BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|8923769 histone deacetylase 8 [Homo sapiens] (377 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|8923769 histone deacetylase 8 [Homo sapiens] 780 0.0 gi|116284376 histone deacetylase 2 [Homo sapiens] 322 3e-88 gi|13128860 histone deacetylase 1 [Homo sapiens] 322 5e-88 gi|13128862 histone deacetylase 3 [Homo sapiens] 313 2e-85 gi|153085395 histone deacetylase 4 [Homo sapiens] 107 1e-23 gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] 107 1e-23 gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] 107 1e-23 gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] 107 1e-23 gi|13128864 histone deacetylase 6 [Homo sapiens] 107 2e-23 gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 96 5e-20 gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] 96 5e-20 gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] 94 2e-19 gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 94 2e-19 gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] 92 1e-18 gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] 74 2e-13 gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] 74 2e-13 gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] 72 6e-13 gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] 70 3e-12 gi|223633967 hypothetical protein LOC400696 [Homo sapiens] 29 6.1 gi|194328685 myosin IB isoform 1 [Homo sapiens] 29 7.9 gi|44889481 myosin IB isoform 2 [Homo sapiens] 29 7.9 gi|240120050 myosin IB isoform 1 [Homo sapiens] 29 7.9 >gi|8923769 histone deacetylase 8 [Homo sapiens] Length = 377 Score = 780 bits (2015), Expect = 0.0 Identities = 377/377 (100%), Positives = 377/377 (100%) Query: 1 MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK 60 MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK Sbjct: 1 MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK 60 Query: 61 VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI 120 VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI Sbjct: 61 VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI 120 Query: 121 TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH 180 TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH Sbjct: 121 TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH 180 Query: 181 HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY 240 HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY Sbjct: 181 HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY 240 Query: 241 YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI 300 YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI Sbjct: 241 YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI 300 Query: 301 LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH 360 LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH Sbjct: 301 LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH 360 Query: 361 RIQQILNYIKGNLKHVV 377 RIQQILNYIKGNLKHVV Sbjct: 361 RIQQILNYIKGNLKHVV 377 >gi|116284376 histone deacetylase 2 [Homo sapiens] Length = 582 Score = 322 bits (826), Expect = 3e-88 Identities = 148/341 (43%), Positives = 227/341 (66%), Gaps = 2/341 (0%) Query: 35 PKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSI 94 P R M H+L+ Y L+++M I +P A+ EEM +H+D Y++ L+ + + ++ + Sbjct: 127 PHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQM 186 Query: 95 E-YGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFC 153 + + +G DCP +G+F++ G ++ A L +A+NW+GG HHAKK EASGFC Sbjct: 187 QRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFC 246 Query: 154 YLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGD 213 Y+ND VL IL L + +R+LY+D+D+HHGDGVE+AF T +VMTVS HK+ +FPGTGD Sbjct: 247 YVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGE-YFPGTGD 305 Query: 214 VSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDP 273 + D+G GKG+YY+VN P++DGI DE Y QI + ++ +V + + P AVVLQ GAD+++GD Sbjct: 306 LRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDR 365 Query: 274 MCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPD 333 + FN+T G KC++ + + L L+LGGGGY + N ARCWTY T V L + +E+P Sbjct: 366 LGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPY 425 Query: 334 HEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLK 374 +++F +GPD+ L I+PS ++N P +++I + NL+ Sbjct: 426 NDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLR 466 >gi|13128860 histone deacetylase 1 [Homo sapiens] Length = 482 Score = 322 bits (824), Expect = 5e-88 Identities = 147/341 (43%), Positives = 227/341 (66%), Gaps = 2/341 (0%) Query: 35 PKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSI 94 P R M H+L+ Y L+++M I +P A+ EEM +H+D Y++ L+ + + ++ + Sbjct: 32 PHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQM 91 Query: 95 E-YGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFC 153 + + +G DCP +G+F++ G ++ +A L +A+NW+GG HHAKK EASGFC Sbjct: 92 QRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFC 151 Query: 154 YLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGD 213 Y+ND VL IL L + +R+LY+D+D+HHGDGVE+AF T +VMTVS HK+ +FPGTGD Sbjct: 152 YVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGE-YFPGTGD 210 Query: 214 VSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDP 273 + D+G GKG+YY+VN P++DGI DE Y I + V+ +V + F P AVVLQ G+D+++GD Sbjct: 211 LRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDR 270 Query: 274 MCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPD 333 + FN+T G KC++++ + L L+LGGGGY + N ARCWTY T V L + +E+P Sbjct: 271 LGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPY 330 Query: 334 HEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLK 374 +++F +GPD+ L I+PS ++N +++I + NL+ Sbjct: 331 NDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLR 371 >gi|13128862 histone deacetylase 3 [Homo sapiens] Length = 428 Score = 313 bits (802), Expect = 2e-85 Identities = 148/342 (43%), Positives = 220/342 (64%), Gaps = 2/342 (0%) Query: 35 PKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSI 94 P R ++ HSL+ Y L+K+M + KP AS +M FH++ Y+ LQ+VS S+ Sbjct: 26 PHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSL 85 Query: 95 E-YGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFC 153 + +G DCP G+F++ + GA++ A L + +C +AINW+GG HHAKK EASGFC Sbjct: 86 NAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFC 145 Query: 154 YLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGD 213 Y+ND V+GIL L + R+LY+D+D+HHGDGV++AF T +VMTVS HK+ FFPGTGD Sbjct: 146 YVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGD 205 Query: 214 VSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDP 273 + +VG GRYY +NVP++DGI D+ Y + + V+ +V + P +VLQ GAD++ D Sbjct: 206 MYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDR 265 Query: 274 MCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPD 333 + FN++ G G+C++Y+ + + L+LGGGGY + N ARCWTY T +++ + +S E+P Sbjct: 266 LGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPY 325 Query: 334 HEFFTAYGPDYVLEITPSCR-PDRNEPHRIQQILNYIKGNLK 374 E+F + PD+ L S R ++N + QI I NLK Sbjct: 326 SEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLK 367 >gi|153085395 histone deacetylase 4 [Homo sapiens] Length = 1084 Score = 107 bits (268), Expect = 1e-23 Identities = 89/327 (27%), Positives = 152/327 (46%), Gaps = 63/327 (19%) Query: 28 CDSLAKIPKRASMVHSL---IEAYALHKQMRIVKPKVASMEEMATFHTDAYLQ------- 77 C S + P+ A + S+ ++ L + ++ + A++EE+ T H++A+ Sbjct: 669 CGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPL 728 Query: 78 HLQKVSQEGDDDHPDSIEY-----GLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCK 132 + QK+ + S+ G+G D ++ I++ + G A + A C+++ + K Sbjct: 729 NRQKLDSKKLLGSLASVFVRLPCGGVGVD---SDTIWNEVHSAGAARL-AVGCVVELVFK 784 Query: 133 VAIN-WSGGW-------HHAKKDEASGFCYLNDAVLG--ILRLRRKFERILYVDLDLHHG 182 VA G+ HHA++ GFCY N + +L+ R +IL VD D+HHG Sbjct: 785 VATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHG 844 Query: 183 DGVEDAFSFTSKVMTVSLHKFSPG-FFPGTGDVSDVGLGKGRYYSVNVPIQDGIQ----D 237 +G + AF V+ +SLH++ G FFPG+G +VG G G ++VN+ G+ D Sbjct: 845 NGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGD 904 Query: 238 EKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLA 297 +Y +V+ + F P V++ G D + G P TP+ Sbjct: 905 AEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHP------TPL--------------- 943 Query: 298 TLILGGGGYNLANTARCWTYLTGVILG 324 GGYNL +ARC+ YLT ++G Sbjct: 944 ------GGYNL--SARCFGYLTKQLMG 962 >gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] Length = 1069 Score = 107 bits (268), Expect = 1e-23 Identities = 93/362 (25%), Positives = 167/362 (46%), Gaps = 42/362 (11%) Query: 1 MEEPEEPADS-GQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRI 56 M+ P +P + G + P+ + ++ +C + P+ A + S+ ++ L + Sbjct: 626 MDRPLQPGSATGIAYDPLML---KHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCER 682 Query: 57 VKPKVASMEEMATFHTDAYL----------QHLQKVSQEGDDDHPDSIEY---GLGYDCP 103 ++ + AS+EE+ H++ + Q L GDD GLG D Sbjct: 683 IQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVD-- 740 Query: 104 ATEGIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW-------HHAKKDEASGFCYL 155 ++ I++ + G A + A C+I+ KVA G+ HHA++ A GFC+ Sbjct: 741 -SDTIWNELHSSGAARM-AVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFF 798 Query: 156 NDAVLGILRLRRKFE--RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTG 212 N + LR + +IL VDLD+HHG+G + AF ++ +SLH++ G FFPG+G Sbjct: 799 NSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSG 858 Query: 213 DVSDVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQAFNPKAVVLQLGADT 268 ++VG G G Y++N+ G+ D +Y + +++K V + F+P V++ G D Sbjct: 859 APNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDA 918 Query: 269 IAG--DPMCSFNMTPVGIGKCLKYILQWQLATLILG-GGGYNLANTARCWTYLTGVILGK 325 + G P+ + +T G K ++ ++L GG++L +LG Sbjct: 919 LEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGN 978 Query: 326 TL 327 L Sbjct: 979 EL 980 >gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] Length = 1011 Score = 107 bits (268), Expect = 1e-23 Identities = 93/362 (25%), Positives = 167/362 (46%), Gaps = 42/362 (11%) Query: 1 MEEPEEPADS-GQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRI 56 M+ P +P + G + P+ + ++ +C + P+ A + S+ ++ L + Sbjct: 623 MDRPLQPGSATGIAYDPLML---KHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCER 679 Query: 57 VKPKVASMEEMATFHTDAYL----------QHLQKVSQEGDDDHPDSIEY---GLGYDCP 103 ++ + AS+EE+ H++ + Q L GDD GLG D Sbjct: 680 IQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVD-- 737 Query: 104 ATEGIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW-------HHAKKDEASGFCYL 155 ++ I++ + G A + A C+I+ KVA G+ HHA++ A GFC+ Sbjct: 738 -SDTIWNELHSSGAARM-AVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFF 795 Query: 156 NDAVLGILRLRRKFE--RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTG 212 N + LR + +IL VDLD+HHG+G + AF ++ +SLH++ G FFPG+G Sbjct: 796 NSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSG 855 Query: 213 DVSDVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQAFNPKAVVLQLGADT 268 ++VG G G Y++N+ G+ D +Y + +++K V + F+P V++ G D Sbjct: 856 APNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDA 915 Query: 269 IAG--DPMCSFNMTPVGIGKCLKYILQWQLATLILG-GGGYNLANTARCWTYLTGVILGK 325 + G P+ + +T G K ++ ++L GG++L +LG Sbjct: 916 LEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGN 975 Query: 326 TL 327 L Sbjct: 976 EL 977 >gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] Length = 1066 Score = 107 bits (268), Expect = 1e-23 Identities = 93/362 (25%), Positives = 167/362 (46%), Gaps = 42/362 (11%) Query: 1 MEEPEEPADS-GQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRI 56 M+ P +P + G + P+ + ++ +C + P+ A + S+ ++ L + Sbjct: 623 MDRPLQPGSATGIAYDPLML---KHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCER 679 Query: 57 VKPKVASMEEMATFHTDAYL----------QHLQKVSQEGDDDHPDSIEY---GLGYDCP 103 ++ + AS+EE+ H++ + Q L GDD GLG D Sbjct: 680 IQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVD-- 737 Query: 104 ATEGIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW-------HHAKKDEASGFCYL 155 ++ I++ + G A + A C+I+ KVA G+ HHA++ A GFC+ Sbjct: 738 -SDTIWNELHSSGAARM-AVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFF 795 Query: 156 NDAVLGILRLRRKFE--RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTG 212 N + LR + +IL VDLD+HHG+G + AF ++ +SLH++ G FFPG+G Sbjct: 796 NSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSG 855 Query: 213 DVSDVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQAFNPKAVVLQLGADT 268 ++VG G G Y++N+ G+ D +Y + +++K V + F+P V++ G D Sbjct: 856 APNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDA 915 Query: 269 IAG--DPMCSFNMTPVGIGKCLKYILQWQLATLILG-GGGYNLANTARCWTYLTGVILGK 325 + G P+ + +T G K ++ ++L GG++L +LG Sbjct: 916 LEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGN 975 Query: 326 TL 327 L Sbjct: 976 EL 977 >gi|13128864 histone deacetylase 6 [Homo sapiens] Length = 1215 Score = 107 bits (267), Expect = 2e-23 Identities = 84/303 (27%), Positives = 137/303 (45%), Gaps = 15/303 (4%) Query: 33 KIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDD-HP 91 ++P+R + +E L + + P+ A+ E+ T H+ Y+ HL+ + + H Sbjct: 502 EVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHR 561 Query: 92 DSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDG--MCKVAINWSGGWHHAKKDEA 149 +S + Y CP+T F A GA + ++ G + A+ G HHA++D A Sbjct: 562 ESSNFDSIYICPST---FACAQLATGAACRLVEAVLSGEVLNGAAVVRPPG-HHAEQDAA 617 Query: 150 SGFCYLNDAVLGILRLRR---KFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG 206 GFC+ N + + RIL VD D+HHG+G + F V+ VSLH++ G Sbjct: 618 CGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHG 677 Query: 207 -FFP--GTGDVSDVGLGKGRYYSVNVPIQ-DGIQDEKYYQICESVLKEVYQAFNPKAVVL 262 FFP G S +G G ++VNV + D Y ++ + FNP+ V++ Sbjct: 678 TFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLV 737 Query: 263 QLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLIL-GGGGYNLANTARCWTYLTGV 321 G D GDP+ ++P G ++ +IL GGYNL + + T Sbjct: 738 SAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRS 797 Query: 322 ILG 324 +LG Sbjct: 798 LLG 800 Score = 91.7 bits (226), Expect = 1e-18 Identities = 77/300 (25%), Positives = 123/300 (41%), Gaps = 34/300 (11%) Query: 29 DSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDD 88 DS + P+R + + L + + + A EE+ H+ Y+ ++ + Sbjct: 103 DSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEG 162 Query: 89 D-------------HPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAI 135 + HP+S C A+ + A+ GA I +I Sbjct: 163 ELRVLADTYDSVYLHPNSYSCA----CLASGSVLRLVDAVLGAEIRNGMAII-------- 210 Query: 136 NWSGGWHHAKKDEASGFCYLNDAVLGILRLRRK--FERILYVDLDLHHGDGVEDAFSFTS 193 HHA+ G+C N + ++K R+L VD D+HHG G + F Sbjct: 211 --RPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDP 268 Query: 194 KVMTVSLHKFSPG-FFP--GTGDVSDVGLGKGRYYSVNVP-IQDGIQDEKYYQICESVLK 249 V+ S+H++ G F+P + S G G+G+ Y++NVP Q G++D Y VL Sbjct: 269 SVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLL 328 Query: 250 EVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILG-GGGYNL 308 V F P+ V++ G D + GDP TP G + ++ LIL GGYNL Sbjct: 329 PVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNL 388 >gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] Length = 1123 Score = 95.9 bits (237), Expect = 5e-20 Identities = 87/346 (25%), Positives = 160/346 (46%), Gaps = 41/346 (11%) Query: 4 PEEPADSGQSLVPVY-IYSPEYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRIVKP 59 P++P + VY + ++ MC + P+ A + S+ ++ L + ++ Sbjct: 674 PDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRG 733 Query: 60 KVASMEEMATFHTDAY--LQHLQKVSQEGDDDH----PDSIEY-------GLGYDCPATE 106 + A+++E+ T H++ + L ++++ D P S + G+G D Sbjct: 734 RKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVW 793 Query: 107 GIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW-------HHAKKDEASGFCYLNDA 158 ++A+ A CL++ KVA G+ HHA++ A GFC+ N Sbjct: 794 NEMHSSSAVR----MAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSV 849 Query: 159 VLGILRLRRKFE--RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTGDVS 215 + L++K ++L VD D+HHG+G + AF V+ +SLH++ G FFPG+G Sbjct: 850 AITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPE 909 Query: 216 DVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAG 271 +VG G G Y+VNV G+ D +Y +V+ + F+P V++ G D + G Sbjct: 910 EVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEG 969 Query: 272 --DPMCSFNMTPVGIGKCLKYILQWQLATLILG-GGGYNLANTARC 314 P+ +++T G + ++ ++L GG++L TA C Sbjct: 970 HLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDL--TAIC 1013 >gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] Length = 1122 Score = 95.9 bits (237), Expect = 5e-20 Identities = 87/346 (25%), Positives = 160/346 (46%), Gaps = 41/346 (11%) Query: 4 PEEPADSGQSLVPVY-IYSPEYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRIVKP 59 P++P + VY + ++ MC + P+ A + S+ ++ L + ++ Sbjct: 673 PDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRG 732 Query: 60 KVASMEEMATFHTDAY--LQHLQKVSQEGDDDH----PDSIEY-------GLGYDCPATE 106 + A+++E+ T H++ + L ++++ D P S + G+G D Sbjct: 733 RKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVW 792 Query: 107 GIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW-------HHAKKDEASGFCYLNDA 158 ++A+ A CL++ KVA G+ HHA++ A GFC+ N Sbjct: 793 NEMHSSSAVR----MAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSV 848 Query: 159 VLGILRLRRKFE--RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTGDVS 215 + L++K ++L VD D+HHG+G + AF V+ +SLH++ G FFPG+G Sbjct: 849 AITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPE 908 Query: 216 DVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAG 271 +VG G G Y+VNV G+ D +Y +V+ + F+P V++ G D + G Sbjct: 909 EVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEG 968 Query: 272 --DPMCSFNMTPVGIGKCLKYILQWQLATLILG-GGGYNLANTARC 314 P+ +++T G + ++ ++L GG++L TA C Sbjct: 969 HLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDL--TAIC 1012 >gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] Length = 954 Score = 94.0 bits (232), Expect = 2e-19 Identities = 65/190 (34%), Positives = 93/190 (48%), Gaps = 26/190 (13%) Query: 142 HHAKKDEASGFCYLNDAVLGILRLRR--KFERILYVDLDLHHGDGVEDAFSFTSKVMTVS 199 HHA A GFC+ N + +L++ K +IL VD D+HHG+G + F V+ +S Sbjct: 671 HHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYIS 730 Query: 200 LHKFSPG-FFPGTGDVSDVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQA 254 LH+ G FFPG+G V +VG G G ++VNV G+ D +Y V+ + + Sbjct: 731 LHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIARE 790 Query: 255 FNPKAVVLQLGADTIAGDPMCSFNMTPVG----IGKCLKYILQWQLATLILGG------G 304 F+P V++ G D G P P+G KC Y+ Q QL L G G Sbjct: 791 FSPDLVLVSAGFDAAEGHP------APLGGYHVSAKCFGYMTQ-QLMNLAGGAVVLALEG 843 Query: 305 GYNLANTARC 314 G++L TA C Sbjct: 844 GHDL--TAIC 851 >gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] Length = 991 Score = 94.0 bits (232), Expect = 2e-19 Identities = 65/190 (34%), Positives = 93/190 (48%), Gaps = 26/190 (13%) Query: 142 HHAKKDEASGFCYLNDAVLGILRLRR--KFERILYVDLDLHHGDGVEDAFSFTSKVMTVS 199 HHA A GFC+ N + +L++ K +IL VD D+HHG+G + F V+ +S Sbjct: 708 HHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYIS 767 Query: 200 LHKFSPG-FFPGTGDVSDVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQA 254 LH+ G FFPG+G V +VG G G ++VNV G+ D +Y V+ + + Sbjct: 768 LHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIARE 827 Query: 255 FNPKAVVLQLGADTIAGDPMCSFNMTPVG----IGKCLKYILQWQLATLILGG------G 304 F+P V++ G D G P P+G KC Y+ Q QL L G G Sbjct: 828 FSPDLVLVSAGFDAAEGHP------APLGGYHVSAKCFGYMTQ-QLMNLAGGAVVLALEG 880 Query: 305 GYNLANTARC 314 G++L TA C Sbjct: 881 GHDL--TAIC 888 >gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] Length = 669 Score = 91.7 bits (226), Expect = 1e-18 Identities = 80/306 (26%), Positives = 139/306 (45%), Gaps = 26/306 (8%) Query: 35 PKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDD-HPDS 93 P+R + + L ++ + + AS EE+ H+ Y+ +++ G ++ S Sbjct: 28 PERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALS 87 Query: 94 IEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCK--VAINWSGGWHHAKKDEASG 151 ++ Y P+T F A GA + ++ G + +A+ G HH ++ A+G Sbjct: 88 GQFDAIYFHPST---FHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAANG 143 Query: 152 FCYLNDAVLGILRLRRK--FERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FF 208 FC N+ + ++K RIL VD D+HHG G++ F V+ S H++ G F+ Sbjct: 144 FCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFW 203 Query: 209 P--GTGDVSDVGLGKGRYYSVNVP-IQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLG 265 P D VG G+G ++VN+P Q G+ + Y +L + F+P+ V++ G Sbjct: 204 PFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAG 263 Query: 266 ADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG-------GGYNLANTARCWTYL 318 D+ GDP TP +C ++ QL ++ GG GGY+L + A Sbjct: 264 FDSAIGDPEGQMQATP----ECFAHLT--QLLQVLAGGRVCAVLEGGYHLESLAESVCMT 317 Query: 319 TGVILG 324 +LG Sbjct: 318 VQTLLG 323 >gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] Length = 347 Score = 74.3 bits (181), Expect = 2e-13 Identities = 78/307 (25%), Positives = 124/307 (40%), Gaps = 27/307 (8%) Query: 19 IYSPEYVSMCDSLAKIP-----KRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTD 73 +YSP Y L K+ K +++ L E L M +V+ + AS E++ HT Sbjct: 19 VYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSM-LVEAREASEEDLLVVHTR 77 Query: 74 AYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKV 133 YL L+ + + + + G TI A + ++ Sbjct: 78 RYLNELKWSFAVATITEIPPVIFLPNF--LVQRKVLRPLRTQTGGTIMAGKLAVERGW-- 133 Query: 134 AINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFE---RILYVDLDLHHGDGVEDAFS 190 AIN GG+HH D GFC D L I L + E R +DLD H G+G E F Sbjct: 134 AINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFM 193 Query: 191 FTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKE 250 +V + + ++ +PG K V ++ G +D++Y E +K+ Sbjct: 194 DDKRVYIMDV--YNRHIYPGDRFAKQAIRRK-------VELEWGTEDDEYLDKVERNIKK 244 Query: 251 VYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGK----CLKYILQWQLATLILGGGGY 306 Q P VV G D + GD + +++P GI K + + ++ L++ GGY Sbjct: 245 SLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGY 304 Query: 307 NLANTAR 313 TAR Sbjct: 305 Q-KRTAR 310 >gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] Length = 879 Score = 74.3 bits (181), Expect = 2e-13 Identities = 66/245 (26%), Positives = 116/245 (47%), Gaps = 35/245 (14%) Query: 1 MEEPEEPADS-GQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRI 56 M+ P +P + G + P+ + ++ +C + P+ A + S+ ++ L + Sbjct: 623 MDRPLQPGSATGIAYDPLML---KHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCER 679 Query: 57 VKPKVASMEEMATFHTDAYL----------QHLQKVSQEGDDDHPDSIEY---GLGYDCP 103 ++ + AS+EE+ H++ + Q L GDD GLG D Sbjct: 680 IQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVD-- 737 Query: 104 ATEGIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW-------HHAKKDEASGFCYL 155 ++ I++ + G A + A C+I+ KVA G+ HHA++ A GFC+ Sbjct: 738 -SDTIWNELHSSGAARM-AVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFF 795 Query: 156 NDAVLGILRLRRKFE--RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTG 212 N + LR + +IL VDLD+HHG+G + AF ++ +SLH++ G FFPG+G Sbjct: 796 NSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSG 855 Query: 213 DVSDV 217 ++V Sbjct: 856 APNEV 860 >gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] Length = 296 Score = 72.4 bits (176), Expect = 6e-13 Identities = 72/285 (25%), Positives = 114/285 (40%), Gaps = 45/285 (15%) Query: 36 KRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIE 95 K +++ L E L M +V+ + AS E++ HT YL L++ Sbjct: 13 KWGKVINFLKEEKLLSDSM-LVEAREASEEDLLVVHTRRYLNELKRK------------- 58 Query: 96 YGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYL 155 + G TI A + ++ AIN GG+HH D GFC Sbjct: 59 ------------VLRPLRTQTGGTIMAGKLAVERGW--AINVGGGFHHCSSDRGGGFCAY 104 Query: 156 NDAVLGILRLRRKFE---RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTG 212 D L I L + E R +DLD H G+G E F +V + + ++ +PG Sbjct: 105 ADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDV--YNRHIYPGDR 162 Query: 213 DVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGD 272 K V ++ G +D++Y E +K+ Q P VV G D + GD Sbjct: 163 FAKQAIRRK-------VELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGD 215 Query: 273 PMCSFNMTPVGIGK----CLKYILQWQLATLILGGGGYNLANTAR 313 + +++P GI K + + ++ L++ GGY TAR Sbjct: 216 RLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQ-KRTAR 259 >gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] Length = 649 Score = 70.1 bits (170), Expect = 3e-12 Identities = 54/204 (26%), Positives = 96/204 (47%), Gaps = 12/204 (5%) Query: 35 PKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDD-HPDS 93 P+R + + L ++ + + AS EE+ H+ Y+ +++ G ++ S Sbjct: 28 PERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALS 87 Query: 94 IEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCK--VAINWSGGWHHAKKDEASG 151 ++ Y P+T F A GA + ++ G + +A+ G HH ++ A+G Sbjct: 88 GQFDAIYFHPST---FHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAANG 143 Query: 152 FCYLNDAVLGILRLRRK--FERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FF 208 FC N+ + ++K RIL VD D+HHG G++ F V+ S H++ G F+ Sbjct: 144 FCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFW 203 Query: 209 P--GTGDVSDVGLGKGRYYSVNVP 230 P D VG G+G ++VN+P Sbjct: 204 PFLRESDADAVGRGQGLGFTVNLP 227 >gi|223633967 hypothetical protein LOC400696 [Homo sapiens] Length = 151 Score = 29.3 bits (64), Expect = 6.1 Identities = 16/36 (44%), Positives = 21/36 (58%), Gaps = 4/36 (11%) Query: 228 NVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQ 263 N+P QDG K + +C SVL + YQ F + VLQ Sbjct: 80 NMPFQDG----KPFNLCISVLADEYQPFRIISYVLQ 111 >gi|194328685 myosin IB isoform 1 [Homo sapiens] Length = 1136 Score = 28.9 bits (63), Expect = 7.9 Identities = 14/36 (38%), Positives = 22/36 (61%) Query: 156 NDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSF 191 ++ +L L+L R F R Y+ LD +GV+DA +F Sbjct: 216 SEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANF 251 >gi|44889481 myosin IB isoform 2 [Homo sapiens] Length = 1078 Score = 28.9 bits (63), Expect = 7.9 Identities = 14/36 (38%), Positives = 22/36 (61%) Query: 156 NDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSF 191 ++ +L L+L R F R Y+ LD +GV+DA +F Sbjct: 216 SEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANF 251 >gi|240120050 myosin IB isoform 1 [Homo sapiens] Length = 1136 Score = 28.9 bits (63), Expect = 7.9 Identities = 14/36 (38%), Positives = 22/36 (61%) Query: 156 NDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSF 191 ++ +L L+L R F R Y+ LD +GV+DA +F Sbjct: 216 SEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANF 251 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.138 0.426 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,200,658 Number of Sequences: 37866 Number of extensions: 686574 Number of successful extensions: 1276 Number of sequences better than 10.0: 22 Number of HSP's better than 10.0 without gapping: 21 Number of HSP's successfully gapped in prelim test: 1 Number of HSP's that attempted gapping in prelim test: 1208 Number of HSP's gapped (non-prelim): 28 length of query: 377 length of database: 18,247,518 effective HSP length: 104 effective length of query: 273 effective length of database: 14,309,454 effective search space: 3906480942 effective search space used: 3906480942 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.