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Search of human proteins with 93141212
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|93141212 sodium channel, voltage-gated, type II, alpha
isoform 1 [Homo sapiens]
(2005 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor... 3999 0.0
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor... 3999 0.0
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 3997 0.0
gi|126362949 sodium channel, voltage-gated, type III, alpha isof... 3490 0.0
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ... 3484 0.0
gi|126362947 sodium channel, voltage-gated, type III, alpha isof... 3399 0.0
gi|126362955 sodium channel, voltage-gated, type III, alpha isof... 3397 0.0
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 3100 0.0
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo... 2993 0.0
gi|237512982 voltage-gated sodium channel type V alpha isoform f... 2435 0.0
gi|30089970 voltage-gated sodium channel type V alpha isoform b ... 2419 0.0
gi|37622907 voltage-gated sodium channel type V alpha isoform a ... 2418 0.0
gi|150417967 voltage-gated sodium channel type V alpha isoform c... 2414 0.0
gi|150417969 voltage-gated sodium channel type V alpha isoform d... 2367 0.0
gi|237512980 voltage-gated sodium channel type V alpha isoform e... 2345 0.0
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ... 2118 0.0
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi... 1869 0.0
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom... 1343 0.0
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo... 1302 0.0
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated... 1018 0.0
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1... 426 e-118
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1... 420 e-117
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ... 420 e-117
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 338 4e-92
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 338 4e-92
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 337 7e-92
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 333 1e-90
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 333 1e-90
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 333 1e-90
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 333 1e-90
>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 3999 bits (10370), Expect = 0.0
Identities = 2005/2005 (100%), Positives = 2005/2005 (100%)
Query: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK
Sbjct: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
Query: 61 SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK
Sbjct: 61 SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
Query: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
Query: 181 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
Query: 241 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL
Sbjct: 241 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP
Sbjct: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI
Sbjct: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI
Sbjct: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS 540
GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS
Sbjct: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS 540
Query: 541 LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600
LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST
Sbjct: 541 LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600
Query: 601 FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660
FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP
Sbjct: 601 FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660
Query: 661 STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE 720
STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE
Sbjct: 661 STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE 720
Query: 721 SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH 780
SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH
Sbjct: 721 SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH 780
Query: 781 YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL 840
YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL
Sbjct: 781 YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL 840
Query: 841 ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 900
ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM
Sbjct: 841 ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 900
Query: 901 QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL 960
QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL
Sbjct: 901 QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL 960
Query: 961 TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK 1020
TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK
Sbjct: 961 TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK 1020
Query: 1021 IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS 1080
IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS
Sbjct: 1021 IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS 1080
Query: 1081 SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS 1140
SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS
Sbjct: 1081 SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS 1140
Query: 1141 SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT 1200
SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT
Sbjct: 1141 SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT 1200
Query: 1201 CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1260
CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK
Sbjct: 1201 CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1260
Query: 1261 WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF 1320
WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF
Sbjct: 1261 WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF 1320
Query: 1321 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV 1380
EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV
Sbjct: 1321 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV 1380
Query: 1381 NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ 1440
NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ
Sbjct: 1381 NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ 1440
Query: 1441 PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA
Sbjct: 1441 PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
Query: 1501 MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT 1560
MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT
Sbjct: 1501 MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT 1560
Query: 1561 NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV 1620
NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV
Sbjct: 1561 NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV 1620
Query: 1621 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1680
SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS
Sbjct: 1621 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1680
Query: 1681 NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS 1740
NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS
Sbjct: 1681 NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS 1740
Query: 1741 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800
SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE
Sbjct: 1741 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800
Query: 1801 VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1860
VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA
Sbjct: 1801 VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1860
Query: 1861 FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920
FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL
Sbjct: 1861 FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920
Query: 1921 LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK 1980
LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK
Sbjct: 1921 LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK 1980
Query: 1981 PEKEKFEKDKSEKEDKGKDIRESKK 2005
PEKEKFEKDKSEKEDKGKDIRESKK
Sbjct: 1981 PEKEKFEKDKSEKEDKGKDIRESKK 2005
>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 3999 bits (10370), Expect = 0.0
Identities = 2005/2005 (100%), Positives = 2005/2005 (100%)
Query: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK
Sbjct: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
Query: 61 SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK
Sbjct: 61 SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
Query: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
Query: 181 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
Query: 241 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL
Sbjct: 241 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP
Sbjct: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI
Sbjct: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI
Sbjct: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS 540
GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS
Sbjct: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS 540
Query: 541 LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600
LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST
Sbjct: 541 LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600
Query: 601 FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660
FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP
Sbjct: 601 FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660
Query: 661 STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE 720
STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE
Sbjct: 661 STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE 720
Query: 721 SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH 780
SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH
Sbjct: 721 SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH 780
Query: 781 YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL 840
YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL
Sbjct: 781 YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL 840
Query: 841 ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 900
ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM
Sbjct: 841 ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 900
Query: 901 QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL 960
QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL
Sbjct: 901 QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL 960
Query: 961 TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK 1020
TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK
Sbjct: 961 TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK 1020
Query: 1021 IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS 1080
IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS
Sbjct: 1021 IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS 1080
Query: 1081 SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS 1140
SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS
Sbjct: 1081 SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS 1140
Query: 1141 SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT 1200
SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT
Sbjct: 1141 SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT 1200
Query: 1201 CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1260
CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK
Sbjct: 1201 CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1260
Query: 1261 WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF 1320
WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF
Sbjct: 1261 WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF 1320
Query: 1321 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV 1380
EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV
Sbjct: 1321 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV 1380
Query: 1381 NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ 1440
NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ
Sbjct: 1381 NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ 1440
Query: 1441 PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA
Sbjct: 1441 PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
Query: 1501 MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT 1560
MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT
Sbjct: 1501 MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT 1560
Query: 1561 NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV 1620
NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV
Sbjct: 1561 NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV 1620
Query: 1621 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1680
SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS
Sbjct: 1621 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1680
Query: 1681 NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS 1740
NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS
Sbjct: 1681 NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS 1740
Query: 1741 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800
SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE
Sbjct: 1741 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800
Query: 1801 VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1860
VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA
Sbjct: 1801 VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1860
Query: 1861 FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920
FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL
Sbjct: 1861 FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920
Query: 1921 LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK 1980
LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK
Sbjct: 1921 LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK 1980
Query: 1981 PEKEKFEKDKSEKEDKGKDIRESKK 2005
PEKEKFEKDKSEKEDKGKDIRESKK
Sbjct: 1981 PEKEKFEKDKSEKEDKGKDIRESKK 2005
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 3997 bits (10365), Expect = 0.0
Identities = 2004/2005 (99%), Positives = 2005/2005 (100%)
Query: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK
Sbjct: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
Query: 61 SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK
Sbjct: 61 SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
Query: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
Query: 181 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
LEDFTFLRDPWNWLDFTVITFAYVTEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181 LEDFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
Query: 241 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL
Sbjct: 241 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP
Sbjct: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI
Sbjct: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI
Sbjct: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS 540
GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS
Sbjct: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS 540
Query: 541 LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600
LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST
Sbjct: 541 LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600
Query: 601 FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660
FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP
Sbjct: 601 FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660
Query: 661 STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE 720
STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE
Sbjct: 661 STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE 720
Query: 721 SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH 780
SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH
Sbjct: 721 SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH 780
Query: 781 YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL 840
YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL
Sbjct: 781 YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL 840
Query: 841 ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 900
ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM
Sbjct: 841 ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 900
Query: 901 QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL 960
QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL
Sbjct: 901 QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL 960
Query: 961 TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK 1020
TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK
Sbjct: 961 TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK 1020
Query: 1021 IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS 1080
IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS
Sbjct: 1021 IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS 1080
Query: 1081 SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS 1140
SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS
Sbjct: 1081 SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS 1140
Query: 1141 SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT 1200
SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT
Sbjct: 1141 SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT 1200
Query: 1201 CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1260
CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK
Sbjct: 1201 CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1260
Query: 1261 WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF 1320
WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF
Sbjct: 1261 WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF 1320
Query: 1321 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV 1380
EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV
Sbjct: 1321 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV 1380
Query: 1381 NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ 1440
NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ
Sbjct: 1381 NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ 1440
Query: 1441 PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA
Sbjct: 1441 PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
Query: 1501 MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT 1560
MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT
Sbjct: 1501 MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT 1560
Query: 1561 NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV 1620
NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV
Sbjct: 1561 NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV 1620
Query: 1621 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1680
SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS
Sbjct: 1621 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1680
Query: 1681 NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS 1740
NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS
Sbjct: 1681 NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS 1740
Query: 1741 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800
SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE
Sbjct: 1741 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800
Query: 1801 VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1860
VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA
Sbjct: 1801 VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1860
Query: 1861 FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920
FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL
Sbjct: 1861 FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920
Query: 1921 LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK 1980
LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK
Sbjct: 1921 LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK 1980
Query: 1981 PEKEKFEKDKSEKEDKGKDIRESKK 2005
PEKEKFEKDKSEKEDKGKDIRESKK
Sbjct: 1981 PEKEKFEKDKSEKEDKGKDIRESKK 2005
>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
[Homo sapiens]
Length = 2000
Score = 3490 bits (9050), Expect = 0.0
Identities = 1750/2010 (87%), Positives = 1865/2010 (92%), Gaps = 15/2010 (0%)
Query: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
MAQ++LVPPGP+SFR FTRESLAAIE+R AEEKAK+PK+E+ D DDEN PKPNSDLEAGK
Sbjct: 1 MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQ-DNDDENKPKPNSDLEAGK 59
Query: 61 SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
+LPFIYGDIPPEMVS PLEDLDPYYINKKTFIV+NKGKAI RFSAT ALYILTP NP+RK
Sbjct: 60 NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRK 119
Query: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
+AIKILVHSLF+MLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 179
Query: 181 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
LEDFTFLRDPWNWLDF+VI AYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239
Query: 241 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP +S+FE N TS+FN ++
Sbjct: 240 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTM 299
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
D NGT N T+S FNW +YI D SHFY L+GQ D LLCGN SDAGQCPEGYICVKAGRNP
Sbjct: 300 DSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNP 359
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
NYGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLI
Sbjct: 360 NYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLI 419
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA AAA SA SRDFSG GG+
Sbjct: 420 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAA-SAASRDFSGIGGL 478
Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKE--QSGEEEKNDRVRKSESEDSIRRKGFR 538
G ESSS ASKLSSKS KE +NRRKK++Q+E + + + D KSESEDS++R F
Sbjct: 479 GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
Query: 539 FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598
FS++G+RLT +K+F SPHQSLLSIRGSLFSPRRNS+ S+FSFRGRAKD+GSENDFADDEH
Sbjct: 539 FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
Query: 599 STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658
STFED++SRRDSLFVPHRHGERR+SNVSQAS +SR++P LP NGKMHS VDCNGVVSLVG
Sbjct: 599 STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658
Query: 659 GPSTLTS-AGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEE 717
GPS LTS GQL PEGTTTETE+RKRR SSY +SM++LED + RQRA+SIASILTNTMEE
Sbjct: 659 GPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEE 718
Query: 718 LEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMA 777
LEESRQKCPPCWY+FAN+ LIWDCC WLKVKHLVNL+VMDPFVDLAITICIVLNTLFMA
Sbjct: 719 LEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMA 778
Query: 778 MEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLME 837
MEHYPMTEQFSSVL+VGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IVSLSLME
Sbjct: 779 MEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLME 838
Query: 838 LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 897
LGL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 839 LGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 898
Query: 898 VGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 957
VGMQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQT
Sbjct: 899 VGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 958
Query: 958 MCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFV 1017
MCL VFM+VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGID+V
Sbjct: 959 MCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYV 1018
Query: 1018 KRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSG 1077
K K+RE QKAF RK K ++ + NK DSC+SN+T IEI K+LNYL+DGNGTTSG
Sbjct: 1019 KNKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSG 1073
Query: 1078 IG--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKL 1135
+G SSVEKYV+DE+DYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES++EESKEKL
Sbjct: 1074 VGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKL 1133
Query: 1136 NATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWW 1195
NATSSSEGSTVD+ P EGEQ E EPEE L+PEACFTE C++KF CQ+S EEGKGK+WW
Sbjct: 1134 NATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWW 1193
Query: 1196 NLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1255
NLRKTCY IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL
Sbjct: 1194 NLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1253
Query: 1256 EMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLR 1315
EMLLKWVAYGFQ YFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPLR
Sbjct: 1254 EMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLR 1313
Query: 1316 ALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMF 1375
ALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG MF
Sbjct: 1314 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMF 1373
Query: 1376 DVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSR 1435
D+S VNN S+C+AL + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR
Sbjct: 1374 DISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSR 1430
Query: 1436 NVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK 1495
+V+LQP YE+NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK
Sbjct: 1431 DVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK 1490
Query: 1496 KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQ 1555
KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDDQ
Sbjct: 1491 KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQ 1550
Query: 1556 SQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELI 1615
+ MT +L INLVFIVLFTGE VLKL+SLR+YYFTIGWNIFDFVVVILSIVGMFLAE+I
Sbjct: 1551 GKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMI 1610
Query: 1616 EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA 1675
EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA
Sbjct: 1611 EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA 1670
Query: 1676 IFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDK 1735
IFGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDPD
Sbjct: 1671 IFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDT 1730
Query: 1736 DHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1795
HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF
Sbjct: 1731 IHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1790
Query: 1796 EMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL 1855
EMFYEVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL
Sbjct: 1791 EMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL 1850
Query: 1856 DILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRA 1915
DILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSYEPITTTLKRKQEEVSA IIQR
Sbjct: 1851 DILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRN 1910
Query: 1916 YRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSY 1975
+R YLLKQ++K +SS Y K+ K PIK+D +IDKLN NSTPEKTD + STTSPPSY
Sbjct: 1911 FRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSY 1970
Query: 1976 DSVTKPEKEKFEKDKSEKEDKGKDIRESKK 2005
DSVTKP+KEKFEKDK EKE KGK++RE++K
Sbjct: 1971 DSVTKPDKEKFEKDKPEKESKGKEVRENQK 2000
>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
sapiens]
Length = 1998
Score = 3484 bits (9034), Expect = 0.0
Identities = 1759/2005 (87%), Positives = 1875/2005 (93%), Gaps = 14/2005 (0%)
Query: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
M Q+VLVPPGPDSF FFTRESLAAIE+RIAEEKAK PK ++KD DDENGPKPNSDLEAGK
Sbjct: 1 MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD-DDENGPKPNSDLEAGK 59
Query: 61 SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
+LPFIYGDIPPEMVS PLEDLDPYYINKKTFIVLNKGKAI RFSAT ALYILTPFNP+RK
Sbjct: 60 NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRK 119
Query: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
+AIKILVHSLF+MLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKI+ARGFC
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFC 179
Query: 181 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 180 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239
Query: 241 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+QWPP N+S E + N ++
Sbjct: 240 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEK-NITV 298
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
+ NGT N TV F+W YI+D + YFLEG DALLCGNSSDAGQCPEGY+CVKAGRNP
Sbjct: 299 NYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI
Sbjct: 359 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQ-AAAAAASAESRDFSGAGG 479
LAVVAMAYEEQNQATLEEAEQKEAEFQQM+EQLKKQQE AQ AA A AS SR+ S AG
Sbjct: 419 LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478
Query: 480 IGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKN-DRVRKSESEDSIRRKGFR 538
+ S+SSS ASKLSSKS KE +NRRKK+KQKEQSG EEK+ D +KSESEDSIRRKGFR
Sbjct: 479 L---SDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFR 535
Query: 539 FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598
FS+EG+RLTYEKR+SSPHQSLLSIRGSLFSPRRNSR SLFSFRGRAKD+GSENDFADDEH
Sbjct: 536 FSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEH 595
Query: 599 STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658
STFEDN+SRRDSLFVP RHGERR+SN+SQ SR+SR+L + P NGKMHS VDCNGVVSLVG
Sbjct: 596 STFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG 655
Query: 659 GPSTLTS-AGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEE 717
GPS TS GQLLPEGTTTETE+RKRRSSS+HVSMD LEDP+ RQRAMSIASILTNT+EE
Sbjct: 656 GPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEE 715
Query: 718 LEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMA 777
LEESRQKCPPCWYKF+N+ LIWDC WLKVKH+VNLVVMDPFVDLAITICIVLNTLFMA
Sbjct: 716 LEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMA 775
Query: 778 MEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLME 837
MEHYPMT+ F++VL+VGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIV+LSL+E
Sbjct: 776 MEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 835
Query: 838 LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 897
LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 836 LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 895
Query: 898 VGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 957
VGMQLFGKSYK+CVCKI++DC+LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQ
Sbjct: 896 VGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQA 955
Query: 958 MCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFV 1017
MCLTVFMMVMVIGNLVVLNLFLALLLSSFS+DNLAATDDDNEMNNLQIAV RM KG+ +V
Sbjct: 956 MCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYV 1015
Query: 1018 KRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSG 1077
KRKI EFIQ++F+RKQK LDEIKPL+DLNNKKDSC+SNHT EIGKDL+YLKD NGTTSG
Sbjct: 1016 KRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTA-EIGKDLDYLKDVNGTTSG 1074
Query: 1078 IG--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKL 1135
IG SSVEKY++DESDYMSFINNPSLTVTVPIAVGESDFENLNTE+FSSESD+EESKEKL
Sbjct: 1075 IGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKL 1134
Query: 1136 N-ATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLW 1194
N ++SSSEGSTVDIGAP E EQP VEPEE+LEPEACFTE CV++FKCCQI++EEG+GK W
Sbjct: 1135 NESSSSSEGSTVDIGAPVE-EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQW 1193
Query: 1195 WNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFI 1254
WNLR+TC++IVEHNWFETFIVFMILLSSGALAFEDIYI+QRKTIKTMLEYADKVFTYIFI
Sbjct: 1194 WNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFI 1253
Query: 1255 LEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1314
LEMLLKWVAYG+Q YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL
Sbjct: 1254 LEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1313
Query: 1315 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEM 1374
RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCIN TTG+
Sbjct: 1314 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDR 1373
Query: 1375 FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDS 1434
FD+ VNN+++C LIE N+TARWKNVKVNFDNVG GYLSLLQVATFKGWMDIMYAAVDS
Sbjct: 1374 FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDS 1433
Query: 1435 RNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1494
RNVELQPKYE++LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
Sbjct: 1434 RNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1493
Query: 1495 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDD 1554
KKYYNAMKKLGSKKPQKPIPRP NKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDD
Sbjct: 1494 KKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1553
Query: 1555 QSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAEL 1614
QS+ +T IL INLVFIVLFTGECVLKLISLR+YYFTIGWNIFDFVVVILSIVGMFLAEL
Sbjct: 1554 QSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAEL 1613
Query: 1615 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1674
IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
Sbjct: 1614 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1673
Query: 1675 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPD 1734
AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP+
Sbjct: 1674 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPN 1733
Query: 1735 KDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1794
K +PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD
Sbjct: 1734 KVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1793
Query: 1795 FEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1854
FEMFYEVWEKFDPDATQF+EF KLS FA AL+PPL + +PNK+QLIAMDLPMVSGDRIHC
Sbjct: 1794 FEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHC 1853
Query: 1855 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQR 1914
LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSY+PITTTLKRKQEEVSA+IIQR
Sbjct: 1854 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQR 1913
Query: 1915 AYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTS-PP 1973
AYRR+LLK+ VK+ S Y K+K K IKED +ID++NENS EKTD+T ST + PP
Sbjct: 1914 AYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPP 1973
Query: 1974 SYDSVTKPEKEKFEKDKSEKEDKGK 1998
SYD VTKP EK E++ +++ KGK
Sbjct: 1974 SYDRVTKPIVEKHEQEGKDEKAKGK 1998
>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
[Homo sapiens]
Length = 1951
Score = 3399 bits (8813), Expect = 0.0
Identities = 1712/2009 (85%), Positives = 1824/2009 (90%), Gaps = 62/2009 (3%)
Query: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
MAQ++LVPPGP+SFR FTRESLAAIE+R AEEKAK+PK+E+ D DDEN PKPNSDLEAGK
Sbjct: 1 MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQ-DNDDENKPKPNSDLEAGK 59
Query: 61 SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
+LPFIYGDIPPEMVS PLEDLDPYYINKKTFIV+NKGKAI RFSAT ALYILTP NP+RK
Sbjct: 60 NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRK 119
Query: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
+AIKILVHSLF+MLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 179
Query: 181 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
LEDFTFLRDPWNWLDF+VI AYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239
Query: 241 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP +S+FE N TS+FN ++
Sbjct: 240 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTM 299
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
D NGT N T+S FNW +YI D SHFY L+GQ D LLCGN SDAGQCPEGYICVKAGRNP
Sbjct: 300 DSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNP 359
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
NYGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLI
Sbjct: 360 NYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLI 419
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA AAA SA SRDFSG GG+
Sbjct: 420 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAA-SAASRDFSGIGGL 478
Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKE--QSGEEEKNDRVRKSESEDSIRRKGFR 538
G ESSS ASKLSSKS KE +NRRKK++Q+E + + + D KSESEDS++R F
Sbjct: 479 GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
Query: 539 FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598
FS++G+RLT +K+F SPHQSLLSIRGSLFSPRRNS+ S+FSFRGRAKD+GSENDFADDEH
Sbjct: 539 FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
Query: 599 STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658
STFED++SRRDSLFVPHRHGERR+SN
Sbjct: 599 STFEDSESRRDSLFVPHRHGERRNSN---------------------------------- 624
Query: 659 GPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEEL 718
GTTTETE+RKRR SSY +SM++LED + RQRA+SIASILTNTMEEL
Sbjct: 625 --------------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEEL 670
Query: 719 EESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAM 778
EESRQKCPPCWY+FAN+ LIWDCC WLKVKHLVNL+VMDPFVDLAITICIVLNTLFMAM
Sbjct: 671 EESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAM 730
Query: 779 EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL 838
EHYPMTEQFSSVL+VGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IVSLSLMEL
Sbjct: 731 EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL 790
Query: 839 GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 898
GL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV
Sbjct: 791 GLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 850
Query: 899 GMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 958
GMQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM
Sbjct: 851 GMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 910
Query: 959 CLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVK 1018
CL VFM+VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGID+VK
Sbjct: 911 CLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVK 970
Query: 1019 RKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGI 1078
K+RE QKAF RK K ++ + NK DSC+SN+T IEI K+LNYL+DGNGTTSG+
Sbjct: 971 NKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSGV 1025
Query: 1079 G--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLN 1136
G SSVEKYV+DE+DYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES++EESKEKLN
Sbjct: 1026 GTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLN 1085
Query: 1137 ATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWN 1196
ATSSSEGSTVD+ P EGEQ E EPEE L+PEACFTE C++KF CQ+S EEGKGK+WWN
Sbjct: 1086 ATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWN 1145
Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
LRKTCY IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
Query: 1257 MLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1316
MLLKWVAYGFQ YFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPLRA
Sbjct: 1206 MLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRA 1265
Query: 1317 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFD 1376
LSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG MFD
Sbjct: 1266 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFD 1325
Query: 1377 VSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRN 1436
+S VNN S+C+AL + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR+
Sbjct: 1326 ISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1382
Query: 1437 VELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
V+LQP YE+NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK
Sbjct: 1383 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1442
Query: 1497 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQS 1556
YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDDQ
Sbjct: 1443 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQG 1502
Query: 1557 QEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIE 1616
+ MT +L INLVFIVLFTGE VLKL+SLR+YYFTIGWNIFDFVVVILSIVGMFLAE+IE
Sbjct: 1503 KYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE 1562
Query: 1617 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1676
KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI
Sbjct: 1563 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1622
Query: 1677 FGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKD 1736
FGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDPD
Sbjct: 1623 FGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1682
Query: 1737 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1796
HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE
Sbjct: 1683 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1742
Query: 1797 MFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1856
MFYEVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD
Sbjct: 1743 MFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1802
Query: 1857 ILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAY 1916
ILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSYEPITTTLKRKQEEVSA IIQR +
Sbjct: 1803 ILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNF 1862
Query: 1917 RRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYD 1976
R YLLKQ++K +SS Y K+ K PIK+D +IDKLN NSTPEKTD + STTSPPSYD
Sbjct: 1863 RCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYD 1922
Query: 1977 SVTKPEKEKFEKDKSEKEDKGKDIRESKK 2005
SVTKP+KEKFEKDK EKE KGK++RE++K
Sbjct: 1923 SVTKPDKEKFEKDKPEKESKGKEVRENQK 1951
>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
[Homo sapiens]
Length = 1951
Score = 3397 bits (8807), Expect = 0.0
Identities = 1711/2009 (85%), Positives = 1823/2009 (90%), Gaps = 62/2009 (3%)
Query: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
MAQ++LVPPGP+SFR FTRESLAAIE+R AEEKAK+PK+E+ D DDEN PKPNSDLEAGK
Sbjct: 1 MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQ-DNDDENKPKPNSDLEAGK 59
Query: 61 SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
+LPFIYGDIPPEMVS PLEDLDPYYINKKTFIV+NKGKAI RFSAT ALYILTP NP+RK
Sbjct: 60 NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRK 119
Query: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
+AIKILVHSLF+MLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 179
Query: 181 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
LEDFTFLRDPWNWLDF+VI AYVTEFV LGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239
Query: 241 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP +S+FE N TS+FN ++
Sbjct: 240 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTM 299
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
D NGT N T+S FNW +YI D SHFY L+GQ D LLCGN SDAGQCPEGYICVKAGRNP
Sbjct: 300 DSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNP 359
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
NYGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLI
Sbjct: 360 NYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLI 419
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA AAA SA SRDFSG GG+
Sbjct: 420 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAA-SAASRDFSGIGGL 478
Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKE--QSGEEEKNDRVRKSESEDSIRRKGFR 538
G ESSS ASKLSSKS KE +NRRKK++Q+E + + + D KSESEDS++R F
Sbjct: 479 GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
Query: 539 FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598
FS++G+RLT +K+F SPHQSLLSIRGSLFSPRRNS+ S+FSFRGRAKD+GSENDFADDEH
Sbjct: 539 FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
Query: 599 STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658
STFED++SRRDSLFVPHRHGERR+SN
Sbjct: 599 STFEDSESRRDSLFVPHRHGERRNSN---------------------------------- 624
Query: 659 GPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEEL 718
GTTTETE+RKRR SSY +SM++LED + RQRA+SIASILTNTMEEL
Sbjct: 625 --------------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEEL 670
Query: 719 EESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAM 778
EESRQKCPPCWY+FAN+ LIWDCC WLKVKHLVNL+VMDPFVDLAITICIVLNTLFMAM
Sbjct: 671 EESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAM 730
Query: 779 EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL 838
EHYPMTEQFSSVL+VGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IVSLSLMEL
Sbjct: 731 EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL 790
Query: 839 GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 898
GL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV
Sbjct: 791 GLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 850
Query: 899 GMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 958
GMQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM
Sbjct: 851 GMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 910
Query: 959 CLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVK 1018
CL VFM+VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGID+VK
Sbjct: 911 CLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVK 970
Query: 1019 RKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGI 1078
K+RE QKAF RK K ++ + NK DSC+SN+T IEI K+LNYL+DGNGTTSG+
Sbjct: 971 NKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSGV 1025
Query: 1079 G--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLN 1136
G SSVEKYV+DE+DYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES++EESKEKLN
Sbjct: 1026 GTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLN 1085
Query: 1137 ATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWN 1196
ATSSSEGSTVD+ P EGEQ E EPEE L+PEACFTE C++KF CQ+S EEGKGK+WWN
Sbjct: 1086 ATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWN 1145
Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
LRKTCY IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
Query: 1257 MLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1316
MLLKWVAYGFQ YFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPLRA
Sbjct: 1206 MLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRA 1265
Query: 1317 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFD 1376
LSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG MFD
Sbjct: 1266 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFD 1325
Query: 1377 VSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRN 1436
+S VNN S+C+AL + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR+
Sbjct: 1326 ISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1382
Query: 1437 VELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
V+LQP YE+NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK
Sbjct: 1383 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1442
Query: 1497 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQS 1556
YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDDQ
Sbjct: 1443 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQG 1502
Query: 1557 QEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIE 1616
+ MT +L INLVFIVLFTGE VLKL+SLR+YYFTIGWNIFDFVVVILSIVGMFLAE+IE
Sbjct: 1503 KYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE 1562
Query: 1617 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1676
KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI
Sbjct: 1563 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1622
Query: 1677 FGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKD 1736
FGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDPD
Sbjct: 1623 FGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1682
Query: 1737 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1796
HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE
Sbjct: 1683 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1742
Query: 1797 MFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1856
MFYEVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD
Sbjct: 1743 MFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1802
Query: 1857 ILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAY 1916
ILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSYEPITTTLKRKQEEVSA IIQR +
Sbjct: 1803 ILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNF 1862
Query: 1917 RRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYD 1976
R YLLKQ++K +SS Y K+ K PIK+D +IDKLN NSTPEKTD + STTSPPSYD
Sbjct: 1863 RCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYD 1922
Query: 1977 SVTKPEKEKFEKDKSEKEDKGKDIRESKK 2005
SVTKP+KEKFEKDK EKE KGK++RE++K
Sbjct: 1923 SVTKPDKEKFEKDKPEKESKGKEVRENQK 1951
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 3100 bits (8038), Expect = 0.0
Identities = 1573/2006 (78%), Positives = 1746/2006 (87%), Gaps = 34/2006 (1%)
Query: 4 SVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLP 63
++L PPGP SF FT++SLA IEQRIAE K+K PK+E+KD DDE PKP+SDLEAGK LP
Sbjct: 2 AMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKD-DDEEAPKPSSDLEAGKQLP 60
Query: 64 FIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123
FIYGDIPP MVS PLEDLDPYY +KKTFIVLNKGK I RF+ATPALY+L+PF+P+R+++I
Sbjct: 61 FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI 120
Query: 124 KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183
KILVHSLF+MLIMCTILTNC+FMTM+NPPDWTKNVEYTFTGIYTFESL+KILARGFC+ +
Sbjct: 121 KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE 180
Query: 184 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
FTFLRDPWNWLDF VI FAY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ
Sbjct: 181 FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 240
Query: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
SVKKLSDVMILTVFCLSVFALIGLQLFMGNL++KC F NSL+ N
Sbjct: 241 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC-----------------FRNSLENN 283
Query: 304 GTTFNRTVSIFNWDEYIED-KSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNY 362
T SI N E ED + +FY+LEG DALLCG S+D+GQCPEGY CVK GRNP+Y
Sbjct: 284 ETL----ESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDY 339
Query: 363 GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 422
GYTSFDTFSWAFL+LFRLMTQD+WENLYQ TLRAAGKTYMIFFV+VIFLGSFYLINLILA
Sbjct: 340 GYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILA 399
Query: 423 VVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGV 482
VVAMAYEEQNQA +EEA+QKE EFQQML++LKK+QEEA+A AAAA AE + +G+
Sbjct: 400 VVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAA-AEYTSIRRSRIMGL 458
Query: 483 FSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKND--RVRKSESEDSIRRKGFRFS 540
SESSS SKLSSKS KE +NRRKKK QK+ S EEK D ++ KSESEDSIRRK F
Sbjct: 459 -SESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLG 517
Query: 541 LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600
+EG R +EKR S+P+QS LSIRGSLFS RR+SR SLFSF+GR +DIGSE +FADDEHS
Sbjct: 518 VEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSI 577
Query: 601 FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660
F DN+SRR SLFVPHR ERR SN+SQASR+ P+LP+NGKMHSAVDCNGVVSLV G
Sbjct: 578 FGDNESRRGSLFVPHRPQERRSSNISQASRSP---PMLPVNGKMHSAVDCNGVVSLVDGR 634
Query: 661 STLTSA-GQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELE 719
S L GQLLPEGTT + +KRR SSY +S D+L DP RQRAMS ASILTNT+EELE
Sbjct: 635 SALMLPNGQLLPEGTTNQIH-KKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELE 693
Query: 720 ESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAME 779
ESRQKCPP WY+FA+ LIW+C W+K K + +VMDPFVDLAITICIVLNTLFMAME
Sbjct: 694 ESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAME 753
Query: 780 HYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELG 839
H+PMTE+F +VL++GNLVFTGIF AEM LK+IAMDPY YFQ GWNIFD IV+LSL+EL
Sbjct: 754 HHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELF 813
Query: 840 LANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 899
LA+VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG
Sbjct: 814 LADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 873
Query: 900 MQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC 959
MQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQ MC
Sbjct: 874 MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC 933
Query: 960 LTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKR 1019
L V+MMVMVIGNLVVLNLFLALLLSSFSSDNL A ++D + NNLQIAV R++KGI++VK+
Sbjct: 934 LIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQ 993
Query: 1020 KIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIG 1079
+REFI KAF +K K EI+ EDLN KK++ ISNHT E+ K N+LK+ + SG G
Sbjct: 994 TLREFILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKD-KISGFG 1052
Query: 1080 SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATS 1139
SSV+K+++++SD SFI+NPSLTVTVPIA GESD EN+N EE SS+SD E SK +LN +S
Sbjct: 1053 SSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSS 1112
Query: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199
SSE STVD P EGE+ E EP S EPEACFT+ CVR+F CCQ++IE GKGK+WWN+RK
Sbjct: 1113 SSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRK 1172
Query: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLL 1259
TCYKIVEH+WFE+FIV MILLSSGALAFEDIYIE++KTIK +LEYADK+FTYIFILEMLL
Sbjct: 1173 TCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLL 1232
Query: 1260 KWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSR 1319
KW+AYG++ YFTNAWCWLDFLIVDVSLV+L AN LGYS+LG IKSLRTLRALRPLRALSR
Sbjct: 1233 KWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSR 1292
Query: 1320 FEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSV 1379
FEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY CIN T G F S
Sbjct: 1293 FEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ 1352
Query: 1380 VNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVEL 1439
V N SEC AL+ +Q RWKN+KVNFDNVGLGYLSLLQVATFKGW IMYAAVDS NV+
Sbjct: 1353 VPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDK 1412
Query: 1440 QPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYN 1499
QPKYE +LYMY+YFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYN
Sbjct: 1413 QPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYN 1472
Query: 1500 AMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEM 1559
AMKKLGSKKPQKPIPRP NK QG +FD VT Q FDISIM+LICLNMVTMMVE + QSQ M
Sbjct: 1473 AMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHM 1532
Query: 1560 TNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYF 1619
T +LYWIN+VFI+LFTGECVLKLISLR+YYFT+GWNIFDFVVVI+SIVGMFLA+LIE YF
Sbjct: 1533 TEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYF 1592
Query: 1620 VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1679
VSPTLFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM
Sbjct: 1593 VSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1652
Query: 1680 SNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPG 1739
SNFAYVK+E GI+DMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP K HPG
Sbjct: 1653 SNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPG 1712
Query: 1740 SSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFY 1799
SSV+GDCGNPSVGIF+FVSYIIISFLVVVNMYIAVILENFSVATEES EPLSEDDFEMFY
Sbjct: 1713 SSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFY 1772
Query: 1800 EVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF 1859
EVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF
Sbjct: 1773 EVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF 1832
Query: 1860 AFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRY 1919
AFTKRVLGESGEMD+LR QMEERFM++NPSKVSYEPITTTLKRKQE+VSA +IQRAYRRY
Sbjct: 1833 AFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRY 1892
Query: 1920 LLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVT 1979
L+Q VK +SSIY KD G D K+D D +NENS+PEKTD T STTSPPSYDSVT
Sbjct: 1893 RLRQNVKNISSIYIKD-GDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVT 1951
Query: 1980 KPEKEKFEKDKSEKEDKGKDIRESKK 2005
KP+KEK+E+D++EKEDKGKD +ESKK
Sbjct: 1952 KPDKEKYEQDRTEKEDKGKDSKESKK 1977
>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
sapiens]
Length = 1980
Score = 2993 bits (7759), Expect = 0.0
Identities = 1537/2027 (75%), Positives = 1730/2027 (85%), Gaps = 71/2027 (3%)
Query: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQ---ERKDEDDENGPKPNSDLE 57
MA +L PPGPDSF+ FT ESLA IE+RIAE K K+P + +++D+++ PKPNSDLE
Sbjct: 1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60
Query: 58 AGKSLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNP 117
AGKSLPFIYGDIP +V+VPLED DPYY+ +KTF+VLN+GK + RFSATPALYIL+PFN
Sbjct: 61 AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120
Query: 118 IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILAR 177
IR++AIKIL+HS+F+M+IMCTILTNCVFMT SNPPDW+KNVEYTFTGIYTFESL+KI+AR
Sbjct: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180
Query: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTI 237
GFC++ FTFLRDPWNWLDF+VI AY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTI
Sbjct: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240
Query: 238 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFN 297
VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+ WP IN FN
Sbjct: 241 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWP-------IN----FN 289
Query: 298 NSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAG 357
S NGT F+W+EYI +K++FY + G + LLCGNSSDAGQCPEGY C+KAG
Sbjct: 290 ESYLENGTKG------FDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAG 343
Query: 358 RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLI 417
RNPNYGYTSFDTFSWAFL+LFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIF+GSFYL+
Sbjct: 344 RNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLV 403
Query: 418 NLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASA-----ESR 472
NLILAVVAMAYEEQNQATLEEAEQKEAEF+ MLEQLKKQQEEAQAAA A SA ++
Sbjct: 404 NLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAI 463
Query: 473 DFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKND--RVRKSESED 530
+ G G G SSS SKLSSKS KE +NRRKK+KQKE S EEK D +V KSESED
Sbjct: 464 EEEGEEG-GGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESED 522
Query: 531 SIRRKGFRFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRG--RAKDIG 588
+RRK FR L +R+ ++FS +QSLLSI GS F R NS++S+FSFRG R +D G
Sbjct: 523 GMRRKAFR--LPDNRIG--RKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPG 578
Query: 589 SENDFADDEHSTFEDNDSRRDSLFVPHRHGERR-----HSNVSQASRASRVLPILPMNGK 643
SEN+FADDEHST E+++ RRDSLF+P R ERR +S SQ SR+SR+ P L + K
Sbjct: 579 SENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVK 638
Query: 644 MHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQR 703
+S VDCNGVVSL+GGP + G+LLPE TT E EI+K+ S VSMD L + R
Sbjct: 639 RNSTVDCNGVVSLIGGPGSHIG-GRLLPEATT-EVEIKKKGPGSLLVSMDQLASYGRKDR 696
Query: 704 AMSIASILTNTM-EELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVD 762
SI S++TNT+ EELEES++KCPPCWYKFAN LIW+C W+K+K +VNL+VMDPFVD
Sbjct: 697 INSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVD 756
Query: 763 LAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEG 822
LAITICIVLNTLFMAMEH+PMT QF VL+VGNLVFTGIFTAEMFLK+IAMDPYYYFQEG
Sbjct: 757 LAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEG 816
Query: 823 WNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 882
WNIFDGFIVSLSLMEL LA+VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG
Sbjct: 817 WNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 876
Query: 883 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGE 942
NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI+ DCELPRWHMHDFFHSFLIVFRVLCGE
Sbjct: 877 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGE 936
Query: 943 WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNN 1002
WIETMWDCMEVAGQ MCL VFMMVMVIGNLVVLNLFLALLLSSFS+DNLAATDDD EMNN
Sbjct: 937 WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNN 996
Query: 1003 LQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIG 1062
LQI+V R++KG+ + K K+ F+Q F KQ+ DE+KPL++L KK +CI+NHT +I
Sbjct: 997 LQISVIRIKKGVAWTKLKVHAFMQAHF--KQREADEVKPLDELYEKKANCIANHTGADIH 1054
Query: 1063 KDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEF 1122
++ ++ K+GNGTTSGIGSSVEKY++DE D+MSFINNP+LTV VPIAVGESDFENLNTE+
Sbjct: 1055 RNGDFQKNGNGTTSGIGSSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTEDV 1113
Query: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182
SSESD E SK+KL+ TSSSEGST+DI E E P +PEE L+P+ACFTE CV++FKCC
Sbjct: 1114 SSESDPEGSKDKLDDTSSSEGSTIDIKPEVE-EVPVEQPEEYLDPDACFTEGCVQRFKCC 1172
Query: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242
Q++IEEG GK WW LRKTC+ IVEHNWFETFI+FMILLSSGALAFEDIYIEQRKTI+T+L
Sbjct: 1173 QVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTIL 1232
Query: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302
EYADKVFTYIFILEMLLKW AYGF +FTNAWCWLDFLIV VSLVSL ANALGYSELGAI
Sbjct: 1233 EYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAI 1292
Query: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362
KSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK
Sbjct: 1293 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1352
Query: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTA-RWKNVKVNFDNVGLGYLSLLQVATF 1421
+++C N T+ F++ VNN +EC+ L+E N T RWKNVK+NFDNVG GYL+LLQVATF
Sbjct: 1353 YHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATF 1412
Query: 1422 KGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1481
KGWMDIMYAAVDSR + QPKYEDN+YMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKK
Sbjct: 1413 KGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1472
Query: 1482 KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILI 1541
KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+VFDFVT+Q FDI IM+LI
Sbjct: 1473 KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLI 1532
Query: 1542 CLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVV 1601
CLNMVTMMVETD QS++M NILYWINLVF++ FT ECVLK+ +LR+YYFTIGWNIFDFVV
Sbjct: 1533 CLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVV 1592
Query: 1602 VILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661
VILSIVGMFLA++IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF
Sbjct: 1593 VILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1652
Query: 1662 NIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLA 1721
NIGLLLFLVMFI++IFGMSNFAYVK E GIDDMFNFETFGNSMICLFQITTSAGWDGLL
Sbjct: 1653 NIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLL 1712
Query: 1722 PILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSV 1781
PILN PPDC DK+HPGS KGDCGNPSVGIFFFVSYIIISFL+VVNMYIA+ILENFSV
Sbjct: 1713 PILNR-PPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSV 1771
Query: 1782 ATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIA 1841
ATEESA+PLSEDDFE FYE+WEKFDPDATQFIE+ KL+DFADAL+ PL + KPN ++LIA
Sbjct: 1772 ATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIA 1831
Query: 1842 MDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLK 1901
MDLPMVSGDRIHCLDILFAFTKRVLG+SGE+D LR QMEERF+ASNPSKVSYEPITTTL+
Sbjct: 1832 MDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLR 1891
Query: 1902 RKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENST-P 1960
RKQEEVSA+++QRAYR +L + +G C + T +KL T
Sbjct: 1892 RKQEEVSAVVLQRAYRGHLAR-------------RGFIC------KKTTSNKLENGGTHR 1932
Query: 1961 EKTDMTPSTTSPPSYDSVTKPEKEK---FEKDKSEKEDKGKDIRESK 2004
EK + TPST S PSYDSVTKPEKEK E+ + E+ + K++RESK
Sbjct: 1933 EKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESK 1979
>gi|237512982 voltage-gated sodium channel type V alpha isoform f
[Homo sapiens]
Length = 1962
Score = 2435 bits (6310), Expect = 0.0
Identities = 1290/2027 (63%), Positives = 1526/2027 (75%), Gaps = 122/2027 (6%)
Query: 6 LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
L+P G SFR FTRESLAAIE+R+AE++A+ ++ R+ +E P+P DL+A K L
Sbjct: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
Query: 63 PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
P +YG+ P E++ PLEDLDP+Y +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
Query: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
+KILVHSLFNMLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KILARGFCL
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
Query: 183 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
FTFLRDPWNWLDF+VI AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
Query: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++ N T+ N S+
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
+ +G + + D Y+ D ++ G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
LAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ E G+
Sbjct: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
S SS S L+ + E RR K++++ SG EE DR+ KS+SED R
Sbjct: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
Query: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
H SL R+SR S+F+FR R D+GSE DFADDE+S
Sbjct: 508 ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
Query: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
T +++S SL VP RR S Q S + P ++GK +S VDCNGVVSL+G
Sbjct: 550 TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
Query: 659 GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708
G TS G L P TTT +E + +S +D E+P +RQRA+S
Sbjct: 607 GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
Query: 709 SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
S+LT+ +EELEESR KCPPCW + A LIW+CC W+ +K V LVVMDPF DL IT+C
Sbjct: 667 SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
Query: 769 IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
IVLNTLFMA+EHY MT +F +L VGNLVFTGIFTAEM KIIA+DPYYYFQ+GWNIFD
Sbjct: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
Query: 829 FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
IV LSLMELGL+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 787 IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
Query: 889 AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
AIIVFIFAVVGMQLFGK+Y E + S+ LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 847 AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
Query: 949 DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 905 DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
Query: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059
R+Q+G+ FVKR +F + + +K AL + SCI+ T
Sbjct: 965 RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
Query: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119
++ + G G G+ +P V VPIAV ESD ++
Sbjct: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
Query: 1120 EEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEG-EQPEVEPEESLEPEACFTEDCVRK 1178
+E +S EES ++ S SEGST D+ AE EQ ++ +PE CFTE CVR+
Sbjct: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121
Query: 1179 FKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTI 1238
CC + + GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTI
Sbjct: 1122 CPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTI 1181
Query: 1239 KTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSE 1298
K +LEYADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E
Sbjct: 1182 KVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 1241
Query: 1299 LGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNL 1358
+G IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNL
Sbjct: 1242 MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1301
Query: 1359 FAGKFYHCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQ 1417
FAGKF CIN T G++ + ++VNN S+C++L + + W VKVNFDNVG GYL+LLQ
Sbjct: 1302 FAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQ 1360
Query: 1418 VATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFN 1477
VATFKGWMDIMYAAVDSR E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFN
Sbjct: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420
Query: 1478 QQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISI 1537
QQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++I
Sbjct: 1421 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTI 1480
Query: 1538 MILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIF 1597
M LICLNMVTMMVETDDQS E NIL INL+F+ +FTGEC++KL +LR+YYFT WNIF
Sbjct: 1481 MFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIF 1540
Query: 1598 DFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSL 1657
DFVVVILSIVG L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSL
Sbjct: 1541 DFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1600
Query: 1658 PALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWD 1717
PALFNIGLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWD
Sbjct: 1601 PALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWD 1660
Query: 1718 GLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILE 1777
GLL+PILN+GPP CDP + S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILE
Sbjct: 1661 GLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILE 1719
Query: 1778 NFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKV 1837
NFSVATEES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL PL IAKPN++
Sbjct: 1720 NFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQI 1779
Query: 1838 QLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPIT 1897
LI MDLPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPIT
Sbjct: 1780 SLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPIT 1839
Query: 1898 TTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLN 1955
TTL+RK EEVSA++IQRA+RR+LL++ +K S ++++ G + P +E + ++
Sbjct: 1840 TTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMS 1899
Query: 1956 ENST----PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
EN + P + ST+ PPSYDSVT+ + + D S ED
Sbjct: 1900 ENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 1946
>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
sapiens]
Length = 2015
Score = 2419 bits (6268), Expect = 0.0
Identities = 1294/2080 (62%), Positives = 1528/2080 (73%), Gaps = 175/2080 (8%)
Query: 6 LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
L+P G SFR FTRESLAAIE+R+AE++A+ ++ R+ +E P+P DL+A K L
Sbjct: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
Query: 63 PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
P +YG+ P E++ PLEDLDP+Y +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
Query: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
+KILVHSLFNMLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KILARGFCL
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
Query: 183 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
FTFLRDPWNWLDF+VI AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
Query: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++ N T+ N S+
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
+ +G + + D Y+ D ++ G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
LAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ E G+
Sbjct: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
S SS S L+ + E RR K++++ SG EE DR+ KS+SED R
Sbjct: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
Query: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
H SL R+SR S+F+FR R D+GSE DFADDE+S
Sbjct: 508 ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
Query: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
T +++S SL VP RR S Q S + P ++GK +S VDCNGVVSL+G
Sbjct: 550 TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
Query: 659 GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708
G TS G L P TTT +E + +S +D E+P +RQRA+S
Sbjct: 607 GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
Query: 709 SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
S+LT+ +EELEESR KCPPCW + A LIW+CC W+ +K V LVVMDPF DL IT+C
Sbjct: 667 SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
Query: 769 IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
IVLNTLFMA+EHY MT +F +L VGNLVFTGIFTAEM KIIA+DPYYYFQ+GWNIFD
Sbjct: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
Query: 829 FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
IV LSLMELGL+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 787 IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
Query: 889 AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
AIIVFIFAVVGMQLFGK+Y E + S+ LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 847 AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
Query: 949 DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 905 DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
Query: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059
R+Q+G+ FVKR +F + + +K AL + SCI+ T
Sbjct: 965 RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
Query: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119
++ + G G G+ +P V VPIAV ESD ++
Sbjct: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
Query: 1120 EEFSSESDMEESKEK--------------------LNATSSSEGST------------VD 1147
+E +S EES ++ ++AT+SSE +
Sbjct: 1062 DEENSLGTEEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAE 1121
Query: 1148 IGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQIS 1185
AP GE PE E +PE CFTE CVR+ CC +
Sbjct: 1122 PQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVD 1181
Query: 1186 IEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYA 1245
+ GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYA
Sbjct: 1182 TTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYA 1241
Query: 1246 DKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSL 1305
DK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSL
Sbjct: 1242 DKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSL 1301
Query: 1306 RTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1365
RTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF
Sbjct: 1302 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1361
Query: 1366 CINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGW 1424
CIN T G++ + ++VNN S+C++L + + W VKVNFDNVG GYL+LLQVATFKGW
Sbjct: 1362 CINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKGW 1420
Query: 1425 MDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFG 1484
MDIMYAAVDSR E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK G
Sbjct: 1421 MDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLG 1480
Query: 1485 GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLN 1544
GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICLN
Sbjct: 1481 GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLN 1540
Query: 1545 MVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVIL 1604
MVTMMVETDDQS E NIL INL+F+ +FTGEC++KL +LR+YYFT WNIFDFVVVIL
Sbjct: 1541 MVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVIL 1600
Query: 1605 SIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1664
SIVG L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIG
Sbjct: 1601 SIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIG 1660
Query: 1665 LLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPIL 1724
LLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PIL
Sbjct: 1661 LLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPIL 1720
Query: 1725 NSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATE 1784
N+GPP CDP + S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATE
Sbjct: 1721 NTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATE 1779
Query: 1785 ESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDL 1844
ES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL PL IAKPN++ LI MDL
Sbjct: 1780 ESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDL 1839
Query: 1845 PMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQ 1904
PMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1840 PMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKH 1899
Query: 1905 EEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST--- 1959
EEVSA++IQRA+RR+LL++ +K S ++++ G + P +E + ++EN +
Sbjct: 1900 EEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPL 1959
Query: 1960 -PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
P + ST+ PPSYDSVT+ + + D S ED
Sbjct: 1960 GPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 1999
>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
sapiens]
Length = 2016
Score = 2418 bits (6267), Expect = 0.0
Identities = 1294/2081 (62%), Positives = 1528/2081 (73%), Gaps = 176/2081 (8%)
Query: 6 LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
L+P G SFR FTRESLAAIE+R+AE++A+ ++ R+ +E P+P DL+A K L
Sbjct: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
Query: 63 PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
P +YG+ P E++ PLEDLDP+Y +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
Query: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
+KILVHSLFNMLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KILARGFCL
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
Query: 183 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
FTFLRDPWNWLDF+VI AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
Query: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++ N T+ N S+
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
+ +G + + D Y+ D ++ G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
LAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ E G+
Sbjct: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
S SS S L+ + E RR K++++ SG EE DR+ KS+SED R
Sbjct: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
Query: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
H SL R+SR S+F+FR R D+GSE DFADDE+S
Sbjct: 508 ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
Query: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
T +++S SL VP RR S Q S + P ++GK +S VDCNGVVSL+G
Sbjct: 550 TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
Query: 659 GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708
G TS G L P TTT +E + +S +D E+P +RQRA+S
Sbjct: 607 GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
Query: 709 SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
S+LT+ +EELEESR KCPPCW + A LIW+CC W+ +K V LVVMDPF DL IT+C
Sbjct: 667 SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
Query: 769 IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
IVLNTLFMA+EHY MT +F +L VGNLVFTGIFTAEM KIIA+DPYYYFQ+GWNIFD
Sbjct: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
Query: 829 FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
IV LSLMELGL+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 787 IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
Query: 889 AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
AIIVFIFAVVGMQLFGK+Y E + S+ LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 847 AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
Query: 949 DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 905 DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
Query: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059
R+Q+G+ FVKR +F + + +K AL + SCI+ T
Sbjct: 965 RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
Query: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119
++ + G G G+ +P V VPIAV ESD ++
Sbjct: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
Query: 1120 EEFSSESDMEESKEK---------------------LNATSSSEGST------------V 1146
+E +S EES ++ ++AT+SSE
Sbjct: 1062 DEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKA 1121
Query: 1147 DIGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQI 1184
+ AP GE PE E +PE CFTE CVR+ CC +
Sbjct: 1122 EPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1181
Query: 1185 SIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1244
+ GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEY
Sbjct: 1182 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1241
Query: 1245 ADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1304
ADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1242 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1301
Query: 1305 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1364
LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF
Sbjct: 1302 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1361
Query: 1365 HCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKG 1423
CIN T G++ + ++VNN S+C++L + + W VKVNFDNVG GYL+LLQVATFKG
Sbjct: 1362 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKG 1420
Query: 1424 WMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1483
WMDIMYAAVDSR E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK
Sbjct: 1421 WMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1480
Query: 1484 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICL 1543
GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICL
Sbjct: 1481 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1540
Query: 1544 NMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVI 1603
NMVTMMVETDDQS E NIL INL+F+ +FTGEC++KL +LR+YYFT WNIFDFVVVI
Sbjct: 1541 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1600
Query: 1604 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663
LSIVG L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1601 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1660
Query: 1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1723
GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1661 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1720
Query: 1724 LNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1783
LN+GPP CDP + S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1721 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
Query: 1784 EESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMD 1843
EES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL PL IAKPN++ LI MD
Sbjct: 1780 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1839
Query: 1844 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRK 1903
LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1840 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1899
Query: 1904 QEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST-- 1959
EEVSA++IQRA+RR+LL++ +K S ++++ G + P +E + ++EN +
Sbjct: 1900 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1959
Query: 1960 --PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
P + ST+ PPSYDSVT+ + + D S ED
Sbjct: 1960 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 2000
>gi|150417967 voltage-gated sodium channel type V alpha isoform c
[Homo sapiens]
Length = 2016
Score = 2414 bits (6255), Expect = 0.0
Identities = 1291/2081 (62%), Positives = 1528/2081 (73%), Gaps = 176/2081 (8%)
Query: 6 LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
L+P G SFR FTRESLAAIE+R+AE++A+ ++ R+ +E P+P DL+A K L
Sbjct: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
Query: 63 PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
P +YG+ P E++ PLEDLDP+Y +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
Query: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
+KILVHSLFNMLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KILARGFCL
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
Query: 183 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
FTFLRDPWNWLDF+VI AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
Query: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++ N T+ N S+
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
+ +G + + D Y+ D ++ G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
LAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ E G+
Sbjct: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
S SS S L+ + E RR K++++ SG EE DR+ KS+SED R
Sbjct: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
Query: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
H SL R+SR S+F+FR R D+GSE DFADDE+S
Sbjct: 508 ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
Query: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
T +++S SL VP RR S Q S + P ++GK +S VDCNGVVSL+G
Sbjct: 550 TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
Query: 659 GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708
G TS G L P TTT +E + +S +D E+P +RQRA+S
Sbjct: 607 GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
Query: 709 SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
S+LT+ +EELEESR KCPPCW + A LIW+CC W+ +K V LVVMDPF DL IT+C
Sbjct: 667 SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
Query: 769 IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
IVLNTLFMA+EHY MT +F +L VGNLVFTGIFTAEM KIIA+DPYYYFQ+GWNIFD
Sbjct: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
Query: 829 FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
IV LSLMELGL+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 787 IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
Query: 889 AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
AIIVFIFAVVGMQLFGK+Y E + S+ LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 847 AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
Query: 949 DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 905 DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
Query: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059
R+Q+G+ FVKR +F + + +K AL + SCI+ T
Sbjct: 965 RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
Query: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119
++ + G G G+ +P V VPIAV ESD ++
Sbjct: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
Query: 1120 EEFSSESDMEESKEK---------------------LNATSSSEGST------------V 1146
+E +S EES ++ ++AT+SSE
Sbjct: 1062 DEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKA 1121
Query: 1147 DIGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQI 1184
+ AP GE PE E +PE CFTE CVR+ CC +
Sbjct: 1122 EPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1181
Query: 1185 SIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1244
+ GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEY
Sbjct: 1182 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1241
Query: 1245 ADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1304
ADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1242 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1301
Query: 1305 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1364
LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF
Sbjct: 1302 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1361
Query: 1365 HCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKG 1423
CIN T G++ + ++VNN S+C++L + + W VKVNFDNVG GYL+LLQVATFKG
Sbjct: 1362 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKG 1420
Query: 1424 WMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1483
WMDIMYAAVDSR E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK
Sbjct: 1421 WMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1480
Query: 1484 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICL 1543
GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICL
Sbjct: 1481 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1540
Query: 1544 NMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVI 1603
NMVTMMVETDDQS E NIL INL+F+ +FTGEC++KL +LR+YYFT WNIFDFVVVI
Sbjct: 1541 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1600
Query: 1604 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663
LSIVG L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1601 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1660
Query: 1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1723
GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1661 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1720
Query: 1724 LNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1783
LN+GPP CDP + S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1721 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
Query: 1784 EESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMD 1843
EES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL PL IAKPN++ LI MD
Sbjct: 1780 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1839
Query: 1844 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRK 1903
LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1840 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1899
Query: 1904 QEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST-- 1959
EEVSA++IQRA+RR+LL++ +K S ++++ G + P +E + ++EN +
Sbjct: 1900 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1959
Query: 1960 --PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
P + ST+ PPSYDSVT+ + + D S ED
Sbjct: 1960 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 2000
>gi|150417969 voltage-gated sodium channel type V alpha isoform d
[Homo sapiens]
Length = 1998
Score = 2367 bits (6135), Expect = 0.0
Identities = 1274/2081 (61%), Positives = 1511/2081 (72%), Gaps = 194/2081 (9%)
Query: 6 LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
L+P G SFR FTRESLAAIE+R+AE++A+ ++ R+ +E P+P DL+A K L
Sbjct: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
Query: 63 PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
P +YG+ P E++ PLEDLDP+Y +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
Query: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
+KILVHSLFNMLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KILARGFCL
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
Query: 183 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
FTFLRDPWNWLDF+VI AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
Query: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++ N T+ N S+
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
+ +G + + D Y+ D ++ G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
LAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ E G+
Sbjct: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
S SS S L+ + E RR K++++ SG EE DR+ KS+SED R
Sbjct: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
Query: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
H SL R+SR S+F+FR R D+GSE DFADDE+S
Sbjct: 508 ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
Query: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
T +++S SL VP RR S Q S + P ++GK +S VDCNGVVSL+G
Sbjct: 550 TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
Query: 659 GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708
G TS G L P TTT +E + +S +D E+P +RQRA+S
Sbjct: 607 GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
Query: 709 SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
S+LT+ +EELEESR KCPPCW + A LIW+CC W+ +K V LVVMDPF DL IT+C
Sbjct: 667 SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
Query: 769 IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
IVLNTLFMA+EHY MT +F +L VGNLVFTGIFTAEM KIIA+DPYYYFQ+GWNIFD
Sbjct: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
Query: 829 FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
IV LSLMELGL+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 787 IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
Query: 889 AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
AIIVFIFAVVGMQLFGK+Y E + S+ LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 847 AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
Query: 949 DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 905 DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
Query: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059
R+Q+G+ FVKR +F + + +K AL + SCI+ T
Sbjct: 965 RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
Query: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119
++ + G G G+ +P V VPIAV ESD ++
Sbjct: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
Query: 1120 EEFSSESDMEESKEK---------------------LNATSSSEGST------------V 1146
+E +S EES ++ ++AT+SSE
Sbjct: 1062 DEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKA 1121
Query: 1147 DIGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQI 1184
+ AP GE PE E +PE CFTE CVR+ CC +
Sbjct: 1122 EPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1181
Query: 1185 SIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1244
+ GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEY
Sbjct: 1182 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1241
Query: 1245 ADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1304
ADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1242 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1301
Query: 1305 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1364
LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF
Sbjct: 1302 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1361
Query: 1365 HCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKG 1423
CIN T G++ + ++VNN S+C++L + + W VKVNFDNVG GYL+LLQV
Sbjct: 1362 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQV----- 1415
Query: 1424 WMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1483
E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK
Sbjct: 1416 -------------YEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1462
Query: 1484 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICL 1543
GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICL
Sbjct: 1463 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1522
Query: 1544 NMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVI 1603
NMVTMMVETDDQS E NIL INL+F+ +FTGEC++KL +LR+YYFT WNIFDFVVVI
Sbjct: 1523 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1582
Query: 1604 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663
LSIVG L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1583 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1642
Query: 1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1723
GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1643 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1702
Query: 1724 LNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1783
LN+GPP CDP + S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1703 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1761
Query: 1784 EESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMD 1843
EES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL PL IAKPN++ LI MD
Sbjct: 1762 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1821
Query: 1844 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRK 1903
LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1822 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1881
Query: 1904 QEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST-- 1959
EEVSA++IQRA+RR+LL++ +K S ++++ G + P +E + ++EN +
Sbjct: 1882 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1941
Query: 1960 --PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
P + ST+ PPSYDSVT+ + + D S ED
Sbjct: 1942 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 1982
>gi|237512980 voltage-gated sodium channel type V alpha isoform e
[Homo sapiens]
Length = 1983
Score = 2345 bits (6076), Expect = 0.0
Identities = 1267/2080 (60%), Positives = 1502/2080 (72%), Gaps = 207/2080 (9%)
Query: 6 LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
L+P G SFR FTRESLAAIE+R+AE++A+ ++ R+ +E P+P DL+A K L
Sbjct: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
Query: 63 PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
P +YG+ P E++ PLEDLDP+Y +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
Query: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
+KILVHSLFNMLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KILARGFCL
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
Query: 183 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
FTFLRDPWNWLDF+VI AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
Query: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++ N T+ N S+
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
+ +G + + D Y+ D ++ G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
LAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ E G+
Sbjct: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
S SS S L+ + E RR K++++ SG EE DR+ KS+SED R
Sbjct: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPR------ 504
Query: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
+ H SL R+SR S+F+FR R D+GSE DFADDE+S
Sbjct: 505 -------------AMNHLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
Query: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
T +++S SL VP RR S Q S + P ++GK +S VDCNGVVSL+G
Sbjct: 550 TAGESESHHTSLLVP--WPLRRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
Query: 659 GPSTLTSAGQLL--------PEGTTTETEI--RKRRSSSYHVSMDLLEDPTSRQRAMSIA 708
G TS G L P TTT +E + +S +D E+P +RQRA+S
Sbjct: 607 GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
Query: 709 SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
S+LT+ +EELEESR KCPPCW + A LIW+CC W+ +K V LVVMDPF DL IT+C
Sbjct: 667 SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
Query: 769 IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
IVLNTLFMA+EHY MT +F +L VGNLVFTGIFTAEM KIIA+DPYYYFQ+GWNIFD
Sbjct: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
Query: 829 FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
IV LSLMELGL+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 787 IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
Query: 889 AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
AIIVFIFAVVGMQLFGK+Y E + S+ LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 847 AIIVFIFAVVGMQLFGKNYSE--LRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
Query: 949 DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 905 DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
Query: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISN------HTTI 1059
R+Q+G+ FVKR +F + + +K AL + SCI+ T
Sbjct: 965 RIQRGLRFVKRTTWDFCCGLLRQRPQKPAAL-------AAQGQLPSCIATPYSPPPPETE 1017
Query: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFE---- 1115
++ + G G G+ +P V VPIAV ESD +
Sbjct: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
Query: 1116 ----NLNTEEFSSESDME------------ESKEKLNATSSSEGST------------VD 1147
+L TEE SS+ + + + +++AT+SSE +
Sbjct: 1062 DEENSLGTEEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAE 1121
Query: 1148 IGAPAEGEQPEVEPEES----------------------LEPEACFTEDCVRKFKCCQIS 1185
AP GE PE E +PE CFTE CVR+ CC +
Sbjct: 1122 PQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVD 1181
Query: 1186 IEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYA 1245
+ GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYA
Sbjct: 1182 TTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYA 1241
Query: 1246 DKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSL 1305
DK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSL
Sbjct: 1242 DKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSL 1301
Query: 1306 RTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1365
RTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF
Sbjct: 1302 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1361
Query: 1366 CINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGW 1424
CIN T G++ + ++VNN S+C++L + + W VKVNFDNVG GYL+LLQVATFKGW
Sbjct: 1362 CINQTEGDLPLNYTIVNNKSQCESLNLTGE-LYWTKVKVNFDNVGAGYLALLQVATFKGW 1420
Query: 1425 MDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFG 1484
MDIMYAAVDSR E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK G
Sbjct: 1421 MDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLG 1480
Query: 1485 GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLN 1544
GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICLN
Sbjct: 1481 GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLN 1540
Query: 1545 MVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVIL 1604
MVTMMVETDDQS E NIL INL+F+ +FT
Sbjct: 1541 MVTMMVETDDQSPEKINILAKINLLFVAIFT----------------------------- 1571
Query: 1605 SIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1664
G L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIG
Sbjct: 1572 ---GTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIG 1628
Query: 1665 LLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPIL 1724
LLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PIL
Sbjct: 1629 LLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPIL 1688
Query: 1725 NSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATE 1784
N+GPP CDP + S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATE
Sbjct: 1689 NTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATE 1747
Query: 1785 ESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDL 1844
ES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL PL IAKPN++ LI MDL
Sbjct: 1748 ESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDL 1807
Query: 1845 PMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQ 1904
PMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1808 PMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKH 1867
Query: 1905 EEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST--- 1959
EEVSA++IQRA+RR+LL++ +K S ++++ G + P +E + ++EN +
Sbjct: 1868 EEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPL 1927
Query: 1960 -PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
P + ST+ PPSYDSVT+ + + D S ED
Sbjct: 1928 GPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 1967
>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
sapiens]
Length = 1956
Score = 2118 bits (5488), Expect = 0.0
Identities = 1144/2032 (56%), Positives = 1413/2032 (69%), Gaps = 179/2032 (8%)
Query: 12 DSFRFFTRESLAAIEQRIAEEKAKRPKQE--RKDEDDENGPKPNSDLEAGKSLPFIYGDI 69
++FR FT ESL IE++IA ++ + +E R+ +D E P+P DL+A LP YG++
Sbjct: 11 NNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGEL 70
Query: 70 PPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHS 129
P E++ PLEDLDP+Y +TF+VLNKG+ ISRFSAT AL++ +PFN IR+ AIK+ VHS
Sbjct: 71 PAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHS 130
Query: 130 LFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRD 189
F++ I TIL NCV MT ++ P+ +EY FT IYTFE+LIKILARGFCL +FT+LRD
Sbjct: 131 WFSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLRD 187
Query: 190 PWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLS 249
PWNWLDF+VIT AYV +DL +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL+
Sbjct: 188 PWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLA 247
Query: 250 DVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNR 309
DV ILT+FCLSVFAL+GLQLF GNL+NKC++ + +N T+ +++
Sbjct: 248 DVTILTIFCLSVFALVGLQLFKGNLKNKCVK-----NDMAVNETTNYSSHRKP------- 295
Query: 310 TVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDT 369
D YI + G +D LLCGN SD+G CP+GYIC+K NP++ YTSFD+
Sbjct: 296 -------DIYINKR-------GTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDS 341
Query: 370 FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYE 429
F+WAFLSLFRLMTQD WE LYQ TLR +GK YMIFFVLVIFLGSFYL+NLILAVV MAYE
Sbjct: 342 FAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYE 401
Query: 430 EQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSV 489
EQNQAT +E E KE +FQ+ LE L+K+QE A GI S S
Sbjct: 402 EQNQATTDEIEAKEKKFQEALEMLRKEQEVLAAL---------------GIDTTSLHSHN 446
Query: 490 ASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSRLTYE 549
S L+SK+ E + R K + E S E+ K+ R
Sbjct: 447 GSPLTSKNASE-RRHRIKPRVSEGSTEDNKSPR--------------------------- 478
Query: 550 KRFSSPH-QSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFE-DNDSR 607
S P+ Q +S G RR S S+F FR +DI DD F D++S
Sbjct: 479 ---SDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESH 533
Query: 608 RDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAG 667
R SL + G+ Q LP P N D + P T
Sbjct: 534 RGSLLLGGGAGQ-------QGPLPRSPLP-QPSNPDSRHGEDEHQP------PPT----S 575
Query: 668 QLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPP 727
+L P G + + ++ +S + L++P QRAMS+ SI+T+ +EELEES QKCPP
Sbjct: 576 ELAP-GAVDVSAFDAGQKKTF-LSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPP 633
Query: 728 CWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQF 787
C + LIWDCC W+K+K ++ +V DPF +L IT+CIV+NT+FMAMEH+ M+ F
Sbjct: 634 CLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTF 693
Query: 788 SSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLS 847
++L +GN+VFT FTAEM KIIA DPYYYFQ+ WNIFD IV++SL+ELG+A LS
Sbjct: 694 EAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLS 753
Query: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 907
VLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y
Sbjct: 754 VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENY 813
Query: 908 KECVCKISNDCE-LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMV 966
+ IS E PRWHMHDFFHSFLIVFR+LCGEWIE MW CMEV +++CL +F+ V
Sbjct: 814 RNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTV 873
Query: 967 MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQ 1026
MV+GNLVVLNLF+ALLL+SFS+DNL A +DD E+NNLQ+A+ R+Q K+ + F
Sbjct: 874 MVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFS 933
Query: 1027 KAFVRKQ-KALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKY 1085
++ Q KA E+ L++ K NH T G ++
Sbjct: 934 RSCPFPQPKAEPELVVKLPLSSSK---AENHIAA-------------NTARGSSGGLQAP 977
Query: 1086 VVDESDYMSFINNPSLTVTVPIAVGESDFENLNT-------------------------- 1119
++ FI NP++ V+VPIA GESD ++L
Sbjct: 978 RGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVE 1037
Query: 1120 -------------------------EEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEG 1154
E + ES + E ++ TSSSEGSTVD P E
Sbjct: 1038 RCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEI 1097
Query: 1155 EQPEVEPEESL-EPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETF 1213
+ E + L EP+ CFTE C+R CC++ + + W +RKTCY+IVEH+WFE+F
Sbjct: 1098 LRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESF 1157
Query: 1214 IVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNA 1273
I+FMILLSSG+LAFED Y++Q+ T+K +LEY D+VFT+IF+ EMLLKWVAYGF+ YFTNA
Sbjct: 1158 IIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNA 1217
Query: 1274 WCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGA 1333
WCWLDFLIV++SL+SLTA L YSE+ IK+LRTLRALRPLRALSRFEGMRVVV+AL+GA
Sbjct: 1218 WCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGA 1277
Query: 1334 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGE--MFDVSVVNNYSECKALIE 1391
IPSIMNVLLVCLIFWLIFSIMGVNLFAGKF+ CINYT GE + +S+VNN S+CK +
Sbjct: 1278 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCK-IQN 1336
Query: 1392 SNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYL 1451
S + W NVKVNFDNV +GYL+LLQVATFKGWMDIMYAAVDSR V +QPK+EDN+YMYL
Sbjct: 1337 STGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYL 1396
Query: 1452 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511
YFVIFIIFG FFTLNLF+GVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQK
Sbjct: 1397 YFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1456
Query: 1512 PIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFI 1571
PIPRP NKFQG VFD VT+Q FDI+IM+LICLNM+TMMVETDDQS+E T IL IN F+
Sbjct: 1457 PIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFV 1516
Query: 1572 VLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIE--KYFVSPTLFRVIR 1629
+FTGECV+K+ +LR YYFT GWN+FDF+VV+LSI + + +++ + + SPTLFRVIR
Sbjct: 1517 AVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIR 1576
Query: 1630 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREV 1689
LARIGRILRLI+ AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+ E
Sbjct: 1577 LARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEA 1636
Query: 1690 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNP 1749
GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+GPP CDP+ + + +GDCG+P
Sbjct: 1637 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPN-SNGTRGDCGSP 1695
Query: 1750 SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1809
+VGI FF +YIIISFL++VNMYIAVILENF+VATEES EPLSEDDF+MFYE WEKFDP+A
Sbjct: 1696 AVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEA 1755
Query: 1810 TQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGES 1869
TQFI F+ LSDFAD L PL I KPN+ LI MDLP+V GD+IHCLDILFAFTK VLGES
Sbjct: 1756 TQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGES 1815
Query: 1870 GEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVS 1929
GE+D+L+ MEE+FMA+N SK SYEPI TTL+ KQE++SA +IQ+AYR Y+L + + +
Sbjct: 1816 GELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSN 1875
Query: 1930 SIYKKDKGKECDGTPIKEDTLIDKLNENST-PEKTDMTPSTTSPPSYDSVTK 1980
+ +E P E + NEN P+K++ +T+ PPSY+SVT+
Sbjct: 1876 TPCVPRAEEEAASLP-DEGFVAFTANENCVLPDKSETASATSFPPSYESVTR 1926
>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
Length = 1836
Score = 1869 bits (4842), Expect = 0.0
Identities = 938/1257 (74%), Positives = 1067/1257 (84%), Gaps = 19/1257 (1%)
Query: 711 LTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIV 770
+++ MEELEE+ QKCPP WYK A+ LIW+CC PWLK K++++L+VMDPFVDL ITICIV
Sbjct: 530 ISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIV 589
Query: 771 LNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 830
LNTLFMAMEHYPMTE F +VL+VGNLVFTGIFTAEM LK+IAMDPY YFQ+GWNIFD I
Sbjct: 590 LNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSII 649
Query: 831 VSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 890
V+LSL+ELGLANV+GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI
Sbjct: 650 VTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 709
Query: 891 IVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDC 950
IVFIFAVVGMQLFGKSYKECVCKI+ DC LPRWHMHDFFHSFLIVFR+LCGEWIETMWDC
Sbjct: 710 IVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDC 769
Query: 951 MEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 1010
MEVAGQ MCLTVF+MVMVIGNLVVLNLFLALLLSSFS+D+LAA+D+D EMNNLQIA+GR+
Sbjct: 770 MEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRI 829
Query: 1011 QKGIDFVKRKIREFIQKAFVRKQK---ALDEIKPLEDLNNKKDSCISNHTTIEIGKDL-- 1065
+ GI F K + + + + +L E + ++ + +DL
Sbjct: 830 KLGIGFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKK 889
Query: 1066 -NYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSS 1124
N++ + G G SS+ E D+++FINNP LT+ VPIA ESD E EE +
Sbjct: 890 DNHILNHMGLADGPPSSL------ELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDT 943
Query: 1125 ESDMEESK---EKLNATSSSEGSTVDIGAPAEG--EQPEVEPEESLEPEACFTEDCVRKF 1179
S+ E+SK + L +SS ST D P E EQ E PE +PE CFTE CV+++
Sbjct: 944 FSEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGE-QPEECFTEACVQRW 1002
Query: 1180 KCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIK 1239
C + I +G+GK WW LR+ C+KIVEHNWFETFIVFMILLSSGALAFEDIYIEQR+ I+
Sbjct: 1003 PCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIR 1062
Query: 1240 TMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSEL 1299
T+LEYADKVFTYIFI+EMLLKWVAYGF+VYFTNAWCWLDFLIVDVS++SL AN LGYSEL
Sbjct: 1063 TILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSEL 1122
Query: 1300 GAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1359
G IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF
Sbjct: 1123 GPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1182
Query: 1360 AGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVA 1419
AGKFY+CIN TT E FD+S VNN SEC++L+ + Q RW NVKVN+DNVGLGYLSLLQVA
Sbjct: 1183 AGKFYYCINTTTSERFDISEVNNKSECESLMHTGQ-VRWLNVKVNYDNVGLGYLSLLQVA 1241
Query: 1420 TFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1479
TFKGWMDIMYAAVDSR E QP+YE NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ
Sbjct: 1242 TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1301
Query: 1480 KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMI 1539
KKK GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QGMV+D VTKQ FDI+IMI
Sbjct: 1302 KKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMI 1361
Query: 1540 LICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDF 1599
LICLNMVTMMVETD+QSQ +ILY IN++FI++FTGECVLK+++LR YYFT+GWNIFDF
Sbjct: 1362 LICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDF 1421
Query: 1600 VVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA 1659
VVVILSIVG+ L++LI+KYFVSPTLFRVIRLARIGR+LRLI+GAKGIRTLLFALMMSLPA
Sbjct: 1422 VVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPA 1481
Query: 1660 LFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGL 1719
LFNIGLLLFLVMFIY+IFGMSNFAYVK+E GIDDMFNFETFGNS+ICLF+ITTSAGWDGL
Sbjct: 1482 LFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGL 1541
Query: 1720 LAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779
L PILNSGPPDCDP+ ++PG+SVKGDCGNPS+GI FF SYIIISFL+VVNMYIA+ILENF
Sbjct: 1542 LNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENF 1601
Query: 1780 SVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQL 1839
+VATEES+EPL EDDFEMFYE WEKFDPDATQFI +++LSDF D L PL IAKPNK++L
Sbjct: 1602 NVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKL 1661
Query: 1840 IAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTT 1899
I +DLPMV GD+IHCLDILFA TK VLG+SGEMDAL+ MEE+FMA+NPSKVSYEPITTT
Sbjct: 1662 ITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTT 1721
Query: 1900 LKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNE 1956
LKRK EEV AI IQRAYRR+LL++ +K+ S +Y+ D P KE L + +++
Sbjct: 1722 LKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLANTMSK 1778
Score = 699 bits (1804), Expect = 0.0
Identities = 352/491 (71%), Positives = 407/491 (82%), Gaps = 21/491 (4%)
Query: 6 LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFI 65
LVP GP+ R FTRESLAAIEQR EE+A R ++ ++ E +E KP SDLEAGK+LP I
Sbjct: 9 LVPLGPECLRPFTRESLAAIEQRAVEEEA-RLQRNKQMEIEEPERKPRSDLEAGKNLPMI 67
Query: 66 YGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKI 125
YGD PPE++ +PLEDLDPYY NKKTFIVLNKGKAI RFSATPALY+L+PF+ +R+ AIK+
Sbjct: 68 YGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKV 127
Query: 126 LVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFT 185
L+H+LF+M IM TILTNCVFMTMS+PP W+KNVEYTFTGIYTFESLIKILARGFC++DFT
Sbjct: 128 LIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFT 187
Query: 186 FLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSV 245
FLRDPWNWLDF+VI AY+TEFVDLGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQSV
Sbjct: 188 FLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSV 247
Query: 246 KKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP----DNSSFEINITSFFNNSLD 301
KKLSDVMILTVFCLSVFAL+GLQLFMGNLR KC++WPP N+++ N T + N++
Sbjct: 248 KKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWY 307
Query: 302 GN-----------GTTFN-----RTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAG 345
GN T+N T F+WD YI D+ +FYFLEG NDALLCGNSSDAG
Sbjct: 308 GNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAG 367
Query: 346 QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFF 405
CPEGY C+K GRNPNYGYTS+DTFSWAFL+LFRLMTQD+WENL+QLTLRAAGKTYMIFF
Sbjct: 368 HCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFF 427
Query: 406 VLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAA 465
V++IFLGSFYLINLILAVVAMAY EQN+ATL E ++KE EFQQMLE+ KK QEE + A A
Sbjct: 428 VVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKA 487
Query: 466 AASAESRDFSG 476
A + E + G
Sbjct: 488 AQALEGGEADG 498
Score = 78.2 bits (191), Expect = 8e-14
Identities = 78/340 (22%), Positives = 147/340 (43%), Gaps = 80/340 (23%)
Query: 118 IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNV-----EYT---FTGIYTFE 169
+R+ KI+ H+ F I+ IL + + + + V EY FT I+ E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
Query: 170 SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT------EFVDLGNVSALRTFRVLR 223
L+K +A GF + + + W WLDF ++ + ++ + +LG + +LRT R LR
Sbjct: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
Query: 224 ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP 283
L+ +S G++ +V AL+ ++ + +V+++ + +F+++G+ LF G C+
Sbjct: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCI---- 1190
Query: 284 DNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSD 343
N TT R F+ E + +KS C +
Sbjct: 1191 -------------------NTTTSER----FDISE-VNNKSE------------CESLMH 1214
Query: 344 AGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK---- 399
GQ ++ VK ++D +LSL ++ T W ++ + + K
Sbjct: 1215 TGQV--RWLNVK---------VNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
Query: 400 -----TYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433
YM ++FV+ I GSF+ +NL + V+ + +Q +
Sbjct: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303
Score = 73.6 bits (179), Expect = 2e-12
Identities = 47/169 (27%), Positives = 87/169 (51%), Gaps = 18/169 (10%)
Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
+R+ K++ H F FI+ IL + + D + +EY FT I+ E
Sbjct: 120 VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
Query: 1257 MLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312
L+K +A GF V + + W WLDF ++ + A + +LG I +LRT R LR
Sbjct: 172 SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
Query: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
L+ ++ G++ +V AL+ ++ + +V+++ + +F+++G+ LF G
Sbjct: 226 ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
Score = 67.8 bits (164), Expect = 1e-10
Identities = 47/173 (27%), Positives = 86/173 (49%), Gaps = 12/173 (6%)
Query: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
P+ V+ V++ + I I I+ N +FM M P + FTGI+T
Sbjct: 116 PFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYT 169
Query: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
E +KI+A +D + + ++ WN D ++ ++ + ++ +S LR+FR+LR K
Sbjct: 170 FESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLT-EFVDLGNISALRTFRVLRALK 228
Query: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 911
P L ++ + SV L ++ ++ + +FA+VG+QLF G ++CV
Sbjct: 229 TITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCV 281
Score = 67.4 bits (163), Expect = 1e-10
Identities = 48/175 (27%), Positives = 89/175 (50%), Gaps = 16/175 (9%)
Query: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP--DWTKNV----EYTFTGIYT 167
P+ + + I++ ++ I I+ N +FM M + P + NV FTGI+T
Sbjct: 563 PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFT 622
Query: 168 FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNV---SALRTFRVLRA 224
E ++K++A ++ + + + WN D ++T + V + L NV S LR+FR+LR
Sbjct: 623 AEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLRV 676
Query: 225 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCL 279
K P L ++ + SV L ++ ++ + +FA++G+QLF G +C+
Sbjct: 677 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
Score = 38.1 bits (87), Expect = 0.087
Identities = 19/73 (26%), Positives = 44/73 (60%), Gaps = 2/73 (2%)
Query: 928 FFHSFLIVFRVLCGEWIETMWDC-MEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
F +FL +FR++ ++ E ++ + AG+T + F++++ +G+ ++NL LA++ ++
Sbjct: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMI-FFVVIIFLGSFYLINLILAVVAMAY 450
Query: 987 SSDNLAATDDDNE 999
+ N A +D E
Sbjct: 451 AEQNEATLAEDKE 463
Score = 36.2 bits (82), Expect = 0.33
Identities = 23/100 (23%), Positives = 46/100 (46%), Gaps = 10/100 (10%)
Query: 1404 NFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFF 1463
++D +L+L ++ T W ++ +L + YM ++FV+ I GSF+
Sbjct: 388 SYDTFSWAFLALFRLMTQDYWENLF---------QLTLRAAGKTYM-IFFVVIIFLGSFY 437
Query: 1464 TLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1503
+NL + V+ + +Q + +D EE ++ KK
Sbjct: 438 LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
Score = 33.9 bits (76), Expect = 1.6
Identities = 16/69 (23%), Positives = 38/69 (55%)
Query: 370 FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYE 429
F +FL +FR++ ++ E ++ A + F++V+ +G+ ++NL LA++ ++
Sbjct: 747 FFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFS 806
Query: 430 EQNQATLEE 438
+ A +E
Sbjct: 807 ADSLAASDE 815
>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
sapiens]
Length = 1682
Score = 1343 bits (3475), Expect = 0.0
Identities = 695/1292 (53%), Positives = 906/1292 (70%), Gaps = 40/1292 (3%)
Query: 667 GQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCP 726
G E T + E++KR S S+D+LED T R + EELE+S++ CP
Sbjct: 425 GNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKKICP 472
Query: 727 PCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQ 786
WYKFA LIW+C WLK+K V+ ++M PF DL + ICI+LN F+ +EHYPM++Q
Sbjct: 473 LYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQ 532
Query: 787 FSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGL 846
+++L++GNLVF GIFTAEM KIIAM PY YFQ GWNIFD IV L+EL LANV G+
Sbjct: 533 TNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGM 592
Query: 847 SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 906
++LR FR+LR+FKL K WPT +L+ + NS AL +L L+L +F A GM+LFGK+
Sbjct: 593 ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
Query: 907 YKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMV 966
Y+E VC I DC+LPRWHMHDFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+ ++MV
Sbjct: 653 YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMV 712
Query: 967 MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQ 1026
++IGNL+VL LFLAL+ SSFSS +++NE NLQ+AV R++KGI++V KI Q
Sbjct: 713 ILIGNLLVLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQ 771
Query: 1027 KAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYV 1086
++E+ ED IS+HT E+ ++LKD + S EK
Sbjct: 772 NVPKDTMDHVNEVYVKED--------ISDHTLSELSNTQDFLKDKEKS-----SGTEKNA 818
Query: 1087 VDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTV 1146
E++ S I +PS++ TVPIA GESD ENL+ +E S+S SKEK+ +SSSE STV
Sbjct: 819 T-ENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTV 877
Query: 1147 DIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVE 1206
DI A +E E+ E S C R QIS KGK+W N+RKTC KIVE
Sbjct: 878 DI-AISEEEEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVE 932
Query: 1207 HNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF 1266
+NWF+ FI + LLS+G LAFEDIY++QRKTIK +LEYAD +FTYIFILEMLLKW+AYGF
Sbjct: 933 NNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGF 992
Query: 1267 QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVV 1326
+ YF+N W LDF++V V +SL +K L +++ LRPLR LS+FE M+VV
Sbjct: 993 KAYFSNGWYRLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVV 1047
Query: 1327 VNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSEC 1386
V AL+ +NV LVCL+ WLIFSIMGV+LFAG+FY CI+ T+GE F S V N S C
Sbjct: 1048 VRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRC 1107
Query: 1387 KALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDN 1446
++L+ N++ W+N K+NFDNVG G+LSLLQVATF GW+ IM +A+DS V +QP +E N
Sbjct: 1108 ESLL-FNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVN 1166
Query: 1447 LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
+YMY YF+ FIIFG F L++ I VIIDNFN+ K K GG +IF+T +Q+K Y +KKL
Sbjct: 1167 IYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMY 1226
Query: 1507 KKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI 1566
+ Q+P+PRP NK QG +FD VT Q F++ +M+LIC + MM++TD QS +M+ LYWI
Sbjct: 1227 EDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWI 1286
Query: 1567 NLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFR 1626
N +F++L+T EC+LKLI+ R +YFTI WNIFDF+VVI SI G+ L + Y V P+L +
Sbjct: 1287 NSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQ 1346
Query: 1627 VIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 1686
+I L+RI +LRL KG K L+ LM+SLPAL NI LL+FLVMFIYA+FGM NFAYVK
Sbjct: 1347 LILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVK 1406
Query: 1687 REVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDC 1746
+E GI+D+ NFETFGNSM+CLFQ+ AGWDG+L I NS DCDPDK +PG+ V+GDC
Sbjct: 1407 KEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDC 1466
Query: 1747 GNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFD 1806
GNPSVGIF+FVSYI+IS+L++VNMYI V++E ++A+++ + LSEDDF F++VW++FD
Sbjct: 1467 GNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFD 1526
Query: 1807 PDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVL 1866
PD TQ+I+ +KLSDFA ALDPPL +AKPNK QLIA+DLPM GDRIHCLDIL AFTKRV+
Sbjct: 1527 PDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVM 1586
Query: 1867 GESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVK 1926
G+ M+ + ++E F+ +NP K++ EPITTTLKRKQE VSA IIQRAY+ Y L++ K
Sbjct: 1587 GQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDK 1646
Query: 1927 KVSSIYKKDKGKECDGTPIKEDTLIDKLNENS 1958
S I+ D ++ T KE DK E S
Sbjct: 1647 NTSDIHMIDGDRDVHAT--KEGAYFDKAKEKS 1676
Score = 422 bits (1086), Expect = e-117
Identities = 224/469 (47%), Positives = 301/469 (64%), Gaps = 29/469 (6%)
Query: 5 VLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPF 64
+L P P FT+ES I+Q IA K +D ++E+ KP DLE GK LPF
Sbjct: 1 MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEED-LKPTPDLEVGKKLPF 52
Query: 65 IYGDIPPEMVSVPLEDLDPYYINKK-TFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123
IYG++ MVS PLED+DPYY KK TFIVLNK + I RF+A L L+PFN IR+ I
Sbjct: 53 IYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTI 112
Query: 124 KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183
K+LVH F + I+ ++L +CVFM+++N P W +E T GIYTFE L+K+ ARG
Sbjct: 113 KVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGS 172
Query: 184 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
F+FL DPWNWLDF+V F + + L + L+T R LR LK I + GLK++VG LI
Sbjct: 173 FSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIH 232
Query: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
+K+L V+ILT+F LS+F+LIG+ LFMGNL++KC +WP +N N
Sbjct: 233 CLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENE----------------N 276
Query: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYG 363
T NRT + + YI + +FY+LEG+ ALLCGN +DAGQCPEGY+CVKAG NP+ G
Sbjct: 277 ETLHNRTGNPY----YIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQG 332
Query: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 423
+T+FD+F WA +LFRLM QD+ E LY L A+GK YMIFFV+V FL SFY+ +L L +
Sbjct: 333 FTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGI 392
Query: 424 VAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
+AMAYEE+ Q E +++ E +FQQ ++L++ E +A + R
Sbjct: 393 LAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKR 441
Score = 144 bits (362), Expect = 1e-33
Identities = 154/688 (22%), Positives = 294/688 (42%), Gaps = 142/688 (20%)
Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
+R+T K++ H +F+ FI+ +L+ ++ ++ + T+L ++T+ +++
Sbjct: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162
Query: 1257 MLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1316
+ + V G + + W WLDF + ++ + YS L I +L+T R LR L+
Sbjct: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
Query: 1317 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH----------- 1365
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G H
Sbjct: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276
Query: 1366 -CINYTTGEMFDVSVVNNY----SECKALIESNQTARWKNVK---------------VNF 1405
++ TG + + N+ E AL+ N+T + + NF
Sbjct: 277 ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336
Query: 1406 DNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTL 1465
D+ G +L ++ + + +++Y Q Y ++FV+ SF+
Sbjct: 337 DSFGWALFALFRLMA-QDYPEVLYH---------QILYASGKVYMIFFVVVSFLFSFYMA 386
Query: 1466 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1506
+LF+G++ + ++K++ G Q+ T+E K MKK
Sbjct: 387 SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446
Query: 1507 ------------------KKPQKPIPRPANKF----------------QGMVFDFVTKQV 1532
+K +K P KF + V +
Sbjct: 447 DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506
Query: 1533 FDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLR-YYYFT 1591
D+ ++I I LN+ + +E S++ +L NLVFI +FT E + K+I++ Y YF
Sbjct: 507 TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566
Query: 1592 IGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1651
+GWNIFD ++V ++ + LA + ++RL R+ RI +L K + L++
Sbjct: 567 VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618
Query: 1652 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--YVKREVGID-----DMFNFETFGNSM 1704
+L S AL ++ LLLF +F A FGM F Y + ID ++ F +S
Sbjct: 619 SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSF 678
Query: 1705 ICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISF 1764
+ +F+I + L + +G C P F++ I+I
Sbjct: 679 LNVFRILCGEWVETLWDCMEVAGQSWCIP---------------------FYLMVILIGN 717
Query: 1765 LVVVNMYIAVILENFSVATEESAEPLSE 1792
L+V+ +++A++ +FS + +AE +E
Sbjct: 718 LLVLYLFLALV-SSFSSCKDVTAEENNE 744
Score = 51.6 bits (122), Expect = 8e-06
Identities = 58/263 (22%), Positives = 120/263 (45%), Gaps = 26/263 (9%)
Query: 26 EQRIAEEKAK-RPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPY 84
+QR+ E K PK ++ ++ + G ++ + K++ P L+ L+
Sbjct: 401 KQRVGEISKKIEPKFQQTGKELQEG----NETDEAKTIQIEMKKRSPISTDTSLDVLEDA 456
Query: 85 YINKKTFIVLNKGKAIS-----RFSATPALYILTP-FNPIRKLAIKILVHSLFNMLIMCT 138
+ K L K K I +F+ T ++ +P + +++ +I++ ++ ++
Sbjct: 457 TLRHKE--ELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIIC 514
Query: 139 ILTNCVFMTMSNPP-----DWTKNV-EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWN 192
I+ N F+T+ + P + N+ F GI+T E + KI+A + + + + WN
Sbjct: 515 IILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGYFQVGWN 570
Query: 193 WLDFTVITFAYVTE--FVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSD 250
D ++I F + E ++ ++ LR FR+LR K P + ++ +L S L D
Sbjct: 571 IFD-SMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKD 629
Query: 251 VMILTVFCLSVFALIGLQLFMGN 273
+++L + A G++LF N
Sbjct: 630 LVLLLFTFIFFSAAFGMKLFGKN 652
Score = 49.3 bits (116), Expect = 4e-05
Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 13/164 (7%)
Query: 118 IRKLAIKILVHSLFNMLI-MCTILTNCVFMTMSNPPDWTKNV----EYT---FTGIYTFE 169
IRK KI+ ++ F I + T+L+ D K + EY FT I+ E
Sbjct: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
Query: 170 SLIKILARGFCLEDFTFLRDPWNWLDFTV-ITFAYVTEFVDLGNVSALRTFRVLRALKTI 228
L+K +A GF + + W LDF V I F + L + + LR L+ +
Sbjct: 983 MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
Query: 229 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
S +K +V ALI++ +V ++ + +F+++G+ LF G
Sbjct: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG 1082
Score = 48.5 bits (114), Expect = 6e-05
Identities = 38/164 (23%), Positives = 84/164 (51%), Gaps = 11/164 (6%)
Query: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
P+ ++ V++ PF L I I ++++ +FM++ + P ++ VL L GI+T
Sbjct: 103 PFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLP---KWRPVLENTLL---GIYT 156
Query: 804 AEMFLKIIAMD----PYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
E+ +K+ A + + + WN D F V++ + + + ++ + L++ R LR+ K
Sbjct: 157 FEILVKLFARGVWAGSFSFLGDPWNWLD-FSVTVFEVIIRYSPLDFIPTLQTARTLRILK 215
Query: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
+ L L+ ++ + + L + ++ + IF+++GM LF
Sbjct: 216 IIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259
Score = 40.4 bits (93), Expect = 0.018
Identities = 44/170 (25%), Positives = 78/170 (45%), Gaps = 29/170 (17%)
Query: 370 FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMI-FFVLVIFLGSFYLINLILAVVA--- 425
F +FL++FR++ ++ E L+ + AG+++ I F+++VI +G+ ++ L LA+V+
Sbjct: 674 FFHSFLNVFRILCGEWVETLWDC-MEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFS 732
Query: 426 ----MAYEEQNQA---TLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAG 478
+ EE N+A L A K+ +L+ L K Q ++ D
Sbjct: 733 SCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQN--------VPKDTMD----- 779
Query: 479 GIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSES 528
V +S + EL N + K KE+S EKN +S+S
Sbjct: 780 ----HVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQS 825
Score = 36.6 bits (83), Expect = 0.25
Identities = 36/175 (20%), Positives = 71/175 (40%), Gaps = 26/175 (14%)
Query: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFM---------TMSNPPDWTKNVEYTFTG 164
P N ++ ++ FN+++M I + M MS W ++ F
Sbjct: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSI---FVM 1292
Query: 165 IYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVDLGNVSA 215
+YT E ++K++A F FT WN DF V+ F+ + V V
Sbjct: 1293 LYTMECILKLIA--FRCFYFTI---AWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQL 1347
Query: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
+ R++ L+ ++ L+ S+ L ++++L + ++A+ G+ F
Sbjct: 1348 ILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF 1402
>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
sapiens]
Length = 1791
Score = 1302 bits (3370), Expect = 0.0
Identities = 704/1334 (52%), Positives = 929/1334 (69%), Gaps = 98/1334 (7%)
Query: 663 LTSAGQLLPEGTTTETEIRKR-------RSSSYHVSMDLLE---DPTSRQRAMSIASILT 712
L +G+ P G+ ++ + +K+ + S ++S+D + DP RQRA+S SILT
Sbjct: 471 LRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILT 530
Query: 713 NTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLN 772
TM+E E+S++ C PC A+ L+W+CC WL VK ++ V+ DPF +LAITICI++N
Sbjct: 531 ITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIIN 590
Query: 773 TLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVS 832
T+F+AMEH+ M F +L++GNLVFT IF AEM LKIIA+DPY+YF+ GWNIFD +
Sbjct: 591 TVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVAL 650
Query: 833 LSLMELGLANVEGLS--VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 890
LS ++ ++ S LRSFR+LRVFKLAKSWPTLN LIKIIGNSVGALG+LT+VL I
Sbjct: 651 LSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVI 710
Query: 891 IVFIFAVVGMQLFGKSYKECVC-KISNDCE-----LPRWHMHDFFHSFLIVFRVLCGEWI 944
++FIF+VVGMQLFG+S+ K+ N L WHM DF+HSFL+VFR+LCGEWI
Sbjct: 711 VIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWI 770
Query: 945 ETMWDCMEVAG--QTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAAT-DDDNEMN 1001
E MW+CM+ A ++C+ VF+++ VIG LVVLNLF+ALLL+SFS++ + +
Sbjct: 771 ENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKT 830
Query: 1002 NLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEI 1061
+Q+A+ R ++ FV+ + F K + RKQ L C + +I
Sbjct: 831 KVQLALDRFRRAFCFVRHTLEHFCHK-WCRKQN-------LPQQKEVAGGCAAQSK--DI 880
Query: 1062 GKDLNYLKDGNGTTSGIG--SSVEKYV------------VDESDYMSFINNPSLT-VTVP 1106
+ +K G+ T +G +SV K + +E D + F + +T P
Sbjct: 881 IPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQP 940
Query: 1107 IAVGES-------------DFENLNTEEFSSESD---MEESKEKLNATSS-SEGSTVDIG 1149
++ +++ + FS + +++ ++K + TS SE ST+D+
Sbjct: 941 EPEQQAYELHQENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDL- 999
Query: 1150 APAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNW 1209
G PE+ P++ +PE C + F CC + + +WWNLRKTCY+IV+H+W
Sbjct: 1000 QDGFGWLPEMVPKK--QPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSW 1057
Query: 1210 FETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVY 1269
FE+FI+F+ILLSSGAL FED+++E + I+ +L D +FT+IFILEM+LKWVA+GF Y
Sbjct: 1058 FESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKY 1117
Query: 1270 FTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1329
FT+AWC LDF+IV VS+ +L L +KS RTLRALRPLRALS+FEGM+VVVNA
Sbjct: 1118 FTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNA 1170
Query: 1330 LLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL 1389
L+GAIP+I+NVLLVCLIFWL+F I+GV F+GKF CIN T + + +++ N S+C++
Sbjct: 1171 LIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCIN-GTDSVINYTIITNKSQCES- 1228
Query: 1390 IESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYM 1449
W N KVNFDNVG YL+LLQVATFKGWMDI+YAAVDS E QP++E N
Sbjct: 1229 ----GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLG 1284
Query: 1450 YLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1509
Y+YFV+FIIFGSFFTLNLFIGVIIDNFNQQ+KK GGQDIFMTEEQKKYYNAMKKLGSKKP
Sbjct: 1285 YIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKP 1344
Query: 1510 QKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
QKPIPRP NK QG+VFD VT Q+FDI I+ LI LNM++MM E+ +Q + M +IL +N V
Sbjct: 1345 QKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWV 1404
Query: 1570 FIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV--SPTLFRV 1627
F+V+FT EC++K+ +LR YYFT GWN+FD VVV+LSIV ++ L + + PTLFR+
Sbjct: 1405 FVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRI 1464
Query: 1628 IRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
+RLARIGRILRL++ A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIYAI GM+ F+ V
Sbjct: 1465 VRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNP 1524
Query: 1688 EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCG 1747
E GIDD+FNF+TF +SM+CLFQI+TSAGWD LL+P+L S K+ SS + +C
Sbjct: 1525 ESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRS--------KESCNSSSE-NCH 1575
Query: 1748 NPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDP 1807
P + +FVSYIIISFL+VVNMYIAVILENF+ ATEES +PL EDDF++FYEVWEKFDP
Sbjct: 1576 LPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDP 1635
Query: 1808 DATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLG 1867
+ATQFI+++ LSDFADAL PL +AKPNK Q + MDLPMVS DR+HC+DILFAFT RVLG
Sbjct: 1636 EATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLG 1695
Query: 1868 ESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKK 1927
S +D+++ MEE+FM +NP K YEPI TT KRK+EE A IIQ+A+R+Y++K
Sbjct: 1696 GSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK----- 1750
Query: 1928 VSSIYKKDKGKECD 1941
+ K D+G + D
Sbjct: 1751 ---VTKGDQGDQND 1761
Score = 406 bits (1044), Expect = e-113
Identities = 243/532 (45%), Positives = 317/532 (59%), Gaps = 56/532 (10%)
Query: 9 PGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGD 68
P +FR FT +SLAAIE+RIA +K K+ +++ E + P+P DL+A + LP +YGD
Sbjct: 11 PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQ--PRPQLDLKASRKLPKLYGD 68
Query: 69 IPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVH 128
IP E++ PLEDLDP+Y N KTF+VLN+ + I RFSA AL+I PFN IR LAI++ VH
Sbjct: 69 IPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVH 128
Query: 129 SLFNMLIMCTILTNCVFMTMSNPPDWTKN----VEYTFTGIYTFESLIKILARGFCLEDF 184
SLF+M I+ T++ NCVFM + N E FTGIY FE+LIKILARGF L++F
Sbjct: 129 SLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEF 188
Query: 185 TFLRDPWNWLDFTVITFAYVTEFVDLG-NVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
+FLRDPWNWLD VI A V+ + + LRTFRV RALK ISV+ LK IVGAL++
Sbjct: 189 SFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248
Query: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
SVKKL +V+ILT FCLS+FAL+G QLFMG+L KC+ N S
Sbjct: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNIS---------------- 292
Query: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYG 363
+ +D E K E + +CG C Y C NP+Y
Sbjct: 293 --------NPEAYDHCFEKK------ENSPEFKMCGIWMGNSACSIQYECKHTKINPDYN 338
Query: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 423
YT+FD F W+FL++FRLMTQD WE LYQ TLR G + FF++VIFLGSFYLINL LAV
Sbjct: 339 YTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAV 398
Query: 424 VAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVF 483
V MAYEEQN+ E E KE FQ+ +QL K+++EA A GI
Sbjct: 399 VTMAYEEQNKNVAAEIEAKEKMFQE-AQQLLKEEKEALVAM--------------GIDRS 443
Query: 484 SESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRK 535
S +S S + K K N+++K +SG+ D+ S+S++ ++K
Sbjct: 444 SLTSLETSYFTPKKRKLFGNKKRKSFFLRESGK----DQPPGSDSDEDCQKK 491
Score = 115 bits (287), Expect = 6e-25
Identities = 158/799 (19%), Positives = 308/799 (38%), Gaps = 154/799 (19%)
Query: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
P+ ++ L V + + I +++N +FMA P S+ + VFTGI+
Sbjct: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG--PAKNSNSNNTDIAECVFTGIYI 171
Query: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
E +KI+A +D + + ++ WN D ++ ++++ L LR+FR+ R K
Sbjct: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALK 231
Query: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF---------------- 903
L +++ + SV L N+ ++ + IFA+VG QLF
Sbjct: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNI 291
Query: 904 --GKSYKEC--------------------VCKISNDCELPR-------WHMHDFFHSFLI 934
++Y C C I +C+ + + +F SFL
Sbjct: 292 SNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLA 351
Query: 935 VFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAAT 994
+FR++ + E ++ + F++V+ +G+ ++NL LA++ ++ N
Sbjct: 352 MFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQN---- 407
Query: 995 DDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEI-----KPLEDLNNKK 1049
N ++ Q+ +K + + R E K + NKK
Sbjct: 408 --KNVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKK 465
Query: 1050 DSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAV 1109
+ E GKD G+ S + +++++ +S
Sbjct: 466 R---KSFFLRESGKD-----QPPGSDSDEDCQKKPQLLEQTKRLS--------------- 502
Query: 1110 GESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEA 1169
+NL+ + F D + + L+A S T+ + E E+S EP
Sbjct: 503 -----QNLSLDHFDEHGDPLQRQRALSAVSI---LTITM----------KEQEKSQEPCL 544
Query: 1170 CFTEDCVRKF---KCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALA 1226
E+ K+ CC W ++K ++ + E I I++++ LA
Sbjct: 545 PCGENLASKYLVWNCC---------PQWLCVKKVLRTVMTDPFTELAITICIIINTVFLA 595
Query: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSL 1286
E + + + + ML + VFT IFI EM LK +A YF W D ++ +S
Sbjct: 596 ME--HHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
Query: 1287 VSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1346
+ L ++S R LR + ++ + ++ +GA+ S + V+LV +I
Sbjct: 654 ADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-LTVVLVIVI 712
Query: 1347 FWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTA----RWKNVK 1402
F IFS++G+ LF F N+ K + T W
Sbjct: 713 F--IFSVVGMQLFGRSF-----------------NSQKSPKLCNPTGPTVSCLRHW---- 749
Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
+ + +L + ++ + W++ M+ + N + + F++ + G
Sbjct: 750 -HMGDFWHSFLVVFRILCGE-WIENMWECMQEANA-------SSSLCVIVFILITVIGKL 800
Query: 1463 FTLNLFIGVIIDNFNQQKK 1481
LNLFI +++++F+ +++
Sbjct: 801 VVLNLFIALLLNSFSNEER 819
Score = 100 bits (249), Expect = 1e-20
Identities = 78/338 (23%), Positives = 147/338 (43%), Gaps = 47/338 (13%)
Query: 1196 NLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1255
++R ++ H+ F FI+ ++++ +A + + + A+ VFT I+I
Sbjct: 117 SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIF 172
Query: 1256 EMLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1311
E L+K +A GF + + + W WLD +++ +++VS + LRT R
Sbjct: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227
Query: 1312 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF------YH 1365
R L+A+S ++V+V ALL ++ ++NV+++ IF+++G LF G
Sbjct: 228 RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRD 287
Query: 1366 CINYTTGEMFD--------------VSVVNNYSECKALIESNQTARWKNVK-VNFDNVGL 1410
C N + E +D + S C E T + NFDN G
Sbjct: 288 CKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGW 347
Query: 1411 GYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIG 1470
+L++ ++ T W + Q LY +F++ I GSF+ +NL +
Sbjct: 348 SFLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397
Query: 1471 VIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1508
V+ + +Q K + + ++K + A + L +K
Sbjct: 398 VVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
Score = 77.8 bits (190), Expect = 1e-13
Identities = 79/334 (23%), Positives = 137/334 (41%), Gaps = 80/334 (23%)
Query: 118 IRKLAIKILVHSLFNMLIMCTILTNC---VF--MTMSNPPDWTKNVEYT---FTGIYTFE 169
+RK +I+ HS F I+ IL + +F + + N P + + T FT I+ E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
Query: 170 SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTIS 229
++K +A GF + W LDF +I VT ++L + + RT R LR L+ +S
Sbjct: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159
Query: 230 VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFE 289
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+ + +
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI----NGTDSV 1214
Query: 290 INITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPE 349
IN T N S +G F+W I K +F
Sbjct: 1215 INYTIITNKSQCESGN--------FSW---INQKVNF----------------------- 1240
Query: 350 GYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM------- 402
D A+L+L ++ T W ++ + + K
Sbjct: 1241 ------------------DNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNS 1282
Query: 403 ---IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433
I+FV+ I GSF+ +NL + V+ + +Q +
Sbjct: 1283 LGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316
Score = 59.3 bits (142), Expect = 4e-08
Identities = 47/184 (25%), Positives = 85/184 (46%), Gaps = 22/184 (11%)
Query: 104 SATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMS--NPPDWTKNV--- 158
S P I P N + L I+ +F+++I+ I+ N + M N P K++
Sbjct: 1341 SKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDH 1400
Query: 159 -EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD-LGN---- 212
+ F I+T E LIKI F L + F + WN D V+ + V+ + L N
Sbjct: 1401 LNWVFVVIFTLECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHI 1455
Query: 213 ------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIG 266
+R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G
Sbjct: 1456 PFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILG 1515
Query: 267 LQLF 270
+ F
Sbjct: 1516 MNWF 1519
Score = 58.5 bits (140), Expect = 6e-08
Identities = 45/162 (27%), Positives = 78/162 (48%), Gaps = 13/162 (8%)
Query: 118 IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP-----DWTKNV-EYTFTGIYTFESL 171
++K+ ++ + I I+ N VF+ M + + N+ FT I+ E
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
Query: 172 IKILARGFCLEDFTFLRDPWNWLDFTV--ITFAYVTEFV-DLGNVSALRTFRVLRALKTI 228
+KI+A L+ + + R WN D V ++FA V V + LR+FRVLR K
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
Query: 229 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
P L T++ + SV L + ++ V + +F+++G+QLF
Sbjct: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
Score = 44.3 bits (103), Expect = 0.001
Identities = 67/368 (18%), Positives = 131/368 (35%), Gaps = 97/368 (26%)
Query: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFT 1575
P N + + +F + I+ + +N V M T +N VF ++
Sbjct: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMA--TGPAKNSNSNNTDIAECVFTGIYI 171
Query: 1576 GECVLKLISL-----RYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1630
E ++K+++ + + WN D +V+ ++IV I+ +R
Sbjct: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRT 223
Query: 1631 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS------NFAY 1684
R+ R L+ I ++ ++ AL+ S+ L N+ +L F + I+A+ G N
Sbjct: 224 FRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC 283
Query: 1685 VKREV-------GIDDMF---------------------------------------NFE 1698
+ R+ D F NF+
Sbjct: 284 ISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFD 343
Query: 1699 TFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVS 1758
FG S + +F++ T W+ L L + +FFF+
Sbjct: 344 NFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFIV 382
Query: 1759 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKL 1818
I + ++N+ +AV+ ++A EE + ++ + E EK +A Q ++ K
Sbjct: 383 VIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEKE 433
Query: 1819 SDFADALD 1826
+ A +D
Sbjct: 434 ALVAMGID 441
Score = 39.7 bits (91), Expect = 0.030
Identities = 19/88 (21%), Positives = 49/88 (55%), Gaps = 2/88 (2%)
Query: 370 FSWAFLSLFRLMTQDFWENLYQLT--LRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMA 427
F +FL +FR++ ++ EN+++ A+ +I F+L+ +G ++NL +A++ +
Sbjct: 754 FWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNS 813
Query: 428 YEEQNQATLEEAEQKEAEFQQMLEQLKK 455
+ + + E E ++ + Q L++ ++
Sbjct: 814 FSNEERNGNLEGEARKTKVQLALDRFRR 841
Score = 33.1 bits (74), Expect = 2.8
Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 27/122 (22%)
Query: 359 NPNYGYT---SFDTFSWAFLSLFRLMTQDFWENLYQLTLRA---------------AGKT 400
NP G +F TF+ + L LF++ T W++L LR+ +
Sbjct: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
Query: 401 YMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK--EAEFQQMLEQLKKQQE 458
Y + ++++ FL ++N+ +AV+ E N AT EE+E E +F E +K
Sbjct: 1583 YFVSYIIISFL---IVVNMYIAVI---LENFNTAT-EESEDPLGEDDFDIFYEVWEKFDP 1635
Query: 459 EA 460
EA
Sbjct: 1636 EA 1637
>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
type V, alpha (long QT syndrome 3) [Homo sapiens]
Length = 1637
Score = 1018 bits (2632), Expect = 0.0
Identities = 544/853 (63%), Positives = 633/853 (74%), Gaps = 72/853 (8%)
Query: 974 VLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREF---IQKAFV 1030
VLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+Q+G+ FVKR +F + +
Sbjct: 631 VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
Query: 1031 RKQKALDEIKPLEDLNNKKDSCISNH------TTIEIGKDLNYLKDGNGTTSGIGSSVEK 1084
+K AL + SCI+ T ++ + G G G+
Sbjct: 691 QKPAALAA-------QGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTP--- 740
Query: 1085 YVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGS 1144
+P V VPIAV ESD ++ +E +S EES ++ + S G
Sbjct: 741 ------------GDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGG- 786
Query: 1145 TVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKI 1204
PE P+ + T + S + + W
Sbjct: 787 ------------PEAPPDSRTWSQVSATASSE-----AEASASQADWRQQWKAEPQAPGC 829
Query: 1205 VEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAY 1264
E AFEDIY+E+RKTIK +LEYADK+FTY+F+LEMLLKWVAY
Sbjct: 830 GE-------------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 870
Query: 1265 GFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMR 1324
GF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRALRPLRALSRFEGMR
Sbjct: 871 GFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMR 930
Query: 1325 VVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEM-FDVSVVNNY 1383
VVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF CIN T G++ + ++VNN
Sbjct: 931 VVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNK 990
Query: 1384 SECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKY 1443
S+C++L + + W VKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR E QP++
Sbjct: 991 SQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1049
Query: 1444 EDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1503
E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKK
Sbjct: 1050 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1109
Query: 1504 LGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNIL 1563
LGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICLNMVTMMVETDDQS E NIL
Sbjct: 1110 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1169
Query: 1564 YWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPT 1623
INL+F+ +FTGEC++KL +LR+YYFT WNIFDFVVVILSIVG L+++I+KYF SPT
Sbjct: 1170 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1229
Query: 1624 LFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1683
LFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFA
Sbjct: 1230 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
Query: 1684 YVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVK 1743
YVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+GPP CDP + S +
Sbjct: 1290 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-R 1348
Query: 1744 GDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWE 1803
GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WE
Sbjct: 1349 GDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWE 1408
Query: 1804 KFDPDATQFIEFA 1816
KFDP+ATQFIE++
Sbjct: 1409 KFDPEATQFIEYS 1421
Score = 683 bits (1763), Expect = 0.0
Identities = 384/672 (57%), Positives = 462/672 (68%), Gaps = 65/672 (9%)
Query: 6 LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
L+P G SFR FTRESLAAIE+R+AE++A+ ++ R+ +E P+P DL+A K L
Sbjct: 5 LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
Query: 63 PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
P +YG+ P E++ PLEDLDP+Y +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65 PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
Query: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
+KILVHSLFNMLIMCTILTNCVFM +PP WTK VEYTFT IYTFESL+KILARGFCL
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
Query: 183 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
FTFLRDPWNWLDF+VI AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
Query: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++ N T+ N S+
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
+ +G + + D Y+ D ++ G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
LAVVAMAYEEQNQAT+ E E+KE FQ+ +E LKK+ E G+
Sbjct: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
S SS S L+ + E RR K++++ SG EE DR+ KS+SED R
Sbjct: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPR------ 504
Query: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
+ H SL R+SR S+F+FR R D+GSE DFADDE+S
Sbjct: 505 -------------AMNHLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
Query: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
T +++S SL VP RR S Q S + P ++GK +S VDCNGVVSL+G
Sbjct: 550 TAGESESHHTSLLVP--WPLRRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
Query: 659 GPSTLTSAGQLL 670
G TS G L
Sbjct: 607 GDPEATSPGSHL 618
Score = 93.2 bits (230), Expect = 2e-18
Identities = 83/350 (23%), Positives = 155/350 (44%), Gaps = 70/350 (20%)
Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
+R+ KI+ H+ F I+ IL + +A D +Y + FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
Query: 1257 MLLKWVAYGFQVY-FT---NAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312
L+K +A GF ++ FT + W WLDF ++ + A + +LG + +LRT R LR
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
Query: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH------- 1365
L+ +S G++ +V AL+ ++ + +V+++ + +F+++G+ LF G H
Sbjct: 226 ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
Query: 1366 CINYTTGEM--------------------------FDVSVVNNYSECKALIESNQTARW- 1398
+N T G + DV + N S+ E + +
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
Query: 1399 ---KNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVI 1455
+ +FD+ +L+L ++ T W + + S +YM ++F++
Sbjct: 346 ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
Query: 1456 FIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1504
I GSF+ +NL + V+ + +Q + I TEE +K++ AM+ L
Sbjct: 396 VIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
Score = 84.0 bits (206), Expect = 1e-15
Identities = 69/285 (24%), Positives = 134/285 (47%), Gaps = 40/285 (14%)
Query: 743 KPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIF 802
+P K + + +V D+ I I LN + M +E + + ++L+ NL+F IF
Sbjct: 1121 RPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIF 1180
Query: 803 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANV--------EGLSVLRSFRL 854
T E +K+ A+ +YYF WNIFD +V LS++ L+++ V+R R+
Sbjct: 1181 TGECIVKLAAL-RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARI 1239
Query: 855 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 914
R+ +L + + L+ + S+ AL N+ L+L +++FI+++ GM F +Y + I
Sbjct: 1240 GRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGI 1297
Query: 915 SNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC--------------- 959
+ ++ F +S L +F++ + + + G C
Sbjct: 1298 DD-----MFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCG 1352
Query: 960 -----LTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNE 999
+ F ++I L+V+N+++A++L +FS AT++ E
Sbjct: 1353 SPAVGILFFTTYIIISFLIVVNMYIAIILENFS----VATEESTE 1393
Score = 76.3 bits (186), Expect = 3e-13
Identities = 64/288 (22%), Positives = 122/288 (42%), Gaps = 71/288 (24%)
Query: 162 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT------EFVDLGNVSA 215
FT ++ E L+K +A GF + + W WLDF ++ + V+ F ++G + +
Sbjct: 855 FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910
Query: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275
LRT R LR L+ +S G++ +V AL+ ++ + +V+++ + +F+++G+ LF G
Sbjct: 911 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969
Query: 276 NKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDA 335
+C+ +N T N S + N T ++ W +
Sbjct: 970 GRCIN--QTEGDLPLNYTIVNNKS---QCESLNLTGELY-WTK----------------- 1006
Query: 336 LLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR 395
VK +FD +L+L ++ T W ++ +
Sbjct: 1007 ------------------VK---------VNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1039
Query: 396 AAG---------KTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433
+ G YM I+FV+ I GSF+ +NL + V+ + +Q +
Sbjct: 1040 SRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087
Score = 64.7 bits (156), Expect = 9e-10
Identities = 58/284 (20%), Positives = 118/284 (41%), Gaps = 48/284 (16%)
Query: 790 VLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL-----GLANVE 844
+L + +FT +F EM LK +A YF W D IV +SL+ L G A +
Sbjct: 847 LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
Query: 845 GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 904
+ LR+ R LR + + + +++ + ++ ++ N+ LV I IF+++G+ LF
Sbjct: 907 PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
Query: 905 KSYKECVCKISNDCEL------------------------PRWHMHDFFHSFLIVFRVLC 940
+ C+ + D L + + + +L + +V
Sbjct: 967 GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
Query: 941 GE-WIETMWDCMEVAG---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS--- 987
+ W++ M+ ++ G F++ ++ G+ LNLF+ +++ +F+
Sbjct: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
Query: 988 ----SDNLAATDDDNEMNNLQIAVG--RMQKGIDFVKRKIREFI 1025
++ T++ + N +G + QK I K + FI
Sbjct: 1087 KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130
Score = 58.9 bits (141), Expect = 5e-08
Identities = 42/173 (24%), Positives = 81/173 (46%), Gaps = 12/173 (6%)
Query: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
P+ ++ +++ ++ I I+ N +FMA P ++ FT I+T
Sbjct: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYT 169
Query: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
E +KI+A + + + ++ WN D F V + ++ +S LR+FR+LR K
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLD-FSVIIMAYTTEFVDLGNVSALRTFRVLRALK 228
Query: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 911
L ++ + SV L ++ ++ + +FA++G+QLF G +CV
Sbjct: 229 TISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281
Score = 38.5 bits (88), Expect = 0.067
Identities = 24/120 (20%), Positives = 57/120 (47%), Gaps = 6/120 (5%)
Query: 928 FFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987
F +FL +FR++ + E ++ + + + FM+V+ +G+ ++NL LA++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 988 SDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNN 1047
N A + E R Q+ ++ +K++ + ++ E+ PL +N+
Sbjct: 418 EQNQATIAETEEKEK------RFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform c [Homo sapiens]
Length = 2137
Score = 426 bits (1095), Expect = e-118
Identities = 332/1146 (28%), Positives = 555/1146 (48%), Gaps = 175/1146 (15%)
Query: 765 ITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWN 824
+ + + LNTL ++ EHY + + + + N V +FT EM +K+ ++ YF +N
Sbjct: 529 VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588
Query: 825 IFDGFIVSLSLMELGLANVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 879
FD F+V + E L +E G+SV R RLLR+FK+ + W +L+ L+ + NS+
Sbjct: 589 RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 648
Query: 880 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVL 939
++ +L L+L + + IF+++GMQLFG + ++ + R +F + L VF++L
Sbjct: 649 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 702
Query: 940 CGE-WIETMWDCM------EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLA 992
GE W M+D + +G +C+ F+++ + GN ++LN+FLA+ + DNLA
Sbjct: 703 TGEDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAV-----DNLA 756
Query: 993 ATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSC 1052
D +N Q K + E +K RK E L NKK++
Sbjct: 757 ---DAESLNTAQ-------------KEEAEEKERKKIARK----------ESLENKKNN- 789
Query: 1053 ISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGES 1112
+ I +S K +D+ +P VP VGE
Sbjct: 790 -------------------KPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVP--VGE- 827
Query: 1113 DFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFT 1172
EE +E+ E EPE P
Sbjct: 828 ----------------EEEEEE-----------------------EDEPEVPAGPRPRRI 848
Query: 1173 EDCVRKFKCCQISIEEGKGKLWWNLRKT------CYKIVEHNWFETFIVFMILLSSGALA 1226
+ K K I +G ++ L KT C+K++ H+ F I+ I+LSS ALA
Sbjct: 849 SELNMKEKIAPIP----EGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 904
Query: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF----QVYFTNAWCWLDFLIV 1282
ED I T+L Y D FT IF +E+LLK +G + N + LD L+V
Sbjct: 905 AED-PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 963
Query: 1283 DVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLL 1342
VSLVS + S + +K LR LR LRPLRA++R +G++ VV + AI +I N+++
Sbjct: 964 GVSLVSF---GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020
Query: 1343 VCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL--------IESNQ 1394
V + +F+ +GV LF GKFY C + +N EC+ L ++S
Sbjct: 1021 VTTLLQFMFACIGVQLFKGKFYRCTD---------EAKSNPEECRGLFILYKDGDVDSPV 1071
Query: 1395 TAR--WKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLY 1452
W+N NFDNV ++L V+TF+GW ++Y A+DS + P Y + + ++
Sbjct: 1072 VRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIF 1131
Query: 1453 FVIFIIFGSFFTLNLFIGVIIDNFNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511
F+I+II +FF +N+F+G +I F +Q +K++ ++ + Q Y A+K +
Sbjct: 1132 FIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------AR 1183
Query: 1512 PIPR--PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
P+ R P N +Q + V F+ + +LI LN + + ++ +QS+ + + +N+V
Sbjct: 1184 PLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMV 1243
Query: 1570 FIVLFTGECVLKLISLR-YYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628
F +FT E VLK+I+ + YF+ WN FD ++VI SI+ + L+E +
Sbjct: 1244 FTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFF 1303
Query: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV--K 1686
RL R+ R+++L+ +GIRTLL+ + S AL + LL+ ++ FIYA+ GM F V +
Sbjct: 1304 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMR 1363
Query: 1687 REVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDH-PGSSVKGD 1745
I+ NF+TF +++ LF+ T W ++ L CDP+ D+ PG
Sbjct: 1364 DNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPG--KLCDPESDYNPGEEY--T 1419
Query: 1746 CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF 1805
CG+ + I +F+S+ ++ +++N+++AVI++NF T + + L + F +W ++
Sbjct: 1420 CGS-NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFKRIWSEY 1477
Query: 1806 DPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFA 1860
DP+A I+ + + PPL K P++V +L+AM++P+ S + LFA
Sbjct: 1478 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFA 1537
Query: 1861 FTKRVL 1866
+ L
Sbjct: 1538 LVRTAL 1543
Score = 147 bits (372), Expect = 8e-35
Identities = 107/376 (28%), Positives = 180/376 (47%), Gaps = 73/376 (19%)
Query: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-PDWTKN--------V 158
AL+ L+ NPIR+ I I+ F++ I+ I NCV + + P P+ N V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164
Query: 159 EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAY-------VTEFVDLG 211
EY F I+T E+ +KI+A G L ++R+ WN LDF ++ +T+ + G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224
Query: 212 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 261
N V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Query: 262 FALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIE 321
+A+IGL+LF+G + C FF +S
Sbjct: 285 YAIIGLELFIGKMHKTC----------------FFADS---------------------- 306
Query: 322 DKSHFYFLEGQNDALLCGNSSDAGQC-PEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRL 380
+ + D C S + QC G C PN G T+FD F++A L++F+
Sbjct: 307 ------DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
Query: 381 MTQDFWEN-LYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAY-EEQNQATLEE 438
+T + W + LY + + ++FV ++ GSF+++NL+L V++ + +E+ +A
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 439 AEQKEAEFQQMLEQLK 454
QK E QQ+ E LK
Sbjct: 421 DFQKLREKQQLEEDLK 436
Score = 137 bits (346), Expect = 8e-32
Identities = 98/328 (29%), Positives = 157/328 (47%), Gaps = 41/328 (12%)
Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI----EQRKTIKTMLEYADKVFTYI 1252
+R+ C IVE F+ FI+ I + ALA IYI + + LE + F I
Sbjct: 115 IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 1253 FILEMLLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGA------- 1301
F +E LK +AYG Y N W LDF+IV V L S+ L G
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 1302 ----IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1357
+K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 1358 LFAGKFYHCINYTTGEMF------DVSVVNNYSECKALIESNQTARWKNVK---VNFDNV 1408
LF GK + + ++ + N +C A + + W NFDN
Sbjct: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTA-NGTECRSGWVGPNGGITNFDNF 350
Query: 1409 GLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLF 1468
L++ Q T +GW D++Y D+ EL ++YFV +IFGSFF LNL
Sbjct: 351 AFAMLTVFQCITMEGWTDVLYWMNDAMGFELP---------WVYFVSLVIFGSFFVLNLV 401
Query: 1469 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
+GV+ F+++++K + F +K+
Sbjct: 402 LGVLSGEFSKEREKAKARGDFQKLREKQ 429
Score = 126 bits (317), Expect = 2e-28
Identities = 78/258 (30%), Positives = 133/258 (51%), Gaps = 31/258 (12%)
Query: 754 LVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAM 813
+V PF + + + I+LNTL +AM+HY ++ F+ + + N+VFTG+FT EM LK+IA
Sbjct: 1201 VVNSSPF-EYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1259
Query: 814 DPYYYFQEGWNIFDGFIVSLSLMELGLANVE--------GLSVLRSFRLLRVFKLAKSWP 865
P YF + WN FD IV S++++ L+ + ++ R FR++R+ KL
Sbjct: 1260 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGE 1319
Query: 866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHM 925
+ L+ S AL + L++A++ FI+AV+GMQ+FGK V N+ +
Sbjct: 1320 GIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGK-----VAMRDNNQINRNNNF 1374
Query: 926 HDFFHSFLIVFRVLCGE-WIETMWDCME----------------VAGQTMCLTVFMMVMV 968
F + L++FR GE W E M C+ G + F+ +
Sbjct: 1375 QTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYM 1434
Query: 969 IGNLVVLNLFLALLLSSF 986
+ +++NLF+A+++ +F
Sbjct: 1435 LCAFLIINLFVAVIMDNF 1452
Score = 102 bits (255), Expect = 3e-21
Identities = 101/434 (23%), Positives = 180/434 (41%), Gaps = 62/434 (14%)
Query: 1101 LTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVE 1160
L + + + GE E E+ + D ++ +EK +G +D AE PE E
Sbjct: 398 LNLVLGVLSGEFSKER---EKAKARGDFQKLREKQQLEEDLKGY-LDWITQAEDIDPENE 453
Query: 1161 PE-----------ESLEPEACFTEDCVRKFK-------CCQISIEEGKGKLW--WNL--R 1198
E + E E+ TE+ + + CQ + + W WN R
Sbjct: 454 EEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNR 513
Query: 1199 KTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEML 1258
+ C V+ F ++ ++ L++ ++ E + Q + + + A+KV +F EML
Sbjct: 514 RRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQPDWLTQIQDIANKVLLALFTCEML 571
Query: 1259 LKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALS 1318
+K + G Q YF + + D +V + L I R +R LR +
Sbjct: 572 VKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTR 631
Query: 1319 RFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVS 1378
+ + +V +LL ++ SI ++LL+ +F +IFS++G+ LF GKF
Sbjct: 632 HWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--------------- 676
Query: 1379 VVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVE 1438
N+ E QT R FDN L++ Q+ T + W +MY + +
Sbjct: 677 ---NFDE-------TQTKR-----STFDNFPQALLTVFQILTGEDWNAVMYDGI----MA 717
Query: 1439 LQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYY 1498
+ + +YF+I I G++ LN+F+ + +DN + Q E+++K
Sbjct: 718 YGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKI 777
Query: 1499 NAMKKLGSKKPQKP 1512
+ L +KK KP
Sbjct: 778 ARKESLENKKNNKP 791
Score = 92.4 bits (228), Expect = 4e-18
Identities = 73/255 (28%), Positives = 123/255 (48%), Gaps = 20/255 (7%)
Query: 28 RIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPYYIN 87
+IA K + ++ED++ P P D+ G+ D PE+ + P P I+
Sbjct: 795 QIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEED-EPEVPAGPR----PRRIS 849
Query: 88 KKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMT 147
+ LN + I+ A +IL+ NPIR K++ H +F LI+ I+ + +
Sbjct: 850 E-----LNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 904
Query: 148 MSNP---PDWTKNV----EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVIT 200
+P + + +Y FT I+T E L+K+ G L F R+ +N LD V+
Sbjct: 905 AEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVG 964
Query: 201 FAYVTEFVDLGNVSA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 257
+ V+ + +S LR RVLR L+ I+ GLK +V + +++ + ++MI+T
Sbjct: 965 VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTL 1024
Query: 258 CLSVFALIGLQLFMG 272
+FA IG+QLF G
Sbjct: 1025 LQFMFACIGVQLFKG 1039
Score = 82.0 bits (201), Expect = 5e-15
Identities = 77/296 (26%), Positives = 133/296 (44%), Gaps = 61/296 (20%)
Query: 752 VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSV----LSVGNLVFTGIFTAEMF 807
+++V PF D+ I + I N + +A+ + P E S+ L F IFT E F
Sbjct: 120 ISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTVETF 177
Query: 808 LKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANV----EG------------LS 847
LKIIA + P Y + GWN+ D IV + L + L + EG +
Sbjct: 178 LKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVK 237
Query: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 906
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 238 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKM 297
Query: 907 YKECV--------------CKIS----------NDCELPRW--------HMHDFFHSFLI 934
+K C C S +C W + +F + L
Sbjct: 298 HKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECR-SGWVGPNGGITNFDNFAFAMLT 356
Query: 935 VFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSD 989
VF+ + E W + ++ + G + F+ +++ G+ VLNL L +L FS +
Sbjct: 357 VFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKE 412
Score = 78.6 bits (192), Expect = 6e-14
Identities = 80/394 (20%), Positives = 158/394 (40%), Gaps = 84/394 (21%)
Query: 1490 MTEEQKKYYNAMKKLGSKKPQKPIPRPA-----NKFQGMVFDFVTKQVFDISIMILICLN 1544
+++ +++ Y KK G+ +P N + V + FDI I++ I N
Sbjct: 80 LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139
Query: 1545 MVTMMVET---DDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY-----YFTIGWNI 1596
V + + +D S + L + F+++FT E LK+I+ Y GWN+
Sbjct: 140 CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199
Query: 1597 FDFVVVILSIVGMFLAELIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIRT 1648
DFV+VI+ + + L +L ++ + +R R+ R LRL+ G ++
Sbjct: 200 LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259
Query: 1649 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--------YVKREVGIDD------- 1693
+L +++ ++ L +I LL+ V+ IYAI G+ F + ++ ++
Sbjct: 260 VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319
Query: 1694 ------------------------MFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPP 1729
+ NF+ F +M+ +FQ T GW +L +
Sbjct: 320 SGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWM------ 373
Query: 1730 DCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEP 1789
D + +FVS +I V+N+ + V+ FS +E +
Sbjct: 374 --------------NDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS---KEREKA 416
Query: 1790 LSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFAD 1823
+ DF+ E ++ + D ++++ ++ D
Sbjct: 417 KARGDFQKLREK-QQLEEDLKGYLDWITQAEDID 449
Score = 57.4 bits (137), Expect = 1e-07
Identities = 40/172 (23%), Positives = 82/172 (47%), Gaps = 19/172 (11%)
Query: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYT 167
P NP + ++ S F ++ I+ N + + M + D + FTG++T
Sbjct: 1190 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1249
Query: 168 FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVDLGNVSALRT 218
E ++K++A + + D WN D ++ + + +E + +++ R
Sbjct: 1250 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRL 1305
Query: 219 FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
FRV+R +K +S G++T++ I+S + L V +L ++A+IG+Q+F
Sbjct: 1306 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF 1357
Score = 49.7 bits (117), Expect = 3e-05
Identities = 36/154 (23%), Positives = 69/154 (44%), Gaps = 16/154 (10%)
Query: 131 FNMLIMCTILTNCVFMTMS--NPPDWTKNVE----YTFTGIYTFESLIKILARGFCLEDF 184
F L++ + N + ++ N PDW ++ ++T E L+K+ + G
Sbjct: 525 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ---- 580
Query: 185 TFLRDPWNWLDFTVI------TFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIV 238
+ +N D V+ T E + +S R R+LR K L +V
Sbjct: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 640
Query: 239 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
+L+ S+K ++ +++L + +F+L+G+QLF G
Sbjct: 641 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 674
Score = 47.4 bits (111), Expect = 1e-04
Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 9/117 (7%)
Query: 365 TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRA------AGKTYMIFFVLVIFLGSFYLIN 418
++FD F A L++F+++T + W + + A +G I+F+++ G++ L+N
Sbjct: 686 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLN 745
Query: 419 LILAVVA---MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
+ LA+ E N A EEAE+KE + E L+ ++ A+++++
Sbjct: 746 VFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNK 802
Score = 37.0 bits (84), Expect = 0.19
Identities = 22/99 (22%), Positives = 47/99 (47%), Gaps = 10/99 (10%)
Query: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY----------MIFFVLVIFLGSFY 415
+FD A ++LF + T + W L + + G+ IFF++ I + +F+
Sbjct: 1083 NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFF 1142
Query: 416 LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLK 454
++N+ + V + ++EQ + + E + + Q + LK
Sbjct: 1143 MMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1181
>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform b [Homo sapiens]
Length = 2161
Score = 420 bits (1080), Expect = e-117
Identities = 336/1164 (28%), Positives = 559/1164 (48%), Gaps = 196/1164 (16%)
Query: 765 ITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWN 824
+ + + LNTL ++ EHY + + + + N V +FT EM +K+ ++ YF +N
Sbjct: 529 VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588
Query: 825 IFDGFIVSLSLMELGLANVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 879
FD F+V + E L +E G+SV R RLLR+FK+ + W +L+ L+ + NS+
Sbjct: 589 RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 648
Query: 880 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVL 939
++ +L L+L + + IF+++GMQLFG + ++ + R +F + L VF++L
Sbjct: 649 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 702
Query: 940 CGE-WIETMWDCM------EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLA 992
GE W M+D + +G +C+ F+++ + GN ++LN+FLA+ + DNLA
Sbjct: 703 TGEDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAV-----DNLA 756
Query: 993 ATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSC 1052
D +N Q K + E +K RK E L NKK++
Sbjct: 757 ---DAESLNTAQ-------------KEEAEEKERKKIARK----------ESLENKKNN- 789
Query: 1053 ISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGES 1112
+ I +S K +D+ +P VP VGE
Sbjct: 790 -------------------KPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVP--VGE- 827
Query: 1113 DFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFT 1172
EE +E+ E EPE P
Sbjct: 828 ----------------EEEEEE-----------------------EDEPEVPAGPRPRRI 848
Query: 1173 EDCVRKFKCCQISIEEGKGKLWWNLRKT------CYKIVEHNWFETFIVFMILLSSGALA 1226
+ K K I +G ++ L KT C+K++ H+ F I+ I+LSS ALA
Sbjct: 849 SELNMKEKIAPIP----EGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 904
Query: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF----QVYFTNAWCWLDFLIV 1282
ED I T+L Y D FT IF +E+LLK +G + N + LD L+V
Sbjct: 905 AED-PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 963
Query: 1283 DVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLL 1342
VSLVS + S + +K LR LR LRPLRA++R +G++ VV + AI +I N+++
Sbjct: 964 GVSLVSF---GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020
Query: 1343 VCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL--------IESNQ 1394
V + +F+ +GV LF GKFY C + +N EC+ L ++S
Sbjct: 1021 VTTLLQFMFACIGVQLFKGKFYRCTD---------EAKSNPEECRGLFILYKDGDVDSPV 1071
Query: 1395 TAR--WKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLY 1452
W+N NFDNV ++L V+TF+GW ++Y A+DS + P Y + + ++
Sbjct: 1072 VRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIF 1131
Query: 1453 FVIFIIFGSFFTLNLFIGVIIDNFNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511
F+I+II +FF +N+F+G +I F +Q +K++ ++ + Q Y A+K +
Sbjct: 1132 FIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------AR 1183
Query: 1512 PIPR--PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
P+ R P N +Q + V F+ + +LI LN + + ++ +QS+ + + +N+V
Sbjct: 1184 PLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMV 1243
Query: 1570 FIVLFTGECVLKLISLR-YYYFTIGWNIFDFVVVILSIVGMFLAEL-------------- 1614
F +FT E VLK+I+ + YF+ WN FD ++VI SI+ + L+E
Sbjct: 1244 FTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTAT 1303
Query: 1615 ----IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1670
E +S T F RL R+ R+++L+ +GIRTLL+ + S AL + LL+ ++
Sbjct: 1304 PGNSEESNRISITFF---RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1360
Query: 1671 MFIYAIFGMSNFAYV--KREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
FIYA+ GM F V + I+ NF+TF +++ LF+ T W ++ L
Sbjct: 1361 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPG-- 1418
Query: 1729 PDCDPDKDH-PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESA 1787
CDP+ D+ PG CG+ + I +F+S+ ++ +++N+++AVI++NF T + +
Sbjct: 1419 KLCDPESDYNPGEEY--TCGS-NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1475
Query: 1788 EPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAM 1842
L + F +W ++DP+A I+ + + PPL K P++V +L+AM
Sbjct: 1476 -ILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAM 1534
Query: 1843 DLPMVSGDRIHCLDILFAFTKRVL 1866
++P+ S + LFA + L
Sbjct: 1535 NMPLNSDGTVMFNATLFALVRTAL 1558
Score = 147 bits (372), Expect = 8e-35
Identities = 107/376 (28%), Positives = 180/376 (47%), Gaps = 73/376 (19%)
Query: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-PDWTKN--------V 158
AL+ L+ NPIR+ I I+ F++ I+ I NCV + + P P+ N V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164
Query: 159 EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAY-------VTEFVDLG 211
EY F I+T E+ +KI+A G L ++R+ WN LDF ++ +T+ + G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224
Query: 212 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 261
N V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Query: 262 FALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIE 321
+A+IGL+LF+G + C FF +S
Sbjct: 285 YAIIGLELFIGKMHKTC----------------FFADS---------------------- 306
Query: 322 DKSHFYFLEGQNDALLCGNSSDAGQC-PEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRL 380
+ + D C S + QC G C PN G T+FD F++A L++F+
Sbjct: 307 ------DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
Query: 381 MTQDFWEN-LYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAY-EEQNQATLEE 438
+T + W + LY + + ++FV ++ GSF+++NL+L V++ + +E+ +A
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 439 AEQKEAEFQQMLEQLK 454
QK E QQ+ E LK
Sbjct: 421 DFQKLREKQQLEEDLK 436
Score = 137 bits (346), Expect = 8e-32
Identities = 98/328 (29%), Positives = 157/328 (47%), Gaps = 41/328 (12%)
Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI----EQRKTIKTMLEYADKVFTYI 1252
+R+ C IVE F+ FI+ I + ALA IYI + + LE + F I
Sbjct: 115 IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 1253 FILEMLLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGA------- 1301
F +E LK +AYG Y N W LDF+IV V L S+ L G
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 1302 ----IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1357
+K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 1358 LFAGKFYHCINYTTGEMF------DVSVVNNYSECKALIESNQTARWKNVK---VNFDNV 1408
LF GK + + ++ + N +C A + + W NFDN
Sbjct: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTA-NGTECRSGWVGPNGGITNFDNF 350
Query: 1409 GLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLF 1468
L++ Q T +GW D++Y D+ EL ++YFV +IFGSFF LNL
Sbjct: 351 AFAMLTVFQCITMEGWTDVLYWMNDAMGFELP---------WVYFVSLVIFGSFFVLNLV 401
Query: 1469 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
+GV+ F+++++K + F +K+
Sbjct: 402 LGVLSGEFSKEREKAKARGDFQKLREKQ 429
Score = 120 bits (302), Expect = 1e-26
Identities = 78/273 (28%), Positives = 133/273 (48%), Gaps = 46/273 (16%)
Query: 754 LVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAM 813
+V PF + + + I+LNTL +AM+HY ++ F+ + + N+VFTG+FT EM LK+IA
Sbjct: 1201 VVNSSPF-EYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1259
Query: 814 DPYYYFQEGWNIFDGFIVSLSLMELGLANVE-----------------------GLSVLR 850
P YF + WN FD IV S++++ L+ + ++ R
Sbjct: 1260 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFR 1319
Query: 851 SFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC 910
FR++R+ KL + L+ S AL + L++A++ FI+AV+GMQ+FGK
Sbjct: 1320 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGK----- 1374
Query: 911 VCKISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCME----------------V 953
V N+ + F + L++FR GE W E M C+
Sbjct: 1375 VAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYT 1434
Query: 954 AGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
G + F+ ++ +++NLF+A+++ +F
Sbjct: 1435 CGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1467
Score = 102 bits (255), Expect = 3e-21
Identities = 101/434 (23%), Positives = 180/434 (41%), Gaps = 62/434 (14%)
Query: 1101 LTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVE 1160
L + + + GE E E+ + D ++ +EK +G +D AE PE E
Sbjct: 398 LNLVLGVLSGEFSKER---EKAKARGDFQKLREKQQLEEDLKGY-LDWITQAEDIDPENE 453
Query: 1161 PE-----------ESLEPEACFTEDCVRKFK-------CCQISIEEGKGKLW--WNL--R 1198
E + E E+ TE+ + + CQ + + W WN R
Sbjct: 454 EEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNR 513
Query: 1199 KTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEML 1258
+ C V+ F ++ ++ L++ ++ E + Q + + + A+KV +F EML
Sbjct: 514 RRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQPDWLTQIQDIANKVLLALFTCEML 571
Query: 1259 LKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALS 1318
+K + G Q YF + + D +V + L I R +R LR +
Sbjct: 572 VKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTR 631
Query: 1319 RFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVS 1378
+ + +V +LL ++ SI ++LL+ +F +IFS++G+ LF GKF
Sbjct: 632 HWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--------------- 676
Query: 1379 VVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVE 1438
N+ E QT R FDN L++ Q+ T + W +MY + +
Sbjct: 677 ---NFDE-------TQTKR-----STFDNFPQALLTVFQILTGEDWNAVMYDGI----MA 717
Query: 1439 LQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYY 1498
+ + +YF+I I G++ LN+F+ + +DN + Q E+++K
Sbjct: 718 YGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKI 777
Query: 1499 NAMKKLGSKKPQKP 1512
+ L +KK KP
Sbjct: 778 ARKESLENKKNNKP 791
Score = 92.4 bits (228), Expect = 4e-18
Identities = 73/255 (28%), Positives = 123/255 (48%), Gaps = 20/255 (7%)
Query: 28 RIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPYYIN 87
+IA K + ++ED++ P P D+ G+ D PE+ + P P I+
Sbjct: 795 QIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEED-EPEVPAGPR----PRRIS 849
Query: 88 KKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMT 147
+ LN + I+ A +IL+ NPIR K++ H +F LI+ I+ + +
Sbjct: 850 E-----LNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 904
Query: 148 MSNP---PDWTKNV----EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVIT 200
+P + + +Y FT I+T E L+K+ G L F R+ +N LD V+
Sbjct: 905 AEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVG 964
Query: 201 FAYVTEFVDLGNVSA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 257
+ V+ + +S LR RVLR L+ I+ GLK +V + +++ + ++MI+T
Sbjct: 965 VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTL 1024
Query: 258 CLSVFALIGLQLFMG 272
+FA IG+QLF G
Sbjct: 1025 LQFMFACIGVQLFKG 1039
Score = 82.0 bits (201), Expect = 5e-15
Identities = 77/296 (26%), Positives = 133/296 (44%), Gaps = 61/296 (20%)
Query: 752 VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSV----LSVGNLVFTGIFTAEMF 807
+++V PF D+ I + I N + +A+ + P E S+ L F IFT E F
Sbjct: 120 ISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTVETF 177
Query: 808 LKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANV----EG------------LS 847
LKIIA + P Y + GWN+ D IV + L + L + EG +
Sbjct: 178 LKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVK 237
Query: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 906
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 238 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKM 297
Query: 907 YKECV--------------CKIS----------NDCELPRW--------HMHDFFHSFLI 934
+K C C S +C W + +F + L
Sbjct: 298 HKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECR-SGWVGPNGGITNFDNFAFAMLT 356
Query: 935 VFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSD 989
VF+ + E W + ++ + G + F+ +++ G+ VLNL L +L FS +
Sbjct: 357 VFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKE 412
Score = 78.6 bits (192), Expect = 6e-14
Identities = 80/394 (20%), Positives = 158/394 (40%), Gaps = 84/394 (21%)
Query: 1490 MTEEQKKYYNAMKKLGSKKPQKPIPRPA-----NKFQGMVFDFVTKQVFDISIMILICLN 1544
+++ +++ Y KK G+ +P N + V + FDI I++ I N
Sbjct: 80 LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139
Query: 1545 MVTMMVET---DDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY-----YFTIGWNI 1596
V + + +D S + L + F+++FT E LK+I+ Y GWN+
Sbjct: 140 CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199
Query: 1597 FDFVVVILSIVGMFLAELIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIRT 1648
DFV+VI+ + + L +L ++ + +R R+ R LRL+ G ++
Sbjct: 200 LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259
Query: 1649 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--------YVKREVGIDD------- 1693
+L +++ ++ L +I LL+ V+ IYAI G+ F + ++ ++
Sbjct: 260 VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319
Query: 1694 ------------------------MFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPP 1729
+ NF+ F +M+ +FQ T GW +L +
Sbjct: 320 SGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWM------ 373
Query: 1730 DCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEP 1789
D + +FVS +I V+N+ + V+ FS +E +
Sbjct: 374 --------------NDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS---KEREKA 416
Query: 1790 LSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFAD 1823
+ DF+ E ++ + D ++++ ++ D
Sbjct: 417 KARGDFQKLREK-QQLEEDLKGYLDWITQAEDID 449
Score = 52.0 bits (123), Expect = 6e-06
Identities = 43/187 (22%), Positives = 84/187 (44%), Gaps = 34/187 (18%)
Query: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYT 167
P NP + ++ S F ++ I+ N + + M + D + FTG++T
Sbjct: 1190 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1249
Query: 168 FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVDL-------G 211
E ++K++A + + D WN D ++ + + TE ++ G
Sbjct: 1250 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG 1305
Query: 212 N--------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 263
N ++ R FRV+R +K +S G++T++ I+S + L V +L ++A
Sbjct: 1306 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYA 1365
Query: 264 LIGLQLF 270
+IG+Q+F
Sbjct: 1366 VIGMQMF 1372
Score = 49.7 bits (117), Expect = 3e-05
Identities = 36/154 (23%), Positives = 69/154 (44%), Gaps = 16/154 (10%)
Query: 131 FNMLIMCTILTNCVFMTMS--NPPDWTKNVE----YTFTGIYTFESLIKILARGFCLEDF 184
F L++ + N + ++ N PDW ++ ++T E L+K+ + G
Sbjct: 525 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ---- 580
Query: 185 TFLRDPWNWLDFTVI------TFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIV 238
+ +N D V+ T E + +S R R+LR K L +V
Sbjct: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 640
Query: 239 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
+L+ S+K ++ +++L + +F+L+G+QLF G
Sbjct: 641 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 674
Score = 47.4 bits (111), Expect = 1e-04
Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 9/117 (7%)
Query: 365 TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRA------AGKTYMIFFVLVIFLGSFYLIN 418
++FD F A L++F+++T + W + + A +G I+F+++ G++ L+N
Sbjct: 686 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLN 745
Query: 419 LILAVVA---MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
+ LA+ E N A EEAE+KE + E L+ ++ A+++++
Sbjct: 746 VFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNK 802
Score = 37.0 bits (84), Expect = 0.19
Identities = 22/99 (22%), Positives = 47/99 (47%), Gaps = 10/99 (10%)
Query: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY----------MIFFVLVIFLGSFY 415
+FD A ++LF + T + W L + + G+ IFF++ I + +F+
Sbjct: 1083 NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFF 1142
Query: 416 LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLK 454
++N+ + V + ++EQ + + E + + Q + LK
Sbjct: 1143 MMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1181
>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform a [Homo sapiens]
Length = 2181
Score = 420 bits (1080), Expect = e-117
Identities = 336/1164 (28%), Positives = 559/1164 (48%), Gaps = 196/1164 (16%)
Query: 765 ITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWN 824
+ + + LNTL ++ EHY + + + + N V +FT EM +K+ ++ YF +N
Sbjct: 549 VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 608
Query: 825 IFDGFIVSLSLMELGLANVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 879
FD F+V + E L +E G+SV R RLLR+FK+ + W +L+ L+ + NS+
Sbjct: 609 RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 668
Query: 880 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVL 939
++ +L L+L + + IF+++GMQLFG + ++ + R +F + L VF++L
Sbjct: 669 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 722
Query: 940 CGE-WIETMWDCM------EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLA 992
GE W M+D + +G +C+ F+++ + GN ++LN+FLA+ + DNLA
Sbjct: 723 TGEDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAV-----DNLA 776
Query: 993 ATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSC 1052
D +N Q K + E +K RK E L NKK++
Sbjct: 777 ---DAESLNTAQ-------------KEEAEEKERKKIARK----------ESLENKKNN- 809
Query: 1053 ISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGES 1112
+ I +S K +D+ +P VP VGE
Sbjct: 810 -------------------KPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVP--VGE- 847
Query: 1113 DFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFT 1172
EE +E+ E EPE P
Sbjct: 848 ----------------EEEEEE-----------------------EDEPEVPAGPRPRRI 868
Query: 1173 EDCVRKFKCCQISIEEGKGKLWWNLRKT------CYKIVEHNWFETFIVFMILLSSGALA 1226
+ K K I +G ++ L KT C+K++ H+ F I+ I+LSS ALA
Sbjct: 869 SELNMKEKIAPIP----EGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 924
Query: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF----QVYFTNAWCWLDFLIV 1282
ED I T+L Y D FT IF +E+LLK +G + N + LD L+V
Sbjct: 925 AED-PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 983
Query: 1283 DVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLL 1342
VSLVS + S + +K LR LR LRPLRA++R +G++ VV + AI +I N+++
Sbjct: 984 GVSLVSF---GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1040
Query: 1343 VCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL--------IESNQ 1394
V + +F+ +GV LF GKFY C + +N EC+ L ++S
Sbjct: 1041 VTTLLQFMFACIGVQLFKGKFYRCTD---------EAKSNPEECRGLFILYKDGDVDSPV 1091
Query: 1395 TAR--WKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLY 1452
W+N NFDNV ++L V+TF+GW ++Y A+DS + P Y + + ++
Sbjct: 1092 VRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIF 1151
Query: 1453 FVIFIIFGSFFTLNLFIGVIIDNFNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511
F+I+II +FF +N+F+G +I F +Q +K++ ++ + Q Y A+K +
Sbjct: 1152 FIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------AR 1203
Query: 1512 PIPR--PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
P+ R P N +Q + V F+ + +LI LN + + ++ +QS+ + + +N+V
Sbjct: 1204 PLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMV 1263
Query: 1570 FIVLFTGECVLKLISLR-YYYFTIGWNIFDFVVVILSIVGMFLAEL-------------- 1614
F +FT E VLK+I+ + YF+ WN FD ++VI SI+ + L+E
Sbjct: 1264 FTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTAT 1323
Query: 1615 ----IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1670
E +S T F RL R+ R+++L+ +GIRTLL+ + S AL + LL+ ++
Sbjct: 1324 PGNSEESNRISITFF---RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1380
Query: 1671 MFIYAIFGMSNFAYV--KREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
FIYA+ GM F V + I+ NF+TF +++ LF+ T W ++ L
Sbjct: 1381 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPG-- 1438
Query: 1729 PDCDPDKDH-PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESA 1787
CDP+ D+ PG CG+ + I +F+S+ ++ +++N+++AVI++NF T + +
Sbjct: 1439 KLCDPESDYNPGEEY--TCGS-NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1495
Query: 1788 EPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAM 1842
L + F +W ++DP+A I+ + + PPL K P++V +L+AM
Sbjct: 1496 -ILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAM 1554
Query: 1843 DLPMVSGDRIHCLDILFAFTKRVL 1866
++P+ S + LFA + L
Sbjct: 1555 NMPLNSDGTVMFNATLFALVRTAL 1578
Score = 149 bits (377), Expect = 2e-35
Identities = 109/376 (28%), Positives = 181/376 (48%), Gaps = 73/376 (19%)
Query: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-PDWTKN--------V 158
AL+ L+ NPIR+ I I+ F++ I+ I NCV + + P P+ N V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164
Query: 159 EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAY-------VTEFVDLG 211
EY F I+T E+ +KI+A G L ++R+ WN LDF ++ +T+ + G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224
Query: 212 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 261
N V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Query: 262 FALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIE 321
+A+IGL+LF+G + C FF +S
Sbjct: 285 YAIIGLELFIGKMHKTC----------------FFADS---------------------- 306
Query: 322 DKSHFYFLEGQNDALLCGNSSDAGQC-PEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRL 380
+ + D C S + QC G C PN G T+FD F++A L++F+
Sbjct: 307 ------DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360
Query: 381 MTQDFWENLYQLTLRAAGKTY-MIFFVLVIFLGSFYLINLILAVVAMAY-EEQNQATLEE 438
+T + W ++ A G + ++FV +I LGSF+++NL+L V++ + +E+ +A
Sbjct: 361 ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 439 AEQKEAEFQQMLEQLK 454
QK E QQ+ E LK
Sbjct: 421 DFQKLREKQQLEEDLK 436
Score = 133 bits (335), Expect = 2e-30
Identities = 97/328 (29%), Positives = 156/328 (47%), Gaps = 41/328 (12%)
Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI----EQRKTIKTMLEYADKVFTYI 1252
+R+ C IVE F+ FI+ I + ALA IYI + + LE + F I
Sbjct: 115 IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 1253 FILEMLLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGA------- 1301
F +E LK +AYG Y N W LDF+IV V L S+ L G
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 1302 ----IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1357
+K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 1358 LFAGKFYHCINYTTGEMF------DVSVVNNYSECKALIESNQTARWKNVK---VNFDNV 1408
LF GK + + ++ + N +C A + + W NFDN
Sbjct: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTA-NGTECRSGWVGPNGGITNFDNF 350
Query: 1409 GLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLF 1468
L++ Q T +GW D++Y D+ E + ++YFV II GSFF LNL
Sbjct: 351 AFAMLTVFQCITMEGWTDVLYWVNDAIGWE---------WPWVYFVSLIILGSFFVLNLV 401
Query: 1469 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
+GV+ F+++++K + F +K+
Sbjct: 402 LGVLSGEFSKEREKAKARGDFQKLREKQ 429
Score = 120 bits (302), Expect = 1e-26
Identities = 78/273 (28%), Positives = 133/273 (48%), Gaps = 46/273 (16%)
Query: 754 LVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAM 813
+V PF + + + I+LNTL +AM+HY ++ F+ + + N+VFTG+FT EM LK+IA
Sbjct: 1221 VVNSSPF-EYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1279
Query: 814 DPYYYFQEGWNIFDGFIVSLSLMELGLANVE-----------------------GLSVLR 850
P YF + WN FD IV S++++ L+ + ++ R
Sbjct: 1280 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFR 1339
Query: 851 SFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC 910
FR++R+ KL + L+ S AL + L++A++ FI+AV+GMQ+FGK
Sbjct: 1340 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGK----- 1394
Query: 911 VCKISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCME----------------V 953
V N+ + F + L++FR GE W E M C+
Sbjct: 1395 VAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYT 1454
Query: 954 AGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
G + F+ ++ +++NLF+A+++ +F
Sbjct: 1455 CGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1487
Score = 100 bits (249), Expect = 1e-20
Identities = 78/320 (24%), Positives = 140/320 (43%), Gaps = 38/320 (11%)
Query: 1195 WNL--RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYI 1252
WN R+ C V+ F ++ ++ L++ ++ E + Q + + + A+KV +
Sbjct: 528 WNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQPDWLTQIQDIANKVLLAL 585
Query: 1253 FILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312
F EML+K + G Q YF + + D +V + L I R +R LR
Sbjct: 586 FTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 645
Query: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTG 1372
+ + + +V +LL ++ SI ++LL+ +F +IFS++G+ LF GKF
Sbjct: 646 IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--------- 696
Query: 1373 EMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAV 1432
N+ E QT R FDN L++ Q+ T + W +MY +
Sbjct: 697 ---------NFDE-------TQTKR-----STFDNFPQALLTVFQILTGEDWNAVMYDGI 735
Query: 1433 DSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTE 1492
+ + + +YF+I I G++ LN+F+ + +DN + Q E
Sbjct: 736 ----MAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEE 791
Query: 1493 EQKKYYNAMKKLGSKKPQKP 1512
+++K + L +KK KP
Sbjct: 792 KERKKIARKESLENKKNNKP 811
Score = 92.4 bits (228), Expect = 4e-18
Identities = 73/255 (28%), Positives = 123/255 (48%), Gaps = 20/255 (7%)
Query: 28 RIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPYYIN 87
+IA K + ++ED++ P P D+ G+ D PE+ + P P I+
Sbjct: 815 QIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEED-EPEVPAGPR----PRRIS 869
Query: 88 KKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMT 147
+ LN + I+ A +IL+ NPIR K++ H +F LI+ I+ + +
Sbjct: 870 E-----LNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 924
Query: 148 MSNP---PDWTKNV----EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVIT 200
+P + + +Y FT I+T E L+K+ G L F R+ +N LD V+
Sbjct: 925 AEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVG 984
Query: 201 FAYVTEFVDLGNVSA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 257
+ V+ + +S LR RVLR L+ I+ GLK +V + +++ + ++MI+T
Sbjct: 985 VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTL 1044
Query: 258 CLSVFALIGLQLFMG 272
+FA IG+QLF G
Sbjct: 1045 LQFMFACIGVQLFKG 1059
Score = 82.0 bits (201), Expect = 5e-15
Identities = 77/296 (26%), Positives = 133/296 (44%), Gaps = 61/296 (20%)
Query: 752 VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSV----LSVGNLVFTGIFTAEMF 807
+++V PF D+ I + I N + +A+ + P E S+ L F IFT E F
Sbjct: 120 ISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTVETF 177
Query: 808 LKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANV----EG------------LS 847
LKIIA + P Y + GWN+ D IV + L + L + EG +
Sbjct: 178 LKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVK 237
Query: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 906
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 238 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKM 297
Query: 907 YKECV--------------CKIS----------NDCELPRW--------HMHDFFHSFLI 934
+K C C S +C W + +F + L
Sbjct: 298 HKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECR-SGWVGPNGGITNFDNFAFAMLT 356
Query: 935 VFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSD 989
VF+ + E W + ++ + G F+ ++++G+ VLNL L +L FS +
Sbjct: 357 VFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKE 412
Score = 79.7 bits (195), Expect = 3e-14
Identities = 82/398 (20%), Positives = 161/398 (40%), Gaps = 92/398 (23%)
Query: 1490 MTEEQKKYYNAMKKLGSKKPQKPIPRPA-----NKFQGMVFDFVTKQVFDISIMILICLN 1544
+++ +++ Y KK G+ +P N + V + FDI I++ I N
Sbjct: 80 LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139
Query: 1545 MVTMMVET---DDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY-----YFTIGWNI 1596
V + + +D S + L + F+++FT E LK+I+ Y GWN+
Sbjct: 140 CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199
Query: 1597 FDFVVVILSIVGMFLAELIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIRT 1648
DFV+VI+ + + L +L ++ + +R R+ R LRL+ G ++
Sbjct: 200 LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259
Query: 1649 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--------YVKREVGIDD------- 1693
+L +++ ++ L +I LL+ V+ IYAI G+ F + ++ ++
Sbjct: 260 VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319
Query: 1694 ------------------------MFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPP 1729
+ NF+ F +M+ +FQ T GW +L +
Sbjct: 320 SGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWV------ 373
Query: 1730 DCDPDKDHPGSSVKGDCGNPSVG----IFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1785
N ++G +FVS II+ V+N+ + V+ FS +E
Sbjct: 374 ------------------NDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFS---KE 412
Query: 1786 SAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFAD 1823
+ + DF+ E ++ + D ++++ ++ D
Sbjct: 413 REKAKARGDFQKLREK-QQLEEDLKGYLDWITQAEDID 449
Score = 52.0 bits (123), Expect = 6e-06
Identities = 43/187 (22%), Positives = 84/187 (44%), Gaps = 34/187 (18%)
Query: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYT 167
P NP + ++ S F ++ I+ N + + M + D + FTG++T
Sbjct: 1210 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1269
Query: 168 FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVDL-------G 211
E ++K++A + + D WN D ++ + + TE ++ G
Sbjct: 1270 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG 1325
Query: 212 N--------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 263
N ++ R FRV+R +K +S G++T++ I+S + L V +L ++A
Sbjct: 1326 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYA 1385
Query: 264 LIGLQLF 270
+IG+Q+F
Sbjct: 1386 VIGMQMF 1392
Score = 50.8 bits (120), Expect = 1e-05
Identities = 45/189 (23%), Positives = 84/189 (44%), Gaps = 20/189 (10%)
Query: 97 GKAISRFSATPALYILTPFNPIR-KLAIKILVHSLFNMLIMCTILTNCVFMTMS--NPPD 153
G+AIS+ + FN R + A+K + F L++ + N + ++ N PD
Sbjct: 513 GQAISKSKLSRRWRRWNRFNRRRCRAAVKSVT---FYWLVIVLVFLNTLTISSEHYNQPD 569
Query: 154 WTKNVE----YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVI------TFAY 203
W ++ ++T E L+K+ + G + +N D V+ T
Sbjct: 570 WLTQIQDIANKVLLALFTCEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILV 625
Query: 204 VTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 263
E + +S R R+LR K L +V +L+ S+K ++ +++L + +F+
Sbjct: 626 ELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFS 685
Query: 264 LIGLQLFMG 272
L+G+QLF G
Sbjct: 686 LLGMQLFGG 694
Score = 47.4 bits (111), Expect = 1e-04
Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 9/117 (7%)
Query: 365 TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRA------AGKTYMIFFVLVIFLGSFYLIN 418
++FD F A L++F+++T + W + + A +G I+F+++ G++ L+N
Sbjct: 706 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLN 765
Query: 419 LILAVVA---MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
+ LA+ E N A EEAE+KE + E L+ ++ A+++++
Sbjct: 766 VFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNK 822
Score = 37.0 bits (84), Expect = 0.19
Identities = 22/99 (22%), Positives = 47/99 (47%), Gaps = 10/99 (10%)
Query: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY----------MIFFVLVIFLGSFY 415
+FD A ++LF + T + W L + + G+ IFF++ I + +F+
Sbjct: 1103 NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFF 1162
Query: 416 LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLK 454
++N+ + V + ++EQ + + E + + Q + LK
Sbjct: 1163 MMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1201
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 338 bits (866), Expect = 4e-92
Identities = 208/625 (33%), Positives = 342/625 (54%), Gaps = 39/625 (6%)
Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
R C I+ H F+ ++ I L+ +A E IE T + L ++ +FT IF+ EM
Sbjct: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184
Query: 1258 LLKWVA----YGFQVYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1310
LK V+ +G Q Y ++W LD +V VS++ + A+A G LG ++ LR LR
Sbjct: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244
Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GV LF GKFYHC+
Sbjct: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1302
Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
D + N S+C A RW + K NFDN+G +SL +A+ GW++IMY
Sbjct: 1303 ----VDTRNITNRSDCMA-----ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1353
Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
+D+ V+ QP N +M LYF+ F++ SFF LN+F+GV+++NF++ ++ ++
Sbjct: 1354 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1413
Query: 1491 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV 1550
EE K ++K K + P + ++ T DI I +ICLN+VTM +
Sbjct: 1414 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1471
Query: 1551 ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGM 1609
E +Q + L + N +F +F E VLKL++ +F WN D +V+LS++G+
Sbjct: 1472 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1531
Query: 1610 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1667
L E+ ++PT+ R++R+ RI R+L+L+K A G+R LL ++ +LP + N+GLL
Sbjct: 1532 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1591
Query: 1668 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1722
L+ FIYA G+ F + G+ FE FG + + LFQ++T W+G++
Sbjct: 1592 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1651
Query: 1723 ILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1782
L DC D+ SS++ V +FVS+++ + V++N+ +AV++++ +
Sbjct: 1652 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701
Query: 1783 TEESAEPLSEDDFEMFYEVWEKFDP 1807
+E+ E +E D E+ E+ P
Sbjct: 1702 NKEAQED-AEMDAELELEMAHGLGP 1725
Score = 143 bits (360), Expect = 2e-33
Identities = 85/287 (29%), Positives = 154/287 (53%), Gaps = 18/287 (6%)
Query: 738 IWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
+W C W + + + +V + + I + I++NT+ M +EH+ E+ +++L + N+V
Sbjct: 584 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643
Query: 798 FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRV 857
FT +F EM LK+ A + Y + +NIFD IV +S+ E+ GLSVLR+FRLLRV
Sbjct: 644 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 703
Query: 858 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIS-- 915
KL + P L + ++ ++ + ++L + +FIF+++GM +FG CK S
Sbjct: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFG-------CKFSLR 756
Query: 916 ---NDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971
D R + + + VF++L E W +++ M L F+ +M GN
Sbjct: 757 TDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL-YFVALMTFGN 815
Query: 972 LVVLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 1015
V+ NL +A+L+ F ++ N + +D+D +N++ ++Q+G+D
Sbjct: 816 YVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 861
Score = 130 bits (328), Expect = 1e-29
Identities = 110/392 (28%), Positives = 181/392 (46%), Gaps = 42/392 (10%)
Query: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-------PDWTKNVEY 160
A + L R IK++ + F + M IL NCV + M P D K ++
Sbjct: 58 AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117
Query: 161 TFTGIYTF---ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNV--SA 215
I+ F E ++K++A G + +L D WN LDF ++ V +DL N+ SA
Sbjct: 118 FDDFIFIFFAMEMVLKMVALGIFGKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176
Query: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275
+RT RVLR LK I+ +P ++ +V L+ ++ L +V++L F +F +IG+QL+ G LR
Sbjct: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
Query: 276 NKC-----------LQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWD--EYIED 322
N+C + PP E + F + NG + E
Sbjct: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296
Query: 323 KSHFY-FLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLM 381
K Y F G+ D G + + +C NP+ G +FD +A++ +F+++
Sbjct: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYN--VCRTGSANPHKGAINFDNIGYAWIVIFQVI 354
Query: 382 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQ 441
T + W + + A I+F+L+I +GSF++INL L V+A + +E
Sbjct: 355 TLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SET 404
Query: 442 KEAEFQQMLEQLKKQQEEAQAAAAAASAESRD 473
K+ E + MLEQ +Q ++ A+ AE D
Sbjct: 405 KQREHRLMLEQ---RQRYLSSSTVASYAEPGD 433
Score = 112 bits (280), Expect = 4e-24
Identities = 84/307 (27%), Positives = 145/307 (47%), Gaps = 42/307 (13%)
Query: 715 MEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTL 774
+ LE+ R+K Y +A C + L++ + ++D+ IT I LN +
Sbjct: 1419 LRRLEKKRRKAQRLPY-YATYC----------HTRLLIHSMCTSHYLDIFITFIICLNVV 1467
Query: 775 FMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLS 834
M++EHY + L N +FT +F E LK++A +F++ WN D IV LS
Sbjct: 1468 TMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLS 1527
Query: 835 LMELGLANVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 884
+M + L +E + ++R R+ RV KL K + L+ + ++ +GNL
Sbjct: 1528 VMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNL 1587
Query: 885 TLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE 942
L+ ++ FI+A +G++LFGK VC N CE H +F +FL +F+V G+
Sbjct: 1588 GLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1643
Query: 943 -W----IETMWDCMEVAGQTMCLT--------VFMMVMVIGNLVVLNLFLALLLSSFSSD 989
W +T+ DC + CL+ F+ ++ V++N+ +A+L+
Sbjct: 1644 NWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701
Query: 990 NLAATDD 996
N A +D
Sbjct: 1702 NKEAQED 1708
Score = 102 bits (255), Expect = 3e-21
Identities = 74/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)
Query: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI--NLVFIVL 1573
P N+F+ + + ++FD ++ I LN +T+ +E T ++ N +F +
Sbjct: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1179
Query: 1574 FTGECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628
F GE LK++SL Y Y WN+ D +V +SI+ + ++ + RV+
Sbjct: 1180 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1239
Query: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKR 1687
RL R R LR+I A G++ ++ L+ SL + NI L+ I+ I G+ F
Sbjct: 1240 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1299
Query: 1688 EVGID-------------------DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
+G+D +NF+ G +++ LF + + GW ++ L++
Sbjct: 1300 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359
Query: 1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779
D P +H NP + + +F+S+++I V+NM++ V++ENF
Sbjct: 1360 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1399
Score = 97.1 bits (240), Expect = 2e-19
Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 63/401 (15%)
Query: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182
S++S E S +A E + +G E+ EE E +A + V + C
Sbjct: 534 STDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQA---DGAV--WLC- 587
Query: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242
G +W R IV+ +F I+ IL+++ ++ E + EQ + + +L
Sbjct: 588 --------GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNIL 637
Query: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302
E + VFT +F LEM+LK A+G Y N + D +IV +S+ + A G +
Sbjct: 638 EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGL 692
Query: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362
LRT R LR L+ + +R + L+ + ++ ++ ++F IFSI+G+++F K
Sbjct: 693 SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 752
Query: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFK 1422
F + TG+ + NFD++ +++ Q+ T +
Sbjct: 753 F--SLRTDTGDTVP------------------------DRKNFDSLLWAIVTVFQILTQE 786
Query: 1423 GWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ--- 1479
W ++Y + S + + LYFV + FG++ NL + ++++ F +
Sbjct: 787 DWNVVLYNGMASTSP----------WASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDA 836
Query: 1480 KKKFGGQDIFMT--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1518
+ + +D + EE K + G K PIP N
Sbjct: 837 NRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 876
Score = 97.1 bits (240), Expect = 2e-19
Identities = 75/281 (26%), Positives = 135/281 (48%), Gaps = 39/281 (13%)
Query: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTG 800
P + + L ++ D + I LN + +A+E P E S+ L+V N +FT
Sbjct: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTA 1178
Query: 801 IFTAEMFLKIIAMDPYY----YFQEGWNIFDGFIVSLSLMEL--GLANVEG------LSV 848
IF EM LK++++ Y+ Y + WN+ DGF+V +S++++ LA+ G L V
Sbjct: 1179 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1238
Query: 849 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908
LR R LR ++ P L ++++ + +S+ +GN+ L+ IF ++G+QLF +
Sbjct: 1239 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1298
Query: 909 ECV----CKISN--DCELP--RWHMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVA 954
C+ I+N DC RW H D L+ VL + W+ M++ ++
Sbjct: 1299 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1358
Query: 955 G---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
L F+ ++I + VLN+F+ +++ +F
Sbjct: 1359 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1399
Score = 95.9 bits (237), Expect = 4e-19
Identities = 72/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)
Query: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199
S S + P +G P V P L P A F C+R+ + R
Sbjct: 30 SPPSSPPGLEEPLDGADPHV-PHPDLAPIAFF---CLRQTT---------------SPRN 70
Query: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFILE 1256
C K+V + WFE + +ILL+ L + K + + D +F + F +E
Sbjct: 71 WCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FAME 129
Query: 1257 MLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
M+LK VA +G + Y + W LDF IV +V + + + + ++RT+R LRP
Sbjct: 130 MVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRP 185
Query: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
L+A++R MR++VN LL +P + NVLL+C + IF I+GV L+AG
Sbjct: 186 LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 95.9 bits (237), Expect = 4e-19
Identities = 81/313 (25%), Positives = 145/313 (46%), Gaps = 48/313 (15%)
Query: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY 1587
V + F+ IM+ I +N V+M +E +Q +E+TNIL N+VF +F E +LKL +
Sbjct: 602 VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 661
Query: 1588 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1646
+ Y +NIFD ++VI+SI E++ + + V+R R+ R+L+L++ +
Sbjct: 662 FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 713
Query: 1647 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG--IDDMFNFETFG 1701
R L LM ++ + +LL L +FI++I GM F ++ + G + D NF++
Sbjct: 714 RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 773
Query: 1702 NSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYII 1761
+++ +FQI T W+ +L + S P +FV+ +
Sbjct: 774 WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 812
Query: 1762 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDF 1821
V+ N+ +A+++E F + + ED ++ EF KL +
Sbjct: 813 FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQ-------------SSSNIEEFDKLQEG 859
Query: 1822 ADALDPPLLIAKP 1834
D+ P L P
Sbjct: 860 LDSSGDPKLCPIP 872
Score = 95.9 bits (237), Expect = 4e-19
Identities = 85/371 (22%), Positives = 156/371 (42%), Gaps = 71/371 (19%)
Query: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE-------- 159
++Y+ +P N R L I+ H LF+ +++ I NC+ + + P + E
Sbjct: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173
Query: 160 YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--------- 210
Y FT I+ E +K+++ G + +LR WN LD ++ + + V L
Sbjct: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233
Query: 211 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
G + LR R LR L+ IS PGLK +V LI S+K + +++++ +F ++G+QLF
Sbjct: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293
Query: 271 MGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLE 330
G + CL N N D + +N+D + + L
Sbjct: 1294 KGKFYH-CLGVDTRN----------ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLA 1342
Query: 331 GQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLY 390
+ +G++ N Y D + + + + W LY
Sbjct: 1343 SK----------------DGWV--------NIMYNGLDAVA---VDQQPVTNHNPWMLLY 1375
Query: 391 QLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 450
I F+L++ SF+++N+ + VV + + Q +EAE+ ++ L
Sbjct: 1376 -----------FISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRL 1419
Query: 451 EQLKKQQEEAQ 461
+L+K++ +AQ
Sbjct: 1420 RRLEKKRRKAQ 1430
Score = 70.5 bits (171), Expect = 2e-11
Identities = 50/169 (29%), Positives = 89/169 (52%), Gaps = 15/169 (8%)
Query: 131 FNMLIMCTILTNCVFMTMSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 184
FN IM IL N V M + + P + T +E FT ++ E ++K+ A G F
Sbjct: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662
Query: 185 TFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
+LR+P+N D ++I + E V G +S LRTFR+LR LK + +P L+ + L+
Sbjct: 663 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 721
Query: 243 QSVKKLSDVMILTVFCLSVFALIGLQLF--MGNLRNKCLQWPPDNSSFE 289
+++ ++ +L + + +F+++G+ +F +LR PD +F+
Sbjct: 722 KTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 770
Score = 69.7 bits (169), Expect = 3e-11
Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)
Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
+NFDN+G ++ + QV T +GW++IMY +D+ + Y ++YF++ II GSF
Sbjct: 338 INFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFYNFIYFILLIIVGSF 387
Query: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
F +NL + VI F++ K++ + M E++++Y ++
Sbjct: 388 FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
Score = 66.6 bits (161), Expect = 2e-10
Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)
Query: 755 VVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKI 810
+V +P+ + + I+LN + + M + +L V + F EM LK+
Sbjct: 75 MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
Query: 811 IAMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWP 865
+A+ + Y + WN D FIV ++E L L N+ LS +R+ R+LR K P
Sbjct: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193
Query: 866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKISNDCEL 920
++ +L+ ++ +++ LGN+ L+ + FIF ++G+QL+ + + E I D L
Sbjct: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253
Query: 921 PRWH 924
P ++
Sbjct: 254 PPYY 257
Score = 57.0 bits (136), Expect = 2e-07
Identities = 49/163 (30%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 1533 FDISIMILICLNMVT--MMVETDDQS--QEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
F+ M++I LN VT M DD + IL + + F E VLK+++L +
Sbjct: 81 FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
Y WN DF +V+ +V L + IR R+ R L+ I
Sbjct: 141 GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A + R
Sbjct: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
Score = 49.7 bits (117), Expect = 3e-05
Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 14/129 (10%)
Query: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 412
+ +F+ F AFL+LF++ T D W + + TLR + ++FV +
Sbjct: 1623 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1682
Query: 413 SFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
F LIN+++AV+ ++ N+ E+AE +AE + LE + + A R
Sbjct: 1683 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE--LEMAHGLGPGPRLPTGSPGAPGR 1739
Query: 473 DFSGAGGIG 481
GAGG G
Sbjct: 1740 GPGGAGGGG 1748
Score = 48.1 bits (113), Expect = 8e-05
Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)
Query: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
+FD+ WA +++F+++TQ+ W + + + ++FV ++ G++ L NL++A++
Sbjct: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
Query: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 458
++ + A +++ ++ +E+ K QE
Sbjct: 828 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 858
Score = 33.1 bits (74), Expect = 2.8
Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 930 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987
++++++F+V+ E W+E M+ M+ A F++++++G+ ++NL L ++ + FS
Sbjct: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 338 bits (866), Expect = 4e-92
Identities = 208/625 (33%), Positives = 342/625 (54%), Gaps = 39/625 (6%)
Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
R C I+ H F+ ++ I L+ +A E IE T + L ++ +FT IF+ EM
Sbjct: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219
Query: 1258 LLKWVA----YGFQVYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1310
LK V+ +G Q Y ++W LD +V VS++ + A+A G LG ++ LR LR
Sbjct: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279
Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GV LF GKFYHC+
Sbjct: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1337
Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
D + N S+C A RW + K NFDN+G +SL +A+ GW++IMY
Sbjct: 1338 ----VDTRNITNRSDCMA-----ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1388
Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
+D+ V+ QP N +M LYF+ F++ SFF LN+F+GV+++NF++ ++ ++
Sbjct: 1389 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1448
Query: 1491 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV 1550
EE K ++K K + P + ++ T DI I +ICLN+VTM +
Sbjct: 1449 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1506
Query: 1551 ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGM 1609
E +Q + L + N +F +F E VLKL++ +F WN D +V+LS++G+
Sbjct: 1507 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1566
Query: 1610 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1667
L E+ ++PT+ R++R+ RI R+L+L+K A G+R LL ++ +LP + N+GLL
Sbjct: 1567 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1626
Query: 1668 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1722
L+ FIYA G+ F + G+ FE FG + + LFQ++T W+G++
Sbjct: 1627 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1686
Query: 1723 ILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1782
L DC D+ SS++ V +FVS+++ + V++N+ +AV++++ +
Sbjct: 1687 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736
Query: 1783 TEESAEPLSEDDFEMFYEVWEKFDP 1807
+E+ E +E D E+ E+ P
Sbjct: 1737 NKEAQED-AEMDAELELEMAHGLGP 1760
Score = 143 bits (360), Expect = 2e-33
Identities = 85/287 (29%), Positives = 154/287 (53%), Gaps = 18/287 (6%)
Query: 738 IWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
+W C W + + + +V + + I + I++NT+ M +EH+ E+ +++L + N+V
Sbjct: 619 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 678
Query: 798 FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRV 857
FT +F EM LK+ A + Y + +NIFD IV +S+ E+ GLSVLR+FRLLRV
Sbjct: 679 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 738
Query: 858 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIS-- 915
KL + P L + ++ ++ + ++L + +FIF+++GM +FG CK S
Sbjct: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFG-------CKFSLR 791
Query: 916 ---NDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971
D R + + + VF++L E W +++ M L F+ +M GN
Sbjct: 792 TDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL-YFVALMTFGN 850
Query: 972 LVVLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 1015
V+ NL +A+L+ F ++ N + +D+D +N++ ++Q+G+D
Sbjct: 851 YVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 896
Score = 130 bits (328), Expect = 1e-29
Identities = 110/392 (28%), Positives = 181/392 (46%), Gaps = 42/392 (10%)
Query: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-------PDWTKNVEY 160
A + L R IK++ + F + M IL NCV + M P D K ++
Sbjct: 58 AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117
Query: 161 TFTGIYTF---ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNV--SA 215
I+ F E ++K++A G + +L D WN LDF ++ V +DL N+ SA
Sbjct: 118 FDDFIFIFFAMEMVLKMVALGIFGKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176
Query: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275
+RT RVLR LK I+ +P ++ +V L+ ++ L +V++L F +F +IG+QL+ G LR
Sbjct: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
Query: 276 NKC-----------LQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWD--EYIED 322
N+C + PP E + F + NG + E
Sbjct: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296
Query: 323 KSHFY-FLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLM 381
K Y F G+ D G + + +C NP+ G +FD +A++ +F+++
Sbjct: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYN--VCRTGSANPHKGAINFDNIGYAWIVIFQVI 354
Query: 382 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQ 441
T + W + + A I+F+L+I +GSF++INL L V+A + +E
Sbjct: 355 TLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SET 404
Query: 442 KEAEFQQMLEQLKKQQEEAQAAAAAASAESRD 473
K+ E + MLEQ +Q ++ A+ AE D
Sbjct: 405 KQREHRLMLEQ---RQRYLSSSTVASYAEPGD 433
Score = 112 bits (280), Expect = 4e-24
Identities = 84/307 (27%), Positives = 145/307 (47%), Gaps = 42/307 (13%)
Query: 715 MEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTL 774
+ LE+ R+K Y +A C + L++ + ++D+ IT I LN +
Sbjct: 1454 LRRLEKKRRKAQRLPY-YATYC----------HTRLLIHSMCTSHYLDIFITFIICLNVV 1502
Query: 775 FMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLS 834
M++EHY + L N +FT +F E LK++A +F++ WN D IV LS
Sbjct: 1503 TMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLS 1562
Query: 835 LMELGLANVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 884
+M + L +E + ++R R+ RV KL K + L+ + ++ +GNL
Sbjct: 1563 VMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNL 1622
Query: 885 TLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE 942
L+ ++ FI+A +G++LFGK VC N CE H +F +FL +F+V G+
Sbjct: 1623 GLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1678
Query: 943 -W----IETMWDCMEVAGQTMCLT--------VFMMVMVIGNLVVLNLFLALLLSSFSSD 989
W +T+ DC + CL+ F+ ++ V++N+ +A+L+
Sbjct: 1679 NWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736
Query: 990 NLAATDD 996
N A +D
Sbjct: 1737 NKEAQED 1743
Score = 102 bits (255), Expect = 3e-21
Identities = 74/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)
Query: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI--NLVFIVL 1573
P N+F+ + + ++FD ++ I LN +T+ +E T ++ N +F +
Sbjct: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1214
Query: 1574 FTGECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628
F GE LK++SL Y Y WN+ D +V +SI+ + ++ + RV+
Sbjct: 1215 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1274
Query: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKR 1687
RL R R LR+I A G++ ++ L+ SL + NI L+ I+ I G+ F
Sbjct: 1275 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1334
Query: 1688 EVGID-------------------DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
+G+D +NF+ G +++ LF + + GW ++ L++
Sbjct: 1335 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394
Query: 1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779
D P +H NP + + +F+S+++I V+NM++ V++ENF
Sbjct: 1395 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1434
Score = 97.1 bits (240), Expect = 2e-19
Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 63/401 (15%)
Query: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182
S++S E S +A E + +G E+ EE E +A + V + C
Sbjct: 569 STDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQA---DGAV--WLC- 622
Query: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242
G +W R IV+ +F I+ IL+++ ++ E + EQ + + +L
Sbjct: 623 --------GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNIL 672
Query: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302
E + VFT +F LEM+LK A+G Y N + D +IV +S+ + A G +
Sbjct: 673 EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGL 727
Query: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362
LRT R LR L+ + +R + L+ + ++ ++ ++F IFSI+G+++F K
Sbjct: 728 SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 787
Query: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFK 1422
F + TG+ + NFD++ +++ Q+ T +
Sbjct: 788 F--SLRTDTGDTVP------------------------DRKNFDSLLWAIVTVFQILTQE 821
Query: 1423 GWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ--- 1479
W ++Y + S + + LYFV + FG++ NL + ++++ F +
Sbjct: 822 DWNVVLYNGMASTSP----------WASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDA 871
Query: 1480 KKKFGGQDIFMT--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1518
+ + +D + EE K + G K PIP N
Sbjct: 872 NRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 911
Score = 97.1 bits (240), Expect = 2e-19
Identities = 75/281 (26%), Positives = 135/281 (48%), Gaps = 39/281 (13%)
Query: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTG 800
P + + L ++ D + I LN + +A+E P E S+ L+V N +FT
Sbjct: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTA 1213
Query: 801 IFTAEMFLKIIAMDPYY----YFQEGWNIFDGFIVSLSLMEL--GLANVEG------LSV 848
IF EM LK++++ Y+ Y + WN+ DGF+V +S++++ LA+ G L V
Sbjct: 1214 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1273
Query: 849 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908
LR R LR ++ P L ++++ + +S+ +GN+ L+ IF ++G+QLF +
Sbjct: 1274 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1333
Query: 909 ECV----CKISN--DCELP--RWHMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVA 954
C+ I+N DC RW H D L+ VL + W+ M++ ++
Sbjct: 1334 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1393
Query: 955 G---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
L F+ ++I + VLN+F+ +++ +F
Sbjct: 1394 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1434
Score = 95.9 bits (237), Expect = 4e-19
Identities = 72/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)
Query: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199
S S + P +G P V P L P A F C+R+ + R
Sbjct: 30 SPPSSPPGLEEPLDGADPHV-PHPDLAPIAFF---CLRQTT---------------SPRN 70
Query: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFILE 1256
C K+V + WFE + +ILL+ L + K + + D +F + F +E
Sbjct: 71 WCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FAME 129
Query: 1257 MLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
M+LK VA +G + Y + W LDF IV +V + + + + ++RT+R LRP
Sbjct: 130 MVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRP 185
Query: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
L+A++R MR++VN LL +P + NVLL+C + IF I+GV L+AG
Sbjct: 186 LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 95.9 bits (237), Expect = 4e-19
Identities = 81/313 (25%), Positives = 145/313 (46%), Gaps = 48/313 (15%)
Query: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY 1587
V + F+ IM+ I +N V+M +E +Q +E+TNIL N+VF +F E +LKL +
Sbjct: 637 VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 696
Query: 1588 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1646
+ Y +NIFD ++VI+SI E++ + + V+R R+ R+L+L++ +
Sbjct: 697 FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 748
Query: 1647 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG--IDDMFNFETFG 1701
R L LM ++ + +LL L +FI++I GM F ++ + G + D NF++
Sbjct: 749 RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 808
Query: 1702 NSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYII 1761
+++ +FQI T W+ +L + S P +FV+ +
Sbjct: 809 WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 847
Query: 1762 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDF 1821
V+ N+ +A+++E F + + ED ++ EF KL +
Sbjct: 848 FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQ-------------SSSNIEEFDKLQEG 894
Query: 1822 ADALDPPLLIAKP 1834
D+ P L P
Sbjct: 895 LDSSGDPKLCPIP 907
Score = 95.9 bits (237), Expect = 4e-19
Identities = 85/371 (22%), Positives = 156/371 (42%), Gaps = 71/371 (19%)
Query: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE-------- 159
++Y+ +P N R L I+ H LF+ +++ I NC+ + + P + E
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208
Query: 160 YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--------- 210
Y FT I+ E +K+++ G + +LR WN LD ++ + + V L
Sbjct: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268
Query: 211 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
G + LR R LR L+ IS PGLK +V LI S+K + +++++ +F ++G+QLF
Sbjct: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328
Query: 271 MGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLE 330
G + CL N N D + +N+D + + L
Sbjct: 1329 KGKFYH-CLGVDTRN----------ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLA 1377
Query: 331 GQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLY 390
+ +G++ N Y D + + + + W LY
Sbjct: 1378 SK----------------DGWV--------NIMYNGLDAVA---VDQQPVTNHNPWMLLY 1410
Query: 391 QLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 450
I F+L++ SF+++N+ + VV + + Q +EAE+ ++ L
Sbjct: 1411 -----------FISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRL 1454
Query: 451 EQLKKQQEEAQ 461
+L+K++ +AQ
Sbjct: 1455 RRLEKKRRKAQ 1465
Score = 70.5 bits (171), Expect = 2e-11
Identities = 50/169 (29%), Positives = 89/169 (52%), Gaps = 15/169 (8%)
Query: 131 FNMLIMCTILTNCVFMTMSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 184
FN IM IL N V M + + P + T +E FT ++ E ++K+ A G F
Sbjct: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 697
Query: 185 TFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
+LR+P+N D ++I + E V G +S LRTFR+LR LK + +P L+ + L+
Sbjct: 698 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 756
Query: 243 QSVKKLSDVMILTVFCLSVFALIGLQLF--MGNLRNKCLQWPPDNSSFE 289
+++ ++ +L + + +F+++G+ +F +LR PD +F+
Sbjct: 757 KTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 805
Score = 69.7 bits (169), Expect = 3e-11
Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)
Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
+NFDN+G ++ + QV T +GW++IMY +D+ + Y ++YF++ II GSF
Sbjct: 338 INFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFYNFIYFILLIIVGSF 387
Query: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
F +NL + VI F++ K++ + M E++++Y ++
Sbjct: 388 FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
Score = 66.6 bits (161), Expect = 2e-10
Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)
Query: 755 VVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKI 810
+V +P+ + + I+LN + + M + +L V + F EM LK+
Sbjct: 75 MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
Query: 811 IAMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWP 865
+A+ + Y + WN D FIV ++E L L N+ LS +R+ R+LR K P
Sbjct: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193
Query: 866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKISNDCEL 920
++ +L+ ++ +++ LGN+ L+ + FIF ++G+QL+ + + E I D L
Sbjct: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253
Query: 921 PRWH 924
P ++
Sbjct: 254 PPYY 257
Score = 57.0 bits (136), Expect = 2e-07
Identities = 49/163 (30%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 1533 FDISIMILICLNMVT--MMVETDDQS--QEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
F+ M++I LN VT M DD + IL + + F E VLK+++L +
Sbjct: 81 FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
Y WN DF +V+ +V L + IR R+ R L+ I
Sbjct: 141 GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A + R
Sbjct: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
Score = 49.7 bits (117), Expect = 3e-05
Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 14/129 (10%)
Query: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 412
+ +F+ F AFL+LF++ T D W + + TLR + ++FV +
Sbjct: 1658 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1717
Query: 413 SFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
F LIN+++AV+ ++ N+ E+AE +AE + LE + + A R
Sbjct: 1718 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE--LEMAHGLGPGPRLPTGSPGAPGR 1774
Query: 473 DFSGAGGIG 481
GAGG G
Sbjct: 1775 GPGGAGGGG 1783
Score = 48.1 bits (113), Expect = 8e-05
Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)
Query: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
+FD+ WA +++F+++TQ+ W + + + ++FV ++ G++ L NL++A++
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
Query: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 458
++ + A +++ ++ +E+ K QE
Sbjct: 863 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 893
Score = 33.1 bits (74), Expect = 2.8
Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 930 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987
++++++F+V+ E W+E M+ M+ A F++++++G+ ++NL L ++ + FS
Sbjct: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 337 bits (864), Expect = 7e-92
Identities = 194/611 (31%), Positives = 341/611 (55%), Gaps = 38/611 (6%)
Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
R +C K++ H F+ ++ I L+ +A E I+ T + L ++ +FT IF+ EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343
Query: 1258 LLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1310
++K VA G Y ++W LD L+V VSLV + A+A G LG ++ LR LR
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GV LF GKFY+C
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC---- 1459
Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
E D ++ ++C+A RW K NFDN+G +SL +++ GW++IMY
Sbjct: 1460 --EGPDTRNISTKAQCRAA-----HYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYD 1512
Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
+D+ V+ QP N +M LYF+ F++ SFF LN+F+GV+++NF++ ++ ++
Sbjct: 1513 GLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1572
Query: 1491 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV 1550
EE K +++ K ++P + + + T D+ I +IC+N++TM +
Sbjct: 1573 REE--KRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSM 1630
Query: 1551 ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGM 1609
E +Q + + L + N VF ++F E LKL++ + +F WN D +V+LS++G+
Sbjct: 1631 EHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI 1690
Query: 1610 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1667
L E+ ++PT+ R++R+ RI R+L+L+K A G+R LL ++ +LP + N+GLL
Sbjct: 1691 TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1750
Query: 1668 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1722
L+ FIYA G+ F ++ G+ F FG + + LF+++T W+G++
Sbjct: 1751 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKD 1810
Query: 1723 ILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1782
L +C + H S + P++ +FV++++++ V+VN+ +AV++++ +
Sbjct: 1811 TLR----ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEES 1860
Query: 1783 TEESAEPLSED 1793
+E+ E D
Sbjct: 1861 NKEAREDAELD 1871
Score = 136 bits (342), Expect = 2e-31
Identities = 83/262 (31%), Positives = 138/262 (52%), Gaps = 17/262 (6%)
Query: 745 WLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTA 804
W+ + +V + I + I++NTL M +E++ E+ ++ L + N+VFT +F
Sbjct: 779 WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838
Query: 805 EMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSW 864
EM LK++A P Y + +NIFDG IV +S+ E+ GLSVLR+FRLLRV KL +
Sbjct: 839 EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898
Query: 865 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIS-----NDCE 919
P L + ++ ++ + +L + +FIF+++GM LFG CK S D
Sbjct: 899 PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFG-------CKFSLKTDTGDTV 951
Query: 920 LPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLF 978
R + + + VF++L E W +++ M L F+ +M GN V+ NL
Sbjct: 952 PDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAAL-YFVALMTFGNYVLFNLL 1010
Query: 979 LALLLSSFSSD---NLAATDDD 997
+A+L+ F ++ N + TD+D
Sbjct: 1011 VAILVEGFQAEGDANRSDTDED 1032
Score = 122 bits (306), Expect = 4e-27
Identities = 90/356 (25%), Positives = 168/356 (47%), Gaps = 37/356 (10%)
Query: 119 RKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTK------NVEYTFTGI----YTF 168
R ++++ + F + M I+ NCV + M P + + N+ F +
Sbjct: 90 RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAV 149
Query: 169 ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 226
E +IK++A G + +L D WN LDF ++ + +D NVS A+RT RVLR L+
Sbjct: 150 EMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLR 208
Query: 227 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNS 286
I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LRN+C D++
Sbjct: 209 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL---DSA 265
Query: 287 SFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALL-CGNSSDAG 345
N +F N + D ++ SH + G+ + + C +A
Sbjct: 266 FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSH---IPGRRELRMPCTLGWEAY 322
Query: 346 QCPEG-----------------YICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWEN 388
P+ +C NP+ G +FD +A++++F+++T + W +
Sbjct: 323 TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
Query: 389 LYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEA 444
+ + A I+F+L+I +GSF++INL L V+A + E Q + ++ A
Sbjct: 383 IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRA 438
Score = 115 bits (287), Expect = 6e-25
Identities = 94/382 (24%), Positives = 162/382 (42%), Gaps = 93/382 (24%)
Query: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP---PDWTKNV-----E 159
ALY+ +P N R K++ H +F+ +++ I NCV + + P P T+ V
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332
Query: 160 YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------L 210
Y FT I+ E ++K++A G + +L+ WN LD ++ + V V L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392
Query: 211 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
G + LR R LR L+ IS PGLK +V LI S++ + +++++ +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452
Query: 271 MGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLE 330
G FY+ E
Sbjct: 1453 KGK----------------------------------------------------FYYCE 1460
Query: 331 GQNDALLCGNSSDAGQCPEG-YICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENL 389
G + N S QC Y V+ N FD A +SLF L ++D W N+
Sbjct: 1461 GPDTR----NISTKAQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNI 1509
Query: 390 YQLTLRAAG----------KTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEA 439
L A G +++F+ + + SF+++N+ + VV + + Q +EA
Sbjct: 1510 MYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEA 1567
Query: 440 EQKEAEFQQMLEQLKKQQEEAQ 461
E+ ++ L +L++++ +AQ
Sbjct: 1568 EEARRREEKRLRRLERRRRKAQ 1589
Score = 110 bits (275), Expect = 1e-23
Identities = 77/260 (29%), Positives = 127/260 (48%), Gaps = 27/260 (10%)
Query: 760 FVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYF 819
++DL IT I +N + M+MEHY + L N VFT +F E LK++A +F
Sbjct: 1612 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1671
Query: 820 QEGWNIFDGFIVSLSLMELGLANVEG----------LSVLRSFRLLRVFKLAKSWPTLNM 869
++ WN D IV LSLM + L +E + ++R R+ RV KL K +
Sbjct: 1672 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1731
Query: 870 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH--MHD 927
L+ + ++ +GNL L+ ++ FI+A +G++LFG+ C N CE H +
Sbjct: 1732 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGLSRHATFSN 1787
Query: 928 FFHSFLIVFRVLCGE-WIETMWDCMEVAGQ--TMCLT--------VFMMVMVIGNLVVLN 976
F +FL +FRV G+ W M D + + CL+ F+ +++ V++N
Sbjct: 1788 FGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1847
Query: 977 LFLALLLSSFSSDNLAATDD 996
+ +A+L+ N A +D
Sbjct: 1848 VVVAVLMKHLEESNKEARED 1867
Score = 102 bits (254), Expect = 4e-21
Identities = 75/291 (25%), Positives = 142/291 (48%), Gaps = 38/291 (13%)
Query: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTN--ILYWINLVFIVL 1573
P N+F+ +T ++FD +++ I LN VT+ +E D T L N +F +
Sbjct: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338
Query: 1574 FTGECVLKLISL-----RYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628
F E ++K+++L + Y WN+ D ++V++S+V + +A + RV+
Sbjct: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398
Query: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAY 1684
RL R R LR+I A G++ ++ L+ SL + NI L+ I+ I G+ F Y
Sbjct: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458
Query: 1685 VK----REVG------------IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
+ R + + +NF+ G +++ LF +++ GW ++ L++
Sbjct: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518
Query: 1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779
D P ++H NP + + +F+S+++I V+NM++ V++ENF
Sbjct: 1519 VDQQPVQNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558
Score = 95.5 bits (236), Expect = 5e-19
Identities = 74/270 (27%), Positives = 132/270 (48%), Gaps = 39/270 (14%)
Query: 755 VVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTGIFTAEMFLKII 811
V+ D + + I LN + +A+E P + S+ LSV N +FT IF AEM +K++
Sbjct: 1290 VITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348
Query: 812 AMD----PYYYFQEGWNIFDGFIVSLSLMEL-------GLANVEG-LSVLRSFRLLRVFK 859
A+ + Y Q WN+ DG +V +SL+++ G A + G L VLR R LR +
Sbjct: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408
Query: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY----------- 907
+ P L ++++ + +S+ +GN+ L+ IF ++G+QLF GK Y
Sbjct: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468
Query: 908 KECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGE--WIETMWDCMEVAG---------Q 956
+ C+ ++ + R + D L+ VL + W+ M+D ++ G
Sbjct: 1469 TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528
Query: 957 TMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
L F+ ++I + VLN+F+ +++ +F
Sbjct: 1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558
Score = 94.4 bits (233), Expect = 1e-18
Identities = 73/289 (25%), Positives = 133/289 (46%), Gaps = 43/289 (14%)
Query: 1191 GKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1250
G+LW +IV+ +F I+ IL+++ ++ E Y EQ + + LE ++ VFT
Sbjct: 776 GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833
Query: 1251 YIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1310
+F LEMLLK +A G Y N + D +IV +S+ + A G + LRT R
Sbjct: 834 SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA-----DGGLSVLRTFRL 888
Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
LR L+ + +R + L+ + ++ + ++F IFSI+G++LF KF +
Sbjct: 889 LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF--SLKTD 946
Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
TG+ + NFD++ +++ Q+ T + W ++Y
Sbjct: 947 TGDTVP------------------------DRKNFDSLLWAIVTVFQILTQEDWNVVLYN 982
Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1479
+ S + + LYFV + FG++ NL + ++++ F +
Sbjct: 983 GMAS----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
Score = 94.0 bits (232), Expect = 1e-18
Identities = 76/290 (26%), Positives = 133/290 (45%), Gaps = 41/290 (14%)
Query: 1520 FQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECV 1579
F G + V + F IM+ I +N ++M VE +Q +E+TN L N+VF +F E +
Sbjct: 782 FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841
Query: 1580 LKLISL-RYYYFTIGWNIFDFVVVILS---IVGMFLAELIEKYFVSPTLFRVIRLARIGR 1635
LKL++ Y +NIFD ++V++S IVG L V+R R+ R
Sbjct: 842 LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLR 890
Query: 1636 ILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG-- 1690
+L+L++ +R L L+ ++ + LL L +FI++I GM F +K + G
Sbjct: 891 VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950
Query: 1691 IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPS 1750
+ D NF++ +++ +FQI T W+ +L G S
Sbjct: 951 VPDRKNFDSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSS 989
Query: 1751 VGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800
+FV+ + V+ N+ +A+++E F + + ED + +E
Sbjct: 990 WAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
Score = 93.2 bits (230), Expect = 2e-18
Identities = 58/171 (33%), Positives = 92/171 (53%), Gaps = 13/171 (7%)
Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1253
R C ++V + WFE + +I+L+ L ED+ + +LE D F
Sbjct: 90 RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147
Query: 1254 ILEMLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1310
+EM++K VA +G + Y + W LDF IV ++ + + S + ++RT+R
Sbjct: 148 AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVS----LSAIRTVRV 203
Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
LRPLRA++R MR++V LL +P + NVLL+C + IF I+GV L+AG
Sbjct: 204 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
Score = 72.4 bits (176), Expect = 4e-12
Identities = 39/132 (29%), Positives = 70/132 (53%), Gaps = 13/132 (9%)
Query: 1400 NVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIF 1459
N +NFDN+G ++++ QV T +GW+DIMY +D+ + Y ++YF++ II
Sbjct: 356 NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAH----------SFYNFIYFILLIIV 405
Query: 1460 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANK 1519
GSFF +NL + VI F++ K++ + M E++ ++ + L S K
Sbjct: 406 GSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLK 462
Query: 1520 FQGMVFDFVTKQ 1531
+ G +F V ++
Sbjct: 463 YVGHIFRKVKRR 474
Score = 69.7 bits (169), Expect = 3e-11
Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 15/166 (9%)
Query: 742 CKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGI 801
C PW + H+ LV+M C+ L +F E + ++L +
Sbjct: 98 CNPWFE--HVSMLVIM--------LNCVTLG-MFRPCEDVECGSERCNILEAFDAFIFAF 146
Query: 802 FTAEMFLKIIAMDPY---YYFQEGWNIFDGFIVSLSLMELGL-ANVEGLSVLRSFRLLRV 857
F EM +K++A+ + Y + WN D FIV +ME L + LS +R+ R+LR
Sbjct: 147 FAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRP 206
Query: 858 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
+ P++ +L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 207 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
Score = 67.4 bits (163), Expect = 1e-10
Identities = 54/208 (25%), Positives = 100/208 (48%), Gaps = 20/208 (9%)
Query: 124 KILVHSLFNMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 177
+I+ F+ IM IL N + M + P + T +E + FT ++ E L+K+LA
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847
Query: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 235
G ++R+P+N D ++ + V E V G +S LRTFR+LR LK + +P L+
Sbjct: 848 G----PLGYIRNPYNIFDGIIVVIS-VWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902
Query: 236 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF--MGNLRNKCLQWPPDNSSFEINIT 293
+ L++++ ++ L + + +F+++G+ LF +L+ PD +F+ +
Sbjct: 903 RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLW 962
Query: 294 SFFN-----NSLDGNGTTFNRTVSIFNW 316
+ D N +N S +W
Sbjct: 963 AIVTVFQILTQEDWNVVLYNGMASTSSW 990
Score = 63.5 bits (153), Expect = 2e-09
Identities = 39/173 (22%), Positives = 85/173 (49%), Gaps = 21/173 (12%)
Query: 115 FNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMS--NPP----DWTKNVEYTFTGIYTF 168
++P R+ + ++ I I N + M+M N P + K Y FT ++ F
Sbjct: 1597 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1656
Query: 169 ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LR 217
E+ +K++A GF F +D WN LD ++ + + ++ +SA +R
Sbjct: 1657 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1712
Query: 218 TFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
R+ R LK + + G++ ++ ++Q++ ++ ++ +L + ++A +G++LF
Sbjct: 1713 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1765
Score = 60.1 bits (144), Expect = 2e-08
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 15/163 (9%)
Query: 1533 FDISIMILICLNMVTMMV----ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
F+ M++I LN VT+ + E + E NIL + F E V+K+++L +
Sbjct: 102 FEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLF 161
Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
Y WN DF +V+ ++ L + + VS IR R+ R LR I
Sbjct: 162 GQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLRAINRVP 214
Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A + R
Sbjct: 215 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 257
Score = 54.3 bits (129), Expect = 1e-06
Identities = 35/118 (29%), Positives = 59/118 (50%), Gaps = 17/118 (14%)
Query: 346 QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK------ 399
+C E C R + +F F AFL+LFR+ T D W + + TLR +
Sbjct: 1769 ECSEDNPCEGLSR-----HATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCL 1823
Query: 400 TYM-----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQ 452
+Y+ ++FV + + F L+N+++AV+ EE N+ E+AE +AE + + Q
Sbjct: 1824 SYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAE-LDAEIELEMAQ 1880
Score = 50.4 bits (119), Expect = 2e-05
Identities = 22/117 (18%), Positives = 59/117 (50%), Gaps = 2/117 (1%)
Query: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
+FD+ WA +++F+++TQ+ W + + + ++FV ++ G++ L NL++A++
Sbjct: 956 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015
Query: 426 MAYEEQNQATLEEAEQKE--AEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
++ + A + ++ + F++ +L++ Q + A + G G +
Sbjct: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSL 1072
Score = 32.7 bits (73), Expect = 3.7
Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)
Query: 1696 NFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFF 1755
NF+ G + I +FQ+ T GW ++ ++++ + +
Sbjct: 360 NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA---------------------HSFYNFIY 398
Query: 1756 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1792
F+ II+ ++N+ + VI FS + ++ + E
Sbjct: 399 FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 333 bits (854), Expect = 1e-90
Identities = 200/612 (32%), Positives = 341/612 (55%), Gaps = 46/612 (7%)
Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
R C++I+ H F+ ++ +I L+ +A E I+ + L ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1258 LLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1310
+K VA G+ Q Y ++W LD L+V +S++ + + + G LG ++ LR LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF+ C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1418
Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
GE D + N S+C + + RW K NFDN+G +SL +A+ GW+DIMY
Sbjct: 1419 QGE--DTRNITNKSDC-----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1471
Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
+D+ V+ QP N +M LYF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1530
Query: 1491 TEEQKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTKQVFDISIMILICLN 1544
E+K+ KK SK+ Q KP ++F+ +V T D+ I +I LN
Sbjct: 1531 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1590
Query: 1545 MVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVI 1603
+VTM +E Q Q + L N +F V+F E V KL++ + +F WN D +V+
Sbjct: 1591 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1650
Query: 1604 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661
LSI+G+ L E+ ++PT+ R++R+ RI R+L+L+K A G+R LL +M +LP +
Sbjct: 1651 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1710
Query: 1662 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1716
N+GLL L+ FI+A G+ F ++ + G+ F FG + + LF+++T W
Sbjct: 1711 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1770
Query: 1717 DGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1776
+G++ L DCD + C N + +FVS+++ + V+VN+ IAV++
Sbjct: 1771 NGIMKDTLR----DCDQE---------STCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817
Query: 1777 ENFSVATEESAE 1788
++ + +E+ E
Sbjct: 1818 KHLEESNKEAKE 1829
Score = 135 bits (340), Expect = 4e-31
Identities = 78/250 (31%), Positives = 137/250 (54%), Gaps = 13/250 (5%)
Query: 745 WLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTA 804
W + +V + I I I++NTL M +E++ E+ ++ L + N+VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 805 EMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSW 864
EM LK++ P+ Y + +NIFDG IV +S+ E+ GLSVLR+FRL+RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 865 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCE---LP 921
P L + ++ ++ + ++L + +FIF+++GM LFG CK +++ + LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901
Query: 922 -RWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFL 979
R + + + VF++L E W + +++ M L F+ +M GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAAL-YFIALMTFGNYVLFNLLV 960
Query: 980 ALLLSSFSSD 989
A+L+ F ++
Sbjct: 961 AILVEGFQAE 970
Score = 122 bits (307), Expect = 3e-27
Identities = 96/355 (27%), Positives = 169/355 (47%), Gaps = 36/355 (10%)
Query: 119 RKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 168
R ++ + + F + M IL NCV + M P + + + +
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
Query: 169 ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 226
E ++K++A G + +L D WN LDF ++ + +DL NVS A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
Query: 227 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNS 286
I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LRN+C + P+N
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247
Query: 287 SFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIED-----KSHFYFLEGQNDALLCG-- 339
S +++ L+ T N S F + E+ +S CG
Sbjct: 248 SLPLSV------DLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLD 301
Query: 340 ----NSSDAGQC---PEGYICVKAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQ 391
NSS C + Y AG NP G +FD +A++++F+++T + W ++
Sbjct: 302 YEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMY 361
Query: 392 LTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 446
+ A I+F+L+I +GSF++INL L V+A + E Q + ++ F
Sbjct: 362 FVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
Score = 114 bits (286), Expect = 7e-25
Identities = 137/678 (20%), Positives = 276/678 (40%), Gaps = 122/678 (17%)
Query: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
+FD+ WA +++F+++TQ+ W + + + ++F+ ++ G++ L NL++A++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSE 485
++ + +A + E+E L + + A + E + + +
Sbjct: 965 EGFQAEG-----DANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1019
Query: 486 SSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSR 545
+++ L + L ++ S + + +S S R
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR------------ 1067
Query: 546 LTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDI--------------GSEN 591
SSPH + S ++ RR+SR SL GRA + G
Sbjct: 1068 -------SSPHSPWSA--ASSWTSRRSSRNSL----GRAPSLKRRSPSGERRSLLSGEGQ 1114
Query: 592 DFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCN 651
+ D+E S+ E+ S S HRH ++ + +++S LP +H
Sbjct: 1115 ESQDEEESSEEERASPAGS---DHRH----RGSLEREAKSSFDLPDTLQVPGLHRTASGR 1167
Query: 652 GVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASIL 711
G S + +++G+L R R + D +D + + + + +
Sbjct: 1168 GSASEHQDCNGKSASGRLA----------RALRPDDPPLDGDDADDEGNLSKGERVRAWI 1217
Query: 712 TNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWL-----KVKHLVNLVVMDPFVDLAIT 766
R + P C CL D ++ + + L + ++ D +
Sbjct: 1218 ----------RARLPAC-------CLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
Query: 767 ICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTGIFTAEMFLKIIAMDPYY----YF 819
+ I LN + +AME P + S+ L++ N +FT +F AEM +K++A+ + Y
Sbjct: 1261 VIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYL 1319
Query: 820 QEGWNIFDGFIVSLSLMELGLANVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLI 871
+ WN+ DG +V +S++++ ++ V L VLR R LR ++ L +++
Sbjct: 1320 RSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVV 1379
Query: 872 KIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC----VCKISN--DCELP--RW 923
+ + +S+ +GN+ ++ IF ++G+QLF + C I+N DC RW
Sbjct: 1380 ETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRW 1439
Query: 924 HMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVAG---------QTMCLTVFMMVMV 968
H D L+ VL + W++ M+D ++ G L F+ ++
Sbjct: 1440 VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL 1499
Query: 969 IGNLVVLNLFLALLLSSF 986
I VLN+F+ +++ +F
Sbjct: 1500 IVAFFVLNMFVGVVVENF 1517
Score = 112 bits (281), Expect = 3e-24
Identities = 82/279 (29%), Positives = 136/279 (48%), Gaps = 28/279 (10%)
Query: 742 CKPWL----KVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
CKP+ + + LV+ + ++DL IT I LN + MAMEHY + L + N +
Sbjct: 1556 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615
Query: 798 FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG----------LS 847
FT IF E K++A +FQ+ WN D IV LS+M + L +E +
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675
Query: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 907
++R R+ RV KL K + L+ + ++ +GNL L+ ++ FIFA +G++LFG
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1732
Query: 908 KECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-TMCLTV- 962
+ C ++ CE H +F +FL +FRV G+ W M D + Q + C
Sbjct: 1733 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1791
Query: 963 -----FMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDD 996
F+ ++ V++N+ +A+L+ N A ++
Sbjct: 1792 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830
Score = 107 bits (266), Expect = 2e-22
Identities = 87/393 (22%), Positives = 159/393 (40%), Gaps = 89/393 (22%)
Query: 110 YILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 161
YI P + R L +I+ H +F+ +++ I NC+ + M P + E Y
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Query: 162 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 212
FT ++ E +K++A G+C + +LR WN LD ++ + + V LG
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
Query: 213 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
+ LR R LR L+ IS GLK +V L+ S+K + +++++ +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Query: 273 NLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQ 332
F+ +G+
Sbjct: 1414 K----------------------------------------------------FFVCQGE 1421
Query: 333 NDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQL 392
D N SD + ++ K Y + D A +SLF L ++D W ++
Sbjct: 1422 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1471
Query: 393 TLRAAG----------KTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK 442
L A G +++F+ + + +F+++N+ + VV + + Q EE ++
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Query: 443 EAEFQQMLEQLKKQQEEAQAAAAAASAESRDFS 475
E + + K++ +E Q A A D+S
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1564
Score = 94.0 bits (232), Expect = 1e-18
Identities = 59/171 (34%), Positives = 95/171 (55%), Gaps = 13/171 (7%)
Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1253
R C + V + WFE + +ILL+ L EDI + ++ + + + D +F + F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128
Query: 1254 ILEMLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1310
+EM++K VA +G + Y + W LDF IV ++ + + S ++RT+R
Sbjct: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS----FSAVRTVRV 184
Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
LRPLRA++R MR++V LL +P + NVLL+C + IF I+GV L+AG
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 91.7 bits (226), Expect = 7e-18
Identities = 84/315 (26%), Positives = 145/315 (46%), Gaps = 47/315 (14%)
Query: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISL-R 1586
V + F IMI I +N ++M +E +Q +E+TN L N+VF LF E +LKL+
Sbjct: 740 VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799
Query: 1587 YYYFTIGWNIFDFVVVILS---IVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1643
+ Y +NIFD V+V++S IVG L V+R R+ R+L+L++
Sbjct: 800 FGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRFL 848
Query: 1644 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKREVGIDDMFNFET 1699
++ L LM ++ + +LL L +FI++I GM FA + + D NF++
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
Query: 1700 FGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSY 1759
+++ +FQI T W+ +L G S +F++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIAL 947
Query: 1760 IIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLS 1819
+ V+ N+ +A+++E F A ++ + SE D F+ D D + + L
Sbjct: 948 MTFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPD---FFSPSLDGDGDRKKCLALVSLG 1003
Query: 1820 DFAD---ALDPPLLI 1831
+ + +L PPL+I
Sbjct: 1004 EHPELRKSLLPPLII 1018
Score = 90.9 bits (224), Expect = 1e-17
Identities = 68/286 (23%), Positives = 131/286 (45%), Gaps = 44/286 (15%)
Query: 1194 WWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1253
W + T KIV+ +F I+ IL+++ ++ E Y EQ + + LE ++ VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
Query: 1254 ILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
LEMLLK + YG Y N + D +IV +S+ + + G + LRT R +R
Sbjct: 787 ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRV 841
Query: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGE 1373
L+ + ++ + L+ + ++ ++ ++F IFSI+G++LF KF
Sbjct: 842 LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---------- 891
Query: 1374 MFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVD 1433
S + + NFD++ +++ Q+ T + W ++Y +
Sbjct: 892 -----------------ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMA 934
Query: 1434 SRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1479
S + + LYF+ + FG++ NL + ++++ F +
Sbjct: 935 S----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 71.2 bits (173), Expect = 9e-12
Identities = 34/104 (32%), Positives = 61/104 (58%), Gaps = 13/104 (12%)
Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
+NFDN+G ++++ QV T +GW+DIMY +D+ + Y ++YF++ II GSF
Sbjct: 335 INFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSF 384
Query: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
F +NL + VI F++ K++ + M E++ ++ + L S
Sbjct: 385 FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
Score = 66.6 bits (161), Expect = 2e-10
Identities = 44/155 (28%), Positives = 83/155 (53%), Gaps = 13/155 (8%)
Query: 124 KILVHSLFNMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 177
KI+ F IM IL N + M + P + T +E + FT ++ E L+K+L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
Query: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 235
G F ++++P+N D ++ + V E V G +S LRTFR++R LK + +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
Query: 236 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
+ L++++ ++ +L + + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 63.9 bits (154), Expect = 1e-09
Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 10/157 (6%)
Query: 756 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKII 811
V +P+ + + I+LN + + M E Q +L + F EM +K++
Sbjct: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
Query: 812 AMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 866
A+ + Y + WN D FIV ++E L L NV S +R+ R+LR + P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196
Query: 867 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
+ +L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 59.3 bits (142), Expect = 4e-08
Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)
Query: 346 QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 402
+C E + C GR + +F F AFL+LFR+ T D W + + TLR +
Sbjct: 1735 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789
Query: 403 -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQ 456
I+FV + F L+N+++AV+ EE N+ EEAE EAE + ++ L Q
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1847
Score = 58.2 bits (139), Expect = 8e-08
Identities = 42/169 (24%), Positives = 82/169 (48%), Gaps = 26/169 (15%)
Query: 124 KILVHSL-----FNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 172
++LVH L ++ I I N V M M + + K Y FT I+ ES+
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626
Query: 173 KILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 221
K++A GF F +D WN LD ++ + + ++ V+A +R R+
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
Query: 222 LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
R LK + + G++ ++ ++Q++ ++ ++ +L + +FA +G++LF
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731
Score = 55.8 bits (133), Expect = 4e-07
Identities = 47/163 (28%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 1533 FDISIMILICLNMVTMMV----ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
F+ M++I LN VT+ + E + IL + F E V+K+++L +
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
Y WN DF +VI ++ L + F +R R+ R LR I
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195
Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A + R
Sbjct: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238
Score = 32.3 bits (72), Expect = 4.8
Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)
Query: 1696 NFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFF 1755
NF+ G + I +FQ+ T GW ++ ++++ + +
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374
Query: 1756 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1792
F+ II+ ++N+ + VI FS + ++ + E
Sbjct: 375 FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 333 bits (854), Expect = 1e-90
Identities = 200/612 (32%), Positives = 341/612 (55%), Gaps = 46/612 (7%)
Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
R C++I+ H F+ ++ +I L+ +A E I+ + L ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1258 LLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1310
+K VA G+ Q Y ++W LD L+V +S++ + + + G LG ++ LR LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF+ C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1418
Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
GE D + N S+C + + RW K NFDN+G +SL +A+ GW+DIMY
Sbjct: 1419 QGE--DTRNITNKSDC-----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1471
Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
+D+ V+ QP N +M LYF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1530
Query: 1491 TEEQKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTKQVFDISIMILICLN 1544
E+K+ KK SK+ Q KP ++F+ +V T D+ I +I LN
Sbjct: 1531 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1590
Query: 1545 MVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVI 1603
+VTM +E Q Q + L N +F V+F E V KL++ + +F WN D +V+
Sbjct: 1591 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1650
Query: 1604 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661
LSI+G+ L E+ ++PT+ R++R+ RI R+L+L+K A G+R LL +M +LP +
Sbjct: 1651 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1710
Query: 1662 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1716
N+GLL L+ FI+A G+ F ++ + G+ F FG + + LF+++T W
Sbjct: 1711 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1770
Query: 1717 DGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1776
+G++ L DCD + C N + +FVS+++ + V+VN+ IAV++
Sbjct: 1771 NGIMKDTLR----DCDQE---------STCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817
Query: 1777 ENFSVATEESAE 1788
++ + +E+ E
Sbjct: 1818 KHLEESNKEAKE 1829
Score = 135 bits (340), Expect = 4e-31
Identities = 78/250 (31%), Positives = 137/250 (54%), Gaps = 13/250 (5%)
Query: 745 WLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTA 804
W + +V + I I I++NTL M +E++ E+ ++ L + N+VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 805 EMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSW 864
EM LK++ P+ Y + +NIFDG IV +S+ E+ GLSVLR+FRL+RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 865 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCE---LP 921
P L + ++ ++ + ++L + +FIF+++GM LFG CK +++ + LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901
Query: 922 -RWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFL 979
R + + + VF++L E W + +++ M L F+ +M GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAAL-YFIALMTFGNYVLFNLLV 960
Query: 980 ALLLSSFSSD 989
A+L+ F ++
Sbjct: 961 AILVEGFQAE 970
Score = 122 bits (307), Expect = 3e-27
Identities = 96/355 (27%), Positives = 169/355 (47%), Gaps = 36/355 (10%)
Query: 119 RKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 168
R ++ + + F + M IL NCV + M P + + + +
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
Query: 169 ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 226
E ++K++A G + +L D WN LDF ++ + +DL NVS A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
Query: 227 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNS 286
I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LRN+C + P+N
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247
Query: 287 SFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIED-----KSHFYFLEGQNDALLCG-- 339
S +++ L+ T N S F + E+ +S CG
Sbjct: 248 SLPLSV------DLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLD 301
Query: 340 ----NSSDAGQC---PEGYICVKAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQ 391
NSS C + Y AG NP G +FD +A++++F+++T + W ++
Sbjct: 302 YEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMY 361
Query: 392 LTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 446
+ A I+F+L+I +GSF++INL L V+A + E Q + ++ F
Sbjct: 362 FVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
Score = 114 bits (286), Expect = 7e-25
Identities = 137/678 (20%), Positives = 276/678 (40%), Gaps = 122/678 (17%)
Query: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
+FD+ WA +++F+++TQ+ W + + + ++F+ ++ G++ L NL++A++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSE 485
++ + +A + E+E L + + A + E + + +
Sbjct: 965 EGFQAEG-----DANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1019
Query: 486 SSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSR 545
+++ L + L ++ S + + +S S R
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR------------ 1067
Query: 546 LTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDI--------------GSEN 591
SSPH + S ++ RR+SR SL GRA + G
Sbjct: 1068 -------SSPHSPWSA--ASSWTSRRSSRNSL----GRAPSLKRRSPSGERRSLLSGEGQ 1114
Query: 592 DFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCN 651
+ D+E S+ E+ S S HRH ++ + +++S LP +H
Sbjct: 1115 ESQDEEESSEEERASPAGS---DHRH----RGSLEREAKSSFDLPDTLQVPGLHRTASGR 1167
Query: 652 GVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASIL 711
G S + +++G+L R R + D +D + + + + +
Sbjct: 1168 GSASEHQDCNGKSASGRLA----------RALRPDDPPLDGDDADDEGNLSKGERVRAWI 1217
Query: 712 TNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWL-----KVKHLVNLVVMDPFVDLAIT 766
R + P C CL D ++ + + L + ++ D +
Sbjct: 1218 ----------RARLPAC-------CLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
Query: 767 ICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTGIFTAEMFLKIIAMDPYY----YF 819
+ I LN + +AME P + S+ L++ N +FT +F AEM +K++A+ + Y
Sbjct: 1261 VIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYL 1319
Query: 820 QEGWNIFDGFIVSLSLMELGLANVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLI 871
+ WN+ DG +V +S++++ ++ V L VLR R LR ++ L +++
Sbjct: 1320 RSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVV 1379
Query: 872 KIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC----VCKISN--DCELP--RW 923
+ + +S+ +GN+ ++ IF ++G+QLF + C I+N DC RW
Sbjct: 1380 ETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRW 1439
Query: 924 HMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVAG---------QTMCLTVFMMVMV 968
H D L+ VL + W++ M+D ++ G L F+ ++
Sbjct: 1440 VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL 1499
Query: 969 IGNLVVLNLFLALLLSSF 986
I VLN+F+ +++ +F
Sbjct: 1500 IVAFFVLNMFVGVVVENF 1517
Score = 112 bits (281), Expect = 3e-24
Identities = 82/279 (29%), Positives = 136/279 (48%), Gaps = 28/279 (10%)
Query: 742 CKPWL----KVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
CKP+ + + LV+ + ++DL IT I LN + MAMEHY + L + N +
Sbjct: 1556 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615
Query: 798 FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG----------LS 847
FT IF E K++A +FQ+ WN D IV LS+M + L +E +
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675
Query: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 907
++R R+ RV KL K + L+ + ++ +GNL L+ ++ FIFA +G++LFG
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1732
Query: 908 KECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-TMCLTV- 962
+ C ++ CE H +F +FL +FRV G+ W M D + Q + C
Sbjct: 1733 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1791
Query: 963 -----FMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDD 996
F+ ++ V++N+ +A+L+ N A ++
Sbjct: 1792 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830
Score = 107 bits (266), Expect = 2e-22
Identities = 87/393 (22%), Positives = 159/393 (40%), Gaps = 89/393 (22%)
Query: 110 YILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 161
YI P + R L +I+ H +F+ +++ I NC+ + M P + E Y
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Query: 162 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 212
FT ++ E +K++A G+C + +LR WN LD ++ + + V LG
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
Query: 213 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
+ LR R LR L+ IS GLK +V L+ S+K + +++++ +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Query: 273 NLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQ 332
F+ +G+
Sbjct: 1414 K----------------------------------------------------FFVCQGE 1421
Query: 333 NDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQL 392
D N SD + ++ K Y + D A +SLF L ++D W ++
Sbjct: 1422 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1471
Query: 393 TLRAAG----------KTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK 442
L A G +++F+ + + +F+++N+ + VV + + Q EE ++
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Query: 443 EAEFQQMLEQLKKQQEEAQAAAAAASAESRDFS 475
E + + K++ +E Q A A D+S
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1564
Score = 94.0 bits (232), Expect = 1e-18
Identities = 59/171 (34%), Positives = 95/171 (55%), Gaps = 13/171 (7%)
Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1253
R C + V + WFE + +ILL+ L EDI + ++ + + + D +F + F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128
Query: 1254 ILEMLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1310
+EM++K VA +G + Y + W LDF IV ++ + + S ++RT+R
Sbjct: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS----FSAVRTVRV 184
Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
LRPLRA++R MR++V LL +P + NVLL+C + IF I+GV L+AG
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 91.7 bits (226), Expect = 7e-18
Identities = 84/315 (26%), Positives = 145/315 (46%), Gaps = 47/315 (14%)
Query: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISL-R 1586
V + F IMI I +N ++M +E +Q +E+TN L N+VF LF E +LKL+
Sbjct: 740 VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799
Query: 1587 YYYFTIGWNIFDFVVVILS---IVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1643
+ Y +NIFD V+V++S IVG L V+R R+ R+L+L++
Sbjct: 800 FGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRFL 848
Query: 1644 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKREVGIDDMFNFET 1699
++ L LM ++ + +LL L +FI++I GM FA + + D NF++
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
Query: 1700 FGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSY 1759
+++ +FQI T W+ +L G S +F++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIAL 947
Query: 1760 IIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLS 1819
+ V+ N+ +A+++E F A ++ + SE D F+ D D + + L
Sbjct: 948 MTFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPD---FFSPSLDGDGDRKKCLALVSLG 1003
Query: 1820 DFAD---ALDPPLLI 1831
+ + +L PPL+I
Sbjct: 1004 EHPELRKSLLPPLII 1018
Score = 90.9 bits (224), Expect = 1e-17
Identities = 68/286 (23%), Positives = 131/286 (45%), Gaps = 44/286 (15%)
Query: 1194 WWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1253
W + T KIV+ +F I+ IL+++ ++ E Y EQ + + LE ++ VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
Query: 1254 ILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
LEMLLK + YG Y N + D +IV +S+ + + G + LRT R +R
Sbjct: 787 ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRV 841
Query: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGE 1373
L+ + ++ + L+ + ++ ++ ++F IFSI+G++LF KF
Sbjct: 842 LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---------- 891
Query: 1374 MFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVD 1433
S + + NFD++ +++ Q+ T + W ++Y +
Sbjct: 892 -----------------ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMA 934
Query: 1434 SRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1479
S + + LYF+ + FG++ NL + ++++ F +
Sbjct: 935 S----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 71.2 bits (173), Expect = 9e-12
Identities = 34/104 (32%), Positives = 61/104 (58%), Gaps = 13/104 (12%)
Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
+NFDN+G ++++ QV T +GW+DIMY +D+ + Y ++YF++ II GSF
Sbjct: 335 INFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSF 384
Query: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
F +NL + VI F++ K++ + M E++ ++ + L S
Sbjct: 385 FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
Score = 66.6 bits (161), Expect = 2e-10
Identities = 44/155 (28%), Positives = 83/155 (53%), Gaps = 13/155 (8%)
Query: 124 KILVHSLFNMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 177
KI+ F IM IL N + M + P + T +E + FT ++ E L+K+L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
Query: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 235
G F ++++P+N D ++ + V E V G +S LRTFR++R LK + +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
Query: 236 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
+ L++++ ++ +L + + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 63.9 bits (154), Expect = 1e-09
Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 10/157 (6%)
Query: 756 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKII 811
V +P+ + + I+LN + + M E Q +L + F EM +K++
Sbjct: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
Query: 812 AMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 866
A+ + Y + WN D FIV ++E L L NV S +R+ R+LR + P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196
Query: 867 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
+ +L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 59.3 bits (142), Expect = 4e-08
Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)
Query: 346 QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 402
+C E + C GR + +F F AFL+LFR+ T D W + + TLR +
Sbjct: 1735 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789
Query: 403 -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQ 456
I+FV + F L+N+++AV+ EE N+ EEAE EAE + ++ L Q
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1847
Score = 58.2 bits (139), Expect = 8e-08
Identities = 42/169 (24%), Positives = 82/169 (48%), Gaps = 26/169 (15%)
Query: 124 KILVHSL-----FNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 172
++LVH L ++ I I N V M M + + K Y FT I+ ES+
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626
Query: 173 KILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 221
K++A GF F +D WN LD ++ + + ++ V+A +R R+
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
Query: 222 LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
R LK + + G++ ++ ++Q++ ++ ++ +L + +FA +G++LF
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731
Score = 55.8 bits (133), Expect = 4e-07
Identities = 47/163 (28%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 1533 FDISIMILICLNMVTMMV----ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
F+ M++I LN VT+ + E + IL + F E V+K+++L +
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
Y WN DF +VI ++ L + F +R R+ R LR I
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195
Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A + R
Sbjct: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238
Score = 32.3 bits (72), Expect = 4.8
Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)
Query: 1696 NFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFF 1755
NF+ G + I +FQ+ T GW ++ ++++ + +
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374
Query: 1756 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1792
F+ II+ ++N+ + VI FS + ++ + E
Sbjct: 375 FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 333 bits (854), Expect = 1e-90
Identities = 200/612 (32%), Positives = 341/612 (55%), Gaps = 46/612 (7%)
Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
R C++I+ H F+ ++ +I L+ +A E I+ + L ++ +FT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1258 LLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1310
+K VA G+ Q Y ++W LD L+V +S++ + + + G LG ++ LR LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF+ C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1441
Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
GE D + N S+C + + RW K NFDN+G +SL +A+ GW+DIMY
Sbjct: 1442 QGE--DTRNITNKSDC-----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1494
Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
+D+ V+ QP N +M LYF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1495 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1553
Query: 1491 TEEQKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTKQVFDISIMILICLN 1544
E+K+ KK SK+ Q KP ++F+ +V T D+ I +I LN
Sbjct: 1554 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1613
Query: 1545 MVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVI 1603
+VTM +E Q Q + L N +F V+F E V KL++ + +F WN D +V+
Sbjct: 1614 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1673
Query: 1604 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661
LSI+G+ L E+ ++PT+ R++R+ RI R+L+L+K A G+R LL +M +LP +
Sbjct: 1674 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1733
Query: 1662 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1716
N+GLL L+ FI+A G+ F ++ + G+ F FG + + LF+++T W
Sbjct: 1734 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1793
Query: 1717 DGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1776
+G++ L DCD + C N + +FVS+++ + V+VN+ IAV++
Sbjct: 1794 NGIMKDTLR----DCDQE---------STCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1840
Query: 1777 ENFSVATEESAE 1788
++ + +E+ E
Sbjct: 1841 KHLEESNKEAKE 1852
Score = 139 bits (351), Expect = 2e-32
Identities = 81/269 (30%), Positives = 148/269 (55%), Gaps = 14/269 (5%)
Query: 745 WLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTA 804
W + +V + I I I++NTL M +E++ E+ ++ L + N+VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 805 EMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSW 864
EM LK++ P+ Y + +NIFDG IV +S+ E+ GLSVLR+FRL+RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 865 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCE---LP 921
P L + ++ ++ + ++L + +FIF+++GM LFG CK +++ + LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901
Query: 922 -RWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFL 979
R + + + VF++L E W + +++ M L F+ +M GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAAL-YFIALMTFGNYVLFNLLV 960
Query: 980 ALLLSSFSSDNLAATDD-DNEMNNLQIAV 1007
A+L+ F ++ ++ +D +++ +Q+ V
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPV 989
Score = 122 bits (307), Expect = 3e-27
Identities = 96/355 (27%), Positives = 169/355 (47%), Gaps = 36/355 (10%)
Query: 119 RKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 168
R ++ + + F + M IL NCV + M P + + + +
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
Query: 169 ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 226
E ++K++A G + +L D WN LDF ++ + +DL NVS A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
Query: 227 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNS 286
I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LRN+C + P+N
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247
Query: 287 SFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIED-----KSHFYFLEGQNDALLCG-- 339
S +++ L+ T N S F + E+ +S CG
Sbjct: 248 SLPLSV------DLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLD 301
Query: 340 ----NSSDAGQC---PEGYICVKAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQ 391
NSS C + Y AG NP G +FD +A++++F+++T + W ++
Sbjct: 302 YEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMY 361
Query: 392 LTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 446
+ A I+F+L+I +GSF++INL L V+A + E Q + ++ F
Sbjct: 362 FVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
Score = 112 bits (281), Expect = 3e-24
Identities = 82/279 (29%), Positives = 136/279 (48%), Gaps = 28/279 (10%)
Query: 742 CKPWL----KVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
CKP+ + + LV+ + ++DL IT I LN + MAMEHY + L + N +
Sbjct: 1579 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1638
Query: 798 FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG----------LS 847
FT IF E K++A +FQ+ WN D IV LS+M + L +E +
Sbjct: 1639 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1698
Query: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 907
++R R+ RV KL K + L+ + ++ +GNL L+ ++ FIFA +G++LFG
Sbjct: 1699 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1755
Query: 908 KECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-TMCLTV- 962
+ C ++ CE H +F +FL +FRV G+ W M D + Q + C
Sbjct: 1756 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1814
Query: 963 -----FMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDD 996
F+ ++ V++N+ +A+L+ N A ++
Sbjct: 1815 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1853
Score = 111 bits (277), Expect = 8e-24
Identities = 145/686 (21%), Positives = 284/686 (41%), Gaps = 115/686 (16%)
Query: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
+FD+ WA +++F+++TQ+ W + + + ++F+ ++ G++ L NL++A++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSE 485
++ + E +++++A Q QL ++Q A S DF G
Sbjct: 965 EGFQAE-----EISKREDASGQLSCIQLPV---DSQGGDANKSESEPDFFSPSLDGDGDR 1016
Query: 486 SSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSR 545
+A +S EL+ + + + +++ R S GS
Sbjct: 1017 KKCLAL-VSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSA 1075
Query: 546 ---LTYEKRF-----SSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDI---------- 587
+E + SSPH + S ++ RR+SR SL GRA +
Sbjct: 1076 EPGAAHEMKSPPSARSSPHSPWSA--ASSWTSRRSSRNSL----GRAPSLKRRSPSGERR 1129
Query: 588 ----GSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGK 643
G + D+E S+ E+ S S HRH ++ + +++S LP
Sbjct: 1130 SLLSGEGQESQDEEESSEEERASPAGS---DHRH----RGSLEREAKSSFDLPDTLQVPG 1182
Query: 644 MHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQR 703
+H G S + +++G+L R R + D +D + +
Sbjct: 1183 LHRTASGRGSASEHQDCNGKSASGRLA----------RALRPDDPPLDGDDADDEGNLSK 1232
Query: 704 AMSIASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWL-----KVKHLVNLVVMD 758
+ + + R + P C CL D ++ + + L + ++
Sbjct: 1233 GERVRAWI----------RARLPAC-------CLERDSWSAYIFPPQSRFRLLCHRIITH 1275
Query: 759 PFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTGIFTAEMFLKIIAMDP 815
D + + I LN + +AME P + S+ L++ N +FT +F AEM +K++A+
Sbjct: 1276 KMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGW 1334
Query: 816 YY----YFQEGWNIFDGFIVSLSLMELGLANVEG--------LSVLRSFRLLRVFKLAKS 863
+ Y + WN+ DG +V +S++++ ++ V L VLR R LR ++
Sbjct: 1335 CFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISR 1394
Query: 864 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC----VCKISN--D 917
L ++++ + +S+ +GN+ ++ IF ++G+QLF + C I+N D
Sbjct: 1395 AQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSD 1454
Query: 918 CELP--RWHMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVAG---------QTMCL 960
C RW H D L+ VL + W++ M+D ++ G L
Sbjct: 1455 CAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWML 1514
Query: 961 TVFMMVMVIGNLVVLNLFLALLLSSF 986
F+ ++I VLN+F+ +++ +F
Sbjct: 1515 LYFISFLLIVAFFVLNMFVGVVVENF 1540
Score = 107 bits (266), Expect = 2e-22
Identities = 87/393 (22%), Positives = 159/393 (40%), Gaps = 89/393 (22%)
Query: 110 YILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 161
YI P + R L +I+ H +F+ +++ I NC+ + M P + E Y
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Query: 162 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 212
FT ++ E +K++A G+C + +LR WN LD ++ + + V LG
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
Query: 213 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
+ LR R LR L+ IS GLK +V L+ S+K + +++++ +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Query: 273 NLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQ 332
F+ +G+
Sbjct: 1437 K----------------------------------------------------FFVCQGE 1444
Query: 333 NDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQL 392
D N SD + ++ K Y + D A +SLF L ++D W ++
Sbjct: 1445 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1494
Query: 393 TLRAAG----------KTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK 442
L A G +++F+ + + +F+++N+ + VV + + Q EE ++
Sbjct: 1495 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1554
Query: 443 EAEFQQMLEQLKKQQEEAQAAAAAASAESRDFS 475
E + + K++ +E Q A A D+S
Sbjct: 1555 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1587
Score = 94.0 bits (232), Expect = 1e-18
Identities = 59/171 (34%), Positives = 95/171 (55%), Gaps = 13/171 (7%)
Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1253
R C + V + WFE + +ILL+ L EDI + ++ + + + D +F + F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128
Query: 1254 ILEMLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1310
+EM++K VA +G + Y + W LDF IV ++ + + S ++RT+R
Sbjct: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS----FSAVRTVRV 184
Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
LRPLRA++R MR++V LL +P + NVLL+C + IF I+GV L+AG
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 91.3 bits (225), Expect = 9e-18
Identities = 68/287 (23%), Positives = 132/287 (45%), Gaps = 44/287 (15%)
Query: 1194 WWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1253
W + T KIV+ +F I+ IL+++ ++ E Y EQ + + LE ++ VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
Query: 1254 ILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
LEMLLK + YG Y N + D +IV +S+ + + G + LRT R +R
Sbjct: 787 ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRV 841
Query: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGE 1373
L+ + ++ + L+ + ++ ++ ++F IFSI+G++LF KF
Sbjct: 842 LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---------- 891
Query: 1374 MFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVD 1433
S + + NFD++ +++ Q+ T + W ++Y +
Sbjct: 892 -----------------ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMA 934
Query: 1434 SRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1480
S + + LYF+ + FG++ NL + ++++ F ++
Sbjct: 935 S----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 88.6 bits (218), Expect = 6e-17
Identities = 73/272 (26%), Positives = 124/272 (45%), Gaps = 40/272 (14%)
Query: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISL-R 1586
V + F IMI I +N ++M +E +Q +E+TN L N+VF LF E +LKL+
Sbjct: 740 VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799
Query: 1587 YYYFTIGWNIFDFVVVILS---IVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1643
+ Y +NIFD V+V++S IVG L V+R R+ R+L+L++
Sbjct: 800 FGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRFL 848
Query: 1644 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKREVGIDDMFNFET 1699
++ L LM ++ + +LL L +FI++I GM FA + + D NF++
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
Query: 1700 FGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSY 1759
+++ +FQI T W+ +L G S +F++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIAL 947
Query: 1760 IIISFLVVVNMYIAVILENFSVATEESAEPLS 1791
+ V+ N+ +A+++E F E S
Sbjct: 948 MTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979
Score = 71.2 bits (173), Expect = 9e-12
Identities = 34/104 (32%), Positives = 61/104 (58%), Gaps = 13/104 (12%)
Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
+NFDN+G ++++ QV T +GW+DIMY +D+ + Y ++YF++ II GSF
Sbjct: 335 INFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSF 384
Query: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
F +NL + VI F++ K++ + M E++ ++ + L S
Sbjct: 385 FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
Score = 66.6 bits (161), Expect = 2e-10
Identities = 44/155 (28%), Positives = 83/155 (53%), Gaps = 13/155 (8%)
Query: 124 KILVHSLFNMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 177
KI+ F IM IL N + M + P + T +E + FT ++ E L+K+L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
Query: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 235
G F ++++P+N D ++ + V E V G +S LRTFR++R LK + +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
Query: 236 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
+ L++++ ++ +L + + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 63.9 bits (154), Expect = 1e-09
Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 10/157 (6%)
Query: 756 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKII 811
V +P+ + + I+LN + + M E Q +L + F EM +K++
Sbjct: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
Query: 812 AMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 866
A+ + Y + WN D FIV ++E L L NV S +R+ R+LR + P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196
Query: 867 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
+ +L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 59.3 bits (142), Expect = 4e-08
Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)
Query: 346 QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 402
+C E + C GR + +F F AFL+LFR+ T D W + + TLR +
Sbjct: 1758 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1812
Query: 403 -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQ 456
I+FV + F L+N+++AV+ EE N+ EEAE EAE + ++ L Q
Sbjct: 1813 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1870
Score = 58.2 bits (139), Expect = 8e-08
Identities = 42/169 (24%), Positives = 82/169 (48%), Gaps = 26/169 (15%)
Query: 124 KILVHSL-----FNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 172
++LVH L ++ I I N V M M + + K Y FT I+ ES+
Sbjct: 1590 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1649
Query: 173 KILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 221
K++A GF F +D WN LD ++ + + ++ V+A +R R+
Sbjct: 1650 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1705
Query: 222 LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
R LK + + G++ ++ ++Q++ ++ ++ +L + +FA +G++LF
Sbjct: 1706 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1754
Score = 55.8 bits (133), Expect = 4e-07
Identities = 47/163 (28%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 1533 FDISIMILICLNMVTMMV----ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
F+ M++I LN VT+ + E + IL + F E V+K+++L +
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
Y WN DF +VI ++ L + F +R R+ R LR I
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195
Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A + R
Sbjct: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238
Score = 32.3 bits (72), Expect = 4.8
Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)
Query: 1696 NFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFF 1755
NF+ G + I +FQ+ T GW ++ ++++ + +
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374
Query: 1756 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1792
F+ II+ ++N+ + VI FS + ++ + E
Sbjct: 375 FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 333 bits (854), Expect = 1e-90
Identities = 200/612 (32%), Positives = 341/612 (55%), Gaps = 46/612 (7%)
Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
R C++I+ H F+ ++ +I L+ +A E I+ + L ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1258 LLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1310
+K VA G+ Q Y ++W LD L+V +S++ + + + G LG ++ LR LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF+ C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1418
Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
GE D + N S+C + + RW K NFDN+G +SL +A+ GW+DIMY
Sbjct: 1419 QGE--DTRNITNKSDC-----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1471
Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
+D+ V+ QP N +M LYF+ F++ +FF LN+F+GV+++NF++ ++ ++
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1530
Query: 1491 TEEQKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTKQVFDISIMILICLN 1544
E+K+ KK SK+ Q KP ++F+ +V T D+ I +I LN
Sbjct: 1531 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1590
Query: 1545 MVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVI 1603
+VTM +E Q Q + L N +F V+F E V KL++ + +F WN D +V+
Sbjct: 1591 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1650
Query: 1604 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661
LSI+G+ L E+ ++PT+ R++R+ RI R+L+L+K A G+R LL +M +LP +
Sbjct: 1651 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1710
Query: 1662 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1716
N+GLL L+ FI+A G+ F ++ + G+ F FG + + LF+++T W
Sbjct: 1711 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1770
Query: 1717 DGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1776
+G++ L DCD + C N + +FVS+++ + V+VN+ IAV++
Sbjct: 1771 NGIMKDTLR----DCDQE---------STCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817
Query: 1777 ENFSVATEESAE 1788
++ + +E+ E
Sbjct: 1818 KHLEESNKEAKE 1829
Score = 135 bits (340), Expect = 4e-31
Identities = 78/250 (31%), Positives = 137/250 (54%), Gaps = 13/250 (5%)
Query: 745 WLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTA 804
W + +V + I I I++NTL M +E++ E+ ++ L + N+VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 805 EMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSW 864
EM LK++ P+ Y + +NIFDG IV +S+ E+ GLSVLR+FRL+RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 865 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCE---LP 921
P L + ++ ++ + ++L + +FIF+++GM LFG CK +++ + LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901
Query: 922 -RWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFL 979
R + + + VF++L E W + +++ M L F+ +M GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAAL-YFIALMTFGNYVLFNLLV 960
Query: 980 ALLLSSFSSD 989
A+L+ F ++
Sbjct: 961 AILVEGFQAE 970
Score = 122 bits (307), Expect = 3e-27
Identities = 96/355 (27%), Positives = 169/355 (47%), Gaps = 36/355 (10%)
Query: 119 RKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 168
R ++ + + F + M IL NCV + M P + + + +
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
Query: 169 ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 226
E ++K++A G + +L D WN LDF ++ + +DL NVS A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
Query: 227 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNS 286
I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LRN+C + P+N
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247
Query: 287 SFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIED-----KSHFYFLEGQNDALLCG-- 339
S +++ L+ T N S F + E+ +S CG
Sbjct: 248 SLPLSV------DLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLD 301
Query: 340 ----NSSDAGQC---PEGYICVKAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQ 391
NSS C + Y AG NP G +FD +A++++F+++T + W ++
Sbjct: 302 YEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMY 361
Query: 392 LTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 446
+ A I+F+L+I +GSF++INL L V+A + E Q + ++ F
Sbjct: 362 FVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
Score = 114 bits (286), Expect = 7e-25
Identities = 137/678 (20%), Positives = 276/678 (40%), Gaps = 122/678 (17%)
Query: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
+FD+ WA +++F+++TQ+ W + + + ++F+ ++ G++ L NL++A++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSE 485
++ + +A + E+E L + + A + E + + +
Sbjct: 965 EGFQAEG-----DANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1019
Query: 486 SSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSR 545
+++ L + L ++ S + + +S S R
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR------------ 1067
Query: 546 LTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDI--------------GSEN 591
SSPH + S ++ RR+SR SL GRA + G
Sbjct: 1068 -------SSPHSPWSA--ASSWTSRRSSRNSL----GRAPSLKRRSPSGERRSLLSGEGQ 1114
Query: 592 DFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCN 651
+ D+E S+ E+ S S HRH ++ + +++S LP +H
Sbjct: 1115 ESQDEEESSEEERASPAGS---DHRH----RGSLEREAKSSFDLPDTLQVPGLHRTASGR 1167
Query: 652 GVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASIL 711
G S + +++G+L R R + D +D + + + + +
Sbjct: 1168 GSASEHQDCNGKSASGRLA----------RALRPDDPPLDGDDADDEGNLSKGERVRAWI 1217
Query: 712 TNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWL-----KVKHLVNLVVMDPFVDLAIT 766
R + P C CL D ++ + + L + ++ D +
Sbjct: 1218 ----------RARLPAC-------CLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260
Query: 767 ICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTGIFTAEMFLKIIAMDPYY----YF 819
+ I LN + +AME P + S+ L++ N +FT +F AEM +K++A+ + Y
Sbjct: 1261 VIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYL 1319
Query: 820 QEGWNIFDGFIVSLSLMELGLANVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLI 871
+ WN+ DG +V +S++++ ++ V L VLR R LR ++ L +++
Sbjct: 1320 RSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVV 1379
Query: 872 KIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC----VCKISN--DCELP--RW 923
+ + +S+ +GN+ ++ IF ++G+QLF + C I+N DC RW
Sbjct: 1380 ETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRW 1439
Query: 924 HMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVAG---------QTMCLTVFMMVMV 968
H D L+ VL + W++ M+D ++ G L F+ ++
Sbjct: 1440 VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL 1499
Query: 969 IGNLVVLNLFLALLLSSF 986
I VLN+F+ +++ +F
Sbjct: 1500 IVAFFVLNMFVGVVVENF 1517
Score = 112 bits (281), Expect = 3e-24
Identities = 82/279 (29%), Positives = 136/279 (48%), Gaps = 28/279 (10%)
Query: 742 CKPWL----KVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
CKP+ + + LV+ + ++DL IT I LN + MAMEHY + L + N +
Sbjct: 1556 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615
Query: 798 FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG----------LS 847
FT IF E K++A +FQ+ WN D IV LS+M + L +E +
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675
Query: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 907
++R R+ RV KL K + L+ + ++ +GNL L+ ++ FIFA +G++LFG
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1732
Query: 908 KECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-TMCLTV- 962
+ C ++ CE H +F +FL +FRV G+ W M D + Q + C
Sbjct: 1733 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1791
Query: 963 -----FMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDD 996
F+ ++ V++N+ +A+L+ N A ++
Sbjct: 1792 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830
Score = 107 bits (266), Expect = 2e-22
Identities = 87/393 (22%), Positives = 159/393 (40%), Gaps = 89/393 (22%)
Query: 110 YILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 161
YI P + R L +I+ H +F+ +++ I NC+ + M P + E Y
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Query: 162 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 212
FT ++ E +K++A G+C + +LR WN LD ++ + + V LG
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
Query: 213 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
+ LR R LR L+ IS GLK +V L+ S+K + +++++ +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Query: 273 NLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQ 332
F+ +G+
Sbjct: 1414 K----------------------------------------------------FFVCQGE 1421
Query: 333 NDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQL 392
D N SD + ++ K Y + D A +SLF L ++D W ++
Sbjct: 1422 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1471
Query: 393 TLRAAG----------KTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK 442
L A G +++F+ + + +F+++N+ + VV + + Q EE ++
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Query: 443 EAEFQQMLEQLKKQQEEAQAAAAAASAESRDFS 475
E + + K++ +E Q A A D+S
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1564
Score = 94.0 bits (232), Expect = 1e-18
Identities = 59/171 (34%), Positives = 95/171 (55%), Gaps = 13/171 (7%)
Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1253
R C + V + WFE + +ILL+ L EDI + ++ + + + D +F + F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128
Query: 1254 ILEMLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1310
+EM++K VA +G + Y + W LDF IV ++ + + S ++RT+R
Sbjct: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS----FSAVRTVRV 184
Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
LRPLRA++R MR++V LL +P + NVLL+C + IF I+GV L+AG
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 91.7 bits (226), Expect = 7e-18
Identities = 84/315 (26%), Positives = 145/315 (46%), Gaps = 47/315 (14%)
Query: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISL-R 1586
V + F IMI I +N ++M +E +Q +E+TN L N+VF LF E +LKL+
Sbjct: 740 VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799
Query: 1587 YYYFTIGWNIFDFVVVILS---IVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1643
+ Y +NIFD V+V++S IVG L V+R R+ R+L+L++
Sbjct: 800 FGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRFL 848
Query: 1644 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKREVGIDDMFNFET 1699
++ L LM ++ + +LL L +FI++I GM FA + + D NF++
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
Query: 1700 FGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSY 1759
+++ +FQI T W+ +L G S +F++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIAL 947
Query: 1760 IIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLS 1819
+ V+ N+ +A+++E F A ++ + SE D F+ D D + + L
Sbjct: 948 MTFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPD---FFSPSLDGDGDRKKCLALVSLG 1003
Query: 1820 DFAD---ALDPPLLI 1831
+ + +L PPL+I
Sbjct: 1004 EHPELRKSLLPPLII 1018
Score = 90.9 bits (224), Expect = 1e-17
Identities = 68/286 (23%), Positives = 131/286 (45%), Gaps = 44/286 (15%)
Query: 1194 WWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1253
W + T KIV+ +F I+ IL+++ ++ E Y EQ + + LE ++ VFT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
Query: 1254 ILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
LEMLLK + YG Y N + D +IV +S+ + + G + LRT R +R
Sbjct: 787 ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRV 841
Query: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGE 1373
L+ + ++ + L+ + ++ ++ ++F IFSI+G++LF KF
Sbjct: 842 LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---------- 891
Query: 1374 MFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVD 1433
S + + NFD++ +++ Q+ T + W ++Y +
Sbjct: 892 -----------------ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMA 934
Query: 1434 SRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1479
S + + LYF+ + FG++ NL + ++++ F +
Sbjct: 935 S----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 71.2 bits (173), Expect = 9e-12
Identities = 34/104 (32%), Positives = 61/104 (58%), Gaps = 13/104 (12%)
Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
+NFDN+G ++++ QV T +GW+DIMY +D+ + Y ++YF++ II GSF
Sbjct: 335 INFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSF 384
Query: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
F +NL + VI F++ K++ + M E++ ++ + L S
Sbjct: 385 FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
Score = 66.6 bits (161), Expect = 2e-10
Identities = 44/155 (28%), Positives = 83/155 (53%), Gaps = 13/155 (8%)
Query: 124 KILVHSLFNMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 177
KI+ F IM IL N + M + P + T +E + FT ++ E L+K+L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
Query: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 235
G F ++++P+N D ++ + V E V G +S LRTFR++R LK + +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
Query: 236 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
+ L++++ ++ +L + + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 63.9 bits (154), Expect = 1e-09
Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 10/157 (6%)
Query: 756 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKII 811
V +P+ + + I+LN + + M E Q +L + F EM +K++
Sbjct: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
Query: 812 AMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 866
A+ + Y + WN D FIV ++E L L NV S +R+ R+LR + P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196
Query: 867 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
+ +L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 59.3 bits (142), Expect = 4e-08
Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)
Query: 346 QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 402
+C E + C GR + +F F AFL+LFR+ T D W + + TLR +
Sbjct: 1735 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789
Query: 403 -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQ 456
I+FV + F L+N+++AV+ EE N+ EEAE EAE + ++ L Q
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1847
Score = 58.2 bits (139), Expect = 8e-08
Identities = 42/169 (24%), Positives = 82/169 (48%), Gaps = 26/169 (15%)
Query: 124 KILVHSL-----FNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 172
++LVH L ++ I I N V M M + + K Y FT I+ ES+
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626
Query: 173 KILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 221
K++A GF F +D WN LD ++ + + ++ V+A +R R+
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
Query: 222 LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
R LK + + G++ ++ ++Q++ ++ ++ +L + +FA +G++LF
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731
Score = 55.8 bits (133), Expect = 4e-07
Identities = 47/163 (28%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 1533 FDISIMILICLNMVTMMV----ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
F+ M++I LN VT+ + E + IL + F E V+K+++L +
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
Y WN DF +VI ++ L + F +R R+ R LR I
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195
Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A + R
Sbjct: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238
Score = 32.3 bits (72), Expect = 4.8
Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)
Query: 1696 NFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFF 1755
NF+ G + I +FQ+ T GW ++ ++++ + +
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374
Query: 1756 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1792
F+ II+ ++N+ + VI FS + ++ + E
Sbjct: 375 FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,893,396
Number of Sequences: 37866
Number of extensions: 3179586
Number of successful extensions: 25787
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 305
Number of HSP's that attempted gapping in prelim test: 17655
Number of HSP's gapped (non-prelim): 4777
length of query: 2005
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1888
effective length of database: 13,817,196
effective search space: 26086866048
effective search space used: 26086866048
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.