Guide to the Human Genome
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Search of human proteins with 9257240

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|9257240 neuroplastin isoform a precursor [Homo sapiens]
         (282 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|9257240 neuroplastin isoform a precursor [Homo sapiens]            573   e-164
gi|238624149 neuroplastin isoform d precursor [Homo sapiens]          558   e-159
gi|6912646 neuroplastin isoform b precursor [Homo sapiens]            518   e-147
gi|238624147 neuroplastin isoform c precursor [Homo sapiens]          503   e-142
gi|38372919 basigin isoform 1 precursor [Homo sapiens]                176   2e-44
gi|38372925 basigin isoform 2 precursor [Homo sapiens]                176   2e-44
gi|38372923 basigin isoform 4 [Homo sapiens]                          161   5e-40
gi|38348215 embigin [Homo sapiens]                                     69   5e-12
gi|110349719 titin isoform N2-A [Homo sapiens]                         69   6e-12
gi|109150416 peroxidasin [Homo sapiens]                                67   1e-11
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi...    60   3e-09
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap...    60   3e-09
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]         57   2e-08
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                    57   2e-08
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...    57   2e-08
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...    55   5e-08
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...    55   5e-08
gi|118572606 hemicentin 1 [Homo sapiens]                               55   7e-08
gi|126517478 peroxidasin homolog-like [Homo sapiens]                   55   7e-08
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ...    55   9e-08
gi|45594240 limbic system-associated membrane protein [Homo sapi...    54   1e-07
gi|19743806 roundabout 1 isoform b [Homo sapiens]                      54   2e-07
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ...    54   2e-07
gi|4506569 roundabout 1 isoform a [Homo sapiens]                       54   2e-07
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi...    54   2e-07
gi|110349717 titin isoform novex-2 [Homo sapiens]                      53   3e-07
gi|110349713 titin isoform novex-1 [Homo sapiens]                      53   3e-07
gi|110349715 titin isoform N2-B [Homo sapiens]                         53   3e-07
gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap...    53   3e-07
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                    52   4e-07

>gi|9257240 neuroplastin isoform a precursor [Homo sapiens]
          Length = 282

 Score =  573 bits (1478), Expect = e-164
 Identities = 282/282 (100%), Positives = 282/282 (100%)

Query: 1   MSGSSLPSALALSLLLVSGSLLPGPGAAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSS 60
           MSGSSLPSALALSLLLVSGSLLPGPGAAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSS
Sbjct: 1   MSGSSLPSALALSLLLVSGSLLPGPGAAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSS 60

Query: 61  HTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKA 120
           HTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKA
Sbjct: 61  HTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKA 120

Query: 121 APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
           APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN
Sbjct: 121 APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180

Query: 181 YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVI 240
           YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVI
Sbjct: 181 YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVI 240

Query: 241 IVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN 282
           IVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN
Sbjct: 241 IVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN 282


>gi|238624149 neuroplastin isoform d precursor [Homo sapiens]
          Length = 278

 Score =  558 bits (1439), Expect = e-159
 Identities = 278/282 (98%), Positives = 278/282 (98%), Gaps = 4/282 (1%)

Query: 1   MSGSSLPSALALSLLLVSGSLLPGPGAAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSS 60
           MSGSSLPSALALSLLLVSGSLLPGPGAAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSS
Sbjct: 1   MSGSSLPSALALSLLLVSGSLLPGPGAAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSS 60

Query: 61  HTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKA 120
           HTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKA
Sbjct: 61  HTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKA 120

Query: 121 APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
           APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN
Sbjct: 121 APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180

Query: 181 YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVI 240
           YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVI
Sbjct: 181 YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVI 240

Query: 241 IVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN 282
           IVVYEKRKRPDEVPD    AGPMKTNSTNNHKDKNLRQRNTN
Sbjct: 241 IVVYEKRKRPDEVPD----AGPMKTNSTNNHKDKNLRQRNTN 278


>gi|6912646 neuroplastin isoform b precursor [Homo sapiens]
          Length = 398

 Score =  518 bits (1333), Expect = e-147
 Identities = 251/252 (99%), Positives = 252/252 (100%)

Query: 31  EPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRIN 90
           +PRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRIN
Sbjct: 147 KPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRIN 206

Query: 91  KPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPH 150
           KPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPH
Sbjct: 207 KPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPH 266

Query: 151 PDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSAS 210
           PDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSAS
Sbjct: 267 PDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSAS 326

Query: 211 VVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNN 270
           VVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNN
Sbjct: 327 VVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNN 386

Query: 271 HKDKNLRQRNTN 282
           HKDKNLRQRNTN
Sbjct: 387 HKDKNLRQRNTN 398



 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 76/235 (32%), Positives = 96/235 (40%), Gaps = 52/235 (22%)

Query: 1   MSGSSLPSALALSLLLVSGSLLPGPGAAQNEPRIVT--SEEVIIRDSPVLPVTLQCNLTS 58
           MSGSSLPSALALSLLLVSGSLLPGPGAAQN   + +  SE  +  D+      L C++  
Sbjct: 1   MSGSSLPSALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDA----FELYCDVVG 56

Query: 59  S-SHTLTYSYWTKNGVEL-------SATRKNASNMEY--------RINKPRAEDSGEYHC 102
           S +  + + Y   N  E        +  R+   N  Y        RI +   EDSG Y C
Sbjct: 57  SPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYEC 116

Query: 103 VYHFVSAPKAN--------------ATIEVKAAPDI-TGHKRSENKNEGQDATMYCKSVG 147
                + PK N              ATI V   P I T  +     +     T+ C    
Sbjct: 117 --RASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRDSPVLPVTLQCNLTS 174

Query: 148 YPHPDWIWRKKENGMPMDIV--NTSGRFFIINKENYTELNIVNLQITEDPGEYEC 200
             H        +NG+ +     N S   + INK              ED GEY C
Sbjct: 175 SSHTLTYSYWTKNGVELSATRKNASNMEYRINKPR-----------AEDSGEYHC 218



 Score = 30.4 bits (67), Expect = 1.8
 Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 7/82 (8%)

Query: 130 SENKNEGQDATMYCKSVGYPHPDWIWRKKENGMP---MDIVNTSGRFFIINKENYTELNI 186
           SE K  G    +YC  VG P P+  W   E         + + + +  +     Y    +
Sbjct: 39  SETKLTGDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGV 98

Query: 187 VNLQIT----EDPGEYECNATN 204
             L+IT    ED G YEC A+N
Sbjct: 99  SVLRITRLTLEDSGTYECRASN 120


>gi|238624147 neuroplastin isoform c precursor [Homo sapiens]
          Length = 394

 Score =  503 bits (1294), Expect = e-142
 Identities = 247/252 (98%), Positives = 248/252 (98%), Gaps = 4/252 (1%)

Query: 31  EPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRIN 90
           +PRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRIN
Sbjct: 147 KPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRIN 206

Query: 91  KPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPH 150
           KPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPH
Sbjct: 207 KPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPH 266

Query: 151 PDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSAS 210
           PDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSAS
Sbjct: 267 PDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSAS 326

Query: 211 VVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNN 270
           VVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPD    AGPMKTNSTNN
Sbjct: 327 VVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPD----AGPMKTNSTNN 382

Query: 271 HKDKNLRQRNTN 282
           HKDKNLRQRNTN
Sbjct: 383 HKDKNLRQRNTN 394



 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 76/235 (32%), Positives = 96/235 (40%), Gaps = 52/235 (22%)

Query: 1   MSGSSLPSALALSLLLVSGSLLPGPGAAQNEPRIVT--SEEVIIRDSPVLPVTLQCNLTS 58
           MSGSSLPSALALSLLLVSGSLLPGPGAAQN   + +  SE  +  D+      L C++  
Sbjct: 1   MSGSSLPSALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDA----FELYCDVVG 56

Query: 59  S-SHTLTYSYWTKNGVEL-------SATRKNASNMEY--------RINKPRAEDSGEYHC 102
           S +  + + Y   N  E        +  R+   N  Y        RI +   EDSG Y C
Sbjct: 57  SPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYEC 116

Query: 103 VYHFVSAPKAN--------------ATIEVKAAPDI-TGHKRSENKNEGQDATMYCKSVG 147
                + PK N              ATI V   P I T  +     +     T+ C    
Sbjct: 117 --RASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRDSPVLPVTLQCNLTS 174

Query: 148 YPHPDWIWRKKENGMPMDIV--NTSGRFFIINKENYTELNIVNLQITEDPGEYEC 200
             H        +NG+ +     N S   + INK              ED GEY C
Sbjct: 175 SSHTLTYSYWTKNGVELSATRKNASNMEYRINKPR-----------AEDSGEYHC 218



 Score = 30.4 bits (67), Expect = 1.8
 Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 7/82 (8%)

Query: 130 SENKNEGQDATMYCKSVGYPHPDWIWRKKENGMP---MDIVNTSGRFFIINKENYTELNI 186
           SE K  G    +YC  VG P P+  W   E         + + + +  +     Y    +
Sbjct: 39  SETKLTGDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGV 98

Query: 187 VNLQIT----EDPGEYECNATN 204
             L+IT    ED G YEC A+N
Sbjct: 99  SVLRITRLTLEDSGTYECRASN 120


>gi|38372919 basigin isoform 1 precursor [Homo sapiens]
          Length = 385

 Score =  176 bits (447), Expect = 2e-44
 Identities = 95/237 (40%), Positives = 142/237 (59%), Gaps = 8/237 (3%)

Query: 50  VTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSA 109
           + L C+L  S+  +T   W K GV L          E++++    +  GEY CV  F+  
Sbjct: 153 ILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSD--DQWGEYSCV--FLPE 208

Query: 110 PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPH-PDWIWRKKENGMPMDIVN 168
           P   A I++   P +   K SE+ NEG+ A + CKS   P   DW W K  +     ++N
Sbjct: 209 PMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMN 268

Query: 169 TS-GRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPF 227
            S  RFF+ + +  +EL+I NL +  DPG+Y CN T++ GS   +  LRVRSHLA LWPF
Sbjct: 269 GSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPF 328

Query: 228 LGILAEIIILVVIIVVYEKRKRPDEVPDDDEP-AGPMKTNSTN-NHKDKNLRQRNTN 282
           LGI+AE+++LV II +YEKR++P++V DDD+  + P+K++  + N K KN+RQRN++
Sbjct: 329 LGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS 385



 Score = 28.5 bits (62), Expect = 6.9
 Identities = 19/86 (22%), Positives = 37/86 (43%), Gaps = 15/86 (17%)

Query: 130 SENKNEGQDATMYCKSVGYPHPDWIW-----------RKKENGMPMDIVNTSGRFFIINK 178
           S+ +  G    ++C++VG P P+  W            +  +G  +D V+    +     
Sbjct: 31  SQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYH---- 86

Query: 179 ENYTELNIVNLQITEDPGEYECNATN 204
           ++      ++  + ED G YEC A+N
Sbjct: 87  QHAASTISIDTLVEEDTGTYECRASN 112


>gi|38372925 basigin isoform 2 precursor [Homo sapiens]
          Length = 269

 Score =  176 bits (447), Expect = 2e-44
 Identities = 95/237 (40%), Positives = 142/237 (59%), Gaps = 8/237 (3%)

Query: 50  VTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSA 109
           + L C+L  S+  +T   W K GV L          E++++    +  GEY CV  F+  
Sbjct: 37  ILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSD--DQWGEYSCV--FLPE 92

Query: 110 PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPH-PDWIWRKKENGMPMDIVN 168
           P   A I++   P +   K SE+ NEG+ A + CKS   P   DW W K  +     ++N
Sbjct: 93  PMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMN 152

Query: 169 TS-GRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPF 227
            S  RFF+ + +  +EL+I NL +  DPG+Y CN T++ GS   +  LRVRSHLA LWPF
Sbjct: 153 GSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPF 212

Query: 228 LGILAEIIILVVIIVVYEKRKRPDEVPDDDEP-AGPMKTNSTN-NHKDKNLRQRNTN 282
           LGI+AE+++LV II +YEKR++P++V DDD+  + P+K++  + N K KN+RQRN++
Sbjct: 213 LGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS 269


>gi|38372923 basigin isoform 4 [Homo sapiens]
          Length = 205

 Score =  161 bits (408), Expect = 5e-40
 Identities = 84/189 (44%), Positives = 122/189 (64%), Gaps = 6/189 (3%)

Query: 98  GEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPH-PDWIWR 156
           GEY CV  F+  P   A I++   P +   K SE+ NEG+ A + CKS   P   DW W 
Sbjct: 19  GEYSCV--FLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWY 76

Query: 157 KKENGMPMDIVNTS-GRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVL 215
           K  +     ++N S  RFF+ + +  +EL+I NL +  DPG+Y CN T++ GS   +  L
Sbjct: 77  KITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITL 136

Query: 216 RVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEP-AGPMKTNSTN-NHKD 273
           RVRSHLA LWPFLGI+AE+++LV II +YEKR++P++V DDD+  + P+K++  + N K 
Sbjct: 137 RVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKG 196

Query: 274 KNLRQRNTN 282
           KN+RQRN++
Sbjct: 197 KNVRQRNSS 205


>gi|38348215 embigin [Homo sapiens]
          Length = 327

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 63/242 (26%), Positives = 101/242 (41%), Gaps = 17/242 (7%)

Query: 50  VTLQCNLTSSSHTLTYSY-WTKNGVEL------SATRKNASNMEYRINKPRAEDSGEYHC 102
           V L C  T+S      +  W K+G +L      SAT       +YR     ++  G Y C
Sbjct: 84  VNLTCQFTTSGDLNAVNVTWKKDGEQLENNYLVSATGSTLYT-QYRFTIINSKQMGSYSC 142

Query: 103 VYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGM 162
            +      +     +V   P++ G  +      G    + CK       +W W    NG 
Sbjct: 143 FFREEKEQRGTFNFKV---PELHGKNKPLISYVGDSTVLTCKCQNCFPLNWTWYSS-NGS 198

Query: 163 PMDIVNTSGRFFIINKENYTELNIVNLQITEDPGE-YECNATNAIGSASVVTVLRVRSHL 221
               V      ++IN     E  +   Q+ E+ GE Y C A   +G +     L V S+L
Sbjct: 199 VKVPVGVQMNKYVINGTYANETKLKITQLLEEDGESYWCRALFQLGESEEHIELVVLSYL 258

Query: 222 APLWPFLGILAEIIILVVIIVVYE----KRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLR 277
            PL PFL I+AE+I+LV  I++ E    K+K+  +   + E    +K++ +N  ++   R
Sbjct: 259 VPLKPFLVIVAEVILLVATILLCEKYTQKKKKHSDEGKEFEQIEQLKSDDSNGIENNVPR 318

Query: 278 QR 279
            R
Sbjct: 319 HR 320


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 68.6 bits (166), Expect = 6e-12
 Identities = 53/167 (31%), Positives = 76/167 (45%), Gaps = 18/167 (10%)

Query: 50   VTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEY-------RINKPRAEDSGEYHC 102
            + L+C ++ S        W +N  EL  + K   NM +        IN+  AEDSG+Y C
Sbjct: 6382 IQLECKISGSPEIKVS--WFRNDSELHESWKY--NMSFINSVALLTINEASAEDSGDYIC 6437

Query: 103  VYHF-VSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENG 161
              H  V     +  + VKA P  T         +G D  + C+  G P  + +W K    
Sbjct: 6438 EAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQ 6497

Query: 162  MPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGS 208
                 V  S +F I +K   T L+I+NL+ + D GEY C ATN +GS
Sbjct: 6498 -----VRNSKKFKITSKHFDTSLHILNLEAS-DVGEYHCKATNEVGS 6538



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 39/129 (30%), Positives = 64/129 (49%), Gaps = 13/129 (10%)

Query: 95   EDSGEYHCVYHFVSAPKANAT-IEVKAAPDITGHKRSENKNEGQDATMYCKSVGYP--HP 151
            EDSG+Y C  H  +   +++T ++VK  P            +G D  + C+  G P  H 
Sbjct: 7371 EDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHV 7430

Query: 152  DWIWRKKENGMPMDIVNTSGRFFIINKENY-TELNIVNLQITEDPGEYECNATNAIGSAS 210
             W   K+E          SG+ + I  EN+ T ++I+N+    D GEY+C ATN +GS +
Sbjct: 7431 SWYKDKREL--------RSGKKYKIMSENFLTSIHILNVDAA-DIGEYQCKATNDVGSDT 7481

Query: 211  VVTVLRVRS 219
             V  + +++
Sbjct: 7482 CVGSIALKA 7490



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 41/173 (23%), Positives = 78/173 (45%), Gaps = 14/173 (8%)

Query: 52   LQCNLTSSSHTLTYSYWTKNGVELSATRKNA-----SNMEYRINKPRAEDSGEYHC-VYH 105
            L+C +  S        W +N  EL A+ K       S    ++N    EDSG++ C   +
Sbjct: 5443 LECKIAGSPEIRVV--WFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQN 5500

Query: 106  FVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMD 165
               +   +  + VK  P  +         +  + ++ C+  G P  + +W K +  +   
Sbjct: 5501 PAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQL--- 5557

Query: 166  IVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
               +S ++ I +K  +T ++I+N+  T D GEY C A N +GS + V  ++++
Sbjct: 5558 --RSSKKYKIASKNFHTSIHILNVD-TSDIGEYHCKAQNEVGSDTCVCTVKLK 5607



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 46/160 (28%), Positives = 67/160 (41%), Gaps = 16/160 (10%)

Query: 68    WTKNGVELSATRK-----NASNMEYRINKPRAEDSGEYHCVYHF---VSAPKANATI--E 117
             W  NGVEL+ + +     + S+    I +    D G   C+      +   + + T+  E
Sbjct: 33070 WVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKE 33129

Query: 118   VKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIIN 177
             +  AP      RS+N NEGQ+    C+  G P P+  W K  N +P+ I   S    I  
Sbjct: 33130 LSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFK--NNLPISI---SSNVSISR 33184

Query: 178   KENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRV 217
               N   L I N  ++ D G+Y   A N  G  S    L V
Sbjct: 33185 SRNVYSLEIRNASVS-DSGKYTIKAKNFRGQCSATASLMV 33223



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 40/162 (24%), Positives = 66/162 (40%), Gaps = 12/162 (7%)

Query: 68   WTKNGVELSATRK-NASNME----YRINKPRAEDSGEYHCVYHFVSAPKA-NATIEVKAA 121
            W KNG+ ++ +++ N +  E      I     ED+G+Y+C     S   + +A I +   
Sbjct: 7901 WKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEP 7960

Query: 122  PDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENY 181
            P           + G  A++ C+  G P     W K +  +      T+ +    N    
Sbjct: 7961 PYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRP---TTTYKMHFRNNVAT 8017

Query: 182  TELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAP 223
               N V++    D GEY C A N++G  S  T L V+    P
Sbjct: 8018 LVFNQVDIN---DSGEYICKAENSVGEVSASTFLTVQEQKLP 8056



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 50/197 (25%), Positives = 77/197 (39%), Gaps = 17/197 (8%)

Query: 31   EPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRIN 90
            EP  +  +   I+ +     TL+C +  +    T   W K+G EL++  K   +   +++
Sbjct: 7584 EPATIVEKPESIKVTTGDTCTLECTVAGTPELSTK--WFKDGKELTSDNKYKISFFNKVS 7641

Query: 91   KPRA-----EDSGEYHC-VYHFVSAPKANATIEVK---AAPDITGHKRSENKNEGQDATM 141
              +       DSG Y   V + V      A+++V      P  T   +  N   G    M
Sbjct: 7642 GLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVM 7701

Query: 142  YCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECN 201
             CK  G P     W  + N +      +SGR +     + T    VN+    D G+Y C 
Sbjct: 7702 ECKVYGSPPISVSWFHEGNEI------SSGRKYQTTLTDNTCALTVNMLEESDSGDYTCI 7755

Query: 202  ATNAIGSASVVTVLRVR 218
            ATN  GS      L VR
Sbjct: 7756 ATNMAGSDECSAPLTVR 7772



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 47/206 (22%), Positives = 88/206 (42%), Gaps = 30/206 (14%)

Query: 26   GAAQNEPRIVTSE--EVIIRDSPVLPV------TLQCNLTSSSHTLTYSYWTKNGVELSA 77
            G A ++  +   E  + I + SPVL +      T +C +T +        W  +G E++A
Sbjct: 4847 GTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVS--WYLDGNEITA 4904

Query: 78   TRKNASNM-----EYRINKPRAEDSGEYHC-VYHFVSAPKANATIEVKAAPDITGHKRSE 131
             +K+  +       ++I+  R E+SG Y C   +       +  ++VK  P      +  
Sbjct: 4905 IQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPV 4964

Query: 132  NKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQI 191
               +  D  + C+  G P  +  W K         + +S ++ + ++     +++ NL I
Sbjct: 4965 EVVKYSDVELECEVTGTPPFEVTWLKNNRE-----IRSSKKYTLTDR-----VSVFNLHI 5014

Query: 192  TE----DPGEYECNATNAIGSASVVT 213
            T+    D GEY+C  +N  GS S  T
Sbjct: 5015 TKCDPSDTGEYQCIVSNEGGSCSCST 5040



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 42/158 (26%), Positives = 67/158 (42%), Gaps = 13/158 (8%)

Query: 68   WTKNGVELSATRKNASNMEYRINK-----PRAEDSGEYHCVY-HFVSAPKANATIEVKAA 121
            W+K+G +L   +      E +I        + +DSG Y C   +   +   +AT+ V+  
Sbjct: 3677 WSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREP 3736

Query: 122  PDITGH-KRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
            P        S     G+ A ++CK  G P     W K  N   +   NT  R + +N E 
Sbjct: 3737 PSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFK--NNKELSESNTV-RMYFVNSEA 3793

Query: 181  YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
              ++  V +   ED G Y C A N +GS S  T + ++
Sbjct: 3794 ILDITDVKV---EDSGSYSCEAVNDVGSDSCSTEIVIK 3828



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 50/213 (23%), Positives = 86/213 (40%), Gaps = 31/213 (14%)

Query: 26   GAAQNEPRIVTSEEVIIRDSPVLPV----------TLQCNLTSSSHTLTYSYWTKNGVEL 75
            G A +  +++ SE  +     + PV          T +C++T ++       W K+  E+
Sbjct: 7195 GTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKIT--WAKDNREI 7252

Query: 76   --------SATRKNASNMEYRINKPRAEDSGEYHC-VYHFVSAPKANATIEVKAAPDITG 126
                    +     A+    ++ K    D+G+Y C   +       +A + V+  P    
Sbjct: 7253 RPGGNYKMTLVENTATLTVLKVGKG---DAGQYTCYASNIAGKDSCSAQLGVQEPPRFIK 7309

Query: 127  HKRSENKNEGQDATMY-CKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELN 185
                    +  + T Y CK  G P    +W K E       +  S +F +   ++   L 
Sbjct: 7310 KLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETE-----IQESSKFRMSFVDSVAVLE 7364

Query: 186  IVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
            + NL + ED G+Y C A NA GSAS  T L+V+
Sbjct: 7365 MHNLSV-EDSGDYTCEAHNAAGSASSSTSLKVK 7396



 Score = 45.1 bits (105), Expect = 7e-05
 Identities = 37/134 (27%), Positives = 60/134 (44%), Gaps = 8/134 (5%)

Query: 88   RINKPRAEDSGEYHC-VYHFVSAPKANATIEVKAAPDITGH-KRSENKNEGQDATMYCKS 145
            RI K    DSG+Y C   + V     +A + VK  P      + S+   +G+   + CK 
Sbjct: 6329 RILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKI 6388

Query: 146  VGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNA 205
             G P     W + ++ +     + S ++ + +  N   L  +N    ED G+Y C A N 
Sbjct: 6389 SGSPEIKVSWFRNDSEL-----HESWKYNM-SFINSVALLTINEASAEDSGDYICEAHNG 6442

Query: 206  IGSASVVTVLRVRS 219
            +G AS  T L V++
Sbjct: 6443 VGDASCSTALTVKA 6456



 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 39/162 (24%), Positives = 59/162 (36%), Gaps = 12/162 (7%)

Query: 68   WTKNGVELSATRK-NASNME----YRINKPRAEDSGEYHC-VYHFVSAPKANATIEVKAA 121
            W K+G  ++ + K N    E      I      D+G+Y C + +        A +     
Sbjct: 6019 WKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEP 6078

Query: 122  PDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENY 181
            P             G   ++ C+  G P     W K +  +         R +  N    
Sbjct: 6079 PYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRP---TPEYRTYFTNNVAT 6135

Query: 182  TELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAP 223
               N VN+    D GEY C A N+IG+AS  TV R++    P
Sbjct: 6136 LVFNKVNIN---DSGEYTCKAENSIGTASSKTVFRIQERQLP 6174



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 38/152 (25%), Positives = 65/152 (42%), Gaps = 20/152 (13%)

Query: 68   WTKNGVELSATRKNA-----SNMEYRINKPRAEDSGEYHC-VYHFVSAPKANATIEVKAA 121
            W  N  E+  + K+      S    R+     EDSGEY C   +   +   ++ + VK +
Sbjct: 4333 WFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKES 4392

Query: 122  PDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENY 181
            P  T   +     +  D  +  +  G P  +  W K         +  SGR +    + +
Sbjct: 4393 PYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNT------ILRSGRKY----KTF 4442

Query: 182  TELNIVNLQITE----DPGEYECNATNAIGSA 209
             + ++V+LQI +    D GEY+C  TN +GS+
Sbjct: 4443 IQDHLVSLQILKFVAADAGEYQCRVTNEVGSS 4474



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 47/206 (22%), Positives = 80/206 (38%), Gaps = 29/206 (14%)

Query: 20   SLLPGPGAAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATR 79
            S L  PG  Q  P      + I++ +P   +                 W K+ VEL +  
Sbjct: 5331 SFLVKPGRQQAIPDSTVEFKAILKGTPPFKIK----------------WFKDDVELVSGP 5374

Query: 80   KNASNME-----YRINKPRAEDSGEYHC-VYHFVSAPKANATIEVKAAPDITGH-KRSEN 132
            K    +E       +    A  +G+Y C V + V +      + V   P      + S+ 
Sbjct: 5375 KCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKI 5434

Query: 133  KNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQIT 192
               G  + + CK  G P    +W + E+ +P      S ++ +   ++   + + NL  T
Sbjct: 5435 VKAGDSSRLECKIAGSPEIRVVWFRNEHELP-----ASDKYRMTFIDSVAVIQMNNLS-T 5488

Query: 193  EDPGEYECNATNAIGSASVVTVLRVR 218
            ED G++ C A N  GS S  T + V+
Sbjct: 5489 EDSGDFICEAQNPAGSTSCSTKVIVK 5514



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 41/162 (25%), Positives = 66/162 (40%), Gaps = 14/162 (8%)

Query: 52   LQCNLTSSSHTLTYSYWTKNGVELSAT---RKNASNME--YRINKPRAEDSGEYHC-VYH 105
            L C L  S   +    W KN  ELS +   R    N E    I   + EDSG Y C   +
Sbjct: 3757 LHCKLKGSP--VIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVN 3814

Query: 106  FVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMD 165
             V +   +  I +K  P         +   G +A + C+  G    +  W K +      
Sbjct: 3815 DVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQ---- 3870

Query: 166  IVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIG 207
             + +S ++ + ++++   L I +   + D GEYEC   N +G
Sbjct: 3871 -IRSSKKYRLFSQKSLVCLEIFSFN-SADVGEYECVVANEVG 3910



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 42/150 (28%), Positives = 62/150 (41%), Gaps = 16/150 (10%)

Query: 68   WTKNGVELSATRK-NASNMEY----RINKPRAEDSGEYHCV----YHFVSAPKANATIEV 118
            W K G E+  + K +  + +Y     I + +  D GEY C     Y  VS   A  T+  
Sbjct: 3489 WFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCT-ATLTVTE 3547

Query: 119  KAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINK 178
               P      +S     G+ A   C   G P  + IW+K    +     + S  + I + 
Sbjct: 3548 AYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAAL-----SPSPNWRISDA 3602

Query: 179  ENYTELNIVNLQITEDPGEYECNATNAIGS 208
            EN   L + NL I +D G Y C A+N  G+
Sbjct: 3603 ENKHILELSNLTI-QDRGVYSCKASNKFGA 3631



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 42/159 (26%), Positives = 69/159 (43%), Gaps = 18/159 (11%)

Query: 68   WTKNGVELSATRK-----NASNMEYRINKPRAEDSGEYHCVYHFVSAPKA-NATIEVKAA 121
            W K+G E+S + K     +  ++   +N    ED+  Y C    V+   A +  + VK  
Sbjct: 5270 WFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEP 5329

Query: 122  PDITGHKRSENKNEGQDATMYCKSV--GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKE 179
            P      +   +    D+T+  K++  G P     W K       D+   SG    I  E
Sbjct: 5330 PSFL--VKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKD------DVELVSGPKCFIGLE 5381

Query: 180  NYTE-LNIVNLQITEDPGEYECNATNAIGSASVVTVLRV 217
              T  LN+ ++  ++  G+Y C+ TN +GS S  T+L V
Sbjct: 5382 GSTSFLNLYSVDASKT-GQYTCHVTNDVGSDSCTTMLLV 5419



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 51/187 (27%), Positives = 75/187 (40%), Gaps = 19/187 (10%)

Query: 31   EPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNME---- 86
            EP  +T E V I  +   P TLQ   + +      + W K+G EL+   K   ++     
Sbjct: 4577 EPATITEEAVSIDVTQGDPATLQVKFSGTKEIT--AKWFKDGQELTLGSKYKISVTDTVS 4634

Query: 87   -YRINKPRAEDSGEYHC-VYHFVSAPKANATIEVK---AAPDITGHKRSENKNEGQDATM 141
              +I     +DSGEY   V + V      A I V      P  T   +  +  +G    +
Sbjct: 4635 ILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDL 4694

Query: 142  YCKSVGYPHPDWI-WRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYEC 200
             C   G  HP  I W K +       ++ S ++     +N   L I  L+ T D G Y C
Sbjct: 4695 ECIVAG-SHPISIQWFKDDQE-----ISASEKYKFSFHDNTAFLEISQLEGT-DSGTYTC 4747

Query: 201  NATNAIG 207
            +ATN  G
Sbjct: 4748 SATNKAG 4754



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 42/178 (23%), Positives = 70/178 (39%), Gaps = 17/178 (9%)

Query: 50   VTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRI-----NKPRAEDSGEYHCVY 104
            V+LQC +  +   +T S W K   +L  T +  +     +     NK    DSGEY C  
Sbjct: 6096 VSLQCQVAGTPE-ITVS-WYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKA 6153

Query: 105  HFVSAPKANATI----EVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKEN 160
                   ++ T+    E +  P      +   +  G   T+ C+  G       W + + 
Sbjct: 6154 ENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYR-DG 6212

Query: 161  GMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
             +  D  N    F     +N   L I+   ++   G+Y C+A+N +G+AS    L  R
Sbjct: 6213 VLLRDDENLQTSFV----DNVATLKILQTDLSHS-GQYSCSASNPLGTASSSARLTAR 6265



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 40/181 (22%), Positives = 73/181 (40%), Gaps = 14/181 (7%)

Query: 49   PVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYR-----INKPRAEDSGEYHCV 103
            P+ L+   T +   ++ S W K+   +S + + +  M  +     I +   ED  +Y C+
Sbjct: 6943 PIVLEATYTGTP-PISVS-WIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCL 7000

Query: 104  YHFVSAPK-ANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGM 162
                +      A + V   P             G+ AT+ CK  G P     W K+   +
Sbjct: 7001 IENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKL 7060

Query: 163  PMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLA 222
                  ++  + +  K N   L ++N     D GEY C A N++G+ +   VL +++   
Sbjct: 7061 -----RSAPAYKMQFKNNVASL-VINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKL 7114

Query: 223  P 223
            P
Sbjct: 7115 P 7115



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 35/160 (21%), Positives = 67/160 (41%), Gaps = 14/160 (8%)

Query: 68    WTKNGVELSATRKNASNMEYR-----INKPRAEDSGEYHCVY-HFVSAPKANATIEVKAA 121
             W + G EL  +RK   + + R     +     ED G Y C+  + V   + ++ + ++A 
Sbjct: 30566 WYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQAT 30625

Query: 122   PDI-TGHKRSENKNEGQDATM--YCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINK 178
             P    G+   E       +T+  +   +G P P   W   +      ++  S    I N 
Sbjct: 30626 PQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQK-----LLQNSENITIENT 30680

Query: 179   ENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
             E+YT L + N+Q     G+Y+   +N  G+   +  + ++
Sbjct: 30681 EHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQ 30720



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 30/114 (26%), Positives = 58/114 (50%), Gaps = 16/114 (14%)

Query: 38   EEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINK-----P 92
            ++V +++     +T Q ++ +       S W +NG  L    ++ + +E++++K      
Sbjct: 8752 QDVTLKEGQTCTMTCQFSVPNVK-----SEWFRNGRILKPQGRHKTEVEHKVHKLTIADV 8806

Query: 93   RAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSEN--KNEGQDATMYCK 144
            RAED G+Y C Y  +   + +A + ++A P I   KR +N   +E Q AT  C+
Sbjct: 8807 RAEDQGQYTCKYEDL---ETSAELRIEAEP-IQFTKRIQNIVVSEHQSATFECE 8856



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 49/197 (24%), Positives = 76/197 (38%), Gaps = 31/197 (15%)

Query: 49   PVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYR-------INKPRAEDSGEYH 101
            P TLQC +  +        W K   +L +    A  M+++       INK    D GEY 
Sbjct: 7036 PATLQCKVDGTPEIRIS--WYKEHTKLRSAP--AYKMQFKNNVASLVINKVDHSDVGEYS 7091

Query: 102  C-VYHFVSAPKANATIEVKAA---PDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRK 157
            C   + V A  ++A + +KA    P      +  ++  G      C+  G       W K
Sbjct: 7092 CKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYK 7151

Query: 158  KENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDP----GEYECNATNAIGSASVVT 213
             +  +  D  N    F           N+  LQI +      G+Y C+A+N +G+AS   
Sbjct: 7152 -DGVLLKDDANLQTSFVH---------NVATLQILQTDQSHIGQYNCSASNPLGTASSSA 7201

Query: 214  VLRVRSHLAPLWPFLGI 230
             L +  H  P  PF  +
Sbjct: 7202 KLILSEHEVP--PFFDL 7216



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 47/178 (26%), Positives = 73/178 (41%), Gaps = 20/178 (11%)

Query: 50   VTLQCNLTSSSHTLTYSYWTKNGVEL-------SATRKNASNMEYRINKPRAEDSGEYHC 102
            V L+C ++ S+       W ++G E+       S+  +N   +   + +P   D+G Y C
Sbjct: 6758 VVLECRVSGSAPISVG--WFQDGNEIVSGPKCQSSFSENVCTLNLSLLEP--SDTGIYTC 6813

Query: 103  VYHFVS-APKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENG 161
            V   V+ + + +A + V+  P       S     G   T      G P     W K    
Sbjct: 6814 VAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRE 6873

Query: 162  M-PMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
            + P +  N S   F+      TEL +  +Q  E  G+Y C  TN  GSAS  T L V+
Sbjct: 6874 LVPGESCNISLEDFV------TELELFEVQPLES-GDYSCLVTNDAGSASCTTHLFVK 6924



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 27/110 (24%), Positives = 46/110 (41%), Gaps = 15/110 (13%)

Query: 114  ATIEVKAAPD-ITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKK----ENGMPMDIVN 168
            A +E+   P  +    ++    EG+  T+ C   GYP P   W ++    E+ +   I  
Sbjct: 934  APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 993

Query: 169  TSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
             SG   ++ +E +           ED G + C+A N  G+ S    L V+
Sbjct: 994  QSGIARLMIREAF----------AEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 44/195 (22%), Positives = 77/195 (39%), Gaps = 25/195 (12%)

Query: 42   IRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNME---------YRINKP 92
            ++++  LPV   C + S S  ++ S W K+G  L    K++ N++           I K 
Sbjct: 8066 VQETVGLPVVFDCAI-SGSEPISVS-WYKDGKPL----KDSPNVQTSFLDNTATLNIFKT 8119

Query: 93   RAEDSGEYHCVY-HFVSAPKANATI---EVKAAPDITGHKRSENKNEGQDATMYCKSVGY 148
                +G+Y C   + + +  ++A +   E K  P         +   G+ A   C   G 
Sbjct: 8120 DRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGT 8179

Query: 149  PHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGS 208
                  W K         + + G++ I   EN   L ++ +    D G+Y C A N +G 
Sbjct: 8180 QPIKVSWAKDSRE-----IRSGGKYQISYLENSAHLTVLKVD-KGDSGQYTCYAVNEVGK 8233

Query: 209  ASVVTVLRVRSHLAP 223
             S    L ++  L P
Sbjct: 8234 DSCTAQLNIKERLIP 8248



 Score = 37.7 bits (86), Expect = 0.011
 Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 4/86 (4%)

Query: 134   NEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITE 193
             +EG+  T+ C   G P P+  W     G         GRF I N ++ T L I+++Q  +
Sbjct: 33341 DEGKVLTVACAFTGEPTPEVTW---SCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQ-KQ 33396

Query: 194   DPGEYECNATNAIGSASVVTVLRVRS 219
             D G Y  +  N  GS S    + +RS
Sbjct: 33397 DGGLYTLSLGNEFGSDSATVNIHIRS 33422



 Score = 37.0 bits (84), Expect = 0.019
 Identities = 43/158 (27%), Positives = 64/158 (40%), Gaps = 13/158 (8%)

Query: 68   WTKNGVEL--SATR---KNASNMEYRINKPRAEDSGEYHC-VYHFVSAPKANATIEVKAA 121
            W K+  EL   A R   K+ ++    +   +A DSG Y C + + V    + AT+ VK  
Sbjct: 4801 WFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEP 4860

Query: 122  PD-ITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
            P  I           GQ  T  C+  G P     W    +G  +  +   G  FI   + 
Sbjct: 4861 PQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYL--DGNEITAIQKHGISFI---DG 4915

Query: 181  YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
                 I   ++ E+ G Y C A N  G+AS    L+V+
Sbjct: 4916 LATFQISGARV-ENSGTYVCEARNDAGTASCSIELKVK 4952



 Score = 37.0 bits (84), Expect = 0.019
 Identities = 25/99 (25%), Positives = 41/99 (41%), Gaps = 6/99 (6%)

Query: 121   APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
             AP I    +      G+ A + C+ VG P PD  W +    +         R + ++ + 
Sbjct: 30532 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKEL------IQSRKYKMSSDG 30585

Query: 181   YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
              T    V  +  ED G Y C ATN +G     + L +++
Sbjct: 30586 RTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQA 30624



 Score = 36.6 bits (83), Expect = 0.025
 Identities = 51/209 (24%), Positives = 78/209 (37%), Gaps = 23/209 (11%)

Query: 18   SGSLLPGPGAAQNEPRIVTSEEVIIRDSPVLPVTLQC-NLTSSSHTLTYSYWTKNGVELS 76
            SG+L+      Q  P  VT          VLP +  C   T    T     W K   EL 
Sbjct: 4197 SGALI-----VQEPPSFVTKPG----SKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELV 4247

Query: 77   A-----TRKNASNMEYRINKPRAEDSGEYHC-VYHFVSAPKANATIEVKA-APDITGHKR 129
            +       K A      +   +  DSG Y C V +     + +A + VK  A  +   + 
Sbjct: 4248 SGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEP 4307

Query: 130  SENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNL 189
            S+   +G    + CK  G P     W   +       +  S +  +   E+   L + ++
Sbjct: 4308 SQLLKKGDATQLACKVTGTPPIKITWFANDRE-----IKESSKHRMSFVESTAVLRLTDV 4362

Query: 190  QITEDPGEYECNATNAIGSASVVTVLRVR 218
             I ED GEY C A N  GS    +++ V+
Sbjct: 4363 GI-EDSGEYMCEAQNEAGSDHCSSIVIVK 4390



 Score = 35.8 bits (81), Expect = 0.043
 Identities = 39/143 (27%), Positives = 57/143 (39%), Gaps = 18/143 (12%)

Query: 116  IEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFI 175
            +E+KAAP I           G  A   C+    P+  + W K         +  S +  I
Sbjct: 3450 MEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGRE-----IYESDKCSI 3504

Query: 176  INKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAP--------LWPF 227
             + +  + L I+  Q+  D GEY C A+N  GS S    L V     P        L  F
Sbjct: 3505 RSSKYISSLEILRTQVV-DCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTF 3563

Query: 228  LGILAEIIILV----VIIVVYEK 246
            +G  A+ I  V    VI  +++K
Sbjct: 3564 VGKAAKFICTVTGTPVIETIWQK 3586



 Score = 35.4 bits (80), Expect = 0.057
 Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 7/108 (6%)

Query: 110   PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNT 169
             PK++  I+   AP      R+ N     +AT+ CK  G+P P   W ++   +  D +  
Sbjct: 30919 PKSDVPIQ---APHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKY 30975

Query: 170   SGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRV 217
               + F   K  Y +L I ++   +D   Y+  ATN  GS S    L V
Sbjct: 30976 RIQEF---KGGYHQLIIASV-TDDDATVYQVRATNQGGSVSGTASLEV 31019



 Score = 34.7 bits (78), Expect = 0.097
 Identities = 24/85 (28%), Positives = 37/85 (43%), Gaps = 5/85 (5%)

Query: 135  EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITED 194
            EGQ A    K VG P P+  W      +  D  +      ++ KE+ T+  I+      D
Sbjct: 1470 EGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHK-----VVIKEDGTQSLIIVPATPSD 1524

Query: 195  PGEYECNATNAIGSASVVTVLRVRS 219
             GE+   A N  G +S+  +L V +
Sbjct: 1525 SGEWTVVAQNRAGRSSISVILTVEA 1549



 Score = 34.7 bits (78), Expect = 0.097
 Identities = 39/155 (25%), Positives = 64/155 (41%), Gaps = 33/155 (21%)

Query: 68    WTKNGVELSATRKNASNMEYRIN-------KPRAEDSGEYHCVYHFVSAPK-ANATIEVK 119
             W +N + +    K+    E +I+       KPR  D GEY     F++  K A A +E+ 
Sbjct: 12944 WLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPR--DQGEYR----FIAKDKEARAKLELA 12997

Query: 120   AAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTS--------- 170
             AAP I    +    + G+  TM      YP  +  W K+   +    ++T+         
Sbjct: 12998 AAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDTTAEQTSFRIL 13057

Query: 171   -------GRFFII--NKENYTELNIVNLQITEDPG 196
                    GR+ I+  NK    E   +NL++ + PG
Sbjct: 13058 EAKKGDKGRYKIVLQNKHGKAE-GFINLKVIDVPG 13091



 Score = 33.5 bits (75), Expect = 0.22
 Identities = 43/189 (22%), Positives = 73/189 (38%), Gaps = 21/189 (11%)

Query: 31   EPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRIN 90
            EP  +     +I+ +   P TL+  +  +        W K+G  L A++K   + +  + 
Sbjct: 4015 EPAKIIERAELIQVTAGDPATLEYTVAGTPELKPK--WYKDGRPLVASKKYRISFKNNVA 4072

Query: 91   KPR-----AEDSGEYHC-VYHFVSAPKANATIEV---KAAPDITGHKRSENKNEGQDATM 141
            + +       DSG+Y   + + V +     T  V     AP  T   R+ +        +
Sbjct: 4073 QLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRL 4132

Query: 142  YCKSVGY--PHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYE 199
             CK  G       W    KE       +  S R+ I   E    L I+ + +  D G + 
Sbjct: 4133 DCKIAGSLPMRVSWFKDGKE-------IAASDRYRIAFVEGTASLEIIRVDMN-DAGNFT 4184

Query: 200  CNATNAIGS 208
            C ATN++GS
Sbjct: 4185 CRATNSVGS 4193



 Score = 32.3 bits (72), Expect = 0.48
 Identities = 30/145 (20%), Positives = 57/145 (39%), Gaps = 10/145 (6%)

Query: 74    ELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENK 133
             +++ TR++ S+ E+  +      + E   +    +  K   T+  +    I    RS   
Sbjct: 32517 QMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAAR----ILTKPRSMTV 32572

Query: 134   NEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITE 193
              EG+ A   C + G P P   W +K       +++TS R  +   +  +   I ++Q   
Sbjct: 32573 YEGESARFSCDTDGEPVPTVTWLRKG-----QVLSTSARHQVTTTKYKSTFEISSVQ-AS 32626

Query: 194   DPGEYECNATNAIGSASVVTVLRVR 218
             D G Y     N+ G       L ++
Sbjct: 32627 DEGNYSVVVENSEGKQEAEFTLTIQ 32651



 Score = 32.0 bits (71), Expect = 0.63
 Identities = 31/128 (24%), Positives = 46/128 (35%), Gaps = 7/128 (5%)

Query: 97   SGEYHCVYHFVSA-PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIW 155
            SG Y C     S   +  A + V+    I    +S +  E    T+ C   G P     W
Sbjct: 5115 SGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKW 5174

Query: 156  RKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVL 215
             K    +         R+F ++ EN      +   + +D G+Y     N  GS+S    L
Sbjct: 5175 LKDGKQI------VPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYL 5228

Query: 216  RVRSHLAP 223
            RV     P
Sbjct: 5229 RVLDQNIP 5236



 Score = 31.6 bits (70), Expect = 0.82
 Identities = 27/89 (30%), Positives = 39/89 (43%), Gaps = 7/89 (7%)

Query: 119  KAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINK 178
            K  PDI  +       EG+ A   C+  GYP P   W    NG    ++  S R F +  
Sbjct: 1838 KQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYL--NG---QLIRKSKR-FRVRY 1891

Query: 179  ENYTELNIVNLQITEDPGEYECNATNAIG 207
            +    L+IV+ + + D GE +  A N  G
Sbjct: 1892 DGIHYLDIVDCK-SYDTGEVKVTAENPEG 1919



 Score = 31.6 bits (70), Expect = 0.82
 Identities = 27/84 (32%), Positives = 38/84 (45%), Gaps = 7/84 (8%)

Query: 135   EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKE-NYTELNIVNLQITE 193
             EGQ      +  G P P   W K  +G P+ +        II++  +Y  L+I +  + E
Sbjct: 31808 EGQSVCFEIRVSGIPPPTLKWEK--DGQPLSL---GPNIEIIHEGLDYYALHIRDT-LPE 31861

Query: 194   DPGEYECNATNAIGSASVVTVLRV 217
             D G Y   ATN  GS S    L+V
Sbjct: 31862 DTGYYRVTATNTAGSTSCQAHLQV 31885



 Score = 31.2 bits (69), Expect = 1.1
 Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 8/80 (10%)

Query: 136   GQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQIT-ED 194
             G+D  +     G P P   WRK E  +  D      R+ I N ++ + L I   Q+T  D
Sbjct: 27286 GEDVQVLIPFKGRPPPTVTWRKDEKNLGSD-----ARYSIENTDSSSLLTIP--QVTRND 27338

Query: 195   PGEYECNATNAIGSASVVTV 214
              G+Y     N +G     TV
Sbjct: 27339 TGKYILTIENGVGEPKSSTV 27358



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 26/99 (26%), Positives = 43/99 (43%), Gaps = 5/99 (5%)

Query: 121  APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
            AP I    +S+   +G DA    + VG P P+  W K  NG+ ++   +   ++   ++N
Sbjct: 2077 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYK--NGVKIE--RSDRIYWYWPEDN 2132

Query: 181  YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
              EL ++     ED       A N  G  S    L V++
Sbjct: 2133 VCEL-VIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA 2170



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 39/162 (24%), Positives = 68/162 (41%), Gaps = 16/162 (9%)

Query: 60   SHTLTYSYWTKNGVELSATRKNASNMEYRINK-----PRAEDSGEYHCVYHFVSAPKANA 114
            SH    S W KNGVE+  + K    ++ ++++        EDS EY  V       + +A
Sbjct: 2906 SHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFV---CGNDQVSA 2962

Query: 115  TIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFF 174
            T+ V   P +      +   E +D   +  +V Y    + W K  NG+    + ++ +  
Sbjct: 2963 TLTV--TPIMITSMLKDINAEEKDTITFEVTVNYEGISYKWLK--NGVE---IKSTDKCQ 3015

Query: 175  IINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLR 216
            +  K+    LNI N+    D  +Y   A  A  +A++    R
Sbjct: 3016 MRTKKLTHSLNIRNVHF-GDAADYTFVAGKATSTATLYVEAR 3056



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 42/179 (23%), Positives = 66/179 (36%), Gaps = 38/179 (21%)

Query: 51    TLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYH--------- 101
             TL C +T   H      W + G E+ A       ++YRI     E  G YH         
Sbjct: 30946 TLVCKVTG--HPKPIVKWYRQGKEIIA-----DGLKYRIQ----EFKGGYHQLIIASVTD 30994

Query: 102   ---CVYHFVSAPKAN-----ATIEVKAAPDITGHKRSENKN-----EGQDATMYCKSVGY 148
                 VY   +  +       A++EV+    I   K  E         G+  ++     G 
Sbjct: 30995 DDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGK 31054

Query: 149   PHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIG 207
             P P   W+K +     D+++ +G + +I   ++T L   N    +D G Y   A N  G
Sbjct: 31055 PDPVITWQKGQ-----DLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFG 31108



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 27/110 (24%), Positives = 42/110 (38%), Gaps = 8/110 (7%)

Query: 110   PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNT 169
             PKA   I  K  P I    +    +    A    K+ G P P  IW K    +      T
Sbjct: 32842 PKAPEPISSK--PVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI------T 32893

Query: 170   SGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
              G  + ++++       ++   T D G Y C   N+ GS S    L +++
Sbjct: 32894 QGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKA 32943



 Score = 30.4 bits (67), Expect = 1.8
 Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 7/62 (11%)

Query: 147   GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAI 206
             G P P  +W K+E  +  D      R  I N    +EL I+   + +D G Y   ATN+ 
Sbjct: 15130 GRPVPTKVWTKEEGELDKD------RVVIDNVGTKSEL-IIKDALRKDHGRYVITATNSC 15182

Query: 207   GS 208
             GS
Sbjct: 15183 GS 15184



 Score = 29.6 bits (65), Expect = 3.1
 Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 6/99 (6%)

Query: 120 AAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKE 179
           A P+     +S    +G    +  +  G P P  + +   +G  +     S   F I++E
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTP--VVKFYRDGAEIQ----SSLDFQISQE 155

Query: 180 NYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
                 ++     ED G Y  NATN++G A+    L V+
Sbjct: 156 GDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 22/75 (29%), Positives = 32/75 (42%), Gaps = 5/75 (6%)

Query: 135  EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITED 194
            EG   T +CK  GYP P   W K  +G  +         F+ +      + +V   + ED
Sbjct: 1304 EGMGVTFHCKMSGYPLPKIAWYK--DGKRIKHGERYQMDFLQDGRASLRIPVV---LPED 1358

Query: 195  PGEYECNATNAIGSA 209
             G Y   A+N  G+A
Sbjct: 1359 EGIYTAFASNIKGNA 1373



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 17/71 (23%), Positives = 30/71 (42%), Gaps = 6/71 (8%)

Query: 147   GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAI 206
             G P P   W    + +  D        + +  +N++ +  +   +  D GEY+   +NA 
Sbjct: 17536 GVPVPTAKWTTDGSEIKTD------EHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAA 17589

Query: 207   GSASVVTVLRV 217
             GS +V   L V
Sbjct: 17590 GSKTVAVHLTV 17600



 Score = 28.9 bits (63), Expect = 5.3
 Identities = 23/82 (28%), Positives = 36/82 (43%), Gaps = 6/82 (7%)

Query: 136  GQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDP 195
            G  AT+     G P     W K  +G P+     S ++ I  K N  +L   + ++  D 
Sbjct: 4031 GDPATLEYTVAGTPELKPKWYK--DGRPLV---ASKKYRISFKNNVAQLKFYSAEL-HDS 4084

Query: 196  GEYECNATNAIGSASVVTVLRV 217
            G+Y    +N +GS+S  T   V
Sbjct: 4085 GQYTFEISNEVGSSSCETTFTV 4106



 Score = 28.9 bits (63), Expect = 5.3
 Identities = 36/161 (22%), Positives = 60/161 (37%), Gaps = 17/161 (10%)

Query: 68   WTKNGVELSATRK-----NASNMEYRINKPRAEDSGEYHC-VYHFVSAPKANATI---EV 118
            W KN +E+  T         + +  ++ K    D+G Y C V +   +    ++I   E 
Sbjct: 8283 WYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEP 8342

Query: 119  KAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGM-PMDIVNTSGRFFIIN 177
            K  P    H      +EG+   + C   G       W K    + P D  +    F   +
Sbjct: 8343 KKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCS----FSFAS 8398

Query: 178  KENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
                 EL  V      D G+Y C A+N  GS +  + + ++
Sbjct: 8399 GTAVLELRDV---AKADSGDYVCKASNVAGSDTTKSKVTIK 8436



 Score = 28.9 bits (63), Expect = 5.3
 Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 6/62 (9%)

Query: 147   GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAI 206
             G PHP   W+K E+    ++V +S     ++K + + + I+     +D G Y   A N+ 
Sbjct: 18924 GKPHPTCKWKKGED----EVVTSS--HLAVHKADSSSILIIKDVTRKDSGYYSLTAENSS 18977

Query: 207   GS 208
             G+
Sbjct: 18978 GT 18979



 Score = 28.5 bits (62), Expect = 6.9
 Identities = 28/103 (27%), Positives = 41/103 (39%), Gaps = 4/103 (3%)

Query: 121 APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
           AP  T   +S    EG  AT      G+P P+  W +  +G  +      G   I   + 
Sbjct: 5   APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFR--DGQVISTSTLPG-VQISFSDG 61

Query: 181 YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAP 223
             +L I  +    + G Y   ATN  G A+    L V++  AP
Sbjct: 62  RAKLTIPAVT-KANSGRYSLKATNGSGQATSTAELLVKAETAP 103



 Score = 28.1 bits (61), Expect = 9.0
 Identities = 18/71 (25%), Positives = 29/71 (40%), Gaps = 6/71 (8%)

Query: 96   DSGEYHCVYH------FVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYP 149
            DSGE+  V         +S       +E +  P      ++ N  EG    M  ++ G P
Sbjct: 1524 DSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNP 1583

Query: 150  HPDWIWRKKEN 160
            +PD +W K  +
Sbjct: 1584 NPDIVWLKNSD 1594



 Score = 28.1 bits (61), Expect = 9.0
 Identities = 21/64 (32%), Positives = 30/64 (46%), Gaps = 4/64 (6%)

Query: 147   GYPHPDWIWRKKENGM--PMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
             G P P   W K E  +  P D +  + +  +   E  TEL+I    + ED G Y   A+N
Sbjct: 15424 GLPMPKIEWSKNETVIEKPTDALQIT-KEEVSRSEAKTELSIPKA-VREDKGTYTVTASN 15481

Query: 205   AIGS 208
              +GS
Sbjct: 15482 RLGS 15485


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 59/207 (28%), Positives = 88/207 (42%), Gaps = 25/207 (12%)

Query: 27  AAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSY-----------WTKNGVEL 75
           A  N   +  +  +I++  P   VT Q  +     T+ +             WTK G +L
Sbjct: 414 ATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQL 473

Query: 76  SATRKNA--SNMEYRINKPRAEDSGEYHC-VYHFVSAPK--ANATIEVKAAPDITGHKRS 130
           S  R++   S+   RI+     D G+Y C   + + + K  A+ T++ +  P        
Sbjct: 474 SVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSD 533

Query: 131 ENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQ 190
                G +  + C S G P P   W K  +G+    V  SG+F I + E +  +N V   
Sbjct: 534 TTVEVGANVQLPCSSQGEPEPAITWNK--DGVQ---VTESGKFHI-SPEGFLTINDVG-- 585

Query: 191 ITEDPGEYECNATNAIGSASVVTVLRV 217
              D G YEC A N IGSASV  VL V
Sbjct: 586 -PADAGRYECVARNTIGSASVSMVLSV 611



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 41/131 (31%), Positives = 60/131 (45%), Gaps = 10/131 (7%)

Query: 96  DSGEYHC-VYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWI 154
           DSGEY C   + + +  A A I V+A P  T   +     EGQ     C++ G P P   
Sbjct: 406 DSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIA 465

Query: 155 WRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTV 214
           W K  + + +D      R  ++       ++ V L    D G+YEC A N IGS  VV  
Sbjct: 466 WTKGGSQLSVD------RRHLVLSSGTLRISGVALH---DQGQYECQAVNIIGSQKVVAH 516

Query: 215 LRVRSHLAPLW 225
           L V+  + P++
Sbjct: 517 LTVQPRVTPVF 527



 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 39/165 (23%), Positives = 63/165 (38%), Gaps = 25/165 (15%)

Query: 68  WTKNGVELSATRKNASNM----EYRINKPRAEDSGEYHCVYHFVSAPKANATIEVK---- 119
           W +N  ELS    +  N+       I   +  D G Y C+   V+       + ++    
Sbjct: 279 WLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGS 338

Query: 120 -AAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIW-RKKENGMPMD---IVNTSGRFF 174
            A P      ++     G+  T+ C + G+P P   W R     +P+D    +  SG  +
Sbjct: 339 PARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLY 398

Query: 175 IINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
           I N             +  D GEY C+ATN I S      + V++
Sbjct: 399 IQN------------VVQGDSGEYACSATNNIDSVHATAFIIVQA 431



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 27/93 (29%), Positives = 38/93 (40%), Gaps = 7/93 (7%)

Query: 122 PDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENY 181
           P IT   +  +   G      C++ G P P+ IW +  N + M    T  R  +++    
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM---KTDSRLNLLDDGT- 301

Query: 182 TELNIVNLQITEDPGEYECNATNAIGSASVVTV 214
             L I N Q T D G Y+C A N  G      V
Sbjct: 302 --LMIQNTQET-DQGIYQCMAKNVAGEVKTQEV 331


>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
           sapiens]
          Length = 848

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 58/237 (24%), Positives = 96/237 (40%), Gaps = 30/237 (12%)

Query: 10  LALSLLLVSGSLLPGPGAAQNEPRIVTSEEVIIRDSPVL---PVTLQC--NLTSSSHTLT 64
           L+ + L + G      G  + E RI+   E+  +D  V+   P T+Q   N+ +++  L 
Sbjct: 169 LSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLG 228

Query: 65  YSY---------------WTKNGVELSATRKNAS------NMEYRINKPRAEDSGEYHCV 103
            S                WTK+G ++     +        + +  I K    D  EY C+
Sbjct: 229 QSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288

Query: 104 YHFVSAPKANATIEVK--AAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENG 161
                A + +ATI +K  A P IT  +        +  T+ C++ G P P   WR     
Sbjct: 289 AEN-KAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347

Query: 162 MPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
           +  +     G   + +    + L + ++Q T D GEY C A+N IG  S    L V+
Sbjct: 348 ISSEEKTLDGHMVVRSHARVSSLTLKSIQYT-DAGEYICTASNTIGQDSQSMYLEVQ 403



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 35/156 (22%), Positives = 61/156 (39%), Gaps = 16/156 (10%)

Query: 54  CNLTSSSHTLTYSYWTKNGVELSATRKNAS-------NMEYRINKPRAEDSGEYHCVYHF 106
           C +   +     S+++ NG +L+  ++  S       +    I     +D+G Y CV   
Sbjct: 41  CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100

Query: 107 VSAPKANATIEVKAAPDI--TGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPM 164
               ++ AT+ VK    +        +   EG+DA + C  V    P  IW+ K      
Sbjct: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGR---- 156

Query: 165 DIVNTSGRFFIINKENYTELNIVNLQITEDPGEYEC 200
           D++      FI+   NY ++  +      D G Y C
Sbjct: 157 DVILKKDVRFIVLSNNYLQIRGIK---KTDEGTYRC 189



 Score = 37.7 bits (86), Expect = 0.011
 Identities = 33/131 (25%), Positives = 50/131 (38%), Gaps = 26/131 (19%)

Query: 96  DSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWI 154
           D+GEY C   + +     +  +EV+ AP + G        EG    + C+   YP     
Sbjct: 379 DAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSATIS 437

Query: 155 WRKKENGMPMDIVNTSGRFFIINKENYTELNIVN------LQITEDP----GEYECNATN 204
           W +    +P                NY+ + I N      L++T D     G Y C A N
Sbjct: 438 WFRDGQLLP--------------SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 483

Query: 205 AIGSASVVTVL 215
            IG  S+  +L
Sbjct: 484 RIGQESLEFIL 494


>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
           sapiens]
          Length = 761

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 58/237 (24%), Positives = 96/237 (40%), Gaps = 30/237 (12%)

Query: 10  LALSLLLVSGSLLPGPGAAQNEPRIVTSEEVIIRDSPVL---PVTLQC--NLTSSSHTLT 64
           L+ + L + G      G  + E RI+   E+  +D  V+   P T+Q   N+ +++  L 
Sbjct: 169 LSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLG 228

Query: 65  YSY---------------WTKNGVELSATRKNAS------NMEYRINKPRAEDSGEYHCV 103
            S                WTK+G ++     +        + +  I K    D  EY C+
Sbjct: 229 QSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288

Query: 104 YHFVSAPKANATIEVK--AAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENG 161
                A + +ATI +K  A P IT  +        +  T+ C++ G P P   WR     
Sbjct: 289 AEN-KAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347

Query: 162 MPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
           +  +     G   + +    + L + ++Q T D GEY C A+N IG  S    L V+
Sbjct: 348 ISSEEKTLDGHMVVRSHARVSSLTLKSIQYT-DAGEYICTASNTIGQDSQSMYLEVQ 403



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 35/156 (22%), Positives = 61/156 (39%), Gaps = 16/156 (10%)

Query: 54  CNLTSSSHTLTYSYWTKNGVELSATRKNAS-------NMEYRINKPRAEDSGEYHCVYHF 106
           C +   +     S+++ NG +L+  ++  S       +    I     +D+G Y CV   
Sbjct: 41  CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100

Query: 107 VSAPKANATIEVKAAPDI--TGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPM 164
               ++ AT+ VK    +        +   EG+DA + C  V    P  IW+ K      
Sbjct: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGR---- 156

Query: 165 DIVNTSGRFFIINKENYTELNIVNLQITEDPGEYEC 200
           D++      FI+   NY ++  +      D G Y C
Sbjct: 157 DVILKKDVRFIVLSNNYLQIRGIK---KTDEGTYRC 189



 Score = 37.7 bits (86), Expect = 0.011
 Identities = 33/131 (25%), Positives = 50/131 (38%), Gaps = 26/131 (19%)

Query: 96  DSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWI 154
           D+GEY C   + +     +  +EV+ AP + G        EG    + C+   YP     
Sbjct: 379 DAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSATIS 437

Query: 155 WRKKENGMPMDIVNTSGRFFIINKENYTELNIVN------LQITEDP----GEYECNATN 204
           W +    +P                NY+ + I N      L++T D     G Y C A N
Sbjct: 438 WFRDGQLLP--------------SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 483

Query: 205 AIGSASVVTVL 215
            IG  S+  +L
Sbjct: 484 RIGQESLEFIL 494


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 12/182 (6%)

Query: 32  PRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINK 91
           P  + S    +R     PV+L C +  +   L   +W K+G  L    +++   +  ++ 
Sbjct: 767 PPQIASSAPTVRVLEGQPVSLPC-IVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHL 825

Query: 92  PRA--EDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGY 148
            RA  E +G Y CV  +   +   +  + V+  P I         NEG  A++ C + G 
Sbjct: 826 DRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGV 885

Query: 149 PHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGS 208
           P P   W K+ N +      + G  + ++KE      ++     +D G Y C ATN +G 
Sbjct: 886 PAPTITWTKETNAL-----TSRGPHYNVSKEGTL---LIAQPSAQDAGAYVCTATNTVGF 937

Query: 209 AS 210
           +S
Sbjct: 938 SS 939



 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 40/157 (25%), Positives = 66/157 (42%), Gaps = 3/157 (1%)

Query: 68  WTKNGVELSATRKNASNMEYRINKPRAEDSGEYHC-VYHFVSAPKANATIEVKAAPDITG 126
           W + G+E+    + +S+ + RI   +  D+G Y C   + +    A   + V  AP +T 
Sbjct: 614 WYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTE 673

Query: 127 HKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNI 186
             R      G+ A + C++ G P P   WR+ + G P+ +   +GR     + +   L  
Sbjct: 674 LPRDVTVELGRSALLACRATGRPPPTVTWRRGD-GQPLGLRLGAGRGSRSRQPDSGVLFF 732

Query: 187 VNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAP 223
            ++   ED   Y C A N  G       L V  H  P
Sbjct: 733 ESV-APEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 45/185 (24%), Positives = 79/185 (42%), Gaps = 25/185 (13%)

Query: 32  PRIVTSEEVIIRDSPVLPVTLQCN-LTSSSHTLTYSYWTKNGVELSATRKNAS---NMEY 87
           P++V +  V +  SP     L C  L  + + LT   W ++   L A+    +   ++  
Sbjct: 401 PQLVPAPNVTV--SPGETAVLSCRVLGEAPYNLT---WVRDWRVLPASTGRVAQLADLSL 455

Query: 88  RINKPRAEDSGEYHCVYHFVSA-PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSV 146
            I+     D G Y CV    +   +A+  + V+ AP ++ H  S++ ++G +  + C + 
Sbjct: 456 EISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSAS 515

Query: 147 GYPHPDWIWRKKENGMPMDI---VNTSGRFFIINKENYTELNIVNLQITEDPGEYECNAT 203
           GYP P   W ++   +  D    V+  G              I+     ED G Y C AT
Sbjct: 516 GYPTPHISWSRESQALQEDSRIHVDAQGTL------------IIQGVAPEDAGNYSCQAT 563

Query: 204 NAIGS 208
           N +G+
Sbjct: 564 NEVGT 568



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 47/183 (25%), Positives = 79/183 (43%), Gaps = 23/183 (12%)

Query: 48   LPVTLQCNLTS-SSHTLTYSYWTK--NGVELSATRKNASNM-EYRINKPRAEDSGEYHCV 103
            +P +L C  +   + T+T   WTK  N +       N S      I +P A+D+G Y C 
Sbjct: 874  VPASLPCVASGVPAPTIT---WTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCT 930

Query: 104  YHFV---SAPKANATIEVKAAPDITGHKRSE-----NKNEGQDATMYCKSVGYPHPDWIW 155
                   S+ +   ++  K    + G + +          G++ T+ C++ G P P   W
Sbjct: 931  ATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTW 990

Query: 156  RKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVL 215
             K    +P      + R+ ++   +   L +  +Q+  D G YEC A+N  GSAS   VL
Sbjct: 991  TKDSRPVPP----ITNRYGLLPSGS---LRLAQVQVG-DSGHYECTASNPAGSASHRYVL 1042

Query: 216  RVR 218
             V+
Sbjct: 1043 GVQ 1045



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 32/127 (25%), Positives = 51/127 (40%), Gaps = 18/127 (14%)

Query: 95  EDSGEYHC-VYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDW 153
           ED+G Y C   + V   +   T+     P ++          G++A + C++ G P P  
Sbjct: 553 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRV 612

Query: 154 IWRKKENGMPMDIV---NTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSAS 210
           IW +   G+ M +    ++SG+  I   +              D G Y C A N +G AS
Sbjct: 613 IWYR--GGLEMILAPEGSSSGKLRIPAAQE------------RDAGTYTCRAVNELGDAS 658

Query: 211 VVTVLRV 217
               L V
Sbjct: 659 AEIQLAV 665



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 32/144 (22%), Positives = 56/144 (38%), Gaps = 17/144 (11%)

Query: 80  KNASNMEYRINKPRAEDSGEYHCV-YHFVSAPKANATIEVKAAPDITGHKRSENKNEGQD 138
           + + N  + I +    + G Y C         +A A I V   P       +   + G+ 
Sbjct: 357 QESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGET 416

Query: 139 ATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQIT----ED 194
           A + C+ +G    +  W +    +P     ++GR          +L  ++L+I+     D
Sbjct: 417 AVLSCRVLGEAPYNLTWVRDWRVLPA----STGRV--------AQLADLSLEISGIIPTD 464

Query: 195 PGEYECNATNAIGSASVVTVLRVR 218
            G Y+C A+NA G       L VR
Sbjct: 465 GGRYQCVASNANGVTRASVWLLVR 488


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 12/182 (6%)

Query: 32   PRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINK 91
            P  + S    +R     PV+L C +  +   L   +W K+G  L    +++   +  ++ 
Sbjct: 884  PPQIASSAPTVRVLEGQPVSLPC-IVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHL 942

Query: 92   PRA--EDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGY 148
             RA  E +G Y CV  +   +   +  + V+  P I         NEG  A++ C + G 
Sbjct: 943  DRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGV 1002

Query: 149  PHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGS 208
            P P   W K+ N +      + G  + ++KE      ++     +D G Y C ATN +G 
Sbjct: 1003 PAPTITWTKETNAL-----TSRGPHYNVSKEGTL---LIAQPSAQDAGAYVCTATNTVGF 1054

Query: 209  AS 210
            +S
Sbjct: 1055 SS 1056



 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 40/157 (25%), Positives = 66/157 (42%), Gaps = 3/157 (1%)

Query: 68  WTKNGVELSATRKNASNMEYRINKPRAEDSGEYHC-VYHFVSAPKANATIEVKAAPDITG 126
           W + G+E+    + +S+ + RI   +  D+G Y C   + +    A   + V  AP +T 
Sbjct: 731 WYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTE 790

Query: 127 HKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNI 186
             R      G+ A + C++ G P P   WR+ + G P+ +   +GR     + +   L  
Sbjct: 791 LPRDVTVELGRSALLACRATGRPPPTVTWRRGD-GQPLGLRLGAGRGSRSRQPDSGVLFF 849

Query: 187 VNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAP 223
            ++   ED   Y C A N  G       L V  H  P
Sbjct: 850 ESV-APEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 885



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 45/185 (24%), Positives = 79/185 (42%), Gaps = 25/185 (13%)

Query: 32  PRIVTSEEVIIRDSPVLPVTLQCN-LTSSSHTLTYSYWTKNGVELSATRKNAS---NMEY 87
           P++V +  V +  SP     L C  L  + + LT   W ++   L A+    +   ++  
Sbjct: 518 PQLVPAPNVTV--SPGETAVLSCRVLGEAPYNLT---WVRDWRVLPASTGRVAQLADLSL 572

Query: 88  RINKPRAEDSGEYHCVYHFVSA-PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSV 146
            I+     D G Y CV    +   +A+  + V+ AP ++ H  S++ ++G +  + C + 
Sbjct: 573 EISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSAS 632

Query: 147 GYPHPDWIWRKKENGMPMDI---VNTSGRFFIINKENYTELNIVNLQITEDPGEYECNAT 203
           GYP P   W ++   +  D    V+  G              I+     ED G Y C AT
Sbjct: 633 GYPTPHISWSRESQALQEDSRIHVDAQGTL------------IIQGVAPEDAGNYSCQAT 680

Query: 204 NAIGS 208
           N +G+
Sbjct: 681 NEVGT 685



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 46/160 (28%), Positives = 70/160 (43%), Gaps = 17/160 (10%)

Query: 68   WTKNGVELSA--TRKNASNMEYRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDI 124
            W K G+ ++   + +     + RI     ED+G Y C+  +   +      + V+  P I
Sbjct: 3981 WQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVI 4040

Query: 125  TGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTEL 184
                   +  EG  A + CK+ G P P+  W K  +G P  +    G+F I   +   EL
Sbjct: 4041 ENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK--DGQP--VSGAEGKFTI---QPSGEL 4093

Query: 185  NIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPL 224
             + NL+  +D G Y C A NA+G A      R R HL  L
Sbjct: 4094 LVKNLE-GQDAGTYTCTAENAVGRA------RRRVHLTIL 4126



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 41/162 (25%), Positives = 67/162 (41%), Gaps = 12/162 (7%)

Query: 67   YWTKNGVEL--SATRKNASNMEYRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPD 123
            +W K+G+ L  S  R    N    I++   +D+G Y C+  + +   K    + +++AP 
Sbjct: 4251 HWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPV 4310

Query: 124  ITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTE 183
                 +      G D  + C++ G P P   W +   G P+     S R   +   +   
Sbjct: 4311 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQA--GQPL---RASRRLRTLPDGSLWL 4365

Query: 184  LNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLW 225
             N+     T D G Y+C A N +GSA+    L VR      W
Sbjct: 4366 ENVE----TGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSW 4403



 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 48/194 (24%), Positives = 74/194 (38%), Gaps = 32/194 (16%)

Query: 25   PGAAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASN 84
            P   Q  PR++   +V++ ++      L  N  +  +      W+K+GV L       S 
Sbjct: 1119 PPQVQPGPRVL---KVLVGEA------LDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSV 1169

Query: 85   MEYRINKPRAEDSGEYHCVYHFVSAPKA-NATIEVKAAPDITGHKRSE--NKNEGQDATM 141
                I   R  D+G Y C     +   A    + V   P     + S    +  G++A++
Sbjct: 1170 HFAAI---RTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASL 1226

Query: 142  YCKSVGYPHPDWIWRKKEN-----GMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPG 196
             C + G P P   WRK  +     G P   V   G  F+ +                D G
Sbjct: 1227 PCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVS------------PADSG 1274

Query: 197  EYECNATNAIGSAS 210
            +YEC ATN +GS S
Sbjct: 1275 DYECQATNEVGSTS 1288



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 60/220 (27%), Positives = 87/220 (39%), Gaps = 25/220 (11%)

Query: 17   VSGSLLPGPGAAQNEPRIVTSEEVIIRDSPVL---PVTLQCNLTSS-SHTLTYSYWTKNG 72
            V+GS     G   N P  +T    +    PVL   PV L CN T + S TL    W K+G
Sbjct: 1961 VAGSTELRYGLRVNVPPRITLPPSL--PGPVLVNTPVRLTCNATGAPSPTLM---WLKDG 2015

Query: 73   VELSATRKNASNM-----EYRINKPRAEDSGEYHCV-YHFVSAPKANATIEVKAAPDITG 126
              +S        +        +   RA DSG Y CV    V   + +  ++V   P I G
Sbjct: 2016 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILG 2075

Query: 127  HKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNI 186
             + + +    +   + C+S   P P   W K  +G P++     G     +K     L  
Sbjct: 2076 EELNVSVVANESVALECQSHAMPPPVLSWWK--DGRPLE--PRPGVHLSADK----ALLQ 2127

Query: 187  VNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWP 226
            V+     D G Y C A N  G +     L V   +AP++P
Sbjct: 2128 VDRADVWDAGHYTCEALNQAGHSEKHYNLNV--WVAPVFP 2165



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 36/123 (29%), Positives = 57/123 (46%), Gaps = 9/123 (7%)

Query: 96   DSGEYHCVYHFVSAPKANA-TIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWI 154
            DSG+Y C     +   + A  +E+   P I     + N +  Q A + C++ G P P   
Sbjct: 3646 DSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVS 3705

Query: 155  WRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTV 214
            WRK  + +P+D    S RF I+ + +      +   + +D G Y C A+N+ GS      
Sbjct: 3706 WRK--DRVPLD--PRSPRFEILPEGSLR----IQPVLAQDAGHYLCLASNSAGSDRQGRD 3757

Query: 215  LRV 217
            LRV
Sbjct: 3758 LRV 3760



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 11/133 (8%)

Query: 88   RINKPRAEDSGEYHCVYHFVSAPKA-NATIEVKAAPDITGHKRSENKNEGQD--ATMYCK 144
            RI      D G Y CV    +  +A +  + V A P I G   +      +D    + C+
Sbjct: 1466 RITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCE 1525

Query: 145  SVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
            + G P P+  W K    +P     TS +  ++      +L +   Q + D G Y C A+N
Sbjct: 1526 ARGVPTPNITWFKDGALLP-----TSTK--VVYTRGGRQLQLGRAQ-SSDAGVYTCKASN 1577

Query: 205  AIGSASVVTVLRV 217
            A+G+A   T L V
Sbjct: 1578 AVGAAEKATRLDV 1590



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 41/167 (24%), Positives = 66/167 (39%), Gaps = 19/167 (11%)

Query: 52   LQCNLTSSSHTLTYSYWTKNGVELS---ATRKNASNMEYRINKPRAEDSGEYHCVY-HFV 107
            L CN+T   H      W K+G  L+   A   +   +  ++ +     +G Y C+  + V
Sbjct: 2465 LMCNVTG--HPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAV 2522

Query: 108  SAPKANATIEVKAAPDITGHKRSENKNE-----GQDATMYCKSVGYPHPDWIWRKKENGM 162
                 +  + V  AP I G        E         ++ C+++ +P P+  W K  +G 
Sbjct: 2523 GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK--DGA 2580

Query: 163  PMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSA 209
            P +         I        L I+N Q  ED G+Y C  TN +G A
Sbjct: 2581 PFEASRN-----IQLLPGTHGLQILNAQ-KEDAGQYTCVVTNELGEA 2621



 Score = 41.6 bits (96), Expect = 8e-04
 Identities = 46/184 (25%), Positives = 74/184 (40%), Gaps = 22/184 (11%)

Query: 49   PVTLQCNLTSSSHTLTYSYWTKNGV---ELSATRKNASNMEYRINKPRAEDSGEYHCVYH 105
            PV L+C   +  H      W   G+   E + +R        R+  P    SG Y CV  
Sbjct: 1613 PVALEC--VARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCV-- 1668

Query: 106  FVSAPKANA----TIEVKAAPDITGHKRSENKNE--GQDATMYCKSVGYPHPDWIWRKKE 159
              S+P   A    ++EV+  P +   +         GQ   + C++ G P P   W   +
Sbjct: 1669 -ASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWL--Q 1725

Query: 160  NGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
            NG P +    +G   +      T L+I ++++ +  G + C ATN  G+A     + V  
Sbjct: 1726 NGRPAE--ELAG---VQVASQGTTLHIDHVEL-DHSGLFACQATNEAGTAGAEVEVSVHG 1779

Query: 220  HLAP 223
              AP
Sbjct: 1780 EWAP 1783



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 32/123 (26%), Positives = 54/123 (43%), Gaps = 11/123 (8%)

Query: 88   RINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSE--NKNEGQDATMYCK 144
            ++ + + +DSG Y C+  +     + N ++EV   P I      E     +GQ A + C 
Sbjct: 2409 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 2468

Query: 145  SVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
              G+P P   W K  +G P+      G    I+ +    L ++   ++   G Y C A N
Sbjct: 2469 VTGHPQPKLTWFK--DGRPL----ARGDAHHISPDGVL-LQVLQANLS-SAGHYSCIAAN 2520

Query: 205  AIG 207
            A+G
Sbjct: 2521 AVG 2523



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 45/166 (27%), Positives = 75/166 (45%), Gaps = 16/166 (9%)

Query: 49   PVTLQCNLTS-SSHTLTYSYWTKNG--VELSATRKNASNM-EYRINKPRAEDSGEYHCVY 104
            P+ L C+++   + T+T   W K+   VE SA     S     ++++ +   +G Y CV 
Sbjct: 3141 PLVLTCDVSGVPAPTVT---WLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVA 3197

Query: 105  HFVSAP-KANATIEVKAAPDI--TGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENG 161
                A  + +  + V  AP I  +G  R  +  EGQ+  + C++ G P PD  W K  + 
Sbjct: 3198 ENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSP 3257

Query: 162  MPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIG 207
            +  D +    RF++    +   L +  L+   D G Y C A N  G
Sbjct: 3258 LGQD-MGPHLRFYL----DGGSLVLKGLR-ASDAGAYTCVAHNPAG 3297



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 45/184 (24%), Positives = 73/184 (39%), Gaps = 23/184 (12%)

Query: 45   SPVLPVTLQCNLTSSSH-TLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCV 103
            +P  P+ L C+   +    +T   W K+G  L+    N+          R  D+G Y C+
Sbjct: 3508 TPGAPMELLCDAQGTPQPNIT---WHKDGQALTRLENNSRATRVL----RVRDAGLYTCL 3560

Query: 104  YHF-VSAPKANATIEVKAAPDITGHKRSE---NKNEGQDATMYCKSVGYPHPDWIWRKKE 159
                  A + +  + V+A P+I G +          GQ   + C     P P   W +  
Sbjct: 3561 AESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ-LVLECSVEAEPAPKITWHR-- 3617

Query: 160  NGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
            +G+   ++          +  + +L  ++   T D G+Y C A NA GS SV    RV  
Sbjct: 3618 DGI---VLQEDAHTQFPERGRFLQLQALS---TADSGDYSCTARNAAGSTSV--AFRVEI 3669

Query: 220  HLAP 223
            H  P
Sbjct: 3670 HTVP 3673



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 32/127 (25%), Positives = 51/127 (40%), Gaps = 18/127 (14%)

Query: 95  EDSGEYHC-VYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDW 153
           ED+G Y C   + V   +   T+     P ++          G++A + C++ G P P  
Sbjct: 670 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRV 729

Query: 154 IWRKKENGMPMDIV---NTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSAS 210
           IW +   G+ M +    ++SG+  I   +              D G Y C A N +G AS
Sbjct: 730 IWYR--GGLEMILAPEGSSSGKLRIPAAQE------------RDAGTYTCRAVNELGDAS 775

Query: 211 VVTVLRV 217
               L V
Sbjct: 776 AEIQLAV 782



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 34/127 (26%), Positives = 54/127 (42%), Gaps = 16/127 (12%)

Query: 96   DSGEYHC-VYHFVSAPKANATIEVKAAPDIT--GHKRSENKNEGQDATMYCKSVGYPHPD 152
            DSG+Y C   + V +    A + V   P I   G K + +   GQ  T+ C + G+P P+
Sbjct: 1272 DSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPE 1331

Query: 153  WIWRKKEN--GMPMDIVNTS--------GRFFIINKENYTELNIVNLQITEDPGEYECNA 202
             +W K     G+P+              G   ++++     L+   +Q   D G Y C A
Sbjct: 1332 IVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ--SLHFPRIQ-EGDSGLYSCRA 1388

Query: 203  TNAIGSA 209
             N  G+A
Sbjct: 1389 ENQAGTA 1395



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 36/134 (26%), Positives = 52/134 (38%), Gaps = 15/134 (11%)

Query: 88   RINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSV 146
            +I K    D G Y C   +     K    ++V   P+I     ++   E    T+ C + 
Sbjct: 1851 QIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLAS 1910

Query: 147  GYPHPDWIWRKKENGMPMDI---VNTSGRFFIINKENYTELNIVNLQITEDPGEYECNAT 203
            G P PD  W K    +   +   V+  GR           L I   Q++ D G Y C A+
Sbjct: 1911 GVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------LRIEQAQLS-DAGSYRCVAS 1959

Query: 204  NAIGSASVVTVLRV 217
            N  GS  +   LRV
Sbjct: 1960 NVAGSTELRYGLRV 1973



 Score = 35.8 bits (81), Expect = 0.043
 Identities = 42/204 (20%), Positives = 75/204 (36%), Gaps = 29/204 (14%)

Query: 32   PRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSY--WTKNGVELS---ATRKNASNME 86
            P  +  EE+ +       V L+C     SH +      W K+G  L        +A    
Sbjct: 2070 PPSILGEELNVSVVANESVALECQ----SHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL 2125

Query: 87   YRINKPRAEDSGEYHC-VYHFVSAPKANATIEVKAAPDIT-GHKRSENKNEGQDATMYCK 144
             ++++    D+G Y C   +     + +  + V  AP        +    EG   ++ C+
Sbjct: 2126 LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCE 2185

Query: 145  SVGYPHPDWIWRKKENGMP-----MDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYE 199
              G P P   WRK    +P     +  V+  GR   + +    +            G Y 
Sbjct: 2186 CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQ-----------EGTYT 2234

Query: 200  CNATNAIGSASVVTVLRVRSHLAP 223
            C  +N +G++S    L++  H+ P
Sbjct: 2235 CECSNVVGNSS--QDLQLEVHVPP 2256



 Score = 35.4 bits (80), Expect = 0.057
 Identities = 33/131 (25%), Positives = 53/131 (40%), Gaps = 13/131 (9%)

Query: 93   RAEDSGEYHC-VYHFVSAPKANATIEVKAAPDITGHKRS----ENKNEGQDATMYCKSVG 147
            RAE++G Y C   + V     +  + V   P I G           N     ++ C ++G
Sbjct: 2812 RAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALG 2871

Query: 148  YPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIG 207
             P P   W   +NG+P    + S R  ++      +++   +    D   Y C A N  G
Sbjct: 2872 NPVPTISWL--QNGLPF---SPSPRLQVLEDGQVLQVSTAEVA---DAASYMCVAENQAG 2923

Query: 208  SASVVTVLRVR 218
            SA  +  LRV+
Sbjct: 2924 SAEKLFTLRVQ 2934



 Score = 34.3 bits (77), Expect = 0.13
 Identities = 34/134 (25%), Positives = 50/134 (37%), Gaps = 21/134 (15%)

Query: 88   RINKPRAEDSGEYHCVYHFVSAPKANAT----IEVKAAPDITGHKRSENKNEGQDATMYC 143
            R+ + +  DSG Y C     S P  +A+    + V+  P +    R      G+   + C
Sbjct: 1085 RLAQVQVGDSGHYECT---ASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNC 1141

Query: 144  KSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNAT 203
             + G P P   W K       D V   GR      +       +    T D G Y C A+
Sbjct: 1142 VAEGNPEPQLSWSK-------DGVVLQGR----GPQGSVHFAAIR---TSDAGRYRCEAS 1187

Query: 204  NAIGSASVVTVLRV 217
            N+ G  +    LRV
Sbjct: 1188 NSAGVDAWEVELRV 1201



 Score = 34.3 bits (77), Expect = 0.13
 Identities = 43/200 (21%), Positives = 77/200 (38%), Gaps = 33/200 (16%)

Query: 32   PRIVTSEEVIIRDSPVLPVTLQCNLTS-SSHTLTYSYWTKNGVELSATRKNASNMEYRIN 90
            P  +  ++     + + PV L C+ T   + T++   W+K G +L A         YR++
Sbjct: 3856 PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS---WSKAGAQLGARGSG-----YRVS 3907

Query: 91   KPRAED--------SGEYHC-VYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATM 141
               A +        +G Y C   +       +  + V+A+P +            ++  +
Sbjct: 3908 PSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 3967

Query: 142  YCKSVGYPHPDWIWRKKENGMPMDI---VNTSGRFFIINKENYTELNIVNLQITEDPGEY 198
             C++ G P P   W+K+   +   +   V   G+  I +               ED G Y
Sbjct: 3968 PCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHAS------------PEDAGNY 4015

Query: 199  ECNATNAIGSASVVTVLRVR 218
             C A N+ GSA   T L V+
Sbjct: 4016 LCIAKNSAGSAMGKTRLVVQ 4035



 Score = 33.5 bits (75), Expect = 0.22
 Identities = 39/185 (21%), Positives = 70/185 (37%), Gaps = 17/185 (9%)

Query: 38   EEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNA---SNMEYRINKPRA 94
            EEV +  S    V+LQC   +  + +    W +NG+  S + +          +++    
Sbjct: 2853 EEVTVNASST--VSLQC--PALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEV 2908

Query: 95   EDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSE-NKNEGQDATMYCKSVGYPHPD 152
             D+  Y CV  +   + +   T+ V+  P I G    +         ++ C    +P+P+
Sbjct: 2909 ADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPE 2968

Query: 153  WIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVV 212
              W K    + +         F++   +  +L    L    D G Y C A NA G    +
Sbjct: 2969 VTWYKDSQALSL-----GEEVFLLPGTHTLQLGRARLS---DSGMYTCEALNAAGRDQKL 3020

Query: 213  TVLRV 217
              L V
Sbjct: 3021 VQLSV 3025



 Score = 32.0 bits (71), Expect = 0.63
 Identities = 42/189 (22%), Positives = 73/189 (38%), Gaps = 28/189 (14%)

Query: 32   PRIVTSEEVIIRDSPVLPVTLQCNLTSSSH-TLTYSYWTKNG----VELSATRKNASNME 86
            PR   ++  +++D      TL+CN T     T+T   W ++G     EL    +N     
Sbjct: 2261 PREPPTQVSVVQDGVA---TLECNATGKPPPTVT---WERDGQPVGAELGLQLQN-QGQS 2313

Query: 87   YRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENKNEG---QDATMY 142
              + + +A  +G Y CV  +     +    + V   P++ G                T+ 
Sbjct: 2314 LHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLL 2373

Query: 143  CKSVGYPHPDWIWRKKENGMPM--DIVNTSGRFFIINKENYTELNIVNLQITEDPGEYEC 200
            C+++G P P   W + E  +    D    +G + +  K   T+         +D G Y C
Sbjct: 2374 CEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML--KMTQTQ--------EQDSGLYSC 2423

Query: 201  NATNAIGSA 209
             A+N  G A
Sbjct: 2424 LASNEAGEA 2432



 Score = 31.2 bits (69), Expect = 1.1
 Identities = 16/73 (21%), Positives = 31/73 (42%), Gaps = 8/73 (10%)

Query: 135  EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITED 194
            E   A +YC +   P PD  W +++  +     +      ++      ++ +V     E+
Sbjct: 2764 ENNPAYLYCDTNAIPPPDLTWYREDQPL-----SAGDEVSVLQGGRVLQIPLVR---AEN 2815

Query: 195  PGEYECNATNAIG 207
             G Y C A+N +G
Sbjct: 2816 AGRYSCKASNEVG 2828



 Score = 30.0 bits (66), Expect = 2.4
 Identities = 30/125 (24%), Positives = 47/125 (37%), Gaps = 12/125 (9%)

Query: 89   INKPRAEDSGEYHC-VYHFVSAPKANATIEVKAAPDITGHKRSENK-NEGQD--ATMYCK 144
            + + +    G Y C   + V     +  +EV   P I G +    + +  QD  AT+ C 
Sbjct: 2222 LGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECN 2281

Query: 145  SVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
            + G P P   W +  +G P+      G    +  +N  +   V        G Y C A N
Sbjct: 2282 ATGKPPPTVTWER--DGQPV------GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN 2333

Query: 205  AIGSA 209
              G A
Sbjct: 2334 LAGRA 2338



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 32/144 (22%), Positives = 56/144 (38%), Gaps = 17/144 (11%)

Query: 80  KNASNMEYRINKPRAEDSGEYHCV-YHFVSAPKANATIEVKAAPDITGHKRSENKNEGQD 138
           + + N  + I +    + G Y C         +A A I V   P       +   + G+ 
Sbjct: 474 QESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGET 533

Query: 139 ATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQIT----ED 194
           A + C+ +G    +  W +    +P     ++GR          +L  ++L+I+     D
Sbjct: 534 AVLSCRVLGEAPYNLTWVRDWRVLPA----STGRV--------AQLADLSLEISGIIPTD 581

Query: 195 PGEYECNATNAIGSASVVTVLRVR 218
            G Y+C A+NA G       L VR
Sbjct: 582 GGRYQCVASNANGVTRASVWLLVR 605



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 43/205 (20%), Positives = 74/205 (36%), Gaps = 25/205 (12%)

Query: 26   GAAQNEPRIVTSEEVIIRDS-PVLPVT------LQCNLTSSSH-TLTYSYWTKNGVELSA 77
            G+A  + R+V     +I +  P L  T      L C    S    +T   W K+G  +S 
Sbjct: 4024 GSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT---WDKDGQPVSG 4080

Query: 78   TRKNAS---NMEYRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENK 133
                 +   + E  +     +D+G Y C   + V   +    + +   P  T      + 
Sbjct: 4081 AEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL 4140

Query: 134  NEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITE 193
              G    + C + G P P   W   +  +      T G   +  ++  + L    +   E
Sbjct: 4141 RLGDRLWLRCAARGSPTPRIGWTVNDRPV------TEG---VSEQDGGSTLQRAAVS-RE 4190

Query: 194  DPGEYECNATNAIGSASVVTVLRVR 218
            D G Y C A N +G    V+ + V+
Sbjct: 4191 DSGTYVCWAENRVGRTQAVSFVHVK 4215


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 57/245 (23%), Positives = 105/245 (42%), Gaps = 30/245 (12%)

Query: 36  TSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNG-VELSATRKNASNME-----YRI 89
           T  ++ IR + +    L+C  T   H      W K+G  +  A R+   ++      + I
Sbjct: 604 TPHDITIRTTTM--ARLECAATG--HPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFI 659

Query: 90  NKPRAEDSGEYHCV-YHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGY 148
              + +D+G Y C   +   +  ANAT+ V   P +         + G+   + CK+ G 
Sbjct: 660 TDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGN 719

Query: 149 PHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGS 208
           P P   W K +   P+ +         +  +N  +L +V   + ED G Y C  +N +G+
Sbjct: 720 PPPRITWFKGDR--PLSLTERHH----LTPDN--QLLVVQNVVAEDAGRYTCEMSNTLGT 771

Query: 209 ------ASVVTVLRVRSHLAPLWPF-LGILAEIII--LVVIIVVYEKRKRPDE--VPDDD 257
                  SV+     R     +  F + +++ I++  LV + ++Y+ RK+ +E  V + D
Sbjct: 772 ERAHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTD 831

Query: 258 EPAGP 262
           E   P
Sbjct: 832 ETVVP 836


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 54/189 (28%), Positives = 84/189 (44%), Gaps = 23/189 (12%)

Query: 54  CNLTSSSHT-LTYSYWTKNGVELSATRKNASN--------MEY----RINKPRAEDSGEY 100
           C+  SSS + +T+++   N +   A  +N ++        MEY    R+ +      G+Y
Sbjct: 520 CSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKY 579

Query: 101 HCVY--HFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKK 158
            CV   HF S+    A + V   P  T          G  A + C +VG+P P   W +K
Sbjct: 580 QCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW-QK 638

Query: 159 ENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSAS---VVTVL 215
           + G          R  ++ +++     IV+++I ED G Y C A N+ GS S    +TVL
Sbjct: 639 DGGTDFPAAR-ERRMHVMPEDDV--FFIVDVKI-EDIGVYSCTAQNSAGSISANATLTVL 694

Query: 216 RVRSHLAPL 224
              S L PL
Sbjct: 695 ETPSFLRPL 703



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 52/228 (22%), Positives = 90/228 (39%), Gaps = 37/228 (16%)

Query: 52  LQCNLTSSSHTLTYSYWTKNG-VELSATRKNASNME-----YRINKPRAEDSGEYHCV-Y 104
           L+C   +  H      W K+G  +  A R+   ++      + I   + ED G Y C   
Sbjct: 622 LEC--AAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQ 679

Query: 105 HFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPM 164
           +   +  ANAT+ V   P            +G+ A + C + G P P   W K ++    
Sbjct: 680 NSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDS---- 735

Query: 165 DIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGS------ASVVTVLRVR 218
            +V T   FF        +L I+      D G+Y C  +N +G+       SV+      
Sbjct: 736 PLVVTERHFFAAG----NQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCD 791

Query: 219 S--HLAPL-----WPFLGILAEIII-------LVVIIVVYEKRKRPDE 252
           S    AP      W  +G++   ++       LV ++++Y  R+R ++
Sbjct: 792 SPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNED 839


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 54/189 (28%), Positives = 84/189 (44%), Gaps = 23/189 (12%)

Query: 54  CNLTSSSHT-LTYSYWTKNGVELSATRKNASN--------MEY----RINKPRAEDSGEY 100
           C+  SSS + +T+++   N +   A  +N ++        MEY    R+ +      G+Y
Sbjct: 460 CSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKY 519

Query: 101 HCVY--HFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKK 158
            CV   HF S+    A + V   P  T          G  A + C +VG+P P   W +K
Sbjct: 520 QCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW-QK 578

Query: 159 ENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSAS---VVTVL 215
           + G          R  ++ +++     IV+++I ED G Y C A N+ GS S    +TVL
Sbjct: 579 DGGTDFPAAR-ERRMHVMPEDDV--FFIVDVKI-EDIGVYSCTAQNSAGSISANATLTVL 634

Query: 216 RVRSHLAPL 224
              S L PL
Sbjct: 635 ETPSFLRPL 643



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 52/228 (22%), Positives = 90/228 (39%), Gaps = 37/228 (16%)

Query: 52  LQCNLTSSSHTLTYSYWTKNG-VELSATRKNASNME-----YRINKPRAEDSGEYHCV-Y 104
           L+C   +  H      W K+G  +  A R+   ++      + I   + ED G Y C   
Sbjct: 562 LEC--AAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQ 619

Query: 105 HFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPM 164
           +   +  ANAT+ V   P            +G+ A + C + G P P   W K ++    
Sbjct: 620 NSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDS---- 675

Query: 165 DIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGS------ASVVTVLRVR 218
            +V T   FF        +L I+      D G+Y C  +N +G+       SV+      
Sbjct: 676 PLVVTERHFFAAG----NQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCD 731

Query: 219 S--HLAPL-----WPFLGILAEIII-------LVVIIVVYEKRKRPDE 252
           S    AP      W  +G++   ++       LV ++++Y  R+R ++
Sbjct: 732 SPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNED 779


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score = 55.1 bits (131), Expect = 7e-08
 Identities = 48/163 (29%), Positives = 71/163 (43%), Gaps = 12/163 (7%)

Query: 50   VTLQCNLTSSSHTLTYSYWTKNGVELSATRKNA--SNMEYRINKPRAEDSGEYHCVYHFV 107
            +TL C L + +  +    W KN   L         S+    I + + +D GEY CV   V
Sbjct: 907  LTLPCTLLAGN-PIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNV 965

Query: 108  SAPKANAT-IEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDI 166
            +      T + V   P I   ++  +  EG   T+ CK+ G P P  IW KK      ++
Sbjct: 966  AGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKG-----EL 1020

Query: 167  VNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSA 209
            ++TS   F    +    L +V+    E+ GEY C ATN  G A
Sbjct: 1021 ISTSSAKFSAGADG--SLYVVS-PGGEESGEYVCTATNTAGYA 1060



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 54/205 (26%), Positives = 88/205 (42%), Gaps = 31/205 (15%)

Query: 30   NEPRIVT---SEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNME 86
            +EP ++    SE  +I ++P+L   L C  T +     +  W K G+ ++ + +N + + 
Sbjct: 3985 HEPPVIQPQPSELHVILNNPIL---LPCEATGTPSP--FITWQKEGINVNTSGRNHAVLP 4039

Query: 87   ---YRINKPRAEDSGEYHCV-YHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMY 142
                +I++   ED+G Y CV  +          + V+  P I+ H +       +  T+ 
Sbjct: 4040 SGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLS 4099

Query: 143  CKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQIT----EDPGEY 198
            C++ G P PD  W K             GR  I+       L+  +LQI      D G Y
Sbjct: 4100 CEADGLPPPDITWHK------------DGRA-IVESIRQRVLSSGSLQIAFVQPGDAGHY 4146

Query: 199  ECNATNAIGSASVVTVLRVRSHLAP 223
             C A N  GS+S  T L V  H+ P
Sbjct: 4147 TCMAANVAGSSSTSTKLTV--HVPP 4169



 Score = 52.0 bits (123), Expect = 6e-07
 Identities = 49/208 (23%), Positives = 84/208 (40%), Gaps = 31/208 (14%)

Query: 24  GPGAAQ-----NEPRIVTSEEVIIRDSPVLPVTLQCNLTSS-SHTLTYSYWTKNGVELS- 76
           G G AQ     +EP  V      +  +P     L C + S+  + LT   W +N  ++  
Sbjct: 506 GTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLT---WQRNDRDVRL 562

Query: 77  ---ATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANAT-IEVKAAPDITGHKRSEN 132
              A  +  +N+   +   +  D+GEYHC+        A +  + V+  P +T   ++++
Sbjct: 563 AEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQS 622

Query: 133 KNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQI- 191
              G + ++ C + GYP P   W             T    FI+    Y   +   L I 
Sbjct: 623 FTGGSEVSIMCSATGYPKPKIAW-------------TVNDMFIVGSHRYRMTSDGTLFIK 669

Query: 192 ---TEDPGEYECNATNAIGSASVVTVLR 216
               +D G Y C A+N+ G+    + LR
Sbjct: 670 NAAPKDAGIYGCLASNSAGTDKQNSTLR 697



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 51/179 (28%), Positives = 79/179 (44%), Gaps = 17/179 (9%)

Query: 49   PVTLQCNLTS-SSHTLTYSYWTKNGVEL--SATRKNASNMEYRINKPRAEDSGEYHCVYH 105
            P+TL C         +T   W K+G  +  S  ++  S+   +I   +  D+G Y C+  
Sbjct: 4095 PITLSCEADGLPPPDIT---WHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAA 4151

Query: 106  FVSAPKANAT-IEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPM 164
             V+   + +T + V   P I   +     NE   A + C + G P P   W KK+N +  
Sbjct: 4152 NVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINW-KKDNVL-- 4208

Query: 165  DIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAP 223
             + N  G++     E Y EL + N+ + ED G Y C A NA G  +    L V  H+ P
Sbjct: 4209 -LANLLGKY---TAEPYGELILENV-VLEDSGFYTCVANNAAGEDTHTVSLTV--HVLP 4260



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 40/149 (26%), Positives = 62/149 (41%), Gaps = 5/149 (3%)

Query: 88  RINKPRAEDSGEYHCV-YHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSV 146
           +I + +  D+G+Y CV  +         T++V + P         +   G + T+ C   
Sbjct: 758 KIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQ 817

Query: 147 GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAI 206
           GYP P   WR+ +N   M I +       I++     L I+NL    D G Y C A N  
Sbjct: 818 GYPEPTIKWRRLDN---MPIFSRPFSVSSISQLRTGALFILNLW-ASDKGTYICEAENQF 873

Query: 207 GSASVVTVLRVRSHLAPLWPFLGILAEII 235
           G     T + V   +APL      +A +I
Sbjct: 874 GKIQSETTVTVTGLVAPLIGISPSVANVI 902



 Score = 48.5 bits (114), Expect = 6e-06
 Identities = 46/188 (24%), Positives = 80/188 (42%), Gaps = 21/188 (11%)

Query: 26   GAAQNEPRIVTSE-EVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASN 84
            G  QN   +++   E++ +   + P TL        H L      K G+ +S  R     
Sbjct: 2108 GEEQNVSVLISQAVELLCQSDAIPPPTL--TWLKDGHPLL----KKPGLSISENRS---- 2157

Query: 85   MEYRINKPRAEDSGEYHC-VYHFVSAPKANATIEVKAAPDITGHKRSENKN--EGQDATM 141
               +I   + +D+G Y C   +     + N  + +   P+I G          EG   ++
Sbjct: 2158 -VLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISL 2216

Query: 142  YCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECN 201
             C+S G P P+ IW+KK  G P+ + ++ GR  I++     +++I       D   Y C 
Sbjct: 2217 LCESSGIPPPNLIWKKK--GSPV-LTDSMGRVRILSGGRQLQISIAE---KSDAALYSCV 2270

Query: 202  ATNAIGSA 209
            A+N  G+A
Sbjct: 2271 ASNVAGTA 2278



 Score = 48.5 bits (114), Expect = 6e-06
 Identities = 32/125 (25%), Positives = 54/125 (43%), Gaps = 11/125 (8%)

Query: 95   EDSGEYHCVYHFVSAPKANA-TIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDW 153
            EDSG Y CV +  +    +  ++ V   P  T      + N+G+   + CK+ G P P  
Sbjct: 4232 EDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKL 4291

Query: 154  IWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVT 213
             W    N +P    + +G         ++EL ++     ED G Y C A N++G    + 
Sbjct: 4292 TWTFNNNIIPAHFDSVNG---------HSEL-VIERVSKEDSGTYVCTAENSVGFVKAIG 4341

Query: 214  VLRVR 218
             + V+
Sbjct: 4342 FVYVK 4346



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 40/156 (25%), Positives = 67/156 (42%), Gaps = 12/156 (7%)

Query: 68   WTKNGV--ELSATRKNASNMEYRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDI 124
            W + GV  E+S   +   N    I     ED+G+Y CV  +     + + ++ +++ P I
Sbjct: 4383 WNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPII 4442

Query: 125  TGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTEL 184
            T        N G    + C++ G P P   W ++ + +  D          +N  +   L
Sbjct: 4443 TLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDR--------VNVLSNNSL 4494

Query: 185  NIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSH 220
             I + Q  ED  E+EC A N +GS  V   + V+ H
Sbjct: 4495 YIADAQ-KEDTSEFECVARNLMGSVLVRVPVIVQVH 4529



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 42/159 (26%), Positives = 65/159 (40%), Gaps = 20/159 (12%)

Query: 68   WTKNGVEL---SATRKNASNMEYRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPD 123
            W KNG+ L   S  R  A+    RI + +  D   Y CV  +       +  ++V A P+
Sbjct: 3376 WLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPN 3435

Query: 124  ITGHKRSENKN--EGQDATMYCKSVGYPHPDWIWRKKENGMPMDI---VNTSGRFFIINK 178
            +     +E     +G   +M C + G P P   W +    + +D    V+T G    + K
Sbjct: 3436 MDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLK 3495

Query: 179  ENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRV 217
                         TED G+Y C A+N  G  S   +L+V
Sbjct: 3496 AE-----------TEDSGKYTCIASNEAGEVSKHFILKV 3523



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 50/200 (25%), Positives = 84/200 (42%), Gaps = 26/200 (13%)

Query: 49   PVTLQCNLTS-SSHTLTYSYWTKNGVELSATRKNASNME----YRINKPRAEDSGEYHCV 103
            PV L+C      + +LT   W K+G  +S+       +       +   +  D+G Y CV
Sbjct: 2028 PVRLECEARGIPAPSLT---WLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCV 2084

Query: 104  YHFVSAPKA-NATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGM 162
                +  K  +  + V   P+I G +++ +    Q   + C+S   P P   W K  +G 
Sbjct: 2085 AVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLK--DGH 2142

Query: 163  PMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLA 222
            P  ++   G   +   EN + L I + Q+ +D G Y C ATN  G          +++  
Sbjct: 2143 P--LLKKPG---LSISENRSVLKIEDAQV-QDTGRYTCEATNVAGKTE-------KNYNV 2189

Query: 223  PLW--PFLGILAEIIILVVI 240
             +W  P +G   E+  L VI
Sbjct: 2190 NIWVPPNIGGSDELTQLTVI 2209



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 51/186 (27%), Positives = 76/186 (40%), Gaps = 21/186 (11%)

Query: 27   AAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSAT---RKNAS 83
            A  +EPR +T    ++R+  V   TL+C   S +       W +NG  L AT   R  + 
Sbjct: 3623 AGTDEPRDIT----VLRNRQV---TLECK--SDAVPPPVITWLRNGERLQATPRVRILSG 3673

Query: 84   NMEYRINKPRAEDSGEYHCVYHFVSAPKANATI-EVKAAPDITGHKRSENKNEGQDATMY 142
                +IN     D+  Y CV   ++       I  V   P+I G  +S      +   + 
Sbjct: 3674 GRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLE 3733

Query: 143  CKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNA 202
            C + G P P   WRK        +     R+ I+       L+I +  +T D G Y C A
Sbjct: 3734 CIAEGVPTPRITWRKDG----AVLAGNHARYSILENGF---LHIQSAHVT-DTGRYLCMA 3785

Query: 203  TNAIGS 208
            TNA G+
Sbjct: 3786 TNAAGT 3791



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 46/172 (26%), Positives = 71/172 (41%), Gaps = 26/172 (15%)

Query: 50   VTLQCNLTSSSHTLTYSYWTKNGVELS---ATRKNASNMEYRINKPRAEDSGEYHCVYHF 106
            V+L C   +S   L    W K+G  +S   + R  +     R+ +   ED+G+Y CV   
Sbjct: 2404 VSLTCE--ASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRN 2461

Query: 107  VSAPKANAT-IEVKAAPDITGHKRSENKN--EGQDATMYCKSVGYPHPDWIWRKKENGMP 163
             +  +     + V   P I G    E+    E Q  T+ C+  G P P+  W K  +G P
Sbjct: 2462 AAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHK--DGQP 2519

Query: 164  MD-----IVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSAS 210
            +       + + GRF          L I N+Q+    G Y C A++  G  S
Sbjct: 2520 LQEDEAHHIISGGRF----------LQITNVQVPH-TGRYTCLASSPAGHKS 2560



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 50/198 (25%), Positives = 81/198 (40%), Gaps = 24/198 (12%)

Query: 32   PRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRI-- 89
            P I   E  +I ++   PVTL C+ T          W KN   +    +N+ ++E RI  
Sbjct: 3151 PSIEGPEREVIVETISNPVTLTCDATGIPPPTIA--WLKNHKRI----ENSDSLEVRILS 3204

Query: 90   -------NKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENKNE--GQDA 139
                    + +  DSG Y C+  +     +    + ++  P + G +   + +   G++ 
Sbjct: 3205 GGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENV 3264

Query: 140  TMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYE 199
             + C + G P P   W K  +G P+    T     I    N + LNI    +T D G+Y 
Sbjct: 3265 ELVCNANGIPTPLIQWLK--DGKPIASGETER---IRVSANGSTLNIYGA-LTSDTGKYT 3318

Query: 200  CNATNAIGSASVVTVLRV 217
            C ATN  G    +  L V
Sbjct: 3319 CVATNPAGEEDRIFNLNV 3336



 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 47/189 (24%), Positives = 76/189 (40%), Gaps = 26/189 (13%)

Query: 48   LPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNAS---NMEYRINKPRAEDSGEYHCVY 104
            +PVTL C   +S +      W+K G  +S +    S   +    +  P  E+SGEY C  
Sbjct: 996  IPVTLPCK--ASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTA 1053

Query: 105  -HFVSAPKANATIEVKAAPDITGHKRSENKNE--------GQDATMYCKSVGYPHPDWIW 155
             +     K    + V   P + G +R  ++++        G++ T+ C+    P P   W
Sbjct: 1054 TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 1113

Query: 156  RKKENGM-PMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTV 214
             K+   + P    +T   F        TE        T D G Y C ATN  G  +V   
Sbjct: 1114 AKETQLISPFSPRHT---FLPSGSMKITETR------TSDSGMYLCVATNIAG--NVTQA 1162

Query: 215  LRVRSHLAP 223
            +++  H+ P
Sbjct: 1163 VKLNVHVPP 1171



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 33/144 (22%), Positives = 58/144 (40%), Gaps = 10/144 (6%)

Query: 68   WTKNGVELSATRKNASNME---YRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPD 123
            W K+G  L+      S +E     I      D+G Y C+  +     +    ++V   P 
Sbjct: 3746 WRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPS 3805

Query: 124  ITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTE 183
            I     +         T+ C++ G P P   WRK  NG  +++      + +++  +   
Sbjct: 3806 IAPGPTNMTVIVNVQTTLACEATGIPKPSINWRK--NGHLLNVDQNQNSYRLLSSGS--- 3860

Query: 184  LNIVNLQITEDPGEYECNATNAIG 207
            L I++  + +D   YEC  TN  G
Sbjct: 3861 LVIISPSV-DDTATYECTVTNGAG 3883



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 47/196 (23%), Positives = 73/196 (37%), Gaps = 17/196 (8%)

Query: 32   PRIVTSEEVIIRDSPVL-------PVTLQCNLTS-SSHTLTYSYWTKNGVELSATRKNAS 83
            PR+   +  + +D PV         VTL C + S     +T++  T+     S       
Sbjct: 1072 PRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLP 1131

Query: 84   NMEYRINKPRAEDSGEYHCVYHFVSAPKANAT-IEVKAAPDITGHKRSENKNEGQDATMY 142
            +   +I + R  DSG Y CV   ++     A  + V   P I    +      GQ   + 
Sbjct: 1132 SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIP 1191

Query: 143  CKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNA 202
            C + G P P   W K  + M +D     G   + N +    ++        D G Y C A
Sbjct: 1192 CNAQGTPLPVITWSKGGSTMLVD-----GEHHVSNPDGTLSIDQAT---PSDAGIYTCVA 1243

Query: 203  TNAIGSASVVTVLRVR 218
            TN  G+      L V+
Sbjct: 1244 TNIAGTDETEITLHVQ 1259



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 47/196 (23%), Positives = 76/196 (38%), Gaps = 20/196 (10%)

Query: 31   EPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSAT---RKNASNMEY 87
            EP  +   E     S ++   L+    +S        W K+G  L  T   +        
Sbjct: 3525 EPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVL 3584

Query: 88   RINKPRAEDSGEYHCVYHFVSAPKAN----ATIEVKAAPDITG--HKRSENKNEGQDATM 141
            RI+  + ED+G Y C+    S+P  +      + V   P+I G    R       +  T+
Sbjct: 3585 RISTAQVEDTGRYTCL---ASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTL 3641

Query: 142  YCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECN 201
             CKS   P P   W +  NG   + +  + R  I++   Y ++N  +L    D   Y C 
Sbjct: 3642 ECKSDAVPPPVITWLR--NG---ERLQATPRVRILSGGRYLQINNADL---GDTANYTCV 3693

Query: 202  ATNAIGSASVVTVLRV 217
            A+N  G  +   +L V
Sbjct: 3694 ASNIAGKTTREFILTV 3709



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 41/193 (21%), Positives = 83/193 (43%), Gaps = 15/193 (7%)

Query: 68   WTKNGVEL--SATRKNASNMEY-RINKPRAEDSGEYHC-VYHFVSAPKANATIEVKAAPD 123
            W K+ V++  S+T +  +N +  ++ +   ED+G Y C   +     +    I+V   P 
Sbjct: 1394 WYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPT 1453

Query: 124  ITGHKRSENKNE--GQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENY 181
            I G       +    +D  + C+  G P PD  W K  +G P+ + + +        +  
Sbjct: 1454 IIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFK--DGKPLFLGDPNVELL----DRG 1507

Query: 182  TELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVII 241
              L++ N +   D G Y+C  +NA G  +    +++  ++ P      +  +I +L+  +
Sbjct: 1508 QVLHLKNAR-RNDKGRYQCTVSNAAGKQA--KDIKLTIYIPPSIKGGNVTTDISVLINSL 1564

Query: 242  VVYEKRKRPDEVP 254
            +  E   R   +P
Sbjct: 1565 IKLECETRGLPMP 1577



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 45/179 (25%), Positives = 69/179 (38%), Gaps = 25/179 (13%)

Query: 49   PVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNA---SNMEYRINKPRAEDSGEYHCV-Y 104
            PV L+C   ++ + +    W K+   LS +             I   +  D+G Y CV  
Sbjct: 1937 PVQLECK--AAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAI 1994

Query: 105  HFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPM 164
            +   A +   +++V  AP I+G              + C++ G P P   W K  +G P+
Sbjct: 1995 NSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLK--DGSPV 2052

Query: 165  DI------VNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRV 217
                    V + GR           L + + QI+ D G Y C A NA G       LRV
Sbjct: 2053 SSFSNGLQVLSGGRI----------LALTSAQIS-DTGRYTCVAVNAAGEKQRDIDLRV 2100



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 38/127 (29%), Positives = 56/127 (44%), Gaps = 14/127 (11%)

Query: 96   DSGEYHCV-YHFVSAPKANATIEVKAAPDITGHKRS-ENKN--EGQDATMYCKSVGYPHP 151
            D+G Y CV  +          + V A P I G+ RS EN +  E    ++ C++ G P P
Sbjct: 2357 DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLP 2416

Query: 152  DWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQIT-EDPGEYECNATNAIGSAS 210
               W K  +G P+ + N+     I++      L    +Q T ED G+Y C   NA G   
Sbjct: 2417 SITWFK--DGWPVSLSNSVR---ILSGGRMLRL----MQTTMEDAGQYTCVVRNAAGEER 2467

Query: 211  VVTVLRV 217
             +  L V
Sbjct: 2468 KIFGLSV 2474



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 51/193 (26%), Positives = 79/193 (40%), Gaps = 30/193 (15%)

Query: 26   GAAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSAT--RKNAS 83
            GA  + P  VT   V++  S ++    +C   SS      + W K+G  L      K  S
Sbjct: 2873 GANSDLPEEVT---VLVNKSALI----EC--LSSGSPAPRNSWQKDGQPLLEDDHHKFLS 2923

Query: 84   NMEY-RINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENKNE--GQDA 139
            N    +I   +  D G Y CV  +   + K    + V   P + G K SEN         
Sbjct: 2924 NGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK-SENLTVVVNNFI 2982

Query: 140  TMYCKSVGYPHPDWIWRKKENGMPMD---IVNTSGRFFIINKENYTELNIVNLQITEDPG 196
            ++ C+  G+P PD  W K E  + ++   ++   GR           L I+  +++ D G
Sbjct: 2983 SLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGR----------TLQIIRAKVS-DGG 3031

Query: 197  EYECNATNAIGSA 209
            EY C A N  G +
Sbjct: 3032 EYTCIAINQAGES 3044



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 41/157 (26%), Positives = 63/157 (40%), Gaps = 15/157 (9%)

Query: 68  WTKNGVELSATRKN--ASNMEYRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDI 124
           WT N + +  + +    S+    I     +D+G Y C+  +     K N+T+    AP +
Sbjct: 645 WTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKL 704

Query: 125 TGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTEL 184
              +       G    M CK+ G P P   W K       D+      F II+      L
Sbjct: 705 MVVQSELLVALGDITVMECKTSGIPPPQVKWFKG------DLELRPSTFLIID----PLL 754

Query: 185 NIVNLQITE--DPGEYECNATNAIGSASVVTVLRVRS 219
            ++ +Q T+  D G+Y C A N  G A+    L V S
Sbjct: 755 GLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGS 791



 Score = 37.0 bits (84), Expect = 0.019
 Identities = 33/125 (26%), Positives = 52/125 (41%), Gaps = 13/125 (10%)

Query: 88   RINKPRAEDSGEYHCV-YHFVSAPKANATIEVKAAPDITGHKRSE----NKNEGQDATMY 142
            +I + +  D GEY C+  +     K   ++ V   P I  H        N  EG   ++ 
Sbjct: 3021 QIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLE 3080

Query: 143  CKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNA 202
            C+S   P P   W K  NG    ++  S    I+   +   L+I   +++ D G+Y C A
Sbjct: 3081 CESNAVPPPVITWYK--NGR---MITESTHVEIL--ADGQMLHIKKAEVS-DTGQYVCRA 3132

Query: 203  TNAIG 207
             N  G
Sbjct: 3133 INVAG 3137



 Score = 36.6 bits (83), Expect = 0.025
 Identities = 54/210 (25%), Positives = 72/210 (34%), Gaps = 36/210 (17%)

Query: 17   VSGSLLPGPGAAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELS 76
            V  S+ PGP          T+  VI+     +  TL C  T          W KNG  L+
Sbjct: 3802 VPPSIAPGP----------TNMTVIVN----VQTTLACEATGIPKPSIN--WRKNGHLLN 3845

Query: 77   ATRKNASNMEYR--------INKPRAEDSGEYHC-VYHFVSAPKANATIEVKAAPDITGH 127
              +   S   YR        I  P  +D+  Y C V +     K    + V+  P I   
Sbjct: 3846 VDQNQNS---YRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADE 3902

Query: 128  KRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIV 187
                   +   A + C + G P P   W K  NG+ +      G  + I      E+   
Sbjct: 3903 PTDFLVTKHAPAVITCTASGVPFPSIHWTK--NGIRL---LPRGDGYRILSSGAIEILAT 3957

Query: 188  NLQITEDPGEYECNATNAIGSASVVTVLRV 217
             L      G Y C A NA GSA     L V
Sbjct: 3958 QLN---HAGRYTCVARNAAGSAHRHVTLHV 3984



 Score = 36.2 bits (82), Expect = 0.033
 Identities = 38/149 (25%), Positives = 56/149 (37%), Gaps = 15/149 (10%)

Query: 68   WTKNGVELSATRKNASNME----YRINKPRAEDSGEYHCV-YHFVSAPKANATIEVKAAP 122
            W  NG EL+      S +E      I      D+GEY CV  +     +    ++V   P
Sbjct: 1300 WLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPP 1359

Query: 123  DITGHKRSENKNE--GQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
             I   ++  N +    Q   ++C+  G P P  +W K       D V  +    I    N
Sbjct: 1360 VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK-------DNVQVTESSTIQTVNN 1412

Query: 181  YTELNIVNLQITEDPGEYECNATNAIGSA 209
               L +      ED G Y C A N  G++
Sbjct: 1413 GKILKLFRAT-PEDAGRYSCKAINIAGTS 1440



 Score = 35.8 bits (81), Expect = 0.043
 Identities = 52/221 (23%), Positives = 81/221 (36%), Gaps = 42/221 (19%)

Query: 52   LQCNLTSSSHTLTYSYWTKNGV---ELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVS 108
            L C++T S        W K+G    E    +   +  +  I + +  ++G Y C+     
Sbjct: 1754 LDCHVTGSPPPTIM--WLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCM----- 1806

Query: 109  APKANATIEVKAAPDITGHKRSENKNEG---------QDATMYCKSVGYPHPDWIWRKKE 159
               AN   + K   ++T H     K+ G         +   + C + G P+P   W K +
Sbjct: 1807 --AANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDD 1864

Query: 160  NGMPMDI------VNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVT 213
               P++       + +SGR   I K            + ED G Y C ATNA G      
Sbjct: 1865 Q--PVNTAQGNLKIQSSGRVLQIAKT-----------LLEDAGRYTCVATNAAGETQQHI 1911

Query: 214  VLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVP 254
             L V  H  P     G +    +LV   V  E +   + VP
Sbjct: 1912 QLHV--HEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVP 1950



 Score = 35.4 bits (80), Expect = 0.057
 Identities = 47/211 (22%), Positives = 86/211 (40%), Gaps = 38/211 (18%)

Query: 24   GPGAAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTS-SSHTLTYSYWTKNGVELSA---TR 79
            GPG +  E +I  +  +          TL+C   +  S +L+   W K+G  L +     
Sbjct: 2676 GPGLSPKEVKIKVNNTL----------TLECEAYAIPSASLS---WYKDGQPLKSDDHVN 2722

Query: 80   KNASNMEYRINKPRAEDSGEYHCVYHFVSAP-KANATIEVKAAPDIT-----GHKRSENK 133
              A+    +I + +  D+G Y CV   ++   + +  + ++  P        G+     +
Sbjct: 2723 IAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGR 2782

Query: 134  N-EGQDA------TMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNI 186
            N E +D       ++YC++   P P   W K  +G P+    +S +  I+      ++  
Sbjct: 2783 NGEAKDVIINNPISLYCETNAAPPPTLTWYK--DGHPL---TSSDKVLILPGGRVLQIPR 2837

Query: 187  VNLQITEDPGEYECNATNAIGSASVVTVLRV 217
              +   ED G Y C A N  G  S+   +RV
Sbjct: 2838 AKV---EDAGRYTCVAVNEAGEDSLQYDVRV 2865



 Score = 35.0 bits (79), Expect = 0.074
 Identities = 39/151 (25%), Positives = 68/151 (45%), Gaps = 15/151 (9%)

Query: 68   WTKNGVEL-SATRKNASNMEYRINKPRAE--DSGEYHC-VYHFVSAPKANATIEVKAAPD 123
            W K+G  + S+++    +    ++ PRA+  DS  Y C V +     + +  ++V   P 
Sbjct: 1581 WYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPM 1640

Query: 124  ITGHKRSENKNE---GQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
            I G+  +    +       T+ CK+ G P P   W K  +G+P+   N + R     K  
Sbjct: 1641 IEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLK--DGVPVK-ANDNIRIEAGGK-- 1695

Query: 181  YTELNIVNLQITEDPGEYECNATNAIGSASV 211
              +L I++ Q   D G+Y C AT+  G   +
Sbjct: 1696 --KLEIMSAQ-EIDRGQYICVATSVAGEKEI 1723



 Score = 32.0 bits (71), Expect = 0.63
 Identities = 36/134 (26%), Positives = 53/134 (39%), Gaps = 15/134 (11%)

Query: 94  AEDSGEYHC-VYHFVSAPKANATIEVKA--APDITGHKRSENKNEGQDATMYCKSV-GYP 149
           A D G Y C   +     ++  T+ V    AP I       N  EGQ  T+ C  + G P
Sbjct: 859 ASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNP 918

Query: 150 HPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSA 209
            P+  W K    +          +  +  +    +  V LQ   D GEY C A+N  G+ 
Sbjct: 919 IPERRWIKNSAML------LQNPYITVRSDGSLHIERVQLQ---DGGEYTCVASNVAGTN 969

Query: 210 SVVTVLRVRSHLAP 223
           +  T + V  H+ P
Sbjct: 970 NKTTSVVV--HVLP 981



 Score = 31.2 bits (69), Expect = 1.1
 Identities = 33/155 (21%), Positives = 59/155 (38%), Gaps = 12/155 (7%)

Query: 68  WTKNGVELSATR--KNASNMEYRINKPRAEDSGEYHCV-YHFVSAPKANATIEVKAAPDI 124
           + +NGV L   +  K ++++   I K    D G Y C+        +A    +V   P +
Sbjct: 463 FVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPV 522

Query: 125 TGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYT-E 183
                +     G+ A + C  +     +  W++ +       V  +    I    N + E
Sbjct: 523 IQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRD-----VRLAEPARIRTLANLSLE 577

Query: 184 LNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
           L  V      D GEY C  ++  GS++    L V+
Sbjct: 578 LKSVKFN---DAGEYHCMVSSEGGSSAASVFLTVQ 609


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score = 55.1 bits (131), Expect = 7e-08
 Identities = 47/182 (25%), Positives = 78/182 (42%), Gaps = 17/182 (9%)

Query: 39  EVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTK-NGVELSATRKNASNMEYRINKPRAEDS 97
           EV+I  S     TL+C  T   H L    WT+ NG+EL  +R  A++    +      D 
Sbjct: 340 EVLIGTS----TTLECMATGHPHPLIT--WTRDNGLELDGSRHVATSSGLYLQNITQRDH 393

Query: 98  GEYHC-VYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWR 156
           G + C   +     +A A I V+A P  T   + +   E       C++ G P P  +W 
Sbjct: 394 GRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWT 453

Query: 157 KKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLR 216
           K    +P++     G+  +++         ++     D G+YEC A +++G   V   L 
Sbjct: 454 KTGGQLPVE-----GQHTVLSSGTLR----IDRAAQHDQGQYECQAVSSLGVKKVSVQLT 504

Query: 217 VR 218
           V+
Sbjct: 505 VK 506



 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 43/192 (22%), Positives = 76/192 (39%), Gaps = 25/192 (13%)

Query: 34  IVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYS-----------YWTKNGVELSATRKNA 82
           +  +  +I++  P   VT +  +    H + +             WTK G +L    ++ 
Sbjct: 407 VQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHT 466

Query: 83  --SNMEYRINKPRAEDSGEYHCVYHF---VSAPKANATIEVKAAPDITGHKRSENKNEGQ 137
             S+   RI++    D G+Y C       V       T++ KA    T   +  +   G+
Sbjct: 467 VLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGK 526

Query: 138 DATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGE 197
           +  + C + G P P   W K+  G+    +  SG+F + ++   T  +        D G 
Sbjct: 527 NINISCHAQGEPQPIITWNKE--GVQ---ITESGKFHVDDEGTLTIYDAG----FPDQGR 577

Query: 198 YECNATNAIGSA 209
           YEC A N+ G A
Sbjct: 578 YECVARNSFGLA 589



 Score = 30.4 bits (67), Expect = 1.8
 Identities = 24/102 (23%), Positives = 39/102 (38%), Gaps = 21/102 (20%)

Query: 121 APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
           +P IT   +      G      C++ G P P+ IW    + + +              E+
Sbjct: 233 SPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDL--------------ED 278

Query: 181 YTELNIVN---LQI----TEDPGEYECNATNAIGSASVVTVL 215
            T LN+ +   L I      D G Y+C A N+ G A   + +
Sbjct: 279 DTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAM 320


>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
           sapiens]
          Length = 1386

 Score = 54.7 bits (130), Expect = 9e-08
 Identities = 47/185 (25%), Positives = 78/185 (42%), Gaps = 14/185 (7%)

Query: 39  EVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNA-SNMEYRINKPRAEDS 97
           +V++ D+PV   T  C +           W K   EL   R    S+    I    AED 
Sbjct: 267 QVVLADAPV---TFLCEVKGDPPPRLR--WRKEDGELPTGRYEIRSDHSLWIGHVSAEDE 321

Query: 98  GEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWR 156
           G Y CV  + V   +A+ ++ V   P +    + +    G+     C++ G P P   W+
Sbjct: 322 GTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQ 381

Query: 157 KKENGM---PMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVT 213
           K+ + +   P   +  +GRF +  +    +LNI  +Q   D G Y C A +  GS     
Sbjct: 382 KEGSQVLLFPSQSLQPTGRFSVSPR---GQLNITAVQ-RGDAGYYVCQAVSVAGSILAKA 437

Query: 214 VLRVR 218
           +L ++
Sbjct: 438 LLEIK 442



 Score = 30.4 bits (67), Expect = 1.8
 Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 5/80 (6%)

Query: 134 NEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVN---TSGRFFIINKENYTELNIVNLQ 190
           + G+ AT+ C++ G P P+  W K  NG  +  V     + R  + +   +    +   +
Sbjct: 76  SRGEPATLPCRAEGRPRPNIEWYK--NGARVATVREDPRAHRLLLPSGALFFPRIVHGRR 133

Query: 191 ITEDPGEYECNATNAIGSAS 210
              D G Y C A N +G+A+
Sbjct: 134 ARPDEGVYTCVARNYLGAAA 153



 Score = 29.6 bits (65), Expect = 3.1
 Identities = 32/134 (23%), Positives = 51/134 (38%), Gaps = 23/134 (17%)

Query: 96  DSGEYHCVYHFVSAP-KANATIEVKAA------PDITGHKRSENKNEGQDATMYCKSVGY 148
           D+G Y C    V+    A A +E+K A      P I     ++    G    + C+  G 
Sbjct: 418 DAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGN 477

Query: 149 PHPDWIWRKKENGMPMDIVN----TSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
           P P   W+K    +  D +      +G  +I N +              D G Y C A +
Sbjct: 478 PQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEM------------DMGFYSCVAKS 525

Query: 205 AIGSASVVTVLRVR 218
           + G A+    L++R
Sbjct: 526 STGEATWSGWLKMR 539


>gi|45594240 limbic system-associated membrane protein [Homo
           sapiens]
          Length = 338

 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 44/135 (32%), Positives = 59/135 (43%), Gaps = 18/135 (13%)

Query: 84  NMEY--RINKPRAEDSGEYHCVYHFVSAPKANAT-IEVKAAPDITGHKRSENKNEGQDAT 140
           ++EY  RI K    D G Y C       PK +   + V+  P I+        NEG + T
Sbjct: 91  SLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVT 150

Query: 141 MYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQIT-EDPGEYE 199
           + C + G P P   WR          +  +GR F   +E Y E+    L IT E  G+YE
Sbjct: 151 LVCMANGRPEPVITWRH---------LTPTGREF-EGEEEYLEI----LGITREQSGKYE 196

Query: 200 CNATNAIGSASVVTV 214
           C A N + SA V  V
Sbjct: 197 CKAANEVSSADVKQV 211



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 34/123 (27%), Positives = 54/123 (43%), Gaps = 9/123 (7%)

Query: 95  EDSGEYHC--VYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPD 152
           E SG+Y C       SA      + V   P IT  K +E    G+ A++ C++   P PD
Sbjct: 190 EQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNE-ATTGRQASLKCEASAVPAPD 248

Query: 153 WIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVV 212
           + W + +       +N++    I + E  + L + N+   E  G Y C A N +G  +  
Sbjct: 249 FEWYRDDTR-----INSANGLEIKSTEGQSSLTVTNV-TEEHYGNYTCVAANKLGVTNAS 302

Query: 213 TVL 215
            VL
Sbjct: 303 LVL 305


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 45/160 (28%), Positives = 66/160 (41%), Gaps = 9/160 (5%)

Query: 68  WTKNGVELSATRKNA-SNMEYRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDIT 125
           W K+  EL  +R     +   +I K  A D G Y CV  + V   +A+AT+ V+  P   
Sbjct: 256 WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315

Query: 126 GHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENG---MPMDIVNTSGRFFIINKENYT 182
              R +    G+  T  C++ G P P   WR++ +           +S RF +       
Sbjct: 316 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV---SQTG 372

Query: 183 ELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLA 222
           +L I N+Q   D G Y C   N  GS      L V   +A
Sbjct: 373 DLTITNVQ-RSDVGYYICQTLNVAGSIITKAYLEVTDVIA 411



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 45/174 (25%), Positives = 68/174 (39%), Gaps = 15/174 (8%)

Query: 49  PVTLQCNLTSSSHTLTYSYWTKNGVELSAT--RKNASNMEYRINKPRAEDSGEYHCVYHF 106
           P  ++C         T S W K+G  L     R      +  I   R  D+G+Y CV   
Sbjct: 147 PAVMECQPPRGHPEPTIS-WKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTN 205

Query: 107 VSAPKANATIEVKAAPDITGHKRSENKNEGQD--ATMYCKSVGYPHPDWIWRKKENGMPM 164
           +   + +   E+      +  KR  N     D  A   C++ G P P   WRK +  +P 
Sbjct: 206 MVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP- 264

Query: 165 DIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
                  R+ I  ++++T L I  +    D G Y C A N +G A     L V+
Sbjct: 265 -----KSRYEI--RDDHT-LKIRKV-TAGDMGSYTCVAENMVGKAEASATLTVQ 309



 Score = 34.7 bits (78), Expect = 0.097
 Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 1/89 (1%)

Query: 122 PDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENY 181
           P I  H      ++G+ AT+ CK+ G P P   W K    +  D  +      ++   + 
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 182 TELNIVN-LQITEDPGEYECNATNAIGSA 209
             L IV+  +   D G Y C A N +G A
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEA 117



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 41/196 (20%), Positives = 74/196 (37%), Gaps = 31/196 (15%)

Query: 50  VTLQCNLTSSSHTLTYSYWTKNGVE---------LSATRKNASNM-EYRINKPRAEDSGE 99
           VT QC  T +     +  W + G +          S++R + S   +  I   +  D G 
Sbjct: 329 VTFQCEATGNPQPAIF--WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 386

Query: 100 YHC-----VYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDAT--MYCKSVGYPHPD 152
           Y C         ++      T  +   P     +   N+    D T  + C + G P P 
Sbjct: 387 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 446

Query: 153 WIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITE--DPGEYECNATNAIGSAS 210
            +WRK  +G+   +V+T       ++    E  ++ ++  +  D G Y C A+   G A+
Sbjct: 447 ILWRK--DGV---LVSTQD-----SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 496

Query: 211 VVTVLRVRSHLAPLWP 226
               + V+    P+ P
Sbjct: 497 WSAYIEVQEFGVPVQP 512


>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
           sapiens]
          Length = 790

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 45/185 (24%), Positives = 79/185 (42%), Gaps = 25/185 (13%)

Query: 32  PRIVTSEEVIIRDSPVLPVTLQCN-LTSSSHTLTYSYWTKNGVELSATRKNAS---NMEY 87
           P++V +  V +  SP     L C  L  + + LT   W ++   L A+    +   ++  
Sbjct: 517 PQLVPAPNVTV--SPGETAVLSCRVLGEAPYNLT---WVRDWRVLPASTGRVAQLADLSL 571

Query: 88  RINKPRAEDSGEYHCVYHFVSA-PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSV 146
            I+     D G Y CV    +   +A+  + V+ AP ++ H  S++ ++G +  + C + 
Sbjct: 572 EISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSAS 631

Query: 147 GYPHPDWIWRKKENGMPMDI---VNTSGRFFIINKENYTELNIVNLQITEDPGEYECNAT 203
           GYP P   W ++   +  D    V+  G              I+     ED G Y C AT
Sbjct: 632 GYPTPHISWSRESQALQEDSRIHVDAQGTL------------IIQGVAPEDAGNYSCQAT 679

Query: 204 NAIGS 208
           N +G+
Sbjct: 680 NEVGT 684



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 32/127 (25%), Positives = 51/127 (40%), Gaps = 18/127 (14%)

Query: 95  EDSGEYHC-VYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDW 153
           ED+G Y C   + V   +   T+     P ++          G++A + C++ G P P  
Sbjct: 669 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRV 728

Query: 154 IWRKKENGMPMDIV---NTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSAS 210
           IW +   G+ M +    ++SG+  I   +              D G Y C A N +G AS
Sbjct: 729 IWYR--GGLEMILAPEGSSSGKLRIPAAQE------------RDAGTYTCRAVNELGDAS 774

Query: 211 VVTVLRV 217
               L V
Sbjct: 775 AEIQLAV 781



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 32/144 (22%), Positives = 56/144 (38%), Gaps = 17/144 (11%)

Query: 80  KNASNMEYRINKPRAEDSGEYHCV-YHFVSAPKANATIEVKAAPDITGHKRSENKNEGQD 138
           + + N  + I +    + G Y C         +A A I V   P       +   + G+ 
Sbjct: 473 QESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGET 532

Query: 139 ATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQIT----ED 194
           A + C+ +G    +  W +    +P     ++GR          +L  ++L+I+     D
Sbjct: 533 AVLSCRVLGEAPYNLTWVRDWRVLPA----STGRV--------AQLADLSLEISGIIPTD 580

Query: 195 PGEYECNATNAIGSASVVTVLRVR 218
            G Y+C A+NA G       L VR
Sbjct: 581 GGRYQCVASNANGVTRASVWLLVR 604


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 45/160 (28%), Positives = 66/160 (41%), Gaps = 9/160 (5%)

Query: 68  WTKNGVELSATRKNA-SNMEYRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDIT 125
           W K+  EL  +R     +   +I K  A D G Y CV  + V   +A+AT+ V+  P   
Sbjct: 295 WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 354

Query: 126 GHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENG---MPMDIVNTSGRFFIINKENYT 182
              R +    G+  T  C++ G P P   WR++ +           +S RF +       
Sbjct: 355 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV---SQTG 411

Query: 183 ELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLA 222
           +L I N+Q   D G Y C   N  GS      L V   +A
Sbjct: 412 DLTITNVQ-RSDVGYYICQTLNVAGSIITKAYLEVTDVIA 450



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 45/174 (25%), Positives = 68/174 (39%), Gaps = 15/174 (8%)

Query: 49  PVTLQCNLTSSSHTLTYSYWTKNGVELSAT--RKNASNMEYRINKPRAEDSGEYHCVYHF 106
           P  ++C         T S W K+G  L     R      +  I   R  D+G+Y CV   
Sbjct: 186 PAVMECQPPRGHPEPTIS-WKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTN 244

Query: 107 VSAPKANATIEVKAAPDITGHKRSENKNEGQD--ATMYCKSVGYPHPDWIWRKKENGMPM 164
           +   + +   E+      +  KR  N     D  A   C++ G P P   WRK +  +P 
Sbjct: 245 MVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP- 303

Query: 165 DIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
                  R+ I  ++++T L I  +    D G Y C A N +G A     L V+
Sbjct: 304 -----KSRYEI--RDDHT-LKIRKV-TAGDMGSYTCVAENMVGKAEASATLTVQ 348



 Score = 34.7 bits (78), Expect = 0.097
 Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 1/89 (1%)

Query: 122 PDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENY 181
           P I  H      ++G+ AT+ CK+ G P P   W K    +  D  +      ++   + 
Sbjct: 68  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127

Query: 182 TELNIVN-LQITEDPGEYECNATNAIGSA 209
             L IV+  +   D G Y C A N +G A
Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEA 156



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 41/196 (20%), Positives = 74/196 (37%), Gaps = 31/196 (15%)

Query: 50  VTLQCNLTSSSHTLTYSYWTKNGVE---------LSATRKNASNM-EYRINKPRAEDSGE 99
           VT QC  T +     +  W + G +          S++R + S   +  I   +  D G 
Sbjct: 368 VTFQCEATGNPQPAIF--WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 425

Query: 100 YHC-----VYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDAT--MYCKSVGYPHPD 152
           Y C         ++      T  +   P     +   N+    D T  + C + G P P 
Sbjct: 426 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 485

Query: 153 WIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITE--DPGEYECNATNAIGSAS 210
            +WRK  +G+   +V+T       ++    E  ++ ++  +  D G Y C A+   G A+
Sbjct: 486 ILWRK--DGV---LVSTQD-----SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 535

Query: 211 VVTVLRVRSHLAPLWP 226
               + V+    P+ P
Sbjct: 536 WSAYIEVQEFGVPVQP 551


>gi|134244585 putative neuronal cell adhesion molecule [Homo
           sapiens]
          Length = 814

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 64/214 (29%), Positives = 86/214 (40%), Gaps = 39/214 (18%)

Query: 10  LALSLLLVSGSLLPGPG-----AAQNEPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLT 64
           L L LLL+   LLP P      +A+    +  S++V +   P  P+ L C +  +     
Sbjct: 20  LLLPLLLL---LLPAPSEGLGHSAELAFAVEPSDDVAV---PGQPIVLDCRVEGTPPVRI 73

Query: 65  YSYWTKNGVELSATRKNA--SNMEYRINKPRAE------DSGEYHCVYH--FVSAPKANA 114
              W KNGVEL  +  +   +N    I   R E      D G+Y CV    F       A
Sbjct: 74  T--WRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKA 131

Query: 115 TIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFF 174
            I+     D   H ++    EG  A   C+  G P P   W K  N +P+D  N      
Sbjct: 132 RIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEK--NRVPIDTDN------ 183

Query: 175 IINKENYTELNIVNLQIT----EDPGEYECNATN 204
               E YT L    LQIT    ED G + C A+N
Sbjct: 184 ----ERYTLLPKGVLQITGLRAEDGGIFHCVASN 213



 Score = 36.6 bits (83), Expect = 0.025
 Identities = 30/106 (28%), Positives = 46/106 (43%), Gaps = 8/106 (7%)

Query: 112 ANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSG 171
           A   + V+A  +   H +S ++  G  A   C++ G P P   W K  NG    ++   G
Sbjct: 320 AQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLK--NG---QVLGPGG 374

Query: 172 RFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRV 217
              +  K N + L I  +   ED   Y+C A N+ GS+     L V
Sbjct: 375 HVRL--KNNNSTLTISGIG-PEDEAIYQCVAENSAGSSQASARLTV 417


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 46/160 (28%), Positives = 67/160 (41%), Gaps = 16/160 (10%)

Query: 68    WTKNGVELSATRK-----NASNMEYRINKPRAEDSGEYHCVYHF---VSAPKANATI--E 117
             W  NGVEL+ + +     + S+    I +    D G   C+      +   + + T+  E
Sbjct: 26765 WVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKE 26824

Query: 118   VKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIIN 177
             +  AP      RS+N NEGQ+    C+  G P P+  W K  N +P+ I   S    I  
Sbjct: 26825 LSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFK--NNLPISI---SSNVSISR 26879

Query: 178   KENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRV 217
               N   L I N  ++ D G+Y   A N  G  S    L V
Sbjct: 26880 SRNVYSLEIRNASVS-DSGKYTIKAKNFRGQCSATASLMV 26918



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 35/160 (21%), Positives = 67/160 (41%), Gaps = 14/160 (8%)

Query: 68    WTKNGVELSATRKNASNMEYR-----INKPRAEDSGEYHCVY-HFVSAPKANATIEVKAA 121
             W + G EL  +RK   + + R     +     ED G Y C+  + V   + ++ + ++A 
Sbjct: 24261 WYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQAT 24320

Query: 122   PDI-TGHKRSENKNEGQDATM--YCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINK 178
             P    G+   E       +T+  +   +G P P   W   +      ++  S    I N 
Sbjct: 24321 PQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQK-----LLQNSENITIENT 24375

Query: 179   ENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
             E+YT L + N+Q     G+Y+   +N  G+   +  + ++
Sbjct: 24376 EHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQ 24415



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 27/110 (24%), Positives = 46/110 (41%), Gaps = 15/110 (13%)

Query: 114 ATIEVKAAPD-ITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKK----ENGMPMDIVN 168
           A +E+   P  +    ++    EG+  T+ C   GYP P   W ++    E+ +   I  
Sbjct: 888 APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 947

Query: 169 TSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
            SG   ++ +E +           ED G + C+A N  G+ S    L V+
Sbjct: 948 QSGIARLMIREAF----------AEDSGRFTCSAVNEAGTVSTSCYLAVQ 987



 Score = 37.7 bits (86), Expect = 0.011
 Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 4/86 (4%)

Query: 134   NEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITE 193
             +EG+  T+ C   G P P+  W     G         GRF I N ++ T L I+++Q  +
Sbjct: 27036 DEGKVLTVACAFTGEPTPEVTW---SCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQ-KQ 27091

Query: 194   DPGEYECNATNAIGSASVVTVLRVRS 219
             D G Y  +  N  GS S    + +RS
Sbjct: 27092 DGGLYTLSLGNEFGSDSATVNIHIRS 27117



 Score = 37.0 bits (84), Expect = 0.019
 Identities = 25/99 (25%), Positives = 41/99 (41%), Gaps = 6/99 (6%)

Query: 121   APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
             AP I    +      G+ A + C+ VG P PD  W +    +         R + ++ + 
Sbjct: 24227 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKEL------IQSRKYKMSSDG 24280

Query: 181   YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
              T    V  +  ED G Y C ATN +G     + L +++
Sbjct: 24281 RTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQA 24319



 Score = 36.6 bits (83), Expect = 0.025
 Identities = 39/133 (29%), Positives = 53/133 (39%), Gaps = 10/133 (7%)

Query: 89   INKPRAED-SGEYHCVYHFVS---APKANATIEVKAAPDITGHKRSENKNEGQDATMYCK 144
            I+K   ED  GEY C     S   A  A  T+  +AAP I           G  A   C+
Sbjct: 4492 IDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCE 4551

Query: 145  SVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
                P+  + W K         +  S +  I + +  + L I+  Q+  D GEY C A+N
Sbjct: 4552 IQSAPNVRFQWFKAGRE-----IYESDKCSIRSSKYISSLEILRTQVV-DCGEYTCKASN 4605

Query: 205  AIGSASVVTVLRV 217
              GS S    L V
Sbjct: 4606 EYGSVSCTATLTV 4618



 Score = 35.4 bits (80), Expect = 0.057
 Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 7/108 (6%)

Query: 110   PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNT 169
             PK++  I+   AP      R+ N     +AT+ CK  G+P P   W ++   +  D +  
Sbjct: 24614 PKSDVPIQ---APHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKY 24670

Query: 170   SGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRV 217
               + F   K  Y +L I ++   +D   Y+  ATN  GS S    L V
Sbjct: 24671 RIQEF---KGGYHQLIIASV-TDDDATVYQVRATNQGGSVSGTASLEV 24714



 Score = 34.7 bits (78), Expect = 0.097
 Identities = 24/85 (28%), Positives = 37/85 (43%), Gaps = 5/85 (5%)

Query: 135  EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITED 194
            EGQ A    K VG P P+  W      +  D  +      ++ KE+ T+  I+      D
Sbjct: 1424 EGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHK-----VVIKEDGTQSLIIVPATPSD 1478

Query: 195  PGEYECNATNAIGSASVVTVLRVRS 219
             GE+   A N  G +S+  +L V +
Sbjct: 1479 SGEWTVVAQNRAGRSSISVILTVEA 1503



 Score = 34.7 bits (78), Expect = 0.097
 Identities = 39/155 (25%), Positives = 64/155 (41%), Gaps = 33/155 (21%)

Query: 68   WTKNGVELSATRKNASNMEYRIN-------KPRAEDSGEYHCVYHFVSAPK-ANATIEVK 119
            W +N + +    K+    E +I+       KPR  D GEY     F++  K A A +E+ 
Sbjct: 6639 WLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPR--DQGEYR----FIAKDKEARAKLELA 6692

Query: 120  AAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTS--------- 170
            AAP I    +    + G+  TM      YP  +  W K+   +    ++T+         
Sbjct: 6693 AAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDTTAEQTSFRIL 6752

Query: 171  -------GRFFII--NKENYTELNIVNLQITEDPG 196
                   GR+ I+  NK    E   +NL++ + PG
Sbjct: 6753 EAKKGDKGRYKIVLQNKHGKAE-GFINLKVIDVPG 6786



 Score = 33.1 bits (74), Expect = 0.28
 Identities = 26/83 (31%), Positives = 35/83 (42%), Gaps = 5/83 (6%)

Query: 135  EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITED 194
            +G  A      VG P P   W K+   +      TS  + II+  N +   IVN    ED
Sbjct: 3780 QGLPAIFEYTVVGEPAPTVTWFKENKQLC-----TSVYYTIIHNPNGSGTFIVNDPQRED 3834

Query: 195  PGEYECNATNAIGSASVVTVLRV 217
             G Y C A N +G ++    L V
Sbjct: 3835 SGLYICKAENMLGESTCAAELLV 3857



 Score = 32.3 bits (72), Expect = 0.48
 Identities = 30/145 (20%), Positives = 57/145 (39%), Gaps = 10/145 (6%)

Query: 74    ELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENK 133
             +++ TR++ S+ E+  +      + E   +    +  K   T+  +    I    RS   
Sbjct: 26212 QMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAAR----ILTKPRSMTV 26267

Query: 134   NEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITE 193
              EG+ A   C + G P P   W +K       +++TS R  +   +  +   I ++Q   
Sbjct: 26268 YEGESARFSCDTDGEPVPTVTWLRKG-----QVLSTSARHQVTTTKYKSTFEISSVQ-AS 26321

Query: 194   DPGEYECNATNAIGSASVVTVLRVR 218
             D G Y     N+ G       L ++
Sbjct: 26322 DEGNYSVVVENSEGKQEAEFTLTIQ 26346



 Score = 31.6 bits (70), Expect = 0.82
 Identities = 27/89 (30%), Positives = 39/89 (43%), Gaps = 7/89 (7%)

Query: 119  KAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINK 178
            K  PDI  +       EG+ A   C+  GYP P   W    NG    ++  S R F +  
Sbjct: 1792 KQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYL--NG---QLIRKSKR-FRVRY 1845

Query: 179  ENYTELNIVNLQITEDPGEYECNATNAIG 207
            +    L+IV+ + + D GE +  A N  G
Sbjct: 1846 DGIHYLDIVDCK-SYDTGEVKVTAENPEG 1873



 Score = 31.6 bits (70), Expect = 0.82
 Identities = 27/84 (32%), Positives = 38/84 (45%), Gaps = 7/84 (8%)

Query: 135   EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKE-NYTELNIVNLQITE 193
             EGQ      +  G P P   W K  +G P+ +        II++  +Y  L+I +  + E
Sbjct: 25503 EGQSVCFEIRVSGIPPPTLKWEK--DGQPLSL---GPNIEIIHEGLDYYALHIRDT-LPE 25556

Query: 194   DPGEYECNATNAIGSASVVTVLRV 217
             D G Y   ATN  GS S    L+V
Sbjct: 25557 DTGYYRVTATNTAGSTSCQAHLQV 25580



 Score = 31.2 bits (69), Expect = 1.1
 Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 8/80 (10%)

Query: 136   GQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQIT-ED 194
             G+D  +     G P P   WRK E  +  D      R+ I N ++ + L I   Q+T  D
Sbjct: 20981 GEDVQVLIPFKGRPPPTVTWRKDEKNLGSD-----ARYSIENTDSSSLLTIP--QVTRND 21033

Query: 195   PGEYECNATNAIGSASVVTV 214
              G+Y     N +G     TV
Sbjct: 21034 TGKYILTIENGVGEPKSSTV 21053



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 26/99 (26%), Positives = 43/99 (43%), Gaps = 5/99 (5%)

Query: 121  APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
            AP I    +S+   +G DA    + VG P P+  W K  NG+ ++   +   ++   ++N
Sbjct: 2031 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYK--NGVKIE--RSDRIYWYWPEDN 2086

Query: 181  YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
              EL ++     ED       A N  G  S    L V++
Sbjct: 2087 VCEL-VIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA 2124



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 39/162 (24%), Positives = 68/162 (41%), Gaps = 16/162 (9%)

Query: 60   SHTLTYSYWTKNGVELSATRKNASNMEYRINK-----PRAEDSGEYHCVYHFVSAPKANA 114
            SH    S W KNGVE+  + K    ++ ++++        EDS EY  V       + +A
Sbjct: 2860 SHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFV---CGNDQVSA 2916

Query: 115  TIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFF 174
            T+ V   P +      +   E +D   +  +V Y    + W K  NG+    + ++ +  
Sbjct: 2917 TLTV--TPIMITSMLKDINAEEKDTITFEVTVNYEGISYKWLK--NGVE---IKSTDKCQ 2969

Query: 175  IINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLR 216
            +  K+    LNI N+    D  +Y   A  A  +A++    R
Sbjct: 2970 MRTKKLTHSLNIRNVHF-GDAADYTFVAGKATSTATLYVEAR 3010



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 42/179 (23%), Positives = 66/179 (36%), Gaps = 38/179 (21%)

Query: 51    TLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYH--------- 101
             TL C +T   H      W + G E+ A       ++YRI     E  G YH         
Sbjct: 24641 TLVCKVTG--HPKPIVKWYRQGKEIIA-----DGLKYRIQ----EFKGGYHQLIIASVTD 24689

Query: 102   ---CVYHFVSAPKAN-----ATIEVKAAPDITGHKRSENKN-----EGQDATMYCKSVGY 148
                 VY   +  +       A++EV+    I   K  E         G+  ++     G 
Sbjct: 24690 DDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGK 24749

Query: 149   PHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIG 207
             P P   W+K +     D+++ +G + +I   ++T L   N    +D G Y   A N  G
Sbjct: 24750 PDPVITWQKGQ-----DLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFG 24803



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 27/110 (24%), Positives = 42/110 (38%), Gaps = 8/110 (7%)

Query: 110   PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNT 169
             PKA   I  K  P I    +    +    A    K+ G P P  IW K    +      T
Sbjct: 26537 PKAPEPISSK--PVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI------T 26588

Query: 170   SGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
              G  + ++++       ++   T D G Y C   N+ GS S    L +++
Sbjct: 26589 QGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKA 26638



 Score = 30.4 bits (67), Expect = 1.8
 Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 7/62 (11%)

Query: 147  GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAI 206
            G P P  +W K+E  +  D      R  I N    +EL I+   + +D G Y   ATN+ 
Sbjct: 8825 GRPVPTKVWTKEEGELDKD------RVVIDNVGTKSEL-IIKDALRKDHGRYVITATNSC 8877

Query: 207  GS 208
            GS
Sbjct: 8878 GS 8879



 Score = 29.6 bits (65), Expect = 3.1
 Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 6/99 (6%)

Query: 120 AAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKE 179
           A P+     +S    +G    +  +  G P P  + +   +G  +     S   F I++E
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTP--VVKFYRDGAEIQ----SSLDFQISQE 155

Query: 180 NYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
                 ++     ED G Y  NATN++G A+    L V+
Sbjct: 156 GDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 22/75 (29%), Positives = 32/75 (42%), Gaps = 5/75 (6%)

Query: 135  EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITED 194
            EG   T +CK  GYP P   W K  +G  +         F+ +      + +V   + ED
Sbjct: 1258 EGMGVTFHCKMSGYPLPKIAWYK--DGKRIKHGERYQMDFLQDGRASLRIPVV---LPED 1312

Query: 195  PGEYECNATNAIGSA 209
             G Y   A+N  G+A
Sbjct: 1313 EGIYTAFASNIKGNA 1327



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 17/71 (23%), Positives = 30/71 (42%), Gaps = 6/71 (8%)

Query: 147   GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAI 206
             G P P   W    + +  D        + +  +N++ +  +   +  D GEY+   +NA 
Sbjct: 11231 GVPVPTAKWTTDGSEIKTD------EHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAA 11284

Query: 207   GSASVVTVLRV 217
             GS +V   L V
Sbjct: 11285 GSKTVAVHLTV 11295



 Score = 28.9 bits (63), Expect = 5.3
 Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 6/62 (9%)

Query: 147   GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAI 206
             G PHP   W+K E+    ++V +S     ++K + + + I+     +D G Y   A N+ 
Sbjct: 12619 GKPHPTCKWKKGED----EVVTSS--HLAVHKADSSSILIIKDVTRKDSGYYSLTAENSS 12672

Query: 207   GS 208
             G+
Sbjct: 12673 GT 12674



 Score = 28.5 bits (62), Expect = 6.9
 Identities = 28/103 (27%), Positives = 41/103 (39%), Gaps = 4/103 (3%)

Query: 121 APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
           AP  T   +S    EG  AT      G+P P+  W +  +G  +      G   I   + 
Sbjct: 5   APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFR--DGQVISTSTLPG-VQISFSDG 61

Query: 181 YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAP 223
             +L I  +    + G Y   ATN  G A+    L V++  AP
Sbjct: 62  RAKLTIPAVT-KANSGRYSLKATNGSGQATSTAELLVKAETAP 103



 Score = 28.1 bits (61), Expect = 9.0
 Identities = 18/71 (25%), Positives = 29/71 (40%), Gaps = 6/71 (8%)

Query: 96   DSGEYHCVYH------FVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYP 149
            DSGE+  V         +S       +E +  P      ++ N  EG    M  ++ G P
Sbjct: 1478 DSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNP 1537

Query: 150  HPDWIWRKKEN 160
            +PD +W K  +
Sbjct: 1538 NPDIVWLKNSD 1548



 Score = 28.1 bits (61), Expect = 9.0
 Identities = 21/64 (32%), Positives = 30/64 (46%), Gaps = 4/64 (6%)

Query: 147  GYPHPDWIWRKKENGM--PMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
            G P P   W K E  +  P D +  + +  +   E  TEL+I    + ED G Y   A+N
Sbjct: 9119 GLPMPKIEWSKNETVIEKPTDALQIT-KEEVSRSEAKTELSIPKA-VREDKGTYTVTASN 9176

Query: 205  AIGS 208
             +GS
Sbjct: 9177 RLGS 9180


>gi|110349713 titin isoform novex-1 [Homo sapiens]
          Length = 27051

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 46/160 (28%), Positives = 67/160 (41%), Gaps = 16/160 (10%)

Query: 68    WTKNGVELSATRK-----NASNMEYRINKPRAEDSGEYHCVYHF---VSAPKANATI--E 117
             W  NGVEL+ + +     + S+    I +    D G   C+      +   + + T+  E
Sbjct: 26698 WVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKE 26757

Query: 118   VKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIIN 177
             +  AP      RS+N NEGQ+    C+  G P P+  W K  N +P+ I   S    I  
Sbjct: 26758 LSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFK--NNLPISI---SSNVSISR 26812

Query: 178   KENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRV 217
               N   L I N  ++ D G+Y   A N  G  S    L V
Sbjct: 26813 SRNVYSLEIRNASVS-DSGKYTIKAKNFRGQCSATASLMV 26851



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 35/160 (21%), Positives = 67/160 (41%), Gaps = 14/160 (8%)

Query: 68    WTKNGVELSATRKNASNMEYR-----INKPRAEDSGEYHCVY-HFVSAPKANATIEVKAA 121
             W + G EL  +RK   + + R     +     ED G Y C+  + V   + ++ + ++A 
Sbjct: 24194 WYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQAT 24253

Query: 122   PDI-TGHKRSENKNEGQDATM--YCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINK 178
             P    G+   E       +T+  +   +G P P   W   +      ++  S    I N 
Sbjct: 24254 PQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQK-----LLQNSENITIENT 24308

Query: 179   ENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
             E+YT L + N+Q     G+Y+   +N  G+   +  + ++
Sbjct: 24309 EHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQ 24348



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 27/110 (24%), Positives = 46/110 (41%), Gaps = 15/110 (13%)

Query: 114 ATIEVKAAPD-ITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKK----ENGMPMDIVN 168
           A +E+   P  +    ++    EG+  T+ C   GYP P   W ++    E+ +   I  
Sbjct: 888 APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 947

Query: 169 TSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
            SG   ++ +E +           ED G + C+A N  G+ S    L V+
Sbjct: 948 QSGIARLMIREAF----------AEDSGRFTCSAVNEAGTVSTSCYLAVQ 987



 Score = 37.7 bits (86), Expect = 0.011
 Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 4/86 (4%)

Query: 134   NEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITE 193
             +EG+  T+ C   G P P+  W     G         GRF I N ++ T L I+++Q  +
Sbjct: 26969 DEGKVLTVACAFTGEPTPEVTW---SCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQ-KQ 27024

Query: 194   DPGEYECNATNAIGSASVVTVLRVRS 219
             D G Y  +  N  GS S    + +RS
Sbjct: 27025 DGGLYTLSLGNEFGSDSATVNIHIRS 27050



 Score = 37.0 bits (84), Expect = 0.019
 Identities = 25/99 (25%), Positives = 41/99 (41%), Gaps = 6/99 (6%)

Query: 121   APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
             AP I    +      G+ A + C+ VG P PD  W +    +         R + ++ + 
Sbjct: 24160 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKEL------IQSRKYKMSSDG 24213

Query: 181   YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
              T    V  +  ED G Y C ATN +G     + L +++
Sbjct: 24214 RTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQA 24252



 Score = 36.6 bits (83), Expect = 0.025
 Identities = 39/133 (29%), Positives = 53/133 (39%), Gaps = 10/133 (7%)

Query: 89   INKPRAED-SGEYHCVYHFVS---APKANATIEVKAAPDITGHKRSENKNEGQDATMYCK 144
            I+K   ED  GEY C     S   A  A  T+  +AAP I           G  A   C+
Sbjct: 4425 IDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCE 4484

Query: 145  SVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
                P+  + W K         +  S +  I + +  + L I+  Q+  D GEY C A+N
Sbjct: 4485 IQSAPNVRFQWFKAGRE-----IYESDKCSIRSSKYISSLEILRTQVV-DCGEYTCKASN 4538

Query: 205  AIGSASVVTVLRV 217
              GS S    L V
Sbjct: 4539 EYGSVSCTATLTV 4551



 Score = 35.4 bits (80), Expect = 0.057
 Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 7/108 (6%)

Query: 110   PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNT 169
             PK++  I+   AP      R+ N     +AT+ CK  G+P P   W ++   +  D +  
Sbjct: 24547 PKSDVPIQ---APHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKY 24603

Query: 170   SGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRV 217
               + F   K  Y +L I ++   +D   Y+  ATN  GS S    L V
Sbjct: 24604 RIQEF---KGGYHQLIIASV-TDDDATVYQVRATNQGGSVSGTASLEV 24647



 Score = 34.7 bits (78), Expect = 0.097
 Identities = 24/85 (28%), Positives = 37/85 (43%), Gaps = 5/85 (5%)

Query: 135  EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITED 194
            EGQ A    K VG P P+  W      +  D  +      ++ KE+ T+  I+      D
Sbjct: 1424 EGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHK-----VVIKEDGTQSLIIVPATPSD 1478

Query: 195  PGEYECNATNAIGSASVVTVLRVRS 219
             GE+   A N  G +S+  +L V +
Sbjct: 1479 SGEWTVVAQNRAGRSSISVILTVEA 1503



 Score = 34.7 bits (78), Expect = 0.097
 Identities = 39/155 (25%), Positives = 64/155 (41%), Gaps = 33/155 (21%)

Query: 68   WTKNGVELSATRKNASNMEYRIN-------KPRAEDSGEYHCVYHFVSAPK-ANATIEVK 119
            W +N + +    K+    E +I+       KPR  D GEY     F++  K A A +E+ 
Sbjct: 6572 WLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPR--DQGEYR----FIAKDKEARAKLELA 6625

Query: 120  AAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTS--------- 170
            AAP I    +    + G+  TM      YP  +  W K+   +    ++T+         
Sbjct: 6626 AAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDTTAEQTSFRIL 6685

Query: 171  -------GRFFII--NKENYTELNIVNLQITEDPG 196
                   GR+ I+  NK    E   +NL++ + PG
Sbjct: 6686 EAKKGDKGRYKIVLQNKHGKAE-GFINLKVIDVPG 6719



 Score = 33.1 bits (74), Expect = 0.28
 Identities = 26/83 (31%), Positives = 35/83 (42%), Gaps = 5/83 (6%)

Query: 135  EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITED 194
            +G  A      VG P P   W K+   +      TS  + II+  N +   IVN    ED
Sbjct: 3713 QGLPAIFEYTVVGEPAPTVTWFKENKQLC-----TSVYYTIIHNPNGSGTFIVNDPQRED 3767

Query: 195  PGEYECNATNAIGSASVVTVLRV 217
             G Y C A N +G ++    L V
Sbjct: 3768 SGLYICKAENMLGESTCAAELLV 3790



 Score = 32.3 bits (72), Expect = 0.48
 Identities = 30/145 (20%), Positives = 57/145 (39%), Gaps = 10/145 (6%)

Query: 74    ELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENK 133
             +++ TR++ S+ E+  +      + E   +    +  K   T+  +    I    RS   
Sbjct: 26145 QMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAAR----ILTKPRSMTV 26200

Query: 134   NEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITE 193
              EG+ A   C + G P P   W +K       +++TS R  +   +  +   I ++Q   
Sbjct: 26201 YEGESARFSCDTDGEPVPTVTWLRKG-----QVLSTSARHQVTTTKYKSTFEISSVQ-AS 26254

Query: 194   DPGEYECNATNAIGSASVVTVLRVR 218
             D G Y     N+ G       L ++
Sbjct: 26255 DEGNYSVVVENSEGKQEAEFTLTIQ 26279



 Score = 31.6 bits (70), Expect = 0.82
 Identities = 27/89 (30%), Positives = 39/89 (43%), Gaps = 7/89 (7%)

Query: 119  KAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINK 178
            K  PDI  +       EG+ A   C+  GYP P   W    NG    ++  S R F +  
Sbjct: 1792 KQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYL--NG---QLIRKSKR-FRVRY 1845

Query: 179  ENYTELNIVNLQITEDPGEYECNATNAIG 207
            +    L+IV+ + + D GE +  A N  G
Sbjct: 1846 DGIHYLDIVDCK-SYDTGEVKVTAENPEG 1873



 Score = 31.6 bits (70), Expect = 0.82
 Identities = 27/84 (32%), Positives = 38/84 (45%), Gaps = 7/84 (8%)

Query: 135   EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKE-NYTELNIVNLQITE 193
             EGQ      +  G P P   W K  +G P+ +        II++  +Y  L+I +  + E
Sbjct: 25436 EGQSVCFEIRVSGIPPPTLKWEK--DGQPLSL---GPNIEIIHEGLDYYALHIRDT-LPE 25489

Query: 194   DPGEYECNATNAIGSASVVTVLRV 217
             D G Y   ATN  GS S    L+V
Sbjct: 25490 DTGYYRVTATNTAGSTSCQAHLQV 25513



 Score = 31.2 bits (69), Expect = 1.1
 Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 8/80 (10%)

Query: 136   GQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQIT-ED 194
             G+D  +     G P P   WRK E  +  D      R+ I N ++ + L I   Q+T  D
Sbjct: 20914 GEDVQVLIPFKGRPPPTVTWRKDEKNLGSD-----ARYSIENTDSSSLLTIP--QVTRND 20966

Query: 195   PGEYECNATNAIGSASVVTV 214
              G+Y     N +G     TV
Sbjct: 20967 TGKYILTIENGVGEPKSSTV 20986



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 26/99 (26%), Positives = 43/99 (43%), Gaps = 5/99 (5%)

Query: 121  APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
            AP I    +S+   +G DA    + VG P P+  W K  NG+ ++   +   ++   ++N
Sbjct: 2031 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYK--NGVKIE--RSDRIYWYWPEDN 2086

Query: 181  YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
              EL ++     ED       A N  G  S    L V++
Sbjct: 2087 VCEL-VIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA 2124



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 39/162 (24%), Positives = 68/162 (41%), Gaps = 16/162 (9%)

Query: 60   SHTLTYSYWTKNGVELSATRKNASNMEYRINK-----PRAEDSGEYHCVYHFVSAPKANA 114
            SH    S W KNGVE+  + K    ++ ++++        EDS EY  V       + +A
Sbjct: 2860 SHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFV---CGNDQVSA 2916

Query: 115  TIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFF 174
            T+ V   P +      +   E +D   +  +V Y    + W K  NG+    + ++ +  
Sbjct: 2917 TLTV--TPIMITSMLKDINAEEKDTITFEVTVNYEGISYKWLK--NGVE---IKSTDKCQ 2969

Query: 175  IINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLR 216
            +  K+    LNI N+    D  +Y   A  A  +A++    R
Sbjct: 2970 MRTKKLTHSLNIRNVHF-GDAADYTFVAGKATSTATLYVEAR 3010



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 42/179 (23%), Positives = 66/179 (36%), Gaps = 38/179 (21%)

Query: 51    TLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYH--------- 101
             TL C +T   H      W + G E+ A       ++YRI     E  G YH         
Sbjct: 24574 TLVCKVTG--HPKPIVKWYRQGKEIIA-----DGLKYRIQ----EFKGGYHQLIIASVTD 24622

Query: 102   ---CVYHFVSAPKAN-----ATIEVKAAPDITGHKRSENKN-----EGQDATMYCKSVGY 148
                 VY   +  +       A++EV+    I   K  E         G+  ++     G 
Sbjct: 24623 DDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGK 24682

Query: 149   PHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIG 207
             P P   W+K +     D+++ +G + +I   ++T L   N    +D G Y   A N  G
Sbjct: 24683 PDPVITWQKGQ-----DLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFG 24736



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 27/110 (24%), Positives = 42/110 (38%), Gaps = 8/110 (7%)

Query: 110   PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNT 169
             PKA   I  K  P I    +    +    A    K+ G P P  IW K    +      T
Sbjct: 26470 PKAPEPISSK--PVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI------T 26521

Query: 170   SGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
              G  + ++++       ++   T D G Y C   N+ GS S    L +++
Sbjct: 26522 QGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKA 26571



 Score = 30.4 bits (67), Expect = 1.8
 Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 7/62 (11%)

Query: 147  GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAI 206
            G P P  +W K+E  +  D      R  I N    +EL I+   + +D G Y   ATN+ 
Sbjct: 8758 GRPVPTKVWTKEEGELDKD------RVVIDNVGTKSEL-IIKDALRKDHGRYVITATNSC 8810

Query: 207  GS 208
            GS
Sbjct: 8811 GS 8812



 Score = 30.0 bits (66), Expect = 2.4
 Identities = 19/84 (22%), Positives = 33/84 (39%), Gaps = 4/84 (4%)

Query: 134  NEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITE 193
            + G+    + +  G P P+  W   +      I+ T    F   +     L ++    +E
Sbjct: 3431 HNGETVRFHARVSGIPKPEIQWFHNQQL----ILPTKDVVFHFEESTGMALMLIVDAYSE 3486

Query: 194  DPGEYECNATNAIGSASVVTVLRV 217
              G+Y C A N+ G A+    L V
Sbjct: 3487 HAGQYSCKAANSAGEATCAATLTV 3510



 Score = 29.6 bits (65), Expect = 3.1
 Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 6/99 (6%)

Query: 120 AAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKE 179
           A P+     +S    +G    +  +  G P P  + +   +G  +     S   F I++E
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTP--VVKFYRDGAEIQ----SSLDFQISQE 155

Query: 180 NYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
                 ++     ED G Y  NATN++G A+    L V+
Sbjct: 156 GDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 22/75 (29%), Positives = 32/75 (42%), Gaps = 5/75 (6%)

Query: 135  EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITED 194
            EG   T +CK  GYP P   W K  +G  +         F+ +      + +V   + ED
Sbjct: 1258 EGMGVTFHCKMSGYPLPKIAWYK--DGKRIKHGERYQMDFLQDGRASLRIPVV---LPED 1312

Query: 195  PGEYECNATNAIGSA 209
             G Y   A+N  G+A
Sbjct: 1313 EGIYTAFASNIKGNA 1327



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 17/71 (23%), Positives = 30/71 (42%), Gaps = 6/71 (8%)

Query: 147   GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAI 206
             G P P   W    + +  D        + +  +N++ +  +   +  D GEY+   +NA 
Sbjct: 11164 GVPVPTAKWTTDGSEIKTD------EHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAA 11217

Query: 207   GSASVVTVLRV 217
             GS +V   L V
Sbjct: 11218 GSKTVAVHLTV 11228



 Score = 28.9 bits (63), Expect = 5.3
 Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 6/62 (9%)

Query: 147   GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAI 206
             G PHP   W+K E+    ++V +S     ++K + + + I+     +D G Y   A N+ 
Sbjct: 12552 GKPHPTCKWKKGED----EVVTSS--HLAVHKADSSSILIIKDVTRKDSGYYSLTAENSS 12605

Query: 207   GS 208
             G+
Sbjct: 12606 GT 12607



 Score = 28.5 bits (62), Expect = 6.9
 Identities = 28/103 (27%), Positives = 41/103 (39%), Gaps = 4/103 (3%)

Query: 121 APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
           AP  T   +S    EG  AT      G+P P+  W +  +G  +      G   I   + 
Sbjct: 5   APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFR--DGQVISTSTLPG-VQISFSDG 61

Query: 181 YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAP 223
             +L I  +    + G Y   ATN  G A+    L V++  AP
Sbjct: 62  RAKLTIPAVT-KANSGRYSLKATNGSGQATSTAELLVKAETAP 103



 Score = 28.1 bits (61), Expect = 9.0
 Identities = 18/71 (25%), Positives = 29/71 (40%), Gaps = 6/71 (8%)

Query: 96   DSGEYHCVYH------FVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYP 149
            DSGE+  V         +S       +E +  P      ++ N  EG    M  ++ G P
Sbjct: 1478 DSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNP 1537

Query: 150  HPDWIWRKKEN 160
            +PD +W K  +
Sbjct: 1538 NPDIVWLKNSD 1548



 Score = 28.1 bits (61), Expect = 9.0
 Identities = 21/64 (32%), Positives = 30/64 (46%), Gaps = 4/64 (6%)

Query: 147  GYPHPDWIWRKKENGM--PMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
            G P P   W K E  +  P D +  + +  +   E  TEL+I    + ED G Y   A+N
Sbjct: 9052 GLPMPKIEWSKNETVIEKPTDALQIT-KEEVSRSEAKTELSIPKA-VREDKGTYTVTASN 9109

Query: 205  AIGS 208
             +GS
Sbjct: 9110 RLGS 9113


>gi|110349715 titin isoform N2-B [Homo sapiens]
          Length = 26926

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 46/160 (28%), Positives = 67/160 (41%), Gaps = 16/160 (10%)

Query: 68    WTKNGVELSATRK-----NASNMEYRINKPRAEDSGEYHCVYHF---VSAPKANATI--E 117
             W  NGVEL+ + +     + S+    I +    D G   C+      +   + + T+  E
Sbjct: 26573 WVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKE 26632

Query: 118   VKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIIN 177
             +  AP      RS+N NEGQ+    C+  G P P+  W K  N +P+ I   S    I  
Sbjct: 26633 LSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFK--NNLPISI---SSNVSISR 26687

Query: 178   KENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRV 217
               N   L I N  ++ D G+Y   A N  G  S    L V
Sbjct: 26688 SRNVYSLEIRNASVS-DSGKYTIKAKNFRGQCSATASLMV 26726



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 35/160 (21%), Positives = 67/160 (41%), Gaps = 14/160 (8%)

Query: 68    WTKNGVELSATRKNASNMEYR-----INKPRAEDSGEYHCVY-HFVSAPKANATIEVKAA 121
             W + G EL  +RK   + + R     +     ED G Y C+  + V   + ++ + ++A 
Sbjct: 24069 WYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQAT 24128

Query: 122   PDI-TGHKRSENKNEGQDATM--YCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINK 178
             P    G+   E       +T+  +   +G P P   W   +      ++  S    I N 
Sbjct: 24129 PQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQK-----LLQNSENITIENT 24183

Query: 179   ENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
             E+YT L + N+Q     G+Y+   +N  G+   +  + ++
Sbjct: 24184 EHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQ 24223



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 27/110 (24%), Positives = 46/110 (41%), Gaps = 15/110 (13%)

Query: 114 ATIEVKAAPD-ITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKK----ENGMPMDIVN 168
           A +E+   P  +    ++    EG+  T+ C   GYP P   W ++    E+ +   I  
Sbjct: 888 APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 947

Query: 169 TSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
            SG   ++ +E +           ED G + C+A N  G+ S    L V+
Sbjct: 948 QSGIARLMIREAF----------AEDSGRFTCSAVNEAGTVSTSCYLAVQ 987



 Score = 37.7 bits (86), Expect = 0.011
 Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 4/86 (4%)

Query: 134   NEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITE 193
             +EG+  T+ C   G P P+  W     G         GRF I N ++ T L I+++Q  +
Sbjct: 26844 DEGKVLTVACAFTGEPTPEVTW---SCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQ-KQ 26899

Query: 194   DPGEYECNATNAIGSASVVTVLRVRS 219
             D G Y  +  N  GS S    + +RS
Sbjct: 26900 DGGLYTLSLGNEFGSDSATVNIHIRS 26925



 Score = 37.0 bits (84), Expect = 0.019
 Identities = 25/99 (25%), Positives = 41/99 (41%), Gaps = 6/99 (6%)

Query: 121   APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
             AP I    +      G+ A + C+ VG P PD  W +    +         R + ++ + 
Sbjct: 24035 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKEL------IQSRKYKMSSDG 24088

Query: 181   YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
              T    V  +  ED G Y C ATN +G     + L +++
Sbjct: 24089 RTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQA 24127



 Score = 36.6 bits (83), Expect = 0.025
 Identities = 39/133 (29%), Positives = 53/133 (39%), Gaps = 10/133 (7%)

Query: 89   INKPRAED-SGEYHCVYHFVS---APKANATIEVKAAPDITGHKRSENKNEGQDATMYCK 144
            I+K   ED  GEY C     S   A  A  T+  +AAP I           G  A   C+
Sbjct: 4300 IDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCE 4359

Query: 145  SVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
                P+  + W K         +  S +  I + +  + L I+  Q+  D GEY C A+N
Sbjct: 4360 IQSAPNVRFQWFKAGRE-----IYESDKCSIRSSKYISSLEILRTQVV-DCGEYTCKASN 4413

Query: 205  AIGSASVVTVLRV 217
              GS S    L V
Sbjct: 4414 EYGSVSCTATLTV 4426



 Score = 35.4 bits (80), Expect = 0.057
 Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 7/108 (6%)

Query: 110   PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNT 169
             PK++  I+   AP      R+ N     +AT+ CK  G+P P   W ++   +  D +  
Sbjct: 24422 PKSDVPIQ---APHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKY 24478

Query: 170   SGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRV 217
               + F   K  Y +L I ++   +D   Y+  ATN  GS S    L V
Sbjct: 24479 RIQEF---KGGYHQLIIASV-TDDDATVYQVRATNQGGSVSGTASLEV 24522



 Score = 34.7 bits (78), Expect = 0.097
 Identities = 24/85 (28%), Positives = 37/85 (43%), Gaps = 5/85 (5%)

Query: 135  EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITED 194
            EGQ A    K VG P P+  W      +  D  +      ++ KE+ T+  I+      D
Sbjct: 1424 EGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHK-----VVIKEDGTQSLIIVPATPSD 1478

Query: 195  PGEYECNATNAIGSASVVTVLRVRS 219
             GE+   A N  G +S+  +L V +
Sbjct: 1479 SGEWTVVAQNRAGRSSISVILTVEA 1503



 Score = 34.7 bits (78), Expect = 0.097
 Identities = 39/155 (25%), Positives = 64/155 (41%), Gaps = 33/155 (21%)

Query: 68   WTKNGVELSATRKNASNMEYRIN-------KPRAEDSGEYHCVYHFVSAPK-ANATIEVK 119
            W +N + +    K+    E +I+       KPR  D GEY     F++  K A A +E+ 
Sbjct: 6447 WLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPR--DQGEYR----FIAKDKEARAKLELA 6500

Query: 120  AAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTS--------- 170
            AAP I    +    + G+  TM      YP  +  W K+   +    ++T+         
Sbjct: 6501 AAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDTTAEQTSFRIL 6560

Query: 171  -------GRFFII--NKENYTELNIVNLQITEDPG 196
                   GR+ I+  NK    E   +NL++ + PG
Sbjct: 6561 EAKKGDKGRYKIVLQNKHGKAE-GFINLKVIDVPG 6594



 Score = 33.1 bits (74), Expect = 0.28
 Identities = 26/83 (31%), Positives = 35/83 (42%), Gaps = 5/83 (6%)

Query: 135  EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITED 194
            +G  A      VG P P   W K+   +      TS  + II+  N +   IVN    ED
Sbjct: 3588 QGLPAIFEYTVVGEPAPTVTWFKENKQLC-----TSVYYTIIHNPNGSGTFIVNDPQRED 3642

Query: 195  PGEYECNATNAIGSASVVTVLRV 217
             G Y C A N +G ++    L V
Sbjct: 3643 SGLYICKAENMLGESTCAAELLV 3665



 Score = 32.3 bits (72), Expect = 0.48
 Identities = 30/145 (20%), Positives = 57/145 (39%), Gaps = 10/145 (6%)

Query: 74    ELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENK 133
             +++ TR++ S+ E+  +      + E   +    +  K   T+  +    I    RS   
Sbjct: 26020 QMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAAR----ILTKPRSMTV 26075

Query: 134   NEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITE 193
              EG+ A   C + G P P   W +K       +++TS R  +   +  +   I ++Q   
Sbjct: 26076 YEGESARFSCDTDGEPVPTVTWLRKG-----QVLSTSARHQVTTTKYKSTFEISSVQ-AS 26129

Query: 194   DPGEYECNATNAIGSASVVTVLRVR 218
             D G Y     N+ G       L ++
Sbjct: 26130 DEGNYSVVVENSEGKQEAEFTLTIQ 26154



 Score = 31.6 bits (70), Expect = 0.82
 Identities = 27/89 (30%), Positives = 39/89 (43%), Gaps = 7/89 (7%)

Query: 119  KAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINK 178
            K  PDI  +       EG+ A   C+  GYP P   W    NG    ++  S R F +  
Sbjct: 1792 KQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYL--NG---QLIRKSKR-FRVRY 1845

Query: 179  ENYTELNIVNLQITEDPGEYECNATNAIG 207
            +    L+IV+ + + D GE +  A N  G
Sbjct: 1846 DGIHYLDIVDCK-SYDTGEVKVTAENPEG 1873



 Score = 31.6 bits (70), Expect = 0.82
 Identities = 27/84 (32%), Positives = 38/84 (45%), Gaps = 7/84 (8%)

Query: 135   EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKE-NYTELNIVNLQITE 193
             EGQ      +  G P P   W K  +G P+ +        II++  +Y  L+I +  + E
Sbjct: 25311 EGQSVCFEIRVSGIPPPTLKWEK--DGQPLSL---GPNIEIIHEGLDYYALHIRDT-LPE 25364

Query: 194   DPGEYECNATNAIGSASVVTVLRV 217
             D G Y   ATN  GS S    L+V
Sbjct: 25365 DTGYYRVTATNTAGSTSCQAHLQV 25388



 Score = 31.2 bits (69), Expect = 1.1
 Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 8/80 (10%)

Query: 136   GQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQIT-ED 194
             G+D  +     G P P   WRK E  +  D      R+ I N ++ + L I   Q+T  D
Sbjct: 20789 GEDVQVLIPFKGRPPPTVTWRKDEKNLGSD-----ARYSIENTDSSSLLTIP--QVTRND 20841

Query: 195   PGEYECNATNAIGSASVVTV 214
              G+Y     N +G     TV
Sbjct: 20842 TGKYILTIENGVGEPKSSTV 20861



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 26/99 (26%), Positives = 43/99 (43%), Gaps = 5/99 (5%)

Query: 121  APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
            AP I    +S+   +G DA    + VG P P+  W K  NG+ ++   +   ++   ++N
Sbjct: 2031 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYK--NGVKIE--RSDRIYWYWPEDN 2086

Query: 181  YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
              EL ++     ED       A N  G  S    L V++
Sbjct: 2087 VCEL-VIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA 2124



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 39/162 (24%), Positives = 68/162 (41%), Gaps = 16/162 (9%)

Query: 60   SHTLTYSYWTKNGVELSATRKNASNMEYRINK-----PRAEDSGEYHCVYHFVSAPKANA 114
            SH    S W KNGVE+  + K    ++ ++++        EDS EY  V       + +A
Sbjct: 2860 SHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFV---CGNDQVSA 2916

Query: 115  TIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFF 174
            T+ V   P +      +   E +D   +  +V Y    + W K  NG+    + ++ +  
Sbjct: 2917 TLTV--TPIMITSMLKDINAEEKDTITFEVTVNYEGISYKWLK--NGVE---IKSTDKCQ 2969

Query: 175  IINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLR 216
            +  K+    LNI N+    D  +Y   A  A  +A++    R
Sbjct: 2970 MRTKKLTHSLNIRNVHF-GDAADYTFVAGKATSTATLYVEAR 3010



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 42/179 (23%), Positives = 66/179 (36%), Gaps = 38/179 (21%)

Query: 51    TLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYH--------- 101
             TL C +T   H      W + G E+ A       ++YRI     E  G YH         
Sbjct: 24449 TLVCKVTG--HPKPIVKWYRQGKEIIA-----DGLKYRIQ----EFKGGYHQLIIASVTD 24497

Query: 102   ---CVYHFVSAPKAN-----ATIEVKAAPDITGHKRSENKN-----EGQDATMYCKSVGY 148
                 VY   +  +       A++EV+    I   K  E         G+  ++     G 
Sbjct: 24498 DDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGK 24557

Query: 149   PHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIG 207
             P P   W+K +     D+++ +G + +I   ++T L   N    +D G Y   A N  G
Sbjct: 24558 PDPVITWQKGQ-----DLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFG 24611



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 27/110 (24%), Positives = 42/110 (38%), Gaps = 8/110 (7%)

Query: 110   PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNT 169
             PKA   I  K  P I    +    +    A    K+ G P P  IW K    +      T
Sbjct: 26345 PKAPEPISSK--PVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI------T 26396

Query: 170   SGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
              G  + ++++       ++   T D G Y C   N+ GS S    L +++
Sbjct: 26397 QGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKA 26446



 Score = 30.4 bits (67), Expect = 1.8
 Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 7/62 (11%)

Query: 147  GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAI 206
            G P P  +W K+E  +  D      R  I N    +EL I+   + +D G Y   ATN+ 
Sbjct: 8633 GRPVPTKVWTKEEGELDKD------RVVIDNVGTKSEL-IIKDALRKDHGRYVITATNSC 8685

Query: 207  GS 208
            GS
Sbjct: 8686 GS 8687



 Score = 29.6 bits (65), Expect = 3.1
 Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 6/99 (6%)

Query: 120 AAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKE 179
           A P+     +S    +G    +  +  G P P  + +   +G  +     S   F I++E
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTP--VVKFYRDGAEIQ----SSLDFQISQE 155

Query: 180 NYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVR 218
                 ++     ED G Y  NATN++G A+    L V+
Sbjct: 156 GDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 22/75 (29%), Positives = 32/75 (42%), Gaps = 5/75 (6%)

Query: 135  EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITED 194
            EG   T +CK  GYP P   W K  +G  +         F+ +      + +V   + ED
Sbjct: 1258 EGMGVTFHCKMSGYPLPKIAWYK--DGKRIKHGERYQMDFLQDGRASLRIPVV---LPED 1312

Query: 195  PGEYECNATNAIGSA 209
             G Y   A+N  G+A
Sbjct: 1313 EGIYTAFASNIKGNA 1327



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 17/71 (23%), Positives = 30/71 (42%), Gaps = 6/71 (8%)

Query: 147   GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAI 206
             G P P   W    + +  D        + +  +N++ +  +   +  D GEY+   +NA 
Sbjct: 11039 GVPVPTAKWTTDGSEIKTD------EHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAA 11092

Query: 207   GSASVVTVLRV 217
             GS +V   L V
Sbjct: 11093 GSKTVAVHLTV 11103



 Score = 28.9 bits (63), Expect = 5.3
 Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 6/62 (9%)

Query: 147   GYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAI 206
             G PHP   W+K E+    ++V +S     ++K + + + I+     +D G Y   A N+ 
Sbjct: 12427 GKPHPTCKWKKGED----EVVTSS--HLAVHKADSSSILIIKDVTRKDSGYYSLTAENSS 12480

Query: 207   GS 208
             G+
Sbjct: 12481 GT 12482



 Score = 28.5 bits (62), Expect = 6.9
 Identities = 28/103 (27%), Positives = 41/103 (39%), Gaps = 4/103 (3%)

Query: 121 APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKEN 180
           AP  T   +S    EG  AT      G+P P+  W +  +G  +      G   I   + 
Sbjct: 5   APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFR--DGQVISTSTLPG-VQISFSDG 61

Query: 181 YTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAP 223
             +L I  +    + G Y   ATN  G A+    L V++  AP
Sbjct: 62  RAKLTIPAVT-KANSGRYSLKATNGSGQATSTAELLVKAETAP 103



 Score = 28.1 bits (61), Expect = 9.0
 Identities = 18/71 (25%), Positives = 29/71 (40%), Gaps = 6/71 (8%)

Query: 96   DSGEYHCVYH------FVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYP 149
            DSGE+  V         +S       +E +  P      ++ N  EG    M  ++ G P
Sbjct: 1478 DSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNP 1537

Query: 150  HPDWIWRKKEN 160
            +PD +W K  +
Sbjct: 1538 NPDIVWLKNSD 1548



 Score = 28.1 bits (61), Expect = 9.0
 Identities = 21/64 (32%), Positives = 30/64 (46%), Gaps = 4/64 (6%)

Query: 147  GYPHPDWIWRKKENGM--PMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
            G P P   W K E  +  P D +  + +  +   E  TEL+I    + ED G Y   A+N
Sbjct: 8927 GLPMPKIEWSKNETVIEKPTDALQIT-KEEVSRSEAKTELSIPKA-VREDKGTYTVTASN 8984

Query: 205  AIGS 208
             +GS
Sbjct: 8985 RLGS 8988


>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
           sapiens]
          Length = 858

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 59/247 (23%), Positives = 96/247 (38%), Gaps = 40/247 (16%)

Query: 10  LALSLLLVSGSLLPGPGAAQNEPRIVTSEEVIIRDSPVL---PVTLQC--NLTSSSHTLT 64
           L+ + L + G      G  + E RI+   E+  +D  V+   P T+Q   N+ +++  L 
Sbjct: 169 LSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLG 228

Query: 65  YSY---------------WTKNGVELSATRKNAS------NMEYRINKPRAEDSGEYHCV 103
            S                WTK+G ++     +        + +  I K    D  EY C+
Sbjct: 229 QSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288

Query: 104 YHFVSAPKANATIEVK--AAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENG 161
                A + +ATI +K  A P IT  +        +  T+ C++ G P P   WR     
Sbjct: 289 AEN-KAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347

Query: 162 M----------PMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASV 211
           +          P       G   + +    + L + ++Q T D GEY C A+N IG  S 
Sbjct: 348 ISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYT-DAGEYICTASNTIGQDSQ 406

Query: 212 VTVLRVR 218
              L V+
Sbjct: 407 SMYLEVQ 413



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 35/156 (22%), Positives = 61/156 (39%), Gaps = 16/156 (10%)

Query: 54  CNLTSSSHTLTYSYWTKNGVELSATRKNAS-------NMEYRINKPRAEDSGEYHCVYHF 106
           C +   +     S+++ NG +L+  ++  S       +    I     +D+G Y CV   
Sbjct: 41  CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100

Query: 107 VSAPKANATIEVKAAPDI--TGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPM 164
               ++ AT+ VK    +        +   EG+DA + C  V    P  IW+ K      
Sbjct: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGR---- 156

Query: 165 DIVNTSGRFFIINKENYTELNIVNLQITEDPGEYEC 200
           D++      FI+   NY ++  +      D G Y C
Sbjct: 157 DVILKKDVRFIVLSNNYLQIRGIK---KTDEGTYRC 189



 Score = 37.7 bits (86), Expect = 0.011
 Identities = 33/131 (25%), Positives = 50/131 (38%), Gaps = 26/131 (19%)

Query: 96  DSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWI 154
           D+GEY C   + +     +  +EV+ AP + G        EG    + C+   YP     
Sbjct: 389 DAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSATIS 447

Query: 155 WRKKENGMPMDIVNTSGRFFIINKENYTELNIVN------LQITEDP----GEYECNATN 204
           W +    +P                NY+ + I N      L++T D     G Y C A N
Sbjct: 448 WFRDGQLLP--------------SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 493

Query: 205 AIGSASVVTVL 215
            IG  S+  +L
Sbjct: 494 RIGQESLEFIL 504


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 46/160 (28%), Positives = 70/160 (43%), Gaps = 17/160 (10%)

Query: 68   WTKNGVELSA--TRKNASNMEYRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDI 124
            W K G+ ++   + +     + RI     ED+G Y C+  +   +      + V+  P I
Sbjct: 2790 WQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVI 2849

Query: 125  TGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTEL 184
                   +  EG  A + CK+ G P P+  W K  +G P  +    G+F I   +   EL
Sbjct: 2850 ENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK--DGQP--VSGAEGKFTI---QPSGEL 2902

Query: 185  NIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPL 224
             + NL+  +D G Y C A NA+G A      R R HL  L
Sbjct: 2903 LVKNLE-GQDAGTYTCTAENAVGRA------RRRVHLTIL 2935



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 41/162 (25%), Positives = 67/162 (41%), Gaps = 12/162 (7%)

Query: 67   YWTKNGVEL--SATRKNASNMEYRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPD 123
            +W K+G+ L  S  R    N    I++   +D+G Y C+  + +   K    + +++AP 
Sbjct: 3060 HWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPV 3119

Query: 124  ITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTE 183
                 +      G D  + C++ G P P   W +   G P+     S R   +   +   
Sbjct: 3120 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQA--GQPL---RASRRLRTLPDGSLWL 3174

Query: 184  LNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLW 225
             N+     T D G Y+C A N +GSA+    L VR      W
Sbjct: 3175 ENVE----TGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSW 3212



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 60/220 (27%), Positives = 87/220 (39%), Gaps = 25/220 (11%)

Query: 17  VSGSLLPGPGAAQNEPRIVTSEEVIIRDSPVL---PVTLQCNLTSS-SHTLTYSYWTKNG 72
           V+GS     G   N P  +T    +    PVL   PV L CN T + S TL    W K+G
Sbjct: 770 VAGSTELRYGLRVNVPPRITLPPSL--PGPVLVNTPVRLTCNATGAPSPTLM---WLKDG 824

Query: 73  VELSATRKNASNM-----EYRINKPRAEDSGEYHCV-YHFVSAPKANATIEVKAAPDITG 126
             +S        +        +   RA DSG Y CV    V   + +  ++V   P I G
Sbjct: 825 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILG 884

Query: 127 HKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNI 186
            + + +    +   + C+S   P P   W K  +G P++     G     +K     L  
Sbjct: 885 EELNVSVVANESVALECQSHAMPPPVLSWWK--DGRPLE--PRPGVHLSADK----ALLQ 936

Query: 187 VNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWP 226
           V+     D G Y C A N  G +     L V   +AP++P
Sbjct: 937 VDRADVWDAGHYTCEALNQAGRSEKHYNLNV--WVAPVFP 974



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 36/123 (29%), Positives = 57/123 (46%), Gaps = 9/123 (7%)

Query: 96   DSGEYHCVYHFVSAPKANA-TIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWI 154
            DSG+Y C     +   + A  +E+   P I     + N +  Q A + C++ G P P   
Sbjct: 2455 DSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVS 2514

Query: 155  WRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTV 214
            WRK  + +P+D    S RF I+ + +      +   + +D G Y C A+N+ GS      
Sbjct: 2515 WRK--DRVPLD--PRSPRFEILPEGSLR----IQPVLAQDAGHYLCLASNSAGSDRQGRD 2566

Query: 215  LRV 217
            LRV
Sbjct: 2567 LRV 2569



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 11/133 (8%)

Query: 88  RINKPRAEDSGEYHCVYHFVSAPKA-NATIEVKAAPDITGHKRSENKNEGQD--ATMYCK 144
           RI      D G Y CV    +  +A +  + V A P I G   +      +D    + C+
Sbjct: 275 RITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCE 334

Query: 145 SVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
           + G P P+  W K    +P     TS +  ++      +L +   Q + D G Y C A+N
Sbjct: 335 ARGVPTPNITWFKDGALLP-----TSTK--VVYTRGGRQLQLGRAQ-SSDAGVYTCKASN 386

Query: 205 AIGSASVVTVLRV 217
           A+G+A   T L V
Sbjct: 387 AVGAAEKATRLDV 399



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 41/167 (24%), Positives = 66/167 (39%), Gaps = 19/167 (11%)

Query: 52   LQCNLTSSSHTLTYSYWTKNGVELS---ATRKNASNMEYRINKPRAEDSGEYHCVY-HFV 107
            L CN+T   H      W K+G  L+   A   +   +  ++ +     +G Y C+  + V
Sbjct: 1274 LMCNVTG--HPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAV 1331

Query: 108  SAPKANATIEVKAAPDITGHKRSENKNE-----GQDATMYCKSVGYPHPDWIWRKKENGM 162
                 +  + V  AP I G        E         ++ C+++ +P P+  W K  +G 
Sbjct: 1332 GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK--DGA 1389

Query: 163  PMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSA 209
            P +         I        L I+N Q  ED G+Y C  TN +G A
Sbjct: 1390 PFEASRN-----IQLLPGTHGLQILNAQ-KEDAGQYTCVVTNELGEA 1430



 Score = 41.6 bits (96), Expect = 8e-04
 Identities = 46/184 (25%), Positives = 74/184 (40%), Gaps = 22/184 (11%)

Query: 49  PVTLQCNLTSSSHTLTYSYWTKNGV---ELSATRKNASNMEYRINKPRAEDSGEYHCVYH 105
           PV L+C   +  H      W   G+   E + +R        R+  P    SG Y CV  
Sbjct: 422 PVALEC--VARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCV-- 477

Query: 106 FVSAPKANA----TIEVKAAPDITGHKRSENKNE--GQDATMYCKSVGYPHPDWIWRKKE 159
             S+P   A    ++EV+  P +   +         GQ   + C++ G P P   W   +
Sbjct: 478 -ASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWL--Q 534

Query: 160 NGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
           NG P +    +G   +      T L+I ++++ +  G + C ATN  G+A     + V  
Sbjct: 535 NGRPAE--ELAG---VQVASQGTTLHIDHVEL-DHSGLFACQATNEAGTAGAEVEVSVHG 588

Query: 220 HLAP 223
             AP
Sbjct: 589 EWAP 592



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 32/123 (26%), Positives = 54/123 (43%), Gaps = 11/123 (8%)

Query: 88   RINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSE--NKNEGQDATMYCK 144
            ++ + + +DSG Y C+  +     + N ++EV   P I      E     +GQ A + C 
Sbjct: 1218 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 1277

Query: 145  SVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
              G+P P   W K  +G P+      G    I+ +    L ++   ++   G Y C A N
Sbjct: 1278 VTGHPQPKLTWFK--DGRPL----ARGDAHHISPDGVL-LQVLQANLS-SAGHYSCIAAN 1329

Query: 205  AIG 207
            A+G
Sbjct: 1330 AVG 1332



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 45/166 (27%), Positives = 75/166 (45%), Gaps = 16/166 (9%)

Query: 49   PVTLQCNLTS-SSHTLTYSYWTKNG--VELSATRKNASNM-EYRINKPRAEDSGEYHCVY 104
            P+ L C+++   + T+T   W K+   VE SA     S     ++++ +   +G Y CV 
Sbjct: 1950 PLVLTCDVSGVPAPTVT---WLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVA 2006

Query: 105  HFVSAP-KANATIEVKAAPDI--TGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENG 161
                A  + +  + V  AP I  +G  R  +  EGQ+  + C++ G P PD  W K  + 
Sbjct: 2007 ENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSP 2066

Query: 162  MPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIG 207
            +  D +    RF++    +   L +  L+   D G Y C A N  G
Sbjct: 2067 LGQD-MGPHLRFYL----DGGSLVLKGLR-ASDAGAYTCVAHNPAG 2106



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 45/184 (24%), Positives = 73/184 (39%), Gaps = 23/184 (12%)

Query: 45   SPVLPVTLQCNLTSSSH-TLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCV 103
            +P  P+ L C+   +    +T   W K+G  L+    N+          R  D+G Y C+
Sbjct: 2317 TPGAPMELLCDAQGTPQPNIT---WHKDGQALTRLENNSRATRVL----RVRDAGLYTCL 2369

Query: 104  YHF-VSAPKANATIEVKAAPDITGHKRSE---NKNEGQDATMYCKSVGYPHPDWIWRKKE 159
                  A + +  + V+A P+I G +          GQ   + C     P P   W +  
Sbjct: 2370 AESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ-LVLECSVEAEPAPKITWHR-- 2426

Query: 160  NGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRS 219
            +G+   ++          +  + +L  ++   T D G+Y C A NA GS SV    RV  
Sbjct: 2427 DGI---VLQEDAHTQFPERGRFLQLQALS---TADSGDYSCTARNAAGSTSV--AFRVEI 2478

Query: 220  HLAP 223
            H  P
Sbjct: 2479 HTVP 2482



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 36/134 (26%), Positives = 52/134 (38%), Gaps = 15/134 (11%)

Query: 88  RINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSV 146
           +I K    D G Y C   +     K    ++V   P+I     ++   E    T+ C + 
Sbjct: 660 QIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLAS 719

Query: 147 GYPHPDWIWRKKENGMPMDI---VNTSGRFFIINKENYTELNIVNLQITEDPGEYECNAT 203
           G P PD  W K    +   +   V+  GR           L I   Q++ D G Y C A+
Sbjct: 720 GVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------LRIEQAQLS-DAGSYRCVAS 768

Query: 204 NAIGSASVVTVLRV 217
           N  GS  +   LRV
Sbjct: 769 NVAGSTELRYGLRV 782



 Score = 37.4 bits (85), Expect = 0.015
 Identities = 23/74 (31%), Positives = 36/74 (48%), Gaps = 5/74 (6%)

Query: 96  DSGEYHC-VYHFVSAPKANATIEVKAAPDIT--GHKRSENKNEGQDATMYCKSVGYPHPD 152
           DSG+Y C   + V +    A + V   P I   G K + +   GQ  T+ C + G+P P+
Sbjct: 68  DSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPE 127

Query: 153 WIWRKKEN--GMPM 164
            +W K     G+P+
Sbjct: 128 IVWLKDAQLVGVPL 141



 Score = 36.2 bits (82), Expect = 0.033
 Identities = 42/204 (20%), Positives = 75/204 (36%), Gaps = 29/204 (14%)

Query: 32   PRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSY--WTKNGVELS---ATRKNASNME 86
            P  +  EE+ +       V L+C     SH +      W K+G  L        +A    
Sbjct: 879  PPSILGEELNVSVVANESVALECQ----SHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL 934

Query: 87   YRINKPRAEDSGEYHC-VYHFVSAPKANATIEVKAAPDIT-GHKRSENKNEGQDATMYCK 144
             ++++    D+G Y C   +     + +  + V  AP        +    EG   ++ C+
Sbjct: 935  LQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCE 994

Query: 145  SVGYPHPDWIWRKKENGMP-----MDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYE 199
              G P P   WRK    +P     +  V+  GR   + +    +            G Y 
Sbjct: 995  CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQ-----------EGTYT 1043

Query: 200  CNATNAIGSASVVTVLRVRSHLAP 223
            C  +N +G++S    L++  H+ P
Sbjct: 1044 CECSNVVGNSS--QDLQLEVHVPP 1065



 Score = 35.4 bits (80), Expect = 0.057
 Identities = 33/131 (25%), Positives = 53/131 (40%), Gaps = 13/131 (9%)

Query: 93   RAEDSGEYHC-VYHFVSAPKANATIEVKAAPDITGHKRS----ENKNEGQDATMYCKSVG 147
            RAE++G Y C   + V     +  + V   P I G           N     ++ C ++G
Sbjct: 1621 RAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALG 1680

Query: 148  YPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIG 207
             P P   W   +NG+P    + S R  ++      +++   +    D   Y C A N  G
Sbjct: 1681 NPVPTISWL--QNGLPF---SPSPRLQVLEDGQVLQVSTAEVA---DAASYMCVAENQAG 1732

Query: 208  SASVVTVLRVR 218
            SA  +  LRV+
Sbjct: 1733 SAEKLFTLRVQ 1743



 Score = 34.7 bits (78), Expect = 0.097
 Identities = 23/73 (31%), Positives = 29/73 (39%), Gaps = 17/73 (23%)

Query: 143 CKSVGYPHPDWIWRKKEN-----GMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGE 197
           C + G P P   WRK  +     G P   V   G  F+ +                D G+
Sbjct: 24  CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVS------------PADSGD 71

Query: 198 YECNATNAIGSAS 210
           YEC ATN +GS S
Sbjct: 72  YECQATNEVGSTS 84



 Score = 34.3 bits (77), Expect = 0.13
 Identities = 43/200 (21%), Positives = 77/200 (38%), Gaps = 33/200 (16%)

Query: 32   PRIVTSEEVIIRDSPVLPVTLQCNLTS-SSHTLTYSYWTKNGVELSATRKNASNMEYRIN 90
            P  +  ++     + + PV L C+ T   + T++   W+K G +L A         YR++
Sbjct: 2665 PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS---WSKAGAQLGARGSG-----YRVS 2716

Query: 91   KPRAED--------SGEYHC-VYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATM 141
               A +        +G Y C   +       +  + V+A+P +            ++  +
Sbjct: 2717 PSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 2776

Query: 142  YCKSVGYPHPDWIWRKKENGMPMDI---VNTSGRFFIINKENYTELNIVNLQITEDPGEY 198
             C++ G P P   W+K+   +   +   V   G+  I +               ED G Y
Sbjct: 2777 PCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHAS------------PEDAGNY 2824

Query: 199  ECNATNAIGSASVVTVLRVR 218
             C A N+ GSA   T L V+
Sbjct: 2825 LCIAKNSAGSAMGKTRLVVQ 2844



 Score = 33.5 bits (75), Expect = 0.22
 Identities = 39/185 (21%), Positives = 70/185 (37%), Gaps = 17/185 (9%)

Query: 38   EEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNA---SNMEYRINKPRA 94
            EEV +  S    V+LQC   +  + +    W +NG+  S + +          +++    
Sbjct: 1662 EEVTVNASST--VSLQC--PALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEV 1717

Query: 95   EDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSE-NKNEGQDATMYCKSVGYPHPD 152
             D+  Y CV  +   + +   T+ V+  P I G    +         ++ C    +P+P+
Sbjct: 1718 ADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPE 1777

Query: 153  WIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVV 212
              W K    + +         F++   +  +L    L    D G Y C A NA G    +
Sbjct: 1778 VTWYKDSQALSL-----GEEVFLLPGTHTLQLGRARLS---DSGMYTCEALNAAGRDQKL 1829

Query: 213  TVLRV 217
              L V
Sbjct: 1830 VQLSV 1834



 Score = 32.0 bits (71), Expect = 0.63
 Identities = 42/189 (22%), Positives = 73/189 (38%), Gaps = 28/189 (14%)

Query: 32   PRIVTSEEVIIRDSPVLPVTLQCNLTSSSH-TLTYSYWTKNG----VELSATRKNASNME 86
            PR   ++  +++D      TL+CN T     T+T   W ++G     EL    +N     
Sbjct: 1070 PREPPTQVSVVQDGVA---TLECNATGKPPPTVT---WERDGQPVGAELGLQLQN-QGQS 1122

Query: 87   YRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENKNEG---QDATMY 142
              + + +A  +G Y CV  +     +    + V   P++ G                T+ 
Sbjct: 1123 LHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLL 1182

Query: 143  CKSVGYPHPDWIWRKKENGMPM--DIVNTSGRFFIINKENYTELNIVNLQITEDPGEYEC 200
            C+++G P P   W + E  +    D    +G + +  K   T+         +D G Y C
Sbjct: 1183 CEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML--KMTQTQ--------EQDSGLYSC 1232

Query: 201  NATNAIGSA 209
             A+N  G A
Sbjct: 1233 LASNEAGEA 1241



 Score = 31.2 bits (69), Expect = 1.1
 Identities = 16/73 (21%), Positives = 31/73 (42%), Gaps = 8/73 (10%)

Query: 135  EGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITED 194
            E   A +YC +   P PD  W +++  +     +      ++      ++ +V     E+
Sbjct: 1573 ENNPAYLYCDTNAIPPPDLTWYREDQPL-----SAGDEVSVLQGGRVLQIPLVR---AEN 1624

Query: 195  PGEYECNATNAIG 207
             G Y C A+N +G
Sbjct: 1625 AGRYSCKASNEVG 1637



 Score = 30.0 bits (66), Expect = 2.4
 Identities = 30/125 (24%), Positives = 47/125 (37%), Gaps = 12/125 (9%)

Query: 89   INKPRAEDSGEYHC-VYHFVSAPKANATIEVKAAPDITGHKRSENK-NEGQD--ATMYCK 144
            + + +    G Y C   + V     +  +EV   P I G +    + +  QD  AT+ C 
Sbjct: 1031 LGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECN 1090

Query: 145  SVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATN 204
            + G P P   W +  +G P+      G    +  +N  +   V        G Y C A N
Sbjct: 1091 ATGKPPPTVTWER--DGQPV------GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN 1142

Query: 205  AIGSA 209
              G A
Sbjct: 1143 LAGRA 1147



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 43/205 (20%), Positives = 74/205 (36%), Gaps = 25/205 (12%)

Query: 26   GAAQNEPRIVTSEEVIIRDS-PVLPVT------LQCNLTSSSH-TLTYSYWTKNGVELSA 77
            G+A  + R+V     +I +  P L  T      L C    S    +T   W K+G  +S 
Sbjct: 2833 GSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT---WDKDGQPVSG 2889

Query: 78   TRKNAS---NMEYRINKPRAEDSGEYHCVY-HFVSAPKANATIEVKAAPDITGHKRSENK 133
                 +   + E  +     +D+G Y C   + V   +    + +   P  T      + 
Sbjct: 2890 AEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL 2949

Query: 134  NEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITE 193
              G    + C + G P P   W   +  +      T G   +  ++  + L    +   E
Sbjct: 2950 RLGDRLWLRCAARGSPTPRIGWTVNDRPV------TEG---VSEQDGGSTLQRAAVS-RE 2999

Query: 194  DPGEYECNATNAIGSASVVTVLRVR 218
            D G Y C A N +G    V+ + V+
Sbjct: 3000 DSGTYVCWAENRVGRTQAVSFVHVK 3024


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,484,061
Number of Sequences: 37866
Number of extensions: 512718
Number of successful extensions: 2474
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 107
Number of HSP's successfully gapped in prelim test: 219
Number of HSP's that attempted gapping in prelim test: 1275
Number of HSP's gapped (non-prelim): 1003
length of query: 282
length of database: 18,247,518
effective HSP length: 101
effective length of query: 181
effective length of database: 14,423,052
effective search space: 2610572412
effective search space used: 2610572412
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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