IEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAH 267
+E+ K +++ + K L ++ + L + + Q D QN +K
Sbjct: 1548 MEEMKTQLEELEDELQATEDAK-LRLEVNMQALKGQFERDLQARDEQNEEKR-------- 1598
Query: 268 SQVKQEAVLLHEKLYELESHRDQ----MIAEDKSIG----------SPMEEREKLLKQIK 313
+Q LHE ELE R Q A+ K G S ++ RE+ +KQ++
Sbjct: 1599 ---RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655
Query: 314 DDNQEIASMERQLTDTKEKINQFI-------EEIRQLDMDLEEHQD 352
++ +R+L D + ++ ++ + L+ DL + Q+
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701
Score = 45.4 bits (106), Expect = 8e-05
Identities = 56/289 (19%), Positives = 124/289 (42%), Gaps = 19/289 (6%)
Query: 101 LRSKISEL-----TTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNM 155
+++++ EL TE KL+ + M + + R E + ++LQ QL +Y
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610
Query: 156 LVDKLNTNTEM-----EEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQ 210
++ + +++ D L+ Q D + + + + + Q++ + E+E
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 211 EKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQV 270
+ + D+I EN+ K ++ +L ++L ++ +++KE L E+A S
Sbjct: 1671 ARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729
Query: 271 KQEAVLLHEKLYELE-SHRDQMIAEDKSIGSPMEER-EKLLKQIKDDNQEIASMERQLTD 328
+ A+ ++ E + ++ + E++ M +R K +Q + + E+A+ ER
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-ERSTAQ 1788
Query: 329 TKEKINQFIE-EIRQLDMDLEEHQDPTNYGWK----ILEKNTGSFKKQV 372
E Q +E + ++L L E + +K LE ++QV
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1837
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 70.1 bits (170), Expect = 3e-12
Identities = 68/275 (24%), Positives = 129/275 (46%), Gaps = 38/275 (13%)
Query: 106 SELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVD-----KL 160
+EL +V+KLQ +E + E +A LA ++ L QL D L+ KL
Sbjct: 1283 AELNDKVHKLQNEVESVT---GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1339
Query: 161 NTNTEMEEVMNDYNMLKAQNDRETQS----------LDVIFTERQAKEKQIRSVEEEIEQ 210
N +T++ ++ + N L+ Q D E ++ L++ ++ + K + S E +E+
Sbjct: 1340 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 211 EKQATDDIIKNMSFENQVK---YLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAH 267
K+ I+N++ + + K Y +++ T +L QELD L LD+Q +LE +
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK--- 1456
Query: 268 SQVKQEAVLLHEK----LYELESHRDQMIAEDK-----SIGSPMEEREKLLKQIKDDNQE 318
Q K + +L EK Y E R + A +K S+ +EE + ++++ N+
Sbjct: 1457 -QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515
Query: 319 IASMERQLTDTKEKINQFIEEI----RQLDMDLEE 349
+ + L +K+ + + + E+ R L+ +EE
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Score = 64.7 bits (156), Expect = 1e-10
Identities = 67/290 (23%), Positives = 126/290 (43%), Gaps = 35/290 (12%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN 163
KI EL ++ LQ+ ++ E + EK+ L E++ L+ +L D +D T
Sbjct: 1119 KIRELEGHISDLQEDLD---SERAARNKAEKQKRDLGEELEALKTELED---TLDSTATQ 1172
Query: 164 TEMEEVMN-DYNMLKAQNDRETQSLDVIFTERQAKEKQ-IRSVEEEIEQEKQATDDIIKN 221
E+ + +LK D ET+S + E + K Q + + E++EQ K+A ++ KN
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK-----QEAVL 276
++ N L EL L Q KK+ LEA++ Q K +
Sbjct: 1233 KQ--------TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 277 LHEKLYELESHRDQMI-----AEDK---------SIGSPMEEREKLLKQIKDDNQEIASM 322
L++K+++L++ + + AE K S+ S +++ ++LL++ +++
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 323 ERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKKQV 372
RQL + + + ++E + +LE H N +K F V
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Score = 59.7 bits (143), Expect = 4e-09
Identities = 56/227 (24%), Positives = 110/227 (48%), Gaps = 19/227 (8%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDY-NMLKAQNDRETQSLDVIF 191
EK+A++L ++ +LQ LA + + E EE+ + + L +N +
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERA--RKQADLEKEELAEELASSLSGRN--------ALQ 1735
Query: 192 TERQAKEKQIRSVEEEIEQEK---QATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQ 248
E++ E +I +EEE+E+E+ +A D ++ + + + E+ T Q+ ++ +
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL-ATERSTAQKNESAR 1794
Query: 249 QQLDSQNMKKESLEAEI---AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEER 305
QQL+ QN + S E+ S+ K L K+ +LE +Q E ++ ++++
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEI-RQLDMDLEEHQ 351
+K LK+I ++ M Q + EK N ++++ RQL+ EE Q
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1901
Score = 55.5 bits (132), Expect = 8e-08
Identities = 69/327 (21%), Positives = 149/327 (45%), Gaps = 52/327 (15%)
Query: 74 QQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYE 133
QQ LT MK + + +++ L +K+ L +V + ++ ++ E +
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLL-QVTRQEEEMQAKEDELQKTKERQ 875
Query: 134 KRAETLAVEIKELQGQLADY-NMLVDKLNTNTEM------------------EEVMNDYN 174
++AE E+++ QL + N+L ++L TE+ EE++++
Sbjct: 876 QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME 935
Query: 175 M-LKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI-IKNMSFENQVKYLE 232
L+ + DR Q + ER+ +Q+ +EE++E+E+ A + ++ ++ E ++K LE
Sbjct: 936 ARLEEEEDRGQQ----LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 991
Query: 233 -----MKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESH 287
M N KL +E L++++ L +A + K + L +L++
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERI-------SDLTTNLAEEEEKA------KNLTKLKNK 1038
Query: 288 RDQMIAE----DKSIGSPMEEREKLLKQIKDD----NQEIASMERQLTDTKEKINQFIEE 339
+ MI+E K +E EKL ++++ D +++IA ++ Q+ + K ++ + EE
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 340 IRQLDMDLEEHQDPTNYGWKILEKNTG 366
++ L++ N K + + G
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEG 1125
Score = 52.8 bits (125), Expect = 5e-07
Identities = 61/288 (21%), Positives = 124/288 (43%), Gaps = 37/288 (12%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDK- 159
L K S+LT E N LQ E E +Y E+ LA + +EL+ L + +++
Sbjct: 885 LEQKHSQLTEEKNLLQ---EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 941
Query: 160 ----LNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEI------- 208
E +++ L+ Q + E + + E+ E +I+ +E+EI
Sbjct: 942 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 209 ---EQEKQATDDIIKNMSF-----ENQVKYL-EMKTTNEKLLQELDTLQQQLDSQNMKKE 259
+E++ ++ I +++ E + K L ++K +E ++ EL+ ++ + + E
Sbjct: 1002 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 260 SLEAEIA------HSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIK 313
L+ ++ H Q+ + E +L +++ A + + ++ LK+I+
Sbjct: 1062 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1121
Query: 314 D------DNQEIASMERQLTDTKEKINQFI-EEIRQLDMDLEEHQDPT 354
+ D QE ER + EK + + EE+ L +LE+ D T
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169
Score = 46.2 bits (108), Expect = 5e-05
Identities = 64/286 (22%), Positives = 114/286 (39%), Gaps = 38/286 (13%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
Q+++ D L R +S L + K + + +S Y RAE A E +
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEE 207
LA L + L E+E MLKA+ + S D + EK R++E +
Sbjct: 1493 LSLA--RALEEALEAKEELERTNK---MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 208 IEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAH 267
+E+ K +++ + K L ++ + L + + Q D QN +K
Sbjct: 1548 MEEMKTQLEELEDELQATEDAK-LRLEVNMQALKGQFERDLQARDEQNEEKR-------- 1598
Query: 268 SQVKQEAVLLHEKLYELESHRDQ----MIAEDKSIG----------SPMEEREKLLKQIK 313
+Q LHE ELE R Q A+ K G S ++ RE+ +KQ++
Sbjct: 1599 ---RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655
Query: 314 DDNQEIASMERQLTDTKEKINQFI-------EEIRQLDMDLEEHQD 352
++ +R+L D + ++ ++ + L+ DL + Q+
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701
Score = 45.4 bits (106), Expect = 8e-05
Identities = 56/289 (19%), Positives = 124/289 (42%), Gaps = 19/289 (6%)
Query: 101 LRSKISEL-----TTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNM 155
+++++ EL TE KL+ + M + + R E + ++LQ QL +Y
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610
Query: 156 LVDKLNTNTEM-----EEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQ 210
++ + +++ D L+ Q D + + + + + Q++ + E+E
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 211 EKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQV 270
+ + D+I EN+ K ++ +L ++L ++ +++KE L E+A S
Sbjct: 1671 ARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729
Query: 271 KQEAVLLHEKLYELE-SHRDQMIAEDKSIGSPMEER-EKLLKQIKDDNQEIASMERQLTD 328
+ A+ ++ E + ++ + E++ M +R K +Q + + E+A+ ER
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-ERSTAQ 1788
Query: 329 TKEKINQFIE-EIRQLDMDLEEHQDPTNYGWK----ILEKNTGSFKKQV 372
E Q +E + ++L L E + +K LE ++QV
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1837
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 70.1 bits (170), Expect = 3e-12
Identities = 68/275 (24%), Positives = 129/275 (46%), Gaps = 38/275 (13%)
Query: 106 SELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVD-----KL 160
+EL +V+KLQ +E + E +A LA ++ L QL D L+ KL
Sbjct: 1276 AELNDKVHKLQNEVESVT---GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1332
Query: 161 NTNTEMEEVMNDYNMLKAQNDRETQS----------LDVIFTERQAKEKQIRSVEEEIEQ 210
N +T++ ++ + N L+ Q D E ++ L++ ++ + K + S E +E+
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 211 EKQATDDIIKNMSFENQVK---YLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAH 267
K+ I+N++ + + K Y +++ T +L QELD L LD+Q +LE +
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK--- 1449
Query: 268 SQVKQEAVLLHEK----LYELESHRDQMIAEDK-----SIGSPMEEREKLLKQIKDDNQE 318
Q K + +L EK Y E R + A +K S+ +EE + ++++ N+
Sbjct: 1450 -QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 319 IASMERQLTDTKEKINQFIEEI----RQLDMDLEE 349
+ + L +K+ + + + E+ R L+ +EE
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Score = 64.7 bits (156), Expect = 1e-10
Identities = 67/290 (23%), Positives = 126/290 (43%), Gaps = 35/290 (12%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN 163
KI EL ++ LQ+ ++ E + EK+ L E++ L+ +L D +D T
Sbjct: 1112 KIRELEGHISDLQEDLD---SERAARNKAEKQKRDLGEELEALKTELED---TLDSTATQ 1165
Query: 164 TEMEEVMN-DYNMLKAQNDRETQSLDVIFTERQAKEKQ-IRSVEEEIEQEKQATDDIIKN 221
E+ + +LK D ET+S + E + K Q + + E++EQ K+A ++ KN
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK-----QEAVL 276
++ N L EL L Q KK+ LEA++ Q K +
Sbjct: 1226 KQ--------TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 277 LHEKLYELESHRDQMI-----AEDK---------SIGSPMEEREKLLKQIKDDNQEIASM 322
L++K+++L++ + + AE K S+ S +++ ++LL++ +++
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 323 ERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKKQV 372
RQL + + + ++E + +LE H N +K F V
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Score = 59.7 bits (143), Expect = 4e-09
Identities = 56/227 (24%), Positives = 110/227 (48%), Gaps = 19/227 (8%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDY-NMLKAQNDRETQSLDVIF 191
EK+A++L ++ +LQ LA + + E EE+ + + L +N +
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERA--RKQADLEKEELAEELASSLSGRN--------ALQ 1728
Query: 192 TERQAKEKQIRSVEEEIEQEK---QATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQ 248
E++ E +I +EEE+E+E+ +A D ++ + + + E+ T Q+ ++ +
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL-ATERSTAQKNESAR 1787
Query: 249 QQLDSQNMKKESLEAEI---AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEER 305
QQL+ QN + S E+ S+ K L K+ +LE +Q E ++ ++++
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEI-RQLDMDLEEHQ 351
+K LK+I ++ M Q + EK N ++++ RQL+ EE Q
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1894
Score = 55.5 bits (132), Expect = 8e-08
Identities = 69/327 (21%), Positives = 149/327 (45%), Gaps = 52/327 (15%)
Query: 74 QQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYE 133
QQ LT MK + + +++ L +K+ L +V + ++ ++ E +
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLL-QVTRQEEEMQAKEDELQKTKERQ 868
Query: 134 KRAETLAVEIKELQGQLADY-NMLVDKLNTNTEM------------------EEVMNDYN 174
++AE E+++ QL + N+L ++L TE+ EE++++
Sbjct: 869 QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME 928
Query: 175 M-LKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI-IKNMSFENQVKYLE 232
L+ + DR Q + ER+ +Q+ +EE++E+E+ A + ++ ++ E ++K LE
Sbjct: 929 ARLEEEEDRGQQ----LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 984
Query: 233 -----MKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESH 287
M N KL +E L++++ L +A + K + L +L++
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERI-------SDLTTNLAEEEEKA------KNLTKLKNK 1031
Query: 288 RDQMIAE----DKSIGSPMEEREKLLKQIKDD----NQEIASMERQLTDTKEKINQFIEE 339
+ MI+E K +E EKL ++++ D +++IA ++ Q+ + K ++ + EE
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 340 IRQLDMDLEEHQDPTNYGWKILEKNTG 366
++ L++ N K + + G
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEG 1118
Score = 52.8 bits (125), Expect = 5e-07
Identities = 61/288 (21%), Positives = 124/288 (43%), Gaps = 37/288 (12%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDK- 159
L K S+LT E N LQ E E +Y E+ LA + +EL+ L + +++
Sbjct: 878 LEQKHSQLTEEKNLLQ---EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 934
Query: 160 ----LNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEI------- 208
E +++ L+ Q + E + + E+ E +I+ +E+EI
Sbjct: 935 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 209 ---EQEKQATDDIIKNMSF-----ENQVKYL-EMKTTNEKLLQELDTLQQQLDSQNMKKE 259
+E++ ++ I +++ E + K L ++K +E ++ EL+ ++ + + E
Sbjct: 995 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 260 SLEAEIA------HSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIK 313
L+ ++ H Q+ + E +L +++ A + + ++ LK+I+
Sbjct: 1055 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1114
Query: 314 D------DNQEIASMERQLTDTKEKINQFI-EEIRQLDMDLEEHQDPT 354
+ D QE ER + EK + + EE+ L +LE+ D T
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162
Score = 46.2 bits (108), Expect = 5e-05
Identities = 64/286 (22%), Positives = 114/286 (39%), Gaps = 38/286 (13%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
Q+++ D L R +S L + K + + +S Y RAE A E +
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEE 207
LA L + L E+E MLKA+ + S D + EK R++E +
Sbjct: 1486 LSLA--RALEEALEAKEELERTNK---MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 208 IEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAH 267
+E+ K +++ + K L ++ + L + + Q D QN +K
Sbjct: 1541 MEEMKTQLEELEDELQATEDAK-LRLEVNMQALKGQFERDLQARDEQNEEKR-------- 1591
Query: 268 SQVKQEAVLLHEKLYELESHRDQ----MIAEDKSIG----------SPMEEREKLLKQIK 313
+Q LHE ELE R Q A+ K G S ++ RE+ +KQ++
Sbjct: 1592 ---RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648
Query: 314 DDNQEIASMERQLTDTKEKINQFI-------EEIRQLDMDLEEHQD 352
++ +R+L D + ++ ++ + L+ DL + Q+
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694
Score = 45.4 bits (106), Expect = 8e-05
Identities = 56/289 (19%), Positives = 124/289 (42%), Gaps = 19/289 (6%)
Query: 101 LRSKISEL-----TTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNM 155
+++++ EL TE KL+ + M + + R E + ++LQ QL +Y
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603
Query: 156 LVDKLNTNTEM-----EEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQ 210
++ + +++ D L+ Q D + + + + + Q++ + E+E
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 211 EKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQV 270
+ + D+I EN+ K ++ +L ++L ++ +++KE L E+A S
Sbjct: 1664 ARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722
Query: 271 KQEAVLLHEKLYELE-SHRDQMIAEDKSIGSPMEER-EKLLKQIKDDNQEIASMERQLTD 328
+ A+ ++ E + ++ + E++ M +R K +Q + + E+A+ ER
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-ERSTAQ 1781
Query: 329 TKEKINQFIE-EIRQLDMDLEEHQDPTNYGWK----ILEKNTGSFKKQV 372
E Q +E + ++L L E + +K LE ++QV
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 70.1 bits (170), Expect = 3e-12
Identities = 60/262 (22%), Positives = 136/262 (51%), Gaps = 32/262 (12%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQ--ENSVYLSYEKRAETLAVEIKELQGQLADYNMLVD 158
LR +SE TE++ +QK +E N +N + YEK + +I E+Q ++ + +
Sbjct: 1496 LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKE 1555
Query: 159 -KLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDD 217
+ ++ ++ + + L + + + ++ E++ ++ +++ E +Q K+ T +
Sbjct: 1556 HRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKE 1615
Query: 218 IIKNM--SFENQVKYLEMKTTNE--KLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQE 273
I+ M S E + ++L+M NE + + E++ L++Q ++Q + E++E E + ++ Q
Sbjct: 1616 IVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETE--NIRLTQ- 1672
Query: 274 AVLLHEKLYELES---HRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTK 330
+LHE L E+ S RD + + ++++ ER++L + +++ T T+
Sbjct: 1673 --ILHENLEEMRSVTKERDDLRSVEETL---KVERDQLKENLRE------------TITR 1715
Query: 331 EKINQFIEEIRQLDMDLEEHQD 352
+ Q EE++ + M L+EHQ+
Sbjct: 1716 DLEKQ--EELKIVHMHLKEHQE 1735
Score = 57.8 bits (138), Expect = 2e-08
Identities = 67/299 (22%), Positives = 137/299 (45%), Gaps = 45/299 (15%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAE----TLAVEI 143
Q++ +DK LR +SE T +++ +QK +E N + + K E TL ++
Sbjct: 1786 QQETIDK------LRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDV 1839
Query: 144 KELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRET-QSLDVIFTERQAKEKQIR 202
E Q ++++ L ++ + + N+ AQ E + + + ER +R
Sbjct: 1840 NETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD----NLR 1895
Query: 203 SVEEEIEQEKQATDDII-----KNMSFENQVKYLEM-----KTTNEKLLQ-------ELD 245
VEE ++ E+ + + +++ + ++K M K T +KL + ++
Sbjct: 1896 RVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQIS 1955
Query: 246 TLQQQLDS-----QNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGS 300
+Q+ LD Q +E + E+ +VK++ + H+K+ E+E + Q A++ S+ S
Sbjct: 1956 DIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQS 2015
Query: 301 PMEEREKLLKQIKDDNQEI---ASMERQLTDTKEKI----NQFIEEIRQ-LDMDLEEHQ 351
+ +L K++ + +EI A +L KE + +QFI +R+ + D + HQ
Sbjct: 2016 VRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQ 2074
Score = 57.0 bits (136), Expect = 3e-08
Identities = 61/309 (19%), Positives = 134/309 (43%), Gaps = 65/309 (21%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQE----NSVYLSYEKRAETLAVEIK------------ 144
L+ K+ EL T +++ I++Y + + + EK ++ EI
Sbjct: 651 LKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPK 710
Query: 145 ------ELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQ---------------NDRE 183
EL+G++ D L +LN E E + + +L ++ D+
Sbjct: 711 DLLCNLELEGKITD---LQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKS 767
Query: 184 ------TQSLDVIFTERQAKEKQIRSVEEEIEQEK----------QATDDIIKN-----M 222
T D +F+E KE +++ + EEI + K ++TD +N M
Sbjct: 768 EELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHM 827
Query: 223 SFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHS--QVKQEAVLLHEK 280
FE KY + NE++ QE+ L ++ + +L+ E+++ +++++ + E+
Sbjct: 828 DFEQ--KYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQER 885
Query: 281 LYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEI 340
L E+E ++Q+ D ++ + E+ + ++++ +E+ ++ ++ D K+ E
Sbjct: 886 LNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIER 945
Query: 341 RQLDMDLEE 349
QL D+ +
Sbjct: 946 DQLKSDIHD 954
Score = 55.5 bits (132), Expect = 8e-08
Identities = 57/272 (20%), Positives = 130/272 (47%), Gaps = 30/272 (11%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVY-LSYEKRAETLAVEIKE-------LQGQLAD 152
LR +SE T E++ +QK +E N L ++ + +KE L+G +++
Sbjct: 1740 LRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSE 1799
Query: 153 Y-----NMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEE 207
NM D N+N +++E + + LKA N+ + +L E Q K ++ ++++
Sbjct: 1800 KTDKLSNMQKDLENSNAKLQEKIQE---LKA-NEHQLITLKKDVNETQKKVSEMEQLKKQ 1855
Query: 208 IEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAH 267
I+ + + +++ L + + L+E+ ++ ++ D+ +E+L+ E
Sbjct: 1856 IKDQSLTLSKL--------EIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLE--R 1905
Query: 268 SQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLT 327
Q+K+ L K +LE ++ A S E +KL ++I + +I+ +++ L
Sbjct: 1906 DQLKES--LQETKARDLEIQQELKTARMLS-KEHKETVDKLREKISEKTIQISDIQKDLD 1962
Query: 328 DTKEKINQFIEEIRQLDMDLEEHQDPTNYGWK 359
+K+++ + I+E+++ ++ L ++ N K
Sbjct: 1963 KSKDELQKKIQELQKKELQLLRVKEDVNMSHK 1994
Score = 52.8 bits (125), Expect = 5e-07
Identities = 57/276 (20%), Positives = 120/276 (43%), Gaps = 28/276 (10%)
Query: 114 KLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNT-EMEEVMND 172
K + +E + N ++ K A+ + L+ +L+ +L T E++E +N+
Sbjct: 832 KYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELS---YKTQELQEKTREVQERLNE 888
Query: 173 YNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLE 232
LK Q + +L + E+ ++++ EE++ Q DD+ K + Q++ +
Sbjct: 889 MEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDL-KQLQESLQIERDQ 947
Query: 233 MKT-----------TNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKL 281
+K+ T E+L L++L+Q ++ N K + E++ + + + E
Sbjct: 948 LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN------LHMEENT 1001
Query: 282 YELESHRDQ-MIAEDKSIGSPMEEREKLLKQIKDDN-----QEIASMERQLTDTKEKINQ 335
E + Q M+ DK + + L +KD+ ++I S+ ++ + ++ +
Sbjct: 1002 GETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLES 1061
Query: 336 FIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKKQ 371
I E QL DL+E+ + T + L KKQ
Sbjct: 1062 VIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQ 1097
Score = 48.9 bits (115), Expect = 7e-06
Identities = 60/305 (19%), Positives = 132/305 (43%), Gaps = 43/305 (14%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
++QI D+S L L + L KL + +E + + ETL +E +L+
Sbjct: 1853 KKQIKDQSLTLSKLEIENLNLA---QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLK 1909
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEE 207
L + T E+ + + + +++D + + K QI ++++
Sbjct: 1910 ESLQE---------TKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKD 1960
Query: 208 IEQEKQATDDIIKNMSFENQVKYLEMK---TTNEKLLQELDTLQQQLDSQNMKKESLEAE 264
+++ K I+ + + +++ L +K + K + E++ L++Q ++QN+ +S+ +
Sbjct: 1961 LDKSKDELQKKIQELQ-KKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMD 2019
Query: 265 IAHSQVKQEAVLLHEKLYE-----------------LESHRDQMIAEDKSIGSPMEEREK 307
K LHE L E L+ RDQ IA + M R++
Sbjct: 2020 NFQLTKK-----LHESLEEIRIVAKERDELRRIKESLKMERDQFIATLRE----MIARDR 2070
Query: 308 LLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGS 367
Q+K + + ++ ++ LT++ + I+E+ + ++++H + N LEK
Sbjct: 2071 QNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEI-E 2129
Query: 368 FKKQV 372
F+K++
Sbjct: 2130 FQKEL 2134
Score = 46.2 bits (108), Expect = 5e-05
Identities = 42/245 (17%), Positives = 115/245 (46%), Gaps = 32/245 (13%)
Query: 105 ISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNT 164
+ E E K+ +E + ++S L E L+ ++E ++ +
Sbjct: 1392 MKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMK---------SVAK 1442
Query: 165 EMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSF 224
E +++ +L++++D+ +++ I + E++++ ++++++ +++ N+S
Sbjct: 1443 EKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLS- 1501
Query: 225 ENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK---QEAVLLHEKL 281
E +T E+ T+Q+QL++ N K ++ EI + + ++ + EK+
Sbjct: 1502 -------EKET-------EISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547
Query: 282 YELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIR 341
EL+ ++ A+D ++ S + +L ++++ +EI M ++ + K ++E
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKR-----VQEAL 1602
Query: 342 QLDMD 346
Q++ D
Sbjct: 1603 QIERD 1607
Score = 45.8 bits (107), Expect = 6e-05
Identities = 50/281 (17%), Positives = 130/281 (46%), Gaps = 37/281 (13%)
Query: 98 LGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLV 157
+ L+SKISE EV++ ++ +EN+ E + + + ++ K+ + + L
Sbjct: 980 INTLKSKISE---EVSR-----NLHMEENTGETKDEFQQKMVGIDKKQ-DLEAKNTQTLT 1030
Query: 158 DKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQAT-- 215
+ N +E+ +++++ +N+ + VI + Q K ++E IE +++
Sbjct: 1031 ADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLL 1090
Query: 216 -DDIIKNMSFENQVKYLEMKTTNE--KLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQ 272
D++ K Q K +K E + L ++++L ++ + + + ++ + V++
Sbjct: 1091 GDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLN--VQE 1148
Query: 273 EAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEK 332
E + +K+ E+E+ ++++ ++ ++ ER +L +++ ++ +E+ S+ ++ KE
Sbjct: 1149 EMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKEL 1208
Query: 333 INQFI---------------------EEIRQLDMDLEEHQD 352
F EE++ + L+EHQ+
Sbjct: 1209 QKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQE 1249
Score = 45.4 bits (106), Expect = 8e-05
Identities = 61/274 (22%), Positives = 130/274 (47%), Gaps = 29/274 (10%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVE--IKELQGQLADYNMLV- 157
LRS L E ++L++ N ++ EK+ E V +KE Q + +V
Sbjct: 1691 LRSVEETLKVERDQLKE-----NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVS 1745
Query: 158 DKLNTNTEMEEVMNDYN-MLKAQNDRETQSLDVI---FTERQAKEKQIRSVEEEIEQEKQ 213
+K N + M++ + N LKAQ+ + + L + E+Q ++R + E +
Sbjct: 1746 EKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLS 1805
Query: 214 ATDDIIKNMSFENQVKYLEMKTTNEKLL---QELDTLQQQL-DSQNMKKESLEAEIAHSQ 269
++N + + Q K E+K +L+ ++++ Q+++ + + +KK+ + + S+
Sbjct: 1806 NMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSK 1865
Query: 270 VKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDT 329
++ E + L +KL+E + E KS+ M+ER+ L + + E ++ L +T
Sbjct: 1866 LEIENLNLAQKLHE-------NLEEMKSV---MKERDNLRRVEETLKLERDQLKESLQET 1915
Query: 330 KEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEK 363
K + + +E++ M +EH++ + K+ EK
Sbjct: 1916 KARDLEIQQELKTARMLSKEHKETVD---KLREK 1946
Score = 45.1 bits (105), Expect = 1e-04
Identities = 50/210 (23%), Positives = 103/210 (49%), Gaps = 25/210 (11%)
Query: 145 ELQGQLADY-NMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRS 203
EL ADY N+++D TE EE+ LK + + + + ER+ K+ Q
Sbjct: 499 ELNSLRADYDNLVLDYEQLRTEKEEME-----LKLKEKNDLDEFEAL--ERKTKKDQEMQ 551
Query: 204 VEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDT---LQQQLDSQNMKKES 260
+ EI K +++K+ NQ E+ + E L ++ D LQ+ +DSQ K E+
Sbjct: 552 LIHEISNLK----NLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQ--KLEN 605
Query: 261 LEAEIAHS-QVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEI 319
++ ++++S + ++ + + L++ E+ +A D S E L ++K+ +E+
Sbjct: 606 IKMDLSYSLESIEDPKQMKQTLFDAET-----VALDAKRESAFLRSENL--ELKEKMKEL 658
Query: 320 ASMERQLTDTKEKINQFIEEIRQLDMDLEE 349
A+ +Q+ + + +E +++ +DLE+
Sbjct: 659 ATTYKQMENDIQLYQSQLEAKKKMQVDLEK 688
Score = 38.1 bits (87), Expect = 0.013
Identities = 46/262 (17%), Positives = 115/262 (43%), Gaps = 21/262 (8%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKE----LQGQLADYNMLVDK 159
++ +T E L++ + + E Y + E ++ KE L ++ +D+
Sbjct: 1194 EVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDE 1253
Query: 160 L--NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQA--KEKQIRSVEEEIEQEKQAT 215
L + + + +++N ++ K+ + + + V+ E++ K++ +E + + + T
Sbjct: 1254 LRRSVSEKTAQIINTQDLEKSHTKLQ-EEIPVLHEEQELLPNVKEVSETQETMNELELLT 1312
Query: 216 DDIIKNMSFENQVKYLEMKTTNEKLLQ---ELDTLQQQLDSQNMKKESLEAEIAHSQVKQ 272
+ S +E NEK + E+ +L ++ D+ KE+LE + H Q+K+
Sbjct: 1313 EQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALE--VKHDQLKE 1370
Query: 273 EAVLLHEKLYELESHRDQ---MIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDT 329
K+ E +S ++Q M +D + E E Q K + + +E ++
Sbjct: 1371 HIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEME----QFKPKDSALLRIEIEMLGL 1426
Query: 330 KEKINQFIEEIRQLDMDLEEHQ 351
+++ + +E++ + + ++ Q
Sbjct: 1427 SKRLQESHDEMKSVAKEKDDLQ 1448
Score = 33.5 bits (75), Expect = 0.32
Identities = 53/284 (18%), Positives = 117/284 (41%), Gaps = 49/284 (17%)
Query: 103 SKISELTTEV-----NKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLV 157
S+ ++LTTE N L + E + S + +K E I +LQ ++ + N +
Sbjct: 2373 SRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCL 2432
Query: 158 DKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDD 217
+K E +V+ D L A+ +E + ++ +++ V+ ++E+ K A +
Sbjct: 2433 EKTK---ETIQVLQDKVALGAKPYKE-----------EIEDLKMKLVKIDLEKMKNAKE- 2477
Query: 218 IIKNMSFENQVKYLEMKTTNEK----LLQELDTLQQQLDSQNMKKESLEAEIAHSQVK-- 271
FE ++ + +K LL+E QQ ++ E + + ++ +
Sbjct: 2478 ------FEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCG 2531
Query: 272 -QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTK 330
++ + K L+S ++ EK + ++K N+++ + +L
Sbjct: 2532 GGSGIVQNTKALILKSEHIRL--------------EKEISKLKQQNEQLIKQKNELLSNN 2577
Query: 331 EKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTG--SFKKQV 372
+ ++ ++ ++ + E H+ T K TG S KKQ+
Sbjct: 2578 QHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQI 2621
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 65.9 bits (159), Expect = 6e-11
Identities = 68/309 (22%), Positives = 137/309 (44%), Gaps = 42/309 (13%)
Query: 98 LGLLRSKISELTTEVNKL----QKGIE-MYNQENSVYLSYEKRAETLAVE----IKELQG 148
LG ++ +EL T++ K+ Q IE + NQ++S ++ K E L + IKE +
Sbjct: 603 LGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN 662
Query: 149 QLADYNMLVDKLNTN--TEMEEVMN----------DYNMLKAQNDRETQSLDVIFTERQA 196
L +DK EME+ +N + +L+A+ + +T+ +D ++ +A
Sbjct: 663 SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 722
Query: 197 KEKQI-------------RSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQ- 242
E+++ +S +++ Q+ +A + IK++ E + + + +L
Sbjct: 723 TEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGR 782
Query: 243 --ELDTLQQQLDSQNMKKESLEAEIA-----HSQVKQEAVLLHEKLYELESHRDQMIAED 295
+L LQ+ L + KE+LE E+ ++ +EAV + + E + Q +
Sbjct: 783 ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 842
Query: 296 KSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTN 355
+ S +E+ + L ++ +E E QL KEK+ I EI ++ D N
Sbjct: 843 NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMN 902
Query: 356 YGWKILEKN 364
++ E++
Sbjct: 903 DELRLKERD 911
Score = 49.3 bits (116), Expect = 6e-06
Identities = 67/296 (22%), Positives = 127/296 (42%), Gaps = 57/296 (19%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L+ K+++ + LQK IE + S ++ A+ E KEL+ +L+D ++
Sbjct: 915 LQLKLTKANENASFLQKSIE--DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKME-- 970
Query: 161 NTNTEMEEVMNDYNML----KAQNDRETQSLDVIFTERQAKEKQIRSVE----EEIEQEK 212
++ + +E+ Y K +++ Q+L + + K K R +E+E+ +
Sbjct: 971 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1030
Query: 213 QATDDIIKNMSFENQVKYLEMKT---------------TNEKLLQELDTLQQQ------- 250
+ D + E+ ++ +E T TN KL ELDTL++
Sbjct: 1031 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1090
Query: 251 -------LDSQNMKKESLEAEI-----AHSQVKQEAVLLHEK----LYELESHRD----- 289
L +N K E EI A +Q Q+ L E+ EL RD
Sbjct: 1091 LNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSH 1150
Query: 290 QMIAEDKSI--GSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQL 343
Q + E++S+ +E +++ K IKD ++E AS+++ ++ T + + E+ +L
Sbjct: 1151 QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL 1206
Score = 32.3 bits (72), Expect = 0.70
Identities = 34/162 (20%), Positives = 61/162 (37%), Gaps = 24/162 (14%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L ++ EV QK E + N+ L +KR + E + L + L
Sbjct: 1136 LAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1195
Query: 161 NT--NTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI 218
T + E+E++ N+ +L+ +N A K + SV + +E +K +
Sbjct: 1196 LTEKDAELEKLRNEVTVLRGEN---------------ASAKSLHSVVQTLESDKVKLELK 1240
Query: 219 IKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKES 260
+KN+ L++K +L Q D +ES
Sbjct: 1241 VKNLE-------LQLKENKRQLSSSSGNTDTQADEDERAQES 1275
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 65.9 bits (159), Expect = 6e-11
Identities = 68/309 (22%), Positives = 137/309 (44%), Gaps = 42/309 (13%)
Query: 98 LGLLRSKISELTTEVNKL----QKGIE-MYNQENSVYLSYEKRAETLAVE----IKELQG 148
LG ++ +EL T++ K+ Q IE + NQ++S ++ K E L + IKE +
Sbjct: 638 LGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN 697
Query: 149 QLADYNMLVDKLNTN--TEMEEVMN----------DYNMLKAQNDRETQSLDVIFTERQA 196
L +DK EME+ +N + +L+A+ + +T+ +D ++ +A
Sbjct: 698 SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 757
Query: 197 KEKQI-------------RSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQ- 242
E+++ +S +++ Q+ +A + IK++ E + + + +L
Sbjct: 758 TEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGR 817
Query: 243 --ELDTLQQQLDSQNMKKESLEAEIA-----HSQVKQEAVLLHEKLYELESHRDQMIAED 295
+L LQ+ L + KE+LE E+ ++ +EAV + + E + Q +
Sbjct: 818 ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 877
Query: 296 KSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTN 355
+ S +E+ + L ++ +E E QL KEK+ I EI ++ D N
Sbjct: 878 NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMN 937
Query: 356 YGWKILEKN 364
++ E++
Sbjct: 938 DELRLKERD 946
Score = 49.3 bits (116), Expect = 6e-06
Identities = 67/296 (22%), Positives = 127/296 (42%), Gaps = 57/296 (19%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L+ K+++ + LQK IE + S ++ A+ E KEL+ +L+D ++
Sbjct: 950 LQLKLTKANENASFLQKSIE--DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKME-- 1005
Query: 161 NTNTEMEEVMNDYNML----KAQNDRETQSLDVIFTERQAKEKQIRSVE----EEIEQEK 212
++ + +E+ Y K +++ Q+L + + K K R +E+E+ +
Sbjct: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
Query: 213 QATDDIIKNMSFENQVKYLEMKT---------------TNEKLLQELDTLQQQ------- 250
+ D + E+ ++ +E T TN KL ELDTL++
Sbjct: 1066 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1125
Query: 251 -------LDSQNMKKESLEAEI-----AHSQVKQEAVLLHEK----LYELESHRD----- 289
L +N K E EI A +Q Q+ L E+ EL RD
Sbjct: 1126 LNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSH 1185
Query: 290 QMIAEDKSI--GSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQL 343
Q + E++S+ +E +++ K IKD ++E AS+++ ++ T + + E+ +L
Sbjct: 1186 QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL 1241
Score = 32.3 bits (72), Expect = 0.70
Identities = 34/162 (20%), Positives = 61/162 (37%), Gaps = 24/162 (14%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L ++ EV QK E + N+ L +KR + E + L + L
Sbjct: 1171 LAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1230
Query: 161 NT--NTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI 218
T + E+E++ N+ +L+ +N A K + SV + +E +K +
Sbjct: 1231 LTEKDAELEKLRNEVTVLRGEN---------------ASAKSLHSVVQTLESDKVKLELK 1275
Query: 219 IKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKES 260
+KN+ L++K +L Q D +ES
Sbjct: 1276 VKNLE-------LQLKENKRQLSSSSGNTDTQADEDERAQES 1310
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 63.5 bits (153), Expect = 3e-10
Identities = 60/294 (20%), Positives = 135/294 (45%), Gaps = 45/294 (15%)
Query: 94 KSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQL--- 150
K L+ SK E+T ++N+LQK IE+ QE + E+ + L ++ + L+ Q+
Sbjct: 703 KDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEK 762
Query: 151 ------------ADYNMLVD---------KLNTNTEMEEVMNDYNMLKAQNDRET--QSL 187
A+ ++L D K++T EE + + +K+++ + +
Sbjct: 763 ENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEI 822
Query: 188 DVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTL 247
+++ E + ++Q + EEIE+++ KN +V Y E++ LL+ D L
Sbjct: 823 EILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNF----EVNYQELQEEYACLLKVKDDL 878
Query: 248 QQQLDSQNM----KKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPME 303
+ + Q + K ++L E+ ++ V + +++ + +AE +G +E
Sbjct: 879 EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK---TFVAETLEMGEVVE 935
Query: 304 -EREKLLKQIKDDNQEIASMERQLTDTKEKINQ-------FIEEIRQLDMDLEE 349
+ +L+++++ +E + ++L+D E++ Q EE++ L + E+
Sbjct: 936 KDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQ 989
Score = 60.5 bits (145), Expect = 2e-09
Identities = 64/283 (22%), Positives = 132/283 (46%), Gaps = 53/283 (18%)
Query: 93 DKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLAD 152
D +L ++ S+++ E+ +L + +E + ++Y +++E + +
Sbjct: 152 DSPTHLEMMESELAGKQHEIEELNRELE------EMRVTYGTEG---LQQLQEFEAAIKQ 202
Query: 153 YNMLVDKLNTNT-----EMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKE--------- 198
+ ++ +L N E +E M ++ L Q+ Q L + F + QA E
Sbjct: 203 RDGIITQLTANLQQARREKDETMREFLELTEQS----QKLQIQFQQLQASETLRNSTHSS 258
Query: 199 ---------KQIRSVEEEIEQEKQATDDIIKNMS-FENQVKYLEMKTTNEKLLQELDTLQ 248
+QI + ++++E++ +D K F Q+ +L+ K ++ Q+
Sbjct: 259 TAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD----- 313
Query: 249 QQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKL 308
+++++ N K+E E E ++ + + +K EL +D++ DK +G +L
Sbjct: 314 KKVENSN-KEEIQEKETIIEELNTKIIEEEKKTLEL---KDKLTTADKLLG-------EL 362
Query: 309 LKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ 351
+QI NQEI +M+ +LT++K+K Q EEI+QL +EE Q
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQ 405
Score = 59.3 bits (142), Expect = 5e-09
Identities = 63/296 (21%), Positives = 139/296 (46%), Gaps = 26/296 (8%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVE--IKE 145
Q+Q+ ++ + L + K + T +++ LQ+ I++Y E + + E E I+E
Sbjct: 274 QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEE 333
Query: 146 LQGQLADYNM----LVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT-----ERQA 196
L ++ + L DKL T ++++ + Q ++E +++ + T ERQ+
Sbjct: 334 LNTKIIEEEKKTLELKDKLTT---ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQS 390
Query: 197 KE--KQIRSVEEEIEQ----EKQATDDIIKNMSFENQVKYLEMKTTNEKLL-QELDTLQQ 249
E KQ+ EE+++ + Q DI++ M E Q K +++ +++ Q++ ++Q
Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQ 450
Query: 250 QLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEE----R 305
+L Q+M + E + H + A+ + + E M + +++ +
Sbjct: 451 ELIRQHMAQME-EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK 509
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKIL 361
EKL +++ +E +++RQL D E+++ E+I++ + E + N K L
Sbjct: 510 EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL 565
Score = 52.8 bits (125), Expect = 5e-07
Identities = 58/278 (20%), Positives = 122/278 (43%), Gaps = 30/278 (10%)
Query: 107 ELTTEVNKLQKG-IEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTE 165
+L E KL K +E+ Q V +K+ + L ++++E + + NTE
Sbjct: 1993 QLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ-----EKNTE 2047
Query: 166 MEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDII-----K 220
+ ++ L+ Q ++ + LD +R+ + + +++EQ+ + +
Sbjct: 2048 LMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQ 2107
Query: 221 NMSFENQVKYLEMKTTN-EKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHE 279
E +L+ KT +LL + LQ+ + +N + E LE + + +A+L+
Sbjct: 2108 TREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE---QALLVSA 2164
Query: 280 KLYELESHRDQMIAEDKSIGSPMEEREKLLK-QIKDDNQEIASMERQLTDTKEKINQF-- 336
+ Q + + K G+ + E L+ Q++ + I E+++T+ +E++ QF
Sbjct: 2165 DTF-------QKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
Query: 337 -----IEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFK 369
EE++QL M LE + + + LE+ FK
Sbjct: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2255
Score = 49.3 bits (116), Expect = 6e-06
Identities = 56/269 (20%), Positives = 116/269 (43%), Gaps = 47/269 (17%)
Query: 102 RSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLN 161
R I E+ L++ +E + +E E E+++L QL + K
Sbjct: 2195 RDAIDRKEKEITNLEEQLEQFREE----------LENKNEEVQQLHMQLE-----IQKKE 2239
Query: 162 TNTEMEEVMNDYNMLKAQNDR-----------ETQSLDVIFTER----QAKEKQIRSVEE 206
+ T ++E+ + + K ++ TQ V+F + Q KE +I + E
Sbjct: 2240 STTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNE 2299
Query: 207 EIEQEKQATDDIIKNMSFENQVKYL-EMKTTNEKLLQELDTL----QQQLDSQNMKKESL 261
++ + +Q N E + + + +++T E L+ + + + +++++ N E L
Sbjct: 2300 QVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKL 2359
Query: 262 EAEIAH--SQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEI 319
+ E+A+ + A L E+ L+ D +IAE + L +Q++ N+E+
Sbjct: 2360 QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA----------LEQQVETANEEM 2409
Query: 320 ASMERQLTDTKEKINQFIEEIRQLDMDLE 348
M+ L +T K+NQ +E+ L + E
Sbjct: 2410 TFMKNVLKETNFKMNQLTQELFSLKRERE 2438
Score = 47.0 bits (110), Expect = 3e-05
Identities = 65/281 (23%), Positives = 124/281 (44%), Gaps = 43/281 (15%)
Query: 103 SKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLA----VEIKELQGQLADYNMLVD 158
S + +L T++ +LQ+ E+Y+ S + R E L V ++E LA + +
Sbjct: 2992 SSLKDLITKM-QLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELT 3050
Query: 159 KLNTNTEMEEVMNDYNMLKAQNDRETQSL---------DVIFTERQAKEKQIR----SVE 205
L T T+ ++N + E Q+ + +E QA Q+ +++
Sbjct: 3051 ALGT-TDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLK 3109
Query: 206 EEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEI 265
E E EK + + + N+ + Q + LEM+ + LQ+QL S+ M L++E+
Sbjct: 3110 REQESEKPSQELLEYNIQ-QKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 3168
Query: 266 AHSQVKQEAVL--LHEKLYELESHR--------------DQMIAEDKSIGSPM----EER 305
A ++++ E L H+ L ELE+ R D + +E K +E+
Sbjct: 3169 AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEK 3228
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEK---INQFIEEIRQL 343
KL + + D +E+ ++ L K++ +N +E+ +QL
Sbjct: 3229 AKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQL 3269
Score = 45.4 bits (106), Expect = 8e-05
Identities = 62/311 (19%), Positives = 138/311 (44%), Gaps = 32/311 (10%)
Query: 61 LSSQIKVAHRPVTQQGLT-GMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQ-KG 118
L S+I+ H + + +T + ++ P +++L+ Y + +S++ E+ E++ ++ +
Sbjct: 3090 LLSEIQALHAQMNGRKITLKREQESEKPSQELLE--YNIQQKQSQMLEMQVELSSMKDRA 3147
Query: 119 IEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNT-------NTEMEEVMN 171
E+ Q +S + + LA EL+ L + + +L T+ ++N
Sbjct: 3148 TELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLN 3207
Query: 172 DYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYL 231
D + + RE Q A EK+ + E++K+ +D+ ++ + Q + L
Sbjct: 3208 DTLASEQKKSRELQ---------WALEKEKAKLGRSEERDKEELEDLKFSLESQKQ-RNL 3257
Query: 232 EMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKL---------- 281
++ E+ Q L+ QQ+++SQ M ++ +E ++ + +L EK+
Sbjct: 3258 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3317
Query: 282 YELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN-QFIEEI 340
E E H ++ P E LLK+++ +E S +L + EK ++
Sbjct: 3318 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR 3377
Query: 341 RQLDMDLEEHQ 351
+Q++ D + H+
Sbjct: 3378 QQMEKDRQVHR 3388
Score = 40.8 bits (94), Expect = 0.002
Identities = 47/219 (21%), Positives = 98/219 (44%), Gaps = 15/219 (6%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT 192
EK A L +I +L+ + +Y T + E N N+ + + D + +
Sbjct: 2549 EKVAAALVSQI-QLEA-VQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTL 2606
Query: 193 ERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTT---NEKLLQELDTLQQ 249
E Q+ + + EK+ + KN+ E + K LE++ NEK +E + +
Sbjct: 2607 RISELESQVVEMHTSLILEKEQVEIAEKNV-LEKEKKLLELQKLLEGNEKKQREKEKKRS 2665
Query: 250 QLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLL 309
D + +K + E+ HS +E+ +E LE+ R + +A + S E+ EKL
Sbjct: 2666 PQDVEVLKTTT---ELFHSN--EESGFFNE----LEALRAESVATKAELASYKEKAEKLQ 2716
Query: 310 KQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLE 348
+++ + S+++ L+ ++ + + E++ L+ + E
Sbjct: 2717 EELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDE 2755
Score = 40.0 bits (92), Expect = 0.003
Identities = 48/247 (19%), Positives = 112/247 (45%), Gaps = 28/247 (11%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIK-ELQGQLADYNMLVDKLNT 162
K+ +L E++++ G ++ + + + + E + K E++ L Y+ + +
Sbjct: 429 KLEQLRAELDEMY-GQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQ 487
Query: 163 NTEMEEVMNDYNM----LKAQNDRETQSLDVIFTERQAKEKQIRSVEEEI----EQEKQA 214
M +N+ N+ +Q ++ + L +I E+ A ++Q+ + EE+ EQ ++A
Sbjct: 488 IKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRA 547
Query: 215 TDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEA 274
I + S N+ K L ++ L+ ++ S + ++ LE +K EA
Sbjct: 548 RQTIAEQESKLNEA---------HKSLSTVEDLKAEIVSASESRKELE-------LKHEA 591
Query: 275 VLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN 334
+ + K+ +++ D+ S E E+L Q+ ++E S ++ + + +IN
Sbjct: 592 EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRIN 651
Query: 335 QFIEEIR 341
IE+++
Sbjct: 652 --IEKLK 656
Score = 37.7 bits (86), Expect = 0.017
Identities = 43/223 (19%), Positives = 97/223 (43%), Gaps = 34/223 (15%)
Query: 130 LSYEKRA-ETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLD 188
L E RA E LAVE+ + +G + Y ++ + + Q +T +D
Sbjct: 1903 LHEESRAREQLAVELSKAEGVIDGY----------------ADEKTLFERQIQEKTDIID 1946
Query: 189 VIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQ 248
+ E ++ +E+E E+Q + + +S + + E ++LLQE + L
Sbjct: 1947 RLEQELLCASNRL----QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLM 2002
Query: 249 QQLDSQNMKKESLEAEIAHSQVKQEAVLLHE---KLYELESHRDQMIAEDKSIGSPMEER 305
++ + E + ++ QVK + + E + ELE ++ + + + +E++
Sbjct: 2003 KEKLEVQCQAEKVRDDL-QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ 2061
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLE 348
+ +++ D+ Q D + + + F +EI++L+ L+
Sbjct: 2062 LEKMRKFLDE---------QAIDREHERDVFQQEIQKLEQQLK 2095
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 63.5 bits (153), Expect = 3e-10
Identities = 60/294 (20%), Positives = 135/294 (45%), Gaps = 45/294 (15%)
Query: 94 KSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQL--- 150
K L+ SK E+T ++N+LQK IE+ QE + E+ + L ++ + L+ Q+
Sbjct: 703 KDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEK 762
Query: 151 ------------ADYNMLVD---------KLNTNTEMEEVMNDYNMLKAQNDRET--QSL 187
A+ ++L D K++T EE + + +K+++ + +
Sbjct: 763 ENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEI 822
Query: 188 DVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTL 247
+++ E + ++Q + EEIE+++ KN +V Y E++ LL+ D L
Sbjct: 823 EILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNF----EVNYQELQEEYACLLKVKDDL 878
Query: 248 QQQLDSQNM----KKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPME 303
+ + Q + K ++L E+ ++ V + +++ + +AE +G +E
Sbjct: 879 EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK---TFVAETLEMGEVVE 935
Query: 304 -EREKLLKQIKDDNQEIASMERQLTDTKEKINQ-------FIEEIRQLDMDLEE 349
+ +L+++++ +E + ++L+D E++ Q EE++ L + E+
Sbjct: 936 KDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQ 989
Score = 60.5 bits (145), Expect = 2e-09
Identities = 64/283 (22%), Positives = 132/283 (46%), Gaps = 53/283 (18%)
Query: 93 DKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLAD 152
D +L ++ S+++ E+ +L + +E + ++Y +++E + +
Sbjct: 152 DSPTHLEMMESELAGKQHEIEELNRELE------EMRVTYGTEG---LQQLQEFEAAIKQ 202
Query: 153 YNMLVDKLNTNT-----EMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKE--------- 198
+ ++ +L N E +E M ++ L Q+ Q L + F + QA E
Sbjct: 203 RDGIITQLTANLQQARREKDETMREFLELTEQS----QKLQIQFQQLQASETLRNSTHSS 258
Query: 199 ---------KQIRSVEEEIEQEKQATDDIIKNMS-FENQVKYLEMKTTNEKLLQELDTLQ 248
+QI + ++++E++ +D K F Q+ +L+ K ++ Q+
Sbjct: 259 TAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD----- 313
Query: 249 QQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKL 308
+++++ N K+E E E ++ + + +K EL +D++ DK +G +L
Sbjct: 314 KKVENSN-KEEIQEKETIIEELNTKIIEEEKKTLEL---KDKLTTADKLLG-------EL 362
Query: 309 LKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ 351
+QI NQEI +M+ +LT++K+K Q EEI+QL +EE Q
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQ 405
Score = 59.3 bits (142), Expect = 5e-09
Identities = 63/296 (21%), Positives = 139/296 (46%), Gaps = 26/296 (8%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVE--IKE 145
Q+Q+ ++ + L + K + T +++ LQ+ I++Y E + + E E I+E
Sbjct: 274 QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEE 333
Query: 146 LQGQLADYNM----LVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT-----ERQA 196
L ++ + L DKL T ++++ + Q ++E +++ + T ERQ+
Sbjct: 334 LNTKIIEEEKKTLELKDKLTT---ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQS 390
Query: 197 KE--KQIRSVEEEIEQ----EKQATDDIIKNMSFENQVKYLEMKTTNEKLL-QELDTLQQ 249
E KQ+ EE+++ + Q DI++ M E Q K +++ +++ Q++ ++Q
Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQ 450
Query: 250 QLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEE----R 305
+L Q+M + E + H + A+ + + E M + +++ +
Sbjct: 451 ELIRQHMAQME-EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK 509
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKIL 361
EKL +++ +E +++RQL D E+++ E+I++ + E + N K L
Sbjct: 510 EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL 565
Score = 53.9 bits (128), Expect = 2e-07
Identities = 49/257 (19%), Positives = 116/257 (45%), Gaps = 29/257 (11%)
Query: 107 ELTTEVNKLQKG-IEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTE 165
+L E KL K +E+ Q V +K+ + L ++++E + + NTE
Sbjct: 1993 QLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ-----EKNTE 2047
Query: 166 MEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDII-----K 220
+ ++ L+ Q ++ + LD +R+ + + +++EQ+ + +
Sbjct: 2048 LMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQ 2107
Query: 221 NMSFENQVKYLEMKTTN-EKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHE 279
E +L+ KT +LL + LQ+ + +N + E LE + + +A+L+ +
Sbjct: 2108 TREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE---QALLVED 2164
Query: 280 KLY--------------ELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQ 325
+ + +L++ RD + ++K I + E+ E+ +++++ N+E+ + Q
Sbjct: 2165 RKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2224
Query: 326 LTDTKEKINQFIEEIRQ 342
L K++ ++E+ Q
Sbjct: 2225 LEIQKKESTTRLQELEQ 2241
Score = 53.1 bits (126), Expect = 4e-07
Identities = 67/322 (20%), Positives = 141/322 (43%), Gaps = 49/322 (15%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
+RQI +K+ + L ++ + + +L+ + +E + LS +K A E Q
Sbjct: 1935 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL-LSRQKEAMKAEAGPVEQQ 1993
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYN----------------MLKAQNDRETQSLDVIF 191
++ +KL + E+V +D ++ + ++ T+ +D +
Sbjct: 1994 LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD-LR 2052
Query: 192 TERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTT--------NEKLLQE 243
+ QA EKQ+ + + +++ QA D + F+ +++ LE + +E +E
Sbjct: 2053 QQNQALEKQLEKMRKFLDE--QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
Query: 244 LDTLQQQLDSQNMK-------KESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDK 296
++ L L + K KE L+ +I + +E L ++ ELE ++ ED+
Sbjct: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDI--QERNEEIEKLEFRVRELEQ---ALLVEDR 2165
Query: 297 SIGSPMEEREKLLK--QIKDDNQEIASMERQLTDTKEKINQF-------IEEIRQLDMDL 347
+E + +L Q++ + I E+++T+ +E++ QF EE++QL M L
Sbjct: 2166 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 2225
Query: 348 EEHQDPTNYGWKILEKNTGSFK 369
E + + + LE+ FK
Sbjct: 2226 EIQKKESTTRLQELEQENKLFK 2247
Score = 49.7 bits (117), Expect = 4e-06
Identities = 58/285 (20%), Positives = 130/285 (45%), Gaps = 36/285 (12%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
Q +++ + G + +K EL+ EV +LQ + +++ + E++ E E++
Sbjct: 2158 QALLVEDRKHFGAVEAK-PELSLEV-QLQAERDAIDRKEKEITNLEEQLEQFREELENKN 2215
Query: 148 GQLADYNMLVD--KLNTNTEMEEVMNDYNMLKAQNDR-----------ETQSLDVIFTER 194
++ +M ++ K + T ++E+ + + K ++ TQ V+F +
Sbjct: 2216 EEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKF 2275
Query: 195 ----QAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYL-EMKTTNEKLLQELDTL-- 247
Q KE +I + E++ + +Q N E + + + +++T E L+ + + +
Sbjct: 2276 AQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKR 2335
Query: 248 --QQQLDSQNMKKESLEAEIAH--SQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPME 303
+++++ N E L+ E+A+ + A L E+ L+ D +IAE +
Sbjct: 2336 NREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA------ 2389
Query: 304 EREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLE 348
L +Q++ N+E+ M+ L +T K+NQ +E+ L + E
Sbjct: 2390 ----LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE 2430
Score = 47.0 bits (110), Expect = 3e-05
Identities = 65/281 (23%), Positives = 124/281 (44%), Gaps = 43/281 (15%)
Query: 103 SKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLA----VEIKELQGQLADYNMLVD 158
S + +L T++ +LQ+ E+Y+ S + R E L V ++E LA + +
Sbjct: 2984 SSLKDLITKM-QLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELT 3042
Query: 159 KLNTNTEMEEVMNDYNMLKAQNDRETQSL---------DVIFTERQAKEKQIR----SVE 205
L T T+ ++N + E Q+ + +E QA Q+ +++
Sbjct: 3043 ALGT-TDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLK 3101
Query: 206 EEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEI 265
E E EK + + + N+ + Q + LEM+ + LQ+QL S+ M L++E+
Sbjct: 3102 REQESEKPSQELLEYNIQ-QKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 3160
Query: 266 AHSQVKQEAVL--LHEKLYELESHR--------------DQMIAEDKSIGSPM----EER 305
A ++++ E L H+ L ELE+ R D + +E K +E+
Sbjct: 3161 AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEK 3220
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEK---INQFIEEIRQL 343
KL + + D +E+ ++ L K++ +N +E+ +QL
Sbjct: 3221 AKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQL 3261
Score = 45.4 bits (106), Expect = 8e-05
Identities = 62/311 (19%), Positives = 138/311 (44%), Gaps = 32/311 (10%)
Query: 61 LSSQIKVAHRPVTQQGLT-GMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQ-KG 118
L S+I+ H + + +T + ++ P +++L+ Y + +S++ E+ E++ ++ +
Sbjct: 3082 LLSEIQALHAQMNGRKITLKREQESEKPSQELLE--YNIQQKQSQMLEMQVELSSMKDRA 3139
Query: 119 IEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNT-------NTEMEEVMN 171
E+ Q +S + + LA EL+ L + + +L T+ ++N
Sbjct: 3140 TELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLN 3199
Query: 172 DYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYL 231
D + + RE Q A EK+ + E++K+ +D+ ++ + Q + L
Sbjct: 3200 DTLASEQKKSRELQ---------WALEKEKAKLGRSEERDKEELEDLKFSLESQKQ-RNL 3249
Query: 232 EMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKL---------- 281
++ E+ Q L+ QQ+++SQ M ++ +E ++ + +L EK+
Sbjct: 3250 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3309
Query: 282 YELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN-QFIEEI 340
E E H ++ P E LLK+++ +E S +L + EK ++
Sbjct: 3310 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR 3369
Query: 341 RQLDMDLEEHQ 351
+Q++ D + H+
Sbjct: 3370 QQMEKDRQVHR 3380
Score = 40.8 bits (94), Expect = 0.002
Identities = 47/219 (21%), Positives = 98/219 (44%), Gaps = 15/219 (6%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT 192
EK A L +I +L+ + +Y T + E N N+ + + D + +
Sbjct: 2541 EKVAAALVSQI-QLEA-VQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTL 2598
Query: 193 ERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTT---NEKLLQELDTLQQ 249
E Q+ + + EK+ + KN+ E + K LE++ NEK +E + +
Sbjct: 2599 RISELESQVVEMHTSLILEKEQVEIAEKNV-LEKEKKLLELQKLLEGNEKKQREKEKKRS 2657
Query: 250 QLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLL 309
D + +K + E+ HS +E+ +E LE+ R + +A + S E+ EKL
Sbjct: 2658 PQDVEVLKTTT---ELFHSN--EESGFFNE----LEALRAESVATKAELASYKEKAEKLQ 2708
Query: 310 KQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLE 348
+++ + S+++ L+ ++ + + E++ L+ + E
Sbjct: 2709 EELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDE 2747
Score = 40.0 bits (92), Expect = 0.003
Identities = 48/247 (19%), Positives = 112/247 (45%), Gaps = 28/247 (11%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIK-ELQGQLADYNMLVDKLNT 162
K+ +L E++++ G ++ + + + + E + K E++ L Y+ + +
Sbjct: 429 KLEQLRAELDEMY-GQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQ 487
Query: 163 NTEMEEVMNDYNM----LKAQNDRETQSLDVIFTERQAKEKQIRSVEEEI----EQEKQA 214
M +N+ N+ +Q ++ + L +I E+ A ++Q+ + EE+ EQ ++A
Sbjct: 488 IKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRA 547
Query: 215 TDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEA 274
I + S N+ K L ++ L+ ++ S + ++ LE +K EA
Sbjct: 548 RQTIAEQESKLNEA---------HKSLSTVEDLKAEIVSASESRKELE-------LKHEA 591
Query: 275 VLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN 334
+ + K+ +++ D+ S E E+L Q+ ++E S ++ + + +IN
Sbjct: 592 EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRIN 651
Query: 335 QFIEEIR 341
IE+++
Sbjct: 652 --IEKLK 656
Score = 31.6 bits (70), Expect = 1.2
Identities = 29/122 (23%), Positives = 53/122 (43%), Gaps = 13/122 (10%)
Query: 238 EKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVL-------LHEKLYELESHRDQ 290
EKLL+ + QL+ + + L E KQEA L E+L+E R+Q
Sbjct: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQ--KQEATESLKCQEELRERLHEESRAREQ 1912
Query: 291 MIAE----DKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMD 346
+ E + I +E+ +QI++ I +E++L ++ + E +Q+ +
Sbjct: 1913 LAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE 1972
Query: 347 LE 348
E
Sbjct: 1973 RE 1974
>gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]
Length = 1217
Score = 62.0 bits (149), Expect = 8e-10
Identities = 69/268 (25%), Positives = 123/268 (45%), Gaps = 30/268 (11%)
Query: 102 RSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEI--KELQGQLADYNMLVDK 159
R KI+EL + + +E +E + Y ++K L I +EL A + L K
Sbjct: 186 REKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAK 245
Query: 160 LNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKE--KQIRSVEEEIEQEKQATDD 217
T+ E + D AQ D + D+ ERQ +E +I +++EE EQ +
Sbjct: 246 RETSGEKSRQLRD-----AQQDARDKMEDI---ERQVRELKTKISAMKEEKEQLSAERQE 297
Query: 218 IIKNMS-FENQVKYLEMKTTN-----EKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK 271
IK + E + K L+ + ++LL+E L ++++ + +KE E E + VK
Sbjct: 298 QIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEK--QKELAETEPKFNSVK 355
Query: 272 QEAVLLHEKLYELESHRDQMIAEDK--SIGSPMEEREKLLKQ--------IKDDNQEIAS 321
++ +L + R + A+ S + EER+K +K+ I D ++IA+
Sbjct: 356 EKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAA 415
Query: 322 MERQLTDTKEKINQFIEEIRQLDMDLEE 349
+ + L DT+ + +E+ +LD DL E
Sbjct: 416 IHKDLEDTEANKEKNLEQYNKLDQDLNE 443
Score = 51.2 bits (121), Expect = 1e-06
Identities = 54/260 (20%), Positives = 112/260 (43%), Gaps = 33/260 (12%)
Query: 130 LSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDV 189
L +K E+ EL+ +L + N+ + N E++++MN ++ Q + S D
Sbjct: 676 LELQKDVRKAEEELGELEAKLNE-NLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDS 734
Query: 190 IFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDT-LQ 248
I +E + +++ + E+ ++++ + ++ M++T E L EL T L
Sbjct: 735 ILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLH--------AMESTRESLKAELGTDLL 786
Query: 249 QQLDSQNMKK-ESLEAEIAHSQ----------VKQEAVLLHEKLYELESHRDQMIAEDKS 297
QL ++ K+ ++L EI Q +K E ++ + Y E+ R ++ ++
Sbjct: 787 SQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQE 846
Query: 298 IGSPME------------EREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDM 345
+ E E E + K++KD ++ + T+ I + + + +
Sbjct: 847 LNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKN 906
Query: 346 DLEEHQDPTNYGWKILEKNT 365
+EH D N+ K LEK T
Sbjct: 907 MEKEHMDAINHDTKELEKMT 926
Score = 47.4 bits (111), Expect = 2e-05
Identities = 48/238 (20%), Positives = 102/238 (42%), Gaps = 22/238 (9%)
Query: 153 YNMLVDKLNTNTEMEEVMNDYNMLKAQ-NDRETQSLDVIFTERQAKEKQIRSVEEEIEQE 211
Y+ +L ++ + + L+A+ N+ ++++ I E Q++ +E + +
Sbjct: 669 YDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKF 728
Query: 212 KQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK 271
K + D I+ M + + KT K + L +L+ L + +ESL+AE+ +
Sbjct: 729 KASRDSILSEMKMLKEKRQQSEKTFMPKQ-RSLQSLEASLHAMESTRESLKAELGTDLLS 787
Query: 272 QEAV-------LLHEKLYELESHRDQMIAEDKSIGSPM--------EEREKLLKQIKDDN 316
Q ++ L++++ +L+ Q++ E + + E K L Q++ +
Sbjct: 788 QLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQEL 847
Query: 317 QEIASME-----RQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFK 369
E+ E T E IN+ +++ DL+ D T G K L+K+ +K
Sbjct: 848 NELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWK 905
Score = 42.0 bits (97), Expect = 9e-04
Identities = 52/271 (19%), Positives = 114/271 (42%), Gaps = 48/271 (17%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLA--------- 151
+ ++ EL T+++ +++ E + E + K+ L ++ K+LQ +LA
Sbjct: 270 IERQVRELKTKISAMKEEKEQLSAERQEQI---KQRTKLELKAKDLQDELAGNSEQRKRL 326
Query: 152 --DYNMLVDKLNTNT-EMEEVMNDYNMLKAQNDRETQSLDVIFTER------QAKEKQIR 202
+ L++K+ E+ E +N +K + +R L ER Q + Q
Sbjct: 327 LKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFT 386
Query: 203 SVEEE---IEQEKQATDDIIKNMSFENQVKYLEMKTTN---EKLLQELDTLQQQLDSQNM 256
S EE I++E ++ D I + + + +++ T EK L++ + L Q L+
Sbjct: 387 SKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKA 446
Query: 257 KKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDN 316
+ E L+ K YE+++ +D++ +E + ++ L ++D
Sbjct: 447 RVEELD----------------RKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDL 490
Query: 317 QEIASMERQLTDTK-----EKINQFIEEIRQ 342
++ + R T + IN+ ++ R+
Sbjct: 491 EKKQQLLRAATGKAILNGIDSINKVLDHFRR 521
>gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1
[Homo sapiens]
Length = 1288
Score = 61.6 bits (148), Expect = 1e-09
Identities = 60/270 (22%), Positives = 132/270 (48%), Gaps = 31/270 (11%)
Query: 96 YYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNM 155
YY+ L+ +I+E+ T+ K+ + + N+++++ LS E +A+ V+ E
Sbjct: 325 YYIYELQKRIAEMETQKEKIHEDTKEINEKSNI-LSNEMKAKNKDVKDTE---------- 373
Query: 156 LVDKLNTNTE-MEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQA 214
KLN T+ +EE + L ++ + + L ++ + EKQ++ +E++E+ K
Sbjct: 374 --KKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSI 431
Query: 215 ---TDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEI-AHSQV 270
+++II + N E + +KL + +D+L+Q+ +KES E E+ S+
Sbjct: 432 PAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKS 491
Query: 271 KQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLL----KQIKDDNQEIASMERQL 326
EA K+ +S D ++ + S + + ++ L + +K+ I +E +L
Sbjct: 492 VNEA---RSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKL 548
Query: 327 TDTKEKINQFIEEIRQLDMDLEEHQDPTNY 356
T++++ + +E+++L Q+ TN+
Sbjct: 549 PQTEQELKEKEKELQKLT------QEETNF 572
Score = 38.9 bits (89), Expect = 0.008
Identities = 34/170 (20%), Positives = 79/170 (46%), Gaps = 12/170 (7%)
Query: 195 QAKEKQIRSVEEEIEQE-KQATDDIIKNMSFENQVKYL-----EMKTTNEKLLQELDTLQ 248
+ E+++ +E +++ + K+A + + E +V L EM+ T EK + L
Sbjct: 770 EISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLI 829
Query: 249 QQLDSQNMKKESLEAEI-AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREK 307
+Q + N++ + LEA + A + K++ LL E + ++ D + + + + ++
Sbjct: 830 EQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHN 889
Query: 308 LLKQI-----KDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQD 352
+ +I K ++ + +QL + I + I+ D +L++ QD
Sbjct: 890 TIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQD 939
Score = 32.3 bits (72), Expect = 0.70
Identities = 40/252 (15%), Positives = 102/252 (40%), Gaps = 28/252 (11%)
Query: 146 LQGQLADYNMLVDKLNTNTEMEEVMNDY-------NMLKAQNDRETQSLDVIFTERQAKE 198
LQG++ M+ K TE +E M +Y L + ++++ R K
Sbjct: 228 LQGEVEQIAMMKPK--GQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKL 285
Query: 199 KQIRSVEEEIEQEKQATDDIIKNMSFENQV-----------------KYLEMKTTNEKLL 241
+++ VE+E + + + I+ ++ EN++ + EM+T EK+
Sbjct: 286 NRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIH 345
Query: 242 QELDTLQQQLD--SQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIG 299
++ + ++ + S MK ++ + + ++ + + E + + + + +
Sbjct: 346 EDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLK 405
Query: 300 SPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWK 359
+ +KL KQ++ D +++ + + IN+ L+ + E+ +
Sbjct: 406 HATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMD 465
Query: 360 ILEKNTGSFKKQ 371
L++ T +K+
Sbjct: 466 SLKQETQGLQKE 477
>gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1
[Homo sapiens]
Length = 1288
Score = 61.6 bits (148), Expect = 1e-09
Identities = 60/270 (22%), Positives = 132/270 (48%), Gaps = 31/270 (11%)
Query: 96 YYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNM 155
YY+ L+ +I+E+ T+ K+ + + N+++++ LS E +A+ V+ E
Sbjct: 325 YYIYELQKRIAEMETQKEKIHEDTKEINEKSNI-LSNEMKAKNKDVKDTE---------- 373
Query: 156 LVDKLNTNTE-MEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQA 214
KLN T+ +EE + L ++ + + L ++ + EKQ++ +E++E+ K
Sbjct: 374 --KKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSI 431
Query: 215 ---TDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEI-AHSQV 270
+++II + N E + +KL + +D+L+Q+ +KES E E+ S+
Sbjct: 432 PAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKS 491
Query: 271 KQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLL----KQIKDDNQEIASMERQL 326
EA K+ +S D ++ + S + + ++ L + +K+ I +E +L
Sbjct: 492 VNEA---RSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKL 548
Query: 327 TDTKEKINQFIEEIRQLDMDLEEHQDPTNY 356
T++++ + +E+++L Q+ TN+
Sbjct: 549 PQTEQELKEKEKELQKLT------QEETNF 572
Score = 38.9 bits (89), Expect = 0.008
Identities = 34/170 (20%), Positives = 79/170 (46%), Gaps = 12/170 (7%)
Query: 195 QAKEKQIRSVEEEIEQE-KQATDDIIKNMSFENQVKYL-----EMKTTNEKLLQELDTLQ 248
+ E+++ +E +++ + K+A + + E +V L EM+ T EK + L
Sbjct: 770 EISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLI 829
Query: 249 QQLDSQNMKKESLEAEI-AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREK 307
+Q + N++ + LEA + A + K++ LL E + ++ D + + + + ++
Sbjct: 830 EQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHN 889
Query: 308 LLKQI-----KDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQD 352
+ +I K ++ + +QL + I + I+ D +L++ QD
Sbjct: 890 TIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQD 939
Score = 32.3 bits (72), Expect = 0.70
Identities = 40/252 (15%), Positives = 102/252 (40%), Gaps = 28/252 (11%)
Query: 146 LQGQLADYNMLVDKLNTNTEMEEVMNDY-------NMLKAQNDRETQSLDVIFTERQAKE 198
LQG++ M+ K TE +E M +Y L + ++++ R K
Sbjct: 228 LQGEVEQIAMMKPK--GQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKL 285
Query: 199 KQIRSVEEEIEQEKQATDDIIKNMSFENQV-----------------KYLEMKTTNEKLL 241
+++ VE+E + + + I+ ++ EN++ + EM+T EK+
Sbjct: 286 NRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIH 345
Query: 242 QELDTLQQQLD--SQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIG 299
++ + ++ + S MK ++ + + ++ + + E + + + + +
Sbjct: 346 EDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLK 405
Query: 300 SPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWK 359
+ +KL KQ++ D +++ + + IN+ L+ + E+ +
Sbjct: 406 HATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMD 465
Query: 360 ILEKNTGSFKKQ 371
L++ T +K+
Sbjct: 466 SLKQETQGLQKE 477
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 61.2 bits (147), Expect = 1e-09
Identities = 74/314 (23%), Positives = 135/314 (42%), Gaps = 62/314 (19%)
Query: 106 SELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVD-----KL 160
+EL +V KLQ +E+ N + S + ++ L + L+ QL D L+ KL
Sbjct: 1269 TELADKVTKLQ--VELDNVTGLLSQS-DSKSSKLTKDFSALESQLQDTQELLQEENRQKL 1325
Query: 161 NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIK 220
+ +T++++V ++ N + Q + E ++ + EKQI ++ ++ K+ +D +
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEA-------KHNLEKQIATLHAQVADMKKKMEDSVG 1378
Query: 221 NMSFENQVK--------------------YLEMKTTNEKLLQELDTLQQQLDSQNMKKES 260
+ +VK Y +++ T +L QELD L LD Q +
Sbjct: 1379 CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438
Query: 261 LEAEIAHSQVKQEAVLLHEKL----YELESHRDQMIAEDK-----SIGSPMEER------ 305
LE + Q K + +L EK Y E R + A +K S+ +EE
Sbjct: 1439 LEKK----QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE 1494
Query: 306 -EKLLKQIKDDNQEIASME-------RQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYG 357
E+L KQ + + +++ S + +L +K + Q +EE++ +LE+ T
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDA 1554
Query: 358 WKILEKNTGSFKKQ 371
LE N + K Q
Sbjct: 1555 KLRLEVNLQAMKAQ 1568
Score = 58.2 bits (139), Expect = 1e-08
Identities = 74/325 (22%), Positives = 152/325 (46%), Gaps = 55/325 (16%)
Query: 74 QQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYE 133
QQ LT MK + + +++ L +K+ L +V++ ++ EM +E + E
Sbjct: 803 QQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLL-QVSRQEE--EMMAKEEELVKVRE 859
Query: 134 KR--AETLAVEIKELQGQL-ADYNMLVDKLNTNTEM------------------EEVMND 172
K+ AE E++ LQ QL A+ L ++L TE+ EE+ +D
Sbjct: 860 KQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHD 919
Query: 173 YNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI-IKNMSFENQVKYL 231
L+A+ + E + + E++ ++ I+ +EE++E+E+ A + ++ ++ E ++K L
Sbjct: 920 ---LEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKL 976
Query: 232 E-----MKTTNEKLLQELDTLQQQL---DSQNMKKESLEAEIAHSQVKQEAVL--LHEKL 281
E ++ N KL +E L+ ++ + ++E +A + K EA++ L E+L
Sbjct: 977 EEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERL 1036
Query: 282 YELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKI-------- 333
E R ++ +K+ + L QI + +IA ++ QL +E++
Sbjct: 1037 RREEKQRQEL---EKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVE 1093
Query: 334 ------NQFIEEIRQLDMDLEEHQD 352
N +++IR+L+ + E Q+
Sbjct: 1094 EEAAQKNMALKKIRELESQISELQE 1118
Score = 57.4 bits (137), Expect = 2e-08
Identities = 59/247 (23%), Positives = 116/247 (46%), Gaps = 40/247 (16%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT 192
E +A +LA ++E Q A+ L + T EME++M+ D +S+ +
Sbjct: 1475 ETKALSLARALEEAMEQKAELERLNKQFRT--EMEDLMSS-------KDDVGKSVHELEK 1525
Query: 193 ERQAKEKQIRSVE---EEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQ 249
++A E+Q+ ++ EE+E E QAT+D + +V MK E+ LQ D +
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRL----EVNLQAMKAQFERDLQGRDEQSE 1581
Query: 250 QLDSQNMKK-ESLEAEIAHSQVKQEAVLLHEK-----LYELESH-------RDQMIAEDK 296
+ Q +++ +EAE+ + ++ + K L +LE+H RD+ I + +
Sbjct: 1582 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641
Query: 297 SIGSPMEE-----------REKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDM 345
+ + M++ RE++L Q K++ +++ SME ++ +E++ RQ
Sbjct: 1642 KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQ 1701
Query: 346 DLEEHQD 352
+ +E D
Sbjct: 1702 ERDELAD 1708
Score = 56.6 bits (135), Expect = 3e-08
Identities = 61/270 (22%), Positives = 115/270 (42%), Gaps = 22/270 (8%)
Query: 93 DKSYYLGLLRSKISELTTEVNKLQKGIEMYNQE-NSVYLSYEKRAETLAVEIKELQGQLA 151
+KS L L++K + T++ + + E QE E + L+ +I ELQ Q+A
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIA 1072
Query: 152 DYNMLVDKLNTNTE-----MEEVMNDYNM-------LKAQNDRETQSLDVIFTERQAKEK 199
+ M + K + +EE NM L++Q + L+ R EK
Sbjct: 1073 ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEK 1132
Query: 200 QIRSVEEEIEQEKQATDDIIKNMSFENQV---KYLEMKTTNEKLLQELDTLQQQLDSQNM 256
Q R + EE+E K +D + + + + ++ + E+ + L +E T + Q+
Sbjct: 1133 QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQ 1192
Query: 257 KKESLEAEIAH--SQVKQEAVLLHEKLYELESHRDQMIAEDKSI----GSPMEEREKLLK 310
K E+A Q K+ L + LE+ R ++ E K + G +R+K+
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEA 1252
Query: 311 QIKDDNQEIASMERQLTDTKEKINQFIEEI 340
Q+++ + ER T+ +K+ + E+
Sbjct: 1253 QLQELQVKFNEGERVRTELADKVTKLQVEL 1282
Score = 48.9 bits (115), Expect = 7e-06
Identities = 51/226 (22%), Positives = 104/226 (46%), Gaps = 19/226 (8%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT 192
EK+ +++ E+ +LQ +LA K E +E+ ++ + + + +L+
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERA--KRQAQQERDELADE---IANSSGKGALALE---- 1722
Query: 193 ERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFEN-QVKYLEMKTTNEKL-LQELDTLQQQ 250
E++ E +I +EEE+E+E+ T+ I + N Q+ + E+ Q+ + +QQ
Sbjct: 1723 EKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ 1782
Query: 251 LDSQN----MKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEERE 306
L+ QN +K + +E + S+ K L K+ +LE D E ++ + E
Sbjct: 1783 LERQNKELKVKLQEMEGTVK-SKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE 1841
Query: 307 KLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQD 352
K LK + ++ R K++ ++ ++QL LEE ++
Sbjct: 1842 KKLKDVL---LQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEE 1884
Score = 45.1 bits (105), Expect = 1e-04
Identities = 43/233 (18%), Positives = 102/233 (43%), Gaps = 13/233 (5%)
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFT 192
E++ + L +++E++ +L D + +++ D L+A D ++ D
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERK--QRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK 1638
Query: 193 ERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLD 252
+ + + Q++ E++ + + ++I+ EN+ K M+ +L +EL ++
Sbjct: 1639 QLRKLQAQMKDCMRELDDTRASREEILAQAK-ENEKKLKSMEAEMIQLQEELAAAERAKR 1697
Query: 253 SQNMKKESLEAEIAHSQVK-----QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREK 307
+++ L EIA+S K +E L ++ +LE ++ + I +++
Sbjct: 1698 QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANL 1757
Query: 308 LLKQIKDDNQEIASMERQLTDTKEKINQFIE-EIRQLDMDLEEHQDPTNYGWK 359
+ QI D ++ER E Q +E + ++L + L+E + +K
Sbjct: 1758 QIDQINTD----LNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYK 1806
Score = 44.3 bits (103), Expect = 2e-04
Identities = 54/271 (19%), Positives = 116/271 (42%), Gaps = 12/271 (4%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQ----LADYNMLVDK 159
K+ + E+ +LQ+ E+ E + + ++R E LA EI G+ L + L +
Sbjct: 1674 KLKSMEAEMIQLQE--ELAAAERAKRQAQQERDE-LADEIANSSGKGALALEEKRRLEAR 1730
Query: 160 L-NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQ-EKQATDD 217
+ E+EE + ++ + + +D I T+ + + E +Q E+Q +
Sbjct: 1731 IAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKEL 1790
Query: 218 IIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLL 277
+K E VK + K + L ++ L++QLD++ ++++ ++ ++ K + VLL
Sbjct: 1791 KVKLQEMEGTVKS-KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLL 1849
Query: 278 H--EKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQ 335
++ E ++DQ + + E+ ++ + N ++R+L D E +
Sbjct: 1850 QVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADA 1909
Query: 336 FIEEIRQLDMDLEEHQDPTNYGWKILEKNTG 366
E+ L L P ++ K G
Sbjct: 1910 MNREVSSLKNKLRRGDLPFVVPRRMARKGAG 1940
Score = 38.9 bits (89), Expect = 0.008
Identities = 35/179 (19%), Positives = 87/179 (48%), Gaps = 4/179 (2%)
Query: 190 IFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQ 249
+FT+ + + R EE + +E++ K ++ EN++ EM+T +L+ E LQ+
Sbjct: 830 LFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLT--EMETLQSQLMAEKLQLQE 887
Query: 250 QLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLL 309
QL ++ + EAE +++ + L E ++LE+ ++ + + + ++ ++ +
Sbjct: 888 QLQAET--ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI 945
Query: 310 KQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSF 368
+++++ +E S ++L K ++++ + + LE+ K+LE F
Sbjct: 946 QELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEF 1004
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 61.2 bits (147), Expect = 1e-09
Identities = 70/337 (20%), Positives = 138/337 (40%), Gaps = 44/337 (13%)
Query: 66 KVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQE 125
K A R Q L + + Q+++ + L + +K+ + ++L+ ++ Y ++
Sbjct: 658 KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEK 717
Query: 126 NSVYLSYEKRAETLAVEIKEL--------------------QGQL-ADYNMLVDKLNTNT 164
YLS E++ E L +IK+L Q QL D + +L+
Sbjct: 718 ---YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774
Query: 165 EMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVE------------EEIEQEK 212
EME+ + L Q E +Q +EKQI + EE+
Sbjct: 775 EMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRI 834
Query: 213 QATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQ 272
Q T ++ + E + E+ T +KL + D+L+ +KE+ + + A +++
Sbjct: 835 QTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKN--SKSEFEKENQKGKAAILDLEK 892
Query: 273 EAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEK 332
E ++L+ + + E K + +E+ ++ Q+K E+ SM+ QL +
Sbjct: 893 TC---KELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLK---LELNSMQEQLIQAQNT 946
Query: 333 INQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFK 369
+ Q +E +QL ++ E + + K +E G K
Sbjct: 947 LKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983
Score = 57.4 bits (137), Expect = 2e-08
Identities = 70/297 (23%), Positives = 131/297 (44%), Gaps = 35/297 (11%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGI-----EMYNQENSVYL------SYEKRA 136
Q+Q+ + L + KIS L K Q+ + Y +E+ + S E++
Sbjct: 997 QQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL 1056
Query: 137 ETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQA 196
++ + Q+ + N L+ +L T E D + Q ++L I E+
Sbjct: 1057 SLAQEDLISNRNQIGNQNKLIQELKTAKATLE--QDSAKKEQQLQERCKALQDIQKEKSL 1114
Query: 197 KEKQI---RSVEEEIE-----QEKQAT--DDIIKNMSFENQVKYLEMKTTNEKLLQELDT 246
KEK++ +S EIE QEK+ T ++ +K+ E+ + +K + L+Q+
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
Query: 247 LQQQLDSQN--MKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEE 304
LQ + DS +++E +I QVK+E L ++ E E+ I E K +G E
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKE-KEVGMKKHE 1233
Query: 305 RE--KLLKQIKDDNQEIA-------SMERQLTDTKEKINQFIEEIRQLDMDLEEHQD 352
KL QI N+ + S +R++++ +++ + EI L+ ++ +QD
Sbjct: 1234 ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQD 1290
Score = 56.6 bits (135), Expect = 3e-08
Identities = 59/297 (19%), Positives = 131/297 (44%), Gaps = 21/297 (7%)
Query: 85 KGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIK 144
KGPQ ++ L L+S ++ELT + L + + Q+ Y E++ +V K
Sbjct: 278 KGPQ-EVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD---YTKLEEKHNEESVSKK 333
Query: 145 ELQGQLADYNMLVDKLNTNTEMEEV-MNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRS 203
+Q L ++ +L + E ++ ++ ++ TQ L +E + K + +++
Sbjct: 334 NIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKA 393
Query: 204 VEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEA 263
++++Q+++ + + E + ++ T +L + L++Q + K E
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
Query: 264 EIAHSQVKQEAV-------------LLHEKLYELESHRDQMIAEDKSIGSPMEER---EK 307
++A Q+K + L H+ + H++Q + + E + E+
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513
Query: 308 LLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKN 364
+L+QI D +Q+I ++E L +KE I+ +E L ++ + T ++ EKN
Sbjct: 514 VLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKN 570
Score = 46.6 bits (109), Expect = 4e-05
Identities = 75/352 (21%), Positives = 151/352 (42%), Gaps = 80/352 (22%)
Query: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYY---LGLLRSKISELTTEVNKLQK 117
LS + K+ H + + ++T Q+ ++K L ++ K+S+++ + +
Sbjct: 819 LSQETKIQHEELNNR----IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKS 874
Query: 118 GIEMYNQEN-SVYLSYEKRAETLAVEIK-ELQGQLADYNMLVD------------KLNTN 163
E NQ+ + L EK + L +++ +++ L + L KL N
Sbjct: 875 EFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELN 934
Query: 164 TEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMS 223
+ E+++ N LK QN++E Q L + I +++ EQ+K+ I+ +
Sbjct: 935 SMQEQLIQAQNTLK-QNEKEEQQL----------QGNINELKQSSEQKKKQ----IEALQ 979
Query: 224 FENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQ-------------- 269
E ++ L+ KL Q+L Q+L ++ K L+ SQ
Sbjct: 980 GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039
Query: 270 -----VKQEAVLLHEKL----YELESHRDQ------MIAEDKSIGSPMEE----REKLL- 309
+Q+ + EKL +L S+R+Q +I E K+ + +E+ +E+ L
Sbjct: 1040 SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099
Query: 310 ---KQIKDDNQEIASMERQLTDTKEKINQFIE-------EIRQLDMDLEEHQ 351
K ++D +E + E++L + K K+ + E EI +L+ +L+ H+
Sbjct: 1100 ERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHK 1151
Score = 40.0 bits (92), Expect = 0.003
Identities = 45/255 (17%), Positives = 110/255 (43%), Gaps = 22/255 (8%)
Query: 107 ELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN--- 163
EL E+ K Q + + + + ++L +++E Q + + + D
Sbjct: 108 ELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ 167
Query: 164 --TEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATD-DIIK 220
TE+ ++ + Y+ ++ + Q + + E + I+ ++ E+ Q D ++K
Sbjct: 168 LATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLK 227
Query: 221 NMSFENQVKY----LEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVL 276
+ Q LE + +EKL E LQ Q S L +E+A QE +
Sbjct: 228 KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKG--PQEVAV 285
Query: 277 LHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQF 336
++L +L+S +++ +++++ + ++E+ ++++ + E + ++ + T
Sbjct: 286 YVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQAT------- 338
Query: 337 IEEIRQLDMDLEEHQ 351
+ Q D+D ++ Q
Sbjct: 339 ---LHQKDLDCQQLQ 350
Score = 38.9 bits (89), Expect = 0.008
Identities = 50/293 (17%), Positives = 129/293 (44%), Gaps = 48/293 (16%)
Query: 107 ELTTEVNKLQ-KGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN-- 163
+L +E+N+L K +E Q + +++ + + ++ + + Q+AD + + +L
Sbjct: 411 QLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK 470
Query: 164 ---TEMEEVMNDYNMLKAQND-------------RETQS-LDVIFTERQAKEKQIRSVEE 206
T E+ + + K Q+ RE Q+ L+ + + K+++I+++E
Sbjct: 471 EKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEA 530
Query: 207 EIEQ--------EKQATDDIIKNMSFENQVKYL-EMKTTNEKLLQELDTLQQQLDSQNMK 257
+++ EK+ D K + E + L +++ N L +++ L ++L +Q+
Sbjct: 531 LLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES 590
Query: 258 KESLEAEIAHSQVKQE----------AVLLHEKLYELESHRDQMIAEDKSIGSPMEEREK 307
+ + + H QV+++ + L + EL S ++ + + ++ + +
Sbjct: 591 HKQAQENL-HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE 649
Query: 308 LL--------KQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQD 352
LL Q D + + + L D ++++N+ ++ Q+ L++ Q+
Sbjct: 650 LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 60.8 bits (146), Expect = 2e-09
Identities = 65/267 (24%), Positives = 131/267 (49%), Gaps = 30/267 (11%)
Query: 100 LLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDK 159
L R K+ ELT +++ ++ Y +E S EK L + + L+ +M++D+
Sbjct: 973 LKRQKVIELTGTARQVKIEMDQYKEELS---KMEKEIMHLKRDGENKAMHLSQLDMILDQ 1029
Query: 160 LNTNTEMEEVMNDYNML-KAQNDRETQSLDVIFTERQAKEKQIRSVEEEIE---QEKQAT 215
T TE+E+ N L K Q+ ET+ + + +R+ E ++++ E++ ++ Q
Sbjct: 1030 --TKTELEKKTNAVKELEKLQHSTETELTEAL-QKREVLETELQNAHGELKSTLRQLQEL 1086
Query: 216 DDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIA----HSQVK 271
D+++ + KY TT + L EL + +++ + K+E LE + A + ++K
Sbjct: 1087 RDVLQKAQLSLEEKY----TTIKDLTAELRECKMEIEDK--KQELLEMDQALKERNWELK 1140
Query: 272 QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKE 331
Q A + + HR +M + + +E+ E ++K+ N++I S+ +L + KE
Sbjct: 1141 QRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSEL---ELKECNKQIESLNDKLQNAKE 1197
Query: 332 KINQ--FI-----EEIRQLDMDLEEHQ 351
++ + FI +EI QL ++E Q
Sbjct: 1198 QLREKEFIMLQNEQEISQLKKEIERTQ 1224
Score = 55.1 bits (131), Expect = 1e-07
Identities = 60/267 (22%), Positives = 125/267 (46%), Gaps = 29/267 (10%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
Q ++L+K+ L S++++ +++ L+K +E E V S ++A + EL+
Sbjct: 675 QEELLEKASNSSKLESEMTKKCSQLLTLEKQLE----EKIVAYS------SIAAKNAELE 724
Query: 148 GQLADYNMLVDKLNTN--TEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVE 205
+L + N + L TN TE E++ + K + + + EKQI +E
Sbjct: 725 QELMEKNEKIRSLETNINTEHEKICLAFEKAKK----------IHLEQHKEMEKQIERLE 774
Query: 206 EEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKK-ESLEAE 264
++E++ Q + K MS Q + E L + L + ++ +NMKK E+L+A
Sbjct: 775 AQLEKKDQQFKEQEKTMSMLQQDIICKQHHL-ESLDRLLTESKGEMKKENMKKDEALKA- 832
Query: 265 IAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMER 324
+QV +E + + + LE +++++ + +EK KQ+K ++E+ +++
Sbjct: 833 -LQNQVSEETIKVRQLDSALEICKEELVLHLNQLEG---NKEKFEKQLKKKSEEVYCLQK 888
Query: 325 QLTDTKEKINQFIEEIRQLDMDLEEHQ 351
+L + + E+ L L++ Q
Sbjct: 889 ELKIKNHSLQETSEQNVILQHTLQQQQ 915
Score = 53.1 bits (126), Expect = 4e-07
Identities = 76/359 (21%), Positives = 146/359 (40%), Gaps = 89/359 (24%)
Query: 75 QGLTGMKTGTKGP-QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLS-- 131
+ L + T +KG +++ + K L L++++SE T +V +L +E+ +E ++L+
Sbjct: 806 ESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQL 865
Query: 132 ------YEKRAETLAVEIKELQGQLADYN----------------------MLVDKLNTN 163
+EK+ + + E+ LQ +L N ML + N
Sbjct: 866 EGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRN 925
Query: 164 TEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATD----DII 219
E+E+ ++ ++E Q +R++ +++R +EE+ E D +I
Sbjct: 926 GELEDTQTKLEKQVSKLEQELQK------QRESSAEKLRKMEEKCESAAHEADLKRQKVI 979
Query: 220 KNMSFENQVKYLEMKTTNEKL--------------------LQELDTLQQQLDSQNMKK- 258
+ QVK +EM E+L L +LD + Q ++ KK
Sbjct: 980 ELTGTARQVK-IEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT 1038
Query: 259 ----------ESLEAEIAHSQVKQEAVL---------LHEKLYELESHRD-----QMIAE 294
S E E+ + K+E + L L +L+ RD Q+ E
Sbjct: 1039 NAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE 1098
Query: 295 DK--SIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ 351
+K +I E + +I+D QE+ M++ L + ++ Q ++ LDM + EH+
Sbjct: 1099 EKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHR 1157
Score = 49.3 bits (116), Expect = 6e-06
Identities = 72/366 (19%), Positives = 156/366 (42%), Gaps = 32/366 (8%)
Query: 18 VGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRP---VTQ 74
VG + R P + +R + + P R G+R G + ++++ A P +
Sbjct: 56 VGASQRLPRRFEFCAAGVRWFSELCPRLPRAGARERV--RGFLTQTRVRSAQSPGGSLPS 113
Query: 75 QGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELT-TEVNKLQKGIEMYN---QENSVYL 130
L M++ + + ++ L + S EL TE + G E+ + ENS Y
Sbjct: 114 DDLGEMESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYA 173
Query: 131 SYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVI 190
R+E L ++++ L +Y+ N + + D + + D +
Sbjct: 174 PNPSRSEKLILDVQPSHPGLLNYS-------------PYENVCKISGSSTDFQKKPRDKM 220
Query: 191 FTERQAKEKQIRSVEEEIEQEKQATDDII-KNMSFENQVKYLEMKTTNEKL-LQELDTLQ 248
F+ +++I+S+ E++ + +Q ++ +N S + + + + T + + L++ Q
Sbjct: 221 FSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQ 280
Query: 249 QQLDSQNMKKE---SLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEER 305
QQ S + +E +LEAE++ + +L E +LE + +I +++S+ EE
Sbjct: 281 QQAASVPILEEQIINLEAEVS-----AQDKVLREAENKLEQSQKMVIEKEQSLQESKEEC 335
Query: 306 EKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNT 365
KL + + ++ ERQ + + + +Q + E + +ILE+N
Sbjct: 336 IKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNL 395
Query: 366 GSFKKQ 371
+ +K+
Sbjct: 396 TNCEKE 401
Score = 48.1 bits (113), Expect = 1e-05
Identities = 51/242 (21%), Positives = 111/242 (45%), Gaps = 26/242 (10%)
Query: 143 IKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTE--------- 193
I EL+ +LA + KL+ N ++ +++ + +E+ L + TE
Sbjct: 559 ISELRIKLAIKEAEIQKLHANLTANQLSQ--SLITCNDSQESSKLSSLETEPVKLGGHQV 616
Query: 194 -RQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLD 252
K++ ++ ++ E+E+Q I+ + + K ++++ N L +++ +
Sbjct: 617 AESVKDQNQHTMNKQYEKERQRLVTGIEEL----RTKLIQIEAENSDL--KVNMAHRTSQ 670
Query: 253 SQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQI 312
Q +++E LE S+++ E +L LE ++ I SI + E E+ ++
Sbjct: 671 FQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQ---EL 727
Query: 313 KDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKI---LEKNTGSFK 369
+ N++I S+E + EKI E+ +++ LE+H++ ++ LEK FK
Sbjct: 728 MEKNEKIRSLETNINTEHEKICLAFEKAKKI--HLEQHKEMEKQIERLEAQLEKKDQQFK 785
Query: 370 KQ 371
+Q
Sbjct: 786 EQ 787
Score = 41.6 bits (96), Expect = 0.001
Identities = 50/265 (18%), Positives = 118/265 (44%), Gaps = 32/265 (12%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L+ + +E+ L++ + +EN+ + +++ +AV+ E+ QL + + KL
Sbjct: 405 LQERCGLYKSELEILKEKLRQLKEENN---NGKEKLRIMAVKNSEVMAQLTESRQSILKL 461
Query: 161 NTNTEMEE--------VMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEK 212
+ E ++ +MN+ LK + + + LD+ E ++ ++RS+E+ I Q
Sbjct: 462 ESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLP 521
Query: 213 QATD--------DIIKNMSFEN-QVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEA 263
+ + SF N + + + N+ ++ E L+ +L + + + L A
Sbjct: 522 LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE---LRIKLAIKEAEIQKLHA 578
Query: 264 EIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASME 323
+ +Q+ Q + ++ + S + E +G ++ + +KD NQ +M
Sbjct: 579 NLTANQLSQSLITCNDS--QESSKLSSLETEPVKLGG-----HQVAESVKDQNQH--TMN 629
Query: 324 RQLTDTKEKINQFIEEIRQLDMDLE 348
+Q ++++ IEE+R + +E
Sbjct: 630 KQYEKERQRLVTGIEELRTKLIQIE 654
Score = 40.0 bits (92), Expect = 0.003
Identities = 48/255 (18%), Positives = 116/255 (45%), Gaps = 18/255 (7%)
Query: 107 ELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEM 166
E+ ++ +L+ +E +Q+ + EK L +I Q L + L+ + +
Sbjct: 765 EMEKQIERLEAQLEKKDQQ---FKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKK 821
Query: 167 EEVMNDYNMLKAQND--RET-------QSLDVIFTERQAKEKQIRSVEEEIEQEKQATDD 217
E + D + QN ET +L++ E Q+ +E+ E++ + +
Sbjct: 822 ENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSE 881
Query: 218 IIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESL---EAEIAHSQVKQEA 274
+ + E ++K ++ T+E+ + TLQQQ Q +++E++ E E ++++++
Sbjct: 882 EVYCLQKELKIKNHSLQETSEQNVILQHTLQQQ--QQMLQQETIRNGELEDTQTKLEKQV 939
Query: 275 VLLHEKLY-ELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKI 333
L ++L + ES +++ ++ S E + +++ + ++ ++ KE++
Sbjct: 940 SKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEEL 999
Query: 334 NQFIEEIRQLDMDLE 348
++ +EI L D E
Sbjct: 1000 SKMEKEIMHLKRDGE 1014
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 59.7 bits (143), Expect = 4e-09
Identities = 59/276 (21%), Positives = 135/276 (48%), Gaps = 23/276 (8%)
Query: 87 PQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKEL 146
P+++ L + + L + +++EL +E K + I ++ S+ + E E+++
Sbjct: 19 PRQEELADNLLISLSKVEVNELKSE--KQENVIHLFRITQSLMKMKAQEVELALEEVEKA 76
Query: 147 QGQLADYNMLVDKLNTNTEMEEVMNDYNMLK-AQNDRETQSL--DVIFTERQA--KEKQI 201
+ A + + T++ ++ N+ M + + R+T+ L ++ E+Q K++++
Sbjct: 77 GEEQAKFENQL-----KTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDREL 131
Query: 202 RSVEEEIEQEKQATDDI-IKNMSFENQVKYLE-----MKTTNEKLLQELDTLQQQLDSQN 255
+E+E+E+EK+ + + ++N EN+ L +K NE+L Q++ Q+Q+DSQ
Sbjct: 132 EDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQ- 190
Query: 256 MKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDD 315
K+ L S + + L +K YEL + D++ ++ + +++ K +++
Sbjct: 191 -KETLLSRRGEDSDYRSQ---LSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEES 246
Query: 316 NQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ 351
QE+ M + K ++Q I QL + + +Q
Sbjct: 247 VQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQ 282
Score = 53.9 bits (128), Expect = 2e-07
Identities = 65/315 (20%), Positives = 139/315 (44%), Gaps = 36/315 (11%)
Query: 71 PVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRS-KISELTTEVNKLQKGIE-----MYNQ 124
P ++ + MK + QR+ G+L S K++ + E KL+ +E + +Q
Sbjct: 2128 PELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQ 2187
Query: 125 ENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQND--- 181
+ Y S K E + E + L+ +L +KL E++N+ ++ +
Sbjct: 2188 LSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKR 2247
Query: 182 -------------RETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQV 228
+++S I R + K ++ +E +I ++ Q+ D+ K + E
Sbjct: 2248 LQFAESRGPQLEGADSKSWKSIVVTRMYETK-LKELETDIAKKNQSITDL-KQLVKEATE 2305
Query: 229 KYLEMKTTNEKLLQELDTLQQQLDS----QNMKKESLEAEIAHSQVKQEAVLLHEKLYEL 284
+ ++ NE L Q++ L+ + Q +K+E +A+ Q+ +E E ++++
Sbjct: 2306 REQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKA---ELIHQI 2362
Query: 285 ESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLD 344
E+++DQ AE S + + ++L ++IKD ++ + + KE+I + +E+ D
Sbjct: 2363 EANKDQSGAE-----STIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFD 2417
Query: 345 MDLEEHQDPTNYGWK 359
E + Y +K
Sbjct: 2418 PSFFEEIEDLKYNYK 2432
Score = 50.1 bits (118), Expect = 3e-06
Identities = 60/301 (19%), Positives = 136/301 (45%), Gaps = 32/301 (10%)
Query: 93 DKSYYLGLLRSKISELTTEVNKLQKGIEMYNQE----NSVYLSYEKRAETLAVEIKELQG 148
D+ L L ++++ EL EV+KL++ ++ ++ N+ S +K E+L +++ + Q
Sbjct: 1134 DRQRILELEKNEM-ELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQA 1192
Query: 149 QLADYNML-----------------VDKLNTNTEMEEVMNDYNM-LKAQNDRETQSLDVI 190
Q + +++ + KL + T + M YN+ L+ + D + Q+L
Sbjct: 1193 QSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYA 1252
Query: 191 FTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQ 250
E + + K +R + + ++ + + F + ++++ K++QE+ QQ+
Sbjct: 1253 RLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTM--IQLQNDKLKIMQEMKNSQQE 1310
Query: 251 LDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLK 310
+NM+ ++LE E+ +++ L + + M E+ + + KL +
Sbjct: 1311 --HRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRL-----QELKLNR 1363
Query: 311 QIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKK 370
++ D +EI + +++ + I+ EEI Q + EE Q + LE+ F +
Sbjct: 1364 ELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDR 1423
Query: 371 Q 371
Q
Sbjct: 1424 Q 1424
Score = 40.8 bits (94), Expect = 0.002
Identities = 48/267 (17%), Positives = 116/267 (43%), Gaps = 30/267 (11%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQ-------ENSVYLSY-EKRAETLAVEIKELQGQLAD 152
L+ K +L ++ QK I+ + E+S Y S K+ L + E+Q L +
Sbjct: 169 LKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQ-TLTE 227
Query: 153 YNMLVDKLNTNT---------EMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRS 203
N ++ N EME++ ++YN +KA + +D + E + Q++
Sbjct: 228 ANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQE 287
Query: 204 VEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDS--QNMKKESL 261
+ + ++ + + D I+ ++ + + L + + ++++++ QQ L + + +K L
Sbjct: 288 LTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIE----YQQMLHNLREKLKNAQL 343
Query: 262 EAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIAS 321
+A+ K + L + + E +S + + + ME+ +++ +K++ Q
Sbjct: 344 DAD------KSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKG 397
Query: 322 MERQLTDTKEKINQFIEEIRQLDMDLE 348
T KI ++ +++ + E
Sbjct: 398 ASTLSQQTHMKIQSTLDILKEKTKEAE 424
Score = 36.6 bits (83), Expect = 0.037
Identities = 47/220 (21%), Positives = 98/220 (44%), Gaps = 18/220 (8%)
Query: 142 EIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQI 201
E+ E +L DY V L + E+ N N +K + DRE ++++ E E +I
Sbjct: 440 ELVEALKRLKDYESGVYGLED--AVVEIKNCKNQIKIR-DRE---IEILTKEINKLELKI 493
Query: 202 RSVEEEIEQEKQATDDIIKNM----SFENQ--VKYLEMKTTNEKLLQELDTLQQQLDSQN 255
+E E ++ K M F N +K + + N+ LL+E+++L+++
Sbjct: 494 SDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLK 553
Query: 256 MKKESLEAE----IAHSQVKQEAVLLHEKLYELE--SHRDQMIAEDKSIGSPMEEREKLL 309
K + E A S + E + L E + + + S R + K++ + E L
Sbjct: 554 KKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLS 613
Query: 310 KQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEE 349
+++ + +++ + + K+ + +EE +QL+ ++E
Sbjct: 614 RELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKE 653
Score = 35.8 bits (81), Expect = 0.064
Identities = 44/195 (22%), Positives = 89/195 (45%), Gaps = 12/195 (6%)
Query: 81 KTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLA 140
+T K + I K+ + L+ + E T K+ K E Q+ + + AET
Sbjct: 2276 ETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQ 2335
Query: 141 VEIKELQG-QLADYNM------LVDKLNTNTEM---EEVMNDYNMLKAQ-NDRETQSLDV 189
+ELQ +LA++ + L+ ++ N + E + D + LK + D ETQ L +
Sbjct: 2336 GLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQ-LKM 2394
Query: 190 IFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQ 249
E+Q +++I+ +++E+E + + I+++ + + + + EK+ + + L
Sbjct: 2395 SDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGV 2454
Query: 250 QLDSQNMKKESLEAE 264
+L S E E E
Sbjct: 2455 ELTSPVAASEEFEDE 2469
Score = 35.0 bits (79), Expect = 0.11
Identities = 63/298 (21%), Positives = 129/298 (43%), Gaps = 54/298 (18%)
Query: 119 IEMYNQENSVYLSYEKRAETLAVEIKELQGQLADY----NMLVDKLN----TNTEMEEVM 170
+E+ N +N + + ++ E L EI +L+ +++D+ L +++ T ++ E
Sbjct: 463 VEIKNCKNQIKIR-DREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFR 521
Query: 171 NDYNMLKAQNDRETQSL----DVIFTERQAKEKQIRSVEEEIEQEKQATD-------DII 219
N ++ + Q E Q L + + ER +K+IR + +E ++ AT ++
Sbjct: 522 NSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQE-RGKRSATSGLTTEDLNLT 580
Query: 220 KNMS-----FENQVKYLEMK------TTNEKLLQELDTLQQQLDS--------QNMKKES 260
+N+S E ++ L +K + NE L +EL ++ L+ QN KE
Sbjct: 581 ENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKEL 640
Query: 261 LEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQE-- 318
+E + Q+++ + + + E++ D E I + E+L+ I+ N E
Sbjct: 641 VEE---NKQLEEGMKEILQAIKEMQKDPDVKGGETSLI---IPSLERLVNAIESKNAEGI 694
Query: 319 ------IASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKK 370
+ + QLT E++ Q + E R+ ++ + N LEK T ++
Sbjct: 695 FDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQ 752
Score = 34.7 bits (78), Expect = 0.14
Identities = 46/228 (20%), Positives = 108/228 (47%), Gaps = 15/228 (6%)
Query: 126 NSVYLSYEKRAETLAVEIKEL-QGQLADY-NMLVDKLNTNTEMEEVMNDYNMLKAQNDRE 183
NS +S K+ L E+KEL + Q A++ + + L T+ + E N + + +
Sbjct: 1049 NSDIVSISKKITML--EMKELNERQRAEHCQKMYEHLRTSLKQMEERN-FELETKFAELT 1105
Query: 184 TQSLDVIFTERQAKEKQIRSVEEEI-EQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQ 242
+LD E+ +++ SV + + + ++Q ++ KN E +V+ +++ ++ +
Sbjct: 1106 KINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKN-EMELKVEVSKLREISDIARR 1164
Query: 243 ELDTLQQQLDSQNMKKESLEAEI----AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSI 298
+++ L Q S++ + ESL ++ A S K LH+ L+ + + +SI
Sbjct: 1165 QVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESI 1224
Query: 299 GSPMEERE----KLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQ 342
S +++ E +L +++ + Q + + + + + Q I+ +R+
Sbjct: 1225 TSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRR 1272
Score = 33.5 bits (75), Expect = 0.32
Identities = 35/155 (22%), Positives = 75/155 (48%), Gaps = 14/155 (9%)
Query: 207 EIEQEKQA--------TDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKK 258
E++ EKQ T ++K + E ++ E+ EK +E + QL ++ MK
Sbjct: 39 ELKSEKQENVIHLFRITQSLMKMKAQEVELALEEV----EKAGEEQAKFENQLKTKVMKL 94
Query: 259 ESLEAEIA-HSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQ 317
E+ E E+A S ++ L ++ +LE +Q E + + +E+ +K+ +Q+ N+
Sbjct: 95 EN-ELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNE 153
Query: 318 EIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQD 352
E + +L +++ + E++ Q +D ++ D
Sbjct: 154 EAENENSKLRRENKRLKKKNEQLCQDIIDYQKQID 188
Score = 33.5 bits (75), Expect = 0.32
Identities = 40/196 (20%), Positives = 84/196 (42%), Gaps = 19/196 (9%)
Query: 166 MEEVMNDYNMLKAQNDRETQSL--DVIFTERQAKEKQIRSVEEEIEQ-EKQATDDIIKNM 222
+E+ + DYN K R QSL +E++ + + ++++EE + E Q D IK
Sbjct: 801 LEDSLEDYNR-KFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVK 859
Query: 223 SFENQVKYLEMKT--------TNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEA 274
+ N + L+M + N + + L ++ L Q LE ++ KQ+
Sbjct: 860 EYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKN 919
Query: 275 VLLH------EKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTD 328
LL EK+ L+ ++ I + ++ + + L +++ N++ + + D
Sbjct: 920 ELLSMEAEVCEKIGCLQRFKEMAIFKIAAL-QKVVDNSVSLSELELANKQYNELTAKYRD 978
Query: 329 TKEKINQFIEEIRQLD 344
+K N ++ L+
Sbjct: 979 ILQKDNMLVQRTSNLE 994
Score = 31.6 bits (70), Expect = 1.2
Identities = 65/335 (19%), Positives = 131/335 (39%), Gaps = 62/335 (18%)
Query: 84 TKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEI 143
TKG Q+ I ++++ + ++ EL +L K E N++ YE+ +L EI
Sbjct: 1338 TKGAQKVI---NWHMKIEELRLQELKLN-RELVKDKEEIKYLNNIISEYERTISSLEEEI 1393
Query: 144 KE------------------LQGQLADYNMLVDK-LNTNTEMEEVMNDY--------NML 176
+ L+ QL ++ ++ LN + EE N L
Sbjct: 1394 VQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQL 1453
Query: 177 KAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKY-LEMKT 235
+ + +++ +I R + ++E+ + A +I+ N+++ L
Sbjct: 1454 EIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATA 1513
Query: 236 TNEKLLQELDTLQQQLDSQ-----------------NMKKESLEA-----EIAHSQVKQE 273
EKL+ EL + + S N K+E L+ E A + ++E
Sbjct: 1514 EREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREE-QRE 1572
Query: 274 AVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQ------EIASMERQLT 327
V HE+ + HR ++ A D S+ + L+KQ +A ME+ +
Sbjct: 1573 IVKKHEEDLHILHHRLELQA-DSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVA 1631
Query: 328 DTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILE 362
+ + ++ + +++++ DLE ++ T K E
Sbjct: 1632 EQDDSLSSLLVKLKKVSQDLERQREITELKVKEFE 1666
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 59.7 bits (143), Expect = 4e-09
Identities = 62/298 (20%), Positives = 128/298 (42%), Gaps = 40/298 (13%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L + LT V +L+ ++ S L EK + L+ +++ L+ ++
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ-------- 516
Query: 161 NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI-- 218
E + + N N+ K + Q I T R+ E+QI+ +E+E E Q +
Sbjct: 517 ----EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ 572
Query: 219 ---------IKNMSFENQVKYLEMKTTNEKLLQ-ELDTLQQQLDSQNMKK-----ESLEA 263
+K++ EN++ + +K T+ KL + E + Q + + ++ K+ E LE
Sbjct: 573 RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
Query: 264 EIAHSQVKQEAV--------LLHEKLYELESHRDQMIAEDKSIGSPMEEREKL---LKQI 312
E+ H + + E + + EK+ LE ++ E++ + ++ + L L+ +
Sbjct: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESL 692
Query: 313 KDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKK 370
+ +N ++ +L E + ++ QL ++ +E + K LE SFKK
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKK 750
Score = 57.4 bits (137), Expect = 2e-08
Identities = 60/284 (21%), Positives = 134/284 (47%), Gaps = 25/284 (8%)
Query: 103 SKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNT 162
SK+S++ E +++K +E Y ++ +RAE L E+ L+ + N L+ K T
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKG-------ERAEELENELHHLEKE----NELLQKKIT 649
Query: 163 NTEME-EVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKN 221
N ++ E + ++ +RE + L + Q+ S+E+E Q + ++ +N
Sbjct: 650 NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRN 709
Query: 222 MSFEN--QVKYLEMKTTNEKLLQELDTLQQQLD---SQNMKKESLEA-----EIAHSQVK 271
+ +K +++ N++L E + L++ L+ + K E LE +I + +++
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ 769
Query: 272 QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEE---REKLLKQIKDDNQEIASMERQLTD 328
+ ++K+ +LES + E++++ +EE K L+Q++ +N+ + QL
Sbjct: 770 KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK 829
Query: 329 TKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKKQV 372
K+++ + + +RQ + + N LEK + K++
Sbjct: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873
Score = 45.1 bits (105), Expect = 1e-04
Identities = 53/315 (16%), Positives = 127/315 (40%), Gaps = 19/315 (6%)
Query: 77 LTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQ----------KGIEMYNQEN 126
L K + ++++ +K+ L + ++ ++ E+ +LQ + MY E
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL 312
Query: 127 SVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQS 186
R + L E+ + +L D ++ E +V+ + + T++
Sbjct: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 187 LDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQ---E 243
E + + Q+++ ++E E+ I+ + EN + K + ++ L E
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE 432
Query: 244 LDTLQQQLDSQNMKKESLEAEIAHS------QVKQEAVLLHEKLYELESHRDQMIAEDKS 297
L+ + + + ++SL E+ +++ E L + + EL + D +
Sbjct: 433 LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASK 492
Query: 298 IGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYG 357
I +E ++L K+++ EI ++ L + + ++E QL+ +E ++ +
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 358 WKILEKNTGSFKKQV 372
KILE+ + V
Sbjct: 553 IKILEQENEHLNQTV 567
Score = 44.7 bits (104), Expect = 1e-04
Identities = 56/266 (21%), Positives = 118/266 (44%), Gaps = 16/266 (6%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L + ++L + +L+ +M E L K ET+A E K+L G+ N +L
Sbjct: 1198 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1257
Query: 161 NTNTEMEEVMNDYNMLKA---QNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDD 217
TE+ + D+ LK+ + E L+ F++ + + +Q+ ++ + +
Sbjct: 1258 LKETEV--LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ 1315
Query: 218 IIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNM-KKESLEAEIAHSQVKQEAVL 276
+ N+ EN+ +++T +LQ L+Q ++S+++ E + ++++++
Sbjct: 1316 LKGNLEEENRHLLDQIQTL---MLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEK 1372
Query: 277 LHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQF 336
L EK+ + D + ++ R KL+K KD N+E LT T+ ++
Sbjct: 1373 LEEKIMDQYKFYDPSPPRRRGNWITLKMR-KLIKSKKDINRE-RQKSLTLTPTRSDSSEG 1430
Query: 337 IEEIRQLDMDLEEHQDPTNYGWKILE 362
L + ++ QD ++ G LE
Sbjct: 1431 F-----LQLPHQDSQDSSSVGSNSLE 1451
Score = 42.0 bits (97), Expect = 9e-04
Identities = 60/314 (19%), Positives = 125/314 (39%), Gaps = 55/314 (17%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
Q+ + + + + L S++ +L E LQK +E + EK ++L E +L+
Sbjct: 769 QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN---DRETQSLDV-IFTERQAKEKQIRS 203
+L E+++ + N +K N + +T S ++ I+ E + K++
Sbjct: 829 KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK 888
Query: 204 VEEEIEQEKQATDDI-----IKNMSFENQVKYLEMKTTNEKLLQELD------------- 245
+E+ K+AT DI ++ ++K +M EKL EL+
Sbjct: 889 ENKELV--KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE 946
Query: 246 -----------------TLQQQLDSQNMKKESLEAEIAHS-----QVKQEAVLLHEKLYE 283
TL++ L+ + K +LEA + S Q++QE + +
Sbjct: 947 QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1006
Query: 284 LESHRDQ---------MIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN 334
L+ +D+ + ED +E + L ++KD E+ L K+ +
Sbjct: 1007 LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK 1066
Query: 335 QFIEEIRQLDMDLE 348
++++ + +L+
Sbjct: 1067 TQLKQLETQNNNLQ 1080
Score = 35.8 bits (81), Expect = 0.064
Identities = 37/151 (24%), Positives = 71/151 (47%), Gaps = 26/151 (17%)
Query: 228 VKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVL---LHEKLY-- 282
V+ + K +L QEL+ +QL + E +E E+ Q + +L ++Y
Sbjct: 251 VELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
Query: 283 ELESHRDQMIAEDKSIGSPMEEREKL---------LKQIKDDNQEI----ASMERQLTDT 329
EL++ R++ + DK +E+L ++++K+DNQ + +E QL T
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 330 K---EKINQFIEEIRQL-----DMDLEEHQD 352
+ +K+++ +E QL DM++E D
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMD 401
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 59.7 bits (143), Expect = 4e-09
Identities = 62/298 (20%), Positives = 128/298 (42%), Gaps = 40/298 (13%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L + LT V +L+ ++ S L EK + L+ +++ L+ ++
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ-------- 516
Query: 161 NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI-- 218
E + + N N+ K + Q I T R+ E+QI+ +E+E E Q +
Sbjct: 517 ----EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ 572
Query: 219 ---------IKNMSFENQVKYLEMKTTNEKLLQ-ELDTLQQQLDSQNMKK-----ESLEA 263
+K++ EN++ + +K T+ KL + E + Q + + ++ K+ E LE
Sbjct: 573 RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
Query: 264 EIAHSQVKQEAV--------LLHEKLYELESHRDQMIAEDKSIGSPMEEREKL---LKQI 312
E+ H + + E + + EK+ LE ++ E++ + ++ + L L+ +
Sbjct: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESL 692
Query: 313 KDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKK 370
+ +N ++ +L E + ++ QL ++ +E + K LE SFKK
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKK 750
Score = 57.4 bits (137), Expect = 2e-08
Identities = 60/284 (21%), Positives = 134/284 (47%), Gaps = 25/284 (8%)
Query: 103 SKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNT 162
SK+S++ E +++K +E Y ++ +RAE L E+ L+ + N L+ K T
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKG-------ERAEELENELHHLEKE----NELLQKKIT 649
Query: 163 NTEME-EVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKN 221
N ++ E + ++ +RE + L + Q+ S+E+E Q + ++ +N
Sbjct: 650 NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRN 709
Query: 222 MSFEN--QVKYLEMKTTNEKLLQELDTLQQQLD---SQNMKKESLEA-----EIAHSQVK 271
+ +K +++ N++L E + L++ L+ + K E LE +I + +++
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ 769
Query: 272 QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEE---REKLLKQIKDDNQEIASMERQLTD 328
+ ++K+ +LES + E++++ +EE K L+Q++ +N+ + QL
Sbjct: 770 KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK 829
Query: 329 TKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKKQV 372
K+++ + + +RQ + + N LEK + K++
Sbjct: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873
Score = 52.4 bits (124), Expect = 7e-07
Identities = 60/307 (19%), Positives = 131/307 (42%), Gaps = 37/307 (12%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYN------ 154
L + SEL E KL+K ++ + S EK L E EL+ +
Sbjct: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
Query: 155 --MLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEK 212
+ ++ +E E++ +LKA + ++T+ L+V + + ++++ E ++
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKA-SFKKTERLEVSYQGLDIENQRLQKTLENSNKKI 779
Query: 213 QATDDIIKNMSFENQV--KYLEMKTTNEKLLQELDTLQQQLDSQN--MKKESLEAEIAHS 268
Q + ++++ ENQ K LE + K L++L+ + L+ + ++K+ + E +
Sbjct: 780 QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENK 839
Query: 269 QVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPM--------------EEREKLLKQIKD 314
+++Q+A + L E + E+K++ + +E ++L+K+
Sbjct: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATI 899
Query: 315 DNQEIASMERQLTDTK----------EKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKN 364
D + + ++ L K EK+ +E+I L + T+ +K+LE
Sbjct: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESK 959
Query: 365 TGSFKKQ 371
S K+
Sbjct: 960 LESTLKK 966
Score = 45.1 bits (105), Expect = 1e-04
Identities = 53/315 (16%), Positives = 127/315 (40%), Gaps = 19/315 (6%)
Query: 77 LTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQ----------KGIEMYNQEN 126
L K + ++++ +K+ L + ++ ++ E+ +LQ + MY E
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL 312
Query: 127 SVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQS 186
R + L E+ + +L D ++ E +V+ + + T++
Sbjct: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 187 LDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQ---E 243
E + + Q+++ ++E E+ I+ + EN + K + ++ L E
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE 432
Query: 244 LDTLQQQLDSQNMKKESLEAEIAHS------QVKQEAVLLHEKLYELESHRDQMIAEDKS 297
L+ + + + ++SL E+ +++ E L + + EL + D +
Sbjct: 433 LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASK 492
Query: 298 IGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYG 357
I +E ++L K+++ EI ++ L + + ++E QL+ +E ++ +
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 358 WKILEKNTGSFKKQV 372
KILE+ + V
Sbjct: 553 IKILEQENEHLNQTV 567
Score = 44.7 bits (104), Expect = 1e-04
Identities = 56/266 (21%), Positives = 118/266 (44%), Gaps = 16/266 (6%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L + ++L + +L+ +M E L K ET+A E K+L G+ N +L
Sbjct: 1197 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1256
Query: 161 NTNTEMEEVMNDYNMLKA---QNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDD 217
TE+ + D+ LK+ + E L+ F++ + + +Q+ ++ + +
Sbjct: 1257 LKETEV--LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ 1314
Query: 218 IIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNM-KKESLEAEIAHSQVKQEAVL 276
+ N+ EN+ +++T +LQ L+Q ++S+++ E + ++++++
Sbjct: 1315 LKGNLEEENRHLLDQIQTL---MLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEK 1371
Query: 277 LHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQF 336
L EK+ + D + ++ R KL+K KD N+E LT T+ ++
Sbjct: 1372 LEEKIMDQYKFYDPSPPRRRGNWITLKMR-KLIKSKKDINRE-RQKSLTLTPTRSDSSEG 1429
Query: 337 IEEIRQLDMDLEEHQDPTNYGWKILE 362
L + ++ QD ++ G LE
Sbjct: 1430 F-----LQLPHQDSQDSSSVGSNSLE 1450
Score = 42.4 bits (98), Expect = 7e-04
Identities = 60/313 (19%), Positives = 125/313 (39%), Gaps = 54/313 (17%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
Q+ + + + + L S++ +L E LQK +E + EK ++L E +L+
Sbjct: 769 QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQN---DRETQSLDV-IFTERQAKEKQIRS 203
+L E+++ + N +K N + +T S ++ I+ E + K++
Sbjct: 829 KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK 888
Query: 204 VEEEIEQEKQATDDI-----IKNMSFENQVKYLEMKTTNEKLLQELD------------- 245
+E+ K+AT DI ++ ++K +M EKL EL+
Sbjct: 889 ENKELV--KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE 946
Query: 246 ----------------TLQQQLDSQNMKKESLEAEIAHS-----QVKQEAVLLHEKLYEL 284
TL++ L+ + K +LEA + S Q++QE + + L
Sbjct: 947 QSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL 1006
Query: 285 ESHRDQ---------MIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQ 335
+ +D+ + ED +E + L ++KD E+ L K+ +
Sbjct: 1007 KQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKT 1066
Query: 336 FIEEIRQLDMDLE 348
++++ + +L+
Sbjct: 1067 QLKQLETQNNNLQ 1079
Score = 35.8 bits (81), Expect = 0.064
Identities = 37/151 (24%), Positives = 71/151 (47%), Gaps = 26/151 (17%)
Query: 228 VKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVL---LHEKLY-- 282
V+ + K +L QEL+ +QL + E +E E+ Q + +L ++Y
Sbjct: 251 VELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
Query: 283 ELESHRDQMIAEDKSIGSPMEEREKL---------LKQIKDDNQEI----ASMERQLTDT 329
EL++ R++ + DK +E+L ++++K+DNQ + +E QL T
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 330 K---EKINQFIEEIRQL-----DMDLEEHQD 352
+ +K+++ +E QL DM++E D
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMD 401
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 59.7 bits (143), Expect = 4e-09
Identities = 60/283 (21%), Positives = 122/283 (43%), Gaps = 31/283 (10%)
Query: 72 VTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLS 131
V G + +K + + +DK L+ K LT E+ + K ++ +
Sbjct: 651 VISGGASDLKAKARRWDEKAVDK------LKEKKERLTEELKEQMKA----KRKEAELRQ 700
Query: 132 YEKRAETLAVEIKELQGQLADYNM------LVDKLNTNTEMEEV---MNDYNMLKAQNDR 182
+ +A L + +K Q L L +K +E+ +ND + +R
Sbjct: 701 VQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSRER 760
Query: 183 ETQSL--------DVIFTE--RQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLE 232
E + L D +F E R+ + IR EEE + K+ + K + FENQ L
Sbjct: 761 EMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEE--KVKRQNEIAKKRLEFENQKTRLG 818
Query: 233 MKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMI 292
++ EK + D + + Q +KK+ E E + ++ ++ E + +L+ ++Q +
Sbjct: 819 IQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHL 878
Query: 293 AEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQ 335
A+ + E E++ K++ N+E+ +++++T + K+ Q
Sbjct: 879 AKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQ 921
Score = 51.2 bits (121), Expect = 1e-06
Identities = 57/267 (21%), Positives = 114/267 (42%), Gaps = 33/267 (12%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L SK E+ + ++ K + ++ + + + EIKE +L K
Sbjct: 242 LASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKA 301
Query: 161 NTNT-----EMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQAT 215
NT ++E + + +D + E + EK + EE +E+E Q+
Sbjct: 302 KENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQ 361
Query: 216 DDIIKNMSFE-NQVK-YLEMKTTNEK----LLQELDTL-------QQQLDSQNMKKESLE 262
++++ E NQVK Y +K K L QEL+ Q +LD + KK E
Sbjct: 362 G---RDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETE 418
Query: 263 AEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASM 322
A+I +KL E+E ++ ++ ++ I + + E+ K + +E+
Sbjct: 419 AKIK------------QKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMA 466
Query: 323 ERQLTDTKEKINQFIEEIRQLDMDLEE 349
+R++ + +++NQ +E++ +D +E
Sbjct: 467 KRRIDEINKELNQVMEQLGDARIDRQE 493
Score = 40.4 bits (93), Expect = 0.003
Identities = 33/110 (30%), Positives = 59/110 (53%), Gaps = 12/110 (10%)
Query: 238 EKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKS 297
+KL ++ + L ++L Q MK + EAE+ QV+ +A L +L +S +Q + +
Sbjct: 672 DKLKEKKERLTEELKEQ-MKAKRKEAELR--QVQSQAHGLQMRLKYSQSDLEQ--TKTRH 726
Query: 298 IGSPMEEREKLLKQ-------IKDDNQEIASMERQLTDTKEKINQFIEEI 340
+ ++E+ KL + I D + I S ER++ D KEK+NQ +E+
Sbjct: 727 LALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEV 776
Score = 40.0 bits (92), Expect = 0.003
Identities = 41/233 (17%), Positives = 92/233 (39%), Gaps = 39/233 (16%)
Query: 132 YEKRAETLAVEIKE-----LQGQLADYNMLVDKLNTNTEME-----EVMNDYNMLKAQND 181
Y + E L + IK QG + M K T E E+ +Y+ K +
Sbjct: 117 YSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMV 176
Query: 182 RETQSLDVIFTERQ---AKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNE 238
+ + + ++ A+ K+ + +EE ++ ++ D++++ K + E
Sbjct: 177 KAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIE 236
Query: 239 KLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSI 298
KL +EL + ++++ + + +E D++ + K +
Sbjct: 237 KLNKELASKNKEIEKDKKRMDKVE--------------------------DELKEKKKEL 270
Query: 299 GSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ 351
G M E++++ K+IK+ + E+ Q KE + I+++ L+ Q
Sbjct: 271 GKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQ 323
Score = 37.0 bits (84), Expect = 0.029
Identities = 51/271 (18%), Positives = 121/271 (44%), Gaps = 42/271 (15%)
Query: 108 LTTEVNKLQKGIEMYNQENSVYLS------YEKRAETLAVEIKELQGQLADYNMLVDKLN 161
L E K + GI++ ++N + +E+ + EI++L+ + + ++D+
Sbjct: 808 LEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDE-- 865
Query: 162 TNTEMEEVMNDYNMLKAQNDRETQSLDVIFT-------ERQAKEKQIRSVEEEIEQEKQA 214
T +++++ N + K++ + + ++ I E +K++ ++E ++EQ++
Sbjct: 866 TMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSD 925
Query: 215 TDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQ--------QQLDSQNMKKESLEAEI- 265
++++ ++ +K K T + + QE + Q Q++ S ++ +E +
Sbjct: 926 RHNLLQACKMQD-IKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYG 984
Query: 266 ----------AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDD 315
A ++KQE L +KL E +S ++ A + M+ EK L+ ++D
Sbjct: 985 DLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPN------MKAMEK-LESVRDK 1037
Query: 316 NQEIASMERQLTDTKEKINQFIEEIRQLDMD 346
QE + +K Q E+I++ D
Sbjct: 1038 FQETSDEFEAARKRAKKAKQAFEQIKKERFD 1068
Score = 28.9 bits (63), Expect = 7.8
Identities = 42/206 (20%), Positives = 80/206 (38%), Gaps = 40/206 (19%)
Query: 73 TQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSY 132
T L +K + ++ DK++ + +R K+ E+ LQK
Sbjct: 866 TMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQK--------------- 910
Query: 133 EKRAETLAVEIKELQGQLADYNMLVDKLNTNTEM---EEVMNDYNMLKAQNDRETQSLDV 189
E A+E K Q + +N+L + ++ + M+D + Q + +Q D
Sbjct: 911 ----EVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDIS----QEEGSSQGEDS 962
Query: 190 IFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQ 249
+ ++ R EI+ D +K+ E ++K QE++TLQQ
Sbjct: 963 VSGSQRISSIYAREALIEIDYGDLCED--LKDAQAEEEIK------------QEMNTLQQ 1008
Query: 250 QLDSQNMKKESLEAEIAHSQVKQEAV 275
+L+ Q + + A + K E+V
Sbjct: 1009 KLNEQQSVLQRIAAPNMKAMEKLESV 1034
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 58.9 bits (141), Expect = 7e-09
Identities = 84/371 (22%), Positives = 164/371 (44%), Gaps = 48/371 (12%)
Query: 10 ARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARP----GSRGCPIGTGGVLSSQI 65
+RP++ G V + G PP+G + G PP + P G C + L +++
Sbjct: 1273 SRPLTPGTV-VYGPPPAGAPMVYG------PPPPNFSIPFIPMGVLHCNVPEHHNLENEV 1325
Query: 66 K-----VAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
+ H ++ M+ + ++++ + + + L + L EV +L + ++
Sbjct: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
Query: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLN----TNTEMEEVMNDYNML 176
Q+ + E+L E+ E++ L + +VD++ T + + + + L
Sbjct: 1386 KRQQQKDFI---DGNVESLMTEL-EIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRL 1441
Query: 177 KAQNDRE-------TQSLDVIFTERQAKEKQIRSVEEEIEQEKQATD-DIIKN----MSF 224
A+ + E T++ FT+ + Q S EE+E+ Q T +++K S
Sbjct: 1442 LAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSL 1501
Query: 225 ENQVKYLEM-KTTNEKLLQELDTLQQQLDSQ----NMKKESLEAEIAHSQVKQEAVLLHE 279
+ K LE K E++L+E++ + DS + KKE L E+ Q Q+ + + E
Sbjct: 1502 QADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEEL---QKLQKDIEMAE 1558
Query: 280 KLYELESHRDQMIAEDKSI-GSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIE 338
+ E H Q++ E + + + E EKL Q+ QE+A ++RQL KE+++
Sbjct: 1559 RN---EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG 1615
Query: 339 EIRQLDMDLEE 349
+ Q DL+E
Sbjct: 1616 SMVQAKADLQE 1626
Score = 54.7 bits (130), Expect = 1e-07
Identities = 56/257 (21%), Positives = 120/257 (46%), Gaps = 24/257 (9%)
Query: 104 KISELTTEV--NKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLN 161
KISE ++ +L +++ N+ L E + E EI Q ++ D + +D L+
Sbjct: 485 KISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLD 544
Query: 162 TNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKN 221
+ ++ +KAQ + Q LD++ + Q E ++ + I +E + D+ +
Sbjct: 545 SKDPK------HSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQ 598
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQ--NMKKESLEAEIAHSQVKQEAVLLHE 279
++ E Q+ NE L ++L+ + L +K ++ +A+ +++ E L +
Sbjct: 599 LT-EGQI------AANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQ 651
Query: 280 KLYELESHRDQM--IAED-KSIGSPMEEREKLLKQIKDDNQEIASMERQLT----DTKEK 332
+L E+E RDQ+ +A D +++ + E E L++ + N + + L+ + + +
Sbjct: 652 RLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEAR 711
Query: 333 INQFIEEIRQLDMDLEE 349
+N E QL +LE+
Sbjct: 712 LNLRDAEANQLKEELEK 728
Score = 53.1 bits (126), Expect = 4e-07
Identities = 58/266 (21%), Positives = 122/266 (45%), Gaps = 34/266 (12%)
Query: 102 RSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLN 161
+S + +L V KLQ+ ++ N++ +L +I +Q QL + V+ L
Sbjct: 1821 QSNLEKLELNVRKLQQELDQLNRDKL----------SLHNDISAMQQQLQEKREAVNSLQ 1870
Query: 162 TNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIE--QEKQATDDII 219
E+ V + N+ K T+ DV+ +E+ +K I E Q+++ T
Sbjct: 1871 E--ELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETK--- 1925
Query: 220 KNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHE 279
+ Q++ L+ NE +L +QQ++ Q ++KE E S+++ V L E
Sbjct: 1926 -----QQQLQVLQ----NEIEENKLKLVQQEMMFQRLQKER---ESEESKLETSKVTLKE 1973
Query: 280 KLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTK----EKINQ 335
+ ++LE ++ + S + E+ ++ ++++ + S+E+ L+ TK E+ Q
Sbjct: 1974 QQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQ 2033
Query: 336 FIEEIRQLDMDLEEHQDPTNYGWKIL 361
+E+ +L + L++ D + +L
Sbjct: 2034 LVEKSGEL-LALQKEADSMRADFSLL 2058
Score = 49.3 bits (116), Expect = 6e-06
Identities = 61/301 (20%), Positives = 129/301 (42%), Gaps = 21/301 (6%)
Query: 62 SSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEM 121
+ +IK +T+ + + K + I YLG ++ + ++ E KL+ E
Sbjct: 589 TEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKET 648
Query: 122 YNQENSVYLSYEKRAETLAVEIKELQGQLADY-NMLVDKLNTNTEMEEVMNDYNMLKAQN 180
Q + + E +A++ + ++ +LA+ + L ++ N +++ D + +A+
Sbjct: 649 LLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAEL 708
Query: 181 DRETQSLDVIFTE-RQAKEKQIR-------SVEEEIEQEKQATDDIIKNMSF--ENQVKY 230
+ D + ++ EK R +++ E+E+E+QA + + F E + +
Sbjct: 709 EARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQEN 768
Query: 231 LEMKTTNEKLLQELDTLQQQL-DSQNMKKESLEAEIAHSQVKQEAVLLHEKLY----ELE 285
E+ + L + + L+QQL D QN ++ + +V L KL E+
Sbjct: 769 SELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMN 828
Query: 286 SHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTD----TKEKINQFIEEIR 341
H + KS+ ++ ++L + K + E ER+L + +EK+ EE R
Sbjct: 829 IHSPSDVL-GKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFR 887
Query: 342 Q 342
Q
Sbjct: 888 Q 888
Score = 48.5 bits (114), Expect = 9e-06
Identities = 68/331 (20%), Positives = 149/331 (45%), Gaps = 66/331 (19%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLA----VEIKELQGQLADYNM- 155
L K +LT E+ KLQK IEM + +L K +E L E+++L+ Q+
Sbjct: 1536 LSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE 1595
Query: 156 --LVDKLNTNTEMEEVMNDYNMLKAQND-------------------RETQSL------- 187
++D+ + + E + +M++A+ D RE +SL
Sbjct: 1596 MAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQ 1655
Query: 188 ----DVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMS-----FENQVKYLE------ 232
+V +ER+ Q+ +++EIE+E++ +++ MS +N + L+
Sbjct: 1656 KGELNVQISERKT---QLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHEL 1712
Query: 233 --MKTTNEKLLQELDTLQQQLDSQNMKKESLE--AEIAHSQVKQEAVLLHEKLYELESHR 288
+K +++ + EL+ Q + + ++ E+L+ ++ +++ + LL E+E
Sbjct: 1713 QGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE--- 1769
Query: 289 DQMIAEDKSIGSPME----EREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLD 344
+M AE +++ S +E E+E L ++ +++A +R L +E + +L+
Sbjct: 1770 -RMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLE 1828
Query: 345 MD---LEEHQDPTNYGWKILEKNTGSFKKQV 372
++ L++ D N L + + ++Q+
Sbjct: 1829 LNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
Score = 45.1 bits (105), Expect = 1e-04
Identities = 50/273 (18%), Positives = 127/273 (46%), Gaps = 15/273 (5%)
Query: 98 LGLLRSKISE---LTTEVNKLQ---KGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLA 151
+G+L + E L EV++L+ + ++ +E + ++++E E++EL +
Sbjct: 1308 MGVLHCNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEK---EMEELHHNID 1364
Query: 152 DYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQE 211
D +L +K + E+EE+ + Q D +++ + TE + EK ++ E+ +++
Sbjct: 1365 D--LLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEI-EKSLKHHEDIVDEI 1421
Query: 212 KQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK 271
+ ++K S + L + +E + T + K+ L+ E +++
Sbjct: 1422 ECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELE 1481
Query: 272 QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKE 331
+ A L + + + A+ K + ++E++LK+I N+ +A+ + +
Sbjct: 1482 RRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEI---NKIVAAKDSDFQCLSK 1538
Query: 332 KINQFIEEIRQLDMDLEEHQDPTNYGWKILEKN 364
K + EE+++L D+E + ++ ++L+++
Sbjct: 1539 KKEKLTEELQKLQKDIEMAERNEDHHLQVLKES 1571
Score = 44.7 bits (104), Expect = 1e-04
Identities = 49/247 (19%), Positives = 108/247 (43%), Gaps = 26/247 (10%)
Query: 102 RSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLN 161
+SK+ ++ ++V ++ + +E S EK ++ E + QL + + + L
Sbjct: 1986 KSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSG--ELLA 2043
Query: 162 TNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKN 221
E + + D+++L+ Q TER+ EKQ+ S++E ++ ++ + KN
Sbjct: 2044 LQKEADSMRADFSLLRNQ----------FLTERKKAEKQVASLKEALKIQRSQLE---KN 2090
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKL 281
+ LE K N + +E+ T++ + + L E+ +Q++ E L +++
Sbjct: 2091 L--------LEQKQENSCIQKEMATIELVAQDNHERARRLMKEL--NQMQYEYTELKKQM 2140
Query: 282 -YELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEI 340
+ + R QM D E ++++ +K+ NQ + + L E+ E+
Sbjct: 2141 ANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGEL 2200
Query: 341 RQLDMDL 347
L +L
Sbjct: 2201 ESLKENL 2207
Score = 38.9 bits (89), Expect = 0.008
Identities = 56/281 (19%), Positives = 121/281 (43%), Gaps = 37/281 (13%)
Query: 99 GLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVD 158
GL+R + E+ V++L++ +++ E +++ ++ L + +LQ Q ++
Sbjct: 802 GLVRPE--EVAARVDELRRKLKLGTGEMNIH----SPSDVLGKSLADLQKQFSE------ 849
Query: 159 KLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI 218
+ ++ E K Q + Q + + + ++ R++E + +K+ +
Sbjct: 850 -ILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEAR 908
Query: 219 IKNMSFENQVKYLEMKTTNEKLLQELDTLQ-QQLDSQNM----------KKESLEAEIAH 267
I+ M EN++ YL+ + + +Q L LQ Q+ D + KK+ LE +
Sbjct: 909 IQQM--ENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQ 966
Query: 268 SQV---------KQEAVLLHEKLY--ELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDN 316
QV ++AV +KL EL +DQ+ + ++ +ER + L++ + +
Sbjct: 967 EQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFS 1026
Query: 317 QEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYG 357
++ A R LT + +I +RQ + T G
Sbjct: 1027 RKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVG 1067
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 58.5 bits (140), Expect = 9e-09
Identities = 59/274 (21%), Positives = 125/274 (45%), Gaps = 23/274 (8%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L+S +LT N L+K E + E + ++L+ L L +L
Sbjct: 2314 LKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRL 2373
Query: 161 NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIK 220
+ M+E ++ + +E I RQ +K+I+ +E + QE++ +
Sbjct: 2374 HEEINMKE----QKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEE------E 2423
Query: 221 NMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVL---- 276
N+ E + K KT +L++ L T++++ Q + +S ++ Q ++ ++
Sbjct: 2424 NIVLEEENKKAVDKT--NQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQ 2481
Query: 277 -LHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDD-NQEIASMERQLTDTKEKIN 334
L E+ + +DQ+I E + + ++E + L+ DD N E A ++ +L +E +N
Sbjct: 2482 QLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLN 2541
Query: 335 QFI-----EEIRQLDMDLEEHQDPTNYGWKILEK 363
Q I ++ + L++ L+++++ N K+ EK
Sbjct: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK 2575
Score = 58.5 bits (140), Expect = 9e-09
Identities = 69/319 (21%), Positives = 143/319 (44%), Gaps = 35/319 (10%)
Query: 56 GTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEV-NK 114
GT G+ +Q+KV V + + Q++I + L ++ + ++ E+ +K
Sbjct: 2625 GTLGLYHAQLKVKEEEVHR-----LSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDK 2679
Query: 115 LQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYN 174
L+K ++ + + + + + AE E+ ++ ++V K N + +
Sbjct: 2680 LKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRS 2739
Query: 175 MLKAQNDRE--TQSLDVIFTERQAKEKQIRSVEEE--IEQEKQATDDIIKNMSFENQVKY 230
M QN R+ + LD + + A K++ ++E+ + +E+ A ++ +F
Sbjct: 2740 MSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDA---LLSETAFS----- 2791
Query: 231 LEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEI--AHSQV----KQEAVLLHEKLY-- 282
M +T E L L+ L QQL S++ + L +++ +++QV K A L +E+ +
Sbjct: 2792 --MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLW 2849
Query: 283 -ELESHRDQMIAEDKSIGSP------MEEREKLLKQIKDDNQEIASMERQLTDTKEKINQ 335
ELE R + +S P ++ +K + +++D + + L +INQ
Sbjct: 2850 NELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
Query: 336 FIEEIRQLDMDLEEHQDPT 354
I E+ L L+E+QD T
Sbjct: 2910 EITELHPLKAQLQEYQDKT 2928
Score = 52.4 bits (124), Expect = 7e-07
Identities = 61/305 (20%), Positives = 135/305 (44%), Gaps = 45/305 (14%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGI-EMYNQENSVYLSYEKRAETLAVEIKEL 146
Q+ I K + L ++SE + K+Q I E + +++ E +A+ IK+L
Sbjct: 1398 QKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQL 1457
Query: 147 QGQLADYNM----------------------LVDKLNTNTEMEEVMNDYNMLKAQNDRET 184
Q +L + L+ + E + + + ++ + +R T
Sbjct: 1458 QVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLT 1517
Query: 185 QSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMS---FENQV---KYLEMKTTNE 238
+SL + ++ A+ K+ +V + ++ D +I M ENQ +K E
Sbjct: 1518 KSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALE 1577
Query: 239 KLLQELDTLQQQLDSQNMKK--ESLEAEIAHSQVKQEAVLLHEKLYEL--ESHRDQMIAE 294
L ++ + L ++++S K ES E + H ++++E +L + + E+ R Q + E
Sbjct: 1578 GLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE 1637
Query: 295 DKSIGSPMEEREKLLKQI-------KDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDL 347
+ +E+++L ++ K+ +++ E+++ + KEK+ +F + +Q ++L
Sbjct: 1638 -----AVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILEL 1692
Query: 348 EEHQD 352
EE D
Sbjct: 1693 EEEND 1697
Score = 51.6 bits (122), Expect = 1e-06
Identities = 61/261 (23%), Positives = 118/261 (45%), Gaps = 33/261 (12%)
Query: 102 RSKISELTTEVN-KLQKGIEMYN-QENSVYLSYEKRAETLAVEIKELQGQLA-------- 151
R S L E+N K QK I + + +E ++ ++ + + EIKEL+ L+
Sbjct: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426
Query: 152 ---DYNMLVDKLNTNTEMEEVMNDYNML-KAQNDRETQSLDVIFTERQAKEKQIRSVEEE 207
+ VDK N E + + N+ KAQ D +S+ + +R + +EE
Sbjct: 2427 LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEER 2486
Query: 208 -----IEQEKQATDDIIKNMSFENQVKYL-----EMKTTNEKLLQELDTLQQQLDSQNMK 257
+E+++ + +N + +++ L ++ + N KL EL ++ L+
Sbjct: 2487 HLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITI 2546
Query: 258 KESLEAEIAHSQVKQEAVL------LHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQ 311
K+S + ++ Q++Q L L EKL E E + + +S + EE++ L K+
Sbjct: 2547 KDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDL---RRSFNALQEEKQDLSKE 2603
Query: 312 IKDDNQEIASMERQLTDTKEK 332
I+ I+ + RQ+T +E+
Sbjct: 2604 IESLKVSISQLTRQVTALQEE 2624
Score = 50.1 bits (118), Expect = 3e-06
Identities = 54/226 (23%), Positives = 100/226 (44%), Gaps = 24/226 (10%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L+ + LT + KL K IE L K AE+ + K + Q +Y +L+
Sbjct: 1572 LKLALEGLTEDKEKLVKEIES--------LKSSKIAESTEWQEKHKELQ-KEYEILLQSY 1622
Query: 161 -NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDII 219
N + E E + + ++ + L ++ EKQ++ E+E+E+ K+
Sbjct: 1623 ENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA 1682
Query: 220 KNMSFENQVKYLEMKTTNEKLLQEL----DTLQQQLDSQNMKKESLEAEIAHSQVKQEAV 275
K+ Q K LE++ N++L E+ DT ++ +++ S++ E+ +VK E
Sbjct: 1683 KS----KQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEEL--ERVKMEYE 1736
Query: 276 LLHEKLYELESHRDQMIAEDKSIGSPME----EREKLLKQIKDDNQ 317
L +K L S +D + E + + +E ++ L K DNQ
Sbjct: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQ 1782
Score = 49.7 bits (117), Expect = 4e-06
Identities = 49/257 (19%), Positives = 117/257 (45%), Gaps = 9/257 (3%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L ++++EL + + + +N + S K + E++E + QL V+
Sbjct: 1926 LMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESE 1985
Query: 161 NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIK 220
+E++ + N + L + E+Q + KQ++ +++ A + +K
Sbjct: 1986 IRKEYLEKIQGAQK--EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVK 2043
Query: 221 NMSFENQVKYLEMKTTNEKLLQELD---TLQQQLDSQNMKKESLEAEIAHSQVKQEAVLL 277
+ F +++ T E L Q ++ Q +L S + + ++E A +V + + L
Sbjct: 2044 ALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAA--RVLADNLKL 2101
Query: 278 HEKLY-ELESHRDQMIAEDKSIGSPMEE-REKLLKQIKDDNQEIASMERQLTDTKEKINQ 335
++L ES + QM +D+ + +E+ EK LK+ K+ +++ ++ R+ +E I +
Sbjct: 2102 KKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGE 2161
Query: 336 FIEEIRQLDMDLEEHQD 352
+ + D ++++ Q+
Sbjct: 2162 IQVTLNKKDKEVQQLQE 2178
Score = 45.1 bits (105), Expect = 1e-04
Identities = 64/323 (19%), Positives = 137/323 (42%), Gaps = 54/323 (16%)
Query: 79 GMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQ---KGIEMYNQENSVYLSYEKR 135
G K+ K Q + +K + L+ +++ L+ K +E E+ L K
Sbjct: 2002 GNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKE 2061
Query: 136 AETLAVEI-KELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTER 194
AVE K+ Q +LA + +L+D +T +E V+ D LK + +S+ ++
Sbjct: 2062 NLAQAVEHRKKAQAELASFKVLLD--DTQSEAARVLADNLKLKKELQSNKESVKSQMKQK 2119
Query: 195 QAK-EKQIRSVEEEIEQEK---QATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQ 250
E+++ EE+ +EK Q D ++ + E++ T K +E+ LQ+
Sbjct: 2120 DEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQEN 2179
Query: 251 LDS-----------------------------QNMKKESLEAEIAHSQVKQE-AVLLHEK 280
LDS + ++++++ ++K++ +L ++
Sbjct: 2180 LDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQ 2239
Query: 281 LYELESHRDQM------IAEDKSIGSPMEEREKLLKQ-----IKDDNQEIASMERQLTDT 329
L ++ H +++ + DK I + E L+Q ++ +N+E+ S QL +T
Sbjct: 2240 LRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLS---QLEET 2296
Query: 330 KEKINQFIEEIRQLDMDLEEHQD 352
+ + E+ +L+ +L+ +D
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKD 2319
Score = 42.7 bits (99), Expect = 5e-04
Identities = 60/281 (21%), Positives = 126/281 (44%), Gaps = 58/281 (20%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
LR ++ + + N+LQ+ + ++EN E + ++++LQ Q+ + +D
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKEN----------ENIGDQLRQLQIQVRES---IDGK 1247
Query: 161 NTNTEMEEVMN-----DYNMLKAQNDRETQ--------------SLDVIFTERQAKEKQI 201
+T+ +E + + + KA TQ S D + QI
Sbjct: 1248 LPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI 1307
Query: 202 RSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESL 261
++ +EIE EK E ++K + K +E+ LQ+Q++ Q ++ ESL
Sbjct: 1308 KAQLKEIEAEK-----------VELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESL 1356
Query: 262 EAEIAHSQVKQEAVLLHEKLYELESHRDQMIAED--KSIGSPMEEREKLLKQIKDD---- 315
+ ++V E+ L +K LES + Q+ + + + ++E +KL+ + ++D
Sbjct: 1357 KTVSHEAEVHAES--LQQK---LESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYL 1411
Query: 316 NQEIASMERQLTDTKEKINQFIEEIR----QLDMDLEEHQD 352
+ +++ E LT + +I + + I+ QL+M +EH +
Sbjct: 1412 SGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE 1452
Score = 42.4 bits (98), Expect = 7e-04
Identities = 58/309 (18%), Positives = 138/309 (44%), Gaps = 46/309 (14%)
Query: 71 PVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYL 130
P Q L + + + ++L + L +I++ TE++ L+ ++ Y +
Sbjct: 2873 PAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTK--- 2929
Query: 131 SYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVI 190
+++ E L E Q +L + + ++K + + Y M + D++ L +
Sbjct: 2930 AFQIMQEELRQENLSWQHEL--HQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNL 2987
Query: 191 FTERQAKEKQIRSVEEEIEQ----EKQATDDIIKNMSFENQV--------------KYLE 232
E ++ Q + ++ + ++ E A+ D +N+ +E ++ K L
Sbjct: 2988 IRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELR 3047
Query: 233 MKTTNE---KLLQELDTLQQQL--DSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESH 287
++ N +LL+E +TL QL SQ+++ E + + + +L +++ EL++
Sbjct: 3048 IQQLNSNFSQLLEEKNTLSIQLCDTSQSLR----ENQQHYGDLLNHCAVLEKQVQELQAG 3103
Query: 288 RDQMIAEDKSIGSPMEE----REKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQL 343
+ D + G+P E+ R+ +++++ Q + ++QL +T++++N+ L
Sbjct: 3104 PLNI---DVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNE-------L 3153
Query: 344 DMDLEEHQD 352
LEE +D
Sbjct: 3154 RKLLEEERD 3162
Score = 40.4 bits (93), Expect = 0.003
Identities = 78/400 (19%), Positives = 155/400 (38%), Gaps = 119/400 (29%)
Query: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIE 120
+SS+++ + ++Q+ L K + +L+K + L+ I E +V ++ +
Sbjct: 857 ISSKVEELSQALSQKELEITKM-----DQLLLEKKRDVETLQQTIEEKDQQVTEISFSMT 911
Query: 121 MYNQENSVYLSYEKRAETLAVEIKELQGQL--------------ADYNMLVDKLNTNTE- 165
E V L+ EK + L VEIK L+ QL + N + L N +
Sbjct: 912 ----EKMVQLNEEKFS--LGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDE 965
Query: 166 --------MEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEE----------- 206
EE+ +++++LK +N++ + L R+ +++ +EE
Sbjct: 966 MSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKK 1025
Query: 207 ----------EIEQEK--------------QATDDIIKNMSFENQV------KYLEMKTT 236
E+E++K Q + +K E +V K LE K
Sbjct: 1026 EIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLA 1085
Query: 237 NEKLLQEL-DTLQQQLDSQNMKKESLEAEIAHSQ---------------------VKQEA 274
E+ Q L + Q L + + + L+AEI+ +Q VK+
Sbjct: 1086 AEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETV 1145
Query: 275 VL--------------LHEKLYELESHRDQM-------IAEDKSIGSPMEEREK-LLKQI 312
V+ L EK+ LE ++Q+ + K+I +E+E+ L +++
Sbjct: 1146 VISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREEL 1205
Query: 313 KDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQD 352
K + ++ Q + ++ +++RQL + + E D
Sbjct: 1206 KQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESID 1245
Score = 38.1 bits (87), Expect = 0.013
Identities = 44/236 (18%), Positives = 98/236 (41%), Gaps = 30/236 (12%)
Query: 132 YEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIF 191
++ E L +I EL+ + +K N + + +E+ N N L + + + F
Sbjct: 682 HQDELERLKSQILELELNFHKAQEIYEK-NLDEKAKEISN-LNQLIEEFKKNADNNSSAF 739
Query: 192 TERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEM---------------KTT 236
T + Q+ S +E+ + QVK LEM +T
Sbjct: 740 TALSEERDQLLSQVKELSMVTE----------LRAQVKQLEMNLAEAERQRRLDYESQTA 789
Query: 237 NEKLL-QELDTLQQQLDSQNMKKESLEAEI--AHSQVKQEAVLLHEKLYELESHRDQMIA 293
++ LL +++ +L + S+++K E L+ E+ Q +++ L+ +L++ +++
Sbjct: 790 HDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLE 849
Query: 294 EDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEE 349
+ + + E+L + + EI M++ L + K + + I + D + E
Sbjct: 850 GAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTE 905
Score = 37.4 bits (85), Expect = 0.022
Identities = 45/252 (17%), Positives = 109/252 (43%), Gaps = 47/252 (18%)
Query: 136 AETLAVEIKEL-----------------QGQLADYNMLVDKLNTNTEMEEVMNDYNMLKA 178
AE L VE+K++ + + AD + KL+ ++ + +KA
Sbjct: 57 AEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKA 116
Query: 179 QNDRETQSLDVIFTERQAKEKQIR----SVEEEIEQEK-----QATDDIIKNMSFENQVK 229
Q V+ TE Q++E+ + S EEE+E EK Q +++I + +
Sbjct: 117 QGGT------VLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQA 170
Query: 230 YLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHS-------QVKQEAVLLHEKLY 282
E + ++E ++QQL + +L+A+++ + QV +E E
Sbjct: 171 QAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQV 230
Query: 283 ELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQE--------IASMERQLTDTKEKIN 334
L + + + M+++ ++L++ ++++E + ++++LT +++
Sbjct: 231 RLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQ 290
Query: 335 QFIEEIRQLDMD 346
++++Q++ +
Sbjct: 291 ILSQQLQQMEAE 302
Score = 35.8 bits (81), Expect = 0.064
Identities = 54/293 (18%), Positives = 121/293 (41%), Gaps = 45/293 (15%)
Query: 101 LRSKISELTTEVNKLQKGIE----MYNQENSVYLSYEKRAETLAVEIKELQGQLADYNML 156
L+ ISE E+ ++K +E Q ++ + + +I LQ ++++ +
Sbjct: 1062 LKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAI 1121
Query: 157 VDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATD 216
+ KL T+ + ++K + E++I ++E+E EQ ++
Sbjct: 1122 IQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQ 1181
Query: 217 DIIKNMSFENQVKYLEMKTTNEKLLQELDT---LQQQLDSQNMKKESLEAEIAHSQVKQE 273
+ + + + + + E+L Q+ D LQ+Q D Q+ + E++ ++ Q++
Sbjct: 1182 EALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVR 1241
Query: 274 AVL------------------LHEKLYE-LESHRDQMI------------AEDKSI---G 299
+ L E L++ E H Q + +ED S G
Sbjct: 1242 ESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGG 1301
Query: 300 SPMEEREKLLKQIKDDNQE----IASMERQLTDTKEKINQFIEEIRQLDMDLE 348
+ + + + LK+I+ + E ++S +LT E++ Q E+I + +++E
Sbjct: 1302 TSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIE 1354
Score = 34.7 bits (78), Expect = 0.14
Identities = 54/284 (19%), Positives = 120/284 (42%), Gaps = 33/284 (11%)
Query: 100 LLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDK 159
+L ++ ++ E N L+ +E +E+ + L +E++ + +L+ +N+ +
Sbjct: 291 ILSQQLQQMEAEHNTLRNTVETEREESKILLE--------KMELEVAERKLSFHNLQEEM 342
Query: 160 LNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDII 219
+ + E+ L+++ Q E + K I S+++ QE Q+ D +
Sbjct: 343 HHLLEQFEQAGQAQAELESRYSALEQKHKA---EMEEKTSHILSLQKT-GQELQSACDAL 398
Query: 220 KNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHE 279
K+ + K L+ K NE+ +Q T+QQ D K + + + ++Q
Sbjct: 399 KDQNS----KLLQDK--NEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQT 452
Query: 280 KLYELESHRDQMIAED------KSIGSPMEEREKL------LKQIKDDNQEIASMERQL- 326
++ + Q + E+ K + E+ L L+++K +N++++S L
Sbjct: 453 SFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLE 512
Query: 327 -TDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFK 369
+ + ++ + EI +D+ + G +LE NT S K
Sbjct: 513 AQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLE-NTFSQK 555
Score = 33.1 bits (74), Expect = 0.41
Identities = 37/190 (19%), Positives = 83/190 (43%), Gaps = 27/190 (14%)
Query: 188 DVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTL 247
+V+ E + +++ ++ E D+ N + + V+ E E+L+ EL +
Sbjct: 10 NVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQ--ERLAYAEQLVVELKDI 67
Query: 248 QQQLDSQNMKKESL---EAEIAHSQVKQEAVLLHEKLYELESHRDQMIAE---------- 294
+Q D Q +K+ E + A +++K+ + KL L + ++M A+
Sbjct: 68 IRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQ 127
Query: 295 --------DKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTK----EKINQFIEEIRQ 342
DKS E EK+ ++++ + I++++ QLT + + + +EE
Sbjct: 128 SEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVM 187
Query: 343 LDMDLEEHQD 352
+ L+E ++
Sbjct: 188 MKQQLQEKEE 197
Score = 32.7 bits (73), Expect = 0.54
Identities = 55/301 (18%), Positives = 118/301 (39%), Gaps = 36/301 (11%)
Query: 80 MKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNK-----LQKGIEMYNQENSVYLSYE- 133
M+ K Q++IL+ LR+++ + L M + V + YE
Sbjct: 1678 MRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYET 1737
Query: 134 --KRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIF 191
K+ ++L E L ++ D ++ + E ++ + TQS+
Sbjct: 1738 LSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGET 1797
Query: 192 TERQAKEKQIR-SVEEEIEQEKQATDDIIKNMSFENQVK-YLEM---------------- 233
E+ + R + E + K A + K+ S +++ YL+
Sbjct: 1798 EEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQ 1857
Query: 234 --KTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQM 291
K ++ L E +TL Q+ +++ + + L+ E+ LL++++ E S ++
Sbjct: 1858 KNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMN------LLNQQIQEELSRVTKL 1911
Query: 292 IAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ 351
+ +EER L+ Q+ + N I + + +TD + K E++ L + E +
Sbjct: 1912 KETAEEEKDDLEER--LMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELE 1969
Query: 352 D 352
+
Sbjct: 1970 E 1970
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 58.2 bits (139), Expect = 1e-08
Identities = 67/289 (23%), Positives = 133/289 (46%), Gaps = 54/289 (18%)
Query: 102 RSKISELTTEVNKLQKGIEMYNQENSVYL---SYEKRAETLAVEIKELQGQLADYNMLVD 158
R ++ ELT++ KLQ +M + L + E+++++ V+ K L A +N L
Sbjct: 1871 RVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEF 1930
Query: 159 KL--------NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQ 210
KL E+ + D ML+ ++ +E + L + Q +E++I+ +E++E
Sbjct: 1931 KLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYD--QEREEKIKQEQEDLEL 1988
Query: 211 EKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQV 270
+ +T +K L M+ N +L Q+ L+ + K + +EAE+ S
Sbjct: 1989 KHNST------------LKQL-MREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQ 2035
Query: 271 KQEAVLLHE------------KLYE--LESHRDQMIAEDKSIGSPMEEREKLLKQIKD-- 314
++ LL + K YE L++ ++M A+ + + + +EE +K +Q +
Sbjct: 2036 EETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQE 2095
Query: 315 -----DNQEIASMERQL-------TDTKEKINQFIEEIRQLDMDLEEHQ 351
DN I ++ QL +D+K K +F E+I L+ L++++
Sbjct: 2096 ENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYE 2144
Score = 52.4 bits (124), Expect = 7e-07
Identities = 57/259 (22%), Positives = 118/259 (45%), Gaps = 45/259 (17%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNML-VDK 159
L I++ T E+ L + ++ YNQ+ + E KEL +L + L +K
Sbjct: 1530 LEDHITQKTIEIESLNEVLKNYNQQKDI-------------EHKELVQKLQHFQELGEEK 1576
Query: 160 LNTNTEMEEVM----NDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQAT 215
N E EE + N +KA+ + + + L+ + ++KE++++++E+ +E E A
Sbjct: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAA- 1635
Query: 216 DDIIKNMSFENQVKYLEMKTTNEKLLQEL--DTLQQQLDSQNMKKESLEAEIAHSQVK-- 271
K E+K E+ + + L Q + + K+ E+ ++ K
Sbjct: 1636 -------------KLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQ 1682
Query: 272 ---QEAVLLHEKLYELESHRDQMI-----AEDKSIGSPMEEREKLLKQIKDDNQEIASME 323
+E +L EKL +ES + + + A++ + + EE + K ++I+ ++
Sbjct: 1683 EREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQ 1742
Query: 324 RQLTDTKEKINQFIEEIRQ 342
R LT+ KEK+ Q + + ++
Sbjct: 1743 RNLTE-KEKLLQRVGQEKE 1760
Score = 48.1 bits (113), Expect = 1e-05
Identities = 57/263 (21%), Positives = 117/263 (44%), Gaps = 23/263 (8%)
Query: 98 LGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLV 157
L R K SEL T LQ+ E + + S +K +A +ELQ L
Sbjct: 150 LSSYRGKYSELVTAYQMLQR--EKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQ 207
Query: 158 DKLNTNTEMEE-----VMNDYNMLKAQNDRETQSLDVIFTERQAK-EKQIRSVEEEIEQE 211
++ + + E ++ + ++LK + ++DV+ Q + + ++ + EE E +
Sbjct: 208 EEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESD 267
Query: 212 KQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVK 271
+ E+ ++T +++ ++ + L++ ++ KE + +
Sbjct: 268 GEPV--------VEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEAL 319
Query: 272 QEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDD-NQEIASMERQLTDT- 329
QE L E+L ELE +D +AE + + + + + L++Q++ D IA +RQ+ +T
Sbjct: 320 QEQ--LDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETL 377
Query: 330 ---KEKINQFIEEIRQLDMDLEE 349
+E+I Q I+Q+ EE
Sbjct: 378 EMKEEEIAQLRSRIKQMTTQGEE 400
Score = 47.4 bits (111), Expect = 2e-05
Identities = 56/283 (19%), Positives = 131/283 (46%), Gaps = 28/283 (9%)
Query: 84 TKGPQRQILD-KSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVE 142
TK + L+ K + LRS+I ++TT+ +L++ E E + + EK T A +
Sbjct: 369 TKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKE--KSERAAFEELEKALST-AQK 425
Query: 143 IKELQGQL-ADYNMLVDKLNTNTEMEEVMNDYNMLKAQND----RETQSLDVIFTERQAK 197
+E + +L A+ + + + +E E + + + + + + S + I ++
Sbjct: 426 TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLH 485
Query: 198 EKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQ---LDSQ 254
EK++ E+E+ ++ Q + F+ Q+K K+ +E L + QQ+ L+
Sbjct: 486 EKELARKEQELTKKLQT-----REREFQEQMKVALEKSQSEYLKISQEKEQQESLALEEL 540
Query: 255 NMKKESL--EAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPM---------E 303
++K+++ E+E ++QEA ++ ELES ++ + E+K+ + +
Sbjct: 541 ELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600
Query: 304 EREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMD 346
+++ ++ E+ S++ Q + Q +++ Q +M+
Sbjct: 601 HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEME 643
Score = 47.0 bits (110), Expect = 3e-05
Identities = 70/337 (20%), Positives = 144/337 (42%), Gaps = 57/337 (16%)
Query: 63 SQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKG---- 118
S+++ R +T++ T + + Q+ +K + +++ I L TE LQK
Sbjct: 1272 SELEAQLRQLTEEQNT-LNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQ 1330
Query: 119 ---------------IEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN 163
E+ N+V L E+ E VEI L QL D N+ + +
Sbjct: 1331 QQAASEKESCITQLKKELSENINAVTLMKEELKEK-KVEISSLSKQLTDLNVQLQNSISL 1389
Query: 164 TEMEEVMNDYNMLKAQNDRETQSL-----DVIFTERQAKEKQIRSVEEEIEQEKQATDDI 218
+E E ++ L+ Q D E L D+ F +++I ++E+ + + ++
Sbjct: 1390 SEKEAAISS---LRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK 1446
Query: 219 IKNMS----FENQVKYLEM------KTTNEKLLQELDTLQQQLDSQNMKKESLEAEI--- 265
K S +N VK L++ K EK ++++ L+++LD QN + + L+ E+
Sbjct: 1447 KKAQSRFTQHQNTVKELQIQLELKSKEAYEKD-EQINLLKEELDQQNKRFDCLKGEMEDD 1505
Query: 266 ------AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPME--------EREKLLKQ 311
S ++ E ++ ELE H Q E +S+ ++ E ++L+++
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQK 1565
Query: 312 IKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLE 348
++ + + ++ + +EKI ++ + +LE
Sbjct: 1566 LQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELE 1602
Score = 47.0 bits (110), Expect = 3e-05
Identities = 66/295 (22%), Positives = 129/295 (43%), Gaps = 38/295 (12%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAV---EIK 144
Q ++ +K+ L+ ++ E N +Q + N + V + +++ T + +IK
Sbjct: 1798 QEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIK 1857
Query: 145 ELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEK-QIRS 203
EL D ++ K EMEE+ + Y L+A + ++ E +EK +
Sbjct: 1858 EL-----DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHL 1912
Query: 204 VEEEI--EQEKQATDDIIKNMSFENQVKYL---------EMKTTNEKLLQELDTLQQQLD 252
V+ ++ E Q D K E + + L +++ ++ QEL+ L+++ D
Sbjct: 1913 VQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYD 1972
Query: 253 ---SQNMKKESLEAEIAHSQVKQEAV-----LLHEKLYELESHRDQMI-----AEDKSIG 299
+ +K+E + E+ H+ ++ + L +K ELE + I E + +
Sbjct: 1973 QEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLE 2032
Query: 300 SPMEEREKLLKQI---KDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ 351
S EE +LLK+I DD + A ++ D +E+ + ++R L LEE Q
Sbjct: 2033 SHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE--EMTAKVRDLQTQLEELQ 2085
Score = 42.7 bits (99), Expect = 5e-04
Identities = 60/288 (20%), Positives = 128/288 (44%), Gaps = 42/288 (14%)
Query: 102 RSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAE----TLAVE--------IKELQGQ 149
R++I EL + + K + + +++ +V+L EK T+ VE +K Q
Sbjct: 566 RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA 625
Query: 150 LADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRET--QSLDVIFTERQAKEKQIRSVEEE 207
L + V K TEME++ K + ++ET + ++IF + I + E+
Sbjct: 626 LWTEKLQVLKQQYQTEMEKLRE-----KCEQEKETLLKDKEIIF------QAHIEEMNEK 674
Query: 208 IEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKES-LEAEIA 266
++ ++++S E E+ KL +EL L+ Q D + E+ ++ +
Sbjct: 675 TLEKLDVKQTELESLSSELS----EVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730
Query: 267 HSQVKQEAVLLHEKLYELESHRDQMIAEDK--SIGSPMEEREKLLKQIKDDNQEIASMER 324
H Q + ++++ K +E+ R + +D+ + ++ER+K LK+ + A +E
Sbjct: 731 HHQQQVDSII---KEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQ------AHVEN 781
Query: 325 QLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKKQV 372
D K + + +LD+ + +Q T+ K E+ ++++
Sbjct: 782 LEADIKRSEGELQQASAKLDV-FQSYQSATHEQTKAYEEQLAQLQQKL 828
Score = 42.0 bits (97), Expect = 9e-04
Identities = 53/281 (18%), Positives = 116/281 (41%), Gaps = 47/281 (16%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
Q Q+ KS ++ L ++L + KL+ + +EN+ + LA E K
Sbjct: 1112 QEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKV 1171
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEE 207
+L KL T E ++ LK+ +++ +SL+ K + + + EE
Sbjct: 1172 SELTS------KLKTTDE------EFQSLKSSHEKSNKSLE-------DKSLEFKKLSEE 1212
Query: 208 IEQE------------KQATDDII-----KNMSFENQVKYLEMKTTNEKLLQELDTLQQQ 250
+ + + T+++I K + +++ + + +TT K +
Sbjct: 1213 LAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVK---------EA 1263
Query: 251 LDSQNMKKESLEAEIAHSQVKQEA--VLLHEKLYELESHRDQMIAEDKSIGSPMEEREKL 308
L + LEA++ +Q + + ++LE +Q+ + I S + E+E L
Sbjct: 1264 LLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL 1323
Query: 309 LKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEE 349
K+ + Q + E +T K+++++ I + + +L+E
Sbjct: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE 1364
Score = 40.4 bits (93), Expect = 0.003
Identities = 53/278 (19%), Positives = 122/278 (43%), Gaps = 32/278 (11%)
Query: 101 LRSKISELTTEVNKLQKGIE--MYNQENSVYLSYEKRAETLAVEI----KELQGQLADYN 154
L ++S L + +K+++ +E M Q+N + + V I K L+ Q+
Sbjct: 703 LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
Query: 155 MLVDKLNTNTE-----MEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIE 209
+L+ + + + + +E + D + + + + LDV + + A +Q ++ EE++
Sbjct: 763 LLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLA 822
Query: 210 QEKQATDDI-IKNMSFENQVKYLEMKTTNEKLLQELDT-------LQQQLDSQNMKKE-- 259
Q +Q D+ + + QV E++ + + ELD L QQL+ QN + E
Sbjct: 823 QLQQKLLDLETERILLTKQV--AEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQK 880
Query: 260 --------SLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQ 311
+ E + + +Q +L EK + R+ E + + + +E +
Sbjct: 881 VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI 940
Query: 312 IKDDNQ-EIASMERQLTDTKEKINQFIEEIRQLDMDLE 348
+ ++ + + + E+++ K+K + E +++ +D E
Sbjct: 941 LNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQE 978
Score = 39.7 bits (91), Expect = 0.004
Identities = 65/339 (19%), Positives = 136/339 (40%), Gaps = 76/339 (22%)
Query: 101 LRSKISELTTEV-NKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDK 159
+ K+ LT +KL+ G + QE + + EK E + ++++E GQ + +L K
Sbjct: 877 MEQKVKSLTQVYESKLEDGNK--EQEQTKQILVEK--ENMILQMRE--GQKKEIEILTQK 930
Query: 160 LNTNTEMEEVMNDYNMLKAQND--------------RETQSLDVIFTERQAKEKQIRSVE 205
L+ + ++N+ K +N +ET ++ E + K++ +
Sbjct: 931 LSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTAL 990
Query: 206 EEIEQEKQ--------------ATDDIIKNMSFENQVKYLEMKTT-------------NE 238
E ++EKQ D + + NQ + +E T +
Sbjct: 991 ELSQKEKQFNAKMLEMAQANSAGISDAVSRLE-TNQKEQIESLTEVHRRELNDVISIWEK 1049
Query: 239 KLLQELDTLQQQLDSQNMKKESLEAE---------------------IAHSQVKQEAVL- 276
KL Q+ + LQ+ + Q +KE AE + VKQ+ L
Sbjct: 1050 KLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLN 1109
Query: 277 -LHEKLYELESHRDQMIAEDKSIGSPMEERE-KLLKQIKDD---NQEIASMERQLTDTKE 331
L E+L + +H + + ++ + + +E+ E L K +K++ +++ ++ + K
Sbjct: 1110 ELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169
Query: 332 KINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKK 370
K+++ +++ D + + + K LE + FKK
Sbjct: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK 1208
Score = 32.7 bits (73), Expect = 0.54
Identities = 42/214 (19%), Positives = 95/214 (44%), Gaps = 15/214 (7%)
Query: 163 NTEMEEVMNDYNML-KAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKN 221
++E E+++ + + L K Q + + ++ + + K ++ + + +++EK+ I+
Sbjct: 121 DSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQ 180
Query: 222 MSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKES----LEAEIAHSQVKQEA--- 274
++ + E++ + Q LQ++ D+ +K+ L+ ++ S +KQ
Sbjct: 181 SQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQV--SLLKQRLRNG 238
Query: 275 ---VLLHEKLYELESHRDQMIAED--KSIGSPMEEREKLLKQIKDDNQEIASMERQLTDT 329
V + + L +LE + E+ +S G P+ E +K ++ Q + E L
Sbjct: 239 PMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRC 298
Query: 330 KEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEK 363
KE I E+ L + E Q+ + + LEK
Sbjct: 299 KETIQSHKEQCTLLTSEKEALQEQLDERLQELEK 332
Score = 31.6 bits (70), Expect = 1.2
Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 2/83 (2%)
Query: 97 YLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNML 156
Y +L ++ E+T +V LQ +E ++ L E+ V I ELQ QLA L
Sbjct: 2059 YEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTL 2118
Query: 157 V--DKLNTNTEMEEVMNDYNMLK 177
+ KL E++ N + LK
Sbjct: 2119 ISDSKLKEQEFREQIHNLEDRLK 2141
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 58.2 bits (139), Expect = 1e-08
Identities = 58/274 (21%), Positives = 127/274 (46%), Gaps = 39/274 (14%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
+ ++ +K+ L L S +SEL + LQ+ ++ S EK ++ L++ EL+
Sbjct: 2006 EAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQ----------SLEKDSQALSLTKCELE 2055
Query: 148 GQLADYNMLVDKLNTNTEMEEVM---NDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSV 204
Q+A N + L +E + +DY L +++L+ E+ ++ S
Sbjct: 2056 NQIAQLNKEKELLVKESESLQARLSESDYEKLNV-----SKALEAALVEKGEFALRLSST 2110
Query: 205 EEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAE 264
+EE+ Q ++ + + + + + + + ++L +++ DS K E+LE E
Sbjct: 2111 QEEVHQLRRGIEKLRVRIEADEKKQL--------HIAEKLKERERENDSLKDKVENLERE 2162
Query: 265 IAHSQVKQEAVLL--HEKLYELESHRDQMIAEDKSIG-------SPMEEREKLLKQIKDD 315
+ S+ QE V+L E+E+ + Q+ +S+ + E+E L KQI++
Sbjct: 2163 LQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEK 2222
Query: 316 NQEIASMERQLTDTKEKINQFIEEIRQLDMDLEE 349
+++ +++ L+ K +EE Q ++ ++E
Sbjct: 2223 QGQLSELDKLLSSFK----SLLEEKEQAEIQIKE 2252
Score = 53.9 bits (128), Expect = 2e-07
Identities = 60/280 (21%), Positives = 138/280 (49%), Gaps = 28/280 (10%)
Query: 111 EVNKLQKGIEMYNQEN----SVYLSYEKRAETLAVEIKELQGQLADYNM-LVDKLNTNTE 165
+++ LQ ++ + EN V +++ E+L E+KEL +L + L+ K+ E
Sbjct: 1768 DIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIE 1827
Query: 166 MEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEE-----EIEQEKQATDDIIK 220
+E+++ + LK +N ++ L+ + Q +++ + E E+ +K + +DI
Sbjct: 1828 LEKIVGE---LKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGD 1884
Query: 221 NMSFEN---QVKYLEMKTT-----NEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQ 272
N++ N + ++L+++ +EK E + L + D + ++ E L E + ++
Sbjct: 1885 NVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQK 1944
Query: 273 EAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQ----LTD 328
V L E+L + S R+Q+ E ++ ++L +++K+ QE+ S + + +
Sbjct: 1945 VIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQV 2004
Query: 329 TKEKINQFIEEIRQLDMDLEE-HQDPTNYGWKI--LEKNT 365
+ ++ + E ++ L D+ E +D T+ K+ LEK++
Sbjct: 2005 AEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDS 2044
Score = 49.7 bits (117), Expect = 4e-06
Identities = 66/281 (23%), Positives = 129/281 (45%), Gaps = 33/281 (11%)
Query: 90 QILDKSYYLGLLRSKISELTTEVNKLQKG--IEMYNQENSVYLSYEKRAETLAVEIKELQ 147
++L SY K E E+ K+ K +E N+ + ++ +A + ELQ
Sbjct: 2584 EVLQSSY-------KNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQ 2636
Query: 148 GQLA-DYNMLVDKLNTNTEMEEVMNDYNMLKA---QNDRETQSLDVIFTERQAKEKQIRS 203
+L+ + N L +L +EE+ + + LK +N +SLD + ++ KE ++R
Sbjct: 2637 EELSGEKNRLAGELQLL--LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVRE 2694
Query: 204 VEEEIEQEKQATDDIIKNMSFENQVKY-LEMKTTNEKLLQELDTLQQQ---LDSQNMKKE 259
E + + + + + +Y +E++T EKL + + L Q +D KE
Sbjct: 2695 EIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKE 2754
Query: 260 SLEAEI-AHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQE 318
L + A +Q+ +E L K+ L+ + +Q+ E++ M+ K KQ++++ +
Sbjct: 2755 ELNNSLKATTQILEE--LKKTKMDNLK-YVNQLKKENERAQGKMKLLIKSCKQLEEEKEI 2811
Query: 319 I--------ASMERQLTDT--KEKINQFIEEIRQLDMDLEE 349
+ A+ E+Q T T K+++ EI++L LEE
Sbjct: 2812 LQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEE 2852
Score = 47.0 bits (110), Expect = 3e-05
Identities = 61/302 (20%), Positives = 128/302 (42%), Gaps = 37/302 (12%)
Query: 87 PQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAET-------- 138
P R+ SY+ G S T ++ K ++ +S +L + +A+
Sbjct: 236 PIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKIN 295
Query: 139 -----LAVEIKELQGQLADYNMLVDKLN-TNTEMEEVMNDYNMLKAQNDRETQSLDVIFT 192
L KE++GQ+ + L +L E+ E N + + R T D T
Sbjct: 296 ELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQAST 355
Query: 193 ERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLD 252
+ A E++++ + E++ ++Q + S E ++K EK QE + +QQ
Sbjct: 356 KYTALEQKLKKLTEDLSCQRQNAESA--RCSLEQKIK------EKEKEFQE-ELSRQQRS 406
Query: 253 SQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEE-REKLLK- 310
Q + +E ++ + +Q Q+A +H L++ D++ + + + + +EE ++KL +
Sbjct: 407 FQTLDQECIQMKARLTQELQQAKNMHN---VLQAELDKLTSVKQQLENNLEEFKQKLCRA 463
Query: 311 -------QIKDD--NQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKIL 361
QIK++ + + M+++ K Q E+ L+ +L+ + N
Sbjct: 464 EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523
Query: 362 EK 363
E+
Sbjct: 524 EE 525
Score = 45.4 bits (106), Expect = 8e-05
Identities = 62/316 (19%), Positives = 129/316 (40%), Gaps = 67/316 (21%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKE--------LQGQLAD 152
+RS+ LT E+ K Q+ I NS + + + E V++KE LQ QL +
Sbjct: 2390 IRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKE 2449
Query: 153 YNMLVDKLNTNTE--------------------------MEEVMNDYNMLKAQNDRETQS 186
N V L+ + E ++E N+Y +L++ + Q
Sbjct: 2450 LNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQE 2509
Query: 187 LDVIFTERQAKEKQIRSVEEEIEQEKQATDDI----------------IKNMSFENQVKY 230
++ + + K+++I ++ +I+ ++Q + ++N++ E + K
Sbjct: 2510 VEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKI 2569
Query: 231 LEMKTTNEKLLQELDTLQQ-------QLDSQNMKKESLEAEIAHSQVKQEAVL--LHEKL 281
+++ N L L+ LQ +L+ M K S ++ K+ + +HE
Sbjct: 2570 QVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMA 2629
Query: 282 Y-------ELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEI-ASMERQLTDTKEKI 333
EL ++++ E + + ++ + LK++ +N E+ S++ D EK
Sbjct: 2630 QKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKE 2689
Query: 334 NQFIEEIRQLDMDLEE 349
+ EEI + + L E
Sbjct: 2690 GKVREEIAEYQLRLHE 2705
Score = 45.1 bits (105), Expect = 1e-04
Identities = 61/267 (22%), Positives = 126/267 (47%), Gaps = 33/267 (12%)
Query: 93 DKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLAD 152
+ S + L + +I ELT E L++ NQE ++ +++E+ A I E + +++
Sbjct: 957 EMSSIISLNKREIEELTQENGTLKEINASLNQEK---MNLIQKSESFANYIDEREKSISE 1013
Query: 153 YN--MLVDKLNTNTEMEEVMNDYNML----KAQNDRETQSLDVIFTERQAKEKQIRSVEE 206
+ +KL EE N Y L KA ++ ++ L+ + E + + +
Sbjct: 1014 LSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSK-LECLLNECTSL---CENRKN 1069
Query: 207 EIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIA 266
E+EQ K+A ++ F ++ + E + N+ L+ EL+T+QQ L S+ +
Sbjct: 1070 ELEQLKEAFAK--EHQEFLTKLAFAEER--NQNLMLELETVQQALRSEMTDNQ------- 1118
Query: 267 HSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKD----DNQEIASM 322
+ K EA L +++ L+ +++M K + ++E E+L+K +K N E +
Sbjct: 1119 -NNSKSEAGGLKQEIMTLKEEQNKM---QKEVNDLLQENEQLMKVMKTKHECQNLESEPI 1174
Query: 323 ERQLTDTKEKINQFIEEIRQLDMDLEE 349
+ + + + NQ Q+D++++E
Sbjct: 1175 RNSVKERESERNQ-CNFKPQMDLEVKE 1200
Score = 44.3 bits (103), Expect = 2e-04
Identities = 67/319 (21%), Positives = 128/319 (40%), Gaps = 73/319 (22%)
Query: 103 SKISELTTEVNKLQKGIEMYNQE-NSVYLSYEKRAETLAVEIKELQG------QLADYNM 155
+K + L ++ KL + + Q S S E++ + E +E Q D
Sbjct: 355 TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQEC 414
Query: 156 LVDKLNTNTEMEEVMNDYNMLKAQNDRETQ-----------------SLDVIFTERQAKE 198
+ K E+++ N +N+L+A+ D+ T + F Q KE
Sbjct: 415 IQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE 474
Query: 199 KQIRSVEEEIEQEK-----------------QATDDIIKNMSFENQVKYLEMKTTNEKLL 241
++R EE+++E +A IK ++Q EMK N
Sbjct: 475 NELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQE 534
Query: 242 QELDTLQQQLDSQ--NMKKESLEAEIAHSQVKQEAV--LLHEKLYELESHRDQMI---AE 294
L LQ++++ Q ++ E L+ +A + +++ LL ++ + +E D++ E
Sbjct: 535 TMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKE 594
Query: 295 DKSIGSPME---------------------EREKLLKQIKDDNQEIAS----MERQLTDT 329
K++ S +E E EKLL Q++ + + + S +E L
Sbjct: 595 SKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 654
Query: 330 KEKINQFIEEIRQLDMDLE 348
+ K +++ E +R L+MD E
Sbjct: 655 QIKSHEYNERVRTLEMDRE 673
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/173 (23%), Positives = 87/173 (50%), Gaps = 18/173 (10%)
Query: 187 LDVIFTERQAKEKQIRSVEEEIEQEKQATDDII---KNMSFENQVKYLE----MKTTNEK 239
LD + E+Q ++ Q+ S+E ++++KQ ++ N+ ENQ + +E ++ T +K
Sbjct: 27 LDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQ-RLMEICESLEKTKQK 85
Query: 240 LLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIG 299
+ EL + Q++ Q + S + +I +++QE K + E R Q A+ +
Sbjct: 86 ISHELQVKESQVNFQEGQLNSGKKQI--EKLEQEL-----KRCKSELERSQQAAQSADVS 138
Query: 300 -SPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ 351
+P +K+ +Q + + + D KEK N+ +EE ++L+ +++ Q
Sbjct: 139 LNPCNTPQKIFTTPLTPSQYYSGSKYE--DLKEKYNKEVEERKRLEAEVKALQ 189
Score = 40.0 bits (92), Expect = 0.003
Identities = 56/255 (21%), Positives = 108/255 (42%), Gaps = 43/255 (16%)
Query: 99 GLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEK--------RAETLAVEIKELQGQL 150
G L+ +I L E NK+QK + QEN + K +E + +KE + +
Sbjct: 1126 GGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESER 1185
Query: 151 ADYNMLVDKLNTNTEMEEV-MNDYN----MLKAQNDRETQSLDVIFTERQAKEKQIRSVE 205
N K + E++E+ ++ YN L+A + L E++ + +++++
Sbjct: 1186 NQCNF---KPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIR 1242
Query: 206 EEIE----QEKQATD-DIIKNMSFENQVKYL----EMKTT---NEKLLQELDTLQQQLDS 253
++E Q+ Q+ + +K+ + + KY+ E+ T+ N L L T +L+
Sbjct: 1243 GDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNE 1302
Query: 254 QNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIK 313
E L+AE +E + EL R + I + + EE KLL ++K
Sbjct: 1303 LEKICEILQAE------------KYELVTELNDSRSECITATRKMA---EEVGKLLNEVK 1347
Query: 314 DDNQEIASMERQLTD 328
N + + +L +
Sbjct: 1348 ILNDDSGLLHGELVE 1362
Score = 38.1 bits (87), Expect = 0.013
Identities = 39/176 (22%), Positives = 76/176 (43%), Gaps = 17/176 (9%)
Query: 114 KLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDY 173
++Q E + S + + L +EL L ++++L T+M+ +
Sbjct: 2724 EIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELK-KTKMDN-LKYV 2781
Query: 174 NMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQ-----EKQATDDIIKNMSFENQV 228
N LK +N+R + ++ + E++ +++E+ Q EKQ T ++ E
Sbjct: 2782 NQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTT 2841
Query: 229 KYLEMKTTNEKLLQELD-------TLQQQLDSQNMKKESLEAEIAH---SQVKQEA 274
+ E+K T E+ +E D +L + KE LE ++AH Q KQ++
Sbjct: 2842 EIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDS 2897
Score = 35.8 bits (81), Expect = 0.064
Identities = 39/190 (20%), Positives = 83/190 (43%), Gaps = 37/190 (19%)
Query: 198 EKQIRSVEEEIEQEKQATDDI---------IKNMSFENQVKYLEM-----KTTNEKL--- 240
+ ++ S+E +E +KQ D+ IK EN +K +M T++++
Sbjct: 829 QNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKL 888
Query: 241 --------------LQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELES 286
L L+ +++L N K E+ +AEI ++K+ LL + L EL+
Sbjct: 889 QEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEI--QELKKSNHLLEDSLKELQL 946
Query: 287 HRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEI----ASMERQLTDTKEKINQFIEEIRQ 342
+ + E K + S + ++ ++++ +N + AS+ ++ + +K F I +
Sbjct: 947 LSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDE 1006
Query: 343 LDMDLEEHQD 352
+ + E D
Sbjct: 1007 REKSISELSD 1016
Score = 35.0 bits (79), Expect = 0.11
Identities = 25/114 (21%), Positives = 55/114 (48%), Gaps = 5/114 (4%)
Query: 238 EKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKS 297
++L +LD L+++ + + +SLEA + + K E + E+ R I E
Sbjct: 21 QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE--- 77
Query: 298 IGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQ 351
S + ++K+ +++ ++ E QL K++I + +E+++ +LE Q
Sbjct: 78 --SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQ 129
Score = 34.7 bits (78), Expect = 0.14
Identities = 31/188 (16%), Positives = 82/188 (43%), Gaps = 11/188 (5%)
Query: 190 IFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQ 249
+ + +A+ +++R+ E+E Q + +K + Q L+++ +L+++ L +
Sbjct: 279 LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNK 338
Query: 250 QLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLY----ELESHRDQMIAEDKSIGSPMEER 305
D E + + Q + L +KL +L R + S+ ++E+
Sbjct: 339 CRD------ELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEK 392
Query: 306 EK-LLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKN 364
EK +++ + +++++ K ++ Q +++ + + L+ D + LE N
Sbjct: 393 EKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENN 452
Query: 365 TGSFKKQV 372
FK+++
Sbjct: 453 LEEFKQKL 460
Score = 30.8 bits (68), Expect = 2.0
Identities = 41/189 (21%), Positives = 75/189 (39%), Gaps = 44/189 (23%)
Query: 93 DKSYYLGLLR-----SKISELTTEVNKLQKGIE-----MYNQENSVYLSYEKRAETLAVE 142
D S+Y LL S +S L V+ Q ++ +EN L+ ++ A
Sbjct: 1492 DSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEEN---LTRKETPSAPAKG 1548
Query: 143 IKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIR 202
++EL+ Y ++KL E + +M K K+I+
Sbjct: 1549 VEELESLCEVYRQSLEKLEEKMESQGIM--------------------------KNKEIQ 1582
Query: 203 SVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLE 262
+E+ + E+Q D + K EN+ + K T+ L E ++ ++ + SLE
Sbjct: 1583 ELEQLLSSERQELDCLRKQYLSENE--QWQQKLTSVTLEMESKLAAEKKQTEQL---SLE 1637
Query: 263 AEIAHSQVK 271
E+A Q++
Sbjct: 1638 LEVARLQLQ 1646
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 58.2 bits (139), Expect = 1e-08
Identities = 73/312 (23%), Positives = 134/312 (42%), Gaps = 59/312 (18%)
Query: 104 KISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTN 163
K+S+L E +L + +E ++ +RAE L E++ LQ + V L T
Sbjct: 605 KLSQLEFEKRQLHRDLEQAKEKG-------ERAEKLERELQRLQEENGRLARKVTSLETA 657
Query: 164 TEMEEVMNDYNM-LKAQNDRETQSLDVIFTERQAKEKQIRSVE---EEIEQEKQATDDII 219
TE E + + L+ +N +SLD + Q Q+ +E ++++ E ++
Sbjct: 658 TEKVEALEHESQGLQLENRTLRKSLDTL----QNVSLQLEGLERDNKQLDAENLELRRLV 713
Query: 220 KNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDS-QNMKKESLEAEIAHSQVKQEAVLLH 278
+ M F + K +M+ N++L +E + L++ +D + + K+S E+++ V E + L
Sbjct: 714 ETMRFTS-TKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQ 772
Query: 279 EKLYELESHRDQMIAEDKSIGSPMEEREKLLKQI-----------------KDDNQEIAS 321
+ L E SH+ Q + + +G ER+ L + + K QE+A
Sbjct: 773 QSL-ESSSHKTQTL--ESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ 829
Query: 322 MERQ---------------------LTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKI 360
+E+ L D+ K++ +E R LD +L +D K
Sbjct: 830 LEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAG-KLKE 888
Query: 361 LEKNTGSFKKQV 372
LEK+ KQV
Sbjct: 889 LEKDNRDLTKQV 900
Score = 49.7 bits (117), Expect = 4e-06
Identities = 54/267 (20%), Positives = 124/267 (46%), Gaps = 46/267 (17%)
Query: 101 LRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL 160
L+SK+ +L + + +K IE +EN V L + K+ + A +++L
Sbjct: 390 LKSKLHDLELDRDTDKKRIEELLEENMV----------LEIAQKQSMNESAHLGWELEQL 439
Query: 161 NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIK 220
+ N ++ + +F + +I +E+E Q Q+T ++
Sbjct: 440 SKNADLSDASRK---------------SFVFELNECASSRILKLEKE-NQSLQSTIQGLR 483
Query: 221 NMSF---ENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLL 277
+ S E+ +K E++ N +L ++++ LQ QL+ + + LE ++ ++++ L
Sbjct: 484 DASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLET-LSEELIREKEQLQ 542
Query: 278 HE----------KLYELESHRDQMIAEDKSIGSPMEEREKLLKQ--IKDDNQEIASMERQ 325
+ ++ +LE +D + ++++ S + ER ++ + +KD +E ++ +
Sbjct: 543 SDMETLKADKARQIKDLEQEKDHL---NRAMWS-LRERSQVSSEARMKDVEKENKALHQT 598
Query: 326 LTDTKEKINQFIEEIRQLDMDLEEHQD 352
+T+ K++Q E RQL DLE+ ++
Sbjct: 599 VTEANGKLSQLEFEKRQLHRDLEQAKE 625
Score = 48.9 bits (115), Expect = 7e-06
Identities = 68/286 (23%), Positives = 124/286 (43%), Gaps = 48/286 (16%)
Query: 103 SKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNT 162
S+I +L E LQ I+ + V E ++ EL+ + + ++KL T
Sbjct: 463 SRILKLEKENQSLQSTIQGLRDASLVL-------EESGLKCGELEKENHQLSKKIEKLQT 515
Query: 163 NTEMEEVMN-DYNMLKAQNDRETQSLDV-IFTERQAKEKQIRSVEEE-----------IE 209
E E+ N D L + RE + L + T + K +QI+ +E+E E
Sbjct: 516 QLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRE 575
Query: 210 QEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQ-ELDTLQQQLDSQNMKK-----ESLEA 263
+ + +++ +K++ EN+ + + N KL Q E + Q D + K+ E LE
Sbjct: 576 RSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLER 635
Query: 264 EIAHSQVKQEAVLLHEKLYELESHRDQMIA-EDKSIGSPMEER----------------- 305
E+ ++++E L K+ LE+ +++ A E +S G +E R
Sbjct: 636 EL--QRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLE 693
Query: 306 --EKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEE 349
E+ KQ+ +N E+ + + T K+ Q E +QL+ + EE
Sbjct: 694 GLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEE 739
Score = 47.8 bits (112), Expect = 2e-05
Identities = 56/293 (19%), Positives = 124/293 (42%), Gaps = 40/293 (13%)
Query: 59 GVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKG 118
G S +++++++ V+ + L Q+ + S+ L S++ EL E L++
Sbjct: 751 GKKSERLELSYQSVSAENLR--------LQQSLESSSHKTQTLESELGELEAERQALRRD 802
Query: 119 IEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKA 178
+E N+ EK + L E+ +L+ DK E + + + A
Sbjct: 803 LEALRLANAQLEGAEKDRKALEQEVAQLEK---------DKKLLEKEAKRLWQQVELKDA 853
Query: 179 QNDRETQSLDVIFTERQAKEKQI---RSVEEEIEQEKQATDDIIKNMSFENQV------K 229
D T L + E +A +K++ R ++++ ++ D+ K ++ +
Sbjct: 854 VLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLRED 913
Query: 230 YLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRD 289
+ K +++L ELD L Q+L+ + +E L QE + Y++ R+
Sbjct: 914 LVLEKLKSQQLSSELDKLSQELEKVGLNRELL---------LQEDDSGSDTKYKILEGRN 964
Query: 290 QMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQ 342
+ ++ + + +E+ + ++ +E AS+ RQL + + + E +RQ
Sbjct: 965 -----ESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQ 1012
Score = 43.1 bits (100), Expect = 4e-04
Identities = 59/254 (23%), Positives = 114/254 (44%), Gaps = 28/254 (11%)
Query: 107 ELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEM 166
+L E +L++ +E ++ E+ + L E +EL+ + L+ L +E
Sbjct: 701 QLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVD----LLKALGKKSER 756
Query: 167 EEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFEN 226
E+ Y + A+N R QSL+ + Q E ++ E+E E+QA ++ + N
Sbjct: 757 LEL--SYQSVSAENLRLQQSLESSSHKTQTLESELG----ELEAERQALRRDLEALRLAN 810
Query: 227 QVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELES 286
LE + K L++ + Q + D + ++KE A+ QV+ + +L + +L +
Sbjct: 811 A--QLEGAEKDRKALEQ-EVAQLEKDKKLLEKE---AKRLWQQVELKDAVLDDSTAKLSA 864
Query: 287 HRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASM----ERQLTDTKE-------KINQ 335
+ A DK + + KL K+++ DN+++ R LT +E K Q
Sbjct: 865 VEKESRALDKELARCRDAAGKL-KELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQ 923
Query: 336 FIEEIRQLDMDLEE 349
E+ +L +LE+
Sbjct: 924 LSSELDKLSQELEK 937
Score = 31.2 bits (69), Expect = 1.6
Identities = 33/152 (21%), Positives = 65/152 (42%), Gaps = 16/152 (10%)
Query: 130 LSYEKRAETLAV-EIKELQGQLADYNMLVDKLN------------TNTEMEEVMNDYNML 176
L E+R LA+ E + L+G+L N L +L T + + N
Sbjct: 1237 LQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRW 1296
Query: 177 KAQNDR---ETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEM 233
+A+ D + Q++D+ T+ + + ++ +E+E I+ +S +NQ+ +
Sbjct: 1297 QARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQN 1356
Query: 234 KTTNEKLLQELDTLQQQLDSQNMKKESLEAEI 265
E+ +E +L++ KE LE +I
Sbjct: 1357 MENKEQYHEEQKQYIDKLNALRRHKEKLEEKI 1388
Score = 29.3 bits (64), Expect = 6.0
Identities = 36/168 (21%), Positives = 75/168 (44%), Gaps = 36/168 (21%)
Query: 210 QEKQATDDIIKNMSFENQ---VKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIA 266
+ K+ + IK + E Q V +++ T N++ + +L Q L+ ++ E LEA ++
Sbjct: 135 ERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDL----QWLELPDVAPEELEA-LS 189
Query: 267 HSQVKQEAVLLHEK------LYELESHRDQMIAEDK----------SIGSPM-----EER 305
S V L+ ++ + +L RD + A+ S SP E++
Sbjct: 190 RSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDK 249
Query: 306 EKLLKQIKDDN-------QEIASMERQLTDTKEKINQFIEEIRQLDMD 346
+ L ++ D QE+ QL DT+ +++Q + E++++ +
Sbjct: 250 QHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQE 297
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 57.8 bits (138), Expect = 2e-08
Identities = 65/297 (21%), Positives = 133/297 (44%), Gaps = 28/297 (9%)
Query: 88 QRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQ 147
Q + + L L++ EL + +LQ E ++E+++ L ++ L ++ +
Sbjct: 730 QEALQSREQSLDALQTHYDELQARLGELQG--EAASREDTICLLQNEKI-ILEAALQAAK 786
Query: 148 GQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEE 207
+ + +L TE E L+ + ++ ++ + E A +KQ++ ++E+
Sbjct: 787 SGKEELDRGARRLEEGTE--ETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQ 844
Query: 208 IEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAH 267
Q+K + ++ + ++Q+ E+K T ++L EL L+Q+L + +K + EAE++
Sbjct: 845 FLQQKVMVEAYRRDATSKDQL-ISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSR 903
Query: 268 -----SQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEE-------REKLLKQIKDD 315
+QV+Q L L + RD+M +S+ E+ E L KQI++
Sbjct: 904 LHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEEL 963
Query: 316 NQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQDPTNYGWKILEKNTGSFKKQV 372
QE + +T+ K+K +R+L DL Q K E G +++
Sbjct: 964 QQE---ARKAITEQKQK-------MRRLGSDLTSAQKEMKTKHKAYENAVGILSRRL 1010
Score = 38.5 bits (88), Expect = 0.010
Identities = 56/329 (17%), Positives = 133/329 (40%), Gaps = 48/329 (14%)
Query: 61 LSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSY--YLGLLRSKISELTTEVNKLQKG 118
L +Q++ +H +Q + T L+++ +L +K + L + N LQ
Sbjct: 449 LQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVA 508
Query: 119 IEMYNQ--------ENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVM 170
E Y + + S+ LS + L ++ LQ QL + ++ ++++
Sbjct: 509 EEQYQRLMAKVEDMQRSM-LSKDNTVHDLRQQMTALQSQLQQVQL--ERTTLTSKLKASQ 565
Query: 171 NDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEE--EIEQEKQATDDIIKNMSFENQV 228
+ + L++ Q L + A+E ++R E I+ + +++++ EN
Sbjct: 566 AEISSLQSVRQWYQQQLAL------AQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVS 619
Query: 229 KYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHE----KLYEL 284
++ T + ++E + QL Q ++ + L+ E A Q+++ ++ E +L E
Sbjct: 620 LSQQLTETQHRSMKEKGRIAAQL--QGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEF 677
Query: 285 ESHRDQM---------------------IAEDKSIGSPMEEREKLLKQIKDDNQEIASME 323
E R+++ + D+ + + +E L+KQ+ + + S E
Sbjct: 678 EGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSRE 737
Query: 324 RQLTDTKEKINQFIEEIRQLDMDLEEHQD 352
+ L + ++ + +L + +D
Sbjct: 738 QSLDALQTHYDELQARLGELQGEAASRED 766
Score = 38.5 bits (88), Expect = 0.010
Identities = 52/259 (20%), Positives = 109/259 (42%), Gaps = 27/259 (10%)
Query: 101 LRSKISELTTEVNKLQKGIEMYN-QENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDK 159
LR S L T + K + + N Q +V E+ + ++ LQ L V+
Sbjct: 1131 LREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNS 1190
Query: 160 LNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDII 219
L +V +N + + L + E QAKE ++ ++ E A D I
Sbjct: 1191 LKEQVAAAKVEAGHN--RRHFKAASLELSEVKKELQAKEHLVQKLQAE------ADDLQI 1242
Query: 220 KNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHE 279
+ ++ + + + +L LQ+QLD Q K+ + + +++ + +
Sbjct: 1243 REGKHSQEIAQFQAELAEARA--QLQLLQKQLDEQLSKQ-----PVGNQEMENLKWEVDQ 1295
Query: 280 KLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDD---NQEIASM--------ERQLTD 328
K E++S + Q+ ++ +E ++LL+ +K + QE SM + ++++
Sbjct: 1296 KEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSE 1355
Query: 329 TKEKINQFIEEIRQLDMDL 347
K + +++ +QL +DL
Sbjct: 1356 LKNNMKTLLQQNQQLKLDL 1374
Score = 38.1 bits (87), Expect = 0.013
Identities = 62/312 (19%), Positives = 134/312 (42%), Gaps = 49/312 (15%)
Query: 63 SQIKVAHRPVTQ--QGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELT--TEVNK-LQK 117
+++ HR V Q Q + ++ + Q++ + +L L+ ++ TE N+ L+K
Sbjct: 899 AELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKK 958
Query: 118 GIEMYNQENSVYLSYEKR-----AETLAVEIKELQGQLADYNMLVDKLNTNTE-----ME 167
IE QE ++ +K+ L KE++ + Y V L+ + E
Sbjct: 959 QIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKE 1018
Query: 168 EVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQ 227
+ L+AQ SL A ++I+++E E++ + + K +
Sbjct: 1019 AADAELGQLRAQGGSSDSSL--------ALHERIQALEAELQAVSHSKTLLEKELQEVIA 1070
Query: 228 VKYLEMKTTNEKLLQELDTLQQ---------QLDSQNMKKESLEAE----------IAHS 268
+ E++ + EK+L+ D LQ+ +L+ N KK +LE E +++
Sbjct: 1071 LTSQELEESREKVLELEDELQESRGFRKKIKRLEESN-KKLALELEHEKGKLTGLGQSNA 1129
Query: 269 QVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTD 328
+++ +L L + E+ Q+ + +++ EE ++ +K + + +++ L
Sbjct: 1130 ALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHL------VQALQASLEK 1183
Query: 329 TKEKINQFIEEI 340
KEK+N E++
Sbjct: 1184 EKEKVNSLKEQV 1195
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.127 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,998,589
Number of Sequences: 37866
Number of extensions: 617985
Number of successful extensions: 7873
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 218
Number of HSP's successfully gapped in prelim test: 939
Number of HSP's that attempted gapping in prelim test: 3987
Number of HSP's gapped (non-prelim): 3294
length of query: 372
length of database: 18,247,518
effective HSP length: 104
effective length of query: 268
effective length of database: 14,309,454
effective search space: 3834933672
effective search space used: 3834933672
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.