Guide to the Human Genome
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Search of human proteins with 148539846

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
sapiens]
         (896 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap...  1818   0.0  
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap...  1681   0.0  
gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo sapi...  1237   0.0  
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi...  1132   0.0  
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi...   895   0.0  
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]   808   0.0  
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]           418   e-116
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]           410   e-114
gi|29789445 desmoglein 4 isoform 2 [Homo sapiens]                     351   2e-96
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]           347   2e-95
gi|4826669 cadherin 15 preproprotein [Homo sapiens]                   344   2e-94
gi|197313787 desmoglein 4 isoform 1 [Homo sapiens]                    343   5e-94
gi|4502719 cadherin 13 preproprotein [Homo sapiens]                   342   1e-93
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]            339   6e-93
gi|116534898 desmoglein 2 preproprotein [Homo sapiens]                337   2e-92
gi|119964718 desmoglein 3 preproprotein [Homo sapiens]                317   4e-86
gi|29570800 cadherin-like 26 isoform a [Homo sapiens]                 289   9e-78
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]           269   1e-71
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]           261   2e-69
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]           261   2e-69
gi|119703744 desmoglein 1 preproprotein [Homo sapiens]                253   6e-67
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]          250   4e-66
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]            247   3e-65
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]          247   4e-65
gi|221316595 cadherin 17 precursor [Homo sapiens]                     246   5e-65
gi|221316593 cadherin 17 precursor [Homo sapiens]                     246   5e-65
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]          245   2e-64
gi|16753221 cadherin 22 precursor [Homo sapiens]                      234   3e-61
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]           229   7e-60
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]           226   6e-59

>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
           sapiens]
          Length = 896

 Score = 1818 bits (4708), Expect = 0.0
 Identities = 896/896 (100%), Positives = 896/896 (100%)

Query: 1   MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRS 60
           MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRS
Sbjct: 1   MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRS 60

Query: 61  ADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVS 120
           ADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVS
Sbjct: 61  ADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVS 120

Query: 121 KTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDK 180
           KTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDK
Sbjct: 121 KTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDK 180

Query: 181 EPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNH 240
           EPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNH
Sbjct: 181 EPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNH 240

Query: 241 PVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPS 300
           PVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPS
Sbjct: 241 PVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPS 300

Query: 301 TGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAY 360
           TGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAY
Sbjct: 301 TGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAY 360

Query: 361 EAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVV 420
           EAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVV
Sbjct: 361 EAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVV 420

Query: 421 KPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRI 480
           KPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRI
Sbjct: 421 KPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRI 480

Query: 481 KENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETP 540
           KENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETP
Sbjct: 481 KENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETP 540

Query: 541 KNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPD 600
           KNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPD
Sbjct: 541 KNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPD 600

Query: 601 EPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAA 660
           EPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAA
Sbjct: 601 EPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAA 660

Query: 661 TKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKG 720
           TKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKG
Sbjct: 661 TKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKG 720

Query: 721 KRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIE 780
           KRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIE
Sbjct: 721 KRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIE 780

Query: 781 MMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNE 840
           MMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNE
Sbjct: 781 MMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNE 840

Query: 841 DRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR 896
           DRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR
Sbjct: 841 DRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR 896


>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
           sapiens]
          Length = 839

 Score = 1681 bits (4353), Expect = 0.0
 Identities = 831/832 (99%), Positives = 832/832 (100%)

Query: 1   MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRS 60
           MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRS
Sbjct: 1   MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRS 60

Query: 61  ADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVS 120
           ADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVS
Sbjct: 61  ADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVS 120

Query: 121 KTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDK 180
           KTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDK
Sbjct: 121 KTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDK 180

Query: 181 EPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNH 240
           EPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNH
Sbjct: 181 EPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNH 240

Query: 241 PVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPS 300
           PVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPS
Sbjct: 241 PVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPS 300

Query: 301 TGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAY 360
           TGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAY
Sbjct: 301 TGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAY 360

Query: 361 EAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVV 420
           EAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVV
Sbjct: 361 EAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVV 420

Query: 421 KPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRI 480
           KPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRI
Sbjct: 421 KPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRI 480

Query: 481 KENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETP 540
           KENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETP
Sbjct: 481 KENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETP 540

Query: 541 KNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPD 600
           KNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPD
Sbjct: 541 KNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPD 600

Query: 601 EPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAA 660
           EPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAA
Sbjct: 601 EPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAA 660

Query: 661 TKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKG 720
           TKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKG
Sbjct: 661 TKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKG 720

Query: 721 KRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIE 780
           KRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIE
Sbjct: 721 KRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIE 780

Query: 781 MMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEK 832
           MMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGE+
Sbjct: 781 MMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEE 832


>gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo
           sapiens]
          Length = 901

 Score = 1237 bits (3201), Expect = 0.0
 Identities = 603/901 (66%), Positives = 720/901 (79%), Gaps = 5/901 (0%)

Query: 1   MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRS 60
           M AA P  S  GA+C  LLLTL I   A +ACK V L+VPSKL+A+K++GRVNL+ECF +
Sbjct: 1   MEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTA 60

Query: 61  ADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVS 120
           A+LI SSDPDF++L DGSVYT   + LS +KRSFTI LS+   Q +K++ V LEHQ KV 
Sbjct: 61  ANLIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVL 120

Query: 121 KTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDK 180
           K RHT+E VLRRAKRRWAPIPCSM ENSLGPFPLFLQQV+SD AQNYT++YSI G GVD+
Sbjct: 121 KKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQ 180

Query: 181 EPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNH 240
           EP NLFY+ERDTGNL+CTRPVDRE+Y+ F++IA+A+T DGY+ +LPLPL I++EDENDN+
Sbjct: 181 EPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNY 240

Query: 241 PVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPS 300
           P+FTE  Y F + E+ R GTTVG VCATD+DEPDTMHTRLKYSI+ Q P SP LFS+HP+
Sbjct: 241 PIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPT 300

Query: 301 TGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAY 360
           TGVITT S  LDRE++DKY L +KVQDMDGQ+FGL  TSTCII + D ND+ PTF + +Y
Sbjct: 301 TGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSY 360

Query: 361 EAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVV 420
              VEEN  +VEILR+ +EDKDL+NTANWR N+TILKGNENG+FKI TD +TNEGVL VV
Sbjct: 361 VTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVV 420

Query: 421 KPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRI 480
           KPLNYEE +Q+ L+IGV NEAPF+R+    +A++ A VTV+V D DEGPEC P  Q VR+
Sbjct: 421 KPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRM 480

Query: 481 KENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETP 540
           KEN  VG+  NGYKAYDPE R+ +G+RYKKL DP GW+TIDE +GSI   + LDRE ET 
Sbjct: 481 KENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETI 540

Query: 541 KNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPD 600
           KN +YNITVLA D+  R+CTGTL + ++DVNDN P I ++ V+ICKP M   +I+AVDPD
Sbjct: 541 KNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPD 600

Query: 601 EPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAA 660
           EP+HG PF FSL +++ E+ R+W L  +NDTAARLSYQ +  F  Y +PITV+DR G ++
Sbjct: 601 EPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSS 660

Query: 661 TKLLRVNLCECTHPTQC--RATSR--STGVILGKWAILAILLGIALLFSVLLTLVCGVFG 716
              L V LC+C     C  R   R    GV LGKWAILAILLGIALLF +L TLVCG  G
Sbjct: 661 VTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASG 720

Query: 717 ATK-GKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGG 775
            +K  K  P+DLAQQNLI+SNTEAPGDD+V SANGF TQT   S+QG CGT+GSG+KNGG
Sbjct: 721 TSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGG 780

Query: 776 QETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHR 835
           QETIEM+KGG+QT ESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEK++ 
Sbjct: 781 QETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKVYL 840

Query: 836 CNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTK 895
           CNQ+E+   +QDYVLTYNYEGRGS AGSVGCCSE+QEEDGL+FL+NLEPKF TLAEAC K
Sbjct: 841 CNQDENHKHAQDYVLTYNYEGRGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAEACMK 900

Query: 896 R 896
           R
Sbjct: 901 R 901


>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
           sapiens]
          Length = 847

 Score = 1132 bits (2929), Expect = 0.0
 Identities = 553/837 (66%), Positives = 663/837 (79%), Gaps = 5/837 (0%)

Query: 1   MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRS 60
           M AA P  S  GA+C  LLLTL I   A +ACK V L+VPSKL+A+K++GRVNL+ECF +
Sbjct: 1   MEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTA 60

Query: 61  ADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVS 120
           A+LI SSDPDF++L DGSVYT   + LS +KRSFTI LS+   Q +K++ V LEHQ KV 
Sbjct: 61  ANLIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVL 120

Query: 121 KTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDK 180
           K RHT+E VLRRAKRRWAPIPCSM ENSLGPFPLFLQQV+SD AQNYT++YSI G GVD+
Sbjct: 121 KKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQ 180

Query: 181 EPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNH 240
           EP NLFY+ERDTGNL+CTRPVDRE+Y+ F++IA+A+T DGY+ +LPLPL I++EDENDN+
Sbjct: 181 EPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNY 240

Query: 241 PVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPS 300
           P+FTE  Y F + E+ R GTTVG VCATD+DEPDTMHTRLKYSI+ Q P SP LFS+HP+
Sbjct: 241 PIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPT 300

Query: 301 TGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAY 360
           TGVITT S  LDRE++DKY L +KVQDMDGQ+FGL  TSTCII + D ND+ PTF + +Y
Sbjct: 301 TGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSY 360

Query: 361 EAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVV 420
              VEEN  +VEILR+ +EDKDL+NTANWR N+TILKGNENG+FKI TD +TNEGVL VV
Sbjct: 361 VTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVV 420

Query: 421 KPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRI 480
           KPLNYEE +Q+ L+IGV NEAPF+R+    +A++ A VTV+V D DEGPEC P  Q VR+
Sbjct: 421 KPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRM 480

Query: 481 KENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETP 540
           KEN  VG+  NGYKAYDPE R+ +G+RYKKL DP GW+TIDE +GSI   + LDRE ET 
Sbjct: 481 KENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETI 540

Query: 541 KNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPD 600
           KN +YNITVLA D+  R+CTGTL + ++DVNDN P I ++ V+ICKP M   +I+AVDPD
Sbjct: 541 KNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPD 600

Query: 601 EPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAA 660
           EP+HG PF FSL +++ E+ R+W L  +NDTAARLSYQ +  F  Y +PITV+DR G ++
Sbjct: 601 EPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSS 660

Query: 661 TKLLRVNLCECTHPTQC--RATSR--STGVILGKWAILAILLGIALLFSVLLTLVCGVFG 716
              L V LC+C     C  R   R    GV LGKWAILAILLGIALLF +L TLVCG  G
Sbjct: 661 VTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASG 720

Query: 717 ATK-GKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGG 775
            +K  K  P+DLAQQNLI+SNTEAPGDD+V SANGF TQT   S+QG CGT+GSG+KNGG
Sbjct: 721 TSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGG 780

Query: 776 QETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEK 832
           QETIEM+KGG+QT ESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGE+
Sbjct: 781 QETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEE 837


>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
           sapiens]
          Length = 894

 Score =  895 bits (2313), Expect = 0.0
 Identities = 460/892 (51%), Positives = 623/892 (69%), Gaps = 20/892 (2%)

Query: 15  CLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVL 74
           C  LL +L++ +   +AC+KV L VPS L+A+ ++G+VNLEEC +SA LIRSSDP FR+L
Sbjct: 13  CKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSASLIRSSDPAFRIL 72

Query: 75  NDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLE-HQKKVSKTRHTRETVLRRA 133
            DGS+YT   + LS +++SF+I+LSD +++ Q+E+ V+L   + K  K RHT++T L+R+
Sbjct: 73  EDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPKKRHTKDTALKRS 132

Query: 134 KRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTG 193
           KRRWAPIP S+ ENSLGPFP  +QQ++SDAAQNYT+FYSISG GVDKEP NLFYIE+DTG
Sbjct: 133 KRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYIEKDTG 192

Query: 194 NLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVL 253
           ++FCTR +DRE+Y+ F L  YA+TADGY+ + PLPL I++ED+NDN P F   +  F V 
Sbjct: 193 DIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVP 252

Query: 254 ESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDR 313
           E+ R GT+VG V ATD DEPDT+HTRLKY ILQQ P  P  FS+HP TGVITT + +LDR
Sbjct: 253 ENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTTTPFLDR 312

Query: 314 EVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEI 373
           E  D Y LIM+V+DM GQ FGL  T T  I++ D NDN P+F + +Y   VEEN  +VEI
Sbjct: 313 EKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENRIDVEI 372

Query: 374 LRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNL 433
           LR+ ++D+DL NT + +  + IL+GNENG+F ISTD  TNEGVL VVKPLNYE NRQV L
Sbjct: 373 LRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVNRQVIL 432

Query: 434 EIGVNNEAPFARDIPRVT-ALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKING 492
           ++GV NEA F++     T  +    VTV + D DEGPEC P  + ++ ++    G ++ G
Sbjct: 433 QVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLG 492

Query: 493 YKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAI 552
           YKA DPE  +G GLRY+KL D   W  I++ +G + T K+LDRE +  KN  YNI+V+A+
Sbjct: 493 YKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVVAV 552

Query: 553 DKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSL 612
           D   RSCTGTL V+++D ND+ P+I +E V IC+    +  +  VDPD P +G PF F L
Sbjct: 553 DAVGRSCTGTLVVHLDDYNDHAPQIDKE-VTICQNNEDFAVLKPVDPDGPENGPPFQFFL 611

Query: 613 PNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECT 672
            N++   S+ W++ + +   A L  ++N  +  Y++PI +KDR G  AT +L V +C+C+
Sbjct: 612 DNSA---SKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCS 668

Query: 673 HPTQCRATSRST-----GVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDL 727
            P++CR   +ST      VILG+WAILA++LG  LL  +L T  C     T  K FPED+
Sbjct: 669 TPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPEDI 728

Query: 728 AQQNLIISNTEAPGDDRVCSANGFMTQTTNN---SSQGFCGTMGSGMKNGGQETIEMMKG 784
           AQQNLI+SNTE PG++ V  AN  +   T+N   +S       G G+K   Q++ EM+KG
Sbjct: 729 AQQNLIVSNTEGPGEE-VTEANIRLPMQTSNICDTSMSVGTVGGQGIKT--QQSFEMVKG 785

Query: 785 GNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMP 844
           G  TL+S +G G H TL+S + G  + D  RY Y++W SFTQPRLGEK++ C Q+E+   
Sbjct: 786 G-YTLDSNKGGG-HQTLESVK-GVGQGDTGRYAYTDWQSFTQPRLGEKVYLCGQDEEHKH 842

Query: 845 SQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR 896
            +DYV +YNYEG+GS AGSVGCCS++QEE+GL+FL++LEPKF TLA+ C K+
Sbjct: 843 CEDYVCSYNYEGKGSLAGSVGCCSDRQEEEGLEFLDHLEPKFRTLAKTCIKK 894


>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
          Length = 840

 Score =  808 bits (2087), Expect = 0.0
 Identities = 421/828 (50%), Positives = 570/828 (68%), Gaps = 20/828 (2%)

Query: 15  CLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVL 74
           C  LL +L++ +   +AC+KV L VPS L+A+ ++G+VNLEEC +SA LIRSSDP FR+L
Sbjct: 13  CKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSASLIRSSDPAFRIL 72

Query: 75  NDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLE-HQKKVSKTRHTRETVLRRA 133
            DGS+YT   + LS +++SF+I+LSD +++ Q+E+ V+L   + K  K RHT++T L+R+
Sbjct: 73  EDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPKKRHTKDTALKRS 132

Query: 134 KRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTG 193
           KRRWAPIP S+ ENSLGPFP  +QQ++SDAAQNYT+FYSISG GVDKEP NLFYIE+DTG
Sbjct: 133 KRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYIEKDTG 192

Query: 194 NLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVL 253
           ++FCTR +DRE+Y+ F L  YA+TADGY+ + PLPL I++ED+NDN P F   +  F V 
Sbjct: 193 DIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVP 252

Query: 254 ESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDR 313
           E+ R GT+VG V ATD DEPDT+HTRLKY ILQQ P  P  FS+HP TGVITT + +LDR
Sbjct: 253 ENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTTTPFLDR 312

Query: 314 EVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEI 373
           E  D Y LIM+V+DM GQ FGL  T T  I++ D NDN P+F + +Y   VEEN  +VEI
Sbjct: 313 EKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENRIDVEI 372

Query: 374 LRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNL 433
           LR+ ++D+DL NT + +  + IL+GNENG+F ISTD  TNEGVL VVKPLNYE NRQV L
Sbjct: 373 LRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVNRQVIL 432

Query: 434 EIGVNNEAPFARDIPRVT-ALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKING 492
           ++GV NEA F++     T  +    VTV + D DEGPEC P  + ++ ++    G ++ G
Sbjct: 433 QVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLG 492

Query: 493 YKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAI 552
           YKA DPE  +G GLRY+KL D   W  I++ +G + T K+LDRE +  KN  YNI+V+A+
Sbjct: 493 YKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVVAV 552

Query: 553 DKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSL 612
           D   RSCTGTL V+++D ND+ P+I +E V IC+    +  +  VDPD P +G PF F L
Sbjct: 553 DAVGRSCTGTLVVHLDDYNDHAPQIDKE-VTICQNNEDFAVLKPVDPDGPENGPPFQFFL 611

Query: 613 PNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECT 672
            N++   S+ W++ + +   A L  ++N  +  Y++PI +KDR G  AT +L V +C+C+
Sbjct: 612 DNSA---SKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCS 668

Query: 673 HPTQCRATSRST-----GVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDL 727
            P++CR   +ST      VILG+WAILA++LG  LL  +L T  C     T  K FPED+
Sbjct: 669 TPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPEDI 728

Query: 728 AQQNLIISNTEAPGDDRVCSANGFMTQTTNN---SSQGFCGTMGSGMKNGGQETIEMMKG 784
           AQQNLI+SNTE PG++ V  AN  +   T+N   +S       G G+K   Q++ EM+KG
Sbjct: 729 AQQNLIVSNTEGPGEE-VTEANIRLPMQTSNICDTSMSVGTVGGQGIKT--QQSFEMVKG 785

Query: 785 GNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEK 832
           G  TL+S +G G H TL+S + G  + D  RY Y++W SFTQPRLGE+
Sbjct: 786 G-YTLDSNKGGG-HQTLESVK-GVGQGDTGRYAYTDWQSFTQPRLGEE 830


>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
          Length = 906

 Score =  418 bits (1074), Expect = e-116
 Identities = 279/854 (32%), Positives = 429/854 (50%), Gaps = 55/854 (6%)

Query: 66  SSDP-DFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLE-----HQKKV 119
           SS+P DF+V  DG VY  R+  LS +   F I+  DK  Q + +V V L       ++ V
Sbjct: 73  SSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVKLSLKPTLTEESV 132

Query: 120 SKTRHTRETV-----------LRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYT 168
            ++    E V           L+R KR W   P ++ ENS GPFP  L ++ SD  +N +
Sbjct: 133 KESAEVEEIVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLS 192

Query: 169 VFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLP 228
           + YS++G G D+ P  +F I   +G L  T+P+DRE+   F L A+A   +G   + P+ 
Sbjct: 193 LRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPID 252

Query: 229 LPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQT 288
           + I V D NDN P F   ++N  V E S+PGT V  V A D D+P+ ++  L+Y I+ Q 
Sbjct: 253 IVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQA 312

Query: 289 PR--SPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQ-FFGLIGTSTCIITV 345
           P   SP +F+++  TG I TV+  LDRE V +Y+LI++  DM+G   +GL  T+T +ITV
Sbjct: 313 PSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITV 372

Query: 346 TDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFK 405
           TD NDN P F    +   V EN  ++ +  + + DKD  +T  W   + I  G+  G F 
Sbjct: 373 TDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFA 432

Query: 406 ISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDL 465
           I TD  +N+G+++VVKP+++E NR   L +   N+ P A+ I      + A V+V V D+
Sbjct: 433 IQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQ-STATVSVTVIDV 491

Query: 466 DEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISG 525
           +E P   P  + +R +E L  G+ +  + A DP+      +RY KL DP  W+ ID ++G
Sbjct: 492 NENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNG 551

Query: 526 SIITSKILDREVETPKNELYNITVLAIDKD--DRSCTGTLAVNIEDVNDNPPEILQEYVV 583
            I T  +LDRE    KN +YN T LA D      S TGTL + + D+NDN P++L +   
Sbjct: 552 QITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAE 611

Query: 584 ICK-PKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQ---K 639
            C+ P     +I A+D D   +  PF F LP +   I R W++T++N   A+L+ +    
Sbjct: 612 TCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFL 671

Query: 640 NAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLG 699
            AG  E  I IT      ++   +LRV +C+C     C    R  G  LG  AI+AILL 
Sbjct: 672 EAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLC 731

Query: 700 IALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNS 759
           I +L  ++L  V  +      KR  ++   + L+I     P DD   +   +  +     
Sbjct: 732 IIILLILVLMFVVWM------KRRDKERQAKQLLID----PEDDVRDNILKYDEE----- 776

Query: 760 SQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYS 819
                   G G ++   +  ++ +      ++ +  G     +  R  H E      + +
Sbjct: 777 --------GGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRMDE--RPIHAEPQYPVRSAA 826

Query: 820 EWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQE--EDGLD 877
                    + E L +   N+   P  D +L ++YEG GS AGS+   +      E   D
Sbjct: 827 PHPGDIGDFINEGL-KAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYD 885

Query: 878 FLNNLEPKFITLAE 891
           +LN+  P+F  LA+
Sbjct: 886 YLNDWGPRFKKLAD 899


>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
          Length = 916

 Score =  410 bits (1053), Expect = e-114
 Identities = 276/896 (30%), Positives = 447/896 (49%), Gaps = 83/896 (9%)

Query: 43  LEADKIIGRVNLEECFRSADL-IRSSDPDFRVLNDGSVYTARAVALSDKKRSFTI--WLS 99
           LE +K++ +V    C  +      ++  DF+V  DG+V+  R + +  ++ +FT+  W S
Sbjct: 49  LEGEKLL-QVKFSSCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDS 107

Query: 100 DKRKQTQKEVTVLLE--------HQKKVSKT------------------RHTRETVLRRA 133
              ++    V +L+         H+ +  K                   +H     LRR 
Sbjct: 108 QTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRR 167

Query: 134 KRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTG 193
           KR W   P ++ ENS GPFP  L ++ SD   +  + YSI+G G D+ P+ +F I+  +G
Sbjct: 168 KRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSG 227

Query: 194 NLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVL 253
            ++ TRP+DREE+  + L A+A   +G   + P+ L I V D NDN P F   +YN  V 
Sbjct: 228 RMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVD 287

Query: 254 ESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSP--GLFSVHPSTGVITTVSHYL 311
           E S+PGT V  V A D D+  T +  ++Y I+ QTP+SP   +F+++  TG I TV+  L
Sbjct: 288 EGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGL 347

Query: 312 DREVVDKYSLIMKVQDMDGQF-FGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFN 370
           DRE V +Y++I++  DM+G   +GL  T+T IITVTD NDN P F  + +   V EN   
Sbjct: 348 DREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVE 407

Query: 371 VEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQ 430
             +  + + D+D  ++ NW   + I+ G+ +GHF + TD  TNEG+++VVK ++YE NR 
Sbjct: 408 TVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRA 467

Query: 431 VNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKI 490
             L + V+N+AP A  I +++  + A VT+ + D++E P      + +R++E +  G+ +
Sbjct: 468 FMLTVMVSNQAPLASGI-QMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVL 526

Query: 491 NGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVL 550
             + A DP+      +RY KL DP  W+ I+  +G I T+ +LDRE    KN +Y  T L
Sbjct: 527 TTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFL 586

Query: 551 AIDK--DDRSCTGTLAVNIEDVNDNPPEILQEYVVIC-KPKMGYTDILAVDPDEPVHGAP 607
           A D      S TGTL + + D+NDN PE+L +   IC KP +   +I A D D   +  P
Sbjct: 587 AADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGP 646

Query: 608 FYFSLPNTSPEISRLWSLTKVNDTAARLSYQ---KNAGFQEYTIPITVKDRAGQ--AATK 662
           + F LP     + + W++T++N   A+LS +     AG   Y +PI V D      + T 
Sbjct: 647 YVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGM--YDVPIIVTDSGNPPLSNTS 704

Query: 663 LLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKR 722
           +++V +C C     C          LG  AI+AIL+ I +L +++L  V  +    K + 
Sbjct: 705 IIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERH 764

Query: 723 F------PEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQ 776
                  PED  + N++  + E  G++     +  ++Q     + G   +   G++   +
Sbjct: 765 TKQLLIDPEDDVRDNILKYDEEGGGEE---DQDYDLSQLQQPEAMGHVPSKAPGVRRVDE 821

Query: 777 ETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRC 836
             +              GA   + +        ++ +               + E L R 
Sbjct: 822 RPV--------------GAEPQYPIRPMVPHPGDIGDF--------------INEGL-RA 852

Query: 837 NQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEED-GLDFLNNLEPKFITLAE 891
             N+   P  D +L ++YEG GS AGSV   +     D   D+LN+  P+F  LA+
Sbjct: 853 ADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLAD 908


>gi|29789445 desmoglein 4 isoform 2 [Homo sapiens]
          Length = 1040

 Score =  351 bits (901), Expect = 2e-96
 Identities = 248/825 (30%), Positives = 388/825 (47%), Gaps = 72/825 (8%)

Query: 125 TRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLN 184
           T+   +RR KR W     + +E         + ++ SD   N  + Y ISG G+D+ P  
Sbjct: 39  TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98

Query: 185 LFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFT 244
           +F I   TG +  T  VDRE   +F +   A  + G   + PL L ++V D NDN PVF+
Sbjct: 99  VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158

Query: 245 EAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVI 304
           +++Y   + E+S   T V  +CATD DE + +++++ Y I+ Q P    +F ++  TG +
Sbjct: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218

Query: 305 TTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFV 364
            T+S +LDRE    Y+L+++  D DG   GL     C I V D NDN PT  + +Y A +
Sbjct: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278

Query: 365 EENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLN 424
           EEN  + E++R+   D D   T NW   + IL GN+   F I TD +TNEG+L VVK L+
Sbjct: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338

Query: 425 YEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENL 484
           YE+   + L IGV N+A F   +     ++   V + V D+ EGP   P+     ++E +
Sbjct: 339 YEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398

Query: 485 AVGSKIN----GYKAYDPENRN-GNGLRYKKLHDPKGWITIDEISGSIITSKILDREVET 539
              S +N     Y A D +  N    +RY   HD   W+ ID  +G I  S+  D++ + 
Sbjct: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKY 458

Query: 540 PKNELYNITVLAIDK-DDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVD 598
             N +Y   +LAID    ++ TGT+ + + D+ND  P I  E   IC      +  + + 
Sbjct: 459 IINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICID----SPSVLIS 514

Query: 599 PDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQ 658
            +E  +G+PF F + +  P I+ +W +   N T+A L+ ++      Y IPI VKD   +
Sbjct: 515 VNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNR 574

Query: 659 AA--TKLLRVNLCECTHPTQCRATSRS----------------------TGVILGKWAIL 694
           A    +++++  C+C     C  +  +                      + V LG   I 
Sbjct: 575 ACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIG 634

Query: 695 AILLGIALL-FSVLLTLVC-------------------GVFGATKGKRF----PEDLAQQ 730
            ++LGI LL  + LL L+C                   G  G  +  R     PED    
Sbjct: 635 MMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVS 694

Query: 731 NLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLE 790
           N+    T +   DR+ S+  +    TN  + G       G   GG   +E +  G  T  
Sbjct: 695 NICAPMTASNTQDRMDSSEIY----TNTYAAG-------GTVEGGVSGVE-LNTGMGTAV 742

Query: 791 SCRGAGHHHTLDSCRGGHTEVDNCR-YTYSEWH-SFTQPRLGEKLHRCNQNEDRMPSQDY 848
               AG      + R   + +   R Y  ++ + +F      EK +     ++  P+ D 
Sbjct: 743 GLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDC 802

Query: 849 VLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEAC 893
           +L Y++EG GSP GS+GCCS   ++     +  L+PKF TLAE C
Sbjct: 803 LLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEIC 847


>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
          Length = 829

 Score =  347 bits (891), Expect = 2e-95
 Identities = 213/621 (34%), Positives = 325/621 (52%), Gaps = 18/621 (2%)

Query: 129 VLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYI 188
           +LRR KR W   P S+ EN  GPFP  L Q++S+  ++  +FYSI+G G D  P  +F +
Sbjct: 101 ILRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAV 160

Query: 189 ERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIY 248
           E++TG L   +P+DREE   ++L  +A + +G S + P+ + I V D+ND+ P FT+  +
Sbjct: 161 EKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTF 220

Query: 249 NFEVLESSRPGTTVGVVCATDRDEP-DTMHTRLKYSILQQTPRSPG--LFSVHPSTGVIT 305
              VLE   PGT+V  V ATD D+   T +  + YSI  Q P+ P   +F++H STG I+
Sbjct: 221 RGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTIS 280

Query: 306 TVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVE 365
            +S  LDRE V +Y+L ++  DMDG   G   T+  ++ + D+NDNAP F    YEA V 
Sbjct: 281 VISSGLDREKVPEYTLTIQATDMDGD--GSTTTAVAVVEILDANDNAPMFDPQKYEAHVP 338

Query: 366 ENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNY 425
           ENA   E+ R+ + D D  N+  WR  + I+ G++  HF I+T  E+N+G+L+  K L++
Sbjct: 339 ENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDF 398

Query: 426 EENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLA 485
           E   Q  L + V NEAPF   +P  T    A + VHV D++E P   P ++ V ++E + 
Sbjct: 399 EAKNQHTLYVEVTNEAPFVLKLPTST----ATIVVHVEDVNEAPVFVPPSKVVEVQEGIP 454

Query: 486 VGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVET-PKNEL 544
            G  +  Y A DP+  N   + Y+ L DP GW+ +D  SG +     LDRE E   +N +
Sbjct: 455 TGEPVCVYTAEDPDKEN-QKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNI 513

Query: 545 YNITVLAIDKDD--RSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEP 602
           Y + VLA+D      + TGTL + + DVND+ P      + IC        +   D D  
Sbjct: 514 YEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITDKDLS 573

Query: 603 VHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATK 662
            H +PF   L + S +I     + +  DT   LS +K      Y + +++ D   +    
Sbjct: 574 PHTSPFQAQLTDDS-DIYWTAEVNEEGDTVV-LSLKKFLKQDTYDVHLSLSDHGNKEQLT 631

Query: 663 LLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKR 722
           ++R  +C+C    +        G IL    +L  +L +  L  VLL LV       +   
Sbjct: 632 VIRATVCDCHGHVETCPGPWKGGFIL---PVLGAVLALLFLLLVLLLLVRKKRKIKEPLL 688

Query: 723 FPEDLAQQNLIISNTEAPGDD 743
            PED  + N+     E  G++
Sbjct: 689 LPEDDTRDNVFYYGEEGGGEE 709



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 2/50 (4%)

Query: 844 PSQDYVLTYNYEGRGSPAGSVG--CCSEKQEEDGLDFLNNLEPKFITLAE 891
           P  D +L ++YEG GS A S+     S   ++   D+LN    +F  LA+
Sbjct: 772 PPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLAD 821


>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
          Length = 814

 Score =  344 bits (883), Expect = 2e-94
 Identities = 235/637 (36%), Positives = 334/637 (52%), Gaps = 29/637 (4%)

Query: 126 RETVLRRAKRRWAPIPCSMQENSLG-PFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLN 184
           R   L R +R W   P S+ EN    P+PL   Q++SD  Q  +V YSI G GVD+EP  
Sbjct: 36  RAPALSRVRRAWVIPPISVSENHKRLPYPLV--QIKSDKQQLGSVIYSIQGPGVDEEPRG 93

Query: 185 LFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFT 244
           +F I++ TG +F    +DRE+ D F L A+A    G + + P  L I V D+NDN P F 
Sbjct: 94  VFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFL 153

Query: 245 EAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVI 304
           +  +   VLE + PGT V    ATD D+P+T +  L++SILQQ   SP LFS+   TG I
Sbjct: 154 QEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ--GSPELFSIDELTGEI 211

Query: 305 TTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFV 364
            TV   LDREVV  Y+L ++V DM G   GL  T++ IIT+ D NDNAP F ++ +    
Sbjct: 212 RTVQVGLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEA 269

Query: 365 EENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLN 424
            E    V++ R+ +ED+DL  + NW   FTIL+G+ +G F I TD +TNEGVLS+VK L+
Sbjct: 270 IEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALD 329

Query: 425 YEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENL 484
           YE      L++ V NEAP      R     +A V VHV+D +E P          + E  
Sbjct: 330 YESCEHYELKVSVQNEAPLQAAALRAER-GQAKVRVHVQDTNEPPVFQENPLRTSLAEGA 388

Query: 485 AVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNEL 544
             G+ +  + A DP+      L Y K +DP+ W+ +D  +G I T  +L       K   
Sbjct: 389 PPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGW 448

Query: 545 YNITVLAID--KDDRSCTGTLAVNIEDVNDNPPEIL--QEYVVICKPKMGYTDIL-AVDP 599
           Y   VLA D     R+ TGTL++ I +VND+ P +       +  +P  G   +L A D 
Sbjct: 449 YRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDE 508

Query: 600 DEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARL--SYQKNAGFQEYTIPITVKDRAG 657
           D P HGAPF+F L    PE+ R WSL++VN + ARL   +Q   G    ++ +    +  
Sbjct: 509 DLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPP 568

Query: 658 QAATKLLRVNLCECTH-----PTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLV- 711
           Q   + L V +C C       P      +  TG+ LG    L I+L  ALL  VL+ LV 
Sbjct: 569 QQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLG---ALVIVLASALLLLVLVLLVA 625

Query: 712 --CGVFGATKGKRF---PEDLAQQNLIISNTEAPGDD 743
                +  ++GK     P+D  + N++  + +  G++
Sbjct: 626 LRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEE 662



 Score = 37.4 bits (85), Expect = 0.063
 Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 2/55 (3%)

Query: 839 NEDRMPSQDYVLTYNYEGRGSPAGSVG--CCSEKQEEDGLDFLNNLEPKFITLAE 891
           ++  +P  D  L Y+YEG GS AG++     S+  E+   D+L +  P+F  LA+
Sbjct: 724 SDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLAD 778


>gi|197313787 desmoglein 4 isoform 1 [Homo sapiens]
          Length = 1059

 Score =  343 bits (879), Expect = 5e-94
 Identities = 248/838 (29%), Positives = 387/838 (46%), Gaps = 79/838 (9%)

Query: 125 TRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLN 184
           T+   +RR KR W     + +E         + ++ SD   N  + Y ISG G+D+ P  
Sbjct: 39  TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98

Query: 185 LFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFT 244
           +F I   TG +  T  VDRE   +F +   A  + G   + PL L ++V D NDN PVF+
Sbjct: 99  VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158

Query: 245 EAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVI 304
           +++Y   + E+S   T V  +CATD DE + +++++ Y I+ Q P    +F ++  TG +
Sbjct: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218

Query: 305 TTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFV 364
            T+S +LDRE    Y+L+++  D DG   GL     C I V D NDN PT  + +Y A +
Sbjct: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278

Query: 365 EENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLN 424
           EEN  + E++R+   D D   T NW   + IL GN+   F I TD +TNEG+L VVK L+
Sbjct: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338

Query: 425 YEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENL 484
           YE+   + L IGV N+A F   +     ++   V + V D+ EGP   P+     ++E +
Sbjct: 339 YEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398

Query: 485 AVGSKIN----GYKAYDPENRN-GNGLRYKKLHDPKGWITIDEISGSIITSKILDREVET 539
              S +N     Y A D +  N    +RY   HD   W+ ID  +G I  S+  D++ + 
Sbjct: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKY 458

Query: 540 PKNELYNITVLAIDK-DDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVD 598
             N +Y   +LAID    ++ TGT+ + + D+ND  P I  E   IC      +  + + 
Sbjct: 459 IINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICID----SPSVLIS 514

Query: 599 PDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQ 658
            +E  +G+PF F + +  P I+ +W +   N T+A L+ ++      Y IPI VKD   +
Sbjct: 515 VNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNR 574

Query: 659 AA--TKLLRVNLCECTHPTQCRATSRS----------------------TGVILGKWAIL 694
           A    +++++  C+C     C  +  +                      + V LG   I 
Sbjct: 575 ACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIG 634

Query: 695 AILLGIALL-FSVLLTLVCGVFGATKGKRFPEDLAQQNLIISN-----------TEAPGD 742
            ++LGI LL  + LL L+C        +R PE L  +   +               A  +
Sbjct: 635 MMVLGILLLILAPLLLLLC-----CCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPE 689

Query: 743 DRVCSA----NGFMTQTTNNSSQGFCGTMGS---------------------GMKNGGQE 777
           DR+ SA     G  T     S  G C    +                     G   GG  
Sbjct: 690 DRLFSAYALPGGGGTADGGGSVLGRCALQATPALLNQHPPFSEIYTNTYAAGGTVEGGVS 749

Query: 778 TIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCR-YTYSEWH-SFTQPRLGEKLHR 835
            +E +  G  T      AG      + R   + +   R Y  ++ + +F      EK + 
Sbjct: 750 GVE-LNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYA 808

Query: 836 CNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEAC 893
               ++  P+ D +L Y++EG GSP GS+GCCS   ++     +  L+PKF TLAE C
Sbjct: 809 YADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEIC 866


>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
          Length = 713

 Score =  342 bits (876), Expect = 1e-93
 Identities = 224/655 (34%), Positives = 346/655 (52%), Gaps = 30/655 (4%)

Query: 37  LNVPSKLEADKIIGRVNLEECFRSADLIRS--SDPDFRVLNDGSVYTARAVALSDKKRSF 94
           +N P++   D+ I  +   +C +  D +R   S P F+V +DG +   R +    K    
Sbjct: 38  INQPAEFIEDQSILNLTFSDC-KGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGK---- 92

Query: 95  TIWLSDKRKQTQKEVTVLLEHQKKVSKT-----RHTRETVLRRAKRRWAPIPCSMQENSL 149
           T+++  +    +    +++   K +  +     +  R + + R KR     P  + EN  
Sbjct: 93  TLFVHARTPHAEDMAELVIVGGKDIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQR 152

Query: 150 GPFPLFLQQV-ESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDV 208
            PFP  + +V +SD  +     + ++G+GVD+EP  +F I  +TG++  TR +DRE   V
Sbjct: 153 QPFPRDVGKVVDSDRPERSK--FRLTGKGVDQEPKGIFRINENTGSVSVTRTLDREVIAV 210

Query: 209 FDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCAT 268
           + L    +  +G + + P+PL + V D+NDN P+F E  Y   V+E S  GTTV  + A 
Sbjct: 211 YQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAF 270

Query: 269 DRDEPDTMHTRLKYSILQQTPR--SPGLFSVHPSTGVITTVSH--YLDREVVD--KYSLI 322
           D D+P T +  L+Y+I QQTP   SP +F + P  G I TV     LDRE ++  KY LI
Sbjct: 271 DADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELI 330

Query: 323 MKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKD 382
           ++ QDM G   GL GT+T  I + D ND++P F +  ++A VEE A  V I+ + +EDKD
Sbjct: 331 IEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQATVEEGAVGV-IVNLTVEDKD 389

Query: 383 LINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAP 442
              T  WR  +TI+ GN    F+I T+ +TNEG+LSVVKPL+YE +    L I V NE P
Sbjct: 390 DPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENEDP 449

Query: 443 FARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRN 502
              D+    + + A V + V D++EGP   P    V  +E+L+VGS +    A DP++  
Sbjct: 450 LVPDVSYGPS-STATVHITVLDVNEGPVFYPDPMMVTRQEDLSVGSVLLTVNATDPDSLQ 508

Query: 503 GNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGT 562
              +RY    DP GW+ I+ I+G++ T+ +LDRE     N +Y    LAID  +   TGT
Sbjct: 509 HQTIRYSVYKDPAGWLNINPINGTVDTTAVLDRESPFVDNSVYTALFLAIDSGNPPATGT 568

Query: 563 --LAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGA--PFYFSLPNTSPE 618
             L + +EDVNDN P I      +C      + ++    D+ +H    PF F +   +  
Sbjct: 569 GTLLITLEDVNDNAPFIYPTVAEVCDDAKNLSVVILGASDKDLHPNTDPFKFEIHKQAVP 628

Query: 619 ISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKL--LRVNLCEC 671
             ++W ++K+N+T A +S  +N     Y +PI V D      T +  LRV +C C
Sbjct: 629 -DKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSC 682


>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
          Length = 882

 Score =  339 bits (870), Expect = 6e-93
 Identities = 238/728 (32%), Positives = 364/728 (50%), Gaps = 37/728 (5%)

Query: 43  LEADKIIGRVNLEECF-RSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTI--WLS 99
           LE  +++GRVN E+C  R      S D  F+V  DG +   R +   + +  F +  W S
Sbjct: 46  LERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDS 105

Query: 100 DKRKQTQKEVTVLL-------EHQKKVSKTRHTRETV------LRRAKRRWAPIPCSMQE 146
             RK + K     +        HQ  VS  +    T       LRR KR W   P S  E
Sbjct: 106 TYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPE 165

Query: 147 NSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEY 206
           N  GPFP  L Q++S+  +   VFYSI+G+G D  P+ +F IER+TG L  T P+DRE  
Sbjct: 166 NEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERI 225

Query: 207 DVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVC 266
             + L ++A +++G + + P+ + I V D+NDN P FT+ ++   V+E + PGT+V  V 
Sbjct: 226 ATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVT 285

Query: 267 ATDRDEP-DTMHTRLKYSILQQTPRSP--GLFSVHPSTGVITTVSHYLDREVVDKYSLIM 323
           ATD D+  +T +  + Y+IL Q P  P   +F+++ +TGVI+ V+  LDRE    Y+L++
Sbjct: 286 ATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVV 345

Query: 324 KVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDL 383
           +  D+ G+  GL  T+T +ITVTD+NDN P F    Y+  V EN  NV I  + + D D 
Sbjct: 346 QAADLQGE--GLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADA 403

Query: 384 INTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPF 443
            NT  W   +TIL  ++ G F ++T+   N+G+L   K L++E  +Q  L + V N  PF
Sbjct: 404 PNTPAWEAVYTIL-NDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPF 462

Query: 444 ARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNG 503
              +   T    A VTV V D++E P   P  + V + E+  VG +I  Y A +P+    
Sbjct: 463 EVSLTTST----ATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFME 518

Query: 504 NGLRYKKLHDPKGWITIDEISGSIITSKILDRE-VETPKNELYNITVLAIDKDD--RSCT 560
             + Y+   D   W+ I+  +G+I T   LDRE  E  KN  Y   ++A D      + T
Sbjct: 519 QKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGT 578

Query: 561 GTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEIS 620
           GTL + + DVNDN P      +  C+       I  +D D P + +PF   L + +   S
Sbjct: 579 GTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGA---S 635

Query: 621 RLWSLTKVNDTAARLSYQKNAGFQ--EYTIPITVKDRAGQAATKLLRVNLCECTHPTQCR 678
             W++   + T   +  +     +  +Y I + + D   +     L V++C+C       
Sbjct: 636 ANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVC 695

Query: 679 ATSRSTGVILGKWAILAILLGI-ALLFSVLLTLVCGVFGATKGKRF--PEDLAQQNLIIS 735
             ++     L   AIL IL GI ALL  +LL L+     A   +    PED  + N+   
Sbjct: 696 RKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYY 755

Query: 736 NTEAPGDD 743
           + E  G++
Sbjct: 756 DEEGGGEE 763



 Score = 33.5 bits (75), Expect = 0.91
 Identities = 18/50 (36%), Positives = 27/50 (54%), Gaps = 2/50 (4%)

Query: 844 PSQDYVLTYNYEGRGSPAGSVGC--CSEKQEEDGLDFLNNLEPKFITLAE 891
           P  D +L ++YEG GS A S+     SE  ++   D+LN    +F  LA+
Sbjct: 825 PPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLAD 874


>gi|116534898 desmoglein 2 preproprotein [Homo sapiens]
          Length = 1118

 Score =  337 bits (865), Expect = 2e-92
 Identities = 236/798 (29%), Positives = 379/798 (47%), Gaps = 35/798 (4%)

Query: 130 LRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQN--YTVFYSISGRGVDKEPLNLFY 187
           L R KR W   P +++E         + ++ SD A+     + Y  +G+G+ + P  +F 
Sbjct: 44  LVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFV 103

Query: 188 IERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAI 247
             +DTG L  T  +DREE   F L  YA  A G + + PL L I+V D NDN PVFT+ +
Sbjct: 104 FNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDV 163

Query: 248 YNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTV 307
           +   V E S   T V  + ATD DEP+T+++++ Y I+   P  P +F ++  TG I T 
Sbjct: 164 FVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTT 223

Query: 308 SHYLDREVVDKYSLIMKVQDMDGQFFGL-IGTSTCIITVTDSNDNAPTFRQNAYEAFVEE 366
           S  LDRE    Y+L ++ +D +G+     +  +   I + D NDN P       E  VEE
Sbjct: 224 SVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEE 283

Query: 367 NAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYE 426
           N  NVE+ RI + D D I + NW  NFT   GNE G+F I TD +TNEG+++++K ++YE
Sbjct: 284 NQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYE 343

Query: 427 ENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAV 486
           E + ++  + V N+A F + I          + V V+++ EG     +   + + E++  
Sbjct: 344 EMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDR 403

Query: 487 GSK---INGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNE 543
            SK   I  ++A+D +       RY KL D   WI++D ++  I  +K+ D E    +N 
Sbjct: 404 SSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNG 463

Query: 544 LYNITVLAIDKD--DRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDE 601
            Y + ++AI +D   ++ TGT+ +N+ED+NDN P +++    IC     Y ++ A D D 
Sbjct: 464 TYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICH-DAEYVNVTAEDLDG 522

Query: 602 PVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSY-QKNAGFQEYTIPITVKDRAGQAA 660
             +  PF FS+ +  P ++  W + +   T+  L   +K  G  E    I+         
Sbjct: 523 HPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPE 582

Query: 661 TKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSV-LLTLVCGVFGATK 719
            ++L + +CEC H + CR     + V LG  AI  ++L   LL  V LL L+C      K
Sbjct: 583 KQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAK 642

Query: 720 GKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETI 779
           G        +     +N  AP +D+V  +   + Q  +   +   G M       G  + 
Sbjct: 643 GFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSA 702

Query: 780 EMMKGGNQTLESCRGAGHHHTLDSCR--------GGHTEVDNCRYTYSEWHS-------- 823
            ++KG ++  E       H +L S R        G     +  +   +   S        
Sbjct: 703 SIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQA 762

Query: 824 --------FTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDG 875
                   F +    +K     + ++   ++D +L Y+ E   S   S+GCCS  + E  
Sbjct: 763 AAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIEGELD 822

Query: 876 LDFLNNLEPKFITLAEAC 893
             FL++L  KF TLAE C
Sbjct: 823 DRFLDDLGLKFKTLAEVC 840


>gi|119964718 desmoglein 3 preproprotein [Homo sapiens]
          Length = 999

 Score =  317 bits (811), Expect = 4e-86
 Identities = 246/861 (28%), Positives = 392/861 (45%), Gaps = 111/861 (12%)

Query: 113 LEHQKKVSKTRHTRETVLRRAKRRWAPI--PCSMQENSLGPFPLFLQQVESDAAQNYTVF 170
           +E + +  +   T +   RR KR W     PC   E++    P+   ++ SD      + 
Sbjct: 27  IETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDNSKRNPI--AKITSDYQATQKIT 84

Query: 171 YSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLP 230
           Y ISG G+D+ P  +F ++++TG++  T  VDREE   F +   A  A G   + PL L 
Sbjct: 85  YRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILT 144

Query: 231 IRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPR 290
           +++ D NDN PVF++ I+  E+ E+S   + V ++ ATD DEP+ +++++ + I+ Q P 
Sbjct: 145 VKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPA 204

Query: 291 SPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSND 350
              +F +  +TG + T+++ LDRE    Y L++   D DG+  GL     C I V D ND
Sbjct: 205 GTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVND 262

Query: 351 NAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDK 410
           N P FR + Y A +EEN  + E+LR  + D D   T NW   +    GNE   F+I TD 
Sbjct: 263 NFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDP 322

Query: 411 ETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPE 470
            TNEG+L VVK L+YE+ + V L I V N+A F + +     +    VT+ V ++ EG  
Sbjct: 323 RTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIA 382

Query: 471 CTPAAQYVRIKENLA----VGSKINGYKAYDPE-NRNGNGLRYKKLHDPKGWITIDEISG 525
             PA++   +++ ++    V   +  Y+A D + N+  + ++Y    +  G++ ID  + 
Sbjct: 383 FRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTA 442

Query: 526 SIITSKILDREVETPKNELYNITVLAIDK-DDRSCTGTLAVNIEDVNDNPPEILQEYVVI 584
            I   K ++R+     N+     VLAID+   ++ TGT+ V + D NDN P  + E   +
Sbjct: 443 EIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAV 502

Query: 585 CKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQ 644
           C        +++       +  P+ F+L +   ++  +WS+T +N T+A L  Q+     
Sbjct: 503 CSSSPSV--VVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPG 560

Query: 645 EYTIPITVKDRAGQAA--TKLLRVNLCEC--------THPTQCRAT--SRSTGVILGKWA 692
            Y I + + D         + L + +C+C        ++PT    T   R     LG  A
Sbjct: 561 VYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAA 620

Query: 693 ILAILLGIALLF---SVLLTLVCGVFGATKG----------------------KRFPEDL 727
           I  +LLG+ LL     +LLT  CG  G+T G                         PED 
Sbjct: 621 IGLLLLGLLLLLLAPLLLLTCDCGA-GSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDK 679

Query: 728 AQQNLIISNTEAPGDD-----RVCS-----------------------------ANGFMT 753
              N+ +    A G D      VC+                             A GF T
Sbjct: 680 EITNICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFAT 739

Query: 754 QTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDN 813
            T + ++ GF    G G+ + GQ       G  +T  S  G    +   +          
Sbjct: 740 GTVSGAASGFGAATGVGICSSGQ------SGTMRTRHSTGGTNKDYADGAIS-------- 785

Query: 814 CRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEG---RGSPAGSVGCCSEK 870
                    +F      +K   C + +D   + D +L Y+ EG    GSP GSVGCCS  
Sbjct: 786 --------MNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFI 837

Query: 871 QEEDGLDFLNNLEPKFITLAE 891
            ++    FL++L PKF  LAE
Sbjct: 838 ADDLDDSFLDSLGPKFKKLAE 858


>gi|29570800 cadherin-like 26 isoform a [Homo sapiens]
          Length = 832

 Score =  289 bits (739), Expect = 9e-78
 Identities = 199/642 (30%), Positives = 321/642 (50%), Gaps = 32/642 (4%)

Query: 122 TRHTRETV---LRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGV 178
           T+ T+E +   LRR+KRRW      ++E   GPFP  + ++ ++ + N ++ Y ISG GV
Sbjct: 38  TKQTKEKIYQPLRRSKRRWVITTLELEEEDPGPFPKLIGELFNNMSYNMSLMYLISGPGV 97

Query: 179 DKEP-LNLFYIE-RDTGNLFCTRPVDRE---EYDVFDLIAYASTADGYSADLPLPLPIRV 233
           D+ P + LF +E  + G ++  RPVDRE    + V+  +   ST  G   D  L   IR+
Sbjct: 98  DEYPEIGLFSLEDHENGRIYVHRPVDREMTPSFTVYFDVVERST--GKIVDTSLIFNIRI 155

Query: 234 EDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTP--RS 291
            D ND+ P F E  +N  V E+   G  +  + A D DE +T ++++ Y ++ QTP  + 
Sbjct: 156 SDVNDHAPQFPEKEFNITVQENQSAGQPIFQMLAVDLDEENTPNSQVLYFLISQTPLLKE 215

Query: 292 PGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDN 351
            G F V   +G I  +S  LD E   +++L+++ +D       L  T+T  + V + N++
Sbjct: 216 SG-FRVDRLSGEIR-LSGCLDYETAPQFTLLIRARDCGEP--SLSSTTTVHVDVQEGNNH 271

Query: 352 APTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKE 411
            P F Q  Y+  + E   +  +LR+ ++D+D   T+ WR  F IL GNE GHF ISTD E
Sbjct: 272 RPAFTQENYKVQIPEGRASQGVLRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPE 331

Query: 412 TNEGVLSVVKPLNYEENRQVNLEIGVNNEAPF-----ARDIPRVTALNRALVTVHVRDLD 466
           TNEG+L+V+KPL+YE     +L I V NE         +  P   A   A V+V V D +
Sbjct: 332 TNEGILNVIKPLDYETRPAQSLIIVVENEERLVFCERGKLQPPRKAAASATVSVQVTDAN 391

Query: 467 EGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGS 526
           + P   P +  V  +E    G+ +  + A DP+++    +RY+ +HDP  W+++D+ SG 
Sbjct: 392 DPPAFHPQSFIVNKEEGARPGTLLGTFNAMDPDSQ----IRYELVHDPANWVSVDKNSGV 447

Query: 527 IITSKILDREVETPKNELYNITVLAIDK--DDRSCTGTLAVNIEDVNDNPPEI--LQEYV 582
           +IT + +DRE     N  Y I + A+D     ++ TGTL + + D+NDN P +     Y+
Sbjct: 448 VITVEPIDRESPHVNNSFYVIIIHAVDDGFPPQTATGTLMLFLSDINDNVPTLRPRSRYM 507

Query: 583 VICKPKMGY-TDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNA 641
            +C+  +     I A DPD      PF F L NT       W L +    +  L   ++ 
Sbjct: 508 EVCESAVHEPLHIEAEDPDLEPFSDPFTFELDNTWGNAEDTWKLGRNWGQSVELLTLRSL 567

Query: 642 GFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQC-RATSRSTGVILGK-WAILAILLG 699
               Y +P+ + D+ G +  + + V +C C     C        G+ +G  + + A  + 
Sbjct: 568 PRGNYLVPLFIGDKQGLSQKQTVHVRICPCASGLTCVELADAEVGLHVGALFPVCAAFVA 627

Query: 700 IALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPG 741
           +A+    LL     +     G     D   Q L++ N E+ G
Sbjct: 628 LAVALLFLLRCYFVLEPKRHGCSVSNDEGHQTLVMYNAESKG 669


>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
          Length = 790

 Score =  269 bits (687), Expect = 1e-71
 Identities = 238/798 (29%), Positives = 379/798 (47%), Gaps = 80/798 (10%)

Query: 120 SKTRHTR-ET-VLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSISGR 176
           ++T+H   ET V  R KR W      + E  +GP P ++ ++ S++ + + +V Y ++G 
Sbjct: 36  NQTKHIEGETEVHHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGE 95

Query: 177 GVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRVED 235
           G       +F I+  TG++  T+ +DRE+   + L A A         +      I+V+D
Sbjct: 96  GAG----TIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQD 151

Query: 236 ENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPRSPGL 294
            NDN P FT+  Y   V E S  GT+V  V ATD D+P   ++ R+ YSILQ  P     
Sbjct: 152 INDNAPKFTDGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQP----Y 207

Query: 295 FSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPT 354
           FSV P TGVI T  H +DRE  + YS++++ +DM GQ  GL G++T  IT+TD NDN P 
Sbjct: 208 FSVDPKTGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPR 267

Query: 355 FRQNAYEAFVEENA-FNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETN 413
           F Q  Y+ +V E+A     + +I   D D  + A+  + ++I+ G+  G F ISTDKET 
Sbjct: 268 FPQKHYQLYVPESAQVGSAVGKIKANDADTGSNAD--MTYSIINGDGMGIFSISTDKETR 325

Query: 414 EGVLSVVKPLNYEENRQVNLEI-GVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECT 472
           EG+LS+ KPLNYE+ +   L I G N    F R        +  ++ + V D+DE P  +
Sbjct: 326 EGILSLKKPLNYEKKKSYTLNIEGANTHLDF-RFSHLGPFKDATMLKIIVGDVDEPPLFS 384

Query: 473 PAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRY---KKLHDPKGWITIDEISGSIIT 529
             +  + + EN  +G+ +    A DP++ N + +RY     + D + +  ID  +G+I T
Sbjct: 385 MPSYLMEVYENAKIGTVVGTVLAQDPDSTN-SLVRYFINYNVEDDR-FFNIDANTGTIRT 442

Query: 530 SKILDREVETPKNELYNITVLA--IDKDDRSCTGTLAVNIEDVNDNPPEILQEY-VVIC- 585
           +K+LDRE ETP    YNITV A  ID  D     T+ + + DVNDNPPE+ +EY +++C 
Sbjct: 443 TKVLDRE-ETP---WYNITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCE 498

Query: 586 --KPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAG- 642
             KP      I A D D+  +G  F F L    P           ++TA+ L+ ++    
Sbjct: 499 NSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRFSR 558

Query: 643 --FQEYTIPITVKDRA--GQAATKLLRVNLCECTHPTQ---CRATSRSTGVILGKWAILA 695
                Y +PI + D      +++  L + +C C    +   C A +  +   L   A++A
Sbjct: 559 TVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIA 618

Query: 696 ILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQT 755
           ILL + +L ++++  +       +     E+  ++N++  + E  G++       F    
Sbjct: 619 ILLCVLILLAIVVLFITLRRSKKEPLIISEEDVRENVVTYDDEGGGEE---DTEAFDITA 675

Query: 756 TNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCR 815
             N S                   E +K         +    H T  +            
Sbjct: 676 LRNPS-----------------AAEELKYRRDIRPEVKLTPRHQTSSTLES--------- 709

Query: 816 YTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGC--CSEKQEE 873
               +   F + RL E        +  +P  D + TY YEG+ S AGS+     +  Q +
Sbjct: 710 ---IDVQEFIKQRLAEA-----DLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSD 761

Query: 874 DGLDFLNNLEPKFITLAE 891
               +L +  P+F  LAE
Sbjct: 762 QDYHYLGDWGPEFKKLAE 779


>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
          Length = 785

 Score =  261 bits (668), Expect = 2e-69
 Identities = 200/602 (33%), Positives = 307/602 (50%), Gaps = 39/602 (6%)

Query: 132 RAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSISGRGVDKEPLNLFYIER 190
           R KR W      + E  +G  PL++ ++ SD  + + ++ Y +SG G      ++F I+ 
Sbjct: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99

Query: 191 DTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRVEDENDNHPVFTEAIYN 249
           +TG++  T+ +DREE   + L A A         +      I+++D NDN P F +  Y 
Sbjct: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159

Query: 250 FEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPRSPGLFSVHPSTGVITTVS 308
             V E S  GT+V  V ATD D+P   ++ R+ YSILQ  P     FSV P TGVI T  
Sbjct: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP----YFSVEPKTGVIKTAL 215

Query: 309 HYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENA 368
             +DRE  D+Y L+++ +DM GQ  GL GT++  +T+TD NDN P F + +Y+  V E+ 
Sbjct: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275

Query: 369 FNVEIL-RIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEE 427
               ++ RI   D D+   AN  + + I+ G+  G FKIS DKET EG++++ K L++E 
Sbjct: 276 PVASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333

Query: 428 NRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVG 487
                L I   N+    R +      +   V + V D+DE P  +     + + E   VG
Sbjct: 334 KTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVG 393

Query: 488 SKINGYKAYDPENRNGNGLRYK--KLHDPKGWITIDEISGSIITSKILDREVETPKNELY 545
           + I    A+DP++ N + +RY   +  D + +  ID  SG I T+K LDRE     N ++
Sbjct: 394 NIIGTVAAHDPDSSN-SPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET----NAIH 448

Query: 546 NITVLAIDKDDRSCTGT--LAVNIEDVNDNPPEILQEY-VVIC---KPKMGYTDILAVDP 599
           NITVLA++  + S  G   +A+ I D+NDN PE   +Y   +C   +P      I AVD 
Sbjct: 449 NITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDK 508

Query: 600 DEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQE-----YTIPITVKD 654
           DEP +G  FYFSL  T    +  +SL    D  A +  ++N GF+      Y +PI + D
Sbjct: 509 DEPSNGHQFYFSL-TTDATNNHNFSLKDNKDNTASILTRRN-GFRRQEQSVYYLPIFIVD 566

Query: 655 RAGQ--AATKLLRVNLCECTH---PTQCRATSRSTGVILGKWAILAILLGIALLFSVLLT 709
                 ++T  L + +C+C        C A +      L   A++AIL  +  L  ++L 
Sbjct: 567 SGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILL 626

Query: 710 LV 711
           +V
Sbjct: 627 IV 628


>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
          Length = 785

 Score =  261 bits (668), Expect = 2e-69
 Identities = 200/602 (33%), Positives = 307/602 (50%), Gaps = 39/602 (6%)

Query: 132 RAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSISGRGVDKEPLNLFYIER 190
           R KR W      + E  +G  PL++ ++ SD  + + ++ Y +SG G      ++F I+ 
Sbjct: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99

Query: 191 DTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRVEDENDNHPVFTEAIYN 249
           +TG++  T+ +DREE   + L A A         +      I+++D NDN P F +  Y 
Sbjct: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159

Query: 250 FEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPRSPGLFSVHPSTGVITTVS 308
             V E S  GT+V  V ATD D+P   ++ R+ YSILQ  P     FSV P TGVI T  
Sbjct: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP----YFSVEPKTGVIKTAL 215

Query: 309 HYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENA 368
             +DRE  D+Y L+++ +DM GQ  GL GT++  +T+TD NDN P F + +Y+  V E+ 
Sbjct: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275

Query: 369 FNVEIL-RIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEE 427
               ++ RI   D D+   AN  + + I+ G+  G FKIS DKET EG++++ K L++E 
Sbjct: 276 PVASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333

Query: 428 NRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVG 487
                L I   N+    R +      +   V + V D+DE P  +     + + E   VG
Sbjct: 334 KTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVG 393

Query: 488 SKINGYKAYDPENRNGNGLRYK--KLHDPKGWITIDEISGSIITSKILDREVETPKNELY 545
           + I    A+DP++ N + +RY   +  D + +  ID  SG I T+K LDRE     N ++
Sbjct: 394 NIIGTVAAHDPDSSN-SPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET----NAIH 448

Query: 546 NITVLAIDKDDRSCTGT--LAVNIEDVNDNPPEILQEY-VVIC---KPKMGYTDILAVDP 599
           NITVLA++  + S  G   +A+ I D+NDN PE   +Y   +C   +P      I AVD 
Sbjct: 449 NITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDK 508

Query: 600 DEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQE-----YTIPITVKD 654
           DEP +G  FYFSL  T    +  +SL    D  A +  ++N GF+      Y +PI + D
Sbjct: 509 DEPSNGHQFYFSL-TTDATNNHNFSLKDNKDNTASILTRRN-GFRRQEQSVYYLPIFIVD 566

Query: 655 RAGQ--AATKLLRVNLCECTH---PTQCRATSRSTGVILGKWAILAILLGIALLFSVLLT 709
                 ++T  L + +C+C        C A +      L   A++AIL  +  L  ++L 
Sbjct: 567 SGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILL 626

Query: 710 LV 711
           +V
Sbjct: 627 IV 628


>gi|119703744 desmoglein 1 preproprotein [Homo sapiens]
          Length = 1049

 Score =  253 bits (646), Expect = 6e-67
 Identities = 144/446 (32%), Positives = 235/446 (52%), Gaps = 2/446 (0%)

Query: 130 LRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIE 189
           +RR KR W     + +E         + ++ SD A N  V Y ISG G+D+ P  +F I 
Sbjct: 44  IRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVIN 103

Query: 190 RDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYN 249
           + TG +  T  VDRE    F +   A  + G   + PL L +RV D NDN PVF+ A + 
Sbjct: 104 QKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFA 163

Query: 250 FEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSH 309
            ++ E+S   T V ++ ATD DEP+ +++++ + I++Q P    +F ++ +TG I T+++
Sbjct: 164 GQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNN 223

Query: 310 YLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAF 369
           +LDRE   +Y+L ++  D DG   G+     C I + D NDN P   Q++Y   ++EN  
Sbjct: 224 FLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTL 283

Query: 370 NVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENR 429
           N  +L I + D D   +ANW      + GNE   F+I  ++ TN G+L VVKPL+YE  +
Sbjct: 284 NSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQ 343

Query: 430 QVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSK 489
            + L IGV N+A F   I     L  + ++V V ++ EGP   P ++   +  N+    K
Sbjct: 344 SLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDK 403

Query: 490 INGYKAYDPE-NRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNIT 548
           +  + A D +  R    +RY   ++P   + +D  +G +     + +E        Y  T
Sbjct: 404 VGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGT 463

Query: 549 VLAIDKD-DRSCTGTLAVNIEDVNDN 573
           +L+ID +  R+CTGT+ +NI+   ++
Sbjct: 464 ILSIDDNLQRTCTGTININIQSFGND 489



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 40/127 (31%), Positives = 60/127 (47%), Gaps = 13/127 (10%)

Query: 767 MGSGMKNGGQETIEMMK--GGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSF 824
           +G G +  G E  E +K  G  +  +   G    +++  CR G   ++           F
Sbjct: 645 LGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMN-----------F 693

Query: 825 TQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEP 884
            +    +K +     ++  PS D +L Y+ EG GSPAGSVGCCS   E+    FL+ L P
Sbjct: 694 MESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGP 753

Query: 885 KFITLAE 891
           KF  LA+
Sbjct: 754 KFKKLAD 760



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 40/166 (24%), Positives = 69/166 (41%), Gaps = 14/166 (8%)

Query: 514 PKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKD-DRSCTGTLAVNIEDVND 572
           P G   I++ +G I  + I+DREV TP   +Y   + ++ +D +R     L V + D+ND
Sbjct: 96  PYGIFVINQKTGEINITSIVDREV-TPFFIIYCRALNSMGQDLERPLE--LRVRVLDIND 152

Query: 573 NPPEILQEYVVICKPKMGYTDIL-----AVDPDEPVH-GAPFYFSLPNTSPEISRLWSLT 626
           NPP            +    + L     A D DEP +  +   F +    P  S ++ + 
Sbjct: 153 NPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIIN 212

Query: 627 K-VNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCEC 671
           +   +     ++     + +Y + +   DR G A         CEC
Sbjct: 213 RNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAE---CEC 255


>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
          Length = 801

 Score =  250 bits (639), Expect = 4e-66
 Identities = 235/792 (29%), Positives = 373/792 (47%), Gaps = 88/792 (11%)

Query: 131 RRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSISGRGVDKEPLNLFYIE 189
           +R KR W      + E   G  PL++ ++ SD  + + ++ Y +SG G       +F I+
Sbjct: 55  QRTKRSWVWNQFFVLEEYTGTDPLYVGKLHSDMDRGDGSIKYILSGEGAGI----VFTID 110

Query: 190 RDTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRVEDENDNHPVFTEAIY 248
             TG++   + +DREE   + L A A     G   +      I+++D NDN P F +  Y
Sbjct: 111 DTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLDGPY 170

Query: 249 NFEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPRSPGLFSVHPSTGVITTV 307
              V E S  GT+V  V ATD D+P   ++ R+ YSILQ  P     FSV   TGVI T 
Sbjct: 171 VATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQP----YFSVDSKTGVIRTA 226

Query: 308 SHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEEN 367
              +DRE  + Y +I++ +DM GQ  GL GT+T  IT++D NDN P F Q  Y+  V E+
Sbjct: 227 LMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMSVLES 286

Query: 368 AFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEE 427
           A  +      +  KDL    N  + +TI+ G+    F ISTD     G+++V KPL++E 
Sbjct: 287 A-PISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKPLSFES 345

Query: 428 NRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVG 487
            +   L++   N     R +      +   V + V D+DE P   P   +V + E++A+G
Sbjct: 346 KKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDVDEPPVFEPGFYFVEVPEDVAIG 405

Query: 488 SKINGYKAYDPENRNGNGLRYK--KLHDPKGWITIDEISGSIITSKILDREVETPKNELY 545
           + I    A DP+  N N +RY   +  DP  +  +D  +G+++T++ LDRE    +   +
Sbjct: 406 TTIQIISAKDPDVTN-NSIRYSIDRSSDPGRFFYVDITTGALMTARPLDRE----EFSWH 460

Query: 546 NITVLAIDKDDRSCTGTLAVNIE--DVNDNPPEILQEY-VVICK-PKMG--YTDILAVDP 599
           NITVLA++ ++ S  G++ V I+  DVNDN PE  + Y   +C+  K G     + AVD 
Sbjct: 461 NITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCENAKAGQLIQTVSAVDQ 520

Query: 600 DEPVHGAPFYFSLPNTSPEISR--LWSLTKVNDTAARLSYQKNAGFQE-----YTIPITV 652
           D+P +G  FY+SL   +PE +    +++    D  AR+   + +GF++     + +PI +
Sbjct: 521 DDPRNGQHFYYSL---APEAANNPNFTIRDNQDNTARI-LTRRSGFRQQEQSVFHLPILI 576

Query: 653 KDRAGQ---AATKLLRVNLCECT---HPTQCRATSRSTGVILGKWAILAILLGIALLFSV 706
            D +GQ   ++T  L + +C C    H   C   +    V L + A++AIL   A +F V
Sbjct: 577 AD-SGQPVLSSTGTLTIQVCSCDDDGHVMSCSPEAYMLPVSLSRGALIAIL---ACIF-V 631

Query: 707 LLTLVCGVFGATKGKRFP-----EDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQ 761
           LL LV  +    + ++ P     E+   +N++  + E  G++       F      N  +
Sbjct: 632 LLVLVLLILSMRRHRKQPYIIDDEENIHENIVRYDDEGGGEE---DTEAFDIAAMWNPRE 688

Query: 762 GFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEW 821
              G      ++   E   + +   QT                              S  
Sbjct: 689 AQAGAAPKTRQDMLPEIESLSRYVPQTCA--------------------------VNSTV 722

Query: 822 HSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGC--CSEKQEEDGLDFL 879
           HS+   +L E        +   P  D + TY +EG GS AGS+     +    E   DFL
Sbjct: 723 HSYVLAKLYEA-----DMDLWAPPFDSLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFL 777

Query: 880 NNLEPKFITLAE 891
            +  P+F  LAE
Sbjct: 778 TDWGPRFRKLAE 789


>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
          Length = 790

 Score =  247 bits (631), Expect = 3e-65
 Identities = 236/803 (29%), Positives = 364/803 (45%), Gaps = 84/803 (10%)

Query: 116 QKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSIS 174
           +K+  +     +  L R+KR W      + E   G    ++ ++ SD  + + ++ Y +S
Sbjct: 34  KKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILS 93

Query: 175 GRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRV 233
           G G      +LF I  +TG++  T+ +DREE  V+ L A A +   G   +      I++
Sbjct: 94  GDGAG----DLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKI 149

Query: 234 EDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPRSP 292
            D NDN P+FT+ +Y   V E S  GT V  V ATD D+P   ++ ++ YSILQ  P   
Sbjct: 150 HDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP--- 206

Query: 293 GLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNA 352
             FSV   TG+I T    +DRE  ++Y ++++ +DM GQ  GL GT+T  IT+TD NDN 
Sbjct: 207 -YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNP 265

Query: 353 PTFRQNAYEAFVEENA-FNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKE 411
           P F Q+ Y+    E++     I RI   D D+    N  + ++I  G     F + TD+E
Sbjct: 266 PRFPQSTYQFKTPESSPPGTPIGRIKASDADV--GENAEIEYSITDGEGLDMFDVITDQE 323

Query: 412 TNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPEC 471
           T EG+++V K L++E+ +   L++  +N     R +      + A V + V D+DE P  
Sbjct: 324 TQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVF 383

Query: 472 TPAAQYVRIKENLAVGSKINGYKAYDPE-NRNGNGLRYKKLHDPKGWITIDEISGSIITS 530
           +  A  ++I+E+  + + I    A DP+  RN       +  D      ID  +GSI TS
Sbjct: 384 SKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTS 443

Query: 531 KILDREVETPKNELYNITVLA--IDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPK 588
           K+LDRE        +NITV+A  I+   +S    L + + DVNDN PE  + Y      K
Sbjct: 444 KLLDRETLL----WHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEK 499

Query: 589 MGYTDIL----AVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQ 644
                ++    AVD D+P  G  F FSL   +   S        ++TA  L+ +      
Sbjct: 500 AKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRH 559

Query: 645 E---YTIPITVKDR--AGQAATKLLRVNLCECTH---PTQCRATSRSTGVILGKWAILAI 696
           E   Y +P+ + D     Q++T  + V +C C H      C A +      L   A++AI
Sbjct: 560 EMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAI 619

Query: 697 LLGIALLFSVLLTLVCGVFGATKGKRFPEDL------AQQNLIISNTEAPGDDRVCSANG 750
           LL I +L   L+T+V  +F A + +R  E L       + N++  N E  G++       
Sbjct: 620 LLCIVIL---LVTVV--LFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEE---DTQA 671

Query: 751 FMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTE 810
           F   T  N                  E IE  K     +           L   R   T 
Sbjct: 672 FDIGTLRN-----------------PEAIEDNKLRRDIVP--------EALFLPRRTPTA 706

Query: 811 VDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSE- 869
            DN     ++   F   RL E     N  +   P  D + TY YEG GS A S+      
Sbjct: 707 RDN-----TDVRDFINQRLKE-----NDTDPTAPPYDSLATYAYEGTGSVADSLSSLESV 756

Query: 870 -KQEEDGLDFLNNLEPKFITLAE 891
               +   D+L++  P+F  LA+
Sbjct: 757 TTDADQDYDYLSDWGPRFKKLAD 779


>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
          Length = 788

 Score =  247 bits (630), Expect = 4e-65
 Identities = 238/808 (29%), Positives = 367/808 (45%), Gaps = 95/808 (11%)

Query: 116 QKKVSKTRHTRET--VLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYS 172
           Q+++  +R  R    +L R KR W      + E   G    ++ ++ SD  + + ++ Y 
Sbjct: 33  QQRILSSRVPRSDGKILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYI 92

Query: 173 ISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLP-LPLPI 231
           +SG G       LF I+  TG++  TR +DREE   + L A A          P     I
Sbjct: 93  LSGDGAG----TLFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVI 148

Query: 232 RVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPR 290
           ++ D NDN P F E IY   V E S  GT+V  V ATD D+P   ++ R+ YSILQ  P 
Sbjct: 149 KIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQP- 207

Query: 291 SPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSND 350
               FSV P TG+I T    ++RE  ++Y ++++ +DM GQ  GL GT+T  IT+TD ND
Sbjct: 208 ---YFSVEPETGIIRTALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVND 264

Query: 351 NAPTFRQNAYEAFV-EENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTD 409
           N P F QN     V E +     I  +   D D     N  V + I+ G+    F I T+
Sbjct: 265 NPPRFPQNTIHLRVLESSPVGTAIGSVKATDAD--TGKNAEVEYRIIDGDGTDMFDIVTE 322

Query: 410 KETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGP 469
           K+T EG+++V KPL+YE  R   L++   N     R        +  +V + + D+DE P
Sbjct: 323 KDTQEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDVDEPP 382

Query: 470 ECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYK--KLHDPKGWITIDEISGSI 527
             + ++    + E++ VG+ I    A DP++ + + +R+   +  D      I   +GS+
Sbjct: 383 VFSRSSYLFEVHEDIEVGTIIGTVMARDPDSIS-SPIRFSLDRHTDLDRIFNIHSGNGSL 441

Query: 528 ITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLA--VNIEDVNDNPPEILQEY-VVI 584
            TSK LDRE+    ++ +N+TV+A + ++   T  +A  V I DVNDN P+    Y   +
Sbjct: 442 YTSKPLDREL----SQWHNLTVIAAEINNPKETTRVAVFVRILDVNDNAPQFAVFYDTFV 497

Query: 585 C---KPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNA 641
           C   +P      I AVD D+P+ G  F+FSL   +P     +++    D  AR+  +KN 
Sbjct: 498 CENARPGQLIQTISAVDKDDPLGGQKFFFSLAAVNPN----FTVQDNEDNTARILTRKN- 552

Query: 642 GFQE-----YTIPITVKDR--AGQAATKLLRVNLCECT---HPTQCRATSRSTGVILGKW 691
           GF       Y +P+ + D     Q++T  L + +C C    +   C A +      L   
Sbjct: 553 GFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTG 612

Query: 692 AILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDL------AQQNLIISNTEAPGDDRV 745
           A++AILL I     ++L ++  +F A K +R  E L       + N++  N E  G++  
Sbjct: 613 ALIAILLCI-----IILLVIVVLFAALKRQRKKEPLILSKEDIRDNIVSYNDEGGGEE-- 665

Query: 746 CSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCR 805
                F   T  N +                  IE  K     +          TL   R
Sbjct: 666 -DTQAFDIGTLRNPA-----------------AIEEKKLRRDIIP--------ETLFIPR 699

Query: 806 GGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVG 865
              T  DN     ++   F   RL E     +  +   P  D + TY YEG  S A S+ 
Sbjct: 700 RTPTAPDN-----TDVRDFINERLKE-----HDLDPTAPPYDSLATYAYEGNDSIAESLS 749

Query: 866 CCSE--KQEEDGLDFLNNLEPKFITLAE 891
                  + +   D+L    P+F  LAE
Sbjct: 750 SLESGTTEGDQNYDYLREWGPRFNKLAE 777


>gi|221316595 cadherin 17 precursor [Homo sapiens]
          Length = 832

 Score =  246 bits (629), Expect = 5e-65
 Identities = 182/601 (30%), Positives = 286/601 (47%), Gaps = 42/601 (6%)

Query: 138 APIPCSMQENSLGPFPLFLQQVE-SDAAQNYTVFYSISGRGVDKEPLNLFYIERDT-GNL 195
           AP P  M ENS  P P+ + QV  +D    Y++        VDKE L  F    D  G++
Sbjct: 241 APKPVEMVENSTDPHPIKITQVRWNDPGAQYSL--------VDKEKLPRFPFSIDQEGDI 292

Query: 196 FCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLES 255
           + T+P+DREE D +   A A    G     PL + ++V+D NDN P     +  FEV E+
Sbjct: 293 YVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQEN 352

Query: 256 SRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSP--GLFSVHPSTGVITTVSHYLDR 313
            R G ++G + A DRDE +T ++ L Y I++QTP+ P  GLF +    G++      L +
Sbjct: 353 ERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKK 412

Query: 314 EVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYE--AFVEENAFNV 371
           +   +Y+L ++V D D +    +      I V D ND  P F ++ Y      E+     
Sbjct: 413 QDTPQYNLTIEVSDKDFKTLCFVQ-----INVIDINDQIPIFEKSDYGNLTLAEDTNIGS 467

Query: 372 EILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQV 431
            IL I   D D   T + ++ + I+KG+  G   + TD  TN G + + KPL++E     
Sbjct: 468 TILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVS 527

Query: 432 NLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKIN 491
           N+     N  P    + +  A + A  T+ V D++E P+ +      ++ E++A+G+K+ 
Sbjct: 528 NIVFKAENPEPLVFGV-KYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVG 586

Query: 492 GYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLA 551
              A DPE   G  + Y    D +GW+ ID ++G I +   LDRE  +P    Y + V+A
Sbjct: 587 NVTAKDPE---GLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSP----YRVQVVA 639

Query: 552 IDKDDRSCTGTLAVN--IEDVNDNPPEILQEY--VVICKPKMGYTDILAVDPDEPVH--- 604
            +    S +     +  + DVNDNPP + ++Y  +  C P      ++    D+  H   
Sbjct: 640 TEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFR 699

Query: 605 GAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQ--EYTIPITVKD--RAGQAA 660
           G  F FSL + S  +   W ++K+N T ARLS  ++  F+  EY + I + D  R     
Sbjct: 700 GPHFTFSLGSGS--LQNDWEVSKINGTHARLS-TRHTEFEEREYVVLIRINDGGRPPLEG 756

Query: 661 TKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKG 720
              L V  C C   +  R     TG+     A+  ILL   L+  ++L +V       KG
Sbjct: 757 IVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAV-GILLTTLLVIGIILAVVFIRIKKDKG 815

Query: 721 K 721
           K
Sbjct: 816 K 816



 Score =  117 bits (294), Expect = 4e-26
 Identities = 122/446 (27%), Positives = 202/446 (45%), Gaps = 52/446 (11%)

Query: 184 NLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVF 243
           N+F IER+ G L+  R +DRE     +L   A  A+G   + P+P+ I+V+D NDN P F
Sbjct: 68  NIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTF 126

Query: 244 TEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGL--FSVHPST 301
            ++ Y   V ++SRPG     V ATD D+P T + +L Y I+ Q P    +  F ++  T
Sbjct: 127 LQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKT 186

Query: 302 GVITTV---SHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCI-ITVTDSNDNAPTFRQ 357
           G I+     S  L+      Y+L++ V+DM GQ       +T + I VT++   AP    
Sbjct: 187 GAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPK--- 243

Query: 358 NAYEAFVEENAFNVEILRIPIEDKDLINTANWR---VNFTILKGNENGHFKISTDKETNE 414
                 + EN+ +   ++        I    W      ++++   +   F  S D+   E
Sbjct: 244 ---PVEMVENSTDPHPIK--------ITQVRWNDPGAQYSLVDKEKLPRFPFSIDQ---E 289

Query: 415 GVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPA 474
           G + V +PL+ EE           +E       P         + V V+D+++ P   P+
Sbjct: 290 GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYP-------LEIHVKVKDINDNPPTCPS 342

Query: 475 AQYV-RIKENLAVGSKINGYKAY--DPENRNGNGLRYKKLHD-PK----GWITIDEISGS 526
              V  ++EN  +G+ I    A+  D EN   + L Y+ +   PK    G   I   +G 
Sbjct: 343 PVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGM 402

Query: 527 IITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQ----EYV 582
           +  +K   ++ +TP+   YN+T+   DKD ++    + +N+ D+ND  P   +       
Sbjct: 403 LQLAKQSLKKQDTPQ---YNLTIEVSDKDFKTLC-FVQINVIDINDQIPIFEKSDYGNLT 458

Query: 583 VICKPKMGYT--DILAVDPDEPVHGA 606
           +     +G T   I A D DEP  G+
Sbjct: 459 LAEDTNIGSTILTIQATDADEPFTGS 484


>gi|221316593 cadherin 17 precursor [Homo sapiens]
          Length = 832

 Score =  246 bits (629), Expect = 5e-65
 Identities = 182/601 (30%), Positives = 286/601 (47%), Gaps = 42/601 (6%)

Query: 138 APIPCSMQENSLGPFPLFLQQVE-SDAAQNYTVFYSISGRGVDKEPLNLFYIERDT-GNL 195
           AP P  M ENS  P P+ + QV  +D    Y++        VDKE L  F    D  G++
Sbjct: 241 APKPVEMVENSTDPHPIKITQVRWNDPGAQYSL--------VDKEKLPRFPFSIDQEGDI 292

Query: 196 FCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLES 255
           + T+P+DREE D +   A A    G     PL + ++V+D NDN P     +  FEV E+
Sbjct: 293 YVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQEN 352

Query: 256 SRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSP--GLFSVHPSTGVITTVSHYLDR 313
            R G ++G + A DRDE +T ++ L Y I++QTP+ P  GLF +    G++      L +
Sbjct: 353 ERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKK 412

Query: 314 EVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYE--AFVEENAFNV 371
           +   +Y+L ++V D D +    +      I V D ND  P F ++ Y      E+     
Sbjct: 413 QDTPQYNLTIEVSDKDFKTLCFVQ-----INVIDINDQIPIFEKSDYGNLTLAEDTNIGS 467

Query: 372 EILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQV 431
            IL I   D D   T + ++ + I+KG+  G   + TD  TN G + + KPL++E     
Sbjct: 468 TILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVS 527

Query: 432 NLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKIN 491
           N+     N  P    + +  A + A  T+ V D++E P+ +      ++ E++A+G+K+ 
Sbjct: 528 NIVFKAENPEPLVFGV-KYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVG 586

Query: 492 GYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLA 551
              A DPE   G  + Y    D +GW+ ID ++G I +   LDRE  +P    Y + V+A
Sbjct: 587 NVTAKDPE---GLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSP----YRVQVVA 639

Query: 552 IDKDDRSCTGTLAVN--IEDVNDNPPEILQEY--VVICKPKMGYTDILAVDPDEPVH--- 604
            +    S +     +  + DVNDNPP + ++Y  +  C P      ++    D+  H   
Sbjct: 640 TEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFR 699

Query: 605 GAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQ--EYTIPITVKD--RAGQAA 660
           G  F FSL + S  +   W ++K+N T ARLS  ++  F+  EY + I + D  R     
Sbjct: 700 GPHFTFSLGSGS--LQNDWEVSKINGTHARLS-TRHTEFEEREYVVLIRINDGGRPPLEG 756

Query: 661 TKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKG 720
              L V  C C   +  R     TG+     A+  ILL   L+  ++L +V       KG
Sbjct: 757 IVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAV-GILLTTLLVIGIILAVVFIRIKKDKG 815

Query: 721 K 721
           K
Sbjct: 816 K 816



 Score =  117 bits (294), Expect = 4e-26
 Identities = 122/446 (27%), Positives = 202/446 (45%), Gaps = 52/446 (11%)

Query: 184 NLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVF 243
           N+F IER+ G L+  R +DRE     +L   A  A+G   + P+P+ I+V+D NDN P F
Sbjct: 68  NIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTF 126

Query: 244 TEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGL--FSVHPST 301
            ++ Y   V ++SRPG     V ATD D+P T + +L Y I+ Q P    +  F ++  T
Sbjct: 127 LQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKT 186

Query: 302 GVITTV---SHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCI-ITVTDSNDNAPTFRQ 357
           G I+     S  L+      Y+L++ V+DM GQ       +T + I VT++   AP    
Sbjct: 187 GAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPK--- 243

Query: 358 NAYEAFVEENAFNVEILRIPIEDKDLINTANWR---VNFTILKGNENGHFKISTDKETNE 414
                 + EN+ +   ++        I    W      ++++   +   F  S D+   E
Sbjct: 244 ---PVEMVENSTDPHPIK--------ITQVRWNDPGAQYSLVDKEKLPRFPFSIDQ---E 289

Query: 415 GVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPA 474
           G + V +PL+ EE           +E       P         + V V+D+++ P   P+
Sbjct: 290 GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYP-------LEIHVKVKDINDNPPTCPS 342

Query: 475 AQYV-RIKENLAVGSKINGYKAY--DPENRNGNGLRYKKLHD-PK----GWITIDEISGS 526
              V  ++EN  +G+ I    A+  D EN   + L Y+ +   PK    G   I   +G 
Sbjct: 343 PVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGM 402

Query: 527 IITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQ----EYV 582
           +  +K   ++ +TP+   YN+T+   DKD ++    + +N+ D+ND  P   +       
Sbjct: 403 LQLAKQSLKKQDTPQ---YNLTIEVSDKDFKTLC-FVQINVIDINDQIPIFEKSDYGNLT 458

Query: 583 VICKPKMGYT--DILAVDPDEPVHGA 606
           +     +G T   I A D DEP  G+
Sbjct: 459 LAEDTNIGSTILTIQATDADEPFTGS 484


>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
          Length = 796

 Score =  245 bits (625), Expect = 2e-64
 Identities = 236/801 (29%), Positives = 361/801 (45%), Gaps = 101/801 (12%)

Query: 129 VLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDA-AQNYTVFYSISGRGVDKEPLNLFY 187
           VL+R+KR W      + E   GP P+ + ++ SD  + +  + Y +SG G       +F 
Sbjct: 47  VLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAG----TIFV 102

Query: 188 IERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLP----IRVEDENDNHPVF 243
           I+  +GN+  T+ +DREE   + L+A A   D    + PL  P    ++V+D NDN P F
Sbjct: 103 IDDKSGNIHATKTLDREERAQYTLMAQAVDRD---TNRPLEPPSEFIVKVQDINDNPPEF 159

Query: 244 TEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPRSPGLFSVHPSTG 302
               Y+  V E S  GT+V  V A+D D+P   ++ +L YSIL+  P     FSV   TG
Sbjct: 160 LHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQP----YFSVEAQTG 215

Query: 303 VITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEA 362
           +I T    +DRE  ++Y ++++ +DM G   GL GT+   IT+TD NDN P F Q+ Y+ 
Sbjct: 216 IIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQM 275

Query: 363 FVEENAF-NVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVK 421
            V E A    E+ R+  +D D+    N  V + I+ G+    F+I+TD ET EGV+ + K
Sbjct: 276 SVSEAAVPGEEVGRVKAKDPDI--GENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKK 333

Query: 422 PLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIK 481
           P+++E  R  +L++   N     + I      +   V + V D DE P     +    ++
Sbjct: 334 PVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQ 393

Query: 482 ENLAVGSKINGYKAYDPENRNGNGLRYK--KLHDPKGWITIDEISGSIITSKILDREVET 539
           EN A G+ +    A DP+  N + +RY   +  D   + TI+   G I T+K LDRE   
Sbjct: 394 ENAAAGTVVGRVHAKDPDAAN-SPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDRE--- 449

Query: 540 PKNELYNITVLAIDKDDR--SCTGTLAVNIEDVNDNPPEILQEYV-VIC-----KP--KM 589
            +    NITV A +  +R       +A+ + DVNDN P+    Y   IC     KP    
Sbjct: 450 -ETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQ 508

Query: 590 GYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLS--YQKNAGFQE-- 645
               I A D D+  +G  F FSLP   PEI    + T V D     +  Y +  GF    
Sbjct: 509 PIVTISADDKDDTANGPRFIFSLP---PEIIHNPNFT-VRDNRDNTAGVYARRGGFSRQK 564

Query: 646 ---YTIPITVKDRA--GQAATKLLRVNLCECT---HPTQCRATSRSTGVILGKWAILAIL 697
              Y +PI + D      ++T  L + +C C        C A +      L   A++AIL
Sbjct: 565 QDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAIL 624

Query: 698 LGIALLFSVLLTLVCGVFGATKGKR-----FPEDLAQQNLIISNTEAPGDDRVCSANGFM 752
             I +L  +++  V       + K+     F E+  ++N+I  + E  G++    A    
Sbjct: 625 ACIVILLVIVVLFVT----LRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDT-EAFDIA 679

Query: 753 TQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVD 812
           T    +   GF        K+   E   M + G +   +                  +VD
Sbjct: 680 TLQNPDGINGFI-----PRKDIKPEYQYMPRPGLRPAPN----------------SVDVD 718

Query: 813 NCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQE 872
           +          F   R+ E       N+   P  D +  Y YEGRGS AGS+        
Sbjct: 719 D----------FINTRIQEA-----DNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATT 763

Query: 873 EDGL--DFLNNLEPKFITLAE 891
           +  L  D+L N  P+F  LA+
Sbjct: 764 DSDLDYDYLQNWGPRFKKLAD 784


>gi|16753221 cadherin 22 precursor [Homo sapiens]
          Length = 828

 Score =  234 bits (597), Expect = 3e-61
 Identities = 221/783 (28%), Positives = 346/783 (44%), Gaps = 52/783 (6%)

Query: 132 RAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSISGRGVDKEPLNLFYIER 190
           R KR W      + E   G  PL++ ++ SD+ + +  + Y+ISG G       +F I+ 
Sbjct: 59  RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAG----TIFLIDE 114

Query: 191 DTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRVEDENDNHPVFTEAIYN 249
            TG++     +DRE+   + L A A   A     +      I+V+D ND+ P F    Y 
Sbjct: 115 LTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYI 174

Query: 250 FEVLESSRPGTTVGVVCATDRDEPDT-MHTRLKYSILQQTPRSPGLFSVHPSTGVITTVS 308
             V E S  GT+V  V A+D D+P      RL YS+L         F+V P TGVI T  
Sbjct: 175 GSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHH----FTVDPKTGVIRTAV 230

Query: 309 HYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENA 368
             LDRE  ++Y ++++  DM GQ  GL G++T  I VTD NDN P F Q  Y+  ++E+A
Sbjct: 231 PDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESA 290

Query: 369 -FNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEE 427
                + R+  ED D+    +   +      +    FK++TD +T E ++ V K L++E 
Sbjct: 291 PIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFES 350

Query: 428 NRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVG 487
                + +   N+    R     T  ++A+V V V D+DE PE  P +  + ++E+  VG
Sbjct: 351 QPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVG 410

Query: 488 SKINGYKAYDPENRNGNGLRY--KKLHDPKGWITIDEISGSIITSKILDREVETPKNELY 545
           S +    A DP+  N   +RY   +  D      ID  +G+I+T K LDRE        +
Sbjct: 411 SLVGVVTARDPDAAN-RPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETA----GWH 465

Query: 546 NITVLAIDKDDRS--CTGTLAVNIEDVNDNPPEILQEY-VVIC---KPKMGYTDILAVDP 599
           NITVLA++ D+ +     +L + I DVNDNPPE+   Y   +C   KP      I  VD 
Sbjct: 466 NITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDR 525

Query: 600 DEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQE-----YTIPITVKD 654
           DEP  G  FYF L   +P  +  +SL  + D  A + + ++ GF       + +PI V D
Sbjct: 526 DEPQGGHRFYFRLVPEAPS-NPHFSLLDIQDNTAAV-HTQHVGFNRQEQDVFFLPILVVD 583

Query: 655 RAGQ--AATKLLRVNLCECTHP---TQCRATSRSTGVILGKWAILAILLGIALLFSVLLT 709
                 ++T  L + +C C        C  T+      L   A++A+L+ + +L  ++L 
Sbjct: 584 SGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLL 643

Query: 710 LVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGS 769
           ++             ED   ++ +I   +  G ++   A       +        G  G 
Sbjct: 644 ILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGG 703

Query: 770 GMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRL 829
           G   GG        GG  +          H+L        E D     +S +  F   ++
Sbjct: 704 GSAGGGAG--GGSGGGAGSPPQAHLPSERHSLPQ-GPPSPEPD-----FSVFRDFISRKV 755

Query: 830 GEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGC--CSEKQEEDGLDFLNNLEPKFI 887
                     +  +P  D   TY +EG  SPA S+          E    +L++  P+F 
Sbjct: 756 A-----LADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFR 810

Query: 888 TLA 890
            LA
Sbjct: 811 PLA 813


>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
          Length = 789

 Score =  229 bits (585), Expect = 7e-60
 Identities = 193/668 (28%), Positives = 322/668 (48%), Gaps = 55/668 (8%)

Query: 110 TVLLEHQ-------KKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESD 162
           T+LL+ +       KK++        +LRR KR W      + E   G    ++ ++ +D
Sbjct: 21  TILLQEKPNSYLSSKKIAGLTKDDGKMLRRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTD 80

Query: 163 AAQ-NYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYA-STADG 220
             + +  + Y ++G G      +LF I+ +TG++   + +DREE  ++ L A A     G
Sbjct: 81  QDKGDGNLKYILTGDGAG----SLFVIDENTGDIHAAKKLDREEKSLYILRAKAIDRKTG 136

Query: 221 YSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHT-R 279
              +      I++ D NDN P FT+ +Y   V E S  GT+V  V ATD D+ +  ++ +
Sbjct: 137 RQVEPESEFIIKIHDINDNEPKFTKDLYTASVPEMSGVGTSVIQVTATDADDANYGNSAK 196

Query: 280 LKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTS 339
           + YSILQ  P     FSV P +G+I T    + RE  ++Y ++++ +DM GQ  GL GT+
Sbjct: 197 VVYSILQGQP----YFSVDPESGIIKTALPDMSRENREQYQVVIQAKDMGGQMGGLSGTT 252

Query: 340 TCIITVTDSNDNAPTFRQNAYEAFVEENA-FNVEILRIPIEDKDLINTANWRVNFTILKG 398
           T  IT+TD N+N P F Q+ Y+    E+      + RI   D D+   A   + ++I +G
Sbjct: 253 TVNITLTDVNNNPPRFPQSTYQFNSPESVPLGTHLGRIKANDPDVGENAE--MEYSIAEG 310

Query: 399 NENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALV 458
           +    F + TDK+T EG+++V + L++E      L +  +N  P  R +      + A+V
Sbjct: 311 DGADMFDVITDKDTQEGIITVKQNLDFENQMLYTLRVDASNTHPDPRFLHLGPFKDTAVV 370

Query: 459 TVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYK--KLHDPKG 516
            + V D+DE P  T  +  + + E++  GS I    AYDP+ RN N ++Y   +  D   
Sbjct: 371 KISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQVTAYDPDARN-NLIKYSVDRHTDMDR 429

Query: 517 WITIDEISGSIITSKILDREVETPKNELYNITVLA--IDKDDRSCTGTLAVNIEDVNDNP 574
              I   +GSI T K LDRE     +  +NITV A  I+   +S    + + I D+ND+ 
Sbjct: 430 IFGIHSENGSIFTLKALDRE----SSPWHNITVTATEINNPKQSSHIPVFIRILDINDHA 485

Query: 575 PEILQEY-VVIC---KPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVND 630
           PE    Y   +C   KP      +  +D D+P  G  F+F  P     ++  +++    D
Sbjct: 486 PEFAMYYETFVCENAKPGQLIQTVSVMDKDDPPRGHKFFFE-PVPEFTLNPNFTIVDNKD 544

Query: 631 TAARLSYQKNA----GFQEYTIPITV--KDRAGQAATKLLRVNLCECTHP---TQCRATS 681
             A +  +K+         Y +PI +   D   Q++T  L + +C C +      C A +
Sbjct: 545 NTAGIMTRKDGYSRNKMSTYLLPILIFDNDYPIQSSTGTLTIRVCACDNQGNMQSCTAEA 604

Query: 682 RSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDL------AQQNLIIS 735
                 L   A++AILL + +L  +++     +F A K +R  E L       + N++  
Sbjct: 605 LILSAGLSTGALVAILLCVLILLILVV-----LFAALKRQRKKEPLIISKDDVRDNIVTY 659

Query: 736 NTEAPGDD 743
           N E  G++
Sbjct: 660 NDEGGGEE 667


>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
          Length = 799

 Score =  226 bits (577), Expect = 6e-59
 Identities = 219/798 (27%), Positives = 356/798 (44%), Gaps = 95/798 (11%)

Query: 127 ETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSISGRGVDKEPLNL 185
           + +L R+KR W      + E   GP P+ + ++ +D    +  + Y +SG G       +
Sbjct: 53  QRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAG----TI 108

Query: 186 FYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLP----IRVEDENDNHP 241
           F I   TG++   + +DREE   + L A A     +    PL  P    I+V+D NDN P
Sbjct: 109 FQINDVTGDIHAIKRLDREEKAEYTLTAQAVD---WETSKPLEPPSEFIIKVQDINDNAP 165

Query: 242 VFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPRSPGLFSVHPS 300
            F    Y+  V E S  GT+V  V ATD D+P   ++ +L YSIL+  P     FS+ P 
Sbjct: 166 EFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQP----YFSIEPE 221

Query: 301 TGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAY 360
           T +I T    +DRE  ++Y ++++ +DM G   GL GT+T  +T+TD NDN P F Q+ Y
Sbjct: 222 TAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLY 281

Query: 361 EAFVEEN-AFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSV 419
              V E+      I R+   D+D+    N + ++ I+ G+    F+I++D +  +G++ +
Sbjct: 282 HFSVPEDVVLGTAIGRVKANDQDI--GENAQSSYDIIDGDGTALFEITSDAQAQDGIIRL 339

Query: 420 VKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVR 479
            KPL++E  +   L++   N     R   R    + A V + V D DE P  +     + 
Sbjct: 340 RKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLE 399

Query: 480 IKENLAVGSKINGYKAYDPENRNGNGLRYK--KLHDPKGWITIDEISGSIITSKILDREV 537
           + EN A+ S I    A DP+    + +R+   +  D +    I+   G I  +  LDRE+
Sbjct: 400 VHENAALNSVIGQVTARDPD-ITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDREL 458

Query: 538 ETPKNELYNITVLAIDKDDRSCTG--TLAVNIEDVNDNPPEILQEY-VVIC---KPKMGY 591
                  +NIT++A +  + S      +A+ + DVNDN PE   EY   +C   KP    
Sbjct: 459 SV----WHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVI 514

Query: 592 TDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLT-KVNDTAARLSYQKNAGF-----QE 645
             + A+D D+P +G  F +SL    PE+    + T K N+  +     K+ GF     + 
Sbjct: 515 QTVSAMDKDDPKNGHYFLYSL---LPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEV 571

Query: 646 YTIPITVKDRAGQ--AATKLLRVNLCECTHP---TQCRATSRSTGVILGKWAILAILLGI 700
           Y +PI + D      ++T  L + +C C++      C   +    + L   A++AIL  I
Sbjct: 572 YLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACI 631

Query: 701 ALLFSVLLTLVCGVFGATKGKRFP-----EDLAQQNLIISNTEAPGDDRVCSANGFMTQT 755
            LL  +++  V       + K  P     ++  ++N+I  + E  G++       F   T
Sbjct: 632 ILLLVIVVLFVT----LRRHKNEPLIIKDDEDVRENIIRYDDEGGGEE---DTEAFDIAT 684

Query: 756 TNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCR 815
             N      G  G   +   +  ++ M                      R G   V N  
Sbjct: 685 LQNPD----GINGFLPRKDIKPDLQFMP---------------------RQGLAPVPN-- 717

Query: 816 YTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGC--CSEKQEE 873
               +   F   RL E       N+   P  D +  Y YEGRGS AGS+     +    +
Sbjct: 718 --GVDVDEFINVRLHEA-----DNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSD 770

Query: 874 DGLDFLNNLEPKFITLAE 891
              D+L++  P+F  L E
Sbjct: 771 QNFDYLSDWGPRFKRLGE 788


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,337,316
Number of Sequences: 37866
Number of extensions: 1666204
Number of successful extensions: 7119
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 196
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 3562
Number of HSP's gapped (non-prelim): 949
length of query: 896
length of database: 18,247,518
effective HSP length: 111
effective length of query: 785
effective length of database: 14,044,392
effective search space: 11024847720
effective search space used: 11024847720
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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