Search of human proteins with 92110019

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|92110019 hypothetical protein LOC55672 [Homo sapiens]
         (1214 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|92110019 hypothetical protein LOC55672 [Homo sapiens]             2427   0.0  
gi|83415174 hypothetical protein LOC400818 [Homo sapiens]            1752   0.0  
gi|224589132 hypothetical protein LOC100132406 [Homo sapiens]        1702   0.0  
gi|239741309 PREDICTED: hypothetical protein XP_002344485 [Homo ...  1694   0.0  
gi|119709825 neuroblastoma breakpoint family, member 11-like [Ho...  1342   0.0  
gi|156071420 hypothetical protein LOC728912 [Homo sapiens]           1340   0.0  
gi|157266285 hypothetical protein LOC728936 [Homo sapiens]           1271   0.0  
gi|29789405 hypothetical protein LOC284565 [Homo sapiens]            1268   0.0  
gi|169162915 PREDICTED: hypothetical protein LOC728841 [Homo sap...  1226   0.0  
gi|7657017 hypothetical protein LOC25832 [Homo sapiens]              1078   0.0  
gi|14149997 neuroblastoma breakpoint family, member 3 [Homo sapi...   836   0.0  
gi|239741297 PREDICTED: neuroblastoma breakpoint family, member ...   526   e-149
gi|221136844 neuroblastoma breakpoint family, member 6 isoform 1...   476   e-134
gi|221136848 neuroblastoma breakpoint family, member 6 isoform 2...   472   e-132
gi|221218991 neuroblastoma breakpoint family, member 4 [Homo sap...   472   e-132
gi|114158664 hypothetical protein LOC343505 [Homo sapiens]            472   e-132
gi|239758011 PREDICTED: hypothetical protein LOC728841, partial ...   231   2e-60
gi|239747446 PREDICTED: similar to Neuroblastoma breakpoint fami...   119   2e-26
gi|239741304 PREDICTED: similar to Neuroblastoma breakpoint fami...   116   1e-25
gi|239741281 PREDICTED: Neuroblastoma breakpoint family member 6...   116   1e-25
gi|239752894 PREDICTED: Neuroblastoma breakpoint family member 6...   113   1e-24
gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ...    85   4e-16
gi|115511012 coiled-coil domain containing 136 [Homo sapiens]          84   6e-16
gi|21735548 centrosomal protein 2 [Homo sapiens]                       75   5e-13
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         73   1e-12
gi|71061468 centromere protein E [Homo sapiens]                        72   4e-12
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    71   7e-12
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             70   9e-12
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    70   1e-11
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    70   1e-11

>gi|92110019 hypothetical protein LOC55672 [Homo sapiens]
          Length = 1214

 Score = 2427 bits (6289), Expect = 0.0
 Identities = 1214/1214 (100%), Positives = 1214/1214 (100%)

Query: 1    MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
            MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY
Sbjct: 1    MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60

Query: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
            EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120

Query: 121  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
            RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE
Sbjct: 121  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180

Query: 181  KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
            KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL
Sbjct: 181  KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240

Query: 241  VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 300
            VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA
Sbjct: 241  VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 300

Query: 301  EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA 360
            EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA
Sbjct: 301  EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA 360

Query: 361  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420
            EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 361  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420

Query: 421  EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAI 480
            EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAI
Sbjct: 421  EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAI 480

Query: 481  TCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATN 540
            TCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATN
Sbjct: 481  TCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATN 540

Query: 541  VSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKY 600
            VSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKY
Sbjct: 541  VSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKY 600

Query: 601  KYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 660
            KYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD
Sbjct: 601  KYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 660

Query: 661  ASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEV 720
            ASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEV
Sbjct: 661  ASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEV 720

Query: 721  AEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 780
            AEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS
Sbjct: 721  AEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 780

Query: 781  TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 840
            TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS
Sbjct: 781  TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 840

Query: 841  IPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGP 900
            IPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGP
Sbjct: 841  IPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGP 900

Query: 901  EVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDP 960
            EVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDP
Sbjct: 901  EVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDP 960

Query: 961  SCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV 1020
            SCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV
Sbjct: 961  SCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV 1020

Query: 1021 DRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSS 1080
            DRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSS
Sbjct: 1021 DRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSS 1080

Query: 1081 FYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLM 1140
            FYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLM
Sbjct: 1081 FYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLM 1140

Query: 1141 EVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVDNRFLTLMGT 1200
            EVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVDNRFLTLMGT
Sbjct: 1141 EVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVDNRFLTLMGT 1200

Query: 1201 SLHLVFQMGVIFPQ 1214
            SLHLVFQMGVIFPQ
Sbjct: 1201 SLHLVFQMGVIFPQ 1214


>gi|83415174 hypothetical protein LOC400818 [Homo sapiens]
          Length = 942

 Score = 1752 bits (4537), Expect = 0.0
 Identities = 884/943 (93%), Positives = 905/943 (95%), Gaps = 1/943 (0%)

Query: 272  MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKY 331
            MVVSAGP SSEKAEMNILE+NEKLRPQLAE KQQF NLKE+CF+TQLAGFLAN+Q KYKY
Sbjct: 1    MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFGNLKERCFLTQLAGFLANRQKKYKY 60

Query: 332  EECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 391
            EEC+DLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQL+EKLREGRDAS
Sbjct: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLKEKLREGRDAS 120

Query: 392  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 451
            RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEE E
Sbjct: 121  RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDE 180

Query: 452  KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL 511
            KVLES APREVQKAEESKV EDSLEECAITCSNSHGPCDSNQPHKNI ITFEED+VNS L
Sbjct: 181  KVLESPAPREVQKAEESKVTEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL 240

Query: 512  VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 571
            VVDRESSHDECQDA+NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILE+NEKLRPQLA
Sbjct: 241  VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLA 300

Query: 572  EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQA 631
            EKKQQFRNLKEKCF+TQLA FLANQQNKYKYEECKDLIK +LRNERQFKEEKLAEQLKQA
Sbjct: 301  EKKQQFRNLKEKCFLTQLAGFLANQQNKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQA 360

Query: 632  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 691
            EELRQYKVLVH+QERELTQLREKLREGRDASRSLN+HLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 361  EELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 420

Query: 692  EGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI 751
            EGCRLAQ L QKLSPENDND +EDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
Sbjct: 421  EGCRLAQHLVQKLSPENDNDDNEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI 480

Query: 752  TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEK 811
            T SNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVE EDAVHIIPENESDDEEEEEK
Sbjct: 481  TYSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEREDAVHIIPENESDDEEEEEK 540

Query: 812  GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIG 871
            GPVSPRNLQESEEEEVPQESWDEGYST SIPPEMLASY+SYS TFHSLEEQQVCMAVDIG
Sbjct: 541  GPVSPRNLQESEEEEVPQESWDEGYSTPSIPPEMLASYKSYSSTFHSLEEQQVCMAVDIG 600

Query: 872  GHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAF 931
             HRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSL RCYSTPSG LELTDSCQPYRSAF
Sbjct: 601  RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLYRCYSTPSGCLELTDSCQPYRSAF 660

Query: 932  YILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG 991
            Y+LEQQRVG A+DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSL R YSTPSG
Sbjct: 661  YVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLGRWYSTPSG 720

Query: 992  YLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPE 1051
            Y ELPDLGQPY SAVYSLEEQYLGLALD+DRIKKDQEEEEDQGPPCPRLSRELLE VEPE
Sbjct: 721  YPELPDLGQPYSSAVYSLEEQYLGLALDLDRIKKDQEEEEDQGPPCPRLSRELLEVVEPE 780

Query: 1052 VLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR 1111
            VLQDSLDRCYSTPSSCLEQPDS  PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
Sbjct: 781  VLQDSLDRCYSTPSSCLEQPDSWQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR 840

Query: 1112 STKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQH 1171
            S KK RRRGRKEGEEDQNPPCPRL+G+LMEVEEPEVLQDSLD CYSTPSMYFELPDSFQH
Sbjct: 841  S-KKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQH 899

Query: 1172 YRSVFYSFEEQHISFALDVDNRFLTLMGTSLHLVFQMGVIFPQ 1214
            YRSVFYSFEEQHISFAL VDNRF TL  TSLHLVFQM VIFPQ
Sbjct: 900  YRSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMEVIFPQ 942



 Score = 1052 bits (2720), Expect = 0.0
 Identities = 609/990 (61%), Positives = 695/990 (70%), Gaps = 115/990 (11%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
           MVVSAGPWSSEKAE NILEINEKLRPQLAENKQQF NLKE+CF+TQLAGFLANRQKKYKY
Sbjct: 1   MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFGNLKERCFLTQLAGFLANRQKKYKY 60

Query: 61  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
           EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQL+EKLREGRDAS
Sbjct: 61  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLKEKLREGRDAS 120

Query: 121 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
           RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEE E
Sbjct: 121 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDE 180

Query: 181 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
           KVLES APREVQKAEESKV EDSLEECAITCSNSHGPCDSNQPHKNI ITFEED+VNSTL
Sbjct: 181 KVLESPAPREVQKAEESKVTEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL 240

Query: 241 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 300
           VVDRESSHDECQDA+NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILE+NEKLRPQLA
Sbjct: 241 VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLA 300

Query: 301 EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA 360
           EKKQQFRNLKEKCF+TQLAGFLANQQNKYKYEEC+DLIK MLRNERQFKEEKLAEQLKQA
Sbjct: 301 EKKQQFRNLKEKCFLTQLAGFLANQQNKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQA 360

Query: 361 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420
           EELRQYKVLVH+QERELTQLREKLREGRDASRSLN+HLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 361 EELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 420

Query: 421 EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAI 480
           EGCRLAQHLVQKLSPEND D++EDVQVE AEKV +SSAPRE+QKAEE +VPEDSLEECAI
Sbjct: 421 EGCRLAQHLVQKLSPENDNDDNEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI 480

Query: 481 TCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATN 540
           T SNSHGP DSNQPH+   ITFEEDKV+S L+    SSH E +DAV+I+P      + ++
Sbjct: 481 TYSNSHGPYDSNQPHRKTKITFEEDKVDSTLI--GSSSHVEREDAVHIIP-----ENESD 533

Query: 541 VSMVVSAGPLSSEKAEMNILEMNEKLRPQ----------------LAEKK---QQFRNLK 581
                  GP+S      N+ E  E+  PQ                LA  K     F +L+
Sbjct: 534 DEEEEEKGPVSPR----NLQESEEEEVPQESWDEGYSTPSIPPEMLASYKSYSSTFHSLE 589

Query: 582 EKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQL---KQAEELRQYK 638
           E     Q  C +A    ++++++ K       + +++    +L+ +L   K  E L+   
Sbjct: 590 E-----QQVC-MAVDIGRHRWDQVK-------KEDQEATGPRLSRELLDEKGPEVLQDSL 636

Query: 639 VLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQ 698
              +S      +L +  +  R A   L Q  +  L  D  +  + Q+++E     C    
Sbjct: 637 YRCYSTPSGCLELTDSCQPYRSAFYVLEQQ-RVGLAVDMDEIEKYQEVEEDQDPSC---- 691

Query: 699 QLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHG 758
               +LS                         RE+   +E EV +DSL     T S    
Sbjct: 692 ---PRLS-------------------------RELLDEKEPEVLQDSLGRWYSTPSGYPE 723

Query: 759 PYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSP-- 816
             D  QP+     + EE  +   L               +   + D EEEE++GP  P  
Sbjct: 724 LPDLGQPYSSAVYSLEEQYLGLAL--------------DLDRIKKDQEEEEDQGPPCPRL 769

Query: 817 -RNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIG---- 871
            R L E  E EV Q+S D  YST S   E   S+Q Y  +F++LEE+ V  ++D+G    
Sbjct: 770 SRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSWQPYGSSFYALEEKHVGFSLDVGEIEK 829

Query: 872 --------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSG 916
                   G R  + ++       EDQ    PRL+  L++ + PEVLQDSLD CYSTPS 
Sbjct: 830 KGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSM 889

Query: 917 YLELTDSCQPYRSAFYILEQQRVGWALDMD 946
           Y EL DS Q YRS FY  E+Q + +AL +D
Sbjct: 890 YFELPDSFQHYRSVFYSFEEQHISFALYVD 919


>gi|224589132 hypothetical protein LOC100132406 [Homo sapiens]
          Length = 3628

 Score = 1702 bits (4408), Expect = 0.0
 Identities = 856/920 (93%), Positives = 878/920 (95%), Gaps = 1/920 (0%)

Query: 272  MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKY 331
            MVVSAGP SSEKAEMNILE+NE LRPQLAEKKQQFRNLKEKCF+TQLAGFLAN+Q KYKY
Sbjct: 1    MVVSAGPWSSEKAEMNILEINETLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKY 60

Query: 332  EECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 391
            EEC+DLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120

Query: 392  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 451
            RSL +HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE
Sbjct: 121  RSLYEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180

Query: 452  KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL 511
            KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNI ITFEED+VNS L
Sbjct: 181  KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL 240

Query: 512  VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 571
            VVDRESSHDECQDA+NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILE+NEKLRPQLA
Sbjct: 241  VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLA 300

Query: 572  EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQA 631
            EKKQQFRNLKEKCF+TQL+ FLANQQ KYKYEECKDLIK +LRNERQFKEEKLAEQLKQA
Sbjct: 301  EKKQQFRNLKEKCFLTQLSGFLANQQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQA 360

Query: 632  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 691
            EELRQYKVLVH+QERELTQL+EKLREGRDASRSLN+HLQALLTP EPDKSQGQDLQEQLA
Sbjct: 361  EELRQYKVLVHAQERELTQLKEKLREGRDASRSLNEHLQALLTPYEPDKSQGQDLQEQLA 420

Query: 692  EGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI 751
            EGCRLAQ L QKLSPENDND DEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI
Sbjct: 421  EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI 480

Query: 752  TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEK 811
            T SNSHG YDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEK
Sbjct: 481  TYSNSHGSYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEK 540

Query: 812  GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIG 871
            GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYS TFHSLEEQQVCMAVDIG
Sbjct: 541  GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIG 600

Query: 872  GHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAF 931
             HRWDQVKKEDQEATGPRLSRELLDEKGPEV QDS DRCYSTPSG LELTDSCQPYRSAF
Sbjct: 601  RHRWDQVKKEDQEATGPRLSRELLDEKGPEVFQDSQDRCYSTPSGCLELTDSCQPYRSAF 660

Query: 932  YILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG 991
            YILEQQRVG A+DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG
Sbjct: 661  YILEQQRVGLAIDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG 720

Query: 992  YLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPE 1051
            YLELPDLGQPY SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLE VEPE
Sbjct: 721  YLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPE 780

Query: 1052 VLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR 1111
            VLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
Sbjct: 781  VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR 840

Query: 1112 STKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQH 1171
            S KK RRRGRKEGEEDQNPPCPRLS  L++ + PEVLQDSLDRCYSTPS   EL DS Q 
Sbjct: 841  S-KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQP 899

Query: 1172 YRSVFYSFEEQHISFALDVD 1191
            YRS FY  E+Q + FA+D+D
Sbjct: 900  YRSAFYVLEQQRVGFAVDMD 919



 Score = 1537 bits (3980), Expect = 0.0
 Identities = 846/1226 (69%), Positives = 926/1226 (75%), Gaps = 98/1226 (7%)

Query: 1    MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
            MVVSAGPWSSEKAE NILEINE LRPQLAE KQQFRNLKEKCF+TQLAGFLANRQKKYKY
Sbjct: 1    MVVSAGPWSSEKAEMNILEINETLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKY 60

Query: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
            EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120

Query: 121  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
            RSL +HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE
Sbjct: 121  RSLYEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180

Query: 181  KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
            KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNI ITFEED+VNSTL
Sbjct: 181  KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL 240

Query: 241  VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 300
            VVDRESSHDECQDA+NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILE+NEKLRPQLA
Sbjct: 241  VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLA 300

Query: 301  EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA 360
            EKKQQFRNLKEKCF+TQL+GFLANQQ KYKYEEC+DLIK MLRNERQFKEEKLAEQLKQA
Sbjct: 301  EKKQQFRNLKEKCFLTQLSGFLANQQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQA 360

Query: 361  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420
            EELRQYKVLVH+QERELTQL+EKLREGRDASRSLN+HLQALLTP EPDKSQGQDLQEQLA
Sbjct: 361  EELRQYKVLVHAQERELTQLKEKLREGRDASRSLNEHLQALLTPYEPDKSQGQDLQEQLA 420

Query: 421  EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAI 480
            EGCRLAQHLVQKLSPEND D+DEDVQVE AEKV +SSAPRE+QKAEE +VPEDSLEECAI
Sbjct: 421  EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI 480

Query: 481  TCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILP---------- 530
            T SNSHG  DSNQPH+   ITFEEDKV+S L+    SSH E +DAV+I+P          
Sbjct: 481  TYSNSHGSYDSNQPHRKTKITFEEDKVDSTLI--GSSSHVEWEDAVHIIPENESDDEEEE 538

Query: 531  VPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLA 590
              GP S            P  S     + L +  ++          F +L+E     Q  
Sbjct: 539  EKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEE-----QQV 593

Query: 591  CFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ 650
            C +A    ++++++ K             KE++ A   + + EL   K            
Sbjct: 594  C-MAVDIGRHRWDQVK-------------KEDQEATGPRLSRELLDEKG----------- 628

Query: 651  LREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDN 710
              E  ++ +D   S       L    +P +S    L++             Q++    D 
Sbjct: 629  -PEVFQDSQDRCYSTPSGCLELTDSCQPYRSAFYILEQ-------------QRVGLAIDM 674

Query: 711  DHDEDVQVEVAEKVQKSSAP---REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHR 767
            D  E  Q    E+ Q  S P   RE+   +E EV +DSL+ C  T S      D  QP+ 
Sbjct: 675  DEIEKYQ--EVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 732

Query: 768  KTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSP---RNLQESEE 824
                + EE  +   L               +   + D EEEE++GP  P   R L E  E
Sbjct: 733  SAVYSLEEQYLGLAL--------------DVDRIKKDQEEEEDQGPPCPRLSRELLEVVE 778

Query: 825  EEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIG------------G 872
             EV Q+S D  YST S   E   S Q Y  +F++LEE+ V  ++D+G            G
Sbjct: 779  PEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRG 838

Query: 873  HRWDQVKK-------EDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQ 925
             R  + ++       EDQ    PRLSRELLDEKGPEVLQDSLDRCYSTPSG LELTDSCQ
Sbjct: 839  RRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQ 898

Query: 926  PYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRC 985
            PYRSAFY+LEQQRVG+A+DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRC
Sbjct: 899  PYRSAFYVLEQQRVGFAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRC 958

Query: 986  YSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL 1045
            YSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL
Sbjct: 959  YSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL 1018

Query: 1046 EAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGK 1105
            E VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKGK
Sbjct: 1019 EVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGK 1078

Query: 1106 KRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFEL 1165
            KRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ + PEVLQDSLDRCYSTPS   EL
Sbjct: 1079 KRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL 1137

Query: 1166 PDSFQHYRSVFYSFEEQHISFALDVD 1191
             DS Q YRS FY  E+Q + FA+D+D
Sbjct: 1138 TDSCQPYRSAFYVLEQQRVGFAVDMD 1163



 Score = 1027 bits (2656), Expect = 0.0
 Identities = 632/1243 (50%), Positives = 747/1243 (60%), Gaps = 159/1243 (12%)

Query: 1    MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
            MVVSAGP SSEKAE NILEINEKLRPQLAE KQQFRNLKEKCF+TQL+GFLAN+QKKYKY
Sbjct: 272  MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLSGFLANQQKKYKY 331

Query: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
            EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQL+EKLREGRDAS
Sbjct: 332  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLKEKLREGRDAS 391

Query: 121  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
            RSLN+HLQALLTP EPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE AE
Sbjct: 392  RSLNEHLQALLTPYEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 451

Query: 181  KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
            KV +SSAPRE+QKAEE +VPEDSLEECAIT SNSHG  DSNQPH+   ITFEEDKV+STL
Sbjct: 452  KVQKSSAPREMQKAEEKEVPEDSLEECAITYSNSHGSYDSNQPHRKTKITFEEDKVDSTL 511

Query: 241  VVDRESSHDECQDAVNILPV----------PGPTSSATNVSMVVSAGPLSSEKAEMNILE 290
            +    SSH E +DAV+I+P            GP S            P  S     + L 
Sbjct: 512  I--GSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 569

Query: 291  MNEKLRPQLAEKKQQFRNLKEK--CFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQF 348
            +  ++          F +L+E+  C    +     +Q  K      ED   +  R  R+ 
Sbjct: 570  IPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKK------EDQEATGPRLSREL 623

Query: 349  KEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPD 408
             +EK  E  + +++        +S      +L +  +  R A   L Q    L       
Sbjct: 624  LDEKGPEVFQDSQDR------CYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAI----- 672

Query: 409  KSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR---EVQKA 465
                                           D DE  + +E E+  + S PR   E+   
Sbjct: 673  -------------------------------DMDEIEKYQEVEEDQDPSCPRLSRELLDE 701

Query: 466  EESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDA 525
            +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR     E ++ 
Sbjct: 702  KEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEE- 760

Query: 526  VNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCF 585
                                  GP     +     E+ E + P++ +         ++C+
Sbjct: 761  --------------------DQGPPCPRLSR----ELLEVVEPEVLQDSL------DRCY 790

Query: 586  VTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQE 645
             T  +C            E  D  +    +    +E+ +   L   E  ++ K       
Sbjct: 791  STPSSCL-----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGR 839

Query: 646  RELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE---------QLAEGCRL 696
            R   + R   +EG +        L   L  ++  +     L           +L + C+ 
Sbjct: 840  RSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQP 899

Query: 697  AQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPEDSLEECA 750
             +  F  L  +      D DE  + +  E+ Q  S PR   E+   +E EV +DSL+ C 
Sbjct: 900  YRSAFYVLEQQRVGFAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCY 959

Query: 751  ITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEE 810
             T S      D  QP+     + EE  +   L               +   + D EEEE+
Sbjct: 960  STPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------------VDRIKKDQEEEED 1005

Query: 811  KGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMA 867
            +GP  PR    L E  E EV Q+S D  YST S   E   S Q Y  +F++LEE+ V  +
Sbjct: 1006 QGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFS 1065

Query: 868  VDIG------------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPEVLQDSLD 908
            +D+G            G R  + ++       EDQ    PRLSRELLDEKGPEVLQDSLD
Sbjct: 1066 LDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLD 1125

Query: 909  RCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRE 968
            RCYSTPSG LELTDSCQPYRSAFY+LEQQRVG+A+DMDEIEKYQEVEEDQDPSCPRLSRE
Sbjct: 1126 RCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAVDMDEIEKYQEVEEDQDPSCPRLSRE 1185

Query: 969  LLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQE 1028
            LLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDRIKKD+E
Sbjct: 1186 LLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDEE 1245

Query: 1029 EEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKH 1088
            EEEDQ PPCPRLSRELLE V PEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALEEKH
Sbjct: 1246 EEEDQDPPCPRLSRELLEVVAPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKH 1305

Query: 1089 VGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVL 1148
            VGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ + PEVL
Sbjct: 1306 VGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVL 1364

Query: 1149 QDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            QDSLDRCYSTPS   EL DS Q YRS FY  E+Q +  A+D+D
Sbjct: 1365 QDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGMAVDMD 1407



 Score =  637 bits (1643), Expect = 0.0
 Identities = 456/1078 (42%), Positives = 564/1078 (52%), Gaps = 152/1078 (14%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 1161 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 1220

Query: 226  NINITFEEDKVNSTLVVDR---ESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS- 281
            +   + EE  +   L VDR   +   +E QD       P P  S   + +V       S 
Sbjct: 1221 SAVYSLEEQYLGLALDVDRIKKDEEEEEDQDP------PCPRLSRELLEVVAPEVLQDSL 1274

Query: 282  ---EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLI 338
                    + LE  +  +P        F  L+EK       GF  +        E E   
Sbjct: 1275 DRCYSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKG 1319

Query: 339  KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHL 398
            K   R  R+ K+E+   + K+ EE +       S+E    +  E L++  D   S     
Sbjct: 1320 KGKKRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGC 1378

Query: 399  QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSA 458
              L    +P +S    L++Q             ++    D DE E  Q  E E+  + S 
Sbjct: 1379 LELTDSCQPYRSAFYVLEQQ-------------RVGMAVDMDEIEKYQ--EVEEDQDPSC 1423

Query: 459  PR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDR 515
            PR   E+   +E +V +DSL  C  T S      D  QP+ +   + EE  +  AL VDR
Sbjct: 1424 PRLSRELLDEKEPEVLQDSLNRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDR 1483

Query: 516  -----ESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQL 570
                 E   DE QD       P P  S                       E+ E + P++
Sbjct: 1484 IKKDQEEEEDEDQDP------PCPRLSR----------------------ELLEVVEPEV 1515

Query: 571  AEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQ 630
             +         ++C+ T  +C            E  D  +    +    +E  +   L  
Sbjct: 1516 LQDSL------DRCYSTPSSCL-----------EQPDSCQPYGSSFYALEENHVGFSLDV 1558

Query: 631  AEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE-- 688
             E  ++ K       R   + R   +EG +        L   L  ++  +     L    
Sbjct: 1559 GEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCY 1618

Query: 689  -------QLAEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQK 735
                   +L + C+  +  F  L  ++     D DE  + +  E+ Q  S PR   E+  
Sbjct: 1619 STPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLD 1678

Query: 736  AEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAV 795
             +E EV +DSL+ C  T S      D  QP+     + EE  +   L             
Sbjct: 1679 EKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD------------ 1726

Query: 796  HIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSY 852
              +   + D EEEE++GP  PR    L E  E EV Q+S D  YST S   E   S Q Y
Sbjct: 1727 --VDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY 1784

Query: 853  SGTFHSLEEQQVCMAVDIG------------GHRWDQVKK-------EDQEATGPRLSRE 893
              +F++LEE  V  ++D+G            G R  + ++       EDQ    PRLSRE
Sbjct: 1785 GSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRE 1844

Query: 894  LLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQE 953
            LLDEKGPEVLQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQ VG A+DMDEIEKYQE
Sbjct: 1845 LLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQE 1904

Query: 954  VEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQY 1013
            VEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQY
Sbjct: 1905 VEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQY 1964

Query: 1014 LGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDS 1073
            LGLALDVDRIKKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDS
Sbjct: 1965 LGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDS 2024

Query: 1074 CLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCP 1133
            C PYGSSFYALEE HVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCP
Sbjct: 2025 CQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCP 2083

Query: 1134 RLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            RLS  L++ + PEVLQDSLDRCYSTPS   EL DS Q YRS FY  E+QH+  A+D+D
Sbjct: 2084 RLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMD 2141



 Score =  635 bits (1638), Expect = 0.0
 Identities = 453/1100 (41%), Positives = 573/1100 (52%), Gaps = 149/1100 (13%)

Query: 147  QLAEGC---RLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR---EVQKAEESKVP 200
            +L + C   R A +++++       D DE  + +E E+  + S PR   E+   +E +V 
Sbjct: 1380 ELTDSCQPYRSAFYVLEQQRVGMAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVL 1439

Query: 201  EDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDR-----ESSHDECQDAV 255
            +DSL  C  T S      D  QP+ +   + EE  +   L VDR     E   DE QD  
Sbjct: 1440 QDSLNRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDEDQDP- 1498

Query: 256  NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFV 315
               P P                 LS E  E+   E+ +    +            + C  
Sbjct: 1499 ---PCPR----------------LSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSC-Q 1538

Query: 316  TQLAGFLANQQNKYKYE----ECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVH 371
               + F A ++N   +     E E   K   R  R+ K+E+   + K+ EE +       
Sbjct: 1539 PYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGR-KEGEEDQNPPCPRL 1597

Query: 372  SQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQ 431
            S+E    +  E L++  D   S       L    +P +S    L++Q         H+  
Sbjct: 1598 SRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ---------HVGL 1648

Query: 432  KLSPENDEDEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGP 488
             +      D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S     
Sbjct: 1649 AV------DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLEL 1702

Query: 489  CDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAG 548
             D  QP+ +   + EE  +  AL VDR     E ++                       G
Sbjct: 1703 PDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEE---------------------DQG 1741

Query: 549  PLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDL 608
            P     +     E+ E + P++ +         ++C+ T  +C            E  D 
Sbjct: 1742 PPCPRLSR----ELLEVVEPEVLQDSL------DRCYSTPSSCL-----------EQPDS 1780

Query: 609  IKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQH 668
             +    +    +E  +   L   E  ++ K       R   + R   +EG +        
Sbjct: 1781 CQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPR 1840

Query: 669  LQALLTPDEPDKSQGQDLQE---------QLAEGCRLAQQLFQKLSPENDN---DHDEDV 716
            L   L  ++  +     L           +L + C+  +  F  L  ++     D DE  
Sbjct: 1841 LSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIE 1900

Query: 717  QVEVAEKVQKSSAPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITF 773
            + +  E+ Q  S PR   E+   +E EV +DSL+ C  T S      D  QP+     + 
Sbjct: 1901 KYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSL 1960

Query: 774  EEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQE 830
            EE  +   L               +   + D EEEE++GP  PR    L E  E EV Q+
Sbjct: 1961 EEQYLGLALD--------------VDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQD 2006

Query: 831  SWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIG------------GHRWDQV 878
            S D  YST S   E   S Q Y  +F++LEE  V  ++D+G            G R  + 
Sbjct: 2007 SLDRCYSTPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKE 2066

Query: 879  KK-------EDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAF 931
            ++       EDQ    PRLSRELLDEKGPEVLQDSLDRCYSTPSG LELTDSCQPYRSAF
Sbjct: 2067 RRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAF 2126

Query: 932  YILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG 991
            Y+LEQQ VG A+DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG
Sbjct: 2127 YVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG 2186

Query: 992  YLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPE 1051
            YLELPDLGQPY SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLE VEPE
Sbjct: 2187 YLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPE 2246

Query: 1052 VLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR 1111
            VLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALEE HVGFSLDVGEIEKKGKGKKRRGRR
Sbjct: 2247 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRR 2306

Query: 1112 STKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQH 1171
            S KK RRRGRKEGEEDQNPPCPRLS  L++ + PEVLQDSLDRCYSTPS   EL DS Q 
Sbjct: 2307 S-KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQP 2365

Query: 1172 YRSVFYSFEEQHISFALDVD 1191
            YRS FY  E+QH+  A+D+D
Sbjct: 2366 YRSAFYVLEQQHVGLAVDMD 2385



 Score =  634 bits (1636), Expect = 0.0
 Identities = 446/1070 (41%), Positives = 562/1070 (52%), Gaps = 138/1070 (12%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 1895 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 1954

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAE 285
            +   + EE  +   L VDR     E ++        GP               LS E  E
Sbjct: 1955 SAVYSLEEQYLGLALDVDRIKKDQEEEED------QGPPCPR-----------LSRELLE 1997

Query: 286  MNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYE----ECEDLIKSM 341
            +   E+ +    +            + C     + F A ++N   +     E E   K  
Sbjct: 1998 VVEPEVLQDSLDRCYSTPSSCLEQPDSC-QPYGSSFYALEENHVGFSLDVGEIEKKGKGK 2056

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D   S       L
Sbjct: 2057 KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL 2115

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q         H+   +      D DE  + +E E+  + S PR 
Sbjct: 2116 TDSCQPYRSAFYVLEQQ---------HVGLAV------DMDEIEKYQEVEEDQDPSCPRL 2160

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 2161 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKK 2220

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 578
              E ++                       GP     +     E+ E + P++ +      
Sbjct: 2221 DQEEEE---------------------DQGPPCPRLSR----ELLEVVEPEVLQDSL--- 2252

Query: 579  NLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
               ++C+ T  +C            E  D  +    +    +E  +   L   E  ++ K
Sbjct: 2253 ---DRCYSTPSSCL-----------EQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGK 2298

Query: 639  VLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE---------Q 689
                   R   + R   +EG +        L   L  ++  +     L           +
Sbjct: 2299 GKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLE 2358

Query: 690  LAEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPE 743
            L + C+  +  F  L  ++     D DE  + +  E+ Q  S PR   E+   +E EV +
Sbjct: 2359 LTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQ 2418

Query: 744  DSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENES 803
            DSL+ C  T S      D  QP+     + EE  +   L               +   + 
Sbjct: 2419 DSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------------VDRIKK 2464

Query: 804  DDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLE 860
            D EEEE++GP  PR    L E  E EV Q+S D  YST S   E   S Q Y  +F++LE
Sbjct: 2465 DQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALE 2524

Query: 861  EQQVCMAVDIG------------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPE 901
            E  V  ++D+G            G R  + ++       EDQ    PRLSRELLDEKGPE
Sbjct: 2525 ENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPE 2584

Query: 902  VLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPS 961
            VLQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQ VG A+DMDEIEKYQEVEEDQDPS
Sbjct: 2585 VLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPS 2644

Query: 962  CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 1021
            CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVD
Sbjct: 2645 CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 2704

Query: 1022 RIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSF 1081
            RIKKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSF
Sbjct: 2705 RIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSF 2764

Query: 1082 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLME 1141
            YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++
Sbjct: 2765 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLD 2823

Query: 1142 VEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
             + PEVLQDSLDRCYSTPS   EL DS Q YRS FY  E+QH+  A+D+D
Sbjct: 2824 EKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMD 2873



 Score =  629 bits (1623), Expect = e-180
 Identities = 444/1070 (41%), Positives = 562/1070 (52%), Gaps = 138/1070 (12%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 2139 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 2198

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAE 285
            +   + EE  +   L VDR     E ++        GP               LS E  E
Sbjct: 2199 SAVYSLEEQYLGLALDVDRIKKDQEEEED------QGPPCPR-----------LSRELLE 2241

Query: 286  MNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYE----ECEDLIKSM 341
            +   E+ +    +            + C     + F A ++N   +     E E   K  
Sbjct: 2242 VVEPEVLQDSLDRCYSTPSSCLEQPDSC-QPYGSSFYALEENHVGFSLDVGEIEKKGKGK 2300

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D   S       L
Sbjct: 2301 KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL 2359

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q         H+   +      D DE  + +E E+  + S PR 
Sbjct: 2360 TDSCQPYRSAFYVLEQQ---------HVGLAV------DMDEIEKYQEVEEDQDPSCPRL 2404

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 2405 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKK 2464

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 578
              E ++                       GP     +     E+ E + P++ +      
Sbjct: 2465 DQEEEE---------------------DQGPPCPRLSR----ELLEVVEPEVLQDSL--- 2496

Query: 579  NLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
               ++C+ T  +C            E  D  +    +    +E  +   L   E  ++ K
Sbjct: 2497 ---DRCYSTPSSCL-----------EQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGK 2542

Query: 639  VLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE---------Q 689
                   R   + R   +EG +        L   L  ++  +     L           +
Sbjct: 2543 GKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLE 2602

Query: 690  LAEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPE 743
            L + C+  +  F  L  ++     D DE  + +  E+ Q  S PR   E+   +E EV +
Sbjct: 2603 LTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQ 2662

Query: 744  DSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENES 803
            DSL+ C  T S      D  QP+     + EE  +   L               +   + 
Sbjct: 2663 DSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------------VDRIKK 2708

Query: 804  DDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLE 860
            D EEEE++GP  PR    L E  E EV Q+S D  YST S   E   S Q Y  +F++LE
Sbjct: 2709 DQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALE 2768

Query: 861  EQQVCMAVDIG------------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPE 901
            E+ V  ++D+G            G R  + ++       EDQ    PRLSRELLDEKGPE
Sbjct: 2769 EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPE 2828

Query: 902  VLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPS 961
            VLQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQ VG A+DMDEIEKYQEVEEDQDPS
Sbjct: 2829 VLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPS 2888

Query: 962  CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 1021
            CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVD
Sbjct: 2889 CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 2948

Query: 1022 RIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSF 1081
            RIKKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSF
Sbjct: 2949 RIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSF 3008

Query: 1082 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLME 1141
            YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++
Sbjct: 3009 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLD 3067

Query: 1142 VEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
             + P+VLQDSLDRCYSTPS   EL DS Q YRS FY  E+Q +  A+D+D
Sbjct: 3068 EKGPKVLQDSLDRCYSTPSGCLELCDSCQPYRSAFYVLEQQRVGLAVDMD 3117



 Score =  629 bits (1621), Expect = e-180
 Identities = 458/1098 (41%), Positives = 583/1098 (53%), Gaps = 119/1098 (10%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 2383 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 2442

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAE 285
            +   + EE  +   L VDR     E ++        GP               LS E  E
Sbjct: 2443 SAVYSLEEQYLGLALDVDRIKKDQEEEED------QGPPCPR-----------LSRELLE 2485

Query: 286  MNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYE----ECEDLIKSM 341
            +   E+ +    +            + C     + F A ++N   +     E E   K  
Sbjct: 2486 VVEPEVLQDSLDRCYSTPSSCLEQPDSC-QPYGSSFYALEENHVGFSLDVGEIEKKGKGK 2544

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D   S       L
Sbjct: 2545 KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL 2603

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q         H+   +      D DE  + +E E+  + S PR 
Sbjct: 2604 TDSCQPYRSAFYVLEQQ---------HVGLAV------DMDEIEKYQEVEEDQDPSCPRL 2648

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 2649 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKK 2708

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS----EKAEMNILEMNEKLRPQLAEKK 574
              E ++       P P  S   + +V       S         + LE  +  +P      
Sbjct: 2709 DQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY----G 2761

Query: 575  QQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEE------KLAEQL 628
              F  L+EK     L      ++ K K    +   K   R  ++ +E+      +L+ +L
Sbjct: 2762 SSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSREL 2821

Query: 629  ---KQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQ-HLQALLTPDEPDKSQGQ 684
               K  E L+      +S      +L +  +  R A   L Q H+   +  DE +K Q  
Sbjct: 2822 LDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQ-- 2879

Query: 685  DLQEQLAEGC-RLAQQLFQKLSPENDNDH------------------------------- 712
            +++E     C RL+++L  +  PE   D                                
Sbjct: 2880 EVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQ 2939

Query: 713  ------DEDVQVEVAEKVQKSSAP-----REMQKAEEKEVPEDSLEECAITCSNSHGPYD 761
                  D D   +  E+ +    P     RE+ +  E EV +DSL+ C  T S+     D
Sbjct: 2940 YLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPD 2999

Query: 762  SNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSP 816
            S QP+  +    EE  V  +L       + +        ++ +      E EE++ P  P
Sbjct: 3000 SCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCP 3059

Query: 817  RNLQESEEEEVP---QESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGH 873
            R  +E  +E+ P   Q+S D  YST S   E+  S Q Y   F+ LE+Q+V +AVD+   
Sbjct: 3060 RLSRELLDEKGPKVLQDSLDRCYSTPSGCLELCDSCQPYRSAFYVLEQQRVGLAVDMDEI 3119

Query: 874  RWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYI 933
               Q  +EDQ+ + PRLSRELLDEKGPEVLQDSLDRCYSTPSG LEL DSCQPYRSAFYI
Sbjct: 3120 EKYQEVEEDQDPSCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELCDSCQPYRSAFYI 3179

Query: 934  LEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYL 993
            LEQQRVG A+DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYL
Sbjct: 3180 LEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYL 3239

Query: 994  ELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVL 1053
            ELPDLGQPY SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLE VEPEVL
Sbjct: 3240 ELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVL 3299

Query: 1054 QDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRST 1113
            QDSLDRCYSTPSSCLEQPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS 
Sbjct: 3300 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS- 3358

Query: 1114 KKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYR 1173
            KK RRRGRKEGEEDQNPPCPRLS  L++ + PEVLQDSLDRCYSTPS   EL DS Q YR
Sbjct: 3359 KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELCDSCQPYR 3418

Query: 1174 SVFYSFEEQHISFALDVD 1191
            S FY  E+QH+  A+D+D
Sbjct: 3419 SAFYVLEQQHVGLAVDMD 3436



 Score =  620 bits (1600), Expect = e-177
 Identities = 446/1072 (41%), Positives = 561/1072 (52%), Gaps = 140/1072 (13%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 673  DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 732

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 733  SAVYSLEEQYLGLALDVDRIKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 789

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 790  YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 834

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D   S       L
Sbjct: 835  KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL 893

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q             ++    D DE E  Q  E E+  + S PR 
Sbjct: 894  TDSCQPYRSAFYVLEQQ-------------RVGFAVDMDEIEKYQ--EVEEDQDPSCPRL 938

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 939  SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKK 998

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 578
              E ++                       GP     +     E+ E + P++ +      
Sbjct: 999  DQEEEE---------------------DQGPPCPRLSR----ELLEVVEPEVLQDSL--- 1030

Query: 579  NLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
               ++C+ T  +C            E  D  +    +    +E+ +   L   E  ++ K
Sbjct: 1031 ---DRCYSTPSSCL-----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGK 1076

Query: 639  VLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE---------Q 689
                   R   + R   +EG +        L   L  ++  +     L           +
Sbjct: 1077 GKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLE 1136

Query: 690  LAEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPE 743
            L + C+  +  F  L  +      D DE  + +  E+ Q  S PR   E+   +E EV +
Sbjct: 1137 LTDSCQPYRSAFYVLEQQRVGFAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQ 1196

Query: 744  DSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENES 803
            DSL+ C  T S      D  QP+     + EE  +   L               +   + 
Sbjct: 1197 DSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------------VDRIKK 1242

Query: 804  DDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLE 860
            D+EEEE++ P  PR    L E    EV Q+S D  YST S   E   S Q Y  +F++LE
Sbjct: 1243 DEEEEEDQDPPCPRLSRELLEVVAPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALE 1302

Query: 861  EQQVCMAVDIG------------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPE 901
            E+ V  ++D+G            G R  + ++       EDQ    PRLSRELLDEKGPE
Sbjct: 1303 EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPE 1362

Query: 902  VLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPS 961
            VLQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPS
Sbjct: 1363 VLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGMAVDMDEIEKYQEVEEDQDPS 1422

Query: 962  CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 1021
            CPRLSRELLDEKEPEVLQDSL+RCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVD
Sbjct: 1423 CPRLSRELLDEKEPEVLQDSLNRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 1482

Query: 1022 RIKKDQEEE--EDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGS 1079
            RIKKDQEEE  EDQ PPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGS
Sbjct: 1483 RIKKDQEEEEDEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGS 1542

Query: 1080 SFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGML 1139
            SFYALEE HVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L
Sbjct: 1543 SFYALEENHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSREL 1601

Query: 1140 MEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            ++ + PEVLQDSLDRCYSTPS   EL DS Q YRS FY  E+QH+  A+D+D
Sbjct: 1602 LDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMD 1653



 Score =  586 bits (1511), Expect = e-167
 Identities = 433/1093 (39%), Positives = 564/1093 (51%), Gaps = 138/1093 (12%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 2627 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 2686

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 2687 SAVYSLEEQYLGLALDVDRIKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 2743

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 2744 YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 2788

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D   S       L
Sbjct: 2789 KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL 2847

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q         H+   +      D DE  + +E E+  + S PR 
Sbjct: 2848 TDSCQPYRSAFYVLEQQ---------HVGLAV------DMDEIEKYQEVEEDQDPSCPRL 2892

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 2893 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKK 2952

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 578
              E ++                       GP     +     E+ E + P++ +      
Sbjct: 2953 DQEEEE---------------------DQGPPCPRLSR----ELLEVVEPEVLQDSL--- 2984

Query: 579  NLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
               ++C+ T  +C            E  D  +    +    +E+ +   L   E  ++ K
Sbjct: 2985 ---DRCYSTPSSCL-----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGK 3030

Query: 639  VLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE---------Q 689
                   R   + R   +EG +        L   L  ++  K     L           +
Sbjct: 3031 GKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPKVLQDSLDRCYSTPSGCLE 3090

Query: 690  LAEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPE 743
            L + C+  +  F  L  +      D DE  + +  E+ Q  S PR   E+   +  EV +
Sbjct: 3091 LCDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKGPEVLQ 3150

Query: 744  DSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENES 803
            DSL+ C  T S      DS QP+R      E+ +V   +               + E E 
Sbjct: 3151 DSLDRCYSTPSGCLELCDSCQPYRSAFYILEQQRVGLAVD--------------MDEIEK 3196

Query: 804  DDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLE 860
              E EE++ P  PR    L + +E EV Q+S D  YST S   E+    Q YS   +SLE
Sbjct: 3197 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 3256

Query: 861  EQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLEL 920
            EQ + +A+D+   + DQ ++EDQ    PRLSRELL+   PEVLQDSLDRCYSTPS  LE 
Sbjct: 3257 EQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQ 3316

Query: 921  TDSCQPYRSAFYILEQQRVGWALDMDEIEKY-------------------QEVEEDQDPS 961
             DSCQPY S+FY LE++ VG++LD+ EIEK                    +E EEDQ+P 
Sbjct: 3317 PDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPP 3376

Query: 962  CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 1021
            CPRLSRELLDEK PEVLQDSLDRCYSTPSG LEL D  QPYRSA Y LE+Q++GLA+D+D
Sbjct: 3377 CPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELCDSCQPYRSAFYVLEQQHVGLAVDMD 3436

Query: 1022 RIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSF 1081
             I+K QE EEDQ P CPRLSRELL+  EPEVLQDSLDRCYSTPS  LE PD   PY S+ 
Sbjct: 3437 EIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAV 3496

Query: 1082 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLME 1141
            Y+LEE+++G +LDV +IEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRL+G+LME
Sbjct: 3497 YSLEEQYLGLALDVDKIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLNGVLME 3555

Query: 1142 VEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVDNRFLTLMGTS 1201
            VEE EVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFAL VDNRF TL  TS
Sbjct: 3556 VEEREVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTS 3615

Query: 1202 LHLVFQMGVIFPQ 1214
            LHLVFQMGVIFPQ
Sbjct: 3616 LHLVFQMGVIFPQ 3628



 Score =  447 bits (1151), Expect = e-125
 Identities = 392/1173 (33%), Positives = 542/1173 (46%), Gaps = 190/1173 (16%)

Query: 90   EELRQYKVLVHSQERELTQLREKLREGRDAS---RSLNQHLQA----LLTPD--EPDKSQ 140
            +E+ +Y+ +   Q+    +L  +L + ++      SLN+        L  PD  +P  S 
Sbjct: 1407 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLNRCYSTPSGYLELPDLGQPYSSA 1466

Query: 141  GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVP 200
               L+EQ   G  L    ++K   E +EDED+D               RE+ +  E +V 
Sbjct: 1467 VYSLEEQYL-GLALDVDRIKK-DQEEEEDEDQDPPCPRLS--------RELLEVVEPEVL 1516

Query: 201  EDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVV-------------DRESS 247
            +DSL+ C  T S+     DS QP+ +     EE+ V  +L V              R S 
Sbjct: 1517 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSK 1576

Query: 248  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSE-------KAEMNILEMNEKLRPQLA 300
             +  +          P     +  ++   GP   +             LE+ +  +P   
Sbjct: 1577 KERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPY-- 1634

Query: 301  EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEEC-EDLIKSMLRNERQFKEEKLAEQLKQ 359
              +  F  L++     Q  G   +     KY+E  ED   S  R  R+  +EK  E L+ 
Sbjct: 1635 --RSAFYVLEQ-----QHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQD 1687

Query: 360  AEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQL 419
            + + R Y     S   EL  L                         +P  S    L+EQ 
Sbjct: 1688 SLD-RCYS--TPSGYLELPDL------------------------GQPYSSAVYSLEEQY 1720

Query: 420  AEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECA 479
              G  L    V ++  + +E+ED+                RE+ +  E +V +DSL+ C 
Sbjct: 1721 L-GLALD---VDRIKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVLQDSLDRCY 1768

Query: 480  ITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSAT 539
             T S+     DS QP+ +     EE+ V  +L V       +           G      
Sbjct: 1769 STPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGK-----------GKKRRGR 1817

Query: 540  NVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKK--QQFRNLKEKCFVTQLACFLANQQ 597
                    G    E+ +        +L  +L ++K  +  ++  ++C+ T   C      
Sbjct: 1818 RSKKERRRGRKEGEEDQN---PPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELT-- 1872

Query: 598  NKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQE-------RELTQ 650
                 + C+       R+     E++        +E+ +Y+ +   Q+       REL  
Sbjct: 1873 -----DSCQP-----YRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLD 1922

Query: 651  LREK--LREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPEN 708
             +E   L++  D   S       L    +P  S    L+EQ   G  L     +K     
Sbjct: 1923 EKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL-GLALDVDRIKK----- 1976

Query: 709  DNDHDEDVQVEVAEKVQKSSAP---REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQP 765
            D + +ED         Q    P   RE+ +  E EV +DSL+ C  T S+     DS QP
Sbjct: 1977 DQEEEED---------QGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQP 2027

Query: 766  HRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPRNLQ 820
            +  +    EE+ V  +L       + +        ++ +      E EE++ P  PR  +
Sbjct: 2028 YGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSR 2087

Query: 821  ESEEE---EVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQ 877
            E  +E   EV Q+S D  YST S   E+  S Q Y   F+ LE+Q V +AVD+      Q
Sbjct: 2088 ELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQ 2147

Query: 878  VKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQ 937
              +EDQ+ + PRLSRELLDEK PEVLQDSLDRCYSTPSGYLEL D  QPY SA Y LE+Q
Sbjct: 2148 EVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQ 2207

Query: 938  RVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPD 997
             +G ALD+D I+K QE EEDQ P CPRLSRELL+  EPEVLQDSLDRCYSTPS  LE PD
Sbjct: 2208 YLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPD 2267

Query: 998  LGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEEEEDQGPPCP 1038
              QPY S+ Y+LEE ++G +LDV  I+K                    +E EEDQ PPCP
Sbjct: 2268 SCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCP 2327

Query: 1039 RLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEI 1098
            RLSRELL+   PEVLQDSLDRCYSTPS CLE  DSC PY S+FY LE++HVG ++D+ EI
Sbjct: 2328 RLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEI 2387

Query: 1099 EKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYST 1158
            EK                     +E EEDQ+P CPRLS  L++ +EPEVLQDSLDRCYST
Sbjct: 2388 EK--------------------YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYST 2427

Query: 1159 PSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            PS Y ELPD  Q Y S  YS EEQ++  ALDVD
Sbjct: 2428 PSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 2460



 Score =  404 bits (1038), Expect = e-112
 Identities = 354/1085 (32%), Positives = 489/1085 (45%), Gaps = 188/1085 (17%)

Query: 90   EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPD---------EPDKSQ 140
            +E+ +Y+ +   Q+    +L  +L + ++     +   +   TP          +P  S 
Sbjct: 2629 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 2688

Query: 141  GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVP 200
               L+EQ   G  L    V ++  + +E+ED+                RE+ +  E +V 
Sbjct: 2689 VYSLEEQYL-GLALD---VDRIKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVL 2736

Query: 201  EDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVV-------------DRESS 247
            +DSL+ C  T S+     DS QP+ +     EE  V  +L V              R S 
Sbjct: 2737 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSK 2796

Query: 248  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSE-------KAEMNILEMNEKLRPQLA 300
             +  +          P     +  ++   GP   +             LE+ +  +P   
Sbjct: 2797 KERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPY-- 2854

Query: 301  EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEEC-EDLIKSMLRNERQFKEEKLAEQLKQ 359
              +  F  L++     Q  G   +     KY+E  ED   S  R  R+  +EK  E L+ 
Sbjct: 2855 --RSAFYVLEQ-----QHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQD 2907

Query: 360  AEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQL 419
            + + R Y     S   EL  L                         +P  S    L+EQ 
Sbjct: 2908 SLD-RCYS--TPSGYLELPDL------------------------GQPYSSAVYSLEEQY 2940

Query: 420  AEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECA 479
              G  L    V ++  + +E+ED+                RE+ +  E +V +DSL+ C 
Sbjct: 2941 L-GLALD---VDRIKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVLQDSLDRCY 2988

Query: 480  ITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSAT 539
             T S+     DS QP+ +     EE  V  +L V       +           G      
Sbjct: 2989 STPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGK-----------GKKRRGR 3037

Query: 540  NVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKK--QQFRNLKEKCFVTQLACFLANQQ 597
                    G    E+ +        +L  +L ++K  +  ++  ++C+ T   C      
Sbjct: 3038 RSKKERRRGRKEGEEDQN---PPCPRLSRELLDEKGPKVLQDSLDRCYSTPSGCL----- 3089

Query: 598  NKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLRE 657
                 E C        R+     E++        +E+ +Y+ +   Q+    +L  +L +
Sbjct: 3090 -----ELCDSC--QPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLD 3142

Query: 658  GRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDN---DHDE 714
             +      +   +   TP             +L + C+  +  F  L  +      D DE
Sbjct: 3143 EKGPEVLQDSLDRCYSTPSG---------CLELCDSCQPYRSAFYILEQQRVGLAVDMDE 3193

Query: 715  DVQVEVAEKVQKSSAP---REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKI 771
              + +  E+ Q  S P   RE+   +E EV +DSL+ C  T S      D  QP+     
Sbjct: 3194 IEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVY 3253

Query: 772  TFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSP---RNLQESEEEEVP 828
            + EE  +   L               +   + D EEEE++GP  P   R L E  E EV 
Sbjct: 3254 SLEEQYLGLAL--------------DVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVL 3299

Query: 829  QESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIG------------GHRWD 876
            Q+S D  YST S   E   S Q Y  +F++LEE+ V  ++D+G            G R  
Sbjct: 3300 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSK 3359

Query: 877  QVKK-------EDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRS 929
            + ++       EDQ    PRLSRELLDEKGPEVLQDSLDRCYSTPSG LEL DSCQPYRS
Sbjct: 3360 KERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELCDSCQPYRS 3419

Query: 930  AFYILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTP 989
            AFY+LEQQ VG A+DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTP
Sbjct: 3420 AFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTP 3479

Query: 990  SGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEEE 1030
            SGYLELPDLGQPY SAVYSLEEQYLGLALDVD+I+K                    +E E
Sbjct: 3480 SGYLELPDLGQPYSSAVYSLEEQYLGLALDVDKIEKKGKGKKRRGRRSKKERRRGRKEGE 3539

Query: 1031 EDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVG 1090
            EDQ PPCPRL+  L+E  E EVLQDSLDRCYSTPS   E PDS   Y S FY+ EE+H+ 
Sbjct: 3540 EDQNPPCPRLNGVLMEVEEREVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHIS 3599

Query: 1091 FSLDV 1095
            F+L V
Sbjct: 3600 FALYV 3604


>gi|239741309 PREDICTED: hypothetical protein XP_002344485 [Homo
            sapiens]
          Length = 4621

 Score = 1694 bits (4386), Expect = 0.0
 Identities = 851/920 (92%), Positives = 874/920 (95%), Gaps = 1/920 (0%)

Query: 272  MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKY 331
            MVVSAGP SSEKAEMNILE+NEKLRPQLAE KQQF NLKE+CFVTQLAGFLANQQ KY Y
Sbjct: 1    MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFGNLKERCFVTQLAGFLANQQKKYNY 60

Query: 332  EECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 391
            EEC+DLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120

Query: 392  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 451
            RSLN+HLQALLT DEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE
Sbjct: 121  RSLNEHLQALLTLDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180

Query: 452  KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL 511
            KV +SSAPREVQK EESKVPEDSLEECAITCSNSHGPCDSNQPHKNI ITFEED+VNS L
Sbjct: 181  KVQKSSAPREVQKTEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL 240

Query: 512  VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 571
            VVDRESSHDECQDA+NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILE+NEKL PQLA
Sbjct: 241  VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLA 300

Query: 572  EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQA 631
            EKKQQFRNLKE+CFVTQLA FLANQQ KYKYEECKDLIKS+LRNERQFKEEKLAEQLKQA
Sbjct: 301  EKKQQFRNLKERCFVTQLAGFLANQQKKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQA 360

Query: 632  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 691
            EELRQYKVLVH+QERELTQLREKLREGRDASRSLN+HLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 361  EELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 420

Query: 692  EGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI 751
            EGCRLAQ L QKLSPENDND DEDVQVE+AEKVQKSSAPREMQKAEEKEVPEDS EECAI
Sbjct: 421  EGCRLAQHLVQKLSPENDNDDDEDVQVELAEKVQKSSAPREMQKAEEKEVPEDSQEECAI 480

Query: 752  TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEK 811
            T SNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEK
Sbjct: 481  TYSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEK 540

Query: 812  GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIG 871
            GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYS TFHSLEEQQVCMAVDIG
Sbjct: 541  GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIG 600

Query: 872  GHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAF 931
             HRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSG LELTDSCQPYRSAF
Sbjct: 601  RHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAF 660

Query: 932  YILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG 991
            Y+LEQQR+G A+DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG
Sbjct: 661  YVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSG 720

Query: 992  YLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPE 1051
            YLELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLE VEPE
Sbjct: 721  YLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPE 780

Query: 1052 VLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR 1111
            VLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR
Sbjct: 781  VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR 840

Query: 1112 STKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQH 1171
            S KK RRRGRKEGEEDQNPPCPRLS  L++ + PEVLQDSLDR YSTPS   EL DS Q 
Sbjct: 841  S-KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQP 899

Query: 1172 YRSVFYSFEEQHISFALDVD 1191
            YRS FY  E+Q +  A+D+D
Sbjct: 900  YRSAFYVLEQQRVGLAVDMD 919



 Score = 1531 bits (3963), Expect = 0.0
 Identities = 843/1226 (68%), Positives = 923/1226 (75%), Gaps = 98/1226 (7%)

Query: 1    MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
            MVVSAGPWSSEKAE NILEINEKLRPQLAENKQQF NLKE+CFVTQLAGFLAN+QKKY Y
Sbjct: 1    MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFGNLKERCFVTQLAGFLANQQKKYNY 60

Query: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
            EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120

Query: 121  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
            RSLN+HLQALLT DEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE
Sbjct: 121  RSLNEHLQALLTLDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180

Query: 181  KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
            KV +SSAPREVQK EESKVPEDSLEECAITCSNSHGPCDSNQPHKNI ITFEED+VNSTL
Sbjct: 181  KVQKSSAPREVQKTEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL 240

Query: 241  VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 300
            VVDRESSHDECQDA+NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILE+NEKL PQLA
Sbjct: 241  VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLA 300

Query: 301  EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA 360
            EKKQQFRNLKE+CFVTQLAGFLANQQ KYKYEEC+DLIKSMLRNERQFKEEKLAEQLKQA
Sbjct: 301  EKKQQFRNLKERCFVTQLAGFLANQQKKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQA 360

Query: 361  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420
            EELRQYKVLVH+QERELTQLREKLREGRDASRSLN+HLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 361  EELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 420

Query: 421  EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAI 480
            EGCRLAQHLVQKLSPEND D+DEDVQVE AEKV +SSAPRE+QKAEE +VPEDS EECAI
Sbjct: 421  EGCRLAQHLVQKLSPENDNDDDEDVQVELAEKVQKSSAPREMQKAEEKEVPEDSQEECAI 480

Query: 481  TCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILP---------- 530
            T SNSHGP DSNQPH+   ITFEEDKV+S L+    SSH E +DAV+I+P          
Sbjct: 481  TYSNSHGPYDSNQPHRKTKITFEEDKVDSTLI--GSSSHVEWEDAVHIIPENESDDEEEE 538

Query: 531  VPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLA 590
              GP S            P  S     + L +  ++          F +L+E     Q  
Sbjct: 539  EKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEE-----QQV 593

Query: 591  CFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ 650
            C +A    ++++++ K             KE++ A   + + EL   K            
Sbjct: 594  C-MAVDIGRHRWDQVK-------------KEDQEATGPRLSRELLDEKG----------- 628

Query: 651  LREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDN 710
              E L++  D   S       L    +P +S    L++Q     R+   +          
Sbjct: 629  -PEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ-----RIGLAV---------- 672

Query: 711  DHDEDVQVEVAEKVQKSSAP---REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHR 767
            D DE  + +  E+ Q  S P   RE+   +E EV +DSL+ C  T S      D  QP+ 
Sbjct: 673  DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 732

Query: 768  KTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSP---RNLQESEE 824
                + EE  +   L               +   + D EEEE++GP  P   R L E  E
Sbjct: 733  SAVYSLEEQYLGLAL--------------DVDRTKKDQEEEEDQGPPCPRLSRELLEVVE 778

Query: 825  EEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIG------------G 872
             EV Q+S D  YST S   E   S Q Y  +F++LEE+ V  ++D+G            G
Sbjct: 779  PEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRG 838

Query: 873  HRWDQVKK-------EDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQ 925
             R  + ++       EDQ    PRLSRELLDEKGPEVLQDSLDR YSTPSG LELTDSCQ
Sbjct: 839  RRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQ 898

Query: 926  PYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRC 985
            PYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRC
Sbjct: 899  PYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRC 958

Query: 986  YSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL 1045
            YSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELL
Sbjct: 959  YSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELL 1018

Query: 1046 EAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGK 1105
            E VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKGK
Sbjct: 1019 EVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGK 1078

Query: 1106 KRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFEL 1165
            KRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ + PEVLQDSLDRCYSTPS   EL
Sbjct: 1079 KRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL 1137

Query: 1166 PDSFQHYRSVFYSFEEQHISFALDVD 1191
             DS Q YRS FY  E+Q +  A+D+D
Sbjct: 1138 TDSCQPYRSAFYVLEQQRVGLAVDMD 1163



 Score = 1031 bits (2667), Expect = 0.0
 Identities = 642/1235 (51%), Positives = 760/1235 (61%), Gaps = 143/1235 (11%)

Query: 1    MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
            MVVSAGP SSEKAE NILEINEKL PQLAE KQQFRNLKE+CFVTQLAGFLAN+QKKYKY
Sbjct: 272  MVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKERCFVTQLAGFLANQQKKYKY 331

Query: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
            EECKDLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDAS
Sbjct: 332  EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDAS 391

Query: 121  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
            RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE AE
Sbjct: 392  RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVELAE 451

Query: 181  KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
            KV +SSAPRE+QKAEE +VPEDS EECAIT SNSHGP DSNQPH+   ITFEEDKV+STL
Sbjct: 452  KVQKSSAPREMQKAEEKEVPEDSQEECAITYSNSHGPYDSNQPHRKTKITFEEDKVDSTL 511

Query: 241  VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 300
            +    SSH E +DAV+I+P      + ++       GP+S      N+ E  E+  PQ +
Sbjct: 512  I--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQES 560

Query: 301  -EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEE---CEDLIKSMLRNERQFKEEKLAEQ 356
             ++     ++  +     LA + +     +  EE   C  +     R ++  KE++ A  
Sbjct: 561  WDEGYSTLSIPPE----MLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATG 616

Query: 357  LKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQ 416
             + + EL   K              E L++  D   S       L    +P +S    L+
Sbjct: 617  PRLSRELLDEKG------------PEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLE 664

Query: 417  EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPED 473
            +Q             ++    D DE E  Q  E E+  + S PR   E+   +E +V +D
Sbjct: 665  QQ-------------RIGLAVDMDEIEKYQ--EVEEDQDPSCPRLSRELLDEKEPEVLQD 709

Query: 474  SLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPG 533
            SL+ C  T S      D  QP+ +   + EE  +  AL VDR     E ++         
Sbjct: 710  SLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE--------- 760

Query: 534  PTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFL 593
                          GP     +     E+ E + P++ +         ++C+ T  +C  
Sbjct: 761  ------------DQGPPCPRLSR----ELLEVVEPEVLQDSL------DRCYSTPSSCL- 797

Query: 594  ANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLRE 653
                      E  D  +    +    +E+ +   L   E  ++ K       R   + R 
Sbjct: 798  ----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRR 847

Query: 654  KLREGRD--------ASRSLNQHLQALLTPDEPDKSQGQDLQ-EQLAEGCRLAQQLFQKL 704
              +EG +         SR L       +  D  D+S        +L + C+  +  F  L
Sbjct: 848  GRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVL 907

Query: 705  SPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPEDSLEECAITCSNSHG 758
              +      D DE  + +  E+ Q  S PR   E+   +E EV +DSL+ C  T S    
Sbjct: 908  EQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLE 967

Query: 759  PYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR- 817
              D  QP+     + EE  +   L               +   + D EEEE++GP  PR 
Sbjct: 968  LPDLGQPYSSAVYSLEEQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRL 1013

Query: 818  --NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIG---- 871
               L E  E EV Q+S D  YST S   E   S Q Y  +F++LEE+ V  ++D+G    
Sbjct: 1014 SRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEK 1073

Query: 872  --------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSG 916
                    G R  + ++       EDQ    PRLSRELLDEKGPEVLQDSLDRCYSTPSG
Sbjct: 1074 KGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSG 1133

Query: 917  YLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPE 976
             LELTDSCQPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPE
Sbjct: 1134 CLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPE 1193

Query: 977  VLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPP 1036
            VLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPP
Sbjct: 1194 VLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPP 1253

Query: 1037 CPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVG 1096
            CPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALEEKHVGFSLDVG
Sbjct: 1254 CPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVG 1313

Query: 1097 EIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCY 1156
            EIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ + PEVLQDSLDR Y
Sbjct: 1314 EIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSY 1372

Query: 1157 STPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            STPS   EL DS Q YRS FY  E+Q +  A+D+D
Sbjct: 1373 STPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 1407



 Score =  714 bits (1843), Expect = 0.0
 Identities = 488/1093 (44%), Positives = 597/1093 (54%), Gaps = 138/1093 (12%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 3620 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 3679

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 3680 SAVYSLEEQYLGLALDVDRTKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 3736

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 3737 YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 3781

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D   S       L
Sbjct: 3782 KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL 3840

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q             ++    D DE E  Q  E E+  + S PR 
Sbjct: 3841 TDSCQPYRSAFYVLEQQ-------------RVGLAVDMDEIEKYQ--EVEEDQDPSCPRL 3885

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 3886 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKK 3945

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 578
              E ++                       GP     +     E+ E + P++ +      
Sbjct: 3946 DQEEEE---------------------DQGPPCPRLSR----ELLEVVEPEVLQDSL--- 3977

Query: 579  NLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
               ++C+ T  +C            E  D  +    +    +E+ +   L   E  ++ K
Sbjct: 3978 ---DRCYSTPSSCL-----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGK 4023

Query: 639  VLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE---------Q 689
                   R   + R   +EG +        L   L  ++  +     L           +
Sbjct: 4024 GKKRRGRRSKKERRRGRKEGEEDQTPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLE 4083

Query: 690  LAEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPE 743
            L + C+  +  F  L  +      D DE  + +  E+ Q  S PR   E+   +E EV +
Sbjct: 4084 LTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQ 4143

Query: 744  DSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENES 803
            DSL+ C  T S      D  QP+     + EE  +   L               +   + 
Sbjct: 4144 DSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------------VDRTKK 4189

Query: 804  DDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLE 860
            D EEEE++GP  PR    L E  E EV Q+S D  YST S   E   S Q Y  +F++LE
Sbjct: 4190 DQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALE 4249

Query: 861  EQQVCMAVDIG------------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPE 901
            E+ V  ++D+G            G R  + ++       EDQ    PRLSRELLDEKGPE
Sbjct: 4250 EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPE 4309

Query: 902  VLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPS 961
            VLQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPS
Sbjct: 4310 VLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPS 4369

Query: 962  CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 1021
            CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVD
Sbjct: 4370 CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 4429

Query: 1022 RIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSF 1081
            R KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSF
Sbjct: 4430 RTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSF 4489

Query: 1082 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLME 1141
            YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK+RRRGRKEGEEDQNPPCPRL+G+LME
Sbjct: 4490 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKKRRRGRKEGEEDQNPPCPRLNGVLME 4548

Query: 1142 VEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVDNRFLTLMGTS 1201
            VEEPEVLQDSLD CYSTPSMYFELPDSFQHYRSVFYSFEEQHISFAL VDNRF TL  TS
Sbjct: 4549 VEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTS 4608

Query: 1202 LHLVFQMGVIFPQ 1214
            LHLVFQMGVIFPQ
Sbjct: 4609 LHLVFQMGVIFPQ 4621



 Score =  641 bits (1653), Expect = 0.0
 Identities = 456/1070 (42%), Positives = 566/1070 (52%), Gaps = 138/1070 (12%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 1893 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 1952

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 1953 SAVYSLEEQYLGLALDVDRTKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 2009

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 2010 YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 2054

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D S S       L
Sbjct: 2055 KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLEL 2113

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q             ++    D DE E  Q  E E+  + S PR 
Sbjct: 2114 TDSCQPYRSAFYVLEQQ-------------RVGLAVDMDEIEKYQ--EVEEDQDPSCPRL 2158

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 2159 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKK 2218

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 578
              E ++                       GP     +     E+ E + P++ +      
Sbjct: 2219 DQEEEE---------------------DQGPPCPRLSR----ELLEVVEPEVLQDSL--- 2250

Query: 579  NLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
               ++C+ T  +C            E  D  +    +    +E+ +   L   E  ++ K
Sbjct: 2251 ---DRCYSTPSSCL-----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGK 2296

Query: 639  VLVHSQERELTQLREKLREGRD--------ASRSLNQHLQALLTPDEPDKSQGQDLQ-EQ 689
                   R   + R   +EG +         SR L       +  D  D+S        +
Sbjct: 2297 GKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLE 2356

Query: 690  LAEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPE 743
            L + C+  +  F  L  +      D DE  + +  E+ Q  S PR   E+   +E EV +
Sbjct: 2357 LTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQ 2416

Query: 744  DSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENES 803
            DSL+ C  T S      D  QP+     + EE  +   L               +   + 
Sbjct: 2417 DSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------------VDRTKK 2462

Query: 804  DDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLE 860
            D EEEE++GP  PR    L E  E EV Q+S D  YST S   E   S Q Y  +F++LE
Sbjct: 2463 DQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALE 2522

Query: 861  EQQVCMAVDIG------------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPE 901
            E+ V  ++D+G            G R  + ++       EDQ    PRLSRELLDEKGPE
Sbjct: 2523 EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPE 2582

Query: 902  VLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPS 961
            VLQDSLDR YSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPS
Sbjct: 2583 VLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPS 2642

Query: 962  CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 1021
            CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVD
Sbjct: 2643 CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 2702

Query: 1022 RIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSF 1081
            R KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSF
Sbjct: 2703 RTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSF 2762

Query: 1082 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLME 1141
            YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++
Sbjct: 2763 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLD 2821

Query: 1142 VEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
             +EPEVLQDSLDRCYSTPS Y ELPD  Q Y S  YS EEQ++  ALDVD
Sbjct: 2822 EKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 2871



 Score =  634 bits (1634), Expect = 0.0
 Identities = 451/1069 (42%), Positives = 564/1069 (52%), Gaps = 136/1069 (12%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 3376 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 3435

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNV--SMVVSAGPLSSEK 283
            +   + EE  +   L VDR +  D+ ++     P P  +     V    V+         
Sbjct: 3436 SAVYSLEEQYLGLALDVDR-TKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYS 3494

Query: 284  AEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLR 343
               + LE  +  +P        F  L+EK       GF           E E   K   R
Sbjct: 3495 TPSSCLEQPDSCQPY----GSSFYALEEK-----HVGF------SLDVGEIEKKGKGKKR 3539

Query: 344  NERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLT 403
              R+ K+E+   + K+ EE +       S+E    +  E L++  D   S       L  
Sbjct: 3540 RGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTD 3598

Query: 404  PDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAP---R 460
              +P +S    L++             Q++    D DE E  Q  E E+  + S P   R
Sbjct: 3599 SCQPYRSAFYVLEQ-------------QRVGLAVDMDEIEKYQ--EVEEDQDPSCPRLSR 3643

Query: 461  EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHD 520
            E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR     
Sbjct: 3644 ELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQ 3703

Query: 521  ECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNL 580
            E ++                       GP     +     E+ E + P++       ++ 
Sbjct: 3704 EEEE---------------------DQGPPCPRLSR----ELLEVVEPEV------LQDS 3732

Query: 581  KEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVL 640
             ++C+ T  +C            E  D  +    +    +E+ +   L   E  ++ K  
Sbjct: 3733 LDRCYSTPSSCL-----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGK 3781

Query: 641  VHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE----------QL 690
                 R   + R   +EG +        L   L  DE      QD  +          +L
Sbjct: 3782 KRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELL-DEKGPEVLQDSLDRCYSTPSGCLEL 3840

Query: 691  AEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAP---REMQKAEEKEVPED 744
             + C+  +  F  L  +      D DE  + +  E+ Q  S P   RE+   +E EV +D
Sbjct: 3841 TDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQD 3900

Query: 745  SLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD 804
            SL+ C  T S      D  QP+     + EE  +   L               +   + D
Sbjct: 3901 SLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLAL--------------DVDRTKKD 3946

Query: 805  DEEEEEKGPVSP---RNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEE 861
             EEEE++GP  P   R L E  E EV Q+S D  YST S   E   S Q Y  +F++LEE
Sbjct: 3947 QEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEE 4006

Query: 862  QQVCMAVDIG------------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPEV 902
            + V  ++D+G            G R  + ++       EDQ    PRLSRELLDEKGPEV
Sbjct: 4007 KHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQTPPCPRLSRELLDEKGPEV 4066

Query: 903  LQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSC 962
            LQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPSC
Sbjct: 4067 LQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSC 4126

Query: 963  PRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDR 1022
            PRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR
Sbjct: 4127 PRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDR 4186

Query: 1023 IKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFY 1082
             KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFY
Sbjct: 4187 TKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFY 4246

Query: 1083 ALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEV 1142
            ALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ 
Sbjct: 4247 ALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDE 4305

Query: 1143 EEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            + PEVLQDSLDRCYSTPS   EL DS Q YRS FY  E+Q +  A+D+D
Sbjct: 4306 KGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 4354



 Score =  632 bits (1630), Expect = 0.0
 Identities = 449/1070 (41%), Positives = 562/1070 (52%), Gaps = 138/1070 (12%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 673  DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 732

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 733  SAVYSLEEQYLGLALDVDRTKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 789

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 790  YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 834

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D S S       L
Sbjct: 835  KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLEL 893

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q             ++    D DE E  Q  E E+  + S PR 
Sbjct: 894  TDSCQPYRSAFYVLEQQ-------------RVGLAVDMDEIEKYQ--EVEEDQDPSCPRL 938

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 939  SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKK 998

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 578
              E ++                       GP     +     E+ E + P++ +      
Sbjct: 999  DQEEEE---------------------DQGPPCPRLSR----ELLEVVEPEVLQDSL--- 1030

Query: 579  NLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
               ++C+ T  +C            E  D  +    +    +E+ +   L   E  ++ K
Sbjct: 1031 ---DRCYSTPSSCL-----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGK 1076

Query: 639  VLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE---------Q 689
                   R   + R   +EG +        L   L  ++  +     L           +
Sbjct: 1077 GKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLE 1136

Query: 690  LAEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPE 743
            L + C+  +  F  L  +      D DE  + +  E+ Q  S PR   E+   +E EV +
Sbjct: 1137 LTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQ 1196

Query: 744  DSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENES 803
            DSL+ C  T S      D  QP+     + EE  +   L               +   + 
Sbjct: 1197 DSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------------VDRTKK 1242

Query: 804  DDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLE 860
            D EEEE++GP  PR    L E  E EV Q+S D  YST S   E   S Q Y  +F++LE
Sbjct: 1243 DQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALE 1302

Query: 861  EQQVCMAVDIG------------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPE 901
            E+ V  ++D+G            G R  + ++       EDQ    PRLSRELLDEKGPE
Sbjct: 1303 EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPE 1362

Query: 902  VLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPS 961
            VLQDSLDR YSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPS
Sbjct: 1363 VLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPS 1422

Query: 962  CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 1021
            CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVD
Sbjct: 1423 CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 1482

Query: 1022 RIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSF 1081
            R KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSF
Sbjct: 1483 RTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSF 1542

Query: 1082 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLME 1141
            YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++
Sbjct: 1543 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLD 1601

Query: 1142 VEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
             + PEVLQDSLDRCYSTPS   EL DS Q YRS FY  E+Q +  A+D+D
Sbjct: 1602 EKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 1651



 Score =  631 bits (1628), Expect = e-180
 Identities = 451/1070 (42%), Positives = 563/1070 (52%), Gaps = 138/1070 (12%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 917  DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 976

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 977  SAVYSLEEQYLGLALDVDRTKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 1033

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 1034 YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 1078

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D   S       L
Sbjct: 1079 KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL 1137

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q             ++    D DE E  Q  E E+  + S PR 
Sbjct: 1138 TDSCQPYRSAFYVLEQQ-------------RVGLAVDMDEIEKYQ--EVEEDQDPSCPRL 1182

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 1183 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKK 1242

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 578
              E ++                       GP     +     E+ E + P++ +      
Sbjct: 1243 DQEEEE---------------------DQGPPCPRLSR----ELLEVVEPEVLQDSL--- 1274

Query: 579  NLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
               ++C+ T  +C            E  D  +    +    +E+ +   L   E  ++ K
Sbjct: 1275 ---DRCYSTPSSCL-----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGK 1320

Query: 639  VLVHSQERELTQLREKLREGRD--------ASRSLNQHLQALLTPDEPDKSQGQDLQ-EQ 689
                   R   + R   +EG +         SR L       +  D  D+S        +
Sbjct: 1321 GKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLE 1380

Query: 690  LAEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPE 743
            L + C+  +  F  L  +      D DE  + +  E+ Q  S PR   E+   +E EV +
Sbjct: 1381 LTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQ 1440

Query: 744  DSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENES 803
            DSL+ C  T S      D  QP+     + EE  +   L               +   + 
Sbjct: 1441 DSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------------VDRTKK 1486

Query: 804  DDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLE 860
            D EEEE++GP  PR    L E  E EV Q+S D  YST S   E   S Q Y  +F++LE
Sbjct: 1487 DQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALE 1546

Query: 861  EQQVCMAVDIG------------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPE 901
            E+ V  ++D+G            G R  + ++       EDQ    PRLSRELLDEKGPE
Sbjct: 1547 EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPE 1606

Query: 902  VLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPS 961
            VLQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPS
Sbjct: 1607 VLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPS 1666

Query: 962  CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 1021
            CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVD
Sbjct: 1667 CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 1726

Query: 1022 RIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSF 1081
            R KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSF
Sbjct: 1727 RTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSF 1786

Query: 1082 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLME 1141
            YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++
Sbjct: 1787 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLD 1845

Query: 1142 VEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
             + PEVLQDSLDR YSTPS   EL DS Q YRS FY  E+Q +  A+D+D
Sbjct: 1846 EKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 1895



 Score =  628 bits (1620), Expect = e-180
 Identities = 448/1070 (41%), Positives = 561/1070 (52%), Gaps = 138/1070 (12%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 1161 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 1220

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 1221 SAVYSLEEQYLGLALDVDRTKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 1277

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 1278 YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 1322

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D S S       L
Sbjct: 1323 KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLEL 1381

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q             ++    D DE E  Q  E E+  + S PR 
Sbjct: 1382 TDSCQPYRSAFYVLEQQ-------------RVGLAVDMDEIEKYQ--EVEEDQDPSCPRL 1426

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 1427 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKK 1486

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 578
              E ++                       GP     +     E+ E + P++ +      
Sbjct: 1487 DQEEEE---------------------DQGPPCPRLSR----ELLEVVEPEVLQDSL--- 1518

Query: 579  NLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
               ++C+ T  +C            E  D  +    +    +E+ +   L   E  ++ K
Sbjct: 1519 ---DRCYSTPSSCL-----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGK 1564

Query: 639  VLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE---------Q 689
                   R   + R   +EG +        L   L  ++  +     L           +
Sbjct: 1565 GKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLE 1624

Query: 690  LAEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPE 743
            L + C+  +  F  L  +      D DE  + +  E+ Q  S PR   E+   +E EV +
Sbjct: 1625 LTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQ 1684

Query: 744  DSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENES 803
            DSL+ C  T S      D  QP+     + EE  +   L               +   + 
Sbjct: 1685 DSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------------VDRTKK 1730

Query: 804  DDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLE 860
            D EEEE++GP  PR    L E  E EV Q+S D  YST S   E   S Q Y  +F++LE
Sbjct: 1731 DQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALE 1790

Query: 861  EQQVCMAVDIG------------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPE 901
            E+ V  ++D+G            G R  + ++       EDQ    PRLSRELLDEKGPE
Sbjct: 1791 EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPE 1850

Query: 902  VLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPS 961
            VLQDSLDR YSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPS
Sbjct: 1851 VLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPS 1910

Query: 962  CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 1021
            CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVD
Sbjct: 1911 CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 1970

Query: 1022 RIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSF 1081
            R KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSF
Sbjct: 1971 RTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSF 2030

Query: 1082 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLME 1141
            YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++
Sbjct: 2031 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLD 2089

Query: 1142 VEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
             + PEVLQDSLDR YSTPS   EL DS Q YRS FY  E+Q +  A+D+D
Sbjct: 2090 EKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 2139



 Score =  627 bits (1618), Expect = e-179
 Identities = 450/1070 (42%), Positives = 562/1070 (52%), Gaps = 138/1070 (12%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 1405 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 1464

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 1465 SAVYSLEEQYLGLALDVDRTKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 1521

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 1522 YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 1566

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D   S       L
Sbjct: 1567 KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL 1625

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q             ++    D DE E  Q  E E+  + S PR 
Sbjct: 1626 TDSCQPYRSAFYVLEQQ-------------RVGLAVDMDEIEKYQ--EVEEDQDPSCPRL 1670

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 1671 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKK 1730

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 578
              E ++                       GP     +     E+ E + P++ +      
Sbjct: 1731 DQEEEE---------------------DQGPPCPRLSR----ELLEVVEPEVLQDSL--- 1762

Query: 579  NLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
               ++C+ T  +C            E  D  +    +    +E+ +   L   E  ++ K
Sbjct: 1763 ---DRCYSTPSSCL-----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGK 1808

Query: 639  VLVHSQERELTQLREKLREGRD--------ASRSLNQHLQALLTPDEPDKSQGQDLQ-EQ 689
                   R   + R   +EG +         SR L       +  D  D+S        +
Sbjct: 1809 GKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLE 1868

Query: 690  LAEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPE 743
            L + C+  +  F  L  +      D DE  + +  E+ Q  S PR   E+   +E EV +
Sbjct: 1869 LTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQ 1928

Query: 744  DSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENES 803
            DSL+ C  T S      D  QP+     + EE  +   L               +   + 
Sbjct: 1929 DSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------------VDRTKK 1974

Query: 804  DDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLE 860
            D EEEE++GP  PR    L E  E EV Q+S D  YST S   E   S Q Y  +F++LE
Sbjct: 1975 DQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALE 2034

Query: 861  EQQVCMAVDIG------------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPE 901
            E+ V  ++D+G            G R  + ++       EDQ    PRLSRELLDEKGPE
Sbjct: 2035 EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPE 2094

Query: 902  VLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPS 961
            VLQDSLDR YSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPS
Sbjct: 2095 VLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPS 2154

Query: 962  CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 1021
            CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVD
Sbjct: 2155 CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 2214

Query: 1022 RIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSF 1081
            R KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSF
Sbjct: 2215 RTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSF 2274

Query: 1082 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLME 1141
            YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++
Sbjct: 2275 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLD 2333

Query: 1142 VEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
             + PEVLQDSLDR YSTPS   EL DS Q YRS FY  E+Q +  A+D+D
Sbjct: 2334 EKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 2383



 Score =  625 bits (1613), Expect = e-179
 Identities = 441/1047 (42%), Positives = 550/1047 (52%), Gaps = 135/1047 (12%)

Query: 189  REVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSH 248
            RE+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +   L VDR    
Sbjct: 3155 RELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKD 3214

Query: 249  DECQDAVNILPVPGPTSSATNVSMVVSAGPLSS----EKAEMNILEMNEKLRPQLAEKKQ 304
             E ++       P P  S   + +V       S         + LE  +  +P       
Sbjct: 3215 QEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY----GS 3267

Query: 305  QFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELR 364
             F  L+EK       GF  +        E E   K   R  R+ K+E+   + K+ EE +
Sbjct: 3268 SFYALEEKH-----VGFSLD------VGEIEKKGKGKKRRGRRSKKERRRGR-KEGEEDQ 3315

Query: 365  QYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCR 424
                   S+E    +  E L++  D   S       L    +P +S    L++Q      
Sbjct: 3316 NPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ------ 3369

Query: 425  LAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAIT 481
                   ++    D DE E  Q  E E+  + S PR   E+   +E +V +DSL+ C  T
Sbjct: 3370 -------RVGLAVDMDEIEKYQ--EVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYST 3420

Query: 482  CSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNV 541
             S      D  QP+ +   + EE  +  AL VDR     E ++                 
Sbjct: 3421 PSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE----------------- 3463

Query: 542  SMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYK 601
                  GP     +     E+ E + P++ +         ++C+ T  +C          
Sbjct: 3464 ----DQGPPCPRLSR----ELLEVVEPEVLQDSL------DRCYSTPSSCL--------- 3500

Query: 602  YEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 661
              E  D  +    +    +E+ +   L   E  ++ K       R   + R   +EG + 
Sbjct: 3501 --EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEED 3558

Query: 662  SRSLNQHLQALLTPDEPDKSQGQDLQE---------QLAEGCRLAQQLFQKLSPENDN-- 710
                   L   L  ++  +     L           +L + C+  +  F  L  +     
Sbjct: 3559 QNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLA 3618

Query: 711  -DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPH 766
             D DE  + +  E+ Q  S PR   E+   +E EV +DSL+ C  T S      D  QP+
Sbjct: 3619 VDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY 3678

Query: 767  RKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESE 823
                 + EE  +   L               +   + D EEEE++GP  PR    L E  
Sbjct: 3679 SSAVYSLEEQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRLSRELLEVV 3724

Query: 824  EEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIG------------ 871
            E EV Q+S D  YST S   E   S Q Y  +F++LEE+ V  ++D+G            
Sbjct: 3725 EPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRR 3784

Query: 872  GHRWDQVKK-------EDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSC 924
            G R  + ++       EDQ    PRLSRELLDEKGPEVLQDSLDRCYSTPSG LELTDSC
Sbjct: 3785 GRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSC 3844

Query: 925  QPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDR 984
            QPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDR
Sbjct: 3845 QPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDR 3904

Query: 985  CYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSREL 1044
            CYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSREL
Sbjct: 3905 CYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSREL 3964

Query: 1045 LEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKG 1104
            LE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKG
Sbjct: 3965 LEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKG 4024

Query: 1105 KKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFE 1164
            KKRRGRRS KK RRRGRKEGEEDQ PPCPRLS  L++ + PEVLQDSLDRCYSTPS   E
Sbjct: 4025 KKRRGRRS-KKERRRGRKEGEEDQTPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLE 4083

Query: 1165 LPDSFQHYRSVFYSFEEQHISFALDVD 1191
            L DS Q YRS FY  E+Q +  A+D+D
Sbjct: 4084 LTDSCQPYRSAFYVLEQQRVGLAVDMD 4110



 Score =  587 bits (1514), Expect = e-167
 Identities = 446/1116 (39%), Positives = 571/1116 (51%), Gaps = 136/1116 (12%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 2137 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 2196

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 2197 SAVYSLEEQYLGLALDVDRTKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 2253

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 2254 YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 2298

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D S S       L
Sbjct: 2299 KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLEL 2357

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q             ++    D DE E  Q  E E+  + S PR 
Sbjct: 2358 TDSCQPYRSAFYVLEQQ-------------RVGLAVDMDEIEKYQ--EVEEDQDPSCPRL 2402

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 2403 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKK 2462

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS----EKAEMNILEMNEKLRPQLAEKK 574
              E ++       P P  S   + +V       S         + LE  +  +P      
Sbjct: 2463 DQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY----G 2515

Query: 575  QQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEEL 634
              F  L+EK     L      ++ K K    +   K   R  ++ +E++     + + EL
Sbjct: 2516 SSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSREL 2575

Query: 635  RQYK---VLVHSQERELT------QLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQD 685
               K   VL  S +R  +      +L +  +  R A   L Q    L   D  +  + Q+
Sbjct: 2576 LDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAV-DMDEIEKYQE 2634

Query: 686  LQEQLAEGC-RLAQQLFQKLSPENDNDH-------------------------------- 712
            ++E     C RL+++L  +  PE   D                                 
Sbjct: 2635 VEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQY 2694

Query: 713  -----DEDVQVEVAEKVQKSSAP-----REMQKAEEKEVPEDSLEECAITCSNSHGPYDS 762
                 D D   +  E+ +    P     RE+ +  E EV +DSL+ C  T S+     DS
Sbjct: 2695 LGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDS 2754

Query: 763  NQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPR 817
             QP+  +    EE  V  +L       + +        ++ +      E EE++ P  PR
Sbjct: 2755 CQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPR 2814

Query: 818  ---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHR 874
                L + +E EV Q+S D  YST S   E+    Q YS   +SLEEQ + +A+D+   +
Sbjct: 2815 LSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTK 2874

Query: 875  WDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYIL 934
             DQ ++EDQ    PRLSRELL+   PEVLQDSLDRCYSTPS  LE  DSCQPY S+FY L
Sbjct: 2875 KDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYAL 2934

Query: 935  EQQRVGWALDMDEIEKY-------------------QEVEEDQDPSCPRLSRELLDEKEP 975
            E++ VG++LD+ EIEK                    +E EEDQ+P CPRLSRELLDEKEP
Sbjct: 2935 EEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEP 2994

Query: 976  EVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGP 1035
            EVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGP
Sbjct: 2995 EVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGP 3054

Query: 1036 PCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDV 1095
            PCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALEEKHVGFSLDV
Sbjct: 3055 PCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDV 3114

Query: 1096 GEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRC 1155
            GEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ +EPEVLQDSLDRC
Sbjct: 3115 GEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRC 3173

Query: 1156 YSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            YSTPS Y ELPD  Q Y S  YS EEQ++  ALDVD
Sbjct: 3174 YSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 3209



 Score =  580 bits (1494), Expect = e-165
 Identities = 436/1067 (40%), Positives = 553/1067 (51%), Gaps = 113/1067 (10%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 2381 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 2440

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 2441 SAVYSLEEQYLGLALDVDRTKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 2497

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 2498 YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 2542

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D S S       L
Sbjct: 2543 KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLEL 2601

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q             ++    D DE E  Q  E E+  + S PR 
Sbjct: 2602 TDSCQPYRSAFYVLEQQ-------------RVGLAVDMDEIEKYQ--EVEEDQDPSCPRL 2646

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 2647 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKK 2706

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS----EKAEMNILEMNEKLRPQLAEKK 574
              E ++       P P  S   + +V       S         + LE  +  +P      
Sbjct: 2707 DQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY----G 2759

Query: 575  QQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEEL 634
              F  L+EK     L      ++ K K    +   K   R  ++ +E++     + + EL
Sbjct: 2760 SSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSREL 2819

Query: 635  RQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGC 694
               K              E L++  D   S       L    +P  S    L+EQ   G 
Sbjct: 2820 LDEKE------------PEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL-GL 2866

Query: 695  RLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPEDSLEECAI 751
             L     +K     D + +ED         Q    PR   E+ +  E EV +DSL+ C  
Sbjct: 2867 ALDVDRTKK-----DQEEEED---------QGPPCPRLSRELLEVVEPEVLQDSLDRCYS 2912

Query: 752  TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DE 806
            T S+     DS QP+  +    EE  V  +L       + +        ++ +      E
Sbjct: 2913 TPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKE 2972

Query: 807  EEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQ 863
             EE++ P  PR    L + +E EV Q+S D  YST S   E+    Q YS   +SLEEQ 
Sbjct: 2973 GEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQY 3032

Query: 864  VCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDS 923
            + +A+D+   + DQ ++EDQ    PRLSRELL+   PEVLQDSLDRCYSTPS  LE  DS
Sbjct: 3033 LGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDS 3092

Query: 924  CQPYRSAFYILEQQRVGWALDMDEIEKY-------------------QEVEEDQDPSCPR 964
            CQPY S+FY LE++ VG++LD+ EIEK                    +E EEDQ+P CPR
Sbjct: 3093 CQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPR 3152

Query: 965  LSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIK 1024
            LSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR K
Sbjct: 3153 LSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTK 3212

Query: 1025 KDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYAL 1084
            KDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFYAL
Sbjct: 3213 KDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYAL 3272

Query: 1085 EEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEE 1144
            EEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ + 
Sbjct: 3273 EEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDEKG 3331

Query: 1145 PEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            PEVLQDSLDRCYSTPS   EL DS Q YRS FY  E+Q +  A+D+D
Sbjct: 3332 PEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 3378



 Score =  432 bits (1111), Expect = e-121
 Identities = 372/1161 (32%), Positives = 532/1161 (45%), Gaps = 168/1161 (14%)

Query: 90   EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPD---------EPDKSQ 140
            +E+ +Y+ +   Q+    +L  +L + ++     +   +   TP          +P  S 
Sbjct: 3378 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 3437

Query: 141  GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVP 200
               L+EQ   G  L    V +   + +E+ED+                RE+ +  E +V 
Sbjct: 3438 VYSLEEQYL-GLALD---VDRTKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVL 3485

Query: 201  EDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVV-------------DRESS 247
            +DSL+ C  T S+     DS QP+ +     EE  V  +L V              R S 
Sbjct: 3486 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSK 3545

Query: 248  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSE-------KAEMNILEMNEKLRPQLA 300
             +  +          P     +  ++   GP   +             LE+ +  +P   
Sbjct: 3546 KERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPY-- 3603

Query: 301  EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEEC-EDLIKSMLRNERQFKEEKLAEQLKQ 359
              +  F  L++     Q  G   +     KY+E  ED   S  R  R+  +EK  E L+ 
Sbjct: 3604 --RSAFYVLEQ-----QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQD 3656

Query: 360  AEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQL 419
            + + R Y     S   EL  L                         +P  S    L+EQ 
Sbjct: 3657 SLD-RCYS--TPSGYLELPDL------------------------GQPYSSAVYSLEEQY 3689

Query: 420  AEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECA 479
              G  L    V +   + +E+ED+                RE+ +  E +V +DSL+ C 
Sbjct: 3690 L-GLALD---VDRTKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVLQDSLDRCY 3737

Query: 480  ITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSAT 539
             T S+     DS QP+ +     EE  V  +L V       +           G      
Sbjct: 3738 STPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGK-----------GKKRRGR 3786

Query: 540  NVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKK--QQFRNLKEKCFVTQLACFLANQQ 597
                    G    E+ +        +L  +L ++K  +  ++  ++C+ T   C      
Sbjct: 3787 RSKKERRRGRKEGEEDQN---PPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELT-- 3841

Query: 598  NKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLRE 657
                 + C+       R+     E++        +E+ +Y+ +   Q+    +L  +L +
Sbjct: 3842 -----DSCQP-----YRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLD 3891

Query: 658  GRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQ 717
             ++     +   +   TP      +  DL +  +      ++ +  L+ + D    +D +
Sbjct: 3892 EKEPEVLQDSLDRCYSTPS--GYLELPDLGQPYSSAVYSLEEQYLGLALDVDRT-KKDQE 3948

Query: 718  VEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDK 777
             E  +        RE+ +  E EV +DSL+ C  T S+     DS QP+  +    EE  
Sbjct: 3949 EEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKH 4008

Query: 778  VDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPRNLQESEEE---EVPQ 829
            V  +L       + +        ++ +      E EE++ P  PR  +E  +E   EV Q
Sbjct: 4009 VGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQTPPCPRLSRELLDEKGPEVLQ 4068

Query: 830  ESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPR 889
            +S D  YST S   E+  S Q Y   F+ LE+Q+V +AVD+      Q  +EDQ+ + PR
Sbjct: 4069 DSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPR 4128

Query: 890  LSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIE 949
            LSRELLDEK PEVLQDSLDRCYSTPSGYLEL D  QPY SA Y LE+Q +G ALD+D  +
Sbjct: 4129 LSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTK 4188

Query: 950  KYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSL 1009
            K QE EEDQ P CPRLSRELL+  EPEVLQDSLDRCYSTPS  LE PD  QPY S+ Y+L
Sbjct: 4189 KDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYAL 4248

Query: 1010 EEQYLGLALDVDRIKKD-------------------QEEEEDQGPPCPRLSRELLEAVEP 1050
            EE+++G +LDV  I+K                    +E EEDQ PPCPRLSRELL+   P
Sbjct: 4249 EEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGP 4308

Query: 1051 EVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGR 1110
            EVLQDSLDRCYSTPS CLE  DSC PY S+FY LE++ VG ++D+ EIEK          
Sbjct: 4309 EVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK---------- 4358

Query: 1111 RSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQ 1170
                       +E EEDQ+P CPRLS  L++ +EPEVLQDSLDRCYSTPS Y ELPD  Q
Sbjct: 4359 ----------YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQ 4408

Query: 1171 HYRSVFYSFEEQHISFALDVD 1191
             Y S  YS EEQ++  ALDVD
Sbjct: 4409 PYSSAVYSLEEQYLGLALDVD 4429



 Score =  425 bits (1092), Expect = e-118
 Identities = 378/1180 (32%), Positives = 528/1180 (44%), Gaps = 206/1180 (17%)

Query: 90   EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPD---------EPDKSQ 140
            +E+ +Y+ +   Q+    +L  +L + ++     +   +   TP          +P  S 
Sbjct: 1407 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 1466

Query: 141  GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVP 200
               L+EQ   G  L    V +   + +E+ED+                RE+ +  E +V 
Sbjct: 1467 VYSLEEQYL-GLALD---VDRTKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVL 1514

Query: 201  EDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVV-------------DRESS 247
            +DSL+ C  T S+     DS QP+ +     EE  V  +L V              R S 
Sbjct: 1515 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSK 1574

Query: 248  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSE-------KAEMNILEMNEKLRPQLA 300
             +  +          P     +  ++   GP   +             LE+ +  +P   
Sbjct: 1575 KERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPY-- 1632

Query: 301  EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEEC-EDLIKSMLRNERQFKEEKLAEQLKQ 359
              +  F  L++     Q  G   +     KY+E  ED   S  R  R+  +EK  E L+ 
Sbjct: 1633 --RSAFYVLEQ-----QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQD 1685

Query: 360  AEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQL 419
            + + R Y     S   EL  L                         +P  S    L+EQ 
Sbjct: 1686 SLD-RCYS--TPSGYLELPDL------------------------GQPYSSAVYSLEEQY 1718

Query: 420  AEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECA 479
              G  L    V +   + +E+ED+                RE+ +  E +V +DSL+ C 
Sbjct: 1719 L-GLALD---VDRTKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVLQDSLDRCY 1766

Query: 480  ITCSNSHGPCDSNQPHKNINITFEEDKVNSALVV-------------DRESSHDECQDAV 526
             T S+     DS QP+ +     EE  V  +L V              R S  +  +   
Sbjct: 1767 STPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRK 1826

Query: 527  NILPVPGPTSSATNVSMVVSAGPL-------SSEKAEMNILEMNEKLRPQLAEKKQQFRN 579
                   P     +  ++   GP         S       LE+ +  +P     +  F  
Sbjct: 1827 EGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPY----RSAFYV 1882

Query: 580  LKEKCFVTQLACFLANQQNKYKYEEC-KDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
            L++     Q      +     KY+E  +D   S  R  R+  +EK  E L+ + +     
Sbjct: 1883 LEQ-----QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLD----- 1932

Query: 639  VLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQ 698
               +S      +L +  +    A  SL +    L    +  K   ++ ++Q     RL++
Sbjct: 1933 -RCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSR 1991

Query: 699  QLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHG 758
            +L + + P                                 EV +DSL+ C  T S+   
Sbjct: 1992 ELLEVVEP---------------------------------EVLQDSLDRCYSTPSSCLE 2018

Query: 759  PYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGP 813
              DS QP+  +    EE  V  +L       + +        ++ +      E EE++ P
Sbjct: 2019 QPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNP 2078

Query: 814  VSPRNLQESEEE---EVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDI 870
              PR  +E  +E   EV Q+S D  YST S   E+  S Q Y   F+ LE+Q+V +AVD+
Sbjct: 2079 PCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDM 2138

Query: 871  GGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSA 930
                  Q  +EDQ+ + PRLSRELLDEK PEVLQDSLDRCYSTPSGYLEL D  QPY SA
Sbjct: 2139 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 2198

Query: 931  FYILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPS 990
             Y LE+Q +G ALD+D  +K QE EEDQ P CPRLSRELL+  EPEVLQDSLDRCYSTPS
Sbjct: 2199 VYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPS 2258

Query: 991  GYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEEEE 1031
              LE PD  QPY S+ Y+LEE+++G +LDV  I+K                    +E EE
Sbjct: 2259 SCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 2318

Query: 1032 DQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGF 1091
            DQ PPCPRLSRELL+   PEVLQDSLDR YSTPS CLE  DSC PY S+FY LE++ VG 
Sbjct: 2319 DQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGL 2378

Query: 1092 SLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDS 1151
            ++D+ EIEK                     +E EEDQ+P CPRLS  L++ +EPEVLQDS
Sbjct: 2379 AVDMDEIEK--------------------YQEVEEDQDPSCPRLSRELLDEKEPEVLQDS 2418

Query: 1152 LDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            LDRCYSTPS Y ELPD  Q Y S  YS EEQ++  ALDVD
Sbjct: 2419 LDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 2458



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 98/454 (21%), Positives = 161/454 (35%), Gaps = 90/454 (19%)

Query: 90   EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPD---------EPDKSQ 140
            +E+ +Y+ +   Q+    +L  +L + ++     +   +   TP          +P  S 
Sbjct: 2383 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 2442

Query: 141  GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVP 200
               L+EQ   G  L    V +   + +E+ED+                RE+ +  E +V 
Sbjct: 2443 VYSLEEQYL-GLALD---VDRTKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVL 2490

Query: 201  EDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVV-------------DRESS 247
            +DSL+ C  T S+     DS QP+ +     EE  V  +L V              R S 
Sbjct: 2491 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSK 2550

Query: 248  HDECQDAVNILPVPGPTSSATNVSMVVSAGPL-------SSEKAEMNILEMNEKLRPQLA 300
             +  +          P     +  ++   GP         S       LE+ +  +P   
Sbjct: 2551 KERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPY-- 2608

Query: 301  EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEEC-EDLIKSMLRNERQFKEEKLAEQLKQ 359
              +  F  L++     Q  G   +     KY+E  ED   S  R  R+  +EK  E L+ 
Sbjct: 2609 --RSAFYVLEQ-----QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQD 2661

Query: 360  AEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQL 419
            + + R Y     S   EL  L                         +P  S    L+EQ 
Sbjct: 2662 SLD-RCYS--TPSGYLELPDL------------------------GQPYSSAVYSLEEQY 2694

Query: 420  AEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECA 479
              G  L    V +   + +E+ED+                RE+ +  E +V +DSL+ C 
Sbjct: 2695 L-GLALD---VDRTKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVLQDSLDRCY 2742

Query: 480  ITCSNSHGPCDSNQPHKNINITFEEDKVNSALVV 513
             T S+     DS QP+ +     EE  V  +L V
Sbjct: 2743 STPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDV 2776



 Score = 32.0 bits (71), Expect = 3.7
 Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 3/80 (3%)

Query: 177  EEAEKVLESSAPREVQKAEESKVPE---DSLEECAITCSNSHGPCDSNQPHKNINITFEE 233
            +E E+      PR  ++  + K PE   DSL+ C  T S      DS QP+++     E+
Sbjct: 3309 KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQ 3368

Query: 234  DKVNSTLVVDRESSHDECQD 253
             +V   + +D    + E ++
Sbjct: 3369 QRVGLAVDMDEIEKYQEVEE 3388



 Score = 31.6 bits (70), Expect = 4.8
 Identities = 37/162 (22%), Positives = 66/162 (40%), Gaps = 21/162 (12%)

Query: 90   EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPD---------EPDKSQ 140
            +E+ +Y+ +   Q+    +L  +L + ++     +   +   TP          +P  S 
Sbjct: 4354 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 4413

Query: 141  GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVP 200
               L+EQ   G  L    V +   + +E+ED+                RE+ +  E +V 
Sbjct: 4414 VYSLEEQYL-GLALD---VDRTKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVL 4461

Query: 201  EDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVV 242
            +DSL+ C  T S+     DS QP+ +     EE  V  +L V
Sbjct: 4462 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDV 4503


>gi|119709825 neuroblastoma breakpoint family, member 11-like [Homo
            sapiens]
          Length = 790

 Score = 1342 bits (3472), Expect = 0.0
 Identities = 685/768 (89%), Positives = 703/768 (91%), Gaps = 17/768 (2%)

Query: 361  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420
            EE++QYKVLVHSQERELTQLREKLREGRDASRSLN+HLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 15   EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74

Query: 421  EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAI 480
            EGCRLAQHLVQKLSPENDEDEDEDVQVEE EKVLESSAPREVQKAEESKVPEDSLEECAI
Sbjct: 75   EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134

Query: 481  TCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATN 540
            TCSNSHGPCDS QPHKNI ITFEEDKVNS+LVVDRESSHD CQDA+NILPVPGPTSSATN
Sbjct: 135  TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATN 194

Query: 541  VSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKY 600
            VSMVVSAGPLSSEKAEMNILE+NEKL PQLAEKKQQFR+LKEKCFVTQ+ACFLA QQNKY
Sbjct: 195  VSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKY 254

Query: 601  KYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 660
            KYEECKDLIKS+LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD
Sbjct: 255  KYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 314

Query: 661  ASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEV 720
            ASRSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQ L QKLSPENDND DEDVQVEV
Sbjct: 315  ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEV 374

Query: 721  AEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 780
            AEKVQKSS+PREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS
Sbjct: 375  AEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 434

Query: 781  TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 840
            TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS
Sbjct: 435  TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 494

Query: 841  IPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGP 900
            IPPE LASYQSYS TFHSLEEQQVCMAVDIG HRWDQVKKEDQEATGPRLSRELLDEK P
Sbjct: 495  IPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEP 554

Query: 901  EVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDP 960
            EVLQDSLDRCYSTPS YL LTDSCQPYRSAFY+LEQQR+G A+DMDEIEKYQEVEEDQDP
Sbjct: 555  EVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDP 614

Query: 961  SCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV 1020
            SCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV
Sbjct: 615  SCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV 674

Query: 1021 DRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSS 1080
            DRIKKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLD     P   L       P    
Sbjct: 675  DRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLP-VVLNSLTPASPTEVP 733

Query: 1081 FYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQ 1128
            F    +  + F L   ++                KRR RGRKEGEEDQ
Sbjct: 734  FMHWRKNMLAFLLTWEKL----------------KRRGRGRKEGEEDQ 765



 Score =  810 bits (2092), Expect = 0.0
 Identities = 470/750 (62%), Positives = 538/750 (71%), Gaps = 58/750 (7%)

Query: 90  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 149
           EE++QYKVLVHSQERELTQLREKLREGRDASRSLN+HLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 15  EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74

Query: 150 EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAI 209
           EGCRLAQHLVQKLSPENDEDEDEDVQVEE EKVLESSAPREVQKAEESKVPEDSLEECAI
Sbjct: 75  EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134

Query: 210 TCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATN 269
           TCSNSHGPCDS QPHKNI ITFEEDKVNS+LVVDRESSHD CQDA+NILPVPGPTSSATN
Sbjct: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATN 194

Query: 270 VSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKY 329
           VSMVVSAGPLSSEKAEMNILE+NEKL PQLAEKKQQFR+LKEKCFVTQ+A FLA QQNKY
Sbjct: 195 VSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKY 254

Query: 330 KYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 389
           KYEEC+DLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD
Sbjct: 255 KYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 314

Query: 390 ASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEE 449
           ASRSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE 
Sbjct: 315 ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEV 374

Query: 450 AEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNS 509
           AEKV +SS+PRE+QKAEE +VPEDSLEECAITCSNSHGP DSNQPH+   ITFEEDKV+S
Sbjct: 375 AEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 434

Query: 510 ALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQ 569
            L+    SSH E +DAV+I+P      + ++       GP+S      N+ E  E+  PQ
Sbjct: 435 TLI--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQ 483

Query: 570 LAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLK 629
                + +  L       +LA + +     +  EE + +  +V     ++ + K  +Q  
Sbjct: 484 -ESWDEGYSTLSIP--PERLASYQSYSSTFHSLEE-QQVCMAVDIGRHRWDQVKKEDQ-- 537

Query: 630 QAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQ 689
           +A   R  + L+  +E E+      L++  D   S       L    +P +S    L++Q
Sbjct: 538 EATGPRLSRELLDEKEPEV------LQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQ 591

Query: 690 LAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAP---REMQKAEEKEVPEDSL 746
                R+   +          D DE  + +  E+ Q  S P   RE+   +E EV +DSL
Sbjct: 592 -----RIGLAV----------DMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSL 636

Query: 747 EECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDE 806
           + C  T S      D  QP+R    + EE  +   L               +   + D E
Sbjct: 637 DRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLAL--------------DVDRIKKDQE 682

Query: 807 EEEEKGPVSP---RNLQESEEEEVPQESWD 833
           EEE++GP  P   R L E  E EV Q+S D
Sbjct: 683 EEEDQGPPCPRLSRELLEVVEPEVLQDSLD 712



 Score =  449 bits (1155), Expect = e-126
 Identities = 279/524 (53%), Positives = 340/524 (64%), Gaps = 41/524 (7%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
           MVVSAGP SSEKAE NILEINEKL PQLAE KQQFR+LKEKCFVTQ+A FLA +Q KYKY
Sbjct: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKY 256

Query: 61  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
           EECKDLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 257 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 316

Query: 121 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
           RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE AE
Sbjct: 317 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 376

Query: 181 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
           KV +SS+PRE+QKAEE +VPEDSLEECAITCSNSHGP DSNQPH+   ITFEEDKV+STL
Sbjct: 377 KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 436

Query: 241 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 300
           +    SSH E +DAV+I+P      + ++       GP+S      N+ E  E+  PQ  
Sbjct: 437 I--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQ-E 484

Query: 301 EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA 360
              + +  L       +LA + +     +  EE +  +   +   R    +++ ++ ++A
Sbjct: 485 SWDEGYSTLSIP--PERLASYQSYSSTFHSLEEQQVCMAVDIGRHRW---DQVKKEDQEA 539

Query: 361 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420
              R  + L+  +E E+      L++  D   S       L    +P +S    L++   
Sbjct: 540 TGPRLSRELLDEKEPEV------LQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQ--- 590

Query: 421 EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAP---REVQKAEESKVPEDSLEE 477
                     Q++    D DE E  Q  E E+  + S P   RE+   +E +V +DSL+ 
Sbjct: 591 ----------QRIGLAVDMDEIEKYQ--EVEEDQDPSCPRLSRELLAEKEPEVLQDSLDR 638

Query: 478 CAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDE 521
           C  T S      D  QP+++   + EE  +  AL VDR     E
Sbjct: 639 CYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQE 682



 Score =  231 bits (589), Expect = 3e-60
 Identities = 143/326 (43%), Positives = 188/326 (57%), Gaps = 34/326 (10%)

Query: 877  QVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQ 936
            +V ++ Q+++ PR   E+   +  EV +DSL+ C  T S      DS QP+R      E+
Sbjct: 373  EVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEE 429

Query: 937  QRVG-----------WALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRC 985
             +V            W   +  I + +  +E+++   P   R L + +E EV Q+S D  
Sbjct: 430  DKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEG 489

Query: 986  YSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL 1045
            YST S   E     Q Y S  +SLEEQ + +A+D+ R + DQ ++EDQ    PRLSRELL
Sbjct: 490  YSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELL 549

Query: 1046 EAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGK 1105
            +  EPEVLQDSLDRCYSTPS  L   DSC PY S+FY LE++ +G ++D+ EIEK     
Sbjct: 550  DEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY---- 605

Query: 1106 KRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFEL 1165
                            +E EEDQ+P CPRLS  L+  +EPEVLQDSLDRCYSTPS Y EL
Sbjct: 606  ----------------QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLEL 649

Query: 1166 PDSFQHYRSVFYSFEEQHISFALDVD 1191
            PD  Q YRS  YS EEQ++  ALDVD
Sbjct: 650  PDLGQPYRSAVYSLEEQYLGLALDVD 675



 Score = 34.3 bits (77), Expect = 0.74
 Identities = 21/67 (31%), Positives = 35/67 (52%)

Query: 1125 EEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHI 1184
            EED+          + + EE +V +DSL+ C  T S      DS Q ++++  +FEE  +
Sbjct: 102  EEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161

Query: 1185 SFALDVD 1191
            + +L VD
Sbjct: 162  NSSLVVD 168


>gi|156071420 hypothetical protein LOC728912 [Homo sapiens]
          Length = 790

 Score = 1340 bits (3469), Expect = 0.0
 Identities = 684/768 (89%), Positives = 703/768 (91%), Gaps = 17/768 (2%)

Query: 361  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420
            +E++QYKVLVHSQERELTQLREKLREGRDASRSLN+HLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 15   QEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74

Query: 421  EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAI 480
            EGCRLAQHLVQKLSPENDEDEDEDVQVEE EKVLESSAPREVQKAEESKVPEDSLEECAI
Sbjct: 75   EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134

Query: 481  TCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATN 540
            TCSNSHGPCDS QPHKNI ITFEEDKVNS+LVVDRESSHD CQDA+NILPVPGPTSSATN
Sbjct: 135  TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATN 194

Query: 541  VSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKY 600
            VSMVVSAGPLSSEKAEMNILE+NEKL PQLAEKKQQFR+LKEKCFVTQ+ACFLA QQNKY
Sbjct: 195  VSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKY 254

Query: 601  KYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 660
            KYEECKDLIKS+LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD
Sbjct: 255  KYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 314

Query: 661  ASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEV 720
            ASRSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQ L QKLSPENDND DEDVQVEV
Sbjct: 315  ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEV 374

Query: 721  AEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 780
            AEKVQKSS+PREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS
Sbjct: 375  AEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 434

Query: 781  TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 840
            TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS
Sbjct: 435  TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 494

Query: 841  IPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGP 900
            IPPE LASYQSYS TFHSLEEQQVCMAVDIG HRWDQVKKEDQEATGPRLSRELLDEK P
Sbjct: 495  IPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEP 554

Query: 901  EVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDP 960
            EVLQDSLDRCYSTPS YL LTDSCQPYRSAFY+LEQQR+G A+DMDEIEKYQEVEEDQDP
Sbjct: 555  EVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDP 614

Query: 961  SCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV 1020
            SCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV
Sbjct: 615  SCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV 674

Query: 1021 DRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSS 1080
            DRIKKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLD     P   L       P    
Sbjct: 675  DRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLP-VVLNSLTPASPTEVP 733

Query: 1081 FYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQ 1128
            F    +  + F L   ++                KRR RGRKEGEEDQ
Sbjct: 734  FMHWRKNMLAFLLTWEKL----------------KRRGRGRKEGEEDQ 765



 Score =  809 bits (2089), Expect = 0.0
 Identities = 469/750 (62%), Positives = 538/750 (71%), Gaps = 58/750 (7%)

Query: 90  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 149
           +E++QYKVLVHSQERELTQLREKLREGRDASRSLN+HLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 15  QEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74

Query: 150 EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAI 209
           EGCRLAQHLVQKLSPENDEDEDEDVQVEE EKVLESSAPREVQKAEESKVPEDSLEECAI
Sbjct: 75  EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134

Query: 210 TCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATN 269
           TCSNSHGPCDS QPHKNI ITFEEDKVNS+LVVDRESSHD CQDA+NILPVPGPTSSATN
Sbjct: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATN 194

Query: 270 VSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKY 329
           VSMVVSAGPLSSEKAEMNILE+NEKL PQLAEKKQQFR+LKEKCFVTQ+A FLA QQNKY
Sbjct: 195 VSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKY 254

Query: 330 KYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 389
           KYEEC+DLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD
Sbjct: 255 KYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 314

Query: 390 ASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEE 449
           ASRSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE 
Sbjct: 315 ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEV 374

Query: 450 AEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNS 509
           AEKV +SS+PRE+QKAEE +VPEDSLEECAITCSNSHGP DSNQPH+   ITFEEDKV+S
Sbjct: 375 AEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 434

Query: 510 ALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQ 569
            L+    SSH E +DAV+I+P      + ++       GP+S      N+ E  E+  PQ
Sbjct: 435 TLI--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQ 483

Query: 570 LAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLK 629
                + +  L       +LA + +     +  EE + +  +V     ++ + K  +Q  
Sbjct: 484 -ESWDEGYSTLSIP--PERLASYQSYSSTFHSLEE-QQVCMAVDIGRHRWDQVKKEDQ-- 537

Query: 630 QAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQ 689
           +A   R  + L+  +E E+      L++  D   S       L    +P +S    L++Q
Sbjct: 538 EATGPRLSRELLDEKEPEV------LQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQ 591

Query: 690 LAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAP---REMQKAEEKEVPEDSL 746
                R+   +          D DE  + +  E+ Q  S P   RE+   +E EV +DSL
Sbjct: 592 -----RIGLAV----------DMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSL 636

Query: 747 EECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDE 806
           + C  T S      D  QP+R    + EE  +   L               +   + D E
Sbjct: 637 DRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLAL--------------DVDRIKKDQE 682

Query: 807 EEEEKGPVSP---RNLQESEEEEVPQESWD 833
           EEE++GP  P   R L E  E EV Q+S D
Sbjct: 683 EEEDQGPPCPRLSRELLEVVEPEVLQDSLD 712



 Score =  449 bits (1155), Expect = e-126
 Identities = 279/524 (53%), Positives = 340/524 (64%), Gaps = 41/524 (7%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
           MVVSAGP SSEKAE NILEINEKL PQLAE KQQFR+LKEKCFVTQ+A FLA +Q KYKY
Sbjct: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKY 256

Query: 61  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
           EECKDLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 257 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 316

Query: 121 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
           RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE AE
Sbjct: 317 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 376

Query: 181 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
           KV +SS+PRE+QKAEE +VPEDSLEECAITCSNSHGP DSNQPH+   ITFEEDKV+STL
Sbjct: 377 KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 436

Query: 241 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 300
           +    SSH E +DAV+I+P      + ++       GP+S      N+ E  E+  PQ  
Sbjct: 437 I--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQ-E 484

Query: 301 EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA 360
              + +  L       +LA + +     +  EE +  +   +   R    +++ ++ ++A
Sbjct: 485 SWDEGYSTLSIP--PERLASYQSYSSTFHSLEEQQVCMAVDIGRHRW---DQVKKEDQEA 539

Query: 361 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420
              R  + L+  +E E+      L++  D   S       L    +P +S    L++   
Sbjct: 540 TGPRLSRELLDEKEPEV------LQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQ--- 590

Query: 421 EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAP---REVQKAEESKVPEDSLEE 477
                     Q++    D DE E  Q  E E+  + S P   RE+   +E +V +DSL+ 
Sbjct: 591 ----------QRIGLAVDMDEIEKYQ--EVEEDQDPSCPRLSRELLAEKEPEVLQDSLDR 638

Query: 478 CAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDE 521
           C  T S      D  QP+++   + EE  +  AL VDR     E
Sbjct: 639 CYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQE 682



 Score =  231 bits (589), Expect = 3e-60
 Identities = 143/326 (43%), Positives = 188/326 (57%), Gaps = 34/326 (10%)

Query: 877  QVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQ 936
            +V ++ Q+++ PR   E+   +  EV +DSL+ C  T S      DS QP+R      E+
Sbjct: 373  EVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEE 429

Query: 937  QRVG-----------WALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRC 985
             +V            W   +  I + +  +E+++   P   R L + +E EV Q+S D  
Sbjct: 430  DKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEG 489

Query: 986  YSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL 1045
            YST S   E     Q Y S  +SLEEQ + +A+D+ R + DQ ++EDQ    PRLSRELL
Sbjct: 490  YSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELL 549

Query: 1046 EAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGK 1105
            +  EPEVLQDSLDRCYSTPS  L   DSC PY S+FY LE++ +G ++D+ EIEK     
Sbjct: 550  DEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY---- 605

Query: 1106 KRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFEL 1165
                            +E EEDQ+P CPRLS  L+  +EPEVLQDSLDRCYSTPS Y EL
Sbjct: 606  ----------------QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLEL 649

Query: 1166 PDSFQHYRSVFYSFEEQHISFALDVD 1191
            PD  Q YRS  YS EEQ++  ALDVD
Sbjct: 650  PDLGQPYRSAVYSLEEQYLGLALDVD 675



 Score = 34.3 bits (77), Expect = 0.74
 Identities = 21/67 (31%), Positives = 35/67 (52%)

Query: 1125 EEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHI 1184
            EED+          + + EE +V +DSL+ C  T S      DS Q ++++  +FEE  +
Sbjct: 102  EEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161

Query: 1185 SFALDVD 1191
            + +L VD
Sbjct: 162  NSSLVVD 168


>gi|157266285 hypothetical protein LOC728936 [Homo sapiens]
          Length = 670

 Score = 1271 bits (3290), Expect = 0.0
 Identities = 635/672 (94%), Positives = 649/672 (96%), Gaps = 2/672 (0%)

Query: 543  MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKY 602
            MVVSAGPLSSEKAEMNILE+NEKLRPQLAEKKQQFRNLKEKCF+TQLA FLAN+Q KYKY
Sbjct: 1    MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKY 60

Query: 603  EECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 662
            EECKDLIK +LRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDAS
Sbjct: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDAS 120

Query: 663  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAE 722
            RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRL Q L QKLSPENDND DEDVQVEVAE
Sbjct: 121  RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVAE 180

Query: 723  KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 782
            KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPH+KTKITFEEDKVDSTL
Sbjct: 181  KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHKKTKITFEEDKVDSTL 240

Query: 783  IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIP 842
            IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIP
Sbjct: 241  IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIP 300

Query: 843  PEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEV 902
            PEMLASYQSYS TFHSLEEQQVCMAVDIG HRWDQVKKEDQEATGPRLSRELLDEK PEV
Sbjct: 301  PEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEV 360

Query: 903  LQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSC 962
            LQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPSC
Sbjct: 361  LQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAIDMDEIEKYQEVEEDQDPSC 420

Query: 963  PRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDR 1022
            PRLSRELLDEKEPEVLQDSLDRCYSTPS YLELPDLGQPY SAVYSLEEQYLGLALDVDR
Sbjct: 421  PRLSRELLDEKEPEVLQDSLDRCYSTPSDYLELPDLGQPYSSAVYSLEEQYLGLALDVDR 480

Query: 1023 IKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFY 1082
            IKKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFY
Sbjct: 481  IKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFY 540

Query: 1083 ALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEV 1142
            ALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK+RRRGRKEGE+D NPPCPRL+G+LMEV
Sbjct: 541  ALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKKRRRGRKEGEDD-NPPCPRLNGVLMEV 598

Query: 1143 EEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVDNRFLTLMGTSL 1202
            EEPEVLQDSLDRCYST SMYFELPDSFQHYRSVFYSFEE+HISFAL VDNRF TL  TSL
Sbjct: 599  EEPEVLQDSLDRCYSTQSMYFELPDSFQHYRSVFYSFEEEHISFALYVDNRFFTLTVTSL 658

Query: 1203 HLVFQMGVIFPQ 1214
            HLVFQMGVIFPQ
Sbjct: 659  HLVFQMGVIFPQ 670



 Score =  549 bits (1415), Expect = e-156
 Identities = 350/699 (50%), Positives = 431/699 (61%), Gaps = 76/699 (10%)

Query: 272 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKY 331
           MVVSAGPLSSEKAEMNILE+NEKLRPQLAEKKQQFRNLKEKCF+TQLAGFLAN+Q KYKY
Sbjct: 1   MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKY 60

Query: 332 EECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 391
           EEC+DLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDAS
Sbjct: 61  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDAS 120

Query: 392 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 451
           RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRL QHLVQKLSPEND D+DEDVQVE AE
Sbjct: 121 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVAE 180

Query: 452 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL 511
           KV +SSAPRE+QKAEE +VPEDSLEECAITCSNSHGP DSNQPHK   ITFEEDKV+S L
Sbjct: 181 KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHKKTKITFEEDKVDSTL 240

Query: 512 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 571
           +    SSH E +DAV+I+P      + ++       GP+S      N+ E  E+  PQ  
Sbjct: 241 I--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQ-E 288

Query: 572 EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQA 631
              + +  L        LA + +     +  EE + +  +V     ++ + K  +Q  +A
Sbjct: 289 SWDEGYSTLSIP--PEMLASYQSYSSTFHSLEE-QQVCMAVDIGRHRWDQVKKEDQ--EA 343

Query: 632 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 691
              R  + L+  +E E+      L++  D   S       L    +P +S    L++Q  
Sbjct: 344 TGPRLSRELLDEKEPEV------LQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ-- 395

Query: 692 EGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAP---REMQKAEEKEVPEDSLEE 748
              R+   +          D DE  + +  E+ Q  S P   RE+   +E EV +DSL+ 
Sbjct: 396 ---RVGLAI----------DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDR 442

Query: 749 CAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEE 808
           C  T S+     D  QP+     + EE  +   L               +   + D EEE
Sbjct: 443 CYSTPSDYLELPDLGQPYSSAVYSLEEQYLGLAL--------------DVDRIKKDQEEE 488

Query: 809 EEKGPVSP---RNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVC 865
           E++GP  P   R L E  E EV Q+S D  YST S   E   S Q Y  +F++LEE+ V 
Sbjct: 489 EDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVG 548

Query: 866 MAVDIG------------GHRWDQVKK------EDQEATGPRLSRELLDEKGPEVLQDSL 907
            ++D+G            G R  + ++      ED     PRL+  L++ + PEVLQDSL
Sbjct: 549 FSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEDDNPPCPRLNGVLMEVEEPEVLQDSL 608

Query: 908 DRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMD 946
           DRCYST S Y EL DS Q YRS FY  E++ + +AL +D
Sbjct: 609 DRCYSTQSMYFELPDSFQHYRSVFYSFEEEHISFALYVD 647



 Score =  465 bits (1196), Expect = e-130
 Identities = 285/524 (54%), Positives = 343/524 (65%), Gaps = 41/524 (7%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
           MVVSAGP SSEKAE NILEINEKLRPQLAE KQQFRNLKEKCF+TQLAGFLANRQKKYKY
Sbjct: 1   MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKY 60

Query: 61  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
           EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDAS
Sbjct: 61  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDAS 120

Query: 121 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
           RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRL QHLVQKLSPEND D+DEDVQVE AE
Sbjct: 121 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVAE 180

Query: 181 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
           KV +SSAPRE+QKAEE +VPEDSLEECAITCSNSHGP DSNQPHK   ITFEEDKV+STL
Sbjct: 181 KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHKKTKITFEEDKVDSTL 240

Query: 241 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 300
           +    SSH E +DAV+I+P      + ++       GP+S      N+ E  E+  PQ  
Sbjct: 241 I--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQ-E 288

Query: 301 EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA 360
              + +  L        LA + +     +  EE +  +   +   R    +++ ++ ++A
Sbjct: 289 SWDEGYSTLSIP--PEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRW---DQVKKEDQEA 343

Query: 361 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420
              R  + L+  +E E+      L++  D   S       L    +P +S    L++Q  
Sbjct: 344 TGPRLSRELLDEKEPEV------LQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRV 397

Query: 421 EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAP---REVQKAEESKVPEDSLEE 477
            G  +              D DE  + +E E+  + S P   RE+   +E +V +DSL+ 
Sbjct: 398 -GLAI--------------DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDR 442

Query: 478 CAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDE 521
           C  T S+     D  QP+ +   + EE  +  AL VDR     E
Sbjct: 443 CYSTPSDYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQE 486



 Score = 33.9 bits (76), Expect = 0.97
 Identities = 18/53 (33%), Positives = 31/53 (58%)

Query: 191 VQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVD 243
           + + EE +V +DSL+ C  T S      DS Q ++++  +FEE+ ++  L VD
Sbjct: 595 LMEVEEPEVLQDSLDRCYSTQSMYFELPDSFQHYRSVFYSFEEEHISFALYVD 647



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 36/158 (22%), Positives = 65/158 (41%), Gaps = 13/158 (8%)

Query: 90  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDE----PDKSQGQDLQ 145
           +E+ +Y+ +   Q+    +L  +L + ++     +   +   TP +    PD  Q     
Sbjct: 404 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSDYLELPDLGQPYSSA 463

Query: 146 EQLAEGCRLAQHL-VQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSL 204
               E   L   L V ++  + +E+ED+                RE+ +  E +V +DSL
Sbjct: 464 VYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVLQDSL 515

Query: 205 EECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVV 242
           + C  T S+     DS QP+ +     EE  V  +L V
Sbjct: 516 DRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDV 553


>gi|29789405 hypothetical protein LOC284565 [Homo sapiens]
          Length = 670

 Score = 1268 bits (3281), Expect = 0.0
 Identities = 634/672 (94%), Positives = 647/672 (96%), Gaps = 2/672 (0%)

Query: 543  MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKY 602
            MVVSAGPLSSEKAEMNILE+NEKLRPQLAEKKQQFRNLKEKCF+TQLA FLAN+Q KYKY
Sbjct: 1    MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKY 60

Query: 603  EECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 662
            EECKDLIK +LRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDAS
Sbjct: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDAS 120

Query: 663  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAE 722
            RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRL Q L QKLSPENDND DEDVQVEVAE
Sbjct: 121  RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVAE 180

Query: 723  KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 782
            KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPH+KTKITFEEDKVDSTL
Sbjct: 181  KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHKKTKITFEEDKVDSTL 240

Query: 783  IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIP 842
            IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIP
Sbjct: 241  IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIP 300

Query: 843  PEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEV 902
            PEMLASYQSYS TFHSLEEQQVCMAVDIG HRWDQVKKEDQEATGPRLSRELLDEK PEV
Sbjct: 301  PEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEV 360

Query: 903  LQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSC 962
            LQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPSC
Sbjct: 361  LQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAIDMDEIEKYQEVEEDQDPSC 420

Query: 963  PRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDR 1022
            PRLSRELLDEKEPEVLQDSLDRCYSTPS YLELPDLGQPY SAVYSLEEQYLGLAL VDR
Sbjct: 421  PRLSRELLDEKEPEVLQDSLDRCYSTPSDYLELPDLGQPYSSAVYSLEEQYLGLALAVDR 480

Query: 1023 IKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFY 1082
            IKKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFY
Sbjct: 481  IKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFY 540

Query: 1083 ALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEV 1142
            ALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK+RRRGRKEGE+D NPPCPRL G+LMEV
Sbjct: 541  ALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKKRRRGRKEGEDD-NPPCPRLYGVLMEV 598

Query: 1143 EEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVDNRFLTLMGTSL 1202
            EEPEVLQDSLDRCYSTPSMYFE PDSFQHYRSVFYSFEE+HISFAL VDNRF TL  TSL
Sbjct: 599  EEPEVLQDSLDRCYSTPSMYFEQPDSFQHYRSVFYSFEEEHISFALYVDNRFFTLTVTSL 658

Query: 1203 HLVFQMGVIFPQ 1214
            HLVFQMGVIFPQ
Sbjct: 659  HLVFQMGVIFPQ 670



 Score =  550 bits (1416), Expect = e-156
 Identities = 350/699 (50%), Positives = 430/699 (61%), Gaps = 76/699 (10%)

Query: 272 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKY 331
           MVVSAGPLSSEKAEMNILE+NEKLRPQLAEKKQQFRNLKEKCF+TQLAGFLAN+Q KYKY
Sbjct: 1   MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKY 60

Query: 332 EECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 391
           EEC+DLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDAS
Sbjct: 61  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDAS 120

Query: 392 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 451
           RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRL QHLVQKLSPEND D+DEDVQVE AE
Sbjct: 121 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVAE 180

Query: 452 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL 511
           KV +SSAPRE+QKAEE +VPEDSLEECAITCSNSHGP DSNQPHK   ITFEEDKV+S L
Sbjct: 181 KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHKKTKITFEEDKVDSTL 240

Query: 512 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 571
           +    SSH E +DAV+I+P      + ++       GP+S      N+ E  E+  PQ  
Sbjct: 241 I--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQ-E 288

Query: 572 EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQA 631
              + +  L        LA + +     +  EE + +  +V     ++ + K  +Q  +A
Sbjct: 289 SWDEGYSTLSIP--PEMLASYQSYSSTFHSLEE-QQVCMAVDIGRHRWDQVKKEDQ--EA 343

Query: 632 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 691
              R  + L+  +E E+      L++  D   S       L    +P +S    L++Q  
Sbjct: 344 TGPRLSRELLDEKEPEV------LQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ-- 395

Query: 692 EGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAP---REMQKAEEKEVPEDSLEE 748
              R+   +          D DE  + +  E+ Q  S P   RE+   +E EV +DSL+ 
Sbjct: 396 ---RVGLAI----------DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDR 442

Query: 749 CAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEE 808
           C  T S+     D  QP+     + EE  +   L               +   + D EEE
Sbjct: 443 CYSTPSDYLELPDLGQPYSSAVYSLEEQYLGLAL--------------AVDRIKKDQEEE 488

Query: 809 EEKGPVSP---RNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVC 865
           E++GP  P   R L E  E EV Q+S D  YST S   E   S Q Y  +F++LEE+ V 
Sbjct: 489 EDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVG 548

Query: 866 MAVDIG------------GHRWDQVKK------EDQEATGPRLSRELLDEKGPEVLQDSL 907
            ++D+G            G R  + ++      ED     PRL   L++ + PEVLQDSL
Sbjct: 549 FSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEDDNPPCPRLYGVLMEVEEPEVLQDSL 608

Query: 908 DRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMD 946
           DRCYSTPS Y E  DS Q YRS FY  E++ + +AL +D
Sbjct: 609 DRCYSTPSMYFEQPDSFQHYRSVFYSFEEEHISFALYVD 647



 Score =  466 bits (1199), Expect = e-131
 Identities = 285/524 (54%), Positives = 343/524 (65%), Gaps = 41/524 (7%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
           MVVSAGP SSEKAE NILEINEKLRPQLAE KQQFRNLKEKCF+TQLAGFLANRQKKYKY
Sbjct: 1   MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKY 60

Query: 61  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
           EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDAS
Sbjct: 61  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDAS 120

Query: 121 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
           RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRL QHLVQKLSPEND D+DEDVQVE AE
Sbjct: 121 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVAE 180

Query: 181 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
           KV +SSAPRE+QKAEE +VPEDSLEECAITCSNSHGP DSNQPHK   ITFEEDKV+STL
Sbjct: 181 KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHKKTKITFEEDKVDSTL 240

Query: 241 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 300
           +    SSH E +DAV+I+P      + ++       GP+S      N+ E  E+  PQ  
Sbjct: 241 I--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQ-E 288

Query: 301 EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA 360
              + +  L        LA + +     +  EE +  +   +   R    +++ ++ ++A
Sbjct: 289 SWDEGYSTLSIP--PEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRW---DQVKKEDQEA 343

Query: 361 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420
              R  + L+  +E E+      L++  D   S       L    +P +S    L++Q  
Sbjct: 344 TGPRLSRELLDEKEPEV------LQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRV 397

Query: 421 EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAP---REVQKAEESKVPEDSLEE 477
            G  +              D DE  + +E E+  + S P   RE+   +E +V +DSL+ 
Sbjct: 398 -GLAI--------------DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDR 442

Query: 478 CAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDE 521
           C  T S+     D  QP+ +   + EE  +  AL VDR     E
Sbjct: 443 CYSTPSDYLELPDLGQPYSSAVYSLEEQYLGLALAVDRIKKDQE 486



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 40/162 (24%), Positives = 69/162 (42%), Gaps = 21/162 (12%)

Query: 90  EELRQYKVLVHSQERELTQLREKLREGRDAS-------RSLNQHLQALLTPD--EPDKSQ 140
           +E+ +Y+ +   Q+    +L  +L + ++         R  +     L  PD  +P  S 
Sbjct: 404 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSDYLELPDLGQPYSSA 463

Query: 141 GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVP 200
              L+EQ   G  LA   V ++  + +E+ED+                RE+ +  E +V 
Sbjct: 464 VYSLEEQYL-GLALA---VDRIKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVL 511

Query: 201 EDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVV 242
           +DSL+ C  T S+     DS QP+ +     EE  V  +L V
Sbjct: 512 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDV 553



 Score = 34.7 bits (78), Expect = 0.57
 Identities = 18/53 (33%), Positives = 31/53 (58%)

Query: 191 VQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVD 243
           + + EE +V +DSL+ C  T S      DS Q ++++  +FEE+ ++  L VD
Sbjct: 595 LMEVEEPEVLQDSLDRCYSTPSMYFEQPDSFQHYRSVFYSFEEEHISFALYVD 647


>gi|169162915 PREDICTED: hypothetical protein LOC728841 [Homo sapiens]
          Length = 3815

 Score = 1226 bits (3172), Expect = 0.0
 Identities = 612/662 (92%), Positives = 628/662 (94%), Gaps = 1/662 (0%)

Query: 530  PVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQL 589
            PVPGPTSSATNVSMVVSAGPLSSEKAEMNILE+NEKL PQLAEKKQQFRNLKE+CFVTQL
Sbjct: 8    PVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKERCFVTQL 67

Query: 590  ACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELT 649
            A FLANQQ KYKYEECKDLIKS+LRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELT
Sbjct: 68   AGFLANQQKKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELT 127

Query: 650  QLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPEND 709
            QLREKLREGRDASRSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQ L QKLSPEND
Sbjct: 128  QLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND 187

Query: 710  NDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKT 769
            ND DEDVQVE+AEKVQKSSAPREMQKAEEKEVPEDS EECAIT SNSHGPYDSNQPHRKT
Sbjct: 188  NDDDEDVQVELAEKVQKSSAPREMQKAEEKEVPEDSQEECAITYSNSHGPYDSNQPHRKT 247

Query: 770  KITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQ 829
            KITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQ
Sbjct: 248  KITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQ 307

Query: 830  ESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPR 889
            ESWDEGYSTLSIPPEMLASYQSYS TFHSLEEQQVCMAVDIG HRWDQVKKEDQEATGPR
Sbjct: 308  ESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPR 367

Query: 890  LSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIE 949
            LSRELLDEKGPEVLQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQR+G A+DMDEIE
Sbjct: 368  LSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRIGLAVDMDEIE 427

Query: 950  KYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSL 1009
            KYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSL
Sbjct: 428  KYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSL 487

Query: 1010 EEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLE 1069
            EEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLE
Sbjct: 488  EEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLE 547

Query: 1070 QPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQN 1129
            QPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQN
Sbjct: 548  QPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQN 606

Query: 1130 PPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALD 1189
            PPCPRLS  L++ + PEVLQDSLDRCYSTPS   EL DS Q YRS FY  E+Q +  A+D
Sbjct: 607  PPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVD 666

Query: 1190 VD 1191
            +D
Sbjct: 667  MD 668



 Score = 1058 bits (2735), Expect = 0.0
 Identities = 603/968 (62%), Positives = 675/968 (69%), Gaps = 98/968 (10%)

Query: 259  PVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQL 318
            PVPGPTSSATNVSMVVSAGPLSSEKAEMNILE+NEKL PQLAEKKQQFRNLKE+CFVTQL
Sbjct: 8    PVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKERCFVTQL 67

Query: 319  AGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELT 378
            AGFLANQQ KYKYEEC+DLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELT
Sbjct: 68   AGFLANQQKKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELT 127

Query: 379  QLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND 438
            QLREKLREGRDASRSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND
Sbjct: 128  QLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND 187

Query: 439  EDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNI 498
             D+DEDVQVE AEKV +SSAPRE+QKAEE +VPEDS EECAIT SNSHGP DSNQPH+  
Sbjct: 188  NDDDEDVQVELAEKVQKSSAPREMQKAEEKEVPEDSQEECAITYSNSHGPYDSNQPHRKT 247

Query: 499  NITFEEDKVNSALVVDRESSHDECQDAVNILPV----------PGPTSSATNVSMVVSAG 548
             ITFEEDKV+S L+    SSH E +DAV+I+P            GP S            
Sbjct: 248  KITFEEDKVDSTLI--GSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEV 305

Query: 549  PLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDL 608
            P  S     + L +  ++          F +L+E     Q  C +A    ++++++ K  
Sbjct: 306  PQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEE-----QQVC-MAVDIGRHRWDQVK-- 357

Query: 609  IKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQH 668
                       KE++ A   + + EL   K              E L++  D   S    
Sbjct: 358  -----------KEDQEATGPRLSRELLDEKG------------PEVLQDSLDRCYSTPSG 394

Query: 669  LQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSS 728
               L    +P +S    L++Q     R+   +          D DE  + +  E+ Q  S
Sbjct: 395  CLELTDSCQPYRSAFYVLEQQ-----RIGLAV----------DMDEIEKYQEVEEDQDPS 439

Query: 729  APR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGS 785
             PR   E+   +E EV +DSL+ C  T S      D  QP+     + EE  +   L   
Sbjct: 440  CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD-- 497

Query: 786  SSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIP 842
                        +   + D EEEE++GP  PR    L E  E EV Q+S D  YST S  
Sbjct: 498  ------------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSC 545

Query: 843  PEMLASYQSYSGTFHSLEEQQVCMAVDIG------------GHRWDQVKK-------EDQ 883
             E   S Q Y  +F++LEE+ V  ++D+G            G R  + ++       EDQ
Sbjct: 546  LEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQ 605

Query: 884  EATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWAL 943
                PRLSRELLDEKGPEVLQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQRVG A+
Sbjct: 606  NPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAV 665

Query: 944  DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYR 1003
            DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY 
Sbjct: 666  DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 725

Query: 1004 SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYST 1063
            SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYST
Sbjct: 726  SAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYST 785

Query: 1064 PSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKE 1123
            PSSCLEQPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKE
Sbjct: 786  PSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKE 844

Query: 1124 GEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQH 1183
            GEEDQNPPCPRLS  L++ +EPEVLQDSLDRCYSTPS Y ELPD  Q Y S  YS EEQ+
Sbjct: 845  GEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQY 904

Query: 1184 ISFALDVD 1191
            +  ALDVD
Sbjct: 905  LGLALDVD 912



 Score = 1021 bits (2639), Expect = 0.0
 Identities = 636/1235 (51%), Positives = 754/1235 (61%), Gaps = 143/1235 (11%)

Query: 1    MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
            MVVSAGP SSEKAE NILEINEKL PQLAE KQQFRNLKE+CFVTQLAGFLAN+QKKYKY
Sbjct: 21   MVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKERCFVTQLAGFLANQQKKYKY 80

Query: 61   EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
            EECKDLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDAS
Sbjct: 81   EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDAS 140

Query: 121  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
            RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE AE
Sbjct: 141  RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVELAE 200

Query: 181  KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
            KV +SSAPRE+QKAEE +VPEDS EECAIT SNSHGP DSNQPH+   ITFEEDKV+STL
Sbjct: 201  KVQKSSAPREMQKAEEKEVPEDSQEECAITYSNSHGPYDSNQPHRKTKITFEEDKVDSTL 260

Query: 241  VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 300
            +    SSH E +DAV+I+P      + ++       GP+S      N+ E  E+  PQ +
Sbjct: 261  I--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQES 309

Query: 301  -EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEE---CEDLIKSMLRNERQFKEEKLAEQ 356
             ++     ++  +     LA + +     +  EE   C  +     R ++  KE++ A  
Sbjct: 310  WDEGYSTLSIPPE----MLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATG 365

Query: 357  LKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQ 416
             + + EL   K              E L++  D   S       L    +P +S    L+
Sbjct: 366  PRLSRELLDEKG------------PEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLE 413

Query: 417  EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPED 473
            +Q             ++    D DE E  Q  E E+  + S PR   E+   +E +V +D
Sbjct: 414  QQ-------------RIGLAVDMDEIEKYQ--EVEEDQDPSCPRLSRELLDEKEPEVLQD 458

Query: 474  SLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPG 533
            SL+ C  T S      D  QP+ +   + EE  +  AL VDR     E ++         
Sbjct: 459  SLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE--------- 509

Query: 534  PTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFL 593
                          GP     +     E+ E + P++ +         ++C+ T  +C  
Sbjct: 510  ------------DQGPPCPRLSR----ELLEVVEPEVLQDSL------DRCYSTPSSCL- 546

Query: 594  ANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLRE 653
                      E  D  +    +    +E+ +   L   E  ++ K       R   + R 
Sbjct: 547  ----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRR 596

Query: 654  KLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE---------QLAEGCRLAQQLFQKL 704
              +EG +        L   L  ++  +     L           +L + C+  +  F  L
Sbjct: 597  GRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVL 656

Query: 705  SPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPEDSLEECAITCSNSHG 758
              +      D DE  + +  E+ Q  S PR   E+   +E EV +DSL+ C  T S    
Sbjct: 657  EQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLE 716

Query: 759  PYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR- 817
              D  QP+     + EE  +   L               +   + D EEEE++GP  PR 
Sbjct: 717  LPDLGQPYSSAVYSLEEQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRL 762

Query: 818  --NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIG---- 871
               L E  E EV Q+S D  YST S   E   S Q Y  +F++LEE+ V  ++D+G    
Sbjct: 763  SRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEK 822

Query: 872  --------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSG 916
                    G R  + ++       EDQ    PRLSRELLDEK PEVLQDSLDRCYSTPSG
Sbjct: 823  KGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSG 882

Query: 917  YLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPE 976
            YLEL D  QPY SA Y LE+Q +G ALD+DEIEKYQEVEEDQDPSCPRLSRELLDEKEPE
Sbjct: 883  YLELPDLGQPYSSAVYSLEEQYLGLALDVDEIEKYQEVEEDQDPSCPRLSRELLDEKEPE 942

Query: 977  VLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPP 1036
            VLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPP
Sbjct: 943  VLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPP 1002

Query: 1037 CPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVG 1096
            CPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALEEKHVGFSLDVG
Sbjct: 1003 CPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVG 1062

Query: 1097 EIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCY 1156
            EIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ +EPEVLQDSLDRCY
Sbjct: 1063 EIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCY 1121

Query: 1157 STPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            STPS Y ELPD  Q Y S  YS EEQ++  ALDVD
Sbjct: 1122 STPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 1156



 Score =  643 bits (1658), Expect = 0.0
 Identities = 456/1070 (42%), Positives = 566/1070 (52%), Gaps = 138/1070 (12%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 1661 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 1720

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 1721 SAVYSLEEQYLGLALDVDRTKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 1777

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 1778 YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 1822

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D   S       L
Sbjct: 1823 KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL 1881

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q             ++    D DE E  Q  E E+  + S PR 
Sbjct: 1882 TDSCQPYRSAFYVLEQQ-------------RVGLAVDMDEIEKYQ--EVEEDQDPSCPRL 1926

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 1927 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKK 1986

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 578
              E ++                       GP     +     E+ E + P++ +      
Sbjct: 1987 DQEEEE---------------------DQGPPCPRLSR----ELLEVVEPEVLQDSL--- 2018

Query: 579  NLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
               ++C+ T  +C            E  D  +    +    +E+ +   L   E  ++ K
Sbjct: 2019 ---DRCYSTPSSCL-----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGK 2064

Query: 639  VLVHSQERELTQLREKLREGRD--------ASRSLNQHLQALLTPDEPDKSQGQDLQ-EQ 689
                   R   + R   +EG +         SR L       +  D  D+S        +
Sbjct: 2065 GKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLE 2124

Query: 690  LAEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPE 743
            L + C+  +  F  L  +      D DE  + +  E+ Q  S PR   E+   +E EV +
Sbjct: 2125 LTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQ 2184

Query: 744  DSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENES 803
            DSL+ C  T S      D  QP+     + EE  +   L               +   + 
Sbjct: 2185 DSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------------VDRTKK 2230

Query: 804  DDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLE 860
            D EEEE++GP  PR    L E  E EV Q+S D  YST S   E   S Q Y  +F++LE
Sbjct: 2231 DQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALE 2290

Query: 861  EQQVCMAVDIG------------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPE 901
            E+ V  ++D+G            G R  + ++       EDQ    PRLSRELLDEKGPE
Sbjct: 2291 EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPE 2350

Query: 902  VLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPS 961
            VLQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPS
Sbjct: 2351 VLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPS 2410

Query: 962  CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 1021
            CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVD
Sbjct: 2411 CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 2470

Query: 1022 RIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSF 1081
            R KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSF
Sbjct: 2471 RTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSF 2530

Query: 1082 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLME 1141
            YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++
Sbjct: 2531 YALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLD 2589

Query: 1142 VEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
             +EPEVLQDSLDRCYSTPS Y ELPD  Q Y S  YS EEQ++  ALDVD
Sbjct: 2590 EKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 2639



 Score =  613 bits (1580), Expect = e-175
 Identities = 377/769 (49%), Positives = 450/769 (58%), Gaps = 94/769 (12%)

Query: 460  REVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSH 519
            RE+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR    
Sbjct: 1440 RELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKD 1499

Query: 520  DECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRN 579
             E ++                       GP     +     E+ E + P++ +       
Sbjct: 1500 QEEEE---------------------DQGPPCPRLSR----ELLEVVEPEVLQDSL---- 1530

Query: 580  LKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKV 639
              ++C+ T  +C            E  D  +    +    +E+ +   L   E  ++ K 
Sbjct: 1531 --DRCYSTPSSCL-----------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKG 1577

Query: 640  LVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE---------QL 690
                  R   + R   +EG +        L   L  ++  +     L           +L
Sbjct: 1578 KKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL 1637

Query: 691  AEGCRLAQQLFQKLSPENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPED 744
             + C+  +  F  L  +      D DE  + +  E+ Q  S PR   E+   +E EV +D
Sbjct: 1638 TDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQD 1697

Query: 745  SLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD 804
            SL+ C  T S      D  QP+     + EE  +   L               +   + D
Sbjct: 1698 SLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------------VDRTKKD 1743

Query: 805  DEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEE 861
             EEEE++GP  PR    L E  E EV Q+S D  YST S   E   S Q Y  +F++LEE
Sbjct: 1744 QEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEE 1803

Query: 862  QQVCMAVDIG------------GHRWDQVKK-------EDQEATGPRLSRELLDEKGPEV 902
            + V  ++D+G            G R  + ++       EDQ    PRLSRELLDEKGPEV
Sbjct: 1804 KHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEV 1863

Query: 903  LQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSC 962
            LQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEIEKYQEVEEDQDPSC
Sbjct: 1864 LQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSC 1923

Query: 963  PRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDR 1022
            PRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR
Sbjct: 1924 PRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDR 1983

Query: 1023 IKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFY 1082
             KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFY
Sbjct: 1984 TKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFY 2043

Query: 1083 ALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEV 1142
            ALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ 
Sbjct: 2044 ALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDE 2102

Query: 1143 EEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            + PEVLQDSLDR YSTPS   EL DS Q YRS FY  E+Q +  A+D+D
Sbjct: 2103 KGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 2151



 Score =  611 bits (1575), Expect = e-174
 Identities = 329/483 (68%), Positives = 358/483 (74%), Gaps = 37/483 (7%)

Query: 731  REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVE 790
            RE+   +E EV +DSL+ C  T S      D  QP+     + EE  +   L        
Sbjct: 2585 RELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD------- 2637

Query: 791  WEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLA 847
                   +   + D EEEE++GP  PR    L E  E EV Q+S D  YST S   E   
Sbjct: 2638 -------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPD 2690

Query: 848  SYQSYSGTFHSLEEQQVCMAVDIG------------GHRWDQVKK-------EDQEATGP 888
            S Q Y  +F++LEE+ V  ++D+G            G R  + ++       EDQ    P
Sbjct: 2691 SCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCP 2750

Query: 889  RLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEI 948
            RLSRELLDEKGPEVLQDSLDRCYSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEI
Sbjct: 2751 RLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEI 2810

Query: 949  EKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYS 1008
            EKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYS
Sbjct: 2811 EKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYS 2870

Query: 1009 LEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCL 1068
            LEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCL
Sbjct: 2871 LEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCL 2930

Query: 1069 EQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQ 1128
            EQPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQ
Sbjct: 2931 EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQ 2989

Query: 1129 NPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFAL 1188
            NPPCPRLS  L++ +EPEVLQDSLDRCYSTPS Y ELPD  Q Y S  YS EEQ++  AL
Sbjct: 2990 NPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLAL 3049

Query: 1189 DVD 1191
            DVD
Sbjct: 3050 DVD 3052



 Score =  605 bits (1559), Expect = e-172
 Identities = 326/495 (65%), Positives = 361/495 (72%), Gaps = 37/495 (7%)

Query: 731  REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVE 790
            RE+   +E EV +DSL+ C  T S      D  QP+     + EE  +   L        
Sbjct: 3336 RELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD------- 3388

Query: 791  WEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLA 847
                   +   + D EEEE++GP  PR    L E  E EV Q+S D  YST S   E   
Sbjct: 3389 -------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPD 3441

Query: 848  SYQSYSGTFHSLEEQQVCMAVDIG------------GHRWDQVKK-------EDQEATGP 888
            S Q Y  +F++LEE+ V  ++D+G            G R  + ++       EDQ    P
Sbjct: 3442 SCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCP 3501

Query: 889  RLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEI 948
            RLSRELLDEKGPEVLQDSLDR YSTPSG LELTDSCQPYRSAFY+LEQQRVG A+DMDEI
Sbjct: 3502 RLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEI 3561

Query: 949  EKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYS 1008
            EKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYS
Sbjct: 3562 EKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYS 3621

Query: 1009 LEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCL 1068
            LEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCL
Sbjct: 3622 LEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCL 3681

Query: 1069 EQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQ 1128
            EQPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQ
Sbjct: 3682 EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQ 3740

Query: 1129 NPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFAL 1188
            NPPCPRLS  L++ + PEVLQDSLDRCYSTPS   EL DS Q YRS FY  E+Q +  A+
Sbjct: 3741 NPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAV 3800

Query: 1189 DVDNRFLTLMGTSLH 1203
            D+D  +L++    +H
Sbjct: 3801 DMDGEYLSMKVIRIH 3815



 Score =  585 bits (1508), Expect = e-167
 Identities = 447/1117 (40%), Positives = 573/1117 (51%), Gaps = 138/1117 (12%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 422  DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 481

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 482  SAVYSLEEQYLGLALDVDRTKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 538

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 539  YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 583

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D   S       L
Sbjct: 584  KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLEL 642

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P +S    L++Q             ++    D DE E  Q  E E+  + S PR 
Sbjct: 643  TDSCQPYRSAFYVLEQQ-------------RVGLAVDMDEIEKYQ--EVEEDQDPSCPRL 687

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 688  SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKK 747

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS----EKAEMNILEMNEKLRPQLAEKK 574
              E ++       P P  S   + +V       S         + LE  +  +P      
Sbjct: 748  DQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY----G 800

Query: 575  QQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEE------KLAEQL 628
              F  L+EK     L      ++ K K    +   K   R  ++ +E+      +L+ +L
Sbjct: 801  SSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSREL 860

Query: 629  ---KQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLN-QHLQALLTPDEPDKSQGQ 684
               K+ E L+      +S      +L +  +    A  SL  Q+L   L  DE +K Q  
Sbjct: 861  LDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDEIEKYQ-- 918

Query: 685  DLQEQLAEGC-RLAQQLFQKLSPENDNDH------------------------------- 712
            +++E     C RL+++L  +  PE   D                                
Sbjct: 919  EVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQ 978

Query: 713  ------DEDVQVEVAEKVQKSSAP-----REMQKAEEKEVPEDSLEECAITCSNSHGPYD 761
                  D D   +  E+ +    P     RE+ +  E EV +DSL+ C  T S+     D
Sbjct: 979  YLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPD 1038

Query: 762  SNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSP 816
            S QP+  +    EE  V  +L       + +        ++ +      E EE++ P  P
Sbjct: 1039 SCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCP 1098

Query: 817  R---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGH 873
            R    L + +E EV Q+S D  YST S   E+    Q YS   +SLEEQ + +A+D+   
Sbjct: 1099 RLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRT 1158

Query: 874  RWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYI 933
            + DQ ++EDQ    PRLSRELL+   PEVLQDSLDRCYSTPS  LE  DSCQPY S+FY 
Sbjct: 1159 KKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYA 1218

Query: 934  LEQQRVGWALDMDEIEKY-------------------QEVEEDQDPSCPRLSRELLDEKE 974
            LE++ VG++LD+ EIEK                    +E EEDQ+P CPRLSRELLDEKE
Sbjct: 1219 LEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKE 1278

Query: 975  PEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQG 1034
            PEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQG
Sbjct: 1279 PEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQG 1338

Query: 1035 PPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLD 1094
            PPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALEEKHVGFSLD
Sbjct: 1339 PPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLD 1398

Query: 1095 VGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDR 1154
            VGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ +EPEVLQDSLDR
Sbjct: 1399 VGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDR 1457

Query: 1155 CYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            CYSTPS Y ELPD  Q Y S  YS EEQ++  ALDVD
Sbjct: 1458 CYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 1494



 Score =  580 bits (1494), Expect = e-165
 Identities = 436/1067 (40%), Positives = 551/1067 (51%), Gaps = 113/1067 (10%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 666  DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 725

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 726  SAVYSLEEQYLGLALDVDRTKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 782

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 783  YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 827

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D   S       L
Sbjct: 828  KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLEL 886

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR- 460
                +P  S    L+EQ   G  L              D DE  + +E E+  + S PR 
Sbjct: 887  PDLGQPYSSAVYSLEEQYL-GLAL--------------DVDEIEKYQEVEEDQDPSCPRL 931

Query: 461  --EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESS 518
              E+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VDR   
Sbjct: 932  SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKK 991

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS----EKAEMNILEMNEKLRPQLAEKK 574
              E ++       P P  S   + +V       S         + LE  +  +P      
Sbjct: 992  DQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY----G 1044

Query: 575  QQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEEL 634
              F  L+EK     L      ++ K K    +   K   R  ++ +E++     + + EL
Sbjct: 1045 SSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSREL 1104

Query: 635  RQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGC 694
               K              E L++  D   S       L    +P  S    L+EQ   G 
Sbjct: 1105 LDEKE------------PEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL-GL 1151

Query: 695  RLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPEDSLEECAI 751
             L     +K     D + +ED         Q    PR   E+ +  E EV +DSL+ C  
Sbjct: 1152 ALDVDRTKK-----DQEEEED---------QGPPCPRLSRELLEVVEPEVLQDSLDRCYS 1197

Query: 752  TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DE 806
            T S+     DS QP+  +    EE  V  +L       + +        ++ +      E
Sbjct: 1198 TPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKE 1257

Query: 807  EEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQ 863
             EE++ P  PR    L + +E EV Q+S D  YST S   E+    Q YS   +SLEEQ 
Sbjct: 1258 GEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQY 1317

Query: 864  VCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDS 923
            + +A+D+   + DQ ++EDQ    PRLSRELL+   PEVLQDSLDRCYSTPS  LE  DS
Sbjct: 1318 LGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDS 1377

Query: 924  CQPYRSAFYILEQQRVGWALDMDEIEKY-------------------QEVEEDQDPSCPR 964
            CQPY S+FY LE++ VG++LD+ EIEK                    +E EEDQ+P CPR
Sbjct: 1378 CQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPR 1437

Query: 965  LSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIK 1024
            LSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR K
Sbjct: 1438 LSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTK 1497

Query: 1025 KDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYAL 1084
            KDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFYAL
Sbjct: 1498 KDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYAL 1557

Query: 1085 EEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEE 1144
            EEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ + 
Sbjct: 1558 EEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDEKG 1616

Query: 1145 PEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            PEVLQDSLDRCYSTPS   EL DS Q YRS FY  E+Q +  A+D+D
Sbjct: 1617 PEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 1663



 Score =  579 bits (1492), Expect = e-165
 Identities = 422/1066 (39%), Positives = 553/1066 (51%), Gaps = 111/1066 (10%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 2393 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 2452

Query: 226  NINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS---- 281
            +   + EE  +   L VDR     E ++       P P  S   + +V       S    
Sbjct: 2453 SAVYSLEEQYLGLALDVDRTKKDQEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRC 2509

Query: 282  EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
                 + LE  +  +P        F  L+EK       GF  +        E E   K  
Sbjct: 2510 YSTPSSCLEQPDSCQPY----GSSFYALEEKH-----VGFSLD------VGEIEKKGKGK 2554

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             R  R+ K+E+   + K+ EE +       S+E    +  E L++  D   S       L
Sbjct: 2555 KRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLEL 2613

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPRE 461
                +P  S    L+EQ   G  L    V +   + +E+ED+                RE
Sbjct: 2614 PDLGQPYSSAVYSLEEQYL-GLALD---VDRTKKDQEEEEDQGPPCPRLS--------RE 2661

Query: 462  VQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDE 521
            + +  E +V +DSL+ C  T S+     DS QP+ +     EE  V  +L V       +
Sbjct: 2662 LLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGK 2721

Query: 522  CQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRP-------QLAEKK 574
             +                        G  S ++      E  E   P       +L ++K
Sbjct: 2722 GKKR---------------------RGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEK 2760

Query: 575  --QQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAE 632
              +  ++  ++C+ T   C           + C+       R+     E++        +
Sbjct: 2761 GPEVLQDSLDRCYSTPSGCLELT-------DSCQPY-----RSAFYVLEQQRVGLAVDMD 2808

Query: 633  ELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAE 692
            E+ +Y+ +   Q+    +L  +L + ++     +   +   TP      +  DL +  + 
Sbjct: 2809 EIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPS--GYLELPDLGQPYSS 2866

Query: 693  GCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAIT 752
                 ++ +  L+ + D    +D + E  +        RE+ +  E EV +DSL+ C  T
Sbjct: 2867 AVYSLEEQYLGLALDVDRTK-KDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYST 2925

Query: 753  CSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEE 807
             S+     DS QP+  +    EE  V  +L       + +        ++ +      E 
Sbjct: 2926 PSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEG 2985

Query: 808  EEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQV 864
            EE++ P  PR    L + +E EV Q+S D  YST S   E+    Q YS   +SLEEQ +
Sbjct: 2986 EEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL 3045

Query: 865  CMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSC 924
             +A+D+   + DQ ++EDQ    PRLSRELL+   PEVLQDSLDRCYSTPS  LE  DSC
Sbjct: 3046 GLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSC 3105

Query: 925  QPYRSAFYILEQQRVGWALDMDEIEKY-------------------QEVEEDQDPSCPRL 965
            QPY S+FY LE++ VG++LD+ EIEK                    +E EEDQ+P CPRL
Sbjct: 3106 QPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 3165

Query: 966  SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKK 1025
            SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR KK
Sbjct: 3166 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKK 3225

Query: 1026 DQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALE 1085
            DQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALE
Sbjct: 3226 DQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALE 3285

Query: 1086 EKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEP 1145
            EKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ +EP
Sbjct: 3286 EKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDEKEP 3344

Query: 1146 EVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            EVLQDSLDRCYSTPS Y ELPD  Q Y S  YS EEQ++  ALDVD
Sbjct: 3345 EVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 3390



 Score =  568 bits (1463), Expect = e-161
 Identities = 427/1044 (40%), Positives = 540/1044 (51%), Gaps = 110/1044 (10%)

Query: 189  REVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSH 248
            RE+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +   L VDR    
Sbjct: 2585 RELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKD 2644

Query: 249  DECQDAVNILPVPGPTSSATNVSMVVSAGPLSS----EKAEMNILEMNEKLRPQLAEKKQ 304
             E ++       P P  S   + +V       S         + LE  +  +P       
Sbjct: 2645 QEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY----GS 2697

Query: 305  QFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELR 364
             F  L+EK       GF  +        E E   K   R  R+ K+E+   + K+ EE +
Sbjct: 2698 SFYALEEKH-----VGFSLD------VGEIEKKGKGKKRRGRRSKKERRRGR-KEGEEDQ 2745

Query: 365  QYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCR 424
                   S+E    +  E L++  D   S       L    +P +S    L++Q      
Sbjct: 2746 NPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ------ 2799

Query: 425  LAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAIT 481
                   ++    D DE E  Q  E E+  + S PR   E+   +E +V +DSL+ C  T
Sbjct: 2800 -------RVGLAVDMDEIEKYQ--EVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYST 2850

Query: 482  CSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNV 541
             S      D  QP+ +   + EE  +  AL VDR     E ++       P P  S   +
Sbjct: 2851 PSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQG---PPCPRLSRELL 2907

Query: 542  SMVVSAGPLSS----EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQ 597
             +V       S         + LE  +  +P        F  L+EK     L      ++
Sbjct: 2908 EVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY----GSSFYALEEKHVGFSLDVGEIEKK 2963

Query: 598  NKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLRE 657
             K K    +   K   R  ++ +E++     + + EL   K              E L++
Sbjct: 2964 GKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKE------------PEVLQD 3011

Query: 658  GRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQ 717
              D   S       L    +P  S    L+EQ   G  L     +K     D + +ED  
Sbjct: 3012 SLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL-GLALDVDRTKK-----DQEEEED-- 3063

Query: 718  VEVAEKVQKSSAPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 774
                   Q    PR   E+ +  E EV +DSL+ C  T S+     DS QP+  +    E
Sbjct: 3064 -------QGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALE 3116

Query: 775  EDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPR---NLQESEEEE 826
            E  V  +L       + +        ++ +      E EE++ P  PR    L + +E E
Sbjct: 3117 EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPE 3176

Query: 827  VPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEAT 886
            V Q+S D  YST S   E+    Q YS   +SLEEQ + +A+D+   + DQ ++EDQ   
Sbjct: 3177 VLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPP 3236

Query: 887  GPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMD 946
             PRLSRELL+   PEVLQDSLDRCYSTPS  LE  DSCQPY S+FY LE++ VG++LD+ 
Sbjct: 3237 CPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVG 3296

Query: 947  EIEKY-------------------QEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYS 987
            EIEK                    +E EEDQ+P CPRLSRELLDEKEPEVLQDSLDRCYS
Sbjct: 3297 EIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYS 3356

Query: 988  TPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEA 1047
            TPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLE 
Sbjct: 3357 TPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEV 3416

Query: 1048 VEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKR 1107
            VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKR
Sbjct: 3417 VEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKR 3476

Query: 1108 RGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPD 1167
            RGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ + PEVLQDSLDR YSTPS   EL D
Sbjct: 3477 RGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTD 3535

Query: 1168 SFQHYRSVFYSFEEQHISFALDVD 1191
            S Q YRS FY  E+Q +  A+D+D
Sbjct: 3536 SCQPYRSAFYVLEQQRVGLAVDMD 3559



 Score =  554 bits (1428), Expect = e-157
 Identities = 304/483 (62%), Positives = 343/483 (71%), Gaps = 37/483 (7%)

Query: 731  REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVE 790
            RE+   +  EV +DSL+ C  T S      DS QP+R      E+ +V   +        
Sbjct: 2341 RELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVD------- 2393

Query: 791  WEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLA 847
                   + E E   E EE++ P  PR    L + +E EV Q+S D  YST S   E+  
Sbjct: 2394 -------MDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPD 2446

Query: 848  SYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSL 907
              Q YS   +SLEEQ + +A+D+   + DQ ++EDQ    PRLSRELL+   PEVLQDSL
Sbjct: 2447 LGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSL 2506

Query: 908  DRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKY---------------- 951
            DRCYSTPS  LE  DSCQPY S+FY LE++ VG++LD+ EIEK                 
Sbjct: 2507 DRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERR 2566

Query: 952  ---QEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYS 1008
               +E EEDQ+P CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYS
Sbjct: 2567 RGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYS 2626

Query: 1009 LEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCL 1068
            LEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCL
Sbjct: 2627 LEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCL 2686

Query: 1069 EQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQ 1128
            EQPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQ
Sbjct: 2687 EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQ 2745

Query: 1129 NPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFAL 1188
            NPPCPRLS  L++ + PEVLQDSLDRCYSTPS   EL DS Q YRS FY  E+Q +  A+
Sbjct: 2746 NPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAV 2805

Query: 1189 DVD 1191
            D+D
Sbjct: 2806 DMD 2808



 Score =  422 bits (1085), Expect = e-117
 Identities = 377/1179 (31%), Positives = 527/1179 (44%), Gaps = 206/1179 (17%)

Query: 90   EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPD---------EPDKSQ 140
            +E+ +Y+ +   Q+    +L  +L + ++     +   +   TP          +P  S 
Sbjct: 1663 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 1722

Query: 141  GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVP 200
               L+EQ   G  L    V +   + +E+ED+                RE+ +  E +V 
Sbjct: 1723 VYSLEEQYL-GLALD---VDRTKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVL 1770

Query: 201  EDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVV-------------DRESS 247
            +DSL+ C  T S+     DS QP+ +     EE  V  +L V              R S 
Sbjct: 1771 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSK 1830

Query: 248  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSE-------KAEMNILEMNEKLRPQLA 300
             +  +          P     +  ++   GP   +             LE+ +  +P   
Sbjct: 1831 KERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPY-- 1888

Query: 301  EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEEC-EDLIKSMLRNERQFKEEKLAEQLKQ 359
              +  F  L++     Q  G   +     KY+E  ED   S  R  R+  +EK  E L+ 
Sbjct: 1889 --RSAFYVLEQ-----QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQD 1941

Query: 360  AEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQL 419
            + + R Y     S   EL  L                         +P  S    L+EQ 
Sbjct: 1942 SLD-RCYS--TPSGYLELPDL------------------------GQPYSSAVYSLEEQY 1974

Query: 420  AEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECA 479
              G  L    V +   + +E+ED+                RE+ +  E +V +DSL+ C 
Sbjct: 1975 L-GLALD---VDRTKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVLQDSLDRCY 2022

Query: 480  ITCSNSHGPCDSNQPHKNINITFEEDKVNSALVV-------------DRESSHDECQDAV 526
             T S+     DS QP+ +     EE  V  +L V              R S  +  +   
Sbjct: 2023 STPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRK 2082

Query: 527  NILPVPGPTSSATNVSMVVSAGPL-------SSEKAEMNILEMNEKLRPQLAEKKQQFRN 579
                   P     +  ++   GP         S       LE+ +  +P     +  F  
Sbjct: 2083 EGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPY----RSAFYV 2138

Query: 580  LKEKCFVTQLACFLANQQNKYKYEEC-KDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
            L++     Q      +     KY+E  +D   S  R  R+  +EK  E L+ + +     
Sbjct: 2139 LEQ-----QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLD----- 2188

Query: 639  VLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQ 698
               +S      +L +  +    A  SL +    L    +  K   ++ ++Q     RL++
Sbjct: 2189 -RCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSR 2247

Query: 699  QLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHG 758
            +L + + P                                 EV +DSL+ C  T S+   
Sbjct: 2248 ELLEVVEP---------------------------------EVLQDSLDRCYSTPSSCLE 2274

Query: 759  PYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGP 813
              DS QP+  +    EE  V  +L       + +        ++ +      E EE++ P
Sbjct: 2275 QPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNP 2334

Query: 814  VSPRNLQESEEE---EVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDI 870
              PR  +E  +E   EV Q+S D  YST S   E+  S Q Y   F+ LE+Q+V +AVD+
Sbjct: 2335 PCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDM 2394

Query: 871  GGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSA 930
                  Q  +EDQ+ + PRLSRELLDEK PEVLQDSLDRCYSTPSGYLEL D  QPY SA
Sbjct: 2395 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 2454

Query: 931  FYILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPS 990
             Y LE+Q +G ALD+D  +K QE EEDQ P CPRLSRELL+  EPEVLQDSLDRCYSTPS
Sbjct: 2455 VYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPS 2514

Query: 991  GYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEEEE 1031
              LE PD  QPY S+ Y+LEE+++G +LDV  I+K                    +E EE
Sbjct: 2515 SCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 2574

Query: 1032 DQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGF 1091
            DQ PPCPRLSRELL+  EPEVLQDSLDRCYSTPS  LE PD   PY S+ Y+LEE+++G 
Sbjct: 2575 DQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGL 2634

Query: 1092 SLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDS 1151
            +LDV   +K                     +E EEDQ PPCPRLS  L+EV EPEVLQDS
Sbjct: 2635 ALDVDRTKKD--------------------QEEEEDQGPPCPRLSRELLEVVEPEVLQDS 2674

Query: 1152 LDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDV 1190
            LDRCYSTPS   E PDS Q Y S FY+ EE+H+ F+LDV
Sbjct: 2675 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDV 2713



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 86/340 (25%), Positives = 131/340 (38%), Gaps = 41/340 (12%)

Query: 189  REVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSH 248
            RE+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +   L VDR    
Sbjct: 3336 RELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKD 3395

Query: 249  DECQDAVNILPVPGPTSSATNVSMVVSAGPLSS----EKAEMNILEMNEKLRPQLAEKKQ 304
             E ++       P P  S   + +V       S         + LE  +  +P       
Sbjct: 3396 QEEEEDQG---PPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPY----GS 3448

Query: 305  QFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELR 364
             F  L+EK       GF  +        E E   K   R  R+ K+E+   + K+ EE +
Sbjct: 3449 SFYALEEKH-----VGFSLD------VGEIEKKGKGKKRRGRRSKKERRRGR-KEGEEDQ 3496

Query: 365  QYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCR 424
                   S+E    +  E L++  D S S       L    +P +S    L++Q      
Sbjct: 3497 NPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQ------ 3550

Query: 425  LAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAIT 481
                   ++    D DE E  Q  E E+  + S PR   E+   +E +V +DSL+ C  T
Sbjct: 3551 -------RVGLAVDMDEIEKYQ--EVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYST 3601

Query: 482  CSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDE 521
             S      D  QP+ +   + EE  +  AL VDR     E
Sbjct: 3602 PSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQE 3641



 Score = 38.1 bits (87), Expect = 0.051
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 3/85 (3%)

Query: 169  DEDEDVQVEEAEKVLESSAPR---EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK 225
            D DE  + +E E+  + S PR   E+   +E +V +DSL+ C  T S      D  QP+ 
Sbjct: 3557 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 3616

Query: 226  NINITFEEDKVNSTLVVDRESSHDE 250
            +   + EE  +   L VDR     E
Sbjct: 3617 SAVYSLEEQYLGLALDVDRTKKDQE 3641



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 3/80 (3%)

Query: 448  EEAEKVLESSAPREVQKAEESKVPE---DSLEECAITCSNSHGPCDSNQPHKNINITFEE 504
            +E E+      PR  ++  + K PE   DSL+ C  T S      DS QP+++     E+
Sbjct: 1594 KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQ 1653

Query: 505  DKVNSALVVDRESSHDECQD 524
             +V  A+ +D    + E ++
Sbjct: 1654 QRVGLAVDMDEIEKYQEVEE 1673



 Score = 32.0 bits (71), Expect = 3.7
 Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 3/80 (3%)

Query: 177  EEAEKVLESSAPREVQKAEESKVPE---DSLEECAITCSNSHGPCDSNQPHKNINITFEE 233
            +E E+      PR  ++  + K PE   DSL+ C  T S      DS QP+++     E+
Sbjct: 1594 KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQ 1653

Query: 234  DKVNSTLVVDRESSHDECQD 253
             +V   + +D    + E ++
Sbjct: 1654 QRVGLAVDMDEIEKYQEVEE 1673



 Score = 32.0 bits (71), Expect = 3.7
 Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 3/72 (4%)

Query: 448  EEAEKVLESSAPREVQKAEESKVPE---DSLEECAITCSNSHGPCDSNQPHKNINITFEE 504
            +E E+      PR  ++  + K PE   DSL+ C  T S      DS QP+++     E+
Sbjct: 3734 KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQ 3793

Query: 505  DKVNSALVVDRE 516
             +V  A+ +D E
Sbjct: 3794 QRVGLAVDMDGE 3805



 Score = 31.6 bits (70), Expect = 4.8
 Identities = 37/162 (22%), Positives = 66/162 (40%), Gaps = 21/162 (12%)

Query: 90   EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPD---------EPDKSQ 140
            +E+ +Y+ +   Q+    +L  +L + ++     +   +   TP          +P  S 
Sbjct: 2808 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 2867

Query: 141  GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVP 200
               L+EQ   G  L    V +   + +E+ED+                RE+ +  E +V 
Sbjct: 2868 VYSLEEQYL-GLALD---VDRTKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVL 2915

Query: 201  EDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVV 242
            +DSL+ C  T S+     DS QP+ +     EE  V  +L V
Sbjct: 2916 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDV 2957



 Score = 31.6 bits (70), Expect = 4.8
 Identities = 37/162 (22%), Positives = 66/162 (40%), Gaps = 21/162 (12%)

Query: 90   EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPD---------EPDKSQ 140
            +E+ +Y+ +   Q+    +L  +L + ++     +   +   TP          +P  S 
Sbjct: 3559 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 3618

Query: 141  GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVP 200
               L+EQ   G  L    V +   + +E+ED+                RE+ +  E +V 
Sbjct: 3619 VYSLEEQYL-GLALD---VDRTKKDQEEEEDQGPPCPRLS--------RELLEVVEPEVL 3666

Query: 201  EDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVV 242
            +DSL+ C  T S+     DS QP+ +     EE  V  +L V
Sbjct: 3667 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDV 3708


>gi|7657017 hypothetical protein LOC25832 [Homo sapiens]
          Length = 921

 Score = 1078 bits (2787), Expect = 0.0
 Identities = 536/580 (92%), Positives = 550/580 (94%), Gaps = 1/580 (0%)

Query: 612  VLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQA 671
            +LRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDASRSLN+HLQA
Sbjct: 1    MLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQA 60

Query: 672  LLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPR 731
            LLTPDEPDKSQGQDLQEQLAEGCRLAQ L QKLSPENDND DEDVQVEVAEKVQKSSAPR
Sbjct: 61   LLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPR 120

Query: 732  EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEW 791
            EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEW
Sbjct: 121  EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEW 180

Query: 792  EDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQS 851
            EDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASY+S
Sbjct: 181  EDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYKS 240

Query: 852  YSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCY 911
            YS TFHSLEEQQVCMAVDIG HRWDQVKKED EATGPRLSRELLDEKGPEVLQDSLDRCY
Sbjct: 241  YSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDHEATGPRLSRELLDEKGPEVLQDSLDRCY 300

Query: 912  STPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLD 971
            STPSG LELTDSCQPYRSAFY+LEQQRVG A++MDEIEKYQEVEEDQDPSCPRLSRELLD
Sbjct: 301  STPSGCLELTDSCQPYRSAFYVLEQQRVGLAVNMDEIEKYQEVEEDQDPSCPRLSRELLD 360

Query: 972  EKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEE 1031
            EKEPEVLQDSL RCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDRIKKDQEEEE
Sbjct: 361  EKEPEVLQDSLGRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEE 420

Query: 1032 DQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGF 1091
            DQGPPCPRLSRELLE VEPEVLQDSLDRCYSTPSSCLEQPDSC PYGSSFYALEEKHVGF
Sbjct: 421  DQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGF 480

Query: 1092 SLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDS 1151
            SLDVGEIEKKGKGKKRRGRRS KK RRRGRKEGEEDQNPPCPRLS  L++ + PEVLQDS
Sbjct: 481  SLDVGEIEKKGKGKKRRGRRS-KKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDS 539

Query: 1152 LDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVD 1191
            LDRCYSTPS   EL DS Q YRS FY  E+Q +  A+D+D
Sbjct: 540  LDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMD 579



 Score =  972 bits (2513), Expect = 0.0
 Identities = 564/938 (60%), Positives = 638/938 (68%), Gaps = 81/938 (8%)

Query: 341  MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQA 400
            MLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDASRSLN+HLQA
Sbjct: 1    MLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQA 60

Query: 401  LLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR 460
            LLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE AEKV +SSAPR
Sbjct: 61   LLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPR 120

Query: 461  EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHD 520
            E+QKAEE +VPEDSLEECAITCSNSHGP DSNQPH+   ITFEEDKV+S L+    SSH 
Sbjct: 121  EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLI--GSSSHV 178

Query: 521  ECQDAVNILPV----------PGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQL 570
            E +DAV+I+P            GP S            P  S     + L +  ++    
Sbjct: 179  EWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASY 238

Query: 571  AEKKQQFRNLKEK--CFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQL 628
                  F +L+E+  C    +     +Q  K  +E          R  R+  +EK  E L
Sbjct: 239  KSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDHEATGP------RLSRELLDEKGPEVL 292

Query: 629  KQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL-LTPDEPDKSQGQDLQ 687
            + + +        +S      +L +  +  R A   L Q    L +  DE +K Q  +++
Sbjct: 293  QDSLDR------CYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVNMDEIEKYQ--EVE 344

Query: 688  EQLAEGC-RLAQQLFQKLSPENDNDH---------------------------------- 712
            E     C RL+++L  +  PE   D                                   
Sbjct: 345  EDQDPSCPRLSRELLDEKEPEVLQDSLGRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLG 404

Query: 713  ---DEDVQVEVAEKVQKSSAP-----REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQ 764
               D D   +  E+ +    P     RE+ +  E EV +DSL+ C  T S+     DS Q
Sbjct: 405  LALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQ 464

Query: 765  PHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPRNL 819
            P+  +    EE  V  +L       + +        ++ +      E EE++ P  PR  
Sbjct: 465  PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLS 524

Query: 820  QESEEE---EVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWD 876
            +E  +E   EV Q+S D  YST S   E+  S Q Y   F+ LE+Q+V +AVD+      
Sbjct: 525  RELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDEIEKY 584

Query: 877  QVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQ 936
            Q  +EDQ+ + PRLS ELLDEK PEVLQ+SLDRCYSTPSG LELTDSCQPYRSAFYILEQ
Sbjct: 585  QEVEEDQDPSCPRLSGELLDEKEPEVLQESLDRCYSTPSGCLELTDSCQPYRSAFYILEQ 644

Query: 937  QRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 996
            QRVG A+DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSL RCYSTPSGYLELP
Sbjct: 645  QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLGRCYSTPSGYLELP 704

Query: 997  DLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDS 1056
            DLGQPY SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLE VEPEVLQDS
Sbjct: 705  DLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 764

Query: 1057 LDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKR 1116
            LDRCYSTPSSCLEQPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK 
Sbjct: 765  LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKE 823

Query: 1117 RRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVF 1176
            RRRGRKEGEEDQNPPCPRL+ MLMEVEEPEVLQDSLD CYSTPSMYFELPDSFQHYRSVF
Sbjct: 824  RRRGRKEGEEDQNPPCPRLNSMLMEVEEPEVLQDSLDICYSTPSMYFELPDSFQHYRSVF 883

Query: 1177 YSFEEQHISFALDVDNRFLTLMGTSLHLVFQMGVIFPQ 1214
            YSFEE+HISFAL VDNRF TL  TSLHLVFQMGVIFPQ
Sbjct: 884  YSFEEEHISFALYVDNRFFTLTVTSLHLVFQMGVIFPQ 921



 Score =  536 bits (1382), Expect = e-152
 Identities = 395/1003 (39%), Positives = 510/1003 (50%), Gaps = 156/1003 (15%)

Query: 70   MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQA 129
            MLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDASRSLN+HLQA
Sbjct: 1    MLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQA 60

Query: 130  LLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR 189
            LLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE AEKV +SSAPR
Sbjct: 61   LLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPR 120

Query: 190  EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHD 249
            E+QKAEE +VPEDSLEECAITCSNSHGP DSNQPH+   ITFEEDKV+STL+    SSH 
Sbjct: 121  EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLI--GSSSHV 178

Query: 250  ECQDAVNILP----------VPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQL 299
            E +DAV+I+P            GP S            P  S     + L +  ++    
Sbjct: 179  EWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASY 238

Query: 300  AEKKQQFRNLKEK--CFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQL 357
                  F +L+E+  C    +     +Q  K      ED   +  R  R+  +EK  E L
Sbjct: 239  KSYSSTFHSLEEQQVCMAVDIGRHRWDQVKK------EDHEATGPRLSRELLDEKGPEVL 292

Query: 358  KQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL-LTPDEPDKSQGQDLQ 416
            + + +        +S      +L +  +  R A   L Q    L +  DE +K Q     
Sbjct: 293  QDSLD------RCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVNMDEIEKYQ----- 341

Query: 417  EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLE 476
                               E +ED+D                 RE+   +E +V +DSL 
Sbjct: 342  -------------------EVEEDQDPSC----------PRLSRELLDEKEPEVLQDSLG 372

Query: 477  ECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTS 536
             C  T S      D  QP+ +   + EE  +  AL VDR     E ++            
Sbjct: 373  RCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEE------------ 420

Query: 537  SATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQ 596
                       GP     +     E+ E + P++       ++  ++C+ T  +C     
Sbjct: 421  ---------DQGPPCPRLSR----ELLEVVEPEV------LQDSLDRCYSTPSSCL---- 457

Query: 597  QNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLR 656
                   E  D  +    +    +E+ +   L   E  ++ K       R   + R   +
Sbjct: 458  -------EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRK 510

Query: 657  EGRDASRSLNQHLQALLTPDEPDKSQGQDLQE----------QLAEGCRLAQQLFQKLSP 706
            EG +        L   L  DE      QD  +          +L + C+  +  F  L  
Sbjct: 511  EGEEDQNPPCPRLSRELL-DEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQ 569

Query: 707  ENDN---DHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVPEDSLEECAITCSNSHGPY 760
            +      D DE  + +  E+ Q  S PR   E+   +E EV ++SL+ C  T S      
Sbjct: 570  QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSGELLDEKEPEVLQESLDRCYSTPSGCLELT 629

Query: 761  DSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSP---R 817
            DS QP+R      E+ +V   +               + E E   E EE++ P  P   R
Sbjct: 630  DSCQPYRSAFYILEQQRVGLAV--------------DMDEIEKYQEVEEDQDPSCPRLSR 675

Query: 818  NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQ 877
             L + +E EV Q+S    YST S   E+    Q YS   +SLEEQ + +A+D+   + DQ
Sbjct: 676  ELLDEKEPEVLQDSLGRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQ 735

Query: 878  VKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQ 937
             ++EDQ    PRLSRELL+   PEVLQDSLDRCYSTPS  LE  DSCQPY S+FY LE++
Sbjct: 736  EEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEK 795

Query: 938  RVGWALDMDEIEK-------------------YQEVEEDQDPSCPRLSRELLDEKEPEVL 978
             VG++LD+ EIEK                    +E EEDQ+P CPRL+  L++ +EPEVL
Sbjct: 796  HVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNSMLMEVEEPEVL 855

Query: 979  QDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 1021
            QDSLD CYSTPS Y ELPD  Q YRS  YS EE+++  AL VD
Sbjct: 856  QDSLDICYSTPSMYFELPDSFQHYRSVFYSFEEEHISFALYVD 898


>gi|14149997 neuroblastoma breakpoint family, member 3 [Homo sapiens]
          Length = 633

 Score =  836 bits (2159), Expect = 0.0
 Identities = 433/577 (75%), Positives = 479/577 (83%), Gaps = 4/577 (0%)

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 578
            H E +D      VPGPTSSATNVSMVVSAGP S EKAEMNILE+N+K RPQLAE KQQFR
Sbjct: 37   HQELRDPT----VPGPTSSATNVSMVVSAGPWSGEKAEMNILEINKKSRPQLAENKQQFR 92

Query: 579  NLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYK 638
            NLK+KC VTQ+A FLAN+QN Y YE+CKDLIKS+LR+ER   EEKLAE+L QAEELRQYK
Sbjct: 93   NLKQKCLVTQVAYFLANRQNNYDYEDCKDLIKSMLRDERLLTEEKLAEELGQAEELRQYK 152

Query: 639  VLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQ 698
            VLVHSQERELTQLREKL+EGRDASRSLNQHLQALLTPDEPD SQG+DL+EQLAEGCRLAQ
Sbjct: 153  VLVHSQERELTQLREKLQEGRDASRSLNQHLQALLTPDEPDNSQGRDLREQLAEGCRLAQ 212

Query: 699  QLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHG 758
             L QKLSPEND+D DEDV+VE AEKVQ+  APRE+QKAEEKEVPEDSLEECAITCSNSH 
Sbjct: 213  HLVQKLSPENDDDEDEDVKVEEAEKVQELYAPREVQKAEEKEVPEDSLEECAITCSNSHH 272

Query: 759  PYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRN 818
            P +SNQP+  T+ITFEED+VDSTLI SSSH EW DAV IIPENESD E+EEEKGPVSPRN
Sbjct: 273  PCESNQPYGNTRITFEEDQVDSTLIDSSSHDEWLDAVCIIPENESDHEQEEEKGPVSPRN 332

Query: 819  LQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQV 878
            LQESEEEE PQESWDEG  TLSIPP+M ASYQS   TFHS+EEQQV +A+DIG H  DQV
Sbjct: 333  LQESEEEEAPQESWDEGDWTLSIPPDMSASYQSDRSTFHSVEEQQVGLALDIGRHWCDQV 392

Query: 879  KKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQR 938
            KKEDQEAT PRLSRELLDEK PEVLQDSLDR YSTP  YLEL D CQPYRS FY L++Q 
Sbjct: 393  KKEDQEATSPRLSRELLDEKEPEVLQDSLDRFYSTPFEYLELPDLCQPYRSDFYSLQEQH 452

Query: 939  VGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDL 998
            +G ALD+D ++K QE EEDQ P CPRLSREL +  EPE LQDSLDR YSTP  Y ELPD 
Sbjct: 453  LGLALDLDRMKKDQEEEEDQGPPCPRLSRELPEVVEPEDLQDSLDRWYSTPFSYPELPDS 512

Query: 999  GQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLD 1058
             QPY S  YSLEE+++G +LDVD I+K QE EEDQ PPCPRL+  L+EA EPEVLQDSLD
Sbjct: 513  CQPYGSCFYSLEEEHVGFSLDVDEIEKYQEGEEDQKPPCPRLNEVLMEAEEPEVLQDSLD 572

Query: 1059 RCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDV 1095
            RCYST S+  +   S   Y S+FY+ EE+ V  +LDV
Sbjct: 573  RCYSTTSTYFQLHASFQQYRSAFYSFEEQDVSLALDV 609



 Score =  454 bits (1168), Expect = e-127
 Identities = 290/586 (49%), Positives = 358/586 (61%), Gaps = 66/586 (11%)

Query: 248 HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 307
           H E +D      VPGPTSSATNVSMVVSAGP S EKAEMNILE+N+K RPQLAE KQQFR
Sbjct: 37  HQELRDPT----VPGPTSSATNVSMVVSAGPWSGEKAEMNILEINKKSRPQLAENKQQFR 92

Query: 308 NLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYK 367
           NLK+KC VTQ+A FLAN+QN Y YE+C+DLIKSMLR+ER   EEKLAE+L QAEELRQYK
Sbjct: 93  NLKQKCLVTQVAYFLANRQNNYDYEDCKDLIKSMLRDERLLTEEKLAEELGQAEELRQYK 152

Query: 368 VLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQ 427
           VLVHSQERELTQLREKL+EGRDASRSLNQHLQALLTPDEPD SQG+DL+EQLAEGCRLAQ
Sbjct: 153 VLVHSQERELTQLREKLQEGRDASRSLNQHLQALLTPDEPDNSQGRDLREQLAEGCRLAQ 212

Query: 428 HLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHG 487
           HLVQKLSPEND+DEDEDV+VEEAEKV E  APREVQKAEE +VPEDSLEECAITCSNSH 
Sbjct: 213 HLVQKLSPENDDDEDEDVKVEEAEKVQELYAPREVQKAEEKEVPEDSLEECAITCSNSHH 272

Query: 488 PCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSA 547
           PC+SNQP+ N  ITFEED+V+S L+    SSHDE  DAV I+P      + ++       
Sbjct: 273 PCESNQPYGNTRITFEEDQVDSTLI--DSSSHDEWLDAVCIIP-----ENESDHEQEEEK 325

Query: 548 GPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNL----KEKCFVTQLACF--LANQQNKYK 601
           GP+S      N+ E  E+  PQ +  +  +           + +  + F  +  QQ    
Sbjct: 326 GPVSPR----NLQESEEEEAPQESWDEGDWTLSIPPDMSASYQSDRSTFHSVEEQQVGLA 381

Query: 602 YEECKDLIKSVLRNERQFKEEKLAEQL---KQAEELRQYKVLVHSQERELTQLREKLREG 658
            +  +     V + +++    +L+ +L   K+ E L+      +S   E  +L +  +  
Sbjct: 382 LDIGRHWCDQVKKEDQEATSPRLSRELLDEKEPEVLQDSLDRFYSTPFEYLELPDLCQPY 441

Query: 659 RDASRSL-NQHLQALLTPD------EPDKSQG----------------QDLQE------- 688
           R    SL  QHL   L  D      E ++ QG                +DLQ+       
Sbjct: 442 RSDFYSLQEQHLGLALDLDRMKKDQEEEEDQGPPCPRLSRELPEVVEPEDLQDSLDRWYS 501

Query: 689 ------QLAEGCRLAQQLFQKLSPEN---DNDHDEDVQVEVAEKVQKSSAPR---EMQKA 736
                 +L + C+     F  L  E+     D DE  + +  E+ QK   PR    + +A
Sbjct: 502 TPFSYPELPDSCQPYGSCFYSLEEEHVGFSLDVDEIEKYQEGEEDQKPPCPRLNEVLMEA 561

Query: 737 EEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 782
           EE EV +DSL+ C  T S     + S Q +R    +FEE  V   L
Sbjct: 562 EEPEVLQDSLDRCYSTTSTYFQLHASFQQYRSAFYSFEEQDVSLAL 607



 Score =  434 bits (1117), Expect = e-121
 Identities = 280/568 (49%), Positives = 346/568 (60%), Gaps = 68/568 (11%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
           MVVSAGPWS EKAE NILEIN+K RPQLAENKQQFRNLK+KC VTQ+A FLANRQ  Y Y
Sbjct: 57  MVVSAGPWSGEKAEMNILEINKKSRPQLAENKQQFRNLKQKCLVTQVAYFLANRQNNYDY 116

Query: 61  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
           E+CKDLIK MLR+ER   EEKLAE+L QAEELRQYKVLVHSQERELTQLREKL+EGRDAS
Sbjct: 117 EDCKDLIKSMLRDERLLTEEKLAEELGQAEELRQYKVLVHSQERELTQLREKLQEGRDAS 176

Query: 121 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
           RSLNQHLQALLTPDEPD SQG+DL+EQLAEGCRLAQHLVQKLSPEND+DEDEDV+VEEAE
Sbjct: 177 RSLNQHLQALLTPDEPDNSQGRDLREQLAEGCRLAQHLVQKLSPENDDDEDEDVKVEEAE 236

Query: 181 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
           KV E  APREVQKAEE +VPEDSLEECAITCSNSH PC+SNQP+ N  ITFEED+V+STL
Sbjct: 237 KVQELYAPREVQKAEEKEVPEDSLEECAITCSNSHHPCESNQPYGNTRITFEEDQVDSTL 296

Query: 241 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLS------SEKAEMNILEMNE- 293
           +    SSHDE  DAV I+P      + ++       GP+S      SE+ E      +E 
Sbjct: 297 I--DSSSHDEWLDAVCIIP-----ENESDHEQEEEKGPVSPRNLQESEEEEAPQESWDEG 349

Query: 294 ----KLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFK 349
                + P ++   Q  R+        Q+   L   ++     + ED   +  R  R+  
Sbjct: 350 DWTLSIPPDMSASYQSDRSTFHSVEEQQVGLALDIGRHWCDQVKKEDQEATSPRLSRELL 409

Query: 350 EEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSL-NQHLQALLTPDEPD 408
           +EK  E L+ + +        +S   E  +L +  +  R    SL  QHL   L  D   
Sbjct: 410 DEKEPEVLQDSLD------RFYSTPFEYLELPDLCQPYRSDFYSLQEQHLGLALDLDRMK 463

Query: 409 KSQGQDLQEQLAEGCRLAQHLVQKLSPENDED---------------------------- 440
           K Q ++ ++Q     RL++ L + + PE+ +D                            
Sbjct: 464 KDQEEE-EDQGPPCPRLSRELPEVVEPEDLQDSLDRWYSTPFSYPELPDSCQPYGSCFYS 522

Query: 441 -EDEDV----QVEEAEKVLESSAPRE---------VQKAEESKVPEDSLEECAITCSNSH 486
            E+E V     V+E EK  E    ++         + +AEE +V +DSL+ C  T S   
Sbjct: 523 LEEEHVGFSLDVDEIEKYQEGEEDQKPPCPRLNEVLMEAEEPEVLQDSLDRCYSTTSTYF 582

Query: 487 GPCDSNQPHKNINITFEEDKVNSALVVD 514
               S Q +++   +FEE  V+ AL VD
Sbjct: 583 QLHASFQQYRSAFYSFEEQDVSLALDVD 610


>gi|239741297 PREDICTED: neuroblastoma breakpoint family, member 9
           [Homo sapiens]
          Length = 299

 Score =  526 bits (1356), Expect = e-149
 Identities = 267/287 (93%), Positives = 274/287 (95%)

Query: 543 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKY 602
           MVVSAGPLSSEKAEMNILE+NEKLRPQLAEKKQQFR+LKEKCFVTQLA FLA QQNKYKY
Sbjct: 1   MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRSLKEKCFVTQLAGFLAKQQNKYKY 60

Query: 603 EECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 662
           EECKDLIKS+LRNE QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 61  EECKDLIKSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120

Query: 663 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAE 722
           RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQ L QKLSPENDND DEDVQVEVAE
Sbjct: 121 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 180

Query: 723 KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 782
           KVQKSS+PREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL
Sbjct: 181 KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 240

Query: 783 IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQ 829
           IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR    S E+  P+
Sbjct: 241 IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRTSVGSSEKGGPR 287



 Score =  449 bits (1156), Expect = e-126
 Identities = 234/288 (81%), Positives = 250/288 (86%), Gaps = 12/288 (4%)

Query: 272 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKY 331
           MVVSAGPLSSEKAEMNILE+NEKLRPQLAEKKQQFR+LKEKCFVTQLAGFLA QQNKYKY
Sbjct: 1   MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRSLKEKCFVTQLAGFLAKQQNKYKY 60

Query: 332 EECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 391
           EEC+DLIKSMLRNE QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 61  EECKDLIKSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120

Query: 392 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 451
           RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE AE
Sbjct: 121 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 180

Query: 452 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSAL 511
           KV +SS+PRE+QKAEE +VPEDSLEECAITCSNSHGP DSNQPH+   ITFEEDKV+S L
Sbjct: 181 KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 240

Query: 512 VVDRESSHDECQDAVNILP----------VPGPTSSATNVSMVVSAGP 549
           +    SSH E +DAV+I+P            GP S  T+V      GP
Sbjct: 241 I--GSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRTSVGSSEKGGP 286



 Score =  441 bits (1135), Expect = e-123
 Identities = 231/288 (80%), Positives = 246/288 (85%), Gaps = 12/288 (4%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
           MVVSAGP SSEKAE NILEINEKLRPQLAE KQQFR+LKEKCFVTQLAGFLA +Q KYKY
Sbjct: 1   MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRSLKEKCFVTQLAGFLAKQQNKYKY 60

Query: 61  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
           EECKDLIK MLRNE QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 61  EECKDLIKSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120

Query: 121 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
           RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE AE
Sbjct: 121 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 180

Query: 181 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
           KV +SS+PRE+QKAEE +VPEDSLEECAITCSNSHGP DSNQPH+   ITFEEDKV+STL
Sbjct: 181 KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 240

Query: 241 VVDRESSHDECQDAVNILP----------VPGPTSSATNVSMVVSAGP 278
           +    SSH E +DAV+I+P            GP S  T+V      GP
Sbjct: 241 I--GSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRTSVGSSEKGGP 286



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 35/112 (31%), Positives = 49/112 (43%), Gaps = 17/112 (15%)

Query: 944  DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYR 1003
            D DE  + +  E+ Q  S PR   E+   +E EV +DSL+ C  T S      D  QP+R
Sbjct: 169  DDDEDVQVEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHR 225

Query: 1004 SAVYSLEEQYLGLALD--------------VDRIKKDQEEEEDQGPPCPRLS 1041
                + EE  +   L               +   + D EEEE++GP  PR S
Sbjct: 226  KTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRTS 277



 Score = 34.7 bits (78), Expect = 0.57
 Identities = 30/104 (28%), Positives = 46/104 (44%), Gaps = 17/104 (16%)

Query: 877 QVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQ 936
           +V ++ Q+++ PR   E+   +  EV +DSL+ C  T S      DS QP+R      E+
Sbjct: 177 EVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEE 233

Query: 937 QRVGWAL--------------DMDEIEKYQEVEEDQDPSCPRLS 966
            +V   L               + E E   E EE++ P  PR S
Sbjct: 234 DKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRTS 277



 Score = 33.9 bits (76), Expect = 0.97
 Identities = 29/91 (31%), Positives = 43/91 (47%), Gaps = 13/91 (14%)

Query: 1125 EEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHI 1184
            E+ Q    PR    + + EE EV +DSL+ C  T S      DS Q +R    +FEE  +
Sbjct: 180  EKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKV 236

Query: 1185 SFALDVDNRFLTLMGTSLHLVFQMGV-IFPQ 1214
                       TL+G+S H+ ++  V I P+
Sbjct: 237  D---------STLIGSSSHVEWEDAVHIIPE 258



 Score = 31.6 bits (70), Expect = 4.8
 Identities = 39/163 (23%), Positives = 68/163 (41%), Gaps = 27/163 (16%)

Query: 946  DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSA 1005
            +E+ +Y+ +   Q+    +L  +L + ++     +   +   TP          +P +S 
Sbjct: 90   EELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPD---------EPDKSQ 140

Query: 1006 VYSLEEQYL-GLALDVDRIKK-----DQEEEED---------QGPPCPRLSRELLEAVEP 1050
               L+EQ   G  L    ++K     D +++ED         Q    PR   E+ +A E 
Sbjct: 141  GQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPR---EMQKAEEK 197

Query: 1051 EVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSL 1093
            EV +DSL+ C  T S+     DS  P+  +    EE  V  +L
Sbjct: 198  EVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 240


>gi|221136844 neuroblastoma breakpoint family, member 6 isoform 1
            [Homo sapiens]
          Length = 667

 Score =  476 bits (1224), Expect = e-134
 Identities = 282/504 (55%), Positives = 344/504 (68%), Gaps = 28/504 (5%)

Query: 543  MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACF-LANQQNKYK 601
            MVVSA PLSSE+AEMNILE+N++LR QLAE  QQFR+LKEK  +TQ   + LANQ  KYK
Sbjct: 1    MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYK 60

Query: 602  YEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 661
             EE KD+I SVLR+E Q   EKLAE+L+QAEELRQYK LVHSQ +ELTQLREKLREGRDA
Sbjct: 61   CEEYKDIIDSVLRDELQ-SMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDA 119

Query: 662  SRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDV--QVE 719
            SR LN+HL+ LLTPD+PDKSQGQDL+EQLAEG RLA+ L  KLSPEND D DED   + E
Sbjct: 120  SRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDE 179

Query: 720  VAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVD 779
              EKVQ+S APRE+QK EEKEVP+DSLEECA+TCSNSH P +SNQPHR TKITF+E +VD
Sbjct: 180  EVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVD 239

Query: 780  STLIGSSSHV--EWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQES---WDE 834
            S L+  S H   E E+A++I PEN++D EEEE K PV PRN Q  E  E+          
Sbjct: 240  SALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPVPPRNRQSLEPGELTNLRDFLISP 299

Query: 835  GYSTLSIP--PEMLASYQSYSGTFHSLEEQQVCMAVDI----GGHRWDQV------KKED 882
              S ++ P   +   SY+    +F +L+EQ+VC A D+       +WD+       K+ D
Sbjct: 300  VVSHVANPGHHDKSNSYRHREVSFLALDEQKVCSAQDVARDYSNPKWDETSLGFLEKQSD 359

Query: 883  ------QEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQ 936
                  QE   PRLSR  L     E+ Q+SLD C  TPS   +LT S  PY S  Y  E 
Sbjct: 360  LEEVKGQETVAPRLSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFED 419

Query: 937  QRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 996
            ++V  AL +D+I+K QE  EDQ P CPRLS+EL + KE EV +DS++  Y TPS + ++ 
Sbjct: 420  KQVSLAL-VDKIKKDQEEIEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVS 478

Query: 997  DLGQPYRSAVYSLEEQYLGLALDV 1020
            D  QPY S + SLE+Q    ALDV
Sbjct: 479  DCHQPYSSTLSSLEDQLACSALDV 502



 Score =  369 bits (946), Expect = e-101
 Identities = 238/539 (44%), Positives = 316/539 (58%), Gaps = 67/539 (12%)

Query: 272 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGF-LANQQNKYK 330
           MVVSA PLSSE+AEMNILE+N++LR QLAE  QQFR+LKEK  +TQ   + LANQ  KYK
Sbjct: 1   MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYK 60

Query: 331 YEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 390
            EE +D+I S+LR+E Q   EKLAE+L+QAEELRQYK LVHSQ +ELTQLREKLREGRDA
Sbjct: 61  CEEYKDIIDSVLRDELQ-SMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDA 119

Query: 391 SRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDV--QVE 448
           SR LN+HL+ LLTPD+PDKSQGQDL+EQLAEG RLA+HLV KLSPENDEDEDED   + E
Sbjct: 120 SRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDE 179

Query: 449 EAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVN 508
           E EKV ES APREVQK EE +VP+DSLEECA+TCSNSH P +SNQPH++  ITF+E +V+
Sbjct: 180 EVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVD 239

Query: 509 SALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMN-EKLR 567
           SALVV+ E  HDE ++A+NI P               +      E+ +  +   N + L 
Sbjct: 240 SALVVESEHPHDEEEEALNIPP--------------ENQNDHEEEEGKAPVPPRNRQSLE 285

Query: 568 PQLAEKKQQFRNLKEKCFVTQLACFLAN-----QQNKYKYEECKDLIKSVLRNERQFKEE 622
           P       +  NL++   ++ +   +AN     + N Y++ E   L            E+
Sbjct: 286 P------GELTNLRD-FLISPVVSHVANPGHHDKSNSYRHREVSFL---------ALDEQ 329

Query: 623 KLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQ 682
           K+      A +    K      E  L  L ++     D      Q   A      P +  
Sbjct: 330 KVCSAQDVARDYSNPK----WDETSLGFLEKQ----SDLEEVKGQETVAPRLSRGPLRVD 381

Query: 683 GQDLQEQLAEGCRLAQQLFQKLSPEND-------NDHDEDVQVEVAEKVQKSS------- 728
             ++ ++  +GC L   +   L+P          +  D+ V + + +K++K         
Sbjct: 382 KHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSLALVDKIKKDQEEIEDQS 441

Query: 729 --APR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 782
              PR   E+ + +E+EVPEDS+ E  +T S  H   D +QP+  T  + E+    S L
Sbjct: 442 PPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQPYSSTLSSLEDQLACSAL 500



 Score =  362 bits (928), Expect = 2e-99
 Identities = 236/527 (44%), Positives = 310/527 (58%), Gaps = 39/527 (7%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGF-LANRQKKYK 59
           MVVSA P SSE+AE NILEIN++LR QLAE+ QQFR+LKEK  +TQ   + LAN+ KKYK
Sbjct: 1   MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYK 60

Query: 60  YEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 119
            EE KD+I  +LR+E Q   EKLAE+L+QAEELRQYK LVHSQ +ELTQLREKLREGRDA
Sbjct: 61  CEEYKDIIDSVLRDELQ-SMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDA 119

Query: 120 SRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDV--QVE 177
           SR LN+HL+ LLTPD+PDKSQGQDL+EQLAEG RLA+HLV KLSPENDEDEDED   + E
Sbjct: 120 SRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDE 179

Query: 178 EAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVN 237
           E EKV ES APREVQK EE +VP+DSLEECA+TCSNSH P +SNQPH++  ITF+E +V+
Sbjct: 180 EVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVD 239

Query: 238 STLVVDRESSHDECQDAVNILPV-PGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLR 296
           S LVV+ E  HDE ++A+NI P            + V      S E  E+  L  +  + 
Sbjct: 240 SALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPVPPRNRQSLEPGELTNLR-DFLIS 298

Query: 297 PQLAEKKQQFRNLKEKCFVTQLAGFLANQQNK----------YKYEECEDLIKSMLRNER 346
           P ++       + K   +  +   FLA  + K          Y   + ++     L  + 
Sbjct: 299 PVVSHVANPGHHDKSNSYRHREVSFLALDEQKVCSAQDVARDYSNPKWDETSLGFLEKQS 358

Query: 347 QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDE 406
             +E K  E +  A  L +  + V   E     + ++  +G   + S+   L     P  
Sbjct: 359 DLEEVKGQETV--APRLSRGPLRVDKHE-----IPQESLDGCCLTPSILPDLTPSYHPYW 411

Query: 407 PDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAE 466
                 +D Q  LA        LV K+  + +E ED+                +E+ + +
Sbjct: 412 STLYSFEDKQVSLA--------LVDKIKKDQEEIEDQSPPCPRLS--------QELPEVK 455

Query: 467 ESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVV 513
           E +VPEDS+ E  +T S  H   D +QP+ +   + E+    SAL V
Sbjct: 456 EQEVPEDSVNEVYLTPSVHHDVSDCHQPYSSTLSSLEDQLACSALDV 502



 Score =  119 bits (297), Expect = 2e-26
 Identities = 113/353 (32%), Positives = 158/353 (44%), Gaps = 66/353 (18%)

Query: 876  DQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILE 935
            D+  ++ QE+  PR   E+   +  EV QDSL+ C  T S     ++S QP+RS     +
Sbjct: 178  DEEVEKVQESPAPR---EVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFK 234

Query: 936  QQRVGWALDMD----------------EIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQ 979
            +  V  AL ++                E +   E EE + P  PR  + L    EP  L 
Sbjct: 235  EHEVDSALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPVPPRNRQSL----EPGELT 290

Query: 980  DSLDRCYSTPSGYLELP---DLGQPYRSAVYS---LEEQYLGLALDVDRI---------- 1023
            +  D   S    ++  P   D    YR    S   L+EQ +  A DV R           
Sbjct: 291  NLRDFLISPVVSHVANPGHHDKSNSYRHREVSFLALDEQKVCSAQDVARDYSNPKWDETS 350

Query: 1024 ------KKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPY 1077
                  + D EE + Q    PRLSR  L   + E+ Q+SLD C  TPS   +   S  PY
Sbjct: 351  LGFLEKQSDLEEVKGQETVAPRLSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPY 410

Query: 1078 GSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSG 1137
             S+ Y+ E+K V  +L V +I+K                     +E  EDQ+PPCPRLS 
Sbjct: 411  WSTLYSFEDKQVSLAL-VDKIKKD--------------------QEEIEDQSPPCPRLSQ 449

Query: 1138 MLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDV 1190
             L EV+E EV +DS++  Y TPS++ ++ D  Q Y S   S E+Q    ALDV
Sbjct: 450  ELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQPYSSTLSSLEDQLACSALDV 502



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 66/307 (21%), Positives = 123/307 (40%), Gaps = 51/307 (16%)

Query: 136 PDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND-------EDEDEDVQVEEAEKV------ 182
           P +    ++ ++  +GC L   ++  L+P            ED+ V +   +K+      
Sbjct: 377 PLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSLALVDKIKKDQEE 436

Query: 183 LESSAP------REVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKV 236
           +E  +P      +E+ + +E +VPEDS+ E  +T S  H   D +QP+            
Sbjct: 437 IEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQPY------------ 484

Query: 237 NSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEK-- 294
           +STL      S  E Q A + L V  PT +A        +G LS  ++E+ I +   +  
Sbjct: 485 SSTL------SSLEDQLACSALDVASPTEAA--CPQGTWSGDLSHHRSEVQISQAQLEPS 536

Query: 295 ------LRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQ--NKYKYEECEDLIKSMLRNER 346
                 LR QL +       L ++   +    F AN    N++ ++E        ++N  
Sbjct: 537 TLVPSCLRLQLDQGFHCGNGLAQRGLSSTTCSFSANADSGNQWPFQELVLEPSLGMKNPP 596

Query: 347 QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKL--REGRDASRSLNQHLQALLTP 404
           Q +++ L       +  +    +  S    L  +R +L   + R A R    H ++   P
Sbjct: 597 QLEDDALEGSASNTQGRQVTGRIRASLVLILKTIRRRLPFSKWRLAFRFAGPHAESAEIP 656

Query: 405 DEPDKSQ 411
           +  ++ Q
Sbjct: 657 NTAERMQ 663



 Score = 39.7 bits (91), Expect = 0.018
 Identities = 26/71 (36%), Positives = 38/71 (53%), Gaps = 3/71 (4%)

Query: 1122 KEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEE 1181
            +E E+ Q  P PR    + + EE EV QDSL+ C  T S      +S Q +RS   +F+E
Sbjct: 179  EEVEKVQESPAPR---EVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKE 235

Query: 1182 QHISFALDVDN 1192
              +  AL V++
Sbjct: 236  HEVDSALVVES 246


>gi|221136848 neuroblastoma breakpoint family, member 6 isoform 2
            [Homo sapiens]
          Length = 638

 Score =  472 bits (1214), Expect = e-132
 Identities = 277/499 (55%), Positives = 337/499 (67%), Gaps = 47/499 (9%)

Query: 543  MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACF-LANQQNKYK 601
            MVVSA PLSSE+AEMNILE+N++LR QLAE  QQFR+LKEK  +TQ   + LANQ  KYK
Sbjct: 1    MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYK 60

Query: 602  YEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 661
             EE KD+I SVLR+E Q   EKLAE+L+QAEELRQYK LVHSQ +ELTQLREKLREGRDA
Sbjct: 61   CEEYKDIIDSVLRDELQ-SMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDA 119

Query: 662  SRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDV--QVE 719
            SR LN+HL+ LLTPD+PDKSQGQDL+EQLAEG RLA+ L  KLSPEND D DED   + E
Sbjct: 120  SRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDE 179

Query: 720  VAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVD 779
              EKVQ+S APRE+QK EEKEVP+DSLEECA+TCSNSH P +SNQPHR TKITF+E +VD
Sbjct: 180  EVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVD 239

Query: 780  STLIGSSSHV--EWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYS 837
            S L+  S H   E E+A++I PEN++D EEEE K PV PR+  +S               
Sbjct: 240  SALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPVPPRHHDKSN-------------- 285

Query: 838  TLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDI----GGHRWDQV------KKED----- 882
                      SY+    +F +L+EQ+VC A D+       +WD+       K+ D     
Sbjct: 286  ----------SYRHREVSFLALDEQKVCSAQDVARDYSNPKWDETSLGFLEKQSDLEEVK 335

Query: 883  -QEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGW 941
             QE   PRLSR  L     E+ Q+SLD C  TPS   +LT S  PY S  Y  E ++V  
Sbjct: 336  GQETVAPRLSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSL 395

Query: 942  ALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQP 1001
            AL +D+I+K QE  EDQ P CPRLS+EL + KE EV +DS++  Y TPS + ++ D  QP
Sbjct: 396  AL-VDKIKKDQEEIEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQP 454

Query: 1002 YRSAVYSLEEQYLGLALDV 1020
            Y S + SLE+Q    ALDV
Sbjct: 455  YSSTLSSLEDQLACSALDV 473



 Score =  363 bits (931), Expect = e-100
 Identities = 235/520 (45%), Positives = 305/520 (58%), Gaps = 58/520 (11%)

Query: 272 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGF-LANQQNKYK 330
           MVVSA PLSSE+AEMNILE+N++LR QLAE  QQFR+LKEK  +TQ   + LANQ  KYK
Sbjct: 1   MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYK 60

Query: 331 YEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 390
            EE +D+I S+LR+E Q   EKLAE+L+QAEELRQYK LVHSQ +ELTQLREKLREGRDA
Sbjct: 61  CEEYKDIIDSVLRDELQ-SMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDA 119

Query: 391 SRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDV--QVE 448
           SR LN+HL+ LLTPD+PDKSQGQDL+EQLAEG RLA+HLV KLSPENDEDEDED   + E
Sbjct: 120 SRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDE 179

Query: 449 EAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVN 508
           E EKV ES APREVQK EE +VP+DSLEECA+TCSNSH P +SNQPH++  ITF+E +V+
Sbjct: 180 EVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVD 239

Query: 509 SALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRP 568
           SALVV+ E  HDE ++A+NI P                       + +    E    + P
Sbjct: 240 SALVVESEHPHDEEEEALNIPP---------------------ENQNDHEEEEGKAPVPP 278

Query: 569 QLAEKKQQFRNLKEKCFVT---QLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLA 625
           +  +K   +R+ +E  F+    Q  C   +    Y   +  +     L  +   +E K  
Sbjct: 279 RHHDKSNSYRH-REVSFLALDEQKVCSAQDVARDYSNPKWDETSLGFLEKQSDLEEVKGQ 337

Query: 626 EQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQD 685
           E +  A  L +  + V   E     + ++  +G   + S+   L     P        +D
Sbjct: 338 ETV--APRLSRGPLRVDKHE-----IPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFED 390

Query: 686 LQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVP 742
            Q  LA        L  K+  + +   D           Q    PR   E+ + +E+EVP
Sbjct: 391 KQVSLA--------LVDKIKKDQEEIED-----------QSPPCPRLSQELPEVKEQEVP 431

Query: 743 EDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 782
           EDS+ E  +T S  H   D +QP+  T  + E+    S L
Sbjct: 432 EDSVNEVYLTPSVHHDVSDCHQPYSSTLSSLEDQLACSAL 471



 Score =  359 bits (921), Expect = 1e-98
 Identities = 233/516 (45%), Positives = 308/516 (59%), Gaps = 46/516 (8%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGF-LANRQKKYK 59
           MVVSA P SSE+AE NILEIN++LR QLAE+ QQFR+LKEK  +TQ   + LAN+ KKYK
Sbjct: 1   MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYK 60

Query: 60  YEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 119
            EE KD+I  +LR+E Q   EKLAE+L+QAEELRQYK LVHSQ +ELTQLREKLREGRDA
Sbjct: 61  CEEYKDIIDSVLRDELQ-SMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDA 119

Query: 120 SRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDV--QVE 177
           SR LN+HL+ LLTPD+PDKSQGQDL+EQLAEG RLA+HLV KLSPENDEDEDED   + E
Sbjct: 120 SRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDE 179

Query: 178 EAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVN 237
           E EKV ES APREVQK EE +VP+DSLEECA+TCSNSH P +SNQPH++  ITF+E +V+
Sbjct: 180 EVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVD 239

Query: 238 STLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRP 297
           S LVV+ E  HDE ++A+NI P               +      E+ +  +   +     
Sbjct: 240 SALVVESEHPHDEEEEALNIPP--------------ENQNDHEEEEGKAPVPPRHHDKSN 285

Query: 298 QLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQL 357
               ++  F  L E+   +  A  +A   +  K++E      S+   E+Q   E++  Q 
Sbjct: 286 SYRHREVSFLALDEQKVCS--AQDVARDYSNPKWDE-----TSLGFLEKQSDLEEVKGQE 338

Query: 358 KQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE 417
             A  L +  + V   E     + ++  +G   + S+   L     P        +D Q 
Sbjct: 339 TVAPRLSRGPLRVDKHE-----IPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQV 393

Query: 418 QLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEE 477
            LA        LV K+  + +E ED+                +E+ + +E +VPEDS+ E
Sbjct: 394 SLA--------LVDKIKKDQEEIEDQSPPCPRLS--------QELPEVKEQEVPEDSVNE 437

Query: 478 CAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVV 513
             +T S  H   D +QP+ +   + E+    SAL V
Sbjct: 438 VYLTPSVHHDVSDCHQPYSSTLSSLEDQLACSALDV 473



 Score =  115 bits (288), Expect = 3e-25
 Identities = 101/331 (30%), Positives = 156/331 (47%), Gaps = 51/331 (15%)

Query: 876  DQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILE 935
            D+  ++ QE+  PR   E+   +  EV QDSL+ C  T S     ++S QP+RS     +
Sbjct: 178  DEEVEKVQESPAPR---EVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFK 234

Query: 936  QQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLEL 995
            +  V  AL ++   ++   EE++  + P  ++   +E+E +            P  + + 
Sbjct: 235  EHEVDSALVVES--EHPHDEEEEALNIPPENQNDHEEEEGKA---------PVPPRHHDK 283

Query: 996  PDLGQPYRSAVYSLEEQYLGLALDVDRI----------------KKDQEEEEDQGPPCPR 1039
             +  +    +  +L+EQ +  A DV R                 + D EE + Q    PR
Sbjct: 284  SNSYRHREVSFLALDEQKVCSAQDVARDYSNPKWDETSLGFLEKQSDLEEVKGQETVAPR 343

Query: 1040 LSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIE 1099
            LSR  L   + E+ Q+SLD C  TPS   +   S  PY S+ Y+ E+K V  +L V +I+
Sbjct: 344  LSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSLAL-VDKIK 402

Query: 1100 KKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTP 1159
            K                     +E  EDQ+PPCPRLS  L EV+E EV +DS++  Y TP
Sbjct: 403  KD--------------------QEEIEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTP 442

Query: 1160 SMYFELPDSFQHYRSVFYSFEEQHISFALDV 1190
            S++ ++ D  Q Y S   S E+Q    ALDV
Sbjct: 443  SVHHDVSDCHQPYSSTLSSLEDQLACSALDV 473



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 66/307 (21%), Positives = 123/307 (40%), Gaps = 51/307 (16%)

Query: 136 PDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND-------EDEDEDVQVEEAEKV------ 182
           P +    ++ ++  +GC L   ++  L+P            ED+ V +   +K+      
Sbjct: 348 PLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSLALVDKIKKDQEE 407

Query: 183 LESSAP------REVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKV 236
           +E  +P      +E+ + +E +VPEDS+ E  +T S  H   D +QP+            
Sbjct: 408 IEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQPY------------ 455

Query: 237 NSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEK-- 294
           +STL      S  E Q A + L V  PT +A        +G LS  ++E+ I +   +  
Sbjct: 456 SSTL------SSLEDQLACSALDVASPTEAA--CPQGTWSGDLSHHRSEVQISQAQLEPS 507

Query: 295 ------LRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQ--NKYKYEECEDLIKSMLRNER 346
                 LR QL +       L ++   +    F AN    N++ ++E        ++N  
Sbjct: 508 TLVPSCLRLQLDQGFHCGNGLAQRGLSSTTCSFSANADSGNQWPFQELVLEPSLGMKNPP 567

Query: 347 QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKL--REGRDASRSLNQHLQALLTP 404
           Q +++ L       +  +    +  S    L  +R +L   + R A R    H ++   P
Sbjct: 568 QLEDDALEGSASNTQGRQVTGRIRASLVLILKTIRRRLPFSKWRLAFRFAGPHAESAEIP 627

Query: 405 DEPDKSQ 411
           +  ++ Q
Sbjct: 628 NTAERMQ 634



 Score = 39.7 bits (91), Expect = 0.018
 Identities = 26/71 (36%), Positives = 38/71 (53%), Gaps = 3/71 (4%)

Query: 1122 KEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEE 1181
            +E E+ Q  P PR    + + EE EV QDSL+ C  T S      +S Q +RS   +F+E
Sbjct: 179  EEVEKVQESPAPR---EVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKE 235

Query: 1182 QHISFALDVDN 1192
              +  AL V++
Sbjct: 236  HEVDSALVVES 246


>gi|221218991 neuroblastoma breakpoint family, member 4 [Homo sapiens]
          Length = 638

 Score =  472 bits (1214), Expect = e-132
 Identities = 277/499 (55%), Positives = 337/499 (67%), Gaps = 47/499 (9%)

Query: 543  MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACF-LANQQNKYK 601
            MVVSA PLSSE+AEMNILE+N++LR QLAE  QQFR+LKEK  +TQ   + LANQ  KYK
Sbjct: 1    MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYK 60

Query: 602  YEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 661
             EE KD+I SVLR+E Q   EKLAE+L+QAEELRQYK LVHSQ +ELTQLREKLREGRDA
Sbjct: 61   CEEYKDIIDSVLRDELQ-SMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDA 119

Query: 662  SRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDV--QVE 719
            SR LN+HL+ LLTPD+PDKSQGQDL+EQLAEG RLA+ L  KLSPEND D DED   + E
Sbjct: 120  SRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDE 179

Query: 720  VAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVD 779
              EKVQ+S APRE+QK EEKEVP+DSLEECA+TCSNSH P +SNQPHR TKITF+E +VD
Sbjct: 180  EVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVD 239

Query: 780  STLIGSSSHV--EWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYS 837
            S L+  S H   E E+A++I PEN++D EEEE K PV PR+  +S               
Sbjct: 240  SALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPVPPRHHDKSN-------------- 285

Query: 838  TLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDI----GGHRWDQV------KKED----- 882
                      SY+    +F +L+EQ+VC A D+       +WD+       K+ D     
Sbjct: 286  ----------SYRHREVSFLALDEQKVCSAQDVARDYSNPKWDETSLGFLEKQSDLEEVK 335

Query: 883  -QEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGW 941
             QE   PRLSR  L     E+ Q+SLD C  TPS   +LT S  PY S  Y  E ++V  
Sbjct: 336  GQETVAPRLSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSL 395

Query: 942  ALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQP 1001
            AL +D+I+K QE  EDQ P CPRLS+EL + KE EV +DS++  Y TPS + ++ D  QP
Sbjct: 396  AL-VDKIKKDQEEIEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQP 454

Query: 1002 YRSAVYSLEEQYLGLALDV 1020
            Y S + SLE+Q    ALDV
Sbjct: 455  YSSTLSSLEDQLACSALDV 473



 Score =  363 bits (931), Expect = e-100
 Identities = 235/520 (45%), Positives = 305/520 (58%), Gaps = 58/520 (11%)

Query: 272 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGF-LANQQNKYK 330
           MVVSA PLSSE+AEMNILE+N++LR QLAE  QQFR+LKEK  +TQ   + LANQ  KYK
Sbjct: 1   MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYK 60

Query: 331 YEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 390
            EE +D+I S+LR+E Q   EKLAE+L+QAEELRQYK LVHSQ +ELTQLREKLREGRDA
Sbjct: 61  CEEYKDIIDSVLRDELQ-SMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDA 119

Query: 391 SRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDV--QVE 448
           SR LN+HL+ LLTPD+PDKSQGQDL+EQLAEG RLA+HLV KLSPENDEDEDED   + E
Sbjct: 120 SRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDE 179

Query: 449 EAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVN 508
           E EKV ES APREVQK EE +VP+DSLEECA+TCSNSH P +SNQPH++  ITF+E +V+
Sbjct: 180 EVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVD 239

Query: 509 SALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRP 568
           SALVV+ E  HDE ++A+NI P                       + +    E    + P
Sbjct: 240 SALVVESEHPHDEEEEALNIPP---------------------ENQNDHEEEEGKAPVPP 278

Query: 569 QLAEKKQQFRNLKEKCFVT---QLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLA 625
           +  +K   +R+ +E  F+    Q  C   +    Y   +  +     L  +   +E K  
Sbjct: 279 RHHDKSNSYRH-REVSFLALDEQKVCSAQDVARDYSNPKWDETSLGFLEKQSDLEEVKGQ 337

Query: 626 EQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQD 685
           E +  A  L +  + V   E     + ++  +G   + S+   L     P        +D
Sbjct: 338 ETV--APRLSRGPLRVDKHE-----IPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFED 390

Query: 686 LQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPR---EMQKAEEKEVP 742
            Q  LA        L  K+  + +   D           Q    PR   E+ + +E+EVP
Sbjct: 391 KQVSLA--------LVDKIKKDQEEIED-----------QSPPCPRLSQELPEVKEQEVP 431

Query: 743 EDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 782
           EDS+ E  +T S  H   D +QP+  T  + E+    S L
Sbjct: 432 EDSVNEVYLTPSVHHDVSDCHQPYSSTLSSLEDQLACSAL 471



 Score =  359 bits (921), Expect = 1e-98
 Identities = 233/516 (45%), Positives = 308/516 (59%), Gaps = 46/516 (8%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGF-LANRQKKYK 59
           MVVSA P SSE+AE NILEIN++LR QLAE+ QQFR+LKEK  +TQ   + LAN+ KKYK
Sbjct: 1   MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYK 60

Query: 60  YEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 119
            EE KD+I  +LR+E Q   EKLAE+L+QAEELRQYK LVHSQ +ELTQLREKLREGRDA
Sbjct: 61  CEEYKDIIDSVLRDELQ-SMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDA 119

Query: 120 SRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDV--QVE 177
           SR LN+HL+ LLTPD+PDKSQGQDL+EQLAEG RLA+HLV KLSPENDEDEDED   + E
Sbjct: 120 SRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDE 179

Query: 178 EAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVN 237
           E EKV ES APREVQK EE +VP+DSLEECA+TCSNSH P +SNQPH++  ITF+E +V+
Sbjct: 180 EVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVD 239

Query: 238 STLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRP 297
           S LVV+ E  HDE ++A+NI P               +      E+ +  +   +     
Sbjct: 240 SALVVESEHPHDEEEEALNIPP--------------ENQNDHEEEEGKAPVPPRHHDKSN 285

Query: 298 QLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQL 357
               ++  F  L E+   +  A  +A   +  K++E      S+   E+Q   E++  Q 
Sbjct: 286 SYRHREVSFLALDEQKVCS--AQDVARDYSNPKWDE-----TSLGFLEKQSDLEEVKGQE 338

Query: 358 KQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE 417
             A  L +  + V   E     + ++  +G   + S+   L     P        +D Q 
Sbjct: 339 TVAPRLSRGPLRVDKHE-----IPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQV 393

Query: 418 QLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEE 477
            LA        LV K+  + +E ED+                +E+ + +E +VPEDS+ E
Sbjct: 394 SLA--------LVDKIKKDQEEIEDQSPPCPRLS--------QELPEVKEQEVPEDSVNE 437

Query: 478 CAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVV 513
             +T S  H   D +QP+ +   + E+    SAL V
Sbjct: 438 VYLTPSVHHDVSDCHQPYSSTLSSLEDQLACSALDV 473



 Score =  115 bits (288), Expect = 3e-25
 Identities = 101/331 (30%), Positives = 156/331 (47%), Gaps = 51/331 (15%)

Query: 876  DQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILE 935
            D+  ++ QE+  PR   E+   +  EV QDSL+ C  T S     ++S QP+RS     +
Sbjct: 178  DEEVEKVQESPAPR---EVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFK 234

Query: 936  QQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLEL 995
            +  V  AL ++   ++   EE++  + P  ++   +E+E +            P  + + 
Sbjct: 235  EHEVDSALVVES--EHPHDEEEEALNIPPENQNDHEEEEGKA---------PVPPRHHDK 283

Query: 996  PDLGQPYRSAVYSLEEQYLGLALDVDRI----------------KKDQEEEEDQGPPCPR 1039
             +  +    +  +L+EQ +  A DV R                 + D EE + Q    PR
Sbjct: 284  SNSYRHREVSFLALDEQKVCSAQDVARDYSNPKWDETSLGFLEKQSDLEEVKGQETVAPR 343

Query: 1040 LSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIE 1099
            LSR  L   + E+ Q+SLD C  TPS   +   S  PY S+ Y+ E+K V  +L V +I+
Sbjct: 344  LSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSLAL-VDKIK 402

Query: 1100 KKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTP 1159
            K                     +E  EDQ+PPCPRLS  L EV+E EV +DS++  Y TP
Sbjct: 403  KD--------------------QEEIEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTP 442

Query: 1160 SMYFELPDSFQHYRSVFYSFEEQHISFALDV 1190
            S++ ++ D  Q Y S   S E+Q    ALDV
Sbjct: 443  SVHHDVSDCHQPYSSTLSSLEDQLACSALDV 473



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 55/247 (22%), Positives = 102/247 (41%), Gaps = 49/247 (19%)

Query: 136 PDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND-------EDEDEDVQVEEAEKV------ 182
           P +    ++ ++  +GC L   ++  L+P            ED+ V +   +K+      
Sbjct: 348 PLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSLALVDKIKKDQEE 407

Query: 183 LESSAP------REVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKV 236
           +E  +P      +E+ + +E +VPEDS+ E  +T S  H   D +QP+            
Sbjct: 408 IEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQPY------------ 455

Query: 237 NSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEK-- 294
           +STL      S  E Q A + L V  PT +A        +G LS  ++E+ + +   +  
Sbjct: 456 SSTL------SSLEDQLACSALDVASPTEAA--CPQGTWSGDLSHHQSEVQVSQAQLEPS 507

Query: 295 ------LRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQ--NKYKYEECEDLIKSMLRNER 346
                 LR QL +       L ++   +    F AN    N++ ++E        ++N  
Sbjct: 508 TLVPSCLRLQLDQGFHCGNGLAQRGLSSTTCSFSANADSGNQWPFQELVLEPSLGMKNPP 567

Query: 347 QFKEEKL 353
           Q +++ L
Sbjct: 568 QLEDDAL 574



 Score = 39.7 bits (91), Expect = 0.018
 Identities = 26/71 (36%), Positives = 38/71 (53%), Gaps = 3/71 (4%)

Query: 1122 KEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEE 1181
            +E E+ Q  P PR    + + EE EV QDSL+ C  T S      +S Q +RS   +F+E
Sbjct: 179  EEVEKVQESPAPR---EVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKE 235

Query: 1182 QHISFALDVDN 1192
              +  AL V++
Sbjct: 236  HEVDSALVVES 246


>gi|114158664 hypothetical protein LOC343505 [Homo sapiens]
          Length = 421

 Score =  472 bits (1214), Expect = e-132
 Identities = 250/351 (71%), Positives = 283/351 (80%), Gaps = 10/351 (2%)

Query: 530 PVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQL 589
           PVPG TSSATNV+MVVSAGP SSEKAEMNILE+NEKLRPQLAE KQQFRN+K+K  VTQ+
Sbjct: 8   PVPGSTSSATNVTMVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFRNMKQKFLVTQM 67

Query: 590 ACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELT 649
           A FLANQQNKYKYEECKDLIKS+LR E QFKEEKLAEQLKQAEELRQYKVLVHSQEREL 
Sbjct: 68  AGFLANQQNKYKYEECKDLIKSMLREELQFKEEKLAEQLKQAEELRQYKVLVHSQERELI 127

Query: 650 QLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPEND 709
           QLREKLREGRDAS SLNQHLQALLTPD+ D SQGQD +EQLAEGCRLA+ L  KLSPEND
Sbjct: 128 QLREKLREGRDASHSLNQHLQALLTPDKHDNSQGQDFREQLAEGCRLARHLVHKLSPEND 187

Query: 710 NDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKT 769
            D DE+ + +  +KVQ+S APRE QKAEEKEVPEDSLEECAIT SNSHGP DSN PH+  
Sbjct: 188 TDEDENDKTKELDKVQESPAPREEQKAEEKEVPEDSLEECAITYSNSHGPSDSNPPHKNI 247

Query: 770 KITFEEDKVDSTLI--GSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR--------NL 819
           KIT EEDKV+S L+    SS  EW+DA++I+ EN++DDEEEE K PV P+         L
Sbjct: 248 KITSEEDKVNSILVVDSESSQDEWQDALNILLENQNDDEEEEGKAPVPPQVTLWICGLKL 307

Query: 820 QESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDI 870
           QESEE+EV Q+S +E  +T     ++  SYQ   GTF +L EQ+VC A D+
Sbjct: 308 QESEEKEVLQDSPEERVTTSCSDHDVSQSYQPCEGTFLALVEQKVCSAQDV 358



 Score =  440 bits (1131), Expect = e-123
 Identities = 226/271 (83%), Positives = 241/271 (88%)

Query: 259 PVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQL 318
           PVPG TSSATNV+MVVSAGP SSEKAEMNILE+NEKLRPQLAE KQQFRN+K+K  VTQ+
Sbjct: 8   PVPGSTSSATNVTMVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFRNMKQKFLVTQM 67

Query: 319 AGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELT 378
           AGFLANQQNKYKYEEC+DLIKSMLR E QFKEEKLAEQLKQAEELRQYKVLVHSQEREL 
Sbjct: 68  AGFLANQQNKYKYEECKDLIKSMLREELQFKEEKLAEQLKQAEELRQYKVLVHSQERELI 127

Query: 379 QLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND 438
           QLREKLREGRDAS SLNQHLQALLTPD+ D SQGQD +EQLAEGCRLA+HLV KLSPEND
Sbjct: 128 QLREKLREGRDASHSLNQHLQALLTPDKHDNSQGQDFREQLAEGCRLARHLVHKLSPEND 187

Query: 439 EDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNI 498
            DEDE+ + +E +KV ES APRE QKAEE +VPEDSLEECAIT SNSHGP DSN PHKNI
Sbjct: 188 TDEDENDKTKELDKVQESPAPREEQKAEEKEVPEDSLEECAITYSNSHGPSDSNPPHKNI 247

Query: 499 NITFEEDKVNSALVVDRESSHDECQDAVNIL 529
            IT EEDKVNS LVVD ESS DE QDA+NIL
Sbjct: 248 KITSEEDKVNSILVVDSESSQDEWQDALNIL 278



 Score =  420 bits (1079), Expect = e-117
 Identities = 215/258 (83%), Positives = 228/258 (88%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
           MVVSAGPWSSEKAE NILEINEKLRPQLAENKQQFRN+K+K  VTQ+AGFLAN+Q KYKY
Sbjct: 21  MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFRNMKQKFLVTQMAGFLANQQNKYKY 80

Query: 61  EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
           EECKDLIK MLR E QFKEEKLAEQLKQAEELRQYKVLVHSQEREL QLREKLREGRDAS
Sbjct: 81  EECKDLIKSMLREELQFKEEKLAEQLKQAEELRQYKVLVHSQERELIQLREKLREGRDAS 140

Query: 121 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
            SLNQHLQALLTPD+ D SQGQD +EQLAEGCRLA+HLV KLSPEND DEDE+ + +E +
Sbjct: 141 HSLNQHLQALLTPDKHDNSQGQDFREQLAEGCRLARHLVHKLSPENDTDEDENDKTKELD 200

Query: 181 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
           KV ES APRE QKAEE +VPEDSLEECAIT SNSHGP DSN PHKNI IT EEDKVNS L
Sbjct: 201 KVQESPAPREEQKAEEKEVPEDSLEECAITYSNSHGPSDSNPPHKNIKITSEEDKVNSIL 260

Query: 241 VVDRESSHDECQDAVNIL 258
           VVD ESS DE QDA+NIL
Sbjct: 261 VVDSESSQDEWQDALNIL 278



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 57/209 (27%), Positives = 93/209 (44%), Gaps = 27/209 (12%)

Query: 919  ELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVL 978
            +L + C+  R   + L  +      D DE +K +E+++ Q+   PR  ++    +E EV 
Sbjct: 167  QLAEGCRLARHLVHKLSPEN---DTDEDENDKTKELDKVQESPAPREEQKA---EEKEVP 220

Query: 979  QDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD----------------R 1022
            +DSL+ C  T S      D   P+++   + EE  +   L VD                 
Sbjct: 221  EDSLEECAITYSNSHGPSDSNPPHKNIKITSEEDKVNSILVVDSESSQDEWQDALNILLE 280

Query: 1023 IKKDQEEEEDQGPPCPRLS-----RELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPY 1077
             + D EEEE + P  P+++      +L E+ E EVLQDS +   +T  S  +   S  P 
Sbjct: 281  NQNDDEEEEGKAPVPPQVTLWICGLKLQESEEKEVLQDSPEERVTTSCSDHDVSQSYQPC 340

Query: 1078 GSSFYALEEKHVGFSLDVGEIEKKGKGKK 1106
              +F AL E+ V  + DV       KG++
Sbjct: 341  EGTFLALVEQKVCSAQDVASEHSNSKGEE 369



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 55/193 (28%), Positives = 81/193 (41%), Gaps = 12/193 (6%)

Query: 1019 DVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYG 1078
            D D   K +E ++ Q  P PR   E  +A E EV +DSL+ C  T S+     DS  P+ 
Sbjct: 189  DEDENDKTKELDKVQESPAPR---EEQKAEEKEVPEDSLEECAITYSNSHGPSDSNPPHK 245

Query: 1079 SSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLS-- 1136
            +     EE  V   L V     + + +             +   E EE + P  P+++  
Sbjct: 246  NIKITSEEDKVNSILVVDSESSQDEWQDALNILL----ENQNDDEEEEGKAPVPPQVTLW 301

Query: 1137 --GM-LMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVDNR 1193
              G+ L E EE EVLQDS +   +T     ++  S+Q     F +  EQ +  A DV + 
Sbjct: 302  ICGLKLQESEEKEVLQDSPEERVTTSCSDHDVSQSYQPCEGTFLALVEQKVCSAQDVASE 361

Query: 1194 FLTLMGTSLHLVF 1206
                 G    L F
Sbjct: 362  HSNSKGEETPLGF 374


>gi|239758011 PREDICTED: hypothetical protein LOC728841, partial [Homo
            sapiens]
          Length = 166

 Score =  231 bits (590), Expect = 2e-60
 Identities = 115/145 (79%), Positives = 125/145 (86%), Gaps = 1/145 (0%)

Query: 1068 LEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEED 1127
            LEQPDSC PYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS KK+RRRGRKEGEED
Sbjct: 1    LEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS-KKKRRRGRKEGEED 59

Query: 1128 QNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFA 1187
            QNPPCPRLS  L++ +EPEVLQDSLDRCYSTPS Y ELPD  Q Y S  YS EEQ++  A
Sbjct: 60   QNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLA 119

Query: 1188 LDVDNRFLTLMGTSLHLVFQMGVIF 1212
            LDVD+ +LT+   SLHLVFQ+GVIF
Sbjct: 120  LDVDSEYLTMKVISLHLVFQIGVIF 144



 Score =  166 bits (419), Expect = 2e-40
 Identities = 86/123 (69%), Positives = 94/123 (76%), Gaps = 19/123 (15%)

Query: 918  LELTDSCQPYRSAFYILEQQRVGWALDMDEIEKY-------------------QEVEEDQ 958
            LE  DSCQPY S+FY LE++ VG++LD+ EIEK                    +E EEDQ
Sbjct: 1    LEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQ 60

Query: 959  DPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLAL 1018
            +P CPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLAL
Sbjct: 61   NPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLAL 120

Query: 1019 DVD 1021
            DVD
Sbjct: 121  DVD 123



 Score =  125 bits (313), Expect = 3e-28
 Identities = 66/122 (54%), Positives = 81/122 (66%), Gaps = 19/122 (15%)

Query: 993  LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEEEEDQ 1033
            LE PD  QPY S+ Y+LEE+++G +LDV  I+K                    +E EEDQ
Sbjct: 1    LEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQ 60

Query: 1034 GPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSL 1093
             PPCPRLSRELL+  EPEVLQDSLDRCYSTPS  LE PD   PY S+ Y+LEE+++G +L
Sbjct: 61   NPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLAL 120

Query: 1094 DV 1095
            DV
Sbjct: 121  DV 122



 Score =  108 bits (270), Expect = 3e-23
 Identities = 62/118 (52%), Positives = 75/118 (63%), Gaps = 19/118 (16%)

Query: 848 SYQSYSGTFHSLEEQQVCMAVDIG------------GHRWDQVKK-------EDQEATGP 888
           S Q Y  +F++LEE+ V  ++D+G            G R  + ++       EDQ    P
Sbjct: 6   SCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQNPPCP 65

Query: 889 RLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMD 946
           RLSRELLDEK PEVLQDSLDRCYSTPSGYLEL D  QPY SA Y LE+Q +G ALD+D
Sbjct: 66  RLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 123



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 28/68 (41%), Positives = 39/68 (57%), Gaps = 3/68 (4%)

Query: 806 EEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQ 862
           E EE++ P  PR    L + +E EV Q+S D  YST S   E+    Q YS   +SLEEQ
Sbjct: 55  EGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQ 114

Query: 863 QVCMAVDI 870
            + +A+D+
Sbjct: 115 YLGLALDV 122



 Score = 32.0 bits (71), Expect = 3.7
 Identities = 20/57 (35%), Positives = 29/57 (50%)

Query: 460 REVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRE 516
           RE+   +E +V +DSL+ C  T S      D  QP+ +   + EE  +  AL VD E
Sbjct: 69  RELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDSE 125


>gi|239747446 PREDICTED: similar to Neuroblastoma breakpoint family
           member 6-like protein [Homo sapiens]
          Length = 298

 Score =  119 bits (297), Expect = 2e-26
 Identities = 76/190 (40%), Positives = 108/190 (56%), Gaps = 9/190 (4%)

Query: 543 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACF-LANQQNKYK 601
           M VSA      +AEM+ILE N+ LR +L + KQ F++L EK   ++   + L N   KYK
Sbjct: 1   MAVSATTCFGPRAEMSILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60

Query: 602 YEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 661
            EECKDLI+SVL  E QF+E +LAE  + A  LR +  L+ +Q  ELT LR+K++EGR  
Sbjct: 61  CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKIQEGRGV 120

Query: 662 SRSLNQHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDN-DHD 713
                QH+       + LL   +    Q Q   EQ+ +G +L + L +KL+ EN N   +
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQGSQLTEILVRKLATENHNGKKN 180

Query: 714 EDVQVEVAEK 723
           ED Q  +A +
Sbjct: 181 EDRQKPLAPR 190



 Score =  115 bits (288), Expect = 3e-25
 Identities = 73/184 (39%), Positives = 107/184 (58%), Gaps = 9/184 (4%)

Query: 272 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGF-LANQQNKYK 330
           M VSA      +AEM+ILE N+ LR +L + KQ F++L EK   ++   + L N   KYK
Sbjct: 1   MAVSATTCFGPRAEMSILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60

Query: 331 YEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 390
            EEC+DLI+S+L  E QF+E +LAE  + A  LR +  L+ +Q  ELT LR+K++EGR  
Sbjct: 61  CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKIQEGRGV 120

Query: 391 SRSLNQHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEN-DEDED 442
                QH+       + LL   +    Q Q   EQ+ +G +L + LV+KL+ EN +  ++
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQGSQLTEILVRKLATENHNGKKN 180

Query: 443 EDVQ 446
           ED Q
Sbjct: 181 EDRQ 184



 Score =  112 bits (280), Expect = 2e-24
 Identities = 72/184 (39%), Positives = 106/184 (57%), Gaps = 9/184 (4%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGF-LANRQKKYK 59
           M VSA      +AE +ILE N+ LR +L + KQ F++L EK   ++   + L N  +KYK
Sbjct: 1   MAVSATTCFGPRAEMSILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60

Query: 60  YEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 119
            EECKDLI+ +L  E QF+E +LAE  + A  LR +  L+ +Q  ELT LR+K++EGR  
Sbjct: 61  CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKIQEGRGV 120

Query: 120 SRSLNQHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEN-DEDED 171
                QH+       + LL   +    Q Q   EQ+ +G +L + LV+KL+ EN +  ++
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQGSQLTEILVRKLATENHNGKKN 180

Query: 172 EDVQ 175
           ED Q
Sbjct: 181 EDRQ 184


>gi|239741304 PREDICTED: similar to Neuroblastoma breakpoint family
           member 6-like protein [Homo sapiens]
          Length = 298

 Score =  116 bits (290), Expect = 1e-25
 Identities = 75/190 (39%), Positives = 107/190 (56%), Gaps = 9/190 (4%)

Query: 543 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACF-LANQQNKYK 601
           M VSA      +AE++ILE N+ LR +L + KQ F++L EK   ++   + L N   KYK
Sbjct: 1   MAVSATTCFGPRAEISILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60

Query: 602 YEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 661
            EECKDLI+SVL  E QF+E +LAE  + A  LR +  L+ +Q  ELT LR+K +EGR  
Sbjct: 61  CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKTQEGRGV 120

Query: 662 SRSLNQHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDN-DHD 713
                QH+       + LL   +    Q Q   EQ+ +G +L + L +KL+ EN N   +
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQGSQLTEILVRKLATENHNGKKN 180

Query: 714 EDVQVEVAEK 723
           ED Q  +A +
Sbjct: 181 EDRQKPLAPR 190



 Score =  112 bits (281), Expect = 2e-24
 Identities = 72/184 (39%), Positives = 106/184 (57%), Gaps = 9/184 (4%)

Query: 272 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGF-LANQQNKYK 330
           M VSA      +AE++ILE N+ LR +L + KQ F++L EK   ++   + L N   KYK
Sbjct: 1   MAVSATTCFGPRAEISILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60

Query: 331 YEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 390
            EEC+DLI+S+L  E QF+E +LAE  + A  LR +  L+ +Q  ELT LR+K +EGR  
Sbjct: 61  CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKTQEGRGV 120

Query: 391 SRSLNQHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEN-DEDED 442
                QH+       + LL   +    Q Q   EQ+ +G +L + LV+KL+ EN +  ++
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQGSQLTEILVRKLATENHNGKKN 180

Query: 443 EDVQ 446
           ED Q
Sbjct: 181 EDRQ 184



 Score =  111 bits (277), Expect = 5e-24
 Identities = 72/184 (39%), Positives = 105/184 (57%), Gaps = 9/184 (4%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGF-LANRQKKYK 59
           M VSA      +AE +ILE N+ LR +L + KQ F++L EK   ++   + L N  +KYK
Sbjct: 1   MAVSATTCFGPRAEISILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60

Query: 60  YEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 119
            EECKDLI+ +L  E QF+E +LAE  + A  LR +  L+ +Q  ELT LR+K +EGR  
Sbjct: 61  CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKTQEGRGV 120

Query: 120 SRSLNQHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEN-DEDED 171
                QH+       + LL   +    Q Q   EQ+ +G +L + LV+KL+ EN +  ++
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQGSQLTEILVRKLATENHNGKKN 180

Query: 172 EDVQ 175
           ED Q
Sbjct: 181 EDRQ 184


>gi|239741281 PREDICTED: Neuroblastoma breakpoint family member
           6-like protein [Homo sapiens]
          Length = 322

 Score =  116 bits (290), Expect = 1e-25
 Identities = 75/190 (39%), Positives = 107/190 (56%), Gaps = 9/190 (4%)

Query: 543 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACF-LANQQNKYK 601
           M VSA      +AE++ILE N+ LR +L + KQ F++L EK   ++   + L N   KYK
Sbjct: 1   MAVSATTCFGPRAEISILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60

Query: 602 YEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 661
            EECKDLI+SVL  E QF+E +LAE  + A  LR +  L+ +Q  ELT LR+K +EGR  
Sbjct: 61  CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKTQEGRGV 120

Query: 662 SRSLNQHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDN-DHD 713
                QH+       + LL   +    Q Q   EQ+ +G +L + L +KL+ EN N   +
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQGSQLTEILVRKLATENHNGKKN 180

Query: 714 EDVQVEVAEK 723
           ED Q  +A +
Sbjct: 181 EDRQKPLAPR 190



 Score =  112 bits (281), Expect = 2e-24
 Identities = 72/184 (39%), Positives = 106/184 (57%), Gaps = 9/184 (4%)

Query: 272 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGF-LANQQNKYK 330
           M VSA      +AE++ILE N+ LR +L + KQ F++L EK   ++   + L N   KYK
Sbjct: 1   MAVSATTCFGPRAEISILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60

Query: 331 YEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 390
            EEC+DLI+S+L  E QF+E +LAE  + A  LR +  L+ +Q  ELT LR+K +EGR  
Sbjct: 61  CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKTQEGRGV 120

Query: 391 SRSLNQHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEN-DEDED 442
                QH+       + LL   +    Q Q   EQ+ +G +L + LV+KL+ EN +  ++
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQGSQLTEILVRKLATENHNGKKN 180

Query: 443 EDVQ 446
           ED Q
Sbjct: 181 EDRQ 184



 Score =  111 bits (277), Expect = 5e-24
 Identities = 72/184 (39%), Positives = 105/184 (57%), Gaps = 9/184 (4%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGF-LANRQKKYK 59
           M VSA      +AE +ILE N+ LR +L + KQ F++L EK   ++   + L N  +KYK
Sbjct: 1   MAVSATTCFGPRAEISILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60

Query: 60  YEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 119
            EECKDLI+ +L  E QF+E +LAE  + A  LR +  L+ +Q  ELT LR+K +EGR  
Sbjct: 61  CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKTQEGRGV 120

Query: 120 SRSLNQHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEN-DEDED 171
                QH+       + LL   +    Q Q   EQ+ +G +L + LV+KL+ EN +  ++
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQGSQLTEILVRKLATENHNGKKN 180

Query: 172 EDVQ 175
           ED Q
Sbjct: 181 EDRQ 184


>gi|239752894 PREDICTED: Neuroblastoma breakpoint family member
           6-like protein [Homo sapiens]
          Length = 298

 Score =  113 bits (283), Expect = 1e-24
 Identities = 75/190 (39%), Positives = 105/190 (55%), Gaps = 9/190 (4%)

Query: 543 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACF-LANQQNKYK 601
           M VSA      +AE++ILE N+ LR +L + KQ F++L EK   ++   + L N   KYK
Sbjct: 1   MAVSATTCFGPRAEISILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60

Query: 602 YEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 661
            EECKDLI+SVL  E QF+E +LAE  + A  LR +  L+ +Q  ELT LR+K +EGR  
Sbjct: 61  CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKTQEGRGV 120

Query: 662 SRSLNQHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDN-DHD 713
                QH+       + LL        Q Q   EQ+ +G +L + L +KL  EN N   +
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTGIAYYQRQRFCEQMVQGSQLTEILVRKLVTENHNGKKN 180

Query: 714 EDVQVEVAEK 723
           ED Q  +A +
Sbjct: 181 EDRQKPLAPR 190



 Score =  110 bits (274), Expect = 1e-23
 Identities = 72/184 (39%), Positives = 104/184 (56%), Gaps = 9/184 (4%)

Query: 272 MVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGF-LANQQNKYK 330
           M VSA      +AE++ILE N+ LR +L + KQ F++L EK   ++   + L N   KYK
Sbjct: 1   MAVSATTCFGPRAEISILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60

Query: 331 YEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 390
            EEC+DLI+S+L  E QF+E +LAE  + A  LR +  L+ +Q  ELT LR+K +EGR  
Sbjct: 61  CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKTQEGRGV 120

Query: 391 SRSLNQHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEN-DEDED 442
                QH+       + LL        Q Q   EQ+ +G +L + LV+KL  EN +  ++
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTGIAYYQRQRFCEQMVQGSQLTEILVRKLVTENHNGKKN 180

Query: 443 EDVQ 446
           ED Q
Sbjct: 181 EDRQ 184



 Score =  108 bits (270), Expect = 3e-23
 Identities = 72/184 (39%), Positives = 103/184 (55%), Gaps = 9/184 (4%)

Query: 1   MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGF-LANRQKKYK 59
           M VSA      +AE +ILE N+ LR +L + KQ F++L EK   ++   + L N  +KYK
Sbjct: 1   MAVSATTCFGPRAEISILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60

Query: 60  YEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 119
            EECKDLI+ +L  E QF+E +LAE  + A  LR +  L+ +Q  ELT LR+K +EGR  
Sbjct: 61  CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKTQEGRGV 120

Query: 120 SRSLNQHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEN-DEDED 171
                QH+       + LL        Q Q   EQ+ +G +L + LV+KL  EN +  ++
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTGIAYYQRQRFCEQMVQGSQLTEILVRKLVTENHNGKKN 180

Query: 172 EDVQ 175
           ED Q
Sbjct: 181 EDRQ 184


>gi|157311604 phosphodiesterase 4D interacting protein isoform 1 [Homo
            sapiens]
          Length = 2346

 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 73/244 (29%), Positives = 124/244 (50%), Gaps = 24/244 (9%)

Query: 332  EECEDLIKSMLRNERQFK----EEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREG 387
            ++ E LI+ + + E Q      EEKLAE+L+ A    +Y  L+  Q REL+ LR+K+REG
Sbjct: 1436 KDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREG 1495

Query: 388  RDASRSLNQH-------LQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDED 440
            R     + +H        + LL  ++ D   GQ  +EQLA+G +L + L  KLS ++ + 
Sbjct: 1496 RGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKS 1555

Query: 441  EDEDVQVEEAEKVLESSAPREVQKAEE-SKVPEDSLEECAITCSNSHGPCDSNQPHKNIN 499
            E +   +E     L     RE+Q+ E+  +V +  L+  ++T S+SH   DS++   + +
Sbjct: 1556 EKDQAGLEP----LALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTS 1611

Query: 500  ITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSE-----K 554
               +E +  S + +  E +H E + A    P    +   ++ S V+S+ P S+      K
Sbjct: 1612 FLSDELEACSDMDIVSEYTHYEEKKA---SPSHSDSIHHSSHSAVLSSKPSSTSASQGAK 1668

Query: 555  AEMN 558
            AE N
Sbjct: 1669 AESN 1672



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 68/222 (30%), Positives = 114/222 (51%), Gaps = 20/222 (9%)

Query: 79   EEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQH-------LQALL 131
            EEKLAE+L+ A    +Y  L+  Q REL+ LR+K+REGR     + +H        + LL
Sbjct: 1458 EEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLL 1517

Query: 132  TPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREV 191
              ++ D   GQ  +EQLA+G +L + L  KLS ++ + E +   +E     L     RE+
Sbjct: 1518 RSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEP----LALRLSREL 1573

Query: 192  QKAEE-SKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDE 250
            Q+ E+  +V +  L+  ++T S+SH   DS++   + +   +E +  S + +  E +H E
Sbjct: 1574 QEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYE 1633

Query: 251  CQDAVNILPVPGPTSSATNVSMVVSAGPLSSE-----KAEMN 287
             + A    P    +   ++ S V+S+ P S+      KAE N
Sbjct: 1634 EKKA---SPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESN 1672



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 75/273 (27%), Positives = 129/273 (47%), Gaps = 24/273 (8%)

Query: 603  EECKDLIKSVLRNERQFK----EEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREG 658
            ++ + LI+ V + E Q      EEKLAE+L+ A    +Y  L+  Q REL+ LR+K+REG
Sbjct: 1436 KDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREG 1495

Query: 659  RDASRSLNQH-------LQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDND 711
            R     + +H        + LL  ++ D   GQ  +EQLA+G +L ++L  KLS ++   
Sbjct: 1496 RGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKS 1555

Query: 712  HDEDVQVE-VAEKVQKSSAPREMQKAEEK-EVPEDSLEECAITCSNSHGPYDSNQPHRKT 769
              +   +E +A ++      RE+Q+ E+  EV +  L+  ++T S+SH   DS++    T
Sbjct: 1556 EKDQAGLEPLALRLS-----RELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSST 1610

Query: 770  KITFEEDKV--DSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEV 827
                +E +   D  ++   +H E + A    P +            +S +    S  +  
Sbjct: 1611 SFLSDELEACSDMDIVSEYTHYEEKKA---SPSHSDSIHHSSHSAVLSSKPSSTSASQGA 1667

Query: 828  PQESWDEGYSTLSIPPEMLASYQSYSG-TFHSL 859
              ES     S  +       + Q++SG  FHS+
Sbjct: 1668 KAESNSNPISLPTPQNTPKEANQAHSGFHFHSI 1700



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 143/686 (20%), Positives = 256/686 (37%), Gaps = 140/686 (20%)

Query: 355  EQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQD 414
            E L    E  Q+       E EL +L+ ++ E   +S S  ++    L        +  +
Sbjct: 1005 EMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLC------LENAE 1058

Query: 415  LQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEA---EKVLESSAPREVQKAEESKVP 471
            L+EQ+ E       +      E D+++ E V VE     E + ESS   E +K +     
Sbjct: 1059 LKEQMGEAMSDGWEI------EEDKEKGE-VMVETVVTKEGLSESSLQAEFRKLQGKLKN 1111

Query: 472  EDSL-----EECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAV 526
              ++     E+  ++    +       P   +++T   +++N+ LV        + +  V
Sbjct: 1112 AHNIINLLKEQLVLSSKEGNSKLT---PELLVHLTSTIERINTELVGSPGKHQHQEEGNV 1168

Query: 527  NILPVPGPTSSATNVSMVVSAGPLSSE--------KAEMNILEMNEKLRPQLAEKKQQFR 578
             + P P P S     +  V A  L ++        ++  ++    + LR QL++ KQ+++
Sbjct: 1169 TVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQ 1228

Query: 579  NLKEKCFVTQLACFL-ANQQNKYK------------------------YEECKDLIKSVL 613
            +L+EK  +++   F  AN+  KY+                        YE C        
Sbjct: 1229 DLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAE 1288

Query: 614  RNERQFKEEKLAEQLKQ--------AEELRQYKVLVHSQERE------------------ 647
            R E    E +    LK+        +E+ R+   L  S ER+                  
Sbjct: 1289 REETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKS 1348

Query: 648  --LTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRL-AQQLFQKL 704
              +  LR+ +++ +   ++ N+ +Q L +      S   D    L    +L A    +  
Sbjct: 1349 ENILVLRKDIKDLKAQLQNANKVIQNLKSRVR-SLSVTSDYSSSLERPWKLRAVGTLEGS 1407

Query: 705  SPENDNDHDEDVQVE----------VAEKVQKSSAPREMQKAEEKEVPEDSLEEC---AI 751
            SP +  D DE    +           A+K  +S   R  Q   E ++P++ LEE     +
Sbjct: 1408 SPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQL--EAQLPKNGLEEKLAEEL 1465

Query: 752  TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEK 811
              ++  G YDS    +  ++++   K+           E     ++I  +  D  +  E 
Sbjct: 1466 RSASWPGKYDSLIQDQARELSYLRQKIR----------EGRGICYLITRHAKDTVKSFED 1515

Query: 812  GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIG 871
                   L+ ++ +    +S+ E  +  S   E L S    S   H  E+ Q  +     
Sbjct: 1516 ------LLRSNDIDYYLGQSFREQLAQGSQLTERLTS--KLSTKDHKSEKDQAGL----- 1562

Query: 872  GHRWDQVKKEDQEATGPRLSRELLD-EKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSA 930
                        E    RLSREL + EK  EVLQ  LD    TPS    L+DS +   S 
Sbjct: 1563 ------------EPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSST 1610

Query: 931  FYILEQQRVGWALDMDEIEKYQEVEE 956
             ++ ++       DMD + +Y   EE
Sbjct: 1611 SFLSDELEA--CSDMDIVSEYTHYEE 1634



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 91/429 (21%), Positives = 170/429 (39%), Gaps = 61/429 (14%)

Query: 84   EQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQD 143
            E L    E  Q+       E EL +L+ ++ E   +S S  ++    L        +  +
Sbjct: 1005 EMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLC------LENAE 1058

Query: 144  LQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEA---EKVLESSAPREVQKAEESKVP 200
            L+EQ+ E       +      E D+++ E V VE     E + ESS   E +K +     
Sbjct: 1059 LKEQMGEAMSDGWEI------EEDKEKGE-VMVETVVTKEGLSESSLQAEFRKLQGKLKN 1111

Query: 201  EDSL-----EECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQDAV 255
              ++     E+  ++    +       P   +++T   +++N+ LV        + +  V
Sbjct: 1112 AHNIINLLKEQLVLSSKEGNSKLT---PELLVHLTSTIERINTELVGSPGKHQHQEEGNV 1168

Query: 256  NILPVPGPTSSATNVSMVVSAGPLSSE--------KAEMNILEMNEKLRPQLAEKKQQFR 307
             + P P P S     +  V A  L ++        ++  ++    + LR QL++ KQ+++
Sbjct: 1169 TVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQ 1228

Query: 308  NLKEKCFVTQLAGFL-ANQQNKYKYEECEDLIKSMLRNERQFKEEKL-------AEQLKQ 359
            +L+EK  +++   F  AN+  KY+     + +      + Q   + L       +E   +
Sbjct: 1229 DLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAE 1288

Query: 360  AEELRQYKVLVHSQERELTQLR----EKLREGRD-ASRSLNQHLQALLTPDEPDKSQG-- 412
             EE    +   H+  +E+  +     E+ R G   AS S  + L+  L   E  +  G  
Sbjct: 1289 REETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKS 1348

Query: 413  ----------QDLQEQLAEGCRLAQHL---VQKLSPENDEDED-EDVQVEEAEKVLESSA 458
                      +DL+ QL    ++ Q+L   V+ LS  +D     E      A   LE S+
Sbjct: 1349 ENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSS 1408

Query: 459  PREVQKAEE 467
            P  V   +E
Sbjct: 1409 PHSVPDEDE 1417



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 132/688 (19%), Positives = 261/688 (37%), Gaps = 136/688 (19%)

Query: 69  FMLRNERQFKEEKLAEQLKQAEE-----LRQYKVLVHSQERELTQLREKLREGRDASRSL 123
           F L+    F EE++ ++ + + E       + KV V S +REL   ++ L +      +L
Sbjct: 20  FSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENL 79

Query: 124 NQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVL 183
           N   +A L      + Q ++ Q++      L ++ +Q L  E+   ++E  ++     ++
Sbjct: 80  NSQNEAEL------RRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAA---LV 130

Query: 184 ESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDK----VNST 239
           E+     ++ +E+ K    + E+          P D  +P +      + DK    +N +
Sbjct: 131 EAEKECNLELSEKLKGVTKNWEDV---------PGDQVKPDQYTEALAQRDKRIEELNQS 181

Query: 240 LVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQL 299
           L           ++   +L                    L  E   M +  M E+L    
Sbjct: 182 LAAQERLVEQLSREKQQLLH-------------------LLEEPTSMEVQPMTEELL--- 219

Query: 300 AEKKQQFRNLKEKCFVTQLAG--FLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQL 357
              KQQ  N  E     Q      LA  Q K +  E  + I     NE  + E K A++ 
Sbjct: 220 ---KQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSY-ELKCAQES 275

Query: 358 KQAEE--LRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDL 415
            Q ++  ++  K  + S+ERE  +L + +    D    L + L            Q Q  
Sbjct: 276 SQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLH-----------QSQLG 324

Query: 416 QEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSL 475
           Q   +EG   AQ  V  L  ++     + +++++ ++V+        QK  +    +  +
Sbjct: 325 QLHSSEGTSPAQQQVALLDLQSALFCSQ-LEIQKLQRVVR-------QKERQLADAKQCV 376

Query: 476 EECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPT 535
           +        S    +++  H            N  L    +   +E Q            
Sbjct: 377 QFVEAAAHESEQQKEASWKH------------NQELRKALQQLQEELQ------------ 412

Query: 536 SSATNVSMVVSAGPLSSEKAEMNILEMN-EKLRPQLAEKKQQFRNLKEKCFVTQLACFLA 594
               N S  + A   + +  E+   E N + L   L+ K+Q  +  +E          L 
Sbjct: 413 ----NKSQQLRAWE-AEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRE---------LLQ 458

Query: 595 NQQNKYKYEECKDLIKSVLRNERQFK--------EEKLAEQLKQAEELRQYKVLVHSQER 646
            + N  K  E  +++   LR     K        +EK +   ++ +ELRQ ++ V  ++ 
Sbjct: 459 YRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDH 518

Query: 647 ELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSP 706
           +L    E+LR+   ++ +  Q +++LL      +++G ++ EQL+  C+  Q L +++  
Sbjct: 519 DL----ERLRDVLSSNEATMQSMESLL------RAKGLEV-EQLSTTCQNLQWLKEEMET 567

Query: 707 ENDNDHDEDVQVEVAEKVQKSSAPREMQ 734
           +      E  Q  + +++Q S   R  +
Sbjct: 568 KFSRWQKE--QESIIQQLQTSLHDRNKE 593



 Score = 38.9 bits (89), Expect = 0.030
 Identities = 143/755 (18%), Positives = 284/755 (37%), Gaps = 145/755 (19%)

Query: 8    WSSEK------AETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKYE 61
            W +EK       E NI  +N  L  +  +  Q+FR L            L  R    K  
Sbjct: 421  WEAEKYNEIRTQEQNIQHLNHSLSHK-EQLLQEFREL------------LQYRDNSDKTL 467

Query: 62   ECKDLIKFMLRNERQFK--------EEKLAEQLKQAEELRQYKVLVHSQERELTQLREKL 113
            E  +++   LR     K        +EK +   ++ +ELRQ ++ V  ++ +L +LR+ L
Sbjct: 468  EANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVL 527

Query: 114  REGRDASRSLN-----------------QHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQ 156
                   +S+                  Q+LQ L    E   S+ Q  QE + +  + + 
Sbjct: 528  SSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSL 587

Query: 157  H------------LVQKLSPENDED-------------------EDEDVQVEEAEKVLES 185
            H            L+ KL P   E                     D + QV E E  ++ 
Sbjct: 588  HDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQG 647

Query: 186  SAPREVQKAEESKVPEDSLEECAITCSNSH--------GPCDSNQPHKNINITFEEDKVN 237
                   + +ES+   + L + A+   NS         G  DS        I+ ++ +V 
Sbjct: 648  LLQSVSTREQESQAAAEKLVQ-ALMERNSELQALRQYLGGRDSLM--SQAPISNQQAEVT 704

Query: 238  STLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRP 297
             T  + +++     Q       +P    S +    + +   +S  ++ +  L+    L  
Sbjct: 705  PTGCLGKQTDQGSMQ-------IPSRDDSTS----LTAKEDVSIPRSTLGDLDTVAGLEK 753

Query: 298  QLAEKKQQFRNLKEK-----CFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEK 352
            +L+  K++   + +K       ++ L   +A Q+ + + +  +  ++S+ RN  Q KE+ 
Sbjct: 754  ELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAAD--MESLTRN-IQIKEDL 810

Query: 353  LAE---QLKQAEELRQYKVLVHSQERELTQLREKL----REGRDASRSLNQHLQALLTPD 405
            + +   QL   E++   + L     +E+  LREK+     +G++ S +  Q L  +L   
Sbjct: 811  IKDLQMQLVDPEDIPAMERLT----QEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL 866

Query: 406  EPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVE-EAEKVLESSAPREVQK 464
              ++S+   L E L    +L   LV+  +     + D  +QVE E  +VL S     + +
Sbjct: 867  VDERSR---LNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGR 923

Query: 465  AEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQD 524
            + E     + LE  A     + G   +    ++ +  F +        ++ E++H   Q 
Sbjct: 924  SLERL---NRLETLA-----AIGGAAAGDDTEDTSTEFTDS-------IEEEAAHHSHQQ 968

Query: 525  AVNILPVPGPTSSATNVSMVVSAGPL---SSEKAEMNILEMNEKLRPQLAEKKQQFRNLK 581
             V +       +  T         P+   S+   +  +L +  +    L EK++    LK
Sbjct: 969  LVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELK 1028

Query: 582  EKCFVTQLACFLANQQNK-------YKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEEL 634
            E     + A F +    +        +  E K+ +   + +  + +E+K   ++     +
Sbjct: 1029 ELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVV 1088

Query: 635  RQYKVLVHSQERELTQLREKLREGRDASRSLNQHL 669
             +  +   S + E  +L+ KL+   +    L + L
Sbjct: 1089 TKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQL 1123



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 101/522 (19%), Positives = 198/522 (37%), Gaps = 83/522 (15%)

Query: 289 LEMNEKLRPQLAEKKQQFRNLKE-----------------------KCFVTQLA---GFL 322
           L   E+L  QL+ +KQQ  +L E                       +  +TQ +     L
Sbjct: 182 LAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHL 241

Query: 323 ANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEE--LRQYKVLVHSQERELTQL 380
           A  Q K +  E  + I     NE  + E K A++  Q ++  ++  K  + S+ERE  +L
Sbjct: 242 AELQEKIQQTEATNKILQEKLNEMSY-ELKCAQESSQKQDGTIQNLKETLKSRERETEEL 300

Query: 381 REKLREGRDASRSLNQ-----HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP 435
            + +    D    L +      L  L + +    +Q Q     L      +Q  +QKL  
Sbjct: 301 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 360

Query: 436 ENDEDEDEDVQVEEAEKVLESSAPREVQKAEES----KVPEDSLEECAITCSNSHGPCDS 491
              + E +    ++  + +E++A    Q+ E S    +    +L++      N      +
Sbjct: 361 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 420

Query: 492 NQPHKNINITFEEDKVNSALVVDRESSHDE--CQDAVNILPVPGPTSSATNVSMVVSAGP 549
            +  K   I  +E  +     ++   SH E   Q+   +L          N    + A  
Sbjct: 421 WEAEKYNEIRTQEQNIQH---LNHSLSHKEQLLQEFRELL------QYRDNSDKTLEANE 471

Query: 550 LSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEK-CFVTQLACFLANQQNKYKYEECKDL 608
           +  EK    I +    L   + EK   F  L+EK   + QL   LA ++  +  E  +D+
Sbjct: 472 MLLEKLRQRIHDKAVALERAIDEK---FSALEEKEKELRQLR--LAVRERDHDLERLRDV 526

Query: 609 IKS---------VLRNERQFKEEKLAEQLKQAEELRQ-----YKVLVHSQERELTQLREK 654
           + S          L   +  + E+L+   +  + L++     +      QE  + QL+  
Sbjct: 527 LSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTS 586

Query: 655 LREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDN---D 711
           L +       L+  L   L P +       ++ E+L +  +  +++ Q L  + +    +
Sbjct: 587 LHDRNKEVEDLSATLLCKLGPGQ------SEIAEELCQRLQRKERMLQDLLSDRNKQVLE 640

Query: 712 HDEDVQ-----VEVAEKVQKSSAPREMQKAEEKEVPEDSLEE 748
           H+ ++Q     V   E+  +++A + +Q   E+     +L +
Sbjct: 641 HEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQ 682



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 32/91 (35%), Positives = 43/91 (47%), Gaps = 6/91 (6%)

Query: 950  KYQEVEEDQ---DPSCPRLSRELLD-EKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSA 1005
            K  + E+DQ   +P   RLSREL + EK  EVLQ  LD    TPS    L D  +   S 
Sbjct: 1551 KDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSST 1610

Query: 1006 VYSLEEQYLGLALDVDRIKKDQEEEEDQGPP 1036
             +  +E  L    D+D + +    EE +  P
Sbjct: 1611 SFLSDE--LEACSDMDIVSEYTHYEEKKASP 1639



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 28/75 (37%), Positives = 36/75 (48%), Gaps = 4/75 (5%)

Query: 1025 KDQEEEEDQG---PPCPRLSRELLEAVEP-EVLQDSLDRCYSTPSSCLEQPDSCLPYGSS 1080
            KD + E+DQ    P   RLSREL E  +  EVLQ  LD    TPSS     DS     S+
Sbjct: 1551 KDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSST 1610

Query: 1081 FYALEEKHVGFSLDV 1095
             +  +E      +D+
Sbjct: 1611 SFLSDELEACSDMDI 1625



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 82/401 (20%), Positives = 159/401 (39%), Gaps = 62/401 (15%)

Query: 18  LEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKYEECKDLIKFM------L 71
           LEI +KL+  + + ++Q  + K+     + A   + +QK+  ++  ++L K +      L
Sbjct: 353 LEI-QKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEEL 411

Query: 72  RNE----RQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKL--REGRDASRSLNQ 125
           +N+    R ++ EK  E   Q + ++     +  +E+ L + RE L  R+  D +   N+
Sbjct: 412 QNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANE 471

Query: 126 HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLES 185
            L   L     DK+    L+  + E     +   ++L        + D  +E    VL S
Sbjct: 472 MLLEKLRQRIHDKAVA--LERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSS 529

Query: 186 SAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRE 245
           +           +     +E+ + TC N           K      E++ +   L     
Sbjct: 530 NEATMQSMESLLRAKGLEVEQLSTTCQNLQW-LKEEMETKFSRWQKEQESIIQQLQTSLH 588

Query: 246 SSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQ 305
             + E +D               + +++   GP  SE A        E+L  +L  K++ 
Sbjct: 589 DRNKEVED--------------LSATLLCKLGPGQSEIA--------EELCQRLQRKERM 626

Query: 306 FRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQ 365
            ++L              N+Q      E + L++S+  + R+ + +  AE+L QA     
Sbjct: 627 LQDLLSD----------RNKQVLEHEMEIQGLLQSV--STREQESQAAAEKLVQA----- 669

Query: 366 YKVLVHSQERELTQLREKLREGRDA--SRSLNQHLQALLTP 404
               +  +  EL  LR+ L  GRD+  S++   + QA +TP
Sbjct: 670 ----LMERNSELQALRQYL-GGRDSLMSQAPISNQQAEVTP 705



 Score = 31.6 bits (70), Expect = 4.8
 Identities = 34/103 (33%), Positives = 48/103 (46%), Gaps = 10/103 (9%)

Query: 90   EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 149
            E+ R+ +  +    RE +Q  E LRE   +SRS   HLQ L    E  K + Q L E L 
Sbjct: 1909 EDNRRLQAQLSHVSREHSQETESLREALLSSRS---HLQELEKELEHQKVERQQLLEDLR 1965

Query: 150  EGCRLAQHL-VQKLS-PENDEDEDEDV-----QVEEAEKVLES 185
            E  +   H   ++LS  END      +     Q EE +++ ES
Sbjct: 1966 EKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFES 2008



 Score = 31.6 bits (70), Expect = 4.8
 Identities = 34/103 (33%), Positives = 48/103 (46%), Gaps = 10/103 (9%)

Query: 361  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420
            E+ R+ +  +    RE +Q  E LRE   +SRS   HLQ L    E  K + Q L E L 
Sbjct: 1909 EDNRRLQAQLSHVSREHSQETESLREALLSSRS---HLQELEKELEHQKVERQQLLEDLR 1965

Query: 421  EGCRLAQHL-VQKLS-PENDEDEDEDV-----QVEEAEKVLES 456
            E  +   H   ++LS  END      +     Q EE +++ ES
Sbjct: 1966 EKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFES 2008



 Score = 30.8 bits (68), Expect = 8.2
 Identities = 49/204 (24%), Positives = 86/204 (42%), Gaps = 29/204 (14%)

Query: 22   EKLRPQLAENKQQFRNLKEKCFVTQLAGFL-ANRQKKYKYEECKDLIKFMLRNERQFKEE 80
            + LR QL++ KQ++++L+EK  +++   F  AN  +KY+     + +      + Q   +
Sbjct: 1214 QHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQ 1273

Query: 81   KL-------AEQLKQAEELRQYKVLVHSQERELTQLR----EKLREGRD-ASRSLNQHLQ 128
             L       +E   + EE    +   H+  +E+  +     E+ R G   AS S  + L+
Sbjct: 1274 DLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLE 1333

Query: 129  ALLTPDEPDKSQG------------QDLQEQLAEGCRLAQHL---VQKLSPENDEDED-E 172
              L   E  +  G            +DL+ QL    ++ Q+L   V+ LS  +D     E
Sbjct: 1334 NQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLE 1393

Query: 173  DVQVEEAEKVLESSAPREVQKAEE 196
                  A   LE S+P  V   +E
Sbjct: 1394 RPWKLRAVGTLEGSSPHSVPDEDE 1417


>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
          Length = 1154

 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 184/860 (21%), Positives = 336/860 (39%), Gaps = 123/860 (14%)

Query: 27   QLAENKQQFRNLKEKCFVTQLAGFLAN----RQKKYKYEECKDLIKFMLRNERQFKEEKL 82
            Q++E +Q+    + KC   ++  F  +    + ++ K   C    K+    + Q   E L
Sbjct: 332  QVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQ--NELL 389

Query: 83   AEQLKQAEELRQYKV----LVHSQ-ERELTQLREKLREGRDASRSLNQHLQALLTPDEPD 137
              QL+   ELRQ KV    LV +Q E+EL    +KL            HLQ      E +
Sbjct: 390  KMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKL------------HLQHQNVTCEKE 437

Query: 138  K--SQGQDLQEQLAEGCRLAQHL---VQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQ 192
            K   + Q LQE+L       QHL   V      N++D +   Q++E +++ ++S      
Sbjct: 438  KLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASK----D 493

Query: 193  KAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQ 252
            + E  K   D LE+  + C                 +  +E K +  +  D+    ++C 
Sbjct: 494  ELERQKHMYDQLEQDLLLCQ----------------LELKELKASHPIPEDKGKCANKCD 537

Query: 253  DAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEK 312
              ++ L        A+   M    G L  E+ E+  LE   +++ +  + +++   L   
Sbjct: 538  TLLSRLTELQEKYKASQKEM----GQLQMEQCEL--LEDQRRMQEEQGQLQEELHRLT-- 589

Query: 313  CFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEK---------LAEQLKQAEEL 363
                  +G L   Q      + EDL +  L  +   +E+K         L EQL+  EEL
Sbjct: 590  -LPLPKSGLLLKSQELLT--KLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEEL 646

Query: 364  RQYK------VLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE 417
            R++K      VL +  + +L +  +  R  +  S+ L + +QAL    +  +++ + LQ+
Sbjct: 647  RRFKESHFQEVLENPDDSKLAKSSKCNRNKQ--SKLLMEQMQALQVMYDAGQAKQELLQQ 704

Query: 418  QLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEE 477
            +        + L   L    +E +   VQ    +  LES       K+  S VP +  E 
Sbjct: 705  EQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYG-----KSYGSMVPSN--EN 757

Query: 478  CAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSS 537
            C  T   +    D N+ +   + T  +    S L      S+D    A         T+S
Sbjct: 758  CRKTYDTT---VDDNESYYK-SYTSTQTSSKSFL-----KSYDSSTSASEAYGKSYCTTS 808

Query: 538  ATNVSMVVSAGPLSS-EKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQ 596
             ++++   S G  SS +  + + +       P   E  ++F  +  K  +   A     Q
Sbjct: 809  NSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQ 868

Query: 597  QNKYKYEECKDLIKSVLRNERQFKEEKLA--EQLKQAEELRQYKVLVHSQERELTQLREK 654
             ++ ++ + ++ ++ +L  ++  KEE  A   + K+  E  +  +   + + E+ +L+ K
Sbjct: 869  ISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTK 928

Query: 655  LREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDE 714
            LRE +   ++       LL   E  + Q Q  QE+L +       + ++   +N N +  
Sbjct: 929  LRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMN 988

Query: 715  DVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 774
                + A  V+     +      E ++      E  +    S    D      + K   E
Sbjct: 989  ----KNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEME 1044

Query: 775  EDKVD----------STLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEE 824
            E+K              L+   +  E   +     ENE D EEEE++        ++SEE
Sbjct: 1045 EEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKE--------EDSEE 1096

Query: 825  EEVPQESWDEGYSTLSIPPE 844
            EE      D+  S+L  P E
Sbjct: 1097 EE------DDADSSLESPEE 1110



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 113/583 (19%), Positives = 223/583 (38%), Gaps = 87/583 (14%)

Query: 19   EINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFK 78
            E+ E  R    E  Q    L         +G L   Q+     + +DL +  L  +   +
Sbjct: 566  ELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLT--KLEDLCELQLLYQGMQE 623

Query: 79   EEK---------LAEQLKQAEELRQYK------VLVHSQERELTQLREKLREGRDASRSL 123
            E+K         L EQL+  EELR++K      VL +  + +L +  +  R  +  S+ L
Sbjct: 624  EQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQ--SKLL 681

Query: 124  NQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVL 183
             + +QAL    +  +++ + LQ++        + L   L    +E +   VQ    +  L
Sbjct: 682  MEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSL 741

Query: 184  ESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVD 243
            ES       K+  S VP +  E C  T   +    D N+ +   + T  +    S L   
Sbjct: 742  ESYG-----KSYGSMVPSN--ENCRKTYDTT---VDDNESYYK-SYTSTQTSSKSFL--- 787

Query: 244  RESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSS-EKAEMNILEMNEKLRPQLAEK 302
               S+D    A         T+S ++++   S G  SS +  + + +       P   E 
Sbjct: 788  --KSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPED 845

Query: 303  KQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLA--EQLKQA 360
             ++F  +  K  +   A     Q ++ ++ + ++ ++ +L  ++  KEE  A   + K+ 
Sbjct: 846  MERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKEC 905

Query: 361  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQL- 419
             E  +  +   + + E+ +L+ KLRE +   ++       LL   E  + Q Q  QE+L 
Sbjct: 906  MECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELR 965

Query: 420  ------------AEGCRLAQHL--------VQKLSPENDEDEDEDVQVEEAEKVL----- 454
                        A G    +++        ++K++    +  + D++  ++ +V+     
Sbjct: 966  QLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKA 1025

Query: 455  ---------ESSAPREVQKAEESKVPEDSLEECA--------------ITCSNSHGPCDS 491
                     +    +E  + E+ +V E++ E+C                T        D 
Sbjct: 1026 SQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDK 1085

Query: 492  NQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGP 534
             +  K  +   EED  +S+L    E++     ++    P P P
Sbjct: 1086 EEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNP 1128



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 106/606 (17%), Positives = 229/606 (37%), Gaps = 59/606 (9%)

Query: 158 LVQKLSPENDEDEDEDVQVEEAEKVLE---SSAPREVQKAEESKVPEDSLEECAITCSNS 214
           L+  L  E +E+E+E+ +VEE E+ ++   S     V K     + E  LEE        
Sbjct: 9   LLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQL 68

Query: 215 HGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVV 274
               +     + +    E+D +    +++ E      Q  V    +        ++   +
Sbjct: 69  VAELEET---RELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEI 125

Query: 275 SAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYE-E 333
           S   L   + E  + E+ ++L    AE  Q  R   E       +   + Q++  + + E
Sbjct: 126 S---LLEHEKESELKEIEQELHLAQAEI-QSLRQAAEDSATEHESDIASLQEDLCRMQNE 181

Query: 334 CEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRS 393
            ED+ +     E +    +   ++K +E      +  +S       L+E+L+E R+    
Sbjct: 182 LEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSG------LQEELQELRERYHF 235

Query: 394 LNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKV 453
           LN+  +AL   +     Q  DL+ +  +         Q LS  + E +  ++   E +  
Sbjct: 236 LNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPE 295

Query: 454 LESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEED-------K 506
           ++    ++++ AEE         +C   C      C+  +   +  ++ EE        K
Sbjct: 296 MQ-LLRQQLRDAEEQM--HGMKNKCQELC------CELEELQHHRQVSEEEQRRLQRELK 346

Query: 507 VNSALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKL 566
                V+  ++SH   Q+               +    +     +S+  +  +L+M  +L
Sbjct: 347 CAQNEVLRFQTSHSVTQN-----------EELKSRLCTLQKKYDTSQDEQNELLKMQLQL 395

Query: 567 RPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAE 626
           + +L + K     L E     +L C L     +++   C+             KE+ L  
Sbjct: 396 QTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCE-------------KEKLLER 442

Query: 627 QLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDL 686
           Q +  EEL+ ++  +      +   +E   +  +    L Q ++ L    + +  + + +
Sbjct: 443 QQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQL-QEMKQLYQASKDELERQKHM 501

Query: 687 QEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEK-VQKSSAPREMQKAEEKEVPEDS 745
            +QL +   L Q   ++L   +    D+       +  + + +  +E  KA +KE+ +  
Sbjct: 502 YDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQ 561

Query: 746 LEECAI 751
           +E+C +
Sbjct: 562 MEQCEL 567



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 67/293 (22%), Positives = 123/293 (41%), Gaps = 39/293 (13%)

Query: 5    AGPWSSEKAETNILEINEKLRPQLA------ENKQQFRNLKEKCFVTQ--LAGFLANRQK 56
            A P   E+ E  ++++  KL+   A      E   Q +   EK    Q  L   L   ++
Sbjct: 841  AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER 900

Query: 57   KYKYEECKDLIKFML-----RNERQFKEEKLAE-QLK-QAEELRQYKVLVHSQE------ 103
            ++K  EC + ++  +     +NE +  + KL E QL+ QA    Q ++LV  ++      
Sbjct: 901  EFK--ECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQ 958

Query: 104  ---RELTQLREKL------REGRDASRSLNQHLQAL----LTPDEPDKSQGQDLQEQLAE 150
                EL QLREK         G++A++++N++   +    +T    D S+  DL+ + + 
Sbjct: 959  CCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSES-DLETRKSL 1017

Query: 151  GCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAIT 210
               L     Q+      ++E++  ++EE +K ++  A    Q  +E        EE   T
Sbjct: 1018 EVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKE--QCGDELVAEPADPEEAKST 1075

Query: 211  CSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGP 263
                    D  +  K  +   EED  +S+L    E++     ++    P P P
Sbjct: 1076 EDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNP 1128


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 211/973 (21%), Positives = 386/973 (39%), Gaps = 142/973 (14%)

Query: 99   VHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQG----QDLQEQLAEGCRL 154
            V S   +L Q   K ++ RD  R   Q L+  LT  E +KSQ     QDLQ QL++    
Sbjct: 1241 VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQN--- 1297

Query: 155  AQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR-EVQKAEESKVPEDSLEECAITCSN 213
             Q    K   + +  E E +++ E    L+S   R E+Q+ E                  
Sbjct: 1298 -QEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME------------------ 1338

Query: 214  SHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMV 273
            + G  +  Q  K  N+T + + + + +V  R  +      A  IL     T+        
Sbjct: 1339 AQGERELLQAAKE-NLTAQVEHLQAAVVEARAQA-----SAAGILEEDLRTAR------- 1385

Query: 274  VSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEE 333
             SA  L +E+ E      +E+ R Q  +++ + +  + K     LA  L  Q    + EE
Sbjct: 1386 -SALKLKNEEVE------SERERAQALQEQGELKVAQGKALQENLA--LLTQTLAEREEE 1436

Query: 334  CEDLIKSMLRNERQFKE-EKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASR 392
             E L         Q +E EK  E  K A EL    +   +QE +L Q  E+++E  +  R
Sbjct: 1437 VETL-------RGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQ--EQIQE-LEKCR 1486

Query: 393  SLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEK 452
            S+ +HL   +          Q+ +++L       + L +    + +  E + +++E+ ++
Sbjct: 1487 SVLEHLPMAV----------QEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQ 1536

Query: 453  VLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPH-KNINITFEEDKVN-SA 510
            ++ES    +VQ  ++  V   +LE  A+    +H   +  Q   K +    E  +V  + 
Sbjct: 1537 MIESQRG-QVQDLKKQLV---TLECLALELEENHHKMECQQKLIKELEGQRETQRVALTH 1592

Query: 511  LVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILE-MNEKLRPQ 569
            L +D E    E Q   + +      S+     +      + S++ ++  L+   E L   
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD 1652

Query: 570  LAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSV------LRNERQFKEEK 623
            L  + Q+    KE+  V +       +Q K   E+ + +  S+      L  +RQ  +E+
Sbjct: 1653 LERRDQELMLQKERIQVLEDQ---RTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQER 1709

Query: 624  LAE----QLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL------- 672
              E       Q   L   K+++  +E+E+   +E + E ++    L Q LQ L       
Sbjct: 1710 AEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGET 1769

Query: 673  ---LTPDEPD-KSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSS 728
               L+  E +     Q LQE   +G    Q L  +L          D ++E  ++ Q+ +
Sbjct: 1770 SLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQA 1829

Query: 729  APREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSH 788
              +E +  E+ +  + +LE+  +T    HG     Q H++     EE+     L      
Sbjct: 1830 QGQEERVKEKADALQGALEQAHMTLKERHGEL---QDHKEQARRLEEE-----LAVEGRR 1881

Query: 789  VEWEDAVHIIPENESDDEEEEEKG--PVSPRNLQESEEEEVP----QESWDEGYSTLSIP 842
            V+   A+  +  +   +  E+EK    +  +  ++++E EV     Q+SW +  + L   
Sbjct: 1882 VQ---ALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKER 1938

Query: 843  PEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEV 902
             + L + ++ S +    EE     A  +            QEA G   +   L  K   +
Sbjct: 1939 DQELEALRAESQSSRHQEEAARARAEAL------------QEALGK--AHAALQGKEQHL 1984

Query: 903  L-QDSLDRCYSTPSGYLELT-DSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDP 960
            L Q  L R     +  L+ + D+CQ +  +  + E  R+      D+  +YQE  +    
Sbjct: 1985 LEQAELSRSLEASTATLQASLDACQAH--SRQLEEALRIQEGEIQDQDLRYQEDVQQLQQ 2042

Query: 961  SCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV 1020
            +  +   EL  ++E E L +         +   E  +LGQ         EE+  GL   V
Sbjct: 2043 ALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQERE------EEEIRGLHQSV 2096

Query: 1021 DRIKKDQEEEEDQ 1033
              ++    ++E +
Sbjct: 2097 RELQLTLAQKEQE 2109



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 203/1019 (19%), Positives = 380/1019 (37%), Gaps = 203/1019 (19%)

Query: 10   SEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQL-----AGFL------ANRQKKY 58
            +EK   ++LE   + + +LA+  QQ   L++   V +L      G L      A R+ K 
Sbjct: 923  TEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKE 982

Query: 59   KYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ-LREKLREGR 117
               + +D +  +        ++K+  Q KQ E+L+   V     +R + Q ++EKLRE +
Sbjct: 983  AARQHRDDLAALQEESSSLLQDKMDLQ-KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQ 1041

Query: 118  DASR--------------SLNQHLQALLTPDEPDKSQGQDLQE-----QLAEGCRLAQHL 158
            + +R              SL +  Q LL   E D  + Q+L       Q A+G +     
Sbjct: 1042 EYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSA 1101

Query: 159  VQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQK-------AEESKVPEDSLEECAITC 211
              +L  +  ++++ D   +EA+ + E  A    ++       A+E+K  +  L     T 
Sbjct: 1102 QMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQL-RLRSTE 1160

Query: 212  SNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDEC-------------------- 251
            S         QP        +   + S L   +++    C                    
Sbjct: 1161 SQLEALAAEQQPGNQAQAQAQLASLYSAL---QQALGSVCESRPELSGGGDSAPSVWGLE 1217

Query: 252  --QDAVNILPVPGPTSSATNVSMVVSA----------GPLSSEKAEMNILEMNEKLRPQL 299
              Q+    L   GP  +A +   V SA             + +     + ++ E+L    
Sbjct: 1218 PDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTE 1277

Query: 300  AEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSML----------------- 342
            AEK Q    L++     QL+    NQ+ K K+E  ++ ++S L                 
Sbjct: 1278 AEKSQVHTELQD--LQRQLS---QNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRA 1332

Query: 343  -------RNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLN 395
                   + ER+  +        Q E L+   V   +Q      L E LR  R A +  N
Sbjct: 1333 ELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKN 1392

Query: 396  QHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVE 448
            + +       QAL    E   +QG+ LQE LA        L Q L+   +E E    Q++
Sbjct: 1393 EEVESERERAQALQEQGELKVAQGKALQENLA-------LLTQTLAEREEEVETLRGQIQ 1445

Query: 449  EAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVN 508
            E EK       RE+QKA        +LE  ++               +N  +  +++++ 
Sbjct: 1446 ELEK------QREMQKA--------ALELLSLDLKK-----------RNQEVDLQQEQIQ 1480

Query: 509  SALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEK-AEMNILEMN---- 563
                       ++C+  +  LP+                  L  ++  + N+LE      
Sbjct: 1481 EL---------EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531

Query: 564  EKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEK 623
            EK    +  ++ Q ++LK++  +  L C     +  +   EC+  +   L  +R+ +   
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQ--LVTLECLALELEENHHKMECQQKLIKELEGQRETQRVA 1589

Query: 624  LA----EQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPD 679
            L     +  ++++EL+     +H  E   T L  +L+E     +S  + ++ L    E  
Sbjct: 1590 LTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKE-- 1647

Query: 680  KSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEK 739
                QDL+ +  E   L ++  Q L  E+       +  E  E+++ S   R  +   ++
Sbjct: 1648 -HLTQDLERRDQE-LMLQKERIQVL--EDQRTRQTKILEEDLEQIKLSLRERGRELTTQR 1703

Query: 740  EVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIP 799
            ++ ++  EE         G  +    H K  +  +E +V+            ++ +H + 
Sbjct: 1704 QLMQERAEEGKGPSKAQRGSLE----HMKLILRDKEKEVECQ----------QEHIHELQ 1749

Query: 800  ENESDDEEE-----EEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSG 854
            E +   E++      + G  S    Q  +E  V Q+   E      +  + L S      
Sbjct: 1750 ELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQS------ 1803

Query: 855  TFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYST 913
                L+E Q  +A        + +++E Q+A G     E + EK  + LQ +L++ + T
Sbjct: 1804 ---QLDEAQRALAQ--RDQELEALQQEQQQAQG---QEERVKEKA-DALQGALEQAHMT 1853



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 162/748 (21%), Positives = 295/748 (39%), Gaps = 116/748 (15%)

Query: 24   LRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKYEECKDLIKFM--LRNERQFKEEK 81
            +R  L   +Q  ++L+++    Q A  L  +Q     EE K L + +  L  ER     +
Sbjct: 391  VRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQ 450

Query: 82   LAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQG 141
              +   + + L + + L+     EL Q  E L +     R +N  LQ      + D +QG
Sbjct: 451  TVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQL-----QGDSAQG 505

Query: 142  Q--DLQEQLAEGCR---LAQHLVQKLSPENDEDEDEDVQVEEA--EKVLESSAPREVQ-- 192
            Q  + QE+L    R     Q ++  L  +  E   E + + EA     LE    R+ Q  
Sbjct: 506  QKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTE 565

Query: 193  ------KAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRES 246
                  +AE+S     S E    T               N  +  ++  +N  L+   E 
Sbjct: 566  VTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEE 625

Query: 247  SHDEC------QDAVNILPVPGPTSSATNVSMVVSAGPLSSE--KAEMNILEMNEKLRPQ 298
            +   C      + A N L V    +     ++      L ++  KAE    E+   LR  
Sbjct: 626  NQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDI 685

Query: 299  LAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLK 358
              EK++  + L E                               R++++    +L EQL 
Sbjct: 686  QEEKEEIQKKLSES------------------------------RHQQEAATTQL-EQLH 714

Query: 359  QAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQ 418
            Q E  RQ +VL  + + +   +REK         +L   LQA+    E D+   QDL EQ
Sbjct: 715  Q-EAKRQEEVLARAVQEKEALVREK--------AALEVRLQAV----ERDR---QDLAEQ 758

Query: 419  LAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEEC 478
            L +G   A+ L++  S    + ++  ++V + +  ++     + ++  + +V    LE  
Sbjct: 759  L-QGLSSAKELLES-SLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE-- 814

Query: 479  AITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSA 538
             +    S    + +   + +    +E K     +  ++++H++    VN L        +
Sbjct: 815  -LDTERSQAEQERDAAARQLAQAEQEGK---TALEQQKAAHEK---EVNQLREKWEKERS 867

Query: 539  TNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQ-QFRNLKEKCFVTQLACFLANQQ 597
             +   +  A     E  E   +E+  +L+ Q  E +  Q +  +E+       C +  + 
Sbjct: 868  WHQQELAKA----LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLET 923

Query: 598  NKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQEREL-----TQLR 652
             K    E   L++++L+ +++     LA+  +Q E LRQ   +   +E+E      TQL+
Sbjct: 924  EK----ERVSLLETLLQTQKE-----LADASQQLERLRQDMKVQKLKEQETTGILQTQLQ 974

Query: 653  EKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDH 712
            E  RE ++A+R     L AL            DLQ+Q+ +   L  QL  +      +D 
Sbjct: 975  EAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVED---LKSQLVAQ------DDS 1025

Query: 713  DEDVQVEVAEKVQKSSAPREMQKAEEKE 740
               V+ EV EK++++     +QK  E+E
Sbjct: 1026 QRLVEQEVQEKLRETQEYNRIQKELERE 1053



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 141/741 (19%), Positives = 286/741 (38%), Gaps = 125/741 (16%)

Query: 24   LRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKYEECKDLIK-FMLRNER-QFKEEK 81
            L  +L E  Q+ ++ +E+    Q       RQK++  ++ +   +  ML+ ER Q  E++
Sbjct: 1621 LARELQERDQEVKSQREQIEELQ-------RQKEHLTQDLERRDQELMLQKERIQVLEDQ 1673

Query: 82   LAEQLKQAEE-LRQYKVLVHSQERELTQLREKLREGRD-------ASRSLNQHLQALLTP 133
               Q K  EE L Q K+ +  + RELT  R+ ++E  +       A R   +H++ +L  
Sbjct: 1674 RTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRD 1733

Query: 134  DEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQK 193
             E +    Q+   +L E   L   L Q+L   + +  +  + + + E+ +     +  + 
Sbjct: 1734 KEKEVECQQEHIHELQE---LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEA 1790

Query: 194  AEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQD 253
             E+ ++ E SL+        +    D                       + E+   E Q 
Sbjct: 1791 REQGELKEQSLQSQLDEAQRALAQRDQ----------------------ELEALQQEQQQ 1828

Query: 254  AVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKC 313
            A               V     A   + E+A M + E + +L+    + K+Q R L+E+ 
Sbjct: 1829 A---------QGQEERVKEKADALQGALEQAHMTLKERHGELQ----DHKEQARRLEEEL 1875

Query: 314  FVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQ 373
             V              + +  E+++  +    R+ ++  LA Q + AE+ ++++V   + 
Sbjct: 1876 AV-----------EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRAL 1924

Query: 374  ERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKL 433
            +    Q +  L+E      +L    Q+    +E  +++ + LQE L +     Q   Q L
Sbjct: 1925 QDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHL 1984

Query: 434  SPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQ 493
              + +     +      +  L++      Q  E  ++ E  +++                
Sbjct: 1985 LEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQD---------------- 2028

Query: 494  PHKNINITFEED--KVNSALVV-DRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPL 550
                 ++ ++ED  ++  AL   D E  H + ++ +    +    +     +M+     L
Sbjct: 2029 ----QDLRYQEDVQQLQQALAQRDEELRHQQEREQL----LEKSLAQRVQENMIQEKQNL 2080

Query: 551  SSEKAEMNILEMNEKLRP---QLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKD 607
              E+ E  I  +++ +R     LA+K+Q+   L+E              Q +   E    
Sbjct: 2081 GQEREEEEIRGLHQSVRELQLTLAQKEQEILELRE-------------TQQRNNLEALPH 2127

Query: 608  LIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREK-------LREGRD 660
              K+    E+  K + L  +L++  EL + +  +   E    + REK       L + + 
Sbjct: 2128 SHKTSPMEEQSLKLDSLEPRLQR--ELERLQAALRQTEAREIEWREKAQDLALSLAQTKA 2185

Query: 661  ASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSP------ENDNDHDE 714
            +  SL +    L        S+ Q LQ++L E  R A +  +  SP      E  +  ++
Sbjct: 2186 SVSSLQEVAMFLQASVLERDSEQQRLQDEL-ELTRRALEKERLHSPGATSTAELGSRGEQ 2244

Query: 715  DVQVEVAEKVQKSSAPREMQK 735
             VQ+     V+   +P  M+K
Sbjct: 2245 GVQLGEVSGVEAEPSPDGMEK 2265



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 140/684 (20%), Positives = 263/684 (38%), Gaps = 107/684 (15%)

Query: 59   KYEECKDLIKFMLRNERQFKEE---KLAEQLKQAEELRQYKVLVHSQERELTQLREKLRE 115
            K EE    ++  LR+ ++ KEE   KL+E   Q E        +H + +   ++  +  +
Sbjct: 670  KAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQ 729

Query: 116  GRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQ 175
             ++A       L+  L   E D+   QDL EQL +G   A+ L++  S    + ++  ++
Sbjct: 730  EKEALVREKAALEVRLQAVERDR---QDLAEQL-QGLSSAKELLES-SLFEAQQQNSVIE 784

Query: 176  VEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDK 235
            V + +  ++     + ++  + +V    LE   +    S    + +   + +    +E K
Sbjct: 785  VTKGQLEVQIQTVTQAKEVIQGEVRCLKLE---LDTERSQAEQERDAAARQLAQAEQEGK 841

Query: 236  VNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKL 295
               T +  ++++H++    VN L        + +   +  A     E  E   +E+  +L
Sbjct: 842  ---TALEQQKAAHEK---EVNQLREKWEKERSWHQQELAKA----LESLEREKMELEMRL 891

Query: 296  RPQLAEKKQ-QFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLA 354
            + Q  E +  Q +  +E+   TQ    L   Q + + E    L++++L+ +++     LA
Sbjct: 892  KEQQTEMEAIQAQREEER---TQAESALCQMQLETEKERVS-LLETLLQTQKE-----LA 942

Query: 355  EQLKQAEELRQYKVLVHSQERELT------------QLREKLREGRDASRSLNQHLQALL 402
            +  +Q E LRQ   +   +E+E T            +L+E  R+ RD   +L +   +LL
Sbjct: 943  DASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLL 1002

Query: 403  TPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREV 462
                  + Q +DL+ QL                   +D    V+ E  EK+ E+     +
Sbjct: 1003 QDKMDLQKQVEDLKSQLVA----------------QDDSQRLVEQEVQEKLRETQEYNRI 1046

Query: 463  QKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVN----SALVVDRESS 518
            QK  E        E+ ++T S         +  + + +  E D +     SAL  D + +
Sbjct: 1047 QKELER-------EKASLTLS-------LMEKEQRLLVLQEADSIRQQELSALRQDMQEA 1092

Query: 519  HDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFR 578
              E ++    + +            +     L  E    +I E   +      E K    
Sbjct: 1093 QGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL 1152

Query: 579  NLKEKCFVTQLACFLANQQNKYK----------YEECKDLIKSVLRNERQFK-------- 620
             L+ +   +QL    A QQ   +          Y   +  + SV  +  +          
Sbjct: 1153 QLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPS 1212

Query: 621  ------EEKLAEQL-KQAEELRQYKV-LVHSQERELTQLREKLREGRDASRSLNQHLQAL 672
                  ++  A  L K+   L       V S   +L Q   K ++ RD  R   Q L+  
Sbjct: 1213 VWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEER 1272

Query: 673  LTPDEPDKSQG----QDLQEQLAE 692
            LT  E +KSQ     QDLQ QL++
Sbjct: 1273 LTDTEAEKSQVHTELQDLQRQLSQ 1296


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 172/759 (22%), Positives = 305/759 (40%), Gaps = 121/759 (15%)

Query: 18  LEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKYEECKDLIKFMLRNERQF 77
           LE+ E  R  L E   Q   ++++  + +LA  L N ++     E K+L +  LR++ + 
Sbjct: 235 LELAEN-RKLLTEKDAQIAMMQQR--IDRLA--LLNEKQAASPLEPKELEE--LRDKNES 287

Query: 78  KEEKLAEQLKQAEELRQYKVLVHSQERELTQ----LREKLREGRDASRSLNQHLQALLTP 133
              +L E LKQ ++L+  K  +  +  +L++    L  KLRE     + L   L  L   
Sbjct: 288 LTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEE 347

Query: 134 DEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQK 193
                 +  + Q QL +    A    + L  +N+  + +  Q+EE    L+ + P+E  +
Sbjct: 348 HSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGE 407

Query: 194 AEESKVPEDSLEECAITCSNSHGP-------CDSNQPHKNINIT-----FEEDKVN-STL 240
                +  ++L++ A T + ++          ++ +  +   +      FEE+K   S+L
Sbjct: 408 VLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSL 467

Query: 241 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 300
           + D +SS      A   L      S A    +      L+SE   +N     +    +LA
Sbjct: 468 ITDLQSSISNLSQAKEELE---QASQAHGARLTAQVASLTSELTTLNATIQQQD--QELA 522

Query: 301 EKKQQFRNLKEKCFVTQLAGFLANQQNKYK--YEECEDLIKSMLRNERQFKEEKLAEQLK 358
             KQQ    KEK    QLA  L  Q+   +    + E L  S+ + E+Q KE  +AE+ +
Sbjct: 523 GLKQQ---AKEK--QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE--VAEKQE 575

Query: 359 QAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQ 418
              +    ++   ++ERE   LRE     RDA+    + L+AL    E +K+   ++   
Sbjct: 576 ATRQDHAQQLATAAEERE-ASLRE-----RDAAL---KQLEAL----EKEKAAKLEI--- 619

Query: 419 LAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEEC 478
                     L Q+L   N+  +     V +A++          +KAE S+  E+ L+ C
Sbjct: 620 ----------LQQQLQVANEARDSAQTSVTQAQR----------EKAELSRKVEE-LQAC 658

Query: 479 AITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSA 538
             T         +      + +  E+ K      V +E   D+ Q+ +           A
Sbjct: 659 VETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEK--DQLQEQL----------QA 706

Query: 539 TNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQN 598
              S+ V+ G L  EK      +  E+ +  ++E K + R+L E+           +++ 
Sbjct: 707 LKESLKVTKGSLEEEK--RRAADALEEQQRCISELKAETRSLVEQ-----------HKRE 753

Query: 599 KYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREG 658
           + + EE +   K +    +Q  E   AE      EL +     H+ E E  QL +++   
Sbjct: 754 RKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAW 813

Query: 659 RDASRSLNQHLQALLTPDEPDKSQGQDLQEQ---LAEGCRLAQQLFQKLSPE--NDNDHD 713
           R+      Q           +   G   QEQ   L E C  A+Q  Q+   +      H 
Sbjct: 814 RERYEDSQQE----------EAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863

Query: 714 E----DVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEE 748
           E      Q E+AE    ++  R +Q+ +EKEV    L +
Sbjct: 864 ELQISRQQNELAE--LHANLARALQQVQEKEVRAQKLAD 900



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 118/502 (23%), Positives = 208/502 (41%), Gaps = 54/502 (10%)

Query: 279 LSSEKAEMNILEMN-EKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDL 337
           L+ E++  + LE+   + R  L EK  Q   ++++  + +LA  L N++      E ++L
Sbjct: 223 LADERSNRDELELELAENRKLLTEKDAQIAMMQQR--IDRLA--LLNEKQAASPLEPKEL 278

Query: 338 IKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ----LREKLREGRDASRS 393
            +  LR++ +    +L E LKQ ++L+  K  +  +  +L++    L  KLRE     + 
Sbjct: 279 EE--LRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336

Query: 394 LNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKV 453
           L   L  L         +  + Q QL +    A    + L  +N+  + +  Q+EE    
Sbjct: 337 LQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ 396

Query: 454 LESSAPREVQKAEESKVPEDSLEECAITCSNSHGP-------CDSNQPHKNINIT----- 501
           L+ + P+E  +     +  ++L++ A T + ++          ++ +  +   +      
Sbjct: 397 LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGH 456

Query: 502 FEEDKVN-SALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNIL 560
           FEE+K   S+L+ D +SS      A   L      S A    +      L+SE   +N  
Sbjct: 457 FEEEKQQLSSLITDLQSSISNLSQAKEELE---QASQAHGARLTAQVASLTSELTTLNAT 513

Query: 561 EMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYK--YEECKDLIKSVLRNERQ 618
              +    +LA  KQQ    KEK    QLA  L  Q+   +    + + L  S+ + E+Q
Sbjct: 514 IQQQD--QELAGLKQQ---AKEK--QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ 566

Query: 619 FKE---------EKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHL 669
            KE         +  A+QL  A E R+    +  ++  L QL    +E       L Q L
Sbjct: 567 LKEVAEKQEATRQDHAQQLATAAEERE--ASLRERDAALKQLEALEKEKAAKLEILQQQL 624

Query: 670 QALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSA 729
           Q      +  ++     Q + AE  R  ++L   +       H+   QV   E   +S  
Sbjct: 625 QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS-- 682

Query: 730 PREMQKAEEKE---VPEDSLEE 748
             E QKA EKE     +D L+E
Sbjct: 683 --EQQKATEKERVAQEKDQLQE 702



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 170/757 (22%), Positives = 290/757 (38%), Gaps = 135/757 (17%)

Query: 79   EEKLAEQLKQAE----ELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPD 134
            +E LA  L + E    EL + + L  +Q +EL +LR+ +++           L+  L   
Sbjct: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQ-----------LKEQLAKK 1097

Query: 135  EPDKSQGQDLQEQLA-----EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR 189
            E + + G   Q + A      G +L + L  ++S    + + +  Q +  E+ LE+    
Sbjct: 1098 EKEHASGSGAQSEAAGRTEPTGPKL-EALRAEVSKLEQQCQKQQEQADSLERSLEAERAS 1156

Query: 190  EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHD 249
              ++    +  +  LEE A    +S     S Q          E     T V D   + D
Sbjct: 1157 RAERDSALETLQGQLEEKAQELGHSQSALASAQ---------RELAAFRTKVQDHSKAED 1207

Query: 250  ECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNL 309
            E +  V      G   +    S++      SS + E++IL        Q+ EK+ + + L
Sbjct: 1208 EWKAQV----ARGRQEAERKNSLI------SSLEEEVSILNR------QVLEKEGESKEL 1251

Query: 310  KEKCFVTQLAGFLANQQNKYKYEECEDLIK--------------SMLRNERQFKEEKLAE 355
            K           +A  +   K EE   L++              S LR E Q   E+  +
Sbjct: 1252 KRLV--------MAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEK 1303

Query: 356  QLKQAEELRQYKVLVHSQERELTQ----LREKLREGRDASRSLN-QHL--QALLTPDEPD 408
            Q   +E LRQ       +  EL Q     +EK  +   A  +L  +H   QAL++   P 
Sbjct: 1304 QRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPA 1363

Query: 409  KSQGQDLQ-EQLAEGCRLAQHLVQ-KLSPENDEDEDEDVQVEEAEKV-LESSAPREVQKA 465
            K   Q LQ EQ A   R  + L Q K +      E    Q E  E + L      + + A
Sbjct: 1364 KHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA 1423

Query: 466  EESKVPEDSLEECAITCSNSHGP-CDSNQ---PHKNINITFEEDKVNSALVVDRESSHDE 521
            ++ +  + S  E       +HG   + N+      N+   F E +++ A    RE    E
Sbjct: 1424 QQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQA----REKYVQE 1479

Query: 522  CQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLK 581
               AV          + T ++ V      ++ + E+   +  E  + ++ E++Q+F+  +
Sbjct: 1480 LA-AVR-------ADAETRLAEVQREAQSTARELEVMTAKY-EGAKVKVLEERQRFQEER 1530

Query: 582  EKCF--VTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKV 639
            +K    V QL  F   +Q K   E  K L  S   ++ Q  ++KL     Q  E +Q   
Sbjct: 1531 QKLTAQVEQLEVF-QREQTKQVEELSKKLADSDQASKVQ--QQKLKAVQAQGGESQQEAQ 1587

Query: 640  LVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQL--------- 690
             + +Q   L +L+ +L +   A+      ++   T  +  K Q Q+LQEQL         
Sbjct: 1588 RLQAQ---LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKE 1644

Query: 691  -----AEGCRLAQQLFQ---KLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVP 742
                 AE  RL  +L Q   K             QV   E  Q + A ++++   + +V 
Sbjct: 1645 NKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLE-AQVAHADQQLRDLGKFQVA 1703

Query: 743  EDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVD 779
             D+L+              S +P  K ++    D +D
Sbjct: 1704 TDALK--------------SREPQAKPQLDLSIDSLD 1726



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 150/725 (20%), Positives = 283/725 (39%), Gaps = 132/725 (18%)

Query: 54   RQKKYKYEECKDLIKFMLRNERQ--FKEEKLAEQLKQAEELRQ-----YKVLVHSQEREL 106
            RQ++++ +     ++  LR+E+Q   ++E++A++  Q +E  Q      KV   S E E 
Sbjct: 663  RQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEK 722

Query: 107  TQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEN 166
             +  + L E +     L    ++L+   E  K + ++L+E+ A G +  +  +Q+L  E 
Sbjct: 723  RRAADALEEQQRCISELKAETRSLV---EQHKRERKELEEERA-GRKGLEARLQQLG-EA 777

Query: 167  DEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKN 226
             + E E ++ E AE +         Q   ES+  E  ++E A          DS Q    
Sbjct: 778  HQAETEVLRRELAEAM-------AAQHTAESEC-EQLVKEVAAWRERYE---DSQQEEAQ 826

Query: 227  INITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEM 286
                F+E  +  TL  + E +  E Q+A               V+ + S   L   + + 
Sbjct: 827  YGAMFQEQLM--TLKEECEKARQELQEA------------KEKVAGIESHSELQISRQQN 872

Query: 287  NILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECE-DLIKSMLRNE 345
             + E    L   LA   QQ +  +++    +LA  L+  Q K      E   +++++R  
Sbjct: 873  ELAE----LHANLARALQQVQ--EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKA 926

Query: 346  RQFKEEKLAEQLKQAEEL--RQYKVLVHSQERELTQLREKL----REGRDASRSLNQHLQ 399
             + +E    E +K+      RQ + L   Q R+    +  L    RE       L +   
Sbjct: 927  GEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA 986

Query: 400  ALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAP 459
            AL+      +SQGQ  +E+  +     +  V +L+ E            +A+  LE +A 
Sbjct: 987  ALM------ESQGQQQEERGQQ-----EREVARLTQERGR--------AQADLALEKAAR 1027

Query: 460  REVQKAEESKVPEDSLEECAITCSNSHGPCDSN-----------------QPHKNINITF 502
             E++   ++ + E  +E   +  + +H   +                   +  + +  T 
Sbjct: 1028 AELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087

Query: 503  EEDKVNSALVVDRESSHDECQ-DAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILE 561
            ++ K   A      +S    Q +A       GP   A    +         ++ + + LE
Sbjct: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147

Query: 562  MN---------------EKLRPQLAEKKQQFRNLKEKCFVTQ--LACFLANQQNKYKYE- 603
             +               E L+ QL EK Q+  + +      Q  LA F    Q+  K E 
Sbjct: 1148 RSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAED 1207

Query: 604  -------------ECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ 650
                         E K+ + S L  E      ++ E+  +++EL++   LV ++  +  +
Sbjct: 1208 EWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR---LVMAESEKSQK 1264

Query: 651  LREKLR---------EGRDASRS--LNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQ 699
            L E+LR           R A RS  L + +Q+L    E  +   ++L+++L      A++
Sbjct: 1265 LEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEE 1324

Query: 700  LFQKL 704
            L Q+L
Sbjct: 1325 LGQEL 1329



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 102/468 (21%), Positives = 187/468 (39%), Gaps = 64/468 (13%)

Query: 3    VSAGPWSSEKAETNILEINEK---LRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYK 59
            V+ G   +E+  + I  + E+   L  Q+ E + + + LK           +A  +K  K
Sbjct: 1213 VARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLV--------MAESEKSQK 1264

Query: 60   YEECKDLIKF--------------MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERE 105
             EE   L++                LR E Q   E+  +Q   +E LRQ       +  E
Sbjct: 1265 LEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEE 1324

Query: 106  LTQ----LREKLREGRDASRSLN-QHL--QALLTPDEPDKSQGQDLQ-EQLAEGCRLAQH 157
            L Q     +EK  +   A  +L  +H   QAL++   P K   Q LQ EQ A   R  + 
Sbjct: 1325 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREE 1384

Query: 158  LVQ-KLSPENDEDEDEDVQVEEAEKV-LESSAPREVQKAEESKVPEDSLEECAITCSNSH 215
            L Q K +      E    Q E  E + L      + + A++ +  + S  E       +H
Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAH 1444

Query: 216  GPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVS 275
            G        +N  +    +     L V+ + + ++    +  +       + T ++ V  
Sbjct: 1445 GLL----AEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRA----DAETRLAEVQR 1496

Query: 276  AGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCF--VTQLAGFLANQQNKYKYEE 333
                ++ + E+   +  E  + ++ E++Q+F+  ++K    V QL  F   Q      ++
Sbjct: 1497 EAQSTARELEVMTAKY-EGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQT-----KQ 1550

Query: 334  CEDLIKSMLRNERQFK--EEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 391
             E+L K +  +++  K  ++KL     Q  E +Q    + +Q   L +L+ +L +   A+
Sbjct: 1551 VEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQ---LNELQAQLSQKEQAA 1607

Query: 392  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDE 439
                  ++   T  +  K Q Q+LQEQL          +++L  EN E
Sbjct: 1608 EHYKLQMEKAKTHYDAKKQQNQELQEQLRS--------LEQLQKENKE 1647


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 199/994 (20%), Positives = 386/994 (38%), Gaps = 88/994 (8%)

Query: 103  ERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKL 162
            E E  +L EK +E ++  +SL +    L T  E  + +   L+E + E     Q    K 
Sbjct: 1327 EMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQ 1386

Query: 163  SP-----ENDEDEDEDVQVEEAEKVLESSAPR-EVQKAEESKVPEDSLEECAITCSNSHG 216
                   E D +  + V   E  K  +S+  R E++    SK  ++S +E          
Sbjct: 1387 EQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKD- 1445

Query: 217  PCDSNQPHKNINITFEEDKVNSTLVVDRE-SSHDECQDAVNILPVPGPTSSATNVSMVVS 275
              D  +  + +    ++ K N   +V +   + +E + A   L     T +   V++   
Sbjct: 1446 --DLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEK 1503

Query: 276  AGPLSSEKAEMNILEMNEKLR---PQLAEKKQQFRNLKEKCFVTQLAGFLAN--QQNKYK 330
               +S+ + ++  +  N+KL+    ++ EK++QF N+K+   V +    L    +  K K
Sbjct: 1504 ETEISTIQKQLEAI--NDKLQNKIQEIYEKEEQF-NIKQISEVQEKVNELKQFKEHRKAK 1560

Query: 331  YEECEDLIKSMLR--NERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ-LREKLREG 387
                + +   ML   N  Q  +E++   +K+ EE+++ +  +  +  +L +  +E + + 
Sbjct: 1561 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM 1620

Query: 388  RDASRSLNQHLQALLTPDEPDK------------SQGQDLQEQLAEGCRLAQHLVQKLSP 435
            +++     Q L+     +  +K            +Q  +L+    E  RL Q L + L  
Sbjct: 1621 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE 1680

Query: 436  END--EDEDEDVQVEEAEKV--------LESSAPREVQKAEESKVPEDSLEECAITCSNS 485
                 ++ D+   VEE  KV        L  +  R+++K EE K+    L+E   T    
Sbjct: 1681 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL 1740

Query: 486  HGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVV 545
             G   S + ++  N+  + +  N AL        +E + A   L     T       +  
Sbjct: 1741 RGIV-SEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSE 1799

Query: 546  SAGPLSSEKAEMNILEMNEKLRPQLAEKK---QQFRNLKEKCFVTQLACFLANQQNKYKY 602
                LS+ + ++     N KL+ ++ E K    Q   LK+    TQ       Q  K   
Sbjct: 1800 KTDKLSNMQKDLE--NSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIK 1857

Query: 603  EECKDLIKSVLRNER--QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 660
            ++   L K  + N    Q   E L E     +E    + +  + + E  QL+E L+E + 
Sbjct: 1858 DQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKA 1917

Query: 661  ASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEV 720
                + Q L+      +  K     L+E+++E       + + L    D +  + +Q   
Sbjct: 1918 RDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKD-ELQKKIQELQ 1976

Query: 721  AEKVQKSSAPREMQKAEEKEVPEDSLEEC--AITCSNSHGPYDSNQPHRKTKITFEEDKV 778
             +++Q      ++  + +K    + L++   A   S      D+ Q  +K   + EE ++
Sbjct: 1977 KKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRI 2036

Query: 779  ------DSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESW 832
                  +   I  S  +E +  +  + E  + D +  +   V P     S+ ++   ES 
Sbjct: 2037 VAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQ---VKPEKRLLSDGQQHLTESL 2093

Query: 833  DEGYSTLSIPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSR 892
             E  S +    E+L  Y      +  L    + +  +I      + +KE        LS 
Sbjct: 2094 REKCSRIK---ELLKRYSEMDDHYECLNRLSLDLEKEI------EFQKELSMRVKANLSL 2144

Query: 893  ELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVG-WALD-MDEIEK 950
              L  K  E L  +  RC       ++       Y +     + + +  + +D +DE+EK
Sbjct: 2145 PYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEK 2204

Query: 951  YQEVE---EDQDPSCPRLSRELLDEKE--------PEVLQDSLDRCYSTPSGYLELPDLG 999
             +E+    +     C   SREL D K          E+L+D  +  +  PS   E   + 
Sbjct: 2205 QKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEF--PSIKTEFQQVL 2262

Query: 1000 QPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQ 1033
               +     LEE +L    D++++K   ++E D+
Sbjct: 2263 SNRKEMTQFLEE-WLNTRFDIEKLKNGIQKENDR 2295



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 164/875 (18%), Positives = 346/875 (39%), Gaps = 119/875 (13%)

Query: 18   LEINEKLRPQLAENK---QQFRNLKEKCFVTQLAGFLANRQKKYKYEECKDLIKFMLRNE 74
            ++  +K +  L EN+   Q+  NL ++      +      +  YK +E ++  + +   E
Sbjct: 827  MDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREV--QE 884

Query: 75   RQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPD 134
            R  + E+L EQL+  +   Q      + ERE T + EKL++  +  ++L Q         
Sbjct: 885  RLNEMEQLKEQLENRDSTLQ------TVEREKTLITEKLQQTLEEVKTLTQ--------- 929

Query: 135  EPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKV---LES-SAPRE 190
              +K   + LQE L          +++   ++D  +  ++ ++  E++   LES    +E
Sbjct: 930  --EKDDLKQLQESLQ---------IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE 978

Query: 191  VQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDE 250
                 +SK+ E+                 S   H   N    +D+    +V   +    E
Sbjct: 979  TINTLKSKISEEV----------------SRNLHMEENTGETKDEFQQKMVGIDKKQDLE 1022

Query: 251  CQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLK 310
             ++   +      T+   +  ++     + S   E N  E+ + L   +AEK+Q   +LK
Sbjct: 1023 AKNTQTL------TADVKDNEIIEQQRKIFSLIQEKN--ELQQMLESVIAEKEQLKTDLK 1074

Query: 311  EKCFVT-------QLAGFLANQQNKYKYEECEDLIK-----SMLRNERQFKEEKLAEQLK 358
            E   +T       +L G    +Q +   +E    IK     S   +     EEKL E+ +
Sbjct: 1075 ENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQ 1134

Query: 359  QAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQ 418
            Q +E +Q   L++ QE E++++++K+ E  +    L      L    E  +++  +L ++
Sbjct: 1135 QLQEKQQQ--LLNVQE-EMSEMQKKINEIENLKNELKNKELTL----EHMETERLELAQK 1187

Query: 419  LAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEEC 478
            L E     + + ++     +  +  + + +     +       +Q  EE K+    L+E 
Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEH 1247

Query: 479  AITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSA 538
              T         S +  + IN T + +K ++ L  +    H+E +   N+  V     + 
Sbjct: 1248 QETIDELRRSV-SEKTAQIIN-TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETM 1305

Query: 539  TNVSMVVSAGPLSSE----KAEMNILEMNEKLR------PQLAEKKQQFRNLKEKCFVTQ 588
              + ++             + EM  L +NEK +        L +++   + +KE   V  
Sbjct: 1306 NELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKH 1365

Query: 589  LACFLANQQNKYKYEECKDLIKSVLRNERQFK-EEKLAEQLKQAEELRQYK---VLVHSQ 644
                  +Q  ++  E    + +S  + E+    +EK  E  K   E+ Q+K     +   
Sbjct: 1366 ------DQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRI 1419

Query: 645  ERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAE------------ 692
            E E+  L ++L+E  D  +S+ +    L    E  +S+   L+E + E            
Sbjct: 1420 EIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEEL 1479

Query: 693  ---GCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEEC 749
                C L +Q  + ++    N  +++ ++   +K  ++   +   K +E    E+     
Sbjct: 1480 KVAHCCLKEQ-EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIK 1538

Query: 750  AIT-CSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEE 808
             I+            + HRK K +  +      L  ++   E ++ + I+ + + + +  
Sbjct: 1539 QISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRV 1598

Query: 809  EEKGPVSPRNLQESEEEEVP--QESWDEGYSTLSI 841
            +E   +    L+E+ +E V   +ES ++ Y  L +
Sbjct: 1599 QEALQIERDQLKENTKEIVAKMKESQEKEYQFLKM 1633



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 140/732 (19%), Positives = 285/732 (38%), Gaps = 136/732 (18%)

Query: 18   LEINEKLRPQ---LAENKQQFRNLKEKCFVTQLAGFLANRQKKYKYEECKDLIKFMLRNE 74
            LE  E+L+     L E ++    L+      +       +Q +   ++ ++ I+ +   E
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKE 1532

Query: 75   RQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPD 134
             QF  ++++E  ++  EL+Q+K    +++  L  +  K+ E  +  +   + +Q ++   
Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK 1592

Query: 135  EPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQV----EEAEKVLESSAPRE 190
            E  K   + LQ +  +     + +V K+  E+ E E + +++    E  EK+ E    +E
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMK-ESQEKEYQFLKMTAVNETQEKMCEIEHLKE 1651

Query: 191  VQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNI----NITFEED---KVNSTLVVD 243
              + ++  +     E   +T             H+N+    ++T E D    V  TL V+
Sbjct: 1652 QFETQKLNLENIETENIRLT----------QILHENLEEMRSVTKERDDLRSVEETLKVE 1701

Query: 244  RESSHDECQDAV----------------------NILPVPGPTSSATN-VSMVVSAGPLS 280
            R+   +  ++ +                       I  + G  S  TN +S +      S
Sbjct: 1702 RDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS 1761

Query: 281  SEKAEMNILEMNEKLR-PQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYE--ECEDL 337
            ++  +   L++ E+LR   +  K+QQ    K +  V++    L+N Q   +    + ++ 
Sbjct: 1762 NDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEK 1821

Query: 338  IKSMLRNERQF--KEEKLAEQLKQAEELRQYKVLVHSQERELTQLR-------EKLREGR 388
            I+ +  NE Q    ++ + E  K+  E+ Q K  +  Q   L++L        +KL E  
Sbjct: 1822 IQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENL 1881

Query: 389  DASRSLNQHLQALLTPDEPDKSQGQDLQEQL----AEGCRLAQHL--VQKLSPENDEDED 442
            +  +S+ +    L   +E  K +   L+E L    A    + Q L   + LS E+ E  D
Sbjct: 1882 EEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVD 1941

Query: 443  --------EDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQP 494
                    + +Q+ + +K L+ S     +K +E +  E  L              D N  
Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKE---------DVNMS 1992

Query: 495  HKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEK 554
            HK IN             +++     E Q+                         LS + 
Sbjct: 1993 HKKIN------------EMEQLKKQFEAQN-------------------------LSMQS 2015

Query: 555  AEMNILEMNEKLRPQL------AEKKQQFRNLKEKC------FVTQLACFLANQQNKYKY 602
              M+  ++ +KL   L      A+++ + R +KE        F+  L   +A  +  ++ 
Sbjct: 2016 VRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQV 2075

Query: 603  EECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 662
            +  K L    L + +Q   E L E+  + +EL +    +      L +L   L +  +  
Sbjct: 2076 KPEKRL----LSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQ 2131

Query: 663  RSLNQHLQALLT 674
            + L+  ++A L+
Sbjct: 2132 KELSMRVKANLS 2143



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 145/767 (18%), Positives = 302/767 (39%), Gaps = 153/767 (19%)

Query: 59   KYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQER-------------- 104
            K ++ K L +++   + +  +  L+  L+  E+ +Q K  +   E               
Sbjct: 587  KEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRS 646

Query: 105  ELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP 164
            E  +L+EK++E     + +   +Q   +  E  K    DL+++L         L   +  
Sbjct: 647  ENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDG 706

Query: 165  ENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPH 224
            +  +D   ++++E     L+    +EV++ E  +      EE  +       P +  +  
Sbjct: 707  KVPKDLLCNLELEGKITDLQKELNKEVEENEALR------EEVILLSELKSLPSEVERLR 760

Query: 225  KNIN--------ITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSS--ATNVSMVV 274
            K I         IT E+DK+ S  VV +ES          +L   G T    AT  S   
Sbjct: 761  KEIQDKSEELHIITSEKDKLFSE-VVHKESR------VQGLLEEIGKTKDDLATTQSNYK 813

Query: 275  SAGP---------LSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQ 325
            S            +  E+    +LE NE++  ++    ++ +      F + L       
Sbjct: 814  STDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQK-----FDSSLGAL--KT 866

Query: 326  QNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLR 385
            +  YK +E ++  + +   ER  + E+L EQL+  +   Q      + ERE T + EKL+
Sbjct: 867  ELSYKTQELQEKTREV--QERLNEMEQLKEQLENRDSTLQ------TVEREKTLITEKLQ 918

Query: 386  EGRDASRSLNQHLQAL-------------LTPDEPDK-SQGQDLQEQL---AEGCRLAQH 428
            +  +  ++L Q    L             L  D  D  +   D QEQL    E  +  Q 
Sbjct: 919  QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE 978

Query: 429  LVQKLSPENDEDEDEDVQVEE---------AEKVLESSAPREVQKAEESKVPEDSLEECA 479
             +  L  +  E+   ++ +EE          +K++     ++++      +  D  +   
Sbjct: 979  TINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEI 1038

Query: 480  ITCSNSHGPCDSNQPHKNINITFEEDKVNSAL---VVDRESSHDECQDAVNI-------L 529
            I            Q  K  ++  E++++   L   + ++E    + ++ + +       L
Sbjct: 1039 I-----------EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEEL 1087

Query: 530  PVPGPTSSATNVSMVVSAGPLSSEKAEMN-----ILEMNEKLR---PQLAEKKQQFRNLK 581
             + G         +         ++ E++     + E+ EKL+    QL EK+QQ  N++
Sbjct: 1088 RLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQ 1147

Query: 582  EKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLV 641
            E+             + + K  E ++L K+ L+N+    E    E+L+ A++L +     
Sbjct: 1148 EEM-----------SEMQKKINEIENL-KNELKNKELTLEHMETERLELAQKLNEN---- 1191

Query: 642  HSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLF 701
            + + + +T+ R+ L+E + +  +   HL+  +   E   + G   +E+L           
Sbjct: 1192 YEEVKSITKERKVLKELQKSFETERDHLRGYIREIE---ATGLQTKEEL----------- 1237

Query: 702  QKLSPENDNDHDE---DVQVEVAEKVQKSSAPREMQKAEEK---EVP 742
             K++  +  +H E   +++  V+EK  +    ++++K+  K   E+P
Sbjct: 1238 -KIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIP 1283


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 200/954 (20%), Positives = 382/954 (40%), Gaps = 154/954 (16%)

Query: 78   KEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPD 137
            ++E+L ++L++A   R+  +L  +QE+E   LRE+L++ +D    L +        +E  
Sbjct: 1172 EKEQLQKKLQEALTSRK-AILKKAQEKE-RHLREELKQQKDDYNRLQEQFDEQSKENENI 1229

Query: 138  KSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEES 197
              Q + LQ Q+ E        +    P  D+ E         E + +++     Q   ES
Sbjct: 1230 GDQLRQLQIQVRES-------IDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLES 1282

Query: 198  KV----PEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHD--EC 251
             +    P  S +  A+    S     +            E KV+ST     + S +  + 
Sbjct: 1283 NLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQL 1342

Query: 252  QDAVNILPVPGPTSSATNVSMVVSAGPLSS--EKAEMNI--LEMNEKLRPQLAEKKQQFR 307
            Q+ +N   +   +    +    V A  L    E +++ I  LE   +L+P+L E ++   
Sbjct: 1343 QEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS 1402

Query: 308  NLKEKCFVTQLAGFLANQQ---NKYKYE--ECEDLIKSMLRNERQFKEEKLAEQLKQAEE 362
              +E   V+ L+G L+ ++    K + E  E EDLIK+ L  + + + ++  E++KQ   
Sbjct: 1403 KKEED--VSYLSGQLSEKEAALTKIQTEIIEQEDLIKA-LHTQLEMQAKEHDERIKQ--- 1456

Query: 363  LRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEG 422
                   +  +  E+ Q  E++ E   A + + + LQA L   +    + + LQE+L+  
Sbjct: 1457 -------LQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELS-- 1507

Query: 423  CRLAQHLVQKLSPENDEDEDEDVQVEEAEK--------VLESSAPREVQKAEESKVPEDS 474
              LA+  +++L+ ++  D +  V  +  EK        +L+    + + + + S +   S
Sbjct: 1508 --LARGTIERLT-KSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQS 1564

Query: 475  LEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDR---ESSHDECQDAVNILPV 531
            L     +C +     +     K   +  E + + S+ + +    +  H E Q    IL  
Sbjct: 1565 LSS---SCESLKLALEGLTEDKE-KLVKEIESLKSSKIAESTEWQEKHKELQKEYEIL-- 1618

Query: 532  PGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAC 591
                 S  NVS          E       E+  KLR   A KK+  + L+E         
Sbjct: 1619 ---LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE--------- 1666

Query: 592  FLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELR--------QYKVLVHS 643
              A Q+ +   E+ +   KS        K++K+ E  ++ + LR          K  + +
Sbjct: 1667 --AEQEMEEMKEKMRKFAKS--------KQQKILELEEENDRLRAEVHPAGDTAKECMET 1716

Query: 644  QERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQK 703
                   ++E+L   +    +L++  Q+L++  +    + QDL+ Q+ EG  +++Q   +
Sbjct: 1717 LLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI-EG-NVSKQANLE 1774

Query: 704  LSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLE-ECAITCSNSHGPYDS 762
             + ++DN      Q  V E+    S P E ++       +DSL      TCS S     S
Sbjct: 1775 ATEKHDN------QTNVTEE-GTQSIPGETEE-------QDSLSMSTRPTCSESVPSAKS 1820

Query: 763  NQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQES 822
              P   +K     D++++ L            +  + E  +  EEE++K     + L+  
Sbjct: 1821 ANP-AVSKDFSSHDEINNYL----------QQIDQLKERIAGLEEEKQKNKEFSQTLENE 1869

Query: 823  EEEEVPQESWDEGYSTL------------SIPPEMLASYQSYSGTFH----SLEEQQVCM 866
            +   + Q S  +G   +                E L+       T       LEE+ +  
Sbjct: 1870 KNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQ 1929

Query: 867  AVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQP 926
              ++ G     +    Q+ T  ++  ELL+ +       +L +C S      EL +  Q 
Sbjct: 1930 LAELNG----SIGNYCQDVTDAQIKNELLESE-----MKNLKKCVS------ELEEEKQQ 1974

Query: 927  YRSAFYILEQQRVGWALDMDEIEKYQEVE-EDQDPSCPRLSRELLDEKEPEVLQ 979
                  + E+ +V   +  + +EK Q  + E  + S  +  +ELL EK+ EV Q
Sbjct: 1975 -----LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQ 2023



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 151/695 (21%), Positives = 280/695 (40%), Gaps = 105/695 (15%)

Query: 71   LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 130
            L+ E Q  +E +  Q+KQ +E  + + L  ++E+ L + ++ ++E  DA R    HL+  
Sbjct: 2101 LKKELQSNKESVKSQMKQKDEDLERR-LEQAEEKHLKE-KKNMQEKLDALRREKVHLEET 2158

Query: 131  L-----TPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLES 185
            +     T ++ DK + Q LQE L           + +S   D   D D  ++EA+K    
Sbjct: 2159 IGEIQVTLNKKDK-EVQQLQENLDSTVTQLAAFTKSMSSLQD---DRDRVIDEAKKWERK 2214

Query: 186  SAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVN-STLVVDR 244
             +     K EE ++ ED+   C++               + ++I  EE K+N S L  D+
Sbjct: 2215 FSDAIQSKEEEIRLKEDN---CSVL----------KDQLRQMSIHMEELKINISRLEHDK 2261

Query: 245  ESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNE--KLRPQLAEK 302
            +    + Q  V +      T    N  ++        E   +     NE  KL  +L   
Sbjct: 2262 QIWESKAQTEVQLQQKVCDTLQGENKELLSQL----EETRHLYHSSQNELAKLESELKSL 2317

Query: 303  KQQFRNLK---EKCFVTQ--LAGFLANQQ-----NKYKYEECE-DL-----IKSMLRNER 346
            K Q  +L    EKC   +  L G +  Q+     +K+ YE+ E DL     + S L  E 
Sbjct: 2318 KDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEI 2377

Query: 347  QFKEEKLAEQLKQAEELRQYKV--LVHSQERELTQLREKLREGRDASRSLNQ-HLQALLT 403
              KE+K+   L   EE  Q  +  L    ++E+ +L   L +  + +  L + + +A+  
Sbjct: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDK 2437

Query: 404  PDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDE--DEDVQVEEAEK--VLESSAP 459
             ++  ++     +E + +  +L   +    S +ND D    +  Q+EE     +LE    
Sbjct: 2438 TNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL 2497

Query: 460  REVQKAEESKVPED--SLEECAITCSNSHGPCDSN--QPHKNIN--ITFEEDKVNSALVV 513
             +   AE +K+ E+   L       ++ +   D+   Q  +++N  IT ++ +    L V
Sbjct: 2498 IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV 2557

Query: 514  DRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEK 573
              + +  E ++    L      S   N  +  S   L  EK +++  +  E L+  +++ 
Sbjct: 2558 QLQQNK-ELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS--KEIESLKVSISQL 2614

Query: 574  KQQFRNLKEKCF--------------VTQLACFLANQQNKY----------------KYE 603
             +Q   L+E+                V +L+   ++ Q +                 K  
Sbjct: 2615 TRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVG 2674

Query: 604  ECKDLIKS----------VLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLRE 653
            E +D +K           ++RNE +  EE++AE  +   E+ Q  ++V  + + LT   +
Sbjct: 2675 EIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQ 2734

Query: 654  KLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE 688
                GR  S   N    A    DE  +     L+E
Sbjct: 2735 SF--GRSMSSLQNSRDHANEELDELKRKYDASLKE 2767



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 164/882 (18%), Positives = 338/882 (38%), Gaps = 143/882 (16%)

Query: 81   KLAEQLKQAE-ELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKS 139
            ++  QLK+ E E  + ++ V S   ELT+  E++ + ++        +++L T     + 
Sbjct: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEV 1365

Query: 140  QGQDLQEQLAEGCRLA----QHLVQKLSPENDE------DEDEDV-----QVEEAEKVLE 184
              + LQ++L E  +L     +HL ++L P+ DE       ++EDV     Q+ E E  L 
Sbjct: 1366 HAESLQQKL-ESSQLQIAGLEHL-RELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALT 1423

Query: 185  SSAPREVQKAEESKVPEDSLEECAITCSNSHGP---------CDSNQPHKNINITFEEDK 235
                  +++ +  K     LE  A      H           C+  Q  + I    EE +
Sbjct: 1424 KIQTEIIEQEDLIKALHTQLEMQA----KEHDERIKQLQVELCEMKQKPEEIG---EESR 1476

Query: 236  VNSTL-------VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNI 288
                +       ++ R+ +  E +     L +   T      S+      +S++  E + 
Sbjct: 1477 AKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536

Query: 289  L--------EMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKS 340
            +        E  +KL  ++     + ++L   C   +LA     +  +   +E E L  S
Sbjct: 1537 VLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSS 1596

Query: 341  MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQA 400
             +    +++E       K  E  ++Y++L+ S E  ++   E+++   +A R   Q L  
Sbjct: 1597 KIAESTEWQE-------KHKELQKEYEILLQSYEN-VSNEAERIQHVVEAVRQEKQELYG 1648

Query: 401  LLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR 460
             L   E +K   ++ ++QL E  +  + + +K+       + + +++EE    L +    
Sbjct: 1649 KLRSTEANK---KETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRA---- 1701

Query: 461  EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEE-DKVNSALVVDRESSH 519
            EV  A       D+ +EC  T  +S+      +  + + + +E   K   +L+ +++S  
Sbjct: 1702 EVHPAG------DTAKECMETLLSSNA--SMKEELERVKMEYETLSKKFQSLMSEKDSLS 1753

Query: 520  DECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRN 579
            +E QD  + +          NVS   +         + N+ E   +  P   E++     
Sbjct: 1754 EEVQDLKHQIE--------GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSL-- 1803

Query: 580  LKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKV 639
                              +      C + + S      +     +++     +E+  Y  
Sbjct: 1804 ------------------SMSTRPTCSESVPSA-----KSANPAVSKDFSSHDEINNYLQ 1840

Query: 640  LVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQ 699
             +   +  +  L E+ ++ ++ S++L      LL+       + + LQE++ +   L QQ
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900

Query: 700  LFQKLS---------PENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECA 750
            + ++LS          E  +D +E +  ++AE     S     Q   + ++  + LE   
Sbjct: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAE--LNGSIGNYCQDVTDAQIKNELLESEM 1958

Query: 751  ITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEE 810
                       S     K ++  E+ KV+S +     ++E        P N+S  +E +E
Sbjct: 1959 KNLKKC----VSELEEEKQQLVKEKTKVESEI--RKEYLEKIQGAQKEPGNKSHAKELQE 2012

Query: 811  KGPVSPRNLQESEEEEVPQESWD-----EGYSTLSIPPEMLASYQSYSGTFHSLEEQQVC 865
                    L + +++EV Q   D     E  S L    + L   Q+ S     + ++ + 
Sbjct: 2013 --------LLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLA 2064

Query: 866  MAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSL 907
             AV+   HR    KK   E    ++  +    +   VL D+L
Sbjct: 2065 QAVE---HR----KKAQAELASFKVLLDDTQSEAARVLADNL 2099



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 157/779 (20%), Positives = 304/779 (39%), Gaps = 124/779 (15%)

Query: 23   KLRPQLAENKQQFRNLK---EKCFVTQ--LAGFLANRQ-----KKYKYEECK-DL----- 66
            KL  +L   K Q  +L    EKC   +  L G +  ++      K+ YE+ + DL     
Sbjct: 2309 KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRE 2368

Query: 67   IKFMLRNERQFKEEKLAEQLKQAEELRQYKV--LVHSQERELTQLREKLREGRDASRSLN 124
            +   L  E   KE+K+   L   EE  Q  +  L    ++E+ +L   L +  + +  L 
Sbjct: 2369 LTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLE 2428

Query: 125  Q-HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDE--DEDVQVEEAEK 181
            + + +A+   ++  ++     +E + +  +L   +    S +ND D    +  Q+EE   
Sbjct: 2429 EENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHL 2488

Query: 182  --VLESSAPREVQKAEESKVPED--SLEECAITCSNSHGPCDSN--QPHKNIN--ITFEE 233
              +LE     +   AE +K+ E+   L       ++ +   D+   Q  +++N  IT ++
Sbjct: 2489 SIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKD 2548

Query: 234  DKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNE 293
             +    L V  + +  E ++    L      S   N  +  S   L  EK +++  +  E
Sbjct: 2549 SQQKQLLEVQLQQNK-ELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS--KEIE 2605

Query: 294  KLRPQLAEKKQQFRNLKEKCF--------------VTQLAGFLANQQNKY---------- 329
             L+  +++  +Q   L+E+                V +L+   ++ Q +           
Sbjct: 2606 SLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCV 2665

Query: 330  ------KYEECEDLIKS----------MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQ 373
                  K  E ED +K           ++RNE +  EE++AE  +   E+ Q  ++V  +
Sbjct: 2666 QKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKE 2725

Query: 374  ERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE--QLAEGCRLAQHLVQ 431
             + LT   +    GR  S   N    A    DE  +     L+E  QL E   L +    
Sbjct: 2726 NKGLTAQIQSF--GRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDA 2783

Query: 432  KLSPEN-DEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCD 490
             LS      +  E+  +   EK+ +    ++ Q    S   EDS  +             
Sbjct: 2784 LLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQV------------ 2831

Query: 491  SNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPL 550
             +      ++  E D + + L   R+S   + + A        P++S   V         
Sbjct: 2832 QSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQ------PSTSPAEVQ-------- 2877

Query: 551  SSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIK 610
            S +KA  ++    ++L  +L   +QQ+  + ++  +T+L    A  Q      +   +++
Sbjct: 2878 SLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE--ITELHPLKAQLQEYQDKTKAFQIMQ 2935

Query: 611  SVLRNER--------QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 662
              LR E         Q + EK + ++ +     QY + +  ++++L+ L+  +RE R +S
Sbjct: 2936 EELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSS 2995

Query: 663  ---RSLNQHLQALLTPD---EPDKSQG-----QDLQEQLAEGCRLAQQLFQKLSPENDN 710
               + L    Q   +P+    PD SQ      + L+ QL +  +   Q   ++   N N
Sbjct: 2996 SQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSN 3054



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 152/701 (21%), Positives = 270/701 (38%), Gaps = 133/701 (18%)

Query: 33   QQFRNLKEKCFVTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEEL 92
            QQ   LKE+     +AG    +QK  ++ +  +  K  L ++   K+ +L    ++  ++
Sbjct: 1840 QQIDQLKER-----IAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM 1894

Query: 93   RQYKVLVHSQERELTQLREKLREGRD--ASRSLNQ--HLQALLTPDEPDKSQGQDLQEQL 148
                  +  +   +T+L+E   E +D    R +NQ   L   +     D +  Q   E L
Sbjct: 1895 NLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELL 1954

Query: 149  AEGCRLAQHLVQKLSPENDE--DEDEDVQVEEAEKVLE--SSAPREVQKAEESKVPEDSL 204
                +  +  V +L  E  +   E   V+ E  ++ LE    A +E      +K  ++ L
Sbjct: 1955 ESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELL 2014

Query: 205  EECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPT 264
            +E           C   Q      I+  E  V +   V  ES  D        L +    
Sbjct: 2015 KEKQQEVKQLQKDCIRYQE----KISALERTVKALEFVQTESQKD--------LEI---- 2058

Query: 265  SSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLA- 323
             +  N++  V               E  +K + +LA  K    + +     ++ A  LA 
Sbjct: 2059 -TKENLAQAV---------------EHRKKAQAELASFKVLLDDTQ-----SEAARVLAD 2097

Query: 324  NQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREK 383
            N + K + +  ++ +KS ++     K+E L  +L+QAEE        H +E++   ++EK
Sbjct: 2098 NLKLKKELQSNKESVKSQMKQ----KDEDLERRLEQAEE-------KHLKEKK--NMQEK 2144

Query: 384  LREGRDASRSLNQHLQALL-----TPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND 438
            L    DA R    HL+  +     T ++ DK + Q LQE L           + +S   D
Sbjct: 2145 L----DALRREKVHLEETIGEIQVTLNKKDK-EVQQLQENLDSTVTQLAAFTKSMSSLQD 2199

Query: 439  EDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNI 498
               D D  ++EA+K     +     K EE ++ ED+   C++               + +
Sbjct: 2200 ---DRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDN---CSVL----------KDQLRQM 2243

Query: 499  NITFEEDKVN-SALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEM 557
            +I  EE K+N S L  D++    + Q  V +      T    N  ++        E   +
Sbjct: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQL----EETRHL 2299

Query: 558  NILEMNE--KLRPQLAEKKQQFRNLK---EKC---------FVTQLACFLANQQNKYKYE 603
                 NE  KL  +L   K Q  +L    EKC          + Q    +  Q +K+ YE
Sbjct: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADI--QNSKFSYE 2357

Query: 604  ECK-DL-----IKSVLRNERQFKEEKLAEQLKQAE----------------ELRQYKVLV 641
            + + DL     + S L  E   KE+K+   L   E                E+++ + L+
Sbjct: 2358 QLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLL 2417

Query: 642  HSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQ 682
              +E E   L E+ ++  D +  L + L+ +   +   K+Q
Sbjct: 2418 SQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ 2458



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 151/772 (19%), Positives = 292/772 (37%), Gaps = 131/772 (16%)

Query: 67   IKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQH 126
            I+ ++   RQ K+E   +        ++ +  +   E+E+ +++EK+R+    ++S  Q 
Sbjct: 1632 IQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRK---FAKSKQQK 1688

Query: 127  LQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESS 186
            +  L       + +   L+ ++      A+  ++ L   N   ++E  +V+   + L   
Sbjct: 1689 ILEL-------EEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLS-- 1739

Query: 187  APREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRES 246
                 +K +     +DSL E      +           K  N+   E   N T V +  +
Sbjct: 1740 -----KKFQSLMSEKDSLSEEVQDLKHQ----IEGNVSKQANLEATEKHDNQTNVTEEGT 1790

Query: 247  SHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSE-----KAEMNILEMNEKLRPQLAE 301
                         +PG T    ++SM  S  P  SE     K+    +  +     ++  
Sbjct: 1791 Q-----------SIPGETEEQDSLSM--STRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837

Query: 302  KKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAE 361
              QQ   LKE+     +AG    +Q   ++ +  +  K+ L ++   K+ +L    ++  
Sbjct: 1838 YLQQIDQLKER-----IAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892

Query: 362  ELRQYKVLVHSQERELTQLREKLREGRD--ASRSLNQ--HLQALLTPDEPDKSQGQDLQE 417
            ++      +  +   +T+L+E   E +D    R +NQ   L   +     D +  Q   E
Sbjct: 1893 KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952

Query: 418  QLAEGCRLAQHLVQKLSPENDE--DEDEDVQVEEAEKVLE--SSAPREVQKAEESKVPED 473
             L    +  +  V +L  E  +   E   V+ E  ++ LE    A +E      +K  ++
Sbjct: 1953 LLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQE 2012

Query: 474  SLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPG 533
             L+E           C   Q      I+  E  V +   V  ES  D        L +  
Sbjct: 2013 LLKEKQQEVKQLQKDCIRYQE----KISALERTVKALEFVQTESQKD--------LEI-- 2058

Query: 534  PTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFL 593
               +  N++  V               E  +K + +LA     F+ L +           
Sbjct: 2059 ---TKENLAQAV---------------EHRKKAQAELA----SFKVLLDDTQSEAARVLA 2096

Query: 594  ANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLRE 653
             N + K + +  K+ +KS ++     K+E L  +L+QAEE        H +E++   ++E
Sbjct: 2097 DNLKLKKELQSNKESVKSQMKQ----KDEDLERRLEQAEE-------KHLKEKK--NMQE 2143

Query: 654  KLREGRDASRSLNQHLQALL-----TPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPEN 708
            KL    DA R    HL+  +     T ++ DK + Q LQE L           + +S   
Sbjct: 2144 KL----DALRREKVHLEETIGEIQVTLNKKDK-EVQQLQENLDSTVTQLAAFTKSMSSLQ 2198

Query: 709  DNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDS--------------LEECAITCS 754
            D   D D  ++ A+K ++  +     K EE  + ED+              +EE  I  S
Sbjct: 2199 D---DRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINIS 2255

Query: 755  NSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHV--EWEDAVHIIPENESD 804
                     +   +T++  ++ KV  TL G +  +  + E+  H+   ++++
Sbjct: 2256 RLEHDKQIWESKAQTEVQLQQ-KVCDTLQGENKELLSQLEETRHLYHSSQNE 2306



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 99/494 (20%), Positives = 197/494 (39%), Gaps = 81/494 (16%)

Query: 283  KAEMNILEMNEKLRPQLAEKKQQFRN-LKEKCFVTQLAGFLANQQNKYKYEECEDLIKSM 341
            K ++N+L   E+ + +  E+  +  + LK+       AG ++ ++ +++++        +
Sbjct: 932  KEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD--------L 983

Query: 342  LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
            L+ E + ++ KL   L   +EL Q    V   E EL  L+++ ++    S +    +   
Sbjct: 984  LKKENEQRKRKLQAALINRKELLQR---VSRLEEELANLKDESKKEIPLSETERGEV--- 1037

Query: 402  LTPDEPDKSQGQDLQEQLAEGCRLAQ-HLVQKLSPENDEDEDEDVQVEEAEKVLESSAPR 460
                E DK   +  ++ +   C+  + +L Q +S       +++V+++   K LE     
Sbjct: 1038 ----EEDKENKEYSEKCVTSKCQEIEIYLKQTIS-------EKEVELQHIRKDLEEKLAA 1086

Query: 461  EVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHD 520
            E Q     K    +L++             +NQ    I++   E   N A++    +S+ 
Sbjct: 1087 EEQFQALVKQMNQTLQD------------KTNQ----IDLLQAEISENQAIIQKLITSNT 1130

Query: 521  ECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNL 580
            +  D            S   V   V   P  +  +E    E+ EK+     EK+Q  + L
Sbjct: 1131 DASDG----------DSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL 1180

Query: 581  KEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKE-----EKLAEQLKQAEELR 635
            +E     +     A ++ ++  EE K       R + QF E     E + +QL+Q +   
Sbjct: 1181 QEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQV 1240

Query: 636  QYKV---LVHSQERELTQLREKLREGRDASRSLNQH-----LQALLTPDEPDKSQG---- 683
            +  +   L  + ++E       L E     ++  QH     L++ L PD P  S+     
Sbjct: 1241 RESIDGKLPSTDQQESCSSTPGLEE--PLFKATEQHHTQPVLESNLCPDWPSHSEDASAL 1298

Query: 684  ------QDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQV-EVAEKVQKSSAPREMQK- 735
                    ++ QL E      +L  K+S        +  +V ++ E++ K     E  K 
Sbjct: 1299 QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKT 1358

Query: 736  -AEEKEVPEDSLEE 748
             + E EV  +SL++
Sbjct: 1359 VSHEAEVHAESLQQ 1372



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 214/1121 (19%), Positives = 408/1121 (36%), Gaps = 225/1121 (20%)

Query: 10   SEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKYEECKDLIKF 69
            +E+ E+ IL   EK+  ++AE K  F NL+                     EE   L++ 
Sbjct: 312  TEREESKILL--EKMELEVAERKLSFHNLQ---------------------EEMHHLLE- 347

Query: 70   MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQA 129
                  QF++   A    QAE   +Y  L    + E+ +    +   +   + L     A
Sbjct: 348  ------QFEQAGQA----QAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDA 397

Query: 130  LLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDED--EDVQVEEAEKVLESSA 187
            L    + +    QD  EQ  +  +  Q L  +L  ++ E       + +++ E   ++S 
Sbjct: 398  L---KDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSF 454

Query: 188  PREVQKAEESKVPED--SLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRE 245
            P    +  ++   E+  SL++  +   N  G                   ++S  + + +
Sbjct: 455  PDVYNEGTQAVTEENIASLQKRVVELENEKGAL----------------LLSSIELEELK 498

Query: 246  SSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQ 305
            + +++    + +L     T            G    E +E++I+++  K R   AE+  Q
Sbjct: 499  AENEKLSSQITLLEAQNRT------------GEADREVSEISIVDIANK-RSSSAEESGQ 545

Query: 306  FRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQ 365
              ++ E  F               K++E   L+  M   + +    KL  Q K+AEE   
Sbjct: 546  --DVLENTF-------------SQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEE-AD 589

Query: 366  YKVLVHSQEREL-------TQLREKLRE-GRDASRSLNQHLQALLTPDEPDKSQGQDLQE 417
            ++VL   + +++        +++  L + G+D     N+       P    +    + Q 
Sbjct: 590  HEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESS---LPAVEKEQASTEHQS 646

Query: 418  QLAEGCRLAQHLVQKLSPENDEDED-------EDVQVEEAEKVLESSAPREVQKAEESKV 470
            + +E   L    V+  S + D D+             +E E++       E+   +  ++
Sbjct: 647  RTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI 706

Query: 471  PEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILP 530
             E +L+E A   S             N+N   EE K N+       ++  E +D +    
Sbjct: 707  YEKNLDEKAKEIS-------------NLNQLIEEFKKNADNNSSAFTALSEERDQL---- 749

Query: 531  VPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLA 590
                 S    +SMV         +A++  LEMN      LAE ++Q R   E    T   
Sbjct: 750  ----LSQVKELSMVTEL------RAQVKQLEMN------LAEAERQRRLDYES--QTAHD 791

Query: 591  CFLANQQNKYKYE-ECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELT 649
              L  Q +    E + KD+   VL+NE    + + +EQ            L+ S + +L 
Sbjct: 792  NLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQ----------STLIRSLQSQLQ 841

Query: 650  QLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPEND 709
                ++ EG +  R ++  ++ L       + +   + + L E  R  + L Q +  E  
Sbjct: 842  NKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTI--EEK 899

Query: 710  NDHDEDVQVEVAEKV-----QKSSAPREMQKAEE--------KEVPEDSLEECAITCSNS 756
            +    ++   + EK+     +K S   E++  +E        +E  ++ +EE     S  
Sbjct: 900  DQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGL 959

Query: 757  HGPYDSNQPH---RKTKITFEED-----------KVDSTLIGSSSHVEWEDAVHIIPENE 802
               YD   P     K ++  E D           K+ + LI     ++    +    E E
Sbjct: 960  KQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRL----EEE 1015

Query: 803  SDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSGTFHSLEEQ 862
              + ++E K  +    L E+E  EV ++  ++ YS   +  +                  
Sbjct: 1016 LANLKDESKKEIP---LSETERGEVEEDKENKEYSEKCVTSK------------------ 1054

Query: 863  QVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTD 922
              C  ++I   +    K+ + +     L  +L  E+  + L   +++     +  ++L  
Sbjct: 1055 --CQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDL-- 1110

Query: 923  SCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQ--DPSC--------PRLSRELLD- 971
              Q   S    + Q+ +    D  + +    V+E     P C        P L  ++L  
Sbjct: 1111 -LQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILAL 1169

Query: 972  EKEPEVLQDSLDRCYSTPSGYL-ELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEE 1030
            EKE E LQ  L    ++    L +  +  +  R  +   ++ Y  L    D   K+ E  
Sbjct: 1170 EKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENI 1229

Query: 1031 EDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQP 1071
             DQ        RE ++   P    D  + C STP   LE+P
Sbjct: 1230 GDQLRQLQIQVRESIDGKLPST--DQQESCSSTPG--LEEP 1266



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 126/658 (19%), Positives = 251/658 (38%), Gaps = 108/658 (16%)

Query: 328 KYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREG 387
           K+K +E E+LI ++     Q + E+ A+   + EE    K  +  +E  ++ L+ +L + 
Sbjct: 150 KHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQ- 208

Query: 388 RDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQV 447
             A ++  Q ++        +K    + Q +L E       L+Q ++       D + ++
Sbjct: 209 TQAEQAAQQVVR--------EKDARFETQVRLHE-----DELLQLVT-----QADVETEM 250

Query: 448 EEAEKVLESSAPREVQKAEESKVPE----DSLEECAITCSNSHGPCDSNQ------PHKN 497
           ++  +VL+    R++++ EES V      D L++  +T +       S Q       H  
Sbjct: 251 QQKLRVLQ----RKLEEHEESLVGRAQVVDLLQQ-ELTAAEQRNQILSQQLQQMEAEHNT 305

Query: 498 INITFEEDKVNSAL--------VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGP 549
           +  T E ++  S +        V +R+ S    Q+ ++ L           +     AG 
Sbjct: 306 LRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHL-----------LEQFEQAGQ 354

Query: 550 LSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAC-FLANQQNKYKYEECKDL 608
             +E  E     + +K + ++ EK     +L++     Q AC  L +Q +K   ++ +  
Sbjct: 355 AQAE-LESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQA 413

Query: 609 IKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLN-Q 667
           ++S      Q  E++L ++ K+  +      L   +    T   +   EG  A    N  
Sbjct: 414 VQSA--QTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIA 471

Query: 668 HLQALLTPDEPDKS----QGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDV-QVEVAE 722
            LQ  +   E +K        +L+E  AE  +L+ Q+    +     + D +V ++ + +
Sbjct: 472 SLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVD 531

Query: 723 KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYD---SNQPHRKTKITFEEDKVD 779
              K S+  E       E  +D LE    T S  H             + +I F + ++ 
Sbjct: 532 IANKRSSSAE-------ESGQDVLEN---TFSQKHKELSVLLLEMKEAQEEIAFLKLQLQ 581

Query: 780 STLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTL 839
                 + H        ++ + E    E E   P+  +   E   ++ P    +E  S+L
Sbjct: 582 GKRAEEADH-------EVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEE--SSL 632

Query: 840 SIPPEMLASYQSYSGTFHSLE---------------EQQVCMAVDIGGHRWDQVKKEDQE 884
               +  AS +  S T   +                ++ +    DIG    D++++   +
Sbjct: 633 PAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQ 692

Query: 885 ATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTD----SCQPYRSAFYILEQQR 938
                L  EL   K  E+ + +LD      S   +L +    +     SAF  L ++R
Sbjct: 693 I----LELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEER 746



 Score = 38.1 bits (87), Expect = 0.051
 Identities = 87/431 (20%), Positives = 160/431 (37%), Gaps = 49/431 (11%)

Query: 90   EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 149
            EEL + K    +  +EL QL+E+    R+    L++   ++ + +E   S  + L +QL 
Sbjct: 2752 EELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLL 2811

Query: 150  EGCRLAQHLVQKLSPENDE-----------DEDEDVQVEEAEKVLESSAPREVQKAEESK 198
                   HL  +L    ++             + D    E EK  +S   ++   A+ S 
Sbjct: 2812 SKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPST 2871

Query: 199  VPED--SLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQDAVN 256
             P +  SL++   +  N        +  KN+   + +     T +   ++   E QD   
Sbjct: 2872 SPAEVQSLKKAMSSLQNDRDRL--LKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTK 2929

Query: 257  ILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILE--MNEKLRPQLAEKKQQFRNLKEKCF 314
               +        N+S       L  EK+   I E  M E+    +++K QQ  +L+    
Sbjct: 2930 AFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQN--L 2987

Query: 315  VTQLAGFLANQQN-KYKYEECEDLIKSMLRNERQ---FKEEKLAEQLKQA-EELRQYKVL 369
            + +L    +  Q  K +Y+       S   +  Q   ++ E L  QL  + +E+ Q ++ 
Sbjct: 2988 IRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELR 3047

Query: 370  VHSQERELTQLRE-------KLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQE----- 417
            +       +QL E       +L +   + R   QH   LL      + Q Q+LQ      
Sbjct: 3048 IQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI 3107

Query: 418  QLAEGCRLAQHLVQKLSPENDEDEDED-------------VQVEEAEKVLESSAPREVQK 464
             +A G    ++ V + S   +  E +               +V E  K+LE    + V  
Sbjct: 3108 DVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAA 3167

Query: 465  AEESKVPEDSL 475
                 V E+ +
Sbjct: 3168 ENALSVAEEQI 3178



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 33/154 (21%), Positives = 72/154 (46%), Gaps = 16/154 (10%)

Query: 9    SSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKYEECKDLIK 68
            S +KA +++    ++L  +L   +QQ+  + ++  +T+L    A  Q+     +   +++
Sbjct: 2878 SLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE--ITELHPLKAQLQEYQDKTKAFQIMQ 2935

Query: 69   FMLRNER--------QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
              LR E         Q + EK + ++ +     QY + +  ++++L+ L+  +RE R +S
Sbjct: 2936 EELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSS 2995

Query: 121  ---RSLNQHLQALLTPD---EPDKSQGQDLQEQL 148
               + L    Q   +P+    PD SQ    + +L
Sbjct: 2996 SQTQPLKVQYQRQASPETSASPDGSQNLVYETEL 3029


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 197/900 (21%), Positives = 356/900 (39%), Gaps = 98/900 (10%)

Query: 9    SSEKAETNILEINEKLRPQLAENKQ--QFRNLKEKCFVTQLAGFLANRQKKYKYEECKDL 66
            +++K +  + E+  K +   AE KQ  Q R  KE+  +   +       K  + E     
Sbjct: 373  ATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGE 432

Query: 67   IKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQH 126
                L+ +RQ   EKL ++ +Q  +L+     +  Q +E      +L+   D ++  +Q 
Sbjct: 433  AHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE 492

Query: 127  LQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKL------SPEND---EDEDEDVQVE 177
             QAL         + Q+  EQ+          +Q L      S EN    E E ED+  +
Sbjct: 493  QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAK 552

Query: 178  EAEKVLESSAPREVQKAEESKVPE-DSLEECAITCSNSHGPCDSNQPHKNINITFEEDKV 236
                  E++   ++Q+   +   +   L E     S SH      Q  +N++   +E K 
Sbjct: 553  IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESH-----KQAQENLHDQVQEQKA 607

Query: 237  NSTLVVDR----ESSHDECQDAVN-----ILPVPGPTSSATNVSMVVSAGPLSSEKAEMN 287
            +     DR    E+S +E    +N     +  +     + T + +   A   +      N
Sbjct: 608  HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN 667

Query: 288  ILEMNE-----------KLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKY-----KY 331
             L+  +           K+  QL +   + ++ +E C  +QL   L   + KY     K 
Sbjct: 668  HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHC--SQLESHLKEYKEKYLSLEQKT 725

Query: 332  EECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 391
            EE E  IK +  +  + K  K  EQ  Q  +L+Q + L    E   T+L ++L   ++  
Sbjct: 726  EELEGQIKKLEADSLEVKASK--EQALQ--DLQQQRQLNTDLELRATELSKQLEMEKEIV 781

Query: 392  RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDE-----DVQ 446
             S    LQ      E  +S  Q L +Q  E   L Q   + LS E     +E        
Sbjct: 782  SSTRLDLQ---KKSEALESIKQKLTKQEEEKQILKQDF-ETLSQETKIQHEELNNRIQTT 837

Query: 447  VEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCD-SNQPHKNINITFEE- 504
            V E +KV      +E    E S V +D L + + +  NS    +  NQ  K   +  E+ 
Sbjct: 838  VTELQKV---KMEKEALMTELSTV-KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKT 893

Query: 505  -DKVNSALVVDRESSHDECQDAVNILPVPGPTS-------SATNVSMVVSAGPLSSEKAE 556
              ++   L V  E++  E ++    L      S       ++    ++ +   L   + E
Sbjct: 894  CKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953

Query: 557  MNILEMN-EKLRPQLAEKKQQFRNLKEKCFV-----TQLACFLANQQNKYKYEECKDLIK 610
               L+ N  +L+    +KK+Q   L+ +  +     T+L   L  Q  +   E   +  K
Sbjct: 954  EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK 1013

Query: 611  -SVLRNERQFKEEKLAEQLK-----QAEELRQYKVLVHSQERELTQLREKLREGRDASRS 664
             SVL+N  + K ++  +QL+     +  EL   +  + S E +L+  +E L   R+   +
Sbjct: 1014 ISVLQNNYE-KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072

Query: 665  LNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKV 724
             N+ +Q L T     +      ++QL E C+  Q + ++ S +     +E  ++   E++
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEI 1132

Query: 725  QKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIG 784
             K    +E+ K  E E+    LE    +        D+ Q   + K+   + K DS    
Sbjct: 1133 -KCRQEKEITKLNE-ELKSHKLE----SIKEITNLKDAKQLLIQQKLEL-QGKADSL--- 1182

Query: 785  SSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQ---ESEEEEVPQESWDEGYSTLSI 841
              + VE E     I +++   EEEE K     +  +   E +E+EV  +  +E  + L++
Sbjct: 1183 -KAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM 1241



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 132/676 (19%), Positives = 258/676 (38%), Gaps = 110/676 (16%)

Query: 19   EINEKLRPQLAENKQQFRNLKEKCFVTQL------AGFLANRQKKYKYEECKDLIKF--- 69
            ++N  L  +  E  +Q    KE    T+L          + +QK  K EE K ++K    
Sbjct: 758  QLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFE 817

Query: 70   MLRNERQFKEEKLAEQLKQA-EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQ 128
             L  E + + E+L  +++    EL++ K+   +   EL+ +++KL +  D+ ++      
Sbjct: 818  TLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF- 876

Query: 129  ALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAP 188
                  E +  +G+     L + C+  +H +Q +  EN   E         +K L+ S  
Sbjct: 877  ------EKENQKGKAAILDLEKTCKELKHQLQ-VQMENTLKE---------QKELKKSLE 920

Query: 189  REVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSH 248
            +E + + + K+  +S++E  I   N+                          +   E   
Sbjct: 921  KEKEASHQLKLELNSMQEQLIQAQNT--------------------------LKQNEKEE 954

Query: 249  DECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRN 308
             + Q  +N L       S+      + A     + A +   E+  KL+ QL +  Q+   
Sbjct: 955  QQLQGNINELK-----QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAA 1009

Query: 309  LKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKV 368
             KEK  V Q             YE+ ++  K  L+++   +E +L   L   ++L+    
Sbjct: 1010 EKEKISVLQ-----------NNYEKSQETFKQ-LQSDFYGRESEL---LATRQDLK---- 1050

Query: 369  LVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQH 428
               S E +L+  +E L   R+   + N+ +Q L T     +      ++QL E C+  Q 
Sbjct: 1051 ---SVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQD 1107

Query: 429  LVQKLSPENDEDEDEDVQVEEAE-----------KVLESSAPREVQKAEESKVPEDSLEE 477
            + ++ S +  E  +E  ++ E E           K+ E     +++  +E    +D+ + 
Sbjct: 1108 IQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQL 1167

Query: 478  CAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSS 537
                     G  DS      +    E++K N  ++ D+    +E      I       S 
Sbjct: 1168 LIQQKLELQGKADS------LKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSE 1221

Query: 538  ATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQ 597
                 + +     +  K  M I  +NE L     E +   R + E          L  Q 
Sbjct: 1222 IKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSE----------LEKQT 1271

Query: 598  NKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLRE 657
            +  + E    ++++ ++N +  +   L   LK   E+ + +  V   +R+L      ++E
Sbjct: 1272 DDLRGEIA--VLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQE 1329

Query: 658  -GRDASRSLNQHLQAL 672
             GR+      +H QAL
Sbjct: 1330 LGRENQSLQIKHTQAL 1345



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 99/475 (20%), Positives = 183/475 (38%), Gaps = 63/475 (13%)

Query: 277 GPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKE-KCFVTQLAGFLANQQNKYKYEECE 335
           G ++   AE+  LE       QL E + +  N+K+ K    Q A  LA         E  
Sbjct: 128 GLVTDSSAELQSLEQ------QLEEAQTENFNIKQMKDLFEQKAAQLAT--------EIA 173

Query: 336 DLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLN 395
           D IKS    ER  +E    +  +  EEL +   ++   + EL Q     R G +    L 
Sbjct: 174 D-IKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQ-----RPGIEDVAVLK 227

Query: 396 QHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQH-------LVQKLSPENDEDEDE-DVQV 447
           + L  + T  +    + +   E+L + C+  Q         + +L  E  +   E  V V
Sbjct: 228 KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287

Query: 448 EEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKV 507
           +E +K L+SS     QK +         E+        H   + +   KNI  T  +  +
Sbjct: 288 QELQK-LKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHN--EESVSKKNIQATLHQKDL 344

Query: 508 NSALVVDRESSHDECQDAVNI-LPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKL 566
           +   +  R S+ +     +++ L   G  +      +          KAE       ++L
Sbjct: 345 DCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEF------KQL 398

Query: 567 RPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAE 626
           + Q  EK+Q    L+ +  + QL   L   + +      +      L+ +RQ   EKL +
Sbjct: 399 QQQREEKEQHGLQLQSE--INQLHSKLLETERQLGEAHGR------LKEQRQLSSEKLMD 450

Query: 627 QLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDL 686
           + +Q  +L          + +L++L E+L+E    S  L   L       +  ++  Q  
Sbjct: 451 KEQQVADL----------QLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQST 500

Query: 687 QEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAEEKEV 741
             +L E     +Q+ +++      D D+ +Q  +   +QKS     + + E +++
Sbjct: 501 TAKLREAQNDLEQVLRQI-----GDKDQKIQ-NLEALLQKSKENISLLEKEREDL 549


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 148/696 (21%), Positives = 280/696 (40%), Gaps = 109/696 (15%)

Query: 34   QFRNLKEKCFVTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAE-------QL 86
            Q + L+ KC   + A    N  K +K +   + +  ML NE + K  KLA+       QL
Sbjct: 1260 QVQELQSKCSDGERARAELN-DKVHKLQNEVESVTGML-NEAEGKAIKLAKDVASLSSQL 1317

Query: 87   KQAEELRQ----YKVLVHSQERELTQ----LREKLREGRDASRSLNQHLQALLTPDEPDK 138
            +  +EL Q     K+ V ++ R+L +    L+++L E  +A ++L +H+  L       K
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377

Query: 139  SQGQDLQ---EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAE 195
             + QD     E L EG +  Q  ++ L+ + +E      ++E+ +  L+      V   +
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437

Query: 196  ESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQDA- 254
              +    +LE+               +  K   +  EE  ++S    +R+ +  E ++  
Sbjct: 1438 NQRQLVSNLEK---------------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 255  VNILPVPGPTSSA---------TNVSMVVSAGPLSSEKAEM--NILEMNEK---LRPQLA 300
               L +      A         TN  +      L S K ++  N+ E+ +    L  Q+ 
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 301  EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA 360
            E K Q   L+++   T+ A        K + E     +K     + Q ++E+        
Sbjct: 1543 EMKTQLEELEDELQATEDA--------KLRLEVNMQALKGQFERDLQARDEQ------NE 1588

Query: 361  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL-LTPDEPDK---------- 409
            E+ RQ +  +H  E EL   R++      A + L   L+ L L  D   K          
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648

Query: 410  ---SQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDE-DVQVEEAEKVLESSAPREVQKA 465
               +Q +D Q +L E  R ++  +   + EN++     +  + + ++ L ++A R  ++A
Sbjct: 1649 KLQAQMKDFQREL-EDARASRDEIFATAKENEKKAKSLEADLMQLQEDL-AAAERARKQA 1706

Query: 466  EESKVPEDSLEECAITCSNSHGPCDSNQPHK----NINITFEEDKVNSALVVDR-ESSHD 520
            +  K  E+  EE A + S  +   D  +  +     +    EE++ N   + DR   +  
Sbjct: 1707 DLEK--EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764

Query: 521  ECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNL 580
            + +   N L     T+               +E A   +   N++LR +L E +   ++ 
Sbjct: 1765 QAEQLSNELATERSTAQ-------------KNESARQQLERQNKELRSKLHEMEGAVKS- 1810

Query: 581  KEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELR----Q 636
            K K  +  L   +A  + + + E  +   K       + K++KL E L Q E+ R    Q
Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQEARE---KQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867

Query: 637  YKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 672
            YK         + QL+ +L E  + S+ +N + + L
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 174/867 (20%), Positives = 331/867 (38%), Gaps = 145/867 (16%)

Query: 12   KAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYK--YEECKDLIKF 69
            +AET +    E++R +LA  KQ+   +     + ++   L   + + +    E K + + 
Sbjct: 897  QAETELYAEAEEMRVRLAAKKQELEEI-----LHEMEARLEEEEDRGQQLQAERKKMAQQ 951

Query: 70   MLRNERQFKEEKLAEQLKQAEELR--------QYKVLVH-------SQEREL-------- 106
            ML  E Q +EE+ A Q  Q E++         + ++LV        S+ER+L        
Sbjct: 952  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011

Query: 107  -TQLREKLREGRDASRSLNQH------LQALLTPDEPDKSQ-----------GQDLQEQL 148
             T L E+  + ++ ++  N+H      L+  L  +E  + +             D  EQ+
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071

Query: 149  AEGCRLAQHLVQKLSPENDE-------DEDEDVQVEEAEKVL-----------ESSAPRE 190
            A+       L  +L+ + +E        +DE  Q   A K +           E      
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131

Query: 191  VQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDE 250
              + +  K   D  EE     +      DS    + +    E++       +D E+   E
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191

Query: 251  CQ---------DAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEM-NILEMNEKLRPQLA 300
             Q          AV  L            ++  +   L  E A++   L +  + + ++ 
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251

Query: 301  EKKQ----QFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAE- 355
             KK+    Q + L+ KC   + A    N +  +K +   + +  ML NE + K  KLA+ 
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGML-NEAEGKAIKLAKD 1309

Query: 356  ------QLKQAEELRQ----YKVLVHSQERELTQ----LREKLREGRDASRSLNQHLQAL 401
                  QL+  +EL Q     K+ V ++ R+L +    L+++L E  +A ++L +H+  L
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369

Query: 402  LTPDEPDKSQGQDLQ---EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSA 458
                   K + QD     E L EG +  Q  ++ L+ + +E          A   LE + 
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK-------AAAYDKLEKTK 1422

Query: 459  PREVQKAEESKVPEDSLEECAITCSNSHGPCDS-NQPHKNINITFEEDKVNS-ALVVDRE 516
             R  Q+ ++  V  D+  +            D      KNI+  + +++  + A   ++E
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 517  SSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEM--NILEMNEK---LRPQLA 571
            +       A+            TN  +      L S K ++  N+ E+ +    L  Q+ 
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 572  EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQA 631
            E K Q   L+++   T+ A        K + E     +K       QF+ +  A   +  
Sbjct: 1543 EMKTQLEELEDELQATEDA--------KLRLEVNMQALKG------QFERDLQARDEQNE 1588

Query: 632  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL-LTPDEPDK---------- 680
            E+ RQ +  +H  E EL   R++      A + L   L+ L L  D   K          
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648

Query: 681  ---SQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAE 737
               +Q +D Q +L +      ++F   + + +    + ++ ++ +  +  +A    +K  
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIF--ATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1706

Query: 738  EKEVPEDSLEECAITCSNSHGPYDSNQ 764
            + E  E+  EE A + S  +   D  +
Sbjct: 1707 DLE-KEELAEELASSLSGRNALQDEKR 1732



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 154/798 (19%), Positives = 299/798 (37%), Gaps = 105/798 (13%)

Query: 74   ERQFK-EEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLT 132
            ERQ K E +L E  ++  +L + K L+  Q +  T+L  +  E R    +  Q L+ +L 
Sbjct: 866  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925

Query: 133  PDEPDKSQGQDLQEQL-AEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREV 191
              E    + +D  +QL AE  ++AQ ++     E  E+E+   Q  + EKV   +A  ++
Sbjct: 926  EMEARLEEEEDRGQQLQAERKKMAQQMLD--LEEQLEEEEAARQKLQLEKV---TAEAKI 980

Query: 192  QKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDEC 251
            +K E+  +  D         S      +        N+  EE+K  +  +   ++ H+  
Sbjct: 981  KKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEEEEKAKN--LTKLKNKHESM 1035

Query: 252  QDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKE 311
               + +                        EK+   + ++  KL    ++  +Q  +L+ 
Sbjct: 1036 ISELEV-------------------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076

Query: 312  KCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVH 371
            +  + +L   LA ++        E+L  ++ R      ++++A++    +++R+ +  + 
Sbjct: 1077 Q--IAELKMQLAKKE--------EELQAALAR-----LDDEIAQKNNALKKIRELEGHIS 1121

Query: 372  SQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQ 431
              + +L   R    +     R L + L+AL T  E D       Q++L    +  Q +  
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-DTLDSTATQQELR--AKREQEVTV 1178

Query: 432  KLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSH----- 486
                 ++E    + QV+E  +    +     ++ E+ K  + +L++   T    +     
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238

Query: 487  -----GPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNV 541
                 G       HK   +  +  ++ S    D E +  E  D V+ L       S T +
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSK-CSDGERARAELNDKVHKL--QNEVESVTGM 1295

Query: 542  SMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYK 601
                    +   K   ++    +  +  L E+ +Q  N+  K  + QL     + Q++  
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK--LRQLEEERNSLQDQLD 1353

Query: 602  YE-ECKDLIK---SVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLRE 657
             E E K  ++   S L  +    ++KL +     E L + K     +   LTQ  E+   
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413

Query: 658  GRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDN------D 711
              D        LQ  L     D     D Q QL       Q+ F +L  E  N      D
Sbjct: 1414 AYDKLEKTKNRLQQEL----DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 712  HDEDVQVEVAEKVQKS-----------------SAPREMQKAEEKEV--PEDSLEECAIT 752
              +  + E  EK  K+                     +M KAE +++   +D + +    
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529

Query: 753  CSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIP-----ENESDDEE 807
               S    ++     KT++   ED++ +T     + +  E  +  +      + ++ DE+
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQAT---EDAKLRLEVNMQALKGQFERDLQARDEQ 1586

Query: 808  EEEKGPVSPRNLQESEEE 825
             EEK     R L E E E
Sbjct: 1587 NEEKRRQLQRQLHEYETE 1604



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 148/754 (19%), Positives = 275/754 (36%), Gaps = 130/754 (17%)

Query: 345  ERQFK-EEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLT 403
            ERQ K E +L E  ++  +L + K L+  Q +  T+L  +  E R    +  Q L+ +L 
Sbjct: 866  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925

Query: 404  PDEPDKSQGQDLQEQL-AEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREV 462
              E    + +D  +QL AE  ++AQ ++     E  E+E+   Q  + EKV   +A  ++
Sbjct: 926  EMEARLEEEEDRGQQLQAERKKMAQQMLD--LEEQLEEEEAARQKLQLEKV---TAEAKI 980

Query: 463  QKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDEC 522
            +K E+  +  D         S      +        N+  EE+K  +  +   ++ H+  
Sbjct: 981  KKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEEEEKAKN--LTKLKNKHESM 1035

Query: 523  QDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKE 582
               + +                        EK+   + ++  KL    ++  +Q  +L+ 
Sbjct: 1036 ISELEV-------------------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076

Query: 583  KCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVH 642
            +  + +L   LA      K EE +  +  +        ++++A++    +++R+ +  + 
Sbjct: 1077 Q--IAELKMQLAK-----KEEELQAALARL--------DDEIAQKNNALKKIRELEGHIS 1121

Query: 643  SQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQ 702
              + +L   R    +     R L + L+AL T  E D       Q++L         + +
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-DTLDSTATQQELRAKREQEVTVLK 1180

Query: 703  KLSPENDNDHDEDVQ-------------VEVAEKVQKSSAPREMQKAEEKEVPEDSLEEC 749
            K   E    H+  VQ              E  E+ +++ A  +  K   ++   D   E 
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240

Query: 750  AITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLI-GSSSHVEWEDAVHIIPE-------- 800
             +      G       H+K K+  +  ++ S    G  +  E  D VH +          
Sbjct: 1241 RVL-----GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295

Query: 801  -NESD------------------------DEEEEEKGPVSPRNLQESEEEEVPQESWDE- 834
             NE++                         EE  +K  VS +  Q  EE    Q+  DE 
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355

Query: 835  ---------GYSTLSIP-PEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQE 884
                       STL+I   +     Q ++ T  +LEE +     +I        + E++ 
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL---TQQYEEKA 1412

Query: 885  ATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAF--YILEQQRVG-- 940
            A   +L      EK    LQ  LD          +L  + +  +  F   + E++ +   
Sbjct: 1413 AAYDKL------EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466

Query: 941  WALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLE-LPDLG 999
            +A + D  E     +E +  S  R   E L+ KE       L+R        +E L    
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKE------ELERTNKMLKAEMEDLVSSK 1520

Query: 1000 QPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQ 1033
                  V+ LE+    L   ++ +K   EE ED+
Sbjct: 1521 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 90/420 (21%), Positives = 169/420 (40%), Gaps = 62/420 (14%)

Query: 9    SSEKAETNILEINEK---LRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKYEECKD 65
            S +    N+ E+ +    L  Q+ E K Q   L+++   T+ A        K + E    
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA--------KLRLEVNMQ 1570

Query: 66   LIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQ 125
             +K     + Q ++E+        E+ RQ +  +H  E EL   R++      A + L  
Sbjct: 1571 ALKGQFERDLQARDEQ------NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624

Query: 126  HLQAL-LTPDEPDK-------------SQGQDLQEQLAEGCRLAQHLVQKLSPENDEDED 171
             L+ L L  D   K             +Q +D Q +L E  R ++  +   + EN++   
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL-EDARASRDEIFATAKENEKKAK 1683

Query: 172  E-DVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK----N 226
              +  + + ++ L ++A R  ++A+  K  E+  EE A + S  +   D  +  +     
Sbjct: 1684 SLEADLMQLQEDL-AAAERARKQADLEK--EELAEELASSLSGRNALQDEKRRLEARIAQ 1740

Query: 227  INITFEEDKVNSTLVVDR-ESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAE 285
            +    EE++ N   + DR   +  + +   N L     T+               +E A 
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ-------------KNESAR 1787

Query: 286  MNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNE 345
              +   N++LR +L E +   ++ K K  +  L   +A  + + + E  E   K      
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKS-KFKSTIAALEAKIAQLEEQVEQEARE---KQAATKS 1843

Query: 346  RQFKEEKLAEQLKQAEELR----QYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             + K++KL E L Q E+ R    QYK         + QL+ +L E  + S+ +N + + L
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 148/696 (21%), Positives = 280/696 (40%), Gaps = 109/696 (15%)

Query: 34   QFRNLKEKCFVTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAE-------QL 86
            Q + L+ KC   + A    N  K +K +   + +  ML NE + K  KLA+       QL
Sbjct: 1267 QVQELQSKCSDGERARAELN-DKVHKLQNEVESVTGML-NEAEGKAIKLAKDVASLSSQL 1324

Query: 87   KQAEELRQ----YKVLVHSQERELTQ----LREKLREGRDASRSLNQHLQALLTPDEPDK 138
            +  +EL Q     K+ V ++ R+L +    L+++L E  +A ++L +H+  L       K
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384

Query: 139  SQGQDLQ---EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAE 195
             + QD     E L EG +  Q  ++ L+ + +E      ++E+ +  L+      V   +
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444

Query: 196  ESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQDA- 254
              +    +LE+               +  K   +  EE  ++S    +R+ +  E ++  
Sbjct: 1445 NQRQLVSNLEK---------------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 255  VNILPVPGPTSSA---------TNVSMVVSAGPLSSEKAEM--NILEMNEK---LRPQLA 300
               L +      A         TN  +      L S K ++  N+ E+ +    L  Q+ 
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 301  EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA 360
            E K Q   L+++   T+ A        K + E     +K     + Q ++E+        
Sbjct: 1550 EMKTQLEELEDELQATEDA--------KLRLEVNMQALKGQFERDLQARDEQ------NE 1595

Query: 361  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL-LTPDEPDK---------- 409
            E+ RQ +  +H  E EL   R++      A + L   L+ L L  D   K          
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655

Query: 410  ---SQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDE-DVQVEEAEKVLESSAPREVQKA 465
               +Q +D Q +L E  R ++  +   + EN++     +  + + ++ L ++A R  ++A
Sbjct: 1656 KLQAQMKDFQREL-EDARASRDEIFATAKENEKKAKSLEADLMQLQEDL-AAAERARKQA 1713

Query: 466  EESKVPEDSLEECAITCSNSHGPCDSNQPHK----NINITFEEDKVNSALVVDR-ESSHD 520
            +  K  E+  EE A + S  +   D  +  +     +    EE++ N   + DR   +  
Sbjct: 1714 DLEK--EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771

Query: 521  ECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNL 580
            + +   N L     T+               +E A   +   N++LR +L E +   ++ 
Sbjct: 1772 QAEQLSNELATERSTAQ-------------KNESARQQLERQNKELRSKLHEMEGAVKS- 1817

Query: 581  KEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELR----Q 636
            K K  +  L   +A  + + + E  +   K       + K++KL E L Q E+ R    Q
Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQEARE---KQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874

Query: 637  YKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 672
            YK         + QL+ +L E  + S+ +N + + L
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 174/867 (20%), Positives = 331/867 (38%), Gaps = 145/867 (16%)

Query: 12   KAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYK--YEECKDLIKF 69
            +AET +    E++R +LA  KQ+   +     + ++   L   + + +    E K + + 
Sbjct: 904  QAETELYAEAEEMRVRLAAKKQELEEI-----LHEMEARLEEEEDRGQQLQAERKKMAQQ 958

Query: 70   MLRNERQFKEEKLAEQLKQAEELR--------QYKVLVH-------SQEREL-------- 106
            ML  E Q +EE+ A Q  Q E++         + ++LV        S+ER+L        
Sbjct: 959  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018

Query: 107  -TQLREKLREGRDASRSLNQH------LQALLTPDEPDKSQ-----------GQDLQEQL 148
             T L E+  + ++ ++  N+H      L+  L  +E  + +             D  EQ+
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078

Query: 149  AEGCRLAQHLVQKLSPENDE-------DEDEDVQVEEAEKVL-----------ESSAPRE 190
            A+       L  +L+ + +E        +DE  Q   A K +           E      
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138

Query: 191  VQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDE 250
              + +  K   D  EE     +      DS    + +    E++       +D E+   E
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198

Query: 251  CQ---------DAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEM-NILEMNEKLRPQLA 300
             Q          AV  L            ++  +   L  E A++   L +  + + ++ 
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258

Query: 301  EKKQ----QFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAE- 355
             KK+    Q + L+ KC   + A    N +  +K +   + +  ML NE + K  KLA+ 
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGML-NEAEGKAIKLAKD 1316

Query: 356  ------QLKQAEELRQ----YKVLVHSQERELTQ----LREKLREGRDASRSLNQHLQAL 401
                  QL+  +EL Q     K+ V ++ R+L +    L+++L E  +A ++L +H+  L
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376

Query: 402  LTPDEPDKSQGQDLQ---EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSA 458
                   K + QD     E L EG +  Q  ++ L+ + +E          A   LE + 
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK-------AAAYDKLEKTK 1429

Query: 459  PREVQKAEESKVPEDSLEECAITCSNSHGPCDS-NQPHKNINITFEEDKVNS-ALVVDRE 516
             R  Q+ ++  V  D+  +            D      KNI+  + +++  + A   ++E
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 517  SSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEM--NILEMNEK---LRPQLA 571
            +       A+            TN  +      L S K ++  N+ E+ +    L  Q+ 
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 572  EKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQA 631
            E K Q   L+++   T+ A        K + E     +K       QF+ +  A   +  
Sbjct: 1550 EMKTQLEELEDELQATEDA--------KLRLEVNMQALKG------QFERDLQARDEQNE 1595

Query: 632  EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL-LTPDEPDK---------- 680
            E+ RQ +  +H  E EL   R++      A + L   L+ L L  D   K          
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655

Query: 681  ---SQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAPREMQKAE 737
               +Q +D Q +L +      ++F   + + +    + ++ ++ +  +  +A    +K  
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIF--ATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1713

Query: 738  EKEVPEDSLEECAITCSNSHGPYDSNQ 764
            + E  E+  EE A + S  +   D  +
Sbjct: 1714 DLE-KEELAEELASSLSGRNALQDEKR 1739



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 154/798 (19%), Positives = 299/798 (37%), Gaps = 105/798 (13%)

Query: 74   ERQFK-EEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLT 132
            ERQ K E +L E  ++  +L + K L+  Q +  T+L  +  E R    +  Q L+ +L 
Sbjct: 873  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932

Query: 133  PDEPDKSQGQDLQEQL-AEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREV 191
              E    + +D  +QL AE  ++AQ ++     E  E+E+   Q  + EKV   +A  ++
Sbjct: 933  EMEARLEEEEDRGQQLQAERKKMAQQMLD--LEEQLEEEEAARQKLQLEKV---TAEAKI 987

Query: 192  QKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDEC 251
            +K E+  +  D         S      +        N+  EE+K  +  +   ++ H+  
Sbjct: 988  KKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEEEEKAKN--LTKLKNKHESM 1042

Query: 252  QDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKE 311
               + +                        EK+   + ++  KL    ++  +Q  +L+ 
Sbjct: 1043 ISELEV-------------------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083

Query: 312  KCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVH 371
            +  + +L   LA ++        E+L  ++ R      ++++A++    +++R+ +  + 
Sbjct: 1084 Q--IAELKMQLAKKE--------EELQAALAR-----LDDEIAQKNNALKKIRELEGHIS 1128

Query: 372  SQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQ 431
              + +L   R    +     R L + L+AL T  E D       Q++L    +  Q +  
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-DTLDSTATQQELR--AKREQEVTV 1185

Query: 432  KLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSH----- 486
                 ++E    + QV+E  +    +     ++ E+ K  + +L++   T    +     
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245

Query: 487  -----GPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNV 541
                 G       HK   +  +  ++ S    D E +  E  D V+ L       S T +
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSK-CSDGERARAELNDKVHKL--QNEVESVTGM 1302

Query: 542  SMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYK 601
                    +   K   ++    +  +  L E+ +Q  N+  K  + QL     + Q++  
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK--LRQLEEERNSLQDQLD 1360

Query: 602  YE-ECKDLIK---SVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLRE 657
             E E K  ++   S L  +    ++KL +     E L + K     +   LTQ  E+   
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420

Query: 658  GRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDN------D 711
              D        LQ  L     D     D Q QL       Q+ F +L  E  N      D
Sbjct: 1421 AYDKLEKTKNRLQQEL----DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 712  HDEDVQVEVAEKVQKS-----------------SAPREMQKAEEKEV--PEDSLEECAIT 752
              +  + E  EK  K+                     +M KAE +++   +D + +    
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536

Query: 753  CSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIP-----ENESDDEE 807
               S    ++     KT++   ED++ +T     + +  E  +  +      + ++ DE+
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQAT---EDAKLRLEVNMQALKGQFERDLQARDEQ 1593

Query: 808  EEEKGPVSPRNLQESEEE 825
             EEK     R L E E E
Sbjct: 1594 NEEKRRQLQRQLHEYETE 1611



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 148/754 (19%), Positives = 275/754 (36%), Gaps = 130/754 (17%)

Query: 345  ERQFK-EEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLT 403
            ERQ K E +L E  ++  +L + K L+  Q +  T+L  +  E R    +  Q L+ +L 
Sbjct: 873  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932

Query: 404  PDEPDKSQGQDLQEQL-AEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREV 462
              E    + +D  +QL AE  ++AQ ++     E  E+E+   Q  + EKV   +A  ++
Sbjct: 933  EMEARLEEEEDRGQQLQAERKKMAQQMLD--LEEQLEEEEAARQKLQLEKV---TAEAKI 987

Query: 463  QKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDEC 522
            +K E+  +  D         S      +        N+  EE+K  +  +   ++ H+  
Sbjct: 988  KKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEEEEKAKN--LTKLKNKHESM 1042

Query: 523  QDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKE 582
               + +                        EK+   + ++  KL    ++  +Q  +L+ 
Sbjct: 1043 ISELEV-------------------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083

Query: 583  KCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVH 642
            +  + +L   LA      K EE +  +  +        ++++A++    +++R+ +  + 
Sbjct: 1084 Q--IAELKMQLAK-----KEEELQAALARL--------DDEIAQKNNALKKIRELEGHIS 1128

Query: 643  SQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQ 702
              + +L   R    +     R L + L+AL T  E D       Q++L         + +
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-DTLDSTATQQELRAKREQEVTVLK 1187

Query: 703  KLSPENDNDHDEDVQ-------------VEVAEKVQKSSAPREMQKAEEKEVPEDSLEEC 749
            K   E    H+  VQ              E  E+ +++ A  +  K   ++   D   E 
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247

Query: 750  AITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLI-GSSSHVEWEDAVHIIPE-------- 800
             +      G       H+K K+  +  ++ S    G  +  E  D VH +          
Sbjct: 1248 RVL-----GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302

Query: 801  -NESD------------------------DEEEEEKGPVSPRNLQESEEEEVPQESWDE- 834
             NE++                         EE  +K  VS +  Q  EE    Q+  DE 
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362

Query: 835  ---------GYSTLSIP-PEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQE 884
                       STL+I   +     Q ++ T  +LEE +     +I        + E++ 
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL---TQQYEEKA 1419

Query: 885  ATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAF--YILEQQRVG-- 940
            A   +L      EK    LQ  LD          +L  + +  +  F   + E++ +   
Sbjct: 1420 AAYDKL------EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1473

Query: 941  WALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLE-LPDLG 999
            +A + D  E     +E +  S  R   E L+ KE       L+R        +E L    
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKE------ELERTNKMLKAEMEDLVSSK 1527

Query: 1000 QPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQ 1033
                  V+ LE+    L   ++ +K   EE ED+
Sbjct: 1528 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 90/420 (21%), Positives = 169/420 (40%), Gaps = 62/420 (14%)

Query: 9    SSEKAETNILEINEK---LRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKYEECKD 65
            S +    N+ E+ +    L  Q+ E K Q   L+++   T+ A        K + E    
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA--------KLRLEVNMQ 1577

Query: 66   LIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQ 125
             +K     + Q ++E+        E+ RQ +  +H  E EL   R++      A + L  
Sbjct: 1578 ALKGQFERDLQARDEQ------NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631

Query: 126  HLQAL-LTPDEPDK-------------SQGQDLQEQLAEGCRLAQHLVQKLSPENDEDED 171
             L+ L L  D   K             +Q +D Q +L E  R ++  +   + EN++   
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL-EDARASRDEIFATAKENEKKAK 1690

Query: 172  E-DVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHK----N 226
              +  + + ++ L ++A R  ++A+  K  E+  EE A + S  +   D  +  +     
Sbjct: 1691 SLEADLMQLQEDL-AAAERARKQADLEK--EELAEELASSLSGRNALQDEKRRLEARIAQ 1747

Query: 227  INITFEEDKVNSTLVVDR-ESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAE 285
            +    EE++ N   + DR   +  + +   N L     T+               +E A 
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ-------------KNESAR 1794

Query: 286  MNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNE 345
              +   N++LR +L E +   ++ K K  +  L   +A  + + + E  E   K      
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKS-KFKSTIAALEAKIAQLEEQVEQEARE---KQAATKS 1850

Query: 346  RQFKEEKLAEQLKQAEELR----QYKVLVHSQERELTQLREKLREGRDASRSLNQHLQAL 401
             + K++KL E L Q E+ R    QYK         + QL+ +L E  + S+ +N + + L
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.128    0.358 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,521,417
Number of Sequences: 37866
Number of extensions: 2610064
Number of successful extensions: 25839
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 119
Number of HSP's successfully gapped in prelim test: 884
Number of HSP's that attempted gapping in prelim test: 15389
Number of HSP's gapped (non-prelim): 7365
length of query: 1214
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1100
effective length of database: 13,930,794
effective search space: 15323873400
effective search space used: 15323873400
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.