BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|14149694 retina specific protein PAL [Homo sapiens] (623 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|14149694 retina specific protein PAL [Homo sapiens] 1256 0.0 gi|193083136 leucine-rich repeat, immunoglobulin-like and transm... 337 3e-92 gi|62988340 leucine rich repeat containing 22 [Homo sapiens] 190 4e-48 gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 124 3e-28 gi|41582239 immunoglobulin superfamily containing leucine-rich r... 110 3e-24 gi|5031809 immunoglobulin superfamily containing leucine-rich re... 110 3e-24 gi|13375646 leucine rich repeat and fibronectin type III domain ... 106 7e-23 gi|194306623 immunoglobulin superfamily containing leucine-rich ... 105 1e-22 gi|194306621 immunoglobulin superfamily containing leucine-rich ... 105 1e-22 gi|39930401 immunoglobulin superfamily containing leucine-rich r... 105 1e-22 gi|194306618 immunoglobulin superfamily containing leucine-rich ... 105 1e-22 gi|4759146 slit homolog 2 [Homo sapiens] 103 4e-22 gi|188528675 slit homolog 1 [Homo sapiens] 103 5e-22 gi|27363458 leucine rich repeat and fibronectin type III domain ... 101 2e-21 gi|31542244 leucine rich repeat and fibronectin type III domain ... 100 3e-21 gi|11321571 slit homolog 3 [Homo sapiens] 95 2e-19 gi|126517478 peroxidasin homolog-like [Homo sapiens] 93 6e-19 gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho... 93 6e-19 gi|149773484 leucine rich repeat and fibronectin type III domain... 92 1e-18 gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 89 9e-18 gi|12007646 nyctalopin precursor [Homo sapiens] 88 3e-17 gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho... 87 6e-17 gi|109150416 peroxidasin [Homo sapiens] 85 2e-16 gi|55741571 leucine rich repeat and fibronectin type III domain ... 83 7e-16 gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 82 1e-15 gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 81 3e-15 gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens] 79 2e-14 gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 79 2e-14 gi|51317373 netrin-G1 ligand [Homo sapiens] 78 3e-14 gi|194440719 chondroadherin-like [Homo sapiens] 77 5e-14 >gi|14149694 retina specific protein PAL [Homo sapiens] Length = 623 Score = 1256 bits (3249), Expect = 0.0 Identities = 623/623 (100%), Positives = 623/623 (100%) Query: 1 MRVALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPD 60 MRVALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPD Sbjct: 1 MRVALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPD 60 Query: 61 TSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLA 120 TSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLA Sbjct: 61 TSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLA 120 Query: 121 AFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAH 180 AFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAH Sbjct: 121 AFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAH 180 Query: 181 LETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG 240 LETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG Sbjct: 181 LETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG 240 Query: 241 VAFSQLELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVH 300 VAFSQLELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVH Sbjct: 241 VAFSQLELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVH 300 Query: 301 QEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGA 360 QEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGA Sbjct: 301 QEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGA 360 Query: 361 LWARTGGGGEAAAYNNKLVARHVPQIPKPAVLATGPSVPSTKEELTLEHFQMDALGELSD 420 LWARTGGGGEAAAYNNKLVARHVPQIPKPAVLATGPSVPSTKEELTLEHFQMDALGELSD Sbjct: 361 LWARTGGGGEAAAYNNKLVARHVPQIPKPAVLATGPSVPSTKEELTLEHFQMDALGELSD 420 Query: 421 GRAGPSEARMVRSVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQHSMRRVIVQPGK 480 GRAGPSEARMVRSVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQHSMRRVIVQPGK Sbjct: 421 GRAGPSEARMVRSVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQHSMRRVIVQPGK 480 Query: 481 TRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFSTNEVVDAENTQQLINVVVISVAIVIA 540 TRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFSTNEVVDAENTQQLINVVVISVAIVIA Sbjct: 481 TRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFSTNEVVDAENTQQLINVVVISVAIVIA 540 Query: 541 LPLTLLVCCSALQKRCRKCFNKDSTEATVTYVNLERLGYSEDGLEELSRHSVSEADRLLS 600 LPLTLLVCCSALQKRCRKCFNKDSTEATVTYVNLERLGYSEDGLEELSRHSVSEADRLLS Sbjct: 541 LPLTLLVCCSALQKRCRKCFNKDSTEATVTYVNLERLGYSEDGLEELSRHSVSEADRLLS 600 Query: 601 ARSSVDFQAFGVKGGRRINEYFC 623 ARSSVDFQAFGVKGGRRINEYFC Sbjct: 601 ARSSVDFQAFGVKGGRRINEYFC 623 >gi|193083136 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 [Homo sapiens] Length = 634 Score = 337 bits (863), Expect = 3e-92 Identities = 212/638 (33%), Positives = 321/638 (50%), Gaps = 68/638 (10%) Query: 49 DMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRR 108 DM P ++P DT +LR+E+T IRR+ EAF L L+ LW+ YN+++ ++ L++ Sbjct: 2 DMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQ 61 Query: 109 LRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLM 168 L ELRL GN LAAFPWA+L D P LR LDL N++++VP EA R+L+NL +LDLSSN+L Sbjct: 62 LHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLT 121 Query: 169 RLPQELIVSWAHLETGIFPPG----HHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLA 224 LP + + SW HL + P G R +LGLQDNPW CDC + ++ L P + Sbjct: 122 TLPPDFLESWTHLVS--TPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIV 179 Query: 225 FIETELRCASPRSLAGVAFSQLELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPE 284 ++ + C+ P L G+ F + EL C P + I S LG LLRC ATG P P+ Sbjct: 180 LLDPLMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQ 239 Query: 285 MSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLI 344 ++W R++ P+N TV QE +G W+++ L +S D+GDY C+AKN G SE V+++ Sbjct: 240 ITWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVT 299 Query: 345 VTE------PPTSTEHSGSPGALWARTGGG-----GEAAAY-------NNKLVARHVPQI 386 V PP ++E +G + G G A++Y + Sbjct: 300 VLGITTTPIPPDTSERTGDHPEWDVQPGSGRSTSVSSASSYLWSSSFSPTSSFSASTLSP 359 Query: 387 PKPAVLATGPSVPSTKEELTLEHFQMDALGELSDGRA------GPSEARMVR-------- 432 P A + P ST T + A +++ R+ G ++ + Sbjct: 360 PSTASFSLSPFSSSTVSSTTTLSTSISASTTMANKRSFQLHQGGKRNLKVAKNGSKLPPA 419 Query: 433 ------------------------SVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQ 468 +++VV +T SV+L W + +A +VLY+ +G Sbjct: 420 STSKKEELALLDQTMLTETNAAIENLRVVSETKESVTLTWNMINTTHNSAVTVLYSKYGG 479 Query: 469 HSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFSTNEVVDAENTQQLI 528 + + K +VTI GL P +Y+ACVC +G+ P+K+QC+ FST E V+ +++Q + Sbjct: 480 KDLLLLNADSSKNQVTIDGLEPGGQYMACVCPKGVPPQKDQCITFST-ERVEGDDSQWSL 538 Query: 529 NVVVISVAIVIALPLTLLVCCSALQKRCRKCFNKDSTEATVTYVNLERLGYSEDGLEEL- 587 +VV S A V+ LPL + + +C+ + A TY+ E L + EL Sbjct: 539 LLVVTSTACVVILPLICFLLYKVCKLQCKSEPFWEDDLAKETYIQFETLFPRSQSVGELW 598 Query: 588 -SRHSVSEADRLLSARSSVDFQ-AFGVKGGRRINEYFC 623 H LL +RSSV+ Q F +G R EY+C Sbjct: 599 TRSHRDDSEKLLLCSRSSVESQVTFKSEGSR--PEYYC 634 >gi|62988340 leucine rich repeat containing 22 [Homo sapiens] Length = 550 Score = 190 bits (482), Expect = 4e-48 Identities = 113/330 (34%), Positives = 168/330 (50%), Gaps = 8/330 (2%) Query: 19 ARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEA 78 A+ FC C+CS G RT+ C + P ++ + ++R+E + + +P + Sbjct: 20 AQPFCLPGCTCSEESFG-----RTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGS 74 Query: 79 FRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDL 138 F + LE LWL +N +S ++ L L LRELRL GN+L + PW A R P LR+LDL Sbjct: 75 FINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDL 134 Query: 139 QANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHH---PRRV 195 + N++ A+P A +FL +LT+LDLSSN+L + + + ++W + P V Sbjct: 135 KRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLV 194 Query: 196 LGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQLELRKCQGPE 255 + L DNPW CDCRL LV + + + + L C P S AG F + EL C P+ Sbjct: 195 VALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMKPQ 254 Query: 256 LHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGL 315 + A+I G LRC A P P ++W V + + T+ + L + Sbjct: 255 ISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSELAI 314 Query: 316 PAVSHLDSGDYICQAKNFLGASETVISLIV 345 PA +DSG+Y C A N +G S VISL V Sbjct: 315 PAAHLVDSGNYTCMASNSIGKSNLVISLHV 344 Score = 63.2 bits (152), Expect = 7e-10 Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 2/126 (1%) Query: 420 DGRAGPSEARMVRSVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQHSMRRVI-VQP 478 D + PSE ++VV T H + L W A + + LY + + V+ + P Sbjct: 354 DSLSIPSEGNAYIDLRVVKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEVVHIGP 413 Query: 479 GKTRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFST-NEVVDAENTQQLINVVVISVAI 537 G + LLP TKY AC+ ++G P + QCV F T + E + L++V V+ + Sbjct: 414 GINTYAVDDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTVVLCVV 473 Query: 538 VIALPL 543 ++A+P+ Sbjct: 474 LLAVPV 479 >gi|229089140 leucine rich repeat containing 24 [Homo sapiens] Length = 513 Score = 124 bits (311), Expect = 3e-28 Identities = 119/407 (29%), Positives = 167/407 (41%), Gaps = 70/407 (17%) Query: 4 ALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSR 63 A +L LL L P +A G CP+ C C + TV C + + P IPP T Sbjct: 5 APALLPLLLLLLPLRAAG-CPAACRCY---------SATVECGALRLRVVPLGIPPGTQT 54 Query: 64 LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLR------------------- 104 L L+ I R+ A PL L +L+L N+L L A R Sbjct: 55 LFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLR 114 Query: 105 -----GLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTF 159 GL +LR L L GN+LA P+L+ L LQ N + + +A L +L Sbjct: 115 SGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLAL 174 Query: 160 LDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDL-VHLLDG 218 LDLS NQL + +E + A L+ VL L +NPW CDC L+ L + +G Sbjct: 175 LDLSRNQLGTISREALQPLASLQ------------VLRLTENPWRCDCALHWLGAWIKEG 222 Query: 219 WAPNLAFIETELRCASP-----RSLAGVAFSQLELRKCQGPELHPGVASIRSLLGGTALL 273 L + ++ CA P +SL V+ S L C P +H + + LG + Sbjct: 223 GQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSL---ICIPPSVHVQPLELTANLGEDLRV 279 Query: 274 RCGATGVPGPEMSWRRA----NGRP---------LNGTVHQEVSSDGTSWTLLGLPAVSH 320 C A+G P P ++WR+ GRP L G S G+ L ++H Sbjct: 280 ACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAH 339 Query: 321 LDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGALWARTGG 367 +G Y C+A N GA+ L+V + P AR G Sbjct: 340 --AGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPPPAARPAG 384 >gi|41582239 immunoglobulin superfamily containing leucine-rich repeat [Homo sapiens] Length = 428 Score = 110 bits (276), Expect = 3e-24 Identities = 98/372 (26%), Positives = 146/372 (39%), Gaps = 56/372 (15%) Query: 5 LGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRL 64 L +LW L QA CP C C G+ + C D+ P P + + L Sbjct: 4 LHLLWWALLLGLAQA---CPEPCDC-----GEKYGFQIADCAYRDLESVPPGFPANVTTL 55 Query: 65 RLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPW 124 L + +P AFR + L+ LWL +N + + A L L L+ L L N ++ F W Sbjct: 56 SLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAW 115 Query: 125 AALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETG 184 + L + L+LL + +N L+ +P +A R L L L L+ N+L L + G Sbjct: 116 SDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAE-----------G 164 Query: 185 IFPP----GHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFI---ETELRCASPRS 237 F P H L + +NP+ C C + L WA A + + C SP Sbjct: 165 TFTPLTALSH-----LQINENPFDCTCGIV----WLKTWALTTAVSIPEQDNIACTSPHV 215 Query: 238 LAGVAFSQLELRKCQGPEL----HPGVASIRSLLGGTALLRCGATGVPGPEMSWR----- 288 L G S+L C P + P G L C G P P++ W Sbjct: 216 LKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPS 275 Query: 289 ----------RANGRPLNGT--VHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGA 336 +GR L GT + + L +P L+ G Y C A N LG+ Sbjct: 276 GIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGS 335 Query: 337 SETVISLIVTEP 348 +E+ + + + P Sbjct: 336 AESSVDVALATP 347 >gi|5031809 immunoglobulin superfamily containing leucine-rich repeat [Homo sapiens] Length = 428 Score = 110 bits (276), Expect = 3e-24 Identities = 98/372 (26%), Positives = 146/372 (39%), Gaps = 56/372 (15%) Query: 5 LGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRL 64 L +LW L QA CP C C G+ + C D+ P P + + L Sbjct: 4 LHLLWWALLLGLAQA---CPEPCDC-----GEKYGFQIADCAYRDLESVPPGFPANVTTL 55 Query: 65 RLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPW 124 L + +P AFR + L+ LWL +N + + A L L L+ L L N ++ F W Sbjct: 56 SLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAW 115 Query: 125 AALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETG 184 + L + L+LL + +N L+ +P +A R L L L L+ N+L L + G Sbjct: 116 SDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAE-----------G 164 Query: 185 IFPP----GHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFI---ETELRCASPRS 237 F P H L + +NP+ C C + L WA A + + C SP Sbjct: 165 TFTPLTALSH-----LQINENPFDCTCGIV----WLKTWALTTAVSIPEQDNIACTSPHV 215 Query: 238 LAGVAFSQLELRKCQGPEL----HPGVASIRSLLGGTALLRCGATGVPGPEMSWR----- 288 L G S+L C P + P G L C G P P++ W Sbjct: 216 LKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPS 275 Query: 289 ----------RANGRPLNGT--VHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGA 336 +GR L GT + + L +P L+ G Y C A N LG+ Sbjct: 276 GIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGS 335 Query: 337 SETVISLIVTEP 348 +E+ + + + P Sbjct: 336 AESSVDVALATP 347 >gi|13375646 leucine rich repeat and fibronectin type III domain containing 3 [Homo sapiens] Length = 628 Score = 106 bits (264), Expect = 7e-23 Identities = 116/401 (28%), Positives = 150/401 (37%), Gaps = 78/401 (19%) Query: 7 MLWLLALA---WPPQAR--GFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDT 61 +L LL LA PPQ+ CP +C C S +V+C + P S+ Sbjct: 7 LLCLLPLAPASSPPQSATPSPCPRRCRCQTQ-----SLPLSVLCPGAGLLFVPPSLDRRA 61 Query: 62 SRLRL------------------------ERTAIRRVPGEAFRPLGRLEQLWLPYNALSE 97 + LRL R IR V AF L L L L N L+ Sbjct: 62 AELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTS 121 Query: 98 LNALMLRGLRRLRELRLPGNRLAAF-------------------------PWAALRDAPK 132 L LRGL LR L L N+LAA PW AL Sbjct: 122 LGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGN 181 Query: 133 LRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHP 192 + L L N L++VPA A L L LD++SN+L +P + + S L + P P Sbjct: 182 VNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPL---LARPRGSP 238 Query: 193 RR--VLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQL--EL 248 VL NP C+C L W LA + CASP +L G F + E Sbjct: 239 ASALVLAFGGNPLHCNCELV--------WLRRLAREDDLEACASPPALGGRYFWAVGEEE 290 Query: 249 RKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGT 308 C+ P + + G A LRC A G P P + W GR L + +GT Sbjct: 291 FVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGT 350 Query: 309 SWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPP 349 L+ P D G + C A N G + + L V PP Sbjct: 351 LELLVTEPG----DGGIFTCIAANAAGEATAAVELTVGPPP 387 >gi|194306623 immunoglobulin superfamily containing leucine-rich repeat 2 [Homo sapiens] Length = 745 Score = 105 bits (262), Expect = 1e-22 Identities = 155/655 (23%), Positives = 244/655 (37%), Gaps = 145/655 (22%) Query: 4 ALGMLW-LLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTS 62 AL ++W LL +A G CP C+C D + C ++ P +P + + Sbjct: 6 ALWLVWALLGVA------GSCPEPCACV-----DKYAHQFADCAYKELREVPEGLPANVT 54 Query: 63 RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122 L L I + AF + ++ LWL +N + + L L +L+ L L N +++F Sbjct: 55 TLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSF 114 Query: 123 PWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQ---ELIVSWA 179 PW+ LR+ L+LL + NRL ++P +A L +L L +++N+L L + + + + Sbjct: 115 PWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALS 174 Query: 180 HLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETE---LRCASPR 236 HL+ L NP+ C C L L WA + E + CASP Sbjct: 175 HLQ---------------LYHNPFHCGCGLV----WLQAWAASTRVSLPEPDSIACASPP 215 Query: 237 SLAGVAFSQLELRKCQGPELH-----PGVASIRSLLGGTA-LLRCGATGVPGPEMSWR-- 288 +L GV +L C P +H P A L G A +L C A G P P + W+ Sbjct: 216 ALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQ 275 Query: 289 ---------------------------RANGRPLNGTVHQEVSSDGTSWTL--------- 312 +G L T + + +W Sbjct: 276 IPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQT-QAQTPTPAPAWPAPPATPRFLA 334 Query: 313 -----LGLPAVSHLDSGDYICQAKNFLGASETVISLIV--TEPPTSTEHSGSPGALWART 365 L +P +S ++G Y C+A N LGA+ T I + V T PP +G A T Sbjct: 335 LANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPT 394 Query: 366 GGGGEAAAYNNKLVARHVPQ-------IPKPAVLA---TGPSVPSTKEELTLEHFQMDAL 415 A V P+ + K ++L T P +++ E + D Sbjct: 395 SERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETETEPEEDTSEGEEAEDQILADPA 454 Query: 416 GELSDGRAGPS----------EARMVRSVKVVG----DTYHSVSLVWKAPQA-------- 453 E G PS A + V +G D + V P A Sbjct: 455 EEQRCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPG 514 Query: 454 ---------KNTTAFSVLYAVFGQHSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLV 504 + L G +++ V+ G GL P T Y C+ + G Sbjct: 515 GAGGAPRPGRRPLRLLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAG-- 572 Query: 505 PRKEQC---VIFSTNEVVDAENTQQLINVVVISVAIVI--ALPLTLLVCCSALQK 554 E C V+FST + + + L+ +V +SV +++ +PL CC L K Sbjct: 573 ---EACHVQVVFSTKKELPS-----LLVIVAVSVFLLVLATVPLLGAACCHLLAK 619 >gi|194306621 immunoglobulin superfamily containing leucine-rich repeat 2 [Homo sapiens] Length = 745 Score = 105 bits (262), Expect = 1e-22 Identities = 155/655 (23%), Positives = 244/655 (37%), Gaps = 145/655 (22%) Query: 4 ALGMLW-LLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTS 62 AL ++W LL +A G CP C+C D + C ++ P +P + + Sbjct: 6 ALWLVWALLGVA------GSCPEPCACV-----DKYAHQFADCAYKELREVPEGLPANVT 54 Query: 63 RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122 L L I + AF + ++ LWL +N + + L L +L+ L L N +++F Sbjct: 55 TLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSF 114 Query: 123 PWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQ---ELIVSWA 179 PW+ LR+ L+LL + NRL ++P +A L +L L +++N+L L + + + + Sbjct: 115 PWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALS 174 Query: 180 HLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETE---LRCASPR 236 HL+ L NP+ C C L L WA + E + CASP Sbjct: 175 HLQ---------------LYHNPFHCGCGLV----WLQAWAASTRVSLPEPDSIACASPP 215 Query: 237 SLAGVAFSQLELRKCQGPELH-----PGVASIRSLLGGTA-LLRCGATGVPGPEMSWR-- 288 +L GV +L C P +H P A L G A +L C A G P P + W+ Sbjct: 216 ALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQ 275 Query: 289 ---------------------------RANGRPLNGTVHQEVSSDGTSWTL--------- 312 +G L T + + +W Sbjct: 276 IPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQT-QAQTPTPAPAWPAPPATPRFLA 334 Query: 313 -----LGLPAVSHLDSGDYICQAKNFLGASETVISLIV--TEPPTSTEHSGSPGALWART 365 L +P +S ++G Y C+A N LGA+ T I + V T PP +G A T Sbjct: 335 LANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPT 394 Query: 366 GGGGEAAAYNNKLVARHVPQ-------IPKPAVLA---TGPSVPSTKEELTLEHFQMDAL 415 A V P+ + K ++L T P +++ E + D Sbjct: 395 SERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETETEPEEDTSEGEEAEDQILADPA 454 Query: 416 GELSDGRAGPS----------EARMVRSVKVVG----DTYHSVSLVWKAPQA-------- 453 E G PS A + V +G D + V P A Sbjct: 455 EEQRCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPG 514 Query: 454 ---------KNTTAFSVLYAVFGQHSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLV 504 + L G +++ V+ G GL P T Y C+ + G Sbjct: 515 GAGGAPRPGRRPLRLLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAG-- 572 Query: 505 PRKEQC---VIFSTNEVVDAENTQQLINVVVISVAIVI--ALPLTLLVCCSALQK 554 E C V+FST + + + L+ +V +SV +++ +PL CC L K Sbjct: 573 ---EACHVQVVFSTKKELPS-----LLVIVAVSVFLLVLATVPLLGAACCHLLAK 619 >gi|39930401 immunoglobulin superfamily containing leucine-rich repeat 2 [Homo sapiens] Length = 745 Score = 105 bits (262), Expect = 1e-22 Identities = 155/655 (23%), Positives = 244/655 (37%), Gaps = 145/655 (22%) Query: 4 ALGMLW-LLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTS 62 AL ++W LL +A G CP C+C D + C ++ P +P + + Sbjct: 6 ALWLVWALLGVA------GSCPEPCACV-----DKYAHQFADCAYKELREVPEGLPANVT 54 Query: 63 RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122 L L I + AF + ++ LWL +N + + L L +L+ L L N +++F Sbjct: 55 TLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSF 114 Query: 123 PWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQ---ELIVSWA 179 PW+ LR+ L+LL + NRL ++P +A L +L L +++N+L L + + + + Sbjct: 115 PWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALS 174 Query: 180 HLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETE---LRCASPR 236 HL+ L NP+ C C L L WA + E + CASP Sbjct: 175 HLQ---------------LYHNPFHCGCGLV----WLQAWAASTRVSLPEPDSIACASPP 215 Query: 237 SLAGVAFSQLELRKCQGPELH-----PGVASIRSLLGGTA-LLRCGATGVPGPEMSWR-- 288 +L GV +L C P +H P A L G A +L C A G P P + W+ Sbjct: 216 ALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQ 275 Query: 289 ---------------------------RANGRPLNGTVHQEVSSDGTSWTL--------- 312 +G L T + + +W Sbjct: 276 IPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQT-QAQTPTPAPAWPAPPATPRFLA 334 Query: 313 -----LGLPAVSHLDSGDYICQAKNFLGASETVISLIV--TEPPTSTEHSGSPGALWART 365 L +P +S ++G Y C+A N LGA+ T I + V T PP +G A T Sbjct: 335 LANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPT 394 Query: 366 GGGGEAAAYNNKLVARHVPQ-------IPKPAVLA---TGPSVPSTKEELTLEHFQMDAL 415 A V P+ + K ++L T P +++ E + D Sbjct: 395 SERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETETEPEEDTSEGEEAEDQILADPA 454 Query: 416 GELSDGRAGPS----------EARMVRSVKVVG----DTYHSVSLVWKAPQA-------- 453 E G PS A + V +G D + V P A Sbjct: 455 EEQRCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPG 514 Query: 454 ---------KNTTAFSVLYAVFGQHSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLV 504 + L G +++ V+ G GL P T Y C+ + G Sbjct: 515 GAGGAPRPGRRPLRLLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAG-- 572 Query: 505 PRKEQC---VIFSTNEVVDAENTQQLINVVVISVAIVI--ALPLTLLVCCSALQK 554 E C V+FST + + + L+ +V +SV +++ +PL CC L K Sbjct: 573 ---EACHVQVVFSTKKELPS-----LLVIVAVSVFLLVLATVPLLGAACCHLLAK 619 >gi|194306618 immunoglobulin superfamily containing leucine-rich repeat 2 [Homo sapiens] Length = 745 Score = 105 bits (262), Expect = 1e-22 Identities = 155/655 (23%), Positives = 244/655 (37%), Gaps = 145/655 (22%) Query: 4 ALGMLW-LLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTS 62 AL ++W LL +A G CP C+C D + C ++ P +P + + Sbjct: 6 ALWLVWALLGVA------GSCPEPCACV-----DKYAHQFADCAYKELREVPEGLPANVT 54 Query: 63 RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122 L L I + AF + ++ LWL +N + + L L +L+ L L N +++F Sbjct: 55 TLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSF 114 Query: 123 PWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQ---ELIVSWA 179 PW+ LR+ L+LL + NRL ++P +A L +L L +++N+L L + + + + Sbjct: 115 PWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALS 174 Query: 180 HLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETE---LRCASPR 236 HL+ L NP+ C C L L WA + E + CASP Sbjct: 175 HLQ---------------LYHNPFHCGCGLV----WLQAWAASTRVSLPEPDSIACASPP 215 Query: 237 SLAGVAFSQLELRKCQGPELH-----PGVASIRSLLGGTA-LLRCGATGVPGPEMSWR-- 288 +L GV +L C P +H P A L G A +L C A G P P + W+ Sbjct: 216 ALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQ 275 Query: 289 ---------------------------RANGRPLNGTVHQEVSSDGTSWTL--------- 312 +G L T + + +W Sbjct: 276 IPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQT-QAQTPTPAPAWPAPPATPRFLA 334 Query: 313 -----LGLPAVSHLDSGDYICQAKNFLGASETVISLIV--TEPPTSTEHSGSPGALWART 365 L +P +S ++G Y C+A N LGA+ T I + V T PP +G A T Sbjct: 335 LANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPT 394 Query: 366 GGGGEAAAYNNKLVARHVPQ-------IPKPAVLA---TGPSVPSTKEELTLEHFQMDAL 415 A V P+ + K ++L T P +++ E + D Sbjct: 395 SERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETETEPEEDTSEGEEAEDQILADPA 454 Query: 416 GELSDGRAGPS----------EARMVRSVKVVG----DTYHSVSLVWKAPQA-------- 453 E G PS A + V +G D + V P A Sbjct: 455 EEQRCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPG 514 Query: 454 ---------KNTTAFSVLYAVFGQHSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLV 504 + L G +++ V+ G GL P T Y C+ + G Sbjct: 515 GAGGAPRPGRRPLRLLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAG-- 572 Query: 505 PRKEQC---VIFSTNEVVDAENTQQLINVVVISVAIVI--ALPLTLLVCCSALQK 554 E C V+FST + + + L+ +V +SV +++ +PL CC L K Sbjct: 573 ---EACHVQVVFSTKKELPS-----LLVIVAVSVFLLVLATVPLLGAACCHLLAK 619 >gi|4759146 slit homolog 2 [Homo sapiens] Length = 1529 Score = 103 bits (258), Expect = 4e-22 Identities = 80/252 (31%), Positives = 117/252 (46%), Gaps = 31/252 (12%) Query: 23 CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82 CP+ C+CS +I V C +T P ++P + +RLE+ I+ +P AF P Sbjct: 273 CPAACTCSNNI---------VDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPY 323 Query: 83 GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142 +L ++ L N +SEL +GLR L L L GN++ P + L+LL L AN+ Sbjct: 324 KKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANK 383 Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNP 202 ++ + +A + L NL L L N+L + + G F P + + L NP Sbjct: 384 INCLRVDAFQDLHNLNLLSLYDNKLQTIAK-----------GTFSP-LRAIQTMHLAQNP 431 Query: 203 WACDCRLYDLVHLLDGWAPNLAFIETE-LRCASPRSLAGVAFSQLELRK--CQGPELH-- 257 + CDC L L L + IET RC SPR LA Q++ +K C E + Sbjct: 432 FICDCHLKWLADYL-----HTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFI 486 Query: 258 PGVASIRSLLGG 269 PG RS L G Sbjct: 487 PGTEDYRSKLSG 498 Score = 82.8 bits (203), Expect = 9e-16 Identities = 74/267 (27%), Positives = 108/267 (40%), Gaps = 30/267 (11%) Query: 1 MRVALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPD 60 + ++LG++ + PQA CP+QCSCS TV C+ + P +IP + Sbjct: 9 LSLSLGLVLAILNKVAPQA---CPAQCSCS---------GSTVDCHGLALRSVPRNIPRN 56 Query: 61 TSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLA 120 T RL L I R+ F L L L L N +S + + L+ L LRL N L Sbjct: 57 TERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQ 116 Query: 121 AFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAH 180 FP KL LDL N++ A+P +A R ++ L L NQ+ + + Sbjct: 117 LFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRD 176 Query: 181 LET-----------GIFPPGHHPR-RVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIET 228 LE + H P+ R L N CDC L L W + Sbjct: 177 LEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHL----AWLSDWLRQRPRVGL 232 Query: 229 ELRCASPRSLAGVAFSQLELRK--CQG 253 +C P L G ++++ R+ C G Sbjct: 233 YTQCMGPSHLRGHNVAEVQKREFVCSG 259 Score = 57.0 bits (136), Expect = 5e-08 Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 26/228 (11%) Query: 23 CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEA-FRP 81 CP +C C + TV C++ + P IP T+ LRL + F+ Sbjct: 506 CPEKCRC---------EGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKK 556 Query: 82 LGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQAN 141 L +L ++ N ++++ G + E+ L NRL + L+ L L++N Sbjct: 557 LPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSN 616 Query: 142 RLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDN 201 R++ V N +F+ LSS +L+ L I + A G F H L L N Sbjct: 617 RITCV--------GNDSFIGLSSVRLLSLYDNQITTVA---PGAFDT-LHSLSTLNLLAN 664 Query: 202 PWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQLELR 249 P+ C+C L L W + RC P L + + ++ Sbjct: 665 PFNCNCYL----AWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQ 708 Score = 53.1 bits (126), Expect = 7e-07 Identities = 63/235 (26%), Positives = 84/235 (35%), Gaps = 54/235 (22%) Query: 23 CPSQCSCSLHIMGDGSKARTVV-CNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRP 81 CP++C+C TVV C++ + + P IP D + L L+ VP E Sbjct: 727 CPTECTC----------LDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSN- 775 Query: 82 LGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQAN 141 L + L N +S L+ + +L L L NRL P LRLL L N Sbjct: 776 YKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGN 835 Query: 142 RLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDN 201 +S VP A F DLS + +HL G N Sbjct: 836 DISVVPEGA--------FNDLS-------------ALSHLAIGA---------------N 859 Query: 202 PWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQLELRK--CQGP 254 P CDC + L W + RCA P +A +K CQGP Sbjct: 860 PLYCDCNM----QWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGP 910 >gi|188528675 slit homolog 1 [Homo sapiens] Length = 1534 Score = 103 bits (257), Expect = 5e-22 Identities = 73/231 (31%), Positives = 109/231 (47%), Gaps = 27/231 (11%) Query: 21 GFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFR 80 G CP+ C+CS I V C +T PA++P + +RLE I+ +P AF Sbjct: 280 GSCPAMCTCSNGI---------VDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFS 330 Query: 81 PLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQA 140 P +L ++ L N ++E+ +GLR L L L GN++ P L+LL L A Sbjct: 331 PYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNA 390 Query: 141 NRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQD 200 N+++ + +A + L+NL+ L L N++ L + S ++T L L Sbjct: 391 NKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQT------------LHLAQ 438 Query: 201 NPWACDCRLYDLVHLLDGWAPNLAFIETE-LRCASPRSLAGVAFSQLELRK 250 NP+ CDC L L L IET RCASPR LA Q++ +K Sbjct: 439 NPFICDCNLKWLADFL-----RTNPIETSGARCASPRRLANKRIGQIKSKK 484 Score = 77.4 bits (189), Expect = 4e-14 Identities = 70/254 (27%), Positives = 103/254 (40%), Gaps = 28/254 (11%) Query: 8 LWLL--ALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLR 65 LWLL A AW A CP+ C+C+ TV C+ + P +IP +T RL Sbjct: 18 LWLLLWAAAWRLGASA-CPALCTCT---------GTTVDCHGTGLQAIPKNIPRNTERLE 67 Query: 66 LERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWA 125 L I R+ F L +L L L N + + ++ L LRL N+L P Sbjct: 68 LNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPEL 127 Query: 126 ALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLET-- 183 ++ L LDL N + A+P +A R +L L L NQ+ + + + LE Sbjct: 128 LFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLT 187 Query: 184 ---------GIFPPGHHPR-RVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCA 233 + H P+ R L N CDC L L W I +C+ Sbjct: 188 LNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHL----AWLSQWLRQRPTIGLFTQCS 243 Query: 234 SPRSLAGVAFSQLE 247 P SL G+ ++++ Sbjct: 244 GPASLRGLNVAEVQ 257 Score = 71.2 bits (173), Expect = 3e-12 Identities = 58/214 (27%), Positives = 87/214 (40%), Gaps = 26/214 (12%) Query: 23 CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEA-FRP 81 CP +C C +A V C+ +T P IP T+ LRL I + F+ Sbjct: 513 CPHKCRC---------EANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKK 563 Query: 82 LGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQAN 141 L L+++ L N +SE+ G + EL L N+L + R LR L L+ N Sbjct: 564 LTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNN 623 Query: 142 RLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDN 201 R+S + ++ L N+ L L NQ+ + + L T L L N Sbjct: 624 RISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLST------------LNLLAN 671 Query: 202 PWACDCRLYDLVHLLDGWAPNLAFIETELRCASP 235 P+ C+C+L L GW + RC +P Sbjct: 672 PFNCNCQL----AWLGGWLRKRKIVTGNPRCQNP 701 Score = 46.6 bits (109), Expect = 7e-05 Identities = 40/145 (27%), Positives = 57/145 (39%), Gaps = 34/145 (23%) Query: 23 CPSQCSCSLHIMGDGSKARTVV-CNDPDMTLPPASIPPDTSRLRLERTAIRRVPGE---- 77 CP +C+C TVV C++ + P IP + + L L+ VPG+ Sbjct: 734 CPQECAC----------LDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTF 783 Query: 78 -------------------AFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNR 118 +F + +L L L YNAL + L +GLR LR L L GN Sbjct: 784 KYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGND 843 Query: 119 LAAFPWAALRDAPKLRLLDLQANRL 143 ++ D L L + AN L Sbjct: 844 ISTLQEGIFADVTSLSHLAIGANPL 868 >gi|27363458 leucine rich repeat and fibronectin type III domain containing 4 [Homo sapiens] Length = 635 Score = 101 bits (252), Expect = 2e-21 Identities = 111/373 (29%), Positives = 143/373 (38%), Gaps = 56/373 (15%) Query: 64 LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF- 122 L L R AI R+ AF L L L L N L EL LRG L+ L L GN+L Sbjct: 77 LTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQHLILSGNQLGRIA 136 Query: 123 ------------------------PWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLT 158 PWA + P L L+L N + A+P A L L+ Sbjct: 137 PGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLS 196 Query: 159 FLDLSSNQLMRL-PQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLD 217 LDL+SN+L L P L E P VL NP C+C L Sbjct: 197 RLDLTSNRLATLAPDPLFSRGRDAEASPAP------LVLSFSGNPLHCNCELL------- 243 Query: 218 GWAPNLAFIETELRCASPRSLAGVAFSQLELRK--CQGPELHPGVASIRSLLGGTALLRC 275 W LA + CASP LAG F + + C+ P + + L G A LRC Sbjct: 244 -WLRRLARPDDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQRLWVLEGQRATLRC 302 Query: 276 GATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLG 335 A G P P M W + R + + +GT L + D+G Y C A N G Sbjct: 303 RALGDPAPTMHWVGPDDRLVGNSSRARAFPNGT----LEIGVTGAGDAGGYTCIATNPAG 358 Query: 336 ASETVISLIVTEPP---TSTEHSGSPG----ALWARTGGGGEAAAYNNKLVARHVPQIPK 388 + + L V P S+ G PG A ART GE + V V ++ Sbjct: 359 EATARVELRVLALPHGGNSSAEGGRPGPSDIAASARTAAEGEGTLESEPAV--QVTEVTA 416 Query: 389 PAVLAT-GPSVPS 400 + L + GP P+ Sbjct: 417 TSGLVSWGPGRPA 429 >gi|31542244 leucine rich repeat and fibronectin type III domain containing 5 [Homo sapiens] Length = 719 Score = 100 bits (250), Expect = 3e-21 Identities = 83/302 (27%), Positives = 125/302 (41%), Gaps = 22/302 (7%) Query: 64 LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFP 123 L L + ++ + F L L L L N L+ +++ + L EL L N L P Sbjct: 104 LHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIP 163 Query: 124 WAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHL-- 181 W A+ L L L N + +P L +T LD++SN+L +LP + + A + Sbjct: 164 WDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLA 223 Query: 182 ETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGV 241 +GI P L NP C+C L W L+ + CASP L G Sbjct: 224 TSGIISPSTF---ALSFGGNPLHCNCELL--------WLRRLSREDDLETCASPPLLTGR 272 Query: 242 AFSQL--ELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTV 299 F + E C+ P + +R L G A LRC A G P P + W G+ ++ Sbjct: 273 YFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNAT 332 Query: 300 HQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPP---TSTEHSG 356 V +GT L + + D+G + C A N G + ++ L + + P ST H Sbjct: 333 RSLVYDNGT----LDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNSTNHIH 388 Query: 357 SP 358 P Sbjct: 389 EP 390 >gi|11321571 slit homolog 3 [Homo sapiens] Length = 1523 Score = 95.1 bits (235), Expect = 2e-19 Identities = 70/236 (29%), Positives = 109/236 (46%), Gaps = 29/236 (12%) Query: 23 CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82 CPS C+CS +I V C + PA++P +RLE+ +I+ +P AF Sbjct: 280 CPSPCTCSNNI---------VDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQY 330 Query: 83 GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142 +L+++ + N +S++ +GL+ L L L GN++ L+LL L AN+ Sbjct: 331 KKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANK 390 Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNP 202 ++ + + L+NL L L N+L + + L ++T L L NP Sbjct: 391 INCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQT------------LHLAQNP 438 Query: 203 WACDCRLYDLVHLLDGWAPNLAFIETE-LRCASPRSLAGVAFSQLELRK--CQGPE 255 + CDC L L L IET RC+SPR LA SQ++ +K C G E Sbjct: 439 FVCDCHLKWLADYLQDNP-----IETSGARCSSPRRLANKRISQIKSKKFRCSGSE 489 Score = 85.1 bits (209), Expect = 2e-16 Identities = 73/279 (26%), Positives = 114/279 (40%), Gaps = 29/279 (10%) Query: 2 RVALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDT 61 R+AL + L+ PP CP++C+CS A +V C+ + P IP + Sbjct: 15 RLALALALASVLSGPPAVA--CPTKCTCS---------AASVDCHGLGLRAVPRGIPRNA 63 Query: 62 SRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAA 121 RL L+R I R+ F L L L L N +S + + L++L LRL N+L Sbjct: 64 ERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQV 123 Query: 122 FPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHL 181 P + PKL LDL N++ +P +A R + ++ L L +N + + + L Sbjct: 124 LPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDL 183 Query: 182 E-----------TGIFPPGHHPR-RVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETE 229 E + H P+ R L L N CDC L L W + Sbjct: 184 EILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHL----AWLSDWLRQRRTVGQF 239 Query: 230 LRCASPRSLAGVAFSQLELRK--CQGPELHPGVASIRSL 266 C +P L G + ++ ++ C P P + S+ Sbjct: 240 TLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSI 278 Score = 58.5 bits (140), Expect = 2e-08 Identities = 46/146 (31%), Positives = 64/146 (43%), Gaps = 12/146 (8%) Query: 23 CPSQCSCSLHIMGDGSKARTVV-CNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRP 81 CP QC+C TVV C++ + P +P D + L LE + VP E Sbjct: 725 CPEQCTCM----------ETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRE-LSA 773 Query: 82 LGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQAN 141 L L + L N++S L + L L L NRL P A LR+L L N Sbjct: 774 LRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGN 833 Query: 142 RLSAVPAEAARFLENLTFLDLSSNQL 167 +S+VP + L +L+ L L +N L Sbjct: 834 DISSVPEGSFNDLTSLSHLALGTNPL 859 Score = 43.9 bits (102), Expect = 4e-04 Identities = 29/107 (27%), Positives = 49/107 (45%) Query: 59 PDTSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNR 118 P+ ++ L I+ V AF +++L L N L ++ + RGL L+ L L N Sbjct: 557 PNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNL 616 Query: 119 LAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSN 165 + +RLL L NR++ + A L +L+ ++L SN Sbjct: 617 IGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSN 663 Score = 36.2 bits (82), Expect = 0.093 Identities = 46/161 (28%), Positives = 63/161 (39%), Gaps = 25/161 (15%) Query: 112 LRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLP 171 +R L A P +D +L L + N L+AVP E + L +LT +DLS+N + L Sbjct: 736 VRCSNKGLRALPRGMPKDVTELYL---EGNHLTAVPRELSA-LRHLTLIDLSNNSISMLT 791 Query: 172 QELIVSWAHLETGIFP------------PGHHPRRVLGLQDN-----PWACDCRLYDLVH 214 + +HL T I G RVL L N P L L H Sbjct: 792 NYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSH 851 Query: 215 LLDGWAPNLAFIETELRCASPRSLAGVAFSQLELRKCQGPE 255 L G P + LR S AG + + + +C PE Sbjct: 852 LALGTNP--LHCDCSLRWLSEWVKAG--YKEPGIARCSSPE 888 >gi|126517478 peroxidasin homolog-like [Homo sapiens] Length = 1463 Score = 93.2 bits (230), Expect = 6e-19 Identities = 92/325 (28%), Positives = 131/325 (40%), Gaps = 30/325 (9%) Query: 23 CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82 CPS+C C TV C + P +P T+ L L IR +PG AF+ L Sbjct: 24 CPSRCLCF---------KSTVRCMHLMLDHIP-QVPQQTTVLDLRFNRIREIPGSAFKKL 73 Query: 83 GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142 L L L N + +++ GL L L L N + A + L L + N+ Sbjct: 74 KNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQ 133 Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNP 202 L + E L L L L +N+L ++P S+++L++ + L L N Sbjct: 134 LEMLQPETFGDLLRLERLFLHNNKLSKIPAG---SFSNLDS---------LKRLRLDSNA 181 Query: 203 WACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG--VAFSQLELRKCQGPELHPGV 260 CDC L L LL G+A + + C PR L G VA +E CQ P + Sbjct: 182 LVCDCDLMWLGELLQGFAQH-GHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEP 240 Query: 261 ASIRSLLGGTALLRCGATGVPGPEMSWRRAN-GRPLNGTVHQEVSSDGTSWTLLGLPAVS 319 + G T C A G P PE+ W N L V DGT L + Sbjct: 241 QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGT----LMIRNTR 296 Query: 320 HLDSGDYICQAKNFLGASETVISLI 344 D G Y C A+N G ++T +++ Sbjct: 297 ESDQGVYQCMARNSAGEAKTQSAML 321 Score = 55.1 bits (131), Expect = 2e-07 Identities = 38/122 (31%), Positives = 53/122 (43%), Gaps = 26/122 (21%) Query: 266 LLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGD 325 L+G + L C ATG P P ++W R NG L+G+ H SS L L ++ D G Sbjct: 342 LIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSG------LYLQNITQRDHGR 395 Query: 326 YICQAKNFLGASETVISLIVTEPPTST----------EH----------SGSPGALWART 365 + C A N G + ++IV PP T EH + P +W +T Sbjct: 396 FTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKT 455 Query: 366 GG 367 GG Sbjct: 456 GG 457 Score = 35.8 bits (81), Expect = 0.12 Identities = 24/72 (33%), Positives = 33/72 (45%), Gaps = 7/72 (9%) Query: 275 CGATGVPGPEMSWRRANGR-PLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNF 333 C A G P P + W + G+ P+ G V S GT L + + D G Y CQA + Sbjct: 440 CEADGNPPPVIVWTKTGGQLPVEG--QHTVLSSGT----LRIDRAAQHDQGQYECQAVSS 493 Query: 334 LGASETVISLIV 345 LG + + L V Sbjct: 494 LGVKKVSVQLTV 505 Score = 31.2 bits (69), Expect = 3.0 Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 5/80 (6%) Query: 267 LGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDY 326 +G + C A G P P ++W + G + + V +GT L + D G Y Sbjct: 524 VGKNINISCHAQGEPQPIITWNK-EGVQITESGKFHVDDEGT----LTIYDAGFPDQGRY 578 Query: 327 ICQAKNFLGASETVISLIVT 346 C A+N G + T + L VT Sbjct: 579 ECVARNSFGLAVTNMFLTVT 598 >gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo sapiens] Length = 345 Score = 93.2 bits (230), Expect = 6e-19 Identities = 62/190 (32%), Positives = 86/190 (45%), Gaps = 19/190 (10%) Query: 23 CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82 CP +C C S V C+ + P+ +PP T L L+ I +P AFR + Sbjct: 21 CPDKCYCQ-------SSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSV 73 Query: 83 GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142 L L L N+LS L GL+ L+ L L N L + P+LR LDL +N Sbjct: 74 PWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNN 133 Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNP 202 +S +P ENLT L + NQL +L + L+ S + R+L L+DN Sbjct: 134 ISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSV------------RLLLLKDNL 181 Query: 203 WACDCRLYDL 212 W C+C L L Sbjct: 182 WKCNCHLLGL 191 >gi|149773484 leucine rich repeat and fibronectin type III domain containing 1 [Homo sapiens] Length = 771 Score = 92.4 bits (228), Expect = 1e-18 Identities = 118/453 (26%), Positives = 161/453 (35%), Gaps = 94/453 (20%) Query: 11 LALAWPPQARGF-CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRL--- 66 L L W +RG CP +C C + + T++C + P +I LRL Sbjct: 21 LLLLWAGASRGQPCPGRCICQ-----NVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDN 75 Query: 67 ---------------------ERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRG 105 R I +V AF L L L L N L+E+ LRG Sbjct: 76 FIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRG 135 Query: 106 LRRLRELRLPGNR-------------------------LAAFPWAALRDAPKLRLLDLQA 140 L LR L L N+ L A PW A+ L L L Sbjct: 136 LGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDH 195 Query: 141 NRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQD 200 N + + L L LD++SN+L +LP + + + TG PP + Sbjct: 196 NLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQ-GTGPKPP---TPLTVSFGG 251 Query: 201 NPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQL--ELRKCQGPELHP 258 NP C+C L W L + CA+P L F + E C+ P L Sbjct: 252 NPLHCNCELL--------WLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCE-PPLIT 302 Query: 259 GVASIRSLL--GGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLP 316 A R+L+ G LRC A G P P + W +GR L + V DGT L + Sbjct: 303 RQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGT----LDVT 358 Query: 317 AVSHLDSGDYICQAKNFLGASETVISLIV----------TEPPTSTEHSGSPGALWARTG 366 + DSG + C A N G + + + V PP TE S A R G Sbjct: 359 ITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPG 418 Query: 367 GGGEAA--------AYNNKLVARHVPQIPKPAV 391 AA +N ++ R Q P P + Sbjct: 419 ANDSAAERRLVAAELTSNSVLIRWPAQRPVPGI 451 >gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo sapiens] Length = 593 Score = 89.4 bits (220), Expect = 9e-18 Identities = 97/334 (29%), Positives = 132/334 (39%), Gaps = 67/334 (20%) Query: 59 PDTSRLRLERTAIRRVPGEAFRPLGRLEQLWLP-YNALSELNALMLRGLRRLRELRLPGN 117 P LRL I R+P A R LG+L++L + + +L L+ L GL L L + Sbjct: 204 PALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLN-LSSLAITRC 262 Query: 118 RLAAFPWAALRDAPKLRLLDLQANRLSAVPAE---------------------AARFLEN 156 L++ P+ AL LR+LDL N +SA+PA AA Sbjct: 263 NLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHG 322 Query: 157 LT---FLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLV 213 LT LD++ N L L + S L T L L NP CDCRL L+ Sbjct: 323 LTAFHLLDVADNALQTLEETAFPSPDKLVT------------LRLSGNPLTCDCRLLWLL 370 Query: 214 HLLDGWAPNLAFIETELRCASPRSLAGVAFSQLELRKCQGPELHPGVASIRSLL------ 267 L +L F + CA P + G + + L PG + + L Sbjct: 371 RL----RRHLDFGMSPPACAGPHHVQGKSLKEFS------DILPPGHFTCKPALIRKSGP 420 Query: 268 -------GGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSH 320 GG A+ C G P P +SW R +G L V DGT L + +V Sbjct: 421 RWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLEDGT----LEIRSVQL 476 Query: 321 LDSGDYICQAKNFLG--ASETVISLIVTEPPTST 352 D G Y+C N G + T + +I EPP T Sbjct: 477 RDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGT 510 Score = 64.7 bits (156), Expect = 2e-10 Identities = 53/177 (29%), Positives = 76/177 (42%), Gaps = 9/177 (5%) Query: 7 MLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRL 66 +L+LL L P + G CP+ C C+ S+ + V+C + P +P DT L L Sbjct: 17 LLFLLLL--PGGSGGSCPAVCDCT-------SQPQAVLCGHRQLEAVPGGLPLDTELLDL 67 Query: 67 ERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAA 126 + + L L++L L YN LS L GL+ L LRL GNRL Sbjct: 68 SGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGV 127 Query: 127 LRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLET 183 L LLDL+ N++ A L +L L++ N L+ + A L T Sbjct: 128 FSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLST 184 >gi|12007646 nyctalopin precursor [Homo sapiens] Length = 481 Score = 87.8 bits (216), Expect = 3e-17 Identities = 71/197 (36%), Positives = 93/197 (47%), Gaps = 22/197 (11%) Query: 64 LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFP 123 L L+ +R V AF G LE L L N L+EL A RGLRRLR L L GN L Sbjct: 211 LSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVA 270 Query: 124 WAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLET 183 A D +L LL L N ++ V A + L L L L+ N+L +++W + Sbjct: 271 RAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRL------TVLAWVAFQP 324 Query: 184 GIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAF 243 G F L L NPW CDCRL L ++G + T++ CASP S+AG+ Sbjct: 325 GFF------LGRLFLFRNPWCCDCRLEWLRDWMEG-----SGRVTDVPCASPGSVAGLDL 373 Query: 244 SQLELRK-----CQGPE 255 SQ+ + C PE Sbjct: 374 SQVTFGRSSDGLCVDPE 390 Score = 64.7 bits (156), Expect = 2e-10 Identities = 59/170 (34%), Positives = 80/170 (47%), Gaps = 16/170 (9%) Query: 23 CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82 CP+ C+CS G +V C+ + PA +P + + L+R +R + AF L Sbjct: 31 CPAACACSTVERGC-----SVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTL 85 Query: 83 GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGN----RLAAFPWAALRDAPKLRLLDL 138 L +L L +N LS + +GL RL ELRL N L A +AAL +LR LDL Sbjct: 86 PSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAAL---SRLRRLDL 142 Query: 139 QANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQEL----IVSWAHLETG 184 A RL +VP L L L N R+P L ++ AHLE G Sbjct: 143 AACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERG 192 >gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo sapiens] Length = 370 Score = 86.7 bits (213), Expect = 6e-17 Identities = 66/218 (30%), Positives = 92/218 (42%), Gaps = 20/218 (9%) Query: 23 CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82 CP C C S++ V C+ +T P +P T L L + +P AF L Sbjct: 39 CPFSCKCD-------SRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANL 91 Query: 83 GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142 L++L L N L L + L L EL+L N + LR +P LR LDL N Sbjct: 92 SSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSING 151 Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNP 202 L+ +P L L L L SN+L L + A+L+ +L + DNP Sbjct: 152 LAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQ------------LLQVGDNP 199 Query: 203 WACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG 240 W CDC L + H ++ W +L C P+ L G Sbjct: 200 WECDCNLREFKHWME-WFSYRGGRLDQLACTLPKELRG 236 >gi|109150416 peroxidasin [Homo sapiens] Length = 1479 Score = 85.1 bits (209), Expect = 2e-16 Identities = 91/322 (28%), Positives = 125/322 (38%), Gaps = 34/322 (10%) Query: 23 CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82 CPS+C C TV C + PA + P TS L L IR + AFR L Sbjct: 36 CPSRCLCF---------RTTVRCMHLLLEAVPA-VAPQTSILDLRFNRIREIQPGAFRRL 85 Query: 83 GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142 L L L N + + + L L+ L L N + + A + L L L N+ Sbjct: 86 RNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQ 145 Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNP 202 + + ++ + L L L L +N++ HL G F +R L L N Sbjct: 146 IETLDPDSFQHLPKLERLFLHNNRI-----------THLVPGTFNHLESMKR-LRLDSNT 193 Query: 203 WACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG--VAFSQLELRKCQGPEL--HP 258 CDC + L LL +A + + C PR + G VA E C+ P + P Sbjct: 194 LHCDCEILWLADLLKTYAES-GNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEP 252 Query: 259 GVASIRSLLGGTALLRCGATGVPGPEMSWRRANGR-PLNGTVHQEVSSDGTSWTLLGLPA 317 A + S G T C A G P PE+ W R N + + DGT L + Sbjct: 253 QDADVTS--GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT----LMIQN 306 Query: 318 VSHLDSGDYICQAKNFLGASET 339 D G Y C AKN G +T Sbjct: 307 TQETDQGIYQCMAKNVAGEVKT 328 Score = 49.7 bits (117), Expect = 8e-06 Identities = 84/359 (23%), Positives = 136/359 (37%), Gaps = 57/359 (15%) Query: 63 RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122 +L L I + ++F+ L +LE+L+L N ++ L L ++ LRL N L Sbjct: 138 QLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHC- 196 Query: 123 PWAALRDAPKLRLLDL------QANRLSAVPAEAARFLENLTFLDLSSNQL-------MR 169 D L L DL N +A E R ++ + ++ +L Sbjct: 197 ------DCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITS 250 Query: 170 LPQELIVSWAHLETGIFPPGHHPR-RVLGLQDN---PWACDCRLYDLVHLLDGWAPNLAF 225 PQ+ V+ + +P+ ++ L++N D RL +LLD + Sbjct: 251 EPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRL----NLLDDGTLMIQN 306 Query: 226 I-ETE---LRCASPRSLAGVAFSQLELRKCQGPELHPGVASIRS---LLGGTALLRCGAT 278 ET+ +C + V ++ LR P V ++ L+G + L C AT Sbjct: 307 TQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSAT 366 Query: 279 GVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASE 338 G P P +SW R + PL ++ G L + V DSG+Y C A N + + Sbjct: 367 GHPPPRISWTRGDRTPLPVDPRVNITPSGG----LYIQNVVQGDSGEYACSATNNIDSVH 422 Query: 339 TVISLIVTEPPTST------------------EHSGSPGALWARTGGGGEAAAYNNKLV 379 +IV P T E G+P + A T GG + + LV Sbjct: 423 ATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLV 481 Score = 40.4 bits (93), Expect = 0.005 Identities = 40/161 (24%), Positives = 64/161 (39%), Gaps = 18/161 (11%) Query: 268 GGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYI 327 G T +C A G P P ++W + G L+ V S GT L + V+ D G Y Sbjct: 447 GQTVDFQCEAKGNPPPVIAWTKG-GSQLSVDRRHLVLSSGT----LRISGVALHDQGQYE 501 Query: 328 CQAKNFLGASETVISLIVTEPPTSTEHSGSPGALWARTGGGGEAAAYNNKLVARHVPQIP 387 CQA N +G S+ V++ + +P + + P G + + P Sbjct: 502 CQAVNIIG-SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQ--------GEP 552 Query: 388 KPAVLATGPSVPSTKEELTLEHFQMDALGELSDGRAGPSEA 428 +PA+ V T+ F + G L+ GP++A Sbjct: 553 EPAITWNKDGVQVTES----GKFHISPEGFLTINDVGPADA 589 Score = 38.9 bits (89), Expect = 0.014 Identities = 31/109 (28%), Positives = 50/109 (45%), Gaps = 11/109 (10%) Query: 254 PELHPGVASIRS----LLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTS 309 P + P ASI S +G L C + G P P ++W + +G + + +S +G Sbjct: 521 PRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNK-DGVQVTESGKFHISPEG-- 577 Query: 310 WTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSP 358 L + V D+G Y C A+N +G++ + L V P S +G P Sbjct: 578 --FLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVS--RNGDP 622 >gi|55741571 leucine rich repeat and fibronectin type III domain containing 2 [Homo sapiens] Length = 789 Score = 83.2 bits (204), Expect = 7e-16 Identities = 88/344 (25%), Positives = 126/344 (36%), Gaps = 51/344 (14%) Query: 64 LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLR------------- 110 L L R I + +F L L L L N L L LRGL L+ Sbjct: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140 Query: 111 ------------ELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLT 158 +L L N L PW ++R L L L N L + L+ L Sbjct: 141 DEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLA 200 Query: 159 FLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDG 218 LDL+SN+L +LP + I + + P P NP C+C L Sbjct: 201 RLDLTSNRLQKLPPDPIFARSQASALTATP-FAPPLSFSFGGNPLHCNCELL-------- 251 Query: 219 WAPNLAFIETELRCASPRSLAGVAFSQLELRK--CQGPELHPGVASIRSLLGGTALLRCG 276 W L + C SP L G F + + C+ P + + L G A L+C Sbjct: 252 WLRRLERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCK 311 Query: 277 ATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGA 336 A G P P + W + R + + V +GT L + + DSG + C A N G Sbjct: 312 AIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGT----LDIFITTSQDSGAFTCIAANAAGE 367 Query: 337 SETVISLIVTEPP---TSTEHSGSP--------GALWARTGGGG 369 + ++ + + + P ST + P G+ GGGG Sbjct: 368 ATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGG 411 >gi|122937309 leucine rich repeat containing 4B [Homo sapiens] Length = 713 Score = 82.0 bits (201), Expect = 1e-15 Identities = 114/454 (25%), Positives = 158/454 (34%), Gaps = 128/454 (28%) Query: 23 CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTA------------ 70 CP CSCS ++A V+C D+ PASIP +T L L+ Sbjct: 57 CPVACSCS-------NQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHL 109 Query: 71 ------------------------------------IRRVPGEAFRPLGRLEQLWLPYNA 94 + VP +AF L +L +LWL N Sbjct: 110 RHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNP 169 Query: 95 -------------------LSELNALM----------------------------LRGLR 107 L EL L L L Sbjct: 170 IESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALV 229 Query: 108 RLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQL 167 RL EL L GNRL + + LR L L +++ + A L++L L+LS N L Sbjct: 230 RLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNL 289 Query: 168 MRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIE 227 M LP +L F P H RV L NPW C+C + L L P+ Sbjct: 290 MSLPHDL-----------FTPLHRLERV-HLNHNPWHCNCDVLWLSWWLKETVPSNT--T 335 Query: 228 TELRCASPRSLAGVAFSQLELR--KCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEM 285 RC +P L G +L+ C P + + G A L+C TG + Sbjct: 336 CCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKC-RTGTSMTSV 394 Query: 286 SWRRANGRPL-NGTVHQEVS--SDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVIS 342 +W NG + +G+ +S DGT L V+ D+G Y C N G + + Sbjct: 395 NWLTPNGTLMTHGSYRVRISVLHDGT----LNFTNVTVQDTGQYTCMVTNSAGNTTASAT 450 Query: 343 LIVTE-PPTSTEHSGSPGALWARTGG-GGEAAAY 374 L V+ P + +GS G +GG GG + Y Sbjct: 451 LNVSAVDPVAAGGTGSGGGGPGGSGGVGGGSGGY 484 >gi|13194201 reticulon 4 receptor precursor [Homo sapiens] Length = 473 Score = 81.3 bits (199), Expect = 3e-15 Identities = 63/190 (33%), Positives = 82/190 (43%), Gaps = 16/190 (8%) Query: 64 LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFP 123 L L+R ++ + FR L L+ L+L NAL L R L L L L GNR+++ P Sbjct: 135 LHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVP 194 Query: 124 WAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLET 183 A R L L L NR++ V A R L L L L +N L LP E + L+ Sbjct: 195 ERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQ- 253 Query: 184 GIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAF 243 L L DNPW CDCR L W +E+ C+ P+ LAG Sbjct: 254 -----------YLRLNDNPWVCDCR----ARPLWAWLQKFRGSSSEVPCSLPQRLAGRDL 298 Query: 244 SQLELRKCQG 253 +L QG Sbjct: 299 KRLAANDLQG 308 Score = 40.0 bits (92), Expect = 0.006 Identities = 37/106 (34%), Positives = 44/106 (41%), Gaps = 6/106 (5%) Query: 63 RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122 RL L + + V AFR LGRL L+L N LS L L LR L+ LRL N Sbjct: 206 RLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN----- 260 Query: 123 PWAA-LRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQL 167 PW R P L S VP + L L++N L Sbjct: 261 PWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDL 306 Score = 33.1 bits (74), Expect = 0.78 Identities = 20/45 (44%), Positives = 23/45 (51%) Query: 138 LQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLE 182 L NR+S VPA + R NLT L L SN L R+ A LE Sbjct: 64 LHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLE 108 >gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens] Length = 347 Score = 78.6 bits (192), Expect = 2e-14 Identities = 60/177 (33%), Positives = 78/177 (44%), Gaps = 8/177 (4%) Query: 64 LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFP 123 L L +R++P L L L N L L +LRG +L L L GN+L Sbjct: 169 LDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLG 228 Query: 124 WAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLET 183 L P LR L L N+L+ V A A + L L LDLS+N L +P+ L WA L Sbjct: 229 KDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGL---WASLG- 284 Query: 184 GIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG 240 P R + NPW CD L DL L + F + + RCA P ++ G Sbjct: 285 ---QPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKM-FSQNDTRCAGPEAVKG 337 Score = 63.5 bits (153), Expect = 5e-10 Identities = 52/177 (29%), Positives = 78/177 (44%), Gaps = 10/177 (5%) Query: 7 MLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRL 66 +L L A AW G S C + GS ++ C P P +P DT L + Sbjct: 26 LLLLAASAW-----GVTLSPKDCQVFRSDHGS---SISCQPPAEI--PGYLPADTVHLAV 75 Query: 67 ERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAA 126 E + +P + +L++L L N L L+ LR + +LR L L N L P Sbjct: 76 EFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGL 135 Query: 127 LRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLET 183 + + L L L+ N+L + L+ L LDLS N+L +LP L+ ++ L T Sbjct: 136 FQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRT 192 >gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] Length = 420 Score = 78.6 bits (192), Expect = 2e-14 Identities = 64/192 (33%), Positives = 78/192 (40%), Gaps = 23/192 (11%) Query: 56 SIPPDTSR-------LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRR 108 S+ PDT + L L R + +PG FR L L+ L+L N+L L + L Sbjct: 121 SLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180 Query: 109 LRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLM 168 L L L GNRL R L L L NRL V A R L LT L L +N L Sbjct: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLA 240 Query: 169 RLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIET 228 LP E + LE L L NPWACDCR L W + Sbjct: 241 SLPGEALADLPSLE------------FLRLNANPWACDCR----ARPLWAWFQRARVSSS 284 Query: 229 ELRCASPRSLAG 240 ++ CA+P G Sbjct: 285 DVTCATPPERQG 296 Score = 68.9 bits (167), Expect = 1e-11 Identities = 59/176 (33%), Positives = 80/176 (45%), Gaps = 13/176 (7%) Query: 7 MLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRL 66 +L LLAL P A CP C+C S TV C + + P S+PP T RL L Sbjct: 18 LLMLLAL---PLAAPSCPMLCTCY-------SSPPTVSCQANNFSSVPLSLPPSTQRLFL 67 Query: 67 ERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNR-LAAFPWA 125 + IR + F L LWL N LS + R L+ L EL L NR L + Sbjct: 68 QNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPD 125 Query: 126 ALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHL 181 + +L+ L L +LS++P R L +L +L L N L+ L +L A+L Sbjct: 126 TFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANL 181 >gi|51317373 netrin-G1 ligand [Homo sapiens] Length = 640 Score = 77.8 bits (190), Expect = 3e-14 Identities = 86/316 (27%), Positives = 134/316 (42%), Gaps = 33/316 (10%) Query: 46 NDPDMTLPPASIPPDTSRLRLERTAIRR---VPGEAFRPLGRLEQLWLPYNALSELNALM 102 N+P ++P + S RL+ ++R + AF L L L L L E+ L Sbjct: 157 NNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLT 216 Query: 103 LRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDL 162 L +L EL L GN L+A + + L+ L + +++ + A L++L ++L Sbjct: 217 --PLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINL 274 Query: 163 SSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPN 222 + N L LP +L F P HH R+ L NPW C+C + L W + Sbjct: 275 AHNNLTLLPHDL-----------FTPLHHLERI-HLHHNPWNCNCDIL----WLSWWIKD 318 Query: 223 LAFIETE--LRCASPRSLAGVAFSQLELR--KCQGPELHPGVASIRSLLGGTALLRCGAT 278 +A T RC +P +L G +L+ C P + A + G A L+C A+ Sbjct: 319 MAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRAS 378 Query: 279 GVPGPEMSWRRANGRPLNGTVHQ---EVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLG 335 +SW NG + ++ V SDGT L V+ D+G Y C N +G Sbjct: 379 -TSLTSVSWITPNGTVMTHGAYKVRIAVLSDGT----LNFTNVTVQDTGMYTCMVSNSVG 433 Query: 336 ASETVISLIVTEPPTS 351 + +L VT T+ Sbjct: 434 NTTASATLNVTAATTT 449 >gi|194440719 chondroadherin-like [Homo sapiens] Length = 762 Score = 77.0 bits (188), Expect = 5e-14 Identities = 56/148 (37%), Positives = 67/148 (45%), Gaps = 7/148 (4%) Query: 23 CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82 CP C C ++R C + P P DT L L R VP AF L Sbjct: 396 CPRACVCV-------PESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGL 448 Query: 83 GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142 G L L L + ++EL A L GL RL L L N+LA AAL AP+L L L+ NR Sbjct: 449 GHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNR 508 Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRL 170 VP A R L +L L L N + RL Sbjct: 509 FLQVPGAALRALPSLFSLHLQDNAVDRL 536 Score = 66.2 bits (160), Expect = 8e-11 Identities = 57/170 (33%), Positives = 78/170 (45%), Gaps = 8/170 (4%) Query: 3 VALGMLWLLALAWPPQARGF-CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDT 61 + L +L LL LA QA CP C C D S+ R V C ++T P +IP T Sbjct: 12 LVLPLLVLLLLAPARQAAAQRCPQACIC------DNSR-RHVACRYQNLTEVPDAIPELT 64 Query: 62 SRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAA 121 RL L+ ++ +P AF+ + L L L + + + RGL RL L L N L Sbjct: 65 QRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRE 124 Query: 122 FPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLP 171 P AL LR L+L+ N L + L L L+L+ N L+ LP Sbjct: 125 LPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLP 174 Score = 65.9 bits (159), Expect = 1e-10 Identities = 68/218 (31%), Positives = 89/218 (40%), Gaps = 39/218 (17%) Query: 63 RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122 RL LE A+ + F LG L L L +NAL L A+ +GL R+R LRL N L+ Sbjct: 138 RLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVL 197 Query: 123 PWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQL--------MRLP--Q 172 AL P LR L L N L A+P L L+L N L + LP + Sbjct: 198 APEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLR 257 Query: 173 ELIV-----------SWAHL-----------ETGIFPP--GHHPRRVLGLQDNPWACDCR 208 EL++ ++AH + PP G R L LQ NP C C+ Sbjct: 258 ELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCGCQ 317 Query: 209 LYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQL 246 L+ L A + ++ C PR L G A L Sbjct: 318 ARPLLEWL-----ARARVRSDGACQGPRRLRGEALDAL 350 Score = 60.8 bits (146), Expect = 4e-09 Identities = 68/218 (31%), Positives = 85/218 (38%), Gaps = 41/218 (18%) Query: 59 PDTSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNR 118 P L LER +VPG A R L L L L NA+ L L R LR + L GNR Sbjct: 497 PRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNR 556 Query: 119 LAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLP------- 171 + AL A +L L L N+L VP A L L L LS N L L Sbjct: 557 ITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPV 616 Query: 172 ----QELIVSWAHLE-------TGIFP------------------PGHHPRRVLGLQDNP 202 Q L ++ + LE +G+ P P ++ L NP Sbjct: 617 GRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNP 676 Query: 203 WACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG 240 + CDC+L L L G NL T CA+P + G Sbjct: 677 FHCDCQLLPLHRWLTGL--NLRVGAT---CATPPNARG 709 Score = 43.5 bits (101), Expect = 6e-04 Identities = 27/66 (40%), Positives = 34/66 (51%) Query: 110 RELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMR 169 + L L GN L P AA + P L LDL+ + V A R L L L+L+SN L Sbjct: 65 QRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRE 124 Query: 170 LPQELI 175 LPQE + Sbjct: 125 LPQEAL 130 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.135 0.417 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 26,151,688 Number of Sequences: 37866 Number of extensions: 1253738 Number of successful extensions: 6690 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 254 Number of HSP's successfully gapped in prelim test: 256 Number of HSP's that attempted gapping in prelim test: 3728 Number of HSP's gapped (non-prelim): 2118 length of query: 623 length of database: 18,247,518 effective HSP length: 108 effective length of query: 515 effective length of database: 14,157,990 effective search space: 7291364850 effective search space used: 7291364850 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.