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Search of human proteins with 14589937
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14589937 protocadherin 8 isoform 2 precursor [Homo sapiens]
(973 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14589937 protocadherin 8 isoform 2 precursor [Homo sapiens] 1937 0.0
gi|6631102 protocadherin 8 isoform 1 precursor [Homo sapiens] 1803 0.0
gi|14589929 protocadherin 18 precursor [Homo sapiens] 549 e-156
gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens] 506 e-143
gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens] 506 e-143
gi|94538350 protocadherin 17 precursor [Homo sapiens] 469 e-132
gi|157426847 protocadherin 19 isoform a [Homo sapiens] 468 e-131
gi|157426845 protocadherin 19 isoform b [Homo sapiens] 468 e-131
gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precurso... 448 e-125
gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precurs... 448 e-125
gi|7706113 protocadherin 12 precursor [Homo sapiens] 445 e-124
gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precurs... 439 e-123
gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precurs... 439 e-123
gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo sap... 434 e-121
gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo sapi... 434 e-121
gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo sapi... 432 e-120
gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens] 432 e-120
gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo sapi... 426 e-119
gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens] 426 e-119
gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens] 426 e-119
gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo sapi... 426 e-119
gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precurs... 423 e-118
gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precur... 423 e-118
gi|14165400 protocadherin alpha 1 isoform 2 precursor [Homo sapi... 422 e-118
gi|9256582 protocadherin alpha 1 isoform 1 precursor [Homo sapiens] 422 e-118
gi|14165381 protocadherin alpha 10 isoform 2 precursor [Homo sap... 421 e-117
gi|9256574 protocadherin alpha 10 isoform 1 precursor [Homo sapi... 421 e-117
gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo sapi... 420 e-117
gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens] 420 e-117
gi|14196468 protocadherin gamma subfamily A, 4 isoform 2 precurs... 420 e-117
>gi|14589937 protocadherin 8 isoform 2 precursor [Homo sapiens]
Length = 973
Score = 1937 bits (5017), Expect = 0.0
Identities = 973/973 (100%), Positives = 973/973 (100%)
Query: 1 MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD 60
MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD
Sbjct: 1 MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD 60
Query: 61 TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH 120
TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH
Sbjct: 61 TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH 120
Query: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180
VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP
Sbjct: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180
Query: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240
FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND
Sbjct: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240
Query: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD 300
HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD
Sbjct: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD 300
Query: 301 PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA 360
PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA
Sbjct: 301 PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA 360
Query: 361 APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD 420
APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD
Sbjct: 361 APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD 420
Query: 421 SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480
SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV
Sbjct: 421 SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480
Query: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540
RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE
Sbjct: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540
Query: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600
VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL
Sbjct: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600
Query: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660
DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE
Sbjct: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660
Query: 661 AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720
AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA
Sbjct: 661 AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720
Query: 721 PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE
Sbjct: 721 PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
Query: 781 PYGASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALK 840
PYGASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALK
Sbjct: 781 PYGASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALK 840
Query: 841 KDLINHMQSGLWACTAECKILGHSDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDP 900
KDLINHMQSGLWACTAECKILGHSDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDP
Sbjct: 841 KDLINHMQSGLWACTAECKILGHSDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDP 900
Query: 901 LRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPG 960
LRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPG
Sbjct: 901 LRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPG 960
Query: 961 RYLSPKKGANENV 973
RYLSPKKGANENV
Sbjct: 961 RYLSPKKGANENV 973
>gi|6631102 protocadherin 8 isoform 1 precursor [Homo sapiens]
Length = 1070
Score = 1803 bits (4671), Expect = 0.0
Identities = 944/1070 (88%), Positives = 949/1070 (88%), Gaps = 97/1070 (9%)
Query: 1 MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD 60
MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD
Sbjct: 1 MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD 60
Query: 61 TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH 120
TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH
Sbjct: 61 TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH 120
Query: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180
VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP
Sbjct: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180
Query: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240
FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND
Sbjct: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240
Query: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD 300
HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD
Sbjct: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD 300
Query: 301 PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA 360
PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA
Sbjct: 301 PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA 360
Query: 361 APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD 420
APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD
Sbjct: 361 APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD 420
Query: 421 SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480
SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV
Sbjct: 421 SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480
Query: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540
RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE
Sbjct: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540
Query: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600
VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL
Sbjct: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600
Query: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660
DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE
Sbjct: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660
Query: 661 AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720
AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA
Sbjct: 661 AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720
Query: 721 PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE
Sbjct: 721 PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
Query: 781 PY---------------GAS------------------------PGFGKEP-------AP 794
GAS PG GK P AP
Sbjct: 781 VRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAP 840
Query: 795 PVAV----WKGHSFNTISGREAEKFSGKD------------------------------- 819
P AV G + +G A F G+
Sbjct: 841 PPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHS 900
Query: 820 ----SGKGDSDFNDSDS------------DISGDALKKDLINHMQSGLWACTAECKILGH 863
SG+ F+ DS DISGDALKKDLINHMQSGLWACTAECKILGH
Sbjct: 901 FNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGH 960
Query: 864 SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK 923
SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK
Sbjct: 961 SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK 1020
Query: 924 VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV 973
VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV
Sbjct: 1021 VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV 1070
>gi|14589929 protocadherin 18 precursor [Homo sapiens]
Length = 1135
Score = 549 bits (1415), Expect = e-156
Identities = 307/757 (40%), Positives = 447/757 (59%), Gaps = 60/757 (7%)
Query: 30 KTVRYSTFEEDAPGTVIGTLAED-----LHMKVSGDTSFRLMKQFNSSLLRVREGDGQLT 84
K ++Y +EE G+VI L+ED L + FR M++ NS LL V E +G+++
Sbjct: 28 KNLKYRIYEEQRVGSVIARLSEDVADVLLKLPNPSTVRFRAMQRGNSPLLVVNEDNGEIS 87
Query: 85 VGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEV 144
+G A +DRE+LC + C + FDV++ E +L H+EVEV D+ND++P+F R+ IP+E+
Sbjct: 88 IG-ATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEI 146
Query: 145 SEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELD 204
SE AAVGTRIPL+ D DVG N L T L+ + F +E++TR DGA+ A+L++++ELD
Sbjct: 147 SESAAVGTRIPLDSAFDPDVGENSLHTYSLSA-NDFFNIEVRTRTDGAKYAELIVVRELD 205
Query: 205 RESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSL 264
RE +++Y L+L A D G P RS ++ L + + D+ND+SPAF Q + ++L E++PVG+L
Sbjct: 206 RELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYI-IQLLENSPVGTL 264
Query: 265 LLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDV 324
LLDL+A DPDEG NG +V++F + P+ F++D G LTL VDYE +YE+DV
Sbjct: 265 LLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDV 324
Query: 325 RAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADA 384
+AQD GP A CK+I+++ DVNDN P+I I L +PG
Sbjct: 325 QAQDLGPNSIPAHCKIIIKVVDVNDNKPEININ-LMSPGKE------------------- 364
Query: 385 SSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYA 444
S + EG ++ VALV D+DSG NG++ C L+GH HF+LQ Y
Sbjct: 365 ------------EISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYE 412
Query: 445 GSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEV 504
+YL++T A+LDRE+ +EY+LT++AEDRG P L TV+ +TV++ D NDN P F R YE
Sbjct: 413 NNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEF 472
Query: 505 SVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYAL 564
+ ENN PGAY+ TV A D DLG NGQVTY +LE+ + G +++TYV++DP+ GAIYAL
Sbjct: 473 VISENNSPGAYITTVTATDPDLGENGQVTYTILESFI--LGSSITTYVTIDPSNGAIYAL 530
Query: 565 RSFDYETLRQLDVRIQASDGGSP-QLSSSALVQVRVLDQNDHAPVLVHPAPANGSLEVAV 623
R FD+E + Q+ ++A DGGSP QL S+ V + ++D+ND+ PV++ PA N + E+ +
Sbjct: 531 RIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITI 590
Query: 624 PGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPG 683
P V R++A D D G N EL+ + F I R+ +I T P
Sbjct: 591 PKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDI-HTNVSMDSVPY 649
Query: 684 RVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSV 743
+ ++I D G P L T + ++ E + S S S
Sbjct: 650 TEWELSVIIQDKGNPQLHTKVLLKCMIF----------------EYAESVTSTAMTSVSQ 693
Query: 744 LQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
D +I+II L C +LL ++ AT CNR KK+
Sbjct: 694 ASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKD 730
Score = 63.9 bits (154), Expect = 7e-10
Identities = 36/102 (35%), Positives = 50/102 (49%), Gaps = 17/102 (16%)
Query: 810 REAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWA-----------CTAEC 858
++ +KFS KDSG+GDS+ DSD D+ D+ L+ S L+ CT EC
Sbjct: 863 QDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEEC 922
Query: 859 KILGHSDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDP 900
++LGHSD+CW P PSP + + F P P
Sbjct: 923 RVLGHSDQCWMPPL------PSPSSDYRSNMFIPGEEFPTQP 958
>gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]
Length = 1040
Score = 506 bits (1304), Expect = e-143
Identities = 315/792 (39%), Positives = 444/792 (56%), Gaps = 77/792 (9%)
Query: 15 LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVS--GDTSFRLMKQFNSS 72
L LF+L W++ S+ + Y+ EE GT +G +AEDL + ++ F+ + +
Sbjct: 4 LLLFALLWMVEGVFSQ-LHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRTP 62
Query: 73 LLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHA 132
L + G L V + +DRE++C Q+P CVL +V F + L VE+EV D+ND+
Sbjct: 63 YLDLNLETGVLYVNEK-IDREQICKQSPSCVLHLEV--FLENPLELFQVEIEVLDINDNP 119
Query: 133 PRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGA 192
P FP + VE+SE A GTR PLE D DVG N L+ + P+S F +++QT+ DG
Sbjct: 120 PSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT-PNSYFSLDVQTQGDGN 178
Query: 193 QCADLVLLQELDRESQAAYSLELVAQDGGR----------------PP---RSATAALSV 233
+ A+LVL + LDRE QA + L A DGG PP R+ TA L++
Sbjct: 179 RFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTI 238
Query: 234 RVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEA 293
RVLD+ND+ PAF Q V V L E++P G+L++ L+A DPDEG NG+VV++F + P A
Sbjct: 239 RVLDSNDNVPAFDQ-PVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRA 297
Query: 294 RRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPD 353
R LF L PR+GRL ++G +DYE Y++ V+A+D GP A CKV+VR+ D NDNAP+
Sbjct: 298 RELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPE 357
Query: 354 IAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVAL 413
I+ + + V EGAA ++VAL
Sbjct: 358 ISFSTVK--------------------------------------EAVSEGAAPGTVVAL 379
Query: 414 VSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRG 473
S +DRDS NGQV+C L G FRL+ ++ Y +VT A LDRE Y LT+VA DRG
Sbjct: 380 FSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRG 439
Query: 474 APPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVT 533
P L T + V+V D NDNAP F++PVY+V V ENN PGAY+ V+A DRD G N Q+
Sbjct: 440 EPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLA 499
Query: 534 YRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQ-LSSS 592
Y +LE ++ G +V TYVS++ G +YALRSFDYE L+ +++A D GSPQ L+ +
Sbjct: 500 YSILECQI--QGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGN 557
Query: 593 ALVQVRVLDQNDHAPVLVHPAPA-NGSLEVAVPGRTAK-DTVVARVQARDADEGANGELA 650
A V + ++DQND+AP +V P P NG+ V R+A+ ++ RV A DAD+G N L
Sbjct: 558 ATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLT 617
Query: 651 FELQQQEPREAFAIGRRTGEILLTGDL-SQEPPGRVFRALLVISDGGRPPLTTTAT--VS 707
+ + + F + RTGE+ + ++ P R + ++ + D G+PPL++TAT V
Sbjct: 618 YSIVRGNEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQ 677
Query: 708 FVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAI 767
V A +G GS E RP SR G G D LI+II L + L A+
Sbjct: 678 LVDGAVEPQGGGGSGGGGSGEHQRP--SRSG--GGETSLDLTLILIIALGSVSFIFLLAM 733
Query: 768 IAIATTCNRRKK 779
I +A C + KK
Sbjct: 734 IVLAVRCQKEKK 745
Score = 60.5 bits (145), Expect = 8e-09
Identities = 33/69 (47%), Positives = 41/69 (59%), Gaps = 9/69 (13%)
Query: 805 NTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKK--DLINHMQSGLWACTAECKILG 862
N+ + +EA+ S KDSG GDS+ DSD D + A DL ++ CT ECK LG
Sbjct: 896 NSSAFQEADIVSSKDSGHGDSEQGDSDHDATNRAQSAGMDLFSN-------CTEECKALG 948
Query: 863 HSDRCWSPS 871
HSDRCW PS
Sbjct: 949 HSDRCWMPS 957
>gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]
Length = 896
Score = 506 bits (1304), Expect = e-143
Identities = 315/792 (39%), Positives = 444/792 (56%), Gaps = 77/792 (9%)
Query: 15 LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVS--GDTSFRLMKQFNSS 72
L LF+L W++ S+ + Y+ EE GT +G +AEDL + ++ F+ + +
Sbjct: 4 LLLFALLWMVEGVFSQ-LHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRTP 62
Query: 73 LLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHA 132
L + G L V + +DRE++C Q+P CVL +V F + L VE+EV D+ND+
Sbjct: 63 YLDLNLETGVLYVNEK-IDREQICKQSPSCVLHLEV--FLENPLELFQVEIEVLDINDNP 119
Query: 133 PRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGA 192
P FP + VE+SE A GTR PLE D DVG N L+ + P+S F +++QT+ DG
Sbjct: 120 PSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT-PNSYFSLDVQTQGDGN 178
Query: 193 QCADLVLLQELDRESQAAYSLELVAQDGGR----------------PP---RSATAALSV 233
+ A+LVL + LDRE QA + L A DGG PP R+ TA L++
Sbjct: 179 RFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTI 238
Query: 234 RVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEA 293
RVLD+ND+ PAF Q V V L E++P G+L++ L+A DPDEG NG+VV++F + P A
Sbjct: 239 RVLDSNDNVPAFDQ-PVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRA 297
Query: 294 RRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPD 353
R LF L PR+GRL ++G +DYE Y++ V+A+D GP A CKV+VR+ D NDNAP+
Sbjct: 298 RELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPE 357
Query: 354 IAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVAL 413
I+ + + V EGAA ++VAL
Sbjct: 358 ISFSTVK--------------------------------------EAVSEGAAPGTVVAL 379
Query: 414 VSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRG 473
S +DRDS NGQV+C L G FRL+ ++ Y +VT A LDRE Y LT+VA DRG
Sbjct: 380 FSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRG 439
Query: 474 APPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVT 533
P L T + V+V D NDNAP F++PVY+V V ENN PGAY+ V+A DRD G N Q+
Sbjct: 440 EPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLA 499
Query: 534 YRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQ-LSSS 592
Y +LE ++ G +V TYVS++ G +YALRSFDYE L+ +++A D GSPQ L+ +
Sbjct: 500 YSILECQI--QGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGN 557
Query: 593 ALVQVRVLDQNDHAPVLVHPAPA-NGSLEVAVPGRTAK-DTVVARVQARDADEGANGELA 650
A V + ++DQND+AP +V P P NG+ V R+A+ ++ RV A DAD+G N L
Sbjct: 558 ATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLT 617
Query: 651 FELQQQEPREAFAIGRRTGEILLTGDL-SQEPPGRVFRALLVISDGGRPPLTTTAT--VS 707
+ + + F + RTGE+ + ++ P R + ++ + D G+PPL++TAT V
Sbjct: 618 YSIVRGNEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQ 677
Query: 708 FVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAI 767
V A +G GS E RP SR G G D LI+II L + L A+
Sbjct: 678 LVDGAVEPQGGGGSGGGGSGEHQRP--SRSG--GGETSLDLTLILIIALGSVSFIFLLAM 733
Query: 768 IAIATTCNRRKK 779
I +A C + KK
Sbjct: 734 IVLAVRCQKEKK 745
>gi|94538350 protocadherin 17 precursor [Homo sapiens]
Length = 1159
Score = 469 bits (1206), Expect = e-132
Identities = 290/780 (37%), Positives = 426/780 (54%), Gaps = 91/780 (11%)
Query: 30 KTVRYSTFEEDAPGTVIGTLAEDLHMKV------------SGDTSFRLMKQFNSSLLRVR 77
K + YS EE GTVIG + D ++ S S+R+++ LL V
Sbjct: 19 KNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAPHLLDV- 77
Query: 78 EGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPR 137
+ D L +DRE LC +C L+ +V + +E + ++VE++D+ND+AP F
Sbjct: 78 DADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKE---ICMIKVEIQDINDNAPSFSS 134
Query: 138 AQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLA-EPHSPFRVELQTRADGAQCAD 196
QI +++SE AA GTR PL D D G NGL+T L + H F +++++R DG + +
Sbjct: 135 DQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPE 194
Query: 197 LVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELA 256
LV+ + LDRE Q ++L L A DGG PPRSAT ++V+V+D+ND+SP F + VEL
Sbjct: 195 LVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYL-VELP 253
Query: 257 EDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYER 316
E+AP+G++++DL+A D DEGPNG+V+++F + P R LF +DP++G + + G +DYE
Sbjct: 254 ENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEE 313
Query: 317 QDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAA 376
E+DV+A+D GP P A CKV V++ D NDNAP I
Sbjct: 314 NGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSI---------------------- 351
Query: 377 AALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALY---- 432
G + GA S E A +++ALV +DRDSG NGQ++C +
Sbjct: 352 ------------GFVSVRQGALS---EAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGG 396
Query: 433 -----------GHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVR 481
G F+L+ Y Y VVT LDRE EYN+T+VA D G+PPL + +
Sbjct: 397 TGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTK 456
Query: 482 PYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEV 541
+ +++ DENDN P FT+ +Y + V ENN PG YL +V A+D DLG+NG V+Y +L + +
Sbjct: 457 SFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHI 516
Query: 542 GRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSP-QLSSSALVQVRVL 600
G ++ TYVSV+P GAIYALRSF++E + + ++ A D G+P L S+A V+V VL
Sbjct: 517 GDV--SIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVL 574
Query: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660
D ND+APV+V P N + E+ VP +V+ V+A D+D G +G L +E+
Sbjct: 575 DVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDH 634
Query: 661 AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720
F I +GEI T E V ++ ++D G+P T +A ++ + G P
Sbjct: 635 LFEIDPSSGEI-RTLHPFWEDVTPVVELVVKVTDHGKP--TLSAVAKLIIRSVSGSLP-- 689
Query: 721 PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
G P V+G WD L +I+ L+ +LLAA+I IA C R KE
Sbjct: 690 ---EGVPR----------VNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKE 736
Score = 52.0 bits (123), Expect = 3e-06
Identities = 31/83 (37%), Positives = 40/83 (48%), Gaps = 16/83 (19%)
Query: 810 REAEKFSGKDSGKGDSDFNDSDSDISG---------DALKKDLINHMQSGLWA------- 853
++ E+ S +DSG GDSD DSD D + +ALK + L
Sbjct: 880 KDPERASLRDSGHGDSDQADSDQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEPEECVN 939
Query: 854 CTAECKILGHSDRCWSPSCSGPN 876
CT EC++LGHSDRCW P N
Sbjct: 940 CTDECRVLGHSDRCWMPQFPAAN 962
>gi|157426847 protocadherin 19 isoform a [Homo sapiens]
Length = 1101
Score = 468 bits (1204), Expect = e-131
Identities = 287/771 (37%), Positives = 430/771 (55%), Gaps = 75/771 (9%)
Query: 15 LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLH-----MKVSGDTSFRLMKQF 69
L L ++ W + A ++YS EE GTVI +A+D + ++FR++
Sbjct: 9 LLLLAILWTQAAALIN-LKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67
Query: 70 NSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVN 129
L+ + G L V +DR+ LC Q+P+C+++ +V+S S E + ++VE++D+N
Sbjct: 68 APHLVDINPSSG-LLVTKQKIDRDLLCRQSPKCIISLEVMSSSME---ICVIKVEIKDLN 123
Query: 130 DHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRA 189
D+AP FP AQI +E+SE A+ GTRIPL+ D D G+ G+QT L P+ F +E++TR
Sbjct: 124 DNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELT-PNELFGLEIKTRG 182
Query: 190 DGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGA 249
DG++ A+LV+ + LDRE+Q+ YS + A DGG PPR T LS++V D+ND++P F +
Sbjct: 183 DGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSEST 242
Query: 250 VAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLA 309
A V + E++P + ++ L+A+DPDEG NG VV++F R LF++DP SG +T+
Sbjct: 243 YA-VSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVT 301
Query: 310 GPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSP 369
G +DYE YELDV+A+D GP A CKV V + D NDN P I +
Sbjct: 302 GALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINL------------- 348
Query: 370 FAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRC 429
+ + L S+P G ++ALV SDRDSG NG+V+C
Sbjct: 349 ---LSVNSELVEVSESAPPG-------------------YVIALVRVSDRDSGLNGRVQC 386
Query: 430 ALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGD 489
L G+ FRLQ Y ++ LDRE+ +YNLT+ A D G P L++ + +TV + D
Sbjct: 387 RLLGNVPFRLQ-EYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITD 445
Query: 490 ENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVS 549
ENDN P F++P Y+V V+ENN PGAYL +V+ARD DLG NG V+Y+++ ++V V
Sbjct: 446 ENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQV--RDMPVF 503
Query: 550 TYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVL 609
TYVS++P +G IYALRSF++E + + ++ A DGG P L S+A V+V +LD ND+ PV+
Sbjct: 504 TYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVI 563
Query: 610 VHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTG 669
P NG+ EV +P + +V V+A D DEG NG + +++ + + R F I + G
Sbjct: 564 TAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGD-RGFFEIDQVNG 622
Query: 670 EILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPER 729
E+ T + + ++V D G+ L+ +A V ++ PA A
Sbjct: 623 EVRTTRTFGESSKSS-YELIVVAHDHGKTSLSASALVLIYLS------PALDAQES---- 671
Query: 730 SRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
GSV + LI II L +L +I +A C R KE
Sbjct: 672 ----------MGSV---NLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKE 709
Score = 51.6 bits (122), Expect = 4e-06
Identities = 32/88 (36%), Positives = 42/88 (47%), Gaps = 16/88 (18%)
Query: 810 REAEKFSGKDSGKGDSDFNDSDSDISG----DALKKDLIN------------HMQSGLWA 853
++ E S KDSG +SD DS+ D+ D D++N H Q+ +
Sbjct: 850 KDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFH 909
Query: 854 CTAECKILGHSDRCWSPSCSGPNAHPSP 881
C EC+ILGHSDRCW P P SP
Sbjct: 910 CREECRILGHSDRCWMPRNPMPIRSKSP 937
>gi|157426845 protocadherin 19 isoform b [Homo sapiens]
Length = 1100
Score = 468 bits (1204), Expect = e-131
Identities = 287/771 (37%), Positives = 430/771 (55%), Gaps = 75/771 (9%)
Query: 15 LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLH-----MKVSGDTSFRLMKQF 69
L L ++ W + A ++YS EE GTVI +A+D + ++FR++
Sbjct: 9 LLLLAILWTQAAALIN-LKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67
Query: 70 NSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVN 129
L+ + G L V +DR+ LC Q+P+C+++ +V+S S E + ++VE++D+N
Sbjct: 68 APHLVDINPSSG-LLVTKQKIDRDLLCRQSPKCIISLEVMSSSME---ICVIKVEIKDLN 123
Query: 130 DHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRA 189
D+AP FP AQI +E+SE A+ GTRIPL+ D D G+ G+QT L P+ F +E++TR
Sbjct: 124 DNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELT-PNELFGLEIKTRG 182
Query: 190 DGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGA 249
DG++ A+LV+ + LDRE+Q+ YS + A DGG PPR T LS++V D+ND++P F +
Sbjct: 183 DGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSEST 242
Query: 250 VAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLA 309
A V + E++P + ++ L+A+DPDEG NG VV++F R LF++DP SG +T+
Sbjct: 243 YA-VSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVT 301
Query: 310 GPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSP 369
G +DYE YELDV+A+D GP A CKV V + D NDN P I +
Sbjct: 302 GALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINL------------- 348
Query: 370 FAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRC 429
+ + L S+P G ++ALV SDRDSG NG+V+C
Sbjct: 349 ---LSVNSELVEVSESAPPG-------------------YVIALVRVSDRDSGLNGRVQC 386
Query: 430 ALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGD 489
L G+ FRLQ Y ++ LDRE+ +YNLT+ A D G P L++ + +TV + D
Sbjct: 387 RLLGNVPFRLQ-EYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITD 445
Query: 490 ENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVS 549
ENDN P F++P Y+V V+ENN PGAYL +V+ARD DLG NG V+Y+++ ++V V
Sbjct: 446 ENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQV--RDMPVF 503
Query: 550 TYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVL 609
TYVS++P +G IYALRSF++E + + ++ A DGG P L S+A V+V +LD ND+ PV+
Sbjct: 504 TYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVI 563
Query: 610 VHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTG 669
P NG+ EV +P + +V V+A D DEG NG + +++ + + R F I + G
Sbjct: 564 TAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGD-RGFFEIDQVNG 622
Query: 670 EILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPER 729
E+ T + + ++V D G+ L+ +A V ++ PA A
Sbjct: 623 EVRTTRTFGESSKSS-YELIVVAHDHGKTSLSASALVLIYLS------PALDAQES---- 671
Query: 730 SRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
GSV + LI II L +L +I +A C R KE
Sbjct: 672 ----------MGSV---NLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKE 709
Score = 53.5 bits (127), Expect = 9e-07
Identities = 33/98 (33%), Positives = 46/98 (46%), Gaps = 16/98 (16%)
Query: 800 KGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISG----DALKKDLIN---------- 845
+ H + + ++ E S KDSG +SD DS+ D+ D D++N
Sbjct: 839 RAHLIKSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQM 898
Query: 846 --HMQSGLWACTAECKILGHSDRCWSPSCSGPNAHPSP 881
H Q+ + C EC+ILGHSDRCW P P SP
Sbjct: 899 PDHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSP 936
>gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precursor
[Homo sapiens]
Length = 1007
Score = 448 bits (1153), Expect = e-125
Identities = 271/704 (38%), Positives = 391/704 (55%), Gaps = 53/704 (7%)
Query: 12 LFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVS----GDTSFRLMK 67
L PL L L + A S+ +RYS EE APG ++G +A L +++ G +
Sbjct: 25 LLPLLLLLLLLLPGPAASQ-LRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRINHLG 83
Query: 68 QFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRD 127
+ L + G L V + +DRE LC Q P+C+L+ +V++ + + VEVE+ D
Sbjct: 84 APSPRYLELDLTSGALFVNER-IDREALCEQRPRCLLSLEVLAHNP--VAVSAVEVEILD 140
Query: 128 VNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQT 187
+ND++PRFPR ++VSE A G R +E D DVGAN +QT L+ P F ++L+
Sbjct: 141 INDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELS-PSEHFELDLKP 199
Query: 188 RADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247
+ ++ +LVL + LDRE A + L L A DGG P RS TA +SVRVLD ND+SPAF Q
Sbjct: 200 LQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQ 259
Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLT 307
V+L ED+P G+L++ L+A+DPDEG NG++ ++ + T R+LF +D +G +
Sbjct: 260 STY-RVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVR 318
Query: 308 LAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPAT 367
+ G +DYE +Y++ V+A DRGP P A CKV+V I DVNDNAP++ +T L +P
Sbjct: 319 VIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSP----- 373
Query: 368 SPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQV 427
VPE A ++VA++S +D+DSG N +V
Sbjct: 374 ---------------------------------VPENATPNTIVAVLSVNDQDSGPNRKV 400
Query: 428 RCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRV 487
L FRL + SY +V + LDRER+A YN+T+ A D G P L ++R V +
Sbjct: 401 SLGLEATLPFRLN-GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEI 459
Query: 488 GDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGA 547
D NDN P F Y + ++ENN PG L TV A D D N +VTY LLE E+ G
Sbjct: 460 SDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREI--QGLP 517
Query: 548 VSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAP 607
V++YVS++ A+G++YA+ SFDYE R+ V ++A D GSP LSS+ V V+D NDHAP
Sbjct: 518 VTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAP 577
Query: 608 VLVHPAPANGSLEVAVPGRTA-KDTVVARVQARDADEGANGELAFELQQQEPREAFAIGR 666
+++P N S + RTA +V +V A D+D G N L + L Q + F +
Sbjct: 578 HILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVEL 637
Query: 667 RTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVV 710
TGEI T + E G F +V+ D G P L+ + ++ V
Sbjct: 638 HTGEIRTTRKMGDE-SGSTFNLTVVVRDNGEPSLSASVAITVAV 680
Score = 138 bits (347), Expect = 3e-32
Identities = 157/603 (26%), Positives = 254/603 (42%), Gaps = 91/603 (15%)
Query: 137 RAQIPVEVSEGAAVGT---RIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQ 193
R +P E + GA VG + LE+ +G L+ L P SP +EL +
Sbjct: 45 RYSVPEEQAPGALVGNVARALGLEL---RRLGPGCLRINHLGAP-SPRYLELDLTSGA-- 98
Query: 194 CADLVLLQELDRES------QAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247
L + + +DRE+ + SLE++A + A +A+ V +LD ND+SP FP+
Sbjct: 99 ---LFVNERIDREALCEQRPRCLLSLEVLAHNP-----VAVSAVEVEILDINDNSPRFPR 150
Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRL----FRLDPRS 303
+++++E G+ A DPD G N + +P E L + + +
Sbjct: 151 PNY-QLQVSESVAPGARFHIESAQDPDVGANSVQTYEL---SPSEHFELDLKPLQENSKV 206
Query: 304 GRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPG 363
L L +D E+ + L + A D G R+ T ++ VR+ D NDN+P
Sbjct: 207 LELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSP----------- 255
Query: 364 APATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGA 423
F + L SP G +LV ++ SD D G+
Sbjct: 256 -----AFDQSTYRVQLR---EDSPPG-------------------TLVVKLNASDPDEGS 288
Query: 424 NGQVRCALYGHEHFRLQPAY---AGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480
NG++R +L + R + + A + V LD E + Y + + A DRG P+
Sbjct: 289 NGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGH 348
Query: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540
V + D NDNAP V EN P +A ++ D+D G N +V+ L
Sbjct: 349 CKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATL 408
Query: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600
R G ++Y V +G + D E + ++ + A+DGG PQL+S ++V +
Sbjct: 409 PFRLNGFGNSYTLV--VSGPL------DRERVAVYNITVTATDGGIPQLTSLRTLKVEIS 460
Query: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--- 657
D ND+ P + + + E +PG ++ VQA D DE N E+ + L ++E
Sbjct: 461 DINDNPPSFLEDSYSIYIQENNLPG-----VLLCTVQATDPDEKENAEVTYSLLEREIQG 515
Query: 658 -PREAF-AIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGG 715
P ++ +I +G + E R F + D G PPL++T T + V
Sbjct: 516 LPVTSYVSINSASGSLYAVNSFDYEK-FREFFVTVEAQDKGSPPLSSTVTANVYVVDMND 574
Query: 716 RGP 718
P
Sbjct: 575 HAP 577
Score = 111 bits (277), Expect = 4e-24
Identities = 102/371 (27%), Positives = 151/371 (40%), Gaps = 41/371 (11%)
Query: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180
V V++ DVND+AP + V E A T + + D+D G N ++ L E P
Sbjct: 351 VLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGL-EATLP 409
Query: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240
FR+ LV+ LDRE A Y++ + A DGG P ++ L V + D ND
Sbjct: 410 FRLN-----GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDIND 464
Query: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPP--EARRLFR 298
+ P+F + + + + + E+ G LL + A DPDE N +V ++ R
Sbjct: 465 NPPSFLEDSYS-IYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVS 523
Query: 299 LDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITP 358
++ SG L DYE+ + + V AQD+G P ++T V + D+ND+AP I
Sbjct: 524 INSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYP- 582
Query: 359 LAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSD 418
T + A +VP A LV V D
Sbjct: 583 -------------------------------TSTNSSAAFEMVPRTAPAGYLVTKVIAMD 611
Query: 419 RDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLR 478
DSG N + L L + + T + E + +NLT+V D G P L
Sbjct: 612 SDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLS 671
Query: 479 TVRPYTVRVGD 489
TV V D
Sbjct: 672 ASVAITVAVVD 682
Score = 46.2 bits (108), Expect = 1e-04
Identities = 43/161 (26%), Positives = 67/161 (41%), Gaps = 39/161 (24%)
Query: 106 FDVVSFSQEQFRLVHVEVEVRD------------------VNDHAPRFPRAQIPVEVSEG 147
+ V SF E+FR V VE +D +NDHAP P +
Sbjct: 532 YAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHI---LYPTSTNSS 588
Query: 148 AA---------VGTRIPLEVPVDEDVGANGLQTVRLAEPH--SPFRVELQTRADGAQCAD 196
AA G + + +D D G N LA+ F+VEL T +
Sbjct: 589 AAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHT-------GE 641
Query: 197 LVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLD 237
+ +++ ES + ++L +V +D G P SA+ A++V V+D
Sbjct: 642 IRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682
>gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precursor
[Homo sapiens]
Length = 884
Score = 448 bits (1153), Expect = e-125
Identities = 271/704 (38%), Positives = 391/704 (55%), Gaps = 53/704 (7%)
Query: 12 LFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVS----GDTSFRLMK 67
L PL L L + A S+ +RYS EE APG ++G +A L +++ G +
Sbjct: 25 LLPLLLLLLLLLPGPAASQ-LRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRINHLG 83
Query: 68 QFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRD 127
+ L + G L V + +DRE LC Q P+C+L+ +V++ + + VEVE+ D
Sbjct: 84 APSPRYLELDLTSGALFVNER-IDREALCEQRPRCLLSLEVLAHNP--VAVSAVEVEILD 140
Query: 128 VNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQT 187
+ND++PRFPR ++VSE A G R +E D DVGAN +QT L+ P F ++L+
Sbjct: 141 INDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELS-PSEHFELDLKP 199
Query: 188 RADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247
+ ++ +LVL + LDRE A + L L A DGG P RS TA +SVRVLD ND+SPAF Q
Sbjct: 200 LQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQ 259
Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLT 307
V+L ED+P G+L++ L+A+DPDEG NG++ ++ + T R+LF +D +G +
Sbjct: 260 STY-RVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVR 318
Query: 308 LAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPAT 367
+ G +DYE +Y++ V+A DRGP P A CKV+V I DVNDNAP++ +T L +P
Sbjct: 319 VIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSP----- 373
Query: 368 SPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQV 427
VPE A ++VA++S +D+DSG N +V
Sbjct: 374 ---------------------------------VPENATPNTIVAVLSVNDQDSGPNRKV 400
Query: 428 RCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRV 487
L FRL + SY +V + LDRER+A YN+T+ A D G P L ++R V +
Sbjct: 401 SLGLEATLPFRLN-GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEI 459
Query: 488 GDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGA 547
D NDN P F Y + ++ENN PG L TV A D D N +VTY LLE E+ G
Sbjct: 460 SDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREI--QGLP 517
Query: 548 VSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAP 607
V++YVS++ A+G++YA+ SFDYE R+ V ++A D GSP LSS+ V V+D NDHAP
Sbjct: 518 VTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAP 577
Query: 608 VLVHPAPANGSLEVAVPGRTA-KDTVVARVQARDADEGANGELAFELQQQEPREAFAIGR 666
+++P N S + RTA +V +V A D+D G N L + L Q + F +
Sbjct: 578 HILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVEL 637
Query: 667 RTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVV 710
TGEI T + E G F +V+ D G P L+ + ++ V
Sbjct: 638 HTGEIRTTRKMGDE-SGSTFNLTVVVRDNGEPSLSASVAITVAV 680
Score = 138 bits (347), Expect = 3e-32
Identities = 157/603 (26%), Positives = 254/603 (42%), Gaps = 91/603 (15%)
Query: 137 RAQIPVEVSEGAAVGT---RIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQ 193
R +P E + GA VG + LE+ +G L+ L P SP +EL +
Sbjct: 45 RYSVPEEQAPGALVGNVARALGLEL---RRLGPGCLRINHLGAP-SPRYLELDLTSGA-- 98
Query: 194 CADLVLLQELDRES------QAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247
L + + +DRE+ + SLE++A + A +A+ V +LD ND+SP FP+
Sbjct: 99 ---LFVNERIDREALCEQRPRCLLSLEVLAHNP-----VAVSAVEVEILDINDNSPRFPR 150
Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRL----FRLDPRS 303
+++++E G+ A DPD G N + +P E L + + +
Sbjct: 151 PNY-QLQVSESVAPGARFHIESAQDPDVGANSVQTYEL---SPSEHFELDLKPLQENSKV 206
Query: 304 GRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPG 363
L L +D E+ + L + A D G R+ T ++ VR+ D NDN+P
Sbjct: 207 LELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSP----------- 255
Query: 364 APATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGA 423
F + L SP G +LV ++ SD D G+
Sbjct: 256 -----AFDQSTYRVQLR---EDSPPG-------------------TLVVKLNASDPDEGS 288
Query: 424 NGQVRCALYGHEHFRLQPAY---AGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480
NG++R +L + R + + A + V LD E + Y + + A DRG P+
Sbjct: 289 NGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGH 348
Query: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540
V + D NDNAP V EN P +A ++ D+D G N +V+ L
Sbjct: 349 CKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATL 408
Query: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600
R G ++Y V +G + D E + ++ + A+DGG PQL+S ++V +
Sbjct: 409 PFRLNGFGNSYTLV--VSGPL------DRERVAVYNITVTATDGGIPQLTSLRTLKVEIS 460
Query: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--- 657
D ND+ P + + + E +PG ++ VQA D DE N E+ + L ++E
Sbjct: 461 DINDNPPSFLEDSYSIYIQENNLPG-----VLLCTVQATDPDEKENAEVTYSLLEREIQG 515
Query: 658 -PREAF-AIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGG 715
P ++ +I +G + E R F + D G PPL++T T + V
Sbjct: 516 LPVTSYVSINSASGSLYAVNSFDYEK-FREFFVTVEAQDKGSPPLSSTVTANVYVVDMND 574
Query: 716 RGP 718
P
Sbjct: 575 HAP 577
Score = 111 bits (277), Expect = 4e-24
Identities = 102/371 (27%), Positives = 151/371 (40%), Gaps = 41/371 (11%)
Query: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180
V V++ DVND+AP + V E A T + + D+D G N ++ L E P
Sbjct: 351 VLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGL-EATLP 409
Query: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240
FR+ LV+ LDRE A Y++ + A DGG P ++ L V + D ND
Sbjct: 410 FRLN-----GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDIND 464
Query: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPP--EARRLFR 298
+ P+F + + + + + E+ G LL + A DPDE N +V ++ R
Sbjct: 465 NPPSFLEDSYS-IYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVS 523
Query: 299 LDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITP 358
++ SG L DYE+ + + V AQD+G P ++T V + D+ND+AP I
Sbjct: 524 INSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYP- 582
Query: 359 LAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSD 418
T + A +VP A LV V D
Sbjct: 583 -------------------------------TSTNSSAAFEMVPRTAPAGYLVTKVIAMD 611
Query: 419 RDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLR 478
DSG N + L L + + T + E + +NLT+V D G P L
Sbjct: 612 SDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLS 671
Query: 479 TVRPYTVRVGD 489
TV V D
Sbjct: 672 ASVAITVAVVD 682
Score = 46.2 bits (108), Expect = 1e-04
Identities = 43/161 (26%), Positives = 67/161 (41%), Gaps = 39/161 (24%)
Query: 106 FDVVSFSQEQFRLVHVEVEVRD------------------VNDHAPRFPRAQIPVEVSEG 147
+ V SF E+FR V VE +D +NDHAP P +
Sbjct: 532 YAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHI---LYPTSTNSS 588
Query: 148 AA---------VGTRIPLEVPVDEDVGANGLQTVRLAEPH--SPFRVELQTRADGAQCAD 196
AA G + + +D D G N LA+ F+VEL T +
Sbjct: 589 AAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHT-------GE 641
Query: 197 LVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLD 237
+ +++ ES + ++L +V +D G P SA+ A++V V+D
Sbjct: 642 IRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682
>gi|7706113 protocadherin 12 precursor [Homo sapiens]
Length = 1184
Score = 445 bits (1144), Expect = e-124
Identities = 279/785 (35%), Positives = 424/785 (54%), Gaps = 104/785 (13%)
Query: 31 TVRYSTFEEDAPGTVIGTLAEDL---HMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGD 87
TV+Y EE GTVIG L+++L + +F++++ + ++V +G L+ G
Sbjct: 31 TVKYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQLPQALPIQVDSEEGLLSTGR 90
Query: 88 AGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEG 147
LDRE+LC Q C+++FDV++ L+HVE++V D+NDH PRFP+ + +E+SE
Sbjct: 91 R-LDREQLCRQWDPCLVSFDVLATGD--LALIHVEIQVLDINDHQPRFPKGEQELEISES 147
Query: 148 AAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRES 207
A++ TRIPL+ +D D G N L T L+ P F +++ D + A+L++++ELDRE
Sbjct: 148 ASLRTRIPLDRALDPDTGPNTLHTYTLS-PSEHFALDVIVGPDETKHAELIVVKELDREI 206
Query: 208 QAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLD 267
+ + L L A D G PP+S T+ + V VLD+ND+SPAF + ++A +E+ EDA G+LL+
Sbjct: 207 HSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLA-LEIQEDAAPGTLLIK 265
Query: 268 LDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQ 327
L A DPD+GPNG+V F PPE F +D ++G++ L P+DYE+ YE+DV+A+
Sbjct: 266 LTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQAR 325
Query: 328 DRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSP 387
D GP P A CKV++++ DVNDN P I +T + P
Sbjct: 326 DLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQP------------------------- 360
Query: 388 AGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGH-EHFRLQPAYAGS 446
SLV E ++S +ALV D DSG NG V C L HFRL+ +
Sbjct: 361 -----------SLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGNT 409
Query: 447 YLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSV 506
Y+++T A+LDRE+ +Y LTL+A+D+G PL + ++++ D NDNAP+F + YEVS
Sbjct: 410 YMLLTNATLDREQWPKYTLTLLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVST 469
Query: 507 RENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRS 566
RENN P +L T+ A D DLG NG+V+YR+ ++ V V++D TG + A RS
Sbjct: 470 RENNLPSLHLITIKAHDADLGINGKVSYRIQDSPVAH-------LVAIDSNTGEVTAQRS 522
Query: 567 FDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANG--SLEVAVP 624
+YE + + ++ A D G P L+SS V V +LD ND+AP +V P ++G SL V V
Sbjct: 523 LNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVN 582
Query: 625 GRT---------------------------AKDTVVARVQARDADEGANGELAFELQQQE 657
T ++ ++ + ARDAD GANGE + ++
Sbjct: 583 ASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIVARDADSGANGEPLYSIRSGN 642
Query: 658 PREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTA--TVSFVVTAGGG 715
F + TG++ + + G + +V+ D G PPL T A V FV +
Sbjct: 643 EAHLFILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFVTSVDHL 702
Query: 716 RGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
R + +R PG+ +S S+L +I + VL G L+LA ++I C
Sbjct: 703 R-----------DSARKPGA---LSMSML----TVICLAVLLGIFGLILALFMSI---CR 741
Query: 776 RRKKE 780
KK+
Sbjct: 742 TEKKD 746
>gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precursor
[Homo sapiens]
Length = 871
Score = 439 bits (1130), Expect = e-123
Identities = 271/748 (36%), Positives = 399/748 (53%), Gaps = 64/748 (8%)
Query: 32 VRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMK--QFNSSLLRVREGDGQLTVGDAG 89
+RY EE GT +G +A+D + ++ RL + N RV G L + +
Sbjct: 31 IRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNP- 89
Query: 90 LDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAA 149
+DRE LCG + C++ + V+ + + EVE+ DVNDHAPRFPR Q+ +E+ E A
Sbjct: 90 IDREALCGLSASCIVPLEFVT--EGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAP 147
Query: 150 VGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQA 209
G R PLE D DVG+N + + RL+ + F ++++ R+DG+ +L+L + LDRE Q+
Sbjct: 148 PGQRFPLEKAQDADVGSNSISSYRLSS-NEHFALDVKKRSDGSLVPELLLEKPLDREKQS 206
Query: 210 AYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLD 269
Y L L A DGG PPRS TA L V VLD ND++PAF Q + + + E AP G +L+ L+
Sbjct: 207 DYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY-RISVLESAPAGMVLIQLN 265
Query: 270 AADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDR 329
A+DPD GP+G+V F F TP R LF L P +G+LTL GP+D+E ++ YE DVRA+D
Sbjct: 266 ASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDG 325
Query: 330 GPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAG 389
G C + V + DVNDNAP I +T + LG
Sbjct: 326 GSPAMEQHCSLRVDLLDVNDNAPYITVT-------------------SELG--------- 357
Query: 390 AGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLV 449
+PE A ++VAL+S D DSG+NG V + H F L+ A+ + +
Sbjct: 358 ----------TLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSL 407
Query: 450 VTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVREN 509
VTA LDRE + Y++ + A D G PPL T R + + D NDN P F + +EV V EN
Sbjct: 408 VTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPEN 467
Query: 510 NPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDY 569
N PG L ++AA D D G N ++Y LLE + S+++S++P TGA++A RSFDY
Sbjct: 468 NRPGDLLCSLAASDPDSGLNALISYSLLEPR--NRDVSASSFISLNPQTGAVHATRSFDY 525
Query: 570 ETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSL-EVAVPGRTA 628
E + L +QA D G+P LSS+ V++ VLD ND+AP ++ P GSL A+P
Sbjct: 526 EQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVG 585
Query: 629 KDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRA 688
++ +V A D D G N ++++L + FA+ R GE+ + + P + +
Sbjct: 586 AGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQ--KL 643
Query: 689 LLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDT 748
++V+ D G PPL+T+ T+ +V+ P P S R SRL
Sbjct: 644 VIVVKDSGSPPLSTSVTL--LVSLEEDTHPVVPDLRES-SAPREGESRL----------- 689
Query: 749 PLIVIIVLAGSCTLLLAAIIAIATTCNR 776
L + + L C + + +A+ + C R
Sbjct: 690 TLYLAVSLVAICFVSFGSFVALLSKCLR 717
>gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precursor
[Homo sapiens]
Length = 938
Score = 439 bits (1130), Expect = e-123
Identities = 271/748 (36%), Positives = 399/748 (53%), Gaps = 64/748 (8%)
Query: 32 VRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMK--QFNSSLLRVREGDGQLTVGDAG 89
+RY EE GT +G +A+D + ++ RL + N RV G L + +
Sbjct: 31 IRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNP- 89
Query: 90 LDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAA 149
+DRE LCG + C++ + V+ + + EVE+ DVNDHAPRFPR Q+ +E+ E A
Sbjct: 90 IDREALCGLSASCIVPLEFVT--EGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAP 147
Query: 150 VGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQA 209
G R PLE D DVG+N + + RL+ + F ++++ R+DG+ +L+L + LDRE Q+
Sbjct: 148 PGQRFPLEKAQDADVGSNSISSYRLSS-NEHFALDVKKRSDGSLVPELLLEKPLDREKQS 206
Query: 210 AYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLD 269
Y L L A DGG PPRS TA L V VLD ND++PAF Q + + + E AP G +L+ L+
Sbjct: 207 DYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY-RISVLESAPAGMVLIQLN 265
Query: 270 AADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDR 329
A+DPD GP+G+V F F TP R LF L P +G+LTL GP+D+E ++ YE DVRA+D
Sbjct: 266 ASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDG 325
Query: 330 GPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAG 389
G C + V + DVNDNAP I +T + LG
Sbjct: 326 GSPAMEQHCSLRVDLLDVNDNAPYITVT-------------------SELG--------- 357
Query: 390 AGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLV 449
+PE A ++VAL+S D DSG+NG V + H F L+ A+ + +
Sbjct: 358 ----------TLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSL 407
Query: 450 VTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVREN 509
VTA LDRE + Y++ + A D G PPL T R + + D NDN P F + +EV V EN
Sbjct: 408 VTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPEN 467
Query: 510 NPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDY 569
N PG L ++AA D D G N ++Y LLE + S+++S++P TGA++A RSFDY
Sbjct: 468 NRPGDLLCSLAASDPDSGLNALISYSLLEPR--NRDVSASSFISLNPQTGAVHATRSFDY 525
Query: 570 ETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSL-EVAVPGRTA 628
E + L +QA D G+P LSS+ V++ VLD ND+AP ++ P GSL A+P
Sbjct: 526 EQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVG 585
Query: 629 KDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRA 688
++ +V A D D G N ++++L + FA+ R GE+ + + P + +
Sbjct: 586 AGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQ--KL 643
Query: 689 LLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDT 748
++V+ D G PPL+T+ T+ +V+ P P S R SRL
Sbjct: 644 VIVVKDSGSPPLSTSVTL--LVSLEEDTHPVVPDLRES-SAPREGESRL----------- 689
Query: 749 PLIVIIVLAGSCTLLLAAIIAIATTCNR 776
L + + L C + + +A+ + C R
Sbjct: 690 TLYLAVSLVAICFVSFGSFVALLSKCLR 717
>gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo
sapiens]
Length = 807
Score = 434 bits (1116), Expect = e-121
Identities = 280/772 (36%), Positives = 414/772 (53%), Gaps = 68/772 (8%)
Query: 14 PLQLFSLCWVLSVAQSKT----VRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMK 67
P QL L W+L +A +T + YS EE GT +G +A+DL ++++ FR+
Sbjct: 11 PRQL--LLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVAS 68
Query: 68 QFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRD 127
+ + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ HVEV+VRD
Sbjct: 69 KRHGDLLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVFHVEVKVRD 125
Query: 128 VNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQT 187
+ND+ P FP ++ + ++E TR PL+ D D+G N T RL +P+ F ++ Q
Sbjct: 126 INDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRL-DPNDYFTLDAQN 184
Query: 188 RADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247
+ LVL + LDRE +SL L A DGG+P + T L + +LD ND++P F Q
Sbjct: 185 SLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQ 244
Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLT 307
+V +V + E+A G+L++ L+A DPD+G NGD+V++F P F ++P +G +
Sbjct: 245 -SVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIR 303
Query: 308 LAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPAT 367
G +D+E + YE+ V A D+G P A C ++V + DVNDNAP++ IT L+ P T
Sbjct: 304 TKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDT 363
Query: 368 SPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQV 427
P A ++AL+S SDRDSG+NGQV
Sbjct: 364 QPSA--------------------------------------IIALISVSDRDSGSNGQV 385
Query: 428 RCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRV 487
C L H F+L Y Y +V ++LDRE ++ Y L + A D G+P L +V V
Sbjct: 386 TCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGV 445
Query: 488 GDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGA 547
D NDNAP F +P Y V V+ENNPPG ++ TV+A+D D N V+Y L+E VG A
Sbjct: 446 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGER--A 503
Query: 548 VSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAP 607
+S+YVSV +G +YAL+ D+E L L ++ A D G P L S+ +QV VLD+ND+AP
Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAP 563
Query: 608 VLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREAFA 663
L+ P A G++ +P VVA+V+A DAD G N L++ELQ R F
Sbjct: 564 ALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFR 623
Query: 664 IGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPAS 723
+G TGEI T L E R L+++ D G P LT TATV + G AP +
Sbjct: 624 VGLYTGEISTTRPL-DEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESG----QAPQA 678
Query: 724 AGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
+ SR +G +++ + LI I + A S L+L ++ A C+
Sbjct: 679 S-----SRASAGAVGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCS 724
>gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo
sapiens]
Length = 950
Score = 434 bits (1116), Expect = e-121
Identities = 280/772 (36%), Positives = 414/772 (53%), Gaps = 68/772 (8%)
Query: 14 PLQLFSLCWVLSVAQSKT----VRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMK 67
P QL L W+L +A +T + YS EE GT +G +A+DL ++++ FR+
Sbjct: 11 PRQL--LLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVAS 68
Query: 68 QFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRD 127
+ + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ HVEV+VRD
Sbjct: 69 KRHGDLLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVFHVEVKVRD 125
Query: 128 VNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQT 187
+ND+ P FP ++ + ++E TR PL+ D D+G N T RL +P+ F ++ Q
Sbjct: 126 INDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRL-DPNDYFTLDAQN 184
Query: 188 RADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247
+ LVL + LDRE +SL L A DGG+P + T L + +LD ND++P F Q
Sbjct: 185 SLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQ 244
Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLT 307
+V +V + E+A G+L++ L+A DPD+G NGD+V++F P F ++P +G +
Sbjct: 245 -SVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIR 303
Query: 308 LAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPAT 367
G +D+E + YE+ V A D+G P A C ++V + DVNDNAP++ IT L+ P T
Sbjct: 304 TKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDT 363
Query: 368 SPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQV 427
P A ++AL+S SDRDSG+NGQV
Sbjct: 364 QPSA--------------------------------------IIALISVSDRDSGSNGQV 385
Query: 428 RCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRV 487
C L H F+L Y Y +V ++LDRE ++ Y L + A D G+P L +V V
Sbjct: 386 TCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGV 445
Query: 488 GDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGA 547
D NDNAP F +P Y V V+ENNPPG ++ TV+A+D D N V+Y L+E VG A
Sbjct: 446 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGER--A 503
Query: 548 VSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAP 607
+S+YVSV +G +YAL+ D+E L L ++ A D G P L S+ +QV VLD+ND+AP
Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAP 563
Query: 608 VLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREAFA 663
L+ P A G++ +P VVA+V+A DAD G N L++ELQ R F
Sbjct: 564 ALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFR 623
Query: 664 IGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPAS 723
+G TGEI T L E R L+++ D G P LT TATV + G AP +
Sbjct: 624 VGLYTGEISTTRPL-DEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESG----QAPQA 678
Query: 724 AGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
+ SR +G +++ + LI I + A S L+L ++ A C+
Sbjct: 679 S-----SRASAGAVGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCS 724
>gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo
sapiens]
Length = 814
Score = 432 bits (1110), Expect = e-120
Identities = 282/774 (36%), Positives = 412/774 (53%), Gaps = 65/774 (8%)
Query: 8 GSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRL 65
GS L L L W + Q + YS EE GT +G +A+DL ++++ FR+
Sbjct: 10 GSWRLLLLLLLLAAWKVGSGQ---LHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRV 66
Query: 66 MKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEV 125
+ + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ HV+VEV
Sbjct: 67 ASKRHRDLLEVSLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVFHVDVEV 123
Query: 126 RDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVEL 185
+DVND+ P F + VSE +R PLE D DVGAN + T RL+ H F +++
Sbjct: 124 KDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSS-HDYFMLDV 182
Query: 186 QTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAF 245
++ D + +LVL + LDRE A+ L L A DGG+P + T L V VLD ND++P F
Sbjct: 183 NSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTF 242
Query: 246 PQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGR 305
Q EV + E+A G+ ++ L+A+DPDEG NG + ++F + F +D +G
Sbjct: 243 EQSEY-EVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGE 301
Query: 306 LTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAP 365
+ + G +D+E+++ Y++ + A D+G P A C V+VRI D NDN P+IA+T L+ P
Sbjct: 302 IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLP--- 358
Query: 366 ATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANG 425
V E A +++AL+S +D DSGANG
Sbjct: 359 -----------------------------------VREDAQFGTVIALISVNDLDSGANG 383
Query: 426 QVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTV 485
QV C+L H F+L + Y +V ++LDRER++ Y L + A D G+P L +V
Sbjct: 384 QVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSV 443
Query: 486 RVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAG 545
V D NDNAP F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E VG
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER- 502
Query: 546 GAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDH 605
++S+Y+SV +G +YAL+ D+E L L ++ A D G P L S+ +QV VLD+ND+
Sbjct: 503 -SLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDN 561
Query: 606 APVLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQ--QQEPREA 661
AP L+ P G+ VP VVA+V+A DAD G N L++ELQ PR
Sbjct: 562 APALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIP 621
Query: 662 FAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAP 721
F +G TGEI T L + R R L+++ D G P LT TATV V G+ P A
Sbjct: 622 FRVGLYTGEISTTRVLDEADSPR-HRLLVLVKDHGEPALTATATV-LVSLVESGQAPKA- 678
Query: 722 ASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
SR LG +++ + LI I + A S L+L ++ A C+
Sbjct: 679 -------SSRQSAGVLGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCS 724
>gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens]
Length = 950
Score = 432 bits (1110), Expect = e-120
Identities = 282/774 (36%), Positives = 412/774 (53%), Gaps = 65/774 (8%)
Query: 8 GSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRL 65
GS L L L W + Q + YS EE GT +G +A+DL ++++ FR+
Sbjct: 10 GSWRLLLLLLLLAAWKVGSGQ---LHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRV 66
Query: 66 MKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEV 125
+ + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ HV+VEV
Sbjct: 67 ASKRHRDLLEVSLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVFHVDVEV 123
Query: 126 RDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVEL 185
+DVND+ P F + VSE +R PLE D DVGAN + T RL+ H F +++
Sbjct: 124 KDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSS-HDYFMLDV 182
Query: 186 QTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAF 245
++ D + +LVL + LDRE A+ L L A DGG+P + T L V VLD ND++P F
Sbjct: 183 NSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTF 242
Query: 246 PQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGR 305
Q EV + E+A G+ ++ L+A+DPDEG NG + ++F + F +D +G
Sbjct: 243 EQSEY-EVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGE 301
Query: 306 LTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAP 365
+ + G +D+E+++ Y++ + A D+G P A C V+VRI D NDN P+IA+T L+ P
Sbjct: 302 IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLP--- 358
Query: 366 ATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANG 425
V E A +++AL+S +D DSGANG
Sbjct: 359 -----------------------------------VREDAQFGTVIALISVNDLDSGANG 383
Query: 426 QVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTV 485
QV C+L H F+L + Y +V ++LDRER++ Y L + A D G+P L +V
Sbjct: 384 QVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSV 443
Query: 486 RVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAG 545
V D NDNAP F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E VG
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER- 502
Query: 546 GAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDH 605
++S+Y+SV +G +YAL+ D+E L L ++ A D G P L S+ +QV VLD+ND+
Sbjct: 503 -SLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDN 561
Query: 606 APVLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQ--QQEPREA 661
AP L+ P G+ VP VVA+V+A DAD G N L++ELQ PR
Sbjct: 562 APALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIP 621
Query: 662 FAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAP 721
F +G TGEI T L + R R L+++ D G P LT TATV V G+ P A
Sbjct: 622 FRVGLYTGEISTTRVLDEADSPR-HRLLVLVKDHGEPALTATATV-LVSLVESGQAPKA- 678
Query: 722 ASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
SR LG +++ + LI I + A S L+L ++ A C+
Sbjct: 679 -------SSRQSAGVLGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCS 724
>gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo
sapiens]
Length = 824
Score = 426 bits (1094), Expect = e-119
Identities = 279/806 (34%), Positives = 422/806 (52%), Gaps = 75/806 (9%)
Query: 29 SKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSLLRVREGDGQLTVG 86
S +RYS EE GT +G +A+DL +++ FR+ + + LL V +G L V
Sbjct: 28 SGQLRYSVPEEAKHGTFVGRIAQDLGLELEELVPRLFRVASKRHGDLLEVNLQNGILFV- 86
Query: 87 DAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSE 146
++ +DRE LCG++ +C + +V+ ++ HVEVEV+D+ND+ P FP + E
Sbjct: 87 NSRIDREELCGRSAECSIHVEVIV--DRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPE 144
Query: 147 GAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRE 206
+ +R PLE D D+G N L + +L+ F +++Q + ++ LVL + LDRE
Sbjct: 145 SRLLDSRFPLEGASDADIGVNALLSYKLSSSEF-FFLDIQANDELSESLSLVLGKSLDRE 203
Query: 207 SQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLL 266
A +L LVA DGG+P + T + ++VLD ND+ P F Q +V +V+L E+ G+L++
Sbjct: 204 ETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQ-SVYKVKLLENTANGTLVV 262
Query: 267 DLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRA 326
L+A+D DEGPN ++V++ G+ + F +DP SG + G +DYE +YE+ V A
Sbjct: 263 KLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTA 322
Query: 327 QDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASS 386
D+G + CK+ +++ D+NDN P+++IT L+ P
Sbjct: 323 TDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLP------------------------ 358
Query: 387 PAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGS 446
+ E A+ +++AL++ SDRDSG NG V C+L H F+L +
Sbjct: 359 --------------ISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNY 404
Query: 447 YLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSV 506
Y +V ++LDRE ++ Y L + A D G+P L ++ V D NDNAP F +P Y V V
Sbjct: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFV 464
Query: 507 RENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRS 566
+ENNPPG ++ TV+A D D N V+Y L+E VG A+S+YVSV +G +YAL+
Sbjct: 465 KENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGER--ALSSYVSVHAESGKVYALQP 522
Query: 567 FDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP--APANGSLEVAVP 624
D+E + L ++ A D G P L S+ +QV VLD+ND+AP L+ P A G++ VP
Sbjct: 523 LDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVP 582
Query: 625 GRTAKDTVVARVQARDADEGANGELAFELQ--QQEPREAFAIGRRTGEILLTGDLSQEPP 682
VVA+V+A DAD G N L++ELQ R F +G TGEI T L +
Sbjct: 583 WSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVGLYTGEISTTRALDEADS 642
Query: 683 GRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGS 742
R R L+++ D G P LT TATV V G+ P A + A +G +GS
Sbjct: 643 PR-HRLLVLVKDHGEPALTATATV-LVSLVESGQAPKASSRAW-----------VGAAGS 689
Query: 743 --VLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEPYGASPGFGKEPAPPVAVWK 800
L ++I + A S L+L ++ A C+ E GA + P P V
Sbjct: 690 EATLVDVNVYLIIAICAVSSLLVLTVLLYTALRCSVPPTE--GA-----RAPGKPTLVCS 742
Query: 801 G--HSFNTISGREAEKFSGKDSGKGD 824
S++ R SG+D K D
Sbjct: 743 SAVGSWSYSQQRRQRVCSGEDPPKTD 768
>gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens]
Length = 948
Score = 426 bits (1094), Expect = e-119
Identities = 279/806 (34%), Positives = 422/806 (52%), Gaps = 75/806 (9%)
Query: 29 SKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSLLRVREGDGQLTVG 86
S +RYS EE GT +G +A+DL +++ FR+ + + LL V +G L V
Sbjct: 28 SGQLRYSVPEEAKHGTFVGRIAQDLGLELEELVPRLFRVASKRHGDLLEVNLQNGILFV- 86
Query: 87 DAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSE 146
++ +DRE LCG++ +C + +V+ ++ HVEVEV+D+ND+ P FP + E
Sbjct: 87 NSRIDREELCGRSAECSIHVEVIV--DRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPE 144
Query: 147 GAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRE 206
+ +R PLE D D+G N L + +L+ F +++Q + ++ LVL + LDRE
Sbjct: 145 SRLLDSRFPLEGASDADIGVNALLSYKLSSSEF-FFLDIQANDELSESLSLVLGKSLDRE 203
Query: 207 SQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLL 266
A +L LVA DGG+P + T + ++VLD ND+ P F Q +V +V+L E+ G+L++
Sbjct: 204 ETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQ-SVYKVKLLENTANGTLVV 262
Query: 267 DLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRA 326
L+A+D DEGPN ++V++ G+ + F +DP SG + G +DYE +YE+ V A
Sbjct: 263 KLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTA 322
Query: 327 QDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASS 386
D+G + CK+ +++ D+NDN P+++IT L+ P
Sbjct: 323 TDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLP------------------------ 358
Query: 387 PAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGS 446
+ E A+ +++AL++ SDRDSG NG V C+L H F+L +
Sbjct: 359 --------------ISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNY 404
Query: 447 YLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSV 506
Y +V ++LDRE ++ Y L + A D G+P L ++ V D NDNAP F +P Y V V
Sbjct: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFV 464
Query: 507 RENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRS 566
+ENNPPG ++ TV+A D D N V+Y L+E VG A+S+YVSV +G +YAL+
Sbjct: 465 KENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGER--ALSSYVSVHAESGKVYALQP 522
Query: 567 FDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP--APANGSLEVAVP 624
D+E + L ++ A D G P L S+ +QV VLD+ND+AP L+ P A G++ VP
Sbjct: 523 LDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVP 582
Query: 625 GRTAKDTVVARVQARDADEGANGELAFELQ--QQEPREAFAIGRRTGEILLTGDLSQEPP 682
VVA+V+A DAD G N L++ELQ R F +G TGEI T L +
Sbjct: 583 WSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVGLYTGEISTTRALDEADS 642
Query: 683 GRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGS 742
R R L+++ D G P LT TATV V G+ P A + A +G +GS
Sbjct: 643 PR-HRLLVLVKDHGEPALTATATV-LVSLVESGQAPKASSRAW-----------VGAAGS 689
Query: 743 --VLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEPYGASPGFGKEPAPPVAVWK 800
L ++I + A S L+L ++ A C+ E GA + P P V
Sbjct: 690 EATLVDVNVYLIIAICAVSSLLVLTVLLYTALRCSVPPTE--GA-----RAPGKPTLVCS 742
Query: 801 G--HSFNTISGREAEKFSGKDSGKGD 824
S++ R SG+D K D
Sbjct: 743 SAVGSWSYSQQRRQRVCSGEDPPKTD 768
>gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens]
Length = 936
Score = 426 bits (1094), Expect = e-119
Identities = 273/770 (35%), Positives = 410/770 (53%), Gaps = 65/770 (8%)
Query: 20 LCWVLSV---AQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSLL 74
L W+L A S + YS EE GT +G +A+DL ++++ FR+ + LL
Sbjct: 15 LLWLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGDLL 74
Query: 75 RVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPR 134
V +G L V ++ +DRE LC + +C + +V+ ++ HVEV V+D+ND+ PR
Sbjct: 75 EVNLQNGILFV-NSRIDREELCRRRAECSIHLEVIV--DRPLQVFHVEVAVKDINDNPPR 131
Query: 135 FPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQC 194
F R + + + E +R PLE D D+GAN RL P+ F ++++T +
Sbjct: 132 FSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRL-NPNEYFDLDVKTNEEETNF 190
Query: 195 ADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVE 254
+LVL + LDRE + L ++A DGG+P + T L + VLDAND++P F + ++ V
Sbjct: 191 LELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDK-SIYNVR 249
Query: 255 LAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDY 314
L E+AP G+L++ L+A+D DEG N ++V+ F + + F ++ +G + + G +DY
Sbjct: 250 LLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDY 309
Query: 315 ERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAA 374
E ++YE+++ A D+ P + CKV+V++ DVNDN P++AIT L P
Sbjct: 310 EDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLP------------ 357
Query: 375 AAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGH 434
V E A +++AL+S SDRDSGANGQV C+L H
Sbjct: 358 --------------------------VKEDAPLSTVIALISVSDRDSGANGQVTCSLMPH 391
Query: 435 EHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNA 494
F+L + Y +V ++LDRE ++ Y L + A D G+P L +V V D NDNA
Sbjct: 392 VPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNA 451
Query: 495 PLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSV 554
P F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E VG +S+YVSV
Sbjct: 452 PAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER--PLSSYVSV 509
Query: 555 DPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP-- 612
+G +YAL+ D+E + L ++ A D G P L S+ +QV VLD+ND+AP L+ P
Sbjct: 510 HAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRV 569
Query: 613 APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQ--EPREAFAIGRRTGE 670
G++ VP VVA+V+A D D G N L++ELQ R F +G TGE
Sbjct: 570 GGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRVGLYTGE 629
Query: 671 ILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERS 730
I T L + R R L+++ D G PPLT TATV V G+ P A S
Sbjct: 630 ISTTRSLDETEAPR-HRLLVLVKDHGEPPLTATATV-LVSLVESGQAPKA--------SS 679
Query: 731 RPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
R +G +++ + LI I + A S L+L ++ A C+ + E
Sbjct: 680 RASAGAVGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSAQPTE 728
>gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo
sapiens]
Length = 816
Score = 426 bits (1094), Expect = e-119
Identities = 273/770 (35%), Positives = 410/770 (53%), Gaps = 65/770 (8%)
Query: 20 LCWVLSV---AQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSLL 74
L W+L A S + YS EE GT +G +A+DL ++++ FR+ + LL
Sbjct: 15 LLWLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGDLL 74
Query: 75 RVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPR 134
V +G L V ++ +DRE LC + +C + +V+ ++ HVEV V+D+ND+ PR
Sbjct: 75 EVNLQNGILFV-NSRIDREELCRRRAECSIHLEVIV--DRPLQVFHVEVAVKDINDNPPR 131
Query: 135 FPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQC 194
F R + + + E +R PLE D D+GAN RL P+ F ++++T +
Sbjct: 132 FSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRL-NPNEYFDLDVKTNEEETNF 190
Query: 195 ADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVE 254
+LVL + LDRE + L ++A DGG+P + T L + VLDAND++P F + ++ V
Sbjct: 191 LELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDK-SIYNVR 249
Query: 255 LAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDY 314
L E+AP G+L++ L+A+D DEG N ++V+ F + + F ++ +G + + G +DY
Sbjct: 250 LLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDY 309
Query: 315 ERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAA 374
E ++YE+++ A D+ P + CKV+V++ DVNDN P++AIT L P
Sbjct: 310 EDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLP------------ 357
Query: 375 AAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGH 434
V E A +++AL+S SDRDSGANGQV C+L H
Sbjct: 358 --------------------------VKEDAPLSTVIALISVSDRDSGANGQVTCSLMPH 391
Query: 435 EHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNA 494
F+L + Y +V ++LDRE ++ Y L + A D G+P L +V V D NDNA
Sbjct: 392 VPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNA 451
Query: 495 PLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSV 554
P F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E VG +S+YVSV
Sbjct: 452 PAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER--PLSSYVSV 509
Query: 555 DPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP-- 612
+G +YAL+ D+E + L ++ A D G P L S+ +QV VLD+ND+AP L+ P
Sbjct: 510 HAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRV 569
Query: 613 APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQ--EPREAFAIGRRTGE 670
G++ VP VVA+V+A D D G N L++ELQ R F +G TGE
Sbjct: 570 GGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRVGLYTGE 629
Query: 671 ILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERS 730
I T L + R R L+++ D G PPLT TATV V G+ P A S
Sbjct: 630 ISTTRSLDETEAPR-HRLLVLVKDHGEPPLTATATV-LVSLVESGQAPKA--------SS 679
Query: 731 RPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
R +G +++ + LI I + A S L+L ++ A C+ + E
Sbjct: 680 RASAGAVGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSAQPTE 728
>gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precursor
[Homo sapiens]
Length = 932
Score = 423 bits (1088), Expect = e-118
Identities = 271/772 (35%), Positives = 413/772 (53%), Gaps = 75/772 (9%)
Query: 32 VRYSTFEEDAPGTVIGTLAEDLHMKVS--GDTSFRLMKQFNSSLLRVREGDGQLTVGDAG 89
+RYS EE G+ +G ++ DL ++ + R++ + + L + G L
Sbjct: 31 IRYSVPEELEKGSRVGDISRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGR- 89
Query: 90 LDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAA 149
+DRE LC A +C L D++ +++ ++ VEVEVRD+ND+AP F +++ +++SE AA
Sbjct: 90 IDREELCMGAIKCQLNLDILM--EDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAA 147
Query: 150 VGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQA 209
R PL D D+G N LQ+ L+ P++ F + +Q ADG++ +LVL + LDRE +A
Sbjct: 148 TEMRFPLPHAWDPDIGKNSLQSYELS-PNTHFSLIVQNGADGSKYPELVLKRALDREEKA 206
Query: 210 AYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLD 269
A+ L L A DGG P R+ TA + V VLDAND++PAF Q + E+ +G+ LL ++
Sbjct: 207 AHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEY-RASVPENLALGTQLLVVN 265
Query: 270 AADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDR 329
A DPDEG N +V ++F +A ++F+LD SG ++ G +D+E Y+++V+A D
Sbjct: 266 ATDPDEGVNAEVRYSF-RYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDN 324
Query: 330 GPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAG 389
+A KV++ + DVNDNAP++ +T LA
Sbjct: 325 AG--YSARAKVLITVLDVNDNAPEVVLTSLA----------------------------- 353
Query: 390 AGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLV 449
S VPE + R +L+AL++ +D+DS NGQV C + G+ F+L+ +Y Y +
Sbjct: 354 ---------SSVPENSPRGTLIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSL 404
Query: 450 VTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVREN 509
VT LDRE++ YN+T+ A DRG PPL T ++ V D NDN P+F + Y + EN
Sbjct: 405 VTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPEN 464
Query: 510 NPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDY 569
NP G L +V A D D N Q+TY L E + G ++S+YVS++ TG +YAL SFDY
Sbjct: 465 NPRGVSLVSVTAHDPDCEENAQITYSLAENTI--QGASLSSYVSINSDTGVLYALSSFDY 522
Query: 570 ETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPA-PANGSLEVAVPGRTA 628
E R L V++ A D G P LSS+ + + VLDQND+AP +++PA P +GS V + R+A
Sbjct: 523 EQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSA 582
Query: 629 K-DTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEI-----LLTGDLSQEPP 682
+ +V +V A D D G N L++ L + F++G TGE+ LL D ++
Sbjct: 583 EPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQ-- 640
Query: 683 GRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGS 742
++ + D G+PPL+ T T++ V + A S SP S L
Sbjct: 641 ----SLVVAVQDHGQPPLSATVTLTVAVADSIPQVLADLGSLESPANSETSDLTL----- 691
Query: 743 VLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEPYGASPGFGKEPAP 794
+V+ V A SC L I+ +A R K + G G AP
Sbjct: 692 -------YLVVAVAAVSCVFLAFVILLLALRLRRWHKSRLLQASGGGLTGAP 736
Score = 90.5 bits (223), Expect = 7e-18
Identities = 95/317 (29%), Positives = 135/317 (42%), Gaps = 55/317 (17%)
Query: 394 EAGATSL---VPEGAARESLVALVSTSDRDSG------ANGQVRCALYGHEH-FRLQPAY 443
E G T + VPE + S V +S RD G A VR G F L P
Sbjct: 25 ETGCTQIRYSVPEELEKGSRVGDIS---RDLGLEPRELAERGVRIIPRGRTQLFALNPR- 80
Query: 444 AGSYLVVTAASLDRERIA------EYNLTLVAEDRGAPPLRTVRPY--TVRVGDENDNAP 495
+GS +VTA +DRE + + NL ++ ED+ V+ Y V V D NDNAP
Sbjct: 81 SGS--LVTAGRIDREELCMGAIKCQLNLDILMEDK-------VKIYGVEVEVRDINDNAP 131
Query: 496 LFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVD 555
F E+ + EN A D D+G+N +Y L + +T+ S+
Sbjct: 132 YFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYEL----------SPNTHFSLI 181
Query: 556 PATGA-------IYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPV 608
GA + R+ D E + + ASDGG P + +A ++V VLD ND+AP
Sbjct: 182 VQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPA 241
Query: 609 LVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREA--FAIGR 666
P +VP A T + V A D DEG N E+ + + + + A F +
Sbjct: 242 FAQP-----EYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDC 296
Query: 667 RTGEILLTGDLSQEPPG 683
+G I G+L E G
Sbjct: 297 NSGTISTIGELDHEESG 313
>gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 423 bits (1088), Expect = e-118
Identities = 271/772 (35%), Positives = 413/772 (53%), Gaps = 75/772 (9%)
Query: 32 VRYSTFEEDAPGTVIGTLAEDLHMKVS--GDTSFRLMKQFNSSLLRVREGDGQLTVGDAG 89
+RYS EE G+ +G ++ DL ++ + R++ + + L + G L
Sbjct: 31 IRYSVPEELEKGSRVGDISRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGR- 89
Query: 90 LDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAA 149
+DRE LC A +C L D++ +++ ++ VEVEVRD+ND+AP F +++ +++SE AA
Sbjct: 90 IDREELCMGAIKCQLNLDILM--EDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAA 147
Query: 150 VGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQA 209
R PL D D+G N LQ+ L+ P++ F + +Q ADG++ +LVL + LDRE +A
Sbjct: 148 TEMRFPLPHAWDPDIGKNSLQSYELS-PNTHFSLIVQNGADGSKYPELVLKRALDREEKA 206
Query: 210 AYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLD 269
A+ L L A DGG P R+ TA + V VLDAND++PAF Q + E+ +G+ LL ++
Sbjct: 207 AHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEY-RASVPENLALGTQLLVVN 265
Query: 270 AADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDR 329
A DPDEG N +V ++F +A ++F+LD SG ++ G +D+E Y+++V+A D
Sbjct: 266 ATDPDEGVNAEVRYSF-RYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDN 324
Query: 330 GPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAG 389
+A KV++ + DVNDNAP++ +T LA
Sbjct: 325 AG--YSARAKVLITVLDVNDNAPEVVLTSLA----------------------------- 353
Query: 390 AGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLV 449
S VPE + R +L+AL++ +D+DS NGQV C + G+ F+L+ +Y Y +
Sbjct: 354 ---------SSVPENSPRGTLIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSL 404
Query: 450 VTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVREN 509
VT LDRE++ YN+T+ A DRG PPL T ++ V D NDN P+F + Y + EN
Sbjct: 405 VTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPEN 464
Query: 510 NPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDY 569
NP G L +V A D D N Q+TY L E + G ++S+YVS++ TG +YAL SFDY
Sbjct: 465 NPRGVSLVSVTAHDPDCEENAQITYSLAENTI--QGASLSSYVSINSDTGVLYALSSFDY 522
Query: 570 ETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPA-PANGSLEVAVPGRTA 628
E R L V++ A D G P LSS+ + + VLDQND+AP +++PA P +GS V + R+A
Sbjct: 523 EQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSA 582
Query: 629 K-DTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEI-----LLTGDLSQEPP 682
+ +V +V A D D G N L++ L + F++G TGE+ LL D ++
Sbjct: 583 EPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQ-- 640
Query: 683 GRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGS 742
++ + D G+PPL+ T T++ V + A S SP S L
Sbjct: 641 ----SLVVAVQDHGQPPLSATVTLTVAVADSIPQVLADLGSLESPANSETSDLTL----- 691
Query: 743 VLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEPYGASPGFGKEPAP 794
+V+ V A SC L I+ +A R K + G G AP
Sbjct: 692 -------YLVVAVAAVSCVFLAFVILLLALRLRRWHKSRLLQASGGGLTGAP 736
Score = 90.5 bits (223), Expect = 7e-18
Identities = 95/317 (29%), Positives = 135/317 (42%), Gaps = 55/317 (17%)
Query: 394 EAGATSL---VPEGAARESLVALVSTSDRDSG------ANGQVRCALYGHEH-FRLQPAY 443
E G T + VPE + S V +S RD G A VR G F L P
Sbjct: 25 ETGCTQIRYSVPEELEKGSRVGDIS---RDLGLEPRELAERGVRIIPRGRTQLFALNPR- 80
Query: 444 AGSYLVVTAASLDRERIA------EYNLTLVAEDRGAPPLRTVRPY--TVRVGDENDNAP 495
+GS +VTA +DRE + + NL ++ ED+ V+ Y V V D NDNAP
Sbjct: 81 SGS--LVTAGRIDREELCMGAIKCQLNLDILMEDK-------VKIYGVEVEVRDINDNAP 131
Query: 496 LFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVD 555
F E+ + EN A D D+G+N +Y L + +T+ S+
Sbjct: 132 YFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYEL----------SPNTHFSLI 181
Query: 556 PATGA-------IYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPV 608
GA + R+ D E + + ASDGG P + +A ++V VLD ND+AP
Sbjct: 182 VQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPA 241
Query: 609 LVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREA--FAIGR 666
P +VP A T + V A D DEG N E+ + + + + A F +
Sbjct: 242 FAQP-----EYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDC 296
Query: 667 RTGEILLTGDLSQEPPG 683
+G I G+L E G
Sbjct: 297 NSGTISTIGELDHEESG 313
>gi|14165400 protocadherin alpha 1 isoform 2 precursor [Homo
sapiens]
Length = 807
Score = 422 bits (1085), Expect = e-118
Identities = 275/768 (35%), Positives = 409/768 (53%), Gaps = 70/768 (9%)
Query: 20 LCWVLSVAQ----SKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSL 73
L W+L +A S + YS EE GT +G +A+DL ++++ FR+ + + L
Sbjct: 15 LLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDL 74
Query: 74 LRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAP 133
L V +G L V ++ +DRE LC + +C + ++++ ++ HVEV+V+D+ND+ P
Sbjct: 75 LEVNLQNGILFV-NSRIDREELCQWSAECSIHLELIA--DRPLQVFHVEVKVKDINDNPP 131
Query: 134 RFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQ 193
F + + + E + +R P+E D D+GAN L T L+ P F ++++ + ++
Sbjct: 132 VFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLS-PSDYFSLDVEASDELSK 190
Query: 194 CADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEV 253
L L + LDRE L L A DGG+P T L + VLD ND++P F Q AV V
Sbjct: 191 SLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQ-AVYRV 249
Query: 254 ELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVD 313
L E G+L+ L+A+D DEG NG+VVF+F + + + F++D SG + L +D
Sbjct: 250 HLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLD 309
Query: 314 YERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAA 373
YE +YE+ V+A D+G P + CKV+V++ DVNDNAP++A+T L P
Sbjct: 310 YEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLP----------- 358
Query: 374 AAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYG 433
+ E A +++AL++ SDRDSGANGQV C+L
Sbjct: 359 ---------------------------IREDAPLSTVIALITVSDRDSGANGQVTCSLMP 391
Query: 434 HEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDN 493
H F+L + Y +V ++LDRE ++ Y L + A D G+P L +V V D NDN
Sbjct: 392 HVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDN 451
Query: 494 APLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVS 553
AP F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E VG A+S YVS
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER--ALSNYVS 509
Query: 554 VDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPA 613
V +G +YAL+ D+E L L ++ A D G P L S+ +QV VLD+ND+AP L+ P
Sbjct: 510 VHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPR 569
Query: 614 PAN--GSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREAFAIGRRTG 669
G++ VP VVA+V+A DAD G N L++ELQ R F +G TG
Sbjct: 570 VGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFRVGLYTG 629
Query: 670 EILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPER 729
EI T L + R +R L+++ D G P LT TATV V G+ P A + A
Sbjct: 630 EISTTRVLDEADLSR-YRLLVLVKDHGEPALTATATV-LVSLVESGQAPKASSRAS---- 683
Query: 730 SRPPGSRLGVSG--SVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
+GV+G + L ++I + A S L+L ++ A C+
Sbjct: 684 -------VGVAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCS 724
>gi|9256582 protocadherin alpha 1 isoform 1 precursor [Homo sapiens]
Length = 950
Score = 422 bits (1085), Expect = e-118
Identities = 275/768 (35%), Positives = 409/768 (53%), Gaps = 70/768 (9%)
Query: 20 LCWVLSVAQ----SKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSL 73
L W+L +A S + YS EE GT +G +A+DL ++++ FR+ + + L
Sbjct: 15 LLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDL 74
Query: 74 LRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAP 133
L V +G L V ++ +DRE LC + +C + ++++ ++ HVEV+V+D+ND+ P
Sbjct: 75 LEVNLQNGILFV-NSRIDREELCQWSAECSIHLELIA--DRPLQVFHVEVKVKDINDNPP 131
Query: 134 RFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQ 193
F + + + E + +R P+E D D+GAN L T L+ P F ++++ + ++
Sbjct: 132 VFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLS-PSDYFSLDVEASDELSK 190
Query: 194 CADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEV 253
L L + LDRE L L A DGG+P T L + VLD ND++P F Q AV V
Sbjct: 191 SLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQ-AVYRV 249
Query: 254 ELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVD 313
L E G+L+ L+A+D DEG NG+VVF+F + + + F++D SG + L +D
Sbjct: 250 HLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLD 309
Query: 314 YERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAA 373
YE +YE+ V+A D+G P + CKV+V++ DVNDNAP++A+T L P
Sbjct: 310 YEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLP----------- 358
Query: 374 AAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYG 433
+ E A +++AL++ SDRDSGANGQV C+L
Sbjct: 359 ---------------------------IREDAPLSTVIALITVSDRDSGANGQVTCSLMP 391
Query: 434 HEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDN 493
H F+L + Y +V ++LDRE ++ Y L + A D G+P L +V V D NDN
Sbjct: 392 HVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDN 451
Query: 494 APLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVS 553
AP F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E VG A+S YVS
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER--ALSNYVS 509
Query: 554 VDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPA 613
V +G +YAL+ D+E L L ++ A D G P L S+ +QV VLD+ND+AP L+ P
Sbjct: 510 VHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPR 569
Query: 614 PAN--GSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREAFAIGRRTG 669
G++ VP VVA+V+A DAD G N L++ELQ R F +G TG
Sbjct: 570 VGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFRVGLYTG 629
Query: 670 EILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPER 729
EI T L + R +R L+++ D G P LT TATV V G+ P A + A
Sbjct: 630 EISTTRVLDEADLSR-YRLLVLVKDHGEPALTATATV-LVSLVESGQAPKASSRAS---- 683
Query: 730 SRPPGSRLGVSG--SVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
+GV+G + L ++I + A S L+L ++ A C+
Sbjct: 684 -------VGVAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCS 724
>gi|14165381 protocadherin alpha 10 isoform 2 precursor [Homo
sapiens]
Length = 844
Score = 421 bits (1083), Expect = e-117
Identities = 275/780 (35%), Positives = 416/780 (53%), Gaps = 68/780 (8%)
Query: 8 GSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRL 65
G CL L W + Q + YS +EE GT +G +A+DL ++++ FR+
Sbjct: 9 GVQCLLLSLLLLAAWEVGSGQ---LHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRV 65
Query: 66 MKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEV 125
+ + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ HV+VEV
Sbjct: 66 ASKRHGDLLEVNLQNGILFV-NSRIDREELCGRSVECSIHLEVIV--DRPLQVFHVDVEV 122
Query: 126 RDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVEL 185
+D+ND+ PRF + + + E + +R PLE D DVG N L T +L+ P+ F +++
Sbjct: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLS-PNEYFVLDI 181
Query: 186 QTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAF 245
+ D + LVL + LDRE L L A DGG+P + + +L + VLDAND++P F
Sbjct: 182 INKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIF 241
Query: 246 PQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGR 305
+ V EV++ E+ +L++ L+A+D DEG N +++++F + PP RR F ++ R+G
Sbjct: 242 DR-PVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE 300
Query: 306 LTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAP 365
+ + +D+E +TYE+ V D+G P C V+V + D NDN+P++ +T L+ P
Sbjct: 301 IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLP--- 357
Query: 366 ATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANG 425
V E A +++AL+S SD DSGANG
Sbjct: 358 -----------------------------------VKEDAQVGTVIALISVSDHDSGANG 382
Query: 426 QVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTV 485
QV C+L H F+L Y Y +V ++LDRER++ Y L + A D G+PPL +V
Sbjct: 383 QVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSV 442
Query: 486 RVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAG 545
V D NDNAP F + Y V V+ENNPPG ++ TV+A D D N V+Y L+E +G
Sbjct: 443 EVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGER- 501
Query: 546 GAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDH 605
++S+YVSV +G +YAL+ D+E L L ++ A DGG P L S+ +QV VLD+ND+
Sbjct: 502 -SLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDN 560
Query: 606 AP-VLVHPA-PANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREA 661
AP +L PA A G++ V VVA+V+A DAD G N L++ELQ R
Sbjct: 561 APALLASPAGSAGGAVSELVLRSVVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIP 620
Query: 662 FAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAP 721
F +G TGEI T L + R R L+++ D G P LT TATV V G + P A
Sbjct: 621 FRVGLYTGEISTTRALDETDSPRQ-RLLVLVKDHGEPSLTATATV-LVSLVEGSQAPKAS 678
Query: 722 ASAGSPERSRPPGSRLGVSGSVLQWDTPL-IVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
+ A +GV+ V D + ++I + A S L+L ++ A C+ E
Sbjct: 679 SRAS-----------VGVAPEVALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAAPTE 727
>gi|9256574 protocadherin alpha 10 isoform 1 precursor [Homo
sapiens]
Length = 948
Score = 421 bits (1083), Expect = e-117
Identities = 275/780 (35%), Positives = 416/780 (53%), Gaps = 68/780 (8%)
Query: 8 GSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRL 65
G CL L W + Q + YS +EE GT +G +A+DL ++++ FR+
Sbjct: 9 GVQCLLLSLLLLAAWEVGSGQ---LHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRV 65
Query: 66 MKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEV 125
+ + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ HV+VEV
Sbjct: 66 ASKRHGDLLEVNLQNGILFV-NSRIDREELCGRSVECSIHLEVIV--DRPLQVFHVDVEV 122
Query: 126 RDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVEL 185
+D+ND+ PRF + + + E + +R PLE D DVG N L T +L+ P+ F +++
Sbjct: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLS-PNEYFVLDI 181
Query: 186 QTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAF 245
+ D + LVL + LDRE L L A DGG+P + + +L + VLDAND++P F
Sbjct: 182 INKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIF 241
Query: 246 PQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGR 305
+ V EV++ E+ +L++ L+A+D DEG N +++++F + PP RR F ++ R+G
Sbjct: 242 DR-PVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE 300
Query: 306 LTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAP 365
+ + +D+E +TYE+ V D+G P C V+V + D NDN+P++ +T L+ P
Sbjct: 301 IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLP--- 357
Query: 366 ATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANG 425
V E A +++AL+S SD DSGANG
Sbjct: 358 -----------------------------------VKEDAQVGTVIALISVSDHDSGANG 382
Query: 426 QVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTV 485
QV C+L H F+L Y Y +V ++LDRER++ Y L + A D G+PPL +V
Sbjct: 383 QVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSV 442
Query: 486 RVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAG 545
V D NDNAP F + Y V V+ENNPPG ++ TV+A D D N V+Y L+E +G
Sbjct: 443 EVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGER- 501
Query: 546 GAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDH 605
++S+YVSV +G +YAL+ D+E L L ++ A DGG P L S+ +QV VLD+ND+
Sbjct: 502 -SLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDN 560
Query: 606 AP-VLVHPA-PANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREA 661
AP +L PA A G++ V VVA+V+A DAD G N L++ELQ R
Sbjct: 561 APALLASPAGSAGGAVSELVLRSVVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIP 620
Query: 662 FAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAP 721
F +G TGEI T L + R R L+++ D G P LT TATV V G + P A
Sbjct: 621 FRVGLYTGEISTTRALDETDSPRQ-RLLVLVKDHGEPSLTATATV-LVSLVEGSQAPKAS 678
Query: 722 ASAGSPERSRPPGSRLGVSGSVLQWDTPL-IVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
+ A +GV+ V D + ++I + A S L+L ++ A C+ E
Sbjct: 679 SRAS-----------VGVAPEVALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAAPTE 727
>gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo
sapiens]
Length = 803
Score = 420 bits (1080), Expect = e-117
Identities = 274/780 (35%), Positives = 411/780 (52%), Gaps = 65/780 (8%)
Query: 2 SPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG-- 59
+P R G CL L W + Q + YS EE GT +G +A+DL ++++
Sbjct: 4 TPEDRLGKQCLLLPLLLLAAWKVGSGQ---LHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
Query: 60 DTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLV 119
FR+ + LL V +G L V ++ +DRE LCG++ +C + +V+ ++
Sbjct: 61 PRLFRMASKDREDLLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVF 117
Query: 120 HVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHS 179
HV+VEVRD+ND+ P FP + V + E + PLE D DVG+N + T +L+
Sbjct: 118 HVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEY 177
Query: 180 PFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAN 239
F ++++ +D + L+L + LDRE A++L L A DGG+P + T L V VLD N
Sbjct: 178 -FGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVN 236
Query: 240 DHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRL 299
D++P F Q EV + E+A G+ ++ L+A+D DEG NG + ++F + F +
Sbjct: 237 DNAPTFEQSEY-EVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSI 295
Query: 300 DPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPL 359
D +G + + G +D+E+++ Y++ + A D+G P A C V+VRI D NDN P+IA+T L
Sbjct: 296 DRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSL 355
Query: 360 AAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDR 419
+ P V E A +++AL+S +D
Sbjct: 356 SLP--------------------------------------VREDAQFGTVIALISVNDL 377
Query: 420 DSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRT 479
DSGANGQV C+L H F+L + Y +V ++LDRE ++ Y L + A D G+P L
Sbjct: 378 DSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWA 437
Query: 480 VRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEA 539
+V V D NDNAP F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E
Sbjct: 438 TASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVER 497
Query: 540 EVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRV 599
VG A+S+Y+SV +G +YAL+ D+E L L ++ A D G P L S+ +QV V
Sbjct: 498 RVGER--ALSSYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFV 555
Query: 600 LDQNDHAPVLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQ--Q 655
LD+ND+AP L+ P G++ VP VVA+V+A DAD G N L++ELQ
Sbjct: 556 LDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPA 615
Query: 656 QEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGG 715
R F +G TGEI T L + R R L+++ D G P LT TATV V G
Sbjct: 616 SSARFPFRVGLYTGEISTTRVLDEADSPR-HRLLVLVKDHGEPALTATATV-LVSLVESG 673
Query: 716 RGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
+ P A +S S + P + + V+ ++I + A S L+L ++ A C+
Sbjct: 674 QAPKA-SSRASVGAAGPEAALVDVN--------VYLIIAICAVSSLLVLTLLLYTALRCS 724
>gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens]
Length = 950
Score = 420 bits (1080), Expect = e-117
Identities = 274/780 (35%), Positives = 411/780 (52%), Gaps = 65/780 (8%)
Query: 2 SPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG-- 59
+P R G CL L W + Q + YS EE GT +G +A+DL ++++
Sbjct: 4 TPEDRLGKQCLLLPLLLLAAWKVGSGQ---LHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
Query: 60 DTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLV 119
FR+ + LL V +G L V ++ +DRE LCG++ +C + +V+ ++
Sbjct: 61 PRLFRMASKDREDLLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVF 117
Query: 120 HVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHS 179
HV+VEVRD+ND+ P FP + V + E + PLE D DVG+N + T +L+
Sbjct: 118 HVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEY 177
Query: 180 PFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAN 239
F ++++ +D + L+L + LDRE A++L L A DGG+P + T L V VLD N
Sbjct: 178 -FGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVN 236
Query: 240 DHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRL 299
D++P F Q EV + E+A G+ ++ L+A+D DEG NG + ++F + F +
Sbjct: 237 DNAPTFEQSEY-EVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSI 295
Query: 300 DPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPL 359
D +G + + G +D+E+++ Y++ + A D+G P A C V+VRI D NDN P+IA+T L
Sbjct: 296 DRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSL 355
Query: 360 AAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDR 419
+ P V E A +++AL+S +D
Sbjct: 356 SLP--------------------------------------VREDAQFGTVIALISVNDL 377
Query: 420 DSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRT 479
DSGANGQV C+L H F+L + Y +V ++LDRE ++ Y L + A D G+P L
Sbjct: 378 DSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWA 437
Query: 480 VRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEA 539
+V V D NDNAP F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E
Sbjct: 438 TASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVER 497
Query: 540 EVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRV 599
VG A+S+Y+SV +G +YAL+ D+E L L ++ A D G P L S+ +QV V
Sbjct: 498 RVGER--ALSSYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFV 555
Query: 600 LDQNDHAPVLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQ--Q 655
LD+ND+AP L+ P G++ VP VVA+V+A DAD G N L++ELQ
Sbjct: 556 LDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPA 615
Query: 656 QEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGG 715
R F +G TGEI T L + R R L+++ D G P LT TATV V G
Sbjct: 616 SSARFPFRVGLYTGEISTTRVLDEADSPR-HRLLVLVKDHGEPALTATATV-LVSLVESG 673
Query: 716 RGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
+ P A +S S + P + + V+ ++I + A S L+L ++ A C+
Sbjct: 674 QAPKA-SSRASVGAAGPEAALVDVN--------VYLIIAICAVSSLLVLTLLLYTALRCS 724
>gi|14196468 protocadherin gamma subfamily A, 4 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 420 bits (1080), Expect = e-117
Identities = 275/774 (35%), Positives = 413/774 (53%), Gaps = 75/774 (9%)
Query: 15 LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHM--KVSGDTSFRLMKQFNSS 72
LQ+ L VL +++ + YS FEE G+V+G +A+DL + + + R++ + +
Sbjct: 14 LQICLLLGVLVEIRAEQILYSVFEEQEEGSVVGNIAKDLGLAPRELAERGVRIVSRGRTQ 73
Query: 73 LLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHA 132
L + G L +DRE LC ++P CV +++ ++ +++ VEVE+ DVND+
Sbjct: 74 LFALNPRSGTLVTAGR-IDREELCDRSPNCVTNLEILL--EDTVKILRVEVEIIDVNDNP 130
Query: 133 PRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGA 192
P F Q ++V+E G R PL D DVG N LQ +L + F +++Q+ ADG
Sbjct: 131 PSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQL-NSNGYFSLDVQSGADGI 189
Query: 193 QCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAE 252
+ +LVL + LDRE +A + L L A DGG P RS TA + + ++D ND++P F Q
Sbjct: 190 KYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEY-H 248
Query: 253 VELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPV 312
V + E+ PVG+ LL + A DPDEG NGDV ++F + + +LF+L+ SG +T+ G +
Sbjct: 249 VSVRENVPVGTRLLTVKATDPDEGANGDVTYSF-RKVRDKISQLFQLNSLSGDITILGGL 307
Query: 313 DYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAA 372
DYE Y++DV A D GPG RA + KV+V + D NDNAP++ +T L
Sbjct: 308 DYEDSGFYDIDVEAHD-GPGLRARS-KVLVTVLDENDNAPEVTVTSL------------- 352
Query: 373 AAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALY 432
TS V E ++ +++AL + D DSG NG V C++
Sbjct: 353 -------------------------TSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSIP 387
Query: 433 GHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDEND 492
+ F L+ Y Y ++T +LDRE ++EYN+T+ A D+G PPL T +++V D ND
Sbjct: 388 DNLPFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDIND 447
Query: 493 NAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYV 552
N P F Y + ENNP GA + ++ A+D D G N ++TY L AE G +S+YV
Sbjct: 448 NPPTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSL--AEDTFQGAPLSSYV 505
Query: 553 SVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP 612
S++ TG +YAL SFDYE R L + + ASD G P LSS+ + + VLDQND+ P +++P
Sbjct: 506 SINSNTGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYP 565
Query: 613 A-PANGSLEVAVPGRTA-KDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGE 670
P +GS V + R+A +V +V A D D G N L++ L + FA+G TGE
Sbjct: 566 TFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGE 625
Query: 671 I-----LLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAG 725
+ LL D ++ R ++V+ D G+PPL+ T T++ V P A G
Sbjct: 626 VRTARALLDRDALKQ------RLVVVVQDHGQPPLSATVTLTVAV---ADSIPDVLADLG 676
Query: 726 SPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKK 779
S + S P SG L +V+ V A SC L + +A R K
Sbjct: 677 SLKPSADPDD----SGLTL-----YLVVAVAAVSCVFLAFVTVLLALKLRRWHK 721
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,364,869
Number of Sequences: 37866
Number of extensions: 2207499
Number of successful extensions: 19210
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 215
Number of HSP's successfully gapped in prelim test: 105
Number of HSP's that attempted gapping in prelim test: 10597
Number of HSP's gapped (non-prelim): 2491
length of query: 973
length of database: 18,247,518
effective HSP length: 112
effective length of query: 861
effective length of database: 14,006,526
effective search space: 12059618886
effective search space used: 12059618886
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.