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Search of human proteins with 150417967
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150417967 voltage-gated sodium channel type V alpha isoform
c [Homo sapiens]
(2016 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150417967 voltage-gated sodium channel type V alpha isoform c... 4048 0.0
gi|37622907 voltage-gated sodium channel type V alpha isoform a ... 4034 0.0
gi|30089970 voltage-gated sodium channel type V alpha isoform b ... 4028 0.0
gi|150417969 voltage-gated sodium channel type V alpha isoform d... 3999 0.0
gi|237512980 voltage-gated sodium channel type V alpha isoform e... 3960 0.0
gi|237512982 voltage-gated sodium channel type V alpha isoform f... 3897 0.0
gi|126362949 sodium channel, voltage-gated, type III, alpha isof... 2425 0.0
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 2414 0.0
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor... 2414 0.0
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor... 2414 0.0
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ... 2386 0.0
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ... 2378 0.0
gi|126362955 sodium channel, voltage-gated, type III, alpha isof... 2377 0.0
gi|126362947 sodium channel, voltage-gated, type III, alpha isof... 2377 0.0
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 2350 0.0
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo... 2333 0.0
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi... 1731 0.0
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo... 1375 0.0
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated... 1323 0.0
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom... 1121 0.0
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 455 e-127
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 455 e-127
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 454 e-127
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 450 e-126
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 449 e-125
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i... 449 e-125
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i... 449 e-125
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 449 e-125
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 449 e-125
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 449 e-125
>gi|150417967 voltage-gated sodium channel type V alpha isoform c
[Homo sapiens]
Length = 2016
Score = 4048 bits (10497), Expect = 0.0
Identities = 2016/2016 (100%), Positives = 2016/2016 (100%)
Query: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
Query: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
Query: 661 RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661 RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
Query: 721 LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721 LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
Query: 781 WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781 WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
Query: 841 NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841 NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
Query: 901 ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901 ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
Query: 961 LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961 LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
Query: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS
Sbjct: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
Query: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
Query: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
Query: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
Query: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
Query: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
Sbjct: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
Query: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
Query: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
Query: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
Sbjct: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
Query: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
Query: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
Query: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
Query: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
Query: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
Query: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
Query: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
sapiens]
Length = 2016
Score = 4034 bits (10463), Expect = 0.0
Identities = 2009/2016 (99%), Positives = 2012/2016 (99%)
Query: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
Query: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
Query: 661 RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661 RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
Query: 721 LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721 LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
Query: 781 WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781 WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
Query: 841 NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841 NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
Query: 901 ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901 ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
Query: 961 LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961 LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
Query: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS
Sbjct: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
Query: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
Query: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
Query: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
Query: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
Query: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
Sbjct: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
Query: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
Query: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
Query: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
Sbjct: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
Query: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
Query: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
Query: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
Query: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
Query: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
Query: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
Query: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
sapiens]
Length = 2015
Score = 4028 bits (10446), Expect = 0.0
Identities = 2008/2016 (99%), Positives = 2011/2016 (99%), Gaps = 1/2016 (0%)
Query: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
Query: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
Query: 661 RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661 RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
Query: 721 LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721 LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
Query: 781 WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781 WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
Query: 841 NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841 NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
Query: 901 ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901 ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
Query: 961 LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961 LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK QESQ
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK-QESQ 1079
Query: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS
Sbjct: 1080 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1139
Query: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1140 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1199
Query: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1200 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1259
Query: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1260 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1319
Query: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1320 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1379
Query: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
Sbjct: 1380 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1439
Query: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1440 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1499
Query: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1500 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1559
Query: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
Sbjct: 1560 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1619
Query: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1620 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1679
Query: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1680 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1739
Query: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1740 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1799
Query: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1800 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1859
Query: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1860 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1919
Query: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1920 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1979
Query: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1980 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2015
>gi|150417969 voltage-gated sodium channel type V alpha isoform d
[Homo sapiens]
Length = 1998
Score = 3999 bits (10371), Expect = 0.0
Identities = 1998/2016 (99%), Positives = 1998/2016 (99%), Gaps = 18/2016 (0%)
Query: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
Query: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
Query: 661 RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661 RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
Query: 721 LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721 LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
Query: 781 WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781 WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
Query: 841 NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841 NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
Query: 901 ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901 ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
Query: 961 LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961 LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
Query: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS
Sbjct: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
Query: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
Query: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
Query: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
Query: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
Query: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV YEEQPQW
Sbjct: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV------------------YEEQPQW 1422
Query: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1423 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1482
Query: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1483 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1542
Query: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
Sbjct: 1543 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1602
Query: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1603 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1662
Query: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1663 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1722
Query: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1723 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1782
Query: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1783 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1842
Query: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1843 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1902
Query: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1903 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1962
Query: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1963 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1998
>gi|237512980 voltage-gated sodium channel type V alpha isoform e
[Homo sapiens]
Length = 1983
Score = 3960 bits (10269), Expect = 0.0
Identities = 1983/2016 (98%), Positives = 1983/2016 (98%), Gaps = 33/2016 (1%)
Query: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
Query: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
Query: 661 RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661 RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
Query: 721 LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721 LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
Query: 781 WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781 WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
Query: 841 NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841 NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
Query: 901 ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901 ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
Query: 961 LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961 LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK QESQ
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK-QESQ 1079
Query: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS
Sbjct: 1080 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1139
Query: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1140 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1199
Query: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1200 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1259
Query: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1260 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1319
Query: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1320 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1379
Query: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
Sbjct: 1380 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1439
Query: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1440 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1499
Query: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1500 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1559
Query: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
AKINLLFVAIFT GTVLSDIIQKYFFSPT
Sbjct: 1560 AKINLLFVAIFT--------------------------------GTVLSDIIQKYFFSPT 1587
Query: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1588 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1647
Query: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1648 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1707
Query: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1708 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1767
Query: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1768 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1827
Query: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1828 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1887
Query: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1888 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1947
Query: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1948 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1983
>gi|237512982 voltage-gated sodium channel type V alpha isoform f
[Homo sapiens]
Length = 1962
Score = 3897 bits (10105), Expect = 0.0
Identities = 1959/2016 (97%), Positives = 1959/2016 (97%), Gaps = 54/2016 (2%)
Query: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
Query: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
Query: 661 RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661 RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
Query: 721 LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721 LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
Query: 781 WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781 WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
Query: 841 NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841 NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
Query: 901 ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901 ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
Query: 961 LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961 LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ---- 1076
Query: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
P DS C E GS
Sbjct: 1077 -------TPEDS-----------------------------------CSE--------GS 1086
Query: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1087 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1146
Query: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1147 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1206
Query: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1207 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1266
Query: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1267 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1326
Query: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
Sbjct: 1327 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1386
Query: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1387 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1446
Query: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1447 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1506
Query: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
Sbjct: 1507 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1566
Query: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1567 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
Query: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1627 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1686
Query: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1687 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1746
Query: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1747 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1806
Query: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1807 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1866
Query: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1867 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1926
Query: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1927 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1962
>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
[Homo sapiens]
Length = 2000
Score = 2425 bits (6284), Expect = 0.0
Identities = 1291/2065 (62%), Positives = 1524/2065 (73%), Gaps = 168/2065 (8%)
Query: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
L+P G SFR FTRESLAAIEKR AE++A+ Q++ +E P+P DL+A K L
Sbjct: 6 LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
Query: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
P +YG+ P E++ EPLEDLDP+Y +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 62 PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
+KILVHSLF+MLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KILARGFCL
Sbjct: 122 IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
Query: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 182 DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++ N T+
Sbjct: 242 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
Query: 288 NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347
NGT +V W+ Y+ D ++ + +G D LLCGN SDAG CPEGY C+KAG N
Sbjct: 302 NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
Query: 348 PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407
P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 359 PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
Query: 408 ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453
ILAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ E I G+
Sbjct: 419 ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
Query: 454 DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509
+ SS E S L+ ++ E R++R+KR G + D PKS+SED + + L
Sbjct: 479 GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
Query: 510 SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548
G TS K R+S+ SIF+FR R D+GSE DFADDE+
Sbjct: 539 FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
Query: 549 STAGESESHHTSLLVPWPL--RRTSAQGQPSPGTS-APGHALHGKKNSTVDCNGVVSLLG 605
ST +SES SL VP RR S Q S + PG +GK +STVDCNGVVSL+G
Sbjct: 599 STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658
Query: 606 AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665
G TSP L PP+ TT E + L+S ++ E+ RQRA+S
Sbjct: 659 -GPSALTSPTGQL--------PPEGTTTETEVR-KRRLSSYQISMEMLEDSSGRQRAVSI 708
Query: 666 VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725
S+LT+ +EELEESR KCPPCW R A +LIW+CC W+ +K V L+VMDPF DL IT+
Sbjct: 709 ASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITI 768
Query: 726 CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785
CIVLNTLFMA+EHY MT +F +L VGNLVFTGIFTAEM KIIA+DPYYYFQ+GWNIFD
Sbjct: 769 CIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFD 828
Query: 786 SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
IIV LSLMELGLS + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLV
Sbjct: 829 GIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 888
Query: 846 LAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETM 903
LAIIVFIFAVVGMQLFGK+Y E + +D LPRWHM DFFH+FLI+FR+LCGEWIETM
Sbjct: 889 LAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 948
Query: 904 WDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLAL 963
WDCMEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 949 WDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAV 1008
Query: 964 ARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023
R+Q+G+ +VK + C R K + ++ SC++ ++
Sbjct: 1009 GRMQKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKEL 1061
Query: 1024 KETRFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEEN 1065
R G G GT E V VPIAV ESD ++ +E +
Sbjct: 1062 NYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFS 1121
Query: 1066 SLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQA 1125
S EES ++ ++AT+SSE
Sbjct: 1122 SESELEESKEK---------------------LNATSSSE-------------------- 1140
Query: 1126 PGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQ 1185
GST D+ E + + +D+K PE CFTEGC+++ P C V T +
Sbjct: 1141 -------------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEE 1186
Query: 1186 APGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKM 1245
GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+
Sbjct: 1187 GKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKV 1246
Query: 1246 FTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTL 1305
FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTL
Sbjct: 1247 FTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTL 1306
Query: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365
RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF C+N
Sbjct: 1307 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVN 1366
Query: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
T G++ + + VNN S C++L W VKVNFDNVGAGYLALLQVATFKGWMDIM
Sbjct: 1367 MTTGNM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIM 1423
Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
YAAVDSR + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDI
Sbjct: 1424 YAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDI 1483
Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTM 1545
FMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTM
Sbjct: 1484 FMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTM 1543
Query: 1546 MVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVG 1605
MVETDDQ +L++INL+F+ +FTGE ++KL +LRHYYFT WNIFDFVVVILSIVG
Sbjct: 1544 MVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVG 1603
Query: 1606 TVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLF 1665
L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLF
Sbjct: 1604 MFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLF 1663
Query: 1666 LVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGP 1725
LVMFIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ P
Sbjct: 1664 LVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1723
Query: 1726 PYCDP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1784
P CDP T+ + +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES E
Sbjct: 1724 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAE 1783
Query: 1785 PLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVS 1844
PLSEDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL PL IAKPN++ LI MDLPMVS
Sbjct: 1784 PLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVS 1843
Query: 1845 GDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVS 1904
GDRIHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVS
Sbjct: 1844 GDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVS 1903
Query: 1905 AMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPS 1964
A +IQR FR +LL++ LK+ S + ++A G D P ++ +I ++ N + P
Sbjct: 1904 AAIIQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEK 1957
Query: 1965 SSSISSTSFPPSYDSVTRATSDNLQ 1989
+ SST+ PPSYDSVT+ + +
Sbjct: 1958 TDGSSSTTSPPSYDSVTKPDKEKFE 1982
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 2414 bits (6256), Expect = 0.0
Identities = 1291/2081 (62%), Positives = 1528/2081 (73%), Gaps = 176/2081 (8%)
Query: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
L+P G SFR FTRESLAAIE+R+AE++A+ ++ R+ +E P+P DL+A K L
Sbjct: 6 LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
Query: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
P +YG+ P E++ PLEDLDP+Y +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 63 PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
+KILVHSLFNMLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KILARGFCL
Sbjct: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
Query: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
FTFLRDPWNWLDF+VI AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 183 DFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++ N T+ N S+
Sbjct: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
Query: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
+ +G + + D Y+ D ++ G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
Query: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
Query: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
LAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ E G+
Sbjct: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
Query: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
S SS S L+ + E RR K++++ SG EE DR+ KS+SED R
Sbjct: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
Query: 508 ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
H SL R+SR S+F+FR R D+GSE DFADDE+S
Sbjct: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
Query: 550 TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
T +++S SL VP RR S Q S + P ++GK +S VDCNGVVSL+G
Sbjct: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
Query: 607 GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
G TS G L P TTT +E + +S +D E+P +RQRA+S
Sbjct: 659 GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708
Query: 667 SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
S+LT+ +EELEESR KCPPCW + A LIW+CC W+ +K V LVVMDPF DL IT+C
Sbjct: 709 SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
Query: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
IVLNTLFMA+EHY MT +F +L VGNLVFTGIFTAEM KIIA+DPYYYFQ+GWNIFD
Sbjct: 769 IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
Query: 787 IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
IV LSLMELGL+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 829 FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
Query: 847 AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
AIIVFIFAVVGMQLFGK+Y E + S+ LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 889 AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
Query: 905 DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 949 DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
Query: 965 RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
R+Q+G+ FVKR +F + + +K AL + SCI+ T
Sbjct: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059
Query: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
++ + G G G+ +P V VPIAV ESD ++
Sbjct: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119
Query: 1062 DEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKA 1121
+E +S EES ++ ++AT+SSE
Sbjct: 1120 EEFSSESDMEESKEK---------------------LNATSSSEGST------------V 1146
Query: 1122 EPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1181
+ AP GE PE E +PE CFTE CVR+ CC +
Sbjct: 1147 DIGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQI 1184
Query: 1182 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1241
+ GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEY
Sbjct: 1185 SIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1244
Query: 1242 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1301
ADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1245 ADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1304
Query: 1302 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1361
LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF
Sbjct: 1305 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1364
Query: 1362 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKG 1420
CIN T G++ + ++VNN S+C++L + + W VKVNFDNVG GYL+LLQVATFKG
Sbjct: 1365 HCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKG 1423
Query: 1421 WMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1480
WMDIMYAAVDSR E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK
Sbjct: 1424 WMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1483
Query: 1481 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1540
GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICL
Sbjct: 1484 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICL 1543
Query: 1541 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1600
NMVTMMVETDDQS E NIL INL+F+ +FTGEC++KL +LR+YYFT WNIFDFVVVI
Sbjct: 1544 NMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVI 1603
Query: 1601 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1660
LSIVG L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1604 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663
Query: 1661 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1720
GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1723
Query: 1721 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
LN+GPP CDP + S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1724 LNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1783
Query: 1780 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1839
EES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL PL IAKPN++ LI MD
Sbjct: 1784 EESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMD 1843
Query: 1840 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1899
LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1844 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRK 1903
Query: 1900 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1959
EEVSA++IQRA+RR+LL++ +K S ++++ G + P +E + ++EN +
Sbjct: 1904 QEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST-- 1959
Query: 1960 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 2000
P + ST+ PPSYDSVT+ + + D S ED
Sbjct: 1960 --PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 2414 bits (6255), Expect = 0.0
Identities = 1291/2081 (62%), Positives = 1528/2081 (73%), Gaps = 176/2081 (8%)
Query: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
L+P G SFR FTRESLAAIE+R+AE++A+ ++ R+ +E P+P DL+A K L
Sbjct: 6 LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
Query: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
P +YG+ P E++ PLEDLDP+Y +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 63 PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
+KILVHSLFNMLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KILARGFCL
Sbjct: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
Query: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
FTFLRDPWNWLDF+VI AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 183 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++ N T+ N S+
Sbjct: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
Query: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
+ +G + + D Y+ D ++ G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
Query: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
Query: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
LAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ E G+
Sbjct: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
Query: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
S SS S L+ + E RR K++++ SG EE DR+ KS+SED R
Sbjct: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
Query: 508 ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
H SL R+SR S+F+FR R D+GSE DFADDE+S
Sbjct: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
Query: 550 TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
T +++S SL VP RR S Q S + P ++GK +S VDCNGVVSL+G
Sbjct: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
Query: 607 GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
G TS G L P TTT +E + +S +D E+P +RQRA+S
Sbjct: 659 GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708
Query: 667 SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
S+LT+ +EELEESR KCPPCW + A LIW+CC W+ +K V LVVMDPF DL IT+C
Sbjct: 709 SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
Query: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
IVLNTLFMA+EHY MT +F +L VGNLVFTGIFTAEM KIIA+DPYYYFQ+GWNIFD
Sbjct: 769 IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
Query: 787 IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
IV LSLMELGL+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 829 FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
Query: 847 AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
AIIVFIFAVVGMQLFGK+Y E + S+ LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 889 AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
Query: 905 DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 949 DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
Query: 965 RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
R+Q+G+ FVKR +F + + +K AL + SCI+ T
Sbjct: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059
Query: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
++ + G G G+ +P V VPIAV ESD ++
Sbjct: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119
Query: 1062 DEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKA 1121
+E +S EES ++ ++AT+SSE
Sbjct: 1120 EEFSSESDMEESKEK---------------------LNATSSSEGST------------V 1146
Query: 1122 EPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1181
+ AP GE PE E +PE CFTE CVR+ CC +
Sbjct: 1147 DIGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQI 1184
Query: 1182 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1241
+ GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEY
Sbjct: 1185 SIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1244
Query: 1242 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1301
ADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1245 ADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1304
Query: 1302 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1361
LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF
Sbjct: 1305 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1364
Query: 1362 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKG 1420
CIN T G++ + ++VNN S+C++L + + W VKVNFDNVG GYL+LLQVATFKG
Sbjct: 1365 HCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKG 1423
Query: 1421 WMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1480
WMDIMYAAVDSR E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK
Sbjct: 1424 WMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1483
Query: 1481 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1540
GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICL
Sbjct: 1484 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICL 1543
Query: 1541 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1600
NMVTMMVETDDQS E NIL INL+F+ +FTGEC++KL +LR+YYFT WNIFDFVVVI
Sbjct: 1544 NMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVI 1603
Query: 1601 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1660
LSIVG L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1604 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663
Query: 1661 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1720
GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1723
Query: 1721 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
LN+GPP CDP + S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1724 LNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1783
Query: 1780 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1839
EES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL PL IAKPN++ LI MD
Sbjct: 1784 EESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMD 1843
Query: 1840 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1899
LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1844 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRK 1903
Query: 1900 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1959
EEVSA++IQRA+RR+LL++ +K S ++++ G + P +E + ++EN +
Sbjct: 1904 QEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST-- 1959
Query: 1960 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 2000
P + ST+ PPSYDSVT+ + + D S ED
Sbjct: 1960 --PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 2414 bits (6255), Expect = 0.0
Identities = 1291/2081 (62%), Positives = 1528/2081 (73%), Gaps = 176/2081 (8%)
Query: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
L+P G SFR FTRESLAAIE+R+AE++A+ ++ R+ +E P+P DL+A K L
Sbjct: 6 LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
Query: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
P +YG+ P E++ PLEDLDP+Y +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 63 PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
+KILVHSLFNMLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KILARGFCL
Sbjct: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
Query: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
FTFLRDPWNWLDF+VI AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 183 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++ N T+ N S+
Sbjct: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
Query: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
+ +G + + D Y+ D ++ G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
Query: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
Query: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
LAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ E G+
Sbjct: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
Query: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
S SS S L+ + E RR K++++ SG EE DR+ KS+SED R
Sbjct: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
Query: 508 ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
H SL R+SR S+F+FR R D+GSE DFADDE+S
Sbjct: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
Query: 550 TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
T +++S SL VP RR S Q S + P ++GK +S VDCNGVVSL+G
Sbjct: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
Query: 607 GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
G TS G L P TTT +E + +S +D E+P +RQRA+S
Sbjct: 659 GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708
Query: 667 SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
S+LT+ +EELEESR KCPPCW + A LIW+CC W+ +K V LVVMDPF DL IT+C
Sbjct: 709 SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
Query: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
IVLNTLFMA+EHY MT +F +L VGNLVFTGIFTAEM KIIA+DPYYYFQ+GWNIFD
Sbjct: 769 IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
Query: 787 IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
IV LSLMELGL+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 829 FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
Query: 847 AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
AIIVFIFAVVGMQLFGK+Y E + S+ LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 889 AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
Query: 905 DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 949 DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
Query: 965 RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
R+Q+G+ FVKR +F + + +K AL + SCI+ T
Sbjct: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059
Query: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
++ + G G G+ +P V VPIAV ESD ++
Sbjct: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119
Query: 1062 DEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKA 1121
+E +S EES ++ ++AT+SSE
Sbjct: 1120 EEFSSESDMEESKEK---------------------LNATSSSEGST------------V 1146
Query: 1122 EPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1181
+ AP GE PE E +PE CFTE CVR+ CC +
Sbjct: 1147 DIGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQI 1184
Query: 1182 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1241
+ GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEY
Sbjct: 1185 SIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1244
Query: 1242 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1301
ADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1245 ADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1304
Query: 1302 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1361
LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF
Sbjct: 1305 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1364
Query: 1362 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKG 1420
CIN T G++ + ++VNN S+C++L + + W VKVNFDNVG GYL+LLQVATFKG
Sbjct: 1365 HCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKG 1423
Query: 1421 WMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1480
WMDIMYAAVDSR E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK
Sbjct: 1424 WMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1483
Query: 1481 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1540
GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICL
Sbjct: 1484 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICL 1543
Query: 1541 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1600
NMVTMMVETDDQS E NIL INL+F+ +FTGEC++KL +LR+YYFT WNIFDFVVVI
Sbjct: 1544 NMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVI 1603
Query: 1601 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1660
LSIVG L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1604 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663
Query: 1661 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1720
GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1723
Query: 1721 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
LN+GPP CDP + S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1724 LNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1783
Query: 1780 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1839
EES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL PL IAKPN++ LI MD
Sbjct: 1784 EESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMD 1843
Query: 1840 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1899
LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1844 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRK 1903
Query: 1900 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1959
EEVSA++IQRA+RR+LL++ +K S ++++ G + P +E + ++EN +
Sbjct: 1904 QEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST-- 1959
Query: 1960 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 2000
P + ST+ PPSYDSVT+ + + D S ED
Sbjct: 1960 --PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
sapiens]
Length = 1998
Score = 2386 bits (6183), Expect = 0.0
Identities = 1277/2068 (61%), Positives = 1507/2068 (72%), Gaps = 159/2068 (7%)
Query: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
L+P G SF FTRESLAAIE+R+AE++A+ ++ +E P+P DL+A K L
Sbjct: 6 LVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD----DDENGPKPNSDLEAGKNL 61
Query: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
P +YG+ P E++ EPLEDLDP+Y +KTFIVLNKGK IFRFSAT+ALY+L+PF+P+R+ A
Sbjct: 62 PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIA 121
Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
+KILVHSLF+MLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KI+ARGFCL
Sbjct: 122 IKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLE 181
Query: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
FTFLRDPWNWLDF+VI AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 182 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---------------RNFTA-LN 288
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC+ +N T N
Sbjct: 242 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYN 301
Query: 289 GTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
GT + W+S Y+ D + G D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 302 GTLINETVFEFDWKS---YIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358
Query: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 359 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418
Query: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSR---------- 458
LAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ EA T S
Sbjct: 419 LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478
Query: 459 ---SSLEMSPLAPVNSHERRSKRRKRMS---SGTEECGEDRLPKSDSEDGPRAMN----- 507
SS E S L+ ++ ERR++R+KR SG EE ED KS+SED R
Sbjct: 479 LSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSI 538
Query: 508 --------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENSTA 551
H SL R+SR S+F+FR R D+GSE DFADDE+ST
Sbjct: 539 EGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTF 598
Query: 552 GESESHHTSLLVP--WPLRRTSAQGQPSPGTSAPG-HALHGKKNSTVDCNGVVSLLGAGD 608
++ES SL VP RR S Q S + +GK +STVDCNGVVSL+G G
Sbjct: 599 EDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG-GP 657
Query: 609 PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
TSP LL P TTT +E + +S +D E+P RQRA+S S+
Sbjct: 658 SVPTSPVGQLL-------PEGTTTETEMR--KRRSSSFHVSMDFLEDPSQRQRAMSIASI 708
Query: 669 LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728
LT+ +EELEESR KCPPCW + + +LIW+C P W+ +K V LVVMDPF DL IT+CIV
Sbjct: 709 LTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIV 768
Query: 729 LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788
LNTLFMA+EHY MT F +L VGNLVFTGIFTAEM KIIA+DPYYYFQ+GWNIFD I
Sbjct: 769 LNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 828
Query: 789 VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848
V LSL+ELGL+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 829 VTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 888
Query: 849 IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906
IVFIFAVVGMQLFGK+Y + + + LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 889 IVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 948
Query: 907 MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966
MEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+A+ R+
Sbjct: 949 MEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRM 1008
Query: 967 QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026
+G+ +VKR ++F + + +K L L S T ++
Sbjct: 1009 HKGVAYVKRKIYEF---IQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYL 1065
Query: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068
+ G G GT E V VPIAV ESD ++ L
Sbjct: 1066 KDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFEN--------LN 1117
Query: 1069 TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGC 1128
TE+ SS+ S+ E S + +
Sbjct: 1118 TEDFSSE----------------------------SDLEESKEKLN-------------- 1135
Query: 1129 GETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPG 1188
S SEGST D+ E EQ ++ +PE CFTEGCV+R CC ++ + G
Sbjct: 1136 ---ESSSSSEGSTVDIGAPVE--EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRG 1190
Query: 1189 KVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTY 1248
K WW LR+TC+ IVEH+WFETFI+FMILLSSGALAFEDIY+++RKTIK +LEYADK+FTY
Sbjct: 1191 KQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTY 1250
Query: 1249 VFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRAL 1308
+F+LEMLLKWVAYG++ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRAL
Sbjct: 1251 IFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1310
Query: 1309 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTE 1368
RPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF CIN T
Sbjct: 1311 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTT 1370
Query: 1369 GDLPLNYTIVNNKSQCESLNLTGE-LYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYA 1427
GD + VNN + C L E W VKVNFDNVG GYL+LLQVATFKGWMDIMYA
Sbjct: 1371 GD-RFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
Query: 1428 AVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM 1487
AVDSR E QP++E +LYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFM
Sbjct: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
Query: 1488 TEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMV 1547
TEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMV
Sbjct: 1490 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMV 1549
Query: 1548 ETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTV 1607
ETDDQS IL++INL+F+ +FTGEC++KL +LRHYYFT WNIFDFVVVILSIVG
Sbjct: 1550 ETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMF 1609
Query: 1608 LSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLV 1667
L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLV
Sbjct: 1610 LAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1669
Query: 1668 MFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPY 1727
MFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP
Sbjct: 1670 MFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPD 1729
Query: 1728 CDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPL 1786
CDP N S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPL
Sbjct: 1730 CDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPL 1789
Query: 1787 SEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGD 1846
SEDDF+MFYE+WEKFDP+ATQF+E+ LS FA AL PL + +PN++ LI MDLPMVSGD
Sbjct: 1790 SEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGD 1849
Query: 1847 RIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAM 1906
RIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SY+PITTTL+RK EEVSA+
Sbjct: 1850 RIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAV 1909
Query: 1907 VIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSS 1966
+IQRA+RRHLL+R++K ASF + + G + +E +I ++EN + +
Sbjct: 1910 IIQRAYRRHLLKRTVKQASFTYNKNKIKG--GANLLIKEDMIIDRINEN---SITEKTDL 1964
Query: 1967 SISSTSFPPSYDSVTRATSDNLQVRGSD 1994
++S+ + PPSYD VT+ + + G D
Sbjct: 1965 TMSTAACPPSYDRVTKPIVEKHEQEGKD 1992
>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
sapiens]
Length = 1956
Score = 2378 bits (6163), Expect = 0.0
Identities = 1262/2021 (62%), Positives = 1486/2021 (73%), Gaps = 112/2021 (5%)
Query: 10 TSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYG 69
T++FRRFT ESL IEK++A KQ ++ RE +EE PRPQLDL+A +LP YG
Sbjct: 10 TNNFRRFTPESLVEIEKQIAAKQGTKKAR-EKHREQKDQEEKPRPQLDLKACNQLPKFYG 68
Query: 70 NPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILV 129
P ELIGEPLEDLDPFYST +TF+VLNKG+TI RFSAT AL++ SPF+ IRR A+K+ V
Sbjct: 69 ELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSV 128
Query: 130 HSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFL 189
HS F++ I TIL NCV M + D P + +EY FT IYTFE+L+KILARGFCL+ FT+L
Sbjct: 129 HSWFSLFITVTILVNCVCMTRTDLP---EKIEYVFTVIYTFEALIKILARGFCLNEFTYL 185
Query: 190 RDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKK 249
RDPWNWLDFSVI +AYV I L +S LRTFRVLRALKT+SVIPGLK IVGALI SVKK
Sbjct: 186 RDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKK 245
Query: 250 LADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLS 309
LADV +LT+FCLSVFAL+GLQLF GNL++KCV+N A+N T Y S
Sbjct: 246 LADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTN--------------YSS 291
Query: 310 D--PENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFR 367
P+ Y+ K GTSD LLCGN SD+G CP+GY CLK +NPD YTSFDSFAWAFL+LFR
Sbjct: 292 HRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFR 351
Query: 368 LMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAET 427
LMTQD WERLYQQTLR++GKIYMIFF+LVIFLGSFYLVNLILAVV MAYEEQNQAT E
Sbjct: 352 LMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEI 411
Query: 428 EEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTE 487
E KEK+FQEA+EML+KE E L G+DT S S SPL N+ ERR + + R+S G+
Sbjct: 412 EAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGST 471
Query: 488 ECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR--RDLGSEADFAD 545
E +++ P+SD + R M+ L L G K R+S GS+F FR RD+ D
Sbjct: 472 E--DNKSPRSDPYN-QRRMSFLGLASG------KRRASHGSVFHFRSPGRDISLPEGVTD 522
Query: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLG 605
D G+ ESH SLL+ GQ P +P L
Sbjct: 523 D-GVFPGDHESHRGSLLLG------GGAGQQGPLPRSP-------------------LPQ 556
Query: 606 AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665
+P++ P E P S G + A +D EP QRA+S
Sbjct: 557 PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLD---EPFRAQRAMSV 613
Query: 666 VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725
VS++TS LEELEES KCPPC L+Q+YLIW+CCP+W+ +K + +V DPF +LTIT+
Sbjct: 614 VSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITL 673
Query: 726 CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785
CIV+NT+FMA+EH+ M+ FE MLQ+GN+VFT FTAEM FKIIA DPYYYFQ+ WNIFD
Sbjct: 674 CIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFD 733
Query: 786 SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
IIV +SL+ELG+++ +LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT++
Sbjct: 734 CIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTII 793
Query: 846 LAIIVFIFAVVGMQLFGKNYSELRDSDSGL---LPRWHMMDFFHAFLIIFRILCGEWIET 902
LAIIVF+FA+VG QL G+NY R + S PRWHM DFFH+FLI+FRILCGEWIE
Sbjct: 794 LAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIEN 853
Query: 903 MWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLA 962
MW CMEV +S+CL++FL VMV+GNLVVLNLF+ALLL+SFSADNLTAP++D E+NNLQ+A
Sbjct: 854 MWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVA 913
Query: 963 LARIQRGLRFVKRTTWDFCCGLLRQRP-QKPAALAAQGQLPSCIATPYSPPPPETEKVPP 1021
LARIQ F RT C R P +P A + + P S E
Sbjct: 914 LARIQV---FGHRTKQALCSFFSRSCPFPQPKA-----EPELVVKLPLSSSKAENHIAAN 965
Query: 1022 TRKETRFEEGEQPGQGTPGDPEP------------VCVPIAVAESDTDDQEEDEENSLGT 1069
T + G G P P V VPIA ESD DD E+D G
Sbjct: 966 TAR------GSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDD-----GG 1014
Query: 1070 EEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQA-DWRQQWKAE--PQAP 1126
E+ S QQE P + R ++ + +S A + WK E PQ P
Sbjct: 1015 EDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVP 1074
Query: 1127 GCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQA 1186
G + S SEGST D + E+L +IP+L D+++P+DCFTEGC+R CPCC +DTT++
Sbjct: 1075 AEG-VDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKS 1133
Query: 1187 PGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMF 1246
P V W++RKTCY IVEHSWFE+FIIFMILLSSG+LAFED YL+++ T+K LLEY D++F
Sbjct: 1134 PWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVF 1193
Query: 1247 TYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLR 1306
T++FV EMLLKWVAYGFKKYFTNAWCWLDFLIV++SL+SL A L ++E+ PIK+LRTLR
Sbjct: 1194 TFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLR 1253
Query: 1307 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQ 1366
ALRPLRALSRFEGMRVVV+ALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF RCIN
Sbjct: 1254 ALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINY 1313
Query: 1367 TEGDLPL-NYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
T+G+ L +IVNNKS C+ N TG +W VKVNFDNV GYLALLQVATFKGWMDIM
Sbjct: 1314 TDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIM 1373
Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
YAAVDSR QP+WE N+YMY+YFVIFIIFG FFTLNLF+GVIIDNFNQQKKKLGGQDI
Sbjct: 1374 YAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDI 1433
Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTM 1545
FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK+QGF+FDIVT+QAFD+TIM LICLNM+TM
Sbjct: 1434 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITM 1493
Query: 1546 MVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVG 1605
MVETDDQS EK IL KIN FVA+FTGEC++K+ ALR YYFTN WN+FDF+VV+LSI
Sbjct: 1494 MVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIAS 1553
Query: 1606 TVLSDIIQKY--FFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLL 1663
+ S I++ +FSPTLFRVIRLARIGRILRLIR AKGIRTLLFALMMSLPALFNIGLL
Sbjct: 1554 LIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLL 1613
Query: 1664 LFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1723
LFLVMFIYSIFGM++F +V+WEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT
Sbjct: 1614 LFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1673
Query: 1724 GPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEEST 1783
GPPYCDP LPNSNG+RGDCGSPAVGI+FFTTYIIISFLI+VNMYIA+ILENF+VATEEST
Sbjct: 1674 GPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEEST 1733
Query: 1784 EPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMV 1843
EPLSEDDFDMFYE WEKFDPEATQFI +S LSDFAD LS PLRI KPN+ LI MDLP+V
Sbjct: 1734 EPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLV 1793
Query: 1844 SGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEV 1903
GD+IHC+DILFAFTK VLGESGE+D+LK MEEKFMA N SK SYEPI TTLR K E++
Sbjct: 1794 PGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDI 1853
Query: 1904 SAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPE--REGLIAYVMSENFSRPLG 1961
SA VIQ+A+R ++L RS+ ++ +A EE+A EG +A+ +EN +
Sbjct: 1854 SATVIQKAYRSYVLHRSMALSNTPCVPRA-----EEEAASLPDEGFVAFTANENC---VL 1905
Query: 1962 PPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLA 2002
P S + S+TSFPPSY+SVTR SD + +R S +ED A
Sbjct: 1906 PDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEA 1946
>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
[Homo sapiens]
Length = 1951
Score = 2377 bits (6161), Expect = 0.0
Identities = 1268/2062 (61%), Positives = 1501/2062 (72%), Gaps = 211/2062 (10%)
Query: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
L+P G SFR FTRESLAAIEKR AE++A+ Q++ +E P+P DL+A K L
Sbjct: 6 LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
Query: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
P +YG+ P E++ EPLEDLDP+Y +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 62 PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
+KILVHSLF+MLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KILARGFCL
Sbjct: 122 IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
Query: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 182 DFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++ N T+
Sbjct: 242 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
Query: 288 NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347
NGT +V W+ Y+ D ++ + +G D LLCGN SDAG CPEGY C+KAG N
Sbjct: 302 NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
Query: 348 PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407
P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 359 PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
Query: 408 ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453
ILAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ E I G+
Sbjct: 419 ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
Query: 454 DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509
+ SS E S L+ ++ E R++R+KR G + D PKS+SED + + L
Sbjct: 479 GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
Query: 510 SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548
G TS K R+S+ SIF+FR R D+GSE DFADDE+
Sbjct: 539 FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
Query: 549 STAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGD 608
ST +SES SL VP HG++ ++ NG
Sbjct: 599 STFEDSESRRDSLFVPHR---------------------HGERRNS---NG--------- 625
Query: 609 PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
TTT +E + L+S ++ E+ RQRA+S S+
Sbjct: 626 ---------------------TTTETEVR--KRRLSSYQISMEMLEDSSGRQRAVSIASI 662
Query: 669 LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728
LT+ +EELEESR KCPPCW R A +LIW+CC W+ +K V L+VMDPF DL IT+CIV
Sbjct: 663 LTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIV 722
Query: 729 LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788
LNTLFMA+EHY MT +F +L VGNLVFTGIFTAEM KIIA+DPYYYFQ+GWNIFD II
Sbjct: 723 LNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII 782
Query: 789 VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848
V LSLMELGLS + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 783 VSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 842
Query: 849 IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906
IVFIFAVVGMQLFGK+Y E + +D LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 843 IVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 902
Query: 907 MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966
MEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+
Sbjct: 903 MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 962
Query: 967 QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026
Q+G+ +VK + C R K + ++ SC++ ++
Sbjct: 963 QKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKELNYL 1015
Query: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068
R G G GT E V VPIAV ESD ++ +E +S
Sbjct: 1016 RDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES 1075
Query: 1069 TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGC 1128
EES ++ ++AT+SSE
Sbjct: 1076 ELEESKEK---------------------LNATSSSE----------------------- 1091
Query: 1129 GETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPG 1188
GST D+ E + + +D+K PE CFTEGC+++ P C V T + G
Sbjct: 1092 ----------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEEGKG 1140
Query: 1189 KVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTY 1248
K+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+FTY
Sbjct: 1141 KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY 1200
Query: 1249 VFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRAL 1308
+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRAL
Sbjct: 1201 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
Query: 1309 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTE 1368
RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF C+N T
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT 1320
Query: 1369 GDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAA 1428
G++ + + VNN S C++L W VKVNFDNVGAGYLALLQVATFKGWMDIMYAA
Sbjct: 1321 GNM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAA 1377
Query: 1429 VDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMT 1488
VDSR + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMT
Sbjct: 1378 VDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMT 1437
Query: 1489 EEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548
EEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVE
Sbjct: 1438 EEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVE 1497
Query: 1549 TDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVL 1608
TDDQ +L++INL+F+ +FTGE ++KL +LRHYYFT WNIFDFVVVILSIVG L
Sbjct: 1498 TDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFL 1557
Query: 1609 SDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1668
+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVM
Sbjct: 1558 AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1617
Query: 1669 FIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC 1728
FIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP C
Sbjct: 1618 FIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDC 1677
Query: 1729 DP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLS 1787
DP T+ + +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLS
Sbjct: 1678 DPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLS 1737
Query: 1788 EDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDR 1847
EDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL PL IAKPN++ LI MDLPMVSGDR
Sbjct: 1738 EDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDR 1797
Query: 1848 IHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMV 1907
IHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVSA +
Sbjct: 1798 IHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAI 1857
Query: 1908 IQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSS 1967
IQR FR +LL++ LK+ S + ++A G D P ++ +I ++ N + P +
Sbjct: 1858 IQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEKTDG 1911
Query: 1968 ISSTSFPPSYDSVTRATSDNLQ 1989
SST+ PPSYDSVT+ + +
Sbjct: 1912 SSSTTSPPSYDSVTKPDKEKFE 1933
>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
[Homo sapiens]
Length = 1951
Score = 2377 bits (6160), Expect = 0.0
Identities = 1268/2062 (61%), Positives = 1501/2062 (72%), Gaps = 211/2062 (10%)
Query: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
L+P G SFR FTRESLAAIEKR AE++A+ Q++ +E P+P DL+A K L
Sbjct: 6 LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
Query: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
P +YG+ P E++ EPLEDLDP+Y +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 62 PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
+KILVHSLF+MLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KILARGFCL
Sbjct: 122 IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
Query: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 182 DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++ N T+
Sbjct: 242 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
Query: 288 NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347
NGT +V W+ Y+ D ++ + +G D LLCGN SDAG CPEGY C+KAG N
Sbjct: 302 NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
Query: 348 PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407
P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 359 PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
Query: 408 ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453
ILAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ E I G+
Sbjct: 419 ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
Query: 454 DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509
+ SS E S L+ ++ E R++R+KR G + D PKS+SED + + L
Sbjct: 479 GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
Query: 510 SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548
G TS K R+S+ SIF+FR R D+GSE DFADDE+
Sbjct: 539 FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
Query: 549 STAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGD 608
ST +SES SL VP HG++ ++ NG
Sbjct: 599 STFEDSESRRDSLFVPHR---------------------HGERRNS---NG--------- 625
Query: 609 PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
TTT +E + L+S ++ E+ RQRA+S S+
Sbjct: 626 ---------------------TTTETEVR--KRRLSSYQISMEMLEDSSGRQRAVSIASI 662
Query: 669 LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728
LT+ +EELEESR KCPPCW R A +LIW+CC W+ +K V L+VMDPF DL IT+CIV
Sbjct: 663 LTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIV 722
Query: 729 LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788
LNTLFMA+EHY MT +F +L VGNLVFTGIFTAEM KIIA+DPYYYFQ+GWNIFD II
Sbjct: 723 LNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII 782
Query: 789 VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848
V LSLMELGLS + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 783 VSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 842
Query: 849 IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906
IVFIFAVVGMQLFGK+Y E + +D LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 843 IVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 902
Query: 907 MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966
MEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+
Sbjct: 903 MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 962
Query: 967 QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026
Q+G+ +VK + C R K + ++ SC++ ++
Sbjct: 963 QKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKELNYL 1015
Query: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068
R G G GT E V VPIAV ESD ++ +E +S
Sbjct: 1016 RDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES 1075
Query: 1069 TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGC 1128
EES ++ ++AT+SSE
Sbjct: 1076 ELEESKEK---------------------LNATSSSE----------------------- 1091
Query: 1129 GETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPG 1188
GST D+ E + + +D+K PE CFTEGC+++ P C V T + G
Sbjct: 1092 ----------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEEGKG 1140
Query: 1189 KVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTY 1248
K+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+FTY
Sbjct: 1141 KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY 1200
Query: 1249 VFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRAL 1308
+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRAL
Sbjct: 1201 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
Query: 1309 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTE 1368
RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF C+N T
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT 1320
Query: 1369 GDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAA 1428
G++ + + VNN S C++L W VKVNFDNVGAGYLALLQVATFKGWMDIMYAA
Sbjct: 1321 GNM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAA 1377
Query: 1429 VDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMT 1488
VDSR + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMT
Sbjct: 1378 VDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMT 1437
Query: 1489 EEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548
EEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVE
Sbjct: 1438 EEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVE 1497
Query: 1549 TDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVL 1608
TDDQ +L++INL+F+ +FTGE ++KL +LRHYYFT WNIFDFVVVILSIVG L
Sbjct: 1498 TDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFL 1557
Query: 1609 SDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1668
+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVM
Sbjct: 1558 AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1617
Query: 1669 FIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC 1728
FIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP C
Sbjct: 1618 FIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDC 1677
Query: 1729 DP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLS 1787
DP T+ + +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLS
Sbjct: 1678 DPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLS 1737
Query: 1788 EDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDR 1847
EDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL PL IAKPN++ LI MDLPMVSGDR
Sbjct: 1738 EDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDR 1797
Query: 1848 IHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMV 1907
IHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVSA +
Sbjct: 1798 IHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAI 1857
Query: 1908 IQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSS 1967
IQR FR +LL++ LK+ S + ++A G D P ++ +I ++ N + P +
Sbjct: 1858 IQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEKTDG 1911
Query: 1968 ISSTSFPPSYDSVTRATSDNLQ 1989
SST+ PPSYDSVT+ + +
Sbjct: 1912 SSSTTSPPSYDSVTKPDKEKFE 1933
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 2350 bits (6089), Expect = 0.0
Identities = 1246/2052 (60%), Positives = 1514/2052 (73%), Gaps = 144/2052 (7%)
Query: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
L P G SF FT++SLA IE+R+AE++++ +E ++ +EEAP+P DL+A K+L
Sbjct: 4 LPPPGPQSFVHFTKQSLALIEQRIAERKSKEPK--EEKKDD--DEEAPKPSSDLEAGKQL 59
Query: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
P +YG+ P ++ EPLEDLDP+Y+ +KTFIVLNKGKTIFRF+AT ALY+LSPF P+RR +
Sbjct: 60 PFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRIS 119
Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
+KILVHSLF+MLIMCTILTNC+FM ++PP WTK VEYTFT IYTFESLVKILARGFC+
Sbjct: 120 IKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVG 179
Query: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
FTFLRDPWNWLDF VI+ AY++E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 180 EFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 239
Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESL 304
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNL+HKC RN N T S+ +L
Sbjct: 240 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESI------MNTL 293
Query: 305 DLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLA 364
+ + + G+ D LLCG S+D+G CPEGY C+K G NPD+GYTSFD+F+WAFLA
Sbjct: 294 ESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLA 353
Query: 365 LFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATI 424
LFRLMTQD WE LYQQTLR+AGK YMIFF++VIFLGSFYL+NLILAVVAMAYEEQNQA I
Sbjct: 354 LFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANI 413
Query: 425 AETEEKEKRFQEAMEMLKKEHE-------------ALTIRGVDTVSRSSLEMSPLAPVNS 471
E ++KE FQ+ ++ LKKE E ++ + +S SS E S L+ ++
Sbjct: 414 EEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSA 473
Query: 472 HERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPRAMN-HLSLT-------RGLSRTS 519
ERR++R+K+ +SSG E+ ++L KS+SED R + HL + + LS +
Sbjct: 474 KERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPN 533
Query: 520 MKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTAGESESHHTSLLVPWP 566
P S RGS+F+ RR RD+GSE +FADDE+S G++ES SL VP
Sbjct: 534 QSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHR 593
Query: 567 LRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEH 626
+ + S P ++GK +S VDCNGVVSL+ G P LL
Sbjct: 594 PQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVD-GRSALMLPNGQLL------- 645
Query: 627 PPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPC 686
P TT + + +S D +P RQRA+S S+LT+ +EELEESR KCPP
Sbjct: 646 PEGTTNQIHKK---RRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPW 702
Query: 687 WNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFE 746
W R A ++LIW C P W+ K+ + +VMDPF DL IT+CIVLNTLFMA+EH+ MT EF+
Sbjct: 703 WYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFK 762
Query: 747 EMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSV 806
+L +GNLVFTGIF AEM K+IA+DPY YFQ GWNIFDS+IV LSL+EL L+ + LSV
Sbjct: 763 NVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSV 822
Query: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
LRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y
Sbjct: 823 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 882
Query: 867 EL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMV 924
E + +D LPRWHM DFFH+FLI+FR+LCGEWIETMWDCMEV+GQ++CL+V+++VMV
Sbjct: 883 ECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMV 942
Query: 925 IGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL 984
IGNLVVLNLFLALLLSSFS+DNLTA +ED + NNLQ+A+ RI++G+ +VK+T +F
Sbjct: 943 IGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKA 1002
Query: 985 LRQRPQKPAALAAQGQLPSCIATPYSPPP-PETEKVPPTRKETRFEEG-----------E 1032
++P+ + L + S E K KE G +
Sbjct: 1003 FSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMED 1062
Query: 1033 QPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPD 1091
GQ +P V VPIA ESD ++ +E +S E
Sbjct: 1063 SDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSE-------------------- 1102
Query: 1092 SRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELL 1151
+S+V SS +E S + PG GE E A+ N+ E
Sbjct: 1103 ---YSKVRLNRSSSSECST----------VDNPLPGEGEEAE--------AEPMNSDE-- 1139
Query: 1152 EQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFI 1211
PE CFT+GCVRR CC V+ GK+WW +RKTCY IVEHSWFE+FI
Sbjct: 1140 ------------PEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFI 1187
Query: 1212 IFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAW 1271
+ MILLSSGALAFEDIY+E +KTIK++LEYADK+FTY+F+LEMLLKW+AYG+K YFTNAW
Sbjct: 1188 VLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAW 1247
Query: 1272 CWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAI 1331
CWLDFLIVDVSLV+LVANTLG++++GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAI
Sbjct: 1248 CWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAI 1307
Query: 1332 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD-LPLNYTIVNNKSQCESL-NL 1389
PSIMNVLLVCLIFWLIFSIMGVNLFAGKF CIN T+G P + V N+S+C +L N+
Sbjct: 1308 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ--VPNRSECFALMNV 1365
Query: 1390 TGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIY 1449
+ + W +KVNFDNVG GYL+LLQVATFKGW IMYAAVDS ++QP++EY+LYMYIY
Sbjct: 1366 SQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIY 1425
Query: 1450 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1509
FV+FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP
Sbjct: 1426 FVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1485
Query: 1510 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVA 1569
IPRP NK QG IFD+VT QAFD++IM LICLNMVTMMVE + QS +L IN++F+
Sbjct: 1486 IPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFII 1545
Query: 1570 IFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLAR 1629
+FTGEC++KL +LRHYYFT WNIFDFVVVI+SIVG L+D+I+ YF SPTLFRVIRLAR
Sbjct: 1546 LFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLAR 1605
Query: 1630 IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGID 1689
IGRILRL++GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK E GI+
Sbjct: 1606 IGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGIN 1665
Query: 1690 DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVG 1748
DMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP + S GDCG+P+VG
Sbjct: 1666 DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVG 1725
Query: 1749 ILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1808
I +F +YIIISFL+VVNMYIA+ILENFSVATEESTEPLSEDDF+MFYE+WEKFDP+ATQF
Sbjct: 1726 IFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQF 1785
Query: 1809 IEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEM 1868
IE+S LSDFA AL PL IAKPN++ LI MDLPMVSGDRIHC+DILFAFTKRVLGESGEM
Sbjct: 1786 IEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEM 1845
Query: 1869 DALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLF 1928
D+L+ QMEE+FM+ANPSK+SYEPITTTL+RK E+VSA VIQRA+RR+ L++++K+ S ++
Sbjct: 1846 DSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIY 1905
Query: 1929 RQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNL 1988
+ G ++D ++ + ++EN S P + + SST+ PPSYDSVT+ +
Sbjct: 1906 IK---DGDRDDDLLNKKDMAFDNVNENSS----PEKTDATSSTTSPPSYDSVTKPDKEKY 1958
Query: 1989 QVRGSDYSHSED 2000
+ D + ED
Sbjct: 1959 E---QDRTEKED 1967
>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
sapiens]
Length = 1980
Score = 2333 bits (6045), Expect = 0.0
Identities = 1274/2062 (61%), Positives = 1498/2062 (72%), Gaps = 179/2062 (8%)
Query: 2 ANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQAS 61
A L P G SF+ FT ESLA IE+R+AE + + S E+ P+P DL+A
Sbjct: 3 ARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAG 62
Query: 62 KKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIR 121
K LP +YG+ PQ L+ PLED DP+Y TQKTF+VLN+GKT+FRFSAT ALY+LSPF+ IR
Sbjct: 63 KSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIR 122
Query: 122 RAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGF 181
R A+KIL+HS+F+M+IMCTILTNCVFM +PP W+K VEYTFT IYTFESLVKI+ARGF
Sbjct: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGF 182
Query: 182 CLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVG 241
C+ FTFLRDPWNWLDFSVI+MAY++E + LGN+SALRTFRVLRALKTISVIPGLKTIVG
Sbjct: 183 CIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVG 242
Query: 242 ALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGTNGSVEADG 298
ALIQSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KCV NF NG+ G
Sbjct: 243 ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT---KG 299
Query: 299 LVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSF 358
WE Y+++ N+ G + LLCGNSSDAG CPEGY+C+KAG NP++GYTSFD+F
Sbjct: 300 FDWEE---YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTF 356
Query: 359 AWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE 418
+WAFLALFRLMTQD WE LYQ TLR+AGK YMIFF+LVIF+GSFYLVNLILAVVAMAYEE
Sbjct: 357 SWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE 416
Query: 419 QNQATIAETEEKEKRFQEAMEMLKKEHE----ALTIRGVDTVS---------------RS 459
QNQAT+ E E+KE F+ +E LKK+ E A TVS RS
Sbjct: 417 QNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS 476
Query: 460 SLEMSPLAPVNSHERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPR----------- 504
S E+S L+ ++ ERR++R+KR +S G E+ +++ KS+SEDG R
Sbjct: 477 SSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536
Query: 505 ----AMNHLSLTRGLSRTSMKPRSSRGSIFTFRR----RDLGSEADFADDENSTAGESES 556
++ + SL + +S+ SIF+FR RD GSE +FADDE+ST ESE
Sbjct: 537 GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEG 596
Query: 557 HHTSLLVPWPLR--RTSAQGQP--SPGTSA----PGHALHGKKNSTVDCNGVVSLLGAGD 608
SL +P R R+S G S G+ + P K+NSTVDCNGVVSL+G
Sbjct: 597 RRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGG-- 654
Query: 609 PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
PGSH+ ++ E + + PG +L S +D G + R S +SV
Sbjct: 655 -----PGSHIGGRLLPEATTEVEIKKKGPGS--LLVS----MDQLASYGRKDRINSIMSV 703
Query: 669 LTSAL-EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
+T+ L EELEES+ KCPPCW + A +LIWEC P W+ +K+ V L+VMDPF DL IT+CI
Sbjct: 704 VTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICI 763
Query: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
VLNTLFMA+EH+ MT +FE +L VGNLVFTGIFTAEM K+IA+DPYYYFQ+GWNIFD
Sbjct: 764 VLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGF 823
Query: 788 IVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
IV LSLMEL L+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLA
Sbjct: 824 IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA 883
Query: 848 IIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWD 905
IIVFIFAVVGMQLFGK+Y E + + LPRWHM DFFH+FLI+FR+LCGEWIETMWD
Sbjct: 884 IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWD 943
Query: 906 CMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALAR 965
CMEV+GQ++CL+VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+++ R
Sbjct: 944 CMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIR 1003
Query: 966 IQRGLRFVKRTTWDFCCGLLRQRPQ---KPAALAAQGQLPSCIATPYSPPPPETEKVPPT 1022
I++G+ + K F +QR KP + + +CIA
Sbjct: 1004 IKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKA-NCIANHTGADIHRNGDFQKN 1062
Query: 1023 RKETRFEEG--------EQPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEES 1073
T G ++ +P V VPIAV ESD ++ L TE+ S
Sbjct: 1063 GNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFEN--------LNTEDVS 1114
Query: 1074 SKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPE 1133
S+ S+ E S + D +
Sbjct: 1115 SE----------------------------SDPEGSKDKLD------------------D 1128
Query: 1134 DSCSEGSTADMTNTAELLEQIP-DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWW 1192
S SEGST D+ +E++P + ++ DP+ CFTEGCV+R CC V+ + GK WW
Sbjct: 1129 TSSSEGSTIDIKPE---VEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWW 1185
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
LRKTC+ IVEH+WFETFIIFMILLSSGALAFEDIY+E+RKTI+ +LEYADK+FTY+F+L
Sbjct: 1186 ILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFIL 1245
Query: 1253 EMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLR 1312
EMLLKW AYGF K+FTNAWCWLDFLIV VSLVSL+AN LG++E+G IKSLRTLRALRPLR
Sbjct: 1246 EMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLR 1305
Query: 1313 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLP 1372
ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK+ C N+T ++
Sbjct: 1306 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETS-EIR 1364
Query: 1373 LNYTIVNNKSQCESL---NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAV 1429
VNNK++CE L N T E+ W VK+NFDNVGAGYLALLQVATFKGWMDIMYAAV
Sbjct: 1365 FEIEDVNNKTECEKLMEGNNT-EIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAV 1423
Query: 1430 DSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1489
DSR +EQP++E N+YMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTE
Sbjct: 1424 DSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTE 1483
Query: 1490 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET 1549
EQKKYYNAMKKLGSKKPQKPIPRPLNK QG +FD VT+QAFD+ IM LICLNMVTMMVET
Sbjct: 1484 EQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVET 1543
Query: 1550 DDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLS 1609
D QS + NIL INL+FV FT EC++K+ ALRHYYFT WNIFDFVVVILSIVG L+
Sbjct: 1544 DTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLA 1603
Query: 1610 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1669
DII+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMF
Sbjct: 1604 DIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1663
Query: 1670 IYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC- 1728
I+SIFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL PILN PP C
Sbjct: 1664 IFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNR-PPDCS 1722
Query: 1729 -DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLS 1787
D P S G +GDCG+P+VGI FF +YIIISFLIVVNMYIAIILENFSVATEES +PLS
Sbjct: 1723 LDKEHPGS-GFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLS 1781
Query: 1788 EDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDR 1847
EDDF+ FYEIWEKFDP+ATQFIEY L+DFADAL PLR+ KPN I LI MDLPMVSGDR
Sbjct: 1782 EDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDR 1841
Query: 1848 IHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMV 1907
IHC+DILFAFTKRVLG+SGE+D L+ QMEE+F+A+NPSK+SYEPITTTLRRK EEVSA+V
Sbjct: 1842 IHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVV 1901
Query: 1908 IQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSS 1967
+QRA+R HL +R F+ ++ + L E RE S
Sbjct: 1902 LQRAYRGHLARR-----GFICKKTTSNKL-ENGGTHRE------------------KKES 1937
Query: 1968 ISSTSFPPSYDSVTRATSDNLQ 1989
ST+ PSYDSVT+ + Q
Sbjct: 1938 TPSTASLPSYDSVTKPEKEKQQ 1959
>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
Length = 1836
Score = 1731 bits (4484), Expect = 0.0
Identities = 894/1335 (66%), Positives = 1036/1335 (77%), Gaps = 81/1335 (6%)
Query: 655 EPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVV 714
E GA +++ S S ++ A+EELEE+ KCPP W + A + LIW CC W+ K + L+V
Sbjct: 516 EKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIV 575
Query: 715 MDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPY 774
MDPF DL IT+CIVLNTLFMA+EHY MT F+ +L VGNLVFTGIFTAEM K+IA+DPY
Sbjct: 576 MDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPY 635
Query: 775 YYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGN 834
YFQQGWNIFDSIIV LSL+ELGL+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGN
Sbjct: 636 EYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGN 695
Query: 835 SVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIF 892
SVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y E + + LPRWHM DFFH+FLI+F
Sbjct: 696 SVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVF 755
Query: 893 RILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE 952
RILCGEWIETMWDCMEV+GQ++CL VFL+VMVIGNLVVLNLFLALLLSSFSAD+L A DE
Sbjct: 756 RILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDE 815
Query: 953 DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPA-ALAAQGQLPSC-IATPYS 1010
D EMNNLQ+A+ RI+ G+ F K F GLL + P + + G+ A
Sbjct: 816 DGEMNNLQIAIGRIKLGIGFAKA----FLLGLLHGKILSPKDIMLSLGEADGAGEAGEAG 871
Query: 1011 PPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----------------VCVPIAVAES 1054
PE EK P ++ + + G P + VPIA ES
Sbjct: 872 ETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYLTIQVPIASEES 931
Query: 1055 DTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQAD 1114
D + E+E ++ E+S K QP+ G +++ S A+ + D
Sbjct: 932 DLEMPTEEETDTFSEPEDSKKPP--QPLYDG-------------NSSVCSTADYKPPEED 976
Query: 1115 WRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVR 1174
+Q + P+ + PE+CFTE CV+
Sbjct: 977 PEEQAEENPEG------------------------------------EQPEECFTEACVQ 1000
Query: 1175 RCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1234
R PC VD +Q GK WW LR+ C+ IVEH+WFETFI+FMILLSSGALAFEDIY+E+R+
Sbjct: 1001 RWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRV 1060
Query: 1235 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1294
I+ +LEYADK+FTY+F++EMLLKWVAYGFK YFTNAWCWLDFLIVDVS++SLVAN LG++
Sbjct: 1061 IRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYS 1120
Query: 1295 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1354
E+GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVN
Sbjct: 1121 ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1180
Query: 1355 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1414
LFAGKF CIN T + + + VNNKS+CESL TG++ W VKVN+DNVG GYL+LLQ
Sbjct: 1181 LFAGKFYYCINTTTSER-FDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQ 1239
Query: 1415 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1474
VATFKGWMDIMYAAVDSR EEQPQ+E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFN
Sbjct: 1240 VATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFN 1299
Query: 1475 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTI 1534
QQKKKLGG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG ++D+VTKQAFD+TI
Sbjct: 1300 QQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITI 1359
Query: 1535 MFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIF 1594
M LICLNMVTMMVETD+QS K++IL IN++F+ IFTGEC++K+ ALR YYFT WNIF
Sbjct: 1360 MILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIF 1419
Query: 1595 DFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1654
DFVVVILSIVG LSD+IQKYF SPTLFRVIRLARIGR+LRLIRGAKGIRTLLFALMMSL
Sbjct: 1420 DFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSL 1479
Query: 1655 PALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWD 1714
PALFNIGLLLFLVMFIYSIFGM+NFAYVK E+GIDDMFNF+TF NS++CLF+ITTSAGWD
Sbjct: 1480 PALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWD 1539
Query: 1715 GLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILE 1773
GLL+PILN+GPP CDP L N S +GDCG+P++GI FF +YIIISFLIVVNMYIAIILE
Sbjct: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILE 1599
Query: 1774 NFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQI 1833
NF+VATEES+EPL EDDF+MFYE WEKFDP+ATQFI YS LSDF D L EPLRIAKPN+I
Sbjct: 1600 NFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKI 1659
Query: 1834 SLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPIT 1893
LI +DLPMV GD+IHC+DILFA TK VLG+SGEMDALK MEEKFMAANPSK+SYEPIT
Sbjct: 1660 KLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPIT 1719
Query: 1894 TTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFR-QQAGSGLSEEDAPEREGLIAYVM 1952
TTL+RKHEEV A+ IQRA+RRHLLQRS+K AS+++R GSG +DAPE+EGL+A M
Sbjct: 1720 TTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSG---DDAPEKEGLLANTM 1776
Query: 1953 SENFSRPLGPPSSSS 1967
S+ + G SS S
Sbjct: 1777 SKMYGHENGNSSSPS 1791
Score = 597 bits (1539), Expect = e-170
Identities = 303/478 (63%), Positives = 362/478 (75%), Gaps = 38/478 (7%)
Query: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
L+P G R FTRESLAAIE+R E++AR LQ +++ EE +P+ DL+A K L
Sbjct: 9 LVPLGPECLRPFTRESLAAIEQRAVEEEAR----LQRNKQMEIEEPERKPRSDLEAGKNL 64
Query: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
P +YG+PP E+IG PLEDLDP+YS +KTFIVLNKGK IFRFSAT ALY+LSPF +RR A
Sbjct: 65 PMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124
Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
+K+L+H+LF+M IM TILTNCVFM DPPPW+K VEYTFT IYTFESL+KILARGFC+
Sbjct: 125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVD 184
Query: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
FTFLRDPWNWLDFSVI+MAY++E + LGN+SALRTFRVLRALKTI+VIPGLKTIVGALI
Sbjct: 185 DFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI 244
Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGL----- 299
QSVKKL+DVM+LTVFCLSVFAL+GLQLFMGNLR KCVR N TN + ++
Sbjct: 245 QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGND 304
Query: 300 ------------------VWES-----------LDLYLSDPENYLLKNGTSDVLLCGNSS 330
W S D Y+SD N+ G++D LLCGNSS
Sbjct: 305 TWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSS 364
Query: 331 DAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM 390
DAG CPEGY C+K G NP++GYTS+D+F+WAFLALFRLMTQD WE L+Q TLR+AGK YM
Sbjct: 365 DAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM 424
Query: 391 IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
IFF+++IFLGSFYL+NLILAVVAMAY EQN+AT+AE +EKE+ FQ+ +E KK E L
Sbjct: 425 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL 482
Score = 91.3 bits (225), Expect = 9e-18
Identities = 85/345 (24%), Positives = 156/345 (45%), Gaps = 61/345 (17%)
Query: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
+RRA KI+ H+ F I+ IL + +A D +Y + FT I+ E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
Query: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIKLGNLSALRTFRVLR 225
L+K +A GF ++ FT + W WLDF ++ ++ +S +LG + +LRT R LR
Sbjct: 1080 MLLKWVAYGFKVY-FT---NAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
Query: 226 ALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
L+ +S G++ +V AL+ ++ + +V+++ + +F+++G+ LF G + C+ T
Sbjct: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCINTTT 1194
Query: 286 A----LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRC 341
+ ++ N E + L+ +L+ NY
Sbjct: 1195 SERFDISEVNNKSECESLMHTGQVRWLNVKVNY--------------------------- 1227
Query: 342 LKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLG 400
+N GY S A F +M R ++ + +YM ++F++ I G
Sbjct: 1228 ----DNVGLGYLSLLQVA-TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFG 1282
Query: 401 SFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
SF+ +NL + V+ + +Q + I TEE +K++ AM+ L
Sbjct: 1283 SFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEE-QKKYYNAMKKL 1326
Score = 72.8 bits (177), Expect = 3e-12
Identities = 44/169 (26%), Positives = 87/169 (51%), Gaps = 18/169 (10%)
Query: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
+R+ ++ H+ F FI+ IL + + D + +EY FT ++ E
Sbjct: 120 VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
Query: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309
L+K +A GF + + W WLDF ++ ++A F ++G I +LRT R LR
Sbjct: 172 SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
Query: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1358
L+ ++ G++ +V AL+ ++ + +V+++ + +F+++G+ LF G
Sbjct: 226 ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
Score = 69.3 bits (168), Expect = 4e-11
Identities = 45/163 (27%), Positives = 84/163 (51%), Gaps = 11/163 (6%)
Query: 706 IKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765
+++G V++ + I + I+ N +FM + S+ E FTGI+T E
Sbjct: 120 VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESL 173
Query: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821
KI+A +D + + + WN D +++++ + + + N+S LR+FR+LR K
Sbjct: 174 IKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD-LGNISALRTFRVLRALKTITV 232
Query: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864
P L T++ + SV L ++ ++ + +FA+VG+QLF N
Sbjct: 233 IPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGN 275
Score = 61.6 bits (148), Expect = 7e-09
Identities = 43/163 (26%), Positives = 83/163 (50%), Gaps = 14/163 (8%)
Query: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE-------YTFTAIYTFESLVKILAR 179
I++ ++ I I+ N +FMA + P T++ + FT I+T E ++K++A
Sbjct: 574 IVMDPFVDLGITICIVLNTLFMAM-EHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA- 631
Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI-KLGNLSALRTFRVLRALKTISVIPGLKT 238
+ + + + WN D ++ ++ V + + LS LR+FR+LR K P L
Sbjct: 632 ---MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNM 688
Query: 239 IVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281
++ + SV L ++ ++ + +FA++G+QLF G +CV
Sbjct: 689 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
Score = 46.6 bits (109), Expect = 2e-04
Identities = 73/278 (26%), Positives = 115/278 (41%), Gaps = 49/278 (17%)
Query: 99 GKTIFR-------FSATNALYVLSPFHPIRRAAVKI--LVHSL-----FNMLIMCTILTN 144
GK IF ++A L P PI R KI +V+ L F++ IM I N
Sbjct: 1307 GKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLN 1366
Query: 145 CV-FMAQHDPPPWTKY-----VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDF 198
V M + D K + F I+T E ++K+LA L + F WN DF
Sbjct: 1367 MVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLA----LRQYYFTVG-WNIFDF 1421
Query: 199 SVIIMAYVSENIKLGNL-----------SALRTFRVLRALKTISVIPGLKTIVGALIQSV 247
V+I++ V + L +L +R R+ R L+ I G++T++ AL+ S+
Sbjct: 1422 VVVILSIV--GLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSL 1479
Query: 248 KKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGT-------NGSVEAD 297
L ++ +L + ++++ G+ F + + NF + S D
Sbjct: 1480 PALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWD 1539
Query: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTC 335
GL+ L+ D + L GTS CGN S G C
Sbjct: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPS-IGIC 1576
Score = 39.3 bits (90), Expect = 0.039
Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 10/100 (10%)
Query: 1401 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFF 1460
++D +LAL ++ T W ++ + + G YM I+FV+ I GSF+
Sbjct: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG---------KTYM-IFFVVIIFLGSFY 437
Query: 1461 TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
+NL + V+ + +Q + +D EE ++ KK
Sbjct: 438 LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
Score = 38.9 bits (89), Expect = 0.051
Identities = 17/72 (23%), Positives = 41/72 (56%)
Query: 884 FFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
F AFL +FR++ ++ E ++ + ++ F++++ +G+ ++NL LA++ +++
Sbjct: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
Query: 944 ADNLTAPDEDRE 955
N ED+E
Sbjct: 452 EQNEATLAEDKE 463
>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
sapiens]
Length = 1791
Score = 1375 bits (3559), Expect = 0.0
Identities = 739/1330 (55%), Positives = 927/1330 (69%), Gaps = 74/1330 (5%)
Query: 616 SHLLRPVMLEHPPDTTTPSEEPGGPQMLT-----SQAPCVDGFEEPG---ARQRALSAVS 667
S LR + PP + + + PQ+L SQ +D F+E G RQRALSAVS
Sbjct: 468 SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVS 527
Query: 668 VLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
+LT ++E E+S+ C PC LA +YL+W CCP W+ +K+ ++ V+ DPFT+L IT+CI
Sbjct: 528 ILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICI 587
Query: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
++NT+F+A+EH+ M + FE+ML +GNLVFT IF AEM KIIALDPY+YF++GWNIFDSI
Sbjct: 588 IINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSI 647
Query: 788 IVILSLMELGLSRMSNLS--VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
+ +LS ++ + S LRSFR+LRVFKLAKSWPTLNTLIKIIGNSVGALG+LT+V
Sbjct: 648 VALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVV 707
Query: 846 LAIIVFIFAVVGMQLFGKNYSELRDSDS--------GLLPRWHMMDFFHAFLIIFRILCG 897
L I++FIF+VVGMQLFG++++ + L WHM DF+H+FL++FRILCG
Sbjct: 708 LVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCG 767
Query: 898 EWIETMWDCMEVSG--QSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE-DR 954
EWIE MW+CM+ + SLC++VF+L+ VIG LVVLNLF+ALLL+SFS + E +
Sbjct: 768 EWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEA 827
Query: 955 EMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQR---PQKPAALAAQGQLPSCIATPYSP 1011
+QLAL R +R FV+ T FC R++ QK A Q I P
Sbjct: 828 RKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDII-----P 882
Query: 1012 PPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEE 1071
E ++ T++E G D + P+A E D + ED + E
Sbjct: 883 LVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLA-PLAEEEDDVEFSGEDNAQRITQPE 941
Query: 1072 ESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGET 1131
+ E + P S+ V SE E + D R++
Sbjct: 942 PEQQAYELHQEN----KKPTSQRVQSVEIDMFSEDEPHLTIQDPRKK-----------SD 986
Query: 1132 PEDSCSEGSTADMTNTAELL-EQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKV 1190
SE ST D+ + L E +P K PE C +G PCC+VD + P +
Sbjct: 987 VTSILSECSTIDLQDGFGWLPEMVPK-----KQPERCLPKGFGCCFPCCSVDKRKPPWVI 1041
Query: 1191 WWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVF 1250
WW LRKTCY IV+HSWFE+FIIF+ILLSSGAL FED++LE + I+ LL D +FT++F
Sbjct: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101
Query: 1251 VLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRP 1310
+LEM+LKWVA+GF KYFT+AWC LDF+IV VS+ +L+ + +KS RTLRALRP
Sbjct: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRP 1154
Query: 1311 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD 1370
LRALS+FEGM+VVVNAL+GAIP+I+NVLLVCLIFWL+F I+GV F+GKFG+CIN T D
Sbjct: 1155 LRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT--D 1212
Query: 1371 LPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1430
+NYTI+ NKSQCES G W KVNFDNVG YLALLQVATFKGWMDI+YAAVD
Sbjct: 1213 SVINYTIITNKSQCES----GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVD 1268
Query: 1431 SRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE 1490
S E+QP++E N YIYFV+FIIFGSFFTLNLFIGVIIDNFNQQ+KKLGGQDIFMTEE
Sbjct: 1269 STEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEE 1328
Query: 1491 QKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETD 1550
QKKYYNAMKKLGSKKPQKPIPRPLNK QG +FDIVT Q FD+ I+ LI LNM++MM E+
Sbjct: 1329 QKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESY 1388
Query: 1551 DQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSD 1610
+Q +IL +N +FV IFT EC++K+ ALR YYFTN WN+FD VVV+LSIV T++S
Sbjct: 1389 NQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMIST 1448
Query: 1611 IIQKYF--FSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1668
+ + F PTLFR++RLARIGRILRL+R A+GIRTLLFALMMSLP+LFNIGLLLFL+M
Sbjct: 1449 LENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIM 1508
Query: 1669 FIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC 1728
FIY+I GM F+ V E+GIDD+FNF+TFA+SMLCLFQI+TSAGWD LLSP+L
Sbjct: 1509 FIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLR------ 1562
Query: 1729 DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSE 1788
+ + N S +C P + +F +YIIISFLIVVNMYIA+ILENF+ ATEES +PL E
Sbjct: 1563 --SKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGE 1620
Query: 1789 DDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRI 1848
DDFD+FYE+WEKFDPEATQFI+YS LSDFADAL EPLR+AKPN+ + MDLPMVS DR+
Sbjct: 1621 DDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRL 1680
Query: 1849 HCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVI 1908
HCMDILFAFT RVLG S +D++K MEEKFM ANP K YEPI TT +RK EE A +I
Sbjct: 1681 HCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAII 1740
Query: 1909 QRAFRRHLLQ 1918
Q+AFR+++++
Sbjct: 1741 QKAFRKYMMK 1750
Score = 453 bits (1166), Expect = e-127
Identities = 259/517 (50%), Positives = 335/517 (64%), Gaps = 39/517 (7%)
Query: 12 SFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNP 71
+FR FT +SLAAIEKR+A ++ + ++S++ E PRPQLDL+AS+KLP LYG+
Sbjct: 15 NFRPFTSDSLAAIEKRIAIQKEK-----KKSKDQTGEVPQPRPQLDLKASRKLPKLYGDI 69
Query: 72 PQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHS 131
P+ELIG+PLEDLDPFY KTF+VLN+ +TI+RFSA +AL++ PF+ IR A+++ VHS
Sbjct: 70 PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
Query: 132 LFNMLIMCTILTNCVFMA----QHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFT 187
LF+M I+ T++ NCVFMA ++ T E FT IY FE+L+KILARGF L F+
Sbjct: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
Query: 188 FLRDPWNWLDFSVIIMAYVS--ENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQ 245
FLRDPWNWLD VI +A VS I + L LRTFRV RALK ISV+ LK IVGAL++
Sbjct: 190 FLRDPWNWLDSIVIGIAIVSYIPGITI-KLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248
Query: 246 SVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLD 305
SVKKL +V++LT FCLS+FAL+G QLFMG+L KC+
Sbjct: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK------------------- 289
Query: 306 LYLSDPENY----LLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWA 361
+S+PE Y K + + +CG C Y C NPD+ YT+FD+F W+
Sbjct: 290 -NISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
Query: 362 FLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQ 421
FLA+FRLMTQD WE+LYQQTLR+ G + FF++VIFLGSFYL+NL LAVV MAYEEQN+
Sbjct: 349 FLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNK 408
Query: 422 ATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKR 481
AE E KEK FQEA ++LK+E EAL G+D S +SLE S P + +KR
Sbjct: 409 NVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTP--KKRKLFGNKKR 466
Query: 482 MSSGTEECGEDRLPKSDS-EDGPRAMNHLSLTRGLSR 517
S E G+D+ P SDS ED + L T+ LS+
Sbjct: 467 KSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQ 503
Score = 100 bits (249), Expect = 1e-20
Identities = 78/337 (23%), Positives = 153/337 (45%), Gaps = 47/337 (13%)
Query: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
+R + HS F FII ++++ +A + A+ +FT +++ E
Sbjct: 118 IRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDI----AECVFTGIYIFE 173
Query: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309
L+K +A GF + + W WLD +++ +++VS + + LRT R R
Sbjct: 174 ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVFR 228
Query: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG-RCINQTE 1368
L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G +CI++
Sbjct: 229 ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDC 288
Query: 1369 GDL--PLNYTIVNNKSQ-------C------ESLNLTGELYWTKVK-----VNFDNVGAG 1408
++ P Y K + C + ++ E TK+ NFDN G
Sbjct: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
Query: 1409 YLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGV 1468
+LA+ ++ T W + + + G LY +F++ I GSF+ +NL + V
Sbjct: 349 FLAMFRLMTQDSWEKLYQQTLRTTG----------LYSVFFFIVVIFLGSFYLINLTLAV 398
Query: 1469 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1505
+ + +Q K + + + ++K + A + L +K
Sbjct: 399 VTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
Score = 83.6 bits (205), Expect = 2e-15
Identities = 82/343 (23%), Positives = 149/343 (43%), Gaps = 69/343 (20%)
Query: 120 IRRAAVKILVHSLFNMLIMCTILTNC---VFMAQH--DPPPWTKYVEYT---FTAIYTFE 171
+R+ +I+ HS F I+ IL + +F H + P + + T FT I+ E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
Query: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTIS 231
++K +A GF + W LDF ++I++ V+ I L L + RT R LR L+ +S
Sbjct: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVS-VTTLINLMELKSFRTLRALRPLRALS 1159
Query: 232 VIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTN 291
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+ NGT+
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI------NGTD 1212
Query: 292 GSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHG 351
+ NY + S +C + +
Sbjct: 1213 SVI------------------NYTIITNKS------------------QCESGNFSWINQ 1236
Query: 352 YTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLRSAGKIYMIFFMLVIFLGS 401
+FD+ A+LAL ++ T W + QQ + + I+F++ I GS
Sbjct: 1237 KVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGS 1296
Query: 402 FYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
F+ +NL + V+ + +Q + + E++K++ AM+ L
Sbjct: 1297 FFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKL 1339
Score = 82.8 bits (203), Expect = 3e-15
Identities = 155/803 (19%), Positives = 286/803 (35%), Gaps = 173/803 (21%)
Query: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWN 782
+++N +FMA ++ + VFTGI+ E KI+A LD + + + WN
Sbjct: 139 VIINCVFMATGPAKNSNS--NNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196
Query: 783 IFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 842
DSI++ ++++ L LR+FR+ R K L ++ + SV L N+
Sbjct: 197 WLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNV 256
Query: 843 TLVLAIIVFIFAVVGMQLF------------GKNYSELRDSD------------------ 872
++ + IFA+VG QLF KN S D
Sbjct: 257 IILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIW 316
Query: 873 --------------SGLLPRWHMMDFFH---AFLIIFRILCGEWIETMWDCMEVSGQSLC 915
+ + P ++ +F + +FL +FR++ + E ++ +
Sbjct: 317 MGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYS 376
Query: 916 LLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975
+ F++V+ +G+ ++NL LA++ ++ N E K
Sbjct: 377 VFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIE------------------AKE 418
Query: 976 TTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPG 1035
+ LL++ + A+ + + T Y P+ K+ +K F E
Sbjct: 419 KMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYF--TPKKRKLFGNKKRKSFFLRESGK 476
Query: 1036 QGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTW 1095
PG SD+D+ + + L + S+ + R
Sbjct: 477 DQPPG-------------SDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRAL 523
Query: 1096 SQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIP 1155
S VS + E SQ EP P CGE + + +
Sbjct: 524 SAVSILTITMKEQEKSQ---------EPCLP-CGENLASKYLVWNCCPQWLCVKKV---- 569
Query: 1156 DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMI 1215
L + DP FTE + C + T + +EH E F
Sbjct: 570 -LRTVMTDP---FTELAITIC----------------IIINTVFLAMEHHKMEA--SFEK 607
Query: 1216 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLD 1275
+L+ G L F I++ E M LK +A YF W D
Sbjct: 608 MLNIGNLVFTSIFIAE----------------------MCLKIIALDPYHYFRRGWNIFD 645
Query: 1276 FLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 1335
++ +S ++ L ++S R LR + ++ + ++ VGA+ S +
Sbjct: 646 SIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-L 704
Query: 1336 NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1395
V+LV +IF IFS++G+ LF F N++ + N TG
Sbjct: 705 TVVLVIVIF--IFSVVGMQLFGRSF------------------NSQKSPKLCNPTGPTVS 744
Query: 1396 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1455
+ + +L + ++ + W++ M+ + I F++ +
Sbjct: 745 CLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSS-------LCVIVFILITV 796
Query: 1456 FGSFFTLNLFIGVIIDNFNQQKK 1478
G LNLFI +++++F+ +++
Sbjct: 797 IGKLVVLNLFIALLLNSFSNEER 819
Score = 66.2 bits (160), Expect = 3e-10
Identities = 67/335 (20%), Positives = 134/335 (40%), Gaps = 70/335 (20%)
Query: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
+++ ++ + I I+ N VF+A + + FT+I+ E
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
Query: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSE-NIKLGNLS--ALRTFRVLRALKTI 230
+KI+A L + + R WN D V ++++ N L S LR+FRVLR K
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
Query: 231 SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGT 290
P L T++ + SV L + V+ V + +F+++G+QLF R+F
Sbjct: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF--------GRSF------ 727
Query: 291 NGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDH 350
N LC + +C +
Sbjct: 728 ---------------------------NSQKSPKLCNPTGPTVSCLRHWH---------- 750
Query: 351 GYTSFDSFAWAFLALFRLMTQDCWERLYQ--QTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
F +FL +FR++ + E +++ Q ++ + +I F+L+ +G ++NL
Sbjct: 751 ----MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLF 806
Query: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
+A++ ++ + + E E ++ + Q A++ ++
Sbjct: 807 IALLLNSFSNEERNGNLEGEARKTKVQLALDRFRR 841
Score = 55.1 bits (131), Expect = 7e-07
Identities = 42/174 (24%), Positives = 84/174 (48%), Gaps = 22/174 (12%)
Query: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA--QHDPPPWTK----YVEYTFTAIYT 169
P + + I+ +F+++I+ I+ N + M ++ P K ++ + F I+T
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK-LGN----------LSAL 218
E L+KI F L + F + WN D V++++ VS I L N +
Sbjct: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
Query: 219 RTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G+ F
Sbjct: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519
Score = 33.9 bits (76), Expect = 1.7
Identities = 64/350 (18%), Positives = 120/350 (34%), Gaps = 86/350 (24%)
Query: 1513 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1572
P N + + F + I+ + +N V M S +A+ +F I+
Sbjct: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171
Query: 1573 GECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1627
E ++K+ A + + WN D +V+ ++IV + I+ FRV R
Sbjct: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--LLPLRTFRVFRA 229
Query: 1628 AR-----------IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL------------ 1664
+ +G +LR ++ + L F +S+ AL L +
Sbjct: 230 LKAISVVSRLKVIVGALLRSVKKLVNVIILTF-FCLSIFALVGQQLFMGSLNLKCISRDC 288
Query: 1665 ---------------------FLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFAN---S 1700
F + I+ + Y I+ +N+ F N S
Sbjct: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
Query: 1701 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1760
L +F++ T W+ L L T Y + FF I +
Sbjct: 349 FLAMFRLMTQDSWEKLYQQTLRTTGLY--------------------SVFFFIVVIFLGS 388
Query: 1761 LIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIE 1810
++N+ +A++ ++A EE + ++ + E EK EA Q ++
Sbjct: 389 FYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLK 429
Score = 31.6 bits (70), Expect = 8.2
Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 18/92 (19%)
Query: 347 NPDHGYT---SFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK------------IYMI 391
NP+ G +F +FA + L LF++ T W+ L LRS I
Sbjct: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
Query: 392 FFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
+F+ I + +VN+ +AV+ E N AT
Sbjct: 1583 YFVSYIIISFLIVVNMYIAVI---LENFNTAT 1611
>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
type V, alpha (long QT syndrome 3) [Homo sapiens]
Length = 1637
Score = 1323 bits (3424), Expect = 0.0
Identities = 701/883 (79%), Positives = 721/883 (81%), Gaps = 92/883 (10%)
Query: 930 VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 989
VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP
Sbjct: 631 VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
Query: 990 QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPI 1049
QKPAALAAQGQLPSCIATPYSP PP PE VP
Sbjct: 691 QKPAALAAQGQLPSCIATPYSP--------PP--------------------PETEKVPP 722
Query: 1050 AVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEAS 1109
E+ ++ E+ + + G E P P + S E +
Sbjct: 723 TRKETRFEEGEQPGQGTPGDPE--------------PVCVPIAVAESDTDDQEEDEENSL 768
Query: 1110 ASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFT 1169
++ + +Q +++P + G P+ +A ++ AE D Q K
Sbjct: 769 GTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEP---- 824
Query: 1170 EGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYL 1229
QAPG C AFEDIYL
Sbjct: 825 ---------------QAPG---------CGE----------------------AFEDIYL 838
Query: 1230 EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN 1289
EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN
Sbjct: 839 EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN 898
Query: 1290 TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1349
TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS
Sbjct: 899 TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 958
Query: 1350 IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY 1409
IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY
Sbjct: 959 IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY 1018
Query: 1410 LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1469
LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI
Sbjct: 1019 LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1078
Query: 1470 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529
IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA
Sbjct: 1079 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1138
Query: 1530 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN 1589
FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN
Sbjct: 1139 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN 1198
Query: 1590 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1649
SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA
Sbjct: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258
Query: 1650 LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT 1709
LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT
Sbjct: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT 1318
Query: 1710 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1769
SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA
Sbjct: 1319 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1378
Query: 1770 IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1812
IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS
Sbjct: 1379 IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1421
Score = 1249 bits (3233), Expect = 0.0
Identities = 623/630 (98%), Positives = 626/630 (99%)
Query: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1 MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
Query: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61 SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630
VSLLGAGDPEATSPGSHLLRPVMLEHPPDT
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630
Score = 98.2 bits (243), Expect = 7e-20
Identities = 87/349 (24%), Positives = 157/349 (44%), Gaps = 68/349 (19%)
Query: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
+R+ I+ HS F I+ IL + +A D +Y + FT ++ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
Query: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309
L+K +A GF + + W WLDF ++ ++A T F ++G + +LRT R LR
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
Query: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCI---- 1364
L+ +S G++ +V AL+ ++ + +V+++ + +F+++G+ LF G +C+
Sbjct: 226 ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
Query: 1365 --NQTEGDL----------------PLNYTIVNNKSQ---CESLNLTG---ELY-WTKVK 1399
N T G + P NY + N S C + + G E Y K
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
Query: 1400 VN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVI 1452
N FD+ +LAL ++ T W + + S G +YM I+F++
Sbjct: 346 ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
Query: 1453 FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1501
I GSF+ +NL + V+ + +Q + + E++K++ AM+ L
Sbjct: 396 VIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
Score = 94.0 bits (232), Expect = 1e-18
Identities = 69/252 (27%), Positives = 129/252 (51%), Gaps = 34/252 (13%)
Query: 720 DLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQ 779
D+TI I LN + M +E + + E +L NL+F IFT E K+ AL +YYF
Sbjct: 1140 DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL-RHYYFTN 1198
Query: 780 GWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPTLNTLIKI 831
WNIFD ++VILS++ LS + + V+R R+ R+ +L + + TL+
Sbjct: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258
Query: 832 IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLII 891
+ S+ AL N+ L+L +++FI+++ GM N++ ++ ++G+ ++ F ++ L +
Sbjct: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVK-WEAGIDDMFNFQTFANSMLCL 1313
Query: 892 FRILCGEWIETMWDCMEVSGQSLC--------------------LLVFLLVMVIGNLVVL 931
F+I + + + +G C +L F ++I L+V+
Sbjct: 1314 FQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVV 1373
Query: 932 NLFLALLLSSFS 943
N+++A++L +FS
Sbjct: 1374 NMYIAIILENFS 1385
Score = 88.2 bits (217), Expect = 7e-17
Identities = 76/303 (25%), Positives = 140/303 (46%), Gaps = 60/303 (19%)
Query: 158 KYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIK 211
+Y + FT ++ E L+K +A GF + + W WLDF ++ ++ VS +
Sbjct: 849 EYADKMFTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 904
Query: 212 LGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQL 271
+G + +LRT R LR L+ +S G++ +V AL+ ++ + +V+++ + +F+++G+ L
Sbjct: 905 MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 964
Query: 272 FMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSD 331
F G +C+ N T G + P NY + N S C + +
Sbjct: 965 FAGKF-GRCI------NQTEGDL----------------PLNYTIVNNKSQ---CESLNL 998
Query: 332 AGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG----- 386
G E Y K N FD+ +LAL ++ T W + + S G
Sbjct: 999 TG---ELY-WTKVKVN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP 1047
Query: 387 ----KIYM-IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAM 438
+YM I+F++ I GSF+ +NL + V+ + +Q + + E++K++ AM
Sbjct: 1048 QWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAM 1107
Query: 439 EML 441
+ L
Sbjct: 1108 KKL 1110
Score = 65.5 bits (158), Expect = 5e-10
Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 83/337 (24%)
Query: 707 KQGVKLVVMDPFTDLTITMCIVL-NTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765
+ VK++V F L MC +L N +FMA +++ E FT I+T E
Sbjct: 122 RAAVKILVHSLFNMLI--MCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
Query: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821
KI+A L + + + WN D ++I++ + + N+S LR+FR+LR K
Sbjct: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGNVSALRTFRVLRALKTISV 232
Query: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF--------GKNYSEL----- 868
L T++ + SV L ++ ++ + +FA++G+QLF +N++ L
Sbjct: 233 ISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNG 292
Query: 869 -----------------------------------RDSDSGLLPRW-----------HMM 882
SD+G P H
Sbjct: 293 SVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGY 352
Query: 883 DFFHAF----LIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALL 938
F +F L +FR++ + E ++ S + ++ F+LV+ +G+ ++NL LA++
Sbjct: 353 TSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVV 412
Query: 939 LSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975
++ N E E R Q + +K+
Sbjct: 413 AMAYEEQNQATIAETEEKEK------RFQEAMEMLKK 443
Score = 63.2 bits (152), Expect = 3e-09
Identities = 50/254 (19%), Positives = 105/254 (41%), Gaps = 41/254 (16%)
Query: 748 MLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLME-----LGLSRMS 802
+L+ + +FT +F EM K +A YF W D +IV +SL+ LG + M
Sbjct: 847 LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
Query: 803 NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 862
+ LR+ R LR + + + ++ + ++ ++ N+ LV I IF+++G+ LF
Sbjct: 907 PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
Query: 863 KNYSELRDSDSGLLP--------------------------RWHMMDFFHAFLIIFRILC 896
+ + G LP + + + +L + ++
Sbjct: 967 GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
Query: 897 GE-WIETMWDCMEVSGQS---------LCLLVFLLVMVIGNLVVLNLFLALLLSSFSADN 946
+ W++ M+ ++ G + F++ ++ G+ LNLF+ +++ +F+
Sbjct: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
Query: 947 LTAPDEDREMNNLQ 960
+D M Q
Sbjct: 1087 KKLGGQDIFMTEEQ 1100
Score = 46.6 bits (109), Expect = 2e-04
Identities = 51/190 (26%), Positives = 85/190 (44%), Gaps = 27/190 (14%)
Query: 105 FSATNALYVLSPFHPIRRAAVK-------ILVHSLFNMLIMCTILTNCV-FMAQHDPPPW 156
++A L P PI R K I+ F++ IM I N V M + D
Sbjct: 1104 YNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSP 1163
Query: 157 TKY-----VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYV----S 207
K + F AI+T E +VK+ A L + F WN DF V+I++ V S
Sbjct: 1164 EKINILAKINLLFVAIFTGECIVKLAA----LRHYYFTNS-WNIFDFVVVILSIVGTVLS 1218
Query: 208 ENIKLGNLS-----ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLS 262
+ I+ S +R R+ R L+ I G++T++ AL+ S+ L ++ +L +
Sbjct: 1219 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1278
Query: 263 VFALIGLQLF 272
++++ G+ F
Sbjct: 1279 IYSIFGMANF 1288
>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
sapiens]
Length = 1682
Score = 1121 bits (2900), Expect = 0.0
Identities = 605/1259 (48%), Positives = 825/1259 (65%), Gaps = 78/1259 (6%)
Query: 674 EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLF 733
EELE+S+ CP W + A+ +LIW C P W+ +K+ V ++M PFTDL + +CI+LN F
Sbjct: 462 EELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCF 521
Query: 734 MALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSL 793
+ LEHY M+ + +L +GNLVF GIFTAEM FKIIA+ PY YFQ GWNIFDS+IV L
Sbjct: 522 LTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGL 581
Query: 794 MELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIF 853
+EL L+ ++ +++LR FR+LR+FKL K WPT L+ + NS AL +L L+L +F
Sbjct: 582 IELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFS 641
Query: 854 AVVGMQLFGKNYSEL---RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVS 910
A GM+LFGKNY E D D LPRWHM DFFH+FL +FRILCGEW+ET+WDCMEV+
Sbjct: 642 AAFGMKLFGKNYEEFVCHIDKDC-QLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVA 700
Query: 911 GQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGL 970
GQS C+ +L+V++IGNL+VL LFLAL+ S S ++TA +E+ E NLQLA+ARI++G+
Sbjct: 701 GQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGI 759
Query: 971 RFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEE 1030
+V C +T+ VP K+T
Sbjct: 760 NYV---LLKILC--------------------------------KTQNVP---KDTMDHV 781
Query: 1031 GEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGP---E 1087
E + D ++ + D ++ E++S GTE+ ++ + ESQ + P E
Sbjct: 782 NEVYVKEDISDH-----TLSELSNTQDFLKDKEKSS-GTEKNAT-ENESQSLIPSPSVSE 834
Query: 1088 APPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNT 1147
P + S + + E ++ + +++ K + S SE ST D+ +
Sbjct: 835 TVPIASGESDIENLDNKEIQSKSGDGGSKEKIK------------QSSSSECSTVDIAIS 882
Query: 1148 AELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWF 1207
E E++ G+ K GC R + GK+W +RKTC IVE++WF
Sbjct: 883 EE--EEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWF 936
Query: 1208 ETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYF 1267
+ FI + LLS+G LAFEDIY+++RKTIK+LLEYAD +FTY+F+LEMLLKW+AYGFK YF
Sbjct: 937 KCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYF 996
Query: 1268 TNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNAL 1327
+N W LDF++V V +SL+ T +K L +++ LRPLR LS+FE M+VVV AL
Sbjct: 997 SNGWYRLDFVVVIVFCLSLIGKT-----REELKPLISMKFLRPLRVLSQFERMKVVVRAL 1051
Query: 1328 VGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESL 1387
+ +NV LVCL+ WLIFSIMGV+LFAG+F CI+ T G+ + V NKS+CESL
Sbjct: 1052 IKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGE-RFPSSEVMNKSRCESL 1110
Query: 1388 NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMY 1447
+ W K+NFDNVG G+L+LLQVATF GW+ IM +A+DS QP +E N+YMY
Sbjct: 1111 LFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMY 1170
Query: 1448 IYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ 1507
YF+ FIIFG F L++ I VIIDNFN+ K KLGG +IF+T +Q+K Y +KKL + Q
Sbjct: 1171 CYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230
Query: 1508 KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLF 1567
+P+PRPLNK QGFIFD+VT QAF+V +M LIC + MM++TD QS + L IN +F
Sbjct: 1231 RPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIF 1290
Query: 1568 VAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1627
V ++T ECI+KL A R +YFT +WNIFDF+VVI SI G L + Y P+L ++I L
Sbjct: 1291 VMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILL 1350
Query: 1628 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAG 1687
+RI +LRL +G K L+ LM+SLPAL NI LL+FLVMFIY++FGM NFAYVK EAG
Sbjct: 1351 SRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAG 1410
Query: 1688 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPA 1746
I+D+ NF+TF NSMLCLFQ+ AGWDG+L I N+ CDP N RGDCG+P+
Sbjct: 1411 INDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPS 1470
Query: 1747 VGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEAT 1806
VGI +F +YI+IS+LI+VNMYI +++E ++A+++ + LSEDDF F+++W++FDP+ T
Sbjct: 1471 VGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRT 1530
Query: 1807 QFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESG 1866
Q+I+ S LSDFA AL PL +AKPN+ LI +DLPM GDRIHC+DIL AFTKRV+G+
Sbjct: 1531 QYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDV 1590
Query: 1867 EMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHAS 1925
M+ + ++E F+ ANP KI+ EPITTTL+RK E VSA +IQRA++ + L+R+ K+ S
Sbjct: 1591 RMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTS 1649
Score = 381 bits (979), Expect = e-105
Identities = 209/463 (45%), Positives = 286/463 (61%), Gaps = 36/463 (7%)
Query: 16 FTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQEL 75
FT+ES I++ +A+ T E E EE +P DL+ KKLP +YGN Q +
Sbjct: 13 FTKESFELIKQHIAK-------THNEDHE----EEDLKPTPDLEVGKKLPFIYGNLSQGM 61
Query: 76 IGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFN 134
+ EPLED+DP+Y +K TFIVLNK +TIFRF+A + L LSPF+ IRR +K+LVH F
Sbjct: 62 VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121
Query: 135 MLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWN 194
+ I+ ++L +CVFM+ + P W +E T IYTFE LVK+ ARG +F+FL DPWN
Sbjct: 122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWN 181
Query: 195 WLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVM 254
WLDFSV + + L + L+T R LR LK I + GLK++VG LI +K+L V+
Sbjct: 182 WLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVI 241
Query: 255 VLTVFCLSVFALIGLQLFMGNLRHKCVR------NFTALNGTNGSVEADGLVWESLDLYL 308
+LT+F LS+F+LIG+ LFMGNL+HKC R N T N T Y+
Sbjct: 242 ILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGN------------PYYI 289
Query: 309 SDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRL 368
+ EN+ G LLCGN +DAG CPEGY C+KAG NPD G+T+FDSF WA ALFRL
Sbjct: 290 RETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRL 349
Query: 369 MTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
M QD E LY Q L ++GK+YMIFF++V FL SFY+ +L L ++AMAYEE+ Q ++
Sbjct: 350 MAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISK 409
Query: 429 EKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
+ E +FQ+ + L++ +E D +EM +P+++
Sbjct: 410 KIEPKFQQTGKELQEGNE------TDEAKTIQIEMKKRSPIST 446
Score = 132 bits (332), Expect = 3e-30
Identities = 154/689 (22%), Positives = 291/689 (42%), Gaps = 149/689 (21%)
Query: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
+R+T ++ H +F+ FI+ +L+ ++ ++ K VL ++T+ +++
Sbjct: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNL----PKWRPVLENTLLGIYTFEILVK 162
Query: 1254 MLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRA 1313
+ + V G + + W WLDF + ++ + ++ + I +L+T R LR L+
Sbjct: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
Query: 1314 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP 1372
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G +C +
Sbjct: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQ---- 272
Query: 1373 LNYTIVNNKSQCESL-NLTGELYWTKVKVNFDNV-GAGYLALLQVATFKGWMDIMYAAV- 1429
+++ E+L N TG Y+ + NF + G Y L T G Y V
Sbjct: 273 --------ENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVK 324
Query: 1430 ------------DSRGY----------EEQPQWEYNLYMY-------IYFVIFIIFGSFF 1460
DS G+ ++ P+ Y+ +Y I+FV+ SF+
Sbjct: 325 AGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFY 384
Query: 1461 TLNLFIGVIIDNFNQQKKKLGG----------------QDIFMTEEQKKYYNAMKKLGS- 1503
+LF+G++ + ++K+++G Q+ T+E K MKK
Sbjct: 385 MASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPI 444
Query: 1504 --------------------KKPQKPIPRPLNKY----------------QGFIFDIVTK 1527
+K +K P K+ + F+ I+
Sbjct: 445 STDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMA 504
Query: 1528 QAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHY-Y 1586
D+ ++ I LN+ + +E S + +L NL+F+ IFT E I K+ A+ Y Y
Sbjct: 505 PFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGY 564
Query: 1587 FTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTL 1646
F WNIFD ++V ++ L+++ ++RL R+ RI +L + + L
Sbjct: 565 FQVGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQIL 616
Query: 1647 LFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA--YVKWEAGID-----DMFNFQTFAN 1699
+++L S AL ++ LLLF +F + FGM F Y ++ ID ++ F +
Sbjct: 617 MWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFH 676
Query: 1700 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1759
S L +F+I + L + G +C P F+ I+I
Sbjct: 677 SFLNVFRILCGEWVETLWDCMEVAGQSWCIP--------------------FYLMVILIG 716
Query: 1760 FLIVVNMYIAIILENFS----VATEESTE 1784
L+V+ +++A++ +FS V EE+ E
Sbjct: 717 NLLVLYLFLALV-SSFSSCKDVTAEENNE 744
Score = 67.8 bits (164), Expect = 1e-10
Identities = 59/240 (24%), Positives = 107/240 (44%), Gaps = 11/240 (4%)
Query: 646 QAPCVDGFEEPGARQRALSAVSVLTSALEELEE-------SRHKCPPC--WNRLAQRYLI 696
Q+ DG + +Q + S S + A+ E EE S+H C + L Q
Sbjct: 854 QSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGA 913
Query: 697 WECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNL 754
+ +W +I++ +V + + I + +L+T +A E M + +L+ ++
Sbjct: 914 SKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADM 973
Query: 755 VFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLR 814
+FT IF EM K +A YF GW D ++VI+ + L L L S + LR
Sbjct: 974 IFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLR 1033
Query: 815 VFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSG 874
++ + + +++ + + N+ LV +I IF+++G+ LF + E D SG
Sbjct: 1034 PLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSG 1093
Score = 54.7 bits (130), Expect = 9e-07
Identities = 73/350 (20%), Positives = 147/350 (42%), Gaps = 65/350 (18%)
Query: 120 IRRAAVKILVHSLFNMLI-MCTILTNC------VFMAQHDPPP-WTKYVEYTFTAIYTFE 171
IR+ KI+ ++ F I + T+L+ ++M Q +Y + FT I+ E
Sbjct: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
Query: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN-LSALRTFRVLRALKTI 230
L+K +A GF + + W LDF V+I+ +S K L L + + LR L+ +
Sbjct: 983 MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
Query: 231 SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGT 290
S +K +V ALI++ +V ++ + +F+++G+ LF G R + ++ T
Sbjct: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG-------RFYECIDPT 1091
Query: 291 NGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDH 350
+G P + ++ + LL S EN
Sbjct: 1092 SGE---------------RFPSSEVMNKSRCESLLFNES-------------MLWEN--- 1120
Query: 351 GYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFMLVIFLG 400
+FD+ FL+L ++ T + W + + S IYM +F+ I G
Sbjct: 1121 AKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFG 1180
Query: 401 SFYLVNLILAVVAMAYEEQ----NQATIAETEEKEKRFQEAMEMLKKEHE 446
F +++++ V+ + + + I T ++ K+++ +++ ++ +
Sbjct: 1181 VFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230
Score = 53.5 bits (127), Expect = 2e-06
Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 41/234 (17%)
Query: 48 EEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSA 107
E+ R + +L+ SKK+ LY +Y KTF++ N +
Sbjct: 454 EDATLRHKEELEKSKKICPLY-----------------WYKFAKTFLIWNCSPCWLKLKE 496
Query: 108 TNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-----PPWTKYVEY 162
+++PF + LI+C IL C +H P
Sbjct: 497 FVHRIIMAPFTDL--------------FLIICIILNVCFLTLEHYPMSKQTNTLLNIGNL 542
Query: 163 TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENI-KLGNLSALRTF 221
F I+T E + KI+A +H + + + WN D ++ + + + ++ LR F
Sbjct: 543 VFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLF 598
Query: 222 RVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGN 275
R+LR K P + ++ +L S L D+++L + A G++LF N
Sbjct: 599 RMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
Score = 45.4 bits (106), Expect = 5e-04
Identities = 34/156 (21%), Positives = 74/156 (47%), Gaps = 11/156 (7%)
Query: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA-- 770
V++ PF L I + ++++ +FM+L + + V GI+T E+ K+ A
Sbjct: 114 VLVHPFFQLFILISVLIDCVFMSL------TNLPKWRPVLENTLLGIYTFEILVKLFARG 167
Query: 771 --LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTL 828
+ + WN D + + ++ + S + + L++ R LR+ K+ L +L
Sbjct: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226
Query: 829 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864
+ ++ + + L + ++ + IF+++GM LF N
Sbjct: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGN 262
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 455 bits (1170), Expect = e-127
Identities = 334/1155 (28%), Positives = 569/1155 (49%), Gaps = 104/1155 (9%)
Query: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
Query: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
Query: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
Query: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
G+ P ATP S P + E + P + T +PG +
Sbjct: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
Query: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
P P + A S T NSLG S + QESQ
Sbjct: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
Query: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
E S S S E EA +S D Q A G G E G +
Sbjct: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
Query: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
A L P L D D E ++G R P C ++ ++
Sbjct: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
Query: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVS----LVSLVANTLGFAEMGPIKSLRT 1304
EM +K VA +G + Y ++W LD L+V +S LVS+V+++ G +G ++ LR
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGMLRVLRL 1382
Query: 1305 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCI 1364
LR LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC- 1441
Query: 1365 NQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDI 1424
+G+ N T NKS C + W + K NFDN+G ++L +A+ GW+DI
Sbjct: 1442 ---QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDI 1491
Query: 1425 MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQD 1484
MY +D+ G ++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1492 MYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEE 1551
Query: 1485 IFMTEEQKKYYNAMKKLGSKKPQ------KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLI 1538
E+K+ KK SK+ Q KP ++++ + + T D+ I +I
Sbjct: 1552 A-RRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVI 1610
Query: 1539 CLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDF 1596
LN+VTM +E Q P+ ++ KI N +F IF E + KL A +F + WN D
Sbjct: 1611 GLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1669
Query: 1597 VVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1654
+V+LSI+G L +I +PT+ R++R+ RI R+L+L++ A G+R LL +M +L
Sbjct: 1670 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1729
Query: 1655 PALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITT 1709
P + N+GLL L+ FI++ G+ F ++ + G+ F+ F + L LF+++T
Sbjct: 1730 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1789
Query: 1710 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1769
W+G++ L CD C + + ++F ++++ + ++VN+ IA
Sbjct: 1790 GDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIA 1837
Query: 1770 IILENFSVATEESTE 1784
+++++ + +E+ E
Sbjct: 1838 VLMKHLEESNKEAKE 1852
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
C LP L
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
M E++ ++ + L S L KY +I
Sbjct: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
Score = 125 bits (313), Expect = 5e-28
Identities = 195/923 (21%), Positives = 359/923 (38%), Gaps = 226/923 (24%)
Query: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
G F ++++P+N D VI++ V E + + G LS LRTF R ++ + ++ L
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
Query: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
++ L ++L + + D T P+ +FDS
Sbjct: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
Query: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Query: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
+ +Q A E E F + +K+ AL G
Sbjct: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
Query: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
Query: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
Query: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
Query: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
G S L R + + PP +++ +G G
Sbjct: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
Query: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
R RA + LE S + PP R+ + ++
Sbjct: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
Query: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
Query: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Query: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+ +
Sbjct: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457
Query: 878 ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
RW H +F + A + +F + + W++ M+D ++ G LL F
Sbjct: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517
Query: 920 LLVMVIGNLVVLNLFLALLLSSF 942
+ ++I VLN+F+ +++ +F
Sbjct: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
+ + S P +++ S L CG NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
Score = 103 bits (257), Expect = 2e-21
Identities = 87/364 (23%), Positives = 155/364 (42%), Gaps = 79/364 (21%)
Query: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Query: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
Query: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Query: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
F G D N SD
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454
Query: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507
Query: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565
Query: 444 EHEA 447
+ +
Sbjct: 1566 KRRS 1569
Score = 85.9 bits (211), Expect = 4e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
+++ +FQI T W+ +L G + + L+F +
Sbjct: 911 WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
++ N+ +AI++E F E S
Sbjct: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 1590 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1649
Query: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 1650 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1705
Query: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 1706 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1750
Query: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
VE G DL C E + C G
Sbjct: 1751 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1770
Query: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 1771 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1828
Query: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 1829 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1875
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 61.6 bits (148), Expect = 7e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
Score = 32.7 bits (73), Expect = 3.7
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
isoform 9 [Homo sapiens]
Length = 2273
Score = 455 bits (1170), Expect = e-127
Identities = 334/1155 (28%), Positives = 569/1155 (49%), Gaps = 104/1155 (9%)
Query: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
Query: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
Query: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
Query: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
G+ P ATP S P + E + P + T +PG +
Sbjct: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
Query: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
P P + A S T NSLG S + QESQ
Sbjct: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
Query: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
E S S S E EA +S D Q A G G E G +
Sbjct: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
Query: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
A L P L D D E ++G R P C ++ ++
Sbjct: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
Query: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVS----LVSLVANTLGFAEMGPIKSLRT 1304
EM +K VA +G + Y ++W LD L+V +S LVS+V+++ G +G ++ LR
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGMLRVLRL 1382
Query: 1305 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCI 1364
LR LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC- 1441
Query: 1365 NQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDI 1424
+G+ N T NKS C + W + K NFDN+G ++L +A+ GW+DI
Sbjct: 1442 ---QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDI 1491
Query: 1425 MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQD 1484
MY +D+ G ++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1492 MYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEE 1551
Query: 1485 IFMTEEQKKYYNAMKKLGSKKPQ------KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLI 1538
E+K+ KK SK+ Q KP ++++ + + T D+ I +I
Sbjct: 1552 A-RRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVI 1610
Query: 1539 CLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDF 1596
LN+VTM +E Q P+ ++ KI N +F IF E + KL A +F + WN D
Sbjct: 1611 GLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1669
Query: 1597 VVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1654
+V+LSI+G L +I +PT+ R++R+ RI R+L+L++ A G+R LL +M +L
Sbjct: 1670 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1729
Query: 1655 PALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITT 1709
P + N+GLL L+ FI++ G+ F ++ + G+ F+ F + L LF+++T
Sbjct: 1730 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1789
Query: 1710 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1769
W+G++ L CD C + + ++F ++++ + ++VN+ IA
Sbjct: 1790 GDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIA 1837
Query: 1770 IILENFSVATEESTE 1784
+++++ + +E+ E
Sbjct: 1838 VLMKHLEESNKEAKE 1852
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
C LP L
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
M E++ ++ + L S L KY +I
Sbjct: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
Score = 125 bits (313), Expect = 5e-28
Identities = 195/923 (21%), Positives = 359/923 (38%), Gaps = 226/923 (24%)
Query: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
G F ++++P+N D VI++ V E + + G LS LRTF R ++ + ++ L
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
Query: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
++ L ++L + + D T P+ +FDS
Sbjct: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
Query: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Query: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
+ +Q A E E F + +K+ AL G
Sbjct: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
Query: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
Query: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
Query: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
Query: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
G S L R + + PP +++ +G G
Sbjct: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
Query: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
R RA + LE S + PP R+ + ++
Sbjct: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
Query: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
Query: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Query: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+ +
Sbjct: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457
Query: 878 ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
RW H +F + A + +F + + W++ M+D ++ G LL F
Sbjct: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517
Query: 920 LLVMVIGNLVVLNLFLALLLSSF 942
+ ++I VLN+F+ +++ +F
Sbjct: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
+ + S P +++ S L CG NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
Score = 103 bits (257), Expect = 2e-21
Identities = 87/364 (23%), Positives = 155/364 (42%), Gaps = 79/364 (21%)
Query: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Query: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
Query: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Query: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
F G D N SD
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454
Query: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507
Query: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565
Query: 444 EHEA 447
+ +
Sbjct: 1566 KRRS 1569
Score = 85.9 bits (211), Expect = 4e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
+++ +FQI T W+ +L G + + L+F +
Sbjct: 911 WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
++ N+ +AI++E F E S
Sbjct: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 1590 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1649
Query: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 1650 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1705
Query: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 1706 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1750
Query: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
VE G DL C E + C G
Sbjct: 1751 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1770
Query: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 1771 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1828
Query: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 1829 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1875
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 61.6 bits (148), Expect = 7e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
Score = 32.7 bits (73), Expect = 3.7
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
isoform 10 [Homo sapiens]
Length = 2266
Score = 454 bits (1169), Expect = e-127
Identities = 332/1149 (28%), Positives = 566/1149 (49%), Gaps = 99/1149 (8%)
Query: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
Query: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
Query: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
Query: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
G+ P ATP S P + E + P + T +PG +
Sbjct: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
Query: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
P P + A S T NSLG S + QESQ
Sbjct: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
Query: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
E S S S E EA +S D Q A G G E G +
Sbjct: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
Query: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
A L P L D D E ++G R P C ++ ++
Sbjct: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
Query: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVS----LVSLVANTLGFAEMGPIKSLRT 1304
EM +K VA +G + Y ++W LD L+V +S LVS+V+++ G +G ++ LR
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGMLRVLRL 1382
Query: 1305 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCI 1364
LR LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC- 1441
Query: 1365 NQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDI 1424
+G+ N T NKS C + W + K NFDN+G ++L +A+ GW+DI
Sbjct: 1442 ---QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDI 1491
Query: 1425 MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQD 1484
MY +D+ G ++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1492 MYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEE 1551
Query: 1485 IFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVT 1544
EE K ++K K KP ++++ + + T D+ I +I LN+VT
Sbjct: 1552 ARRREE--KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVT 1609
Query: 1545 MMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILS 1602
M +E Q P+ ++ KI N +F IF E + KL A +F + WN D +V+LS
Sbjct: 1610 MAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLS 1668
Query: 1603 IVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1660
I+G L +I +PT+ R++R+ RI R+L+L++ A G+R LL +M +LP + N+
Sbjct: 1669 IMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNL 1728
Query: 1661 GLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDG 1715
GLL L+ FI++ G+ F ++ + G+ F+ F + L LF+++T W+G
Sbjct: 1729 GLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNG 1788
Query: 1716 LLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENF 1775
++ L CD C + + ++F ++++ + ++VN+ IA+++++
Sbjct: 1789 IMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1836
Query: 1776 SVATEESTE 1784
+ +E+ E
Sbjct: 1837 EESNKEAKE 1845
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
C LP L
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
M E++ ++ + L S L KY +I
Sbjct: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
Score = 125 bits (313), Expect = 5e-28
Identities = 195/923 (21%), Positives = 359/923 (38%), Gaps = 226/923 (24%)
Query: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
G F ++++P+N D VI++ V E + + G LS LRTF R ++ + ++ L
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
Query: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
++ L ++L + + D T P+ +FDS
Sbjct: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
Query: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Query: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
+ +Q A E E F + +K+ AL G
Sbjct: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
Query: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
Query: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
Query: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
Query: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
G S L R + + PP +++ +G G
Sbjct: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
Query: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
R RA + LE S + PP R+ + ++
Sbjct: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
Query: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
Query: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Query: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+ +
Sbjct: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457
Query: 878 ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
RW H +F + A + +F + + W++ M+D ++ G LL F
Sbjct: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517
Query: 920 LLVMVIGNLVVLNLFLALLLSSF 942
+ ++I VLN+F+ +++ +F
Sbjct: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
+ + S P +++ S L CG NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
Score = 103 bits (256), Expect = 2e-21
Identities = 87/361 (24%), Positives = 154/361 (42%), Gaps = 79/361 (21%)
Query: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Query: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
Query: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Query: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
F G D N SD
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454
Query: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507
Query: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565
Query: 444 E 444
+
Sbjct: 1566 K 1566
Score = 85.9 bits (211), Expect = 4e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
+++ +FQI T W+ +L G + + L+F +
Sbjct: 911 WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
++ N+ +AI++E F E S
Sbjct: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 1583 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1642
Query: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 1643 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1698
Query: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 1699 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1743
Query: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
VE G DL C E + C G
Sbjct: 1744 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1763
Query: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 1764 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1821
Query: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 1822 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1868
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 61.6 bits (148), Expect = 7e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
Score = 32.7 bits (73), Expect = 3.7
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 450 bits (1158), Expect = e-126
Identities = 322/1160 (27%), Positives = 554/1160 (47%), Gaps = 138/1160 (11%)
Query: 702 LWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFT 761
LW++ ++ +V + I M I++NTL M +E++ E L++ N+VFT +F
Sbjct: 778 LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFA 837
Query: 762 AEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821
EM K++A P Y + +NIFD IIV++S+ E+ LSVLR+FRLLRV KL +
Sbjct: 838 LEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRF 897
Query: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHM 881
P L + ++ ++ + +L + +FIF+++GM LFG +S D+ + R +
Sbjct: 898 LPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNF 957
Query: 882 MDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLS 940
A + +F+IL E W +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 958 DSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAILVE 1016
Query: 941 SFSAD---NLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA 997
F A+ N + DED+ + + + LR ++ T C L P L
Sbjct: 1017 GFQAEGDANRSDTDEDKTSVHFEEDFHK----LRELQTTELKMCS--LAVTPN--GHLEG 1068
Query: 998 QGQL--PSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESD 1055
+G L P + T +P P T K P + G + GDP
Sbjct: 1069 RGSLSPPLIMCTAATPMP--TPKSSPFLDAAPSLPDSRRGSSSSGDPP------------ 1114
Query: 1056 TDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSR--TWSQVSATASSE-------- 1105
LG ++ + + S GP SR +WS + S +
Sbjct: 1115 -----------LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGER 1163
Query: 1106 -----AEASASQADWRQQWKAEPQAPGCGETP------------------EDSCSEGSTA 1142
E S D + +A APG TP C +
Sbjct: 1164 ESLLSGEGKGSTDDEAEDGRA---APGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQ 1220
Query: 1143 DMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWW---------- 1192
+ ++ +I +D + +D + C C + P K W
Sbjct: 1221 VVALPSDFFLRIDSHREDAAELDDDSEDSC-----CLRLHKVLEPYKPQWCRSREAWALY 1275
Query: 1193 ------RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMF 1246
R R +C ++ H F+ ++ I L+ +A E ++ T +V L ++ +F
Sbjct: 1276 LFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIF 1335
Query: 1247 TYVFVLEMLLKWVAYGFKK----YFTNAWCWLDFLIVDVSLVSLV---ANTLGFAEMGPI 1299
T +FV EM++K VA G Y ++W LD L+V VSLV +V A+ G +G +
Sbjct: 1336 TAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVL 1395
Query: 1300 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1359
+ LR LR LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GV LF GK
Sbjct: 1396 RVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGK 1455
Query: 1360 FGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFK 1419
F C EG N ++ K+QC + + W + K NFDN+G ++L +++
Sbjct: 1456 FYYC----EGPDTRN---ISTKAQCRAAHYR----WVRRKYNFDNLGQALMSLFVLSSKD 1504
Query: 1420 GWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1479
GW++IMY +D+ G ++QP +N +M +YF+ F++ SFF LN+F+GV+++NF++ ++
Sbjct: 1505 GWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH 1564
Query: 1480 LGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLIC 1539
++ EE K +++ K ++P + + I + T D+ I F+IC
Sbjct: 1565 QEAEEARRREE--KRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIIC 1622
Query: 1540 LNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVV 1598
+N++TM +E +Q L N +F +F E +KL A +F + WN D +
Sbjct: 1623 VNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAI 1682
Query: 1599 VILSIVGTVLSDIIQKYF--FSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPA 1656
V+LS++G L +I +PT+ R++R+ RI R+L+L++ A G+R LL ++ +LP
Sbjct: 1683 VLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1742
Query: 1657 LFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSA 1711
+ N+GLL L+ FIY+ G+ F ++ G+ F F + L LF+++T
Sbjct: 1743 VGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGD 1802
Query: 1712 GWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGS--PAVGILFFTTYIIISFLIVVNMYIA 1769
W+G++ TL + C S PA+ ++F T+++++ ++VN+ +A
Sbjct: 1803 NWNGIMK-----------DTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVA 1851
Query: 1770 IILENFSVATEESTEPLSED 1789
+++++ + +E+ E D
Sbjct: 1852 VLMKHLEESNKEAREDAELD 1871
Score = 145 bits (366), Expect = 4e-34
Identities = 203/889 (22%), Positives = 354/889 (39%), Gaps = 190/889 (21%)
Query: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
+I+ F+ IM IL N + M P T +E + FT+++ E L+K+LA
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847
Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKL--GNLSALRTFRVLRALKTISVIPGLK 237
G ++R+P+N D +I++ V E + G LS LRTFR+LR LK + +P L+
Sbjct: 848 G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902
Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
+ L++++ +A FC + I + +G C
Sbjct: 903 RQLVVLVKTMDNVA------TFCTLLMLFIFIFSILGMHLFGC----------------- 939
Query: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
+ LK T D + PD +FDS
Sbjct: 940 ---------------KFSLKTDTGDTV-----------------------PDR--KNFDS 959
Query: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
WA + +F+++TQ+ W + + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 960 LLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
Query: 418 EQNQATIAETEEK------EKRFQEAMEM----LKKEHEALT----IRGVDTVSRSSLEM 463
+ A ++T+E E+ F + E+ LK A+T + G ++S +
Sbjct: 1020 AEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMC 1079
Query: 464 SPLAPVNSHERR----------SKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTR 513
+ P+ + + RR SSG G D+ P + P A S
Sbjct: 1080 TAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLG-DQKPPASLRSSPCAPWGPSGAW 1138
Query: 514 GLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQ 573
R+S SS G + +RR E E+ +GE + S
Sbjct: 1139 SSRRSSW---SSLGRAPSLKRRGQCGER-----ESLLSGEGKG--------------STD 1176
Query: 574 GQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTP 633
+ G +APG + + E+ P LRP L PP T
Sbjct: 1177 DEAEDGRAAPGPRATPLRRA----------------ESLDPRP--LRPAAL--PP--TKC 1214
Query: 634 SEEPGGPQMLTSQAPC-VDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ 692
+ G L S +D E A S S + LE + P W R +
Sbjct: 1215 RDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYK----PQWCRSRE 1270
Query: 693 RYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQ 750
+ ++ P + + V+ D + + I LN + +ALE ++ E L
Sbjct: 1271 AWALYLFSPQ-NRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLS 1329
Query: 751 VGNLVFTGIFTAEMTFKIIALD----PYYYFQQGWNIFDSIIVILSLMEL--------GL 798
V N +FT IF AEM K++AL + Y Q WN+ D ++V++SL+++ G
Sbjct: 1330 VSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGA 1389
Query: 799 SRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 858
+ L VLR R LR ++ P L +++ + +S+ +GN+ L+ IF ++G+
Sbjct: 1390 KILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGV 1449
Query: 859 QLF-GKNY-------------SELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE--WIET 902
QLF GK Y ++ R + + R + D L+ +L + W+
Sbjct: 1450 QLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNI 1509
Query: 903 MWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
M+D ++ G LL F+ ++I + VLN+F+ +++ +F
Sbjct: 1510 MYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558
Score = 114 bits (286), Expect = 7e-25
Identities = 81/316 (25%), Positives = 150/316 (47%), Gaps = 24/316 (7%)
Query: 674 EELEESRHKCPPCWNRLAQRYLIWECCPLWMSI---KQGVKLVVMDPFTDLTITMCIVLN 730
+E EE+R + RL +R + P + ++ + + + DL IT I +N
Sbjct: 1565 QEAEEARRREEKRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVN 1624
Query: 731 TLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVI 790
+ M++EHYN +E L+ N VFT +F E K++A +F+ WN D IV+
Sbjct: 1625 VITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVL 1684
Query: 791 LSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
LSLM + L + + + ++R R+ RV KL K + L+ + ++ +G
Sbjct: 1685 LSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1744
Query: 841 NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE-W 899
NL L+ ++ FI+A +G++LFG+ + GL +F AFL +FR+ G+ W
Sbjct: 1745 NLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNW 1804
Query: 900 IETMWDCMEVSGQ----------SLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTA 949
M D + + +L + F+ +++ V++N+ +A+L+ N A
Sbjct: 1805 NGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEA 1864
Query: 950 PDEDREMNNLQLALAR 965
++ ++L +A+
Sbjct: 1865 REDAELDAEIELEMAQ 1880
Score = 112 bits (281), Expect = 3e-24
Identities = 89/356 (25%), Positives = 170/356 (47%), Gaps = 49/356 (13%)
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK-----------YVEYTFTAIYT 169
R ++++ + F + M I+ NCV + P + + + F A +
Sbjct: 90 RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIF-AFFA 148
Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN--LSALRTFRVLRAL 227
E ++K++A G +L D WN LDF +++ + ++ N LSA+RT RVLR L
Sbjct: 149 VEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPL 207
Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV------ 281
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C
Sbjct: 208 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFV 267
Query: 282 --RNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLK----NGTSDVLL-CGNSSDAGT 334
N T L + E + E+ + S +N + K G ++ + C +A T
Sbjct: 268 RNNNLTFLRPYYQTEEGE----ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYT 323
Query: 335 CPEG----------------YRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERL 377
P+ Y ++G+ NP +G +FD+ +A++A+F+++T + W +
Sbjct: 324 QPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDI 383
Query: 378 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 433
+ + I+F+L+I +GSF+++NL L V+A + E Q E+ R
Sbjct: 384 MYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRAR 439
Score = 108 bits (270), Expect = 5e-23
Identities = 89/362 (24%), Positives = 158/362 (43%), Gaps = 79/362 (21%)
Query: 110 ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP---PPWTKYV-----E 161
ALY+ SP + R + K++ H +F+ +++ I NCV +A P P T+ V
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332
Query: 162 YTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------L 212
Y FTAI+ E +VK++A G +L+ WN LD +++++ V + L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392
Query: 213 GNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
G L LR R LR L+ IS PGLK +V LI S++ + +++++ +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452
Query: 273 MGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDA 332
G Y P+ N S
Sbjct: 1453 KGKF-----------------------------YYCEGPDT-------------RNISTK 1470
Query: 333 GTCPEG-YRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQT 381
C YR ++ N FD+ A ++LF L ++D W + QQ
Sbjct: 1471 AQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQP 1523
Query: 382 LRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEML 441
+++ +++F+ + + SF+++N+ + VV + + Q E EE +R ++ + L
Sbjct: 1524 VQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRLRRL 1581
Query: 442 KK 443
++
Sbjct: 1582 ER 1583
Score = 95.5 bits (236), Expect = 5e-19
Identities = 103/400 (25%), Positives = 168/400 (42%), Gaps = 75/400 (18%)
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
R R C +V + WFE + +I+L+ L ED+ + +LE D
Sbjct: 88 RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCN--ILEAFDAFIFA 145
Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG---PIKSL 1302
F +EM++K VA +G K Y + W LDF IV VA + ++ G + ++
Sbjct: 146 FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAI 198
Query: 1303 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-G 1361
RT+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG
Sbjct: 199 RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258
Query: 1362 RCINQTEGDLPLNYTIV---------------------NNKSQC------ESLNLTGELY 1394
RC + N T + N +C L + L
Sbjct: 259 RCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLG 318
Query: 1395 W-TKVKVNFDNVGAGYLALLQVATFK---------------GWMDIMYA------AVDSR 1432
W + + VGA A + + + +I YA +
Sbjct: 319 WEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLE 378
Query: 1433 GYEEQPQWEYNLYMYIYFVIF---IIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1489
G+ + + + + + F+ F II GSFF +NL + VI F++ K++ + M E
Sbjct: 379 GWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMRE 435
Query: 1490 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529
++ ++ + L S L KY G IF V +++
Sbjct: 436 QRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRS 475
Score = 92.0 bits (227), Expect = 5e-18
Identities = 75/289 (25%), Positives = 134/289 (46%), Gaps = 43/289 (14%)
Query: 1188 GKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFT 1247
G++W IV+ +F I+ IL+++ ++ E Y E+ + + LE ++ +FT
Sbjct: 776 GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833
Query: 1248 YVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRA 1307
+F LEMLLK +A G Y N + D +IV +S+ +V G A+ G + LRT R
Sbjct: 834 SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRL 888
Query: 1308 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQT 1367
LR L+ + +R + LV + ++ + ++F IFSI+G++LF KF +
Sbjct: 889 LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS--LKTD 946
Query: 1368 EGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYA 1427
GD T+ + K NFD++ + + Q+ T + W ++Y
Sbjct: 947 TGD-----TVPDRK-------------------NFDSLLWAIVTVFQILTQEDWNVVLY- 981
Query: 1428 AVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1476
G W +YFV + FG++ NL + ++++ F +
Sbjct: 982 ----NGMASTSSW-----AALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
Score = 91.3 bits (225), Expect = 9e-18
Identities = 75/289 (25%), Positives = 130/289 (44%), Gaps = 40/289 (13%)
Query: 1517 YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1576
+ G + IV + F IM I +N ++M VE +Q E N L N++F ++F E +
Sbjct: 782 FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841
Query: 1577 VKLAALRHY-YFTNSWNIFDFVVVILS---IVGTVLSDIIQKYFFSPTLFRVIRLARIGR 1632
+KL A Y N +NIFD ++V++S IVG + V+R R+ R
Sbjct: 842 LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLR 890
Query: 1633 ILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA---YVKWEAG-- 1687
+L+L+R +R L L+ ++ + LL L +FI+SI GM F +K + G
Sbjct: 891 VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950
Query: 1688 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAV 1747
+ D NF + +++ +FQI T W+ +L G + +
Sbjct: 951 VPDRKNFDSLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSW 990
Query: 1748 GILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYE 1796
L+F + ++ N+ +AI++E F + + ED + +E
Sbjct: 991 AALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
Score = 70.9 bits (172), Expect = 1e-11
Identities = 40/173 (23%), Positives = 89/173 (51%), Gaps = 21/173 (12%)
Query: 117 FHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTF 170
+ P RR+ + ++ I I N + M+ +H P + KY Y FT ++ F
Sbjct: 1597 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1656
Query: 171 ESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSA-----------LR 219
E+ +K++A GF F +D WN LD ++++++ + ++ +SA +R
Sbjct: 1657 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1712
Query: 220 TFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
R+ R LK + + G++ ++ ++Q++ ++ ++ +L + ++A +G++LF
Sbjct: 1713 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1765
Score = 67.0 bits (162), Expect = 2e-10
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 713 VVMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKI 768
+V +P+ + + I+LN +F E SE +L+ + F EM K+
Sbjct: 96 LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
Query: 769 IALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPT 824
+AL + Y WN D IV+ +ME L + +LS +R+ R+LR + P+
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215
Query: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
+ L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
Score = 63.9 bits (154), Expect = 1e-09
Identities = 49/165 (29%), Positives = 76/165 (46%), Gaps = 15/165 (9%)
Query: 1524 IVTKQAFDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKL 1579
+V F+ M +I LN VT+ + E + E+ NIL + A F E ++K+
Sbjct: 96 LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
Query: 1580 AALRHY----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1635
AL + Y ++WN DF +V+ ++ L IR R+ R LR
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDG-------HNVSLSAIRTVRVLRPLR 208
Query: 1636 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
I +R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 209 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
Score = 50.4 bits (119), Expect = 2e-05
Identities = 28/97 (28%), Positives = 48/97 (49%), Gaps = 14/97 (14%)
Query: 346 ENPDHG---YTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK-----------IYMI 391
+NP G + +F +F AFL LFR+ T D W + + TLR + + +
Sbjct: 1773 DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPV 1832
Query: 392 FFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
+F+ + + F LVN+++AV+ EE N+ + E
Sbjct: 1833 YFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAE 1869
Score = 32.7 bits (73), Expect = 3.7
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 366 YAWIAIFQVITLEGWVDIMYYVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 423
>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
isoform 1 [Homo sapiens]
Length = 2377
Score = 449 bits (1156), Expect = e-125
Identities = 334/1165 (28%), Positives = 568/1165 (48%), Gaps = 113/1165 (9%)
Query: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
Query: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
Query: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
Query: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
G+ P ATP S P + E + P + T +PG +
Sbjct: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
Query: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
P P + A S T NSLG S + QESQ
Sbjct: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
Query: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
E S S S E EA +S D Q A G G E G +
Sbjct: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
Query: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
A L P L D D E ++G R P C ++ ++
Sbjct: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
Query: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVS----LVSLVANTLGFAEMGPIKSLRT 1304
EM +K VA +G + Y ++W LD L+V +S LVS+V+++ G +G ++ LR
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGMLRVLRL 1382
Query: 1305 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCI 1364
LR LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC- 1441
Query: 1365 NQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDI 1424
+G+ N T NKS C + W + K NFDN+G ++L +A+ GW+DI
Sbjct: 1442 ---QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDI 1491
Query: 1425 MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQD 1484
MY +D+ G ++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1492 MYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEE 1551
Query: 1485 IFMTEE------QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQ 1528
EE +KK N M S+ KP ++++ + + T
Sbjct: 1552 ARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSH 1611
Query: 1529 AFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYY 1586
D+ I +I LN+VTM +E Q P+ ++ KI N +F IF E + KL A +
Sbjct: 1612 YLDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRF 1670
Query: 1587 FTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIR 1644
F + WN D +V+LSI+G L +I +PT+ R++R+ RI R+L+L++ A G+R
Sbjct: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730
Query: 1645 TLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFAN 1699
LL +M +LP + N+GLL L+ FI++ G+ F ++ + G+ F+ F
Sbjct: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGM 1790
Query: 1700 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1759
+ L LF+++T W+G++ L CD C + + ++F ++++ +
Sbjct: 1791 AFLTLFRVSTGDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTA 1838
Query: 1760 FLIVVNMYIAIILENFSVATEESTE 1784
++VN+ IA+++++ + +E+ E
Sbjct: 1839 QFVLVNVVIAVLMKHLEESNKEAKE 1863
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
C LP L
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
M E++ ++ + L S L KY +I
Sbjct: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
Score = 125 bits (313), Expect = 5e-28
Identities = 195/923 (21%), Positives = 359/923 (38%), Gaps = 226/923 (24%)
Query: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
G F ++++P+N D VI++ V E + + G LS LRTF R ++ + ++ L
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
Query: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
++ L ++L + + D T P+ +FDS
Sbjct: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
Query: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Query: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
+ +Q A E E F + +K+ AL G
Sbjct: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
Query: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
Query: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
Query: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
Query: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
G S L R + + PP +++ +G G
Sbjct: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
Query: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
R RA + LE S + PP R+ + ++
Sbjct: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
Query: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
Query: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Query: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+ +
Sbjct: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457
Query: 878 ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
RW H +F + A + +F + + W++ M+D ++ G LL F
Sbjct: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517
Query: 920 LLVMVIGNLVVLNLFLALLLSSF 942
+ ++I VLN+F+ +++ +F
Sbjct: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
+ + S P +++ S L CG NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
Score = 104 bits (260), Expect = 8e-22
Identities = 89/370 (24%), Positives = 157/370 (42%), Gaps = 79/370 (21%)
Query: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Query: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
Query: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Query: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
F G D N SD
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454
Query: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507
Query: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565
Query: 444 EHEALTIRGV 453
+ L + V
Sbjct: 1566 KRRNLMLDDV 1575
Score = 85.9 bits (211), Expect = 4e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
+++ +FQI T W+ +L G + + L+F +
Sbjct: 911 WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
++ N+ +AI++E F E S
Sbjct: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 1601 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1660
Query: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 1661 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1716
Query: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 1717 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1761
Query: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
VE G DL C E + C G
Sbjct: 1762 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1781
Query: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 1782 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1839
Query: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 1840 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 61.6 bits (148), Expect = 7e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
Score = 32.7 bits (73), Expect = 3.7
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
isoform 4 [Homo sapiens]
Length = 2332
Score = 449 bits (1156), Expect = e-125
Identities = 334/1165 (28%), Positives = 568/1165 (48%), Gaps = 113/1165 (9%)
Query: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
Query: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
Query: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
Query: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
G+ P ATP S P + E + P + T +PG +
Sbjct: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
Query: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
P P + A S T NSLG S + QESQ
Sbjct: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
Query: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
E S S S E EA +S D Q A G G E G +
Sbjct: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
Query: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
A L P L D D E ++G R P C ++ ++
Sbjct: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
Query: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVS----LVSLVANTLGFAEMGPIKSLRT 1304
EM +K VA +G + Y ++W LD L+V +S LVS+V+++ G +G ++ LR
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGMLRVLRL 1382
Query: 1305 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCI 1364
LR LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC- 1441
Query: 1365 NQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDI 1424
+G+ N T NKS C + W + K NFDN+G ++L +A+ GW+DI
Sbjct: 1442 ---QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDI 1491
Query: 1425 MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQD 1484
MY +D+ G ++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1492 MYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEE 1551
Query: 1485 IFMTEE------QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQ 1528
EE +KK N M S+ KP ++++ + + T
Sbjct: 1552 ARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSH 1611
Query: 1529 AFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYY 1586
D+ I +I LN+VTM +E Q P+ ++ KI N +F IF E + KL A +
Sbjct: 1612 YLDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRF 1670
Query: 1587 FTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIR 1644
F + WN D +V+LSI+G L +I +PT+ R++R+ RI R+L+L++ A G+R
Sbjct: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730
Query: 1645 TLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFAN 1699
LL +M +LP + N+GLL L+ FI++ G+ F ++ + G+ F+ F
Sbjct: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGM 1790
Query: 1700 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1759
+ L LF+++T W+G++ L CD C + + ++F ++++ +
Sbjct: 1791 AFLTLFRVSTGDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTA 1838
Query: 1760 FLIVVNMYIAIILENFSVATEESTE 1784
++VN+ IA+++++ + +E+ E
Sbjct: 1839 QFVLVNVVIAVLMKHLEESNKEAKE 1863
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
C LP L
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
M E++ ++ + L S L KY +I
Sbjct: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
Score = 125 bits (313), Expect = 5e-28
Identities = 195/923 (21%), Positives = 359/923 (38%), Gaps = 226/923 (24%)
Query: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
G F ++++P+N D VI++ V E + + G LS LRTF R ++ + ++ L
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
Query: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
++ L ++L + + D T P+ +FDS
Sbjct: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
Query: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Query: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
+ +Q A E E F + +K+ AL G
Sbjct: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
Query: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
Query: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
Query: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
Query: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
G S L R + + PP +++ +G G
Sbjct: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
Query: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
R RA + LE S + PP R+ + ++
Sbjct: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
Query: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
Query: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Query: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+ +
Sbjct: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457
Query: 878 ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
RW H +F + A + +F + + W++ M+D ++ G LL F
Sbjct: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517
Query: 920 LLVMVIGNLVVLNLFLALLLSSF 942
+ ++I VLN+F+ +++ +F
Sbjct: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
+ + S P +++ S L CG NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
Score = 104 bits (260), Expect = 8e-22
Identities = 89/370 (24%), Positives = 157/370 (42%), Gaps = 79/370 (21%)
Query: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Query: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
Query: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Query: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
F G D N SD
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454
Query: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507
Query: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565
Query: 444 EHEALTIRGV 453
+ L + V
Sbjct: 1566 KRRNLMLDDV 1575
Score = 85.9 bits (211), Expect = 4e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
+++ +FQI T W+ +L G + + L+F +
Sbjct: 911 WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
++ N+ +AI++E F E S
Sbjct: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 1601 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1660
Query: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 1661 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1716
Query: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 1717 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1761
Query: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
VE G DL C E + C G
Sbjct: 1762 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1781
Query: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 1782 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1839
Query: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 1840 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 61.6 bits (148), Expect = 7e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
Score = 32.7 bits (73), Expect = 3.7
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
isoform 8 [Homo sapiens]
Length = 2284
Score = 449 bits (1156), Expect = e-125
Identities = 334/1165 (28%), Positives = 568/1165 (48%), Gaps = 113/1165 (9%)
Query: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
Query: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
Query: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
Query: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
G+ P ATP S P + E + P + T +PG +
Sbjct: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
Query: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
P P + A S T NSLG S + QESQ
Sbjct: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
Query: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
E S S S E EA +S D Q A G G E G +
Sbjct: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
Query: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
A L P L D D E ++G R P C ++ ++
Sbjct: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
Query: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVS----LVSLVANTLGFAEMGPIKSLRT 1304
EM +K VA +G + Y ++W LD L+V +S LVS+V+++ G +G ++ LR
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGMLRVLRL 1382
Query: 1305 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCI 1364
LR LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC- 1441
Query: 1365 NQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDI 1424
+G+ N T NKS C + W + K NFDN+G ++L +A+ GW+DI
Sbjct: 1442 ---QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDI 1491
Query: 1425 MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQD 1484
MY +D+ G ++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1492 MYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEE 1551
Query: 1485 IFMTEE------QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQ 1528
EE +KK N M S+ KP ++++ + + T
Sbjct: 1552 ARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSH 1611
Query: 1529 AFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYY 1586
D+ I +I LN+VTM +E Q P+ ++ KI N +F IF E + KL A +
Sbjct: 1612 YLDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRF 1670
Query: 1587 FTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIR 1644
F + WN D +V+LSI+G L +I +PT+ R++R+ RI R+L+L++ A G+R
Sbjct: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730
Query: 1645 TLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFAN 1699
LL +M +LP + N+GLL L+ FI++ G+ F ++ + G+ F+ F
Sbjct: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGM 1790
Query: 1700 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1759
+ L LF+++T W+G++ L CD C + + ++F ++++ +
Sbjct: 1791 AFLTLFRVSTGDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTA 1838
Query: 1760 FLIVVNMYIAIILENFSVATEESTE 1784
++VN+ IA+++++ + +E+ E
Sbjct: 1839 QFVLVNVVIAVLMKHLEESNKEAKE 1863
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
C LP L
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
M E++ ++ + L S L KY +I
Sbjct: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
Score = 125 bits (313), Expect = 5e-28
Identities = 195/923 (21%), Positives = 359/923 (38%), Gaps = 226/923 (24%)
Query: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
G F ++++P+N D VI++ V E + + G LS LRTF R ++ + ++ L
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
Query: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
++ L ++L + + D T P+ +FDS
Sbjct: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
Query: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Query: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
+ +Q A E E F + +K+ AL G
Sbjct: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
Query: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
Query: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
Query: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
Query: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
G S L R + + PP +++ +G G
Sbjct: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
Query: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
R RA + LE S + PP R+ + ++
Sbjct: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
Query: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
Query: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Query: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+ +
Sbjct: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457
Query: 878 ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
RW H +F + A + +F + + W++ M+D ++ G LL F
Sbjct: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517
Query: 920 LLVMVIGNLVVLNLFLALLLSSF 942
+ ++I VLN+F+ +++ +F
Sbjct: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
+ + S P +++ S L CG NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
Score = 104 bits (260), Expect = 8e-22
Identities = 89/370 (24%), Positives = 157/370 (42%), Gaps = 79/370 (21%)
Query: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Query: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
Query: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Query: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
F G D N SD
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454
Query: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507
Query: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565
Query: 444 EHEALTIRGV 453
+ L + V
Sbjct: 1566 KRRNLMLDDV 1575
Score = 85.9 bits (211), Expect = 4e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
+++ +FQI T W+ +L G + + L+F +
Sbjct: 911 WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950
Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
++ N+ +AI++E F E S
Sbjct: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 1601 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1660
Query: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 1661 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1716
Query: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 1717 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1761
Query: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
VE G DL C E + C G
Sbjct: 1762 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1781
Query: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 1782 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1839
Query: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 1840 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 61.6 bits (148), Expect = 7e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
Score = 32.7 bits (73), Expect = 3.7
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 449 bits (1155), Expect = e-125
Identities = 330/1145 (28%), Positives = 563/1145 (49%), Gaps = 107/1145 (9%)
Query: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
Query: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
Query: 942 FSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL--LRQRPQKPAALAAQG 999
F A+ A + E + +L G K+ C L L + P+ +L
Sbjct: 967 FQAEG-DANKSESEPDFFSPSLD----GDGDRKK-----CLALVSLGEHPELRKSL---- 1012
Query: 1000 QLPSCI----ATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QGTPGDPEPVC 1046
LP I ATP S P + E + P + T +PG + P
Sbjct: 1013 -LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPH 1071
Query: 1047 VPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVSGGPEAPPDS 1092
P + A S T NSLG S + QESQ E S
Sbjct: 1072 SPWSAASSWTS--RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERAS 1129
Query: 1093 RTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAEL 1150
S S E EA +S D Q A G G E G +A L
Sbjct: 1130 PAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1189
Query: 1151 LEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHI 1201
P L D D E ++G R P C ++ ++ R R C+ I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
Query: 1202 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1261
+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+ EM +K VA
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 1262 GF----KKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRAL 1314
G+ + Y ++W LD L+V +S++ ++ + + G +G ++ LR LR LRPLR +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 1315 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1374
SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C +G+ N
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRN 1425
Query: 1375 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1434
T NKS C + W + K NFDN+G ++L +A+ GW+DIMY +D+ G
Sbjct: 1426 IT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
Query: 1435 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1494
++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRL 1537
Query: 1495 YNAMKKLGSKKPQ------KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548
KK SK+ Q KP ++++ + + T D+ I +I LN+VTM +E
Sbjct: 1538 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1597
Query: 1549 TDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGT 1606
Q P+ ++ KI N +F IF E + KL A +F + WN D +V+LSI+G
Sbjct: 1598 -HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1607 VLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL 1664
L +I +PT+ R++R+ RI R+L+L++ A G+R LL +M +LP + N+GLL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1665 FLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSP 1719
L+ FI++ G+ F ++ + G+ F+ F + L LF+++T W+G++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1720 ILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
L CD C + + ++F ++++ + ++VN+ IA+++++ +
Sbjct: 1777 TLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1824
Query: 1780 EESTE 1784
+E+ E
Sbjct: 1825 KEAKE 1829
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
C LP L
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
M E++ ++ + L S L KY +I
Sbjct: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
Score = 136 bits (342), Expect = 2e-31
Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)
Query: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
G F ++++P+N D VI++ V E + + G LS LRTFR++R LK + +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
+ L++++ +A +L + + +F+++G+ LF + R+ L D
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907
Query: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
L+W + ++ L + + VL G +S +
Sbjct: 908 SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937
Query: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
+WA L LMT G++ L NL++A++ ++
Sbjct: 938 -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968
Query: 418 EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
+ A +E+E + +K+ AL G R SL + PL P++
Sbjct: 969 AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027
Query: 472 HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
+ S R+ SSG+ E G KS S P R +
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087
Query: 509 LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
SL R S P R S+ + ++ E + +++E ++ S+ H L
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142
Query: 569 RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
R + P T PG LH G + DCNG S L R
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188
Query: 622 VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
+ + PP +++ +G G R RA + LE S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234
Query: 682 KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
PP R+ + ++ D + + I LN + +A+E +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277
Query: 742 TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
E L + N +FT +F AEMT K++AL + Y + WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337
Query: 796 LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
+ +S +S+ L VLR R LR ++ L +++ + +S+ +GN+ ++
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397
Query: 848 IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
IF ++G+QLF + + D+ + RW H +F + A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457
Query: 893 RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
+ + W++ M+D ++ G LL F+ ++I VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
+ + S P +++ S L CG NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
Score = 115 bits (288), Expect = 4e-25
Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)
Query: 718 FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
+ DL IT I LN + MA+EHY +E L++ N +FT IF E FK++A +F
Sbjct: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637
Query: 778 QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
Q WN D IV+LS+M + L + + + ++R R+ RV KL K +
Sbjct: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697
Query: 828 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
L+ + ++ +GNL L+ ++ FIFA +G++LFG + GL +F A
Sbjct: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757
Query: 888 FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
FL +FR+ G+ W M D + + +S C + F+ ++ V++N+ +A+L+
Sbjct: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817
Query: 940 SSFSADNLTAPDEDREMNNLQLAL 963
N A +E L+L +
Sbjct: 1818 KHLEESNKEAKEEAELEAELELEM 1841
Score = 103 bits (257), Expect = 2e-21
Identities = 87/364 (23%), Positives = 155/364 (42%), Gaps = 79/364 (21%)
Query: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Query: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
Query: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Query: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
F G D N SD
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431
Query: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484
Query: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542
Query: 444 EHEA 447
+ +
Sbjct: 1543 KRRS 1546
Score = 92.4 bits (228), Expect = 4e-18
Identities = 77/318 (24%), Positives = 145/318 (45%), Gaps = 52/318 (16%)
Query: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218
D++DP RR D + +WRL T IV+ +F I+ IL++
Sbjct: 704 DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
Query: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278
+ ++ E Y E+ + + LE ++ +FT +F LEMLLK + YG Y N + D +I
Sbjct: 757 TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
Query: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338
V +S+ +V + G + LRT R +R L+ + ++ + L+ + ++
Sbjct: 815 VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
Query: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398
++ ++F IFSI+G++LF KF ++ +GD T+ + K
Sbjct: 870 MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
Query: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458
NFD++ + + Q+ T + W ++Y G W +YF+ + FG+
Sbjct: 905 --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGN 952
Query: 1459 FFTLNLFIGVIIDNFNQQ 1476
+ NL + ++++ F +
Sbjct: 953 YVLFNLLVAILVEGFQAE 970
Score = 89.0 bits (219), Expect = 4e-17
Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)
Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
+++ +FQI T W+ +L G + + L+F +
Sbjct: 911 WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1791
++ N+ +AI++E F A ++ + SE DF
Sbjct: 951 GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626
Query: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
Query: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727
Query: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
VE G DL C E + C G
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747
Query: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805
Query: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 61.6 bits (148), Expect = 7e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
Score = 32.7 bits (73), Expect = 3.7
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 449 bits (1155), Expect = e-125
Identities = 330/1145 (28%), Positives = 563/1145 (49%), Gaps = 107/1145 (9%)
Query: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
Query: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
Query: 942 FSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL--LRQRPQKPAALAAQG 999
F A+ A + E + +L G K+ C L L + P+ +L
Sbjct: 967 FQAEG-DANKSESEPDFFSPSLD----GDGDRKK-----CLALVSLGEHPELRKSL---- 1012
Query: 1000 QLPSCI----ATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QGTPGDPEPVC 1046
LP I ATP S P + E + P + T +PG + P
Sbjct: 1013 -LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPH 1071
Query: 1047 VPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVSGGPEAPPDS 1092
P + A S T NSLG S + QESQ E S
Sbjct: 1072 SPWSAASSWTS--RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERAS 1129
Query: 1093 RTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAEL 1150
S S E EA +S D Q A G G E G +A L
Sbjct: 1130 PAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1189
Query: 1151 LEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHI 1201
P L D D E ++G R P C ++ ++ R R C+ I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
Query: 1202 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1261
+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+ EM +K VA
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 1262 GF----KKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRAL 1314
G+ + Y ++W LD L+V +S++ ++ + + G +G ++ LR LR LRPLR +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 1315 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1374
SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C +G+ N
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRN 1425
Query: 1375 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1434
T NKS C + W + K NFDN+G ++L +A+ GW+DIMY +D+ G
Sbjct: 1426 IT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
Query: 1435 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1494
++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRL 1537
Query: 1495 YNAMKKLGSKKPQ------KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548
KK SK+ Q KP ++++ + + T D+ I +I LN+VTM +E
Sbjct: 1538 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1597
Query: 1549 TDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGT 1606
Q P+ ++ KI N +F IF E + KL A +F + WN D +V+LSI+G
Sbjct: 1598 -HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1607 VLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL 1664
L +I +PT+ R++R+ RI R+L+L++ A G+R LL +M +LP + N+GLL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1665 FLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSP 1719
L+ FI++ G+ F ++ + G+ F+ F + L LF+++T W+G++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1720 ILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
L CD C + + ++F ++++ + ++VN+ IA+++++ +
Sbjct: 1777 TLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1824
Query: 1780 EESTE 1784
+E+ E
Sbjct: 1825 KEAKE 1829
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
C LP L
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
M E++ ++ + L S L KY +I
Sbjct: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
Score = 136 bits (342), Expect = 2e-31
Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)
Query: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
G F ++++P+N D VI++ V E + + G LS LRTFR++R LK + +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
+ L++++ +A +L + + +F+++G+ LF + R+ L D
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907
Query: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
L+W + ++ L + + VL G +S +
Sbjct: 908 SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937
Query: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
+WA L LMT G++ L NL++A++ ++
Sbjct: 938 -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968
Query: 418 EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
+ A +E+E + +K+ AL G R SL + PL P++
Sbjct: 969 AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027
Query: 472 HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
+ S R+ SSG+ E G KS S P R +
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087
Query: 509 LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
SL R S P R S+ + ++ E + +++E ++ S+ H L
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142
Query: 569 RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
R + P T PG LH G + DCNG S L R
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188
Query: 622 VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
+ + PP +++ +G G R RA + LE S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234
Query: 682 KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
PP R+ + ++ D + + I LN + +A+E +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277
Query: 742 TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
E L + N +FT +F AEMT K++AL + Y + WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337
Query: 796 LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
+ +S +S+ L VLR R LR ++ L +++ + +S+ +GN+ ++
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397
Query: 848 IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
IF ++G+QLF + + D+ + RW H +F + A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457
Query: 893 RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
+ + W++ M+D ++ G LL F+ ++I VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
+ + S P +++ S L CG NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
Score = 115 bits (288), Expect = 4e-25
Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)
Query: 718 FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
+ DL IT I LN + MA+EHY +E L++ N +FT IF E FK++A +F
Sbjct: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637
Query: 778 QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
Q WN D IV+LS+M + L + + + ++R R+ RV KL K +
Sbjct: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697
Query: 828 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
L+ + ++ +GNL L+ ++ FIFA +G++LFG + GL +F A
Sbjct: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757
Query: 888 FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
FL +FR+ G+ W M D + + +S C + F+ ++ V++N+ +A+L+
Sbjct: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817
Query: 940 SSFSADNLTAPDEDREMNNLQLAL 963
N A +E L+L +
Sbjct: 1818 KHLEESNKEAKEEAELEAELELEM 1841
Score = 103 bits (257), Expect = 2e-21
Identities = 87/364 (23%), Positives = 155/364 (42%), Gaps = 79/364 (21%)
Query: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Query: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
Query: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Query: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
F G D N SD
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431
Query: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484
Query: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542
Query: 444 EHEA 447
+ +
Sbjct: 1543 KRRS 1546
Score = 92.4 bits (228), Expect = 4e-18
Identities = 77/318 (24%), Positives = 145/318 (45%), Gaps = 52/318 (16%)
Query: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218
D++DP RR D + +WRL T IV+ +F I+ IL++
Sbjct: 704 DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
Query: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278
+ ++ E Y E+ + + LE ++ +FT +F LEMLLK + YG Y N + D +I
Sbjct: 757 TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
Query: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338
V +S+ +V + G + LRT R +R L+ + ++ + L+ + ++
Sbjct: 815 VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
Query: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398
++ ++F IFSI+G++LF KF ++ +GD T+ + K
Sbjct: 870 MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
Query: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458
NFD++ + + Q+ T + W ++Y G W +YF+ + FG+
Sbjct: 905 --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGN 952
Query: 1459 FFTLNLFIGVIIDNFNQQ 1476
+ NL + ++++ F +
Sbjct: 953 YVLFNLLVAILVEGFQAE 970
Score = 89.0 bits (219), Expect = 4e-17
Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)
Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
+++ +FQI T W+ +L G + + L+F +
Sbjct: 911 WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1791
++ N+ +AI++E F A ++ + SE DF
Sbjct: 951 GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626
Query: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
Query: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727
Query: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
VE G DL C E + C G
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747
Query: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805
Query: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 61.6 bits (148), Expect = 7e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
Score = 32.7 bits (73), Expect = 3.7
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 449 bits (1155), Expect = e-125
Identities = 330/1145 (28%), Positives = 563/1145 (49%), Gaps = 107/1145 (9%)
Query: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
Query: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
Query: 942 FSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL--LRQRPQKPAALAAQG 999
F A+ A + E + +L G K+ C L L + P+ +L
Sbjct: 967 FQAEG-DANKSESEPDFFSPSLD----GDGDRKK-----CLALVSLGEHPELRKSL---- 1012
Query: 1000 QLPSCI----ATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QGTPGDPEPVC 1046
LP I ATP S P + E + P + T +PG + P
Sbjct: 1013 -LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPH 1071
Query: 1047 VPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVSGGPEAPPDS 1092
P + A S T NSLG S + QESQ E S
Sbjct: 1072 SPWSAASSWTS--RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERAS 1129
Query: 1093 RTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAEL 1150
S S E EA +S D Q A G G E G +A L
Sbjct: 1130 PAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1189
Query: 1151 LEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHI 1201
P L D D E ++G R P C ++ ++ R R C+ I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
Query: 1202 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1261
+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+ EM +K VA
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 1262 GF----KKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRAL 1314
G+ + Y ++W LD L+V +S++ ++ + + G +G ++ LR LR LRPLR +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 1315 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1374
SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C +G+ N
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRN 1425
Query: 1375 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1434
T NKS C + W + K NFDN+G ++L +A+ GW+DIMY +D+ G
Sbjct: 1426 IT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
Query: 1435 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1494
++QP +N +M +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRL 1537
Query: 1495 YNAMKKLGSKKPQ------KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548
KK SK+ Q KP ++++ + + T D+ I +I LN+VTM +E
Sbjct: 1538 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1597
Query: 1549 TDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGT 1606
Q P+ ++ KI N +F IF E + KL A +F + WN D +V+LSI+G
Sbjct: 1598 -HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1607 VLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL 1664
L +I +PT+ R++R+ RI R+L+L++ A G+R LL +M +LP + N+GLL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1665 FLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSP 1719
L+ FI++ G+ F ++ + G+ F+ F + L LF+++T W+G++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1720 ILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
L CD C + + ++F ++++ + ++VN+ IA+++++ +
Sbjct: 1777 TLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1824
Query: 1780 EESTE 1784
+E+ E
Sbjct: 1825 KEAKE 1829
Score = 144 bits (362), Expect = 1e-33
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
C LP L
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
M E++ ++ + L S L KY +I
Sbjct: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
Score = 136 bits (342), Expect = 2e-31
Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)
Query: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
G F ++++P+N D VI++ V E + + G LS LRTFR++R LK + +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
+ L++++ +A +L + + +F+++G+ LF + R+ L D
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907
Query: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
L+W + ++ L + + VL G +S +
Sbjct: 908 SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937
Query: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
+WA L LMT G++ L NL++A++ ++
Sbjct: 938 -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968
Query: 418 EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
+ A +E+E + +K+ AL G R SL + PL P++
Sbjct: 969 AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027
Query: 472 HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
+ S R+ SSG+ E G KS S P R +
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087
Query: 509 LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
SL R S P R S+ + ++ E + +++E ++ S+ H L
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142
Query: 569 RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
R + P T PG LH G + DCNG S L R
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188
Query: 622 VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
+ + PP +++ +G G R RA + LE S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234
Query: 682 KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
PP R+ + ++ D + + I LN + +A+E +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277
Query: 742 TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
E L + N +FT +F AEMT K++AL + Y + WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337
Query: 796 LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
+ +S +S+ L VLR R LR ++ L +++ + +S+ +GN+ ++
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397
Query: 848 IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
IF ++G+QLF + + D+ + RW H +F + A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457
Query: 893 RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
+ + W++ M+D ++ G LL F+ ++I VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
+ + S P +++ S L CG NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
Score = 115 bits (288), Expect = 4e-25
Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)
Query: 718 FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
+ DL IT I LN + MA+EHY +E L++ N +FT IF E FK++A +F
Sbjct: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637
Query: 778 QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
Q WN D IV+LS+M + L + + + ++R R+ RV KL K +
Sbjct: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697
Query: 828 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
L+ + ++ +GNL L+ ++ FIFA +G++LFG + GL +F A
Sbjct: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757
Query: 888 FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
FL +FR+ G+ W M D + + +S C + F+ ++ V++N+ +A+L+
Sbjct: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817
Query: 940 SSFSADNLTAPDEDREMNNLQLAL 963
N A +E L+L +
Sbjct: 1818 KHLEESNKEAKEEAELEAELELEM 1841
Score = 103 bits (257), Expect = 2e-21
Identities = 87/364 (23%), Positives = 155/364 (42%), Gaps = 79/364 (21%)
Query: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Query: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
Query: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Query: 275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
F G D N SD
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431
Query: 335 CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
C E YR ++ H Y +FD+ A ++LF L ++D W + QQ +
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484
Query: 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
+ +++F+ + + +F+++N+ + VV + + Q E EE +R ++ + L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542
Query: 444 EHEA 447
+ +
Sbjct: 1543 KRRS 1546
Score = 92.4 bits (228), Expect = 4e-18
Identities = 77/318 (24%), Positives = 145/318 (45%), Gaps = 52/318 (16%)
Query: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218
D++DP RR D + +WRL T IV+ +F I+ IL++
Sbjct: 704 DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
Query: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278
+ ++ E Y E+ + + LE ++ +FT +F LEMLLK + YG Y N + D +I
Sbjct: 757 TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
Query: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338
V +S+ +V + G + LRT R +R L+ + ++ + L+ + ++
Sbjct: 815 VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
Query: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398
++ ++F IFSI+G++LF KF ++ +GD T+ + K
Sbjct: 870 MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
Query: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458
NFD++ + + Q+ T + W ++Y G W +YF+ + FG+
Sbjct: 905 --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGN 952
Query: 1459 FFTLNLFIGVIIDNFNQQ 1476
+ NL + ++++ F +
Sbjct: 953 YVLFNLLVAILVEGFQAE 970
Score = 89.0 bits (219), Expect = 4e-17
Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)
Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
+++ +FQI T W+ +L G + + L+F +
Sbjct: 911 WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1791
++ N+ +AI++E F A ++ + SE DF
Sbjct: 951 GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982
Score = 70.9 bits (172), Expect = 1e-11
Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)
Query: 126 KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
++LVH L ++ I I N V MA +H P K Y FT I+ ES+
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626
Query: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
K++A GF F +D WN LD ++++++ + ++ ++A R++R L+
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
Query: 230 ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
V+ LK VG ++ L D ++ + + L+ + LF F AL
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727
Query: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
VE G DL C E + C G
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747
Query: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
+ +F +F AFL LFR+ T D W + + TLR + I I+F+ +
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805
Query: 402 FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
F LVN+++AV+ EE N+ E E + + E + + H L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 61.6 bits (148), Expect = 7e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
Score = 32.7 bits (73), Expect = 3.7
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,428,314
Number of Sequences: 37866
Number of extensions: 3719620
Number of successful extensions: 25238
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 324
Number of HSP's that attempted gapping in prelim test: 18943
Number of HSP's gapped (non-prelim): 3478
length of query: 2016
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1899
effective length of database: 13,817,196
effective search space: 26238855204
effective search space used: 26238855204
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.