Search of human proteins with 148223541

Search of human proteins with 148223541

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148223541 calcium channel, voltage-dependent, beta 2 subunit
isoform 6 [Homo sapiens]
         (632 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148223541 calcium channel, voltage-dependent, beta 2 subunit ...  1262   0.0  
gi|147898681 calcium channel, voltage-dependent, beta 2 subunit ...  1239   0.0  
gi|148232726 calcium channel, voltage-dependent, beta 2 subunit ...  1179   0.0  
gi|45359834 calcium channel, voltage-dependent, beta 2 subunit i...  1179   0.0  
gi|148226485 calcium channel, voltage-dependent, beta 2 subunit ...  1179   0.0  
gi|147904948 calcium channel, voltage-dependent, beta 2 subunit ...  1155   0.0  
gi|147901383 calcium channel, voltage-dependent, beta 2 subunit ...  1134   0.0  
gi|45359842 calcium channel, voltage-dependent, beta 2 subunit i...  1133   0.0  
gi|40804468 calcium channel, voltage-dependent, beta 1 subunit i...   726   0.0  
gi|40804470 calcium channel, voltage-dependent, beta 1 subunit i...   711   0.0  
gi|40804472 calcium channel, voltage-dependent, beta 1 subunit i...   669   0.0  
gi|54607066 calcium channel, voltage-dependent, beta 4 subunit i...   631   0.0  
gi|54607064 calcium channel, voltage-dependent, beta 4 subunit i...   631   0.0  
gi|54607068 calcium channel, voltage-dependent, beta 4 subunit i...   613   e-175
gi|224831262 calcium channel, voltage-dependent, beta 4 subunit ...   534   e-152
gi|40316928 calcium channel, voltage-dependent, beta 3 subunit [...   533   e-151
gi|50962882 G patch domain containing 8 [Homo sapiens]                 58   3e-08
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi...    54   6e-07
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]           52   2e-06
gi|4504487 histidine rich calcium binding protein precursor [Hom...    50   5e-06
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        49   2e-05
gi|9945320 cyclin L1 [Homo sapiens]                                    48   3e-05
gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s...    47   4e-05
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ...    46   1e-04
gi|14149807 coiled-coil domain containing 55 isoform 1 [Homo sap...    45   2e-04
gi|23111062 splicing factor, arginine/serine-rich 8 [Homo sapiens]     45   2e-04
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]          44   5e-04
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    43   8e-04
gi|155030236 ribonuclease III, nuclear isoform 2 [Homo sapiens]        43   8e-04
gi|155030234 ribonuclease III, nuclear isoform 1 [Homo sapiens]        43   8e-04

>gi|148223541 calcium channel, voltage-dependent, beta 2 subunit
           isoform 6 [Homo sapiens]
          Length = 632

 Score = 1262 bits (3266), Expect = 0.0
 Identities = 632/632 (100%), Positives = 632/632 (100%)

Query: 1   MNQGSGLDLLKISYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSL 60
           MNQGSGLDLLKISYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSL
Sbjct: 1   MNQGSGLDLLKISYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSL 60

Query: 61  EEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFL 120
           EEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFL
Sbjct: 61  EEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFL 120

Query: 121 HVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSL 180
           HVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSL
Sbjct: 121 HVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSL 180

Query: 181 GDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKK 240
           GDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKK
Sbjct: 181 GDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKK 240

Query: 241 TEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLA 300
           TEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLA
Sbjct: 241 TEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLA 300

Query: 301 KRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTS 360
           KRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTS
Sbjct: 301 KRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTS 360

Query: 361 LAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLED 420
           LAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLED
Sbjct: 361 LAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLED 420

Query: 421 ACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSA 480
           ACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSA
Sbjct: 421 ACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSA 480

Query: 481 PIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYV 540
           PIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYV
Sbjct: 481 PIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYV 540

Query: 541 EPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRH 600
           EPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRH
Sbjct: 541 EPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRH 600

Query: 601 KSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ 632
           KSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ
Sbjct: 601 KSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ 632


>gi|147898681 calcium channel, voltage-dependent, beta 2 subunit
           isoform 2 [Homo sapiens]
          Length = 660

 Score = 1239 bits (3207), Expect = 0.0
 Identities = 620/620 (100%), Positives = 620/620 (100%)

Query: 13  SYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAE 72
           SYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAE
Sbjct: 41  SYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAE 100

Query: 73  RQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWI 132
           RQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWI
Sbjct: 101 RQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWI 160

Query: 133 GRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTP 192
           GRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTP
Sbjct: 161 GRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTP 220

Query: 193 PSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPS 252
           PSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPS
Sbjct: 221 PSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPS 280

Query: 253 MRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHA 312
           MRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHA
Sbjct: 281 MRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHA 340

Query: 313 IIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISS 372
           IIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISS
Sbjct: 341 IIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISS 400

Query: 373 PKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAY 432
           PKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAY
Sbjct: 401 PKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAY 460

Query: 433 WKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEP 492
           WKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEP
Sbjct: 461 WKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEP 520

Query: 493 SVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVD 552
           SVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVD
Sbjct: 521 SVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVD 580

Query: 553 HYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGE 612
           HYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGE
Sbjct: 581 HYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGE 640

Query: 613 VISKKRNEAGEWNRDVYIRQ 632
           VISKKRNEAGEWNRDVYIRQ
Sbjct: 641 VISKKRNEAGEWNRDVYIRQ 660


>gi|148232726 calcium channel, voltage-dependent, beta 2 subunit
           isoform 1 [Homo sapiens]
          Length = 605

 Score = 1179 bits (3051), Expect = 0.0
 Identities = 590/592 (99%), Positives = 590/592 (99%)

Query: 41  VRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAA 100
           V  GSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAA
Sbjct: 14  VSYGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAA 73

Query: 101 HEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQ 160
           HEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQ
Sbjct: 74  HEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQ 133

Query: 161 RAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKP 220
           RAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKP
Sbjct: 134 RAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKP 193

Query: 221 SANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFL 280
           SANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFL
Sbjct: 194 SANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFL 253

Query: 281 KHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTL 340
           KHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTL
Sbjct: 254 KHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTL 313

Query: 341 QLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADK 400
           QLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADK
Sbjct: 314 QLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADK 373

Query: 401 LAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLS 460
           LAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLS
Sbjct: 374 LAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLS 433

Query: 461 PTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRG 520
           PTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRG
Sbjct: 434 PTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRG 493

Query: 521 LSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHR 580
           LSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHR
Sbjct: 494 LSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHR 553

Query: 581 SRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ 632
           SRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ
Sbjct: 554 SRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ 605


>gi|45359834 calcium channel, voltage-dependent, beta 2 subunit
           isoform 7 [Homo sapiens]
          Length = 612

 Score = 1179 bits (3049), Expect = 0.0
 Identities = 589/589 (100%), Positives = 589/589 (100%)

Query: 44  GSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHED 103
           GSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHED
Sbjct: 24  GSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHED 83

Query: 104 DVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAK 163
           DVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAK
Sbjct: 84  DVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAK 143

Query: 164 QGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSAN 223
           QGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSAN
Sbjct: 144 QGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSAN 203

Query: 224 SVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHR 283
           SVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHR
Sbjct: 204 SVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHR 263

Query: 284 FEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLV 343
           FEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLV
Sbjct: 264 FEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLV 323

Query: 344 VLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQ 403
           VLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQ
Sbjct: 324 VLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQ 383

Query: 404 CPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTL 463
           CPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTL
Sbjct: 384 CPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTL 443

Query: 464 ASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSR 523
           ASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSR
Sbjct: 444 ASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSR 503

Query: 524 QETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRD 583
           QETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRD
Sbjct: 504 QETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRD 563

Query: 584 VDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ 632
           VDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ
Sbjct: 564 VDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ 612


>gi|148226485 calcium channel, voltage-dependent, beta 2 subunit
           isoform 3 [Homo sapiens]
          Length = 606

 Score = 1179 bits (3049), Expect = 0.0
 Identities = 589/589 (100%), Positives = 589/589 (100%)

Query: 44  GSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHED 103
           GSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHED
Sbjct: 18  GSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHED 77

Query: 104 DVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAK 163
           DVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAK
Sbjct: 78  DVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAK 137

Query: 164 QGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSAN 223
           QGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSAN
Sbjct: 138 QGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSAN 197

Query: 224 SVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHR 283
           SVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHR
Sbjct: 198 SVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHR 257

Query: 284 FEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLV 343
           FEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLV
Sbjct: 258 FEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLV 317

Query: 344 VLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQ 403
           VLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQ
Sbjct: 318 VLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQ 377

Query: 404 CPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTL 463
           CPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTL
Sbjct: 378 CPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTL 437

Query: 464 ASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSR 523
           ASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSR
Sbjct: 438 ASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSR 497

Query: 524 QETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRD 583
           QETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRD
Sbjct: 498 QETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRD 557

Query: 584 VDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ 632
           VDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ
Sbjct: 558 VDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ 606


>gi|147904948 calcium channel, voltage-dependent, beta 2 subunit
           isoform 8 [Homo sapiens]
          Length = 608

 Score = 1155 bits (2989), Expect = 0.0
 Identities = 591/632 (93%), Positives = 594/632 (93%), Gaps = 24/632 (3%)

Query: 1   MNQGSGLDLLKISYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSL 60
           MNQGSGLDLLKISYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSL
Sbjct: 1   MNQGSGLDLLKISYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSL 60

Query: 61  EEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFL 120
           EEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFL
Sbjct: 61  EEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFL 120

Query: 121 HVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSL 180
           HVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSL
Sbjct: 121 HVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSL 180

Query: 181 GDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKK 240
           GDIVPSSRKSTPPSS          A+E D                    K   + +   
Sbjct: 181 GDIVPSSRKSTPPSSGAK------SADEQD------------------QWKTAGLFWRFT 216

Query: 241 TEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLA 300
           TEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLA
Sbjct: 217 TEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLA 276

Query: 301 KRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTS 360
           KRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTS
Sbjct: 277 KRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTS 336

Query: 361 LAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLED 420
           LAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLED
Sbjct: 337 LAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLED 396

Query: 421 ACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSA 480
           ACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSA
Sbjct: 397 ACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSA 456

Query: 481 PIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYV 540
           PIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYV
Sbjct: 457 PIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYV 516

Query: 541 EPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRH 600
           EPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRH
Sbjct: 517 EPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRH 576

Query: 601 KSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ 632
           KSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ
Sbjct: 577 KSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ 608


>gi|147901383 calcium channel, voltage-dependent, beta 2 subunit
           isoform 5 [Homo sapiens]
          Length = 622

 Score = 1134 bits (2933), Expect = 0.0
 Identities = 579/620 (93%), Positives = 581/620 (93%), Gaps = 38/620 (6%)

Query: 13  SYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAE 72
           SYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAE
Sbjct: 41  SYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAE 100

Query: 73  RQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWI 132
           RQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWI
Sbjct: 101 RQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWI 160

Query: 133 GRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTP 192
           GRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTP
Sbjct: 161 GRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTP 220

Query: 193 PSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPS 252
           PSSA                                  K+K+    K TEHTPPYDVVPS
Sbjct: 221 PSSA----------------------------------KQKQ----KSTEHTPPYDVVPS 242

Query: 253 MRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHA 312
           MRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHA
Sbjct: 243 MRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHA 302

Query: 313 IIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISS 372
           IIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISS
Sbjct: 303 IIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISS 362

Query: 373 PKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAY 432
           PKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAY
Sbjct: 363 PKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAY 422

Query: 433 WKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEP 492
           WKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEP
Sbjct: 423 WKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEP 482

Query: 493 SVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVD 552
           SVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVD
Sbjct: 483 SVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVD 542

Query: 553 HYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGE 612
           HYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGE
Sbjct: 543 HYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGE 602

Query: 613 VISKKRNEAGEWNRDVYIRQ 632
           VISKKRNEAGEWNRDVYIRQ
Sbjct: 603 VISKKRNEAGEWNRDVYIRQ 622


>gi|45359842 calcium channel, voltage-dependent, beta 2 subunit
           isoform 4 [Homo sapiens]
          Length = 636

 Score = 1133 bits (2930), Expect = 0.0
 Identities = 579/620 (93%), Positives = 582/620 (93%), Gaps = 24/620 (3%)

Query: 13  SYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAE 72
           SYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAE
Sbjct: 41  SYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAE 100

Query: 73  RQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWI 132
           RQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWI
Sbjct: 101 RQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWI 160

Query: 133 GRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTP 192
           GRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTP
Sbjct: 161 GRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTP 220

Query: 193 PSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPS 252
           PSS          A+E D                    K   + +   TEHTPPYDVVPS
Sbjct: 221 PSSGAK------SADEQD------------------QWKTAGLFWRFTTEHTPPYDVVPS 256

Query: 253 MRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHA 312
           MRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHA
Sbjct: 257 MRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHA 316

Query: 313 IIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISS 372
           IIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISS
Sbjct: 317 IIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISS 376

Query: 373 PKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAY 432
           PKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAY
Sbjct: 377 PKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAY 436

Query: 433 WKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEP 492
           WKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEP
Sbjct: 437 WKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEP 496

Query: 493 SVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVD 552
           SVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVD
Sbjct: 497 SVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVD 556

Query: 553 HYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGE 612
           HYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGE
Sbjct: 557 HYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGE 616

Query: 613 VISKKRNEAGEWNRDVYIRQ 632
           VISKKRNEAGEWNRDVYIRQ
Sbjct: 617 VISKKRNEAGEWNRDVYIRQ 636


>gi|40804468 calcium channel, voltage-dependent, beta 1 subunit
           isoform 1 [Homo sapiens]
          Length = 598

 Score =  726 bits (1874), Expect = 0.0
 Identities = 393/621 (63%), Positives = 456/621 (73%), Gaps = 55/621 (8%)

Query: 15  GKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQ 74
           GK ++RK RFK SDGSTSSDTTSNSFVRQGSA+SYTSRPSDSDVSLEEDREA+R+EAERQ
Sbjct: 29  GKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQ 88

Query: 75  AQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGR 134
           A AQLEKAKTKPVAFAVRTNV Y+ +  D+VPV G+AI+FE KDFLH+KEK+NNDWWIGR
Sbjct: 89  ALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGR 148

Query: 135 LVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPS 194
           LVKEGCE+GFIPSPVKL+++RL  EQ+ +Q +  SSKSG NSSSSLGD+V  +R+ TPP+
Sbjct: 149 LVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNRLGSSKSGDNSSSSLGDVVTGTRRPTPPA 208

Query: 195 SAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMR 254
           SA                                  K+K+    K TEH PPYDVVPSMR
Sbjct: 209 SA----------------------------------KQKQ----KSTEHVPPYDVVPSMR 230

Query: 255 PVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAII 314
           P++LVGPSLKGYEVTDMMQKALFDFLKHRF+GRISITRVTADISLAKRSVLNNPSKH II
Sbjct: 231 PIILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIII 290

Query: 315 ERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPK 374
           ERSNTRSSLAEVQSEIERIFELARTLQLV LDADTINHPAQLSKTSLAPIIVY+KI+SPK
Sbjct: 291 ERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPK 350

Query: 375 VLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWK 434
           VLQRLIKSRGKSQ+KHLNVQ+ A++KLAQCPPE+FD+ILDENQLEDACEHLA+YLEAYWK
Sbjct: 351 VLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWK 410

Query: 435 ATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQG---SQGDQRTDRSAPIRSASQAEEE 491
           ATHPPSS+ PNPLL+RT+AT++L  SP   SN QG   + GDQ      P+  A+     
Sbjct: 411 ATHPPSSTPPNPLLNRTMATAALAASPAPVSNLQGPYLASGDQ------PLERATGEHAS 464

Query: 492 PSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHV 551
               P +  Q      + H   R+GT R LSRQ+TFD++T  SR+SAY E         V
Sbjct: 465 MHEYPGELGQPPGLYPSSHPPGRAGTLRALSRQDTFDADTPGSRNSAYTE----LGDSCV 520

Query: 552 DHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYC-EKD 610
           D      +     +  G      R+      + D E+   E    R+R ++K RYC E  
Sbjct: 521 DMETDPSEGPGLGDPAGGGTPPARQGSWEDEEEDYEE---ELTDNRNRGRNKARYCAEGG 577

Query: 611 GEVISKKRNEAGEWNRDVYIR 631
           G V+ + +NE   W R VYIR
Sbjct: 578 GPVLGRNKNELEGWGRGVYIR 598


>gi|40804470 calcium channel, voltage-dependent, beta 1 subunit
           isoform 2 [Homo sapiens]
          Length = 523

 Score =  711 bits (1834), Expect = 0.0
 Identities = 357/461 (77%), Positives = 405/461 (87%), Gaps = 7/461 (1%)

Query: 15  GKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQ 74
           GK ++RK RFK SDGSTSSDTTSNSFVRQGSA+SYTSRPSDSDVSLEEDREA+R+EAERQ
Sbjct: 29  GKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQ 88

Query: 75  AQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGR 134
           A AQLEKAKTKPVAFAVRTNV Y+ +  D+VPV G+AI+FE KDFLH+KEK+NNDWWIGR
Sbjct: 89  ALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGR 148

Query: 135 LVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPS 194
           LVKEGCE+GFIPSPVKL+++RL  EQ+ +Q +  SSKSG NSSSSLGD+V  +R+ TPP+
Sbjct: 149 LVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNRLGSSKSGDNSSSSLGDVVTGTRRPTPPA 208

Query: 195 S-------AIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPY 247
           S       A ++D   L+ EE ++     S K S +SVT+P    KR+PFFKKTEH PPY
Sbjct: 209 SGNEMTNLAFELDPLELEEEEAELGEQSGSAKTSVSSVTTPPPHGKRIPFFKKTEHVPPY 268

Query: 248 DVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNN 307
           DVVPSMRP++LVGPSLKGYEVTDMMQKALFDFLKHRF+GRISITRVTADISLAKRSVLNN
Sbjct: 269 DVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNN 328

Query: 308 PSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVY 367
           PSKH IIERSNTRSSLAEVQSEIERIFELARTLQLV LDADTINHPAQLSKTSLAPIIVY
Sbjct: 329 PSKHIIIERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVY 388

Query: 368 VKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLAD 427
           +KI+SPKVLQRLIKSRGKSQ+KHLNVQ+ A++KLAQCPPE+FD+ILDENQLEDACEHLA+
Sbjct: 389 IKITSPKVLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAE 448

Query: 428 YLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQ 468
           YLEAYWKATHPPSS+ PNPLL+RT+AT++L  SP   SN Q
Sbjct: 449 YLEAYWKATHPPSSTPPNPLLNRTMATAALAASPAPVSNLQ 489


>gi|40804472 calcium channel, voltage-dependent, beta 1 subunit
           isoform 3 [Homo sapiens]
          Length = 478

 Score =  669 bits (1726), Expect = 0.0
 Identities = 342/454 (75%), Positives = 384/454 (84%), Gaps = 38/454 (8%)

Query: 15  GKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQ 74
           GK ++RK RFK SDGSTSSDTTSNSFVRQGSA+SYTSRPSDSDVSLEEDREA+R+EAERQ
Sbjct: 29  GKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQ 88

Query: 75  AQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGR 134
           A AQLEKAKTKPVAFAVRTNV Y+ +  D+VPV G+AI+FE KDFLH+KEK+NNDWWIGR
Sbjct: 89  ALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGR 148

Query: 135 LVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPS 194
           LVKEGCE+GFIPSPVKL+++RL  EQ+ +Q +  SSKSG NSSSSLGD+V  +R+ TPP+
Sbjct: 149 LVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNRLGSSKSGDNSSSSLGDVVTGTRRPTPPA 208

Query: 195 SAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMR 254
           SA                                  K+K+    K TEH PPYDVVPSMR
Sbjct: 209 SA----------------------------------KQKQ----KSTEHVPPYDVVPSMR 230

Query: 255 PVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAII 314
           P++LVGPSLKGYEVTDMMQKALFDFLKHRF+GRISITRVTADISLAKRSVLNNPSKH II
Sbjct: 231 PIILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIII 290

Query: 315 ERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPK 374
           ERSNTRSSLAEVQSEIERIFELARTLQLV LDADTINHPAQLSKTSLAPIIVY+KI+SPK
Sbjct: 291 ERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPK 350

Query: 375 VLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWK 434
           VLQRLIKSRGKSQ+KHLNVQ+ A++KLAQCPPE+FD+ILDENQLEDACEHLA+YLEAYWK
Sbjct: 351 VLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWK 410

Query: 435 ATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQ 468
           ATHPPSS+ PNPLL+RT+AT++L  SP   SN Q
Sbjct: 411 ATHPPSSTPPNPLLNRTMATAALAASPAPVSNLQ 444


>gi|54607066 calcium channel, voltage-dependent, beta 4 subunit
           isoform c [Homo sapiens]
          Length = 502

 Score =  631 bits (1628), Expect = 0.0
 Identities = 353/562 (62%), Positives = 409/562 (72%), Gaps = 72/562 (12%)

Query: 20  RKNRFKGSDGSTSSDTTSNSFV-RQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQ 78
           R++R K SDGST    TS SF+ RQGSADSYTSRPSDSDVSLEEDREA+R+E E+QA  Q
Sbjct: 11  RRSRLKRSDGST----TSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQ 66

Query: 79  LEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKE 138
           LE+AK+KPVAFAV+TNVSY  A ++DVPVP  AISF+AKDFLH+KEK+NNDWWIGRLVKE
Sbjct: 67  LERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKE 126

Query: 139 GCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAID 198
           GCEIGFIPSP++LEN+R+Q EQ  K+G+F+  KS GNSSSSLG++V  + ++TP S+A  
Sbjct: 127 GCEIGFIPSPLRLENIRIQQEQ--KRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTA-- 182

Query: 199 IDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVL 258
                                           K+K+    K TEH PPYDVVPSMRPVVL
Sbjct: 183 --------------------------------KQKQ----KVTEHIPPYDVVPSMRPVVL 206

Query: 259 VGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSN 318
           VGPSLKGYEVTDMMQKALFDFLKHRF+GRISITRVTADISLAKRSVLNNPSK AIIERSN
Sbjct: 207 VGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSN 266

Query: 319 TRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQR 378
           TRSSLAEVQSEIERIFELAR+LQLVVLDADTINHPAQL KTSLAPIIV+VK+SSPKVLQR
Sbjct: 267 TRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQR 326

Query: 379 LIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHP 438
           LIKSRGKSQ+KHLNVQ+VAADKLAQCPPE+FDVILDENQLEDACEHL +YLEAYW+ATH 
Sbjct: 327 LIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHT 386

Query: 439 PSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVK 498
            SS+   PLL R L +++L   PT  S  Q          S  +R ++ + E   +E   
Sbjct: 387 TSSTPMTPLLGRNLGSTALSPYPTAISGLQ----------SQRMRHSNHSTENSPIE--- 433

Query: 499 KSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHR 558
             +   +S   +HN R+  SR         S +Q SRD  Y   +EDY   + D Y  HR
Sbjct: 434 -RRSLMTSDENYHNERARKSR-----NRLSSSSQHSRDH-YPLVEEDYPDSYQDTYKPHR 486

Query: 559 DHNHRDETHGSSDHRHRESRHR 580
           +        GS      +SRHR
Sbjct: 487 N-------RGSPGGYSHDSRHR 501


>gi|54607064 calcium channel, voltage-dependent, beta 4 subunit
           isoform b [Homo sapiens]
          Length = 520

 Score =  631 bits (1628), Expect = 0.0
 Identities = 353/562 (62%), Positives = 409/562 (72%), Gaps = 72/562 (12%)

Query: 20  RKNRFKGSDGSTSSDTTSNSFV-RQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQ 78
           R++R K SDGST    TS SF+ RQGSADSYTSRPSDSDVSLEEDREA+R+E E+QA  Q
Sbjct: 29  RRSRLKRSDGST----TSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQ 84

Query: 79  LEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKE 138
           LE+AK+KPVAFAV+TNVSY  A ++DVPVP  AISF+AKDFLH+KEK+NNDWWIGRLVKE
Sbjct: 85  LERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKE 144

Query: 139 GCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAID 198
           GCEIGFIPSP++LEN+R+Q EQ  K+G+F+  KS GNSSSSLG++V  + ++TP S+A  
Sbjct: 145 GCEIGFIPSPLRLENIRIQQEQ--KRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTA-- 200

Query: 199 IDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVL 258
                                           K+K+    K TEH PPYDVVPSMRPVVL
Sbjct: 201 --------------------------------KQKQ----KVTEHIPPYDVVPSMRPVVL 224

Query: 259 VGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSN 318
           VGPSLKGYEVTDMMQKALFDFLKHRF+GRISITRVTADISLAKRSVLNNPSK AIIERSN
Sbjct: 225 VGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSN 284

Query: 319 TRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQR 378
           TRSSLAEVQSEIERIFELAR+LQLVVLDADTINHPAQL KTSLAPIIV+VK+SSPKVLQR
Sbjct: 285 TRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQR 344

Query: 379 LIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHP 438
           LIKSRGKSQ+KHLNVQ+VAADKLAQCPPE+FDVILDENQLEDACEHL +YLEAYW+ATH 
Sbjct: 345 LIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHT 404

Query: 439 PSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVK 498
            SS+   PLL R L +++L   PT  S  Q          S  +R ++ + E   +E   
Sbjct: 405 TSSTPMTPLLGRNLGSTALSPYPTAISGLQ----------SQRMRHSNHSTENSPIE--- 451

Query: 499 KSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHR 558
             +   +S   +HN R+  SR         S +Q SRD  Y   +EDY   + D Y  HR
Sbjct: 452 -RRSLMTSDENYHNERARKSR-----NRLSSSSQHSRDH-YPLVEEDYPDSYQDTYKPHR 504

Query: 559 DHNHRDETHGSSDHRHRESRHR 580
           +        GS      +SRHR
Sbjct: 505 N-------RGSPGGYSHDSRHR 519


>gi|54607068 calcium channel, voltage-dependent, beta 4 subunit
           isoform a [Homo sapiens]
          Length = 486

 Score =  613 bits (1582), Expect = e-175
 Identities = 339/537 (63%), Positives = 392/537 (72%), Gaps = 67/537 (12%)

Query: 44  GSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHED 103
           GSADSYTSRPSDSDVSLEEDREA+R+E E+QA  QLE+AK+KPVAFAV+TNVSY  A ++
Sbjct: 16  GSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDE 75

Query: 104 DVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAK 163
           DVPVP  AISF+AKDFLH+KEK+NNDWWIGRLVKEGCEIGFIPSP++LEN+R+Q EQ  K
Sbjct: 76  DVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQ--K 133

Query: 164 QGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSAN 223
           +G+F+  KS GNSSSSLG++V  + ++TP S+A                           
Sbjct: 134 RGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTA--------------------------- 166

Query: 224 SVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHR 283
                  K+K+    K TEH PPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHR
Sbjct: 167 -------KQKQ----KVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHR 215

Query: 284 FEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLV 343
           F+GRISITRVTADISLAKRSVLNNPSK AIIERSNTRSSLAEVQSEIERIFELAR+LQLV
Sbjct: 216 FDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLV 275

Query: 344 VLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQ 403
           VLDADTINHPAQL KTSLAPIIV+VK+SSPKVLQRLIKSRGKSQ+KHLNVQ+VAADKLAQ
Sbjct: 276 VLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQ 335

Query: 404 CPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTL 463
           CPPE+FDVILDENQLEDACEHL +YLEAYW+ATH  SS+   PLL R L +++L   PT 
Sbjct: 336 CPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTA 395

Query: 464 ASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSR 523
            S  Q          S  +R ++ + E   +E     +   +S   +HN R+  SR    
Sbjct: 396 ISGLQ----------SQRMRHSNHSTENSPIE----RRSLMTSDENYHNERARKSR---- 437

Query: 524 QETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHR 580
                S +Q SRD  Y   +EDY   + D Y  HR+        GS      +SRHR
Sbjct: 438 -NRLSSSSQHSRDH-YPLVEEDYPDSYQDTYKPHRN-------RGSPGGYSHDSRHR 485


>gi|224831262 calcium channel, voltage-dependent, beta 4 subunit
           isoform d [Homo sapiens]
          Length = 458

 Score =  534 bits (1376), Expect = e-152
 Identities = 318/562 (56%), Positives = 367/562 (65%), Gaps = 134/562 (23%)

Query: 20  RKNRFKGSDGSTSSDTTSNSFV-RQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQ 78
           R++R K SDGST    TS SF+ RQGSADSYTSRPSDSDVSLEEDREA+R+E E+QA  Q
Sbjct: 29  RRSRLKRSDGST----TSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQ 84

Query: 79  LEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKE 138
           LE+AK+KPVAFAV+TNVSY  A ++DVPVP  AISF+AKDFLH+KEK+NNDWWIGRLVKE
Sbjct: 85  LERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKE 144

Query: 139 GCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAID 198
           GCEIGFIPSP++LEN+R+Q EQ  K+G+F+  KS GNSSSSLG++V  + ++TP S+A  
Sbjct: 145 GCEIGFIPSPLRLENIRIQQEQ--KRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTA-- 200

Query: 199 IDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVL 258
                                           K+K+    K TEH PPYDVVPSMRPVVL
Sbjct: 201 --------------------------------KQKQ----KVTEHIPPYDVVPSMRPVVL 224

Query: 259 VGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSN 318
           VGPSLKGYEVTDMMQKALFDFLKHRF+GRISITRVTADISLAKRSVLNNPSK AIIERSN
Sbjct: 225 VGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSN 284

Query: 319 TRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQR 378
           TRSSLAEVQSEIERIFELAR+LQLVVLDADTINHPAQL KTSLAPIIV+VK+SSPKVLQR
Sbjct: 285 TRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQR 344

Query: 379 LIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHP 438
           LIKSRGKSQ+KHLNVQ+VAADKLAQCPP                           +  H 
Sbjct: 345 LIKSRGKSQSKHLNVQLVAADKLAQCPPS-------------------------QRMRHS 379

Query: 439 PSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVK 498
             S+  +P+  R+L TS                                 +E    E  +
Sbjct: 380 NHSTENSPIERRSLMTS---------------------------------DENYHNERAR 406

Query: 499 KSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHR 558
           KS++R SSS+ H                       SRD  Y   +EDY   + D Y  HR
Sbjct: 407 KSRNRLSSSSQH-----------------------SRDH-YPLVEEDYPDSYQDTYKPHR 442

Query: 559 DHNHRDETHGSSDHRHRESRHR 580
           +        GS      +SRHR
Sbjct: 443 N-------RGSPGGYSHDSRHR 457


>gi|40316928 calcium channel, voltage-dependent, beta 3 subunit
           [Homo sapiens]
          Length = 484

 Score =  533 bits (1373), Expect = e-151
 Identities = 312/565 (55%), Positives = 367/565 (64%), Gaps = 98/565 (17%)

Query: 44  GSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHE 102
           GSADSYTSRPS DSDVSLEEDRE+ RRE E QAQ QLE+AK KPVAFAVRTNVSY    +
Sbjct: 16  GSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLD 75

Query: 103 DDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRA 162
           ++ PV G  ++FEAKDFLH+KEK++NDWWIGRLVKEG +I FIPSP +LE++RL+ EQ+A
Sbjct: 76  EECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKA 135

Query: 163 KQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSA 222
                                    R+S  PSS  DI              N RSP PS 
Sbjct: 136 -------------------------RRSGNPSSLSDI-------------GNRRSPPPSL 157

Query: 223 NSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKH 282
                  +K+K+    K+ EH PPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKH
Sbjct: 158 -------AKQKQ----KQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKH 206

Query: 283 RFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQL 342
           RF+GRISITRVTAD+SLAKRSVLNNP K  IIERS+ RSS+AEVQSEIERIFELA++LQL
Sbjct: 207 RFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQL 266

Query: 343 VVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLA 402
           VVLDADTINHPAQL+KTSLAPIIV+VK+SSPKVLQRLI+SRGKSQ KHL VQM+A DKL 
Sbjct: 267 VVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLV 326

Query: 403 QCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNP-LLSRTLATSSLPLSP 461
           QCPPE FDVILDENQLEDACEHLA+YLE YW+ATH P+   P P LL    A   L    
Sbjct: 327 QCPPESFDVILDENQLEDACEHLAEYLEVYWRATHHPA---PGPGLLGPPSAIPGLQNQQ 383

Query: 462 TLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGL 521
            L     G +G++ +                   P+++     S  A   + ++ T    
Sbjct: 384 LL-----GERGEEHS-------------------PLERDSLMPSDEASESSRQAWTG--- 416

Query: 522 SRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRS 581
                        R S ++E  EDY+  + D Y  HR H     T G       + + R 
Sbjct: 417 ----------SSQRSSRHLE--EDYADAYQDLYQPHRQH-----TSGLPSANGHDPQDRL 459

Query: 582 RDVDREQDHNECNKQRSRHKSKDRY 606
              D E +H++ N QR+R   KD Y
Sbjct: 460 LAQDSEHNHSDRNWQRNRPWPKDSY 484


>gi|50962882 G patch domain containing 8 [Homo sapiens]
          Length = 1502

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 49/182 (26%), Positives = 74/182 (40%), Gaps = 30/182 (16%)

Query: 467 SQGSQGDQRTDRSAPIR----SASQAEEEPSVEP--VKKSQHRSSSSAPHHNHRSGTSRG 520
           SQ S GD+ +D ++  R    S SQ  EE   E    + S+ RS S   H +HRS     
Sbjct: 811 SQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSS---- 866

Query: 521 LSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYA------SHRDHNHRDETHGSSDHRH 574
              + ++ S +  S D +    +  YS D    Y+      S R H+  D  + SS HR 
Sbjct: 867 ---RRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRS 923

Query: 575 RESRHRSRDVD----------REQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEW 624
           +  ++ S D D          R + H    + RSR +S+   C +       +   A  W
Sbjct: 924 KRHKYSSSDDDYSLSCSQSRSRSRSHTR-ERSRSRGRSRSSSCSRSRSKRRSRSTTAHSW 982

Query: 625 NR 626
            R
Sbjct: 983 QR 984



 Score = 33.1 bits (74), Expect = 0.80
 Identities = 36/146 (24%), Positives = 55/146 (37%), Gaps = 8/146 (5%)

Query: 465 SNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQ 524
           S S+   G + +   +  RS S + +  S +    S+ RS S   + ++   + R   R 
Sbjct: 850 SRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCY-SRQRSYSDDSYSDYSDRSRRHSKRS 908

Query: 525 ETFD-----SETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRH 579
              D     S    S+   Y    +DYS       +  R  +H  E   S       S  
Sbjct: 909 HDSDDSDYASSKHRSKRHKYSSSDDDYSLS--CSQSRSRSRSHTRERSRSRGRSRSSSCS 966

Query: 580 RSRDVDREQDHNECNKQRSRHKSKDR 605
           RSR   R +     + QRSR  S+DR
Sbjct: 967 RSRSKRRSRSTTAHSWQRSRSYSRDR 992


>gi|119943108 synapse-associated protein 102 isoform b [Homo
           sapiens]
          Length = 512

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 75/345 (21%), Positives = 136/345 (39%), Gaps = 45/345 (13%)

Query: 104 DVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVK---EGCEIGFIPSPVKLENMRLQHEQ 160
           D  +P   +SF   D LHV    +++WW  RLV    E  +IG IPS  ++E    +   
Sbjct: 180 DSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEK---KERA 236

Query: 161 RAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLD-AEENDIPANHRSPK 219
           R K  KF++      S+ S   I    +KS   S       +  + A+E+ I     +  
Sbjct: 237 RLKTVKFHARTGMIESNRS---IKTKRKKSFRLSRKFPFYKSKENMAQESSIQEQGVTSN 293

Query: 220 PSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDF 279
            S +  +S   ++  + +   T     Y      RPV+++GP      + D +   L   
Sbjct: 294 TSDSESSSKGQEDAILSYEPVTRQEIHY-----ARPVIILGP------MKDRVNDDLISE 342

Query: 280 LKHRFEGRI-SITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQ----------- 327
             H+F   +   TR   D      + ++    H ++ R      + + +           
Sbjct: 343 FPHKFGSCVPHTTRPRRD------NEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNL 396

Query: 328 --SEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGK 385
             + I+ +  +A   +  +LD    N   +L +  L PI +++K   PK ++ L++   +
Sbjct: 397 YGTSIQSVRAVAERGKHCILDVSG-NAIKRLQQAQLYPIAIFIK---PKSIEALMEMNRR 452

Query: 386 SQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLE 430
              +  N     A KL Q   E F  I+  + LE+    +   +E
Sbjct: 453 QTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIE 497


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 71/340 (20%), Positives = 131/340 (38%), Gaps = 38/340 (11%)

Query: 104 DVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVK---EGCEIGFIPSPVKLENMRLQHEQ 160
           D  +P   ++F+  D LHV    +++WW  R V    E  E+G IPS  ++E    +   
Sbjct: 597 DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEK---KERA 653

Query: 161 RAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKP 220
           R K  KF S       +   G      RK    S           +E+    A+      
Sbjct: 654 RLKTVKFNS------KTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSN 707

Query: 221 SANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFL 280
           +++S +S   +E+ +  ++          V   RPV+++GP      + D +   L    
Sbjct: 708 ASDSESSYRGQEEYVLSYEPVNQ----QEVNYTRPVIILGP------MKDRINDDLISEF 757

Query: 281 KHRFEGRI-SITRVTADISL---------AKRSVLNNPSKHAIIERSNTRSSLAEVQSEI 330
             +F   +   TR   D  +         ++  +  +  +H  IE     + L    + +
Sbjct: 758 PDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHL--YGTSV 815

Query: 331 ERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKH 390
           + + E+A   +  +LD    N   +L    L PI +++K   PK ++ +++   +   + 
Sbjct: 816 QSVREVAEKGKHCILDVSG-NAIKRLQIAQLYPISIFIK---PKSMENIMEMNKRLTEEQ 871

Query: 391 LNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLE 430
                  A KL Q   E F  I+  + LED    +   +E
Sbjct: 872 ARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIE 911


>gi|4504487 histidine rich calcium binding protein precursor [Homo
           sapiens]
          Length = 699

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 41/148 (27%), Positives = 60/148 (40%), Gaps = 9/148 (6%)

Query: 486 SQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAY--VEPK 543
           S  + E   E V K            +H+ G   G+S +E F     ++R       E  
Sbjct: 84  SHPDREKEDEDVSKEYGHLLPGHRSQDHKVG-DEGVSGEEVFAEHGGQARGHRGHGSEDT 142

Query: 544 EDYSHDHVDHYASHRDHNHRDETHG---SSDHRHRESRHRSRDVDREQDHNECNKQRSRH 600
           ED S +H  H  SHR H+H+DE      SS+H H   RH  R  D E D  E  ++    
Sbjct: 143 ED-SAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGE--EEEEEE 199

Query: 601 KSKDRYCEKDGEVISKKRNEAGEWNRDV 628
           + ++    + G    + R    E + DV
Sbjct: 200 EEEEEASTEYGHQAHRHRGHGSEEDEDV 227



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 33/141 (23%), Positives = 53/141 (37%), Gaps = 16/141 (11%)

Query: 473 DQRTDRSAPIRSASQAEEEPSVEPVKKS-QHRSSSS------APHHNHRSGTSRGLSRQE 525
           D   D         + EEE S E   ++ +HR   S      +  H+H   + R    +E
Sbjct: 186 DGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEE 245

Query: 526 TFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSR--- 582
             D +  +  D    +  +D S ++      H+ H   ++   S  H HR+  HR R   
Sbjct: 246 DDDDDDDDDDD----DDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHE 301

Query: 583 --DVDREQDHNECNKQRSRHK 601
             D D +    E   Q  RH+
Sbjct: 302 EDDNDDDDVSTEYGHQAHRHQ 322



 Score = 33.5 bits (75), Expect = 0.61
 Identities = 23/100 (23%), Positives = 37/100 (37%), Gaps = 6/100 (6%)

Query: 511 HNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSS 570
           H+HR  + R  S +E  + +   S +  +       +H H DH     +    +  H   
Sbjct: 288 HHHRDPSHRHRSHEEDDNDDDDVSTEYGH------QAHRHQDHRKEEVEAVSGEHHHHVP 341

Query: 571 DHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKD 610
           DHRH+  R    D D   +      Q   H   D   E++
Sbjct: 342 DHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEE 381



 Score = 30.8 bits (68), Expect = 4.0
 Identities = 25/126 (19%), Positives = 48/126 (38%), Gaps = 8/126 (6%)

Query: 480 APIRSASQAEEEPSVEPVKKSQHRSSSSAPHH--NHRSGTSRGLSRQETFDSETQESRDS 537
           AP    S  +EE         Q  S     HH   H     R   R++  + E ++  D 
Sbjct: 438 APSHRQSHQDEETG-----HGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDP 492

Query: 538 AYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQR 597
              E ++D S +  +    H   +  DE      H    ++    + D+E++  E +++R
Sbjct: 493 GSHE-EDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEER 551

Query: 598 SRHKSK 603
              +++
Sbjct: 552 REERAE 557


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 47/177 (26%), Positives = 68/177 (38%), Gaps = 17/177 (9%)

Query: 439 PSSSLPNPLLSRTLATSSLPLSPTLASN---SQGSQGDQRTDRSAPI------RSASQAE 489
           P    P PLL+     S  PL+ T  S    +  S+     DRS P       +S+S   
Sbjct: 361 PEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSES 420

Query: 490 EEPSVEPVKKSQHRSSS-SAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSH 548
             PS +P K S+H SSS  +P      G+ R +S   T       S++ ++   K D SH
Sbjct: 421 SPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPT-------SKNRSHGRAKRDKSH 473

Query: 549 DHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDR 605
            H       R  +      G S  R    R  SR    +   +   ++  R +S  R
Sbjct: 474 SHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQR 530



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 30/136 (22%), Positives = 56/136 (41%), Gaps = 11/136 (8%)

Query: 439 PSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVK 498
           P+   P P      ++SS   +P      +     +R++ S+P R   ++         K
Sbjct: 163 PAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSS--------K 214

Query: 499 KSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHR 558
           K +HRS S +    HRS T +  S++++ D + + SR S    PK   +H      ++  
Sbjct: 215 KKKHRSESESKKRKHRSPTPK--SKRKSKDKKRKRSR-STTPAPKSRRAHRSTSADSASS 271

Query: 559 DHNHRDETHGSSDHRH 574
               R  +  ++   H
Sbjct: 272 SDTSRSRSRSAAAKTH 287



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 42/187 (22%), Positives = 69/187 (36%), Gaps = 21/187 (11%)

Query: 439  PSSSLPNPLLSRTLA-TSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPV 497
            P +  P  L  R+ + +SS    P+   +S      +   +S   R  S++  EP  +  
Sbjct: 1624 PKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSR 1683

Query: 498  KKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSET--------QESRDSAYVEPKEDYSHD 549
               + RSS S+P    ++  SR  SR  +   ET        + S   +  EP E     
Sbjct: 1684 TPPRRRSSRSSPELTRKARLSR-RSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSS 1742

Query: 550  HVDHYA--------SHRDHNHRDETHGSSDHRHRESRHRSRDV---DREQDHNECNKQRS 598
                 A        S R  +   +  G    R R  R ++R     DR       +++R 
Sbjct: 1743 RRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQ 1802

Query: 599  RHKSKDR 605
            R +S+ R
Sbjct: 1803 RSRSRSR 1809



 Score = 33.1 bits (74), Expect = 0.80
 Identities = 28/119 (23%), Positives = 41/119 (34%)

Query: 137  KEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSA 196
            KE    G  P P   +  R      +      SS S  +SSSS      SS  S+  SS+
Sbjct: 2587 KEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2646

Query: 197  IDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRP 255
                      +    PA+ + P P      SP      +   +   ++P     PS +P
Sbjct: 2647 SSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQP 2705



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 28/93 (30%), Positives = 40/93 (43%), Gaps = 18/93 (19%)

Query: 440 SSSLPNPLLSRTLATSSLPLSPTLASNS---------------QGSQGDQRTDRSAPIRS 484
           S SL +P   R+ A S L L  +L+ +S                GS   +   R+ P RS
Sbjct: 759 SRSLSSP---RSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRS 815

Query: 485 ASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGT 517
            S +   P  +    S+   SSS+PH   +SGT
Sbjct: 816 RSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGT 848



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 38/154 (24%), Positives = 59/154 (38%), Gaps = 14/154 (9%)

Query: 460  SPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGT-- 517
            SP    +S+ S   +R     P  S  ++    S  P K+S+ R +S A H   RS T  
Sbjct: 1824 SPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSR-ASPATHRRSRSRTPL 1882

Query: 518  -SRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNH-----RDETHGSSD 571
             SR  SR  T     + SR    V  +   S       +  R  +      R  +   + 
Sbjct: 1883 ISRRRSRSRTSPVSRRRSRSRTSVTRRR--SRSRASPVSRRRSRSRTPPVTRRRSRSRTP 1940

Query: 572  HRHRESRHRSRDVDREQDHNE---CNKQRSRHKS 602
               R SR R+  V R +  +      ++RSR ++
Sbjct: 1941 TTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRT 1974



 Score = 30.0 bits (66), Expect = 6.8
 Identities = 28/120 (23%), Positives = 47/120 (39%), Gaps = 16/120 (13%)

Query: 435  ATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIR---------SA 485
            A  P      +   S + ++SS   S + +S+S GS        S P++         S 
Sbjct: 2523 ALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSP 2582

Query: 486  SQAEEE-------PSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSA 538
            + A +E       P   P K+ +  SSSS+   +  S +S   S   +  S +  S  S+
Sbjct: 2583 TPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2642


>gi|9945320 cyclin L1 [Homo sapiens]
          Length = 526

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 36/142 (25%), Positives = 62/142 (43%), Gaps = 16/142 (11%)

Query: 464 ASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSR 523
           AS S  +   + + RS   RSAS++          +S+ RS +   H+N+R       SR
Sbjct: 371 ASKSPYNGVRKDSKRSRNSRSASRSRSRT------RSRSRSHTPRRHYNNRR------SR 418

Query: 524 QETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRD 583
             T+ S ++    S    P+  ++H      A H     RD+   S+ H H+  + RSR 
Sbjct: 419 SGTYSSRSRSRSRSHSESPRRHHNHGSPHLKAKHT----RDDLKSSNRHGHKRKKSRSRS 474

Query: 584 VDREQDHNECNKQRSRHKSKDR 605
             + +DH++  K+    +   R
Sbjct: 475 QSKSRDHSDAAKKHRHERGHHR 496


>gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo
           sapiens]
          Length = 434

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 38/151 (25%), Positives = 64/151 (42%), Gaps = 12/151 (7%)

Query: 488 AEEEPSVEPVKKSQHRSSSSAPHHN-HRSGTSRGLSRQETFDSETQESRDSAYVEPKEDY 546
           A E+ S +  KK +    S +P  + H    SR  SR+    S+ +  +  +    KE  
Sbjct: 12  APEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGR 71

Query: 547 SHDHVDHYA-SHRDHNHRDETHGSSDHRHR-------ESRH--RSRDVDREQDHNECNKQ 596
            H+  D  +  H+   H D+ H S   R R       E RH  + R   R + H+    +
Sbjct: 72  RHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSR 131

Query: 597 RSRHKSKDRYCEKDGEVISKKRNEAGEWNRD 627
             RH+S+ R   K     S++R ++   +R+
Sbjct: 132 ERRHRSRSRE-RKKSRSRSRERKKSRSRSRE 161



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 39/177 (22%), Positives = 72/177 (40%), Gaps = 28/177 (15%)

Query: 477 DRSAPIRSASQAEEEPSVEPVKKSQH-------------RSSSSAPHHNHRSGTSRGLSR 523
           ++++P R   + + E SV P     H             +S +    H  RS +  G  R
Sbjct: 14  EKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEG-RR 72

Query: 524 QETFDSETQESRDSAY--VEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRH-----RE 576
            E+ D  +++ +   +   E   D   + ++   +  D + R E   S    H     RE
Sbjct: 73  HESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRE 132

Query: 577 SRHRSRDVDREQDHNEC-------NKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNR 626
            RHRSR  +R++  +         ++ R R KS+ R  E+   + S+ R+ +   +R
Sbjct: 133 RRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHR 189



 Score = 36.2 bits (82), Expect = 0.094
 Identities = 42/170 (24%), Positives = 64/170 (37%), Gaps = 18/170 (10%)

Query: 465 SNSQGSQGDQRTDRSA-PIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSR 523
           S S+  +  +++D      RS S+++E    E   KS  +  S   H++    + +G  R
Sbjct: 43  SRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESKDKSSKKHKSEE-HNDKEHSSDKG--R 99

Query: 524 QETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRE------- 576
           +    SE  E R     E K      H    +  R H  R      S  R RE       
Sbjct: 100 ERLNSSENGEDRHKRK-ERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSR 158

Query: 577 ------SRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNE 620
                 SR RSR+  R       ++ R RH+++ R   +      KKR E
Sbjct: 159 SRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIE 208


>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
           containing B [Homo sapiens]
          Length = 546

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 42/167 (25%), Positives = 61/167 (36%), Gaps = 20/167 (11%)

Query: 469 GSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFD 528
           G +G +  DR    R +       S+ P  +   R S S  HH    G+S    R+   +
Sbjct: 244 GKEGAEEIDRHVERRRSRSPRR--SLSP--RRSPRRSRSRSHHREGHGSS-SFDRELERE 298

Query: 529 SETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQ 588
            E Q     A    KE      +D     R    R+     S  R R+   R RD +RE+
Sbjct: 299 KERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREK 358

Query: 589 DH---------------NECNKQRSRHKSKDRYCEKDGEVISKKRNE 620
           ++               NE  K+R R + + +     GEV  KK  E
Sbjct: 359 ENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKE 405



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 49/184 (26%), Positives = 69/184 (37%), Gaps = 38/184 (20%)

Query: 474 QRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGT---------------- 517
           QR +R A  R   + E   S    +  + R S S   H  RS +                
Sbjct: 302 QRLEREAKER---EKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREK 358

Query: 518 --SRGLSRQETFD----SETQESRDSAYVEPKEDYSHDHVD---HYASHRDHNHRDETHG 568
              RG  R   +D    +E ++ R+ +    KE  S   V+   H     D  HRD+   
Sbjct: 359 ENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRD 418

Query: 569 S------SDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAG 622
           S      S  R RE +HRSR   R    N   + RSR K K    + + +  S KR+ +G
Sbjct: 419 SKKEKKHSRSRSRERKHRSRSRSR----NAGKRSRSRSKEKSSKHKNESKEKSNKRSRSG 474

Query: 623 EWNR 626
              R
Sbjct: 475 SQGR 478



 Score = 35.0 bits (79), Expect = 0.21
 Identities = 36/174 (20%), Positives = 65/174 (37%), Gaps = 18/174 (10%)

Query: 466 NSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQE 525
           N +  + ++  +RS   RS  + EE+   E     +HR          +   SR   R+ 
Sbjct: 376 NEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKH 435

Query: 526 TFDSETQESRDSAYVEPKEDYS-HDHVDHYASHR-----DHNHRDETHGSSDHRHRES-- 577
              S ++ +   +    KE  S H +     S++          D    S    H  S  
Sbjct: 436 RSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKE 495

Query: 578 ----RHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRD 627
               R RS++   ++DH++   Q  +H   DR   +  + I ++  E    N+D
Sbjct: 496 KSRKRSRSKERSHKRDHSDSKDQSDKH---DR---RRSQSIEQESQEKQHKNKD 543



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 34/157 (21%), Positives = 61/157 (38%), Gaps = 8/157 (5%)

Query: 465 SNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQ 524
           S S+  +GD+R DR       ++       +  K+  +           RS   R  SR 
Sbjct: 340 SRSRDRKGDRR-DRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQR--SRG 396

Query: 525 ETFDSETQESRDSA-YVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRD 583
           E  + + +E +D   + + K D   +     +  R+  HR      S  R+   R RSR 
Sbjct: 397 EVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSR----SRSRNAGKRSRSRS 452

Query: 584 VDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNE 620
            ++   H   +K++S  +S+     +   V   K+ E
Sbjct: 453 KEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKRE 489



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 38/171 (22%), Positives = 62/171 (36%), Gaps = 11/171 (6%)

Query: 450 RTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAP 509
           R+L+    P      S+ +   G    DR        Q  E  + E  ++ + R S S  
Sbjct: 265 RSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKE--REKERRRSRSID 322

Query: 510 HHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGS 569
                 G  R  SR          SRD        D   +  +     RD ++ D+  G+
Sbjct: 323 R-----GLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDY-DKERGN 376

Query: 570 SDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNE 620
              + RE   RSR+  +EQ      +++   + KD    +D +  SKK  +
Sbjct: 377 EREKERE---RSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKK 424


>gi|14149807 coiled-coil domain containing 55 isoform 1 [Homo
           sapiens]
          Length = 558

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 34/134 (25%), Positives = 61/134 (45%), Gaps = 16/134 (11%)

Query: 499 KSQHRSSS-------SAPHHNHRSGTSRGLSRQETFDSETQESRDSA-------YVEPKE 544
           +SQ+ S S       S  HH   S TSRG  ++E    + ++SRD         Y + ++
Sbjct: 284 RSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKRED-QHQQKQSRDQENHYTDRDYRKERD 342

Query: 545 DYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKD 604
            + H    H  SH   + +++   + D R R  R   R+ DRE+ +++  ++R R ++  
Sbjct: 343 SHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREK-YSQREQERDRQQNDQ 401

Query: 605 RYCEKDGEVISKKR 618
               + GE   K +
Sbjct: 402 NRPSEKGEKEEKSK 415



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 10/116 (8%)

Query: 502 HRSSSSAPHHNHRSGTSRGLS-RQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDH 560
           HRS +    H+      RG S R  T  S T    +    + ++  S D  +HY   RD+
Sbjct: 283 HRSQN----HSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTD-RDY 337

Query: 561 NHRDETHGSSDHRHRES---RHRSRDVDREQDHNE-CNKQRSRHKSKDRYCEKDGE 612
               ++H   +  HR+S   RH   D  R +D  E  ++   R K +++Y +++ E
Sbjct: 338 RKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQE 393



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 71/348 (20%), Positives = 131/348 (37%), Gaps = 37/348 (10%)

Query: 299 LAKRSVLNNPS----KHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPA 354
           L K SV  N S    + ++ E     ++  +   + +   + A      V + D+I    
Sbjct: 23  LQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEM 82

Query: 355 QLSKTSLAPIIVYVKISSPKVLQRLIKS---RGKSQAKHLNVQMVAADKLAQCP------ 405
           Q  K    P ++  K   PK +  L+K+   R K Q K +  ++    ++ +        
Sbjct: 83  QKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEA 142

Query: 406 --PELFDVILDENQLEDACEHLADYLEAYWKATHPPS-SSLPNPLLSRTLATSSLPLSPT 462
                +   L E   E+  E  A  LEA    T     S     LL++ +    +P    
Sbjct: 143 FVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSF 202

Query: 463 LASNSQGSQGDQRTDRSAPIRSASQAEEEPSV---------EPVKKSQHRSSSSAPHHNH 513
             + S G + ++    S  + S ++  +E  +          P   S   + SSA     
Sbjct: 203 REARS-GIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIE 261

Query: 514 RSGTS-RGLSRQETFDSETQESRDSAYVE-PKEDYSHD---HVDHYASHRDHNHRDETHG 568
            +  + R     ET +++ +  R   +   P E+  H    H     + R H  R++ H 
Sbjct: 262 ETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQ 321

Query: 569 SSDHRHRESRHRSRDVDREQD---HNECNKQRS---RHKSKDRYCEKD 610
               R +E+ +  RD  +E+D   H E + + S   RH+ +D+   +D
Sbjct: 322 QKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARD 369



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 33/147 (22%), Positives = 53/147 (36%), Gaps = 10/147 (6%)

Query: 473 DQRTDRSAPIRSASQAEEEPSVEPVKKSQH-RSSSSAPHHNHRSGTSRGLSRQETFDSET 531
           D    R A  R +     E   +P  + Q  RS         R   S+    ++   ++ 
Sbjct: 342 DSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQ 401

Query: 532 QESRDSAYVEPKEDYSHDHV-------DHYASHRDHNHRDETHGSSDHRH--RESRHRSR 582
               +    E K     +H+       ++   +RD   R+    SS+     +ES   SR
Sbjct: 402 NRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSR 461

Query: 583 DVDREQDHNECNKQRSRHKSKDRYCEK 609
             D+  D    NK R+  K K+R  EK
Sbjct: 462 AKDKFLDQERSNKMRNMAKDKERNQEK 488


>gi|23111062 splicing factor, arginine/serine-rich 8 [Homo sapiens]
          Length = 951

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 62/257 (24%), Positives = 103/257 (40%), Gaps = 30/257 (11%)

Query: 360 SLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLE 419
           ++AP  V V+   P++ Q  ++++   Q     +   A +KLAQ   E  +  L   +  
Sbjct: 626 AVAPPCVVVEEKKPQLTQEELEAKQAKQKLEDRLAAAAREKLAQASKESKEKQLQAERKR 685

Query: 420 DACEHLADYLEAYWKA----------THPPSSSLPNPLLSRTLATSSLPLSPTLASNSQG 469
            A   L        +A          +   SS+ P PLL     T   PL PTL    + 
Sbjct: 686 KAALFLQTLKNPLPEAEAGKIEESPFSVEESSTTPCPLL-----TGGRPL-PTL----EV 735

Query: 470 SQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDS 529
              D+ + +S   +   + EE+   +   K + R+ S +P + H S  SR  S      S
Sbjct: 736 KPPDRPSSKS---KDPPREEEKEKKKKKHKKRSRTRSRSPKY-HSSSKSRSRSH-----S 786

Query: 530 ETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQD 589
           + + S  SAY   +   S        +H     R+E    + +R   S   SR   R + 
Sbjct: 787 KAKHSLPSAYRTVRRSRSRSRSPRRRAHSPERRREERSVPTAYRVSRSPGASRKRTRSRS 846

Query: 590 -HNECNKQRSRHKSKDR 605
            H +  K+RSR ++K +
Sbjct: 847 PHEKKKKRRSRSRTKSK 863


>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
          Length = 715

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 45/183 (24%), Positives = 76/183 (41%), Gaps = 17/183 (9%)

Query: 460 SPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNH---RSG 516
           SPT  S+   S     T       S S++         K++  R  S +   NH   RS 
Sbjct: 258 SPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSR 317

Query: 517 TSRGL----SRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNH-----RDETH 567
           T +G+     R     S ++    +    P+   SH+   + +  R H+H     ++  H
Sbjct: 318 TRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDH 377

Query: 568 -GSSDHRHRESRHRSRDVDREQDHNEC---NKQRSRHKSKDRYCEKDGEVISKKRNEAGE 623
            GSS  R    R +S   ++++DH+     NK R R +S+  Y  +D    S+  N+A +
Sbjct: 378 RGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARD-RSRSRSPNKARD 436

Query: 624 WNR 626
            +R
Sbjct: 437 CSR 439



 Score = 37.7 bits (86), Expect = 0.032
 Identities = 35/162 (21%), Positives = 68/162 (41%), Gaps = 16/162 (9%)

Query: 460 SPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPH--HNHRSGT 517
           SP  A +   S+   +    +  RS ++A +        K++ RS S +P+   +H    
Sbjct: 406 SPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSR 465

Query: 518 SRGLSRQETFDSETQESRDSAYV-EPKEDYSHDHV----------DHYASHRDHNHRDET 566
           S   +R  +      + RD + +  P ++  H                +S ++ +HR   
Sbjct: 466 SPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSR 525

Query: 567 HGSSDHRHRESRHRSRDVDREQDHN---ECNKQRSRHKSKDR 605
             S + + R+SR  +++ DR Q  +   E   ++SR  SK+R
Sbjct: 526 SPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKER 567



 Score = 36.2 bits (82), Expect = 0.094
 Identities = 37/157 (23%), Positives = 65/157 (41%), Gaps = 12/157 (7%)

Query: 460 SPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAP-----HHNHR 514
           SP  A +   S+   +    +  RS ++A +        K +  S   +P     H   R
Sbjct: 442 SPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSR 501

Query: 515 SGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHR- 573
           S +     RQ    S+ ++ R S    P ++            RD   R ++   S+ R 
Sbjct: 502 SPSKERQCRQSRSSSKERDHRRSR--SPSKERQRRQSRSPNKERD---RSQSRSPSEERE 556

Query: 574 HRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKD 610
           HR+SR  S++ DR +  +  +K+R R +S+    E+D
Sbjct: 557 HRQSRSPSKERDRRRWRSP-SKERERRQSRSSSEERD 592



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 45/180 (25%), Positives = 61/180 (33%), Gaps = 15/180 (8%)

Query: 433 WKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEP 492
           +KA     S  PN     + + S         S S   + D     S       +    P
Sbjct: 444 YKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSP 503

Query: 493 SVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVD 552
           S E   +    SS    H   RS +     RQ    S  +E   S    P E+      +
Sbjct: 504 SKERQCRQSRSSSKERDHRRSRSPSKERQRRQSR--SPNKERDRSQSRSPSEER-----E 556

Query: 553 HYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNEC---NKQ----RSRHKSKDR 605
           H  S      RD     S  + RE R +SR    E+DH+     NKQ    R R  SK++
Sbjct: 557 HRQSRSPSKERDRRRWRSPSKERE-RRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEK 615



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 42/174 (24%), Positives = 66/174 (37%), Gaps = 32/174 (18%)

Query: 433 WKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQG-SQGDQRTDRSAPIRSASQAEEE 491
           WK  H  + S      +R    S +       S+S+G SQ   RT R     + S+    
Sbjct: 307 WKRNHSRARSR-----TRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSR---N 358

Query: 492 PSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHV 551
           PS E   +S   S SS+   +HR  +S             +ES  S    P +   H   
Sbjct: 359 PSKE---RSHSHSRSSSKERDHRGSSS-----------PRKESGRSQSGSPNKQRDHSRS 404

Query: 552 DHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDR 605
                 RD +     + + D     S +++RD         C++ RS +K++DR
Sbjct: 405 RSPNKARDRSRSRSPYKARDRSRSRSPNKARD---------CSRSRSPYKARDR 449


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 32/164 (19%), Positives = 60/164 (36%), Gaps = 8/164 (4%)

Query: 464 ASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSR 523
           A   +  Q D+   R        + E E + +  ++ + +        +  S   R   R
Sbjct: 155 AEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERER 214

Query: 524 QETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRD 583
           +   ++ET+  R +       D   D        R+     E     +    + R R RD
Sbjct: 215 ERETETETERKRQT-------DRERDRQRKTEREREKQAERERASERETERDKERERERD 267

Query: 584 VDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRD 627
            DR++D  +  ++R   + + R  E+D E   +KR    E  R+
Sbjct: 268 RDRDRDRRQKERERQTDRKRQRRTERDRET-ERKRERQRERERE 310



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 33/150 (22%), Positives = 57/150 (38%), Gaps = 12/150 (8%)

Query: 473 DQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQ 532
           +++TDR    R+    E E      K+ + R        N +    R   R+     ET+
Sbjct: 280 ERQTDRKRQRRTERDRETER-----KRERQRERERERERNRKRERERERERERERQRETE 334

Query: 533 ESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNE 592
             R     E + +            R+     E    ++      R R R   RE++  E
Sbjct: 335 RDR-----EKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERE 389

Query: 593 CNKQRSRHKSKDRYCEK--DGEVISKKRNE 620
            ++ R R K ++R  EK  DG+  ++K+ E
Sbjct: 390 RDRDRDRQKERERQTEKDRDGQRETEKQRE 419



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 18/68 (26%), Positives = 36/68 (52%), Gaps = 1/68 (1%)

Query: 556 SHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHN-ECNKQRSRHKSKDRYCEKDGEVI 614
           + R+ + + E     D   +  RHR R  DRE++   + +++R R + K+R  +K+ E  
Sbjct: 71  TERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERE 130

Query: 615 SKKRNEAG 622
           +++  E G
Sbjct: 131 TEREGERG 138



 Score = 37.4 bits (85), Expect = 0.042
 Identities = 30/118 (25%), Positives = 47/118 (39%), Gaps = 13/118 (11%)

Query: 496 PVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYA 555
           P  +   R       H    G  R  +RQ+    E +  R+    E + D   +      
Sbjct: 31  PGSQESPRRRGLGQAHKDADGDDRERNRQK----ERERRREKRQTERETDRKRERRREKD 86

Query: 556 SHRDHN-HRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGE 612
            HR  + HR+        R R++  R RD  RE       K+R+R K ++R  E++GE
Sbjct: 87  RHRKRDRHRERQRDREKERERQT-DRERDRQRE-------KERNRQKERERETEREGE 136



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 26/144 (18%), Positives = 59/144 (40%), Gaps = 11/144 (7%)

Query: 468 QGSQG-DQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQET 526
           +G +G D++TD          AE+E   +  ++ Q ++       N +    R  +RQE 
Sbjct: 134 EGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTE-----RNRQKEREREKNRQER 188

Query: 527 FDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDR 586
            + E Q  +++   +   +   +      +  +   + +T    D + +  R R +  +R
Sbjct: 189 RERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAER 248

Query: 587 E-----QDHNECNKQRSRHKSKDR 605
           E     +   +  ++R R + +DR
Sbjct: 249 ERASERETERDKERERERDRDRDR 272



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 34/157 (21%), Positives = 58/157 (36%), Gaps = 14/157 (8%)

Query: 471 QGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSE 530
           Q ++ TDR    R              K+ +HR             T R   RQ   +  
Sbjct: 70  QTERETDRKRERRREKDRHR-------KRDRHRERQRDREKERERQTDRERDRQREKERN 122

Query: 531 TQESRDSAYVEPKE---DYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDRE 587
            Q+ R+       E   D   D        RD     E     + + +  R+R ++ +RE
Sbjct: 123 RQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERERE 182

Query: 588 ---QDHNECNKQRSR-HKSKDRYCEKDGEVISKKRNE 620
              Q+  E  +QR + +K++DR+ E+  E   ++  E
Sbjct: 183 KNRQERRERERQREKENKTEDRHSERGRERERERETE 219



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 36/169 (21%), Positives = 63/169 (37%), Gaps = 17/169 (10%)

Query: 468 QGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQ-----HRSSSSAPHHNHRSGTSRGLS 522
           Q  + ++  DR +      + E E   E  +K Q      R   +      ++   R   
Sbjct: 194 QREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASE 253

Query: 523 RQETFDSETQESRDSAYVEPKEDYSHDH-VDHYASHRDHNHRDETHGSSDHRHRE---SR 578
           R+   D E +  RD      +     +   D     R    R+        R RE    R
Sbjct: 254 RETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERER 313

Query: 579 HRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRD 627
           +R R+ +RE++     ++R R +  +R  EK+ E   +KR    E +R+
Sbjct: 314 NRKRERERERE-----RERERQRETERDREKERE---RKRKRQTEMDRE 354



 Score = 33.9 bits (76), Expect = 0.47
 Identities = 39/202 (19%), Positives = 69/202 (34%), Gaps = 12/202 (5%)

Query: 426 ADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSA 485
           AD L   W        ++P     R   +   P    L    + + GD R       R  
Sbjct: 10  ADQLGTLWVEV-----TIPLDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERER 64

Query: 486 SQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKED 545
            + + +   E  +K + R      H        R   R++  + +T   RD      KE 
Sbjct: 65  RREKRQTERETDRKRERRREKDR-HRKRDRHRERQRDREKERERQTDRERDRQ--REKER 121

Query: 546 YSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDRE-QDHNECNKQRSRHKSKD 604
                 +          RD     +D +    R R  + +RE Q   E  +Q  R++ K+
Sbjct: 122 NRQKERERETEREGERGRDR---QTDGQRERERQRDAEKERERQTDRERQRQTERNRQKE 178

Query: 605 RYCEKDGEVISKKRNEAGEWNR 626
           R  EK+ +   ++  +  + N+
Sbjct: 179 REREKNRQERRERERQREKENK 200


>gi|155030236 ribonuclease III, nuclear isoform 2 [Homo sapiens]
          Length = 1337

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 10/78 (12%)

Query: 542 PKEDYSHDHVDHYASHRDHNHRDETHGSSD-HRHRESRHRSRDVDREQDHN------ECN 594
           P E  S + + HY    DH HRD +HG  + HR  + R R R  DR +  +      +  
Sbjct: 216 PSERRSPERLKHYD---DHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYDRG 272

Query: 595 KQRSRHKSKDRYCEKDGE 612
           +  SRH+S +R  E++ E
Sbjct: 273 RTPSRHRSYERSRERERE 290


>gi|155030234 ribonuclease III, nuclear isoform 1 [Homo sapiens]
          Length = 1374

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 10/78 (12%)

Query: 542 PKEDYSHDHVDHYASHRDHNHRDETHGSSD-HRHRESRHRSRDVDREQDHN------ECN 594
           P E  S + + HY    DH HRD +HG  + HR  + R R R  DR +  +      +  
Sbjct: 216 PSERRSPERLKHYD---DHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYDRG 272

Query: 595 KQRSRHKSKDRYCEKDGE 612
           +  SRH+S +R  E++ E
Sbjct: 273 RTPSRHRSYERSRERERE 290


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.126    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,580,008
Number of Sequences: 37866
Number of extensions: 1170720
Number of successful extensions: 7241
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 108
Number of HSP's successfully gapped in prelim test: 264
Number of HSP's that attempted gapping in prelim test: 5384
Number of HSP's gapped (non-prelim): 1432
length of query: 632
length of database: 18,247,518
effective HSP length: 108
effective length of query: 524
effective length of database: 14,157,990
effective search space: 7418786760
effective search space used: 7418786760
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.