Search of human proteins with 9789987

Search of human proteins with 9789987

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|9789987 potassium voltage-gated channel, Shal-related
subfamily, member 2 [Homo sapiens]
         (630 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|9789987 potassium voltage-gated channel, Shal-related subfami...  1266   0.0  
gi|27436986 potassium voltage-gated channel, Shal-related subfam...   970   0.0  
gi|27436984 potassium voltage-gated channel, Shal-related subfam...   959   0.0  
gi|27436981 potassium voltage-gated channel, Shal-related subfam...   828   0.0  
gi|27436974 potassium voltage-gated channel, Shab-related subfam...   288   1e-77
gi|4826784 potassium voltage-gated channel, Shab-related subfami...   280   3e-75
gi|4826786 Shaw-related voltage-gated potassium channel protein ...   273   3e-73
gi|163792201 Shaw-related voltage-gated potassium channel protei...   272   6e-73
gi|25952092 potassium voltage-gated channel, shaker-related subf...   268   9e-72
gi|4826782 potassium voltage-gated channel, shaker-related subfa...   264   2e-70
gi|88758565 potassium voltage-gated channel, shaker-related subf...   262   8e-70
gi|88758576 Shaw-related voltage-gated potassium channel protein...   261   1e-69
gi|24497462 Shaw-related voltage-gated potassium channel protein...   259   4e-69
gi|24497464 Shaw-related voltage-gated potassium channel protein...   259   4e-69
gi|119395748 potassium voltage-gated channel subfamily A member ...   258   2e-68
gi|4504817 potassium voltage-gated channel, shaker-related subfa...   257   3e-68
gi|5031819 potassium voltage-gated channel, shaker-related subfa...   256   3e-68
gi|25952087 potassium voltage-gated channel, shaker-related subf...   254   1e-67
gi|24497460 Shaw-related voltage-gated potassium channel protein...   253   4e-67
gi|4504821 potassium voltage-gated channel, shaker-related subfa...   247   2e-65
gi|20070166 potassium voltage-gated channel, subfamily F, member...   243   5e-64
gi|21217561 Shaw-related voltage-gated potassium channel protein...   241   2e-63
gi|21217563 Shaw-related voltage-gated potassium channel protein...   241   2e-63
gi|24497458 Shaw-related voltage-gated potassium channel protein...   241   2e-63
gi|25952108 potassium voltage-gated channel delayed-rectifier pr...   236   4e-62
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]    231   1e-60
gi|27436988 potassium voltage-gated channel, subfamily G, member...   224   2e-58
gi|13492973 potassium voltage-gated channel delayed-rectifier pr...   216   5e-56
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ...   216   7e-56
gi|19071574 potassium voltage-gated channel, subfamily G, member...   209   8e-54

>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
           member 2 [Homo sapiens]
          Length = 630

 Score = 1266 bits (3276), Expect = 0.0
 Identities = 630/630 (100%), Positives = 630/630 (100%)

Query: 1   MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLE 60
           MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLE
Sbjct: 1   MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLE 60

Query: 61  RYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELA 120
           RYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELA
Sbjct: 61  RYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELA 120

Query: 121 FFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGESALPTMTARQRVWRAFENPHT 180
           FFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGESALPTMTARQRVWRAFENPHT
Sbjct: 121 FFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGESALPTMTARQRVWRAFENPHT 180

Query: 181 STMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIF 240
           STMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIF
Sbjct: 181 STMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIF 240

Query: 241 TVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRI 300
           TVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRI
Sbjct: 241 TVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRI 300

Query: 301 FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAA 360
           FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAA
Sbjct: 301 FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAA 360

Query: 361 FWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD 420
           FWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD
Sbjct: 361 FWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD 420

Query: 421 KRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQHHH 480
           KRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQHHH
Sbjct: 421 KRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQHHH 480

Query: 481 LLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRI 540
           LLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRI
Sbjct: 481 LLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRI 540

Query: 541 PNANVSGSHQGSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISI 600
           PNANVSGSHQGSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISI
Sbjct: 541 PNANVSGSHQGSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISI 600

Query: 601 PTPPVTTPEGDDRPESPEYSGGNIVRVSAL 630
           PTPPVTTPEGDDRPESPEYSGGNIVRVSAL
Sbjct: 601 PTPPVTTPEGDDRPESPEYSGGNIVRVSAL 630


>gi|27436986 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 2 [Homo sapiens]
          Length = 636

 Score =  970 bits (2508), Expect = 0.0
 Identities = 487/641 (75%), Positives = 556/641 (86%), Gaps = 16/641 (2%)

Query: 1   MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLE 60
           MAAGVAAWLPFARAAAIGWMPVA+ PMP  P  + KR QD LIVLNVSG RFQTW+ TLE
Sbjct: 1   MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKR-QDELIVLNVSGRRFQTWRTTLE 59

Query: 61  RYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELA 120
           RYPDTLLGS+E++FF++ +T++YFFDRDP++FR +LNFYRTGKLHYPR+ECISAYD+ELA
Sbjct: 60  RYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELA 119

Query: 121 FFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGESALPTMTARQRVWRAFENPHT 180
           F+G++PEIIGDCCYEEYKDR+RENAERL DD D++   ES +P+++ RQ +WRAFENPHT
Sbjct: 120 FYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQES-MPSLSFRQTMWRAFENPHT 178

Query: 181 STMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIF 240
           ST+ALVFYYVTGFFIAVSVI NVVETVPCG+ PG  KELPCGERY+VAFFCLDTACVMIF
Sbjct: 179 STLALVFYYVTGFFIAVSVITNVVETVPCGTVPGS-KELPCGERYSVAFFCLDTACVMIF 237

Query: 241 TVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRI 300
           TVEYLLRL AAPSRYRF+RSVMSIIDVVAI+PYYIGLVMT+NEDVSGAFVTLRVFRVFRI
Sbjct: 238 TVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRI 297

Query: 301 FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAA 360
           FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPA+
Sbjct: 298 FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAS 357

Query: 361 FWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD 420
           FWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD
Sbjct: 358 FWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD 417

Query: 421 KRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQ-SSEDEQAFVSKSGSSFETQHH 479
           KRRAQKKARLARIR AK+GS+NAY+ SKRNGLL+  L+ +   E+  + K+ S  E+QHH
Sbjct: 418 KRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHH 477

Query: 480 HLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFR 539
           HLLHCLEKTTNHEF+DEQ+FE++CME +  N PS+ SPSLSS  G+T+TCCSRR KKT  
Sbjct: 478 HLLHCLEKTTNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTH 537

Query: 540 IPNANVSGSHQGSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIIS 599
           +PN+N+  +   S+QELSTI I+  E+  L+ SRSSLN K ++ ++ NC+   +TTAIIS
Sbjct: 538 LPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIIS 597

Query: 600 IPTPPVTTPEGDDRPESPEYSGG----------NIVRVSAL 630
           IPTPP  TPEG+ RP  P  S G          N+V+VSAL
Sbjct: 598 IPTPPALTPEGESRP--PPASPGPNTNIPSIASNVVKVSAL 636


>gi|27436984 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 1 [Homo sapiens]
          Length = 655

 Score =  959 bits (2478), Expect = 0.0
 Identities = 487/660 (73%), Positives = 556/660 (84%), Gaps = 35/660 (5%)

Query: 1   MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLE 60
           MAAGVAAWLPFARAAAIGWMPVA+ PMP  P  + KR QD LIVLNVSG RFQTW+ TLE
Sbjct: 1   MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKR-QDELIVLNVSGRRFQTWRTTLE 59

Query: 61  RYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELA 120
           RYPDTLLGS+E++FF++ +T++YFFDRDP++FR +LNFYRTGKLHYPR+ECISAYD+ELA
Sbjct: 60  RYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELA 119

Query: 121 FFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGESALPTMTARQRVWRAFENPHT 180
           F+G++PEIIGDCCYEEYKDR+RENAERL DD D++   ES +P+++ RQ +WRAFENPHT
Sbjct: 120 FYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQES-MPSLSFRQTMWRAFENPHT 178

Query: 181 STMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIF 240
           ST+ALVFYYVTGFFIAVSVI NVVETVPCG+ PG  KELPCGERY+VAFFCLDTACVMIF
Sbjct: 179 STLALVFYYVTGFFIAVSVITNVVETVPCGTVPGS-KELPCGERYSVAFFCLDTACVMIF 237

Query: 241 TVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRI 300
           TVEYLLRL AAPSRYRF+RSVMSIIDVVAI+PYYIGLVMT+NEDVSGAFVTLRVFRVFRI
Sbjct: 238 TVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRI 297

Query: 301 FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAA 360
           FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPA+
Sbjct: 298 FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAS 357

Query: 361 FWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD 420
           FWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD
Sbjct: 358 FWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD 417

Query: 421 KRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQ-SSEDEQAFVSKSGSSFETQHH 479
           KRRAQKKARLARIR AK+GS+NAY+ SKRNGLL+  L+ +   E+  + K+ S  E+QHH
Sbjct: 418 KRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHH 477

Query: 480 HLLHCLEKTT-------------------NHEFVDEQVFEESCMEVATVNRPSSHSPSLS 520
           HLLHCLEKTT                   NHEF+DEQ+FE++CME +  N PS+ SPSLS
Sbjct: 478 HLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLS 537

Query: 521 SQQGVTSTCCSRRHKKTFRIPNANVSGSHQGSIQELSTIQIRCVERTPLSNSRSSLNAKM 580
           S  G+T+TCCSRR KKT  +PN+N+  +   S+QELSTI I+  E+  L+ SRSSLN K 
Sbjct: 538 SHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKA 597

Query: 581 EECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGG----------NIVRVSAL 630
           ++ ++ NC+   +TTAIISIPTPP  TPEG+ RP  P  S G          N+V+VSAL
Sbjct: 598 DDGLRPNCKTSQITTAIISIPTPPALTPEGESRP--PPASPGPNTNIPSIASNVVKVSAL 655


>gi|27436981 potassium voltage-gated channel, Shal-related
           subfamily, member 1 [Homo sapiens]
          Length = 647

 Score =  828 bits (2140), Expect = 0.0
 Identities = 431/640 (67%), Positives = 513/640 (80%), Gaps = 18/640 (2%)

Query: 1   MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLE 60
           MAAG+A WLPFARAAA+GW+P+A  P+P  P  +  R  + L+V NVSG RF+TW++TL+
Sbjct: 1   MAAGLATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVV-NVSGRRFETWKNTLD 59

Query: 61  RYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELA 120
           RYPDTLLGSSE++FFY  ++ +YFFDRDPD+FRH+LNFYRTG+LH PR ECI A+DEELA
Sbjct: 60  RYPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELA 119

Query: 121 FFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGES-ALPTMTA-RQRVWRAFENP 178
           F+GL+PE++GDCC EEY+DR++ENAERL +D + + AG+  ALP  ++ RQR+WRAFENP
Sbjct: 120 FYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENP 179

Query: 179 HTSTMALVFYYVTGFFIAVSVIANVVETVPC-GSSPGHIKELPCGERYAVAFFCLDTACV 237
           HTST ALVFYYVTGFFIAVSVIANVVET+PC GS+    +E PCGER+  AFFC+DTACV
Sbjct: 180 HTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACV 239

Query: 238 MIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRV 297
           +IFT EYLLRL AAPSR RF+RSVMS+IDVVAILPYYIGL++  N+DVSGAFVTLRVFRV
Sbjct: 240 LIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRV 299

Query: 298 FRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSI 357
           FRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKG++ + FTSI
Sbjct: 300 FRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSI 359

Query: 358 PAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQ 417
           PAAFWYTIVTMTTLGYGDMVP TIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQ
Sbjct: 360 PAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQ 419

Query: 418 RADKRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQ 477
           RADKRRAQ+K RLARIR AKSG+ NA++Q K+NG L +    S +EQA   ++ S+FE Q
Sbjct: 420 RADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLED--SGSGEEQALCVRNRSAFEQQ 477

Query: 478 HHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQ----GVTSTCCSRR 533
           HHHLLHCLEKTT HEF DE  F E+   V+   R +S S S+SSQ      + S+CC RR
Sbjct: 478 HHHLLHCLEKTTCHEFTDELTFSEALGAVSPGGR-TSRSTSVSSQPVGPGSLLSSCCPRR 536

Query: 534 HK-KTFRIPNANVSGSHQGSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPY 592
            K +  R+ N+  S S +GS+QEL    +  + R+    SRSSLNAK  + + LNC+   
Sbjct: 537 AKRRAIRLANSTASVS-RGSMQELD--MLAGLRRSHAPQSRSSLNAKPHDSLDLNCDSRD 593

Query: 593 VTTAIISIPTPPVTTPEGDDRPESPEYSG--GNIVRVSAL 630
              AIISIPTPP  TP+ + +P SP   G  G+ +R S+L
Sbjct: 594 FVAAIISIPTPPANTPD-ESQPSSPGGGGRAGSTLRNSSL 632


>gi|27436974 potassium voltage-gated channel, Shab-related
           subfamily, member 2 [Homo sapiens]
          Length = 911

 Score =  288 bits (737), Expect = 1e-77
 Identities = 185/531 (34%), Positives = 280/531 (52%), Gaps = 49/531 (9%)

Query: 28  PAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHPET------- 80
           P P    R +T    + +NV G   +    TL+R P T LG   RD   H          
Sbjct: 22  PEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKL-RDCNTHESLLEVCDDY 80

Query: 81  ----QQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEE 136
                +YFFDR P  F  ILNFYRTGKLH     C  ++ +EL ++G+    +  CC   
Sbjct: 81  NLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQAR 140

Query: 137 YKDRRRENAERLQDDADT--DTAGESALPTMTA--RQRVWRAFENPHTSTMALVFYYVTG 192
           Y  ++ +  E L+ +A+T  +  GE    T     R+++W   E P++S  A +   V+ 
Sbjct: 141 YHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSI 200

Query: 193 FFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAP 252
            FI +S IA  + T+P         +L    + A     ++  C+  FT+EYLLR  ++P
Sbjct: 201 LFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAH----VEAVCIAWFTMEYLLRFLSSP 256

Query: 253 SRYRFVRSVMSIIDVVAILPYYIGLVMTDN-------EDVSGAFVTLRVFRVFRIFKFSR 305
           ++++F +  +++ID++AILPYY+ + +T++       ++V       R+ R+ RI K +R
Sbjct: 257 NKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLAR 316

Query: 306 HSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTI 365
           HS GL+ LG+TL+   +ELG L+  L M I+IF++++F+AEK   A+KFTSIPA+FW+  
Sbjct: 317 HSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWAT 376

Query: 366 VTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQ 425
           +TMTT+GYGD+ PKT+ GKI G +C ++GVLVIALP+P+IV+NFS  Y + +R +K    
Sbjct: 377 ITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK---A 433

Query: 426 KKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQ----HHHL 481
            K R A  RA ++GS  +        L     +S E     V K+G S  T+     +HL
Sbjct: 434 IKRREALERAKRNGSIVSM------NLKDAFARSMELIDVAVEKAGESANTKDSADDNHL 487

Query: 482 LHCLEKTTN---HEFVDEQVFEESCMEVA------TVNRPSSHSPSLSSQQ 523
                K       E    + FE    EV+       +N  SS SP   S Q
Sbjct: 488 SPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQ 538


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score =  280 bits (716), Expect = 3e-75
 Identities = 159/435 (36%), Positives = 246/435 (56%), Gaps = 30/435 (6%)

Query: 28  PAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHP--------- 78
           P P    R +     + LNV G   +    TL+R P T LG   RD   H          
Sbjct: 18  PEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL-RDCNTHDSLLEVCDDY 76

Query: 79  --ETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEE 136
             +  +YFFDR P  F  ILNFYRTG+LH     C  ++ +EL ++G+    +  CC   
Sbjct: 77  SLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQAR 136

Query: 137 YKDRRRENAERLQDDADT--DTAGESALPTMTA--RQRVWRAFENPHTSTMALVFYYVTG 192
           Y  ++ +  E L+ +A+T  +  GE    T  A  R+++W   E P++S  A +   ++ 
Sbjct: 137 YHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISI 196

Query: 193 FFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAP 252
            FI +S IA  + T+P   S     +     + A     ++  C+  FT+EYLLR  ++P
Sbjct: 197 MFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAH----VEAVCIAWFTMEYLLRFLSSP 252

Query: 253 SRYRFVRSVMSIIDVVAILPYYIGLVMTDN-------EDVSGAFVTLRVFRVFRIFKFSR 305
            +++F +  ++ ID++AILPYY+ + +T++       ++V       R+ R+ RI K +R
Sbjct: 253 KKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLAR 312

Query: 306 HSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTI 365
           HS GL+ LG+TL+   +ELG L+  L M I+IF++++F+AEK    +KF SIPA+FW+  
Sbjct: 313 HSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWAT 372

Query: 366 VTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQ 425
           +TMTT+GYGD+ PKT+ GKI G +C ++GVLVIALP+P+IV+NFS  Y + +R +K    
Sbjct: 373 ITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK---A 429

Query: 426 KKARLARIRAAKSGS 440
            K R A  RA ++GS
Sbjct: 430 IKRREALERAKRNGS 444


>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
           isoform B [Homo sapiens]
          Length = 511

 Score =  273 bits (699), Expect = 3e-73
 Identities = 174/499 (34%), Positives = 261/499 (52%), Gaps = 76/499 (15%)

Query: 43  IVLNVSGTRFQTWQDTLERYPDTLLG-----SSERDFFYHPETQQYFFDRDPDIFRHILN 97
           IV+NV GTR QT++ TL   P T L       +   F Y P   ++FFDR P +F HILN
Sbjct: 10  IVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILN 69

Query: 98  FYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRR-RENA---------ER 147
           +YRTGKLH P   C   Y+EELAF+G+    +  CC+  Y+  R  E A         + 
Sbjct: 70  YYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDN 129

Query: 148 LQDDADTDTAGESALPT----MTAR-------------------QRVWRAFENPHTSTMA 184
             DDAD D  G+S        MT R                    R+W  FE+P++S  A
Sbjct: 130 SADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYA 189

Query: 185 LVFYYVTGFFIAVSVIANVVET---------------VPCGSSPGHIKELPCGERYAVAF 229
               + + FFI VS+    +ET               V  G+   + +E    E  A   
Sbjct: 190 RYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYRE---AETEAFLT 246

Query: 230 FCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI-----GLVMTDNED 284
           + ++  CV+ FT E+L+R+   P++  F+++ ++IID VAILP+Y+     GL     +D
Sbjct: 247 Y-IEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKD 305

Query: 285 VSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFY 344
           V G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFAT+++Y
Sbjct: 306 VLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYY 365

Query: 345 AEK---------GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGV 395
           AE+          S  + F +IP  FW+ +VTMTTLGYGDM P+T +G + G++C+L+GV
Sbjct: 366 AERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGV 425

Query: 396 LVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSAN---AYMQSKRNGL 452
           L IA+PVPVIV+NF   Y       K   +KK  +   R  + GS N   + + S  +  
Sbjct: 426 LTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIP--RPPQLGSPNYCKSVVNSPHHST 483

Query: 453 LSNQLQSSEDEQAFVSKSG 471
            S+    +++E   ++++G
Sbjct: 484 QSDTCPLAQEEILEINRAG 502


>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
           isoform A [Homo sapiens]
          Length = 585

 Score =  272 bits (696), Expect = 6e-73
 Identities = 167/457 (36%), Positives = 242/457 (52%), Gaps = 71/457 (15%)

Query: 43  IVLNVSGTRFQTWQDTLERYPDTLLG-----SSERDFFYHPETQQYFFDRDPDIFRHILN 97
           IV+NV GTR QT++ TL   P T L       +   F Y P   ++FFDR P +F HILN
Sbjct: 10  IVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILN 69

Query: 98  FYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRR-RENA---------ER 147
           +YRTGKLH P   C   Y+EELAF+G+    +  CC+  Y+  R  E A         + 
Sbjct: 70  YYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDN 129

Query: 148 LQDDADTDTAGESALPT----MTAR-------------------QRVWRAFENPHTSTMA 184
             DDAD D  G+S        MT R                    R+W  FE+P++S  A
Sbjct: 130 SADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYA 189

Query: 185 LVFYYVTGFFIAVSVIANVVET---------------VPCGSSPGHIKELPCGERYAVAF 229
               + + FFI VS+    +ET               V  G+   + +E    E  A   
Sbjct: 190 RYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYRE---AETEAFLT 246

Query: 230 FCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI-----GLVMTDNED 284
           + ++  CV+ FT E+L+R+   P++  F+++ ++IID VAILP+Y+     GL     +D
Sbjct: 247 Y-IEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKD 305

Query: 285 VSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFY 344
           V G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFAT+++Y
Sbjct: 306 VLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYY 365

Query: 345 AEK---------GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGV 395
           AE+          S  + F +IP  FW+ +VTMTTLGYGDM P+T +G + G++C+L+GV
Sbjct: 366 AERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGV 425

Query: 396 LVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLAR 432
           L IA+PVPVIV+NF   Y       K   +KK  + R
Sbjct: 426 LTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPR 462


>gi|25952092 potassium voltage-gated channel, shaker-related
           subfamily, member 7 [Homo sapiens]
          Length = 456

 Score =  268 bits (686), Expect = 9e-72
 Identities = 161/415 (38%), Positives = 235/415 (56%), Gaps = 56/415 (13%)

Query: 43  IVLNVSGTRFQTWQDTLERYPDTLLGS-SERDFFYHPETQQYFFDRDPDIFRHILNFYRT 101
           +VLNV+G RF+T   TL R+PDTLLG  + R  FY    ++YFFDR    F  +L +Y++
Sbjct: 15  LVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDRHRPSFDAVLYYYQS 74

Query: 102 G-KLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGES 160
           G +L  P H  +  + EE+AF+GL    +                 RL++D       E 
Sbjct: 75  GGRLRRPAHVPLDVFLEEVAFYGLGAAALA----------------RLREDEGCPVPPER 118

Query: 161 ALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPC----------- 209
            LP     +++W  FE P +S  A V   V+   I VS++   +ET+P            
Sbjct: 119 PLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDGTGLA 178

Query: 210 -------------GSS--PGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSR 254
                        GSS  PG+   LP  +     FF ++T C+  F+ E L+RL   PS+
Sbjct: 179 AAAAAGPFPAPLNGSSQMPGNPPRLPFND----PFFVVETLCICWFSFELLVRLLVCPSK 234

Query: 255 YRFVRSVMSIIDVVAILPYYIGLVM-------TDNEDVSGAFV-TLRVFRVFRIFKFSRH 306
             F ++VM++ID VAILPY++ L            + +S A +  +R+ RVFRIFK SRH
Sbjct: 235 AIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMSLAILRVIRLVRVFRIFKLSRH 294

Query: 307 SQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIV 366
           S+GL+ILG TL++   ELG L+F L + +++F++ +++AE     S FTSIP +FW+ +V
Sbjct: 295 SKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSHFTSIPESFWWAVV 354

Query: 367 TMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADK 421
           TMTT+GYGDM P T+ GKI GS+C+++GVL I+LPVPVIVSNFS  YH+    ++
Sbjct: 355 TMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEE 409


>gi|4826782 potassium voltage-gated channel, shaker-related
           subfamily, member 2 [Homo sapiens]
          Length = 499

 Score =  264 bits (675), Expect = 2e-70
 Identities = 162/477 (33%), Positives = 269/477 (56%), Gaps = 50/477 (10%)

Query: 43  IVLNVSGTRFQTWQDTLERYPDTLLGS-SERDFFYHPETQQYFFDRDPDIFRHILNFYRT 101
           +V+N+SG RF+T   TL ++P+TLLG   +R  ++ P   +YFFDR+   F  IL +Y++
Sbjct: 35  VVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQS 94

Query: 102 -GKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGES 160
            G+L  P +  +  + EE+ F+ L          EE  +  RE+   ++++       E 
Sbjct: 95  GGRLRRPVNVPLDIFSEEIRFYEL---------GEEAMEMFREDEGYIKEE-------ER 138

Query: 161 ALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVP-----------C 209
            LP    +++VW  FE P +S  A +   V+   I +S+++  +ET+P            
Sbjct: 139 PLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGS 198

Query: 210 GSSPGHIKELPCGERYAVA----FFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSII 265
           G +         G + + +    FF ++T C++ F+ E+L+R  A PS+  F  ++M+II
Sbjct: 199 GVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNII 258

Query: 266 DVVAILPYYIGL----------VMTDNEDVSGAFV-TLRVFRVFRIFKFSRHSQGLRILG 314
           D+VAI+PY+I L               + +S A +  +R+ RVFRIFK SRHS+GL+ILG
Sbjct: 259 DIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILG 318

Query: 315 YTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYG 374
            TLK+   ELG L+F L + +I+F++ +++AE     S+F SIP AFW+ +V+MTT+GYG
Sbjct: 319 QTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYG 378

Query: 375 DMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIR 434
           DMVP TI GKI GS+C+++GVL IALPVPVIVSNF+  YH+     +   +++A+  ++ 
Sbjct: 379 DMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHR-----ETEGEEQAQYLQVT 433

Query: 435 AAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQHHHLLHCLEKTTNH 491
           +     ++  ++  R+    ++    E ++  V+ S   F  ++    +C    TN+
Sbjct: 434 SCPKIPSSPDLKKSRSASTISKSDYMEIQEG-VNNSNEDFREENLKTANCTLANTNY 489


>gi|88758565 potassium voltage-gated channel, shaker-related
           subfamily, member 3 [Homo sapiens]
          Length = 575

 Score =  262 bits (669), Expect = 8e-70
 Identities = 164/468 (35%), Positives = 257/468 (54%), Gaps = 61/468 (13%)

Query: 28  PAPPRQERKRTQDAL---IVLNVSGTRFQTWQDTLERYPDTLLGSSERDF-FYHPETQQY 83
           P PP       QD     +V+N+SG RF+T   TL ++P+TLLG  +R   ++ P   +Y
Sbjct: 88  PLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEY 147

Query: 84  FFDRDPDIFRHILNFYRTG-KLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRR 142
           FFDR+   F  IL +Y++G ++  P +  I  + EE+ F+ L          EE  ++ R
Sbjct: 148 FFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQL---------GEEAMEKFR 198

Query: 143 ENAERLQDDADTDTAGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIAN 202
           E+   L+++       E  LP    +++VW  FE P +S  A     V+   I +S++  
Sbjct: 199 EDEGFLREE-------ERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIF 251

Query: 203 VVETVP-------------------CGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVE 243
            +ET+P                    G+S    +       ++  FF ++T C++ F+ E
Sbjct: 252 CLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRA--GASSFSDPFFVVETLCIIWFSFE 309

Query: 244 YLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI--GLVMTDNEDVSGAFVTL------RVF 295
            L+R  A PS+  F R++M++ID+VAI+PY+I  G  + + +      ++L      R+ 
Sbjct: 310 LLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLV 369

Query: 296 RVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFT 355
           RVFRIFK SRHS+GL+ILG TLK+   ELG L+F L + +I+F++ +++AE     S F+
Sbjct: 370 RVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFS 429

Query: 356 SIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQ 415
           SIP AFW+ +VTMTT+GYGDM P TI GKI GS+C+++GVL IALPVPVIVSNF+  YH+
Sbjct: 430 SIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHR 489

Query: 416 NQRADKRR-----------AQKKARLARIRAAKSGSANAYMQSKRNGL 452
               +++            +     L + R+  + S + YM  +  G+
Sbjct: 490 ETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGM 537


>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
           isoform c [Homo sapiens]
          Length = 626

 Score =  261 bits (667), Expect = 1e-69
 Identities = 182/590 (30%), Positives = 285/590 (48%), Gaps = 113/590 (19%)

Query: 43  IVLNVSGTRFQTWQDTLERYPDTLLG-SSERDFFYHPETQ---------------QYFFD 86
           I++NV GTR +T++ TL   P T L   ++ D    PET                ++FFD
Sbjct: 38  IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFD 97

Query: 87  RDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAE 146
           R P +F ++LN+YRTGKLH P   C   ++EEL F+G+    +  CC+  Y+ + R+  E
Sbjct: 98  RHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYR-QHRDAEE 156

Query: 147 RLQDDADTDTAGESALPTMTA-------------------------------RQRVWRAF 175
            L      D  G  A P+  A                               + R+W  F
Sbjct: 157 ALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALF 216

Query: 176 ENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKE-LPCGERYAVAF----- 229
           E+P++S  A V  + + FFI VS+    +ET    +   ++ E L  G   +V F     
Sbjct: 217 EDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVE 276

Query: 230 -----FCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI-----GLVM 279
                  ++  CV+ FT+E+L+R+   P    FV+++++IID VAILP+Y+     GL  
Sbjct: 277 TEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSS 336

Query: 280 TDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339
               DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFA
Sbjct: 337 KAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 396

Query: 340 TVMFYAEK---------GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 390
           T+++YAE+         G+  + F +IP  FW+ +VTMTTLGYGDM PKT +G + G++C
Sbjct: 397 TMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALC 456

Query: 391 SLSGVLVIALPVPVIVSNFSRIYH---QNQRADKRR------------------------ 423
           +L+GVL IA+PVPVIV+NF   Y      Q+  K+R                        
Sbjct: 457 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPR 516

Query: 424 ----------AQKKARLARIRA--AKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSG 471
                     A+++  + R RA   ++G ANA +  +    L+  L SS   +   +   
Sbjct: 517 DSTCSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRR 576

Query: 472 SSFETQHHHLLHC-LEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLS 520
           S+   ++     C L  T ++   D  V +E+C +  + N   +   +LS
Sbjct: 577 STTRDRNKKAAACFLLSTGDYACADGSVRKETCQDALSSNYAQAEVLTLS 626


>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
           isoform a [Homo sapiens]
          Length = 635

 Score =  259 bits (663), Expect = 4e-69
 Identities = 161/468 (34%), Positives = 246/468 (52%), Gaps = 76/468 (16%)

Query: 43  IVLNVSGTRFQTWQDTLERYPDTLLG-SSERDFFYHPETQ---------------QYFFD 86
           I++NV GTR +T++ TL   P T L   ++ D    PET                ++FFD
Sbjct: 38  IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFD 97

Query: 87  RDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAE 146
           R P +F ++LN+YRTGKLH P   C   ++EEL F+G+    +  CC+  Y+ + R+  E
Sbjct: 98  RHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYR-QHRDAEE 156

Query: 147 RLQDDADTDTAGESALPTMTA-------------------------------RQRVWRAF 175
            L      D  G  A P+  A                               + R+W  F
Sbjct: 157 ALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALF 216

Query: 176 ENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKE-LPCGERYAVAF----- 229
           E+P++S  A V  + + FFI VS+    +ET    +   ++ E L  G   +V F     
Sbjct: 217 EDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVE 276

Query: 230 -----FCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI-----GLVM 279
                  ++  CV+ FT+E+L+R+   P    FV+++++IID VAILP+Y+     GL  
Sbjct: 277 TEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSS 336

Query: 280 TDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339
               DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFA
Sbjct: 337 KAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 396

Query: 340 TVMFYAEK---------GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 390
           T+++YAE+         G+  + F +IP  FW+ +VTMTTLGYGDM PKT +G + G++C
Sbjct: 397 TMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALC 456

Query: 391 SLSGVLVIALPVPVIVSNFSRIYH---QNQRADKRRAQKKARLARIRA 435
           +L+GVL IA+PVPVIV+NF   Y      Q+  K+R +   R A++ +
Sbjct: 457 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLES 504


>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
           isoform b [Homo sapiens]
          Length = 582

 Score =  259 bits (663), Expect = 4e-69
 Identities = 161/468 (34%), Positives = 246/468 (52%), Gaps = 76/468 (16%)

Query: 43  IVLNVSGTRFQTWQDTLERYPDTLLG-SSERDFFYHPETQ---------------QYFFD 86
           I++NV GTR +T++ TL   P T L   ++ D    PET                ++FFD
Sbjct: 38  IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFD 97

Query: 87  RDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAE 146
           R P +F ++LN+YRTGKLH P   C   ++EEL F+G+    +  CC+  Y+ + R+  E
Sbjct: 98  RHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYR-QHRDAEE 156

Query: 147 RLQDDADTDTAGESALPTMTA-------------------------------RQRVWRAF 175
            L      D  G  A P+  A                               + R+W  F
Sbjct: 157 ALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALF 216

Query: 176 ENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKE-LPCGERYAVAF----- 229
           E+P++S  A V  + + FFI VS+    +ET    +   ++ E L  G   +V F     
Sbjct: 217 EDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVE 276

Query: 230 -----FCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI-----GLVM 279
                  ++  CV+ FT+E+L+R+   P    FV+++++IID VAILP+Y+     GL  
Sbjct: 277 TEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSS 336

Query: 280 TDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339
               DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFA
Sbjct: 337 KAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 396

Query: 340 TVMFYAEK---------GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 390
           T+++YAE+         G+  + F +IP  FW+ +VTMTTLGYGDM PKT +G + G++C
Sbjct: 397 TMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALC 456

Query: 391 SLSGVLVIALPVPVIVSNFSRIYH---QNQRADKRRAQKKARLARIRA 435
           +L+GVL IA+PVPVIV+NF   Y      Q+  K+R +   R A++ +
Sbjct: 457 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLES 504


>gi|119395748 potassium voltage-gated channel subfamily A member 1
           [Homo sapiens]
          Length = 495

 Score =  258 bits (658), Expect = 2e-68
 Identities = 149/402 (37%), Positives = 238/402 (59%), Gaps = 38/402 (9%)

Query: 43  IVLNVSGTRFQTWQDTLERYPDTLLGSSERDF-FYHPETQQYFFDRDPDIFRHILNFYRT 101
           +V+N+SG RF+T   TL ++P+TLLG+ ++   ++ P   +YFFDR+   F  IL +Y++
Sbjct: 39  VVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQS 98

Query: 102 G-KLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGES 160
           G +L  P +  +  + EE+ F+ L          EE  ++ RE+   ++++       E 
Sbjct: 99  GGRLRRPVNVPLDMFSEEIKFYEL---------GEEAMEKFREDEGFIKEE-------ER 142

Query: 161 ALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVP----CGSSPGHI 216
            LP    +++VW  FE P +S  A V   V+   I +S++   +ET+P         G +
Sbjct: 143 PLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTV 202

Query: 217 KELPC------GERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAI 270
             +           +   FF ++T C++ F+ E ++R  A PS+  F +++M+ ID+VAI
Sbjct: 203 HRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAI 262

Query: 271 LPYYIGL---VMTDNEDVSGAFVT-------LRVFRVFRIFKFSRHSQGLRILGYTLKSC 320
           +PY+I L   +     +  G   T       +R+ RVFRIFK SRHS+GL+ILG TLK+ 
Sbjct: 263 IPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKAS 322

Query: 321 ASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKT 380
             ELG L+F L + +I+F++ +++AE   + S F+SIP AFW+ +V+MTT+GYGDM P T
Sbjct: 323 MRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVT 382

Query: 381 IAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 422
           I GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 383 IGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQ 424


>gi|4504817 potassium voltage-gated channel, shaker-related
           subfamily, member 4 [Homo sapiens]
          Length = 653

 Score =  257 bits (656), Expect = 3e-68
 Identities = 153/414 (36%), Positives = 236/414 (57%), Gaps = 49/414 (11%)

Query: 43  IVLNVSGTRFQTWQDTLERYPDTLLGSSE-RDFFYHPETQQYFFDRDPDIFRHILNFYRT 101
           +V+NVSG RF+T   TL ++P+TLLG  E R  ++ P   +YFFDR+   F  IL +Y++
Sbjct: 178 VVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQS 237

Query: 102 G-KLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGES 160
           G +L  P +     + EE+ F+ L  E +        K R  E   R ++D         
Sbjct: 238 GGRLKRPVNVPFDIFTEEVKFYQLGEEAL-------LKFREDEGFVREEEDR-------- 282

Query: 161 ALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVP------------ 208
           ALP    ++++W  FE P +S+ A     V+   I +S++   +ET+P            
Sbjct: 283 ALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMAL 342

Query: 209 -CGSSPGHIKELPCGER-------YAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRS 260
             G   G + +             +   FF ++T C++ F+ E+++R  A PS+  F ++
Sbjct: 343 SAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKN 402

Query: 261 VMSIIDVVAILPYYIGLVMTDNEDVSG---------AFVTLRVFR---VFRIFKFSRHSQ 308
           +M+IID+V+ILPY+I L     +   G         +F  LR+ R   VFRIFK SRHS+
Sbjct: 403 IMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSK 462

Query: 309 GLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTM 368
           GL+ILG+TL++   ELG L+F L + +I+F++ +++AE     + F SIP AFW+ +VTM
Sbjct: 463 GLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTM 522

Query: 369 TTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 422
           TT+GYGDM P T+ GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 523 TTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQ 576


>gi|5031819 potassium voltage-gated channel, shaker-related
           subfamily, member 10 [Homo sapiens]
          Length = 511

 Score =  256 bits (655), Expect = 3e-68
 Identities = 148/421 (35%), Positives = 242/421 (57%), Gaps = 43/421 (10%)

Query: 25  GPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSSERDF-FYHPETQQY 83
           GP P    +  +R     +++N++G RF+T   TL ++P+TLLG  E+   F+     +Y
Sbjct: 75  GPEPVVLNEGNQR-----VIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEY 129

Query: 84  FFDRDPDIFRHILNFYRTG-KLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRR 142
           FFDR+   F  IL +Y++G K+  P +  I  + +E++F+ L  E +         D+ R
Sbjct: 130 FFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAM---------DQFR 180

Query: 143 ENAERLQDDADTDTAGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIAN 202
           E+   ++D        E+ LPT    ++ W  FE P +S+ A     V+   + +S+   
Sbjct: 181 EDEGFIKDP-------ETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIF 233

Query: 203 VVETVPCGSSPGHIKELP-----------CGERYAVAFFCLDTACVMIFTVEYLLRLAAA 251
            +ET+P       +K +                +   FF +++ C++ FT E +LR    
Sbjct: 234 CLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVC 293

Query: 252 PSRYRFVRSVMSIIDVVAILPYYIGLVM--------TDNEDVSGAFVTL-RVFRVFRIFK 302
           PS+  F R++M+IID+++I+PY+  L+         +  +++S A + + R+ RVFRIFK
Sbjct: 294 PSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFK 353

Query: 303 FSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFW 362
            SRHS+GL+ILG TLK+   ELG L+F L + +I+F++ +++AE     S F+SIP  FW
Sbjct: 354 LSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFW 413

Query: 363 YTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 422
           + +VTMTT+GYGDM P T  GKI G++C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 414 WAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEK 473

Query: 423 R 423
           +
Sbjct: 474 Q 474


>gi|25952087 potassium voltage-gated channel, shaker-related
           subfamily, member 5 [Homo sapiens]
          Length = 613

 Score =  254 bits (650), Expect = 1e-67
 Identities = 156/418 (37%), Positives = 232/418 (55%), Gaps = 63/418 (15%)

Query: 45  LNVSGTRFQTWQDTLERYPDTLLGS-SERDFFYHPETQQYFFDRDPDIFRHILNFYRTG- 102
           +N+SG RF+T   TL ++P+TLLG  ++R  ++ P   +YFFDR+   F  IL +Y++G 
Sbjct: 124 INISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGG 183

Query: 103 KLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGESAL 162
           +L  P +  +  + +E+ F+ L     GD           E  ER ++D       E  L
Sbjct: 184 RLRRPVNVSLDVFADEIRFYQL-----GD-----------EAMERFREDEGFIKEEEKPL 227

Query: 163 PTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVP-------------- 208
           P    +++VW  FE P +S  A     V+   I +S+I   +ET+P              
Sbjct: 228 PRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPA 287

Query: 209 --------CGSSPGHIKELPCGERYAVA--------FFCLDTACVMIFTVEYLLRLAAAP 252
                    G++   +   P G   A          FF ++T CV+ FT E L+R  A P
Sbjct: 288 PHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACP 347

Query: 253 SRYRFVRSVMSIIDVVAILPYYI--GLVMTDNEDVSGA-------------FVTLRVFRV 297
           S+  F R++M+IIDVVAI PY+I  G  + + +   G                 +R+ RV
Sbjct: 348 SKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRV 407

Query: 298 FRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSI 357
           FRIFK SRHS+GL+ILG TL++   ELG L+F L + +I+F++ +++AE  +  + F+SI
Sbjct: 408 FRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSI 467

Query: 358 PAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQ 415
           P AFW+ +VTMTT+GYGDM P T+ GKI GS+C+++GVL IALPVPVIVSNF+  YH+
Sbjct: 468 PDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHR 525


>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
           [Homo sapiens]
          Length = 757

 Score =  253 bits (646), Expect = 4e-67
 Identities = 165/489 (33%), Positives = 248/489 (50%), Gaps = 94/489 (19%)

Query: 43  IVLNVSGTRFQTWQDTLERYPDT-LLGSSERD----FFYHPETQQYFFDRDPDIFRHILN 97
           IV+NV G R +T++ TL   P T L G +E +    F Y P   ++FFDR P +F ++LN
Sbjct: 90  IVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLN 149

Query: 98  FYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRR---------------- 141
           +YRTGKLH P   C   ++EEL F+G+    +  CC+  Y+  R                
Sbjct: 150 YYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAG 209

Query: 142 RENAER--------LQDDADT------------------DTAGESALPTMTA-------- 167
             NA          L D+A                    D  G +  P   A        
Sbjct: 210 AANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWW 269

Query: 168 ---RQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVET-----------------V 207
              + RVW  FE+P++S  A    + + FFI +S+    +ET                 +
Sbjct: 270 RRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPI 329

Query: 208 PCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDV 267
           P G+ P +I  +       + +  ++  CV+ FT E+L+R+   P +  F++S ++IID 
Sbjct: 330 P-GAPPENITNVEVETEPFLTY--VEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDC 386

Query: 268 VAILPYYI-----GLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 322
           VAILP+Y+     GL     +DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +
Sbjct: 387 VAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTN 446

Query: 323 ELGFLLFSLTMAIIIFATVMFYAEK---------GSSASKFTSIPAAFWYTIVTMTTLGY 373
           E   L+  L + ++IFAT+++YAE+         GS+ + F +IP  FW+ +VTMTTLGY
Sbjct: 447 EFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGY 506

Query: 374 GDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARI 433
           GDM PKT +G + G++C+L+GVL IA+PVPVIV+NF   Y  +    K++  KK      
Sbjct: 507 GDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY--SLAMAKQKLPKKKNKHIP 564

Query: 434 RAAKSGSAN 442
           R  + GS N
Sbjct: 565 RPPQPGSPN 573


>gi|4504821 potassium voltage-gated channel, shaker-related
           subfamily, member 6 [Homo sapiens]
          Length = 529

 Score =  247 bits (631), Expect = 2e-65
 Identities = 157/445 (35%), Positives = 234/445 (52%), Gaps = 78/445 (17%)

Query: 43  IVLNVSGTRFQTWQDTLERYPDTLLGSSERDF-FYHPETQQYFFDRDPDIFRHILNFYRT 101
           +V+N+SG RF+T   TL  +PDTLLG   R   F+ P   +YFFDR+   F  IL +Y++
Sbjct: 43  LVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQS 102

Query: 102 G-KLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGES 160
           G +L  P +  +  + EE+ F+ L  E +    + E +    E  E            E 
Sbjct: 103 GGRLRRPVNVPLDIFLEEIRFYQLGDEALA--AFREDEGCLPEGGE-----------DEK 149

Query: 161 ALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPC-------GSSP 213
            LP+   +++VW  FE P +S  A     V+   I +S++   +ET+P        G++ 
Sbjct: 150 PLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNG 209

Query: 214 GHIKELPC--------------------------------------GERYAVAFFCLDTA 235
           G  +  P                                       G  +   FF ++T 
Sbjct: 210 GVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETL 269

Query: 236 CVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGL-----VMTDNEDVSGA-- 288
           C++ FT E L+R +A PS+  F R++M+IID+VAI PY+I L        + +  SG   
Sbjct: 270 CIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGG 329

Query: 289 -----------FVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIII 337
                         +R+ RVFRIFK SRHS+GL+ILG TL++   ELG L+F L + +I+
Sbjct: 330 QNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVIL 389

Query: 338 FATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLV 397
           F++ +++AE     S F SIP AFW+ +VTMTT+GYGDM P T+ GKI GS+C+++GVL 
Sbjct: 390 FSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLT 449

Query: 398 IALPVPVIVSNFSRIYHQNQRADKR 422
           IALPVPVIVSNF+  YH+    +++
Sbjct: 450 IALPVPVIVSNFNYFYHRETEQEEQ 474


>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
           [Homo sapiens]
          Length = 494

 Score =  243 bits (619), Expect = 5e-64
 Identities = 151/441 (34%), Positives = 233/441 (52%), Gaps = 39/441 (8%)

Query: 27  MPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDT--------LLGSSERDFF--- 75
           +P P  Q    + D  IV+NV G R   + D L +YP+T        L G  +  F    
Sbjct: 9   LPEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCD 68

Query: 76  -YHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCY 134
            Y P  ++++FDRDPD F+ ++  Y  G++H  +  C   +  E+ F+ +  + + DCC 
Sbjct: 69  DYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCK 128

Query: 135 EEYKDRRRENAE---RLQ---DDADTDTAGESALPTMTARQRVWRAFENPHTSTMALVFY 188
               ++R E  E   R+Q   DD   D A          ++ VW+  E P +S  A V  
Sbjct: 129 SHLSEKREELEEIARRVQLILDDLGVDAAEGR---WRRCQKCVWKFLEKPESSCPARVVA 185

Query: 189 YVTGFFIAVSVIANVVETVP---CGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYL 245
            ++   I VS +   + T+P      + G+  E P  E        ++TAC+  FT+EYL
Sbjct: 186 VLSFLLILVSSVVMCMGTIPELQVLDAEGNRVEHPTLEN-------VETACIGWFTLEYL 238

Query: 246 LRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMT-------DNEDVSGAFVTLRVFRVF 298
           LRL ++P++  F  S M+I+DV+AILP+Y+ L +T       +  +V  A   LR+ R+ 
Sbjct: 239 LRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIA 298

Query: 299 RIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIP 358
           RIFK +RHS GL+ L Y LK    ELG LL  L + I +F+ + +  E+    + F SIP
Sbjct: 299 RIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIP 358

Query: 359 AAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQR 418
            +FW+ I+TMTT+GYGD+ PKT  GK+  +I  L GV+ IALP+  I++NF R Y+  QR
Sbjct: 359 QSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVR-YYNKQR 417

Query: 419 ADKRRAQKKARLARIRAAKSG 439
             +  A+ +  L  + ++  G
Sbjct: 418 VLETAAKHELELMELNSSSGG 438


>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2a [Homo sapiens]
          Length = 613

 Score =  241 bits (614), Expect = 2e-63
 Identities = 146/429 (34%), Positives = 235/429 (54%), Gaps = 56/429 (13%)

Query: 81  QQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDR 140
           +++FFDR P +F ++LN+YRTGKLH P   C   ++EELAF+G+    +  CC+  Y+  
Sbjct: 100 REFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159

Query: 141 RRENAERLQDDADT----------------------DTAGESALPTMTAR-----QRVWR 173
           R  +AE   D  +T                      D AG       + R      R+W 
Sbjct: 160 R--DAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWA 217

Query: 174 AFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLD 233
            FE+P++S  A    + + FFI VS+    +ET    +   +  E        V  + ++
Sbjct: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIE 277

Query: 234 T---------ACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI-----GLVM 279
           T          CV+ FT E+L+R+  +P++  F++++++IID VAILP+Y+     GL  
Sbjct: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSS 337

Query: 280 TDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339
              +DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFA
Sbjct: 338 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 397

Query: 340 TVMFYAEK---------GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 390
           T+++YAE+          S  ++F +IP  FW+ +VTMTTLGYGDM P+T +G + G++C
Sbjct: 398 TMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 457

Query: 391 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRN 450
           +L+GVL IA+PVPVIV+NF  +Y+    A ++  +K+ +   I  A   S+  + +++ N
Sbjct: 458 ALAGVLTIAMPVPVIVNNFG-MYYSLAMAKQKLPRKRKK--HIPPAPQASSPTFCKTELN 514

Query: 451 GLLSNQLQS 459
            +  N  QS
Sbjct: 515 -MACNSTQS 522



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 16/32 (50%), Positives = 22/32 (68%), Gaps = 3/32 (9%)

Query: 43 IVLNVSGTRFQTWQDTLERYPDT---LLGSSE 71
          ++LNV GTR +T++ TL+  P T   LL SSE
Sbjct: 10 VILNVGGTRHETYRSTLKTLPGTRLALLASSE 41


>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2b [Homo sapiens]
          Length = 638

 Score =  241 bits (614), Expect = 2e-63
 Identities = 146/429 (34%), Positives = 235/429 (54%), Gaps = 56/429 (13%)

Query: 81  QQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDR 140
           +++FFDR P +F ++LN+YRTGKLH P   C   ++EELAF+G+    +  CC+  Y+  
Sbjct: 100 REFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159

Query: 141 RRENAERLQDDADT----------------------DTAGESALPTMTAR-----QRVWR 173
           R  +AE   D  +T                      D AG       + R      R+W 
Sbjct: 160 R--DAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWA 217

Query: 174 AFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLD 233
            FE+P++S  A    + + FFI VS+    +ET    +   +  E        V  + ++
Sbjct: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIE 277

Query: 234 T---------ACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI-----GLVM 279
           T          CV+ FT E+L+R+  +P++  F++++++IID VAILP+Y+     GL  
Sbjct: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSS 337

Query: 280 TDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339
              +DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFA
Sbjct: 338 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 397

Query: 340 TVMFYAEK---------GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 390
           T+++YAE+          S  ++F +IP  FW+ +VTMTTLGYGDM P+T +G + G++C
Sbjct: 398 TMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 457

Query: 391 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRN 450
           +L+GVL IA+PVPVIV+NF  +Y+    A ++  +K+ +   I  A   S+  + +++ N
Sbjct: 458 ALAGVLTIAMPVPVIVNNFG-MYYSLAMAKQKLPRKRKK--HIPPAPQASSPTFCKTELN 514

Query: 451 GLLSNQLQS 459
            +  N  QS
Sbjct: 515 -MACNSTQS 522



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 16/32 (50%), Positives = 22/32 (68%), Gaps = 3/32 (9%)

Query: 43 IVLNVSGTRFQTWQDTLERYPDT---LLGSSE 71
          ++LNV GTR +T++ TL+  P T   LL SSE
Sbjct: 10 VILNVGGTRHETYRSTLKTLPGTRLALLASSE 41


>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2c [Homo sapiens]
          Length = 558

 Score =  241 bits (614), Expect = 2e-63
 Identities = 146/429 (34%), Positives = 235/429 (54%), Gaps = 56/429 (13%)

Query: 81  QQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDR 140
           +++FFDR P +F ++LN+YRTGKLH P   C   ++EELAF+G+    +  CC+  Y+  
Sbjct: 100 REFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159

Query: 141 RRENAERLQDDADT----------------------DTAGESALPTMTAR-----QRVWR 173
           R  +AE   D  +T                      D AG       + R      R+W 
Sbjct: 160 R--DAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWA 217

Query: 174 AFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLD 233
            FE+P++S  A    + + FFI VS+    +ET    +   +  E        V  + ++
Sbjct: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIE 277

Query: 234 T---------ACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI-----GLVM 279
           T          CV+ FT E+L+R+  +P++  F++++++IID VAILP+Y+     GL  
Sbjct: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSS 337

Query: 280 TDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339
              +DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFA
Sbjct: 338 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 397

Query: 340 TVMFYAEK---------GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 390
           T+++YAE+          S  ++F +IP  FW+ +VTMTTLGYGDM P+T +G + G++C
Sbjct: 398 TMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 457

Query: 391 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRN 450
           +L+GVL IA+PVPVIV+NF  +Y+    A ++  +K+ +   I  A   S+  + +++ N
Sbjct: 458 ALAGVLTIAMPVPVIVNNFG-MYYSLAMAKQKLPRKRKK--HIPPAPQASSPTFCKTELN 514

Query: 451 GLLSNQLQS 459
            +  N  QS
Sbjct: 515 -MACNSTQS 522



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 16/32 (50%), Positives = 22/32 (68%), Gaps = 3/32 (9%)

Query: 43 IVLNVSGTRFQTWQDTLERYPDT---LLGSSE 71
          ++LNV GTR +T++ TL+  P T   LL SSE
Sbjct: 10 VILNVGGTRHETYRSTLKTLPGTRLALLASSE 41


>gi|25952108 potassium voltage-gated channel delayed-rectifier
           protein S3 [Homo sapiens]
          Length = 491

 Score =  236 bits (603), Expect = 4e-62
 Identities = 144/429 (33%), Positives = 227/429 (52%), Gaps = 44/429 (10%)

Query: 35  RKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGS-----SERDFF-----YHPETQQYF 84
           R    + L+ LNV G +    Q TL R+P T LG      SE         Y    ++Y+
Sbjct: 9   RPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYY 68

Query: 85  FDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRREN 144
           FDR+P +FR++LNFY TGKLH     C+ ++ +E+ ++G+    I  CC   Y++R+ EN
Sbjct: 69  FDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEEN 128

Query: 145 AERLQDDADTDTAGESALPTMTA----------------RQRVWRAFENPHTSTMALVFY 188
            E+  D    D + +S+    +                 R+++W   ENP         Y
Sbjct: 129 HEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPA--------Y 180

Query: 189 YVTGFFIAVSVIANVVETVP--CGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLL 246
            ++   IA+S ++ V+ ++   C  S    +    GE        ++ AC+  FT E  +
Sbjct: 181 CLSAKLIAISSLSVVLASIVAMCVHSMSEFQNED-GEVDDPVLEGVEIACIAWFTGELAV 239

Query: 247 RLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVS------GAFVT-LRVFRVFR 299
           RLAAAP + +F ++ ++IID V+I+P+Y  L +   E+ S      G  V  LR+ R+FR
Sbjct: 240 RLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFR 299

Query: 300 IFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPA 359
           I K +RHS GLR LG TL+    E+G LL  L++ I IF+ +++  EK    S  TSIP 
Sbjct: 300 ILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPI 359

Query: 360 AFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRA 419
            +W+  ++MTT+GYGD  P T+AGK+  S C + G+LV+ALP+ +I + FS+ Y + +  
Sbjct: 360 CWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDI 419

Query: 420 DKRRAQKKA 428
           D  +  + A
Sbjct: 420 DVDQCSEDA 428


>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
          Length = 500

 Score =  231 bits (590), Expect = 1e-60
 Identities = 143/421 (33%), Positives = 217/421 (51%), Gaps = 50/421 (11%)

Query: 45  LNVSGTRFQTWQDTLERYPDTLLGSS--------------------ERDFFYHPETQQYF 84
           +NV G+RF   Q  L  +P T LG                      E     +P   +YF
Sbjct: 43  VNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYF 102

Query: 85  FDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRREN 144
           FDR    FR++L++YRTG+LH     C  ++ +E+ ++G+    I  CC + Y  RR+E 
Sbjct: 103 FDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYF-RRKEL 161

Query: 145 AERL---QDDADTDTAGESAL-----PTMTARQRVWRAFENPHTSTMALVFYYVTGFFIA 196
           +E L   +D  D ++  ES       P  T RQ++W   E P +ST A +F  ++  F+ 
Sbjct: 162 SETLDFKKDTEDQESQHESEQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVV 221

Query: 197 VSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYR 256
           VS+I   + +         + E+            L+  C+  FT E++LR      R R
Sbjct: 222 VSIINMALMSAELSWLDLQLLEI------------LEYVCISWFTGEFVLRFLCVRDRCR 269

Query: 257 FVRSVMSIIDVVAILPYYIGLVMT---------DNEDVSGAFVTLRVFRVFRIFKFSRHS 307
           F+R V +IID++AILP+YI L++          + E+V      LR+ R  R+ K  RHS
Sbjct: 270 FLRKVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHS 329

Query: 308 QGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVT 367
            GLR LG T+  C  E+G LL  L++ I IF+TV ++AE+    + FTS+P A+W+   +
Sbjct: 330 TGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTS 389

Query: 368 MTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKK 427
           MTT+GYGD+ P T  GKI   +C LSG+LV+ALP+ +I   FS  Y   +  +    Q++
Sbjct: 390 MTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQRE 449

Query: 428 A 428
           A
Sbjct: 450 A 450


>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
           [Homo sapiens]
          Length = 513

 Score =  224 bits (570), Expect = 2e-58
 Identities = 148/437 (33%), Positives = 223/437 (51%), Gaps = 53/437 (12%)

Query: 31  PRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSSER-----DFF-----YHPET 80
           P   R+R     I++NV G ++     TL+ +P T LG  +      D       Y    
Sbjct: 58  PEDRRRR-----IIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTC 112

Query: 81  QQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDR 140
            ++FFDR+P  F  IL F R GKL   R  C  ++ EEL ++G+  + +  CC   Y  +
Sbjct: 113 NEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQK 172

Query: 141 RRENAE---RLQDDADTDTAGESALPTMTARQRVWRAF-------ENPHTSTMALVFYYV 190
             E AE   R ++D   D+ G  +        R+ R         E PH+     VF  +
Sbjct: 173 IEEFAEMVEREEEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACL 232

Query: 191 TGFFIAVSVIANVVETVPC---GSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLR 247
           +  F+ V+ +   V T+P        GH  ++ C        F +++ CV  F++E+LLR
Sbjct: 233 SVLFVTVTAVNLSVSTLPSLREEEEQGHCSQM-CHN-----VFIVESVCVGWFSLEFLLR 286

Query: 248 LAAAPSRYRFVRSVMSIIDVVAILPYYIGLVM-----------TDNEDVSGAFVTLRVFR 296
           L  APS++ F+RS +++ID+VAILPYYI L++             N  +    + LRV R
Sbjct: 287 LIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLR 346

Query: 297 VFRIF---KFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSAS- 352
             RI    + +RHS GL+ LG T + C  E G LL  L +AI +FA +++  E   + S 
Sbjct: 347 ALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSP 406

Query: 353 KFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRI 412
           +FTSIPA +W+ ++TMTT+GYGDMVP++  G++      LSG+L++A PV  I   FSR 
Sbjct: 407 EFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRS 466

Query: 413 Y----HQNQRADKRRAQ 425
           Y     + +R   RRAQ
Sbjct: 467 YLELKQEQERVMFRRAQ 483


>gi|13492973 potassium voltage-gated channel delayed-rectifier
           protein S1 [Homo sapiens]
          Length = 526

 Score =  216 bits (550), Expect = 5e-56
 Identities = 148/487 (30%), Positives = 231/487 (47%), Gaps = 61/487 (12%)

Query: 28  PAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLG-----SSERDFF-----YH 77
           P P    R R  D  + +NV G R Q     L R+P T LG     +SE         Y 
Sbjct: 37  PGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYD 96

Query: 78  PETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEY 137
              ++++FDR P  F  +L+FYRTG LH     C+ A+ +E  ++GL    +  CC   Y
Sbjct: 97  EAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARY 156

Query: 138 KDRRRENAERLQDDADT----------------DTAGESALPTMTARQRVWRAFENPHTS 181
            +RR        +D+DT                + A   A      R+R+W   ENP  S
Sbjct: 157 LERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYS 216

Query: 182 TMALVFYYVTGFFIAVSVIANVVETVP---------------CGSSPGHIKELPCGERYA 226
             + +F  V+   +  S+ A  + ++P                G SP  +++ P   R  
Sbjct: 217 LPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRR-- 274

Query: 227 VAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI----GLVMTDN 282
                L+  C+  F+ E   RL  APS   F    +++ID+V++LP+Y+    G+ + D 
Sbjct: 275 -----LEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQ 329

Query: 283 ED-----VSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIII 337
                  +       R+ R+FR+ K +RHS GLR LG TLK    E+G LL  L + + +
Sbjct: 330 GGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSV 389

Query: 338 FATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLV 397
           F+ V + AEK      F +IPA +W+  V+MTT+GYGD+VP T+AGK+  S C L G+LV
Sbjct: 390 FSGVAYTAEKEEDVG-FNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILV 448

Query: 398 IALPVPVIVSNFSRIYHQNQRADKR-RAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQ 456
           +ALP+ +I + FS  Y + +  +   R         + ++  G + A +++ R    S +
Sbjct: 449 VALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRE--TSQE 506

Query: 457 LQSSEDE 463
            QS++ E
Sbjct: 507 GQSADLE 513


>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
           subfamily S, member 2 [Homo sapiens]
          Length = 477

 Score =  216 bits (549), Expect = 7e-56
 Identities = 130/421 (30%), Positives = 218/421 (51%), Gaps = 50/421 (11%)

Query: 39  QDALIVLNVSGTRFQTWQDTLERYPDTLLGS----SERDFF------YHPETQQYFFDRD 88
           +D  I +NV G + +    TL R+P+T LG       R+        Y    ++++FDR+
Sbjct: 15  EDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRN 74

Query: 89  PDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERL 148
           P++F ++L+FY TGKLH     C+ ++ +E+ ++G+    I  CC   Y  R+ E  +  
Sbjct: 75  PELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEK 134

Query: 149 QDDADTDTAGESALPTMTA----------------RQRVWRAFENPHTSTMALVFYYVTG 192
            D+     +  S+   + A                R+++W A +NP  S ++ VF  ++ 
Sbjct: 135 WDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSI 194

Query: 193 FFIAVSVIANVVETVP------CGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLL 246
             +  S+I   + ++P         +PG        E + +A+F          T E + 
Sbjct: 195 LVVMGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWF----------TFELVA 244

Query: 247 RLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMT-------DNEDVSGAFVTLRVFRVFR 299
           R A AP   +F ++ +++ID+++I+P+YI LV+           ++      LR+ R+FR
Sbjct: 245 RFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFR 304

Query: 300 IFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPA 359
           I K +RHS GLR LG TLK    E+G LL  L++ I IF+ V +  EK  +    T IPA
Sbjct: 305 ILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLAT-IPA 363

Query: 360 AFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRA 419
            +W+  V+MTT+GYGD+VP T AGK+  S C L+G+LV+ LP+ +I + FS  Y + ++ 
Sbjct: 364 CWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQL 423

Query: 420 D 420
           +
Sbjct: 424 E 424


>gi|19071574 potassium voltage-gated channel, subfamily G, member 3
           isoform 1 [Homo sapiens]
          Length = 436

 Score =  209 bits (531), Expect = 8e-54
 Identities = 139/414 (33%), Positives = 215/414 (51%), Gaps = 35/414 (8%)

Query: 37  RTQDALIVLNVSGTRFQTWQDTLERYP----DTLLGS-SERDFF-----YHPETQQYFFD 86
           R+  A +VLNV G R+   ++ L+ +P      L G  SERD       Y  E  +YFFD
Sbjct: 5   RSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFD 64

Query: 87  RDPDIFRHILNFYRT-GKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENA 145
           R  + F  IL + R  GKL +    C  ++  E+ ++GL    +  CC     DR  +  
Sbjct: 65  RHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTY 124

Query: 146 ERLQDDA-------DTDTAGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVS 198
                D        +    G  A P+    +R+ R FE P +S  A +   V+  F+ VS
Sbjct: 125 TFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVS 184

Query: 199 VIANVVETVP-CGSSPGHIKELPCGERYAVA-----FFCLDTACVMIFTVEYLLRLAAAP 252
           ++     T+P   ++    + L    RY+          ++  C+  FT E ++R   + 
Sbjct: 185 MVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSK 244

Query: 253 SRYRFVRSVMSIIDVVAILPYYIGLVMT----DNEDVSGAFVTLRVFRVFRIF---KFSR 305
           ++  FV+  ++IID++AI PYYI ++MT    +N  +  A VTLRV R+ RIF   K +R
Sbjct: 245 NKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLAR 304

Query: 306 HSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKG----SSASKFTSIPAAF 361
           H  GL+ LG TLK C  E+  LL  + +A+ IF+ +    E G    +S   FTSIPAA 
Sbjct: 305 HFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAAC 364

Query: 362 WYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQ 415
           W+ I++MTT+GYGDM P T+ G+I G +C +SG++++ALP+  I  +F + YH+
Sbjct: 365 WWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHE 418


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.134    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,767,723
Number of Sequences: 37866
Number of extensions: 1059443
Number of successful extensions: 3958
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 185
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 3349
Number of HSP's gapped (non-prelim): 454
length of query: 630
length of database: 18,247,518
effective HSP length: 108
effective length of query: 522
effective length of database: 14,157,990
effective search space: 7390470780
effective search space used: 7390470780
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.