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Search of human proteins with 14150171
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14150171 THO complex 3 [Homo sapiens]
(351 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14150171 THO complex 3 [Homo sapiens] 736 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 96 6e-20
gi|16554627 WD repeat domain 5 [Homo sapiens] 96 6e-20
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 92 7e-19
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 92 7e-19
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 92 7e-19
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 92 7e-19
gi|26665869 WD repeat domain 51B [Homo sapiens] 89 5e-18
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 89 6e-18
gi|23199987 WD repeat domain 5B [Homo sapiens] 89 6e-18
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 86 5e-17
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 86 5e-17
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 86 5e-17
gi|19913367 transducin beta-like 1Y [Homo sapiens] 86 7e-17
gi|19913365 transducin beta-like 1Y [Homo sapiens] 86 7e-17
gi|15150805 transducin beta-like 1Y [Homo sapiens] 86 7e-17
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 84 1e-16
gi|32189425 WD repeat domain 69 [Homo sapiens] 79 5e-15
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 76 4e-14
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 73 4e-13
gi|13376840 WD repeat domain 61 [Homo sapiens] 73 4e-13
gi|113865883 WD repeat domain 38 [Homo sapiens] 72 7e-13
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 72 1e-12
gi|4757988 WD repeat domain 39 [Homo sapiens] 72 1e-12
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 71 1e-12
gi|21071067 TBP-associated factor 5 [Homo sapiens] 68 1e-11
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 67 2e-11
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 67 2e-11
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 67 3e-11
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 66 5e-11
>gi|14150171 THO complex 3 [Homo sapiens]
Length = 351
Score = 736 bits (1899), Expect = 0.0
Identities = 351/351 (100%), Positives = 351/351 (100%)
Query: 1 MAVPAAAMGPSALGQSGPGSMAPWCSVSSGPSRYVLGMQELFRGHSKTREFLAHSAKVHS 60
MAVPAAAMGPSALGQSGPGSMAPWCSVSSGPSRYVLGMQELFRGHSKTREFLAHSAKVHS
Sbjct: 1 MAVPAAAMGPSALGQSGPGSMAPWCSVSSGPSRYVLGMQELFRGHSKTREFLAHSAKVHS 60
Query: 61 VAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASG 120
VAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASG
Sbjct: 61 VAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASG 120
Query: 121 DKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQ 180
DKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQ
Sbjct: 121 DKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQ 180
Query: 181 FKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFA 240
FKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFA
Sbjct: 181 FKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFA 240
Query: 241 TGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDK 300
TGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDK
Sbjct: 241 TGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDK 300
Query: 301 LWEVQCESPTFTVAWHPKRPLLAFACDDKDGKYDSSREAGTVKLFGLPNDS 351
LWEVQCESPTFTVAWHPKRPLLAFACDDKDGKYDSSREAGTVKLFGLPNDS
Sbjct: 301 LWEVQCESPTFTVAWHPKRPLLAFACDDKDGKYDSSREAGTVKLFGLPNDS 351
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 95.5 bits (236), Expect = 6e-20
Identities = 74/284 (26%), Positives = 136/284 (47%), Gaps = 10/284 (3%)
Query: 54 HSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPD 113
H+ V SV +S +G LAS S DK ++ + E GH + + W S+ +
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF--EKTISGHKLGISDVAWS-SDSN 100
Query: 114 LFVTASGDKTIRIWDVRTTKCIATVNTKGENINIC-WSPDGQTIAVGNKDDVVTFIDAKT 172
L V+AS DKT++IWDV + KC+ T+ + C ++P I G+ D+ V D KT
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 173 HRS-KAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCIC-I 230
+ K V+ + +N D ++ ++ +G I + ++++ + + +
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 231 KFDPMGKYFATGSADALVSLWDVDELVCVRCFS--RLDWPVRTLSFS-HDGKMLASASED 287
KF P GKY + D + LWD + C++ ++ + + +FS GK + S SED
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 280
Query: 288 HFIDIAEVETGDKLWEVQCESP-TFTVAWHPKRPLLAFACDDKD 330
+ + I ++T + + ++Q + + A HP ++A A + D
Sbjct: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALEND 324
Score = 45.4 bits (106), Expect = 7e-05
Identities = 32/126 (25%), Positives = 58/126 (46%), Gaps = 7/126 (5%)
Query: 219 SINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDG 278
++ H +KF P G++ A+ SAD L+ +W + + S + +++S D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 279 KMLASASEDHFIDIAEVETGDKLWEVQCESP-TFTVAWHPKRPLLAFACDDKDGKYDSSR 337
+L SAS+D + I +V +G L ++ S F ++P+ L+ G +D S
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV------SGSFDESV 153
Query: 338 EAGTVK 343
VK
Sbjct: 154 RIWDVK 159
Score = 34.3 bits (77), Expect = 0.17
Identities = 31/125 (24%), Positives = 57/125 (45%), Gaps = 8/125 (6%)
Query: 53 AHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNP 112
AHS V +V ++ DG + S S+D ++ + +K V + + P N
Sbjct: 169 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK-TLIDDDNPPVSFVKFSP-NG 226
Query: 113 DLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPD-----GQTIAVGNKDDVVTF 167
+ A+ D T+++WD KC+ T T +N C + G+ I G++D++V
Sbjct: 227 KYILAATLDNTLKLWDYSKGKCLKTY-TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285
Query: 168 IDAKT 172
+ +T
Sbjct: 286 WNLQT 290
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 95.5 bits (236), Expect = 6e-20
Identities = 74/284 (26%), Positives = 136/284 (47%), Gaps = 10/284 (3%)
Query: 54 HSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPD 113
H+ V SV +S +G LAS S DK ++ + E GH + + W S+ +
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF--EKTISGHKLGISDVAWS-SDSN 100
Query: 114 LFVTASGDKTIRIWDVRTTKCIATVNTKGENINIC-WSPDGQTIAVGNKDDVVTFIDAKT 172
L V+AS DKT++IWDV + KC+ T+ + C ++P I G+ D+ V D KT
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 173 HRS-KAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCIC-I 230
+ K V+ + +N D ++ ++ +G I + ++++ + + +
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 231 KFDPMGKYFATGSADALVSLWDVDELVCVRCFS--RLDWPVRTLSFS-HDGKMLASASED 287
KF P GKY + D + LWD + C++ ++ + + +FS GK + S SED
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 280
Query: 288 HFIDIAEVETGDKLWEVQCESP-TFTVAWHPKRPLLAFACDDKD 330
+ + I ++T + + ++Q + + A HP ++A A + D
Sbjct: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALEND 324
Score = 45.4 bits (106), Expect = 7e-05
Identities = 32/126 (25%), Positives = 58/126 (46%), Gaps = 7/126 (5%)
Query: 219 SINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDG 278
++ H +KF P G++ A+ SAD L+ +W + + S + +++S D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 279 KMLASASEDHFIDIAEVETGDKLWEVQCESP-TFTVAWHPKRPLLAFACDDKDGKYDSSR 337
+L SAS+D + I +V +G L ++ S F ++P+ L+ G +D S
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV------SGSFDESV 153
Query: 338 EAGTVK 343
VK
Sbjct: 154 RIWDVK 159
Score = 34.3 bits (77), Expect = 0.17
Identities = 31/125 (24%), Positives = 57/125 (45%), Gaps = 8/125 (6%)
Query: 53 AHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNP 112
AHS V +V ++ DG + S S+D ++ + +K V + + P N
Sbjct: 169 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK-TLIDDDNPPVSFVKFSP-NG 226
Query: 113 DLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPD-----GQTIAVGNKDDVVTF 167
+ A+ D T+++WD KC+ T T +N C + G+ I G++D++V
Sbjct: 227 KYILAATLDNTLKLWDYSKGKCLKTY-TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285
Query: 168 IDAKT 172
+ +T
Sbjct: 286 WNLQT 290
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 92.0 bits (227), Expect = 7e-19
Identities = 80/306 (26%), Positives = 133/306 (43%), Gaps = 21/306 (6%)
Query: 46 SKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKD------RLVKENNYR--G 97
SK H ++V AW+ LASGS D TA ++ L ++ +LV + R G
Sbjct: 172 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 231
Query: 98 H----GDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDG 153
H V L W+ +N L T S D RIW KG + W+ G
Sbjct: 232 HDVPSNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKG 290
Query: 154 QTIAVGNKDDVVTFIDAKTHRSKAEEQFKFE---VNEISWNNDNNMFFLTNGNGCINILS 210
I D DA H +A++QF F ++ W N N F + + CI++
Sbjct: 291 NYILSAGVDKTTIIWDA--HTGEAKQQFPFHSAPALDVDWQN-NTTFASCSTDMCIHVCR 347
Query: 211 YPELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVR 270
+PV++ H + IK+DP G A+ S D + +W + + VC+ + +
Sbjct: 348 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 407
Query: 271 TLSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRPLLAFACDDKD 330
T+ +S G ++ + + + A ++ +LW+++ T T+ H + P+ + A D
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKH-QEPVYSVAF-SPD 465
Query: 331 GKYDSS 336
GKY +S
Sbjct: 466 GKYLAS 471
Score = 50.1 bits (118), Expect = 3e-06
Identities = 30/83 (36%), Positives = 48/83 (57%), Gaps = 4/83 (4%)
Query: 48 TREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCW 107
T H V+SVA+S DG+ LASGSFDK ++ + LV ++YRG G + ++CW
Sbjct: 447 THTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV--HSYRGTG-GIFEVCW 503
Query: 108 HPSNPDLFVTASGDKTIRIWDVR 130
+ + +AS D ++ + D+R
Sbjct: 504 NARGDKVGASAS-DGSVCVLDLR 525
Score = 47.4 bits (111), Expect = 2e-05
Identities = 30/128 (23%), Positives = 56/128 (43%), Gaps = 12/128 (9%)
Query: 53 AHSAKVHSVAWSCDGRR---------LASGSFDKTASVFLLEKDRLVKENNYRGHGDSVD 103
AH+ +++++ WS G LAS SFD T ++ +E+ V + H + V
Sbjct: 401 AHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVY 458
Query: 104 QLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDD 163
+ + P L + S DK + IW+ ++ + + G +CW+ G + D
Sbjct: 459 SVAFSPDGKYL-ASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDG 517
Query: 164 VVTFIDAK 171
V +D +
Sbjct: 518 SVCVLDLR 525
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 92.0 bits (227), Expect = 7e-19
Identities = 80/306 (26%), Positives = 133/306 (43%), Gaps = 21/306 (6%)
Query: 46 SKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKD------RLVKENNYR--G 97
SK H ++V AW+ LASGS D TA ++ L ++ +LV + R G
Sbjct: 172 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 231
Query: 98 H----GDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDG 153
H V L W+ +N L T S D RIW KG + W+ G
Sbjct: 232 HDVPSNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKG 290
Query: 154 QTIAVGNKDDVVTFIDAKTHRSKAEEQFKFE---VNEISWNNDNNMFFLTNGNGCINILS 210
I D DA H +A++QF F ++ W N N F + + CI++
Sbjct: 291 NYILSAGVDKTTIIWDA--HTGEAKQQFPFHSAPALDVDWQN-NTTFASCSTDMCIHVCR 347
Query: 211 YPELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVR 270
+PV++ H + IK+DP G A+ S D + +W + + VC+ + +
Sbjct: 348 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 407
Query: 271 TLSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRPLLAFACDDKD 330
T+ +S G ++ + + + A ++ +LW+++ T T+ H + P+ + A D
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKH-QEPVYSVAF-SPD 465
Query: 331 GKYDSS 336
GKY +S
Sbjct: 466 GKYLAS 471
Score = 50.1 bits (118), Expect = 3e-06
Identities = 30/83 (36%), Positives = 48/83 (57%), Gaps = 4/83 (4%)
Query: 48 TREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCW 107
T H V+SVA+S DG+ LASGSFDK ++ + LV ++YRG G + ++CW
Sbjct: 447 THTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV--HSYRGTG-GIFEVCW 503
Query: 108 HPSNPDLFVTASGDKTIRIWDVR 130
+ + +AS D ++ + D+R
Sbjct: 504 NARGDKVGASAS-DGSVCVLDLR 525
Score = 47.4 bits (111), Expect = 2e-05
Identities = 30/128 (23%), Positives = 56/128 (43%), Gaps = 12/128 (9%)
Query: 53 AHSAKVHSVAWSCDGRR---------LASGSFDKTASVFLLEKDRLVKENNYRGHGDSVD 103
AH+ +++++ WS G LAS SFD T ++ +E+ V + H + V
Sbjct: 401 AHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVY 458
Query: 104 QLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDD 163
+ + P L + S DK + IW+ ++ + + G +CW+ G + D
Sbjct: 459 SVAFSPDGKYL-ASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDG 517
Query: 164 VVTFIDAK 171
V +D +
Sbjct: 518 SVCVLDLR 525
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 92.0 bits (227), Expect = 7e-19
Identities = 80/306 (26%), Positives = 133/306 (43%), Gaps = 21/306 (6%)
Query: 46 SKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKD------RLVKENNYR--G 97
SK H ++V AW+ LASGS D TA ++ L ++ +LV + R G
Sbjct: 223 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 282
Query: 98 H----GDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDG 153
H V L W+ +N L T S D RIW KG + W+ G
Sbjct: 283 HDVPSNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKG 341
Query: 154 QTIAVGNKDDVVTFIDAKTHRSKAEEQFKFE---VNEISWNNDNNMFFLTNGNGCINILS 210
I D DA H +A++QF F ++ W N N F + + CI++
Sbjct: 342 NYILSAGVDKTTIIWDA--HTGEAKQQFPFHSAPALDVDWQN-NTTFASCSTDMCIHVCR 398
Query: 211 YPELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVR 270
+PV++ H + IK+DP G A+ S D + +W + + VC+ + +
Sbjct: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
Query: 271 TLSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRPLLAFACDDKD 330
T+ +S G ++ + + + A ++ +LW+++ T T+ H + P+ + A D
Sbjct: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKH-QEPVYSVAF-SPD 516
Query: 331 GKYDSS 336
GKY +S
Sbjct: 517 GKYLAS 522
Score = 50.1 bits (118), Expect = 3e-06
Identities = 30/83 (36%), Positives = 48/83 (57%), Gaps = 4/83 (4%)
Query: 48 TREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCW 107
T H V+SVA+S DG+ LASGSFDK ++ + LV ++YRG G + ++CW
Sbjct: 498 THTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV--HSYRGTG-GIFEVCW 554
Query: 108 HPSNPDLFVTASGDKTIRIWDVR 130
+ + +AS D ++ + D+R
Sbjct: 555 NARGDKVGASAS-DGSVCVLDLR 576
Score = 47.4 bits (111), Expect = 2e-05
Identities = 30/128 (23%), Positives = 56/128 (43%), Gaps = 12/128 (9%)
Query: 53 AHSAKVHSVAWSCDGRR---------LASGSFDKTASVFLLEKDRLVKENNYRGHGDSVD 103
AH+ +++++ WS G LAS SFD T ++ +E+ V + H + V
Sbjct: 452 AHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVY 509
Query: 104 QLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDD 163
+ + P L + S DK + IW+ ++ + + G +CW+ G + D
Sbjct: 510 SVAFSPDGKYL-ASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDG 568
Query: 164 VVTFIDAK 171
V +D +
Sbjct: 569 SVCVLDLR 576
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 92.0 bits (227), Expect = 7e-19
Identities = 80/306 (26%), Positives = 133/306 (43%), Gaps = 21/306 (6%)
Query: 46 SKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKD------RLVKENNYR--G 97
SK H ++V AW+ LASGS D TA ++ L ++ +LV + R G
Sbjct: 223 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 282
Query: 98 H----GDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDG 153
H V L W+ +N L T S D RIW KG + W+ G
Sbjct: 283 HDVPSNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKG 341
Query: 154 QTIAVGNKDDVVTFIDAKTHRSKAEEQFKFE---VNEISWNNDNNMFFLTNGNGCINILS 210
I D DA H +A++QF F ++ W N N F + + CI++
Sbjct: 342 NYILSAGVDKTTIIWDA--HTGEAKQQFPFHSAPALDVDWQN-NTTFASCSTDMCIHVCR 398
Query: 211 YPELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVR 270
+PV++ H + IK+DP G A+ S D + +W + + VC+ + +
Sbjct: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
Query: 271 TLSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRPLLAFACDDKD 330
T+ +S G ++ + + + A ++ +LW+++ T T+ H + P+ + A D
Sbjct: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKH-QEPVYSVAF-SPD 516
Query: 331 GKYDSS 336
GKY +S
Sbjct: 517 GKYLAS 522
Score = 50.1 bits (118), Expect = 3e-06
Identities = 30/83 (36%), Positives = 48/83 (57%), Gaps = 4/83 (4%)
Query: 48 TREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCW 107
T H V+SVA+S DG+ LASGSFDK ++ + LV ++YRG G + ++CW
Sbjct: 498 THTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV--HSYRGTG-GIFEVCW 554
Query: 108 HPSNPDLFVTASGDKTIRIWDVR 130
+ + +AS D ++ + D+R
Sbjct: 555 NARGDKVGASAS-DGSVCVLDLR 576
Score = 47.4 bits (111), Expect = 2e-05
Identities = 30/128 (23%), Positives = 56/128 (43%), Gaps = 12/128 (9%)
Query: 53 AHSAKVHSVAWSCDGRR---------LASGSFDKTASVFLLEKDRLVKENNYRGHGDSVD 103
AH+ +++++ WS G LAS SFD T ++ +E+ V + H + V
Sbjct: 452 AHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVY 509
Query: 104 QLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDD 163
+ + P L + S DK + IW+ ++ + + G +CW+ G + D
Sbjct: 510 SVAFSPDGKYL-ASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDG 568
Query: 164 VVTFIDAK 171
V +D +
Sbjct: 569 SVCVLDLR 576
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 89.4 bits (220), Expect = 5e-18
Identities = 66/218 (30%), Positives = 101/218 (46%), Gaps = 11/218 (5%)
Query: 47 KTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLC 106
K EF AH+A V SV +S DG+ LA+ S DK+ V+ + + R + H +
Sbjct: 94 KFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKF- 152
Query: 107 WHPSNPD--LFVTASGDKTIRIWDVRTTKCIATVNTKGENIN-ICWSPDGQTIAVGNKDD 163
+PD L V+ S DKTI+IWD +C+ + N + ++P G IA D
Sbjct: 153 ----SPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQ 208
Query: 164 VVTFIDAKTHRSKAEEQFKFE-VNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINA 222
V D + ++ Q VN IS++ N + +G + IL E + + ++
Sbjct: 209 TVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQG 268
Query: 223 HPSNCICIKFDPMGKYFATGSADALVSLW--DVDELVC 258
H + F G+ FA+G AD V LW + DEL C
Sbjct: 269 HTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHC 306
Score = 79.3 bits (194), Expect = 5e-15
Identities = 61/250 (24%), Positives = 108/250 (43%), Gaps = 9/250 (3%)
Query: 42 FRGHSKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDS 101
F+ H++ ++ H V SV +S G LAS S D+T +++ D+ K + ++ H
Sbjct: 47 FKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWI--PDKRGKFSEFKAHTAP 104
Query: 102 VDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINIC-WSPDGQTIAVGN 160
V + + ++ TAS DK+I++W + + + ++ + +SPDG+ I +
Sbjct: 105 VRSVDF-SADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCS 163
Query: 161 KDDVVTFIDAKTHRSKAEEQFKFEV---NEISWNNDNNMFFLTNGNGCINILSYPELKPV 217
+D + D T + F V N + +N + + + K +
Sbjct: 164 EDKTIKIWD--TTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLL 221
Query: 218 QSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHD 277
Q H CI F P G Y T S+D + + D+ E + PV T+SFS
Sbjct: 222 QHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKG 281
Query: 278 GKMLASASED 287
G++ AS D
Sbjct: 282 GELFASGGAD 291
Score = 68.2 bits (165), Expect = 1e-11
Identities = 56/242 (23%), Positives = 97/242 (40%), Gaps = 4/242 (1%)
Query: 90 VKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRT-TKCIATVNTKGENINIC 148
V E ++GH ++ L P+ L TAS D + +W+ + + V K ++
Sbjct: 9 VLERYFKGHKAAITSLDLSPNGKQL-ATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQ 67
Query: 149 WSPDGQTIAVGNKDDVVT-FIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCIN 207
+SP G +A ++D V +I K + + V + ++ D + + I
Sbjct: 68 FSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIK 127
Query: 208 ILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDW 267
+ S + + S+ H C KF P G+ + S D + +WD CV FS
Sbjct: 128 VWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVG 187
Query: 268 PVRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFT-VAWHPKRPLLAFAC 326
+ F+ G +ASA D + + +V L Q S +++HP L A
Sbjct: 188 FANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITAS 247
Query: 327 DD 328
D
Sbjct: 248 SD 249
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 89.0 bits (219), Expect = 6e-18
Identities = 80/301 (26%), Positives = 129/301 (42%), Gaps = 29/301 (9%)
Query: 54 HSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKD------RLVKENNYRGHGD------S 101
H ++V AW+ LASGS D TA ++ L ++ +LV + R G
Sbjct: 168 HESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKD 227
Query: 102 VDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNK 161
V L W+ S L T S D RIW KG + W+ G I
Sbjct: 228 VTSLDWN-SEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
Query: 162 DDVVTFIDAKTHRSKAEEQFKFE---VNEISWNNDNNMFFLTNGNGCINILSYPELKPVQ 218
D DA H +A++QF F ++ W + NN F + + CI++ + +P++
Sbjct: 287 DKTTIIWDA--HTGEAKQQFPFHSAPALDVDWQS-NNTFASCSTDMCIHVCKLGQDRPIK 343
Query: 219 SINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDG 278
+ H + IK+DP G A+ S D + +W + + CV + + T+ +S G
Sbjct: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTG 403
Query: 279 K---------MLASASEDHFIDIAEVETGDKLWEV-QCESPTFTVAWHPKRPLLAFACDD 328
MLASAS D + + +V+ G + + + + P ++VA+ P LA D
Sbjct: 404 PGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFD 463
Query: 329 K 329
K
Sbjct: 464 K 464
Score = 68.9 bits (167), Expect = 6e-12
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 11/170 (6%)
Query: 49 REFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWH 108
+ F H+ +V+++ W G LAS S D T ++ +++D V ++ + H + + W
Sbjct: 343 KTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCV--HDLQAHNKEIYTIKWS 400
Query: 109 PSNPD--------LFVTASGDKTIRIWDVRTTKCIATVNTKGENI-NICWSPDGQTIAVG 159
P+ P + +AS D T+R+WDV CI T+ E + ++ +SPDG+ +A G
Sbjct: 401 PTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASG 460
Query: 160 NKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINIL 209
+ D V + +T + + E+ WN + + +G + +L
Sbjct: 461 SFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVL 510
Score = 51.6 bits (122), Expect = 1e-06
Identities = 38/120 (31%), Positives = 68/120 (56%), Gaps = 13/120 (10%)
Query: 16 SGPGSMAPWCSVSSGPSRY--VLGMQELFRG---HSKTREFLAHSAKVHSVAWSCDGRRL 70
+GPG+ P ++ + + + + ++ RG H+ T+ H V+SVA+S DGR L
Sbjct: 402 TGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTK----HQEPVYSVAFSPDGRYL 457
Query: 71 ASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVR 130
ASGSFDK ++ + LV ++YRG G + ++CW+ + + +AS D ++ + D+R
Sbjct: 458 ASGSFDKCVHIWNTQTGALV--HSYRGTG-GIFEVCWNAAGDKVGASAS-DGSVCVLDLR 513
Score = 48.9 bits (115), Expect = 7e-06
Identities = 33/128 (25%), Positives = 56/128 (43%), Gaps = 12/128 (9%)
Query: 53 AHSAKVHSVAWSCDGR---------RLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVD 103
AH+ +++++ WS G LAS SFD T V L + DR + + H + V
Sbjct: 389 AHNKEIYTIKWSPTGPGTNNPNANLMLASASFDST--VRLWDVDRGICIHTLTKHQEPVY 446
Query: 104 QLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDD 163
+ + P L + S DK + IW+ +T + + G +CW+ G + D
Sbjct: 447 SVAFSPDGRYL-ASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDG 505
Query: 164 VVTFIDAK 171
V +D +
Sbjct: 506 SVCVLDLR 513
Score = 37.0 bits (84), Expect = 0.027
Identities = 31/124 (25%), Positives = 51/124 (41%), Gaps = 14/124 (11%)
Query: 220 INAHPSNCICIKFDPMGKYFATGSADALVSLWDVDE--------LVCVRCFSR--LDWP- 268
+ H S ++P+ A+GS D+ +W++ E LV C D P
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 269 ---VRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRPLLAFA 325
V +L ++ +G +LA+ S D F I + Q + P F + W+ K + A
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSA 284
Query: 326 CDDK 329
DK
Sbjct: 285 GVDK 288
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 89.0 bits (219), Expect = 6e-18
Identities = 76/288 (26%), Positives = 134/288 (46%), Gaps = 14/288 (4%)
Query: 52 LAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSN 111
+ H+ V SV +S +G LAS S D+ ++ + E GH + + W S+
Sbjct: 38 VGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKY--EKTLYGHNLEISDVAWS-SD 94
Query: 112 PDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINIC-WSPDGQTIAVGNKDDVVTFIDA 170
V+AS DKT+++WDVR+ KC+ T+ + C ++P I G+ D+ V +
Sbjct: 95 SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEV 154
Query: 171 KTHRS-KAEEQFKFEVNEISWNNDNNMFFLTNGNGCINI---LSYPELKPVQSINAHPSN 226
KT + K V+ + +N ++ + +G I S LK + + P +
Sbjct: 155 KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVS 214
Query: 227 CICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFS--RLDWPVRTLSFS-HDGKMLAS 283
+KF P GKY T + D + LWD C++ ++ + + +FS GK + S
Sbjct: 215 --FVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVS 272
Query: 284 ASEDHFIDIAEVETGDKLWEVQCESP-TFTVAWHPKRPLLAFACDDKD 330
SED+ + I ++T + + ++Q + + A HP L+A A + D
Sbjct: 273 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALEND 320
Score = 61.2 bits (147), Expect = 1e-09
Identities = 36/170 (21%), Positives = 79/170 (46%), Gaps = 2/170 (1%)
Query: 133 KCIATVNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTHR-SKAEEQFKFEVNEISWN 191
KC +T+ + ++ +SP+G+ +A + D ++ A + K E+++++W+
Sbjct: 34 KCTLVGHTEAVS-SVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 192 NDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLW 251
+D++ + + + + K ++++ H + C F+P +GS D V +W
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 252 DVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDKL 301
+V C++ S PV + F+ G ++ S S D I + +G L
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCL 202
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 85.9 bits (211), Expect = 5e-17
Identities = 55/205 (26%), Positives = 97/205 (47%), Gaps = 9/205 (4%)
Query: 51 FLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPS 110
F AH+A V SV + DG+ + S DKT V+ + + + + ++ +
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH-----INWVRCAKF 115
Query: 111 NPD--LFVTASGDKTIRIWDVRTTKCIATVNTKGENIN-ICWSPDGQTIAVGNKDDVVTF 167
+PD L V+AS DKT+++WD + +C+ + G + + + P G IA D+ V
Sbjct: 116 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKV 175
Query: 168 IDAKTHRSKAEEQF-KFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSN 226
D +THR Q VN +S++ N + + + IL E + + +++ H
Sbjct: 176 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGP 235
Query: 227 CICIKFDPMGKYFATGSADALVSLW 251
+ F G+YFA+G +D V +W
Sbjct: 236 ATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 58.5 bits (140), Expect = 9e-09
Identities = 46/211 (21%), Positives = 84/211 (39%), Gaps = 3/211 (1%)
Query: 121 DKTIRIWDVRT-TKCIATVNTKGENINICWSPDGQTIAVGNKDDVVT-FIDAKTHRSKAE 178
D + +W ++ ++ K + +SP G +A G++D V ++ S
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 179 EQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKY 238
V + + +D F + + + + + K + S++ H + C KF P G+
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 239 FATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETG 298
+ S D V LWD CV + V + F G +A+A D+ + + +V T
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
Query: 299 DKLWEVQCESPTFT-VAWHPKRPLLAFACDD 328
L Q S +++HP L A D
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSD 212
Score = 30.8 bits (68), Expect = 1.9
Identities = 19/85 (22%), Positives = 37/85 (43%), Gaps = 3/85 (3%)
Query: 43 RGHSKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSV 102
R H + + HSA V+ +++ G L + S D T + L + RL+ GH
Sbjct: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLL--YTLHGHQGPA 236
Query: 103 DQLCWHPSNPDLFVTASGDKTIRIW 127
+ + + + F + D+ + +W
Sbjct: 237 TTVAFSRTG-EYFASGGSDEQVMVW 260
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 85.9 bits (211), Expect = 5e-17
Identities = 55/205 (26%), Positives = 97/205 (47%), Gaps = 9/205 (4%)
Query: 51 FLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPS 110
F AH+A V SV + DG+ + S DKT V+ + + + + ++ +
Sbjct: 99 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH-----INWVRCAKF 153
Query: 111 NPD--LFVTASGDKTIRIWDVRTTKCIATVNTKGENIN-ICWSPDGQTIAVGNKDDVVTF 167
+PD L V+AS DKT+++WD + +C+ + G + + + P G IA D+ V
Sbjct: 154 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213
Query: 168 IDAKTHRSKAEEQF-KFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSN 226
D +THR Q VN +S++ N + + + IL E + + +++ H
Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGP 273
Query: 227 CICIKFDPMGKYFATGSADALVSLW 251
+ F G+YFA+G +D V +W
Sbjct: 274 ATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 73.9 bits (180), Expect = 2e-13
Identities = 73/281 (25%), Positives = 120/281 (42%), Gaps = 22/281 (7%)
Query: 46 SKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQL 105
S R F H V V +S + ++LASGS D V+ ++ + + GH D+V +
Sbjct: 10 SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQS--RAYRFTGHKDAVTCV 67
Query: 106 CWHPSNPDLFVTASGDKTIRIW--DVRTTKCIATVNTKG-ENINICWSPDGQTIAVGNKD 162
+ PS L + S DKT+RIW +V+ + +T +++ C DGQ+ + D
Sbjct: 68 NFSPSG-HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFC--SDGQSFVTASDD 124
Query: 163 DVVTFIDAKTHRSKAEEQFKFEVNE-ISW------NNDNNMFFLTNGNGCINILSYPELK 215
V THR K F F +++ I+W + D + + + + + +
Sbjct: 125 KTVKV--WATHRQK----FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178
Query: 216 PVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFS 275
V S H + F P G A D V +WDV ++ + V LSF
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238
Query: 276 HDGKMLASASEDHFIDIAEVETGDKLWEVQ-CESPTFTVAW 315
G L +AS D + I ++ G L+ + + P TVA+
Sbjct: 239 PSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF 279
Score = 30.8 bits (68), Expect = 1.9
Identities = 19/85 (22%), Positives = 37/85 (43%), Gaps = 3/85 (3%)
Query: 43 RGHSKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSV 102
R H + + HSA V+ +++ G L + S D T + L + RL+ GH
Sbjct: 217 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLL--YTLHGHQGPA 274
Query: 103 DQLCWHPSNPDLFVTASGDKTIRIW 127
+ + + + F + D+ + +W
Sbjct: 275 TTVAFSRTG-EYFASGGSDEQVMVW 298
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 85.9 bits (211), Expect = 5e-17
Identities = 55/205 (26%), Positives = 97/205 (47%), Gaps = 9/205 (4%)
Query: 51 FLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPS 110
F AH+A V SV + DG+ + S DKT V+ + + + + ++ +
Sbjct: 99 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH-----INWVRCAKF 153
Query: 111 NPD--LFVTASGDKTIRIWDVRTTKCIATVNTKGENIN-ICWSPDGQTIAVGNKDDVVTF 167
+PD L V+AS DKT+++WD + +C+ + G + + + P G IA D+ V
Sbjct: 154 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213
Query: 168 IDAKTHRSKAEEQF-KFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSN 226
D +THR Q VN +S++ N + + + IL E + + +++ H
Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGP 273
Query: 227 CICIKFDPMGKYFATGSADALVSLW 251
+ F G+YFA+G +D V +W
Sbjct: 274 ATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 73.9 bits (180), Expect = 2e-13
Identities = 73/281 (25%), Positives = 120/281 (42%), Gaps = 22/281 (7%)
Query: 46 SKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQL 105
S R F H V V +S + ++LASGS D V+ ++ + + GH D+V +
Sbjct: 10 SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQS--RAYRFTGHKDAVTCV 67
Query: 106 CWHPSNPDLFVTASGDKTIRIW--DVRTTKCIATVNTKG-ENINICWSPDGQTIAVGNKD 162
+ PS L + S DKT+RIW +V+ + +T +++ C DGQ+ + D
Sbjct: 68 NFSPSG-HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFC--SDGQSFVTASDD 124
Query: 163 DVVTFIDAKTHRSKAEEQFKFEVNE-ISW------NNDNNMFFLTNGNGCINILSYPELK 215
V THR K F F +++ I+W + D + + + + + +
Sbjct: 125 KTVKV--WATHRQK----FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178
Query: 216 PVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFS 275
V S H + F P G A D V +WDV ++ + V LSF
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238
Query: 276 HDGKMLASASEDHFIDIAEVETGDKLWEVQ-CESPTFTVAW 315
G L +AS D + I ++ G L+ + + P TVA+
Sbjct: 239 PSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF 279
Score = 30.8 bits (68), Expect = 1.9
Identities = 19/85 (22%), Positives = 37/85 (43%), Gaps = 3/85 (3%)
Query: 43 RGHSKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSV 102
R H + + HSA V+ +++ G L + S D T + L + RL+ GH
Sbjct: 217 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLL--YTLHGHQGPA 274
Query: 103 DQLCWHPSNPDLFVTASGDKTIRIW 127
+ + + + F + D+ + +W
Sbjct: 275 TTVAFSRTG-EYFASGGSDEQVMVW 298
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 85.5 bits (210), Expect = 7e-17
Identities = 99/404 (24%), Positives = 148/404 (36%), Gaps = 90/404 (22%)
Query: 5 AAAMGPSALGQSGPGSMAPWCSVSSGPSRYVLGMQELFRGHSKTREF------------- 51
AA M P+A+ Q P + +G G E+ HSK E
Sbjct: 121 AATMTPAAISQQNPPKNRE--ATVNGEEN---GAHEI-NNHSKPMEIDGDVEIPPNKATV 174
Query: 52 -LAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKD------RLVKENNYR--GH---- 98
H ++V AW+ LASGS D TA ++ L ++ +LV + R GH
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 99 GDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAV 158
V L W+ S+ L S D RIW KG + W+ G +
Sbjct: 235 NKDVTSLDWN-SDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLS 293
Query: 159 GNKDDVVTFIDAKTHRSKAEEQFKFE---VNEISWNNDNNMFFLTNGNGCINILSYPELK 215
D DA H +A++QF F ++ W N N F + + CI++
Sbjct: 294 AGVDKTTIIWDA--HTGEAKQQFPFHSAPALDVDWQN-NMTFASCSTDMCIHVCRLGCDH 350
Query: 216 PVQSINAHPSNCICIKFDPMG------------------------------------KYF 239
PV++ H + IK+DP G K+
Sbjct: 351 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWS 410
Query: 240 ATGSA---------------DALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASA 284
TG A D+ V LWDV++ VC + PV +++FS DGK LAS
Sbjct: 411 PTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 285 SEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRPLLAFACDD 328
S D ++ I ++G + Q F V W+ + + + D
Sbjct: 471 SFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASD 514
Score = 67.0 bits (162), Expect = 2e-11
Identities = 44/170 (25%), Positives = 83/170 (48%), Gaps = 11/170 (6%)
Query: 49 REFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWH 108
+ F H+ +V+++ W G LAS S D T ++ +++D V ++ + H + + W
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACV--HDLQAHSKEIYTIKWS 410
Query: 109 P-----SNPD---LFVTASGDKTIRIWDVRTTKCIATVNTKGENI-NICWSPDGQTIAVG 159
P SNP+ + +AS D T+R+WDV C T+ E + ++ +SPDG+ +A G
Sbjct: 411 PTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 160 NKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINIL 209
+ D V + ++ Q + E+ WN + + +G + +L
Sbjct: 471 SFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVL 520
Score = 47.0 bits (110), Expect = 3e-05
Identities = 31/126 (24%), Positives = 55/126 (43%), Gaps = 12/126 (9%)
Query: 53 AHSAKVHSVAWSCDGRR---------LASGSFDKTASVFLLEKDRLVKENNYRGHGDSVD 103
AHS +++++ WS G LAS SFD T ++ +E+ V + H + V
Sbjct: 399 AHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVY 456
Query: 104 QLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDD 163
+ + P L + S DK + IW+ ++ + + G +CW+ G + D
Sbjct: 457 SVAFSPDGKYL-ASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDG 515
Query: 164 VVTFID 169
V +D
Sbjct: 516 SVCVLD 521
Score = 47.0 bits (110), Expect = 3e-05
Identities = 28/82 (34%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 48 TREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCW 107
T + H V+SVA+S DG+ LASGSFDK ++ + LV ++Y+G G + ++CW
Sbjct: 445 THTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLV--HSYQGTG-GIFEVCW 501
Query: 108 HPSNPDLFVTASGDKTIRIWDV 129
+ + +AS D ++ + D+
Sbjct: 502 NARGDKVGASAS-DGSVCVLDL 522
Score = 37.0 bits (84), Expect = 0.027
Identities = 34/125 (27%), Positives = 54/125 (43%), Gaps = 16/125 (12%)
Query: 220 INAHPSNCICIKFDPMGKYFATGSADALVSLWDVDE--------LVCVRCFSR--LDWP- 268
+ H S ++P+ A+GS D+ +W+++E LV C D P
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 269 ---VRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEV-QCESPTFTVAWHPKRPLLAF 324
V +L ++ DG +LA S D F I E G+ + Q + P F + W+ K +
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARI-WTENGNLASTLGQHKGPIFALKWNKKGNYVLS 293
Query: 325 ACDDK 329
A DK
Sbjct: 294 AGVDK 298
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 85.5 bits (210), Expect = 7e-17
Identities = 99/404 (24%), Positives = 148/404 (36%), Gaps = 90/404 (22%)
Query: 5 AAAMGPSALGQSGPGSMAPWCSVSSGPSRYVLGMQELFRGHSKTREF------------- 51
AA M P+A+ Q P + +G G E+ HSK E
Sbjct: 121 AATMTPAAISQQNPPKNRE--ATVNGEEN---GAHEI-NNHSKPMEIDGDVEIPPNKATV 174
Query: 52 -LAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKD------RLVKENNYR--GH---- 98
H ++V AW+ LASGS D TA ++ L ++ +LV + R GH
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 99 GDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAV 158
V L W+ S+ L S D RIW KG + W+ G +
Sbjct: 235 NKDVTSLDWN-SDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLS 293
Query: 159 GNKDDVVTFIDAKTHRSKAEEQFKFE---VNEISWNNDNNMFFLTNGNGCINILSYPELK 215
D DA H +A++QF F ++ W N N F + + CI++
Sbjct: 294 AGVDKTTIIWDA--HTGEAKQQFPFHSAPALDVDWQN-NMTFASCSTDMCIHVCRLGCDH 350
Query: 216 PVQSINAHPSNCICIKFDPMG------------------------------------KYF 239
PV++ H + IK+DP G K+
Sbjct: 351 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWS 410
Query: 240 ATGSA---------------DALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASA 284
TG A D+ V LWDV++ VC + PV +++FS DGK LAS
Sbjct: 411 PTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 285 SEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRPLLAFACDD 328
S D ++ I ++G + Q F V W+ + + + D
Sbjct: 471 SFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASD 514
Score = 67.0 bits (162), Expect = 2e-11
Identities = 44/170 (25%), Positives = 83/170 (48%), Gaps = 11/170 (6%)
Query: 49 REFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWH 108
+ F H+ +V+++ W G LAS S D T ++ +++D V ++ + H + + W
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACV--HDLQAHSKEIYTIKWS 410
Query: 109 P-----SNPD---LFVTASGDKTIRIWDVRTTKCIATVNTKGENI-NICWSPDGQTIAVG 159
P SNP+ + +AS D T+R+WDV C T+ E + ++ +SPDG+ +A G
Sbjct: 411 PTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 160 NKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINIL 209
+ D V + ++ Q + E+ WN + + +G + +L
Sbjct: 471 SFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVL 520
Score = 47.0 bits (110), Expect = 3e-05
Identities = 31/126 (24%), Positives = 55/126 (43%), Gaps = 12/126 (9%)
Query: 53 AHSAKVHSVAWSCDGRR---------LASGSFDKTASVFLLEKDRLVKENNYRGHGDSVD 103
AHS +++++ WS G LAS SFD T ++ +E+ V + H + V
Sbjct: 399 AHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVY 456
Query: 104 QLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDD 163
+ + P L + S DK + IW+ ++ + + G +CW+ G + D
Sbjct: 457 SVAFSPDGKYL-ASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDG 515
Query: 164 VVTFID 169
V +D
Sbjct: 516 SVCVLD 521
Score = 47.0 bits (110), Expect = 3e-05
Identities = 28/82 (34%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 48 TREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCW 107
T + H V+SVA+S DG+ LASGSFDK ++ + LV ++Y+G G + ++CW
Sbjct: 445 THTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLV--HSYQGTG-GIFEVCW 501
Query: 108 HPSNPDLFVTASGDKTIRIWDV 129
+ + +AS D ++ + D+
Sbjct: 502 NARGDKVGASAS-DGSVCVLDL 522
Score = 37.0 bits (84), Expect = 0.027
Identities = 34/125 (27%), Positives = 54/125 (43%), Gaps = 16/125 (12%)
Query: 220 INAHPSNCICIKFDPMGKYFATGSADALVSLWDVDE--------LVCVRCFSR--LDWP- 268
+ H S ++P+ A+GS D+ +W+++E LV C D P
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 269 ---VRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEV-QCESPTFTVAWHPKRPLLAF 324
V +L ++ DG +LA S D F I E G+ + Q + P F + W+ K +
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARI-WTENGNLASTLGQHKGPIFALKWNKKGNYVLS 293
Query: 325 ACDDK 329
A DK
Sbjct: 294 AGVDK 298
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 85.5 bits (210), Expect = 7e-17
Identities = 99/404 (24%), Positives = 148/404 (36%), Gaps = 90/404 (22%)
Query: 5 AAAMGPSALGQSGPGSMAPWCSVSSGPSRYVLGMQELFRGHSKTREF------------- 51
AA M P+A+ Q P + +G G E+ HSK E
Sbjct: 121 AATMTPAAISQQNPPKNRE--ATVNGEEN---GAHEI-NNHSKPMEIDGDVEIPPNKATV 174
Query: 52 -LAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKD------RLVKENNYR--GH---- 98
H ++V AW+ LASGS D TA ++ L ++ +LV + R GH
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 99 GDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAV 158
V L W+ S+ L S D RIW KG + W+ G +
Sbjct: 235 NKDVTSLDWN-SDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLS 293
Query: 159 GNKDDVVTFIDAKTHRSKAEEQFKFE---VNEISWNNDNNMFFLTNGNGCINILSYPELK 215
D DA H +A++QF F ++ W N N F + + CI++
Sbjct: 294 AGVDKTTIIWDA--HTGEAKQQFPFHSAPALDVDWQN-NMTFASCSTDMCIHVCRLGCDH 350
Query: 216 PVQSINAHPSNCICIKFDPMG------------------------------------KYF 239
PV++ H + IK+DP G K+
Sbjct: 351 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWS 410
Query: 240 ATGSA---------------DALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASA 284
TG A D+ V LWDV++ VC + PV +++FS DGK LAS
Sbjct: 411 PTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 285 SEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRPLLAFACDD 328
S D ++ I ++G + Q F V W+ + + + D
Sbjct: 471 SFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASD 514
Score = 67.0 bits (162), Expect = 2e-11
Identities = 44/170 (25%), Positives = 83/170 (48%), Gaps = 11/170 (6%)
Query: 49 REFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWH 108
+ F H+ +V+++ W G LAS S D T ++ +++D V ++ + H + + W
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACV--HDLQAHSKEIYTIKWS 410
Query: 109 P-----SNPD---LFVTASGDKTIRIWDVRTTKCIATVNTKGENI-NICWSPDGQTIAVG 159
P SNP+ + +AS D T+R+WDV C T+ E + ++ +SPDG+ +A G
Sbjct: 411 PTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 160 NKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINIL 209
+ D V + ++ Q + E+ WN + + +G + +L
Sbjct: 471 SFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVL 520
Score = 47.0 bits (110), Expect = 3e-05
Identities = 31/126 (24%), Positives = 55/126 (43%), Gaps = 12/126 (9%)
Query: 53 AHSAKVHSVAWSCDGRR---------LASGSFDKTASVFLLEKDRLVKENNYRGHGDSVD 103
AHS +++++ WS G LAS SFD T ++ +E+ V + H + V
Sbjct: 399 AHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVY 456
Query: 104 QLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDD 163
+ + P L + S DK + IW+ ++ + + G +CW+ G + D
Sbjct: 457 SVAFSPDGKYL-ASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDG 515
Query: 164 VVTFID 169
V +D
Sbjct: 516 SVCVLD 521
Score = 47.0 bits (110), Expect = 3e-05
Identities = 28/82 (34%), Positives = 48/82 (58%), Gaps = 4/82 (4%)
Query: 48 TREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCW 107
T + H V+SVA+S DG+ LASGSFDK ++ + LV ++Y+G G + ++CW
Sbjct: 445 THTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLV--HSYQGTG-GIFEVCW 501
Query: 108 HPSNPDLFVTASGDKTIRIWDV 129
+ + +AS D ++ + D+
Sbjct: 502 NARGDKVGASAS-DGSVCVLDL 522
Score = 37.0 bits (84), Expect = 0.027
Identities = 34/125 (27%), Positives = 54/125 (43%), Gaps = 16/125 (12%)
Query: 220 INAHPSNCICIKFDPMGKYFATGSADALVSLWDVDE--------LVCVRCFSR--LDWP- 268
+ H S ++P+ A+GS D+ +W+++E LV C D P
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 269 ---VRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEV-QCESPTFTVAWHPKRPLLAF 324
V +L ++ DG +LA S D F I E G+ + Q + P F + W+ K +
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARI-WTENGNLASTLGQHKGPIFALKWNKKGNYVLS 293
Query: 325 ACDDK 329
A DK
Sbjct: 294 AGVDK 298
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 84.3 bits (207), Expect = 1e-16
Identities = 76/334 (22%), Positives = 140/334 (41%), Gaps = 39/334 (11%)
Query: 10 PSALGQSGPGSMAPWCSVSSGPSRYVLGMQELFRGHSKTREFLAHSAKVHSVAWSCDGRR 69
P AL Q+GP P CS P + G H +V+ + +G
Sbjct: 41 PGALLQAGP----PRCSSLQAPIMLLSG----------------HEGEVYCCKFHPNGST 80
Query: 70 LASGSFDKTASVFLLEKDRLVKENNY---RGHGDSVDQLCWHPSNPDLFVTASGDKTIRI 126
LAS FD+ ++ + D +NY +GH +V +L ++ LF +AS DKT+ +
Sbjct: 81 LASAGFDRLILLWNVYGDC----DNYATLKGHSGAVMELHYNTDGSMLF-SASTDKTVAV 135
Query: 127 WDVRTTKCIATVNTKGENINICWSP--DGQTIAVGNKDDVVTFIDAKTHRSKAEEQFKFE 184
WD T + + + +N C+ Q + G+ D V D + + Q ++
Sbjct: 136 WDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ 195
Query: 185 VNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSA 244
V +++N+ ++ + I + + K ++ H + + G Y + +
Sbjct: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
Query: 245 DALVSLWDVDELV----CVRCFS----RLDWPVRTLSFSHDGKMLASASEDHFIDIAEVE 296
D V +WDV CV+ F + + S+S DG +A+ S D F+ + +
Sbjct: 256 DNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTT 315
Query: 297 TGDKLWEVQCESPTFT-VAWHPKRPLLAFACDDK 329
+ L+++ + + VA+HP P++ A DK
Sbjct: 316 SRRILYKLPGHAGSINEVAFHPDEPIIISASSDK 349
Score = 52.0 bits (123), Expect = 8e-07
Identities = 38/136 (27%), Positives = 61/136 (44%), Gaps = 16/136 (11%)
Query: 216 PVQSINAHPSNCICIKFDPMGKYFATGSADALVSLW----DVDELVCVRCFSRLDWPVRT 271
P+ ++ H C KF P G A+ D L+ LW D D ++ S V
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHS---GAVME 114
Query: 272 LSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRPLLAFACDDKDG 331
L ++ DG ML SAS D + + + ETG+++ ++ + +F + +P R C D
Sbjct: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHT-SFVNSCYPARRGPQLVCTGSDD 173
Query: 332 KYDSSREAGTVKLFGL 347
GTVKL+ +
Sbjct: 174 --------GTVKLWDI 181
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 79.3 bits (194), Expect = 5e-15
Identities = 63/251 (25%), Positives = 114/251 (45%), Gaps = 6/251 (2%)
Query: 54 HSAKVHSVAWSCD-GRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNP 112
H V+++A++ G ++A+GSFDKT ++ +E + + +RGH + L ++P +
Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCY--HTFRGHTAEIVCLSFNPQST 190
Query: 113 DLFVTASGDKTIRIWDVRTTKCIATVNT-KGENINICWSPDGQTIAVGNKDDVVTFIDAK 171
L T S D T ++WD++ + + T+ E I++ ++ G I G+ D V DA
Sbjct: 191 -LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDAD 249
Query: 172 THRS-KAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICI 230
T R E++ S+N D ++ + + + K V ++ H +
Sbjct: 250 TGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDS 309
Query: 231 KFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFI 290
FD GK AT SAD ++ C+ + + +SF+ G L + S D
Sbjct: 310 CFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTA 369
Query: 291 DIAEVETGDKL 301
I + +TG L
Sbjct: 370 RIWDAQTGQCL 380
Score = 77.0 bits (188), Expect = 2e-14
Identities = 54/200 (27%), Positives = 92/200 (46%), Gaps = 5/200 (2%)
Query: 54 HSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPD 113
HSA++ S++++ G R+ +GSFD T V+ + R K N GH + ++ +
Sbjct: 218 HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR--KVNILIGHCAEISSASFN-WDCS 274
Query: 114 LFVTASGDKTIRIWDVRTTKCIATVNTKGENI-NICWSPDGQTIAVGNKDDVVTFIDAKT 172
L +T S DKT ++WD KC+AT+ + I + C+ G+ IA + D A T
Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAAT 334
Query: 173 HRSKAE-EQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIK 231
+ A+ E + E+++IS+N N + + I + +Q + H
Sbjct: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCA 394
Query: 232 FDPMGKYFATGSADALVSLW 251
F+ G TGS D +W
Sbjct: 395 FNYKGNIVITGSKDNTCRIW 414
Score = 68.9 bits (167), Expect = 6e-12
Identities = 56/241 (23%), Positives = 97/241 (40%), Gaps = 12/241 (4%)
Query: 53 AHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNP 112
AH + +VA + G +GS+D+T ++ + N GH + V + ++
Sbjct: 90 AHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEEL--NTLEGHRNVVYAIAFNNPYG 147
Query: 113 DLFVTASGDKTIRIWDVRTTKCIATV-NTKGENINICWSPDGQTIAVGNKDDVVTFIDAK 171
D T S DKT ++W V T KC T E + + ++P +A G+ D D +
Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
Query: 172 THRSKAEEQFKF-----EVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSN 226
EE + E+ +S+N + + + + + + V + H +
Sbjct: 208 ----NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263
Query: 227 CICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASE 286
F+ TGS D LWD CV + D + F + GK++A+AS
Sbjct: 264 ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASA 323
Query: 287 D 287
D
Sbjct: 324 D 324
Score = 58.2 bits (139), Expect = 1e-08
Identities = 38/127 (29%), Positives = 60/127 (47%), Gaps = 4/127 (3%)
Query: 47 KTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLC 106
K + H A++ S +++ D + +GS DKT ++ + V GH D + C
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVA--TLTGHDDEILDSC 310
Query: 107 WHPSNPDLFVTASGDKTIRIWDVRTTKCIATV-NTKGENINICWSPDGQTIAVGNKDDVV 165
+ + L TAS D T RI+ T KCIA + +GE I ++P G + G+ D
Sbjct: 311 FDYTG-KLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTA 369
Query: 166 TFIDAKT 172
DA+T
Sbjct: 370 RIWDAQT 376
Score = 41.2 bits (95), Expect = 0.001
Identities = 28/101 (27%), Positives = 43/101 (42%), Gaps = 10/101 (9%)
Query: 217 VQSINAHPSNCICIKFD-PMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFS 275
+ ++ H + I F+ P G ATGS D LW V+ C F + LSF+
Sbjct: 127 LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFN 186
Query: 276 HDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFTVAWH 316
++A+ S D T KLW++Q +T+ H
Sbjct: 187 PQSTLVATGSMD---------TTAKLWDIQNGEEVYTLRGH 218
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 76.3 bits (186), Expect = 4e-14
Identities = 61/249 (24%), Positives = 108/249 (43%), Gaps = 16/249 (6%)
Query: 47 KTREFLAHSAKVHS-VAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQL 105
K +E +AH++ V S V GR LA+G D +++ + K + + GH V+ +
Sbjct: 12 KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIM--SLTGHTSPVESV 69
Query: 106 CWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINIC---WSPDGQTIAVGNKD 162
+ +L V S +IR+WD+ K + T+ G NIC + P G+ +A G++D
Sbjct: 70 RLNTPE-ELIVAGSQSGSIRVWDLEAAKILRTL--MGHKANICSLDFHPYGEFVASGSQD 126
Query: 163 DVVTFIDAK----THRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQ 218
+ D + R + Q V + ++ D + + + K +
Sbjct: 127 TNIKLWDIRRKGCVFRYRGHSQ---AVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS 183
Query: 219 SINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDG 278
H ++F P A+GS+D + WD+++ V C PVR++ F+ DG
Sbjct: 184 EFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDG 243
Query: 279 KMLASASED 287
L S +D
Sbjct: 244 CCLYSGCQD 252
Score = 76.3 bits (186), Expect = 4e-14
Identities = 43/146 (29%), Positives = 70/146 (47%), Gaps = 1/146 (0%)
Query: 185 VNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSA 244
V + N + + +G I + K ++++ H +N + F P G++ A+GS
Sbjct: 66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQ 125
Query: 245 DALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEV 304
D + LWD+ CV + VR L FS DGK LASA++DH + + ++ G + E
Sbjct: 126 DTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF 185
Query: 305 QCES-PTFTVAWHPKRPLLAFACDDK 329
+ P V +HP LLA D+
Sbjct: 186 PGHTGPVNVVEFHPNEYLLASGSSDR 211
Score = 38.1 bits (87), Expect = 0.012
Identities = 29/128 (22%), Positives = 55/128 (42%), Gaps = 2/128 (1%)
Query: 217 VQSINAHPSNCICIKFDPM-GKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFS 275
+Q I AH SN + G+ ATG D V+LW +++ C+ + PV ++ +
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
Query: 276 HDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTF-TVAWHPKRPLLAFACDDKDGKYD 334
+++ + S+ I + ++E L + ++ +HP +A D + K
Sbjct: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
Query: 335 SSREAGTV 342
R G V
Sbjct: 133 DIRRKGCV 140
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 72.8 bits (177), Expect = 4e-13
Identities = 52/205 (25%), Positives = 90/205 (43%), Gaps = 3/205 (1%)
Query: 97 GHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINIC-WSPDGQT 155
GH D + C+HPS D T+SGD T+++WD+ CI T + C W G
Sbjct: 392 GHTDWLSDCCFHPSG-DKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNF 450
Query: 156 IAVGNKDDVVTFIDAKTHRSKAEEQFKFE-VNEISWNNDNNMFFLTNGNGCINILSYPEL 214
+A + D D + R + + VN I + +N ++ + ++I
Sbjct: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510
Query: 215 KPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSF 274
QS+ H + FDP G A+ A + LWD +L+ + P ++F
Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNF 570
Query: 275 SHDGKMLASASEDHFIDIAEVETGD 299
G++LA AS + I + ++++G+
Sbjct: 571 DSSGRVLAQASGNGVIHLLDLKSGE 595
Score = 72.8 bits (177), Expect = 4e-13
Identities = 57/223 (25%), Positives = 103/223 (46%), Gaps = 6/223 (2%)
Query: 67 GRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRI 126
G +LA+ S D T ++ L K + + GH +V WH S + ++S DKT +I
Sbjct: 406 GDKLATSSGDTTVKLWDLCKGDCIL--TFEGHSRAVWSCTWH-SCGNFVASSSLDKTSKI 462
Query: 127 WDVRTTKCIATVNTKGENIN-ICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQ-FKFE 184
WDV + +C T+ +++N I + P T+ + D ++ DA+T +
Sbjct: 463 WDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHS 522
Query: 185 VNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSA 244
+N+ ++ +M + G + + +L P+ SI+ PS + FD G+ A S
Sbjct: 523 INDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASG 582
Query: 245 DALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASED 287
+ ++ L D+ + + T+ FSHDG++L S D
Sbjct: 583 NGVIHLLDLKSGEIHKLMGHEN-EAHTVVFSHDGEILFSGGSD 624
Score = 68.9 bits (167), Expect = 6e-12
Identities = 55/207 (26%), Positives = 93/207 (44%), Gaps = 14/207 (6%)
Query: 51 FLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPS 110
F HS V S W G +AS S DKT+ ++ + +R GH DSV+ + + P
Sbjct: 432 FEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC--RCTLYGHTDSVNSIEFFPF 489
Query: 111 NPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENIN-ICWSPDGQTIAVGNKDDVVTFID 169
+ L +T+S DKT+ IWD RT C ++ +IN + P G IA + V D
Sbjct: 490 SNTL-LTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548
Query: 170 AKTHRSKAEEQFKFEV-----NEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHP 224
+ K ++ NE+++++ + +GNG I++L + + + H
Sbjct: 549 FR----KLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDL-KSGEIHKLMGHE 603
Query: 225 SNCICIKFDPMGKYFATGSADALVSLW 251
+ + F G+ +G +D V W
Sbjct: 604 NEAHTVVFSHDGEILFSGGSDGTVRTW 630
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 72.8 bits (177), Expect = 4e-13
Identities = 70/298 (23%), Positives = 125/298 (41%), Gaps = 57/298 (19%)
Query: 53 AHSAKVHSVAWSCDGRR----LASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWH 108
AH + SVAW + + + +GS D V+ +RL + + GH V +
Sbjct: 14 AHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDIS 73
Query: 109 PSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENI-NICWSPDGQTIAVGNKDDVVTF 167
+ P + ++S D IR+WD+ K I +++ + + +SPD Q +A G
Sbjct: 74 HTLP-IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATG-------- 124
Query: 168 IDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNC 227
TH K +NI K S++
Sbjct: 125 ----THVGK-----------------------------VNIFGVESGKKEYSLDTRGKFI 151
Query: 228 ICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASED 287
+ I + P GKY A+G+ D +++++D+ + P+R+L+FS D ++L +AS+D
Sbjct: 152 LSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDD 211
Query: 288 HFIDIAEVETGDKLWEVQCESPTFTVAWHPKRPLLAFACDDKDGKYDSSREAGTVKLF 345
+I K+++VQ + T++ H L C D D + SS +VK++
Sbjct: 212 GYI---------KIYDVQHANLAGTLSGHASWVLNVAFCPD-DTHFVSSSSDKSVKVW 259
Score = 51.6 bits (122), Expect = 1e-06
Identities = 43/162 (26%), Positives = 74/162 (45%), Gaps = 11/162 (6%)
Query: 19 GSMAPWCSVSSGPSRYV-----LGMQELFRGHSKTREFLAHSAK--VHSVAWSCDGRRLA 71
G + W S S+Y+ +G +F S +E+ + + S+A+S DG+ LA
Sbjct: 105 GPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLA 164
Query: 72 SGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRT 131
SG+ D ++F + +L+ + GH + L + P + L VTAS D I+I+DV+
Sbjct: 165 SGAIDGIINIFDIATGKLL--HTLEGHAMPIRSLTFSPDS-QLLVTASDDGYIKIYDVQH 221
Query: 132 TKCIATVNTKGE-NINICWSPDGQTIAVGNKDDVVTFIDAKT 172
T++ +N+ + PD + D V D T
Sbjct: 222 ANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGT 263
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 72.0 bits (175), Expect = 7e-13
Identities = 61/258 (23%), Positives = 116/258 (44%), Gaps = 11/258 (4%)
Query: 47 KTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLC 106
+ + F H +V+S A+S DG+ L +GS D + +L+ GH V + C
Sbjct: 13 RVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG--GHTGPV-KFC 69
Query: 107 WHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENI-NICWSPDGQTIAVGNKDDVV 165
+ LF +AS D T+R+WDV KC+ + ++ + +SPD + +A G D V
Sbjct: 70 RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129
Query: 166 TFIDAKTHRS-KAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPV---QSIN 221
D ++ + + + + ++ N + + ++I + P Q++
Sbjct: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE 189
Query: 222 AHPSNCICIKFDPMGKYFATGSADALVSLW-DVDELVCVRCFSRLDWPVRTLSFSHDGKM 280
H +N C+ + G A+GS D + +W + ++ + W V++++FS D
Sbjct: 190 GHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTW-VKSIAFSPDELW 247
Query: 281 LASASEDHFIDIAEVETG 298
LASA + + + TG
Sbjct: 248 LASAGYSRMVKVWDCNTG 265
Score = 59.3 bits (142), Expect = 5e-09
Identities = 35/118 (29%), Positives = 54/118 (45%)
Query: 184 EVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGS 243
EVN +++ D M + +GC+ + + + H +F P G FA+ S
Sbjct: 23 EVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASAS 82
Query: 244 ADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDKL 301
D V LWDV C+R V T+SFS D + LAS D + + +V++G L
Sbjct: 83 CDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQML 140
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/129 (27%), Positives = 68/129 (52%), Gaps = 8/129 (6%)
Query: 54 HSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPD 113
HSA + + +S G LASGS+DKT ++ L+ + +GH V + + P +
Sbjct: 191 HSANISCLCYSASGL-LASGSWDKTIHIWKPTTSSLLIQ--LKGHVTWVKSIAFSPD--E 245
Query: 114 LFVTASG-DKTIRIWDVRTTKCIATVNTKGENINIC-WSPDGQTIAVGNKDDVVTFIDAK 171
L++ ++G + +++WD T KC+ T+ + + C ++PDG+ + G D I ++
Sbjct: 246 LWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQI-SR 304
Query: 172 THRSKAEEQ 180
T +S + Q
Sbjct: 305 TSKSPRDPQ 313
Score = 32.7 bits (73), Expect = 0.50
Identities = 23/82 (28%), Positives = 34/82 (41%)
Query: 214 LKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLS 273
++ V+ H F P G+ TGS D V W+ + PV+
Sbjct: 11 VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCR 70
Query: 274 FSHDGKMLASASEDHFIDIAEV 295
FS DG + ASAS D + + +V
Sbjct: 71 FSPDGHLFASASCDCTVRLWDV 92
Score = 30.8 bits (68), Expect = 1.9
Identities = 16/46 (34%), Positives = 25/46 (54%)
Query: 259 VRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEV 304
V+ F + V + +FS DG+ML + SED + E +G LW +
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL 59
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 71.6 bits (174), Expect = 1e-12
Identities = 63/241 (26%), Positives = 102/241 (42%), Gaps = 27/241 (11%)
Query: 49 REFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWH 108
R H+ V +++ G+ LAS S D T ++ + ++ GH +V +
Sbjct: 144 RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIR--TMHGHDHNVSSVAIM 201
Query: 109 PSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICW-SPDGQTIAVGNKDDVVTF 167
P N D V+AS DKTI++W+V+T C+ T E + + + DG IA + D V
Sbjct: 202 P-NGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRV 260
Query: 168 IDAKTHRSKAE-EQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSN 226
T KAE + + V ISW +++ ++ G E K
Sbjct: 261 WVVATKECKAELREHEHVVECISWAPESSYSSISEATG-------SETK----------- 302
Query: 227 CICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASE 286
K G + +GS D + +WDV +C+ D VR + F GK + S ++
Sbjct: 303 ----KSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCAD 358
Query: 287 D 287
D
Sbjct: 359 D 359
Score = 56.2 bits (134), Expect = 4e-08
Identities = 50/233 (21%), Positives = 90/233 (38%), Gaps = 25/233 (10%)
Query: 42 FRGHSKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDS 101
F+G R H V SVA +G + S S DKT ++ ++ VK + GH +
Sbjct: 179 FQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK--TFTGHREW 236
Query: 102 VDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENIN-ICWSPD-------- 152
V ++ + L + S D+T+R+W V T +C A + + I W+P+
Sbjct: 237 V-RMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 153 ------------GQTIAVGNKDDVVTFIDAKTHRS-KAEEQFKFEVNEISWNNDNNMFFL 199
G + G++D + D T V + +++
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILS 355
Query: 200 TNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWD 252
+ + + Y + ++++NAH + F Y TGS D V +W+
Sbjct: 356 CADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 55.8 bits (133), Expect = 6e-08
Identities = 47/224 (20%), Positives = 92/224 (41%), Gaps = 44/224 (19%)
Query: 97 GHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTI 156
GH V ++ +HP + V+AS D TI++WD T D +
Sbjct: 106 GHRSPVTRVIFHPVF-SVMVSASEDATIKVWDYET-------------------GDFERT 145
Query: 157 AVGNKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKP 216
G+ D V +IS+++ + + + I + + +
Sbjct: 146 LKGHTD---------------------SVQDISFDHSGKLLASCSADMTIKLWDFQGFEC 184
Query: 217 VQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFS-RLDWPVRTLSFS 275
+++++ H N + P G + + S D + +W+V CV+ F+ +W VR + +
Sbjct: 185 IRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREW-VRMVRPN 243
Query: 276 HDGKMLASASEDHFIDIAEVETGDKLWEV-QCESPTFTVAWHPK 318
DG ++AS S D + + V T + E+ + E ++W P+
Sbjct: 244 QDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPE 287
Score = 41.6 bits (96), Expect = 0.001
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 9/87 (10%)
Query: 219 SINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDG 278
+++ H S + F P+ + S DA + +WD + R V+ +SF H G
Sbjct: 103 ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162
Query: 279 KMLASASEDHFIDIAEVETGDKLWEVQ 305
K+LAS S D I KLW+ Q
Sbjct: 163 KLLASCSADMTI---------KLWDFQ 180
Score = 35.8 bits (81), Expect = 0.059
Identities = 24/79 (30%), Positives = 40/79 (50%), Gaps = 3/79 (3%)
Query: 52 LAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSN 111
+ H V V + G+ + S + DKT V+ + R +K N H V L +H +
Sbjct: 335 VGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLN--AHEHFVTSLDFHKTA 392
Query: 112 PDLFVTASGDKTIRIWDVR 130
P + VT S D+T+++W+ R
Sbjct: 393 PYV-VTGSVDQTVKVWECR 410
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 71.6 bits (174), Expect = 1e-12
Identities = 76/314 (24%), Positives = 121/314 (38%), Gaps = 81/314 (25%)
Query: 54 HSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPD 113
H V VAWS G LAS SFD T ++ +D GH + V + W PS +
Sbjct: 60 HQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSG-N 118
Query: 114 LFVTASGDKTIRIWDVRTT---KCIATVNTKGENI-NICWSPDGQTIAVGNKDDVVTFID 169
L T S DK++ +W+V +C++ +N+ +++ ++ W P + +A + DD V
Sbjct: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTV---- 174
Query: 170 AKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCIC 229
K +R + ++ C ++ H S
Sbjct: 175 -KLYREEEDDWV-----------------------CC-----------ATLEGHESTVWS 199
Query: 230 IKFDPMGKYFATGSADALVSLW----DVDELVCVRCFSRLDWP-VRTLSFSHDGKM---- 280
+ FDP G+ A+ S D V +W +E S W + TLS H +
Sbjct: 200 LAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIA 259
Query: 281 -------LASASEDHFIDIAEVETGDKLWEVQCESPTFT---------------VAWHPK 318
LA+A D I + + + + PTF+ VAW+PK
Sbjct: 260 WCQLTGALATACGDDAIRVFQEDPNS-----DPQQPTFSLTAHLHQAHSQDVNCVAWNPK 314
Query: 319 RPLLAFACDDKDGK 332
P L +C D DG+
Sbjct: 315 EPGLLASCSD-DGE 327
Score = 58.5 bits (140), Expect = 9e-09
Identities = 67/275 (24%), Positives = 107/275 (38%), Gaps = 35/275 (12%)
Query: 86 KDRLVKENNYRGHGDSVDQ-LCWHPSNPDLFVTASGDKTIRIWDVRTTKCIA-TVNTKGE 143
KD LV H DS L W+P+ L + GD+ IRIW I +V ++G
Sbjct: 2 KDSLVLLGRVPAHPDSRCWFLAWNPAGT-LLASCGGDRRIRIWGTEGDSWICKSVLSEGH 60
Query: 144 NINI---CWSPDGQTIAVGNKDDVVTFIDAKTHRSKAE-----EQFKFEVNEISWNNDNN 195
+ WSP G +A + D T K ++ E E + EV ++W N
Sbjct: 61 QRTVRKVAWSPCGNYLASASFD--ATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN 118
Query: 196 MFFLTNGNGCI---NILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLW- 251
+ + + + + E + V +N+H + + + P + A+ S D V L+
Sbjct: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178
Query: 252 -DVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDI-----------AEVETGD 299
+ D+ VC + V +L+F G+ LAS S+D + I D
Sbjct: 179 EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSD 238
Query: 300 KLWEVQC------ESPTFTVAWHPKRPLLAFACDD 328
W+ C + +AW LA AC D
Sbjct: 239 PSWKCICTLSGFHSRTIYDIAWCQLTGALATACGD 273
Score = 45.1 bits (105), Expect = 1e-04
Identities = 40/166 (24%), Positives = 62/166 (37%), Gaps = 28/166 (16%)
Query: 53 AHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNP 112
+H+ V V W LAS S+D T ++ E+D V GH +V L + PS
Sbjct: 148 SHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQ 207
Query: 113 DLFVTASGDKTIRIW---------------DVRTTKCIATVNTKGEN--INICWSPDGQT 155
L + S D+T+RIW + KCI T++ +I W
Sbjct: 208 RL-ASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGA 266
Query: 156 IAVGNKDDVVTFIDAKTHRSKAEEQFKF----------EVNEISWN 191
+A DD + + + F +VN ++WN
Sbjct: 267 LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWN 312
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 71.2 bits (173), Expect = 1e-12
Identities = 59/241 (24%), Positives = 97/241 (40%), Gaps = 52/241 (21%)
Query: 66 DGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIR 125
D ++ +G DK VF ++++ +GH V + +HPS DL +AS D TIR
Sbjct: 233 DTNKILTGGADKNVVVFDKSSEQILA--TLKGHTKKVTSVVFHPSQ-DLVFSASPDATIR 289
Query: 126 IWDVRTTKCIATVNTKGENIN-ICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQFKFE 184
IW V C+ V + + G + + D F D +T R +
Sbjct: 290 IWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKV----- 344
Query: 185 VNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSA 244
+E S GC + C +F P G F TG+
Sbjct: 345 TDETS--------------GC--------------------SLTCAQFHPDGLIFGTGTM 370
Query: 245 DALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEV 304
D+ + +WD+ E V F P+ +++FS +G LA+A++D + KLW++
Sbjct: 371 DSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSV---------KLWDL 421
Query: 305 Q 305
+
Sbjct: 422 R 422
Score = 41.6 bits (96), Expect = 0.001
Identities = 23/90 (25%), Positives = 40/90 (44%)
Query: 219 SINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDG 278
++ H + F P + S DA + +W V CV+ + V LS G
Sbjct: 259 TLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATG 318
Query: 279 KMLASASEDHFIDIAEVETGDKLWEVQCES 308
L S+S+D + ++++TG L +V E+
Sbjct: 319 DYLLSSSDDQYWAFSDIQTGRVLTKVTDET 348
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 67.8 bits (164), Expect = 1e-11
Identities = 55/217 (25%), Positives = 90/217 (41%), Gaps = 47/217 (21%)
Query: 97 GHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINIC---WSPDG 153
GH V + P + +++S D T+R+W ++T C+ V KG N + +SP G
Sbjct: 541 GHSGPVYGASFSPDR-NYLLSSSEDGTVRLWSLQTFTCL--VGYKGHNYPVWDTQFSPYG 597
Query: 154 QTIAVGNKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPE 213
G D V W D+
Sbjct: 598 YYFVSGGHDRVARL----------------------WATDH------------------- 616
Query: 214 LKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLS 273
+P++ H ++ C +F P Y ATGSAD V LWDV CVR F+ P+ +L+
Sbjct: 617 YQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLT 676
Query: 274 FSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPT 310
FS +G+ LA+ + D + + ++ G + E++ + T
Sbjct: 677 FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDT 713
Score = 52.4 bits (124), Expect = 6e-07
Identities = 51/227 (22%), Positives = 86/227 (37%), Gaps = 50/227 (22%)
Query: 51 FLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPS 110
+ H+ V +S G SG D+ A ++ + + ++ + GH V+ +HP
Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRI--FAGHLADVNCTRFHP- 637
Query: 111 NPDLFVTASGDKTIRIWDVRTTKCIAT-VNTKGENINICWSPDGQTIAVGNKDDVVTFID 169
N + T S D+T+R+WDV C+ KG ++ +SP+G+ +A G D V D
Sbjct: 638 NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697
Query: 170 AKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCIC 229
G+G + V + H
Sbjct: 698 I-------------------------------GHGLM----------VGELKGHTDTVCS 716
Query: 230 IKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSH 276
++F G+ A+GS D V LWD ++ F L+ T + H
Sbjct: 717 LRFSRDGEILASGSMDNTVRLWD-----AIKAFEDLETDDFTTATGH 758
Score = 43.9 bits (102), Expect = 2e-04
Identities = 28/102 (27%), Positives = 55/102 (53%), Gaps = 4/102 (3%)
Query: 27 VSSGPSRYVLGMQELFRGHSKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEK 86
V++G + + + ++ G+ R F H +HS+ +S +GR LA+G+ D ++ +
Sbjct: 642 VATGSADRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700
Query: 87 DRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWD 128
+V E +GH D+V L + + ++ + S D T+R+WD
Sbjct: 701 GLMVGE--LKGHTDTVCSLRF-SRDGEILASGSMDNTVRLWD 739
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 67.0 bits (162), Expect = 2e-11
Identities = 47/211 (22%), Positives = 95/211 (45%), Gaps = 7/211 (3%)
Query: 46 SKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQL 105
+K + H+ + + +++ ++ + S D T +++ +E +L++ ++ GHG V L
Sbjct: 144 AKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQ--SFHGHGADVLCL 201
Query: 106 CWHPSNP-DLFVTASGDKTIRIWDVRTTKCIATVNTKGENIN-ICWSPDGQTIAVGNKDD 163
PS + FV+ DK +WD+R+ +C+ T +IN + + P G A G+ D
Sbjct: 202 DLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDA 261
Query: 164 VVTFIDAKTHRSKA---EEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSI 220
D + R A +E F + + ++ + F + IN+ + V +
Sbjct: 262 TCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSIL 321
Query: 221 NAHPSNCICIKFDPMGKYFATGSADALVSLW 251
H + ++ P G F +GS D + +W
Sbjct: 322 FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 59.3 bits (142), Expect = 5e-09
Identities = 45/202 (22%), Positives = 85/202 (42%), Gaps = 11/202 (5%)
Query: 96 RGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINIC-WSPDGQ 154
+GHG+ V + W + V++S D + +WD TT V + C ++P G
Sbjct: 60 KGHGNKVLCMDWCKDKRRI-VSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGC 118
Query: 155 TIAVGNKDDVVTF----IDAKTHRSKAEEQFKFEVNEIS---WNNDNNMFFLTNGNGCIN 207
IA G D+ + D + + ++ N +S + N + +G+G
Sbjct: 119 AIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCA 178
Query: 208 ILSYPELKPVQSINAHPSNCICIKFDPM--GKYFATGSADALVSLWDVDELVCVRCFSRL 265
+ + +QS + H ++ +C+ P G F +G D +WD+ CV+ F
Sbjct: 179 LWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETH 238
Query: 266 DWPVRTLSFSHDGKMLASASED 287
+ + ++ + G AS S+D
Sbjct: 239 ESDINSVRYYPSGDAFASGSDD 260
Score = 53.1 bits (126), Expect = 4e-07
Identities = 53/253 (20%), Positives = 102/253 (40%), Gaps = 51/253 (20%)
Query: 58 VHSVAWSCDGRRLASGSFDKTASVFLLEKDR----LVKENNYRGHGDSVDQLCWHPSNPD 113
V + A++ G +A G D SV+ L D+ K+ + H + + + S+
Sbjct: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQ 167
Query: 114 LFVTASGDKTIRIWDVRTTKCIATVNTKGENI---NICWSPDGQTIAVGNKDDVVTFIDA 170
+ +TASGD T +WDV + + + + + G ++ ++ S G T G D D
Sbjct: 168 I-LTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDM 226
Query: 171 KTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICI 230
++ + VQ+ H S+ +
Sbjct: 227 RSGQC-----------------------------------------VQAFETHESDINSV 245
Query: 231 KFDPMGKYFATGSADALVSLWDV--DELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDH 288
++ P G FA+GS DA L+D+ D V + + + ++ FS G++L + D+
Sbjct: 246 RYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDY 305
Query: 289 FIDIAEVETGDKL 301
I++ +V G ++
Sbjct: 306 TINVWDVLKGSRV 318
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 67.0 bits (162), Expect = 2e-11
Identities = 47/211 (22%), Positives = 95/211 (45%), Gaps = 7/211 (3%)
Query: 46 SKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQL 105
+K + H+ + + +++ ++ + S D T +++ +E +L++ ++ GHG V L
Sbjct: 186 AKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQ--SFHGHGADVLCL 243
Query: 106 CWHPSNP-DLFVTASGDKTIRIWDVRTTKCIATVNTKGENIN-ICWSPDGQTIAVGNKDD 163
PS + FV+ DK +WD+R+ +C+ T +IN + + P G A G+ D
Sbjct: 244 DLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDA 303
Query: 164 VVTFIDAKTHRSKA---EEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSI 220
D + R A +E F + + ++ + F + IN+ + V +
Sbjct: 304 TCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSIL 363
Query: 221 NAHPSNCICIKFDPMGKYFATGSADALVSLW 251
H + ++ P G F +GS D + +W
Sbjct: 364 FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 59.3 bits (142), Expect = 5e-09
Identities = 45/202 (22%), Positives = 85/202 (42%), Gaps = 11/202 (5%)
Query: 96 RGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINIC-WSPDGQ 154
+GHG+ V + W + V++S D + +WD TT V + C ++P G
Sbjct: 102 KGHGNKVLCMDWCKDKRRI-VSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGC 160
Query: 155 TIAVGNKDDVVTF----IDAKTHRSKAEEQFKFEVNEIS---WNNDNNMFFLTNGNGCIN 207
IA G D+ + D + + ++ N +S + N + +G+G
Sbjct: 161 AIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCA 220
Query: 208 ILSYPELKPVQSINAHPSNCICIKFDPM--GKYFATGSADALVSLWDVDELVCVRCFSRL 265
+ + +QS + H ++ +C+ P G F +G D +WD+ CV+ F
Sbjct: 221 LWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETH 280
Query: 266 DWPVRTLSFSHDGKMLASASED 287
+ + ++ + G AS S+D
Sbjct: 281 ESDINSVRYYPSGDAFASGSDD 302
Score = 53.1 bits (126), Expect = 4e-07
Identities = 53/253 (20%), Positives = 102/253 (40%), Gaps = 51/253 (20%)
Query: 58 VHSVAWSCDGRRLASGSFDKTASVFLLEKDR----LVKENNYRGHGDSVDQLCWHPSNPD 113
V + A++ G +A G D SV+ L D+ K+ + H + + + S+
Sbjct: 150 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQ 209
Query: 114 LFVTASGDKTIRIWDVRTTKCIATVNTKGENI---NICWSPDGQTIAVGNKDDVVTFIDA 170
+ +TASGD T +WDV + + + + + G ++ ++ S G T G D D
Sbjct: 210 I-LTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDM 268
Query: 171 KTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICI 230
++ + VQ+ H S+ +
Sbjct: 269 RSGQC-----------------------------------------VQAFETHESDINSV 287
Query: 231 KFDPMGKYFATGSADALVSLWDV--DELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDH 288
++ P G FA+GS DA L+D+ D V + + + ++ FS G++L + D+
Sbjct: 288 RYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDY 347
Query: 289 FIDIAEVETGDKL 301
I++ +V G ++
Sbjct: 348 TINVWDVLKGSRV 360
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 66.6 bits (161), Expect = 3e-11
Identities = 44/144 (30%), Positives = 71/144 (49%), Gaps = 5/144 (3%)
Query: 190 WNNDNNMFFLTNGNGC----INILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSAD 245
W+ D + + L +G + S+ P++ H ++ C+KF P Y ATGS D
Sbjct: 388 WDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTD 447
Query: 246 ALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQ 305
V LW + VR F+ PV +L+FS +GK LASA ED + + ++ +G E++
Sbjct: 448 KTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELR 507
Query: 306 CESPTFT-VAWHPKRPLLAFACDD 328
+ T + + P L+A A D
Sbjct: 508 GHTDNITSLTFSPDSGLIASASMD 531
Score = 57.0 bits (136), Expect = 2e-08
Identities = 33/91 (36%), Positives = 50/91 (54%), Gaps = 3/91 (3%)
Query: 46 SKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQL 105
+ R F H V S+A+S +G+ LAS D+ ++ L L KE RGH D++ L
Sbjct: 459 NSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKE--LRGHTDNITSL 516
Query: 106 CWHPSNPDLFVTASGDKTIRIWDVRTTKCIA 136
+ P + L +AS D ++R+WD+R T C A
Sbjct: 517 TFSPDS-GLIASASMDNSVRVWDIRNTYCSA 546
Score = 52.8 bits (125), Expect = 5e-07
Identities = 47/189 (24%), Positives = 73/189 (38%), Gaps = 45/189 (23%)
Query: 71 ASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVR 130
ASGS D+TA ++ DR Y GH VD + +HP N + T S DKT+R+W +
Sbjct: 400 ASGSHDRTARLWSF--DRTYPLRIYAGHLADVDCVKFHP-NSNYLATGSTDKTVRLWSAQ 456
Query: 131 TTKCIAT-VNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQFKFEVNEIS 189
+ +G +++ +SP+G+ +A +D + D
Sbjct: 457 QGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD-------------------- 496
Query: 190 WNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVS 249
L +G Y EL+ H N + F P A+ S D V
Sbjct: 497 ---------LASGT------LYKELR------GHTDNITSLTFSPDSGLIASASMDNSVR 535
Query: 250 LWDVDELVC 258
+WD+ C
Sbjct: 536 VWDIRNTYC 544
Score = 45.4 bits (106), Expect = 7e-05
Identities = 54/249 (21%), Positives = 101/249 (40%), Gaps = 20/249 (8%)
Query: 63 WSCDGRRLASGSFDKTASVFLLEKDRLVKENN-----------YRGHGDSVDQLCWHPSN 111
WS ++L S S L D L +E++ RGH V + +
Sbjct: 295 WSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADS 354
Query: 112 PDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICW----SPDGQTIAVGNKDDVVTF 167
L ++ S D +IR WD+ + TV +G + W SP A G+ D
Sbjct: 355 SGL-LSCSEDMSIRYWDLGSFT--NTVLYQGHAYPV-WDLDISPYSLYFASGSHDRTARL 410
Query: 168 IDA-KTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSN 226
+T+ + +V+ + ++ ++N + + + + S + V+ H
Sbjct: 411 WSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGP 470
Query: 227 CICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASE 286
+ + F P GKY A+ D + LWD+ + + +L+FS D ++ASAS
Sbjct: 471 VLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASM 530
Query: 287 DHFIDIAEV 295
D+ + + ++
Sbjct: 531 DNSVRVWDI 539
Score = 44.7 bits (104), Expect = 1e-04
Identities = 33/124 (26%), Positives = 59/124 (47%), Gaps = 4/124 (3%)
Query: 49 REFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWH 108
R + H A V V + + LA+GS DKT ++ ++ V+ + GH V L +
Sbjct: 420 RIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVR--LFTGHRGPVLSLAFS 477
Query: 109 PSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENI-NICWSPDGQTIAVGNKDDVVTF 167
P N +A D+ +++WD+ + + +NI ++ +SPD IA + D+ V
Sbjct: 478 P-NGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRV 536
Query: 168 IDAK 171
D +
Sbjct: 537 WDIR 540
Score = 28.5 bits (62), Expect = 9.4
Identities = 25/107 (23%), Positives = 43/107 (40%), Gaps = 7/107 (6%)
Query: 243 SADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDKLW 302
S D + WD+ + +PV L S AS S D A + + D+ +
Sbjct: 361 SEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDR---TARLWSFDRTY 417
Query: 303 EVQCESPTFT----VAWHPKRPLLAFACDDKDGKYDSSREAGTVKLF 345
++ + V +HP LA DK + S+++ +V+LF
Sbjct: 418 PLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLF 464
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 65.9 bits (159), Expect = 5e-11
Identities = 44/197 (22%), Positives = 86/197 (43%), Gaps = 6/197 (3%)
Query: 96 RGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINIC-WSPDGQ 154
RGH + + W ++ L V+AS D + IWD TT + + + + C ++P G
Sbjct: 52 RGHLAKIYAMHWG-TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110
Query: 155 TIAVGNKDDVVTFIDAKTHRS--KAEEQFKFEVNEISWNN--DNNMFFLTNGNGCINILS 210
+A G D++ + + KT + + +S D+N ++G+ +
Sbjct: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWD 170
Query: 211 YPELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVR 270
+ + H + + + P + F +G+ DA LWDV E +C + F+ + +
Sbjct: 171 IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDIN 230
Query: 271 TLSFSHDGKMLASASED 287
+ F +G A+ S+D
Sbjct: 231 AICFFPNGNAFATGSDD 247
Score = 58.2 bits (139), Expect = 1e-08
Identities = 45/209 (21%), Positives = 87/209 (41%), Gaps = 8/209 (3%)
Query: 48 TREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCW 107
+RE H+ + S D ++ + S D T +++ +E + + + GH V L
Sbjct: 136 SRELAGHTGYL-SCCRFLDDNQIVTSSGDTTCALWDIETGQ--QTTTFTGHTGDVMSLSL 192
Query: 108 HPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENIN-ICWSPDGQTIAVGNKDDVVT 166
P LFV+ + D + ++WDVR C T +IN IC+ P+G A G+ D
Sbjct: 193 APDTR-LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCR 251
Query: 167 FIDAKTHR---SKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAH 223
D + + + + + + +S++ + + N+ + + H
Sbjct: 252 LFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGH 311
Query: 224 PSNCICIKFDPMGKYFATGSADALVSLWD 252
+ C+ G ATGS D+ + +W+
Sbjct: 312 DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 51.2 bits (121), Expect = 1e-06
Identities = 56/264 (21%), Positives = 99/264 (37%), Gaps = 56/264 (21%)
Query: 46 SKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYR------GHG 99
+K S+ V + A++ G +A G D S++ L+ +E N R GH
Sbjct: 88 NKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK----TREGNVRVSRELAGHT 143
Query: 100 DSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIAT-VNTKGENINICWSPDGQTIAV 158
+ C + + VT+SGD T +WD+ T + T G+ +++ +PD +
Sbjct: 144 GYLS--CCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS 201
Query: 159 GNKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQ 218
G D D + + Q
Sbjct: 202 GACDASAKLWDVREGMCR-----------------------------------------Q 220
Query: 219 SINAHPSNCICIKFDPMGKYFATGSADALVSLWDV--DELVCVRCFSRLDWPVRTLSFSH 276
+ H S+ I F P G FATGS DA L+D+ D+ + + + ++SFS
Sbjct: 221 TFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSK 280
Query: 277 DGKMLASASEDHFIDIAEVETGDK 300
G++L + +D ++ + D+
Sbjct: 281 SGRLLLAGYDDFNCNVWDALKADR 304
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,366,127
Number of Sequences: 37866
Number of extensions: 639315
Number of successful extensions: 3865
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 225
Number of HSP's successfully gapped in prelim test: 97
Number of HSP's that attempted gapping in prelim test: 1746
Number of HSP's gapped (non-prelim): 1289
length of query: 351
length of database: 18,247,518
effective HSP length: 103
effective length of query: 248
effective length of database: 14,347,320
effective search space: 3558135360
effective search space used: 3558135360
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.