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Search of human proteins with 142976675
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]
(713 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens] 1453 0.0
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 1127 0.0
gi|51242945 striatin, calmodulin binding protein [Homo sapiens] 821 0.0
gi|89886480 zinedin isoform 2 [Homo sapiens] 752 0.0
gi|89886477 zinedin isoform 1 [Homo sapiens] 751 0.0
gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens] 108 2e-23
gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens] 108 2e-23
gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens] 107 4e-23
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 94 3e-19
gi|32189425 WD repeat domain 69 [Homo sapiens] 94 6e-19
gi|26665869 WD repeat domain 51B [Homo sapiens] 91 3e-18
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 87 4e-17
gi|23199987 WD repeat domain 5B [Homo sapiens] 86 2e-16
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 82 2e-15
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 82 2e-15
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 82 2e-15
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 82 2e-15
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 82 2e-15
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 82 2e-15
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 82 2e-15
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 81 3e-15
gi|16554629 WD repeat domain 5 [Homo sapiens] 80 7e-15
gi|16554627 WD repeat domain 5 [Homo sapiens] 80 7e-15
gi|19913367 transducin beta-like 1Y [Homo sapiens] 79 2e-14
gi|19913365 transducin beta-like 1Y [Homo sapiens] 79 2e-14
gi|15150805 transducin beta-like 1Y [Homo sapiens] 79 2e-14
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 77 4e-14
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 77 4e-14
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 77 4e-14
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 77 7e-14
>gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]
Length = 713
Score = 1453 bits (3762), Expect = 0.0
Identities = 713/713 (100%), Positives = 713/713 (100%)
Query: 1 MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRP 60
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRP
Sbjct: 1 MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRP 60
Query: 61 QQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKM 120
QQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKM
Sbjct: 61 QQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKM 120
Query: 121 LEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLR 180
LEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLR
Sbjct: 121 LEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLR 180
Query: 181 QYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRS 240
QYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRS
Sbjct: 181 QYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRS 240
Query: 241 SGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEE 300
SGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEE
Sbjct: 241 SGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEE 300
Query: 301 ALKEFDFLVTAEDGEGAGEARSSGDGTEWAEPITFPSGGGKSFIMGSDDVLLSVLGLGDL 360
ALKEFDFLVTAEDGEGAGEARSSGDGTEWAEPITFPSGGGKSFIMGSDDVLLSVLGLGDL
Sbjct: 301 ALKEFDFLVTAEDGEGAGEARSSGDGTEWAEPITFPSGGGKSFIMGSDDVLLSVLGLGDL 360
Query: 361 ADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTL 420
ADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTL
Sbjct: 361 ADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTL 420
Query: 421 KLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPS 480
KLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPS
Sbjct: 421 KLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPS 480
Query: 481 PSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICT 540
PSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICT
Sbjct: 481 PSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICT 540
Query: 541 YNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHI 600
YNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHI
Sbjct: 541 YNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHI 600
Query: 601 NRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHD 660
NRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHD
Sbjct: 601 NRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHD 660
Query: 661 CSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 713
CSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV
Sbjct: 661 CSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 713
>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
Length = 797
Score = 1127 bits (2916), Expect = 0.0
Identities = 601/801 (75%), Positives = 619/801 (77%), Gaps = 92/801 (11%)
Query: 1 MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRP 60
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRP
Sbjct: 1 MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRP 60
Query: 61 QQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKM 120
QQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKM
Sbjct: 61 QQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKM 120
Query: 121 LEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLR 180
LEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLR
Sbjct: 121 LEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLR 180
Query: 181 QYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRS 240
QYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRS
Sbjct: 181 QYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRS 240
Query: 241 SGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEE 300
SGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEE
Sbjct: 241 SGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEE 300
Query: 301 ALKEFDFLVTAEDGEGAGEARSSGDGTEWAEPITFPSGGGKSFIMGSDDVLLSVL----- 355
ALKEFDFLVTAEDGEGAGEARSSGDGTEW + P+ + + D L+S L
Sbjct: 301 ALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLSPT----AEVWDVDQGLISKLKEQYK 356
Query: 356 ----GLGDLADLTVTNDADYSYD-----LPANKDAFRKTWNPKYTLRSHFDGVRALAFHP 406
G + T D D LP T + +G RA P
Sbjct: 357 KERKGKKGVKRANRTKLYDMIADLGDDELPHIPSGIINQSRSASTRMTDHEGARAEEAEP 416
Query: 407 VE------PVLVTASEDHTLKLWNL--------------QKTVPAKKSASLDV-EPIYTF 445
+ + S+D L + L +PA K A P YT
Sbjct: 417 ITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWNPKYTL 476
Query: 446 RAHIGPVLSLAISSNGEQCFSGGIDATIQWWN---------------------------- 477
R+H V +LA + D T++ WN
Sbjct: 477 RSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPV 536
Query: 478 -------------------------MPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSG 512
MPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSG
Sbjct: 537 LSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSG 596
Query: 513 IKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSA 572
IKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSA
Sbjct: 597 IKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSA 656
Query: 573 VIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMI 632
VIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMI
Sbjct: 657 VIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMI 716
Query: 633 HSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVA 692
HSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVA
Sbjct: 717 HSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVA 776
Query: 693 FHSSKAYIASAGADALAKVFV 713
FHSSKAYIASAGADALAKVFV
Sbjct: 777 FHSSKAYIASAGADALAKVFV 797
>gi|51242945 striatin, calmodulin binding protein [Homo sapiens]
Length = 780
Score = 821 bits (2121), Expect = 0.0
Identities = 440/780 (56%), Positives = 533/780 (68%), Gaps = 88/780 (11%)
Query: 20 QQQGPGGNLGLSPGGNGAAGGGGPPA-SEGAGPAAGPELSRPQQYTIPGILHYIQHEWAR 78
+Q GPG + G G A G GP A + AG A + QY++PGILH++QHEWAR
Sbjct: 3 EQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWAR 62
Query: 79 FEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG 138
FE+ERA WEVERAELQA+IAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG
Sbjct: 63 FEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG 122
Query: 139 TELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQ 198
TELNQGD+K P+++S+E +TE QNSQL WKQGRQLLRQYLQEVGYTDTILDV+S+
Sbjct: 123 TELNQGDMKPPSYDSDEGNETEVQPQ-QNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSK 181
Query: 199 RVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRS----SGDVLETFNFL--- 251
RVR+LLG S S+ + KN + ++NG E+ ++ I +S S VL+ F FL
Sbjct: 182 RVRALLGFS-SDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESA 240
Query: 252 ------ENADDS---------------------DEDEENDMIEGIPE------------- 271
E+ DD D E+ D E + E
Sbjct: 241 AADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNE 300
Query: 272 ------GKD-----------------------KHRMNKHKIGNEGLAA-DLTDDPDTEEA 301
G D K + K + G +G+ + + D
Sbjct: 301 SRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLAN 360
Query: 302 LKEFDFLVTAEDGEGAGEARSSG-------DGTEWAEPITFPSGGGKSFIMGSDDVLLSV 354
L++ D L + + G+ SS + + E +TFP GKSFIMG+D+ L S
Sbjct: 361 LRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESE 420
Query: 355 LGLGDLADLTVTNDAD-YSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVT 413
LGLG+LA LTV N+AD +YD+ NKDA RKTWNPK+TLRSHFDG+RALAFHP+EPVL+T
Sbjct: 421 LGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLIT 480
Query: 414 ASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATI 473
ASEDHTLK+WNLQKT PAKKS SLDVEPIYTFRAH GPVL + +SSNGEQC+SGG D I
Sbjct: 481 ASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLI 540
Query: 474 QWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQE 533
Q WN +P++DPYD+Y+P+VL G L+GHTDAVWGLAYS +LLSCSADGT+RLWN E
Sbjct: 541 QGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE 600
Query: 534 KLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSG 593
P + +N K+ GIP SVD + DP+HMV SF+ G I+++ET Q ++ L S VD+
Sbjct: 601 VAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTT 660
Query: 594 LQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIY 653
S+ INRV+SHPTLP++ITAHEDRHIKF+DN TGK+IHSMVAHL+AVTSLAVDPNG+Y
Sbjct: 661 ANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLY 720
Query: 654 LMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 713
LMSGSHDCSIRLWNL+SKTC+QE TAHRKK +ESI+DVAFH SK YIASAGADALAKVFV
Sbjct: 721 LMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV 780
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 752 bits (1941), Expect = 0.0
Identities = 418/769 (54%), Positives = 514/769 (66%), Gaps = 87/769 (11%)
Query: 4 LAGGGGGGPGMAAP-PRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQ 62
L G G GP AAP GPG P G G GGG P GP AGPE
Sbjct: 20 LGSGAGPGPTGAAPVSAPAPGPG------PAGKGGGGGGSP------GPTAGPE-----P 62
Query: 63 YTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLE 122
++PGILH+IQHEWARFE E+A WE ERAELQA++AFLQGERKGQENLK DLVRRIKMLE
Sbjct: 63 LSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLE 122
Query: 123 YALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQY 182
YALKQERAKYHKLK+GT+LNQG+ K E E+ T +NS L WK+GRQLLRQY
Sbjct: 123 YALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTL-ENSPLVWKEGRQLLRQY 181
Query: 183 LQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQI-------LNGGES--PKQK 233
L+EVGYTDTILD+RS+RVRSLLG S E NG+VE L+GGES KQ
Sbjct: 182 LEEVGYTDTILDMRSKRVRSLLGRS-LELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
Query: 234 GQEIKRSS----------GDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKI 283
++IKR++ G VL FL+N +D D DE++++ +H+ + K+
Sbjct: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDEL------DSVQHKKQRVKL 294
Query: 284 GNEGLAADLTDDP---DTEEALKEFDFLVTAEDGEGAGEARS-SGDGTEWA--------- 330
++ L ++ D+ D+E+A+ EFDFL + EDGEGA + R + DG+
Sbjct: 295 PSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQ 354
Query: 331 -------------EPITFPSGGGK-------SFIMGSDDVLLSVLG-----LGDLADLTV 365
+T P G SF SD ++ +G LGDLADLTV
Sbjct: 355 GILADLRDVDGLPPKVTGPPPGTPQPRPHEGSFGFSSDVFIMDTIGGGEVSLGDLADLTV 414
Query: 366 TNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL 425
TND D S DL +KDAF+KTWNPK+TLRSH+DG+R+LAFH + L+TASED TLKLWNL
Sbjct: 415 TNDNDLSCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNL 474
Query: 426 QKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDP 485
QK V AKK+A+LDVEPI+ FRAH GPVL++A+ SN E C+SGG DA I W +P S+DP
Sbjct: 475 QKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDP 534
Query: 486 YDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLP-CICTYNGD 544
YD Y+P+VL+ L GH DAVWGLA+S +L SCSADGTVR+W+P P C+CT+
Sbjct: 535 YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTA 594
Query: 545 KKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVV 604
+HG+PTSV F +PAH+V SF +G V+YD+E +L+ L S+ SG IN+VV
Sbjct: 595 SEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG---PTQINQVV 651
Query: 605 SHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIR 664
SHP P+TITAH+DR I+F DN+TGK +HSMVAHLDAVT LAVDPNG +LMSGSHDCS+R
Sbjct: 652 SHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLR 711
Query: 665 LWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 713
LW+LD+KTCVQEITAHRKK +E+I+ VA H SKA IASAGADALAKVFV
Sbjct: 712 LWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 760
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 751 bits (1938), Expect = 0.0
Identities = 415/762 (54%), Positives = 511/762 (67%), Gaps = 80/762 (10%)
Query: 4 LAGGGGGGPGMAAP-PRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQ 62
L G G GP AAP GPG P G G GGG P GP AGPE
Sbjct: 20 LGSGAGPGPTGAAPVSAPAPGPG------PAGKGGGGGGSP------GPTAGPE-----P 62
Query: 63 YTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLE 122
++PGILH+IQHEWARFE E+A WE ERAELQA++AFLQGERKGQENLK DLVRRIKMLE
Sbjct: 63 LSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLE 122
Query: 123 YALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQY 182
YALKQERAKYHKLK+GT+LNQG+ K E E+ T +NS L WK+GRQLLRQY
Sbjct: 123 YALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTL-ENSPLVWKEGRQLLRQY 181
Query: 183 LQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQI-------LNGGES--PKQK 233
L+EVGYTDTILD+RS+RVRSLLG S E NG+VE L+GGES KQ
Sbjct: 182 LEEVGYTDTILDMRSKRVRSLLGRS-LELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
Query: 234 GQEIKRSS----------GDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKI 283
++IKR++ G VL FL+N +D D DE++++ +H+ + K+
Sbjct: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDEL------DSVQHKKQRVKL 294
Query: 284 GNEGLAADLTDDP---DTEEALKEFDFLVTAEDGEGAGEARS-SGDGTEWA--------- 330
++ L ++ D+ D+E+A+ EFDFL + EDGEGA + R + DG+
Sbjct: 295 PSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQ 354
Query: 331 -------------EPITFPSGGGKSFIMGSDDVLLSVLG-----LGDLADLTVTNDADYS 372
+T P G D ++ +G LGDLADLTVTND D S
Sbjct: 355 GILADLRDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLS 414
Query: 373 YDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAK 432
DL +KDAF+KTWNPK+TLRSH+DG+R+LAFH + L+TASED TLKLWNLQK V AK
Sbjct: 415 CDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAK 474
Query: 433 KSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPN 492
K+A+LDVEPI+ FRAH GPVL++A+ SN E C+SGG DA I W +P S+DPYD Y+P+
Sbjct: 475 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 534
Query: 493 VLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLP-CICTYNGDKKHGIPT 551
VL+ L GH DAVWGLA+S +L SCSADGTVR+W+P P C+CT+ +HG+PT
Sbjct: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 594
Query: 552 SVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPV 611
SV F +PAH+V SF +G V+YD+E +L+ L S+ SG IN+VVSHP P+
Sbjct: 595 SVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG---PTQINQVVSHPNQPL 651
Query: 612 TITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSK 671
TITAH+DR I+F DN+TGK +HSMVAHLDAVT LAVDPNG +LMSGSHDCS+RLW+LD+K
Sbjct: 652 TITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 711
Query: 672 TCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 713
TCVQEITAHRKK +E+I+ VA H SKA IASAGADALAKVFV
Sbjct: 712 TCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 753
>gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens]
Length = 127
Score = 108 bits (269), Expect = 2e-23
Identities = 57/107 (53%), Positives = 71/107 (66%), Gaps = 9/107 (8%)
Query: 83 RAHWEVERAELQ---------ARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYH 133
++ WE + Q A+IAFLQGERK QENLKKDLVR+IKMLEYALKQ+RAKYH
Sbjct: 7 KSRWETGEVQAQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66
Query: 134 KLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLR 180
KLKYG ELNQGD+K P+++S+ T + S T + Q L+
Sbjct: 67 KLKYGRELNQGDMKPPSYDSDSTLTKQPVNVKTRSTTTQTKVVQFLQ 113
>gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens]
Length = 127
Score = 108 bits (269), Expect = 2e-23
Identities = 57/107 (53%), Positives = 71/107 (66%), Gaps = 9/107 (8%)
Query: 83 RAHWEVERAELQ---------ARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYH 133
++ WE + Q A+IAFLQGERK QENLKKDLVR+IKMLEYALKQ+RAKYH
Sbjct: 7 KSRWETGEVQAQSATKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66
Query: 134 KLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLR 180
KLKYG ELNQGD+K P+++S+ T + S T + Q L+
Sbjct: 67 KLKYGRELNQGDMKPPSYDSDSTLTKQPVNVKTRSTTTQTKVVQFLQ 113
>gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens]
Length = 127
Score = 107 bits (267), Expect = 4e-23
Identities = 57/107 (53%), Positives = 70/107 (65%), Gaps = 9/107 (8%)
Query: 83 RAHWEVERAELQ---------ARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYH 133
++ WE + Q A+IAFLQGERK QENLKKDLVR+IKMLEYALKQ+RAKYH
Sbjct: 7 KSRWETGEVQAQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66
Query: 134 KLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLR 180
KLKYG ELNQGD+K P ++S+ T + S T + Q L+
Sbjct: 67 KLKYGRELNQGDMKPPIYDSDSTLTKQPVNVKTRSTTTQTKVVQFLQ 113
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 94.4 bits (233), Expect = 3e-19
Identities = 80/356 (22%), Positives = 149/356 (41%), Gaps = 67/356 (18%)
Query: 384 KTWNP----KYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDV 439
K W P KY L H V + FHPV V+V+ASED T+K+W+ + + D
Sbjct: 92 KEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYE---------TGDF 142
Query: 440 EPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLV 499
E T + H V ++ +G+ S D TI+ W+ ++ T+
Sbjct: 143 E--RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWD-----------FQGFECIRTMH 189
Query: 500 GHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCD 559
GH V +A + ++S S D T+++W Q C+ T+ G ++
Sbjct: 190 GHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGY-CVKTFTGHREW------------ 236
Query: 560 PAHMVTSFNTGS--AVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTL-------- 609
MV G+ A + +T + V+ + + + L+ + H+ +S
Sbjct: 237 -VRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 610 -------------PVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMS 656
P ++ D+ IK +D TG + ++V H + V + G +++S
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILS 355
Query: 657 GSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
+ D ++R+W+ +K C++ + AH + + + FH + Y+ + D KV+
Sbjct: 356 CADDKTLRVWDYKNKRCMKTLNAH----EHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 76.3 bits (186), Expect = 9e-14
Identities = 77/316 (24%), Positives = 132/316 (41%), Gaps = 48/316 (15%)
Query: 371 YSYDLPANKDAFRKTWNPKY-----TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL 425
+S + A++DA K W+ + TL+ H D V+ ++F +L + S D T+KLW+
Sbjct: 120 FSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDF 179
Query: 426 QKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDP 485
Q E I T H V S+AI NG+ S D TI+ W +
Sbjct: 180 Q-----------GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV------- 221
Query: 486 YDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDK 545
+ T GH + V + + + SCS D TVR+W K C +
Sbjct: 222 ----QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATK-ECKAELR-EH 275
Query: 546 KHGIPTSVDFIGCDPAHMVTSFN---------TGSAVIYDLETSQSLVILSSQVDSGL-- 594
+H V+ I P +S + +G + L S+ I V +G+
Sbjct: 276 EH----VVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCL 331
Query: 595 ----QSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPN 650
+N + V+ H ++ +D+ ++ +D K + + ++ AH VTSL
Sbjct: 332 MTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKT 391
Query: 651 GIYLMSGSHDCSIRLW 666
Y+++GS D ++++W
Sbjct: 392 APYVVTGSVDQTVKVW 407
Score = 54.7 bits (130), Expect = 3e-07
Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 46/156 (29%)
Query: 600 INRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAV----------------- 642
+ RV+ HP V ++A ED IK +D +TG ++ H D+V
Sbjct: 111 VTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSA 170
Query: 643 -------------------------TSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEI 677
+S+A+ PNG +++S S D +I++W + + CV+
Sbjct: 171 DMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTF 230
Query: 678 TAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 713
T HR E + V + IAS D +V+V
Sbjct: 231 TGHR----EWVRMVRPNQDGTLIASCSNDQTVRVWV 262
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 93.6 bits (231), Expect = 6e-19
Identities = 63/277 (22%), Positives = 124/277 (44%), Gaps = 33/277 (11%)
Query: 390 YTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHI 449
+T R H + L+F+P ++ T S D T KLW++Q + E +YT R H
Sbjct: 171 HTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ-----------NGEEVYTLRGHS 219
Query: 450 GPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLA 509
++SL+ +++G++ +G D T+ W+ + L+GH + +
Sbjct: 220 AEIISLSFNTSGDRIITGSFDHTVVVWDA-----------DTGRKVNILIGHCAEISSAS 268
Query: 510 YSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNT 569
++ + +L+ S D T +LW+ C+ T G + + D+ G + T+
Sbjct: 269 FNWDCSLILTGSMDKTCKLWDATNG-KCVATLTGHDDEILDSCFDYTG---KLIATASAD 324
Query: 570 GSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTG 629
G+A I+ T + + L I+++ +P +T D+ + +D +TG
Sbjct: 325 GTARIFSAATRKCIAKLEGH-------EGEISKISFNPQGNHLLTGSSDKTARIWDAQTG 377
Query: 630 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLW 666
+ + + H D + S A + G +++GS D + R+W
Sbjct: 378 QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 78.6 bits (192), Expect = 2e-14
Identities = 70/306 (22%), Positives = 138/306 (45%), Gaps = 33/306 (10%)
Query: 411 LVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 470
L+TAS +KL + ++++ +AHI P+ ++A++ +G +G D
Sbjct: 54 LLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYD 113
Query: 471 ATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSG-IKNQLLSCSADGTVRLW 529
T + W+ S TL GH + V+ +A++ +++ + S D T +LW
Sbjct: 114 RTCKLWDTASGEE-----------LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162
Query: 530 NPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVIL--- 586
+ E C T+ G + S + T +A ++D++ + + L
Sbjct: 163 S-VETGKCYHTFRGHTAEIVCLS---FNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGH 218
Query: 587 SSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLA 646
S+++ S L N +R+ IT D + +D TG+ ++ ++ H ++S +
Sbjct: 219 SAEIIS-LSFNTSGDRI---------ITGSFDHTVVVWDADTGRKVNILIGHCAEISSAS 268
Query: 647 VDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGAD 706
+ + +++GS D + +LW+ + CV +T H D+ I D F + IA+A AD
Sbjct: 269 FNWDCSLILTGSMDKTCKLWDATNGKCVATLTGH----DDEILDSCFDYTGKLIATASAD 324
Query: 707 ALAKVF 712
A++F
Sbjct: 325 GTARIF 330
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 91.3 bits (225), Expect = 3e-18
Identities = 81/308 (26%), Positives = 128/308 (41%), Gaps = 48/308 (15%)
Query: 377 ANKDAFRKTWNPK-----YTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPA 431
A+ D F WN K Y H D V ++ F P +L +AS D T++LW +P
Sbjct: 36 ASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW-----IPD 90
Query: 432 KKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEP 491
K+ + F+AH PV S+ S++G+ + D +I+ W+M Y
Sbjct: 91 KRGKFSE------FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM----------YRQ 134
Query: 492 NVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPT 551
L +L HT V +S ++SCS D T+++W+ K C N G
Sbjct: 135 RFLY-SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQ---CVNNFSDSVGFAN 190
Query: 552 SVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQS----NNHINRVVSHP 607
VDF N I + Q++ + +V+ LQ + +N + HP
Sbjct: 191 FVDF------------NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHP 238
Query: 608 TLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLW- 666
+ ITA D +K D G++I+++ H V +++ G SG D + LW
Sbjct: 239 SGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298
Query: 667 -NLDSKTC 673
N D C
Sbjct: 299 TNFDELHC 306
Score = 80.5 bits (197), Expect = 5e-15
Identities = 65/280 (23%), Positives = 119/280 (42%), Gaps = 30/280 (10%)
Query: 435 ASLDVEPIYT--FRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPN 492
AS +P+ F+ H + SL +S NG+Q + D + WN ++P+
Sbjct: 2 ASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWN-----------FKPH 50
Query: 493 VLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPT- 551
A VGH D V + +S N L S S D TVRLW P ++ ++ K H P
Sbjct: 51 ARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKR----GKFSEFKAHTAPVR 106
Query: 552 SVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPV 611
SVDF D + T+ S ++ + + L L + + + P +
Sbjct: 107 SVDF-SADGQFLATASEDKSIKVWSMYRQRFLYSL-------YRHTHWVRCAKFSPDGRL 158
Query: 612 TITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSK 671
++ ED+ IK +D + +++ + + +P+G + S D ++++W++
Sbjct: 159 IVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN 218
Query: 672 TCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKV 711
+Q H + ++FH S Y+ +A +D K+
Sbjct: 219 KLLQHYQVH----SGGVNCISFHPSGNYLITASSDGTLKI 254
Score = 46.6 bits (109), Expect = 8e-05
Identities = 30/99 (30%), Positives = 45/99 (45%), Gaps = 4/99 (4%)
Query: 614 TAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTC 673
TA D + ++ K + V H D VTS+ P+G L S S D ++RLW D +
Sbjct: 35 TASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGK 94
Query: 674 VQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
E AH + V F + ++A+A D KV+
Sbjct: 95 FSEFKAH----TAPVRSVDFSADGQFLATASEDKSIKVW 129
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 87.4 bits (215), Expect = 4e-17
Identities = 84/337 (24%), Positives = 146/337 (43%), Gaps = 47/337 (13%)
Query: 386 WNPKYTL----RSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEP 441
W+P + L H VR +A P VT S D T+K+W+L K SL
Sbjct: 190 WHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL---ASGKLKLSL---- 242
Query: 442 IYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGH 501
HI V + +S+ FS G D ++ W++ E N + GH
Sbjct: 243 ----TGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL-----------EYNKVIRHYHGH 287
Query: 502 TDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPA 561
AV+GL + L++CS D T R+W+ + K + T +G +V + C A
Sbjct: 288 LSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTK-ASVHTLSGH-----TNAVATVRCQAA 341
Query: 562 --HMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDR 619
++T + + ++DL ++ V L++ S + VV HP T +
Sbjct: 342 EPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS-------VRAVVLHPR-HYTFASGSPD 393
Query: 620 HIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITA 679
+IK + G I ++ H + +L V+ +G+ L+SG+ + ++ LW+ + Q + A
Sbjct: 394 NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRTGYNFQRVHA 452
Query: 680 HRK----KLDESIYDVAFHSSKAYIASAGADALAKVF 712
+ + I+ AF S++ + +A AD KV+
Sbjct: 453 AVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
Score = 58.5 bits (140), Expect = 2e-08
Identities = 54/233 (23%), Positives = 95/233 (40%), Gaps = 28/233 (12%)
Query: 478 MPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWN-PQEKLP 536
MP P P P L + GH V +A ++ SAD T+++W+ KL
Sbjct: 185 MPKPQWHP-----PWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLK 239
Query: 537 CICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQS 596
T + G+ + ++ + +DLE ++ +
Sbjct: 240 LSLTGHISTVRGV-----IVSTRSPYLFSCGEDKQVKCWDLEYNKVI----------RHY 284
Query: 597 NNHINRVVS---HPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIY 653
+ H++ V HPT+ V +T D + +D +T +H++ H +AV ++
Sbjct: 285 HGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQ 344
Query: 654 LMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGAD 706
+++GSHD +IRLW+L + +T H+K S+ V H AS D
Sbjct: 345 IITGSHDTTIRLWDLVAGKTRVTLTNHKK----SVRAVVLHPRHYTFASGSPD 393
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 85.5 bits (210), Expect = 2e-16
Identities = 83/349 (23%), Positives = 149/349 (42%), Gaps = 44/349 (12%)
Query: 361 ADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTL 420
A L +++ A+ S ++P N + + K TL H + V ++ F P L ++S D +
Sbjct: 11 AQLALSSSANQSKEVPENPN-----YALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLI 65
Query: 421 KLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPS 480
+W + D + T H + +A SS+ + S D T++ W++ S
Sbjct: 66 IIWG-----------AYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRS 114
Query: 481 PSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICT 540
TL GH++ V+ ++ N ++S S D TV++W + C+ T
Sbjct: 115 GKC-----------LKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG-KCLKT 162
Query: 541 YNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHI 600
+ H P S C + +V+ G I+D + Q L L VD N +
Sbjct: 163 LSA---HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL---VDD---DNPPV 213
Query: 601 NRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVD---PNGIYLMSG 657
+ V P +TA D +K +D G+ + + H + + + G +++SG
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 273
Query: 658 SHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGAD 706
S D + +WNL +K VQ++ H + + A H ++ IASA +
Sbjct: 274 SEDNLVYIWNLQTKEIVQKLQGH----TDVVISAACHPTENLIASAALE 318
Score = 67.0 bits (162), Expect = 6e-11
Identities = 55/223 (24%), Positives = 104/223 (46%), Gaps = 15/223 (6%)
Query: 491 PN-VLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGI 549
PN L TLVGHT+AV + +S L S SAD + +W + Y H +
Sbjct: 29 PNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYG----HNL 84
Query: 550 PTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTL 609
S D + +V++ + + ++D+ + + L L +N++ +P
Sbjct: 85 EISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGH-------SNYVFCCNFNPPS 137
Query: 610 PVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLD 669
+ I+ D +K ++ KTGK + ++ AH D V+++ + +G ++SGS+D R+W+
Sbjct: 138 NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197
Query: 670 SKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
S C++ + + + V F + YI +A D K++
Sbjct: 198 SGQCLKTLVDDD---NPPVSFVKFSPNGKYILTATLDNTLKLW 237
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 82.0 bits (201), Expect = 2e-15
Identities = 81/344 (23%), Positives = 135/344 (39%), Gaps = 52/344 (15%)
Query: 387 NPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFR 446
N LR H V A++PV +L + S D T ++WNL ++ S S + +
Sbjct: 160 NKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNL-----SENSTSGSTQLVLRHC 214
Query: 447 AHIG--------PVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTL 498
G V SL +S G +G D + W T + N LA TL
Sbjct: 215 IREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIW-----------TKDGN-LASTL 262
Query: 499 VGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIP-TSVDFIG 557
H ++ L ++ N +LS D T +W+ + G+ K P S +
Sbjct: 263 GQHKGPIFALKWNKKGNFILSAGVDKTTIIWD---------AHTGEAKQQFPFHSAPALD 313
Query: 558 CDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHE 617
D S NT ++ D+ + + + N +N + PT + + +
Sbjct: 314 VD----WQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSD 369
Query: 618 DRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNG---------IYLMSGSHDCSIRLWNL 668
D +K + K +H + AH + ++ P G + L S S D ++RLW++
Sbjct: 370 DMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDV 429
Query: 669 DSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
D C+ +T H+ E +Y VAF Y+AS D ++
Sbjct: 430 DRGICIHTLTKHQ----EPVYSVAFSPDGRYLASGSFDKCVHIW 469
Score = 42.4 bits (98), Expect = 0.002
Identities = 55/255 (21%), Positives = 87/255 (34%), Gaps = 71/255 (27%)
Query: 487 DTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPC--------I 538
D P A L GH V+ A++ + + L S S D T R+WN E
Sbjct: 154 DVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRH 213
Query: 539 CTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGS--------------------------- 571
C G + +P++ D D T TGS
Sbjct: 214 CIREGGQ--DVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFA 271
Query: 572 ------------------AVIYDLETSQSLVIL----SSQVDSGLQSNNHINRVVSHPTL 609
+I+D T ++ + +D QSNN + +
Sbjct: 272 LKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCI 331
Query: 610 PVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLD 669
V +DR IK F H + V ++ DP G L S S D ++++W++
Sbjct: 332 HV-CKLGQDRPIKTFQ-----------GHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMK 379
Query: 670 SKTCVQEITAHRKKL 684
CV ++ AH K++
Sbjct: 380 QDNCVHDLQAHNKEI 394
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 81.6 bits (200), Expect = 2e-15
Identities = 80/338 (23%), Positives = 130/338 (38%), Gaps = 50/338 (14%)
Query: 392 LRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGP 451
LR H V A++PV +L + S D T ++WNL + S L + H P
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNG-GSTQLVLRHCIREGGHDVP 235
Query: 452 ----VLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWG 507
V SL ++NG +G D + W E LA TL H ++
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIWT------------EDGNLASTLGQHKGPIFA 283
Query: 508 LAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSF 567
L ++ N +LS D T +W+ + G+ K P F +
Sbjct: 284 LKWNRKGNYILSAGVDKTTIIWD---------AHTGEAKQQFP----FHSAPALDVDWQN 330
Query: 568 NTGSAVIYDLETSQSLVILSSQVDSGLQS----NNHINRVVSHPTLPVTITAHEDRHIKF 623
NT A T + + D +++ N +N + P+ + + +D +K
Sbjct: 331 NTTFA---SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 387
Query: 624 FDNKTGKMIHSMVAHLDAVTSLAVDPNG---------IYLMSGSHDCSIRLWNLDSKTCV 674
+ K IH + AH + ++ P G I L S S D ++RLW+++ C
Sbjct: 388 WSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT 447
Query: 675 QEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
+T H+ E +Y VAF Y+AS D ++
Sbjct: 448 HTLTKHQ----EPVYSVAFSPDGKYLASGSFDKCVHIW 481
Score = 47.4 bits (111), Expect = 5e-05
Identities = 63/286 (22%), Positives = 107/286 (37%), Gaps = 59/286 (20%)
Query: 447 AHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVW 506
+H P + + NGE+ + ++ N P + P+ A L GH V+
Sbjct: 132 SHQNPSKNREATVNGEENRAHSVN------NHAKPMEIDGEVEIPSSKATVLRGHESEVF 185
Query: 507 GLAYSGIKNQLLSCSADGTVRLWNPQEK--------LPCICTYNGDKKHGIPTSVDFIGC 558
A++ + + L S S D T R+WN E + C G H +P++ D
Sbjct: 186 ICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG--HDVPSNKDVTSL 243
Query: 559 DPAHMVTSFNTGSAVIYD----LETSQSLVILSSQVDSG----LQSNNHINRVVSHPTLP 610
D T TGS YD + T + + G L+ N N ++S
Sbjct: 244 DWNTNGTLLATGS---YDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 300
Query: 611 VTI--TAHE-------------------DRHIKFFDNKTGKMIH-----------SMVAH 638
TI AH + F T IH + H
Sbjct: 301 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 360
Query: 639 LDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKL 684
+ V ++ DP+G+ L S S D ++++W++ + C+ ++ AH K++
Sbjct: 361 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEI 406
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 81.6 bits (200), Expect = 2e-15
Identities = 80/338 (23%), Positives = 130/338 (38%), Gaps = 50/338 (14%)
Query: 392 LRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGP 451
LR H V A++PV +L + S D T ++WNL + S L + H P
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNG-GSTQLVLRHCIREGGHDVP 235
Query: 452 ----VLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWG 507
V SL ++NG +G D + W E LA TL H ++
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIWT------------EDGNLASTLGQHKGPIFA 283
Query: 508 LAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSF 567
L ++ N +LS D T +W+ + G+ K P F +
Sbjct: 284 LKWNRKGNYILSAGVDKTTIIWD---------AHTGEAKQQFP----FHSAPALDVDWQN 330
Query: 568 NTGSAVIYDLETSQSLVILSSQVDSGLQS----NNHINRVVSHPTLPVTITAHEDRHIKF 623
NT A T + + D +++ N +N + P+ + + +D +K
Sbjct: 331 NTTFA---SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 387
Query: 624 FDNKTGKMIHSMVAHLDAVTSLAVDPNG---------IYLMSGSHDCSIRLWNLDSKTCV 674
+ K IH + AH + ++ P G I L S S D ++RLW+++ C
Sbjct: 388 WSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT 447
Query: 675 QEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
+T H+ E +Y VAF Y+AS D ++
Sbjct: 448 HTLTKHQ----EPVYSVAFSPDGKYLASGSFDKCVHIW 481
Score = 47.4 bits (111), Expect = 5e-05
Identities = 63/286 (22%), Positives = 107/286 (37%), Gaps = 59/286 (20%)
Query: 447 AHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVW 506
+H P + + NGE+ + ++ N P + P+ A L GH V+
Sbjct: 132 SHQNPSKNREATVNGEENRAHSVN------NHAKPMEIDGEVEIPSSKATVLRGHESEVF 185
Query: 507 GLAYSGIKNQLLSCSADGTVRLWNPQEK--------LPCICTYNGDKKHGIPTSVDFIGC 558
A++ + + L S S D T R+WN E + C G H +P++ D
Sbjct: 186 ICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG--HDVPSNKDVTSL 243
Query: 559 DPAHMVTSFNTGSAVIYD----LETSQSLVILSSQVDSG----LQSNNHINRVVSHPTLP 610
D T TGS YD + T + + G L+ N N ++S
Sbjct: 244 DWNTNGTLLATGS---YDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 300
Query: 611 VTI--TAHE-------------------DRHIKFFDNKTGKMIH-----------SMVAH 638
TI AH + F T IH + H
Sbjct: 301 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 360
Query: 639 LDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKL 684
+ V ++ DP+G+ L S S D ++++W++ + C+ ++ AH K++
Sbjct: 361 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEI 406
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 81.6 bits (200), Expect = 2e-15
Identities = 80/338 (23%), Positives = 130/338 (38%), Gaps = 50/338 (14%)
Query: 392 LRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGP 451
LR H V A++PV +L + S D T ++WNL + S L + H P
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNG-GSTQLVLRHCIREGGHDVP 286
Query: 452 ----VLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWG 507
V SL ++NG +G D + W E LA TL H ++
Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIWT------------EDGNLASTLGQHKGPIFA 334
Query: 508 LAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSF 567
L ++ N +LS D T +W+ + G+ K P F +
Sbjct: 335 LKWNRKGNYILSAGVDKTTIIWD---------AHTGEAKQQFP----FHSAPALDVDWQN 381
Query: 568 NTGSAVIYDLETSQSLVILSSQVDSGLQS----NNHINRVVSHPTLPVTITAHEDRHIKF 623
NT A T + + D +++ N +N + P+ + + +D +K
Sbjct: 382 NTTFA---SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 438
Query: 624 FDNKTGKMIHSMVAHLDAVTSLAVDPNG---------IYLMSGSHDCSIRLWNLDSKTCV 674
+ K IH + AH + ++ P G I L S S D ++RLW+++ C
Sbjct: 439 WSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT 498
Query: 675 QEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
+T H+ E +Y VAF Y+AS D ++
Sbjct: 499 HTLTKHQ----EPVYSVAFSPDGKYLASGSFDKCVHIW 532
Score = 47.4 bits (111), Expect = 5e-05
Identities = 63/286 (22%), Positives = 107/286 (37%), Gaps = 59/286 (20%)
Query: 447 AHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVW 506
+H P + + NGE+ + ++ N P + P+ A L GH V+
Sbjct: 183 SHQNPSKNREATVNGEENRAHSVN------NHAKPMEIDGEVEIPSSKATVLRGHESEVF 236
Query: 507 GLAYSGIKNQLLSCSADGTVRLWNPQEK--------LPCICTYNGDKKHGIPTSVDFIGC 558
A++ + + L S S D T R+WN E + C G H +P++ D
Sbjct: 237 ICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG--HDVPSNKDVTSL 294
Query: 559 DPAHMVTSFNTGSAVIYD----LETSQSLVILSSQVDSG----LQSNNHINRVVSHPTLP 610
D T TGS YD + T + + G L+ N N ++S
Sbjct: 295 DWNTNGTLLATGS---YDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
Query: 611 VTI--TAHE-------------------DRHIKFFDNKTGKMIH-----------SMVAH 638
TI AH + F T IH + H
Sbjct: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
Query: 639 LDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKL 684
+ V ++ DP+G+ L S S D ++++W++ + C+ ++ AH K++
Sbjct: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEI 457
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 81.6 bits (200), Expect = 2e-15
Identities = 80/338 (23%), Positives = 130/338 (38%), Gaps = 50/338 (14%)
Query: 392 LRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGP 451
LR H V A++PV +L + S D T ++WNL + S L + H P
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNG-GSTQLVLRHCIREGGHDVP 286
Query: 452 ----VLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWG 507
V SL ++NG +G D + W E LA TL H ++
Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIWT------------EDGNLASTLGQHKGPIFA 334
Query: 508 LAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSF 567
L ++ N +LS D T +W+ + G+ K P F +
Sbjct: 335 LKWNRKGNYILSAGVDKTTIIWD---------AHTGEAKQQFP----FHSAPALDVDWQN 381
Query: 568 NTGSAVIYDLETSQSLVILSSQVDSGLQS----NNHINRVVSHPTLPVTITAHEDRHIKF 623
NT A T + + D +++ N +N + P+ + + +D +K
Sbjct: 382 NTTFA---SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 438
Query: 624 FDNKTGKMIHSMVAHLDAVTSLAVDPNG---------IYLMSGSHDCSIRLWNLDSKTCV 674
+ K IH + AH + ++ P G I L S S D ++RLW+++ C
Sbjct: 439 WSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT 498
Query: 675 QEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
+T H+ E +Y VAF Y+AS D ++
Sbjct: 499 HTLTKHQ----EPVYSVAFSPDGKYLASGSFDKCVHIW 532
Score = 47.4 bits (111), Expect = 5e-05
Identities = 63/286 (22%), Positives = 107/286 (37%), Gaps = 59/286 (20%)
Query: 447 AHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVW 506
+H P + + NGE+ + ++ N P + P+ A L GH V+
Sbjct: 183 SHQNPSKNREATVNGEENRAHSVN------NHAKPMEIDGEVEIPSSKATVLRGHESEVF 236
Query: 507 GLAYSGIKNQLLSCSADGTVRLWNPQEK--------LPCICTYNGDKKHGIPTSVDFIGC 558
A++ + + L S S D T R+WN E + C G H +P++ D
Sbjct: 237 ICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG--HDVPSNKDVTSL 294
Query: 559 DPAHMVTSFNTGSAVIYD----LETSQSLVILSSQVDSG----LQSNNHINRVVSHPTLP 610
D T TGS YD + T + + G L+ N N ++S
Sbjct: 295 DWNTNGTLLATGS---YDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
Query: 611 VTI--TAHE-------------------DRHIKFFDNKTGKMIH-----------SMVAH 638
TI AH + F T IH + H
Sbjct: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
Query: 639 LDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKL 684
+ V ++ DP+G+ L S S D ++++W++ + C+ ++ AH K++
Sbjct: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEI 457
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 81.6 bits (200), Expect = 2e-15
Identities = 70/305 (22%), Positives = 122/305 (40%), Gaps = 59/305 (19%)
Query: 399 VRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAIS 458
V+ L+FHP P ++T+ + ++LW+ + K F H GPV +
Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60
Query: 459 SNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLL 518
SGG D I+ WN Y+ TL+GH D + + +L
Sbjct: 61 KQQPLFVSGGDDYKIKVWN-----------YKLRRCLFTLLGHLDYIRTTFFHHEYPWIL 109
Query: 519 SCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAH----MVTSFNTGSAV- 573
S S D T+R+WN Q + C+C G ++ C H +V S + V
Sbjct: 110 SASDDQTIRVWNWQSR-TCVCVLTGHN--------HYVMCAQFHPTEDLVVSASLDQTVR 160
Query: 574 IYDLETSQSLVILSSQVDSGLQS---------------------NNHINRVVSHPTLPVT 612
++D+ + + V+S ++ + +N HPT+P+
Sbjct: 161 VWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLI 220
Query: 613 ITAHEDRHIKFFDNKTGKM--IHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDS 670
++ +DR +K + K + + H + V+ P ++S S D SIR+W++
Sbjct: 221 VSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSK 280
Query: 671 KTCVQ 675
+T VQ
Sbjct: 281 RTGVQ 285
Score = 56.6 bits (135), Expect = 8e-08
Identities = 33/150 (22%), Positives = 72/150 (48%), Gaps = 11/150 (7%)
Query: 563 MVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIK 622
++TS + G ++D + + +D + + + + H P+ ++ +D IK
Sbjct: 24 ILTSLHNGVIQLWDYR-------MCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIK 76
Query: 623 FFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRK 682
++ K + + +++ HLD + + +++S S D +IR+WN S+TCV +T H
Sbjct: 77 VWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGH-- 134
Query: 683 KLDESIYDVAFHSSKAYIASAGADALAKVF 712
+ + FH ++ + SA D +V+
Sbjct: 135 --NHYVMCAQFHPTEDLVVSASLDQTVRVW 162
Score = 48.9 bits (115), Expect = 2e-05
Identities = 66/324 (20%), Positives = 124/324 (38%), Gaps = 59/324 (18%)
Query: 384 KTWNPK-----YTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLD 438
K WN K +TL H D +R FH P +++AS+D T+++WN Q L
Sbjct: 76 KVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCV---CVLT 132
Query: 439 VEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTL 498
Y A P L +S++ +D T++ W++ + N+ G +
Sbjct: 133 GHNHYVMCAQFHPTEDLVVSAS--------LDQTVRVWDISG-------LRKKNLSPGAV 177
Query: 499 VGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGC 558
+ G+ G + ++ +G R V++
Sbjct: 178 ESDVRGITGVDLFGTTDAVVKHVLEGHDR------------------------GVNWAAF 213
Query: 559 DPAH--MVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAH 616
P +V+ + I+ + S++ +VD+ N+++ V HP + ++
Sbjct: 214 HPTMPLIVSGADDRQVKIWRMNESKAW-----EVDTCRGHYNNVSCAVFHPRQELILSNS 268
Query: 617 EDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKT---C 673
ED+ I+ +D + + D LA PN + L + HD + ++ L+ +
Sbjct: 269 EDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPN-LNLFAAGHDGGMIVFKLERERPAYA 327
Query: 674 VQEITAHRKKLDESIYDVAFHSSK 697
V H K D + + F+SSK
Sbjct: 328 VHGNMLHYVK-DRFLRQLDFNSSK 350
Score = 36.6 bits (83), Expect = 0.083
Identities = 25/107 (23%), Positives = 43/107 (40%), Gaps = 4/107 (3%)
Query: 606 HPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRL 665
HP P +T+ + I+ +D + +I H V + +SG D I++
Sbjct: 18 HPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKV 77
Query: 666 WNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
WN + C+ + H + I FH +I SA D +V+
Sbjct: 78 WNYKLRRCLFTLLGHL----DYIRTTFFHHEYPWILSASDDQTIRVW 120
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 81.6 bits (200), Expect = 2e-15
Identities = 70/305 (22%), Positives = 122/305 (40%), Gaps = 59/305 (19%)
Query: 399 VRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAIS 458
V+ L+FHP P ++T+ + ++LW+ + K F H GPV +
Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60
Query: 459 SNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLL 518
SGG D I+ WN Y+ TL+GH D + + +L
Sbjct: 61 KQQPLFVSGGDDYKIKVWN-----------YKLRRCLFTLLGHLDYIRTTFFHHEYPWIL 109
Query: 519 SCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAH----MVTSFNTGSAV- 573
S S D T+R+WN Q + C+C G ++ C H +V S + V
Sbjct: 110 SASDDQTIRVWNWQSR-TCVCVLTGHN--------HYVMCAQFHPTEDLVVSASLDQTVR 160
Query: 574 IYDLETSQSLVILSSQVDSGLQS---------------------NNHINRVVSHPTLPVT 612
++D+ + + V+S ++ + +N HPT+P+
Sbjct: 161 VWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLI 220
Query: 613 ITAHEDRHIKFFDNKTGKM--IHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDS 670
++ +DR +K + K + + H + V+ P ++S S D SIR+W++
Sbjct: 221 VSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSK 280
Query: 671 KTCVQ 675
+T VQ
Sbjct: 281 RTGVQ 285
Score = 56.6 bits (135), Expect = 8e-08
Identities = 33/150 (22%), Positives = 72/150 (48%), Gaps = 11/150 (7%)
Query: 563 MVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIK 622
++TS + G ++D + + +D + + + + H P+ ++ +D IK
Sbjct: 24 ILTSLHNGVIQLWDYR-------MCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIK 76
Query: 623 FFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRK 682
++ K + + +++ HLD + + +++S S D +IR+WN S+TCV +T H
Sbjct: 77 VWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGH-- 134
Query: 683 KLDESIYDVAFHSSKAYIASAGADALAKVF 712
+ + FH ++ + SA D +V+
Sbjct: 135 --NHYVMCAQFHPTEDLVVSASLDQTVRVW 162
Score = 48.9 bits (115), Expect = 2e-05
Identities = 66/324 (20%), Positives = 124/324 (38%), Gaps = 59/324 (18%)
Query: 384 KTWNPK-----YTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLD 438
K WN K +TL H D +R FH P +++AS+D T+++WN Q L
Sbjct: 76 KVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCV---CVLT 132
Query: 439 VEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTL 498
Y A P L +S++ +D T++ W++ + N+ G +
Sbjct: 133 GHNHYVMCAQFHPTEDLVVSAS--------LDQTVRVWDISG-------LRKKNLSPGAV 177
Query: 499 VGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGC 558
+ G+ G + ++ +G R V++
Sbjct: 178 ESDVRGITGVDLFGTTDAVVKHVLEGHDR------------------------GVNWAAF 213
Query: 559 DPAH--MVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAH 616
P +V+ + I+ + S++ +VD+ N+++ V HP + ++
Sbjct: 214 HPTMPLIVSGADDRQVKIWRMNESKAW-----EVDTCRGHYNNVSCAVFHPRQELILSNS 268
Query: 617 EDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKT---C 673
ED+ I+ +D + + D LA PN + L + HD + ++ L+ +
Sbjct: 269 EDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPN-LNLFAAGHDGGMIVFKLERERPAYA 327
Query: 674 VQEITAHRKKLDESIYDVAFHSSK 697
V H K D + + F+SSK
Sbjct: 328 VHGNMLHYVK-DRFLRQLDFNSSK 350
Score = 36.6 bits (83), Expect = 0.083
Identities = 25/107 (23%), Positives = 43/107 (40%), Gaps = 4/107 (3%)
Query: 606 HPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRL 665
HP P +T+ + I+ +D + +I H V + +SG D I++
Sbjct: 18 HPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKV 77
Query: 666 WNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
WN + C+ + H + I FH +I SA D +V+
Sbjct: 78 WNYKLRRCLFTLLGHL----DYIRTTFFHHEYPWILSASDDQTIRVW 120
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 81.3 bits (199), Expect = 3e-15
Identities = 67/282 (23%), Positives = 117/282 (41%), Gaps = 37/282 (13%)
Query: 441 PIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVG 500
PI H G V NG S G D I WN+ D Y TL G
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDC----DNY------ATLKG 107
Query: 501 HTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIG-CD 559
H+ AV L Y+ + L S S D TV +W+ + G++ + F+ C
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSE---------TGERVKRLKGHTSFVNSCY 158
Query: 560 PAH-----MVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTIT 614
PA + T + G+ ++D+ ++ Q+ + V + T I+
Sbjct: 159 PARRGPQLVCTGSDDGTVKLWDIRKKAAI--------QTFQNTYQVLAVTFNDTSDQIIS 210
Query: 615 AHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNL----DS 670
D IK +D + K+ ++M H D+VT L++ G YL+S + D ++R+W++
Sbjct: 211 GGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPK 270
Query: 671 KTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
+ CV+ + ++++ ++ + IA+ AD V+
Sbjct: 271 ERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/134 (21%), Positives = 62/134 (46%), Gaps = 14/134 (10%)
Query: 390 YTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHI 449
YT+R H D V L+ L++ + D+T+++W+++ P ++ + ++ F ++
Sbjct: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNL 288
Query: 450 GPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLA 509
L + S +G + +G D + W DT +L L GH ++ +A
Sbjct: 289 ---LRCSWSPDGSKIAAGSADRFVYVW----------DTTSRRILY-KLPGHAGSINEVA 334
Query: 510 YSGIKNQLLSCSAD 523
+ + ++S S+D
Sbjct: 335 FHPDEPIIISASSD 348
Score = 35.4 bits (80), Expect = 0.18
Identities = 14/37 (37%), Positives = 22/37 (59%)
Query: 390 YTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQ 426
Y L H + +AFHP EP++++AS D L + +Q
Sbjct: 321 YKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 80.1 bits (196), Expect = 7e-15
Identities = 79/326 (24%), Positives = 133/326 (40%), Gaps = 49/326 (15%)
Query: 389 KYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN-----LQKTVPAKKSASLDVEPIY 443
K+TL H V ++ F P L ++S D +K+W +KT+ K DV
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV---- 93
Query: 444 TFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTD 503
A SS+ S D T++ W++ S TL GH++
Sbjct: 94 ------------AWSSDSNLLVSASDDKTLKIWDVSSGKC-----------LKTLKGHSN 130
Query: 504 AVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHM 563
V+ ++ N ++S S D +VR+W+ + C+ T H P S D + +
Sbjct: 131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTG-KCLKTLPA---HSDPVSAVHFNRDGSLI 186
Query: 564 VTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKF 623
V+S G I+D + Q L L N ++ V P + A D +K
Sbjct: 187 VSSSYDGLCRIWDTASGQCLKTLIDD------DNPPVSFVKFSPNGKYILAATLDNTLKL 240
Query: 624 FDNKTGKMIHSMVAHLDAVTSLAVD---PNGIYLMSGSHDCSIRLWNLDSKTCVQEITAH 680
+D GK + + H + + + G +++SGS D + +WNL +K VQ++ H
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Query: 681 RKKLDESIYDVAFHSSKAYIASAGAD 706
+ + A H ++ IASA +
Sbjct: 301 ----TDVVISTACHPTENIIASAALE 322
Score = 67.4 bits (163), Expect = 4e-11
Identities = 60/259 (23%), Positives = 116/259 (44%), Gaps = 29/259 (11%)
Query: 427 KTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPY 486
K P K + +L +T H V S+ S NGE S D I+ W Y
Sbjct: 27 KPTPVKPNYALK----FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA-------Y 75
Query: 487 DTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKK 546
D ++G +G +D W S N L+S S D T+++W+ C+ T G
Sbjct: 76 DGKFEKTISGHKLGISDVAW----SSDSNLLVSASDDKTLKIWDVSSG-KCLKTLKGHSN 130
Query: 547 HGIPTSVDFIGCDPAHMVTSFNTGSAV-IYDLETSQSLVILSSQVDSGLQSNNHINRVVS 605
+ + + ++++ S + +V I+D++T + L L + D S H NR S
Sbjct: 131 YVFCCNFN----PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP--VSAVHFNRDGS 184
Query: 606 HPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDA-VTSLAVDPNGIYLMSGSHDCSIR 664
+ +++ D + +D +G+ + +++ + V+ + PNG Y+++ + D +++
Sbjct: 185 -----LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLK 239
Query: 665 LWNLDSKTCVQEITAHRKK 683
LW+ C++ T H+ +
Sbjct: 240 LWDYSKGKCLKTYTGHKNE 258
Score = 61.6 bits (148), Expect = 2e-09
Identities = 54/229 (23%), Positives = 104/229 (45%), Gaps = 25/229 (10%)
Query: 490 EPN-VLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKK-- 546
+PN L TL GHT AV + +S L S SAD +++W Y+G +
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG---------AYDGKFEKT 82
Query: 547 ---HGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRV 603
H + S D +V++ + + I+D+ + + L L +N++
Sbjct: 83 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH-------SNYVFCC 135
Query: 604 VSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSI 663
+P + ++ D ++ +D KTGK + ++ AH D V+++ + +G ++S S+D
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 664 RLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
R+W+ S C++ + + + V F + YI +A D K++
Sbjct: 196 RIWDTASGQCLKTLIDDD---NPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 35.4 bits (80), Expect = 0.18
Identities = 38/155 (24%), Positives = 64/155 (41%), Gaps = 26/155 (16%)
Query: 384 KTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIY 443
KT TL +H D V A+ F+ ++V++S D ++W+ + K+ D P
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD-TASGQCLKTLIDDDNP-- 215
Query: 444 TFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTD 503
PV + S NG+ + +D T++ W+ Y T GH +
Sbjct: 216 -------PVSFVKFSPNGKYILAATLDNTLKLWD-----------YSKGKCLKTYTGHKN 257
Query: 504 AVW----GLAYSGIKNQLLSCSADGTVRLWNPQEK 534
+ + +G K ++S S D V +WN Q K
Sbjct: 258 EKYCIFANFSVTGGK-WIVSGSEDNLVYIWNLQTK 291
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 80.1 bits (196), Expect = 7e-15
Identities = 79/326 (24%), Positives = 133/326 (40%), Gaps = 49/326 (15%)
Query: 389 KYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN-----LQKTVPAKKSASLDVEPIY 443
K+TL H V ++ F P L ++S D +K+W +KT+ K DV
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV---- 93
Query: 444 TFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTD 503
A SS+ S D T++ W++ S TL GH++
Sbjct: 94 ------------AWSSDSNLLVSASDDKTLKIWDVSSGKC-----------LKTLKGHSN 130
Query: 504 AVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHM 563
V+ ++ N ++S S D +VR+W+ + C+ T H P S D + +
Sbjct: 131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTG-KCLKTLPA---HSDPVSAVHFNRDGSLI 186
Query: 564 VTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKF 623
V+S G I+D + Q L L N ++ V P + A D +K
Sbjct: 187 VSSSYDGLCRIWDTASGQCLKTLIDD------DNPPVSFVKFSPNGKYILAATLDNTLKL 240
Query: 624 FDNKTGKMIHSMVAHLDAVTSLAVD---PNGIYLMSGSHDCSIRLWNLDSKTCVQEITAH 680
+D GK + + H + + + G +++SGS D + +WNL +K VQ++ H
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Query: 681 RKKLDESIYDVAFHSSKAYIASAGAD 706
+ + A H ++ IASA +
Sbjct: 301 ----TDVVISTACHPTENIIASAALE 322
Score = 67.4 bits (163), Expect = 4e-11
Identities = 60/259 (23%), Positives = 116/259 (44%), Gaps = 29/259 (11%)
Query: 427 KTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPY 486
K P K + +L +T H V S+ S NGE S D I+ W Y
Sbjct: 27 KPTPVKPNYALK----FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA-------Y 75
Query: 487 DTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKK 546
D ++G +G +D W S N L+S S D T+++W+ C+ T G
Sbjct: 76 DGKFEKTISGHKLGISDVAW----SSDSNLLVSASDDKTLKIWDVSSG-KCLKTLKGHSN 130
Query: 547 HGIPTSVDFIGCDPAHMVTSFNTGSAV-IYDLETSQSLVILSSQVDSGLQSNNHINRVVS 605
+ + + ++++ S + +V I+D++T + L L + D S H NR S
Sbjct: 131 YVFCCNFN----PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP--VSAVHFNRDGS 184
Query: 606 HPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDA-VTSLAVDPNGIYLMSGSHDCSIR 664
+ +++ D + +D +G+ + +++ + V+ + PNG Y+++ + D +++
Sbjct: 185 -----LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLK 239
Query: 665 LWNLDSKTCVQEITAHRKK 683
LW+ C++ T H+ +
Sbjct: 240 LWDYSKGKCLKTYTGHKNE 258
Score = 61.6 bits (148), Expect = 2e-09
Identities = 54/229 (23%), Positives = 104/229 (45%), Gaps = 25/229 (10%)
Query: 490 EPN-VLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKK-- 546
+PN L TL GHT AV + +S L S SAD +++W Y+G +
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG---------AYDGKFEKT 82
Query: 547 ---HGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRV 603
H + S D +V++ + + I+D+ + + L L +N++
Sbjct: 83 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH-------SNYVFCC 135
Query: 604 VSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSI 663
+P + ++ D ++ +D KTGK + ++ AH D V+++ + +G ++S S+D
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 664 RLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
R+W+ S C++ + + + V F + YI +A D K++
Sbjct: 196 RIWDTASGQCLKTLIDDD---NPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 35.4 bits (80), Expect = 0.18
Identities = 38/155 (24%), Positives = 64/155 (41%), Gaps = 26/155 (16%)
Query: 384 KTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIY 443
KT TL +H D V A+ F+ ++V++S D ++W+ + K+ D P
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD-TASGQCLKTLIDDDNP-- 215
Query: 444 TFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTD 503
PV + S NG+ + +D T++ W+ Y T GH +
Sbjct: 216 -------PVSFVKFSPNGKYILAATLDNTLKLWD-----------YSKGKCLKTYTGHKN 257
Query: 504 AVW----GLAYSGIKNQLLSCSADGTVRLWNPQEK 534
+ + +G K ++S S D V +WN Q K
Sbjct: 258 EKYCIFANFSVTGGK-WIVSGSEDNLVYIWNLQTK 291
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 78.6 bits (192), Expect = 2e-14
Identities = 78/352 (22%), Positives = 133/352 (37%), Gaps = 68/352 (19%)
Query: 387 NPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFR 446
N LR H V A++PV +L + S D T ++WNL + S L +
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG-STQLVLRHCIREG 228
Query: 447 AHIGP----VLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHT 502
H P V SL +S+G G D + W E LA TL H
Sbjct: 229 GHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT------------ENGNLASTLGQHK 276
Query: 503 DAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAH 562
++ L ++ N +LS D T +W+ + G+ K P
Sbjct: 277 GPIFALKWNKKGNYVLSAGVDKTTIIWD---------AHTGEAKQQFP------------ 315
Query: 563 MVTSFNTGSAVIYDLETSQSLVILSSQV---------DSGLQS----NNHINRVVSHPTL 609
F++ A+ D + + + S+ + D +++ N +N + P+
Sbjct: 316 ----FHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSG 371
Query: 610 PVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNG---------IYLMSGSHD 660
+ + +D +K + K +H + AH + ++ P G I L S S D
Sbjct: 372 MLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFD 431
Query: 661 CSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
++RLW+++ C + H+ E +Y VAF Y+AS D ++
Sbjct: 432 STVRLWDVEQGVCTHTLMKHQ----EPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 60.5 bits (145), Expect = 5e-09
Identities = 70/364 (19%), Positives = 126/364 (34%), Gaps = 109/364 (29%)
Query: 373 YDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAK 432
+D+P+NKD WN TL L S D ++W + +
Sbjct: 230 HDVPSNKDVTSLDWNSDGTL------------------LAMGSYDGFARIWTENGNLAS- 270
Query: 433 KSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN---------MPSPSV 483
T H GP+ +L + G S G+D T W+ P S
Sbjct: 271 -----------TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSA 319
Query: 484 DPYDTYEPNVL---------------------AGTLVGHTDAVWGLAYSGIKNQLLSCSA 522
D N + T GHT+ V + + L SCS
Sbjct: 320 PALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSD 379
Query: 523 DGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQS 582
D T+++W+ ++ A ++DL+
Sbjct: 380 DMTLKIWSMKQ-------------------------------------DACVHDLQAHSK 402
Query: 583 LVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAV 642
+ +G ++N + + + +A D ++ +D + G H+++ H + V
Sbjct: 403 EIYTIKWSPTGPATSNPNSSI-------MLASASFDSTVRLWDVEQGVCTHTLMKHQEPV 455
Query: 643 TSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIAS 702
S+A P+G YL SGS D + +WN S + V H + I++V +++ + +
Sbjct: 456 YSVAFSPDGKYLASGSFDKYVHIWNTQSGSLV-----HSYQGTGGIFEVCWNARGDKVGA 510
Query: 703 AGAD 706
+ +D
Sbjct: 511 SASD 514
Score = 44.3 bits (103), Expect = 4e-04
Identities = 63/273 (23%), Positives = 99/273 (36%), Gaps = 53/273 (19%)
Query: 460 NGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLS 519
N E +G + + N P D P A L GH V+ A++ + + L S
Sbjct: 137 NREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLAS 196
Query: 520 CSADGTVRLWNPQEK--------LPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGS 571
S D T R+WN E + C G H +P++ D D T GS
Sbjct: 197 GSGDSTARIWNLNENSNGGSTQLVLRHCIREGG--HDVPSNKDVTSLDWNSDGTLLAMGS 254
Query: 572 AVIYD----LETSQSLVILSSQVDSG----LQSNNHINRVVSHPTLPVTI--TAHE---- 617
YD + T + + G L+ N N V+S TI AH
Sbjct: 255 ---YDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAK 311
Query: 618 ---------------DRHIKFFDNKTGKMIH-----------SMVAHLDAVTSLAVDPNG 651
++ F T IH + H + V ++ DP+G
Sbjct: 312 QQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSG 371
Query: 652 IYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKL 684
+ L S S D ++++W++ CV ++ AH K++
Sbjct: 372 MLLASCSDDMTLKIWSMKQDACVHDLQAHSKEI 404
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 78.6 bits (192), Expect = 2e-14
Identities = 78/352 (22%), Positives = 133/352 (37%), Gaps = 68/352 (19%)
Query: 387 NPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFR 446
N LR H V A++PV +L + S D T ++WNL + S L +
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG-STQLVLRHCIREG 228
Query: 447 AHIGP----VLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHT 502
H P V SL +S+G G D + W E LA TL H
Sbjct: 229 GHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT------------ENGNLASTLGQHK 276
Query: 503 DAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAH 562
++ L ++ N +LS D T +W+ + G+ K P
Sbjct: 277 GPIFALKWNKKGNYVLSAGVDKTTIIWD---------AHTGEAKQQFP------------ 315
Query: 563 MVTSFNTGSAVIYDLETSQSLVILSSQV---------DSGLQS----NNHINRVVSHPTL 609
F++ A+ D + + + S+ + D +++ N +N + P+
Sbjct: 316 ----FHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSG 371
Query: 610 PVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNG---------IYLMSGSHD 660
+ + +D +K + K +H + AH + ++ P G I L S S D
Sbjct: 372 MLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFD 431
Query: 661 CSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
++RLW+++ C + H+ E +Y VAF Y+AS D ++
Sbjct: 432 STVRLWDVEQGVCTHTLMKHQ----EPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 60.5 bits (145), Expect = 5e-09
Identities = 70/364 (19%), Positives = 126/364 (34%), Gaps = 109/364 (29%)
Query: 373 YDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAK 432
+D+P+NKD WN TL L S D ++W + +
Sbjct: 230 HDVPSNKDVTSLDWNSDGTL------------------LAMGSYDGFARIWTENGNLAS- 270
Query: 433 KSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN---------MPSPSV 483
T H GP+ +L + G S G+D T W+ P S
Sbjct: 271 -----------TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSA 319
Query: 484 DPYDTYEPNVL---------------------AGTLVGHTDAVWGLAYSGIKNQLLSCSA 522
D N + T GHT+ V + + L SCS
Sbjct: 320 PALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSD 379
Query: 523 DGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQS 582
D T+++W+ ++ A ++DL+
Sbjct: 380 DMTLKIWSMKQ-------------------------------------DACVHDLQAHSK 402
Query: 583 LVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAV 642
+ +G ++N + + + +A D ++ +D + G H+++ H + V
Sbjct: 403 EIYTIKWSPTGPATSNPNSSI-------MLASASFDSTVRLWDVEQGVCTHTLMKHQEPV 455
Query: 643 TSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIAS 702
S+A P+G YL SGS D + +WN S + V H + I++V +++ + +
Sbjct: 456 YSVAFSPDGKYLASGSFDKYVHIWNTQSGSLV-----HSYQGTGGIFEVCWNARGDKVGA 510
Query: 703 AGAD 706
+ +D
Sbjct: 511 SASD 514
Score = 44.3 bits (103), Expect = 4e-04
Identities = 63/273 (23%), Positives = 99/273 (36%), Gaps = 53/273 (19%)
Query: 460 NGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLS 519
N E +G + + N P D P A L GH V+ A++ + + L S
Sbjct: 137 NREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLAS 196
Query: 520 CSADGTVRLWNPQEK--------LPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGS 571
S D T R+WN E + C G H +P++ D D T GS
Sbjct: 197 GSGDSTARIWNLNENSNGGSTQLVLRHCIREGG--HDVPSNKDVTSLDWNSDGTLLAMGS 254
Query: 572 AVIYD----LETSQSLVILSSQVDSG----LQSNNHINRVVSHPTLPVTI--TAHE---- 617
YD + T + + G L+ N N V+S TI AH
Sbjct: 255 ---YDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAK 311
Query: 618 ---------------DRHIKFFDNKTGKMIH-----------SMVAHLDAVTSLAVDPNG 651
++ F T IH + H + V ++ DP+G
Sbjct: 312 QQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSG 371
Query: 652 IYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKL 684
+ L S S D ++++W++ CV ++ AH K++
Sbjct: 372 MLLASCSDDMTLKIWSMKQDACVHDLQAHSKEI 404
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 78.6 bits (192), Expect = 2e-14
Identities = 78/352 (22%), Positives = 133/352 (37%), Gaps = 68/352 (19%)
Query: 387 NPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFR 446
N LR H V A++PV +L + S D T ++WNL + S L +
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG-STQLVLRHCIREG 228
Query: 447 AHIGP----VLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHT 502
H P V SL +S+G G D + W E LA TL H
Sbjct: 229 GHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT------------ENGNLASTLGQHK 276
Query: 503 DAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAH 562
++ L ++ N +LS D T +W+ + G+ K P
Sbjct: 277 GPIFALKWNKKGNYVLSAGVDKTTIIWD---------AHTGEAKQQFP------------ 315
Query: 563 MVTSFNTGSAVIYDLETSQSLVILSSQV---------DSGLQS----NNHINRVVSHPTL 609
F++ A+ D + + + S+ + D +++ N +N + P+
Sbjct: 316 ----FHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSG 371
Query: 610 PVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNG---------IYLMSGSHD 660
+ + +D +K + K +H + AH + ++ P G I L S S D
Sbjct: 372 MLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFD 431
Query: 661 CSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
++RLW+++ C + H+ E +Y VAF Y+AS D ++
Sbjct: 432 STVRLWDVEQGVCTHTLMKHQ----EPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 60.5 bits (145), Expect = 5e-09
Identities = 70/364 (19%), Positives = 126/364 (34%), Gaps = 109/364 (29%)
Query: 373 YDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAK 432
+D+P+NKD WN TL L S D ++W + +
Sbjct: 230 HDVPSNKDVTSLDWNSDGTL------------------LAMGSYDGFARIWTENGNLAS- 270
Query: 433 KSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN---------MPSPSV 483
T H GP+ +L + G S G+D T W+ P S
Sbjct: 271 -----------TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSA 319
Query: 484 DPYDTYEPNVL---------------------AGTLVGHTDAVWGLAYSGIKNQLLSCSA 522
D N + T GHT+ V + + L SCS
Sbjct: 320 PALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSD 379
Query: 523 DGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQS 582
D T+++W+ ++ A ++DL+
Sbjct: 380 DMTLKIWSMKQ-------------------------------------DACVHDLQAHSK 402
Query: 583 LVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAV 642
+ +G ++N + + + +A D ++ +D + G H+++ H + V
Sbjct: 403 EIYTIKWSPTGPATSNPNSSI-------MLASASFDSTVRLWDVEQGVCTHTLMKHQEPV 455
Query: 643 TSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIAS 702
S+A P+G YL SGS D + +WN S + V H + I++V +++ + +
Sbjct: 456 YSVAFSPDGKYLASGSFDKYVHIWNTQSGSLV-----HSYQGTGGIFEVCWNARGDKVGA 510
Query: 703 AGAD 706
+ +D
Sbjct: 511 SASD 514
Score = 44.3 bits (103), Expect = 4e-04
Identities = 63/273 (23%), Positives = 99/273 (36%), Gaps = 53/273 (19%)
Query: 460 NGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLS 519
N E +G + + N P D P A L GH V+ A++ + + L S
Sbjct: 137 NREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLAS 196
Query: 520 CSADGTVRLWNPQEK--------LPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGS 571
S D T R+WN E + C G H +P++ D D T GS
Sbjct: 197 GSGDSTARIWNLNENSNGGSTQLVLRHCIREGG--HDVPSNKDVTSLDWNSDGTLLAMGS 254
Query: 572 AVIYD----LETSQSLVILSSQVDSG----LQSNNHINRVVSHPTLPVTI--TAHE---- 617
YD + T + + G L+ N N V+S TI AH
Sbjct: 255 ---YDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAK 311
Query: 618 ---------------DRHIKFFDNKTGKMIH-----------SMVAHLDAVTSLAVDPNG 651
++ F T IH + H + V ++ DP+G
Sbjct: 312 QQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSG 371
Query: 652 IYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKL 684
+ L S S D ++++W++ CV ++ AH K++
Sbjct: 372 MLLASCSDDMTLKIWSMKQDACVHDLQAHSKEI 404
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 77.4 bits (189), Expect = 4e-14
Identities = 62/221 (28%), Positives = 102/221 (46%), Gaps = 30/221 (13%)
Query: 461 GEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSC 520
G + SG D T++ W+ + TLVGHT VW N ++S
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKC-----------LRTLVGHTGGVWSSQMRD--NIIISG 319
Query: 521 SADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETS 580
S D T+++WN E CI T +G ++V + +V+ + ++D+ET
Sbjct: 320 STDRTLKVWNA-ETGECIHTL-----YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 373
Query: 581 QSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLD 640
Q L +L V + RVVS D +K +D +T +H++ H +
Sbjct: 374 QCLHVLMGHVAAVRCVQYDGRRVVS---------GAYDFMVKVWDPETETCLHTLQGHTN 424
Query: 641 AVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHR 681
V SL D GI+++SGS D SIR+W++++ C+ +T H+
Sbjct: 425 RVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ 463
Score = 71.2 bits (173), Expect = 3e-12
Identities = 68/292 (23%), Positives = 133/292 (45%), Gaps = 52/292 (17%)
Query: 391 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIG 450
TL H GV + + ++++ S D TLK+WN + E I+T H
Sbjct: 298 TLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG-----------ECIHTLYGHTS 344
Query: 451 PVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAY 510
V + + + ++ SG DAT++ W++ E L+GH AV + Y
Sbjct: 345 TVRCMHL--HEKRVVSGSRDATLRVWDI-----------ETGQCLHVLMGHVAAVRCVQY 391
Query: 511 SGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTG 570
G +++S + D V++W+P+ + C+ T G V + D H+V+
Sbjct: 392 DG--RRVVSGAYDFMVKVWDPETE-TCLHTLQGHTNR-----VYSLQFDGIHVVSGSLDT 443
Query: 571 SAVIYDLETSQSLVILS--SQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKT 628
S ++D+ET + L+ + SG++ ++I ++ + D +K +D KT
Sbjct: 444 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNI-----------LVSGNADSTVKIWDIKT 492
Query: 629 GKMIHSMVA---HLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEI 677
G+ + ++ H AVT L + N ++++ S D +++LW+L + ++ +
Sbjct: 493 GQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 542
Score = 65.1 bits (157), Expect = 2e-10
Identities = 65/276 (23%), Positives = 115/276 (41%), Gaps = 51/276 (18%)
Query: 411 LVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 470
+V+ S+D+TLK+W+ ++ + + T H G V S + N SG D
Sbjct: 276 IVSGSDDNTLKVWS-----------AVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTD 322
Query: 471 ATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWN 530
T++ WN E TL GHT V + + +++S S D T+R+W+
Sbjct: 323 RTLKVWNA-----------ETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 369
Query: 531 PQEKLPCICTYNGDKKHGIPTSVDFIGC---DPAHMVTSFNTGSAVIYDLETSQSLVILS 587
+ G H + V + C D +V+ ++D ET L L
Sbjct: 370 IE---------TGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQ 420
Query: 588 SQVDSGLQSNNHINRVVSHPTLPVTITAHE-DRHIKFFDNKTGKMIHSMVAHLDAVTSLA 646
H NRV S + + + D I+ +D +TG IH++ H + +
Sbjct: 421 G----------HTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGME 470
Query: 647 VDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRK 682
+ N L+SG+ D ++++W++ + C+Q + K
Sbjct: 471 LKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNK 504
Score = 50.8 bits (120), Expect = 4e-06
Identities = 48/217 (22%), Positives = 101/217 (46%), Gaps = 28/217 (12%)
Query: 498 LVGHTD-AVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFI 556
L GH D + L + G N+++S S D T+++W+ C+ T G T +
Sbjct: 258 LKGHDDHVITCLQFCG--NRIVSGSDDNTLKVWSAVTG-KCLRTLVGH------TGGVWS 308
Query: 557 GCDPAHMVTSFNTGSAV-IYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITA 615
+++ S +T + +++ ET + + L + + H RVVS
Sbjct: 309 SQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVS---------G 359
Query: 616 HEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQ 675
D ++ +D +TG+ +H ++ H+ AV + D G ++SG++D +++W+ +++TC+
Sbjct: 360 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLH 417
Query: 676 EITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
+ H + +Y + F ++ S D +V+
Sbjct: 418 TLQGHTNR----VYSLQFDG--IHVVSGSLDTSIRVW 448
Score = 40.4 bits (93), Expect = 0.006
Identities = 39/159 (24%), Positives = 71/159 (44%), Gaps = 36/159 (22%)
Query: 380 DAFRKTWNPK-----YTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKS 434
D K W+P+ +TL+ H + V +L F + +V+ S D ++++W+++
Sbjct: 402 DFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETG------ 453
Query: 435 ASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVL 494
I+T H + + N SG D+T++ W++ +
Sbjct: 454 -----NCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC----------- 495
Query: 495 AGTLVG---HTDAVWGLAYSGIKNQLLSCSADGTVRLWN 530
TL G H AV L ++ KN +++ S DGTV+LW+
Sbjct: 496 LQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWD 532
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 77.4 bits (189), Expect = 4e-14
Identities = 62/221 (28%), Positives = 102/221 (46%), Gaps = 30/221 (13%)
Query: 461 GEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSC 520
G + SG D T++ W+ + TLVGHT VW N ++S
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKC-----------LRTLVGHTGGVWSSQMRD--NIIISG 437
Query: 521 SADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETS 580
S D T+++WN E CI T +G ++V + +V+ + ++D+ET
Sbjct: 438 STDRTLKVWNA-ETGECIHTL-----YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 491
Query: 581 QSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLD 640
Q L +L V + RVVS D +K +D +T +H++ H +
Sbjct: 492 QCLHVLMGHVAAVRCVQYDGRRVVS---------GAYDFMVKVWDPETETCLHTLQGHTN 542
Query: 641 AVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHR 681
V SL D GI+++SGS D SIR+W++++ C+ +T H+
Sbjct: 543 RVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ 581
Score = 71.2 bits (173), Expect = 3e-12
Identities = 68/292 (23%), Positives = 133/292 (45%), Gaps = 52/292 (17%)
Query: 391 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIG 450
TL H GV + + ++++ S D TLK+WN + E I+T H
Sbjct: 416 TLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG-----------ECIHTLYGHTS 462
Query: 451 PVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAY 510
V + + + ++ SG DAT++ W++ E L+GH AV + Y
Sbjct: 463 TVRCMHL--HEKRVVSGSRDATLRVWDI-----------ETGQCLHVLMGHVAAVRCVQY 509
Query: 511 SGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTG 570
G +++S + D V++W+P+ + C+ T G V + D H+V+
Sbjct: 510 DG--RRVVSGAYDFMVKVWDPETE-TCLHTLQGHTNR-----VYSLQFDGIHVVSGSLDT 561
Query: 571 SAVIYDLETSQSLVILS--SQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKT 628
S ++D+ET + L+ + SG++ ++I ++ + D +K +D KT
Sbjct: 562 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNI-----------LVSGNADSTVKIWDIKT 610
Query: 629 GKMIHSMVA---HLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEI 677
G+ + ++ H AVT L + N ++++ S D +++LW+L + ++ +
Sbjct: 611 GQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 660
Score = 65.1 bits (157), Expect = 2e-10
Identities = 65/276 (23%), Positives = 115/276 (41%), Gaps = 51/276 (18%)
Query: 411 LVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 470
+V+ S+D+TLK+W+ ++ + + T H G V S + N SG D
Sbjct: 394 IVSGSDDNTLKVWS-----------AVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTD 440
Query: 471 ATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWN 530
T++ WN E TL GHT V + + +++S S D T+R+W+
Sbjct: 441 RTLKVWNA-----------ETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 487
Query: 531 PQEKLPCICTYNGDKKHGIPTSVDFIGC---DPAHMVTSFNTGSAVIYDLETSQSLVILS 587
+ G H + V + C D +V+ ++D ET L L
Sbjct: 488 IE---------TGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQ 538
Query: 588 SQVDSGLQSNNHINRVVSHPTLPVTITAHE-DRHIKFFDNKTGKMIHSMVAHLDAVTSLA 646
H NRV S + + + D I+ +D +TG IH++ H + +
Sbjct: 539 G----------HTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGME 588
Query: 647 VDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRK 682
+ N L+SG+ D ++++W++ + C+Q + K
Sbjct: 589 LKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNK 622
Score = 50.8 bits (120), Expect = 4e-06
Identities = 48/217 (22%), Positives = 101/217 (46%), Gaps = 28/217 (12%)
Query: 498 LVGHTD-AVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFI 556
L GH D + L + G N+++S S D T+++W+ C+ T G T +
Sbjct: 376 LKGHDDHVITCLQFCG--NRIVSGSDDNTLKVWSAVTG-KCLRTLVGH------TGGVWS 426
Query: 557 GCDPAHMVTSFNTGSAV-IYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITA 615
+++ S +T + +++ ET + + L + + H RVVS
Sbjct: 427 SQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVS---------G 477
Query: 616 HEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQ 675
D ++ +D +TG+ +H ++ H+ AV + D G ++SG++D +++W+ +++TC+
Sbjct: 478 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLH 535
Query: 676 EITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
+ H + +Y + F ++ S D +V+
Sbjct: 536 TLQGHTNR----VYSLQFDG--IHVVSGSLDTSIRVW 566
Score = 40.4 bits (93), Expect = 0.006
Identities = 39/159 (24%), Positives = 71/159 (44%), Gaps = 36/159 (22%)
Query: 380 DAFRKTWNPK-----YTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKS 434
D K W+P+ +TL+ H + V +L F + +V+ S D ++++W+++
Sbjct: 520 DFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETG------ 571
Query: 435 ASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVL 494
I+T H + + N SG D+T++ W++ +
Sbjct: 572 -----NCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC----------- 613
Query: 495 AGTLVG---HTDAVWGLAYSGIKNQLLSCSADGTVRLWN 530
TL G H AV L ++ KN +++ S DGTV+LW+
Sbjct: 614 LQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWD 650
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 77.4 bits (189), Expect = 4e-14
Identities = 62/221 (28%), Positives = 102/221 (46%), Gaps = 30/221 (13%)
Query: 461 GEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSC 520
G + SG D T++ W+ + TLVGHT VW N ++S
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKC-----------LRTLVGHTGGVWSSQMRD--NIIISG 357
Query: 521 SADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETS 580
S D T+++WN E CI T +G ++V + +V+ + ++D+ET
Sbjct: 358 STDRTLKVWNA-ETGECIHTL-----YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 411
Query: 581 QSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLD 640
Q L +L V + RVVS D +K +D +T +H++ H +
Sbjct: 412 QCLHVLMGHVAAVRCVQYDGRRVVS---------GAYDFMVKVWDPETETCLHTLQGHTN 462
Query: 641 AVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHR 681
V SL D GI+++SGS D SIR+W++++ C+ +T H+
Sbjct: 463 RVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ 501
Score = 71.2 bits (173), Expect = 3e-12
Identities = 68/292 (23%), Positives = 133/292 (45%), Gaps = 52/292 (17%)
Query: 391 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIG 450
TL H GV + + ++++ S D TLK+WN + E I+T H
Sbjct: 336 TLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG-----------ECIHTLYGHTS 382
Query: 451 PVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAY 510
V + + + ++ SG DAT++ W++ E L+GH AV + Y
Sbjct: 383 TVRCMHL--HEKRVVSGSRDATLRVWDI-----------ETGQCLHVLMGHVAAVRCVQY 429
Query: 511 SGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTG 570
G +++S + D V++W+P+ + C+ T G V + D H+V+
Sbjct: 430 DG--RRVVSGAYDFMVKVWDPETE-TCLHTLQGHTNR-----VYSLQFDGIHVVSGSLDT 481
Query: 571 SAVIYDLETSQSLVILS--SQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKT 628
S ++D+ET + L+ + SG++ ++I ++ + D +K +D KT
Sbjct: 482 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNI-----------LVSGNADSTVKIWDIKT 530
Query: 629 GKMIHSMVA---HLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEI 677
G+ + ++ H AVT L + N ++++ S D +++LW+L + ++ +
Sbjct: 531 GQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 580
Score = 65.1 bits (157), Expect = 2e-10
Identities = 65/276 (23%), Positives = 115/276 (41%), Gaps = 51/276 (18%)
Query: 411 LVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 470
+V+ S+D+TLK+W+ ++ + + T H G V S + N SG D
Sbjct: 314 IVSGSDDNTLKVWS-----------AVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTD 360
Query: 471 ATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWN 530
T++ WN E TL GHT V + + +++S S D T+R+W+
Sbjct: 361 RTLKVWNA-----------ETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 407
Query: 531 PQEKLPCICTYNGDKKHGIPTSVDFIGC---DPAHMVTSFNTGSAVIYDLETSQSLVILS 587
+ G H + V + C D +V+ ++D ET L L
Sbjct: 408 IE---------TGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQ 458
Query: 588 SQVDSGLQSNNHINRVVSHPTLPVTITAHE-DRHIKFFDNKTGKMIHSMVAHLDAVTSLA 646
H NRV S + + + D I+ +D +TG IH++ H + +
Sbjct: 459 G----------HTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGME 508
Query: 647 VDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRK 682
+ N L+SG+ D ++++W++ + C+Q + K
Sbjct: 509 LKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNK 542
Score = 50.8 bits (120), Expect = 4e-06
Identities = 48/217 (22%), Positives = 101/217 (46%), Gaps = 28/217 (12%)
Query: 498 LVGHTD-AVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFI 556
L GH D + L + G N+++S S D T+++W+ C+ T G T +
Sbjct: 296 LKGHDDHVITCLQFCG--NRIVSGSDDNTLKVWSAVTG-KCLRTLVGH------TGGVWS 346
Query: 557 GCDPAHMVTSFNTGSAV-IYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITA 615
+++ S +T + +++ ET + + L + + H RVVS
Sbjct: 347 SQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVS---------G 397
Query: 616 HEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQ 675
D ++ +D +TG+ +H ++ H+ AV + D G ++SG++D +++W+ +++TC+
Sbjct: 398 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLH 455
Query: 676 EITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
+ H + +Y + F ++ S D +V+
Sbjct: 456 TLQGHTNR----VYSLQFDG--IHVVSGSLDTSIRVW 486
Score = 40.4 bits (93), Expect = 0.006
Identities = 39/159 (24%), Positives = 71/159 (44%), Gaps = 36/159 (22%)
Query: 380 DAFRKTWNPK-----YTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKS 434
D K W+P+ +TL+ H + V +L F + +V+ S D ++++W+++
Sbjct: 440 DFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETG------ 491
Query: 435 ASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVL 494
I+T H + + N SG D+T++ W++ +
Sbjct: 492 -----NCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC----------- 533
Query: 495 AGTLVG---HTDAVWGLAYSGIKNQLLSCSADGTVRLWN 530
TL G H AV L ++ KN +++ S DGTV+LW+
Sbjct: 534 LQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWD 570
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 76.6 bits (187), Expect = 7e-14
Identities = 76/275 (27%), Positives = 115/275 (41%), Gaps = 38/275 (13%)
Query: 395 HFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLS 454
H D + FHP L T+S D T+KLW+L K + I TF H V S
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKG-----------DCILTFEGHSRAVWS 441
Query: 455 LAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIK 514
S G S +D T + W++ S TL GHTD+V + +
Sbjct: 442 CTWHSCGNFVASSSLDKTSKIWDVNSERC-----------RCTLYGHTDSVNSIEFFPFS 490
Query: 515 NQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDP-AHMVTSFNT-GSA 572
N LL+ SAD T+ +W+ + IC +G S++ DP HM+ S + G
Sbjct: 491 NTLLTSSADKTLSIWDARTG---ICE---QSLYGHMHSINDAIFDPRGHMIASCDACGVT 544
Query: 573 VIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMI 632
++D +V +D G N +N S L A + I D K+G+ I
Sbjct: 545 KLWDFRKLLPIV----SIDIGPSPGNEVNFDSSGRVL---AQASGNGVIHLLDLKSGE-I 596
Query: 633 HSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 667
H ++ H + ++ +G L SG D ++R W+
Sbjct: 597 HKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
Score = 52.8 bits (125), Expect = 1e-06
Identities = 56/245 (22%), Positives = 103/245 (42%), Gaps = 24/245 (9%)
Query: 424 NLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSV 483
NL + + A D + FR H PV +++ + + S G D + +P +V
Sbjct: 327 NLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNV 386
Query: 484 DPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNG 543
+L G GHTD + + ++L + S D TV+LW+ K CI T+ G
Sbjct: 387 ---------LLTG--FGHTDWLSDCCFHPSGDKLATSSGDTTVKLWD-LCKGDCILTFEG 434
Query: 544 DKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRV 603
+ S + C +S + S I+D+ + + L DS +N +
Sbjct: 435 HSR--AVWSCTWHSCGNFVASSSLDKTSK-IWDVNSERCRCTLYGHTDS-------VNSI 484
Query: 604 VSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSI 663
P +T+ D+ + +D +TG S+ H+ ++ DP G ++++ C +
Sbjct: 485 EFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRG-HMIASCDACGV 543
Query: 664 -RLWN 667
+LW+
Sbjct: 544 TKLWD 548
Score = 43.9 bits (102), Expect = 5e-04
Identities = 24/113 (21%), Positives = 52/113 (46%), Gaps = 4/113 (3%)
Query: 600 INRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSH 659
++ V P + ++ EDR K ++ + H D ++ P+G L + S
Sbjct: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414
Query: 660 DCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
D +++LW+L C+ H + +++ +HS ++AS+ D +K++
Sbjct: 415 DTTVKLWDLCKGDCILTFEGHSR----AVWSCTWHSCGNFVASSSLDKTSKIW 463
Score = 40.4 bits (93), Expect = 0.006
Identities = 23/95 (24%), Positives = 47/95 (49%), Gaps = 4/95 (4%)
Query: 618 DRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEI 677
D+ K +D + + ++ H D+V S+ P L++ S D ++ +W+ + C Q +
Sbjct: 457 DKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSL 516
Query: 678 TAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
H ++++I+D H IAS A + K++
Sbjct: 517 YGHMHSINDAIFDPRGH----MIASCDACGVTKLW 547
Score = 36.6 bits (83), Expect = 0.083
Identities = 56/251 (22%), Positives = 92/251 (36%), Gaps = 60/251 (23%)
Query: 327 TEWAEPITF-PSGGGKSFIMGSDDVLLSVLGLGDL---------ADLTVTNDADYSYDLP 376
T+W F PSG + G V L L GD A + T + ++
Sbjct: 394 TDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVAS 453
Query: 377 ANKDAFRKTWNP-----KYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPA 431
++ D K W+ + TL H D V ++ F P L+T+S D TL +W+ + +
Sbjct: 454 SSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICE 513
Query: 432 KK-------------------SASLD---VEPIYTFRAHIGPVLSLAI----------SS 459
+ AS D V ++ FR + P++S+ I S
Sbjct: 514 QSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLL-PIVSIDIGPSPGNEVNFDS 572
Query: 460 NGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLS 519
+G + I ++ S + L+GH + + +S L S
Sbjct: 573 SGRVLAQASGNGVIHLLDLKSGEIH------------KLMGHENEAHTVVFSHDGEILFS 620
Query: 520 CSADGTVRLWN 530
+DGTVR W+
Sbjct: 621 GGSDGTVRTWS 631
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.133 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,108,432
Number of Sequences: 37866
Number of extensions: 1603845
Number of successful extensions: 16642
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 305
Number of HSP's successfully gapped in prelim test: 492
Number of HSP's that attempted gapping in prelim test: 9302
Number of HSP's gapped (non-prelim): 5270
length of query: 713
length of database: 18,247,518
effective HSP length: 109
effective length of query: 604
effective length of database: 14,120,124
effective search space: 8528554896
effective search space used: 8528554896
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.