Search of human proteins with 14149694

Search of human proteins with 14149694

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14149694 retina specific protein PAL [Homo sapiens]
         (623 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14149694 retina specific protein PAL [Homo sapiens]               1256   0.0  
gi|193083136 leucine-rich repeat, immunoglobulin-like and transm...   337   3e-92
gi|62988340 leucine rich repeat containing 22 [Homo sapiens]          190   4e-48
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]         124   3e-28
gi|41582239 immunoglobulin superfamily containing leucine-rich r...   110   3e-24
gi|5031809 immunoglobulin superfamily containing leucine-rich re...   110   3e-24
gi|13375646 leucine rich repeat and fibronectin type III domain ...   106   7e-23
gi|194306623 immunoglobulin superfamily containing leucine-rich ...   105   1e-22
gi|194306621 immunoglobulin superfamily containing leucine-rich ...   105   1e-22
gi|39930401 immunoglobulin superfamily containing leucine-rich r...   105   1e-22
gi|194306618 immunoglobulin superfamily containing leucine-rich ...   105   1e-22
gi|4759146 slit homolog 2 [Homo sapiens]                              103   4e-22
gi|188528675 slit homolog 1 [Homo sapiens]                            103   5e-22
gi|27363458 leucine rich repeat and fibronectin type III domain ...   101   2e-21
gi|31542244 leucine rich repeat and fibronectin type III domain ...   100   3e-21
gi|11321571 slit homolog 3 [Homo sapiens]                              95   2e-19
gi|126517478 peroxidasin homolog-like [Homo sapiens]                   93   6e-19
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho...    93   6e-19
gi|149773484 leucine rich repeat and fibronectin type III domain...    92   1e-18
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo...    89   9e-18
gi|12007646 nyctalopin precursor [Homo sapiens]                        88   3e-17
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho...    87   6e-17
gi|109150416 peroxidasin [Homo sapiens]                                85   2e-16
gi|55741571 leucine rich repeat and fibronectin type III domain ...    83   7e-16
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]          82   1e-15
gi|13194201 reticulon 4 receptor precursor [Homo sapiens]              81   3e-15
gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]         79   2e-14
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                 79   2e-14
gi|51317373 netrin-G1 ligand [Homo sapiens]                            78   3e-14
gi|194440719 chondroadherin-like [Homo sapiens]                        77   5e-14

>gi|14149694 retina specific protein PAL [Homo sapiens]
          Length = 623

 Score = 1256 bits (3249), Expect = 0.0
 Identities = 623/623 (100%), Positives = 623/623 (100%)

Query: 1   MRVALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPD 60
           MRVALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPD
Sbjct: 1   MRVALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPD 60

Query: 61  TSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLA 120
           TSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLA
Sbjct: 61  TSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLA 120

Query: 121 AFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAH 180
           AFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAH
Sbjct: 121 AFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAH 180

Query: 181 LETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG 240
           LETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG
Sbjct: 181 LETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG 240

Query: 241 VAFSQLELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVH 300
           VAFSQLELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVH
Sbjct: 241 VAFSQLELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVH 300

Query: 301 QEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGA 360
           QEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGA
Sbjct: 301 QEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGA 360

Query: 361 LWARTGGGGEAAAYNNKLVARHVPQIPKPAVLATGPSVPSTKEELTLEHFQMDALGELSD 420
           LWARTGGGGEAAAYNNKLVARHVPQIPKPAVLATGPSVPSTKEELTLEHFQMDALGELSD
Sbjct: 361 LWARTGGGGEAAAYNNKLVARHVPQIPKPAVLATGPSVPSTKEELTLEHFQMDALGELSD 420

Query: 421 GRAGPSEARMVRSVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQHSMRRVIVQPGK 480
           GRAGPSEARMVRSVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQHSMRRVIVQPGK
Sbjct: 421 GRAGPSEARMVRSVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQHSMRRVIVQPGK 480

Query: 481 TRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFSTNEVVDAENTQQLINVVVISVAIVIA 540
           TRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFSTNEVVDAENTQQLINVVVISVAIVIA
Sbjct: 481 TRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFSTNEVVDAENTQQLINVVVISVAIVIA 540

Query: 541 LPLTLLVCCSALQKRCRKCFNKDSTEATVTYVNLERLGYSEDGLEELSRHSVSEADRLLS 600
           LPLTLLVCCSALQKRCRKCFNKDSTEATVTYVNLERLGYSEDGLEELSRHSVSEADRLLS
Sbjct: 541 LPLTLLVCCSALQKRCRKCFNKDSTEATVTYVNLERLGYSEDGLEELSRHSVSEADRLLS 600

Query: 601 ARSSVDFQAFGVKGGRRINEYFC 623
           ARSSVDFQAFGVKGGRRINEYFC
Sbjct: 601 ARSSVDFQAFGVKGGRRINEYFC 623


>gi|193083136 leucine-rich repeat, immunoglobulin-like and
           transmembrane domains 3 [Homo sapiens]
          Length = 634

 Score =  337 bits (863), Expect = 3e-92
 Identities = 212/638 (33%), Positives = 321/638 (50%), Gaps = 68/638 (10%)

Query: 49  DMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRR 108
           DM   P ++P DT +LR+E+T IRR+  EAF  L  L+ LW+ YN+++ ++      L++
Sbjct: 2   DMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQ 61

Query: 109 LRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLM 168
           L ELRL GN LAAFPWA+L D P LR LDL  N++++VP EA R+L+NL +LDLSSN+L 
Sbjct: 62  LHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLT 121

Query: 169 RLPQELIVSWAHLETGIFPPG----HHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLA 224
            LP + + SW HL +   P G       R +LGLQDNPW CDC +  ++ L     P + 
Sbjct: 122 TLPPDFLESWTHLVS--TPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIV 179

Query: 225 FIETELRCASPRSLAGVAFSQLELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPE 284
            ++  + C+ P  L G+ F + EL  C  P +      I S LG   LLRC ATG P P+
Sbjct: 180 LLDPLMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQ 239

Query: 285 MSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLI 344
           ++W R++  P+N TV QE   +G  W+++ L  +S  D+GDY C+AKN  G SE V+++ 
Sbjct: 240 ITWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVT 299

Query: 345 VTE------PPTSTEHSGSPGALWARTGGG-----GEAAAY-------NNKLVARHVPQI 386
           V        PP ++E +G       + G G       A++Y            +      
Sbjct: 300 VLGITTTPIPPDTSERTGDHPEWDVQPGSGRSTSVSSASSYLWSSSFSPTSSFSASTLSP 359

Query: 387 PKPAVLATGPSVPSTKEELTLEHFQMDALGELSDGRA------GPSEARMVR-------- 432
           P  A  +  P   ST    T     + A   +++ R+      G    ++ +        
Sbjct: 360 PSTASFSLSPFSSSTVSSTTTLSTSISASTTMANKRSFQLHQGGKRNLKVAKNGSKLPPA 419

Query: 433 ------------------------SVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQ 468
                                   +++VV +T  SV+L W      + +A +VLY+ +G 
Sbjct: 420 STSKKEELALLDQTMLTETNAAIENLRVVSETKESVTLTWNMINTTHNSAVTVLYSKYGG 479

Query: 469 HSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFSTNEVVDAENTQQLI 528
             +  +     K +VTI GL P  +Y+ACVC +G+ P+K+QC+ FST E V+ +++Q  +
Sbjct: 480 KDLLLLNADSSKNQVTIDGLEPGGQYMACVCPKGVPPQKDQCITFST-ERVEGDDSQWSL 538

Query: 529 NVVVISVAIVIALPLTLLVCCSALQKRCRKCFNKDSTEATVTYVNLERLGYSEDGLEEL- 587
            +VV S A V+ LPL   +     + +C+     +   A  TY+  E L      + EL 
Sbjct: 539 LLVVTSTACVVILPLICFLLYKVCKLQCKSEPFWEDDLAKETYIQFETLFPRSQSVGELW 598

Query: 588 -SRHSVSEADRLLSARSSVDFQ-AFGVKGGRRINEYFC 623
              H       LL +RSSV+ Q  F  +G R   EY+C
Sbjct: 599 TRSHRDDSEKLLLCSRSSVESQVTFKSEGSR--PEYYC 634


>gi|62988340 leucine rich repeat containing 22 [Homo sapiens]
          Length = 550

 Score =  190 bits (482), Expect = 4e-48
 Identities = 113/330 (34%), Positives = 168/330 (50%), Gaps = 8/330 (2%)

Query: 19  ARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEA 78
           A+ FC   C+CS    G     RT+ C    +   P ++  +  ++R+E + +  +P  +
Sbjct: 20  AQPFCLPGCTCSEESFG-----RTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGS 74

Query: 79  FRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDL 138
           F  +  LE LWL +N +S ++   L  L  LRELRL GN+L + PW A R  P LR+LDL
Sbjct: 75  FINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDL 134

Query: 139 QANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHH---PRRV 195
           + N++ A+P  A +FL +LT+LDLSSN+L  + + + ++W   +    P          V
Sbjct: 135 KRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLV 194

Query: 196 LGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQLELRKCQGPE 255
           + L DNPW CDCRL  LV  +      +  + + L C  P S AG  F + EL  C  P+
Sbjct: 195 VALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMKPQ 254

Query: 256 LHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGL 315
           +    A+I    G    LRC A   P P ++W           V    + + T+ + L +
Sbjct: 255 ISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSELAI 314

Query: 316 PAVSHLDSGDYICQAKNFLGASETVISLIV 345
           PA   +DSG+Y C A N +G S  VISL V
Sbjct: 315 PAAHLVDSGNYTCMASNSIGKSNLVISLHV 344



 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 2/126 (1%)

Query: 420 DGRAGPSEARMVRSVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQHSMRRVI-VQP 478
           D  + PSE      ++VV  T H + L W A    +   +  LY    +   + V+ + P
Sbjct: 354 DSLSIPSEGNAYIDLRVVKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEVVHIGP 413

Query: 479 GKTRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFST-NEVVDAENTQQLINVVVISVAI 537
           G     +  LLP TKY AC+ ++G  P + QCV F T  +    E  + L++V V+   +
Sbjct: 414 GINTYAVDDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTVVLCVV 473

Query: 538 VIALPL 543
           ++A+P+
Sbjct: 474 LLAVPV 479


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score =  124 bits (311), Expect = 3e-28
 Identities = 119/407 (29%), Positives = 167/407 (41%), Gaps = 70/407 (17%)

Query: 4   ALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSR 63
           A  +L LL L  P +A G CP+ C C          + TV C    + + P  IPP T  
Sbjct: 5   APALLPLLLLLLPLRAAG-CPAACRCY---------SATVECGALRLRVVPLGIPPGTQT 54

Query: 64  LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLR------------------- 104
           L L+   I R+   A  PL  L +L+L  N+L  L A   R                   
Sbjct: 55  LFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLR 114

Query: 105 -----GLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTF 159
                GL +LR L L GN+LA          P+L+ L LQ N +  +  +A   L +L  
Sbjct: 115 SGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLAL 174

Query: 160 LDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDL-VHLLDG 218
           LDLS NQL  + +E +   A L+            VL L +NPW CDC L+ L   + +G
Sbjct: 175 LDLSRNQLGTISREALQPLASLQ------------VLRLTENPWRCDCALHWLGAWIKEG 222

Query: 219 WAPNLAFIETELRCASP-----RSLAGVAFSQLELRKCQGPELHPGVASIRSLLGGTALL 273
               L   + ++ CA P     +SL  V+ S L    C  P +H     + + LG    +
Sbjct: 223 GQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSL---ICIPPSVHVQPLELTANLGEDLRV 279

Query: 274 RCGATGVPGPEMSWRRA----NGRP---------LNGTVHQEVSSDGTSWTLLGLPAVSH 320
            C A+G P P ++WR+      GRP         L G      S  G+    L    ++H
Sbjct: 280 ACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAH 339

Query: 321 LDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGALWARTGG 367
             +G Y C+A N  GA+     L+V       +    P    AR  G
Sbjct: 340 --AGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPPPAARPAG 384


>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score =  110 bits (276), Expect = 3e-24
 Identities = 98/372 (26%), Positives = 146/372 (39%), Gaps = 56/372 (15%)

Query: 5   LGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRL 64
           L +LW   L    QA   CP  C C     G+    +   C   D+   P   P + + L
Sbjct: 4   LHLLWWALLLGLAQA---CPEPCDC-----GEKYGFQIADCAYRDLESVPPGFPANVTTL 55

Query: 65  RLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPW 124
            L    +  +P  AFR +  L+ LWL +N +  + A  L  L  L+ L L  N ++ F W
Sbjct: 56  SLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAW 115

Query: 125 AALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETG 184
           + L +   L+LL + +N L+ +P +A R L  L  L L+ N+L  L +           G
Sbjct: 116 SDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAE-----------G 164

Query: 185 IFPP----GHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFI---ETELRCASPRS 237
            F P     H     L + +NP+ C C +      L  WA   A     +  + C SP  
Sbjct: 165 TFTPLTALSH-----LQINENPFDCTCGIV----WLKTWALTTAVSIPEQDNIACTSPHV 215

Query: 238 LAGVAFSQLELRKCQGPEL----HPGVASIRSLLGGTALLRCGATGVPGPEMSWR----- 288
           L G   S+L    C  P +     P         G    L C   G P P++ W      
Sbjct: 216 LKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPS 275

Query: 289 ----------RANGRPLNGT--VHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGA 336
                       +GR L GT     +      +   L +P    L+ G Y C A N LG+
Sbjct: 276 GIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGS 335

Query: 337 SETVISLIVTEP 348
           +E+ + + +  P
Sbjct: 336 AESSVDVALATP 347


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score =  110 bits (276), Expect = 3e-24
 Identities = 98/372 (26%), Positives = 146/372 (39%), Gaps = 56/372 (15%)

Query: 5   LGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRL 64
           L +LW   L    QA   CP  C C     G+    +   C   D+   P   P + + L
Sbjct: 4   LHLLWWALLLGLAQA---CPEPCDC-----GEKYGFQIADCAYRDLESVPPGFPANVTTL 55

Query: 65  RLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPW 124
            L    +  +P  AFR +  L+ LWL +N +  + A  L  L  L+ L L  N ++ F W
Sbjct: 56  SLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAW 115

Query: 125 AALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETG 184
           + L +   L+LL + +N L+ +P +A R L  L  L L+ N+L  L +           G
Sbjct: 116 SDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAE-----------G 164

Query: 185 IFPP----GHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFI---ETELRCASPRS 237
            F P     H     L + +NP+ C C +      L  WA   A     +  + C SP  
Sbjct: 165 TFTPLTALSH-----LQINENPFDCTCGIV----WLKTWALTTAVSIPEQDNIACTSPHV 215

Query: 238 LAGVAFSQLELRKCQGPEL----HPGVASIRSLLGGTALLRCGATGVPGPEMSWR----- 288
           L G   S+L    C  P +     P         G    L C   G P P++ W      
Sbjct: 216 LKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPS 275

Query: 289 ----------RANGRPLNGT--VHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGA 336
                       +GR L GT     +      +   L +P    L+ G Y C A N LG+
Sbjct: 276 GIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGS 335

Query: 337 SETVISLIVTEP 348
           +E+ + + +  P
Sbjct: 336 AESSVDVALATP 347


>gi|13375646 leucine rich repeat and fibronectin type III domain
           containing 3 [Homo sapiens]
          Length = 628

 Score =  106 bits (264), Expect = 7e-23
 Identities = 116/401 (28%), Positives = 150/401 (37%), Gaps = 78/401 (19%)

Query: 7   MLWLLALA---WPPQAR--GFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDT 61
           +L LL LA    PPQ+     CP +C C        S   +V+C    +   P S+    
Sbjct: 7   LLCLLPLAPASSPPQSATPSPCPRRCRCQTQ-----SLPLSVLCPGAGLLFVPPSLDRRA 61

Query: 62  SRLRL------------------------ERTAIRRVPGEAFRPLGRLEQLWLPYNALSE 97
           + LRL                         R  IR V   AF  L  L  L L  N L+ 
Sbjct: 62  AELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTS 121

Query: 98  LNALMLRGLRRLRELRLPGNRLAAF-------------------------PWAALRDAPK 132
           L    LRGL  LR L L  N+LAA                          PW AL     
Sbjct: 122 LGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGN 181

Query: 133 LRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHP 192
           +  L L  N L++VPA A   L  L  LD++SN+L  +P + + S   L   +  P   P
Sbjct: 182 VNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPL---LARPRGSP 238

Query: 193 RR--VLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQL--EL 248
               VL    NP  C+C L         W   LA  +    CASP +L G  F  +  E 
Sbjct: 239 ASALVLAFGGNPLHCNCELV--------WLRRLAREDDLEACASPPALGGRYFWAVGEEE 290

Query: 249 RKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGT 308
             C+ P +      +    G  A LRC A G P P + W    GR L  +       +GT
Sbjct: 291 FVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGT 350

Query: 309 SWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPP 349
              L+  P     D G + C A N  G +   + L V  PP
Sbjct: 351 LELLVTEPG----DGGIFTCIAANAAGEATAAVELTVGPPP 387


>gi|194306623 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  105 bits (262), Expect = 1e-22
 Identities = 155/655 (23%), Positives = 244/655 (37%), Gaps = 145/655 (22%)

Query: 4   ALGMLW-LLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTS 62
           AL ++W LL +A      G CP  C+C      D    +   C   ++   P  +P + +
Sbjct: 6   ALWLVWALLGVA------GSCPEPCACV-----DKYAHQFADCAYKELREVPEGLPANVT 54

Query: 63  RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122
            L L    I  +   AF  + ++  LWL +N +  +    L  L +L+ L L  N +++F
Sbjct: 55  TLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSF 114

Query: 123 PWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQ---ELIVSWA 179
           PW+ LR+   L+LL +  NRL ++P +A   L +L  L +++N+L  L     + + + +
Sbjct: 115 PWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALS 174

Query: 180 HLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETE---LRCASPR 236
           HL+               L  NP+ C C L      L  WA +      E   + CASP 
Sbjct: 175 HLQ---------------LYHNPFHCGCGLV----WLQAWAASTRVSLPEPDSIACASPP 215

Query: 237 SLAGVAFSQLELRKCQGPELH-----PGVASIRSLLGGTA-LLRCGATGVPGPEMSWR-- 288
           +L GV   +L    C  P +H     P  A    L  G A +L C A G P P + W+  
Sbjct: 216 ALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQ 275

Query: 289 ---------------------------RANGRPLNGTVHQEVSSDGTSWTL--------- 312
                                        +G  L  T   +  +   +W           
Sbjct: 276 IPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQT-QAQTPTPAPAWPAPPATPRFLA 334

Query: 313 -----LGLPAVSHLDSGDYICQAKNFLGASETVISLIV--TEPPTSTEHSGSPGALWART 365
                L +P +S  ++G Y C+A N LGA+ T I + V  T PP     +G      A T
Sbjct: 335 LANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPT 394

Query: 366 GGGGEAAAYNNKLVARHVPQ-------IPKPAVLA---TGPSVPSTKEELTLEHFQMDAL 415
                 A      V    P+       + K ++L    T P   +++ E   +    D  
Sbjct: 395 SERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETETEPEEDTSEGEEAEDQILADPA 454

Query: 416 GELSDGRAGPS----------EARMVRSVKVVG----DTYHSVSLVWKAPQA-------- 453
            E   G   PS           A +   V  +G    D     + V   P A        
Sbjct: 455 EEQRCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPG 514

Query: 454 ---------KNTTAFSVLYAVFGQHSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLV 504
                    +       L    G  +++   V+ G       GL P T Y  C+ + G  
Sbjct: 515 GAGGAPRPGRRPLRLLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAG-- 572

Query: 505 PRKEQC---VIFSTNEVVDAENTQQLINVVVISVAIVI--ALPLTLLVCCSALQK 554
              E C   V+FST + + +     L+ +V +SV +++   +PL    CC  L K
Sbjct: 573 ---EACHVQVVFSTKKELPS-----LLVIVAVSVFLLVLATVPLLGAACCHLLAK 619


>gi|194306621 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  105 bits (262), Expect = 1e-22
 Identities = 155/655 (23%), Positives = 244/655 (37%), Gaps = 145/655 (22%)

Query: 4   ALGMLW-LLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTS 62
           AL ++W LL +A      G CP  C+C      D    +   C   ++   P  +P + +
Sbjct: 6   ALWLVWALLGVA------GSCPEPCACV-----DKYAHQFADCAYKELREVPEGLPANVT 54

Query: 63  RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122
            L L    I  +   AF  + ++  LWL +N +  +    L  L +L+ L L  N +++F
Sbjct: 55  TLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSF 114

Query: 123 PWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQ---ELIVSWA 179
           PW+ LR+   L+LL +  NRL ++P +A   L +L  L +++N+L  L     + + + +
Sbjct: 115 PWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALS 174

Query: 180 HLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETE---LRCASPR 236
           HL+               L  NP+ C C L      L  WA +      E   + CASP 
Sbjct: 175 HLQ---------------LYHNPFHCGCGLV----WLQAWAASTRVSLPEPDSIACASPP 215

Query: 237 SLAGVAFSQLELRKCQGPELH-----PGVASIRSLLGGTA-LLRCGATGVPGPEMSWR-- 288
           +L GV   +L    C  P +H     P  A    L  G A +L C A G P P + W+  
Sbjct: 216 ALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQ 275

Query: 289 ---------------------------RANGRPLNGTVHQEVSSDGTSWTL--------- 312
                                        +G  L  T   +  +   +W           
Sbjct: 276 IPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQT-QAQTPTPAPAWPAPPATPRFLA 334

Query: 313 -----LGLPAVSHLDSGDYICQAKNFLGASETVISLIV--TEPPTSTEHSGSPGALWART 365
                L +P +S  ++G Y C+A N LGA+ T I + V  T PP     +G      A T
Sbjct: 335 LANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPT 394

Query: 366 GGGGEAAAYNNKLVARHVPQ-------IPKPAVLA---TGPSVPSTKEELTLEHFQMDAL 415
                 A      V    P+       + K ++L    T P   +++ E   +    D  
Sbjct: 395 SERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETETEPEEDTSEGEEAEDQILADPA 454

Query: 416 GELSDGRAGPS----------EARMVRSVKVVG----DTYHSVSLVWKAPQA-------- 453
            E   G   PS           A +   V  +G    D     + V   P A        
Sbjct: 455 EEQRCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPG 514

Query: 454 ---------KNTTAFSVLYAVFGQHSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLV 504
                    +       L    G  +++   V+ G       GL P T Y  C+ + G  
Sbjct: 515 GAGGAPRPGRRPLRLLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAG-- 572

Query: 505 PRKEQC---VIFSTNEVVDAENTQQLINVVVISVAIVI--ALPLTLLVCCSALQK 554
              E C   V+FST + + +     L+ +V +SV +++   +PL    CC  L K
Sbjct: 573 ---EACHVQVVFSTKKELPS-----LLVIVAVSVFLLVLATVPLLGAACCHLLAK 619


>gi|39930401 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  105 bits (262), Expect = 1e-22
 Identities = 155/655 (23%), Positives = 244/655 (37%), Gaps = 145/655 (22%)

Query: 4   ALGMLW-LLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTS 62
           AL ++W LL +A      G CP  C+C      D    +   C   ++   P  +P + +
Sbjct: 6   ALWLVWALLGVA------GSCPEPCACV-----DKYAHQFADCAYKELREVPEGLPANVT 54

Query: 63  RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122
            L L    I  +   AF  + ++  LWL +N +  +    L  L +L+ L L  N +++F
Sbjct: 55  TLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSF 114

Query: 123 PWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQ---ELIVSWA 179
           PW+ LR+   L+LL +  NRL ++P +A   L +L  L +++N+L  L     + + + +
Sbjct: 115 PWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALS 174

Query: 180 HLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETE---LRCASPR 236
           HL+               L  NP+ C C L      L  WA +      E   + CASP 
Sbjct: 175 HLQ---------------LYHNPFHCGCGLV----WLQAWAASTRVSLPEPDSIACASPP 215

Query: 237 SLAGVAFSQLELRKCQGPELH-----PGVASIRSLLGGTA-LLRCGATGVPGPEMSWR-- 288
           +L GV   +L    C  P +H     P  A    L  G A +L C A G P P + W+  
Sbjct: 216 ALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQ 275

Query: 289 ---------------------------RANGRPLNGTVHQEVSSDGTSWTL--------- 312
                                        +G  L  T   +  +   +W           
Sbjct: 276 IPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQT-QAQTPTPAPAWPAPPATPRFLA 334

Query: 313 -----LGLPAVSHLDSGDYICQAKNFLGASETVISLIV--TEPPTSTEHSGSPGALWART 365
                L +P +S  ++G Y C+A N LGA+ T I + V  T PP     +G      A T
Sbjct: 335 LANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPT 394

Query: 366 GGGGEAAAYNNKLVARHVPQ-------IPKPAVLA---TGPSVPSTKEELTLEHFQMDAL 415
                 A      V    P+       + K ++L    T P   +++ E   +    D  
Sbjct: 395 SERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETETEPEEDTSEGEEAEDQILADPA 454

Query: 416 GELSDGRAGPS----------EARMVRSVKVVG----DTYHSVSLVWKAPQA-------- 453
            E   G   PS           A +   V  +G    D     + V   P A        
Sbjct: 455 EEQRCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPG 514

Query: 454 ---------KNTTAFSVLYAVFGQHSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLV 504
                    +       L    G  +++   V+ G       GL P T Y  C+ + G  
Sbjct: 515 GAGGAPRPGRRPLRLLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAG-- 572

Query: 505 PRKEQC---VIFSTNEVVDAENTQQLINVVVISVAIVI--ALPLTLLVCCSALQK 554
              E C   V+FST + + +     L+ +V +SV +++   +PL    CC  L K
Sbjct: 573 ---EACHVQVVFSTKKELPS-----LLVIVAVSVFLLVLATVPLLGAACCHLLAK 619


>gi|194306618 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  105 bits (262), Expect = 1e-22
 Identities = 155/655 (23%), Positives = 244/655 (37%), Gaps = 145/655 (22%)

Query: 4   ALGMLW-LLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTS 62
           AL ++W LL +A      G CP  C+C      D    +   C   ++   P  +P + +
Sbjct: 6   ALWLVWALLGVA------GSCPEPCACV-----DKYAHQFADCAYKELREVPEGLPANVT 54

Query: 63  RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122
            L L    I  +   AF  + ++  LWL +N +  +    L  L +L+ L L  N +++F
Sbjct: 55  TLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSF 114

Query: 123 PWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQ---ELIVSWA 179
           PW+ LR+   L+LL +  NRL ++P +A   L +L  L +++N+L  L     + + + +
Sbjct: 115 PWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALS 174

Query: 180 HLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETE---LRCASPR 236
           HL+               L  NP+ C C L      L  WA +      E   + CASP 
Sbjct: 175 HLQ---------------LYHNPFHCGCGLV----WLQAWAASTRVSLPEPDSIACASPP 215

Query: 237 SLAGVAFSQLELRKCQGPELH-----PGVASIRSLLGGTA-LLRCGATGVPGPEMSWR-- 288
           +L GV   +L    C  P +H     P  A    L  G A +L C A G P P + W+  
Sbjct: 216 ALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQ 275

Query: 289 ---------------------------RANGRPLNGTVHQEVSSDGTSWTL--------- 312
                                        +G  L  T   +  +   +W           
Sbjct: 276 IPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQT-QAQTPTPAPAWPAPPATPRFLA 334

Query: 313 -----LGLPAVSHLDSGDYICQAKNFLGASETVISLIV--TEPPTSTEHSGSPGALWART 365
                L +P +S  ++G Y C+A N LGA+ T I + V  T PP     +G      A T
Sbjct: 335 LANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPT 394

Query: 366 GGGGEAAAYNNKLVARHVPQ-------IPKPAVLA---TGPSVPSTKEELTLEHFQMDAL 415
                 A      V    P+       + K ++L    T P   +++ E   +    D  
Sbjct: 395 SERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETETEPEEDTSEGEEAEDQILADPA 454

Query: 416 GELSDGRAGPS----------EARMVRSVKVVG----DTYHSVSLVWKAPQA-------- 453
            E   G   PS           A +   V  +G    D     + V   P A        
Sbjct: 455 EEQRCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPG 514

Query: 454 ---------KNTTAFSVLYAVFGQHSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLV 504
                    +       L    G  +++   V+ G       GL P T Y  C+ + G  
Sbjct: 515 GAGGAPRPGRRPLRLLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAG-- 572

Query: 505 PRKEQC---VIFSTNEVVDAENTQQLINVVVISVAIVI--ALPLTLLVCCSALQK 554
              E C   V+FST + + +     L+ +V +SV +++   +PL    CC  L K
Sbjct: 573 ---EACHVQVVFSTKKELPS-----LLVIVAVSVFLLVLATVPLLGAACCHLLAK 619


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score =  103 bits (258), Expect = 4e-22
 Identities = 80/252 (31%), Positives = 117/252 (46%), Gaps = 31/252 (12%)

Query: 23  CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82
           CP+ C+CS +I         V C    +T  P ++P   + +RLE+  I+ +P  AF P 
Sbjct: 273 CPAACTCSNNI---------VDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPY 323

Query: 83  GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142
            +L ++ L  N +SEL     +GLR L  L L GN++   P +       L+LL L AN+
Sbjct: 324 KKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANK 383

Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNP 202
           ++ +  +A + L NL  L L  N+L  + +           G F P     + + L  NP
Sbjct: 384 INCLRVDAFQDLHNLNLLSLYDNKLQTIAK-----------GTFSP-LRAIQTMHLAQNP 431

Query: 203 WACDCRLYDLVHLLDGWAPNLAFIETE-LRCASPRSLAGVAFSQLELRK--CQGPELH-- 257
           + CDC L  L   L     +   IET   RC SPR LA     Q++ +K  C   E +  
Sbjct: 432 FICDCHLKWLADYL-----HTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFI 486

Query: 258 PGVASIRSLLGG 269
           PG    RS L G
Sbjct: 487 PGTEDYRSKLSG 498



 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 74/267 (27%), Positives = 108/267 (40%), Gaps = 30/267 (11%)

Query: 1   MRVALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPD 60
           + ++LG++  +     PQA   CP+QCSCS           TV C+   +   P +IP +
Sbjct: 9   LSLSLGLVLAILNKVAPQA---CPAQCSCS---------GSTVDCHGLALRSVPRNIPRN 56

Query: 61  TSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLA 120
           T RL L    I R+    F  L  L  L L  N +S +     + L+ L  LRL  N L 
Sbjct: 57  TERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQ 116

Query: 121 AFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAH 180
            FP        KL  LDL  N++ A+P +A R   ++  L L  NQ+  +      +   
Sbjct: 117 LFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRD 176

Query: 181 LET-----------GIFPPGHHPR-RVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIET 228
           LE             +    H P+ R   L  N   CDC L      L  W      +  
Sbjct: 177 LEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHL----AWLSDWLRQRPRVGL 232

Query: 229 ELRCASPRSLAGVAFSQLELRK--CQG 253
             +C  P  L G   ++++ R+  C G
Sbjct: 233 YTQCMGPSHLRGHNVAEVQKREFVCSG 259



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 26/228 (11%)

Query: 23  CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEA-FRP 81
           CP +C C         +  TV C++  +   P  IP  T+ LRL       +     F+ 
Sbjct: 506 CPEKCRC---------EGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKK 556

Query: 82  LGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQAN 141
           L +L ++    N ++++      G   + E+ L  NRL        +    L+ L L++N
Sbjct: 557 LPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSN 616

Query: 142 RLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDN 201
           R++ V         N +F+ LSS +L+ L    I + A    G F    H    L L  N
Sbjct: 617 RITCV--------GNDSFIGLSSVRLLSLYDNQITTVA---PGAFDT-LHSLSTLNLLAN 664

Query: 202 PWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQLELR 249
           P+ C+C L      L  W      +    RC  P  L  +    + ++
Sbjct: 665 PFNCNCYL----AWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQ 708



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 63/235 (26%), Positives = 84/235 (35%), Gaps = 54/235 (22%)

Query: 23  CPSQCSCSLHIMGDGSKARTVV-CNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRP 81
           CP++C+C            TVV C++  + + P  IP D + L L+      VP E    
Sbjct: 727 CPTECTC----------LDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSN- 775

Query: 82  LGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQAN 141
              L  + L  N +S L+      + +L  L L  NRL   P         LRLL L  N
Sbjct: 776 YKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGN 835

Query: 142 RLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDN 201
            +S VP  A        F DLS             + +HL  G                N
Sbjct: 836 DISVVPEGA--------FNDLS-------------ALSHLAIGA---------------N 859

Query: 202 PWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQLELRK--CQGP 254
           P  CDC +      L  W  +        RCA P  +A         +K  CQGP
Sbjct: 860 PLYCDCNM----QWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGP 910


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  103 bits (257), Expect = 5e-22
 Identities = 73/231 (31%), Positives = 109/231 (47%), Gaps = 27/231 (11%)

Query: 21  GFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFR 80
           G CP+ C+CS  I         V C    +T  PA++P   + +RLE   I+ +P  AF 
Sbjct: 280 GSCPAMCTCSNGI---------VDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFS 330

Query: 81  PLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQA 140
           P  +L ++ L  N ++E+     +GLR L  L L GN++   P         L+LL L A
Sbjct: 331 PYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNA 390

Query: 141 NRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQD 200
           N+++ +  +A + L+NL+ L L  N++  L +    S   ++T            L L  
Sbjct: 391 NKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQT------------LHLAQ 438

Query: 201 NPWACDCRLYDLVHLLDGWAPNLAFIETE-LRCASPRSLAGVAFSQLELRK 250
           NP+ CDC L  L   L         IET   RCASPR LA     Q++ +K
Sbjct: 439 NPFICDCNLKWLADFL-----RTNPIETSGARCASPRRLANKRIGQIKSKK 484



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 70/254 (27%), Positives = 103/254 (40%), Gaps = 28/254 (11%)

Query: 8   LWLL--ALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLR 65
           LWLL  A AW   A   CP+ C+C+           TV C+   +   P +IP +T RL 
Sbjct: 18  LWLLLWAAAWRLGASA-CPALCTCT---------GTTVDCHGTGLQAIPKNIPRNTERLE 67

Query: 66  LERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWA 125
           L    I R+    F  L +L  L L  N +  +       ++ L  LRL  N+L   P  
Sbjct: 68  LNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPEL 127

Query: 126 ALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLET-- 183
             ++   L  LDL  N + A+P +A R   +L  L L  NQ+  + +    +   LE   
Sbjct: 128 LFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLT 187

Query: 184 ---------GIFPPGHHPR-RVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCA 233
                     +    H P+ R   L  N   CDC L      L  W      I    +C+
Sbjct: 188 LNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHL----AWLSQWLRQRPTIGLFTQCS 243

Query: 234 SPRSLAGVAFSQLE 247
            P SL G+  ++++
Sbjct: 244 GPASLRGLNVAEVQ 257



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 58/214 (27%), Positives = 87/214 (40%), Gaps = 26/214 (12%)

Query: 23  CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEA-FRP 81
           CP +C C         +A  V C+   +T  P  IP  T+ LRL    I  +     F+ 
Sbjct: 513 CPHKCRC---------EANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKK 563

Query: 82  LGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQAN 141
           L  L+++ L  N +SE+      G   + EL L  N+L +      R    LR L L+ N
Sbjct: 564 LTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNN 623

Query: 142 RLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDN 201
           R+S +  ++   L N+  L L  NQ+  +      +   L T            L L  N
Sbjct: 624 RISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLST------------LNLLAN 671

Query: 202 PWACDCRLYDLVHLLDGWAPNLAFIETELRCASP 235
           P+ C+C+L      L GW      +    RC +P
Sbjct: 672 PFNCNCQL----AWLGGWLRKRKIVTGNPRCQNP 701



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 40/145 (27%), Positives = 57/145 (39%), Gaps = 34/145 (23%)

Query: 23  CPSQCSCSLHIMGDGSKARTVV-CNDPDMTLPPASIPPDTSRLRLERTAIRRVPGE---- 77
           CP +C+C            TVV C++  +   P  IP + + L L+      VPG+    
Sbjct: 734 CPQECAC----------LDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTF 783

Query: 78  -------------------AFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNR 118
                              +F  + +L  L L YNAL  +  L  +GLR LR L L GN 
Sbjct: 784 KYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGND 843

Query: 119 LAAFPWAALRDAPKLRLLDLQANRL 143
           ++        D   L  L + AN L
Sbjct: 844 ISTLQEGIFADVTSLSHLAIGANPL 868


>gi|27363458 leucine rich repeat and fibronectin type III domain
           containing 4 [Homo sapiens]
          Length = 635

 Score =  101 bits (252), Expect = 2e-21
 Identities = 111/373 (29%), Positives = 143/373 (38%), Gaps = 56/373 (15%)

Query: 64  LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF- 122
           L L R AI R+   AF  L  L  L L  N L EL    LRG   L+ L L GN+L    
Sbjct: 77  LTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQHLILSGNQLGRIA 136

Query: 123 ------------------------PWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLT 158
                                   PWA +   P L  L+L  N + A+P  A   L  L+
Sbjct: 137 PGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLS 196

Query: 159 FLDLSSNQLMRL-PQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLD 217
            LDL+SN+L  L P  L       E    P       VL    NP  C+C L        
Sbjct: 197 RLDLTSNRLATLAPDPLFSRGRDAEASPAP------LVLSFSGNPLHCNCELL------- 243

Query: 218 GWAPNLAFIETELRCASPRSLAGVAFSQLELRK--CQGPELHPGVASIRSLLGGTALLRC 275
            W   LA  +    CASP  LAG  F  +   +  C+ P +      +  L G  A LRC
Sbjct: 244 -WLRRLARPDDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQRLWVLEGQRATLRC 302

Query: 276 GATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLG 335
            A G P P M W   + R +  +       +GT    L +      D+G Y C A N  G
Sbjct: 303 RALGDPAPTMHWVGPDDRLVGNSSRARAFPNGT----LEIGVTGAGDAGGYTCIATNPAG 358

Query: 336 ASETVISLIVTEPP---TSTEHSGSPG----ALWARTGGGGEAAAYNNKLVARHVPQIPK 388
            +   + L V   P    S+   G PG    A  ART   GE    +   V   V ++  
Sbjct: 359 EATARVELRVLALPHGGNSSAEGGRPGPSDIAASARTAAEGEGTLESEPAV--QVTEVTA 416

Query: 389 PAVLAT-GPSVPS 400
            + L + GP  P+
Sbjct: 417 TSGLVSWGPGRPA 429


>gi|31542244 leucine rich repeat and fibronectin type III domain
           containing 5 [Homo sapiens]
          Length = 719

 Score =  100 bits (250), Expect = 3e-21
 Identities = 83/302 (27%), Positives = 125/302 (41%), Gaps = 22/302 (7%)

Query: 64  LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFP 123
           L L    + ++  + F  L  L  L L  N L+ +++     +  L EL L  N L   P
Sbjct: 104 LHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIP 163

Query: 124 WAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHL-- 181
           W A+     L  L L  N +  +P      L  +T LD++SN+L +LP + +   A +  
Sbjct: 164 WDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLA 223

Query: 182 ETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGV 241
            +GI  P       L    NP  C+C L         W   L+  +    CASP  L G 
Sbjct: 224 TSGIISPSTF---ALSFGGNPLHCNCELL--------WLRRLSREDDLETCASPPLLTGR 272

Query: 242 AFSQL--ELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTV 299
            F  +  E   C+ P +      +R L G  A LRC A G P P + W    G+ ++   
Sbjct: 273 YFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNAT 332

Query: 300 HQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPP---TSTEHSG 356
              V  +GT    L +   +  D+G + C A N  G +  ++ L + + P    ST H  
Sbjct: 333 RSLVYDNGT----LDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNSTNHIH 388

Query: 357 SP 358
            P
Sbjct: 389 EP 390


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 70/236 (29%), Positives = 109/236 (46%), Gaps = 29/236 (12%)

Query: 23  CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82
           CPS C+CS +I         V C    +   PA++P     +RLE+ +I+ +P  AF   
Sbjct: 280 CPSPCTCSNNI---------VDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQY 330

Query: 83  GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142
            +L+++ +  N +S++     +GL+ L  L L GN++             L+LL L AN+
Sbjct: 331 KKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANK 390

Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNP 202
           ++ +     + L+NL  L L  N+L  + + L      ++T            L L  NP
Sbjct: 391 INCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQT------------LHLAQNP 438

Query: 203 WACDCRLYDLVHLLDGWAPNLAFIETE-LRCASPRSLAGVAFSQLELRK--CQGPE 255
           + CDC L  L   L         IET   RC+SPR LA    SQ++ +K  C G E
Sbjct: 439 FVCDCHLKWLADYLQDNP-----IETSGARCSSPRRLANKRISQIKSKKFRCSGSE 489



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 73/279 (26%), Positives = 114/279 (40%), Gaps = 29/279 (10%)

Query: 2   RVALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDT 61
           R+AL +     L+ PP     CP++C+CS         A +V C+   +   P  IP + 
Sbjct: 15  RLALALALASVLSGPPAVA--CPTKCTCS---------AASVDCHGLGLRAVPRGIPRNA 63

Query: 62  SRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAA 121
            RL L+R  I R+    F  L  L  L L  N +S +     + L++L  LRL  N+L  
Sbjct: 64  ERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQV 123

Query: 122 FPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHL 181
            P    +  PKL  LDL  N++  +P +A R + ++  L L +N +  +      +   L
Sbjct: 124 LPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDL 183

Query: 182 E-----------TGIFPPGHHPR-RVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETE 229
           E             +    H P+ R L L  N   CDC L      L  W      +   
Sbjct: 184 EILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHL----AWLSDWLRQRRTVGQF 239

Query: 230 LRCASPRSLAGVAFSQLELRK--CQGPELHPGVASIRSL 266
             C +P  L G   + ++ ++  C  P   P   +  S+
Sbjct: 240 TLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSI 278



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 46/146 (31%), Positives = 64/146 (43%), Gaps = 12/146 (8%)

Query: 23  CPSQCSCSLHIMGDGSKARTVV-CNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRP 81
           CP QC+C            TVV C++  +   P  +P D + L LE   +  VP E    
Sbjct: 725 CPEQCTCM----------ETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRE-LSA 773

Query: 82  LGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQAN 141
           L  L  + L  N++S L       +  L  L L  NRL   P  A      LR+L L  N
Sbjct: 774 LRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGN 833

Query: 142 RLSAVPAEAARFLENLTFLDLSSNQL 167
            +S+VP  +   L +L+ L L +N L
Sbjct: 834 DISSVPEGSFNDLTSLSHLALGTNPL 859



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 29/107 (27%), Positives = 49/107 (45%)

Query: 59  PDTSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNR 118
           P+  ++ L    I+ V   AF     +++L L  N L  ++  + RGL  L+ L L  N 
Sbjct: 557 PNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNL 616

Query: 119 LAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSN 165
           +             +RLL L  NR++ +   A   L +L+ ++L SN
Sbjct: 617 IGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSN 663



 Score = 36.2 bits (82), Expect = 0.093
 Identities = 46/161 (28%), Positives = 63/161 (39%), Gaps = 25/161 (15%)

Query: 112 LRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLP 171
           +R     L A P    +D  +L L   + N L+AVP E +  L +LT +DLS+N +  L 
Sbjct: 736 VRCSNKGLRALPRGMPKDVTELYL---EGNHLTAVPRELSA-LRHLTLIDLSNNSISMLT 791

Query: 172 QELIVSWAHLETGIFP------------PGHHPRRVLGLQDN-----PWACDCRLYDLVH 214
                + +HL T I               G    RVL L  N     P      L  L H
Sbjct: 792 NYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSH 851

Query: 215 LLDGWAPNLAFIETELRCASPRSLAGVAFSQLELRKCQGPE 255
           L  G  P     +  LR  S    AG  + +  + +C  PE
Sbjct: 852 LALGTNP--LHCDCSLRWLSEWVKAG--YKEPGIARCSSPE 888


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 92/325 (28%), Positives = 131/325 (40%), Gaps = 30/325 (9%)

Query: 23  CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82
           CPS+C C            TV C    +   P  +P  T+ L L    IR +PG AF+ L
Sbjct: 24  CPSRCLCF---------KSTVRCMHLMLDHIP-QVPQQTTVLDLRFNRIREIPGSAFKKL 73

Query: 83  GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142
             L  L L  N + +++     GL  L  L L  N + A      +    L  L +  N+
Sbjct: 74  KNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQ 133

Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNP 202
           L  +  E    L  L  L L +N+L ++P     S+++L++          + L L  N 
Sbjct: 134 LEMLQPETFGDLLRLERLFLHNNKLSKIPAG---SFSNLDS---------LKRLRLDSNA 181

Query: 203 WACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG--VAFSQLELRKCQGPELHPGV 260
             CDC L  L  LL G+A +    +    C  PR L G  VA   +E   CQ P +    
Sbjct: 182 LVCDCDLMWLGELLQGFAQH-GHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEP 240

Query: 261 ASIRSLLGGTALLRCGATGVPGPEMSWRRAN-GRPLNGTVHQEVSSDGTSWTLLGLPAVS 319
             +    G T    C A G P PE+ W   N    L       V  DGT    L +    
Sbjct: 241 QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGT----LMIRNTR 296

Query: 320 HLDSGDYICQAKNFLGASETVISLI 344
             D G Y C A+N  G ++T  +++
Sbjct: 297 ESDQGVYQCMARNSAGEAKTQSAML 321



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 38/122 (31%), Positives = 53/122 (43%), Gaps = 26/122 (21%)

Query: 266 LLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGD 325
           L+G +  L C ATG P P ++W R NG  L+G+ H   SS       L L  ++  D G 
Sbjct: 342 LIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSG------LYLQNITQRDHGR 395

Query: 326 YICQAKNFLGASETVISLIVTEPPTST----------EH----------SGSPGALWART 365
           + C A N  G  +   ++IV  PP  T          EH          +  P  +W +T
Sbjct: 396 FTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKT 455

Query: 366 GG 367
           GG
Sbjct: 456 GG 457



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 24/72 (33%), Positives = 33/72 (45%), Gaps = 7/72 (9%)

Query: 275 CGATGVPGPEMSWRRANGR-PLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNF 333
           C A G P P + W +  G+ P+ G     V S GT    L +   +  D G Y CQA + 
Sbjct: 440 CEADGNPPPVIVWTKTGGQLPVEG--QHTVLSSGT----LRIDRAAQHDQGQYECQAVSS 493

Query: 334 LGASETVISLIV 345
           LG  +  + L V
Sbjct: 494 LGVKKVSVQLTV 505



 Score = 31.2 bits (69), Expect = 3.0
 Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 5/80 (6%)

Query: 267 LGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDY 326
           +G    + C A G P P ++W +  G  +  +    V  +GT    L +      D G Y
Sbjct: 524 VGKNINISCHAQGEPQPIITWNK-EGVQITESGKFHVDDEGT----LTIYDAGFPDQGRY 578

Query: 327 ICQAKNFLGASETVISLIVT 346
            C A+N  G + T + L VT
Sbjct: 579 ECVARNSFGLAVTNMFLTVT 598


>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
           sapiens]
          Length = 345

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 62/190 (32%), Positives = 86/190 (45%), Gaps = 19/190 (10%)

Query: 23  CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82
           CP +C C        S    V C+   +   P+ +PP T  L L+   I  +P  AFR +
Sbjct: 21  CPDKCYCQ-------SSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSV 73

Query: 83  GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142
             L  L L  N+LS L      GL+ L+ L L  N L +         P+LR LDL +N 
Sbjct: 74  PWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNN 133

Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNP 202
           +S +P       ENLT L +  NQL +L + L+ S   +            R+L L+DN 
Sbjct: 134 ISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSV------------RLLLLKDNL 181

Query: 203 WACDCRLYDL 212
           W C+C L  L
Sbjct: 182 WKCNCHLLGL 191


>gi|149773484 leucine rich repeat and fibronectin type III domain
           containing 1 [Homo sapiens]
          Length = 771

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 118/453 (26%), Positives = 161/453 (35%), Gaps = 94/453 (20%)

Query: 11  LALAWPPQARGF-CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRL--- 66
           L L W   +RG  CP +C C      + +   T++C    +   P +I      LRL   
Sbjct: 21  LLLLWAGASRGQPCPGRCICQ-----NVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDN 75

Query: 67  ---------------------ERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRG 105
                                 R  I +V   AF  L  L  L L  N L+E+    LRG
Sbjct: 76  FIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRG 135

Query: 106 LRRLRELRLPGNR-------------------------LAAFPWAALRDAPKLRLLDLQA 140
           L  LR L L  N+                         L A PW A+     L  L L  
Sbjct: 136 LGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDH 195

Query: 141 NRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQD 200
           N +  +       L  L  LD++SN+L +LP + +   +   TG  PP       +    
Sbjct: 196 NLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQ-GTGPKPP---TPLTVSFGG 251

Query: 201 NPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQL--ELRKCQGPELHP 258
           NP  C+C L         W   L   +    CA+P  L    F  +  E   C+ P L  
Sbjct: 252 NPLHCNCELL--------WLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCE-PPLIT 302

Query: 259 GVASIRSLL--GGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLP 316
             A  R+L+  G    LRC A G P P + W   +GR L  +    V  DGT    L + 
Sbjct: 303 RQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGT----LDVT 358

Query: 317 AVSHLDSGDYICQAKNFLGASETVISLIV----------TEPPTSTEHSGSPGALWARTG 366
             +  DSG + C A N  G +   + + V            PP  TE   S  A   R G
Sbjct: 359 ITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPG 418

Query: 367 GGGEAA--------AYNNKLVARHVPQIPKPAV 391
               AA          +N ++ R   Q P P +
Sbjct: 419 ANDSAAERRLVAAELTSNSVLIRWPAQRPVPGI 451


>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
           sapiens]
          Length = 593

 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 97/334 (29%), Positives = 132/334 (39%), Gaps = 67/334 (20%)

Query: 59  PDTSRLRLERTAIRRVPGEAFRPLGRLEQLWLP-YNALSELNALMLRGLRRLRELRLPGN 117
           P    LRL    I R+P  A R LG+L++L +  + +L  L+   L GL  L  L +   
Sbjct: 204 PALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLN-LSSLAITRC 262

Query: 118 RLAAFPWAALRDAPKLRLLDLQANRLSAVPAE---------------------AARFLEN 156
            L++ P+ AL     LR+LDL  N +SA+PA                      AA     
Sbjct: 263 NLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHG 322

Query: 157 LT---FLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLV 213
           LT    LD++ N L  L +    S   L T            L L  NP  CDCRL  L+
Sbjct: 323 LTAFHLLDVADNALQTLEETAFPSPDKLVT------------LRLSGNPLTCDCRLLWLL 370

Query: 214 HLLDGWAPNLAFIETELRCASPRSLAGVAFSQLELRKCQGPELHPGVASIRSLL------ 267
            L      +L F  +   CA P  + G +  +          L PG  + +  L      
Sbjct: 371 RL----RRHLDFGMSPPACAGPHHVQGKSLKEFS------DILPPGHFTCKPALIRKSGP 420

Query: 268 -------GGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSH 320
                  GG A+  C   G P P +SW R +G  L       V  DGT    L + +V  
Sbjct: 421 RWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLEDGT----LEIRSVQL 476

Query: 321 LDSGDYICQAKNFLG--ASETVISLIVTEPPTST 352
            D G Y+C   N  G  +  T + +I  EPP  T
Sbjct: 477 RDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGT 510



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 53/177 (29%), Positives = 76/177 (42%), Gaps = 9/177 (5%)

Query: 7   MLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRL 66
           +L+LL L  P  + G CP+ C C+       S+ + V+C    +   P  +P DT  L L
Sbjct: 17  LLFLLLL--PGGSGGSCPAVCDCT-------SQPQAVLCGHRQLEAVPGGLPLDTELLDL 67

Query: 67  ERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAA 126
               +  +       L  L++L L YN LS L      GL+ L  LRL GNRL       
Sbjct: 68  SGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGV 127

Query: 127 LRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLET 183
                 L LLDL+ N++      A   L +L  L++  N L+ +        A L T
Sbjct: 128 FSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLST 184


>gi|12007646 nyctalopin precursor [Homo sapiens]
          Length = 481

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 71/197 (36%), Positives = 93/197 (47%), Gaps = 22/197 (11%)

Query: 64  LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFP 123
           L L+   +R V   AF   G LE L L  N L+EL A   RGLRRLR L L GN L    
Sbjct: 211 LSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVA 270

Query: 124 WAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLET 183
            A   D  +L LL L  N ++ V   A + L  L  L L+ N+L       +++W   + 
Sbjct: 271 RAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRL------TVLAWVAFQP 324

Query: 184 GIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAF 243
           G F         L L  NPW CDCRL  L   ++G     +   T++ CASP S+AG+  
Sbjct: 325 GFF------LGRLFLFRNPWCCDCRLEWLRDWMEG-----SGRVTDVPCASPGSVAGLDL 373

Query: 244 SQLELRK-----CQGPE 255
           SQ+   +     C  PE
Sbjct: 374 SQVTFGRSSDGLCVDPE 390



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 59/170 (34%), Positives = 80/170 (47%), Gaps = 16/170 (9%)

Query: 23  CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82
           CP+ C+CS    G      +V C+   +   PA +P +   + L+R  +R +   AF  L
Sbjct: 31  CPAACACSTVERGC-----SVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTL 85

Query: 83  GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGN----RLAAFPWAALRDAPKLRLLDL 138
             L +L L +N LS +     +GL RL ELRL  N     L A  +AAL    +LR LDL
Sbjct: 86  PSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAAL---SRLRRLDL 142

Query: 139 QANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQEL----IVSWAHLETG 184
            A RL +VP      L  L  L    N   R+P  L     ++ AHLE G
Sbjct: 143 AACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERG 192


>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
           sapiens]
          Length = 370

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 66/218 (30%), Positives = 92/218 (42%), Gaps = 20/218 (9%)

Query: 23  CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82
           CP  C C        S++  V C+   +T  P  +P  T  L L    +  +P  AF  L
Sbjct: 39  CPFSCKCD-------SRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANL 91

Query: 83  GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142
             L++L L  N L  L   +   L  L EL+L  N +       LR +P LR LDL  N 
Sbjct: 92  SSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSING 151

Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNP 202
           L+ +P      L  L  L L SN+L  L +      A+L+            +L + DNP
Sbjct: 152 LAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQ------------LLQVGDNP 199

Query: 203 WACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG 240
           W CDC L +  H ++ W         +L C  P+ L G
Sbjct: 200 WECDCNLREFKHWME-WFSYRGGRLDQLACTLPKELRG 236


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 91/322 (28%), Positives = 125/322 (38%), Gaps = 34/322 (10%)

Query: 23  CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82
           CPS+C C            TV C    +   PA + P TS L L    IR +   AFR L
Sbjct: 36  CPSRCLCF---------RTTVRCMHLLLEAVPA-VAPQTSILDLRFNRIREIQPGAFRRL 85

Query: 83  GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142
             L  L L  N +  + +     L  L+ L L  N + +    A +    L  L L  N+
Sbjct: 86  RNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQ 145

Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNP 202
           +  +  ++ + L  L  L L +N++            HL  G F      +R L L  N 
Sbjct: 146 IETLDPDSFQHLPKLERLFLHNNRI-----------THLVPGTFNHLESMKR-LRLDSNT 193

Query: 203 WACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG--VAFSQLELRKCQGPEL--HP 258
             CDC +  L  LL  +A +    +    C  PR + G  VA    E   C+ P +   P
Sbjct: 194 LHCDCEILWLADLLKTYAES-GNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEP 252

Query: 259 GVASIRSLLGGTALLRCGATGVPGPEMSWRRANGR-PLNGTVHQEVSSDGTSWTLLGLPA 317
             A + S  G T    C A G P PE+ W R N    +       +  DGT    L +  
Sbjct: 253 QDADVTS--GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT----LMIQN 306

Query: 318 VSHLDSGDYICQAKNFLGASET 339
               D G Y C AKN  G  +T
Sbjct: 307 TQETDQGIYQCMAKNVAGEVKT 328



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 84/359 (23%), Positives = 136/359 (37%), Gaps = 57/359 (15%)

Query: 63  RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122
           +L L    I  +  ++F+ L +LE+L+L  N ++ L       L  ++ LRL  N L   
Sbjct: 138 QLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHC- 196

Query: 123 PWAALRDAPKLRLLDL------QANRLSAVPAEAARFLENLTFLDLSSNQL-------MR 169
                 D   L L DL        N  +A   E  R ++  +   ++  +L         
Sbjct: 197 ------DCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITS 250

Query: 170 LPQELIVSWAHLETGIFPPGHHPR-RVLGLQDN---PWACDCRLYDLVHLLDGWAPNLAF 225
            PQ+  V+  +          +P+  ++ L++N       D RL    +LLD     +  
Sbjct: 251 EPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRL----NLLDDGTLMIQN 306

Query: 226 I-ETE---LRCASPRSLAGVAFSQLELRKCQGPELHPGVASIRS---LLGGTALLRCGAT 278
             ET+    +C +      V   ++ LR    P     V   ++   L+G +  L C AT
Sbjct: 307 TQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSAT 366

Query: 279 GVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASE 338
           G P P +SW R +  PL       ++  G     L +  V   DSG+Y C A N + +  
Sbjct: 367 GHPPPRISWTRGDRTPLPVDPRVNITPSGG----LYIQNVVQGDSGEYACSATNNIDSVH 422

Query: 339 TVISLIVTEPPTST------------------EHSGSPGALWARTGGGGEAAAYNNKLV 379
               +IV   P  T                  E  G+P  + A T GG + +     LV
Sbjct: 423 ATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLV 481



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 40/161 (24%), Positives = 64/161 (39%), Gaps = 18/161 (11%)

Query: 268 GGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYI 327
           G T   +C A G P P ++W +  G  L+      V S GT    L +  V+  D G Y 
Sbjct: 447 GQTVDFQCEAKGNPPPVIAWTKG-GSQLSVDRRHLVLSSGT----LRISGVALHDQGQYE 501

Query: 328 CQAKNFLGASETVISLIVTEPPTSTEHSGSPGALWARTGGGGEAAAYNNKLVARHVPQIP 387
           CQA N +G S+ V++ +  +P  +   +  P       G   +    +           P
Sbjct: 502 CQAVNIIG-SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQ--------GEP 552

Query: 388 KPAVLATGPSVPSTKEELTLEHFQMDALGELSDGRAGPSEA 428
           +PA+      V  T+       F +   G L+    GP++A
Sbjct: 553 EPAITWNKDGVQVTES----GKFHISPEGFLTINDVGPADA 589



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 31/109 (28%), Positives = 50/109 (45%), Gaps = 11/109 (10%)

Query: 254 PELHPGVASIRS----LLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTS 309
           P + P  ASI S     +G    L C + G P P ++W + +G  +  +    +S +G  
Sbjct: 521 PRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNK-DGVQVTESGKFHISPEG-- 577

Query: 310 WTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSP 358
              L +  V   D+G Y C A+N +G++   + L V  P  S   +G P
Sbjct: 578 --FLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVS--RNGDP 622


>gi|55741571 leucine rich repeat and fibronectin type III domain
           containing 2 [Homo sapiens]
          Length = 789

 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 88/344 (25%), Positives = 126/344 (36%), Gaps = 51/344 (14%)

Query: 64  LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLR------------- 110
           L L R  I  +   +F  L  L  L L  N L  L    LRGL  L+             
Sbjct: 81  LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140

Query: 111 ------------ELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLT 158
                       +L L  N L   PW ++R    L  L L  N L  +       L+ L 
Sbjct: 141 DEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLA 200

Query: 159 FLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDG 218
            LDL+SN+L +LP + I + +        P   P        NP  C+C L         
Sbjct: 201 RLDLTSNRLQKLPPDPIFARSQASALTATP-FAPPLSFSFGGNPLHCNCELL-------- 251

Query: 219 WAPNLAFIETELRCASPRSLAGVAFSQLELRK--CQGPELHPGVASIRSLLGGTALLRCG 276
           W   L   +    C SP  L G  F  +   +  C+ P +      +  L G  A L+C 
Sbjct: 252 WLRRLERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCK 311

Query: 277 ATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGA 336
           A G P P + W   + R +  +    V  +GT    L +   +  DSG + C A N  G 
Sbjct: 312 AIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGT----LDIFITTSQDSGAFTCIAANAAGE 367

Query: 337 SETVISLIVTEPP---TSTEHSGSP--------GALWARTGGGG 369
           +  ++ + + + P    ST  +  P        G+     GGGG
Sbjct: 368 ATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGG 411


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 114/454 (25%), Positives = 158/454 (34%), Gaps = 128/454 (28%)

Query: 23  CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTA------------ 70
           CP  CSCS       ++A  V+C   D+   PASIP +T  L L+               
Sbjct: 57  CPVACSCS-------NQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHL 109

Query: 71  ------------------------------------IRRVPGEAFRPLGRLEQLWLPYNA 94
                                               +  VP +AF  L +L +LWL  N 
Sbjct: 110 RHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNP 169

Query: 95  -------------------LSELNALM----------------------------LRGLR 107
                              L EL  L                             L  L 
Sbjct: 170 IESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALV 229

Query: 108 RLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQL 167
           RL EL L GNRL      + +    LR L L   +++ +   A   L++L  L+LS N L
Sbjct: 230 RLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNL 289

Query: 168 MRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIE 227
           M LP +L           F P H   RV  L  NPW C+C +  L   L    P+     
Sbjct: 290 MSLPHDL-----------FTPLHRLERV-HLNHNPWHCNCDVLWLSWWLKETVPSNT--T 335

Query: 228 TELRCASPRSLAGVAFSQLELR--KCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEM 285
              RC +P  L G    +L+     C  P +      +    G  A L+C  TG     +
Sbjct: 336 CCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKC-RTGTSMTSV 394

Query: 286 SWRRANGRPL-NGTVHQEVS--SDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVIS 342
           +W   NG  + +G+    +S   DGT    L    V+  D+G Y C   N  G +    +
Sbjct: 395 NWLTPNGTLMTHGSYRVRISVLHDGT----LNFTNVTVQDTGQYTCMVTNSAGNTTASAT 450

Query: 343 LIVTE-PPTSTEHSGSPGALWARTGG-GGEAAAY 374
           L V+   P +   +GS G     +GG GG +  Y
Sbjct: 451 LNVSAVDPVAAGGTGSGGGGPGGSGGVGGGSGGY 484


>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 63/190 (33%), Positives = 82/190 (43%), Gaps = 16/190 (8%)

Query: 64  LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFP 123
           L L+R  ++ +    FR L  L+ L+L  NAL  L     R L  L  L L GNR+++ P
Sbjct: 135 LHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVP 194

Query: 124 WAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLET 183
             A R    L  L L  NR++ V   A R L  L  L L +N L  LP E +     L+ 
Sbjct: 195 ERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQ- 253

Query: 184 GIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAF 243
                       L L DNPW CDCR       L  W        +E+ C+ P+ LAG   
Sbjct: 254 -----------YLRLNDNPWVCDCR----ARPLWAWLQKFRGSSSEVPCSLPQRLAGRDL 298

Query: 244 SQLELRKCQG 253
            +L     QG
Sbjct: 299 KRLAANDLQG 308



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 37/106 (34%), Positives = 44/106 (41%), Gaps = 6/106 (5%)

Query: 63  RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122
           RL L +  +  V   AFR LGRL  L+L  N LS L    L  LR L+ LRL  N     
Sbjct: 206 RLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN----- 260

Query: 123 PWAA-LRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQL 167
           PW    R  P    L       S VP    + L       L++N L
Sbjct: 261 PWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDL 306



 Score = 33.1 bits (74), Expect = 0.78
 Identities = 20/45 (44%), Positives = 23/45 (51%)

Query: 138 LQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLE 182
           L  NR+S VPA + R   NLT L L SN L R+        A LE
Sbjct: 64  LHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLE 108


>gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]
          Length = 347

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 60/177 (33%), Positives = 78/177 (44%), Gaps = 8/177 (4%)

Query: 64  LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFP 123
           L L    +R++P         L  L L  N L  L   +LRG  +L  L L GN+L    
Sbjct: 169 LDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLG 228

Query: 124 WAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLET 183
              L   P LR L L  N+L+ V A A + L  L  LDLS+N L  +P+ L   WA L  
Sbjct: 229 KDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGL---WASLG- 284

Query: 184 GIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG 240
               P    R    +  NPW CD  L DL   L      + F + + RCA P ++ G
Sbjct: 285 ---QPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKM-FSQNDTRCAGPEAVKG 337



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 52/177 (29%), Positives = 78/177 (44%), Gaps = 10/177 (5%)

Query: 7   MLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRL 66
           +L L A AW     G   S   C +     GS   ++ C  P     P  +P DT  L +
Sbjct: 26  LLLLAASAW-----GVTLSPKDCQVFRSDHGS---SISCQPPAEI--PGYLPADTVHLAV 75

Query: 67  ERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAA 126
           E   +  +P    +   +L++L L  N L  L+   LR + +LR L L  N L   P   
Sbjct: 76  EFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGL 135

Query: 127 LRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLET 183
            + +  L  L L+ N+L  +       L+ L  LDLS N+L +LP  L+ ++  L T
Sbjct: 136 FQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRT 192


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 64/192 (33%), Positives = 78/192 (40%), Gaps = 23/192 (11%)

Query: 56  SIPPDTSR-------LRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRR 108
           S+ PDT +       L L R  +  +PG  FR L  L+ L+L  N+L  L   +   L  
Sbjct: 121 SLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180

Query: 109 LRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLM 168
           L  L L GNRL        R    L  L L  NRL  V   A R L  LT L L +N L 
Sbjct: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLA 240

Query: 169 RLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIET 228
            LP E +     LE             L L  NPWACDCR       L  W        +
Sbjct: 241 SLPGEALADLPSLE------------FLRLNANPWACDCR----ARPLWAWFQRARVSSS 284

Query: 229 ELRCASPRSLAG 240
           ++ CA+P    G
Sbjct: 285 DVTCATPPERQG 296



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 59/176 (33%), Positives = 80/176 (45%), Gaps = 13/176 (7%)

Query: 7   MLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRL 66
           +L LLAL   P A   CP  C+C        S   TV C   + +  P S+PP T RL L
Sbjct: 18  LLMLLAL---PLAAPSCPMLCTCY-------SSPPTVSCQANNFSSVPLSLPPSTQRLFL 67

Query: 67  ERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNR-LAAFPWA 125
           +   IR +    F     L  LWL  N LS +     R L+ L EL L  NR L +    
Sbjct: 68  QNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPD 125

Query: 126 ALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHL 181
             +   +L+ L L   +LS++P    R L +L +L L  N L+ L  +L    A+L
Sbjct: 126 TFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANL 181


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 86/316 (27%), Positives = 134/316 (42%), Gaps = 33/316 (10%)

Query: 46  NDPDMTLPPASIPPDTSRLRLERTAIRR---VPGEAFRPLGRLEQLWLPYNALSELNALM 102
           N+P  ++P  +     S  RL+   ++R   +   AF  L  L  L L    L E+  L 
Sbjct: 157 NNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLT 216

Query: 103 LRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDL 162
              L +L EL L GN L+A    + +    L+ L +  +++  +   A   L++L  ++L
Sbjct: 217 --PLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINL 274

Query: 163 SSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPN 222
           + N L  LP +L           F P HH  R+  L  NPW C+C +      L  W  +
Sbjct: 275 AHNNLTLLPHDL-----------FTPLHHLERI-HLHHNPWNCNCDIL----WLSWWIKD 318

Query: 223 LAFIETE--LRCASPRSLAGVAFSQLELR--KCQGPELHPGVASIRSLLGGTALLRCGAT 278
           +A   T    RC +P +L G    +L+     C  P +    A +    G  A L+C A+
Sbjct: 319 MAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRAS 378

Query: 279 GVPGPEMSWRRANGRPLNGTVHQ---EVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLG 335
                 +SW   NG  +    ++    V SDGT    L    V+  D+G Y C   N +G
Sbjct: 379 -TSLTSVSWITPNGTVMTHGAYKVRIAVLSDGT----LNFTNVTVQDTGMYTCMVSNSVG 433

Query: 336 ASETVISLIVTEPPTS 351
            +    +L VT   T+
Sbjct: 434 NTTASATLNVTAATTT 449


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 56/148 (37%), Positives = 67/148 (45%), Gaps = 7/148 (4%)

Query: 23  CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPL 82
           CP  C C         ++R   C    +   P   P DT  L L R     VP  AF  L
Sbjct: 396 CPRACVCV-------PESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGL 448

Query: 83  GRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANR 142
           G L  L L +  ++EL A  L GL RL  L L  N+LA    AAL  AP+L  L L+ NR
Sbjct: 449 GHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNR 508

Query: 143 LSAVPAEAARFLENLTFLDLSSNQLMRL 170
              VP  A R L +L  L L  N + RL
Sbjct: 509 FLQVPGAALRALPSLFSLHLQDNAVDRL 536



 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 57/170 (33%), Positives = 78/170 (45%), Gaps = 8/170 (4%)

Query: 3   VALGMLWLLALAWPPQARGF-CPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDT 61
           + L +L LL LA   QA    CP  C C      D S+ R V C   ++T  P +IP  T
Sbjct: 12  LVLPLLVLLLLAPARQAAAQRCPQACIC------DNSR-RHVACRYQNLTEVPDAIPELT 64

Query: 62  SRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAA 121
            RL L+   ++ +P  AF+ +  L  L L +  +  +     RGL RL  L L  N L  
Sbjct: 65  QRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRE 124

Query: 122 FPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLP 171
            P  AL     LR L+L+ N L  +       L  L  L+L+ N L+ LP
Sbjct: 125 LPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLP 174



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 68/218 (31%), Positives = 89/218 (40%), Gaps = 39/218 (17%)

Query: 63  RLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAF 122
           RL LE  A+  +    F  LG L  L L +NAL  L A+  +GL R+R LRL  N L+  
Sbjct: 138 RLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVL 197

Query: 123 PWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQL--------MRLP--Q 172
              AL   P LR L L  N L A+P         L  L+L  N L        + LP  +
Sbjct: 198 APEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLR 257

Query: 173 ELIV-----------SWAHL-----------ETGIFPP--GHHPRRVLGLQDNPWACDCR 208
           EL++           ++AH            +    PP  G    R L LQ NP  C C+
Sbjct: 258 ELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCGCQ 317

Query: 209 LYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQL 246
              L+  L       A + ++  C  PR L G A   L
Sbjct: 318 ARPLLEWL-----ARARVRSDGACQGPRRLRGEALDAL 350



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 68/218 (31%), Positives = 85/218 (38%), Gaps = 41/218 (18%)

Query: 59  PDTSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNR 118
           P    L LER    +VPG A R L  L  L L  NA+  L    L   R LR + L GNR
Sbjct: 497 PRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNR 556

Query: 119 LAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLP------- 171
           +      AL  A +L  L L  N+L  VP  A   L  L  L LS N L  L        
Sbjct: 557 ITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPV 616

Query: 172 ----QELIVSWAHLE-------TGIFP------------------PGHHPRRVLGLQDNP 202
               Q L ++ + LE       +G+ P                  P      ++ L  NP
Sbjct: 617 GRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNP 676

Query: 203 WACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG 240
           + CDC+L  L   L G   NL    T   CA+P +  G
Sbjct: 677 FHCDCQLLPLHRWLTGL--NLRVGAT---CATPPNARG 709



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 27/66 (40%), Positives = 34/66 (51%)

Query: 110 RELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMR 169
           + L L GN L   P AA +  P L  LDL+   +  V   A R L  L  L+L+SN L  
Sbjct: 65  QRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRE 124

Query: 170 LPQELI 175
           LPQE +
Sbjct: 125 LPQEAL 130


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,151,688
Number of Sequences: 37866
Number of extensions: 1253738
Number of successful extensions: 6690
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 254
Number of HSP's successfully gapped in prelim test: 256
Number of HSP's that attempted gapping in prelim test: 3728
Number of HSP's gapped (non-prelim): 2118
length of query: 623
length of database: 18,247,518
effective HSP length: 108
effective length of query: 515
effective length of database: 14,157,990
effective search space: 7291364850
effective search space used: 7291364850
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.