Search of human proteins with 92859670

Search of human proteins with 92859670

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|92859670 solute carrier family 6 (neurotransmitter
transporter, glycine), member 5 [Homo sapiens]
         (797 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|92859670 solute carrier family 6 (neurotransmitter transporte...  1635   0.0  
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   644   0.0  
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...   635   0.0  
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...   633   0.0  
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...   632   0.0  
gi|134304856 solute carrier family 6, member 7 [Homo sapiens]         615   e-176
gi|188528618 solute carrier family 6 (neurotransmitter transport...   559   e-159
gi|21361581 solute carrier family 6 (neurotransmitter transporte...   528   e-150
gi|171184408 solute carrier family 6 (neurotransmitter transport...   526   e-149
gi|171184406 solute carrier family 6 (neurotransmitter transport...   526   e-149
gi|171184404 solute carrier family 6 (neurotransmitter transport...   526   e-149
gi|4557046 solute carrier family 6 member 2 [Homo sapiens]            523   e-148
gi|197276623 solute carrier family 6 (neurotransmitter transport...   522   e-148
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   522   e-148
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   520   e-147
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   517   e-146
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...   514   e-145
gi|4507043 solute carrier family 6 member 4 [Homo sapiens]            501   e-142
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...   497   e-140
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...   417   e-116
gi|51468073 solute carrier family 6, member 19 [Homo sapiens]         401   e-111
gi|194018524 solute carrier family 6, member 18 [Homo sapiens]        390   e-108
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...   365   e-101
gi|58219014 solute carrier family 6, member 17 [Homo sapiens]         313   3e-85
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...   302   9e-82
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...   273   6e-73
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         228   2e-59
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...   201   3e-51
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   169   9e-42
gi|197276625 solute carrier family 6 (neurotransmitter transport...   167   4e-41

>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score = 1635 bits (4235), Expect = 0.0
 Identities = 797/797 (100%), Positives = 797/797 (100%)

Query: 1   MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ 60
           MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ
Sbjct: 1   MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ 60

Query: 61  TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC 120
           TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC
Sbjct: 61  TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC 120

Query: 121 KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ 180
           KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ
Sbjct: 121 KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ 180

Query: 181 EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA 240
           EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA
Sbjct: 181 EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA 240

Query: 241 GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA 300
           GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
Sbjct: 241 GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA 300

Query: 301 SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT 360
           SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT
Sbjct: 301 SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT 360

Query: 361 SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK 420
           SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK
Sbjct: 361 SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK 420

Query: 421 VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA 480
           VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA
Sbjct: 421 VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA 480

Query: 481 AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD 540
           AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD
Sbjct: 481 AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD 540

Query: 541 QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT 600
           QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT
Sbjct: 541 QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT 600

Query: 601 HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR 660
           HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR
Sbjct: 601 HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR 660

Query: 661 FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL 720
           FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL
Sbjct: 661 FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL 720

Query: 721 MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS 780
           MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS
Sbjct: 721 MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS 780

Query: 781 SLGLKLPVKDLELGTQC 797
           SLGLKLPVKDLELGTQC
Sbjct: 781 SLGLKLPVKDLELGTQC 797


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  644 bits (1660), Expect = 0.0
 Identities = 322/603 (53%), Positives = 415/603 (68%), Gaps = 17/603 (2%)

Query: 184 QGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLP 243
           + DEN+ RGNWS K D++LSM+GYAVGLGNVWRFPYL + NGGGAFLIPY +MLALAGLP
Sbjct: 29  ENDENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLP 88

Query: 244 IFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFV 303
           +FFLE SLGQFAS GPVSVW+ +P  QG GI M++IS+ + IYYNVII Y+L+Y+FASF 
Sbjct: 89  LFFLECSLGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQ 148

Query: 304 SVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPK-----IQIKNSTFCMTAYPNVTMVN 358
           S LPW +C++ W+   C      ++  C +S   K     IQ+  S   +    N T +N
Sbjct: 149 SELPWKNCSS-WSDKNCSRSP--IVTHCNVSTVNKGIQEIIQMNKSWVDIN---NFTCIN 202

Query: 359 FTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTS 418
             S+  +     SE+Y+    L+ S+G+   G I W LALCL LAW+IV A+L KGIK+S
Sbjct: 203 -GSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSS 261

Query: 419 GKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPK--WEKLTDATVWKDAATQIFF 476
           GKVVYFTA FPYVVL+ILL+RG TL GA  GI Y+I  +  + KL +A VWKDAATQIF+
Sbjct: 262 GKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFY 321

Query: 477 SLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIE 536
           SLS AWGGL+ LSSYNKF NNC+ D ++V  TN  TS+FAGF IFS++G MA+     + 
Sbjct: 322 SLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVS 381

Query: 537 NVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPK 596
            V   G  +AF+ YPEAL +LP  PFW+I+FF MLLTLGLD+ FA+IETI T+I D FPK
Sbjct: 382 QVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPK 441

Query: 597 YLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVY 656
            ++  +   TLGCC+  F++G   +TQ GIY   L+D + A + ++I AI ELVGI ++Y
Sbjct: 442 VMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIY 501

Query: 657 GLQRFCEDIEMMIGFQPNIF---WKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNW 713
           G  RF ED EMMIG +  IF   W+ CW  +TP +L  I  +S  Q+    YG+  YP+W
Sbjct: 502 GGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNYGAIPYPDW 561

Query: 714 SMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNM 773
            + LGW M+   +IWIPIM +IK+  A G   +RL   C P  +WGP+L QHRGERYK+M
Sbjct: 562 GVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCCRPASNWGPYLEQHRGERYKDM 621

Query: 774 IDP 776
           +DP
Sbjct: 622 VDP 624


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score =  635 bits (1637), Expect = 0.0
 Identities = 301/616 (48%), Positives = 423/616 (68%), Gaps = 25/616 (4%)

Query: 165 GITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQN 224
           G   +L G+V + AT+ D+    N  RGNW ++++F+L+ VGYAVGLGNVWRFPYL ++N
Sbjct: 5   GAKGMLNGAVPSEATKRDQ----NLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRN 60

Query: 225 GGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIA 284
           GGGAF+ PY +ML   G+P+FF+E+S GQFASQG + VW+  P  +G G  M+++S  I 
Sbjct: 61  GGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIG 120

Query: 285 IYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNS 344
           IYYNV+IC   +Y F+S   VLPW  CNNPWNT +C      +LD+  +++  +      
Sbjct: 121 IYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAG----VLDASNLTNGSR------ 170

Query: 345 TFCMTAYPNVTMVNFTSQANKTF--VSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFL 402
                  P     N +   N +    S SEEY++ +VLK+S  I   GE+R PL  CL +
Sbjct: 171 -------PAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGV 223

Query: 403 AWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLT 462
           +W++V+  L +G+K+SGKVVYFTATFPYVVL IL +RGVTL GA  GI Y++TP+W+K+ 
Sbjct: 224 SWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKIL 283

Query: 463 DATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFS 522
           +A VW DAA+QIF+SL  AWGGLIT++SYNKFHNNCYRD++I++ TN ATS++AGFVIFS
Sbjct: 284 EAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFS 343

Query: 523 VIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFAT 582
           ++GFMAN   V++  VAD GPG+AFV YPEALT LP+SP W+++FF ML+ LGL T F  
Sbjct: 344 ILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCL 403

Query: 583 IETIVTSISDEF-PKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYAL 641
           +ET+VT+I DE   +++   K   TLG  +  F++G P+ +Q GIY   L+D YAAS++L
Sbjct: 404 LETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSL 463

Query: 642 VIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWE 701
           V+I+    V I Y+YG + + +DI+MM+GF P +F+++CW FV+P I+ FIL F+  Q++
Sbjct: 464 VVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQ 523

Query: 702 PMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPG-RFIERLKLVCSPQPDWGP 760
           P+TY  Y+YP W++ +G+LM   SV+ IP+  + ++    G   ++RLK    P  DWGP
Sbjct: 524 PITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGP 583

Query: 761 FLAQHRGERYKNMIDP 776
            L +HR  RY   I P
Sbjct: 584 ALLEHRTGRYAPTIAP 599


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  633 bits (1632), Expect = 0.0
 Identities = 300/621 (48%), Positives = 424/621 (68%), Gaps = 25/621 (4%)

Query: 160 VLATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPY 219
           ++A   +     G+V + AT+ D+    N  RGNW ++++F+L+ VGYAVGLGNVWRFPY
Sbjct: 73  LMAQHSLAMAQNGAVPSEATKRDQ----NLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPY 128

Query: 220 LAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLII 279
           L ++NGGGAF+ PY +ML   G+P+FF+E+S GQFASQG + VW+  P  +G G  M+++
Sbjct: 129 LCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVV 188

Query: 280 SVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKI 339
           S  I IYYNV+IC   +Y F+S   VLPW  CNNPWNT +C      +LD+  +++  + 
Sbjct: 189 STYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAG----VLDASNLTNGSR- 243

Query: 340 QIKNSTFCMTAYPNVTMVNFTSQANKTF--VSGSEEYFKYFVLKISAGIEYPGEIRWPLA 397
                       P     N +   N +    S SEEY++ +VLK+S  I   GE+R PL 
Sbjct: 244 ------------PAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLL 291

Query: 398 LCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPK 457
            CL ++W++V+  L +G+K+SGKVVYFTATFPYVVL IL +RGVTL GA  GI Y++TP+
Sbjct: 292 GCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQ 351

Query: 458 WEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAG 517
           W+K+ +A VW DAA+QIF+SL  AWGGLIT++SYNKFHNNCYRD++I++ TN ATS++AG
Sbjct: 352 WDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAG 411

Query: 518 FVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLD 577
           FVIFS++GFMAN   V++  VAD GPG+AFV YPEALT LP+SP W+++FF ML+ LGL 
Sbjct: 412 FVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLG 471

Query: 578 TMFATIETIVTSISDEF-PKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYA 636
           T F  +ET+VT+I DE   +++   K   TLG  +  F++G P+ +Q GIY   L+D YA
Sbjct: 472 TQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYA 531

Query: 637 ASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFS 696
           AS++LV+I+    V I Y+YG + + +DI+MM+GF P +F+++CW FV+P I+ FIL F+
Sbjct: 532 ASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFT 591

Query: 697 FYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPG-RFIERLKLVCSPQ 755
             Q++P+TY  Y+YP W++ +G+LM   SV+ IP+  + ++    G   ++RLK    P 
Sbjct: 592 VIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPS 651

Query: 756 PDWGPFLAQHRGERYKNMIDP 776
            DWGP L +HR  RY   I P
Sbjct: 652 RDWGPALLEHRTGRYAPTIAP 672


>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score =  632 bits (1630), Expect = 0.0
 Identities = 299/609 (49%), Positives = 420/609 (68%), Gaps = 25/609 (4%)

Query: 172 GSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLI 231
           G+V + AT+ D+    N  RGNW ++++F+L+ VGYAVGLGNVWRFPYL ++NGGGAF+ 
Sbjct: 31  GAVPSEATKRDQ----NLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMF 86

Query: 232 PYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVII 291
           PY +ML   G+P+FF+E+S GQFASQG + VW+  P  +G G  M+++S  I IYYNV+I
Sbjct: 87  PYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVI 146

Query: 292 CYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAY 351
           C   +Y F+S   VLPW  CNNPWNT +C      +LD+  +++  +             
Sbjct: 147 CIAFYYFFSSMTHVLPWAYCNNPWNTHDCAG----VLDASNLTNGSR------------- 189

Query: 352 PNVTMVNFTSQANKTF--VSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYA 409
           P     N +   N +    S SEEY++ +VLK+S  I   GE+R PL  CL ++W++V+ 
Sbjct: 190 PAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFL 249

Query: 410 SLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKD 469
            L +G+K+SGKVVYFTATFPYVVL IL +RGVTL GA  GI Y++TP+W+K+ +A VW D
Sbjct: 250 CLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGD 309

Query: 470 AATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAN 529
           AA+QIF+SL  AWGGLIT++SYNKFHNNCYRD++I++ TN ATS++AGFVIFS++GFMAN
Sbjct: 310 AASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMAN 369

Query: 530 ERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTS 589
              V++  VAD GPG+AFV YPEALT LP+SP W+++FF ML+ LGL T F  +ET+VT+
Sbjct: 370 HLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTA 429

Query: 590 ISDEF-PKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFE 648
           I DE   +++   K   TLG  +  F++G P+ +Q GIY   L+D YAAS++LV+I+   
Sbjct: 430 IVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIM 489

Query: 649 LVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSY 708
            V I Y+YG + + +DI+MM+GF P +F+++CW FV+P I+ FIL F+  Q++P+TY  Y
Sbjct: 490 CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHY 549

Query: 709 RYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPG-RFIERLKLVCSPQPDWGPFLAQHRG 767
           +YP W++ +G+LM   SV+ IP+  + ++    G   ++RLK    P  DWGP L +HR 
Sbjct: 550 QYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRT 609

Query: 768 ERYKNMIDP 776
            RY   I P
Sbjct: 610 GRYAPTIAP 618


>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score =  615 bits (1587), Expect = e-176
 Identities = 306/606 (50%), Positives = 408/606 (67%), Gaps = 31/606 (5%)

Query: 169 VLPGSVATVATQEDEQGDENKA--RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGG 226
           V P  + T + Q D   D + A  RGNW+ KLDF+LS +GY VGLGNVWRFPY A+ NGG
Sbjct: 13  VTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGG 72

Query: 227 GAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIY 286
           GAFL+PY +MLA+ G+P+FFLE+SLGQF+S GP++VWK  P  +G G AML+I  L+AIY
Sbjct: 73  GAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIY 132

Query: 287 YNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTF 346
           YN+II Y LFYLFAS  S LPW  C N WNT  C +             H   +  N   
Sbjct: 133 YNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLE-------------HRVSKDGNGAL 179

Query: 347 CMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKI--SAGIEYPGEIRWPLALCLFLAW 404
            +    N+T            VS SEEY+  +VL I  S GI  PGEIRW L LCL LAW
Sbjct: 180 PL----NLTCT----------VSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAW 225

Query: 405 VIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDA 464
           VIV+  + KG+K+SGKVVYFTATFPY++L++LL+RGVTLPGA  GI +++TP++  L  +
Sbjct: 226 VIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSS 285

Query: 465 TVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVI 524
            VW +AA QIF+SL   +GGL+T +SYN FH N YRDT IVT  N+ TSI AGF IFSV+
Sbjct: 286 KVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVL 345

Query: 525 GFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIE 584
           G+M+ E  V ++ VA  GPG+AFVVYP+A+T LPLSPFW+ +FF MLLTLGLD+ FA +E
Sbjct: 346 GYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLE 405

Query: 585 TIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVII 644
           TIVT+++DEFP YLR  K VF+   C+  ++MG  + T GG+Y   L+D Y+AS+ L+++
Sbjct: 406 TIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVV 465

Query: 645 AIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMT 704
            I   + ++ VYG+QRFC DI MM+GF+P ++++ CW F++P  L  ++ +S  +++P  
Sbjct: 466 VITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSE 525

Query: 705 YGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQ 764
           YGSYR+P W+ +LG LM   S + IP   ++ +    G   ERL+    P  DWGP L +
Sbjct: 526 YGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEE 585

Query: 765 HRGERY 770
           +R   Y
Sbjct: 586 NRTGMY 591


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  559 bits (1441), Expect = e-159
 Identities = 273/612 (44%), Positives = 388/612 (63%), Gaps = 51/612 (8%)

Query: 161 LATDGITSVLPGSVATVATQEDEQGDENKA--------------RGNWSSKLDFILSMVG 206
           +AT+G + V  G ++T  ++     D+ K               R  W  + DF++S VG
Sbjct: 1   MATNG-SKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVG 59

Query: 207 YAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAI 266
           YA+GLGNVWRFPYL  +NGGGAFLIPY + L  AG+P+F LE SLGQ+ S G + VWK  
Sbjct: 60  YAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLA 119

Query: 267 PALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKL 326
           P  +G G+A  ++S  + IYY VII + ++YL+ SF + LPW  C+NPWNT  C      
Sbjct: 120 PMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRC------ 173

Query: 327 LLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGI 386
                                   + N +MVN T+       S   E+++  + +++ G+
Sbjct: 174 ------------------------FSNYSMVNTTNMT-----SAVVEFWERNMHQMTDGL 204

Query: 387 EYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGA 446
           + PG+IRWPLA+ L +AW++VY  + KG+  +GKVVYF+AT+PY++L+IL  RGVTLPGA
Sbjct: 205 DKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGA 264

Query: 447 GAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVT 506
             GI ++ITP + KL+D+ VW DAATQIFFS     G LI L SYN FHNN YRD++IV 
Sbjct: 265 KEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVC 324

Query: 507 CTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAII 566
           C NS TS+FAGFVIFS++GFMA+  K +I +VA  GPG+AF+ YPEA+T+LP+SP WAI+
Sbjct: 325 CINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAIL 384

Query: 567 FFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGI 626
           FF MLL LG+D+ F T+E  +T++ DE+P+ LR  + +F    CI  +++G   ITQGGI
Sbjct: 385 FFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGI 444

Query: 627 YMFQLVDTYAAS-YALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVT 685
           Y+F+L D Y+AS  +L+ +  FE V IS+ YG+ RF ++I+ M+G +P I+WK+CW+F T
Sbjct: 445 YVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFT 504

Query: 686 PTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFI 745
           P I+  +  FS  Q  P+T G+Y +P W   +GWLM   S++ IP           G   
Sbjct: 505 PIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLK 564

Query: 746 ERLKLVCSPQPD 757
           +R++++  P  D
Sbjct: 565 QRIQVMVQPSED 576


>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score =  528 bits (1361), Expect = e-150
 Identities = 265/582 (45%), Positives = 368/582 (63%), Gaps = 35/582 (6%)

Query: 181 EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA 240
           E ++ D    RG+W++K++F+LS+ G  +GLGNVWRFPYL ++NGGGAF IPYL+ L   
Sbjct: 22  EKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTC 81

Query: 241 GLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLF 299
           G+P+F LE +LGQ+ SQG V+ W+ I P  +G G A  +I +L+ +YY +++ + LFYLF
Sbjct: 82  GIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLF 141

Query: 300 ASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNF 359
           +SF   LPWG C + WNT  C +                 Q  N +       N T  N 
Sbjct: 142 SSFTIDLPWGGCYHEWNTEHCME----------------FQKTNGSL------NGTSENA 179

Query: 360 TSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSG 419
           TS           E+++  VLKIS GI++ G +RW LALCL LAWVI Y  + KG+K++G
Sbjct: 180 TSPVI--------EFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTG 231

Query: 420 KVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLS 479
           KVVYFTATFPY++LV+LLIRGVTLPGA  GI +++ P   +L D  VW DA TQIFFS +
Sbjct: 232 KVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFA 291

Query: 480 AAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVA 539
              G L  L SYNK+HNNCYRD + +   NS TS  AGF IFS++GFM+ E+ V I  VA
Sbjct: 292 ICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVA 351

Query: 540 DQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLR 599
           + GPG+AF+ YP A+  LP SP WA  FF M++ LGLD+ F  +E++VT++ D +P   R
Sbjct: 352 ESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFR 411

Query: 600 --THKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYVY 656
               + V  LG  +  F++G  M+T+GG+Y+FQL D YAAS   L+ +AIFE + +++VY
Sbjct: 412 KKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVY 471

Query: 657 GLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYG-SYRYPNWSM 715
           G +RF ++IE MIG++P    K CW F+TP + T    FS  ++ P+TY   Y YP W  
Sbjct: 472 GAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGD 531

Query: 716 VLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPD 757
            LGWL+   S++ IP   + ++    G F ER++ +  P  D
Sbjct: 532 ALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCPAED 573


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  526 bits (1354), Expect = e-149
 Identities = 270/601 (44%), Positives = 381/601 (63%), Gaps = 41/601 (6%)

Query: 180 QEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLAL 239
           QEDE  D+ K RG W++K++F+LS+ G  +GLGNVWRFPYL ++NGGGAF IPY +   +
Sbjct: 27  QEDE--DQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFV 84

Query: 240 AGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYL 298
            G+P+FFLEV+LGQ+ SQG V+ W+ I P  QG G+A ++I   + +YY +I+ + LFYL
Sbjct: 85  CGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYL 144

Query: 299 FASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVN 358
           F+SF S LPW +CNN WNT  C D                    N +   T  P     N
Sbjct: 145 FSSFTSELPWTTCNNFWNTEHCTD------------------FLNHSGAGTVTP---FEN 183

Query: 359 FTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTS 418
           FTS           E+++  VL I++GI   G +RW LALCL LAWVI Y  + KG+K++
Sbjct: 184 FTSPV--------MEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKST 235

Query: 419 GKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSL 478
           GKVVYFTATFPY++LVILLIRGVTLPGA  GI Y++ P   +L D  VW DA TQIFFS 
Sbjct: 236 GKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSF 295

Query: 479 SAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENV 538
           +   G L  L SYNK+HNNCY+D + +   NSATS  AGFV+FS++GFM+ E+ V I  V
Sbjct: 296 AICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEV 355

Query: 539 ADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYL 598
           A+ GPG+AF+ +P+A+T +PLS  W+ +FF+ML+ LGLD+ F  +E +VT+  D FP+ L
Sbjct: 356 AESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQL 415

Query: 599 RT--HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYV 655
           R    + +  L   +  +++G  ++T+GG+Y+FQL D YA+S   L+ +++FE+V IS+V
Sbjct: 416 RKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWV 475

Query: 656 YGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGS-YRYPNWS 714
           YG  RF ++IE MIG++P    K+ W F+TP +      FS  ++ P+ Y + Y YP W 
Sbjct: 476 YGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWG 535

Query: 715 MVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCS-----PQPDWGPFLAQHRGER 769
             +GW +   S++ +P+  VI +    G F +RL+ + +     PQP   P L    G  
Sbjct: 536 YSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRN 595

Query: 770 Y 770
           +
Sbjct: 596 F 596


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  526 bits (1354), Expect = e-149
 Identities = 270/601 (44%), Positives = 381/601 (63%), Gaps = 41/601 (6%)

Query: 180 QEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLAL 239
           QEDE  D+ K RG W++K++F+LS+ G  +GLGNVWRFPYL ++NGGGAF IPY +   +
Sbjct: 27  QEDE--DQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFV 84

Query: 240 AGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYL 298
            G+P+FFLEV+LGQ+ SQG V+ W+ I P  QG G+A ++I   + +YY +I+ + LFYL
Sbjct: 85  CGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYL 144

Query: 299 FASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVN 358
           F+SF S LPW +CNN WNT  C D                    N +   T  P     N
Sbjct: 145 FSSFTSELPWTTCNNFWNTEHCTD------------------FLNHSGAGTVTP---FEN 183

Query: 359 FTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTS 418
           FTS           E+++  VL I++GI   G +RW LALCL LAWVI Y  + KG+K++
Sbjct: 184 FTSPV--------MEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKST 235

Query: 419 GKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSL 478
           GKVVYFTATFPY++LVILLIRGVTLPGA  GI Y++ P   +L D  VW DA TQIFFS 
Sbjct: 236 GKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSF 295

Query: 479 SAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENV 538
           +   G L  L SYNK+HNNCY+D + +   NSATS  AGFV+FS++GFM+ E+ V I  V
Sbjct: 296 AICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEV 355

Query: 539 ADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYL 598
           A+ GPG+AF+ +P+A+T +PLS  W+ +FF+ML+ LGLD+ F  +E +VT+  D FP+ L
Sbjct: 356 AESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQL 415

Query: 599 RT--HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYV 655
           R    + +  L   +  +++G  ++T+GG+Y+FQL D YA+S   L+ +++FE+V IS+V
Sbjct: 416 RKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWV 475

Query: 656 YGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGS-YRYPNWS 714
           YG  RF ++IE MIG++P    K+ W F+TP +      FS  ++ P+ Y + Y YP W 
Sbjct: 476 YGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWG 535

Query: 715 MVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCS-----PQPDWGPFLAQHRGER 769
             +GW +   S++ +P+  VI +    G F +RL+ + +     PQP   P L    G  
Sbjct: 536 YSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRN 595

Query: 770 Y 770
           +
Sbjct: 596 F 596


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  526 bits (1354), Expect = e-149
 Identities = 270/601 (44%), Positives = 381/601 (63%), Gaps = 41/601 (6%)

Query: 180 QEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLAL 239
           QEDE  D+ K RG W++K++F+LS+ G  +GLGNVWRFPYL ++NGGGAF IPY +   +
Sbjct: 27  QEDE--DQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFV 84

Query: 240 AGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYL 298
            G+P+FFLEV+LGQ+ SQG V+ W+ I P  QG G+A ++I   + +YY +I+ + LFYL
Sbjct: 85  CGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYL 144

Query: 299 FASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVN 358
           F+SF S LPW +CNN WNT  C D                    N +   T  P     N
Sbjct: 145 FSSFTSELPWTTCNNFWNTEHCTD------------------FLNHSGAGTVTP---FEN 183

Query: 359 FTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTS 418
           FTS           E+++  VL I++GI   G +RW LALCL LAWVI Y  + KG+K++
Sbjct: 184 FTSPV--------MEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKST 235

Query: 419 GKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSL 478
           GKVVYFTATFPY++LVILLIRGVTLPGA  GI Y++ P   +L D  VW DA TQIFFS 
Sbjct: 236 GKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSF 295

Query: 479 SAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENV 538
           +   G L  L SYNK+HNNCY+D + +   NSATS  AGFV+FS++GFM+ E+ V I  V
Sbjct: 296 AICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEV 355

Query: 539 ADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYL 598
           A+ GPG+AF+ +P+A+T +PLS  W+ +FF+ML+ LGLD+ F  +E +VT+  D FP+ L
Sbjct: 356 AESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQL 415

Query: 599 RT--HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYV 655
           R    + +  L   +  +++G  ++T+GG+Y+FQL D YA+S   L+ +++FE+V IS+V
Sbjct: 416 RKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWV 475

Query: 656 YGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGS-YRYPNWS 714
           YG  RF ++IE MIG++P    K+ W F+TP +      FS  ++ P+ Y + Y YP W 
Sbjct: 476 YGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWG 535

Query: 715 MVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCS-----PQPDWGPFLAQHRGER 769
             +GW +   S++ +P+  VI +    G F +RL+ + +     PQP   P L    G  
Sbjct: 536 YSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRN 595

Query: 770 Y 770
           +
Sbjct: 596 F 596


>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score =  523 bits (1347), Expect = e-148
 Identities = 250/567 (44%), Positives = 370/567 (65%), Gaps = 29/567 (5%)

Query: 191 RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVS 250
           R  W  K+DF+LS+VG+AV L NVWRFPYL ++NGGGAFLIPY + L +AG+P+F++E++
Sbjct: 56  RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115

Query: 251 LGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGS 310
           LGQ+  +G  +VWK  P  +G G A+++I++ +  YYNVII ++L+YLF+SF   LPW  
Sbjct: 116 LGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTD 175

Query: 311 CNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSG 370
           C + WN+P C D    LL+  V+ +H K                +   FT  A       
Sbjct: 176 CGHTWNSPNCTDPK--LLNGSVLGNHTKY---------------SKYKFTPAA------- 211

Query: 371 SEEYFKYFVLKI--SAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATF 428
             E+++  VL +  S+GI   G  +W L LCL +  +++Y SL KG+KTSGKVV+ TAT 
Sbjct: 212 --EFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATL 269

Query: 429 PYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITL 488
           PY VL +LL+ GVTLPGA  GI  ++   + +L +ATVW DAATQIFFSL A +G LI  
Sbjct: 270 PYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAF 329

Query: 489 SSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFV 548
           +SYNKF NNCYRD L+ +  N  TS  +GF IFS++G+MA+E KVNIE+VA +G G+ F+
Sbjct: 330 ASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFI 389

Query: 549 VYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLG 608
           +YPEA++ L  S FWA++FF+MLL LGLD+    +E ++T ++D+F + L+ H+ +FT G
Sbjct: 390 LYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDF-QVLKRHRKLFTFG 448

Query: 609 CCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMM 668
                F++    IT+GGIY+  L+DT+AA  +++   + E +G+S+ YG+ RF  DI+ M
Sbjct: 449 VTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQM 508

Query: 669 IGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIW 728
           +GF+P ++W++CW FV+P  L F++  S   ++P+TY  Y +P W+  +GW +   S++ 
Sbjct: 509 MGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVL 568

Query: 729 IPIMFVIKMHLAPGRFIERLKLVCSPQ 755
           +PI  + K     G   ERL    +P+
Sbjct: 569 VPIYVIYKFLSTQGSLWERLAYGITPE 595


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  522 bits (1344), Expect = e-148
 Identities = 254/580 (43%), Positives = 376/580 (64%), Gaps = 32/580 (5%)

Query: 181 EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA 240
           EDE   +   R  WSSK+DF+LS+ G  VGLGNVWRFPYL ++NGGGAFLIPY + L  +
Sbjct: 31  EDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGS 90

Query: 241 GLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLF 299
           GLP+FFLE+ +GQ+ S+G ++ W+ I P   G G A ++I  L+ +YY VI+ +  +YLF
Sbjct: 91  GLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLF 150

Query: 300 ASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNF 359
            SF   LPW  CN+ WNTP C + T                 KN +  +T    ++  NF
Sbjct: 151 QSFQKELPWAHCNHSWNTPHCMEDTMR---------------KNKSVWIT----ISSTNF 191

Query: 360 TSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSG 419
           TS           E+++  VL +S GI++PG ++W LALCL L W++ +  + KG++++G
Sbjct: 192 TSPVI--------EFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTG 243

Query: 420 KVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLS 479
           KVVYFTATFP+ +L++LL+RG+TLPGAGAGI +++ P   +L D  VW DA TQIFFS +
Sbjct: 244 KVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYA 303

Query: 480 AAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVA 539
              G + +L SYNK+  N YRD +++ C NS TS  +GF IFS++GFMA E+ V+I +VA
Sbjct: 304 ICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVA 363

Query: 540 DQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLR 599
           + GPG+AF+ YP+A+T +PL  FW+I+FF+MLL LGLD+ F  +E  +TS+ D +P +LR
Sbjct: 364 ESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLR 423

Query: 600 T--HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYVY 656
               + +F    C   +++G  M+T+GG+Y+FQL D YAAS   L+ +A FE   I+++Y
Sbjct: 424 KGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIY 483

Query: 657 GLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYG-SYRYPNWSM 715
           G     + IE MIG++P  + K  WA +TP +      FS  ++ P+TY  +Y YPNW++
Sbjct: 484 GGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAI 543

Query: 716 VLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQ 755
            LGW +   S++ +P++ VI++    G F+ R+K + +P+
Sbjct: 544 GLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPR 583


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  522 bits (1344), Expect = e-148
 Identities = 254/580 (43%), Positives = 376/580 (64%), Gaps = 32/580 (5%)

Query: 181 EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA 240
           EDE   +   R  WSSK+DF+LS+ G  VGLGNVWRFPYL ++NGGGAFLIPY + L  +
Sbjct: 31  EDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGS 90

Query: 241 GLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLF 299
           GLP+FFLE+ +GQ+ S+G ++ W+ I P   G G A ++I  L+ +YY VI+ +  +YLF
Sbjct: 91  GLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLF 150

Query: 300 ASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNF 359
            SF   LPW  CN+ WNTP C + T                 KN +  +T    ++  NF
Sbjct: 151 QSFQKELPWAHCNHSWNTPHCMEDTMR---------------KNKSVWIT----ISSTNF 191

Query: 360 TSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSG 419
           TS           E+++  VL +S GI++PG ++W LALCL L W++ +  + KG++++G
Sbjct: 192 TSPVI--------EFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTG 243

Query: 420 KVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLS 479
           KVVYFTATFP+ +L++LL+RG+TLPGAGAGI +++ P   +L D  VW DA TQIFFS +
Sbjct: 244 KVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYA 303

Query: 480 AAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVA 539
              G + +L SYNK+  N YRD +++ C NS TS  +GF IFS++GFMA E+ V+I +VA
Sbjct: 304 ICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVA 363

Query: 540 DQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLR 599
           + GPG+AF+ YP+A+T +PL  FW+I+FF+MLL LGLD+ F  +E  +TS+ D +P +LR
Sbjct: 364 ESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLR 423

Query: 600 T--HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYVY 656
               + +F    C   +++G  M+T+GG+Y+FQL D YAAS   L+ +A FE   I+++Y
Sbjct: 424 KGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIY 483

Query: 657 GLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYG-SYRYPNWSM 715
           G     + IE MIG++P  + K  WA +TP +      FS  ++ P+TY  +Y YPNW++
Sbjct: 484 GGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAI 543

Query: 716 VLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQ 755
            LGW +   S++ +P++ VI++    G F+ R+K + +P+
Sbjct: 544 GLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPR 583


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  520 bits (1338), Expect = e-147
 Identities = 252/574 (43%), Positives = 367/574 (63%), Gaps = 32/574 (5%)

Query: 187 ENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFF 246
           E + R  W  K+DF+LS++G+AV L NVWRFPYL ++NGGGAFL+PYL+ + +AG+P+F+
Sbjct: 56  EAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFY 115

Query: 247 LEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVL 306
           +E++LGQF  +G   VWK  P L+G G  +++IS+ +  +YNVII + L YLF+SF + L
Sbjct: 116 MELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTEL 175

Query: 307 PWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKT 366
           PW  CNN WN+P C D             HP     +S                S  N T
Sbjct: 176 PWIHCNNSWNSPNCSDA------------HPGDSSGDS----------------SGLNDT 207

Query: 367 F-VSGSEEYFKYFVLKI--SAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVY 423
           F  + + EYF+  VL +  S GI+  G  RW L  CL L  V++Y SL KG+KTSGKVV+
Sbjct: 208 FGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVW 267

Query: 424 FTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWG 483
            TAT PYVVL  LL+RGVTLPGA  GI  +++  + +L +A+VW DAATQ+ FSL   +G
Sbjct: 268 ITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFG 327

Query: 484 GLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGP 543
            LI  SSYNKF NNCYRD ++ T  NS TS  +GFV+FS +G+MA +  V I +VA  GP
Sbjct: 328 VLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGP 387

Query: 544 GIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKP 603
           G+ F++YPEA+  LPLS  WA++FF+MLLTLG+D+    +E+++T + DEF + L  H+ 
Sbjct: 388 GLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEF-QLLHRHRE 446

Query: 604 VFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCE 663
           +FTL   +  F++    +T GGIY+F L+D +AA  +++   + E +G+++ YG+ +F +
Sbjct: 447 LFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSD 506

Query: 664 DIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLA 723
           DI+ M G +P+++W++CW  V+P  L F++  S   + P  YG+Y +P+W+  LGW++  
Sbjct: 507 DIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIAT 566

Query: 724 CSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPD 757
            S+  +PI    K    PG F E+L    +P+ D
Sbjct: 567 SSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD 600


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  517 bits (1332), Expect = e-146
 Identities = 254/572 (44%), Positives = 365/572 (63%), Gaps = 33/572 (5%)

Query: 191 RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVS 250
           RG+W++K++F+LS+ G  +GLGNVWRFPYL ++NGGGAFLIPY++     G+P+FFLE +
Sbjct: 50  RGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETA 109

Query: 251 LGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWG 309
           LGQF S+G ++ W+ + P  +G G A  +I   + +YY +I+ + +FYL   F + LPW 
Sbjct: 110 LGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWA 169

Query: 310 SCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVS 369
           +C + WNT  C +  KL + +                    Y +V++ N TS        
Sbjct: 170 TCGHEWNTENCVEFQKLNVSN--------------------YSHVSLQNATSPVM----- 204

Query: 370 GSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFP 429
              E++++ VL IS GIE+ G +RW LALCL  AW I Y  + KG K++GKVVY TATFP
Sbjct: 205 ---EFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFP 261

Query: 430 YVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLS 489
           Y++L+ILLIRGVTLPGA  GI +++ P   +L+D  VW DA TQIFFS +   G L  L 
Sbjct: 262 YIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALG 321

Query: 490 SYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVV 549
           SYN ++NNCYRD +++ C NS TS  AGF IFSV+GFMA E+ V I  VA+ GPG+AF+ 
Sbjct: 322 SYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIA 381

Query: 550 YPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT--HKPVFTL 607
           YP+A+T +PLSP WA +FF+ML+ LGLD+ F  +E++VT++ D +PK  R    + +  L
Sbjct: 382 YPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLIL 441

Query: 608 GCCICFFIMGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYVYGLQRFCEDIE 666
              +  + +G  M+T+GG+Y+FQL D+YAAS   L+ +AIFE + I +VYG  RF ++IE
Sbjct: 442 ALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIE 501

Query: 667 MMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGS-YRYPNWSMVLGWLMLACS 725
            MIG++P    K CW  +TP I   I  F   +++P+ Y + Y YP W   +GWLM   S
Sbjct: 502 DMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSS 561

Query: 726 VIWIPIMFVIKMHLAPGRFIERLKLVCSPQPD 757
           ++ IP+   I +    G   E+L+ + +P  D
Sbjct: 562 MLCIPLWICITVWKTEGTLPEKLQKLTTPSTD 593


>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score =  514 bits (1323), Expect = e-145
 Identities = 256/599 (42%), Positives = 363/599 (60%), Gaps = 32/599 (5%)

Query: 191 RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVS 250
           R  W+ ++DFI+S VG+AVGLGNVWRFPYL ++NGGG FLIPY+++  + G+PIFFLE+S
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 251 LGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGS 310
           LGQF   G ++VW   P  +G G A ++I      YY +++ +  +YL  SF + LPW +
Sbjct: 112 LGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWAT 171

Query: 311 CNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSG 370
           C + WNTP+C                  ++I     C     N ++ N T        S 
Sbjct: 172 CGHTWNTPDC------------------VEIFRHEDCA----NASLANLTCDQLADRRSP 209

Query: 371 SEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPY 430
             E+++  VL++S G+E PG + W + LCL   WV+VY  + KG+K++GK+VYFTATFPY
Sbjct: 210 VIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPY 269

Query: 431 VVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSS 490
           VVLV+LL+RGV LPGA  GI Y++ P W KL    VW DA TQIFFS +   G L  L S
Sbjct: 270 VVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGS 329

Query: 491 YNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVY 550
           YN+F+NNCY+D +I+   NS TS FAGFV+FS++GFMA E+ V+I  VA+ GPG+AF+ Y
Sbjct: 330 YNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAY 389

Query: 551 PEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPK--YLRTHKPVFTLG 608
           P A+T +P++P WA +FF MLL LGLD+ F  +E  +T + D  P   Y R  + +    
Sbjct: 390 PRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVAL 449

Query: 609 CCICFFIMGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYVYGLQRFCEDIEM 667
           CC   F++   M+T GG+Y+FQL D Y+AS   L+  A +E V +++VYG  RF +DI  
Sbjct: 450 CCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIAC 509

Query: 668 MIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTY-GSYRYPNWSMVLGWLMLACSV 726
           MIG++P  + K CW+F TP +   I  F+   +EP+ Y  +Y YP W   +GW     S+
Sbjct: 510 MIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSM 569

Query: 727 IWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWG----PFLAQHRGERYKNMIDPLGTSS 781
           + +P+  +  +  A G   ER + +   QP WG     + AQ    R    + P+  SS
Sbjct: 570 LCVPLHLLGCLLRAKGTMAERWQHL--TQPIWGLHHLEYRAQDADVRGLTTLTPVSESS 626


>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score =  501 bits (1291), Expect = e-142
 Identities = 249/602 (41%), Positives = 362/602 (60%), Gaps = 49/602 (8%)

Query: 162 ATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLA 221
           A D     +P +  T+   E  QG+    R  W  K+DF+LS++GYAV LGNVWRFPY+ 
Sbjct: 55  AGDDTRHSIPATTTTLVA-ELHQGE----RETWGKKVDFLLSVIGYAVDLGNVWRFPYIC 109

Query: 222 FQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIIS 280
           +QNGGGAFL+PY +M    G+P+F++E++LGQ+   G +S+W+ I P  +G G A+ II+
Sbjct: 110 YQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIA 169

Query: 281 VLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQ 340
             IA YYN I+ + L+YL +SF   LPW SC N WNT  C                    
Sbjct: 170 FYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNC-------------------- 209

Query: 341 IKNSTFCMTAYPNVTMVNFTSQANKTFV----SGSEEYFKYFVLKI--SAGIEYPGEIRW 394
                            N+ S+ N T+     S +EE++   VL+I  S G++  G I W
Sbjct: 210 ----------------TNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISW 253

Query: 395 PLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFI 454
            LALC+ L + ++Y S+ KG+KTSGKVV+ TATFPY++L +LL+RG TLPGA  G+ +++
Sbjct: 254 QLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYL 313

Query: 455 TPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSI 514
            P W+KL +  VW DAA QIFFSL   +G L+  +SYNKF+NNCY+D L+ +  N  TS 
Sbjct: 314 KPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSF 373

Query: 515 FAGFVIFSVIGFMANERKVNIENVA-DQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLT 573
            +GFVIF+V+G+MA  R  ++  VA D GP + F+ Y EA+  +P S F+AIIFFLML+T
Sbjct: 374 VSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLIT 433

Query: 574 LGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVD 633
           LGLD+ FA +E ++T++ DEFP      +  F L   I  F      +T GG Y+ +L++
Sbjct: 434 LGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLE 493

Query: 634 TYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFIL 693
            YA   A++ +A+ E V +S+ YG+ +FC D++ M+GF P  FW++CW  ++P  L FI+
Sbjct: 494 EYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFII 553

Query: 694 CFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCS 753
           C        +    Y YP WS++LG+ +   S I IP     ++ + PG F ER+    +
Sbjct: 554 CSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSIT 613

Query: 754 PQ 755
           P+
Sbjct: 614 PE 615


>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score =  497 bits (1280), Expect = e-140
 Identities = 252/599 (42%), Positives = 357/599 (59%), Gaps = 42/599 (7%)

Query: 191 RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVS 250
           R  W+ ++DFI+S VG+AVGLGNVWRFPYL ++NGGG FLIPY+++  + G+PIFFLE+S
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 251 LGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGS 310
           LGQF   G ++VW   P  +G G A ++I      YY +++ +  +YL  SF + LPW +
Sbjct: 112 LGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWAT 171

Query: 311 CNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSG 370
           C + WNTP+C                  ++I     C     N ++ N T        S 
Sbjct: 172 CGHTWNTPDC------------------VEIFRHEDC----ANASLANLTCDQLADRRSP 209

Query: 371 SEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPY 430
             E+++  VL++S G+E PG + W + LCL   WV+VY  + KG+K++GK+VYFTATFPY
Sbjct: 210 VIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPY 269

Query: 431 VVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSS 490
           VVLV+LL+RGV LPGA  GI Y++ P W KL    VW DA TQIFFS +   G L  L S
Sbjct: 270 VVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGS 329

Query: 491 YNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVY 550
           YN+F+NNCY          + TS FAGFV+FS++GFMA E+ V+I  VA+ GPG+AF+ Y
Sbjct: 330 YNRFNNNCY----------NGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAY 379

Query: 551 PEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPK--YLRTHKPVFTLG 608
           P A+T +P++P WA +FF MLL LGLD+ F  +E  +T + D  P   Y R  + +    
Sbjct: 380 PRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVAL 439

Query: 609 CCICFFIMGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYVYGLQRFCEDIEM 667
           CC   F++   M+T GG+Y+FQL D Y+AS   L+  A +E V +++VYG  RF +DI  
Sbjct: 440 CCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIAC 499

Query: 668 MIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTY-GSYRYPNWSMVLGWLMLACSV 726
           MIG++P  + K CW+F TP +   I  F+   +EP+ Y  +Y YP W   +GW     S+
Sbjct: 500 MIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSM 559

Query: 727 IWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWG----PFLAQHRGERYKNMIDPLGTSS 781
           + +P+  +  +  A G   ER + +   QP WG     + AQ    R    + P+  SS
Sbjct: 560 LCVPLHLLGCLLRAKGTMAERWQHL--TQPIWGLHHLEYRAQDADVRGLTTLTPVSESS 616


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score =  417 bits (1073), Expect = e-116
 Identities = 214/532 (40%), Positives = 308/532 (57%), Gaps = 32/532 (6%)

Query: 258 GPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNT 317
           G ++VW   P  +G G A ++I      YY +++ +  +YL  SF + LPW +C + WNT
Sbjct: 4   GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63

Query: 318 PECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKY 377
           P+C                  ++I     C     N ++ N T        S   E+++ 
Sbjct: 64  PDC------------------VEIFRHEDCA----NASLANLTCDQLADRRSPVIEFWEN 101

Query: 378 FVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILL 437
            VL++S G+E PG + W + LCL   WV+VY  + KG+K++GK+VYFTATFPYVVLV+LL
Sbjct: 102 KVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLL 161

Query: 438 IRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNN 497
           +RGV LPGA  GI Y++ P W KL    VW DA TQIFFS +   G L  L SYN+F+NN
Sbjct: 162 VRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNN 221

Query: 498 CYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRL 557
           CY+D +I+   NS TS FAGFV+FS++GFMA E+ V+I  VA+ GPG+AF+ YP A+T +
Sbjct: 222 CYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLM 281

Query: 558 PLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPK--YLRTHKPVFTLGCCICFFI 615
           P++P WA +FF MLL LGLD+ F  +E  +T + D  P   Y R  + +    CC   F+
Sbjct: 282 PVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFV 341

Query: 616 MGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPN 674
           +   M+T GG+Y+FQL D Y+AS   L+  A +E V +++VYG  RF +DI  MIG++P 
Sbjct: 342 IDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPC 401

Query: 675 IFWKVCWAFVTPTILTFILCFSFYQWEPMTY-GSYRYPNWSMVLGWLMLACSVIWIPIMF 733
            + K CW+F TP +   I  F+   +EP+ Y  +Y YP W   +GW     S++ +P+  
Sbjct: 402 PWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHL 461

Query: 734 VIKMHLAPGRFIERLKLVCSPQPDWG----PFLAQHRGERYKNMIDPLGTSS 781
           +  +  A G   ER + +   QP WG     + AQ    R    + P+  SS
Sbjct: 462 LGCLLRAKGTMAERWQHL--TQPIWGLHHLEYRAQDADVRGLTTLTPVSESS 511


>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score =  401 bits (1030), Expect = e-111
 Identities = 235/649 (36%), Positives = 336/649 (51%), Gaps = 117/649 (18%)

Query: 159 VVLATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFP 218
           +VL   G+ + +P S+A + T E E   E  +R  W +K  ++L+ +G+ VGLGNVWRFP
Sbjct: 4   LVLPNPGLDARIP-SLAELETIEQE---EASSRPKWDNKAQYMLTCLGFCVGLGNVWRFP 59

Query: 219 YLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAML 277
           YL   +GGGAF+IP+L++L L G+P+ +LE ++GQ   +G + VW +I PAL+G G+A +
Sbjct: 60  YLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASM 119

Query: 278 IISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHP 337
           + S ++ +YYN II + ++YLF SF   LPW  C  P N                     
Sbjct: 120 LTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDC--PLNE-------------------- 157

Query: 338 KIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYF-VLKISAGIEYPGEIRWPL 396
                               N T   ++   S   +YF Y   L IS  I   G I+W +
Sbjct: 158 --------------------NQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWM 197

Query: 397 ALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITP 456
            LCL  AW ++Y    +GI+T+GK VY T+T PYVVL I LIRG+TL GA  GI +  TP
Sbjct: 198 LLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTP 257

Query: 457 KWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFA 516
              +L     W DA  Q+FFS S A+GGLI+ SSYN  HNNC +D++IV+  N  TS++ 
Sbjct: 258 NVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYV 317

Query: 517 GFVIFSVIGFMANER---------------------KVNIENVAD--------------- 540
             V++SVIGF A +R                      V  EN  D               
Sbjct: 318 AIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQ 377

Query: 541 ----------------QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIE 584
                           +G G+AF+V+ EA+T++PLSP W+++FF+ML  LGL +MF  +E
Sbjct: 378 LVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNME 437

Query: 585 TIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVII 644
            +V  + D      +  K V T   C+  F++GF      G Y   L+D+YA S  L+II
Sbjct: 438 GVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLII 497

Query: 645 AIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQ----- 699
           A  E+  + YVYG+ RF +DIE MIG +PNIFW+V W  V+P ++  I  F F       
Sbjct: 498 AFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQE 557

Query: 700 -----WEPMTYGSY------RYPNWSMVLGWLMLACSVIWIPIMFVIKM 737
                W+P  Y  +       YPNW  V+  ++     + IP   + K+
Sbjct: 558 LTYSIWDP-GYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKL 605


>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score =  390 bits (1003), Expect = e-108
 Identities = 223/617 (36%), Positives = 322/617 (52%), Gaps = 117/617 (18%)

Query: 185 GDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPI 244
           GDE   R  W +K  ++LS  G+AVGLGN+WRFPYL    GGGAFLIPY++ L   G+PI
Sbjct: 15  GDE---RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPI 71

Query: 245 FFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFV 303
           F +E+++GQ   +G V VW AI P L G G+  + +S LI++YYN I+ + L+YL  SF 
Sbjct: 72  FHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQ 131

Query: 304 SVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQA 363
             LPW SC                                        P++    F  + 
Sbjct: 132 HPLPWSSCP---------------------------------------PDLNRTGFVEEC 152

Query: 364 NKTFVSGSEEYFKYF-VLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVV 422
                S +  YF Y   L I+A I   G I+W L +CL  +W +VY  + +GI+T+GKV+
Sbjct: 153 QG---SSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVI 209

Query: 423 YFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAW 482
           YFTA FPY+VL I LIRG+TLPGA  G+ Y  TP    L +  VW DAATQIFFSLS A+
Sbjct: 210 YFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAF 269

Query: 483 GGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAN------------- 529
           GG I  +SYN   N+C +D +++   N  TS++A   +FSV+GF A              
Sbjct: 270 GGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILS 329

Query: 530 --------ERKVN----------------------------IENVADQ---GPGIAFVVY 550
                   E+ ++                            +E+  D+   GPG+AFVV+
Sbjct: 330 LINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVF 389

Query: 551 PEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISD--EFPKYLRTHKPVFTLG 608
            E    +P +P WA++FF ML TLGL TMF T+E ++T + D    P+++   K   T  
Sbjct: 390 TETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPRWV--PKEALTGL 447

Query: 609 CCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMM 668
            C+  F+       Q G Y  ++ D +AAS  L+++A  E+VG+ YVYG++RFC+DI  M
Sbjct: 448 VCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWM 507

Query: 669 IGFQPNIFWKVCWAFVTPTILT-FILCFSFYQWEPMTYGSYR-------------YPNWS 714
            G +P+ +W++ W  V+P +LT F+       W+P+ Y ++              YP W+
Sbjct: 508 TGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWA 567

Query: 715 MVLGWLMLACSVIWIPI 731
                L+    V+W+P+
Sbjct: 568 RAACVLLSLLPVLWVPV 584


>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  365 bits (937), Expect = e-101
 Identities = 211/591 (35%), Positives = 309/591 (52%), Gaps = 104/591 (17%)

Query: 189 KARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLE 248
           KAR  W++ L F+ + + YAVGLGNVWRFPYL    GGG+FL+PY++ML + G+P+ +LE
Sbjct: 3   KARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLE 62

Query: 249 VSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLP 307
           +++GQ   QG +  W+ I P L G G+A +++S  +++YYNVI  +  +YLF SF   LP
Sbjct: 63  LAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLP 122

Query: 308 WGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTF 367
           W  C  P N                                         N T    +  
Sbjct: 123 WSVC--PLNG----------------------------------------NHTGYDEECE 140

Query: 368 VSGSEEYFKYF-VLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTA 426
            + S +YF Y   L IS  ++  G ++W  ALCL LAW++VY  + +G +++GKVVYFTA
Sbjct: 141 KASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTA 200

Query: 427 TFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLI 486
           + PY VL+I LIRG+TL GA  G+ Y  TPK E+L +   W +AATQIFFSL   +G LI
Sbjct: 201 SLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLI 260

Query: 487 TLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAN------ERKV------- 533
             +SYN+  NNC +  +IV+  NS TSIFA  V FS+ GF A        +KV       
Sbjct: 261 AFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNT 320

Query: 534 -----------NIENV------------------------------ADQGPGIAFVVYPE 552
                      N+E V                              A QG G+AF+VY E
Sbjct: 321 FDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTE 380

Query: 553 ALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCIC 612
           A+  + +S  W++++F MLL LG+ +M      I+T ++D   K + +H P   +   +C
Sbjct: 381 AIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDS--KIISSHLPKEAISGLVC 438

Query: 613 FF--IMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIG 670
                +G     + G Y F + + YAA+ +L++I + E + + YVYGL+RF  D++ M G
Sbjct: 439 LVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTG 498

Query: 671 FQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLM 721
              + +WKV WA V+P  L  +  F FY  + +  G+ +Y  W    G L+
Sbjct: 499 RAVSWYWKVMWAGVSP--LLIVSLFVFYLSDYILTGTLKYQAWDASQGQLV 547


>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score =  313 bits (803), Expect = 3e-85
 Identities = 202/639 (31%), Positives = 316/639 (49%), Gaps = 129/639 (20%)

Query: 178 ATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMML 237
           A +E+   ++  A   W+SKL +IL+ +G++VGLGN+WRFPYL  +NGGGA+L+PYL++L
Sbjct: 50  AVEEELDAEDRPA---WNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLL 106

Query: 238 ALAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLF 296
            + G+P+FFLE+++GQ   +G + VW  I P L G G +  I+ + + +YYNVII +++F
Sbjct: 107 IIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIF 166

Query: 297 YLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTM 356
           Y F SF   LPW  C                         P ++            N ++
Sbjct: 167 YFFKSFQYPLPWSEC-------------------------PVVR------------NGSV 189

Query: 357 VNFTSQANKTFVSGSEEYFKYF-VLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGI 415
               ++  K   S +  YF Y   L IS  I   G + W + LCL +AW IV  ++ KGI
Sbjct: 190 AVVEAECEK---SSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGI 246

Query: 416 KTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIF 475
           ++SGKV+YF++ FPYVVL   L+RG+ L GA  GI +  TPK +K+ D  VW++AATQ+F
Sbjct: 247 QSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVF 306

Query: 476 FSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNI 535
           F+L   +GG+I  SSYNK  NNC+ D  +V+  N  TS+ A  V+F+V+GF AN   +N 
Sbjct: 307 FALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKAN--IMNE 364

Query: 536 ENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTS------ 589
           + V +    I   +    L+R  + P    + F  L T     M+  I T+         
Sbjct: 365 KCVVENAEKILGYLNTNVLSRDLIPPH---VNFSHLTTKDYMEMYNVIMTVKEDQFSALG 421

Query: 590 -----ISDEFPKYLR-------------THKPVFTLGCCICFFIM------GFPMITQGG 625
                + DE  K ++             TH P       + FF+M      G  + T  G
Sbjct: 422 LDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPF-WSVMFFLMLINLGLGSMIGTMAG 480

Query: 626 I------------------------------------YMFQLVDTYAASYALVIIAIFEL 649
           I                                    Y   + D Y+A+  L +I I E 
Sbjct: 481 ITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILEN 540

Query: 650 VGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQW--EPMTYGS 707
           + ++++YG ++F +++  M+GF+P  F+   W FV+P  +  +   S  Q    P  Y +
Sbjct: 541 IAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSA 600

Query: 708 Y----------RYPNWSMVLGWLMLACSVIWIPIMFVIK 736
           +           +PNW+M L   ++  + + IP++FV++
Sbjct: 601 WIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLR 639


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score =  302 bits (773), Expect = 9e-82
 Identities = 187/591 (31%), Positives = 282/591 (47%), Gaps = 141/591 (23%)

Query: 189 KARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLE 248
           KAR  W++ L F+ + + YAVGLGNVWRFPYL    GGG+FL+PY++ML + G+P+ +LE
Sbjct: 3   KARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLE 62

Query: 249 VSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLP 307
           +++GQ   QG +  W+ I P L G G+A +++S  +++YYNVI  +  +YLF SF   LP
Sbjct: 63  LAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLP 122

Query: 308 WGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTF 367
           W  C  P N                                         N T    +  
Sbjct: 123 WSVC--PLNG----------------------------------------NHTGYDEECE 140

Query: 368 VSGSEEYFKY-FVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTA 426
            + S +YF Y   L IS  ++  G ++W  ALCL LAW++VY  + +G +++GK+     
Sbjct: 141 KASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKI----- 195

Query: 427 TFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLI 486
                                           E+L +   W +AATQIFFSL   +G LI
Sbjct: 196 --------------------------------EQLANPKAWINAATQIFFSLGLGFGSLI 223

Query: 487 TLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAN------ERKV------- 533
             +SYN+  NNC +  +IV+  NS TSIFA  V FS+ GF A        +KV       
Sbjct: 224 AFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNT 283

Query: 534 -----------NIENV------------------------------ADQGPGIAFVVYPE 552
                      N+E V                              A QG G+AF+VY E
Sbjct: 284 FDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTE 343

Query: 553 ALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCIC 612
           A+  + +S  W++++F MLL LG+ +M      I+T ++D   K + +H P   +   +C
Sbjct: 344 AIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDS--KIISSHLPKEAISGLVC 401

Query: 613 FF--IMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIG 670
                +G     + G Y F + + YAA+ +L++I + E + + YVYGL+RF  D++ M G
Sbjct: 402 LVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTG 461

Query: 671 FQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLM 721
              + +WKV WA V+P  L  +  F FY  + +  G+ +Y  W    G L+
Sbjct: 462 RAVSWYWKVMWAGVSP--LLIVSLFVFYLSDYILTGTLKYQAWDASQGQLV 510


>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score =  273 bits (697), Expect = 6e-73
 Identities = 143/352 (40%), Positives = 206/352 (58%), Gaps = 40/352 (11%)

Query: 179 TQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLA 238
           T  +E  +    R  W+SKL +IL+ VG++VGLGNVWRFPYL  +NGGGA+L+PYL++L 
Sbjct: 49  TDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLM 108

Query: 239 LAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFY 297
           + G+P+FFLE+S+GQ   +G + VW  I P L G G A  ++   +A+YYNVII ++LFY
Sbjct: 109 VIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFY 168

Query: 298 LFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMV 357
              SF   LPW  C                         P ++  + TF     P     
Sbjct: 169 FSQSFQQPLPWDQC-------------------------PLVKNASHTF---VEPECEQS 200

Query: 358 NFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKT 417
           + T+            Y+    L IS+ I   G + W + +CL  AWV+V  ++ KGI++
Sbjct: 201 SATTY-----------YWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQS 249

Query: 418 SGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFS 477
           SGK++YF++ FPYVVL+  LIR   L G+  GI +  TPK E + +  VW++AATQ+FF+
Sbjct: 250 SGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFA 309

Query: 478 LSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAN 529
           L   +GG+I  SSYNK  NNC+ D ++V+  N  TS+ A  V+F+V+GF AN
Sbjct: 310 LGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKAN 361



 Score =  151 bits (381), Expect = 3e-36
 Identities = 75/221 (33%), Positives = 128/221 (57%), Gaps = 17/221 (7%)

Query: 529 NERKVNIE-NVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIV 587
           N  K+  E N A QG G+AF+ + EA+T  P SPFW+++FFLML+ LGL +MF TIE IV
Sbjct: 424 NSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIV 483

Query: 588 TSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIF 647
           T I D F    +  K + T+ CC+  F +G   + + G Y   + D Y+A+  L+I+ I 
Sbjct: 484 TPIVDTF----KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVIL 539

Query: 648 ELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQW--EPMTY 705
           E + + +VYG+ +F ED++ M+GF P+ ++   W +++P +L  +L  S       P  Y
Sbjct: 540 ENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGY 599

Query: 706 GSY----------RYPNWSMVLGWLMLACSVIWIPIMFVIK 736
            ++           YP W +V+   ++  +++ +P++F+++
Sbjct: 600 NAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 640


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  228 bits (580), Expect = 2e-59
 Identities = 184/704 (26%), Positives = 302/704 (42%), Gaps = 147/704 (20%)

Query: 138 KGTLERNNTPVVGWVNMSQSTVVLATDGIT-----SVLPGSVATVATQ----------ED 182
           KG+L R+ T       +S + V  A    +     SVL    A+   Q          E 
Sbjct: 35  KGSLTRSATSWTSEAQVSAARVAEAQARTSQPKQISVLEALTASALNQKPTHEKVQMTEK 94

Query: 183 EQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGL 242
           ++ +   AR  WSSK ++IL+ VG+++    +WRF YL   +GG +F   Y+ ML L G+
Sbjct: 95  KESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGV 154

Query: 243 PIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLFAS 301
           P+ FLE++ GQ   QG + VWK I P + G G +  ++  ++ +Y+NV+  + +FY+  S
Sbjct: 155 PLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQS 214

Query: 302 FVSVLPWGSCNNPWNT----PECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMV 357
           F   +PW  C    N+    PEC+  T                           P++   
Sbjct: 215 FQFPVPWEKCPLTMNSSGFDPECERTT---------------------------PSI--- 244

Query: 358 NFTSQANKTFVSGSEEYFKYF-VLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIK 416
                           YF Y   LK S  IE  G   + L L  FL W +V A +  G+K
Sbjct: 245 ----------------YFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLK 288

Query: 417 TSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFF 476
           ++GKV+Y     P  ++V   IR + L GA  G+   +  K   + + +VW  A  Q+  
Sbjct: 289 STGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLS 348

Query: 477 SLSAAWGG-------------------------LITLSSYNKF-------------HNNC 498
           +     G                          L+TL  +  F             H  C
Sbjct: 349 NTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCC 408

Query: 499 YRDTLI-----------------VTCTNSATSIFAGFV------IFSVIGFMANERKVNI 535
            R+  I                 V    + TSI+  ++      I S++  +    + NI
Sbjct: 409 ERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMV--LREVTECNI 466

Query: 536 ENV---ADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISD 592
           E     A +GP  AF+ + EA++ LP S FW+ IFFLMLL +GL +    ++ I+T + D
Sbjct: 467 ETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQD 526

Query: 593 EFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGI 652
            F  + R H  +  +G  +  F+ G       G Y  +L+  Y   + ++++ +FE + +
Sbjct: 527 TF-SFFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAV 585

Query: 653 SYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTIL--TFILCFSFYQWEPMTYGSY-- 708
           S+ YG +RF  D+ +++G   +  +   W  + P +L   F+        +P+TY S+  
Sbjct: 586 SWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDS 645

Query: 709 --------RYPNWSMVLGWLMLACSVIWIPIMFV-IKMHLAPGR 743
                    YP W+++L   + A  ++ IP  FV  ++H  P R
Sbjct: 646 STSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCRIHRIPFR 689


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score =  201 bits (510), Expect = 3e-51
 Identities = 110/290 (37%), Positives = 160/290 (55%), Gaps = 40/290 (13%)

Query: 241 GLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLF 299
           G+P+FFLE+S+GQ   +G + VW  I P L G G A  ++   +A+YYNVII ++LFY  
Sbjct: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63

Query: 300 ASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNF 359
            SF   LPW  C                         P ++  + TF     P     + 
Sbjct: 64  QSFQQPLPWDQC-------------------------PLVKNASHTF---VEPECEQSSA 95

Query: 360 TSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSG 419
           T+            Y+    L IS+ I   G + W + +CL  AWV+V  ++ KGI++SG
Sbjct: 96  TTY-----------YWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSG 144

Query: 420 KVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLS 479
           K++YF++ FPYVVL+  LIR   L G+  GI +  TPK E + +  VW++AATQ+FF+L 
Sbjct: 145 KIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALG 204

Query: 480 AAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAN 529
             +GG+I  SSYNK  NNC+ D ++V+  N  TS+ A  V+F+V+GF AN
Sbjct: 205 LGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKAN 254



 Score =  151 bits (381), Expect = 3e-36
 Identities = 75/221 (33%), Positives = 128/221 (57%), Gaps = 17/221 (7%)

Query: 529 NERKVNIE-NVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIV 587
           N  K+  E N A QG G+AF+ + EA+T  P SPFW+++FFLML+ LGL +MF TIE IV
Sbjct: 317 NSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIV 376

Query: 588 TSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIF 647
           T I D F    +  K + T+ CC+  F +G   + + G Y   + D Y+A+  L+I+ I 
Sbjct: 377 TPIVDTF----KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVIL 432

Query: 648 ELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQW--EPMTY 705
           E + + +VYG+ +F ED++ M+GF P+ ++   W +++P +L  +L  S       P  Y
Sbjct: 433 ENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGY 492

Query: 706 GSY----------RYPNWSMVLGWLMLACSVIWIPIMFVIK 736
            ++           YP W +V+   ++  +++ +P++F+++
Sbjct: 493 NAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 533


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  169 bits (428), Expect = 9e-42
 Identities = 94/266 (35%), Positives = 140/266 (52%), Gaps = 55/266 (20%)

Query: 179 TQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLA 238
           T  +E  +    R  W+SKL +IL+ VG++VGLGNVWRFPYL  +NGGGA+L+PYL++L 
Sbjct: 49  TDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLM 108

Query: 239 LAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFY 297
           + G+P+FFLE+S+GQ   +G + VW  I P L G G A  ++   +A+YYNVII ++LFY
Sbjct: 109 VIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFY 168

Query: 298 LFASFVSVLPWGSC------NNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAY 351
              SF   LPW  C      ++ +  PEC+                              
Sbjct: 169 FSQSFQQPLPWDQCPLVKNASHTFVEPECEQS---------------------------- 200

Query: 352 PNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASL 411
                            S +  Y+    L IS+ I   G + W + +CL  AWV+V  ++
Sbjct: 201 -----------------SATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAM 243

Query: 412 AKGIKTSGKVVYFTATFPYVVLVILL 437
            KGI++SGKV   +   P+++L+I +
Sbjct: 244 IKGIQSSGKV---SMLEPFLILLITI 266


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score =  167 bits (423), Expect = 4e-41
 Identities = 75/145 (51%), Positives = 100/145 (68%), Gaps = 1/145 (0%)

Query: 181 EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA 240
           EDE   +   R  WSSK+DF+LS+ G  VGLGNVWRFPYL ++NGGGAFLIPY + L  +
Sbjct: 31  EDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGS 90

Query: 241 GLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLF 299
           GLP+FFLE+ +GQ+ S+G ++ W+ I P   G G A ++I  L+ +YY VI+ +  +YLF
Sbjct: 91  GLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLF 150

Query: 300 ASFVSVLPWGSCNNPWNTPECKDKT 324
            SF   LPW  CN+ WNTP C + T
Sbjct: 151 QSFQKELPWAHCNHSWNTPHCMEDT 175


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.445 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,274,865
Number of Sequences: 37866
Number of extensions: 1539852
Number of successful extensions: 12215
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 416
Number of HSP's that attempted gapping in prelim test: 10918
Number of HSP's gapped (non-prelim): 1462
length of query: 797
length of database: 18,247,518
effective HSP length: 110
effective length of query: 687
effective length of database: 14,082,258
effective search space: 9674511246
effective search space used: 9674511246
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.