Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 148596917
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148596917 fibronectin type III and ankyrin repeat domains 1
[Homo sapiens]
(345 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148596917 fibronectin type III and ankyrin repeat domains 1 [... 703 0.0
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 114 1e-25
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 109 4e-24
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 107 1e-23
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 107 2e-23
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 107 2e-23
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 106 3e-23
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 106 3e-23
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 105 5e-23
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 105 8e-23
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 105 8e-23
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 105 8e-23
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 105 8e-23
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 103 2e-22
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 103 2e-22
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 103 2e-22
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 102 5e-22
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 101 1e-21
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 100 1e-21
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 100 3e-21
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 100 3e-21
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 100 3e-21
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 100 3e-21
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 100 3e-21
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 100 3e-21
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 100 3e-21
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 99 7e-21
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 99 7e-21
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 96 5e-20
gi|42734375 ankyrin repeat and sterile alpha motif domain contai... 96 6e-20
>gi|148596917 fibronectin type III and ankyrin repeat domains 1
[Homo sapiens]
Length = 345
Score = 703 bits (1814), Expect = 0.0
Identities = 345/345 (100%), Positives = 345/345 (100%)
Query: 1 MEPQKIMPPSKPHPPVVGKVTHHSIELYWDLEKKAKRQGPQEQWFRFSIEEEDPKMHTYG 60
MEPQKIMPPSKPHPPVVGKVTHHSIELYWDLEKKAKRQGPQEQWFRFSIEEEDPKMHTYG
Sbjct: 1 MEPQKIMPPSKPHPPVVGKVTHHSIELYWDLEKKAKRQGPQEQWFRFSIEEEDPKMHTYG 60
Query: 61 IIYTGYATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSV 120
IIYTGYATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSV
Sbjct: 61 IIYTGYATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSV 120
Query: 121 NDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS 180
NDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS
Sbjct: 121 NDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS 180
Query: 181 LMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVD 240
LMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVD
Sbjct: 181 LMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVD 240
Query: 241 TGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDK 300
TGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDK
Sbjct: 241 TGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDK 300
Query: 301 GADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPKKSCVC 345
GADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPKKSCVC
Sbjct: 301 GADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPKKSCVC 345
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 114 bits (286), Expect = 1e-25
Identities = 67/188 (35%), Positives = 105/188 (55%), Gaps = 3/188 (1%)
Query: 137 VDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYL 196
V+V ++ G TAL AA G+ +V +L++ G ++N + + +L A Y GHLDVV L
Sbjct: 108 VNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 167
Query: 197 RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSG 256
HGA +D G T LH AA G +V++ ++ G E+D ++ + ++ +G
Sbjct: 168 INHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG--NTALHIACYNG 225
Query: 257 NQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL-VQLLLDKGADASVKNEFGKGVL 315
V + LID GANVN + NG TPL A + H L ++LL++ GAD +++++ GK L
Sbjct: 226 QDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPL 285
Query: 316 EMARVFDR 323
M V R
Sbjct: 286 HMTAVHGR 293
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/232 (29%), Positives = 113/232 (48%), Gaps = 8/232 (3%)
Query: 110 SSEHLHRAVSVNDED--LLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILV--S 165
+SE L RA + +++ L + L + +K G+ ++ AA G+ + +++L+ +
Sbjct: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
Query: 166 NGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSV 225
N +G+ K L LA Y GH ++ L + RD G TAL AA GH
Sbjct: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
Query: 226 IEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGAN---VNVKDRNGKTPL 282
+E +I G + V D + TPL S ++G+ LL++ N V+VKD G+TPL
Sbjct: 591 VEALINPGASIFVKDNVTKRTPL-HASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPL 649
Query: 283 MVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERK 334
M+AV H + V LLL+K A+ + G L + + V +L E++
Sbjct: 650 MLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
Score = 90.1 bits (222), Expect = 3e-18
Identities = 62/193 (32%), Positives = 102/193 (52%), Gaps = 4/193 (2%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + D++ ++ G +V +K G+T L AA G +VK L++ G +++
Sbjct: 152 LHWAAYMGHLDVVALLINHG-AEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEI 210
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSV-IEWMIKD 232
N G +L +ACY G VV L +GA+ + G T LH+AA H ++ +E ++ +
Sbjct: 211 NVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNN 270
Query: 233 GCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEE 292
G +V+ + + G +PL ++AV G + LI G ++ D++G TPL VA HE
Sbjct: 271 GADVN-IQSKDGKSPL-HMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHEL 328
Query: 293 LVQLLLDKGADAS 305
L+ L GAD +
Sbjct: 329 LINTLRTSGADTA 341
Score = 81.6 bits (200), Expect = 9e-16
Identities = 60/241 (24%), Positives = 105/241 (43%), Gaps = 11/241 (4%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + L + +L V++ +K G + L + A G + L+ NG +++
Sbjct: 251 LHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV 310
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ G L +A GH ++ LR GA + LH AA H ++ G
Sbjct: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG 370
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
E+D D + +A GN LL +GA+ + KD+ G+TPL A N H
Sbjct: 371 FEIDTPDKFG--RTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHC 428
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLE---------ERKKKQRPKKSCV 344
++ L+ GA+ + +++G+ L A D ++L ER ++ + K++ +
Sbjct: 429 IETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATL 488
Query: 345 C 345
C
Sbjct: 489 C 489
Score = 79.0 bits (193), Expect = 6e-15
Identities = 58/217 (26%), Positives = 101/217 (46%), Gaps = 3/217 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + D +++ ++ G +V+ + T L A V++L+ + DVN +
Sbjct: 20 LHVAAFLGDAEIIELLILSG-ARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNAR 78
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ + + L +A + + + +S D GG TALH AA GH ++ ++ G
Sbjct: 79 DKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKG 138
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
++ D + +A G+ V +LLI+ GA V KD+ G TPL A N +
Sbjct: 139 ANINAFDKKD--RRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINV 196
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
V+ LL+ G + N +G L +A + +VV+ L
Sbjct: 197 VKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNEL 233
Score = 77.0 bits (188), Expect = 2e-14
Identities = 51/169 (30%), Positives = 83/169 (49%), Gaps = 2/169 (1%)
Query: 162 ILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGG 221
+L+ DVN + + L +A + G ++++ L GA A+D T LH A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 222 HCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTP 281
++ +IK +V+ D W + V+A + + A ++I ++VNV DR G+T
Sbjct: 61 SEEAVQVLIKHSADVNARD--KNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTA 118
Query: 282 LMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
L A LN H E+V LLL KGA+ + ++ + L A VV+LL
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 167
Score = 73.9 bits (180), Expect = 2e-13
Identities = 60/209 (28%), Positives = 96/209 (45%), Gaps = 8/209 (3%)
Query: 127 VRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACY 186
V +L VD + G TAL G+ V++L+ + K+ G+ L A
Sbjct: 661 VSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAA 720
Query: 187 AGHLDVVKYLRRHGASWQA---RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGS 243
GH + L + S + +D G T LHWA G+ + IE +++ C + G+
Sbjct: 721 RGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFI--GN 778
Query: 244 GWTPLMRVSAVSGNQRVASLLIDA--GANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKG 301
+TPL + ++ + ASLL+ A + V+ +D G+TPL A +H E +QLLL
Sbjct: 779 PFTPL-HCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHS 837
Query: 302 ADASVKNEFGKGVLEMARVFDRQSVVSLL 330
A + + GK L MA + V +L
Sbjct: 838 APVNAVDNSGKTALMMAAENGQAGAVDIL 866
Score = 68.9 bits (167), Expect = 6e-12
Identities = 59/234 (25%), Positives = 99/234 (42%), Gaps = 31/234 (13%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A D ++L G ++D P+KFG T L AA G +K+L S+G D + K
Sbjct: 351 LHLAALNAHSDCCRKLLSSG-FEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAA-----------DGGH 222
+ G+ L A H ++ L GA+ D G TALH+AA H
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAH 469
Query: 223 CS-----------------VIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ +E+++++ + D G+ + +A Q + LL
Sbjct: 470 DNSEELERARELKEKEATLCLEFLLQNDANPSIRDK-EGYNSIHYAAAYGHRQCLELLLE 528
Query: 266 DAGANVNVKDRNG-KTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMA 318
+ D K+PL +A N H + +++LL D +++E G+ L++A
Sbjct: 529 RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLA 582
Score = 67.4 bits (163), Expect = 2e-11
Identities = 61/227 (26%), Positives = 97/227 (42%), Gaps = 43/227 (18%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTD---- 169
LH A + N + +L V +D+ ++ G TAL +AA KG+T V+ L++ G
Sbjct: 546 LHLA-AYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK 604
Query: 170 ---------------------------------VNLKNGSGKDSLMLACYAGHLDVVKYL 196
V++K+ G+ LMLA GH+D V L
Sbjct: 605 DNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLL 664
Query: 197 RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSG 256
A+ D+ GCTALH GH ++ +++ + D+ G TPL +A G
Sbjct: 665 LEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDS-RGRTPL-HYAAARG 722
Query: 257 NQRVASLLIDAGANVN---VKDRNGKTPLMVAVLNNHEELVQLLLDK 300
+ S L+ + KD G TPL A N +E +++LL++
Sbjct: 723 HATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769
Score = 60.1 bits (144), Expect = 3e-09
Identities = 62/234 (26%), Positives = 100/234 (42%), Gaps = 41/234 (17%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVS---NGTDV 170
LHR + E+ + +L+ V + + G T L AA +G+ + L+ + D
Sbjct: 682 LHRGIMTGHEECVQMLLEQ-EVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740
Query: 171 NLKNGSGKDSLMLACYAGHLDVVKYLRR----------------------HG-------- 200
K+ G L ACY G+ + ++ L HG
Sbjct: 741 CFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLG 800
Query: 201 ----ASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSG 256
+ RD G T L AA H ++ +++ V+ VD SG T LM ++A +G
Sbjct: 801 AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDN-SGKTALM-MAAENG 858
Query: 257 NQRVASLLID-AGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNE 309
+L++ A A++ VKD++ TPL +A HE+ L+LDK D S+ NE
Sbjct: 859 QAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINE 912
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 109 bits (272), Expect = 4e-24
Identities = 71/191 (37%), Positives = 99/191 (51%), Gaps = 2/191 (1%)
Query: 125 LLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLA 184
LL +L GRV VD + G T LMVAA G+ V+ LV G D+NL+ SG +L A
Sbjct: 27 LLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFA 86
Query: 185 CYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
GH DVV++L GAS + R G TAL A+ GH V+E ++K G + D
Sbjct: 87 AQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIH--DQLYD 144
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
+ ++A G V LL+ +GA VN ++G PL +A H E+V+++L +GAD
Sbjct: 145 GATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADR 204
Query: 305 SVKNEFGKGVL 315
G L
Sbjct: 205 DAARNDGTTAL 215
Score = 85.5 bits (210), Expect = 6e-17
Identities = 57/181 (31%), Positives = 95/181 (52%), Gaps = 3/181 (1%)
Query: 151 AAQKGYTRLVKILVSNG-TDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLG 209
AA++G L+K+L+++G DV+ ++ G LM+A YAGH+D V+ L GA +
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
Query: 210 GCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGA 269
G TAL +AA GH V+ ++ G + T G T L+ S G+ +V L+ GA
Sbjct: 79 GTTALFFAAQQGHNDVVRFLFGFGASTE-FRTKDGGTALLAASQY-GHMQVVETLLKHGA 136
Query: 270 NVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSL 329
N++ + +G T L +A + ++++LLL GA + + G L +A VV +
Sbjct: 137 NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRV 196
Query: 330 L 330
+
Sbjct: 197 M 197
Score = 80.5 bits (197), Expect = 2e-15
Identities = 50/157 (31%), Positives = 88/157 (56%), Gaps = 6/157 (3%)
Query: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASW 203
G TAL +AAQ GY ++++L+++G VN G L +A GH +VV+ + GA
Sbjct: 145 GATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADR 204
Query: 204 QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASL 263
A G TAL AA+ G+ VI+ ++K + ++ G T + + +SGN + +L
Sbjct: 205 DAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNG---TSALHAAVLSGNIKTVAL 261
Query: 264 LIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDK 300
L++AGA+ +++++ + P A L +E +++LL K
Sbjct: 262 LLEAGADPSLRNKANELP---AELTKNERILRLLRSK 295
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 107 bits (268), Expect = 1e-23
Identities = 70/190 (36%), Positives = 107/190 (56%), Gaps = 3/190 (1%)
Query: 137 VDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYL 196
V+V ++ G TAL AA G+ +VK+L+S G ++N + + ++ A Y GH++VVK L
Sbjct: 133 VNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL 192
Query: 197 RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSG 256
HGA +D T LH AA G SV+++++ G +++ G TPL V+ +G
Sbjct: 193 VSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPL-HVACYNG 250
Query: 257 NQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL-VQLLLDKGADASVKNEFGKGVL 315
V + LID GA VN K+ G TPL A + H L ++LL+ GAD ++K++ GK L
Sbjct: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
Query: 316 EMARVFDRQS 325
M + R S
Sbjct: 311 HMTALHGRFS 320
Score = 100 bits (250), Expect = 1e-21
Identities = 72/205 (35%), Positives = 108/205 (52%), Gaps = 3/205 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LHRAV+ E+ V++L V+ +K T L +AA + + LV ++VN+
Sbjct: 78 LHRAVASCSEEA-VQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVS 136
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ +G+ +L A ++GH ++VK L GA+ A D A+HWAA GH V++ ++ G
Sbjct: 137 DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHG 196
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
EV D S +TPL +A SG V L+D G ++N + G TPL VA N + +
Sbjct: 197 AEVTCKDKKS-YTPL-HAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVV 254
Query: 294 VQLLLDKGADASVKNEFGKGVLEMA 318
V L+D GA + KNE G L A
Sbjct: 255 VNELIDCGAIVNQKNEKGFTPLHFA 279
Score = 94.7 bits (234), Expect = 1e-19
Identities = 70/213 (32%), Positives = 107/213 (50%), Gaps = 10/213 (4%)
Query: 124 DLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLML 183
D + +L G VD +K+G TAL A G+ V L+ +G L++ G+ + L
Sbjct: 667 DCVYSLLNKG-ANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHL 725
Query: 184 ACYAGHLDVVKYLRRHGASWQAR----DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVV 239
+ GH+ V+ L + AS A D G TALHWA GH + +E +++ EV
Sbjct: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ--EVFQK 783
Query: 240 DTGSGWTPLMRVSAVSGNQRVASLLIDA-GAN-VNVKDRNGKTPLMVAVLNNHEELVQLL 297
G+ ++PL + ++ N+ A +LID GA+ VN D G+TPL A +H E +QLL
Sbjct: 784 TEGNAFSPL-HCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLL 842
Query: 298 LDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
L A + + GK L MA + + V +L
Sbjct: 843 LSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Score = 93.2 bits (230), Expect = 3e-19
Identities = 63/194 (32%), Positives = 102/194 (52%), Gaps = 3/194 (1%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
+V++L +V +K +T L AA G +VK L+ G D+N N G L +AC
Sbjct: 188 VVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC 247
Query: 186 YAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSV-IEWMIKDGCEVDVVDTGSG 244
Y G VV L GA ++ G T LH+AA H ++ +E ++ +G +V+ + + G
Sbjct: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN-MKSKDG 306
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
TPL ++A+ G + +I +GA ++ +D+NG TPL +A HE L+ L+ GAD
Sbjct: 307 KTPL-HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADT 365
Query: 305 SVKNEFGKGVLEMA 318
+ + G L +A
Sbjct: 366 AKRGIHGMFPLHLA 379
Score = 82.8 bits (203), Expect = 4e-16
Identities = 65/238 (27%), Positives = 111/238 (46%), Gaps = 16/238 (6%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVS-------- 165
LH A + + + + L + +K G+ A+ +A G+ ++++ S
Sbjct: 475 LHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLM 534
Query: 166 --NGTDV--NLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGG 221
+GTD+ + N + L LA Y GH ++ L + R+ G T L AA G
Sbjct: 535 ETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKG 594
Query: 222 HCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI---DAGANVNVKDRNG 278
H ++ +I G + V D TP+ +A +G+ LLI + V+++D NG
Sbjct: 595 HVECVDVLINQGASILVKDYILKRTPI-HAAATNGHSECLRLLIGNAEPQNAVDIQDGNG 653
Query: 279 KTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKK 336
+TPLM++VLN H + V LL+KGA+ K+++G+ L V + V L + K
Sbjct: 654 QTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 711
Score = 75.9 bits (185), Expect = 5e-14
Identities = 51/184 (27%), Positives = 87/184 (47%), Gaps = 2/184 (1%)
Query: 147 ALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQAR 206
+L+ A G V+ L+ DVN ++ + L A Y G ++++ L GA A+
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 207 DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLID 266
D T LH A ++ ++K +V+ D W + ++A + + A L+
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARD--KNWQTPLHIAAANKAVKCAEALVP 128
Query: 267 AGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSV 326
+NVNV DR G+T L A + H E+V+LLL +GA+ + ++ + + A V
Sbjct: 129 LLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEV 188
Query: 327 VSLL 330
V LL
Sbjct: 189 VKLL 192
Score = 75.5 bits (184), Expect = 7e-14
Identities = 55/209 (26%), Positives = 94/209 (44%), Gaps = 2/209 (0%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + L + +L G V++ +K G T L + A G + ++ +G ++ +
Sbjct: 276 LHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE 335
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ +G L +A GH ++ L GA R + G LH AA G ++ G
Sbjct: 336 DKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSG 395
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
++D D + +A GN +LL++ GA+ N KD+ G++PL A N + +
Sbjct: 396 FDIDTPDDFG--RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQC 453
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFD 322
+ L+ GA + +E G L A D
Sbjct: 454 LFALVGSGASVNDLDERGCTPLHYAATSD 482
Score = 73.9 bits (180), Expect = 2e-13
Identities = 56/203 (27%), Positives = 99/203 (48%), Gaps = 4/203 (1%)
Query: 129 ILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAG 188
I+Q G V +D +K G T L +AA+ G+ L+ L+++G D + G L LA +G
Sbjct: 325 IIQSGAV-IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383
Query: 189 HLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPL 248
D + L G D G T LH AA GG+ + ++ G + + D G +PL
Sbjct: 384 FSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDK-FGRSPL 442
Query: 249 MRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHE-ELVQLLLDKGADASVK 307
+A + N + L+ +GA+VN D G TPL A ++ + + ++ LL A+ ++
Sbjct: 443 -HYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIR 501
Query: 308 NEFGKGVLEMARVFDRQSVVSLL 330
++ G + + + + + L+
Sbjct: 502 DKQGYNAVHYSAAYGHRLCLQLI 524
Score = 68.6 bits (166), Expect = 8e-12
Identities = 56/185 (30%), Positives = 86/185 (46%), Gaps = 2/185 (1%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
T L AA G ++++L+ +G VN K+ L A + + V+ L +H A A
Sbjct: 43 TPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNA 102
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
RD T LH AA E ++ V+V D +G T L +A SG+ + LL+
Sbjct: 103 RDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDR-AGRTALHH-AAFSGHGEMVKLLL 160
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQS 325
GAN+N D+ + + A H E+V+LL+ GA+ + K++ L A S
Sbjct: 161 SRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMIS 220
Query: 326 VVSLL 330
VV L
Sbjct: 221 VVKYL 225
Score = 57.4 bits (137), Expect = 2e-08
Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 4/155 (2%)
Query: 180 SLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVV 239
SL+ A + G D V+ L +D T LH AA G +IE +I G V+
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 240 DTGSGW-TPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLL 298
D S W TPL R A S ++ +L+ A+VN +D+N +TPL +A N + + L+
Sbjct: 71 D--SKWLTPLHRAVA-SCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
Query: 299 DKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
++ +V + G+ L A +V LL R
Sbjct: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 162
Score = 54.7 bits (130), Expect = 1e-07
Identities = 50/179 (27%), Positives = 83/179 (46%), Gaps = 5/179 (2%)
Query: 114 LHRAVSVNDEDLLVRILQG--GRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVN 171
LH AV +ND + +L G V+ + G T L AA + +++L+S+ VN
Sbjct: 792 LHCAV-INDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850
Query: 172 LKNGSGKDSLMLACYAGHLDVVKYL-RRHGASWQARDLGGCTALHWAADGGHCSVIEWMI 230
+ +GK LM+A G + V+ L A +D TALH A GH + ++
Sbjct: 851 SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLIL 910
Query: 231 KDGCEVDVVD-TGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 288
+ + ++++ T + + V+A +G V L+ GA+V D NG TP + N
Sbjct: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPN 969
Score = 51.6 bits (122), Expect = 1e-06
Identities = 39/145 (26%), Positives = 66/145 (45%), Gaps = 4/145 (2%)
Query: 170 VNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWM 229
VN + G+ L A + H++ ++ L H A + D G T L AA+ G + +E +
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Query: 230 IKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGAN---VNVKDRNGKTPLMVAV 286
+ + S T L ++ G++ A L+++ + +N + +TPL VA
Sbjct: 876 VSSASAELTLQDNSKNTAL-HLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAA 934
Query: 287 LNNHEELVQLLLDKGADASVKNEFG 311
N +VQ LL KGA +E G
Sbjct: 935 RNGLTMVVQELLGKGASVLAVDENG 959
Score = 29.6 bits (65), Expect = 4.1
Identities = 17/62 (27%), Positives = 30/62 (48%)
Query: 247 PLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV 306
P + + +G+ LI +VN +D +TPL A E+++LL+ GA +
Sbjct: 10 PSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA 69
Query: 307 KN 308
K+
Sbjct: 70 KD 71
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 107 bits (267), Expect = 2e-23
Identities = 73/229 (31%), Positives = 126/229 (55%), Gaps = 7/229 (3%)
Query: 87 VTSPSGECEYSPLVSVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFT 146
+ SPS P + + E L A + E+L+ +L+ G ++ +K GFT
Sbjct: 1060 IISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERG-ASIEHRDKKGFT 1118
Query: 147 ALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LMLACYAGHLDVVKYLRRHGASWQA 205
L++AA G+ +V+IL+ NG D+ ++ KD+ L LAC G +VV+ L GA+ +
Sbjct: 1119 PLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEH 1178
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGS--GWTPLMRVSAVSGNQRVASL 263
R++ T L AA GG+ ++I+ ++ G E++ TGS G +PLM ++A++G+ L
Sbjct: 1179 RNVSDYTPLSLAASGGYVNIIKILLNAGAEIN-SRTGSKLGISPLM-LAAMNGHTAAVKL 1236
Query: 264 LIDAGANVNVK-DRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFG 311
L+D G+++N + + N T L +A E+V LLLD+ A+ + + G
Sbjct: 1237 LLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1285
Score = 100 bits (250), Expect = 1e-21
Identities = 59/181 (32%), Positives = 100/181 (55%), Gaps = 3/181 (1%)
Query: 126 LVRIL--QGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LM 182
+++IL G + +K G + LM+AA G+T VK+L+ G+D+N + + +++ L
Sbjct: 1198 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALT 1257
Query: 183 LACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTG 242
LAC+ G +VV L A+ + R G T L AA GG+ V ++ G +V+
Sbjct: 1258 LACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1317
Query: 243 SGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGA 302
S + ++A G+ + LLI GA+++V+++ G TPL +A H ++VQLL+ GA
Sbjct: 1318 SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1377
Query: 303 D 303
D
Sbjct: 1378 D 1378
Score = 94.4 bits (233), Expect = 1e-19
Identities = 58/192 (30%), Positives = 99/192 (51%), Gaps = 1/192 (0%)
Query: 142 KFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGA 201
K T LM AA G+ ++VK+L+++ DVN ++ +G +L AC G++DVVK L GA
Sbjct: 299 KGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGA 358
Query: 202 SWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVA 261
S + + G T L A GH V ++++G ++ + + ++ G+ +
Sbjct: 359 SIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGHLEMV 417
Query: 262 SLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVF 321
L++AGA+ K T LM A ++ H E+ +LLLD GA ++ + + L +A
Sbjct: 418 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 477
Query: 322 DRQSVVSLLEER 333
+ +LL ER
Sbjct: 478 GHVELAALLIER 489
Score = 91.7 bits (226), Expect = 9e-19
Identities = 63/218 (28%), Positives = 105/218 (48%), Gaps = 36/218 (16%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVN-------------- 171
+V++L + V+ + G TAL A GY +VK+L+ +G +
Sbjct: 316 IVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAG 375
Query: 172 -----------LKNGSG---------KDSLMLACYAGHLDVVKYLRRHGASWQARDLGGC 211
L+NG+G + +L LACY GHL++V++L GA + +
Sbjct: 376 SAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMH 435
Query: 212 TALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANV 271
TAL A GH V ++ G +V++ + + ++A G+ +A+LLI+ GA++
Sbjct: 436 TALMEACMDGHVEVARLLLDSGAQVNM--PADSFESPLTLAACGGHVELAALLIERGASL 493
Query: 272 NVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNE 309
+ G TPLM A HEE+V LLL +GA+ + + E
Sbjct: 494 EEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTE 531
Score = 91.3 bits (225), Expect = 1e-18
Identities = 66/193 (34%), Positives = 105/193 (54%), Gaps = 6/193 (3%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
TAL +A G+ LV+ L+ G + ++ G L+LA AGH+ VV+ L +GA +A
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 206 R-DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLL 264
+ + T L A GG V+E ++ G + + S +TPL ++A G + +L
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV-SDYTPL-SLAASGGYVNIIKIL 1202
Query: 265 IDAGANVNVK--DRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKG-VLEMARVF 321
++AGA +N + + G +PLM+A +N H V+LLLD G+D + + E + L +A
Sbjct: 1203 LNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQ 1262
Query: 322 DRQSVVSLLEERK 334
R VVSLL +RK
Sbjct: 1263 GRTEVVSLLLDRK 1275
Score = 87.0 bits (214), Expect = 2e-17
Identities = 56/166 (33%), Positives = 92/166 (55%), Gaps = 6/166 (3%)
Query: 141 NKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LMLACYAGHLDVVKYLRRH 199
N G+T LM AA++G+ +V +L+ G ++N + +++ L LAC G L+V +L +
Sbjct: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556
Query: 200 GASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQR 259
GA + LG T L AA GH ++++++ G V T +G T L + +G+
Sbjct: 557 GADIE---LGCSTPLMEAAQEGHLELVKYLLAAGANVHAT-TATGDTALT-YACENGHTD 611
Query: 260 VASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADAS 305
VA +L+ AGA++ + G+TPLM A H VQ L+ KGA+ +
Sbjct: 612 VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
Score = 85.5 bits (210), Expect = 6e-17
Identities = 78/260 (30%), Positives = 121/260 (46%), Gaps = 12/260 (4%)
Query: 77 PRTLYRFRLKVTSPSGECEYSPL-VSVSTTREPISSEH---LHRAVSVNDEDLLVRIL-Q 131
P + L + + G E + L + + E ++ E L A E+++ +L Q
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 132 GGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLD 191
G + + TAL +A G+ + L+ G D+ L + LM A GHL+
Sbjct: 523 GANINAQT-EETQETALTLACCGGFLEVADFLIKAGADIELGCST---PLMEAAQEGHLE 578
Query: 192 VVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRV 251
+VKYL GA+ A G TAL +A + GH V + +++ G +++ G G TPLM+
Sbjct: 579 LVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG-GRTPLMK- 636
Query: 252 SAVSGNQRVASLLIDAGANVN-VKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEF 310
+A +G+ LI GANVN N T L +A H +V+LLL GAD + + +
Sbjct: 637 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD 696
Query: 311 GKGVLEMARVFDRQSVVSLL 330
G +L A SVV L
Sbjct: 697 GSTMLIEAAKGGHTSVVCYL 716
Score = 82.4 bits (202), Expect = 5e-16
Identities = 51/154 (33%), Positives = 79/154 (51%), Gaps = 1/154 (0%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
T LM AAQ+G+ LVK L++ G +V+ +G +L AC GH DV L + GA +
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
GG T L AA GH ++++I G V+ + T ++ ++ G+ V LL+
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT-VLSLACAGGHLAVVELLL 684
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLD 299
GA+ + ++G T L+ A H +V LLD
Sbjct: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 79.0 bits (193), Expect = 6e-15
Identities = 60/196 (30%), Positives = 96/196 (48%), Gaps = 4/196 (2%)
Query: 147 ALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQAR 206
+L A +G V+ L+ G VN G+ L LAC AG+ ++ + L A+ + R
Sbjct: 237 SLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 296
Query: 207 DL-GGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ G T L AA+GGH +++ ++ +V+ + +G T L A G V +L+
Sbjct: 297 GIKGDITPLMAAANGGHVKIVKLLLAHKADVN-AQSSTGNTALTYACA-GGYVDVVKVLL 354
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV-KNEFGKGVLEMARVFDRQ 324
++GA++ + NG TPLM A H E+ +LLL+ GA + NEF + L +A
Sbjct: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414
Query: 325 SVVSLLEERKKKQRPK 340
+V L E Q K
Sbjct: 415 EMVRFLLEAGADQEHK 430
Score = 79.0 bits (193), Expect = 6e-15
Identities = 60/194 (30%), Positives = 95/194 (48%), Gaps = 6/194 (3%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
+ R+L +V++P + L +AA G+ L +L+ G + N G LM A
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
Query: 186 YAGHLDVVKYLRRHGASWQAR-DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
GH ++V L GA+ A+ + TAL A GG V +++IK G ++++ +
Sbjct: 509 REGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS--- 565
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
TPLM +A G+ + L+ AGANV+ G T L A N H ++ +LL GAD
Sbjct: 566 -TPLME-AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 623
Query: 305 SVKNEFGKGVLEMA 318
++E G+ L A
Sbjct: 624 EHESEGGRTPLMKA 637
Score = 74.3 bits (181), Expect = 1e-13
Identities = 53/173 (30%), Positives = 80/173 (46%), Gaps = 4/173 (2%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
TALM A G+ + ++L+ +G VN+ S + L LA GH+++ L GAS +
Sbjct: 436 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEE 495
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ G T L AA GH ++ ++ G ++ T + ++ G VA LI
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANIN-AQTEETQETALTLACCGGFLEVADFLI 554
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMA 318
AGA++ + TPLM A H ELV+ LL GA+ G L A
Sbjct: 555 KAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604
Score = 62.8 bits (151), Expect = 4e-10
Identities = 51/196 (26%), Positives = 87/196 (44%), Gaps = 26/196 (13%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
TAL +AA KG+ + ++L+ G ++++N G L LA GHLDVV+ L + GA A
Sbjct: 1322 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1381
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
D T L A GH V+ +++K +V S + ++ ++ + + +
Sbjct: 1382 ADNRKITPLMAAFRKGHVKVVRYLVK-----EVNQFPSDSECMRYIATITDKEMLKKCHL 1436
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQS 325
+ V KDR A N + ++ LD LE R R+
Sbjct: 1437 CMESIVQAKDR------QAAEANKNASILLEELD---------------LEKLREESRRL 1475
Query: 326 VVSLLEERKKKQRPKK 341
++ E++K++R KK
Sbjct: 1476 ALAAKREKRKEKRRKK 1491
Score = 55.5 bits (132), Expect = 7e-08
Identities = 41/147 (27%), Positives = 66/147 (44%), Gaps = 3/147 (2%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
LV+ L V G TAL A + G+T + +L+ G D+ ++ G+ LM A
Sbjct: 579 LVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 638
Query: 186 YAGHLDVVKYLRRHGASWQARDLGG-CTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
AGH+ V++L GA+ T L A GGH +V+E ++ G D
Sbjct: 639 RAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG--ADPTHRLKD 696
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANV 271
+ ++ +A G+ V L+D N+
Sbjct: 697 GSTMLIEAAKGGHTSVVCYLLDYPNNL 723
Score = 46.6 bits (109), Expect = 3e-05
Identities = 27/68 (39%), Positives = 38/68 (55%)
Query: 129 ILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAG 188
+L G +DV NK G T L +AA G+ +V++LV G DV+ + LM A G
Sbjct: 1338 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKG 1397
Query: 189 HLDVVKYL 196
H+ VV+YL
Sbjct: 1398 HVKVVRYL 1405
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 107 bits (267), Expect = 2e-23
Identities = 73/229 (31%), Positives = 126/229 (55%), Gaps = 7/229 (3%)
Query: 87 VTSPSGECEYSPLVSVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFT 146
+ SPS P + + E L A + E+L+ +L+ G ++ +K GFT
Sbjct: 809 IISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERG-ASIEHRDKKGFT 867
Query: 147 ALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LMLACYAGHLDVVKYLRRHGASWQA 205
L++AA G+ +V+IL+ NG D+ ++ KD+ L LAC G +VV+ L GA+ +
Sbjct: 868 PLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEH 927
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGS--GWTPLMRVSAVSGNQRVASL 263
R++ T L AA GG+ ++I+ ++ G E++ TGS G +PLM ++A++G+ L
Sbjct: 928 RNVSDYTPLSLAASGGYVNIIKILLNAGAEIN-SRTGSKLGISPLM-LAAMNGHTAAVKL 985
Query: 264 LIDAGANVNVK-DRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFG 311
L+D G+++N + + N T L +A E+V LLLD+ A+ + + G
Sbjct: 986 LLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1034
Score = 100 bits (250), Expect = 1e-21
Identities = 59/181 (32%), Positives = 100/181 (55%), Gaps = 3/181 (1%)
Query: 126 LVRIL--QGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LM 182
+++IL G + +K G + LM+AA G+T VK+L+ G+D+N + + +++ L
Sbjct: 947 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALT 1006
Query: 183 LACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTG 242
LAC+ G +VV L A+ + R G T L AA GG+ V ++ G +V+
Sbjct: 1007 LACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1066
Query: 243 SGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGA 302
S + ++A G+ + LLI GA+++V+++ G TPL +A H ++VQLL+ GA
Sbjct: 1067 SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1126
Query: 303 D 303
D
Sbjct: 1127 D 1127
Score = 94.4 bits (233), Expect = 1e-19
Identities = 58/192 (30%), Positives = 99/192 (51%), Gaps = 1/192 (0%)
Query: 142 KFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGA 201
K T LM AA G+ ++VK+L+++ DVN ++ +G +L AC G++DVVK L GA
Sbjct: 299 KGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGA 358
Query: 202 SWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVA 261
S + + G T L A GH V ++++G ++ + + ++ G+ +
Sbjct: 359 SIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGHLEMV 417
Query: 262 SLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVF 321
L++AGA+ K T LM A ++ H E+ +LLLD GA ++ + + L +A
Sbjct: 418 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 477
Query: 322 DRQSVVSLLEER 333
+ +LL ER
Sbjct: 478 GHVELAALLIER 489
Score = 91.7 bits (226), Expect = 9e-19
Identities = 63/218 (28%), Positives = 105/218 (48%), Gaps = 36/218 (16%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVN-------------- 171
+V++L + V+ + G TAL A GY +VK+L+ +G +
Sbjct: 316 IVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAG 375
Query: 172 -----------LKNGSG---------KDSLMLACYAGHLDVVKYLRRHGASWQARDLGGC 211
L+NG+G + +L LACY GHL++V++L GA + +
Sbjct: 376 SAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMH 435
Query: 212 TALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANV 271
TAL A GH V ++ G +V++ + + ++A G+ +A+LLI+ GA++
Sbjct: 436 TALMEACMDGHVEVARLLLDSGAQVNM--PADSFESPLTLAACGGHVELAALLIERGASL 493
Query: 272 NVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNE 309
+ G TPLM A HEE+V LLL +GA+ + + E
Sbjct: 494 EEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTE 531
Score = 91.3 bits (225), Expect = 1e-18
Identities = 66/193 (34%), Positives = 105/193 (54%), Gaps = 6/193 (3%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
TAL +A G+ LV+ L+ G + ++ G L+LA AGH+ VV+ L +GA +A
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Query: 206 R-DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLL 264
+ + T L A GG V+E ++ G + + S +TPL ++A G + +L
Sbjct: 894 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV-SDYTPL-SLAASGGYVNIIKIL 951
Query: 265 IDAGANVNVK--DRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKG-VLEMARVF 321
++AGA +N + + G +PLM+A +N H V+LLLD G+D + + E + L +A
Sbjct: 952 LNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQ 1011
Query: 322 DRQSVVSLLEERK 334
R VVSLL +RK
Sbjct: 1012 GRTEVVSLLLDRK 1024
Score = 87.0 bits (214), Expect = 2e-17
Identities = 56/166 (33%), Positives = 92/166 (55%), Gaps = 6/166 (3%)
Query: 141 NKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LMLACYAGHLDVVKYLRRH 199
N G+T LM AA++G+ +V +L+ G ++N + +++ L LAC G L+V +L +
Sbjct: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556
Query: 200 GASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQR 259
GA + LG T L AA GH ++++++ G V T +G T L + +G+
Sbjct: 557 GADIE---LGCSTPLMEAAQEGHLELVKYLLAAGANVHAT-TATGDTALT-YACENGHTD 611
Query: 260 VASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADAS 305
VA +L+ AGA++ + G+TPLM A H VQ L+ KGA+ +
Sbjct: 612 VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
Score = 85.5 bits (210), Expect = 6e-17
Identities = 78/260 (30%), Positives = 121/260 (46%), Gaps = 12/260 (4%)
Query: 77 PRTLYRFRLKVTSPSGECEYSPL-VSVSTTREPISSEH---LHRAVSVNDEDLLVRIL-Q 131
P + L + + G E + L + + E ++ E L A E+++ +L Q
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 132 GGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLD 191
G + + TAL +A G+ + L+ G D+ L + LM A GHL+
Sbjct: 523 GANINAQT-EETQETALTLACCGGFLEVADFLIKAGADIELGCST---PLMEAAQEGHLE 578
Query: 192 VVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRV 251
+VKYL GA+ A G TAL +A + GH V + +++ G +++ G G TPLM+
Sbjct: 579 LVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG-GRTPLMK- 636
Query: 252 SAVSGNQRVASLLIDAGANVN-VKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEF 310
+A +G+ LI GANVN N T L +A H +V+LLL GAD + + +
Sbjct: 637 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD 696
Query: 311 GKGVLEMARVFDRQSVVSLL 330
G +L A SVV L
Sbjct: 697 GSTMLIEAAKGGHTSVVCYL 716
Score = 82.4 bits (202), Expect = 5e-16
Identities = 51/154 (33%), Positives = 79/154 (51%), Gaps = 1/154 (0%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
T LM AAQ+G+ LVK L++ G +V+ +G +L AC GH DV L + GA +
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
GG T L AA GH ++++I G V+ + T ++ ++ G+ V LL+
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT-VLSLACAGGHLAVVELLL 684
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLD 299
GA+ + ++G T L+ A H +V LLD
Sbjct: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 79.0 bits (193), Expect = 6e-15
Identities = 60/196 (30%), Positives = 96/196 (48%), Gaps = 4/196 (2%)
Query: 147 ALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQAR 206
+L A +G V+ L+ G VN G+ L LAC AG+ ++ + L A+ + R
Sbjct: 237 SLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 296
Query: 207 DL-GGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ G T L AA+GGH +++ ++ +V+ + +G T L A G V +L+
Sbjct: 297 GIKGDITPLMAAANGGHVKIVKLLLAHKADVN-AQSSTGNTALTYACA-GGYVDVVKVLL 354
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV-KNEFGKGVLEMARVFDRQ 324
++GA++ + NG TPLM A H E+ +LLL+ GA + NEF + L +A
Sbjct: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414
Query: 325 SVVSLLEERKKKQRPK 340
+V L E Q K
Sbjct: 415 EMVRFLLEAGADQEHK 430
Score = 79.0 bits (193), Expect = 6e-15
Identities = 60/194 (30%), Positives = 95/194 (48%), Gaps = 6/194 (3%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
+ R+L +V++P + L +AA G+ L +L+ G + N G LM A
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
Query: 186 YAGHLDVVKYLRRHGASWQAR-DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
GH ++V L GA+ A+ + TAL A GG V +++IK G ++++ +
Sbjct: 509 REGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS--- 565
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
TPLM +A G+ + L+ AGANV+ G T L A N H ++ +LL GAD
Sbjct: 566 -TPLME-AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 623
Query: 305 SVKNEFGKGVLEMA 318
++E G+ L A
Sbjct: 624 EHESEGGRTPLMKA 637
Score = 74.3 bits (181), Expect = 1e-13
Identities = 53/173 (30%), Positives = 80/173 (46%), Gaps = 4/173 (2%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
TALM A G+ + ++L+ +G VN+ S + L LA GH+++ L GAS +
Sbjct: 436 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEE 495
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ G T L AA GH ++ ++ G ++ T + ++ G VA LI
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANIN-AQTEETQETALTLACCGGFLEVADFLI 554
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMA 318
AGA++ + TPLM A H ELV+ LL GA+ G L A
Sbjct: 555 KAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604
Score = 62.8 bits (151), Expect = 4e-10
Identities = 51/196 (26%), Positives = 87/196 (44%), Gaps = 26/196 (13%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
TAL +AA KG+ + ++L+ G ++++N G L LA GHLDVV+ L + GA A
Sbjct: 1071 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1130
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
D T L A GH V+ +++K +V S + ++ ++ + + +
Sbjct: 1131 ADNRKITPLMAAFRKGHVKVVRYLVK-----EVNQFPSDSECMRYIATITDKEMLKKCHL 1185
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQS 325
+ V KDR A N + ++ LD LE R R+
Sbjct: 1186 CMESIVQAKDR------QAAEANKNASILLEELD---------------LEKLREESRRL 1224
Query: 326 VVSLLEERKKKQRPKK 341
++ E++K++R KK
Sbjct: 1225 ALAAKREKRKEKRRKK 1240
Score = 55.5 bits (132), Expect = 7e-08
Identities = 41/147 (27%), Positives = 66/147 (44%), Gaps = 3/147 (2%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
LV+ L V G TAL A + G+T + +L+ G D+ ++ G+ LM A
Sbjct: 579 LVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 638
Query: 186 YAGHLDVVKYLRRHGASWQARDLGG-CTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
AGH+ V++L GA+ T L A GGH +V+E ++ G D
Sbjct: 639 RAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG--ADPTHRLKD 696
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANV 271
+ ++ +A G+ V L+D N+
Sbjct: 697 GSTMLIEAAKGGHTSVVCYLLDYPNNL 723
Score = 46.6 bits (109), Expect = 3e-05
Identities = 27/68 (39%), Positives = 38/68 (55%)
Query: 129 ILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAG 188
+L G +DV NK G T L +AA G+ +V++LV G DV+ + LM A G
Sbjct: 1087 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKG 1146
Query: 189 HLDVVKYL 196
H+ VV+YL
Sbjct: 1147 HVKVVRYL 1154
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 106 bits (265), Expect = 3e-23
Identities = 64/206 (31%), Positives = 110/206 (53%), Gaps = 2/206 (0%)
Query: 127 VRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACY 186
V+IL + +D G AL VAA +G+ +V++L S+G DVN K+ G+ +L +
Sbjct: 896 VQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILAL 955
Query: 187 AGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWT 246
L + +Y +GA+ +A D G TALH + GH +++ +I +V+ D
Sbjct: 956 ENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEK--R 1013
Query: 247 PLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV 306
++ +A G+ +V LLI+ GA V+ G T L +A H ++VQ+LL+ GAD +
Sbjct: 1014 SALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNH 1073
Query: 307 KNEFGKGVLEMARVFDRQSVVSLLEE 332
++FG+ + +A ++ LLE+
Sbjct: 1074 ADQFGRTAMRVAAKNGHSQIIKLLEK 1099
Score = 103 bits (257), Expect = 2e-22
Identities = 75/216 (34%), Positives = 108/216 (50%), Gaps = 8/216 (3%)
Query: 123 EDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLM 182
ED + +L G V+ + G T L AA G +V +LVS G D+ +++ G L
Sbjct: 525 EDSIRTLLDNG-ASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLT 583
Query: 183 LACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTG 242
LA GH VV L GA+ D G TAL AA GGH V+ ++ G +VD D
Sbjct: 584 LAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD 643
Query: 243 SGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGA 302
S +R +A G++ + L+ GA VN D G+T L+ A H E+V+ LLD GA
Sbjct: 644 S--RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGA 701
Query: 303 DASVKNEFGKGVLEMARVF-----DRQSVVSLLEER 333
+ + ++ G+ L +A + SVVSLL +R
Sbjct: 702 EVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR 737
Score = 98.2 bits (243), Expect = 9e-21
Identities = 73/252 (28%), Positives = 112/252 (44%), Gaps = 46/252 (18%)
Query: 112 EHL-HRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDV 170
EHL VN ED+ GR + V AL V A KG+ +V +L+ G +V
Sbjct: 694 EHLLDHGAEVNHEDV------DGRTALSV------AALCVPASKGHASVVSLLIDRGAEV 741
Query: 171 NLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMI 230
+ + G L++A Y GH+DVV L GA D G T L AA GH SV+ ++
Sbjct: 742 DHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLL 801
Query: 231 KDGCEVDVVDT--------------------------------GSGWTPLMRVSAVSGNQ 258
G VD +D+ +GWTPL ++A G++
Sbjct: 802 FWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPL-HMAAFEGHR 860
Query: 259 RVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMA 318
+ LI+ GA N D +G+ P ++A H + VQ+LL+ ++ + G+ L +A
Sbjct: 861 LICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVA 920
Query: 319 RVFDRQSVVSLL 330
+ + +V LL
Sbjct: 921 ALEGHRDIVELL 932
Score = 97.1 bits (240), Expect = 2e-20
Identities = 70/216 (32%), Positives = 115/216 (53%), Gaps = 8/216 (3%)
Query: 123 EDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLM 182
ED+++ +LQ G +V+ + G TAL+ AA G+ +V+ L+ +G +VN ++ G+ +L
Sbjct: 657 EDIVLNLLQHG-AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALS 715
Query: 183 LACYA-----GHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVD 237
+A GH VV L GA D G T L AA GH V++ +++ G +VD
Sbjct: 716 VAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD 775
Query: 238 VVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLL 297
D +G TPL+ +A G+ V + L+ GA V+ D G+T L +A + E+V+ L
Sbjct: 776 HTD-NNGRTPLL-AAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
Query: 298 LDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
LD+G D + +++ G L MA + + L E+
Sbjct: 834 LDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869
Score = 84.3 bits (207), Expect = 1e-16
Identities = 55/189 (29%), Positives = 89/189 (47%), Gaps = 2/189 (1%)
Query: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASW 203
G+T L +AA +G+ + + L+ G N + G+ +LA GH D V+ L + ++
Sbjct: 847 GWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNI 906
Query: 204 QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASL 263
R G AL AA GH ++E + G +V+ D P + + A+ +A
Sbjct: 907 DQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADG--RPTLYILALENQLTMAEY 964
Query: 264 LIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDR 323
++ GANV D G+T L V+ H E+VQ+L+ AD + + + L+ A
Sbjct: 965 FLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGH 1024
Query: 324 QSVVSLLEE 332
VV LL E
Sbjct: 1025 VKVVQLLIE 1033
Score = 79.3 bits (194), Expect = 5e-15
Identities = 48/182 (26%), Positives = 88/182 (48%), Gaps = 2/182 (1%)
Query: 137 VDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYL 196
VD + G T L +A+ +G +V+ L+ G D N ++ +G L +A + GH + + L
Sbjct: 807 VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866
Query: 197 RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSG 256
GA D G A+ GH ++ ++++ +D G +RV+A+ G
Sbjct: 867 IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNID--QRGYDGRNALRVAALEG 924
Query: 257 NQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLE 316
++ + LL GA+VN KD +G+ L + L N + + L+ GA+ + G+ L
Sbjct: 925 HRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALH 984
Query: 317 MA 318
++
Sbjct: 985 VS 986
Score = 60.5 bits (145), Expect = 2e-09
Identities = 35/108 (32%), Positives = 58/108 (53%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
+V++L V+ + +AL AA +G+ ++V++L+ +G V+ G +L +A
Sbjct: 994 MVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAA 1053
Query: 186 YAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
GH+DVV+ L HGA D G TA+ AA GH +I+ + K G
Sbjct: 1054 QEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101
Score = 51.6 bits (122), Expect = 1e-06
Identities = 29/84 (34%), Positives = 50/84 (59%), Gaps = 5/84 (5%)
Query: 129 ILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAG 188
+++ G V VD G TAL +AAQ+G+ +V++L+ +G D N + G+ ++ +A G
Sbjct: 1031 LIEHGAV-VDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNG 1089
Query: 189 HLDVVKYLRRHGASWQARDLGGCT 212
H ++K L ++GAS L GC+
Sbjct: 1090 HSQIIKLLEKYGAS----SLNGCS 1109
Score = 38.5 bits (88), Expect = 0.009
Identities = 33/107 (30%), Positives = 49/107 (45%), Gaps = 14/107 (13%)
Query: 228 WMIKDGCEV-DVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAV 286
WMI +G V D + T + Q V LL+ AGA+VN +D +T +V
Sbjct: 474 WMIWNGTPVRDSLST-----------LIPKEQEVLQLLVKAGAHVNSED--DRTSCIVRQ 520
Query: 287 LNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
E+ ++ LLD GA + + G+ +L A VV+LL R
Sbjct: 521 ALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSR 567
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 106 bits (264), Expect = 3e-23
Identities = 75/209 (35%), Positives = 108/209 (51%), Gaps = 13/209 (6%)
Query: 121 NDEDLLVRILQG--GRV------KVDVPNKF---GFTALMVAAQKGYTRLVKILVSNGTD 169
+D+ LL + +G GRV K P K G + +AA KG T + IL++NG D
Sbjct: 20 HDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGAD 79
Query: 170 VNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWM 229
+N KN G +L LA + VK L +HGA+ A D + LHWAA G S + +
Sbjct: 80 INSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLL 139
Query: 230 IKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNN 289
+DV+D G TPLM ++++ G+ + S L+ GA VNV D+N K+ L++A
Sbjct: 140 CDHEAFLDVLD-NDGRTPLM-IASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKG 197
Query: 290 HEELVQLLLDKGADASVKNEFGKGVLEMA 318
E+ +LLL GADA + G L A
Sbjct: 198 SAEVAELLLSHGADAGAVDSTGHDALHYA 226
Score = 39.7 bits (91), Expect = 0.004
Identities = 44/205 (21%), Positives = 79/205 (38%), Gaps = 37/205 (18%)
Query: 161 KILVSNGTDVNLKNGSGKDSLML-ACYAGHLDVVKYLR-RHGASWQARDLGGCTALHWAA 218
+I + T V ++ + D +L A + G + V L R A D G + H AA
Sbjct: 3 RIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAA 62
Query: 219 DGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGAN-------- 270
G + ++ +G +++ + + ++ +S + +L+ GAN
Sbjct: 63 SKGLTECLTILLANGADIN--SKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAEN 120
Query: 271 -------------------------VNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADAS 305
++V D +G+TPLM+A L H + LL +GA +
Sbjct: 121 RSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVN 180
Query: 306 VKNEFGKGVLEMARVFDRQSVVSLL 330
V ++ K L +A V LL
Sbjct: 181 VTDKNDKSALILACEKGSAEVAELL 205
Score = 36.6 bits (83), Expect = 0.034
Identities = 20/71 (28%), Positives = 43/71 (60%), Gaps = 1/71 (1%)
Query: 128 RILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYA 187
++LQ G +V+V +K +AL++A +KG + ++L+S+G D + +G D+L A +
Sbjct: 171 QLLQRG-ARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHT 229
Query: 188 GHLDVVKYLRR 198
+ ++L++
Sbjct: 230 QDKALWRHLQQ 240
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 105 bits (263), Expect = 5e-23
Identities = 68/219 (31%), Positives = 108/219 (49%), Gaps = 33/219 (15%)
Query: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASW 203
GFT L +A +K +++++L+ +G + SG + +A + GH+++V L HGAS
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459
Query: 204 QARDLGGCTALHWAADGGHCSVIEWMIKDGCEV--------------------DVVD--- 240
++ G TALH AA G V+ ++++DG +V D+V
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519
Query: 241 ---------TGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHE 291
T SG+TPL +SA G++ VA+ L+D GA++++ + G TPL VA
Sbjct: 520 QQGASPNAATTSGYTPL-HLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKL 578
Query: 292 ELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
E+ LLL K A + G L +A +D Q V LL
Sbjct: 579 EVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Score = 101 bits (252), Expect = 9e-22
Identities = 78/248 (31%), Positives = 117/248 (47%), Gaps = 30/248 (12%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A +++ +LQ VD K G TAL +A+ G +VK+LV+NG +VN +
Sbjct: 78 LHLASKEGHVEVVSELLQR-EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ +G L +A HL+VVK+L +GAS G T L A GH V+ ++++
Sbjct: 137 SQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEND 196
Query: 234 CEVDV----------------------------VDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ V V++ SG+TPL ++A GN VA+LL+
Sbjct: 197 TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPL-HIAAHYGNINVATLLL 255
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQS 325
+ A V+ RN TPL VA + +V+LLLD+GA K G L +
Sbjct: 256 NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQ 315
Query: 326 VVSLLEER 333
VV +L +R
Sbjct: 316 VVEMLLDR 323
Score = 96.3 bits (238), Expect = 4e-20
Identities = 68/218 (31%), Positives = 99/218 (45%), Gaps = 3/218 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A +++ + + +L G K G+T L +AA+K + L+ G D N
Sbjct: 602 LHVAAHYDNQKVALLLLDQG-ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV 660
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
G S+ LA GH+D+V L A+ + G T LH AA +V E ++ G
Sbjct: 661 TRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
VD T G+TPL V GN ++ + L+ A VN K +NG TPL A H +
Sbjct: 721 AHVD-AQTKMGYTPL-HVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 778
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLE 331
+ +LL A + G L +AR SVV L+
Sbjct: 779 INVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLK 816
Score = 93.2 bits (230), Expect = 3e-19
Identities = 58/194 (29%), Positives = 95/194 (48%), Gaps = 2/194 (1%)
Query: 137 VDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYL 196
VD + T L VA+++G +VK+L+ G ++ K G L +GH VV+ L
Sbjct: 261 VDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320
Query: 197 RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSG 256
A ++ G + LH A G H + ++ +++ VD D + + + V+A G
Sbjct: 321 LDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD--DVTNDYLTALHVAAHCG 378
Query: 257 NQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLE 316
+ +VA +L+D AN N K NG TPL +A N ++++LLL GA E G +
Sbjct: 379 HYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIH 438
Query: 317 MARVFDRQSVVSLL 330
+A ++VS L
Sbjct: 439 VAAFMGHVNIVSQL 452
Score = 92.8 bits (229), Expect = 4e-19
Identities = 65/219 (29%), Positives = 111/219 (50%), Gaps = 3/219 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
+H A + +++ +++ G + N G TAL +AA+ G +V+ LV +G V K
Sbjct: 437 IHVAAFMGHVNIVSQLMHHG-ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAK 495
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ L ++ G D+V+ L + GAS A G T LH +A GH V +++ G
Sbjct: 496 AKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHG 555
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
+ + T G+TPL V+A G VA+LL+ A+ + ++G TPL VA +++++
Sbjct: 556 ASLSIT-TKKGFTPL-HVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKV 613
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEE 332
LLLD+GA + G L +A ++ + + L E
Sbjct: 614 ALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE 652
Score = 85.9 bits (211), Expect = 5e-17
Identities = 57/164 (34%), Positives = 81/164 (49%), Gaps = 2/164 (1%)
Query: 173 KNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKD 232
K S + A AGHL+ ++G + G ALH A+ GH V+ +++
Sbjct: 37 KKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR 96
Query: 233 GCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEE 292
VD T G T L +++++G V +L+ GANVN + +NG TPL +A NH E
Sbjct: 97 EANVDAA-TKKGNTAL-HIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLE 154
Query: 293 LVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKK 336
+V+ LLD GA S+ E G L +A VVSLL E K
Sbjct: 155 VVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTK 198
Score = 85.9 bits (211), Expect = 5e-17
Identities = 51/157 (32%), Positives = 87/157 (55%), Gaps = 2/157 (1%)
Query: 151 AAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGG 210
AA+ G+ + NG D+N+ N +G ++L LA GH++VV L + A+ A G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 211 CTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGAN 270
TALH A+ G V++ ++ +G V+ + +G+TPL ++A + V L+D GA+
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVN-AQSQNGFTPLY-MAAQENHLEVVKFLLDNGAS 165
Query: 271 VNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVK 307
++ +G TPL VA+ H+++V LLL+ V+
Sbjct: 166 QSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVR 202
Score = 79.3 bits (194), Expect = 5e-15
Identities = 58/202 (28%), Positives = 102/202 (50%), Gaps = 12/202 (5%)
Query: 135 VKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVK 194
V +++ N+ G AL +A+++G+ +V L+ +V+ G +L +A AG +VVK
Sbjct: 65 VDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVK 124
Query: 195 YLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAV 254
L +GA+ A+ G T L+ AA H V+++++ +G + T G+TPL V+
Sbjct: 125 VLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLA-TEDGFTPL-AVALQ 182
Query: 255 SGNQRVASLLIDAGANVNVKDRNGKT---PLMVAVLNNHEELVQLLLDKGADASVKNEFG 311
G+ +V SLL++ D GK L +A + + LLL +A V+++ G
Sbjct: 183 QGHDQVVSLLLE-------NDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSG 235
Query: 312 KGVLEMARVFDRQSVVSLLEER 333
L +A + +V +LL R
Sbjct: 236 FTPLHIAAHYGNINVATLLLNR 257
Score = 79.0 bits (193), Expect = 6e-15
Identities = 61/227 (26%), Positives = 100/227 (44%), Gaps = 5/227 (2%)
Query: 104 TTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKIL 163
T R I+ H+ S +V++L K+D + G T L A+ G+ ++V++L
Sbjct: 264 TARNDITPLHV---ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320
Query: 164 VSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHC 223
+ + K +G L +A HL+ V+ L +H TALH AA GH
Sbjct: 321 LDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHY 380
Query: 224 SVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLM 283
V + ++ + +G+TPL ++ +V LL+ GA++ +G TP+
Sbjct: 381 KVAKVLLDKKANPN-AKALNGFTPL-HIACKKNRIKVMELLLKHGASIQAVTESGLTPIH 438
Query: 284 VAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
VA H +V L+ GA + N G+ L MA + VV L
Sbjct: 439 VAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Score = 78.6 bits (192), Expect = 8e-15
Identities = 59/227 (25%), Positives = 103/227 (45%), Gaps = 3/227 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH + ED+ +L G + + K GFT L VAA+ G + +L+ +
Sbjct: 536 LHLSAREGHEDVAAFLLDHG-ASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAA 594
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
SG L +A + + V L GAS A G T LH AA + +++ G
Sbjct: 595 GKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
+ + V T G + ++A G+ + SLL+ ANVN+ +++G TPL +A + +
Sbjct: 655 ADANAV-TRQGIASV-HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNV 712
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPK 340
++L+++GA + + G L + + +V+ L + K K
Sbjct: 713 AEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAK 759
Score = 72.0 bits (175), Expect = 7e-13
Identities = 41/130 (31%), Positives = 69/130 (53%), Gaps = 3/130 (2%)
Query: 103 STTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKI 162
+ TR+ I+S HL D +V +L G V++ NK G T L +AAQ+ + ++
Sbjct: 659 AVTRQGIASVHLAAQEGHVD---MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEV 715
Query: 163 LVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGH 222
LV+ G V+ + G L + C+ G++ +V +L +H A A+ G T LH AA GH
Sbjct: 716 LVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGH 775
Query: 223 CSVIEWMIKD 232
+I ++++
Sbjct: 776 THIINVLLQN 785
Score = 46.2 bits (108), Expect = 4e-05
Identities = 32/121 (26%), Positives = 58/121 (47%), Gaps = 2/121 (1%)
Query: 217 AADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDR 276
AA GH IK+G ++++ + + +++ G+ V S L+ ANV+ +
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNG--LNALHLASKEGHVEVVSELLQREANVDAATK 105
Query: 277 NGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKK 336
G T L +A L E+V++L+ GA+ + +++ G L MA + VV L +
Sbjct: 106 KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS 165
Query: 337 Q 337
Q
Sbjct: 166 Q 166
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 105 bits (261), Expect = 8e-23
Identities = 62/185 (33%), Positives = 102/185 (55%), Gaps = 3/185 (1%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LMLA 184
+V++L ++ N+ G T LM AA G+ + ++L+ +G +N + K+S L LA
Sbjct: 320 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
Query: 185 CYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
CY GHLD+V++L GA + + TAL A GH V ++ G +V++
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM--PADS 437
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
+ + ++A G+ +A+LLI+ GAN+ + G TPLM A HEE+V LLL +GA+
Sbjct: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
Query: 305 SVKNE 309
+ + E
Sbjct: 498 NAQTE 502
Score = 91.3 bits (225), Expect = 1e-18
Identities = 59/196 (30%), Positives = 97/196 (49%), Gaps = 1/196 (0%)
Query: 138 DVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLR 197
D NK T LM A+ GY +VK+L+ + DVN ++ +G +L AC G +D+VK L
Sbjct: 266 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Query: 198 RHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGN 257
GA+ + + G T L AA GH V ++ G ++ + + ++ G+
Sbjct: 326 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGH 384
Query: 258 QRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEM 317
+ L++AGA+ K T LM A ++ H E+ +LLLD GA ++ + + L +
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444
Query: 318 ARVFDRQSVVSLLEER 333
A + +LL ER
Sbjct: 445 AACGGHVELAALLIER 460
Score = 77.4 bits (189), Expect = 2e-14
Identities = 60/192 (31%), Positives = 94/192 (48%), Gaps = 7/192 (3%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
+ R+L +V++P + L +AA G+ L +L+ G ++ N G LM A
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
Query: 186 YAGHLDVVKYLRRHGASWQAR-DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
GH ++V L GA+ A+ + TAL A GG V +++IK G ++++ +
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--- 536
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
TPLM S G+ + L+ +GANV+ G T L A N H ++ +LL GAD
Sbjct: 537 -TPLMEASQ-EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
Query: 305 SVKNEFGKGVLE 316
K E K +LE
Sbjct: 595 D-KQEDMKTILE 605
Score = 74.7 bits (182), Expect = 1e-13
Identities = 58/196 (29%), Positives = 93/196 (47%), Gaps = 4/196 (2%)
Query: 147 ALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQAR 206
+L A G V+ L+ G VN G+ L LAC AG+ ++ + L A+ + R
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 207 -DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ G T L A+ GG+ +++ ++ +V+ + +G T L A G + +L+
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVN-SQSATGNTALTYACA-GGFVDIVKVLL 325
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV-KNEFGKGVLEMARVFDRQ 324
+ GAN+ + NG TPLM A H E+ ++LLD GA + NEF + L +A
Sbjct: 326 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385
Query: 325 SVVSLLEERKKKQRPK 340
+V L E Q K
Sbjct: 386 DMVRFLLEAGADQEHK 401
Score = 56.2 bits (134), Expect = 4e-08
Identities = 35/117 (29%), Positives = 60/117 (51%), Gaps = 4/117 (3%)
Query: 121 NDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS 180
++E + + + QG + + TAL +A G++ + L+ G D+ L +
Sbjct: 483 HEEMVALLLAQGANINAQT-EETQETALTLACCGGFSEVADFLIKAGADIELGCST---P 538
Query: 181 LMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVD 237
LM A GHL++VKYL GA+ A G TAL +A + GH V + +++ G ++D
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 105 bits (261), Expect = 8e-23
Identities = 62/185 (33%), Positives = 102/185 (55%), Gaps = 3/185 (1%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LMLA 184
+V++L ++ N+ G T LM AA G+ + ++L+ +G +N + K+S L LA
Sbjct: 309 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 368
Query: 185 CYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
CY GHLD+V++L GA + + TAL A GH V ++ G +V++
Sbjct: 369 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM--PADS 426
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
+ + ++A G+ +A+LLI+ GAN+ + G TPLM A HEE+V LLL +GA+
Sbjct: 427 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 486
Query: 305 SVKNE 309
+ + E
Sbjct: 487 NAQTE 491
Score = 91.3 bits (225), Expect = 1e-18
Identities = 59/196 (30%), Positives = 97/196 (49%), Gaps = 1/196 (0%)
Query: 138 DVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLR 197
D NK T LM A+ GY +VK+L+ + DVN ++ +G +L AC G +D+VK L
Sbjct: 255 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 314
Query: 198 RHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGN 257
GA+ + + G T L AA GH V ++ G ++ + + ++ G+
Sbjct: 315 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGH 373
Query: 258 QRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEM 317
+ L++AGA+ K T LM A ++ H E+ +LLLD GA ++ + + L +
Sbjct: 374 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 433
Query: 318 ARVFDRQSVVSLLEER 333
A + +LL ER
Sbjct: 434 AACGGHVELAALLIER 449
Score = 77.4 bits (189), Expect = 2e-14
Identities = 60/192 (31%), Positives = 94/192 (48%), Gaps = 7/192 (3%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
+ R+L +V++P + L +AA G+ L +L+ G ++ N G LM A
Sbjct: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
Query: 186 YAGHLDVVKYLRRHGASWQAR-DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
GH ++V L GA+ A+ + TAL A GG V +++IK G ++++ +
Sbjct: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--- 525
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
TPLM S G+ + L+ +GANV+ G T L A N H ++ +LL GAD
Sbjct: 526 -TPLMEASQ-EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
Query: 305 SVKNEFGKGVLE 316
K E K +LE
Sbjct: 584 D-KQEDMKTILE 594
Score = 76.3 bits (186), Expect = 4e-14
Identities = 68/261 (26%), Positives = 115/261 (44%), Gaps = 10/261 (3%)
Query: 85 LKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFG 144
L+ P + L+ + +P L +VS ++ + R+K + + G
Sbjct: 135 LRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALT---RMKAENSHNAG 191
Query: 145 FT---ALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGA 201
+L A G V+ L+ G VN G+ L LAC AG+ ++ + L A
Sbjct: 192 QVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 251
Query: 202 SWQAR-DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRV 260
+ + R + G T L A+ GG+ +++ ++ +V+ + +G T L A G +
Sbjct: 252 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVN-SQSATGNTALTYACA-GGFVDI 309
Query: 261 ASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV-KNEFGKGVLEMAR 319
+L++ GAN+ + NG TPLM A H E+ ++LLD GA + NEF + L +A
Sbjct: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369
Query: 320 VFDRQSVVSLLEERKKKQRPK 340
+V L E Q K
Sbjct: 370 YKGHLDMVRFLLEAGADQEHK 390
Score = 56.2 bits (134), Expect = 4e-08
Identities = 35/117 (29%), Positives = 60/117 (51%), Gaps = 4/117 (3%)
Query: 121 NDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS 180
++E + + + QG + + TAL +A G++ + L+ G D+ L +
Sbjct: 472 HEEMVALLLAQGANINAQT-EETQETALTLACCGGFSEVADFLIKAGADIELGCST---P 527
Query: 181 LMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVD 237
LM A GHL++VKYL GA+ A G TAL +A + GH V + +++ G ++D
Sbjct: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 105 bits (261), Expect = 8e-23
Identities = 62/185 (33%), Positives = 102/185 (55%), Gaps = 3/185 (1%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LMLA 184
+V++L ++ N+ G T LM AA G+ + ++L+ +G +N + K+S L LA
Sbjct: 320 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
Query: 185 CYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
CY GHLD+V++L GA + + TAL A GH V ++ G +V++
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM--PADS 437
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
+ + ++A G+ +A+LLI+ GAN+ + G TPLM A HEE+V LLL +GA+
Sbjct: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
Query: 305 SVKNE 309
+ + E
Sbjct: 498 NAQTE 502
Score = 99.8 bits (247), Expect = 3e-21
Identities = 78/249 (31%), Positives = 130/249 (52%), Gaps = 8/249 (3%)
Query: 67 ATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSVNDEDLL 126
++ E L P + + V S S Y P V + E L A + E+L
Sbjct: 1013 SSSQTTECLTPESCSQTTSNVASQSMPPVY-PSVDIDAHTESNHDTALTLACAGGHEEL- 1070
Query: 127 VRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LMLAC 185
V +L K++ +K GFT L++AA G+ +V+IL+ G D+ ++ KD+ L LAC
Sbjct: 1071 VSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130
Query: 186 YAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGS-- 243
G +VV L GA+ + R++ T L AA GG+ ++I+ ++ G E++ TGS
Sbjct: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN-SRTGSKL 1189
Query: 244 GWTPLMRVSAVSGNQRVASLLIDAGANVNVK-DRNGKTPLMVAVLNNHEELVQLLLDKGA 302
G +PLM ++A++G+ LL+D G+++N + + N T L +A E+V LLLD+ A
Sbjct: 1190 GISPLM-LAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA 1248
Query: 303 DASVKNEFG 311
+ + + G
Sbjct: 1249 NVEHRAKTG 1257
Score = 97.8 bits (242), Expect = 1e-20
Identities = 58/181 (32%), Positives = 99/181 (54%), Gaps = 3/181 (1%)
Query: 126 LVRIL--QGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LM 182
+++IL G + +K G + LM+AA G+ VK+L+ G+D+N + + +++ L
Sbjct: 1170 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALT 1229
Query: 183 LACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTG 242
LAC+ G +VV L A+ + R G T L AA GG+ V ++ G +V+
Sbjct: 1230 LACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1289
Query: 243 SGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGA 302
S + ++A G+ + LLI GA+++V+++ G TPL +A H ++VQLL+ GA
Sbjct: 1290 SSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349
Query: 303 D 303
D
Sbjct: 1350 D 1350
Score = 91.3 bits (225), Expect = 1e-18
Identities = 59/196 (30%), Positives = 97/196 (49%), Gaps = 1/196 (0%)
Query: 138 DVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLR 197
D NK T LM A+ GY +VK+L+ + DVN ++ +G +L AC G +D+VK L
Sbjct: 266 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Query: 198 RHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGN 257
GA+ + + G T L AA GH V ++ G ++ + + ++ G+
Sbjct: 326 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGH 384
Query: 258 QRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEM 317
+ L++AGA+ K T LM A ++ H E+ +LLLD GA ++ + + L +
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444
Query: 318 ARVFDRQSVVSLLEER 333
A + +LL ER
Sbjct: 445 AACGGHVELAALLIER 460
Score = 85.9 bits (211), Expect = 5e-17
Identities = 67/211 (31%), Positives = 106/211 (50%), Gaps = 7/211 (3%)
Query: 121 NDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS 180
++E + + + QG + + TAL +A G++ + L+ G D+ L +
Sbjct: 483 HEEMVALLLAQGANINAQT-EETQETALTLACCGGFSEVADFLIKAGADIELGCST---P 538
Query: 181 LMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVD 240
LM A GHL++VKYL GA+ A G TAL +A + GH V + +++ G +++
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 241 TGSGWTPLMRVSAVSGNQRVASLLIDAGANVN-VKDRNGKTPLMVAVLNNHEELVQLLLD 299
G G TPLM+ +A +G+ LI GANVN N T + +A H +V+LLL
Sbjct: 599 EG-GRTPLMK-AARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 300 KGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
GAD + + + G +L A +VVS L
Sbjct: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
Score = 84.7 bits (208), Expect = 1e-16
Identities = 62/194 (31%), Positives = 104/194 (53%), Gaps = 11/194 (5%)
Query: 141 NKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LMLACYAGHLDVVKYLRRH 199
N G+T LM AA++G+ +V +L++ G ++N + +++ L LAC G +V +L +
Sbjct: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527
Query: 200 GASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQR 259
GA + LG T L A+ GH ++++++ G V T +G T L + +G+
Sbjct: 528 GADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHAT-TATGDTALT-YACENGHTD 582
Query: 260 VASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGAD---ASVKNEFGKGVLE 316
VA +L+ AGA++ + G+TPLM A H VQ L+ KGA+ A+ N+ V+
Sbjct: 583 VADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANND--HTVVS 640
Query: 317 MARVFDRQSVVSLL 330
+A +VV LL
Sbjct: 641 LACAGGHLAVVELL 654
Score = 83.2 bits (204), Expect = 3e-16
Identities = 50/154 (32%), Positives = 80/154 (51%), Gaps = 1/154 (0%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
T LM A+Q+G+ LVK L+++G +V+ +G +L AC GH DV L + GA +
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
GG T L AA GH ++++I G V+ + T ++ ++ G+ V LL+
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT-VVSLACAGGHLAVVELLL 655
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLD 299
GA+ + ++G T L+ A H +V LLD
Sbjct: 656 AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 74.7 bits (182), Expect = 1e-13
Identities = 58/196 (29%), Positives = 93/196 (47%), Gaps = 4/196 (2%)
Query: 147 ALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQAR 206
+L A G V+ L+ G VN G+ L LAC AG+ ++ + L A+ + R
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 207 -DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ G T L A+ GG+ +++ ++ +V+ + +G T L A G + +L+
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVN-SQSATGNTALTYACA-GGFVDIVKVLL 325
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV-KNEFGKGVLEMARVFDRQ 324
+ GAN+ + NG TPLM A H E+ ++LLD GA + NEF + L +A
Sbjct: 326 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385
Query: 325 SVVSLLEERKKKQRPK 340
+V L E Q K
Sbjct: 386 DMVRFLLEAGADQEHK 401
Score = 74.3 bits (181), Expect = 1e-13
Identities = 59/202 (29%), Positives = 92/202 (45%), Gaps = 36/202 (17%)
Query: 169 DVNLKNGSGKDS-LMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIE 227
D++ S D+ L LAC GH ++V L A + RD G T L AA GH V+E
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 228 WMIKDGCEVDVVDTGSGWTPL--------------------------------MRVSAVS 255
++ G +++ + TPL + ++A
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 256 GNQRVASLLIDAGANVNVK--DRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKG 313
G + +L++AGA +N + + G +PLM+A +N H V+LLLD G+D + + E +
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 314 -VLEMARVFDRQSVVSLLEERK 334
L +A R VVSLL +RK
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRK 1247
Score = 67.8 bits (164), Expect = 1e-11
Identities = 63/230 (27%), Positives = 103/230 (44%), Gaps = 19/230 (8%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKN--GSGKDSLML 183
+V +L + V+ K G T LM AA GY + ++L+ G DVN S +L +
Sbjct: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1298
Query: 184 ACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGS 243
A GH + L GA R+ G T L A++GGH V++ +++ G +VD D
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
Query: 244 GWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHE---------ELV 294
TPLM G+ +V L+ VN + + +A + + E E +
Sbjct: 1359 -ITPLMSAFR-KGHVKVVQYLV---KEVNQFPSDIECMRYIATITDKELLKKCHQCVETI 1413
Query: 295 QLLLDKGADASVKNE---FGKGVLEMARVFDRQSVVSLLEERKKKQRPKK 341
D+ A + KN + LE +R R+ ++ E++K++R KK
Sbjct: 1414 VKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKK 1463
Score = 59.7 bits (143), Expect = 4e-09
Identities = 44/147 (29%), Positives = 69/147 (46%), Gaps = 3/147 (2%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
LV+ L V G TAL A + G+T + +L+ G D+ ++ G+ LM A
Sbjct: 550 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609
Query: 186 YAGHLDVVKYLRRHGASW-QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
AGHL V++L GA+ +A T + A GGH +V+E ++ G D
Sbjct: 610 RAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG--ADPTHRLKD 667
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANV 271
+ ++ +A G+ V S L+D NV
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNV 694
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 105 bits (261), Expect = 8e-23
Identities = 62/185 (33%), Positives = 102/185 (55%), Gaps = 3/185 (1%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LMLA 184
+V++L ++ N+ G T LM AA G+ + ++L+ +G +N + K+S L LA
Sbjct: 320 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
Query: 185 CYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
CY GHLD+V++L GA + + TAL A GH V ++ G +V++
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM--PADS 437
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
+ + ++A G+ +A+LLI+ GAN+ + G TPLM A HEE+V LLL +GA+
Sbjct: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
Query: 305 SVKNE 309
+ + E
Sbjct: 498 NAQTE 502
Score = 99.8 bits (247), Expect = 3e-21
Identities = 78/249 (31%), Positives = 130/249 (52%), Gaps = 8/249 (3%)
Query: 67 ATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSVNDEDLL 126
++ E L P + + V S S Y P V + E L A + E+L
Sbjct: 1013 SSSQTTECLTPESCSQTTSNVASQSMPPVY-PSVDIDAHTESNHDTALTLACAGGHEEL- 1070
Query: 127 VRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LMLAC 185
V +L K++ +K GFT L++AA G+ +V+IL+ G D+ ++ KD+ L LAC
Sbjct: 1071 VSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130
Query: 186 YAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGS-- 243
G +VV L GA+ + R++ T L AA GG+ ++I+ ++ G E++ TGS
Sbjct: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN-SRTGSKL 1189
Query: 244 GWTPLMRVSAVSGNQRVASLLIDAGANVNVK-DRNGKTPLMVAVLNNHEELVQLLLDKGA 302
G +PLM ++A++G+ LL+D G+++N + + N T L +A E+V LLLD+ A
Sbjct: 1190 GISPLM-LAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA 1248
Query: 303 DASVKNEFG 311
+ + + G
Sbjct: 1249 NVEHRAKTG 1257
Score = 97.8 bits (242), Expect = 1e-20
Identities = 58/181 (32%), Positives = 99/181 (54%), Gaps = 3/181 (1%)
Query: 126 LVRIL--QGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LM 182
+++IL G + +K G + LM+AA G+ VK+L+ G+D+N + + +++ L
Sbjct: 1170 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALT 1229
Query: 183 LACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTG 242
LAC+ G +VV L A+ + R G T L AA GG+ V ++ G +V+
Sbjct: 1230 LACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1289
Query: 243 SGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGA 302
S + ++A G+ + LLI GA+++V+++ G TPL +A H ++VQLL+ GA
Sbjct: 1290 SSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349
Query: 303 D 303
D
Sbjct: 1350 D 1350
Score = 91.3 bits (225), Expect = 1e-18
Identities = 59/196 (30%), Positives = 97/196 (49%), Gaps = 1/196 (0%)
Query: 138 DVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLR 197
D NK T LM A+ GY +VK+L+ + DVN ++ +G +L AC G +D+VK L
Sbjct: 266 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Query: 198 RHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGN 257
GA+ + + G T L AA GH V ++ G ++ + + ++ G+
Sbjct: 326 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGH 384
Query: 258 QRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEM 317
+ L++AGA+ K T LM A ++ H E+ +LLLD GA ++ + + L +
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444
Query: 318 ARVFDRQSVVSLLEER 333
A + +LL ER
Sbjct: 445 AACGGHVELAALLIER 460
Score = 85.9 bits (211), Expect = 5e-17
Identities = 67/211 (31%), Positives = 106/211 (50%), Gaps = 7/211 (3%)
Query: 121 NDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS 180
++E + + + QG + + TAL +A G++ + L+ G D+ L +
Sbjct: 483 HEEMVALLLAQGANINAQT-EETQETALTLACCGGFSEVADFLIKAGADIELGCST---P 538
Query: 181 LMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVD 240
LM A GHL++VKYL GA+ A G TAL +A + GH V + +++ G +++
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 241 TGSGWTPLMRVSAVSGNQRVASLLIDAGANVN-VKDRNGKTPLMVAVLNNHEELVQLLLD 299
G G TPLM+ +A +G+ LI GANVN N T + +A H +V+LLL
Sbjct: 599 EG-GRTPLMK-AARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 300 KGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
GAD + + + G +L A +VVS L
Sbjct: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
Score = 84.7 bits (208), Expect = 1e-16
Identities = 62/194 (31%), Positives = 104/194 (53%), Gaps = 11/194 (5%)
Query: 141 NKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS-LMLACYAGHLDVVKYLRRH 199
N G+T LM AA++G+ +V +L++ G ++N + +++ L LAC G +V +L +
Sbjct: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527
Query: 200 GASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQR 259
GA + LG T L A+ GH ++++++ G V T +G T L + +G+
Sbjct: 528 GADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHAT-TATGDTALT-YACENGHTD 582
Query: 260 VASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGAD---ASVKNEFGKGVLE 316
VA +L+ AGA++ + G+TPLM A H VQ L+ KGA+ A+ N+ V+
Sbjct: 583 VADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANND--HTVVS 640
Query: 317 MARVFDRQSVVSLL 330
+A +VV LL
Sbjct: 641 LACAGGHLAVVELL 654
Score = 83.2 bits (204), Expect = 3e-16
Identities = 50/154 (32%), Positives = 80/154 (51%), Gaps = 1/154 (0%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
T LM A+Q+G+ LVK L+++G +V+ +G +L AC GH DV L + GA +
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
GG T L AA GH ++++I G V+ + T ++ ++ G+ V LL+
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT-VVSLACAGGHLAVVELLL 655
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLD 299
GA+ + ++G T L+ A H +V LLD
Sbjct: 656 AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 74.7 bits (182), Expect = 1e-13
Identities = 58/196 (29%), Positives = 93/196 (47%), Gaps = 4/196 (2%)
Query: 147 ALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQAR 206
+L A G V+ L+ G VN G+ L LAC AG+ ++ + L A+ + R
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 207 -DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ G T L A+ GG+ +++ ++ +V+ + +G T L A G + +L+
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVN-SQSATGNTALTYACA-GGFVDIVKVLL 325
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV-KNEFGKGVLEMARVFDRQ 324
+ GAN+ + NG TPLM A H E+ ++LLD GA + NEF + L +A
Sbjct: 326 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385
Query: 325 SVVSLLEERKKKQRPK 340
+V L E Q K
Sbjct: 386 DMVRFLLEAGADQEHK 401
Score = 74.3 bits (181), Expect = 1e-13
Identities = 59/202 (29%), Positives = 92/202 (45%), Gaps = 36/202 (17%)
Query: 169 DVNLKNGSGKDS-LMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIE 227
D++ S D+ L LAC GH ++V L A + RD G T L AA GH V+E
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 228 WMIKDGCEVDVVDTGSGWTPL--------------------------------MRVSAVS 255
++ G +++ + TPL + ++A
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 256 GNQRVASLLIDAGANVNVK--DRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKG 313
G + +L++AGA +N + + G +PLM+A +N H V+LLLD G+D + + E +
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 314 -VLEMARVFDRQSVVSLLEERK 334
L +A R VVSLL +RK
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRK 1247
Score = 67.8 bits (164), Expect = 1e-11
Identities = 63/230 (27%), Positives = 103/230 (44%), Gaps = 19/230 (8%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKN--GSGKDSLML 183
+V +L + V+ K G T LM AA GY + ++L+ G DVN S +L +
Sbjct: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1298
Query: 184 ACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGS 243
A GH + L GA R+ G T L A++GGH V++ +++ G +VD D
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
Query: 244 GWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHE---------ELV 294
TPLM G+ +V L+ VN + + +A + + E E +
Sbjct: 1359 -ITPLMSAFR-KGHVKVVQYLV---KEVNQFPSDIECMRYIATITDKELLKKCHQCVETI 1413
Query: 295 QLLLDKGADASVKNE---FGKGVLEMARVFDRQSVVSLLEERKKKQRPKK 341
D+ A + KN + LE +R R+ ++ E++K++R KK
Sbjct: 1414 VKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKK 1463
Score = 59.7 bits (143), Expect = 4e-09
Identities = 44/147 (29%), Positives = 69/147 (46%), Gaps = 3/147 (2%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
LV+ L V G TAL A + G+T + +L+ G D+ ++ G+ LM A
Sbjct: 550 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609
Query: 186 YAGHLDVVKYLRRHGASW-QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
AGHL V++L GA+ +A T + A GGH +V+E ++ G D
Sbjct: 610 RAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG--ADPTHRLKD 667
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANV 271
+ ++ +A G+ V S L+D NV
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNV 694
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 103 bits (257), Expect = 2e-22
Identities = 69/217 (31%), Positives = 106/217 (48%), Gaps = 3/217 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + ++ +L G VD + G T L VA+++G T +VK+L+ G ++ K
Sbjct: 216 LHIAAHYGNVNVATLLLNRGAA-VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 274
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
G L A +GH VV+ L GA AR G + LH AA G H ++ +++
Sbjct: 275 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 334
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
VD D + + V+A G+ RV LL+D AN N + NG TPL +A N ++
Sbjct: 335 APVD--DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 392
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
++LL+ GA E G + +A ++V LL
Sbjct: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429
Score = 102 bits (254), Expect = 5e-22
Identities = 69/218 (31%), Positives = 107/218 (49%), Gaps = 3/218 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A +++ + + +L+ G K G+T L +AA+K ++ L++ G + N+
Sbjct: 579 LHVAAHYDNQKVALLLLEKG-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 637
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
G L LA GH D+V L GA+ G T+LH AA +V + + K G
Sbjct: 638 TKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG 697
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
+ D T G+TPL+ V+ GN ++ + L+ GANVN K +NG TPL A H +
Sbjct: 698 ADQD-AHTKLGYTPLI-VACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 755
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLE 331
+ +LL GA + G L +A+ SVV L+
Sbjct: 756 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLK 793
Score = 94.0 bits (232), Expect = 2e-19
Identities = 67/222 (30%), Positives = 106/222 (47%), Gaps = 33/222 (14%)
Query: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASW 203
GFT L +A +K +++++LV G + SG + +A + GHL++V L ++GAS
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436
Query: 204 QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDV------------------------- 238
++ G TALH AA G V+ ++++G VD
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496
Query: 239 -------VDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHE 291
T +G+TPL +SA G VAS+L++AGA ++ + G TPL VA
Sbjct: 497 QHMAHPDAATTNGYTPL-HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 555
Query: 292 ELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
++ +LLL + A A + G L +A +D Q V LL E+
Sbjct: 556 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 597
Score = 89.0 bits (219), Expect = 6e-18
Identities = 61/212 (28%), Positives = 102/212 (48%), Gaps = 2/212 (0%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
+V++L D G+T L ++A++G + +L+ G +L G L +A
Sbjct: 491 IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA 550
Query: 186 YAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGW 245
G LDV K L + A+ + G T LH AA + V +++ G +G+
Sbjct: 551 KYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT-AKNGY 609
Query: 246 TPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADAS 305
TPL ++A ++AS L++ GA N+ + G TPL +A H ++V LLLDKGA+
Sbjct: 610 TPL-HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668
Query: 306 VKNEFGKGVLEMARVFDRQSVVSLLEERKKKQ 337
+ + G L +A D+ +V +L + Q
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 700
Score = 87.4 bits (215), Expect = 2e-17
Identities = 72/232 (31%), Positives = 107/232 (46%), Gaps = 21/232 (9%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
L+ A N D++ +L+ G + GFT L VA Q+G+ + V IL+ N T
Sbjct: 113 LYMAAQENHIDVVKYLLENG-ANQSTATEDGFTPLAVALQQGHNQAVAILLENDT----- 166
Query: 174 NGSGKDSLMLACYAGHLDVVKYL-----RRHGASWQARDL------GGCTALHWAADGGH 222
GK L A D K H A Q++ + G T LH AA G+
Sbjct: 167 --KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 224
Query: 223 CSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPL 282
+V ++ G VD +G TPL V++ GN + LL+D G ++ K R+G TPL
Sbjct: 225 VNVATLLLNRGAAVDFT-ARNGITPL-HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 282
Query: 283 MVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERK 334
A + H+++V+LLL++GA + + G L MA D V L + K
Sbjct: 283 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 334
Score = 87.0 bits (214), Expect = 2e-17
Identities = 67/217 (30%), Positives = 109/217 (50%), Gaps = 3/217 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
+H A + ++++ +LQ G DV N G TAL +AA+ G +V+ L+ NG V+ +
Sbjct: 414 IHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 472
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ L +A G ++V+ L +H A A G T LH +A G V +++ G
Sbjct: 473 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 532
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
+ T G+TPL V+A G+ VA LL+ A + +NG TPL VA +++++
Sbjct: 533 AAHSLA-TKKGFTPL-HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 590
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
LLL+KGA + G L +A ++ + S L
Sbjct: 591 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 627
Score = 84.3 bits (207), Expect = 1e-16
Identities = 67/254 (26%), Positives = 117/254 (46%), Gaps = 38/254 (14%)
Query: 116 RAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNG 175
RA + D +V L+GG + ++ N+ G AL +AA++G+ LV+ L+ G+ V+
Sbjct: 16 RAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74
Query: 176 SGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCE 235
G +L +A AG +VVK L + GA+ A+ G T L+ AA H V+++++++G
Sbjct: 75 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134
Query: 236 VDVVDTGSGWTPL----------------------------MRVSAVSGNQRVASLLIDA 267
T G+TPL + ++A + + A+LL+
Sbjct: 135 QSTA-TEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 193
Query: 268 GANVNVKDR--------NGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMAR 319
N +V+ + +G TPL +A + + LLL++GA G L +A
Sbjct: 194 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 253
Query: 320 VFDRQSVVSLLEER 333
++V LL +R
Sbjct: 254 KRGNTNMVKLLLDR 267
Score = 81.6 bits (200), Expect = 9e-16
Identities = 56/166 (33%), Positives = 86/166 (51%), Gaps = 4/166 (2%)
Query: 172 LKNGSGKDSLMLACYAGHLD-VVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMI 230
L+ S + A AG+LD VV+YL+ G + G ALH AA GH +++ ++
Sbjct: 5 LQKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELL 63
Query: 231 KDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNH 290
G VD T G T L +++++G V +L+ GAN+N + +NG TPL +A NH
Sbjct: 64 GRGSSVDSA-TKKGNTAL-HIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 121
Query: 291 EELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKK 336
++V+ LL+ GA+ S E G L +A V++L E K
Sbjct: 122 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK 167
Score = 81.3 bits (199), Expect = 1e-15
Identities = 67/219 (30%), Positives = 107/219 (48%), Gaps = 3/219 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + + + +LQ DV + TAL VAA G+ R+ K+L+ + N +
Sbjct: 315 LHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNAR 373
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+G L +AC + V++ L ++GAS QA G T +H AA GH +++ ++++G
Sbjct: 374 ALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNG 433
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
DV + G T L ++A +G V L+ GA V+ + R +TPL +A E+
Sbjct: 434 ASPDVTNI-RGETAL-HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 491
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEE 332
VQLLL A G L ++ + V S+L E
Sbjct: 492 VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530
Score = 73.9 bits (180), Expect = 2e-13
Identities = 59/223 (26%), Positives = 97/223 (43%), Gaps = 3/223 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A D+ +LQ R D K G T L VAA ++ +L+ G +
Sbjct: 546 LHVAAKYGSLDVAKLLLQR-RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 604
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+G L +A + + L +GA G T LH A+ GH ++ ++ G
Sbjct: 605 AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 664
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
+ + T SG T L ++A VA +L GA+ + + G TPL+VA + ++
Sbjct: 665 ANIHM-STKSGLTSL-HLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 722
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKK 336
V LL +GA+ + K + G L A ++++L + K
Sbjct: 723 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765
Score = 59.3 bits (142), Expect = 5e-09
Identities = 39/124 (31%), Positives = 59/124 (47%), Gaps = 3/124 (2%)
Query: 104 TTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKIL 163
+T+ ++S HL + D+ + IL D K G+T L+VA G ++V L
Sbjct: 670 STKSGLTSLHL---AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 726
Query: 164 VSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHC 223
+ G +VN K +G L A GH ++ L +HGA A G TAL A G+
Sbjct: 727 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYI 786
Query: 224 SVIE 227
SV++
Sbjct: 787 SVVD 790
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 103 bits (257), Expect = 2e-22
Identities = 69/217 (31%), Positives = 106/217 (48%), Gaps = 3/217 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + ++ +L G VD + G T L VA+++G T +VK+L+ G ++ K
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAA-VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
G L A +GH VV+ L GA AR G + LH AA G H ++ +++
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
VD D + + V+A G+ RV LL+D AN N + NG TPL +A N ++
Sbjct: 356 APVD--DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
++LL+ GA E G + +A ++V LL
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Score = 102 bits (254), Expect = 5e-22
Identities = 69/218 (31%), Positives = 107/218 (49%), Gaps = 3/218 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A +++ + + +L+ G K G+T L +AA+K ++ L++ G + N+
Sbjct: 600 LHVAAHYDNQKVALLLLEKG-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 658
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
G L LA GH D+V L GA+ G T+LH AA +V + + K G
Sbjct: 659 TKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG 718
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
+ D T G+TPL+ V+ GN ++ + L+ GANVN K +NG TPL A H +
Sbjct: 719 ADQD-AHTKLGYTPLI-VACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLE 331
+ +LL GA + G L +A+ SVV L+
Sbjct: 777 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLK 814
Score = 94.0 bits (232), Expect = 2e-19
Identities = 67/222 (30%), Positives = 106/222 (47%), Gaps = 33/222 (14%)
Query: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASW 203
GFT L +A +K +++++LV G + SG + +A + GHL++V L ++GAS
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 204 QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDV------------------------- 238
++ G TALH AA G V+ ++++G VD
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 239 -------VDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHE 291
T +G+TPL +SA G VAS+L++AGA ++ + G TPL VA
Sbjct: 518 QHMAHPDAATTNGYTPL-HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 576
Query: 292 ELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
++ +LLL + A A + G L +A +D Q V LL E+
Sbjct: 577 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 618
Score = 89.0 bits (219), Expect = 6e-18
Identities = 61/212 (28%), Positives = 102/212 (48%), Gaps = 2/212 (0%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
+V++L D G+T L ++A++G + +L+ G +L G L +A
Sbjct: 512 IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA 571
Query: 186 YAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGW 245
G LDV K L + A+ + G T LH AA + V +++ G +G+
Sbjct: 572 KYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT-AKNGY 630
Query: 246 TPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADAS 305
TPL ++A ++AS L++ GA N+ + G TPL +A H ++V LLLDKGA+
Sbjct: 631 TPL-HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 306 VKNEFGKGVLEMARVFDRQSVVSLLEERKKKQ 337
+ + G L +A D+ +V +L + Q
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721
Score = 87.4 bits (215), Expect = 2e-17
Identities = 72/232 (31%), Positives = 107/232 (46%), Gaps = 21/232 (9%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
L+ A N D++ +L+ G + GFT L VA Q+G+ + V IL+ N T
Sbjct: 134 LYMAAQENHIDVVKYLLENG-ANQSTATEDGFTPLAVALQQGHNQAVAILLENDT----- 187
Query: 174 NGSGKDSLMLACYAGHLDVVKYL-----RRHGASWQARDL------GGCTALHWAADGGH 222
GK L A D K H A Q++ + G T LH AA G+
Sbjct: 188 --KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 245
Query: 223 CSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPL 282
+V ++ G VD +G TPL V++ GN + LL+D G ++ K R+G TPL
Sbjct: 246 VNVATLLLNRGAAVDFT-ARNGITPL-HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303
Query: 283 MVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERK 334
A + H+++V+LLL++GA + + G L MA D V L + K
Sbjct: 304 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Score = 87.0 bits (214), Expect = 2e-17
Identities = 67/217 (30%), Positives = 109/217 (50%), Gaps = 3/217 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
+H A + ++++ +LQ G DV N G TAL +AA+ G +V+ L+ NG V+ +
Sbjct: 435 IHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 493
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ L +A G ++V+ L +H A A G T LH +A G V +++ G
Sbjct: 494 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
+ T G+TPL V+A G+ VA LL+ A + +NG TPL VA +++++
Sbjct: 554 AAHSLA-TKKGFTPL-HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 611
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
LLL+KGA + G L +A ++ + S L
Sbjct: 612 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648
Score = 84.3 bits (207), Expect = 1e-16
Identities = 67/254 (26%), Positives = 117/254 (46%), Gaps = 38/254 (14%)
Query: 116 RAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNG 175
RA + D +V L+GG + ++ N+ G AL +AA++G+ LV+ L+ G+ V+
Sbjct: 37 RAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 176 SGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCE 235
G +L +A AG +VVK L + GA+ A+ G T L+ AA H V+++++++G
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 236 VDVVDTGSGWTPL----------------------------MRVSAVSGNQRVASLLIDA 267
T G+TPL + ++A + + A+LL+
Sbjct: 156 QSTA-TEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 268 GANVNVKDR--------NGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMAR 319
N +V+ + +G TPL +A + + LLL++GA G L +A
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274
Query: 320 VFDRQSVVSLLEER 333
++V LL +R
Sbjct: 275 KRGNTNMVKLLLDR 288
Score = 81.6 bits (200), Expect = 9e-16
Identities = 56/165 (33%), Positives = 85/165 (51%), Gaps = 4/165 (2%)
Query: 173 KNGSGKDSLMLACYAGHLD-VVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIK 231
K S + A AG+LD VV+YL+ G + G ALH AA GH +++ ++
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85
Query: 232 DGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHE 291
G VD T G T L +++++G V +L+ GAN+N + +NG TPL +A NH
Sbjct: 86 RGSSVDSA-TKKGNTAL-HIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143
Query: 292 ELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKK 336
++V+ LL+ GA+ S E G L +A V++L E K
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK 188
Score = 81.3 bits (199), Expect = 1e-15
Identities = 67/219 (30%), Positives = 107/219 (48%), Gaps = 3/219 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + + + +LQ DV + TAL VAA G+ R+ K+L+ + N +
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNAR 394
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+G L +AC + V++ L ++GAS QA G T +H AA GH +++ ++++G
Sbjct: 395 ALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNG 454
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
DV + G T L ++A +G V L+ GA V+ + R +TPL +A E+
Sbjct: 455 ASPDVTNI-RGETAL-HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 512
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEE 332
VQLLL A G L ++ + V S+L E
Sbjct: 513 VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
Score = 73.9 bits (180), Expect = 2e-13
Identities = 59/223 (26%), Positives = 97/223 (43%), Gaps = 3/223 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A D+ +LQ R D K G T L VAA ++ +L+ G +
Sbjct: 567 LHVAAKYGSLDVAKLLLQR-RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 625
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+G L +A + + L +GA G T LH A+ GH ++ ++ G
Sbjct: 626 AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
+ + T SG T L ++A VA +L GA+ + + G TPL+VA + ++
Sbjct: 686 ANIHM-STKSGLTSL-HLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKK 336
V LL +GA+ + K + G L A ++++L + K
Sbjct: 744 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
Score = 59.3 bits (142), Expect = 5e-09
Identities = 39/124 (31%), Positives = 59/124 (47%), Gaps = 3/124 (2%)
Query: 104 TTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKIL 163
+T+ ++S HL + D+ + IL D K G+T L+VA G ++V L
Sbjct: 691 STKSGLTSLHL---AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 164 VSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHC 223
+ G +VN K +G L A GH ++ L +HGA A G TAL A G+
Sbjct: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYI 807
Query: 224 SVIE 227
SV++
Sbjct: 808 SVVD 811
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 103 bits (257), Expect = 2e-22
Identities = 69/217 (31%), Positives = 106/217 (48%), Gaps = 3/217 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + ++ +L G VD + G T L VA+++G T +VK+L+ G ++ K
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAA-VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
G L A +GH VV+ L GA AR G + LH AA G H ++ +++
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
VD D + + V+A G+ RV LL+D AN N + NG TPL +A N ++
Sbjct: 356 APVD--DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
++LL+ GA E G + +A ++V LL
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Score = 102 bits (254), Expect = 5e-22
Identities = 69/218 (31%), Positives = 107/218 (49%), Gaps = 3/218 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A +++ + + +L+ G K G+T L +AA+K ++ L++ G + N+
Sbjct: 600 LHVAAHYDNQKVALLLLEKG-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 658
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
G L LA GH D+V L GA+ G T+LH AA +V + + K G
Sbjct: 659 TKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG 718
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
+ D T G+TPL+ V+ GN ++ + L+ GANVN K +NG TPL A H +
Sbjct: 719 ADQD-AHTKLGYTPLI-VACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLE 331
+ +LL GA + G L +A+ SVV L+
Sbjct: 777 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLK 814
Score = 94.0 bits (232), Expect = 2e-19
Identities = 67/222 (30%), Positives = 106/222 (47%), Gaps = 33/222 (14%)
Query: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASW 203
GFT L +A +K +++++LV G + SG + +A + GHL++V L ++GAS
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 204 QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDV------------------------- 238
++ G TALH AA G V+ ++++G VD
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 239 -------VDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHE 291
T +G+TPL +SA G VAS+L++AGA ++ + G TPL VA
Sbjct: 518 QHMAHPDAATTNGYTPL-HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 576
Query: 292 ELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
++ +LLL + A A + G L +A +D Q V LL E+
Sbjct: 577 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 618
Score = 89.0 bits (219), Expect = 6e-18
Identities = 61/212 (28%), Positives = 102/212 (48%), Gaps = 2/212 (0%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
+V++L D G+T L ++A++G + +L+ G +L G L +A
Sbjct: 512 IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA 571
Query: 186 YAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGW 245
G LDV K L + A+ + G T LH AA + V +++ G +G+
Sbjct: 572 KYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT-AKNGY 630
Query: 246 TPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADAS 305
TPL ++A ++AS L++ GA N+ + G TPL +A H ++V LLLDKGA+
Sbjct: 631 TPL-HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 306 VKNEFGKGVLEMARVFDRQSVVSLLEERKKKQ 337
+ + G L +A D+ +V +L + Q
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721
Score = 87.4 bits (215), Expect = 2e-17
Identities = 72/232 (31%), Positives = 107/232 (46%), Gaps = 21/232 (9%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
L+ A N D++ +L+ G + GFT L VA Q+G+ + V IL+ N T
Sbjct: 134 LYMAAQENHIDVVKYLLENG-ANQSTATEDGFTPLAVALQQGHNQAVAILLENDT----- 187
Query: 174 NGSGKDSLMLACYAGHLDVVKYL-----RRHGASWQARDL------GGCTALHWAADGGH 222
GK L A D K H A Q++ + G T LH AA G+
Sbjct: 188 --KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 245
Query: 223 CSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPL 282
+V ++ G VD +G TPL V++ GN + LL+D G ++ K R+G TPL
Sbjct: 246 VNVATLLLNRGAAVDFT-ARNGITPL-HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303
Query: 283 MVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERK 334
A + H+++V+LLL++GA + + G L MA D V L + K
Sbjct: 304 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Score = 87.0 bits (214), Expect = 2e-17
Identities = 67/217 (30%), Positives = 109/217 (50%), Gaps = 3/217 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
+H A + ++++ +LQ G DV N G TAL +AA+ G +V+ L+ NG V+ +
Sbjct: 435 IHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 493
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ L +A G ++V+ L +H A A G T LH +A G V +++ G
Sbjct: 494 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
+ T G+TPL V+A G+ VA LL+ A + +NG TPL VA +++++
Sbjct: 554 AAHSLA-TKKGFTPL-HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 611
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
LLL+KGA + G L +A ++ + S L
Sbjct: 612 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648
Score = 84.3 bits (207), Expect = 1e-16
Identities = 67/254 (26%), Positives = 117/254 (46%), Gaps = 38/254 (14%)
Query: 116 RAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNG 175
RA + D +V L+GG + ++ N+ G AL +AA++G+ LV+ L+ G+ V+
Sbjct: 37 RAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 176 SGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCE 235
G +L +A AG +VVK L + GA+ A+ G T L+ AA H V+++++++G
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 236 VDVVDTGSGWTPL----------------------------MRVSAVSGNQRVASLLIDA 267
T G+TPL + ++A + + A+LL+
Sbjct: 156 QSTA-TEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 268 GANVNVKDR--------NGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMAR 319
N +V+ + +G TPL +A + + LLL++GA G L +A
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274
Query: 320 VFDRQSVVSLLEER 333
++V LL +R
Sbjct: 275 KRGNTNMVKLLLDR 288
Score = 81.6 bits (200), Expect = 9e-16
Identities = 56/165 (33%), Positives = 85/165 (51%), Gaps = 4/165 (2%)
Query: 173 KNGSGKDSLMLACYAGHLD-VVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIK 231
K S + A AG+LD VV+YL+ G + G ALH AA GH +++ ++
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85
Query: 232 DGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHE 291
G VD T G T L +++++G V +L+ GAN+N + +NG TPL +A NH
Sbjct: 86 RGSSVDSA-TKKGNTAL-HIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143
Query: 292 ELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKK 336
++V+ LL+ GA+ S E G L +A V++L E K
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK 188
Score = 81.3 bits (199), Expect = 1e-15
Identities = 67/219 (30%), Positives = 107/219 (48%), Gaps = 3/219 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + + + +LQ DV + TAL VAA G+ R+ K+L+ + N +
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNAR 394
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+G L +AC + V++ L ++GAS QA G T +H AA GH +++ ++++G
Sbjct: 395 ALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNG 454
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
DV + G T L ++A +G V L+ GA V+ + R +TPL +A E+
Sbjct: 455 ASPDVTNI-RGETAL-HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 512
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEE 332
VQLLL A G L ++ + V S+L E
Sbjct: 513 VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
Score = 73.9 bits (180), Expect = 2e-13
Identities = 59/223 (26%), Positives = 97/223 (43%), Gaps = 3/223 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A D+ +LQ R D K G T L VAA ++ +L+ G +
Sbjct: 567 LHVAAKYGSLDVAKLLLQR-RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 625
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+G L +A + + L +GA G T LH A+ GH ++ ++ G
Sbjct: 626 AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
+ + T SG T L ++A VA +L GA+ + + G TPL+VA + ++
Sbjct: 686 ANIHM-STKSGLTSL-HLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKK 336
V LL +GA+ + K + G L A ++++L + K
Sbjct: 744 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
Score = 59.3 bits (142), Expect = 5e-09
Identities = 39/124 (31%), Positives = 59/124 (47%), Gaps = 3/124 (2%)
Query: 104 TTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKIL 163
+T+ ++S HL + D+ + IL D K G+T L+VA G ++V L
Sbjct: 691 STKSGLTSLHL---AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 164 VSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHC 223
+ G +VN K +G L A GH ++ L +HGA A G TAL A G+
Sbjct: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYI 807
Query: 224 SVIE 227
SV++
Sbjct: 808 SVVD 811
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 102 bits (254), Expect = 5e-22
Identities = 69/217 (31%), Positives = 103/217 (47%), Gaps = 3/217 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A N +D R+L VD + G+T L +AAQ + + ++LVS D NL
Sbjct: 432 LHFAAQ-NGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH 490
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
GK L +A Y GH+ +VK L GA A+ T LH A + G I+ ++K G
Sbjct: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
D +D SG+ PL +A G + +L+ GA++ + G TPL +A H E+
Sbjct: 551 AVPDALDQ-SGYGPL-HTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEI 608
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
+ LL + A+ L +A ++VVS L
Sbjct: 609 IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
Score = 86.3 bits (212), Expect = 4e-17
Identities = 64/221 (28%), Positives = 110/221 (49%), Gaps = 3/221 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH AV + +L+ G V D ++ G+ L AA +G + K+L+ G + L
Sbjct: 531 LHLAVERGKVRAIQHLLKSGAVP-DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP 589
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
G L LA Y GHL+++ L A+ A T LH AA G +V+ +++ G
Sbjct: 590 THQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCG 649
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
+ + + SGWTPL S V +LL + ANV+ +++ G TP +A L + +
Sbjct: 650 ADPNAAEQ-SGWTPLHLAVQRSTFLSVINLL-EHHANVHARNKVGWTPAHLAALKGNTAI 707
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERK 334
+++L++ GA V++ L++A +Q ++S LE ++
Sbjct: 708 LKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKE 748
Score = 82.0 bits (201), Expect = 7e-16
Identities = 61/204 (29%), Positives = 94/204 (46%), Gaps = 2/204 (0%)
Query: 127 VRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACY 186
VR+L V VD G+T L++AAQ L +L+++G D N + G L A
Sbjct: 378 VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQ 437
Query: 187 AGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWT 246
G + L HGA A++ G T LH AA +V ++ + ++ + G T
Sbjct: 438 NGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE-AEGKT 496
Query: 247 PLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV 306
PL V+A G+ + LL GA ++ + RN +TPL +AV +Q LL GA
Sbjct: 497 PL-HVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDA 555
Query: 307 KNEFGKGVLEMARVFDRQSVVSLL 330
++ G G L A + + +L
Sbjct: 556 LDQSGYGPLHTAAARGKYLICKML 579
Score = 80.5 bits (197), Expect = 2e-15
Identities = 55/165 (33%), Positives = 81/165 (49%), Gaps = 4/165 (2%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
T L +G V++L+++ DV+ + SG L++A D+ L HGA
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
D G LH+AA G ++ G VD + GWTPL ++A + + VA LL+
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQER-EGWTPL-HLAAQNNFENVARLLV 481
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGA--DASVKN 308
A+ N+ + GKTPL VA H LV+LL +GA DA +N
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRN 526
Score = 52.0 bits (123), Expect = 8e-07
Identities = 37/123 (30%), Positives = 59/123 (47%), Gaps = 2/123 (1%)
Query: 212 TALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANV 271
T LH+ G + ++ +VD T SG+TPL+ ++A + +LL+ GA+
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDC-QTASGYTPLL-IAAQDQQPDLCALLLAHGADA 421
Query: 272 NVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLE 331
N D +G PL A N + +LLLD GA + G L +A + ++V LL
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
Query: 332 ERK 334
R+
Sbjct: 482 SRQ 484
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 101 bits (251), Expect = 1e-21
Identities = 63/203 (31%), Positives = 111/203 (54%), Gaps = 5/203 (2%)
Query: 119 SVNDEDLL-VRILQGGRVKVDV--PNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNG 175
++ND+++ ++ L G DV PNK G L++AA G +++++L+ G+ +++++
Sbjct: 351 AINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDK 410
Query: 176 SGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCE 235
G +++ A GH+D +K+L + +D G ALH AA GH V + + G
Sbjct: 411 GGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSN 470
Query: 236 VDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQ 295
++ D TPL +A G VA L +AG NVN+K+R G+TPL+ A + ++V+
Sbjct: 471 PNIQDKEEE-TPL-HCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVE 528
Query: 296 LLLDKGADASVKNEFGKGVLEMA 318
L + GAD + ++ G L +A
Sbjct: 529 CLAEHGADLNACDKDGHIALHLA 551
Score = 97.8 bits (242), Expect = 1e-20
Identities = 66/198 (33%), Positives = 97/198 (48%), Gaps = 2/198 (1%)
Query: 138 DVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLR 197
++ +K T L AA GY + K L G +VN+KN G+ L+ A G+ D+V+ L
Sbjct: 472 NIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLA 531
Query: 198 RHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGN 257
HGA A D G ALH A VI+ ++ GC VD D G TPL V+ GN
Sbjct: 532 EHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDR-HGNTPL-HVACKDGN 589
Query: 258 QRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEM 317
+ L +A N+++ ++ G+TPL +A N ++V+ L GA GK ++
Sbjct: 590 MPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDL 649
Query: 318 ARVFDRQSVVSLLEERKK 335
AR + V LL +K
Sbjct: 650 ARSEQHEHVAGLLARLRK 667
Score = 86.7 bits (213), Expect = 3e-17
Identities = 48/164 (29%), Positives = 85/164 (51%), Gaps = 2/164 (1%)
Query: 169 DVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEW 228
DVN N G L++A G++ +++ L + G+ +D GG A++WAA GH +++
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 229 MIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 288
+ ++ C +DV D + V+A G+ VA LL G+N N++D+ +TPL A +
Sbjct: 431 LSENKCPLDVKDKSGEMA--LHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWH 488
Query: 289 NHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEE 332
+ + + L + G + ++KN G+ L A +V L E
Sbjct: 489 GYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAE 532
Score = 68.6 bits (166), Expect = 8e-12
Identities = 49/161 (30%), Positives = 79/161 (49%), Gaps = 2/161 (1%)
Query: 137 VDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYL 196
V++ N+ G T L+ A+ +GY +V+ L +G D+N + G +L LA ++V+K L
Sbjct: 504 VNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTL 563
Query: 197 RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSG 256
G +D G T LH A G+ ++ + + C +D + G TPL ++A +G
Sbjct: 564 LSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLD-ISNKYGRTPL-HLAANNG 621
Query: 257 NQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLL 297
V L GA+V +GKT +A HE + LL
Sbjct: 622 ILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 33.1 bits (74), Expect = 0.37
Identities = 25/85 (29%), Positives = 37/85 (43%), Gaps = 1/85 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + ++V + + +D+ NK+G T L +AA G +V+ L G V
Sbjct: 581 LHVACKDGNMPIVVALCEAN-CNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEAL 639
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRR 198
GK + LA H V L R
Sbjct: 640 TTDGKTAEDLARSEQHEHVAGLLAR 664
Score = 32.0 bits (71), Expect = 0.83
Identities = 16/65 (24%), Positives = 34/65 (52%)
Query: 270 NVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSL 329
+VN +++G PL++A + +++QLL+ +G+ V+++ G + A +
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 330 LEERK 334
L E K
Sbjct: 431 LSENK 435
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 100 bits (250), Expect = 1e-21
Identities = 61/167 (36%), Positives = 91/167 (54%), Gaps = 2/167 (1%)
Query: 137 VDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYL 196
VD N+ G T LM+AA++G +VK L+ NG + NL++ +L+ A GH+ +V+ L
Sbjct: 31 VDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEEL 90
Query: 197 RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSG 256
+ G + + RD+GG TAL WA G V+E ++ G V S + + +A G
Sbjct: 91 LKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW--AAGRG 148
Query: 257 NQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGAD 303
+ + LL+ GA VN D+ G TPL+ A H E V+ LL GAD
Sbjct: 149 HADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
Score = 96.3 bits (238), Expect = 4e-20
Identities = 58/168 (34%), Positives = 98/168 (58%), Gaps = 4/168 (2%)
Query: 137 VDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYL 196
V++ +K G TALM+A+++G+T +V+ L+ GT VN+ + SG L+ A GH+++V+ L
Sbjct: 229 VNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRAL 288
Query: 197 RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDV-VDTGSGWTPLMRVSAVS 255
+ A R TAL+WA + G+ +++ +++ C D + T G TPL++ + +
Sbjct: 289 LQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ--CNPDTEICTKDGETPLIKATKMR 346
Query: 256 GNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGAD 303
N V LL+D GA V+ D+ G TPL +A+ +L +LLL D
Sbjct: 347 -NIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
Score = 92.0 bits (227), Expect = 7e-19
Identities = 70/249 (28%), Positives = 113/249 (45%), Gaps = 19/249 (7%)
Query: 84 RLKVTSPSGECEYSPL-VSVSTTREPISSEHLHRAVSVNDEDL----------------L 126
+ K EC +PL ++ I E + + N EDL +
Sbjct: 27 KCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHI 86
Query: 127 VRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACY 186
V L V ++ + G+TALM A KG T +V++L+S+G + ++ ++ A
Sbjct: 87 VEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAG 146
Query: 187 AGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWT 246
GH D+V L ++GA D G T L WAA GH ++ ++ G +VD G+
Sbjct: 147 RGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD--QEGANSM 204
Query: 247 PLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV 306
+ V+ G + ++ NVN+ D++G T LM+A H E+VQ LLD G ++
Sbjct: 205 TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI 264
Query: 307 KNEFGKGVL 315
+ G VL
Sbjct: 265 PDRSGDTVL 273
Score = 86.7 bits (213), Expect = 3e-17
Identities = 58/202 (28%), Positives = 97/202 (48%), Gaps = 2/202 (0%)
Query: 137 VDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYL 196
VD TAL+VA + GYT+ VK ++ +VNL + G +LM+A GH ++V+ L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Query: 197 RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSG 256
G D G T L A GGH ++ +++ ++D+ G + + G
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDI--RGQDNKTALYWAVEKG 313
Query: 257 NQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLE 316
N + ++ + + ++G+TPL+ A + E+V+LLLDKGA S ++ G L
Sbjct: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
Query: 317 MARVFDRQSVVSLLEERKKKQR 338
+A + + LL K R
Sbjct: 374 IAIRGRSRKLAELLLRNPKDGR 395
Score = 84.3 bits (207), Expect = 1e-16
Identities = 52/152 (34%), Positives = 82/152 (53%), Gaps = 2/152 (1%)
Query: 160 VKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAAD 219
+K L+ DV+ +N G+ LM+A G+L++VK L ++GA+ DL TAL A+
Sbjct: 21 LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
Query: 220 GGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGK 279
GH ++E ++K G ++ D G GWT LM + G V LL+ GAN +V
Sbjct: 81 EGHVHIVEELLKCGVNLEHRDMG-GWTALM-WACYKGRTDVVELLLSHGANPSVTGLYSV 138
Query: 280 TPLMVAVLNNHEELVQLLLDKGADASVKNEFG 311
P++ A H ++V LLL GA + +++G
Sbjct: 139 YPIIWAAGRGHADIVHLLLQNGAKVNCSDKYG 170
Score = 43.1 bits (100), Expect = 4e-04
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 1/87 (1%)
Query: 244 GWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGAD 303
G TPLM ++A GN + LI GAN N++D + T L+ A H +V+ LL G +
Sbjct: 38 GQTPLM-IAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVN 96
Query: 304 ASVKNEFGKGVLEMARVFDRQSVVSLL 330
++ G L A R VV LL
Sbjct: 97 LEHRDMGGWTALMWACYKGRTDVVELL 123
Score = 41.2 bits (95), Expect = 0.001
Identities = 29/107 (27%), Positives = 50/107 (46%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
+VR L +D+ + TAL A +KG +V+ ++ D + G+ L+ A
Sbjct: 284 IVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKAT 343
Query: 186 YAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKD 232
+++VV+ L GA A D G T LH A G + E ++++
Sbjct: 344 KMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRN 390
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 99.8 bits (247), Expect = 3e-21
Identities = 59/174 (33%), Positives = 97/174 (55%), Gaps = 2/174 (1%)
Query: 129 ILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAG 188
+L G V N+ G L AA++G+ ++V++L+ G DVNL + G+ LM+A G
Sbjct: 1089 LLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEG 1148
Query: 189 HLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPL 248
HL V++L GA+ + D G +AL WA GH +V+++++++G +D D +G TPL
Sbjct: 1149 HLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK-NGRTPL 1207
Query: 249 MRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGA 302
++A G+ L++ GA + D +G PL A+ + +V LL KGA
Sbjct: 1208 -DLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
Score = 77.8 bits (190), Expect = 1e-14
Identities = 71/255 (27%), Positives = 111/255 (43%), Gaps = 48/255 (18%)
Query: 123 EDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLM 182
E+++ +L+ G +D ++ G TAL AA G+ +LV +L G V+ + G+ +L+
Sbjct: 940 EEVVTLLLEFGAC-LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALV 998
Query: 183 LACYAGHLDVVKY---------------LRRHGASWQA---------------------- 205
+ GH D+++Y LR+ A QA
Sbjct: 999 HSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKE 1058
Query: 206 --------RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGN 257
L G TAL AA G V E ++ G V T P + +A G+
Sbjct: 1059 HEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVS--RTNRRGVPPLFCAARQGH 1116
Query: 258 QRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEM 317
++ LL++ G +VN+ D+ G+TPLMVA H V+ LL KGA S ++ G L
Sbjct: 1117 WQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSW 1176
Query: 318 ARVFDRQSVVSLLEE 332
A + ++VV L E
Sbjct: 1177 ACLKGHRAVVQYLVE 1191
Score = 68.6 bits (166), Expect = 8e-12
Identities = 47/139 (33%), Positives = 70/139 (50%), Gaps = 1/139 (0%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
+VR+L V++ +K G T LMVAA +G+ V+ L+S G ++ + G +L AC
Sbjct: 1119 IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWAC 1178
Query: 186 YAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGW 245
GH VV+YL GA+ D G T L AA G + ++++ G ++ VD SG
Sbjct: 1179 LKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVD-HSGM 1237
Query: 246 TPLMRVSAVSGNQRVASLL 264
PL R V +LL
Sbjct: 1238 RPLDRAIGCRNTSVVVALL 1256
Score = 47.0 bits (110), Expect = 3e-05
Identities = 62/238 (26%), Positives = 89/238 (37%), Gaps = 48/238 (20%)
Query: 144 GFTALMVAAQKGYTRLVKI---LVSNGTDVNLKNG--SGKDSLMLACYAGHLDVVKYLRR 198
G +A + + + YT VK+ L+ G +VN + + L + + GH +VV L
Sbjct: 889 GLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLE 948
Query: 199 HGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVD------------TGSG-- 244
GA G TAL +AA GH ++ + K G VD +D G G
Sbjct: 949 FGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDI 1008
Query: 245 --------WTP----------------LMRVSAVSGNQRVASLLI----DAGANVNVKDR 276
W+P + +A G+ V L+ + VN D
Sbjct: 1009 LQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDT 1068
Query: 277 N-GKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
G+T L A E+ +LLL GA S N G L A +V LL ER
Sbjct: 1069 LWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLER 1126
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 99.8 bits (247), Expect = 3e-21
Identities = 59/174 (33%), Positives = 97/174 (55%), Gaps = 2/174 (1%)
Query: 129 ILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAG 188
+L G V N+ G L AA++G+ ++V++L+ G DVNL + G+ LM+A G
Sbjct: 1097 LLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEG 1156
Query: 189 HLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPL 248
HL V++L GA+ + D G +AL WA GH +V+++++++G +D D +G TPL
Sbjct: 1157 HLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK-NGRTPL 1215
Query: 249 MRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGA 302
++A G+ L++ GA + D +G PL A+ + +V LL KGA
Sbjct: 1216 -DLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
Score = 77.8 bits (190), Expect = 1e-14
Identities = 71/255 (27%), Positives = 111/255 (43%), Gaps = 48/255 (18%)
Query: 123 EDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLM 182
E+++ +L+ G +D ++ G TAL AA G+ +LV +L G V+ + G+ +L+
Sbjct: 948 EEVVTLLLEFGAC-LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALV 1006
Query: 183 LACYAGHLDVVKY---------------LRRHGASWQA---------------------- 205
+ GH D+++Y LR+ A QA
Sbjct: 1007 HSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKE 1066
Query: 206 --------RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGN 257
L G TAL AA G V E ++ G V T P + +A G+
Sbjct: 1067 HEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVS--RTNRRGVPPLFCAARQGH 1124
Query: 258 QRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEM 317
++ LL++ G +VN+ D+ G+TPLMVA H V+ LL KGA S ++ G L
Sbjct: 1125 WQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSW 1184
Query: 318 ARVFDRQSVVSLLEE 332
A + ++VV L E
Sbjct: 1185 ACLKGHRAVVQYLVE 1199
Score = 68.6 bits (166), Expect = 8e-12
Identities = 47/139 (33%), Positives = 70/139 (50%), Gaps = 1/139 (0%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
+VR+L V++ +K G T LMVAA +G+ V+ L+S G ++ + G +L AC
Sbjct: 1127 IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWAC 1186
Query: 186 YAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGW 245
GH VV+YL GA+ D G T L AA G + ++++ G ++ VD SG
Sbjct: 1187 LKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVD-HSGM 1245
Query: 246 TPLMRVSAVSGNQRVASLL 264
PL R V +LL
Sbjct: 1246 RPLDRAIGCRNTSVVVALL 1264
Score = 47.0 bits (110), Expect = 3e-05
Identities = 62/238 (26%), Positives = 89/238 (37%), Gaps = 48/238 (20%)
Query: 144 GFTALMVAAQKGYTRLVKI---LVSNGTDVNLKNG--SGKDSLMLACYAGHLDVVKYLRR 198
G +A + + + YT VK+ L+ G +VN + + L + + GH +VV L
Sbjct: 897 GLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLE 956
Query: 199 HGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVD------------TGSG-- 244
GA G TAL +AA GH ++ + K G VD +D G G
Sbjct: 957 FGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDI 1016
Query: 245 --------WTP----------------LMRVSAVSGNQRVASLLI----DAGANVNVKDR 276
W+P + +A G+ V L+ + VN D
Sbjct: 1017 LQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDT 1076
Query: 277 N-GKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
G+T L A E+ +LLL GA S N G L A +V LL ER
Sbjct: 1077 LWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLER 1134
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 99.8 bits (247), Expect = 3e-21
Identities = 68/220 (30%), Positives = 107/220 (48%), Gaps = 3/220 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + ++ +L G V+ + G T L +A+++G +V++L+ G + K
Sbjct: 243 LHIAAHYENLNVAQLLLNRG-ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 301
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
L A GH+ + + L HGA QA+ G + +H AA G H + +++
Sbjct: 302 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 361
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
E+D + T TPL V+A G+ RVA +L+D GA N + NG TPL +A NH +
Sbjct: 362 AEIDDI-TLDHLTPL-HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 419
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
++LLL GA E G L +A +V L +R
Sbjct: 420 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 459
Score = 94.7 bits (234), Expect = 1e-19
Identities = 61/190 (32%), Positives = 98/190 (51%), Gaps = 2/190 (1%)
Query: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASW 203
GFT L +A +K + R++++L+ G ++ SG L +A + GHL +VK L + GAS
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463
Query: 204 QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASL 263
++ T LH AA GH V ++++++ +V+ TPL +A G+ + L
Sbjct: 464 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN-AKAKDDQTPL-HCAARIGHTNMVKL 521
Query: 264 LIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDR 323
L++ AN N+ G TPL +A H E V LL+K A + + G L +A + +
Sbjct: 522 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 581
Query: 324 QSVVSLLEER 333
V LL ER
Sbjct: 582 VRVAELLLER 591
Score = 92.0 bits (227), Expect = 7e-19
Identities = 69/218 (31%), Positives = 105/218 (48%), Gaps = 3/218 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH AV N+ D++ +L G P G+T L +AA++ + + L+ G N +
Sbjct: 606 LHVAVHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ G L LA GH ++V L A+ + G T LH A GH V + +IK G
Sbjct: 665 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 724
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
VD T G+TPL V++ GN ++ L+ A+VN K + G +PL A H ++
Sbjct: 725 VMVDAT-TRMGYTPL-HVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 782
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLE 331
V LLL GA + + G L +A+ SV +L+
Sbjct: 783 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820
Score = 90.9 bits (224), Expect = 2e-18
Identities = 64/216 (29%), Positives = 104/216 (48%), Gaps = 2/216 (0%)
Query: 125 LLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLA 184
++VR+L +++ K T L AA+ G+ R+ +IL+ +G + K +G + +A
Sbjct: 286 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 345
Query: 185 CYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
HLD V+ L ++ A L T LH AA GH V + ++ G + + +G
Sbjct: 346 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL-NG 404
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
+TPL ++ + RV LL+ GA+++ +G TPL VA H +V+ LL +GA
Sbjct: 405 FTPL-HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463
Query: 305 SVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPK 340
+V N + L MA V L + K K K
Sbjct: 464 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 499
Score = 89.0 bits (219), Expect = 6e-18
Identities = 66/220 (30%), Positives = 106/220 (48%), Gaps = 34/220 (15%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A N ++ +L+ G +D + G T L VA+ G+ +VK L+ G N+
Sbjct: 408 LHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 466
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
N + L +A AGH +V KYL ++ A A+ T LH AA GH ++++ ++++
Sbjct: 467 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 526
Query: 234 CEVDVVDTGSGWTPL--------------------------------MRVSAVSGNQRVA 261
++ T +G TPL + V+A G RVA
Sbjct: 527 ANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 585
Query: 262 SLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKG 301
LL++ A+ N +NG TPL VAV +N+ ++V+LLL +G
Sbjct: 586 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625
Score = 87.8 bits (216), Expect = 1e-17
Identities = 69/224 (30%), Positives = 106/224 (47%), Gaps = 30/224 (13%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A ++V +L + ++ K G TAL +AA G +V+ LV+ G +VN +
Sbjct: 82 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 140
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ G L +A HL+VVK+L +GA+ G T L A GH +V+ +I G
Sbjct: 141 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200
Query: 234 CEVDV----------------------------VDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ V V + +G+TPL ++A N VA LL+
Sbjct: 201 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPL-HIAAHYENLNVAQLLL 259
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNE 309
+ GA+VN +NG TPL +A + +V+LLLD+GA K +
Sbjct: 260 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 303
Score = 85.9 bits (211), Expect = 5e-17
Identities = 65/207 (31%), Positives = 108/207 (52%), Gaps = 3/207 (1%)
Query: 127 VRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACY 186
VR+L ++D T L VAA G+ R+ K+L+ G N + +G L +AC
Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 413
Query: 187 AGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWT 246
H+ V++ L + GAS A G T LH A+ GH +++ +++ G +V + T
Sbjct: 414 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV-KVET 472
Query: 247 PLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV 306
PL ++A +G+ VA L+ A VN K ++ +TPL A H +V+LLL+ A+ ++
Sbjct: 473 PL-HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 531
Query: 307 KNEFGKGVLEM-ARVFDRQSVVSLLEE 332
G L + AR ++V++LLE+
Sbjct: 532 ATTAGHTPLHIAAREGHVETVLALLEK 558
Score = 79.7 bits (195), Expect = 3e-15
Identities = 60/201 (29%), Positives = 100/201 (49%), Gaps = 11/201 (5%)
Query: 85 LKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFG 144
+K+ P G +SP + T LH A N ++ +LQ G + + G
Sbjct: 618 VKLLLPRGGSPHSPAWNGYTP--------LHIAAKQNQVEVARSLLQYGG-SANAESVQG 668
Query: 145 FTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQ 204
T L +AAQ+G+ +V +L+S + NL N SG L L GH+ V L +HG
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 728
Query: 205 ARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLL 264
A G T LH A+ G+ +++++++ +V+ T G++PL + +A G+ + +LL
Sbjct: 729 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ-AAQQGHTDIVTLL 786
Query: 265 IDAGANVNVKDRNGKTPLMVA 285
+ GA+ N +G TPL +A
Sbjct: 787 LKNGASPNEVSSDGTTPLAIA 807
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/162 (32%), Positives = 79/162 (48%), Gaps = 2/162 (1%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
T+ + AA+ G + NG D+N N +G + L LA GH+ +V L +
Sbjct: 47 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
G TALH AA G V+ ++ G V+ + G+TPL ++A + V L+
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLY-MAAQENHLEVVKFLL 164
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVK 307
+ GAN NV +G TPL VA+ HE +V L++ G V+
Sbjct: 165 ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 206
Score = 74.7 bits (182), Expect = 1e-13
Identities = 65/222 (29%), Positives = 94/222 (42%), Gaps = 35/222 (15%)
Query: 142 KFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKY------ 195
K GFT L VAA+ G R+ ++L+ N +G L +A + +LD+VK
Sbjct: 567 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626
Query: 196 ---------------------------LRRHGASWQARDLGGCTALHWAADGGHCSVIEW 228
L ++G S A + G T LH AA GH ++
Sbjct: 627 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 686
Query: 229 MIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 288
++ + + SG TPL V A G+ VA +LI G V+ R G TPL VA
Sbjct: 687 LLSKQANGN-LGNKSGLTPLHLV-AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 744
Query: 289 NHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
+ +LV+ LL AD + K + G L A +V+LL
Sbjct: 745 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 786
Score = 70.5 bits (171), Expect = 2e-12
Identities = 49/159 (30%), Positives = 78/159 (49%), Gaps = 4/159 (2%)
Query: 173 KNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCS-VIEWMIK 231
K S + A +G+LD R+G + G LH A+ GH V+E + K
Sbjct: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
Query: 232 DGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHE 291
E+ + T + ++A++G V L++ GANVN + + G TPL +A NH
Sbjct: 101 ---EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 157
Query: 292 ELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
E+V+ LL+ GA+ +V E G L +A ++VV+ L
Sbjct: 158 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 196
Score = 55.8 bits (133), Expect = 5e-08
Identities = 48/169 (28%), Positives = 71/169 (42%), Gaps = 12/169 (7%)
Query: 63 YTGYATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEH----LHRAV 118
Y G A V+G+ P L + + G E L+ + ++ LH
Sbjct: 657 YGGSANAESVQGVTP-------LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 709
Query: 119 SVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGK 178
+ +++ G V VD + G+T L VA+ G +LVK L+ + DVN K G
Sbjct: 710 QEGHVPVADVLIKHG-VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 768
Query: 179 DSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIE 227
L A GH D+V L ++GAS G T L A G+ SV +
Sbjct: 769 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 817
Score = 32.7 bits (73), Expect = 0.49
Identities = 30/141 (21%), Positives = 62/141 (43%), Gaps = 2/141 (1%)
Query: 197 RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSG 256
RR+ + + + T+ AA G+ +++G VD+ + +++ G
Sbjct: 32 RRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEG 89
Query: 257 NQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLE 316
+ ++ L+ + + G T L +A L +E+V+ L++ GA+ + +++ G L
Sbjct: 90 HVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLY 149
Query: 317 MARVFDRQSVVSLLEERKKKQ 337
MA + VV L E Q
Sbjct: 150 MAAQENHLEVVKFLLENGANQ 170
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 99.8 bits (247), Expect = 3e-21
Identities = 68/220 (30%), Positives = 107/220 (48%), Gaps = 3/220 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + ++ +L G V+ + G T L +A+++G +V++L+ G + K
Sbjct: 210 LHIAAHYENLNVAQLLLNRG-ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
L A GH+ + + L HGA QA+ G + +H AA G H + +++
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
E+D + T TPL V+A G+ RVA +L+D GA N + NG TPL +A NH +
Sbjct: 329 AEIDDI-TLDHLTPL-HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
++LLL GA E G L +A +V L +R
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426
Score = 94.7 bits (234), Expect = 1e-19
Identities = 61/190 (32%), Positives = 98/190 (51%), Gaps = 2/190 (1%)
Query: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASW 203
GFT L +A +K + R++++L+ G ++ SG L +A + GHL +VK L + GAS
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 204 QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASL 263
++ T LH AA GH V ++++++ +V+ TPL +A G+ + L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN-AKAKDDQTPL-HCAARIGHTNMVKL 488
Query: 264 LIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDR 323
L++ AN N+ G TPL +A H E V LL+K A + + G L +A + +
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
Query: 324 QSVVSLLEER 333
V LL ER
Sbjct: 549 VRVAELLLER 558
Score = 92.0 bits (227), Expect = 7e-19
Identities = 69/218 (31%), Positives = 105/218 (48%), Gaps = 3/218 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH AV N+ D++ +L G P G+T L +AA++ + + L+ G N +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ G L LA GH ++V L A+ + G T LH A GH V + +IK G
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
VD T G+TPL V++ GN ++ L+ A+VN K + G +PL A H ++
Sbjct: 692 VMVDAT-TRMGYTPL-HVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLE 331
V LLL GA + + G L +A+ SV +L+
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 90.9 bits (224), Expect = 2e-18
Identities = 64/216 (29%), Positives = 104/216 (48%), Gaps = 2/216 (0%)
Query: 125 LLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLA 184
++VR+L +++ K T L AA+ G+ R+ +IL+ +G + K +G + +A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 185 CYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
HLD V+ L ++ A L T LH AA GH V + ++ G + + +G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL-NG 371
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
+TPL ++ + RV LL+ GA+++ +G TPL VA H +V+ LL +GA
Sbjct: 372 FTPL-HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 305 SVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPK 340
+V N + L MA V L + K K K
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Score = 89.0 bits (219), Expect = 6e-18
Identities = 66/220 (30%), Positives = 106/220 (48%), Gaps = 34/220 (15%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A N ++ +L+ G +D + G T L VA+ G+ +VK L+ G N+
Sbjct: 375 LHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
N + L +A AGH +V KYL ++ A A+ T LH AA GH ++++ ++++
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Query: 234 CEVDVVDTGSGWTPL--------------------------------MRVSAVSGNQRVA 261
++ T +G TPL + V+A G RVA
Sbjct: 494 ANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 262 SLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKG 301
LL++ A+ N +NG TPL VAV +N+ ++V+LLL +G
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 87.8 bits (216), Expect = 1e-17
Identities = 69/224 (30%), Positives = 106/224 (47%), Gaps = 30/224 (13%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A ++V +L + ++ K G TAL +AA G +V+ LV+ G +VN +
Sbjct: 49 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ G L +A HL+VVK+L +GA+ G T L A GH +V+ +I G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 234 CEVDV----------------------------VDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ V V + +G+TPL ++A N VA LL+
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPL-HIAAHYENLNVAQLLL 226
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNE 309
+ GA+VN +NG TPL +A + +V+LLLD+GA K +
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 85.9 bits (211), Expect = 5e-17
Identities = 65/207 (31%), Positives = 108/207 (52%), Gaps = 3/207 (1%)
Query: 127 VRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACY 186
VR+L ++D T L VAA G+ R+ K+L+ G N + +G L +AC
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 187 AGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWT 246
H+ V++ L + GAS A G T LH A+ GH +++ +++ G +V + T
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV-KVET 439
Query: 247 PLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV 306
PL ++A +G+ VA L+ A VN K ++ +TPL A H +V+LLL+ A+ ++
Sbjct: 440 PL-HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 307 KNEFGKGVLEM-ARVFDRQSVVSLLEE 332
G L + AR ++V++LLE+
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEK 525
Score = 79.7 bits (195), Expect = 3e-15
Identities = 60/201 (29%), Positives = 100/201 (49%), Gaps = 11/201 (5%)
Query: 85 LKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFG 144
+K+ P G +SP + T LH A N ++ +LQ G + + G
Sbjct: 585 VKLLLPRGGSPHSPAWNGYTP--------LHIAAKQNQVEVARSLLQYGG-SANAESVQG 635
Query: 145 FTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQ 204
T L +AAQ+G+ +V +L+S + NL N SG L L GH+ V L +HG
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 205 ARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLL 264
A G T LH A+ G+ +++++++ +V+ T G++PL + +A G+ + +LL
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ-AAQQGHTDIVTLL 753
Query: 265 IDAGANVNVKDRNGKTPLMVA 285
+ GA+ N +G TPL +A
Sbjct: 754 LKNGASPNEVSSDGTTPLAIA 774
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/162 (32%), Positives = 79/162 (48%), Gaps = 2/162 (1%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
T+ + AA+ G + NG D+N N +G + L LA GH+ +V L +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
G TALH AA G V+ ++ G V+ + G+TPL ++A + V L+
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLY-MAAQENHLEVVKFLL 131
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVK 307
+ GAN NV +G TPL VA+ HE +V L++ G V+
Sbjct: 132 ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 74.7 bits (182), Expect = 1e-13
Identities = 65/222 (29%), Positives = 94/222 (42%), Gaps = 35/222 (15%)
Query: 142 KFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKY------ 195
K GFT L VAA+ G R+ ++L+ N +G L +A + +LD+VK
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 196 ---------------------------LRRHGASWQARDLGGCTALHWAADGGHCSVIEW 228
L ++G S A + G T LH AA GH ++
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 229 MIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 288
++ + + SG TPL V A G+ VA +LI G V+ R G TPL VA
Sbjct: 654 LLSKQANGN-LGNKSGLTPLHLV-AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 711
Query: 289 NHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
+ +LV+ LL AD + K + G L A +V+LL
Sbjct: 712 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 70.9 bits (172), Expect = 2e-12
Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 4/162 (2%)
Query: 170 VNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCS-VIEW 228
V + S + A +G+LD R+G + G LH A+ GH V+E
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 229 MIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 288
+ K E+ + T + ++A++G V L++ GANVN + + G TPL +A
Sbjct: 65 LHK---EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 289 NHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
NH E+V+ LL+ GA+ +V E G L +A ++VV+ L
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 55.8 bits (133), Expect = 5e-08
Identities = 48/169 (28%), Positives = 71/169 (42%), Gaps = 12/169 (7%)
Query: 63 YTGYATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEH----LHRAV 118
Y G A V+G+ P L + + G E L+ + ++ LH
Sbjct: 624 YGGSANAESVQGVTP-------LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Query: 119 SVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGK 178
+ +++ G V VD + G+T L VA+ G +LVK L+ + DVN K G
Sbjct: 677 QEGHVPVADVLIKHG-VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 179 DSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIE 227
L A GH D+V L ++GAS G T L A G+ SV +
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Score = 33.1 bits (74), Expect = 0.37
Identities = 29/132 (21%), Positives = 58/132 (43%), Gaps = 2/132 (1%)
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
R+ T+ AA G+ +++G VD+ + +++ G+ ++ L+
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQS 325
+ + G T L +A L +E+V+ L++ GA+ + +++ G L MA +
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 326 VVSLLEERKKKQ 337
VV L E Q
Sbjct: 126 VVKFLLENGANQ 137
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 99.8 bits (247), Expect = 3e-21
Identities = 68/220 (30%), Positives = 107/220 (48%), Gaps = 3/220 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + ++ +L G V+ + G T L +A+++G +V++L+ G + K
Sbjct: 210 LHIAAHYENLNVAQLLLNRG-ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
L A GH+ + + L HGA QA+ G + +H AA G H + +++
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
E+D + T TPL V+A G+ RVA +L+D GA N + NG TPL +A NH +
Sbjct: 329 AEIDDI-TLDHLTPL-HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
++LLL GA E G L +A +V L +R
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426
Score = 94.7 bits (234), Expect = 1e-19
Identities = 61/190 (32%), Positives = 98/190 (51%), Gaps = 2/190 (1%)
Query: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASW 203
GFT L +A +K + R++++L+ G ++ SG L +A + GHL +VK L + GAS
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 204 QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASL 263
++ T LH AA GH V ++++++ +V+ TPL +A G+ + L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN-AKAKDDQTPL-HCAARIGHTNMVKL 488
Query: 264 LIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDR 323
L++ AN N+ G TPL +A H E V LL+K A + + G L +A + +
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
Query: 324 QSVVSLLEER 333
V LL ER
Sbjct: 549 VRVAELLLER 558
Score = 92.0 bits (227), Expect = 7e-19
Identities = 69/218 (31%), Positives = 105/218 (48%), Gaps = 3/218 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH AV N+ D++ +L G P G+T L +AA++ + + L+ G N +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ G L LA GH ++V L A+ + G T LH A GH V + +IK G
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
VD T G+TPL V++ GN ++ L+ A+VN K + G +PL A H ++
Sbjct: 692 VMVDAT-TRMGYTPL-HVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLE 331
V LLL GA + + G L +A+ SV +L+
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 90.9 bits (224), Expect = 2e-18
Identities = 64/216 (29%), Positives = 104/216 (48%), Gaps = 2/216 (0%)
Query: 125 LLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLA 184
++VR+L +++ K T L AA+ G+ R+ +IL+ +G + K +G + +A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 185 CYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
HLD V+ L ++ A L T LH AA GH V + ++ G + + +G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL-NG 371
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
+TPL ++ + RV LL+ GA+++ +G TPL VA H +V+ LL +GA
Sbjct: 372 FTPL-HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 305 SVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPK 340
+V N + L MA V L + K K K
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Score = 89.0 bits (219), Expect = 6e-18
Identities = 66/220 (30%), Positives = 106/220 (48%), Gaps = 34/220 (15%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A N ++ +L+ G +D + G T L VA+ G+ +VK L+ G N+
Sbjct: 375 LHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
N + L +A AGH +V KYL ++ A A+ T LH AA GH ++++ ++++
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Query: 234 CEVDVVDTGSGWTPL--------------------------------MRVSAVSGNQRVA 261
++ T +G TPL + V+A G RVA
Sbjct: 494 ANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 262 SLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKG 301
LL++ A+ N +NG TPL VAV +N+ ++V+LLL +G
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 87.8 bits (216), Expect = 1e-17
Identities = 69/224 (30%), Positives = 106/224 (47%), Gaps = 30/224 (13%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A ++V +L + ++ K G TAL +AA G +V+ LV+ G +VN +
Sbjct: 49 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ G L +A HL+VVK+L +GA+ G T L A GH +V+ +I G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 234 CEVDV----------------------------VDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ V V + +G+TPL ++A N VA LL+
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPL-HIAAHYENLNVAQLLL 226
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNE 309
+ GA+VN +NG TPL +A + +V+LLLD+GA K +
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 85.9 bits (211), Expect = 5e-17
Identities = 65/207 (31%), Positives = 108/207 (52%), Gaps = 3/207 (1%)
Query: 127 VRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACY 186
VR+L ++D T L VAA G+ R+ K+L+ G N + +G L +AC
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 187 AGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWT 246
H+ V++ L + GAS A G T LH A+ GH +++ +++ G +V + T
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV-KVET 439
Query: 247 PLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV 306
PL ++A +G+ VA L+ A VN K ++ +TPL A H +V+LLL+ A+ ++
Sbjct: 440 PL-HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 307 KNEFGKGVLEM-ARVFDRQSVVSLLEE 332
G L + AR ++V++LLE+
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEK 525
Score = 79.7 bits (195), Expect = 3e-15
Identities = 60/201 (29%), Positives = 100/201 (49%), Gaps = 11/201 (5%)
Query: 85 LKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFG 144
+K+ P G +SP + T LH A N ++ +LQ G + + G
Sbjct: 585 VKLLLPRGGSPHSPAWNGYTP--------LHIAAKQNQVEVARSLLQYGG-SANAESVQG 635
Query: 145 FTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQ 204
T L +AAQ+G+ +V +L+S + NL N SG L L GH+ V L +HG
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 205 ARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLL 264
A G T LH A+ G+ +++++++ +V+ T G++PL + +A G+ + +LL
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ-AAQQGHTDIVTLL 753
Query: 265 IDAGANVNVKDRNGKTPLMVA 285
+ GA+ N +G TPL +A
Sbjct: 754 LKNGASPNEVSSDGTTPLAIA 774
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/162 (32%), Positives = 79/162 (48%), Gaps = 2/162 (1%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
T+ + AA+ G + NG D+N N +G + L LA GH+ +V L +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
G TALH AA G V+ ++ G V+ + G+TPL ++A + V L+
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLY-MAAQENHLEVVKFLL 131
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVK 307
+ GAN NV +G TPL VA+ HE +V L++ G V+
Sbjct: 132 ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 74.7 bits (182), Expect = 1e-13
Identities = 65/222 (29%), Positives = 94/222 (42%), Gaps = 35/222 (15%)
Query: 142 KFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKY------ 195
K GFT L VAA+ G R+ ++L+ N +G L +A + +LD+VK
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 196 ---------------------------LRRHGASWQARDLGGCTALHWAADGGHCSVIEW 228
L ++G S A + G T LH AA GH ++
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 229 MIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 288
++ + + SG TPL V A G+ VA +LI G V+ R G TPL VA
Sbjct: 654 LLSKQANGN-LGNKSGLTPLHLV-AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 711
Query: 289 NHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
+ +LV+ LL AD + K + G L A +V+LL
Sbjct: 712 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 70.9 bits (172), Expect = 2e-12
Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 4/162 (2%)
Query: 170 VNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCS-VIEW 228
V + S + A +G+LD R+G + G LH A+ GH V+E
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 229 MIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 288
+ K E+ + T + ++A++G V L++ GANVN + + G TPL +A
Sbjct: 65 LHK---EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 289 NHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
NH E+V+ LL+ GA+ +V E G L +A ++VV+ L
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 55.8 bits (133), Expect = 5e-08
Identities = 48/169 (28%), Positives = 71/169 (42%), Gaps = 12/169 (7%)
Query: 63 YTGYATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEH----LHRAV 118
Y G A V+G+ P L + + G E L+ + ++ LH
Sbjct: 624 YGGSANAESVQGVTP-------LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Query: 119 SVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGK 178
+ +++ G V VD + G+T L VA+ G +LVK L+ + DVN K G
Sbjct: 677 QEGHVPVADVLIKHG-VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 179 DSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIE 227
L A GH D+V L ++GAS G T L A G+ SV +
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Score = 33.1 bits (74), Expect = 0.37
Identities = 29/132 (21%), Positives = 58/132 (43%), Gaps = 2/132 (1%)
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
R+ T+ AA G+ +++G VD+ + +++ G+ ++ L+
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQS 325
+ + G T L +A L +E+V+ L++ GA+ + +++ G L MA +
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 326 VVSLLEERKKKQ 337
VV L E Q
Sbjct: 126 VVKFLLENGANQ 137
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 99.8 bits (247), Expect = 3e-21
Identities = 68/220 (30%), Positives = 107/220 (48%), Gaps = 3/220 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + ++ +L G V+ + G T L +A+++G +V++L+ G + K
Sbjct: 210 LHIAAHYENLNVAQLLLNRG-ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
L A GH+ + + L HGA QA+ G + +H AA G H + +++
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
E+D + T TPL V+A G+ RVA +L+D GA N + NG TPL +A NH +
Sbjct: 329 AEIDDI-TLDHLTPL-HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
++LLL GA E G L +A +V L +R
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426
Score = 94.7 bits (234), Expect = 1e-19
Identities = 61/190 (32%), Positives = 98/190 (51%), Gaps = 2/190 (1%)
Query: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASW 203
GFT L +A +K + R++++L+ G ++ SG L +A + GHL +VK L + GAS
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 204 QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASL 263
++ T LH AA GH V ++++++ +V+ TPL +A G+ + L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN-AKAKDDQTPL-HCAARIGHTNMVKL 488
Query: 264 LIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDR 323
L++ AN N+ G TPL +A H E V LL+K A + + G L +A + +
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
Query: 324 QSVVSLLEER 333
V LL ER
Sbjct: 549 VRVAELLLER 558
Score = 92.0 bits (227), Expect = 7e-19
Identities = 69/218 (31%), Positives = 105/218 (48%), Gaps = 3/218 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH AV N+ D++ +L G P G+T L +AA++ + + L+ G N +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ G L LA GH ++V L A+ + G T LH A GH V + +IK G
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
VD T G+TPL V++ GN ++ L+ A+VN K + G +PL A H ++
Sbjct: 692 VMVDAT-TRMGYTPL-HVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLE 331
V LLL GA + + G L +A+ SV +L+
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 90.9 bits (224), Expect = 2e-18
Identities = 64/216 (29%), Positives = 104/216 (48%), Gaps = 2/216 (0%)
Query: 125 LLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLA 184
++VR+L +++ K T L AA+ G+ R+ +IL+ +G + K +G + +A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 185 CYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
HLD V+ L ++ A L T LH AA GH V + ++ G + + +G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL-NG 371
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
+TPL ++ + RV LL+ GA+++ +G TPL VA H +V+ LL +GA
Sbjct: 372 FTPL-HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 305 SVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPK 340
+V N + L MA V L + K K K
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Score = 89.0 bits (219), Expect = 6e-18
Identities = 66/220 (30%), Positives = 106/220 (48%), Gaps = 34/220 (15%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A N ++ +L+ G +D + G T L VA+ G+ +VK L+ G N+
Sbjct: 375 LHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
N + L +A AGH +V KYL ++ A A+ T LH AA GH ++++ ++++
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Query: 234 CEVDVVDTGSGWTPL--------------------------------MRVSAVSGNQRVA 261
++ T +G TPL + V+A G RVA
Sbjct: 494 ANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 262 SLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKG 301
LL++ A+ N +NG TPL VAV +N+ ++V+LLL +G
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 87.8 bits (216), Expect = 1e-17
Identities = 69/224 (30%), Positives = 106/224 (47%), Gaps = 30/224 (13%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A ++V +L + ++ K G TAL +AA G +V+ LV+ G +VN +
Sbjct: 49 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ G L +A HL+VVK+L +GA+ G T L A GH +V+ +I G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 234 CEVDV----------------------------VDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ V V + +G+TPL ++A N VA LL+
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPL-HIAAHYENLNVAQLLL 226
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNE 309
+ GA+VN +NG TPL +A + +V+LLLD+GA K +
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 85.9 bits (211), Expect = 5e-17
Identities = 65/207 (31%), Positives = 108/207 (52%), Gaps = 3/207 (1%)
Query: 127 VRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACY 186
VR+L ++D T L VAA G+ R+ K+L+ G N + +G L +AC
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 187 AGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWT 246
H+ V++ L + GAS A G T LH A+ GH +++ +++ G +V + T
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-T 439
Query: 247 PLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV 306
PL ++A +G+ VA L+ A VN K ++ +TPL A H +V+LLL+ A+ ++
Sbjct: 440 PL-HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 307 KNEFGKGVLEM-ARVFDRQSVVSLLEE 332
G L + AR ++V++LLE+
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEK 525
Score = 79.7 bits (195), Expect = 3e-15
Identities = 60/201 (29%), Positives = 100/201 (49%), Gaps = 11/201 (5%)
Query: 85 LKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFG 144
+K+ P G +SP + T LH A N ++ +LQ G + + G
Sbjct: 585 VKLLLPRGGSPHSPAWNGYTP--------LHIAAKQNQVEVARSLLQYGG-SANAESVQG 635
Query: 145 FTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQ 204
T L +AAQ+G+ +V +L+S + NL N SG L L GH+ V L +HG
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 205 ARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLL 264
A G T LH A+ G+ +++++++ +V+ T G++PL + +A G+ + +LL
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ-AAQQGHTDIVTLL 753
Query: 265 IDAGANVNVKDRNGKTPLMVA 285
+ GA+ N +G TPL +A
Sbjct: 754 LKNGASPNEVSSDGTTPLAIA 774
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/162 (32%), Positives = 79/162 (48%), Gaps = 2/162 (1%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
T+ + AA+ G + NG D+N N +G + L LA GH+ +V L +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
G TALH AA G V+ ++ G V+ + G+TPL ++A + V L+
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLY-MAAQENHLEVVKFLL 131
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVK 307
+ GAN NV +G TPL VA+ HE +V L++ G V+
Sbjct: 132 ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 74.7 bits (182), Expect = 1e-13
Identities = 65/222 (29%), Positives = 94/222 (42%), Gaps = 35/222 (15%)
Query: 142 KFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKY------ 195
K GFT L VAA+ G R+ ++L+ N +G L +A + +LD+VK
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 196 ---------------------------LRRHGASWQARDLGGCTALHWAADGGHCSVIEW 228
L ++G S A + G T LH AA GH ++
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 229 MIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 288
++ + + SG TPL V A G+ VA +LI G V+ R G TPL VA
Sbjct: 654 LLSKQANGN-LGNKSGLTPLHLV-AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 711
Query: 289 NHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
+ +LV+ LL AD + K + G L A +V+LL
Sbjct: 712 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 70.9 bits (172), Expect = 2e-12
Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 4/162 (2%)
Query: 170 VNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCS-VIEW 228
V + S + A +G+LD R+G + G LH A+ GH V+E
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 229 MIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 288
+ K E+ + T + ++A++G V L++ GANVN + + G TPL +A
Sbjct: 65 LHK---EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 289 NHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
NH E+V+ LL+ GA+ +V E G L +A ++VV+ L
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 55.8 bits (133), Expect = 5e-08
Identities = 48/169 (28%), Positives = 71/169 (42%), Gaps = 12/169 (7%)
Query: 63 YTGYATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEH----LHRAV 118
Y G A V+G+ P L + + G E L+ + ++ LH
Sbjct: 624 YGGSANAESVQGVTP-------LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Query: 119 SVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGK 178
+ +++ G V VD + G+T L VA+ G +LVK L+ + DVN K G
Sbjct: 677 QEGHVPVADVLIKHG-VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 179 DSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIE 227
L A GH D+V L ++GAS G T L A G+ SV +
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Score = 33.1 bits (74), Expect = 0.37
Identities = 29/132 (21%), Positives = 58/132 (43%), Gaps = 2/132 (1%)
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
R+ T+ AA G+ +++G VD+ + +++ G+ ++ L+
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQS 325
+ + G T L +A L +E+V+ L++ GA+ + +++ G L MA +
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 326 VVSLLEERKKKQ 337
VV L E Q
Sbjct: 126 VVKFLLENGANQ 137
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 99.8 bits (247), Expect = 3e-21
Identities = 68/220 (30%), Positives = 107/220 (48%), Gaps = 3/220 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A + ++ +L G V+ + G T L +A+++G +V++L+ G + K
Sbjct: 210 LHIAAHYENLNVAQLLLNRG-ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
L A GH+ + + L HGA QA+ G + +H AA G H + +++
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
E+D + T TPL V+A G+ RVA +L+D GA N + NG TPL +A NH +
Sbjct: 329 AEIDDI-TLDHLTPL-HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
++LLL GA E G L +A +V L +R
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426
Score = 94.7 bits (234), Expect = 1e-19
Identities = 61/190 (32%), Positives = 98/190 (51%), Gaps = 2/190 (1%)
Query: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASW 203
GFT L +A +K + R++++L+ G ++ SG L +A + GHL +VK L + GAS
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 204 QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASL 263
++ T LH AA GH V ++++++ +V+ TPL +A G+ + L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN-AKAKDDQTPL-HCAARIGHTNMVKL 488
Query: 264 LIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDR 323
L++ AN N+ G TPL +A H E V LL+K A + + G L +A + +
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
Query: 324 QSVVSLLEER 333
V LL ER
Sbjct: 549 VRVAELLLER 558
Score = 92.0 bits (227), Expect = 7e-19
Identities = 69/218 (31%), Positives = 105/218 (48%), Gaps = 3/218 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH AV N+ D++ +L G P G+T L +AA++ + + L+ G N +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ G L LA GH ++V L A+ + G T LH A GH V + +IK G
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
VD T G+TPL V++ GN ++ L+ A+VN K + G +PL A H ++
Sbjct: 692 VMVDAT-TRMGYTPL-HVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 294 VQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLE 331
V LLL GA + + G L +A+ SV +L+
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 90.9 bits (224), Expect = 2e-18
Identities = 64/216 (29%), Positives = 104/216 (48%), Gaps = 2/216 (0%)
Query: 125 LLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLA 184
++VR+L +++ K T L AA+ G+ R+ +IL+ +G + K +G + +A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 185 CYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
HLD V+ L ++ A L T LH AA GH V + ++ G + + +G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL-NG 371
Query: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304
+TPL ++ + RV LL+ GA+++ +G TPL VA H +V+ LL +GA
Sbjct: 372 FTPL-HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 305 SVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPK 340
+V N + L MA V L + K K K
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Score = 89.0 bits (219), Expect = 6e-18
Identities = 66/220 (30%), Positives = 106/220 (48%), Gaps = 34/220 (15%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A N ++ +L+ G +D + G T L VA+ G+ +VK L+ G N+
Sbjct: 375 LHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
N + L +A AGH +V KYL ++ A A+ T LH AA GH ++++ ++++
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Query: 234 CEVDVVDTGSGWTPL--------------------------------MRVSAVSGNQRVA 261
++ T +G TPL + V+A G RVA
Sbjct: 494 ANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 262 SLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKG 301
LL++ A+ N +NG TPL VAV +N+ ++V+LLL +G
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 87.8 bits (216), Expect = 1e-17
Identities = 69/224 (30%), Positives = 106/224 (47%), Gaps = 30/224 (13%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A ++V +L + ++ K G TAL +AA G +V+ LV+ G +VN +
Sbjct: 49 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
+ G L +A HL+VVK+L +GA+ G T L A GH +V+ +I G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 234 CEVDV----------------------------VDTGSGWTPLMRVSAVSGNQRVASLLI 265
+ V V + +G+TPL ++A N VA LL+
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPL-HIAAHYENLNVAQLLL 226
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNE 309
+ GA+VN +NG TPL +A + +V+LLLD+GA K +
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 85.9 bits (211), Expect = 5e-17
Identities = 65/207 (31%), Positives = 108/207 (52%), Gaps = 3/207 (1%)
Query: 127 VRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACY 186
VR+L ++D T L VAA G+ R+ K+L+ G N + +G L +AC
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 187 AGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWT 246
H+ V++ L + GAS A G T LH A+ GH +++ +++ G +V + T
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV-KVET 439
Query: 247 PLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV 306
PL ++A +G+ VA L+ A VN K ++ +TPL A H +V+LLL+ A+ ++
Sbjct: 440 PL-HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 307 KNEFGKGVLEM-ARVFDRQSVVSLLEE 332
G L + AR ++V++LLE+
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEK 525
Score = 79.7 bits (195), Expect = 3e-15
Identities = 60/201 (29%), Positives = 100/201 (49%), Gaps = 11/201 (5%)
Query: 85 LKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFG 144
+K+ P G +SP + T LH A N ++ +LQ G + + G
Sbjct: 585 VKLLLPRGGSPHSPAWNGYTP--------LHIAAKQNQVEVARSLLQYGG-SANAESVQG 635
Query: 145 FTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQ 204
T L +AAQ+G+ +V +L+S + NL N SG L L GH+ V L +HG
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 205 ARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLL 264
A G T LH A+ G+ +++++++ +V+ T G++PL + +A G+ + +LL
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ-AAQQGHTDIVTLL 753
Query: 265 IDAGANVNVKDRNGKTPLMVA 285
+ GA+ N +G TPL +A
Sbjct: 754 LKNGASPNEVSSDGTTPLAIA 774
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/162 (32%), Positives = 79/162 (48%), Gaps = 2/162 (1%)
Query: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
T+ + AA+ G + NG D+N N +G + L LA GH+ +V L +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
G TALH AA G V+ ++ G V+ + G+TPL ++A + V L+
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLY-MAAQENHLEVVKFLL 131
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVK 307
+ GAN NV +G TPL VA+ HE +V L++ G V+
Sbjct: 132 ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 74.7 bits (182), Expect = 1e-13
Identities = 65/222 (29%), Positives = 94/222 (42%), Gaps = 35/222 (15%)
Query: 142 KFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKY------ 195
K GFT L VAA+ G R+ ++L+ N +G L +A + +LD+VK
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 196 ---------------------------LRRHGASWQARDLGGCTALHWAADGGHCSVIEW 228
L ++G S A + G T LH AA GH ++
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 229 MIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 288
++ + + SG TPL V A G+ VA +LI G V+ R G TPL VA
Sbjct: 654 LLSKQANGN-LGNKSGLTPLHLV-AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 711
Query: 289 NHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
+ +LV+ LL AD + K + G L A +V+LL
Sbjct: 712 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 70.9 bits (172), Expect = 2e-12
Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 4/162 (2%)
Query: 170 VNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCS-VIEW 228
V + S + A +G+LD R+G + G LH A+ GH V+E
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 229 MIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 288
+ K E+ + T + ++A++G V L++ GANVN + + G TPL +A
Sbjct: 65 LHK---EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 289 NHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
NH E+V+ LL+ GA+ +V E G L +A ++VV+ L
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 55.8 bits (133), Expect = 5e-08
Identities = 48/169 (28%), Positives = 71/169 (42%), Gaps = 12/169 (7%)
Query: 63 YTGYATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEH----LHRAV 118
Y G A V+G+ P L + + G E L+ + ++ LH
Sbjct: 624 YGGSANAESVQGVTP-------LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Query: 119 SVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGK 178
+ +++ G V VD + G+T L VA+ G +LVK L+ + DVN K G
Sbjct: 677 QEGHVPVADVLIKHG-VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 179 DSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIE 227
L A GH D+V L ++GAS G T L A G+ SV +
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Score = 33.1 bits (74), Expect = 0.37
Identities = 29/132 (21%), Positives = 58/132 (43%), Gaps = 2/132 (1%)
Query: 206 RDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI 265
R+ T+ AA G+ +++G VD+ + +++ G+ ++ L+
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 266 DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQS 325
+ + G T L +A L +E+V+ L++ GA+ + +++ G L MA +
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 326 VVSLLEERKKKQ 337
VV L E Q
Sbjct: 126 VVKFLLENGANQ 137
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 98.6 bits (244), Expect = 7e-21
Identities = 59/188 (31%), Positives = 103/188 (54%), Gaps = 3/188 (1%)
Query: 137 VDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYL 196
++V ++ G +AL A G+ V +L++ G +N+ + + L A + GHL+V+K L
Sbjct: 133 LNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLL 192
Query: 197 RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSG 256
GA +D G LH AA G V++++++ G E+D + + + ++ G
Sbjct: 193 VARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEID--EPNAFGNTALHIACYLG 250
Query: 257 NQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL-VQLLLDKGADASVKNEFGKGVL 315
VA L++AGANVN + G TPL VA ++ + L ++LL++ GAD + +++ GK L
Sbjct: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310
Query: 316 EMARVFDR 323
MA + R
Sbjct: 311 HMAAIHGR 318
Score = 94.7 bits (234), Expect = 1e-19
Identities = 72/235 (30%), Positives = 120/235 (51%), Gaps = 4/235 (1%)
Query: 97 SPLVSVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGY 156
+PL+S + LH AV + + +L G ++V +K L AA G+
Sbjct: 127 APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKG-ASLNVCDKKERQPLHWAAFLGH 185
Query: 157 TRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHW 216
++K+LV+ G D+ K+ G L A +G ++VVKYL R GA + G TALH
Sbjct: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245
Query: 217 AADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVA-SLLIDAGANVNVKD 275
A G +V ++ G V+ + G+TPL V+AVS N + LL++ GA+VN +
Sbjct: 246 ACYLGQDAVAIELVNAGANVNQPND-KGFTPL-HVAAVSTNGALCLELLVNNGADVNYQS 303
Query: 276 RNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
+ GK+PL +A ++ Q+L+ G++ ++FG L +A + + ++S L
Sbjct: 304 KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
Score = 81.3 bits (199), Expect = 1e-15
Identities = 57/182 (31%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 144 GFTALMVAAQKGYTRLVKILVSNGTDV--NLKNGSGKDSLMLACYAGHLDVVKYLRRHGA 201
G+TA+ AA G + +++L+ + ++++ L LA Y GH + +K L
Sbjct: 550 GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLV 609
Query: 202 SWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVA 261
+ RD G TAL A + G +E + G + + WTPL +A SG+
Sbjct: 610 NLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPL-HAAAASGHTDSL 668
Query: 262 SLLIDAGANVN---VKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMA 318
LLID+G + V D G+TPLM+A++N H + V LLL+KG+ A + G+ L
Sbjct: 669 HLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRG 728
Query: 319 RV 320
V
Sbjct: 729 AV 730
Score = 77.0 bits (188), Expect = 2e-14
Identities = 68/224 (30%), Positives = 104/224 (46%), Gaps = 22/224 (9%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRL-VKILVSNGTDVNL 172
LH A + + + + ++ G V+ PN GFT L VAA L +++LV+NG DVN
Sbjct: 243 LHIACYLGQDAVAIELVNAG-ANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301
Query: 173 KNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKD 232
++ GK L +A G + L ++G+ D G T LH AA GH +I ++ +
Sbjct: 302 QSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTN 361
Query: 233 GCEVDVVDTG------------SGWTPLMRVSAVSGN--QRVASL----LIDAGANVNVK 274
G D G G++ R SG V+SL ++ AG ++N
Sbjct: 362 G--ADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTP 419
Query: 275 DRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMA 318
D G+T L A + E + LLL GAD +++FG+ L A
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYA 463
Score = 73.2 bits (178), Expect = 3e-13
Identities = 56/205 (27%), Positives = 96/205 (46%), Gaps = 7/205 (3%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVK--VDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVN 171
LH A + D L ++ G DV + +G T LM+A G+ V +L+ G+ +
Sbjct: 656 LHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTAD 715
Query: 172 LKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIK 231
+ G+ +L G D + L H A RD G T +H A+ GH +V+ +++
Sbjct: 716 AADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQ 775
Query: 232 DGCEVDVVDTG---SGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 288
D +D G SG++P M ++ +G++ LL++ + + + N TPL AV+N
Sbjct: 776 AALSTDPLDAGVDYSGYSP-MHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVIN 833
Query: 289 NHEELVQLLLDKGADASVKNEFGKG 313
N + ++LL V + KG
Sbjct: 834 NQDSTTEMLLGALGAKIVNSRDAKG 858
Score = 70.5 bits (171), Expect = 2e-12
Identities = 52/196 (26%), Positives = 92/196 (46%), Gaps = 4/196 (2%)
Query: 138 DVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLR 197
DV + + L +AA G+ +K L ++++++ G+ +L LA G + V+ L
Sbjct: 579 DVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLT 638
Query: 198 RHGASWQARDLGG-CTALHWAADGGHCSVIEWMIKDGCEVDVVDT--GSGWTPLMRVSAV 254
HGAS ++ T LH AA GH + +I G D+ D G TPLM ++ +
Sbjct: 639 AHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLM-LAIM 697
Query: 255 SGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGV 314
+G+ LL++ G+ + D G+T L + E+ + LLD A ++ G+
Sbjct: 698 NGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTP 757
Query: 315 LEMARVFDRQSVVSLL 330
+ +A +V+ L
Sbjct: 758 IHLASACGHTAVLRTL 773
Score = 69.7 bits (169), Expect = 4e-12
Identities = 61/204 (29%), Positives = 98/204 (48%), Gaps = 2/204 (0%)
Query: 127 VRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACY 186
VR L + ++V ++ T L AA G ++++L+ +G +VN K+ L A
Sbjct: 24 VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAA 83
Query: 187 AGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWT 246
+ + V+ L H A ARD T LH AA E + ++V D SG +
Sbjct: 84 SRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADR-SGRS 142
Query: 247 PLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV 306
L + SG+ +LL++ GA++NV D+ + PL A H E+++LL+ +GAD
Sbjct: 143 ALHH-AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGC 201
Query: 307 KNEFGKGVLEMARVFDRQSVVSLL 330
K+ G G+L A + VV L
Sbjct: 202 KDRKGYGLLHTAAASGQIEVVKYL 225
Score = 68.2 bits (165), Expect = 1e-11
Identities = 50/174 (28%), Positives = 86/174 (49%), Gaps = 2/174 (1%)
Query: 160 VKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAAD 219
V+ L+S ++N+ + + L A Y G + +++ L GA+ A+D T LH AA
Sbjct: 24 VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAA 83
Query: 220 GGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGK 279
+ V+ ++ +V+ D W + V+A + + A L +++NV DR+G+
Sbjct: 84 SRNEKVLGLLLAHSADVNARD--KLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGR 141
Query: 280 TPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
+ L AV + H E V LLL+KGA +V ++ + L A V+ LL R
Sbjct: 142 SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVAR 195
Score = 60.5 bits (145), Expect = 2e-09
Identities = 64/273 (23%), Positives = 112/273 (41%), Gaps = 45/273 (16%)
Query: 106 REPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVS 165
R+ +SS L+ VS + +L G ++ P+ G T L AA G + +L+S
Sbjct: 389 RKLLSSGQLYSIVSSLSNE---HVLSAG-FDINTPDNLGRTCLHAAASGGNVECLNLLLS 444
Query: 166 NGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAA------- 218
+G D+ ++ G+ L A G L GA D GC+ LH+AA
Sbjct: 445 SGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRR 504
Query: 219 -----DGGHCS----------------VIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGN 257
H + +E+++ +G + + D G+T + +A GN
Sbjct: 505 AEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDR-QGYT-AVHYAAAYGN 562
Query: 258 QRVASLLIDAGANV--NVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFG---- 311
++ LL++ N +V+ +PL +A N H E ++ L + + V++ G
Sbjct: 563 RQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTAL 622
Query: 312 -----KGVLEMARVFDRQSVVSLLEERKKKQRP 339
+G E V +L++ERK+K P
Sbjct: 623 FLATERGSTECVEVLTAHGASALIKERKRKWTP 655
Score = 48.5 bits (114), Expect = 9e-06
Identities = 50/172 (29%), Positives = 78/172 (45%), Gaps = 19/172 (11%)
Query: 102 VSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVK 161
+ +R+ LH A ++ L +LQ + +V+ + G TALM AA+ G T V+
Sbjct: 850 IVNSRDAKGRTPLHAAAFADNVSGLRMLLQH-QAEVNATDHTGRTALMTAAENGQTAAVE 908
Query: 162 ILVSNG-TDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTA------- 213
L+ G D+ + + + +L LAC GH + + +DLG A
Sbjct: 909 FLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILA-----ETQDLGLINATNSALQM 963
Query: 214 -LHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLL 264
LH AA G SV++ ++ G V VD G TP + A + N+ VA L
Sbjct: 964 PLHIAARNGLASVVQALLSHGATVLAVDE-EGHTPAL---ACAPNKDVADCL 1011
Score = 47.4 bits (111), Expect = 2e-05
Identities = 58/256 (22%), Positives = 96/256 (37%), Gaps = 40/256 (15%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LHR ED L +L + K G T + +A+ G+T +++ L+ +
Sbjct: 725 LHRGAVTGCEDCLAALLDHDAFVLCRDFK-GRTPIHLASACGHTAVLRTLLQAALSTDPL 783
Query: 174 NG----SGKDSLMLACYAGHLDVVKYLRRH------------------------------ 199
+ SG + A Y GH D ++ L H
Sbjct: 784 DAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLL 843
Query: 200 ---GASW-QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVS 255
GA +RD G T LH AA + S + +++ EV+ D +G T LM +
Sbjct: 844 GALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDH-TGRTALMTAAENG 902
Query: 256 GNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVL 315
V LL A++ V D N T L +A HE+ ++L + D + N +
Sbjct: 903 QTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQ 962
Query: 316 EMARVFDRQSVVSLLE 331
+ R + S+++
Sbjct: 963 MPLHIAARNGLASVVQ 978
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 98.6 bits (244), Expect = 7e-21
Identities = 63/175 (36%), Positives = 92/175 (52%), Gaps = 2/175 (1%)
Query: 128 RILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYA 187
R+L V PN+ G L ++G+ ++V +L+++G DVN+ + G+ LM+A
Sbjct: 1051 RLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASE 1110
Query: 188 GHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTP 247
GHL V +L GAS D G TAL WA GH SV+ ++ +G D D +G TP
Sbjct: 1111 GHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADK-NGRTP 1169
Query: 248 LMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGA 302
L ++A G+ V L+D GA + D +G PL AV + +V LL KGA
Sbjct: 1170 L-DLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
Score = 84.0 bits (206), Expect = 2e-16
Identities = 62/197 (31%), Positives = 91/197 (46%), Gaps = 2/197 (1%)
Query: 143 FGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGAS 202
+G TAL AA +G + ++L+ G V N G L GH +V L HGA
Sbjct: 1033 WGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGAD 1092
Query: 203 WQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVAS 262
D G T L AA GH +++++ G + ++D G T L + + G+ V
Sbjct: 1093 VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDK-EGLTAL-SWACLKGHLSVVR 1150
Query: 263 LLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFD 322
L+D GA + D+NG+TPL +A E+VQ L+D GA + G L+ A
Sbjct: 1151 SLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCR 1210
Query: 323 RQSVVSLLEERKKKQRP 339
SVV L ++ K P
Sbjct: 1211 NTSVVVTLLKKGAKIGP 1227
Score = 70.1 bits (170), Expect = 3e-12
Identities = 54/179 (30%), Positives = 84/179 (46%), Gaps = 5/179 (2%)
Query: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
+V +L V++ +K G T LM+AA +G+ V L++ G + L + G +L AC
Sbjct: 1082 IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWAC 1141
Query: 186 YAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGW 245
GHL VV+ L +GA+ D G T L AA G V+++++ G ++ VD SG
Sbjct: 1142 LKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDY-SGM 1200
Query: 246 TPLMRVSAVSGNQRVASLLIDAGANVNVKD---RNGKTPLMVAVLNNHEELVQLLLDKG 301
PL R N V L+ GA + K +M+ +L+ E + KG
Sbjct: 1201 RPLDRAVGCR-NTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKG 1258
Score = 63.5 bits (153), Expect = 3e-10
Identities = 70/268 (26%), Positives = 103/268 (38%), Gaps = 50/268 (18%)
Query: 100 VSVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRL 159
+S ST ++ L + N + + IL G + L V + GYT +
Sbjct: 841 ISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEM 900
Query: 160 VKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAAD 219
V +L+ G +V+ + SG L A AG+L +V L + A D G AL AA
Sbjct: 901 VALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAAL 960
Query: 220 GGHCSVIEWMI--------------------------------------------KDGCE 235
GH V++++I KD E
Sbjct: 961 RGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEE 1020
Query: 236 VDVVDTGS-----GWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNH 290
V+ S G T L +A G V LL++ GA V +R G PL V H
Sbjct: 1021 VERAQINSFDSLWGETAL-TAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGH 1079
Query: 291 EELVQLLLDKGADASVKNEFGKGVLEMA 318
++V LLL GAD ++ ++ G+ L MA
Sbjct: 1080 WQIVDLLLTHGADVNMADKQGRTPLMMA 1107
Score = 37.4 bits (85), Expect = 0.020
Identities = 25/84 (29%), Positives = 40/84 (47%)
Query: 247 PLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASV 306
P++ V + G + +LL++ GANV+ +G TPL A + +V LL K A
Sbjct: 887 PILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDH 946
Query: 307 KNEFGKGVLEMARVFDRQSVVSLL 330
++ G+ L A + VV L
Sbjct: 947 LDKNGQCALVHAALRGHLEVVKFL 970
Score = 37.0 bits (84), Expect = 0.026
Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 257 NQRVASLLIDAGANVNVKDR--NGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGV 314
N +V+ LLI GAN+N + N L V + E+V LLL+ GA+ +E G
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
Query: 315 LEMARVFDRQSVVSLLEERKKK 336
L A S+V LL +++ K
Sbjct: 922 LGYAAAAGYLSIVVLLCKKRAK 943
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 95.9 bits (237), Expect = 5e-20
Identities = 68/183 (37%), Positives = 97/183 (53%), Gaps = 3/183 (1%)
Query: 148 LMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARD 207
L+VAA KG T V L++ G V + G+ L LA GHL VV+ L + G +D
Sbjct: 14 LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
Query: 208 LGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDA 267
G TALH A G+ +I +I +GC +D D G T L S G + A LL+ A
Sbjct: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDK-DGNTALHEASW-HGFSQSAKLLVKA 130
Query: 268 GANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVV 327
GANV K++ G T L +A N+H + ++LL G+ A +KN G L +A ++ S++
Sbjct: 131 GANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSII 190
Query: 328 SLL 330
LL
Sbjct: 191 RLL 193
Score = 90.5 bits (223), Expect = 2e-18
Identities = 57/184 (30%), Positives = 96/184 (52%), Gaps = 3/184 (1%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LHRA V + +++ ++ G +D +K G TAL A+ G+++ K+LV G +V K
Sbjct: 79 LHRATVVGNTEIIAALIHEG-CALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAK 137
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
N +G +L LAC H + L G+ ++ G T LH AA H S+I ++
Sbjct: 138 NKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAF 197
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
C V + + V+A +++VA +L++AGA+ + + G+TPL A +N+ E+
Sbjct: 198 CSVH--EKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEV 255
Query: 294 VQLL 297
LL
Sbjct: 256 ALLL 259
Score = 85.1 bits (209), Expect = 8e-17
Identities = 66/224 (29%), Positives = 109/224 (48%), Gaps = 5/224 (2%)
Query: 109 ISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGT 168
+S L A E+++ I +G RV V K G T L +AA KG+ +V+IL+ G
Sbjct: 10 LSERLLVAAYKGQTENVVQLINKGARVAV---TKHGRTPLHLAANKGHLPVVQILLKAGC 66
Query: 169 DVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEW 228
D+++++ + +L A G+ +++ L G + +D G TALH A+ G +
Sbjct: 67 DLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKL 126
Query: 229 MIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 288
++K G V + +G T L S +Q LL+ AG+ ++K+ G T L VA
Sbjct: 127 LVKAGANV-LAKNKAGNTALHLACQNSHSQSTRVLLL-AGSRADLKNNAGDTCLHVAARY 184
Query: 289 NHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEE 332
NH +++LLL KN+ G L +A + + V +L E
Sbjct: 185 NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLE 228
>gi|42734375 ankyrin repeat and sterile alpha motif domain
containing 3 [Homo sapiens]
Length = 656
Score = 95.5 bits (236), Expect = 6e-20
Identities = 52/184 (28%), Positives = 97/184 (52%), Gaps = 1/184 (0%)
Query: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
LH A S+ +++ +Q + ++ N G+T LM A+ G+ +V +L+ G VN+
Sbjct: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
Query: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233
G+ LMLA G+ + +L + GA + +D+ G TAL GH ++ +++ G
Sbjct: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSG 158
Query: 234 CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL 293
+V + G+TPLM +A +G++ + ++ G V+ +D +G T M+A H ++
Sbjct: 159 ANANVREPICGFTPLME-AAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKI 217
Query: 294 VQLL 297
V L+
Sbjct: 218 VALM 221
Score = 89.7 bits (221), Expect = 3e-18
Identities = 61/186 (32%), Positives = 94/186 (50%), Gaps = 4/186 (2%)
Query: 148 LMVAAQKGYTRLVKILVSNGT-DVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQAR 206
L AA G +VK V D+N KNG G LM A Y GH +V L G S
Sbjct: 39 LHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVP 98
Query: 207 DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLID 266
G T L A+ G+ S+ ++++ G E+++ D GWT L ++ +G+Q + L+D
Sbjct: 99 TPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDI-QGWTALFHCTS-AGHQHMVRFLLD 156
Query: 267 AGANVNVKDRN-GKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQS 325
+GAN NV++ G TPLM A HE +VQ L+ G ++ G +A+ +
Sbjct: 157 SGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMK 216
Query: 326 VVSLLE 331
+V+L++
Sbjct: 217 IVALMD 222
Score = 67.4 bits (163), Expect = 2e-11
Identities = 47/142 (33%), Positives = 75/142 (52%), Gaps = 3/142 (2%)
Query: 167 GTDVNLKNGSGKDSLMLACYAGHLDVVKY-LRRHGASWQARDLGGCTALHWAADGGHCSV 225
GT V+ + L A G +VVK ++R ++ GG T L +A+ GH ++
Sbjct: 25 GTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTI 84
Query: 226 IEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVA 285
+ +++ G V+V T G TPLM S+ GN+ +A L+ GA + +KD G T L
Sbjct: 85 VHLLLEAGVSVNV-PTPEGQTPLMLASSC-GNESIAYFLLQQGAELEMKDIQGWTALFHC 142
Query: 286 VLNNHEELVQLLLDKGADASVK 307
H+ +V+ LLD GA+A+V+
Sbjct: 143 TSAGHQHMVRFLLDSGANANVR 164
Score = 39.3 bits (90), Expect = 0.005
Identities = 20/59 (33%), Positives = 34/59 (57%)
Query: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGAS 202
GFT LM AA G+ +V+ +++G V+ ++ SG + MLA GH+ +V + + S
Sbjct: 169 GFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPS 227
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,112,179
Number of Sequences: 37866
Number of extensions: 646509
Number of successful extensions: 5730
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 393
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 1569
Number of HSP's gapped (non-prelim): 2069
length of query: 345
length of database: 18,247,518
effective HSP length: 103
effective length of query: 242
effective length of database: 14,347,320
effective search space: 3472051440
effective search space used: 3472051440
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.