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Search of human proteins with 90970328
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|90970328 R-spondin family, member 4 isoform 2 precursor
[Homo sapiens]
(172 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|90970328 R-spondin family, member 4 isoform 2 precursor [Homo... 375 e-104
gi|83722284 R-spondin family, member 4 isoform 1 precursor [Homo... 313 4e-86
gi|222446611 R-spondin family, member 2 [Homo sapiens] 146 1e-35
gi|84490388 R-spondin1 [Homo sapiens] 127 4e-30
gi|18490982 R-spondin 3 [Homo sapiens] 127 5e-30
gi|20336184 paired basic amino acid cleaving system 4 isoform h ... 58 4e-09
gi|20336182 paired basic amino acid cleaving system 4 isoform g ... 58 4e-09
gi|4505577 paired basic amino acid cleaving system 4 isoform a p... 58 4e-09
gi|20336180 paired basic amino acid cleaving system 4 isoform b ... 58 4e-09
gi|239755070 PREDICTED: similar to proprotein convertase subtili... 57 1e-08
gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo ... 55 2e-08
gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo ... 55 2e-08
gi|108773804 Fraser syndrome 1 [Homo sapiens] 54 5e-08
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro... 54 9e-08
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 39 0.002
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 39 0.002
gi|14790170 tumor necrosis factor receptor superfamily, member 6... 39 0.003
gi|145309326 laminin, gamma 1 precursor [Homo sapiens] 39 0.003
gi|4507585 tumor necrosis factor receptor superfamily, member 6b... 39 0.003
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens] 39 0.003
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 38 0.004
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 38 0.004
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 37 0.006
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 37 0.011
gi|111125011 WNT inhibitory factor 1 precursor [Homo sapiens] 35 0.024
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s... 35 0.024
gi|19743803 fibulin 5 precursor [Homo sapiens] 35 0.032
gi|110347437 latent transforming growth factor beta binding prot... 35 0.032
gi|110347412 latent transforming growth factor beta binding prot... 35 0.032
gi|110347431 latent transforming growth factor beta binding prot... 35 0.032
>gi|90970328 R-spondin family, member 4 isoform 2 precursor [Homo
sapiens]
Length = 172
Score = 375 bits (963), Expect = e-104
Identities = 172/172 (100%), Positives = 172/172 (100%)
Query: 1 MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR 60
MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR
Sbjct: 1 MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR 60
Query: 61 EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP 120
EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP
Sbjct: 61 EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP 120
Query: 121 TCPPGTLAHQNTRECQERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP 172
TCPPGTLAHQNTRECQERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP
Sbjct: 121 TCPPGTLAHQNTRECQERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP 172
>gi|83722284 R-spondin family, member 4 isoform 1 precursor [Homo
sapiens]
Length = 234
Score = 313 bits (803), Expect = 4e-86
Identities = 161/234 (68%), Positives = 164/234 (70%), Gaps = 62/234 (26%)
Query: 1 MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR 60
MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR
Sbjct: 1 MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR 60
Query: 61 EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP 120
EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP
Sbjct: 61 EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP 120
Query: 121 TCPPGTLAHQNTRECQ-------------------------------------------- 136
TCPPGTLAHQNTRECQ
Sbjct: 121 TCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAAT 180
Query: 137 -------ERSPGQKKGRKDRRP-----RKD------RKLDRRLDVRPRQPGLQP 172
+ P Q+ +R P RKD RKLDRRLDVRPRQPGLQP
Sbjct: 181 CQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP 234
>gi|222446611 R-spondin family, member 2 [Homo sapiens]
Length = 243
Score = 146 bits (368), Expect = 1e-35
Identities = 61/117 (52%), Positives = 80/117 (68%), Gaps = 1/117 (0%)
Query: 22 RRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIR 81
RR K+ C GC+ CS++NGCS CQQ+LF F+RREG+RQYG+CLH CP GY+G R
Sbjct: 27 RRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHR 86
Query: 82 GQEVNRCKKCG-ATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQE 137
++NRC +C C+SCFS+DFC +CK FYL++G+C CP G + T EC E
Sbjct: 87 APDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVE 143
>gi|84490388 R-spondin1 [Homo sapiens]
Length = 263
Score = 127 bits (320), Expect = 4e-30
Identities = 63/149 (42%), Positives = 84/149 (56%), Gaps = 9/149 (6%)
Query: 1 MRAPLCLLLLVAHAVDMLALNR-----RKKQVGTGLGGNCT-GCIICSEENGCSTCQQRL 54
MR LC++ LV + +R R++++ C GC +CSE NGC C +L
Sbjct: 1 MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL 60
Query: 55 FLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGAT-CESCFSQDFCIRCKRQFYL 113
F+ + R IRQ G CL CPPGYF R ++N+C KC CE+CFS +FC +CK YL
Sbjct: 61 FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYL 120
Query: 114 YKGKCLPTCPPGTLAHQNTRECQERSPGQ 142
+KG+C P CP G+ A T EC SP Q
Sbjct: 121 HKGRCYPACPEGSSAANGTMECS--SPAQ 147
>gi|18490982 R-spondin 3 [Homo sapiens]
Length = 272
Score = 127 bits (319), Expect = 5e-30
Identities = 52/115 (45%), Positives = 76/115 (66%), Gaps = 1/115 (0%)
Query: 22 RRKKQVGTGLGGNCTG-CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGI 80
RR++++ + C G C CS+ NGC +C+ RLF + R G++Q G CL CP GY+G
Sbjct: 28 RRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGT 87
Query: 81 RGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTREC 135
R ++N+C KC A C++CF+++FC +CK FYL+ GKCL CP G A+ +T EC
Sbjct: 88 RYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMEC 142
>gi|20336184 paired basic amino acid cleaving system 4 isoform h
preproprotein [Homo sapiens]
Length = 962
Score = 58.2 bits (139), Expect = 4e-09
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 6/81 (7%)
Query: 68 KCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDF--CIRCKRQFYLYK--GKCLPTCP 123
KC+ CP GYFG RC++C CE+C S+ C+ C+R FY ++ C+ CP
Sbjct: 715 KCVSVCPLGYFG--DTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCP 772
Query: 124 PGTLAHQNTRECQERSPGQKK 144
G A ++ + C + P KK
Sbjct: 773 AGFYADESQKNCLKCHPSCKK 793
Score = 56.6 bits (135), Expect = 1e-08
Identities = 31/98 (31%), Positives = 43/98 (43%), Gaps = 8/98 (8%)
Query: 46 GCSTCQQRLFL--FIRREGI---RQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFS 100
GC TC R R G ++ C+ CP G++ Q+ C KC +C+ C
Sbjct: 739 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQK--NCLKCHPSCKKCVD 796
Query: 101 Q-DFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQE 137
+ + C CK F L +G C+P C PGT C E
Sbjct: 797 EPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGE 834
Score = 54.3 bits (129), Expect = 5e-08
Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 16/95 (16%)
Query: 34 NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPG-YFGIRGQEVNRCKKCG 92
+C C+ E C+ C++ L G C+ DC PG YF E+ RC +C
Sbjct: 790 SCKKCV--DEPEKCTVCKEGFSL--------ARGSCIPDCEPGTYFD---SELIRCGECH 836
Query: 93 ATCESCFS--QDFCIRCKRQFYLYKGKCLPTCPPG 125
TC +C ++ CI C + F+ + KC+P C G
Sbjct: 837 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 871
>gi|20336182 paired basic amino acid cleaving system 4 isoform g
preproprotein [Homo sapiens]
Length = 975
Score = 58.2 bits (139), Expect = 4e-09
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 6/81 (7%)
Query: 68 KCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDF--CIRCKRQFYLYK--GKCLPTCP 123
KC+ CP GYFG RC++C CE+C S+ C+ C+R FY ++ C+ CP
Sbjct: 728 KCVSVCPLGYFG--DTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCP 785
Query: 124 PGTLAHQNTRECQERSPGQKK 144
G A ++ + C + P KK
Sbjct: 786 AGFYADESQKNCLKCHPSCKK 806
Score = 56.6 bits (135), Expect = 1e-08
Identities = 31/98 (31%), Positives = 43/98 (43%), Gaps = 8/98 (8%)
Query: 46 GCSTCQQRLFL--FIRREGI---RQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFS 100
GC TC R R G ++ C+ CP G++ Q+ C KC +C+ C
Sbjct: 752 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQK--NCLKCHPSCKKCVD 809
Query: 101 Q-DFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQE 137
+ + C CK F L +G C+P C PGT C E
Sbjct: 810 EPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGE 847
Score = 54.3 bits (129), Expect = 5e-08
Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 16/95 (16%)
Query: 34 NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPG-YFGIRGQEVNRCKKCG 92
+C C+ E C+ C++ L G C+ DC PG YF E+ RC +C
Sbjct: 803 SCKKCV--DEPEKCTVCKEGFSL--------ARGSCIPDCEPGTYFD---SELIRCGECH 849
Query: 93 ATCESCFS--QDFCIRCKRQFYLYKGKCLPTCPPG 125
TC +C ++ CI C + F+ + KC+P C G
Sbjct: 850 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 884
>gi|4505577 paired basic amino acid cleaving system 4 isoform a
preproprotein [Homo sapiens]
Length = 969
Score = 58.2 bits (139), Expect = 4e-09
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 6/81 (7%)
Query: 68 KCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDF--CIRCKRQFYLYK--GKCLPTCP 123
KC+ CP GYFG RC++C CE+C S+ C+ C+R FY ++ C+ CP
Sbjct: 728 KCVSVCPLGYFG--DTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCP 785
Query: 124 PGTLAHQNTRECQERSPGQKK 144
G A ++ + C + P KK
Sbjct: 786 AGFYADESQKNCLKCHPSCKK 806
Score = 57.0 bits (136), Expect = 8e-09
Identities = 35/114 (30%), Positives = 51/114 (44%), Gaps = 23/114 (20%)
Query: 34 NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPG-YFGIRGQEVNRCKKCG 92
+C C+ E C+ C++ L G C+ DC PG YF E+ RC +C
Sbjct: 803 SCKKCV--DEPEKCTVCKEGFSL--------ARGSCIPDCEPGTYFD---SELIRCGECH 849
Query: 93 ATCESCFS--QDFCIRCKRQFYLYKGKCLPTCPPG-------TLAHQNTRECQE 137
TC +C ++ CI C + F+ + KC+P C G L H+ R C E
Sbjct: 850 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDE 903
Score = 56.6 bits (135), Expect = 1e-08
Identities = 31/98 (31%), Positives = 43/98 (43%), Gaps = 8/98 (8%)
Query: 46 GCSTCQQRLFL--FIRREGI---RQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFS 100
GC TC R R G ++ C+ CP G++ Q+ C KC +C+ C
Sbjct: 752 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQK--NCLKCHPSCKKCVD 809
Query: 101 Q-DFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQE 137
+ + C CK F L +G C+P C PGT C E
Sbjct: 810 EPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGE 847
>gi|20336180 paired basic amino acid cleaving system 4 isoform b
preproprotein [Homo sapiens]
Length = 956
Score = 58.2 bits (139), Expect = 4e-09
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 6/81 (7%)
Query: 68 KCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDF--CIRCKRQFYLYK--GKCLPTCP 123
KC+ CP GYFG RC++C CE+C S+ C+ C+R FY ++ C+ CP
Sbjct: 715 KCVSVCPLGYFG--DTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCP 772
Query: 124 PGTLAHQNTRECQERSPGQKK 144
G A ++ + C + P KK
Sbjct: 773 AGFYADESQKNCLKCHPSCKK 793
Score = 57.0 bits (136), Expect = 8e-09
Identities = 35/114 (30%), Positives = 51/114 (44%), Gaps = 23/114 (20%)
Query: 34 NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPG-YFGIRGQEVNRCKKCG 92
+C C+ E C+ C++ L G C+ DC PG YF E+ RC +C
Sbjct: 790 SCKKCV--DEPEKCTVCKEGFSL--------ARGSCIPDCEPGTYFD---SELIRCGECH 836
Query: 93 ATCESCFS--QDFCIRCKRQFYLYKGKCLPTCPPG-------TLAHQNTRECQE 137
TC +C ++ CI C + F+ + KC+P C G L H+ R C E
Sbjct: 837 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDE 890
Score = 56.6 bits (135), Expect = 1e-08
Identities = 31/98 (31%), Positives = 43/98 (43%), Gaps = 8/98 (8%)
Query: 46 GCSTCQQRLFL--FIRREGI---RQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFS 100
GC TC R R G ++ C+ CP G++ Q+ C KC +C+ C
Sbjct: 739 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQK--NCLKCHPSCKKCVD 796
Query: 101 Q-DFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQE 137
+ + C CK F L +G C+P C PGT C E
Sbjct: 797 EPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGE 834
>gi|239755070 PREDICTED: similar to proprotein convertase
subtilisin/kexin type 5 [Homo sapiens]
Length = 853
Score = 56.6 bits (135), Expect = 1e-08
Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 16/88 (18%)
Query: 34 NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
NC+ C ++NGC C++ FL G C+ C PG++G QE+ C+ C
Sbjct: 81 NCSSC----DQNGCYWCEEGFFLL--------GGSCVRKCGPGFYG--DQEMGECESCHR 126
Query: 94 TCESCF--SQDFCIRCKRQFYLYKGKCL 119
CE+C D C C+ L +G C+
Sbjct: 127 ACETCTGPGHDECSSCQEGLQLLRGMCV 154
Score = 53.1 bits (126), Expect = 1e-07
Identities = 38/118 (32%), Positives = 53/118 (44%), Gaps = 13/118 (11%)
Query: 38 CIICSEENGCSTCQQRLFLFIR--REGIRQYGK-CLHDCPPGYFGIRGQEVNRCKKCGAT 94
C C + C TC+ R R G Q GK CL C GY+ RC++C +
Sbjct: 510 CAHC--HSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYA--DNSTGRCERCNRS 565
Query: 95 CESCFSQ--DFCIRCKRQFYLY--KGKCLPTCPPGTLAHQNTRECQERSP--GQKKGR 146
C+ C C+ C R F+L KG+C +CP Q+T+ C+ P Q KG+
Sbjct: 566 CKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGK 623
Score = 51.2 bits (121), Expect = 4e-07
Identities = 34/118 (28%), Positives = 49/118 (41%), Gaps = 13/118 (11%)
Query: 44 ENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDF 103
E+ C TC L C+ DCP GY+ ++ NRC C ++C +C +
Sbjct: 476 EDQCQTCPMNSLLLNTT--------CVKDCPEGYYA--DEDSNRCAHCHSSCRTCEGRHS 525
Query: 104 --CIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQERSPGQKKGRKDRRPRKDRKLDR 159
C C+ ++ +CL C G A +T C ER KG + RP DR
Sbjct: 526 RQCHSCRPGWFQLGKECLLQCREGYYADNSTGRC-ERCNRSCKGCQGPRPTDCLSCDR 582
Score = 50.8 bits (120), Expect = 6e-07
Identities = 30/103 (29%), Positives = 40/103 (38%), Gaps = 15/103 (14%)
Query: 38 CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCES 97
C C E C C FL C CP G++ + + C C C
Sbjct: 323 CQDCIHEKTCKECMPEFFL--------HDDMCHQSCPRGFYA----DSHHCVPCHKDCLE 370
Query: 98 CFSQ--DFCIRC-KRQFYLYKGKCLPTCPPGTLAHQNTRECQE 137
C D C C + + LY G CL CP GT + T+EC++
Sbjct: 371 CSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKQTKECRD 413
Score = 50.4 bits (119), Expect = 7e-07
Identities = 30/108 (27%), Positives = 44/108 (40%), Gaps = 16/108 (14%)
Query: 38 CIICSEENGCSTCQQRLFLFIRREG--IRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC 95
C CS C TC+ EG + +G C +CP + + G CK C C
Sbjct: 270 CERCSSP--CRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVEGV----CKHCPEMC 323
Query: 96 ESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA--------HQNTREC 135
+ C + C C +F+L+ C +CP G A H++ EC
Sbjct: 324 QDCIHEKTCKECMPEFFLHDDMCHQSCPRGFYADSHHCVPCHKDCLEC 371
Score = 49.3 bits (116), Expect = 2e-06
Identities = 28/102 (27%), Positives = 43/102 (42%), Gaps = 13/102 (12%)
Query: 38 CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHD--CPPGYFGIRGQEVNRCKKCGATC 95
C+ CS C+TCQ+ L + R G C+ + C P + ++ CK C C
Sbjct: 418 CLTCSSSGTCTTCQKGLIMNPR-------GSCMANEKCSPSEYW--DEDAPGCKPCHVKC 468
Query: 96 ESCF--SQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTREC 135
C ++D C C L C+ CP G A +++ C
Sbjct: 469 FHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRC 510
Score = 47.8 bits (112), Expect = 5e-06
Identities = 23/68 (33%), Positives = 30/68 (44%), Gaps = 5/68 (7%)
Query: 69 CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA 128
C CP + E CK C + C SC Q+ C C+ F+L G C+ C PG
Sbjct: 60 CYKTCPEKTYS----EAVECKACDSNCSSC-DQNGCYWCEEGFFLLGGSCVRKCGPGFYG 114
Query: 129 HQNTRECQ 136
Q EC+
Sbjct: 115 DQEMGECE 122
Score = 45.4 bits (106), Expect = 2e-05
Identities = 27/103 (26%), Positives = 43/103 (41%), Gaps = 20/103 (19%)
Query: 41 CSEENG----CSTCQQRLFLFIRREGIRQYGKCLHDCPPGYF-GIRGQEVNRCKKCGATC 95
C NG C++C + +L + C+ CP G + +R C+ C C
Sbjct: 180 CKTCNGSATLCTSCPKGAYLLAQA--------CVSSCPQGTWPSVRS---GSCENCTEAC 228
Query: 96 ESCFSQDFCIRCKRQ----FYLYKGKCLPTCPPGTLAHQNTRE 134
C D C +C+ Q +L++G+C CP G+ A E
Sbjct: 229 AICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICE 271
Score = 38.9 bits (89), Expect = 0.002
Identities = 23/104 (22%), Positives = 44/104 (42%), Gaps = 14/104 (13%)
Query: 38 CIICS--EENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC 95
C+ CS + + C C + ++ G CL +CP G + ++ C+ C +C
Sbjct: 368 CLECSGPKADDCELCLESSWVLYD-------GLCLEECPAGTY--YEKQTKECRDCHKSC 418
Query: 96 ESCFSQDFCIRCKRQFYLY-KGKCLPT--CPPGTLAHQNTRECQ 136
+C S C C++ + +G C+ C P ++ C+
Sbjct: 419 LTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCK 462
Score = 30.8 bits (68), Expect = 0.60
Identities = 22/79 (27%), Positives = 30/79 (37%), Gaps = 11/79 (13%)
Query: 67 GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDF--CIRCKRQFYLY--KGKCLPTC 122
G C DC G + + E C+KC +C C C C L+ + CL C
Sbjct: 640 GICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDESHCLHCC 699
Query: 123 ----PPGTLAHQNTRECQE 137
PP Q +CQ+
Sbjct: 700 NTSDPPSA---QECCDCQD 715
>gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo
sapiens]
Length = 853
Score = 55.5 bits (132), Expect = 2e-08
Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 16/88 (18%)
Query: 34 NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
NC C ++NGC C++ FL G C+ C PG++G QE+ C+ C
Sbjct: 81 NCGSC----DQNGCYWCEEGFFLL--------GGSCVRKCGPGFYG--DQEMGECESCHR 126
Query: 94 TCESCF--SQDFCIRCKRQFYLYKGKCL 119
CE+C D C C+ L +G C+
Sbjct: 127 ACETCTGPGHDECSSCQEGLQLLRGMCV 154
Score = 53.1 bits (126), Expect = 1e-07
Identities = 38/118 (32%), Positives = 53/118 (44%), Gaps = 13/118 (11%)
Query: 38 CIICSEENGCSTCQQRLFLFIR--REGIRQYGK-CLHDCPPGYFGIRGQEVNRCKKCGAT 94
C C + C TC+ R R G Q GK CL C GY+ RC++C +
Sbjct: 510 CAHC--HSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYA--DNSTGRCERCNRS 565
Query: 95 CESCFSQ--DFCIRCKRQFYLY--KGKCLPTCPPGTLAHQNTRECQERSP--GQKKGR 146
C+ C C+ C R F+L KG+C +CP Q+T+ C+ P Q KG+
Sbjct: 566 CKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGK 623
Score = 51.6 bits (122), Expect = 3e-07
Identities = 29/100 (29%), Positives = 44/100 (44%), Gaps = 10/100 (10%)
Query: 38 CIICSEENGCSTCQQRLFLFIRREG--IRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC 95
C CS C TC+ EG + +G C +CP + ++G CK C C
Sbjct: 270 CERCSSP--CRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVKGV----CKHCPEMC 323
Query: 96 ESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTREC 135
+ C + C C +F+L+ C +CP G A ++R C
Sbjct: 324 QDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYA--DSRHC 361
Score = 51.2 bits (121), Expect = 4e-07
Identities = 34/118 (28%), Positives = 49/118 (41%), Gaps = 13/118 (11%)
Query: 44 ENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDF 103
E+ C TC L C+ DCP GY+ ++ NRC C ++C +C +
Sbjct: 476 EDQCQTCPMNSLLLNTT--------CVKDCPEGYYA--DEDSNRCAHCHSSCRTCEGRHS 525
Query: 104 --CIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQERSPGQKKGRKDRRPRKDRKLDR 159
C C+ ++ +CL C G A +T C ER KG + RP DR
Sbjct: 526 RQCHSCRPGWFQLGKECLLQCREGYYADNSTGRC-ERCNRSCKGCQGPRPTDCLSCDR 582
Score = 50.1 bits (118), Expect = 1e-06
Identities = 30/103 (29%), Positives = 39/103 (37%), Gaps = 15/103 (14%)
Query: 38 CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCES 97
C C E C C FL C CP G++ + C C C
Sbjct: 323 CQDCIHEKTCKECTPEFFL--------HDDMCHQSCPRGFYA----DSRHCVPCHKDCLE 370
Query: 98 CFSQ--DFCIRC-KRQFYLYKGKCLPTCPPGTLAHQNTRECQE 137
C D C C + + LY G CL CP GT + T+EC++
Sbjct: 371 CSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKECRD 413
Score = 49.3 bits (116), Expect = 2e-06
Identities = 28/102 (27%), Positives = 43/102 (42%), Gaps = 13/102 (12%)
Query: 38 CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHD--CPPGYFGIRGQEVNRCKKCGATC 95
C+ CS C+TCQ+ L + R G C+ + C P + ++ CK C C
Sbjct: 418 CLTCSSSGTCTTCQKGLIMNPR-------GSCMANEKCSPSEYW--DEDAPGCKPCHVKC 468
Query: 96 ESCF--SQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTREC 135
C ++D C C L C+ CP G A +++ C
Sbjct: 469 FHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRC 510
Score = 47.0 bits (110), Expect = 8e-06
Identities = 23/68 (33%), Positives = 30/68 (44%), Gaps = 5/68 (7%)
Query: 69 CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA 128
C CP + E CK C + C SC Q+ C C+ F+L G C+ C PG
Sbjct: 60 CYKTCPEKTYS----EAVECKACDSNCGSC-DQNGCYWCEEGFFLLGGSCVRKCGPGFYG 114
Query: 129 HQNTRECQ 136
Q EC+
Sbjct: 115 DQEMGECE 122
Score = 45.4 bits (106), Expect = 2e-05
Identities = 27/103 (26%), Positives = 43/103 (41%), Gaps = 20/103 (19%)
Query: 41 CSEENG----CSTCQQRLFLFIRREGIRQYGKCLHDCPPGYF-GIRGQEVNRCKKCGATC 95
C NG C++C + +L + C+ CP G + +R C+ C C
Sbjct: 180 CKTCNGSATLCTSCPKGAYLLAQA--------CVSSCPQGTWPSVRS---GSCENCTEAC 228
Query: 96 ESCFSQDFCIRCKRQ----FYLYKGKCLPTCPPGTLAHQNTRE 134
C D C +C+ Q +L++G+C CP G+ A E
Sbjct: 229 AICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICE 271
Score = 40.0 bits (92), Expect = 0.001
Identities = 24/104 (23%), Positives = 44/104 (42%), Gaps = 14/104 (13%)
Query: 38 CIICS--EENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC 95
C+ CS + + C C + ++ G CL +CP G + +E C+ C +C
Sbjct: 368 CLECSGPKADDCELCLESSWVLYD-------GLCLEECPAGTY--YEKETKECRDCHKSC 418
Query: 96 ESCFSQDFCIRCKRQFYLY-KGKCLPT--CPPGTLAHQNTRECQ 136
+C S C C++ + +G C+ C P ++ C+
Sbjct: 419 LTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCK 462
Score = 30.0 bits (66), Expect = 1.0
Identities = 22/79 (27%), Positives = 29/79 (36%), Gaps = 11/79 (13%)
Query: 67 GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDF--CIRCKRQFYLY--KGKCLPTC 122
G C DC G + + E C+KC +C C C C L+ CL C
Sbjct: 640 GICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCC 699
Query: 123 ----PPGTLAHQNTRECQE 137
PP Q +CQ+
Sbjct: 700 NTSDPPSA---QECCDCQD 715
>gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo
sapiens]
Length = 853
Score = 55.5 bits (132), Expect = 2e-08
Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 16/88 (18%)
Query: 34 NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
NC C ++NGC C++ FL G C+ C PG++G QE+ C+ C
Sbjct: 81 NCGSC----DQNGCYWCEEGFFLL--------GGSCVRKCGPGFYG--DQEMGECESCHR 126
Query: 94 TCESCF--SQDFCIRCKRQFYLYKGKCL 119
CE+C D C C+ L +G C+
Sbjct: 127 ACETCTGPGHDECSSCQEGLQLLRGMCV 154
Score = 53.1 bits (126), Expect = 1e-07
Identities = 38/118 (32%), Positives = 53/118 (44%), Gaps = 13/118 (11%)
Query: 38 CIICSEENGCSTCQQRLFLFIR--REGIRQYGK-CLHDCPPGYFGIRGQEVNRCKKCGAT 94
C C + C TC+ R R G Q GK CL C GY+ RC++C +
Sbjct: 510 CAHC--HSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYA--DNSTGRCERCNRS 565
Query: 95 CESCFSQ--DFCIRCKRQFYLY--KGKCLPTCPPGTLAHQNTRECQERSP--GQKKGR 146
C+ C C+ C R F+L KG+C +CP Q+T+ C+ P Q KG+
Sbjct: 566 CKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGK 623
Score = 51.6 bits (122), Expect = 3e-07
Identities = 29/100 (29%), Positives = 44/100 (44%), Gaps = 10/100 (10%)
Query: 38 CIICSEENGCSTCQQRLFLFIRREG--IRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC 95
C CS C TC+ EG + +G C +CP + ++G CK C C
Sbjct: 270 CERCSSP--CRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVKGV----CKHCPEMC 323
Query: 96 ESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTREC 135
+ C + C C +F+L+ C +CP G A ++R C
Sbjct: 324 QDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYA--DSRHC 361
Score = 51.2 bits (121), Expect = 4e-07
Identities = 34/118 (28%), Positives = 49/118 (41%), Gaps = 13/118 (11%)
Query: 44 ENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDF 103
E+ C TC L C+ DCP GY+ ++ NRC C ++C +C +
Sbjct: 476 EDQCQTCPMNSLLLNTT--------CVKDCPEGYYA--DEDSNRCAHCHSSCRTCEGRHS 525
Query: 104 --CIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQERSPGQKKGRKDRRPRKDRKLDR 159
C C+ ++ +CL C G A +T C ER KG + RP DR
Sbjct: 526 RQCHSCRPGWFQLGKECLLQCREGYYADNSTGRC-ERCNRSCKGCQGPRPTDCLSCDR 582
Score = 50.1 bits (118), Expect = 1e-06
Identities = 30/103 (29%), Positives = 39/103 (37%), Gaps = 15/103 (14%)
Query: 38 CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCES 97
C C E C C FL C CP G++ + C C C
Sbjct: 323 CQDCIHEKTCKECTPEFFL--------HDDMCHQSCPRGFYA----DSRHCVPCHKDCLE 370
Query: 98 CFSQ--DFCIRC-KRQFYLYKGKCLPTCPPGTLAHQNTRECQE 137
C D C C + + LY G CL CP GT + T+EC++
Sbjct: 371 CSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKECRD 413
Score = 49.3 bits (116), Expect = 2e-06
Identities = 28/102 (27%), Positives = 43/102 (42%), Gaps = 13/102 (12%)
Query: 38 CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHD--CPPGYFGIRGQEVNRCKKCGATC 95
C+ CS C+TCQ+ L + R G C+ + C P + ++ CK C C
Sbjct: 418 CLTCSSSGTCTTCQKGLIMNPR-------GSCMANEKCSPSEYW--DEDAPGCKPCHVKC 468
Query: 96 ESCF--SQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTREC 135
C ++D C C L C+ CP G A +++ C
Sbjct: 469 FHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRC 510
Score = 46.2 bits (108), Expect = 1e-05
Identities = 23/68 (33%), Positives = 30/68 (44%), Gaps = 5/68 (7%)
Query: 69 CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA 128
C CP + E CK C + C SC Q+ C C+ F+L G C+ C PG
Sbjct: 60 CYKTCPEKTYS----EEVECKACDSNCGSC-DQNGCYWCEEGFFLLGGSCVRKCGPGFYG 114
Query: 129 HQNTRECQ 136
Q EC+
Sbjct: 115 DQEMGECE 122
Score = 45.4 bits (106), Expect = 2e-05
Identities = 27/103 (26%), Positives = 43/103 (41%), Gaps = 20/103 (19%)
Query: 41 CSEENG----CSTCQQRLFLFIRREGIRQYGKCLHDCPPGYF-GIRGQEVNRCKKCGATC 95
C NG C++C + +L + C+ CP G + +R C+ C C
Sbjct: 180 CKTCNGSATLCTSCPKGAYLLAQA--------CVSSCPQGTWPSVRS---GSCENCTEAC 228
Query: 96 ESCFSQDFCIRCKRQ----FYLYKGKCLPTCPPGTLAHQNTRE 134
C D C +C+ Q +L++G+C CP G+ A E
Sbjct: 229 AICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICE 271
Score = 40.0 bits (92), Expect = 0.001
Identities = 24/104 (23%), Positives = 44/104 (42%), Gaps = 14/104 (13%)
Query: 38 CIICS--EENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC 95
C+ CS + + C C + ++ G CL +CP G + +E C+ C +C
Sbjct: 368 CLECSGPKADDCELCLESSWVLYD-------GLCLEECPAGTY--YEKETKECRDCHKSC 418
Query: 96 ESCFSQDFCIRCKRQFYLY-KGKCLPT--CPPGTLAHQNTRECQ 136
+C S C C++ + +G C+ C P ++ C+
Sbjct: 419 LTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCK 462
Score = 30.0 bits (66), Expect = 1.0
Identities = 22/79 (27%), Positives = 29/79 (36%), Gaps = 11/79 (13%)
Query: 67 GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDF--CIRCKRQFYLY--KGKCLPTC 122
G C DC G + + E C+KC +C C C C L+ CL C
Sbjct: 640 GICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCC 699
Query: 123 ----PPGTLAHQNTRECQE 137
PP Q +CQ+
Sbjct: 700 NTSDPPSA---QECCDCQD 715
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 54.3 bits (129), Expect = 5e-08
Identities = 39/146 (26%), Positives = 57/146 (39%), Gaps = 28/146 (19%)
Query: 33 GNCTGCIICSEENG-----CSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNR 87
G C+ C + G C TC ++ L GKC+ +CP GY+ R
Sbjct: 556 GTCSACDQSCDSCGPSSPRCLTCTEKTVL--------HDGKCMSECPGGYY---ADATGR 604
Query: 88 CKKCGATCESCF--SQDFCIRCKRQFYLYKGKCLPTCPPG--------TLAHQNTRECQE 137
CK C +C SC + C C L +G CLP C G H + C
Sbjct: 605 CKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMG 664
Query: 138 RSPGQKKGRKDRRPRKDRKLDRRLDV 163
+P G K +P + ++++ DV
Sbjct: 665 PAPSHCTGCK--KPEEGLQVEQLSDV 688
Score = 53.9 bits (128), Expect = 7e-08
Identities = 26/98 (26%), Positives = 40/98 (40%), Gaps = 10/98 (10%)
Query: 38 CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCES 97
C+ C + C+ C+ L +C+ +C GYF + ++C C C
Sbjct: 1008 CLQCQGPHECTRCKGPFLLL--------EAQCVQECGKGYFADHAK--HKCTACPQGCLQ 1057
Query: 98 CFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTREC 135
C +D C C F+L G C+ C PG H + C
Sbjct: 1058 CSHRDRCHLCDHGFFLKSGLCVYNCVPGFSVHTSNETC 1095
Score = 48.9 bits (115), Expect = 2e-06
Identities = 29/99 (29%), Positives = 43/99 (43%), Gaps = 14/99 (14%)
Query: 38 CIICSEE-NGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCE 96
C+ CS+ + C CQ L Q G C+H C G++ Q + C C C
Sbjct: 425 CLTCSQSPDHCDLCQDPTKLL-------QNGWCVHSCGLGFY----QAGSLCLACQPQCS 473
Query: 97 SCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTREC 135
+C S C C+ + G+C+PTC G +Q+ C
Sbjct: 474 TCTSGLECSSCQPPLLMRHGQCVPTCGDG--FYQDRHSC 510
Score = 48.1 bits (113), Expect = 4e-06
Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 13/101 (12%)
Query: 34 NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
+C GC +E++ C C+ L + + G C C G++ +G C C
Sbjct: 516 SCAGCWGPTEKH-CLACRDPLHVL-------RDGGCESSCGKGFYNRQGT----CSACDQ 563
Query: 94 TCESCF-SQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTR 133
+C+SC S C+ C + L+ GKC+ CP G A R
Sbjct: 564 SCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGR 604
Score = 47.0 bits (110), Expect = 8e-06
Identities = 31/102 (30%), Positives = 40/102 (39%), Gaps = 16/102 (15%)
Query: 35 CTGCIICSEENG--CSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCG 92
C C G C CQ +L + C+ DCP GY+ RG CKKC
Sbjct: 813 CQHCAADLHNTGSICLRCQNAHYLLLGDH-------CVPDCPSGYYAERG----ACKKCH 861
Query: 93 ATCESCFSQD--FCIRCKRQFYL-YKGKCLPTCPPGTLAHQN 131
++C +C + C C L + G C TC PG N
Sbjct: 862 SSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHYLDDN 903
Score = 43.5 bits (101), Expect = 9e-05
Identities = 21/58 (36%), Positives = 25/58 (43%), Gaps = 6/58 (10%)
Query: 67 GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFS--QDFCIRCKRQFYLYKGKCLPTC 122
G+CL CP GYF G C +C TC C + CI C L G C +C
Sbjct: 741 GQCLSQCPDGYFHQEGS----CTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSC 794
Score = 41.2 bits (95), Expect = 4e-04
Identities = 22/90 (24%), Positives = 41/90 (45%), Gaps = 12/90 (13%)
Query: 36 TGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHD-CPPGYFGIRGQEVNRCKKCGAT 94
T C C + C++C+ + + +G+C ++ C P Y+ N CK+C +
Sbjct: 911 THCGSCDSQASCTSCRDPNKVLL-------FGECQYESCAPQYY--LDFSTNTCKECDWS 961
Query: 95 CESCFS--QDFCIRCKRQFYLYKGKCLPTC 122
C +C + C++C + L G C+ C
Sbjct: 962 CSACSGPLKTDCLQCMDGYVLQDGACVEQC 991
Score = 41.2 bits (95), Expect = 4e-04
Identities = 21/73 (28%), Positives = 31/73 (42%), Gaps = 5/73 (6%)
Query: 63 IRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTC 122
+ Q G C+ C ++ Q+ CK C + C C C RCK F L + +C+ C
Sbjct: 981 VLQDGACVEQCLSSFY----QDSGLCK-CDSYCLQCQGPHECTRCKGPFLLLEAQCVQEC 1035
Query: 123 PPGTLAHQNTREC 135
G A +C
Sbjct: 1036 GKGYFADHAKHKC 1048
Score = 34.7 bits (78), Expect = 0.042
Identities = 22/79 (27%), Positives = 30/79 (37%), Gaps = 13/79 (16%)
Query: 67 GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCF--SQDFCIRCKRQFYLYKGKCLPTCPP 124
G+CL C ++ + C+ C +C C S C C L G+CL CP
Sbjct: 693 GECLAQCRAHFYL---ESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPD 749
Query: 125 G--------TLAHQNTREC 135
G T H R+C
Sbjct: 750 GYFHQEGSCTECHPTCRQC 768
Score = 31.6 bits (70), Expect = 0.35
Identities = 13/41 (31%), Positives = 20/41 (48%), Gaps = 8/41 (19%)
Query: 37 GCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGY 77
GC+ CS + C C FL + G C+++C PG+
Sbjct: 1054 GCLQCSHRDRCHLCDHGFFL--------KSGLCVYNCVPGF 1086
>gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
Length = 913
Score = 53.5 bits (127), Expect = 9e-08
Identities = 26/79 (32%), Positives = 39/79 (49%), Gaps = 7/79 (8%)
Query: 69 CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQ--DFCIRCKRQFYLYK--GKCLPTCPP 124
C+ CPPG++ + RC+KC CESCF D C+ CK ++L + C+ CP
Sbjct: 670 CVSSCPPGHYHA---DKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPD 726
Query: 125 GTLAHQNTRECQERSPGQK 143
G+ C++ S K
Sbjct: 727 GSYQDTKKNLCRKCSENCK 745
Score = 46.2 bits (108), Expect = 1e-05
Identities = 27/103 (26%), Positives = 44/103 (42%), Gaps = 11/103 (10%)
Query: 34 NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
NC C S + C +C+ FL + C+ CP G + + + N C+KC
Sbjct: 692 NCESCF-GSHGDQCMSCKYGYFLN------EETNSCVTHCPDGSY--QDTKKNLCRKCSE 742
Query: 94 TCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQ 136
C++C C C+ L +C +C G + N ++CQ
Sbjct: 743 NCKTCTEFHNCTECRDGLSLQGSRCSVSCEDG--RYFNGQDCQ 783
Score = 45.1 bits (105), Expect = 3e-05
Identities = 24/85 (28%), Positives = 38/85 (44%), Gaps = 10/85 (11%)
Query: 38 CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCES 97
C C+E + C+ C+ L L Q +C C G + GQ+ C + ATC
Sbjct: 744 CKTCTEFHNCTECRDGLSL--------QGSRCSVSCEDGRY-FNGQDCQPCHRFCATCAG 794
Query: 98 CFSQDFCIRCKRQFYLYKGKCLPTC 122
D CI C +++ G+C+ +C
Sbjct: 795 A-GADGCINCTEGYFMEDGRCVQSC 818
Score = 37.4 bits (85), Expect = 0.006
Identities = 23/87 (26%), Positives = 34/87 (39%), Gaps = 14/87 (16%)
Query: 38 CIICSEE--NGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQE--VNRCKKCGA 93
C C+ +GC C + F+ + G+C+ C Y+ E CKKC
Sbjct: 789 CATCAGAGADGCINCTEGYFM--------EDGRCVQSCSISYYFDHSSENGYKSCKKCDI 840
Query: 94 TCESCFSQDF--CIRCKRQFYLYKGKC 118
+C +C F C C + L G C
Sbjct: 841 SCLTCNGPGFKNCTSCPSGYLLDLGMC 867
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 38.9 bits (89), Expect = 0.002
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 5/73 (6%)
Query: 68 KCLHDCPPGYFGIRGQEVNRC--KKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPG 125
+C CP E N C +C +C + + C+ C+ Y Y G C+P CPP
Sbjct: 210 RCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRH--YYYAGVCVPACPPN 267
Query: 126 TLAHQNTRECQER 138
T + R C +R
Sbjct: 268 TYRFEGWR-CVDR 279
Score = 30.4 bits (67), Expect = 0.79
Identities = 21/99 (21%), Positives = 31/99 (31%), Gaps = 31/99 (31%)
Query: 35 CTG-CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
C G C + C C+ + G C+ CPP + G
Sbjct: 235 CLGSCSAPDNDTACVACRHYYYA----------GVCVPACPPNTYRFEGWR--------- 275
Query: 94 TCESCFSQDFCIRC-------KRQFYLYKGKCLPTCPPG 125
C +DFC F ++ G+C+ CP G
Sbjct: 276 ----CVDRDFCANILSAESSDSEGFVIHDGECMQECPSG 310
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 38.9 bits (89), Expect = 0.002
Identities = 20/67 (29%), Positives = 29/67 (43%), Gaps = 6/67 (8%)
Query: 69 CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA 128
C H CP G+FG+ + C GA C++ C +R +C TCP T
Sbjct: 943 CEHACPAGFFGLDCRSACNC-TAGAACDAVNGSCLCPAGRR-----GPRCAETCPAHTYG 996
Query: 129 HQNTREC 135
H ++ C
Sbjct: 997 HNCSQAC 1003
Score = 33.9 bits (76), Expect = 0.071
Identities = 25/78 (32%), Positives = 33/78 (42%), Gaps = 20/78 (25%)
Query: 66 YGK-CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPP 124
YG+ C H CPPG+ G Q + C+ GA C+ G+CL CP
Sbjct: 1370 YGQACEHPCPPGFHGAGCQGLCWCQH-GAPCDP----------------ISGRCL--CPA 1410
Query: 125 GTLAHQNTRECQERSPGQ 142
G H R C+ S G+
Sbjct: 1411 GFHGHFCERGCEPGSFGE 1428
Score = 33.5 bits (75), Expect = 0.093
Identities = 33/109 (30%), Positives = 41/109 (37%), Gaps = 18/109 (16%)
Query: 32 GGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKC 91
G NC+ CS +NG TC G+ C CP GY+G K C
Sbjct: 561 GKNCS--FSCSCQNG-GTCDSVTGACRCPPGVSGTN-CEDGCPKGYYG---------KHC 607
Query: 92 GATCESCFSQDFCIR----CKRQFYLYKGKCLPTCPPGTLAHQNTRECQ 136
C +C ++ C R C LY C TCPP + ECQ
Sbjct: 608 RKKC-NCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQ 655
Score = 32.0 bits (71), Expect = 0.27
Identities = 42/155 (27%), Positives = 53/155 (34%), Gaps = 44/155 (28%)
Query: 32 GGNC---TGCIICSE-------ENGCST------CQQRLFLFIRREGIRQYGKCLHD--- 72
GG C TG C E+GC C+++ R R YG CL D
Sbjct: 573 GGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGL 632
Query: 73 --------CPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQF------------Y 112
CPP FG E +C + +SC +D CK F Y
Sbjct: 633 YGRFCHLTCPPWAFGPGCSEECQCVQ--PHTQSCDKRDGSCSCKAGFRGERCQAECELGY 690
Query: 113 LYKGKCLP--TCPPGTLAHQNTRECQERSPGQKKG 145
G C TCP G + EC +R P +G
Sbjct: 691 FGPG-CWQACTCPVGVACDSVSGECGKRCPAGFQG 724
Score = 31.6 bits (70), Expect = 0.35
Identities = 28/108 (25%), Positives = 41/108 (37%), Gaps = 25/108 (23%)
Query: 35 CTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHD------CPPGYFGIRGQ-EVNR 87
C G + +E GC + + L G+C+ CPPG+ G R Q +V+
Sbjct: 111 CRGWMQQPDEEGCLSAECSASLCFHG------GRCVPGSAQPCHCPPGFQGPRCQYDVDE 164
Query: 88 CKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTREC 135
C+ C+ RC G L C PG H ++R C
Sbjct: 165 CRTHNGGCQH--------RCVNT----PGSYLCECKPGFRLHTDSRTC 200
Score = 30.4 bits (67), Expect = 0.79
Identities = 30/120 (25%), Positives = 39/120 (32%), Gaps = 37/120 (30%)
Query: 32 GGNC---TGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHD-----------CPPGY 77
GG C +G C E C++ R G R G CL+ CP G+
Sbjct: 1051 GGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGW 1110
Query: 78 FGIRGQEVNRCKKCGATC-ESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQ 136
G KC + C F + RC +CPPG H T C+
Sbjct: 1111 TG---------DKCQSPCLRGWFGEACAQRC-------------SCPPGAACHHVTGACR 1148
Score = 29.6 bits (65), Expect = 1.3
Identities = 20/67 (29%), Positives = 25/67 (37%), Gaps = 6/67 (8%)
Query: 69 CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA 128
C CPPG +G +++ C G SC + RC F C TCP G
Sbjct: 1202 CQQRCPPGRYGPGCEQLCGCLNGG----SCDAATGACRCPTGF--LGTDCNLTCPQGRFG 1255
Query: 129 HQNTREC 135
T C
Sbjct: 1256 PNCTHVC 1262
Score = 28.9 bits (63), Expect = 2.3
Identities = 29/111 (26%), Positives = 34/111 (30%), Gaps = 24/111 (21%)
Query: 32 GGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKC 91
G NCT C + C G CL CPPG G+R + +
Sbjct: 1255 GPNCTHVCGCGQGAACDPVT---------------GTCL--CPPGRAGVRCERGCPQNRF 1297
Query: 92 GATCE---SCFSQDFCI----RCKRQFYLYKGKCLPTCPPGTLAHQNTREC 135
G CE SC + C C C CPPG EC
Sbjct: 1298 GVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLEC 1348
Score = 27.3 bits (59), Expect = 6.7
Identities = 22/72 (30%), Positives = 29/72 (40%), Gaps = 14/72 (19%)
Query: 67 GKCLHDCPPGYFGIRGQEVNRCKKCGATCE---SCFSQDFCIRCKRQFYLYKGKCLPTCP 123
G CL C PG+ G R Q+V G +C+ SC + C + G C +C
Sbjct: 800 GACL--CLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHC-------HPATGHC--SCA 848
Query: 124 PGTLAHQNTREC 135
PG R C
Sbjct: 849 PGWTGFSCQRAC 860
>gi|14790170 tumor necrosis factor receptor superfamily, member 6b
[Homo sapiens]
Length = 300
Score = 38.5 bits (88), Expect = 0.003
Identities = 28/101 (27%), Positives = 42/101 (41%), Gaps = 17/101 (16%)
Query: 57 FIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC-------ESCF-SQDFCIRCK 108
F++R R CPP ++ + RC+ C C +C + + RC+
Sbjct: 57 FVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCR 116
Query: 109 RQFYLYKGKCL--PTCPPGT------LAHQNTRECQERSPG 141
F+ + G CL +CPPG QNT +CQ PG
Sbjct: 117 TGFFAHAGFCLEHASCPPGAGVIAPGTPSQNT-QCQPCPPG 156
>gi|145309326 laminin, gamma 1 precursor [Homo sapiens]
Length = 1609
Score = 38.5 bits (88), Expect = 0.003
Identities = 28/98 (28%), Positives = 41/98 (41%), Gaps = 11/98 (11%)
Query: 29 TGLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRC 88
TG GG+CT C ++ C C++ F R G + H P G + RC
Sbjct: 361 TGHGGHCTNCQDNTDGAHCERCRENFF----RLGNNEACSSCHCSPVGSLSTQCDSYGRC 416
Query: 89 KKCGATCESCFSQDFCIRCKRQFY-LYKGKCLP-TCPP 124
+C+ D C RC+ F+ L + C P +C P
Sbjct: 417 -----SCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDP 449
>gi|4507585 tumor necrosis factor receptor superfamily, member 6b
[Homo sapiens]
Length = 300
Score = 38.5 bits (88), Expect = 0.003
Identities = 28/101 (27%), Positives = 42/101 (41%), Gaps = 17/101 (16%)
Query: 57 FIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC-------ESCF-SQDFCIRCK 108
F++R R CPP ++ + RC+ C C +C + + RC+
Sbjct: 57 FVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCR 116
Query: 109 RQFYLYKGKCL--PTCPPGT------LAHQNTRECQERSPG 141
F+ + G CL +CPPG QNT +CQ PG
Sbjct: 117 TGFFAHAGFCLEHASCPPGAGVIAPGTPSQNT-QCQPCPPG 156
>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
Length = 1044
Score = 38.5 bits (88), Expect = 0.003
Identities = 31/105 (29%), Positives = 38/105 (36%), Gaps = 12/105 (11%)
Query: 32 GGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKC 91
G NC+ CS +GC GIR C CPPG +G C+
Sbjct: 529 GLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIR----CDSTCPPGRWGPNCSVSCSCENG 584
Query: 92 GATCESCFSQDFCIRCKRQFYLYKGK-CLPTCPPGTLAHQNTREC 135
G SC +D C F +G C CPPG H + C
Sbjct: 585 G----SCSPEDGSCECAPGF---RGPLCQRICPPGFYGHGCAQPC 622
Score = 34.7 bits (78), Expect = 0.042
Identities = 25/83 (30%), Positives = 34/83 (40%), Gaps = 9/83 (10%)
Query: 67 GKCLHDCPPGYFGIRGQEVNRCKKCGATCE---SCFSQDFCIRCKRQFYLYKG----KCL 119
G+CL C PGY G+ +E+ GA CE C + C + G C
Sbjct: 202 GECL--CAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCA 259
Query: 120 PTCPPGTLAHQNTRECQERSPGQ 142
CPPGT +++C GQ
Sbjct: 260 QPCPPGTFGQNCSQDCPCHHGGQ 282
>gi|119395738 insulin receptor isoform Short precursor [Homo
sapiens]
Length = 1370
Score = 38.1 bits (87), Expect = 0.004
Identities = 21/76 (27%), Positives = 32/76 (42%), Gaps = 16/76 (21%)
Query: 67 GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKR-------QFYLYKGKCL 119
G+C+ CPP Y+ + RC F QD +CK Q+ ++ KC+
Sbjct: 262 GRCVETCPPPYYHFQDW---RCVNFS------FCQDLHHKCKNSRRQGCHQYVIHNNKCI 312
Query: 120 PTCPPGTLAHQNTREC 135
P CP G + + C
Sbjct: 313 PECPSGYTMNSSNLLC 328
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 38.1 bits (87), Expect = 0.004
Identities = 21/76 (27%), Positives = 32/76 (42%), Gaps = 16/76 (21%)
Query: 67 GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKR-------QFYLYKGKCL 119
G+C+ CPP Y+ + RC F QD +CK Q+ ++ KC+
Sbjct: 262 GRCVETCPPPYYHFQDW---RCVNFS------FCQDLHHKCKNSRRQGCHQYVIHNNKCI 312
Query: 120 PTCPPGTLAHQNTREC 135
P CP G + + C
Sbjct: 313 PECPSGYTMNSSNLLC 328
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 37.4 bits (85), Expect = 0.006
Identities = 28/84 (33%), Positives = 40/84 (47%), Gaps = 8/84 (9%)
Query: 73 CPPGYF--GIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQ 130
CPPGY GI+ +V+ CK+ ++CF+ + RC+ Y CLP CPP Q
Sbjct: 575 CPPGYSGNGIQCTDVDECKE---VPDACFNHNGEHRCENTDPGY--NCLP-CPPRFTGSQ 628
Query: 131 NTRECQERSPGQKKGRKDRRPRKD 154
+ E + K+ K R P D
Sbjct: 629 PFGQGVEHATANKQVCKPRNPCTD 652
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 36.6 bits (83), Expect = 0.011
Identities = 27/101 (26%), Positives = 37/101 (36%), Gaps = 17/101 (16%)
Query: 37 GCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCE 96
GC + C C+ F G CL CPPG + E RC T E
Sbjct: 236 GCSQPEDPRACVACRHLYF----------QGACLWACPPGTYQY---ESWRC----VTAE 278
Query: 97 SCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQE 137
C S F +++G CL CP G + ++ C +
Sbjct: 279 RCASLHSVPGRASTFGIHQGSCLAQCPSGFTRNSSSIFCHK 319
Score = 31.6 bits (70), Expect = 0.35
Identities = 13/44 (29%), Positives = 22/44 (50%), Gaps = 2/44 (4%)
Query: 90 KCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTR 133
+C C C+ C+ ++ +G CL CPPGT +++ R
Sbjct: 232 ECLGGCSQPEDPRACVACRHLYF--QGACLWACPPGTYQYESWR 273
>gi|111125011 WNT inhibitory factor 1 precursor [Homo sapiens]
Length = 379
Score = 35.4 bits (80), Expect = 0.024
Identities = 22/64 (34%), Positives = 29/64 (45%), Gaps = 19/64 (29%)
Query: 67 GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGT 126
G C+ CPPG++G+ + N C T CF+ C Y GKC+ CPPG
Sbjct: 228 GFCI--CPPGFYGVNCDKAN----CSTT---CFNGGTC--------FYPGKCI--CPPGL 268
Query: 127 LAHQ 130
Q
Sbjct: 269 EGEQ 272
>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
sapiens]
Length = 1037
Score = 35.4 bits (80), Expect = 0.024
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 17/80 (21%)
Query: 69 CLHDCPPGYFGIRGQEVNRCKKCGATCE-----SCFSQDFCIRCKRQFYLYKGKCLPTCP 123
C CPPG++G + C TC+ +C QD C + + CL CP
Sbjct: 648 CSQPCPPGHWG---------ENCAQTCQCHHGGTCHPQDGSCICPLGWTGH--HCLEGCP 696
Query: 124 PGTLAHQNTRECQERSPGQK 143
GT ++ CQ PG+K
Sbjct: 697 LGTFGANCSQPCQ-CGPGEK 715
Score = 32.0 bits (71), Expect = 0.27
Identities = 21/73 (28%), Positives = 26/73 (35%), Gaps = 16/73 (21%)
Query: 69 CLHDCPPGYFGIRGQEVNRCKKCGATCE-----SCFSQDFCIRCKRQFYLYKGKCLPTCP 123
C CPP +G+ C A C +C D CK + +G C CP
Sbjct: 434 CASLCPPDTYGVN---------CSARCSCENAIACSPIDGECVCKEGWQ--RGNCSVPCP 482
Query: 124 PGTLAHQNTRECQ 136
PGT CQ
Sbjct: 483 PGTWGFSCNASCQ 495
Score = 31.6 bits (70), Expect = 0.35
Identities = 21/71 (29%), Positives = 28/71 (39%), Gaps = 12/71 (16%)
Query: 34 NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
+C C ++G +C L Q CL C PGY+G Q RC+ GA
Sbjct: 149 SCGNNSSCDPKSGVCSCPSGL----------QPPNCLQPCTPGYYGPACQ--FRCQCHGA 196
Query: 94 TCESCFSQDFC 104
C+ FC
Sbjct: 197 PCDPQTGACFC 207
Score = 30.0 bits (66), Expect = 1.0
Identities = 25/92 (27%), Positives = 33/92 (35%), Gaps = 29/92 (31%)
Query: 34 NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
+C I CS +G C++ Q G C CPPG +G C A
Sbjct: 452 SCENAIACSPIDGECVCKEGW----------QRGNCSVPCPPGTWGF---------SCNA 492
Query: 94 TCESCFSQDFCIRCKRQFYLYKGKCLPTCPPG 125
+C+ C + C G C TC PG
Sbjct: 493 SCQ-CAHEAVCSP-------QTGAC--TCTPG 514
Score = 30.0 bits (66), Expect = 1.0
Identities = 32/149 (21%), Positives = 39/149 (26%), Gaps = 44/149 (29%)
Query: 24 KKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQ 83
K Q G G C C +GC R G R C CP G +G+
Sbjct: 526 KGQFGEGCASRCD----CDHSDGCDPVHGRCQCQAGWMGAR----CHLSCPEGLWGVNCS 577
Query: 84 EVNRCK---------------------KCGATCE-----------SCFSQDFCIRCKRQF 111
CK C +C+ C + FC
Sbjct: 578 NTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTC 637
Query: 112 YLYKG----KCLPTCPPGTLAHQNTRECQ 136
Y G C CPPG + CQ
Sbjct: 638 YCLAGWTGPDCSQPCPPGHWGENCAQTCQ 666
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 35.0 bits (79), Expect = 0.032
Identities = 27/110 (24%), Positives = 41/110 (37%), Gaps = 27/110 (24%)
Query: 32 GGNCTGCIICSEENGC-STCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKK 90
G +C C+ EN C TC + YG + C PGY ++
Sbjct: 202 GRSCQDVNECATENPCVQTC------------VNTYGSFICRCDPGY---------ELEE 240
Query: 91 CGATC---ESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQE 137
G C + C +F C+ + G +CPPG + + R CQ+
Sbjct: 241 DGVHCSDMDECSFSEFL--CQHECVNQPGTYFCSCPPGYILLDDNRSCQD 288
Score = 28.5 bits (62), Expect = 3.0
Identities = 21/93 (22%), Positives = 32/93 (34%), Gaps = 33/93 (35%)
Query: 78 FGIRGQEVNRC---KKCGATCESCFSQDFCIR--------CKRQFYLYKGKCLP------ 120
FG + E N+C +C C CI C ++L +G+CL
Sbjct: 115 FGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRY 174
Query: 121 ----------------TCPPGTLAHQNTRECQE 137
TC PG +++ R CQ+
Sbjct: 175 GYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQD 207
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 35.0 bits (79), Expect = 0.032
Identities = 27/80 (33%), Positives = 38/80 (47%), Gaps = 16/80 (20%)
Query: 68 KCLHDCPPGYF-GIRG--QEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPP 124
+C+ DC PGY G G +V+ C++ G E C +Q RC+ Y +C P C P
Sbjct: 919 RCVRDCDPGYHAGPEGTCDDVDECQEYGP--EICGAQ----RCENTPGSY--RCTPACDP 970
Query: 125 GTL-----AHQNTRECQERS 139
G Q+ EC+ RS
Sbjct: 971 GYQPTPGGGCQDVDECRNRS 990
>gi|110347412 latent transforming growth factor beta binding protein 4
isoform b [Homo sapiens]
Length = 1587
Score = 35.0 bits (79), Expect = 0.032
Identities = 27/80 (33%), Positives = 38/80 (47%), Gaps = 16/80 (20%)
Query: 68 KCLHDCPPGYF-GIRG--QEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPP 124
+C+ DC PGY G G +V+ C++ G E C +Q RC+ Y +C P C P
Sbjct: 949 RCVRDCDPGYHAGPEGTCDDVDECQEYGP--EICGAQ----RCENTPGSY--RCTPACDP 1000
Query: 125 GTL-----AHQNTRECQERS 139
G Q+ EC+ RS
Sbjct: 1001 GYQPTPGGGCQDVDECRNRS 1020
>gi|110347431 latent transforming growth factor beta binding protein 4
isoform a [Homo sapiens]
Length = 1624
Score = 35.0 bits (79), Expect = 0.032
Identities = 27/80 (33%), Positives = 38/80 (47%), Gaps = 16/80 (20%)
Query: 68 KCLHDCPPGYF-GIRG--QEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPP 124
+C+ DC PGY G G +V+ C++ G E C +Q RC+ Y +C P C P
Sbjct: 986 RCVRDCDPGYHAGPEGTCDDVDECQEYGP--EICGAQ----RCENTPGSY--RCTPACDP 1037
Query: 125 GTL-----AHQNTRECQERS 139
G Q+ EC+ RS
Sbjct: 1038 GYQPTPGGGCQDVDECRNRS 1057
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.327 0.144 0.483
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,550,179
Number of Sequences: 37866
Number of extensions: 433704
Number of successful extensions: 2263
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 77
Number of HSP's that attempted gapping in prelim test: 1939
Number of HSP's gapped (non-prelim): 313
length of query: 172
length of database: 18,247,518
effective HSP length: 95
effective length of query: 77
effective length of database: 14,650,248
effective search space: 1128069096
effective search space used: 1128069096
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.