Search of human proteins with 14149627

Search of human proteins with 14149627

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
         (952 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]           1982   0.0  
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]   1105   0.0  
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]   1097   0.0  
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]            809   0.0  
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]                  383   e-106
gi|22550104 ubiquitin specific protease 32 [Homo sapiens]             289   8e-78
gi|109638751 ubiquitin specific protease 6 [Homo sapiens]             266   9e-71
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]            196   9e-50
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]            196   9e-50
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]            196   9e-50
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]   166   1e-40
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi...   166   1e-40
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]           161   2e-39
gi|148612811 ubiquitin specific protease 43 [Homo sapiens]            159   9e-39
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]                  141   3e-33
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]             128   3e-29
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]             128   3e-29
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]   110   6e-24
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]   110   6e-24
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]   110   6e-24
gi|41152235 ubiquitin specific protease 51 [Homo sapiens]             104   3e-22
gi|183396780 ubiquitin specific protease 20 [Homo sapiens]            104   4e-22
gi|183397136 ubiquitin specific protease 20 [Homo sapiens]            104   4e-22
gi|183397134 ubiquitin specific protease 20 [Homo sapiens]            104   4e-22
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]                103   1e-21
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]        102   1e-21
gi|45267835 ubiquitin specific protease 50 [Homo sapiens]             101   3e-21
gi|239751420 PREDICTED: similar to hCG2039376 [Homo sapiens]           99   2e-20
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]    96   2e-19
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]     96   2e-19

>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
          Length = 952

 Score = 1982 bits (5136), Expect = 0.0
 Identities = 952/952 (100%), Positives = 952/952 (100%)

Query: 1   MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNV 60
           MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNV
Sbjct: 1   MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNV 60

Query: 61  YPGPIDNSGLLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWYTLMEGQEPIARKVVEQ 120
           YPGPIDNSGLLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWYTLMEGQEPIARKVVEQ
Sbjct: 61  YPGPIDNSGLLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWYTLMEGQEPIARKVVEQ 120

Query: 121 GMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLW 180
           GMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLW
Sbjct: 121 GMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLW 180

Query: 181 NKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPNVKNSNYCLPSYT 240
           NKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPNVKNSNYCLPSYT
Sbjct: 181 NKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPNVKNSNYCLPSYT 240

Query: 241 AYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFD 300
           AYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFD
Sbjct: 241 AYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFD 300

Query: 301 NPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLL 360
           NPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLL
Sbjct: 301 NPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLL 360

Query: 361 DGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCP 420
           DGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCP
Sbjct: 361 DGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCP 420

Query: 421 ECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTAL 480
           ECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTAL
Sbjct: 421 ECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTAL 480

Query: 481 SALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVIIPV 540
           SALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVIIPV
Sbjct: 481 SALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVIIPV 540

Query: 541 CLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMCRYVKISTETEETEG 600
           CLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMCRYVKISTETEETEG
Sbjct: 541 CLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMCRYVKISTETEETEG 600

Query: 601 SLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGGDND 660
           SLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGGDND
Sbjct: 601 SLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGGDND 660

Query: 661 SENGLCTEDTCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFL 720
           SENGLCTEDTCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFL
Sbjct: 661 SENGLCTEDTCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFL 720

Query: 721 ALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYC 780
           ALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYC
Sbjct: 721 ALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYC 780

Query: 781 PNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLINPN 840
           PNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLINPN
Sbjct: 781 PNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLINPN 840

Query: 841 AGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLF 900
           AGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLF
Sbjct: 841 AGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLF 900

Query: 901 YQRQDTFSGTGFFPLDRETKGASAATGIPLESDEDSNDNDNDIENENCMHTN 952
           YQRQDTFSGTGFFPLDRETKGASAATGIPLESDEDSNDNDNDIENENCMHTN
Sbjct: 901 YQRQDTFSGTGFFPLDRETKGASAATGIPLESDEDSNDNDNDIENENCMHTN 952


>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
          Length = 916

 Score = 1105 bits (2857), Expect = 0.0
 Identities = 553/912 (60%), Positives = 680/912 (74%), Gaps = 42/912 (4%)

Query: 1   MAEGGAA----DLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMG 56
           MAEGG      D +TQ+S++  L++T+L++G  WYL+DSRWFKQWKKYVGFDSWD Y +G
Sbjct: 1   MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG 60

Query: 57  DQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWYTLMEGQEPIARK 116
           + N++PGPIDNSGL  D ++Q+LKEHLIDELDY+L+PTE WNKL++WY  +EGQ+PI RK
Sbjct: 61  EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK 120

Query: 117 VVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKE 176
           VVE G+FVKHCKVEVYL ELKLCEN +  NV++  FSKADTI TIEKE+RK+F+IP E+E
Sbjct: 121 VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE 180

Query: 177 TRLWNKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPNVKNSNYCL 236
           TRLWNKYMSNT+E L+K D+T+QDAGLYQGQVLVIE +NEDGTWPR     N    +   
Sbjct: 181 TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSNGSGFS--- 237

Query: 237 PSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEE 296
                  +Y+  EP  ++ QPGLCGL NLGNTCFMNSA+QCLSNT PLT+YFL D+Y+ E
Sbjct: 238 ------ASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAE 291

Query: 297 LNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELL 356
           +N DNPLGM+GEIA++YAELIKQMWSG+ ++V PR FKTQVGRFAPQFSGYQQQD QELL
Sbjct: 292 INRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELL 351

Query: 357 AFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKST 416
           AFLLDGLHEDLNR++KKPY++LKDA+GRPD VVA+EAWENH  RNDS+IVD FHGLFKST
Sbjct: 352 AFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKST 411

Query: 417 LVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDL 476
           LVCPECAK+SVTFDPFCYLTLPLP+KK+R +EV+LV  DP  +P QY+V VP +G + DL
Sbjct: 412 LVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDL 471

Query: 477 CTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHV 536
           C ALS LSGI A+ M+V D+YNHRFH+IF MDE L+ IM RDDI+V+E+     + +E V
Sbjct: 472 CEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECV 531

Query: 537 IIPVCLREKFRHSSYTHHTGSSLFGQPFLMAVPRNN-TEDKLYNLLLLRMCRYVKISTET 595
            +PV  RE+    S T  + S+L+GQP L++VP++  T + LY  +  R+ RYVK     
Sbjct: 532 TLPVYFRERKSRPSST-SSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPD 590

Query: 596 EETEGSLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSV 655
           E     L            P   +   +  E E +E  +   + +E  SE E S  ED  
Sbjct: 591 EFGSSPLE-----------PGACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGS-GEDEP 638

Query: 656 GGDNDSENGLCTEDTCKGQLTGHKKRLFTFQF-NNLGNTDINYIKDDTRHIRFDDRQLRL 714
           G D        T+   KGQ     KRLFTF   N+ G  DIN        +  D + L+L
Sbjct: 639 GNDPSE----TTQKKIKGQPC--PKRLFTFSLVNSYGTADIN-------SLAADGKLLKL 685

Query: 715 DERSFLALDWDPDLKKRYFDENAAEDFEKHES-VEYKPPKKPFVKLKDCIELFTTKEKLG 773
           + RS LA+DWD + ++ Y+DE  +E +EKH S ++ +  KK  V L+DCIELFTT E LG
Sbjct: 686 NSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLG 745

Query: 774 AEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMS 833
             DPWYCPNCK+HQQATKK DLWSLP +LVVHLKRFSY+RY RDKLDT+V+FPI  L+MS
Sbjct: 746 EHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMS 805

Query: 834 EFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVS 893
           EF+ N +A P  Y+LIAVSNHYG MG GHYTA+AKNK +GKWYYFDDS+VS ASEDQIV+
Sbjct: 806 EFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVT 865

Query: 894 KAAYVLFYQRQD 905
           KAAYVLFYQR+D
Sbjct: 866 KAAYVLFYQRRD 877


>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
          Length = 963

 Score = 1097 bits (2836), Expect = 0.0
 Identities = 559/950 (58%), Positives = 686/950 (72%), Gaps = 71/950 (7%)

Query: 1   MAEGGAA----DLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMG 56
           MAEGG      D +TQ+S++  L++T+L++G  WYL+DSRWFKQWKKYVGFDSWD Y +G
Sbjct: 1   MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG 60

Query: 57  DQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWYTLMEGQEPIARK 116
           + N++PGPIDNSGL  D ++Q+LKEHLIDELDY+L+PTE WNKL++WY  +EGQ+PI RK
Sbjct: 61  EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK 120

Query: 117 VVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKE 176
           VVE G+FVKHCKVEVYL ELKLCEN +  NV++  FSKADTI TIEKE+RK+F+IP E+E
Sbjct: 121 VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE 180

Query: 177 TRLWNKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPR---------GPS-- 225
           TRLWNKYMSNT+E L+K D+T+QDAGLYQGQVLVIE +NEDGTWPR          PS  
Sbjct: 181 TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRN 240

Query: 226 ---TPNVKNSNYCLPSYTAYKN------------------------YDYSEPGRNNEQPG 258
              +P    S Y   S +   N                        Y+  EP  ++ QPG
Sbjct: 241 FTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPG 300

Query: 259 LCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIK 318
           LCGL NLGNTCFMNSA+QCLSNT PLT+YFL D+Y+ E+N DNPLGM+GEIA++YAELIK
Sbjct: 301 LCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIK 360

Query: 319 QMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQL 378
           QMWSG+ ++V PR FKTQVGRFAPQFSGYQQQD QELLAFLLDGLHEDLNR++KKPY++L
Sbjct: 361 QMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL 420

Query: 379 KDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLP 438
           KDA+GRPD VVA+EAWENH  RNDS+IVD FHGLFKSTLVCPECAK+SVTFDPFCYLTLP
Sbjct: 421 KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLP 480

Query: 439 LPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYN 498
           LP+KK+R +EV+LV  DP  +P QY+V VP +G + DLC ALS LSGI A+ M+V D+YN
Sbjct: 481 LPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN 540

Query: 499 HRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVIIPVCLREKFRHSSYTHHTGSS 558
           HRFH+IF MDE L+ IM RDDI+V+E+     + +E V +PV  RE+    S T  + S+
Sbjct: 541 HRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSST-SSASA 599

Query: 559 LFGQPFLMAVPRNN-TEDKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPNG 617
           L+GQP L++VP++  T + LY  +  R+ RYVK     E     L            P  
Sbjct: 600 LYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLE-----------PGA 648

Query: 618 IHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGGDNDSENGLCTEDTCKGQLTG 677
            +   +  E E +E  +   + +E  SE E S  ED  G D        T+   KGQ   
Sbjct: 649 CNGSRNSCEGEDEEEMEHQEEGKEQLSETEGS-GEDEPGNDPSE----TTQKKIKGQPC- 702

Query: 678 HKKRLFTFQF-NNLGNTDINYIKDDTRHIRFDDRQLRLDERSFLALDWDPDLKKRYFDEN 736
             KRLFTF   N+ G  DIN        +  D + L+L+ RS LA+DWD + ++ Y+DE 
Sbjct: 703 -PKRLFTFSLVNSYGTADIN-------SLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQ 754

Query: 737 AAEDFEKHES-VEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDL 795
            +E +EKH S ++ +  KK  V L+DCIELFTT E LG  DPWYCPNCK+HQQATKK DL
Sbjct: 755 ESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDL 814

Query: 796 WSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHY 855
           WSLP +LVVHLKRFSY+RY RDKLDT+V+FPI  L+MSEF+ N +A P  Y+LIAVSNHY
Sbjct: 815 WSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHY 874

Query: 856 GGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQD 905
           G MG GHYTA+AKNK +GKWYYFDDS+VS ASEDQIV+KAAYVLFYQR+D
Sbjct: 875 GAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRD 924


>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
          Length = 963

 Score =  809 bits (2089), Expect = 0.0
 Identities = 425/902 (47%), Positives = 577/902 (63%), Gaps = 86/902 (9%)

Query: 24  LRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQN--VYPGPIDNSGLLKDGDAQSLKE 81
           LR G++W+LV+  W+KQW+ YV        Q GDQ+   +PG I+N+ L +D     LKE
Sbjct: 96  LRAGESWFLVEKHWYKQWEAYV--------QGGDQDSSTFPGCINNATLFQDEINWRLKE 147

Query: 82  HLIDELDYILLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCEN 141
            L++  DY+LLP   W+ LVSWY L  GQ PI RKV+E     K   VEVY  EL L  +
Sbjct: 148 GLVEGEDYVLLPAAAWHYLVSWYGLEHGQPPIERKVIELPNIQK---VEVYPVELLLVRH 204

Query: 142 GNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLWNKYMSNTFEPLNKPDSTIQDA 201
            ++    T +FS  D+I  + +  R+ F +  +++TRLW K    + + L     T+ DA
Sbjct: 205 NDLGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDA 264

Query: 202 GLYQGQVLVIEQKNEDGTWPRGPSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCG 261
            L  GQ++++E + +DGTWP      +V N+N       + ++ D+        QPG+CG
Sbjct: 265 ALETGQLIIMETRKKDGTWPSAQL--HVMNNNM------SEEDEDFKG------QPGICG 310

Query: 262 LSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMW 321
           L+NLGNTCFMNSA+QCLSN P LTEYFLN+ Y EELNF NPLGM+GEIA++YA+L+KQ W
Sbjct: 311 LTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAW 370

Query: 322 SGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDA 381
           SG    + P  FK +VG FA QF GYQQ D QELL+FLLDGLHEDLNR++KK Y++L DA
Sbjct: 371 SGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDA 430

Query: 382 DGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPM 441
            GRPD+ VA+EAW+NH +RNDS+IVD FHGLFKSTLVCP+C  +SVTFDPFCYL++PLP+
Sbjct: 431 AGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPI 490

Query: 442 KKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRF 501
             +R LEV+ + MDP  KP Q+++VVPK G I DLC ALS  +GI  ++M+V D+++HRF
Sbjct: 491 SHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPERMMVADVFSHRF 550

Query: 502 HRIFAMDENLSSIMERDDIYVFEIN--INRTEDT-EHVIIPVCLREKFRHSSYTH-HTGS 557
           ++++ ++E LSSI++RDDI+V+E++  I   E + E +++PV LRE+     Y + + G 
Sbjct: 551 YKLYQLEEPLSSILDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRERTPARDYNNSYYGL 610

Query: 558 SLFGQPFLMAVPRNN-TEDKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPN 616
            LFG P L++VPR+  T + LYN+L+ R+ RYV      +E +G                
Sbjct: 611 MLFGHPLLVSVPRDRFTWEGLYNVLMYRLSRYVTKPNSDDEDDG---------------- 654

Query: 617 GIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGGDNDSENGLCTE-----DTC 671
                        DE +D+     ++P  +      D         +G+        D C
Sbjct: 655 -------------DEKEDDEEDKDDVPGPSTGGSLRDPEPEQAGPSSGVTNRCPFLLDNC 701

Query: 672 KGQL----TGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFLALDWDPD 727
            G         +K+LFT Q  N   T       +  H            + ++A+DW+P+
Sbjct: 702 LGTSQWPPRRRRKQLFTLQTVNSNGTSDRTTSPEEVH-----------AQPYIAIDWEPE 750

Query: 728 LKKRYFDENAAEDFEKHESVEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQ 787
           +KKRY+DE  AE + KH+ V Y   K P V+L++CIELFTT E L  E+PWYCP+CK+HQ
Sbjct: 751 MKKRYYDEVEAEGYVKHDCVGYVMKKAP-VRLQECIELFTTVETLEKENPWYCPSCKQHQ 809

Query: 788 QATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLINP----NAGP 843
            ATKKLDLW LP +L++HLKRFSY+++ R+KLDTLV+FPI DLD SEF+I P    N   
Sbjct: 810 LATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVIQPQNESNPEL 869

Query: 844 CRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQR 903
            +Y+LIAVSNHYGGM  GHYT FA NKD G+W+YFDD+SVS  +E+QI SKAAYVLFYQR
Sbjct: 870 YKYDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQR 929

Query: 904 QD 905
           QD
Sbjct: 930 QD 931


>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
          Length = 1318

 Score =  383 bits (984), Expect = e-106
 Identities = 250/739 (33%), Positives = 372/739 (50%), Gaps = 105/739 (14%)

Query: 257  PGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAEL 316
            PG  GL NLGNTCFMNS IQ LSNT  L ++F +  ++ E+N++NPLG  G +A  +A L
Sbjct: 494  PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVL 553

Query: 317  IKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYI 376
            ++ +W G      P   K  V   A QF+GY Q D QE +AFLLDGLHEDLNRI+ KPY 
Sbjct: 554  LRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYT 613

Query: 377  QLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLT 436
            +  D+DGRPD+VVAEEAW+ H  RNDS IVD+F G +KS LVCP CAK+S+TFDPF YL 
Sbjct: 614  ETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLP 673

Query: 437  LPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNIL-DLCTALSALSGIPADKMIVTD 495
            +PLP +K++ L V+    +P +KP+++ V V K  +   ++  +LS    +  + + + +
Sbjct: 674  VPLP-QKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAE 732

Query: 496  IYNHRFHRIF----AMD-----------ENLSSIMERDDIYVFEIN-------------- 526
            +  +RFHR+F    ++D           E LSS + ++ + V E+               
Sbjct: 733  VIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCA 792

Query: 527  -INRTEDTEHVIIPVCLR--------EKFRHSSYTHHTG---SSLFGQPFLMAVPRNNTE 574
               R + +E   +  C R        +  + + +  H G       G PFL++VP +   
Sbjct: 793  ACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLT 852

Query: 575  DKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDD 634
                  LL    RY     +     G +       +    P G     S   +E  + + 
Sbjct: 853  YARLAQLLEGYARYSVSVFQPPFQPGRMA------LESQSP-GCTTLLSTGSLEAGDSER 905

Query: 635  ESSQDQELPSENENSQSEDSVG--------GDNDSENGLCTEDTCKGQL----------- 675
            +  Q  EL      ++ +  +         G   S +G+ +E    G +           
Sbjct: 906  DPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERV 965

Query: 676  -----------------TGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERS 718
                               H  + F ++ ++         K DT         L L +  
Sbjct: 966  SRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDT--------PLELGDDC 1017

Query: 719  FLALDWDPDLKKRYFDENAAEDFEKHESVEY--KPPKKPFVKLKDCIELFTTKEKLGAED 776
             LAL W  + + + F   A+++ E  E      +  +     L  C+ LFT  E L  E+
Sbjct: 1018 SLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEE 1077

Query: 777  PWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYM-RDKLDTLVDFPINDLDMSEF 835
             WYCP CK+H++A+K+L LW LP VL+V LKRFS+  ++ RDK++ LV+FP+ +LD+S+F
Sbjct: 1078 AWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKF 1137

Query: 836  LINPNAGPC-RYNLIAVSNHYGGMGGGHYTAFAK-------NKDDGKWYYFDDSSVSTAS 887
             I         Y+L AV NHYGGM GGHYTA A+        + D  W  FDDS+V+T  
Sbjct: 1138 CIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVD 1197

Query: 888  EDQIVSKAAYVLFYQRQDT 906
            E Q+V++ AYVLFY+R+++
Sbjct: 1198 ESQVVTRYAYVLFYRRRNS 1216


>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
          Length = 1604

 Score =  289 bits (740), Expect = 8e-78
 Identities = 174/484 (35%), Positives = 264/484 (54%), Gaps = 38/484 (7%)

Query: 64  PIDNSGLLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWYTL-MEGQEPIARK----VV 118
           P+  + L  +G        LI   DY ++P   W  L  WY   +    P+ +     + 
Sbjct: 534 PVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLALPRPVIKNSKTDIP 593

Query: 119 EQGMFVKHCKVEVYLTELKLCENG---NMNNV------------VTRRFSKADTIDTIEK 163
           E  +F ++          +  ++    NM NV             T  FS+  TI  I +
Sbjct: 594 ELELFPRYLLFLRQQPATRTQQSNIWVNMGNVPSPNAPLKRVLAYTGCFSRMQTIKEIHE 653

Query: 164 EIRKIFSIPDEKETRLWNKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRG 223
            + +   I +E + RLW     N    L+  D  ++   +   Q LVIE +N+D +WP  
Sbjct: 654 YLSQRLRIKEE-DMRLWLYNSENYLTLLDDEDHKLEYLKIQDEQHLVIEVRNKDMSWPEE 712

Query: 224 PSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPP 283
            S   + NS+         K   +  P     + G  GLSNLGNTCFMNS+IQC+SNT P
Sbjct: 713 MSF--IANSS---------KIDRHKVP----TEKGATGLSNLGNTCFMNSSIQCVSNTQP 757

Query: 284 LTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQ 343
           LT+YF++ ++  ELN  NP+GM+G +AK Y +L++++WSG    V P   +  + ++AP+
Sbjct: 758 LTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPR 817

Query: 344 FSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDS 403
           F+G+QQQD QELLAFLLDGLHEDLNR+ +KPY++LKD+DGRPD  VA EAW+NHL+RN S
Sbjct: 818 FNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRS 877

Query: 404 IIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQY 463
           I+VD+FHG  +S + C  C  ISV FDPF +L+LPLPM     LE+ ++++D  T P++Y
Sbjct: 878 IVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLDG-TTPVRY 936

Query: 464 KVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVF 523
            + +        L   LS L G+ ++++++ +++     + F  D     +     +  F
Sbjct: 937 GLRLNMDEKYTGLKKQLSDLCGLNSEQILLAEVHGSNI-KNFPQDNQKVRLSVSGFLCAF 995

Query: 524 EINI 527
           EI +
Sbjct: 996 EIPV 999



 Score =  101 bits (251), Expect = 4e-21
 Identities = 49/131 (37%), Positives = 75/131 (57%), Gaps = 3/131 (2%)

Query: 718  SFLALDWDPDLKKRYFDENAAEDFEKHESVEY--KPPKKPFVKLKDCIELFTTKEKLGAE 775
            +++A+DWDP      +  +     ++HESVE   +   +P + L  C+  FT++E+LG  
Sbjct: 1193 AYIAVDWDPTALHLRYQTSQERVVDEHESVEQSRRAQAEP-INLDSCLRAFTSEEELGEN 1251

Query: 776  DPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEF 835
            + +YC  CK H  ATKKLDLW LPP+L++HLKRF +      K   +V FP    D S F
Sbjct: 1252 EMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAF 1311

Query: 836  LINPNAGPCRY 846
            L+  +   C++
Sbjct: 1312 LVPRDPALCQH 1322



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 35/92 (38%), Positives = 53/92 (57%), Gaps = 5/92 (5%)

Query: 846  YNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQD 905
            YNL A+S H G +GGGHY  +AKN  + KWY ++DSS      D+I + +AY+LFY++Q 
Sbjct: 1510 YNLYAISCHSGILGGGHYVTYAKN-PNCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQ- 1567

Query: 906  TFSGTGFFPLDRETKGASAATGIPLESDEDSN 937
               G  +     +T G   A    ++ D +S+
Sbjct: 1568 ---GIDYAQFLPKTDGKKMADTSSMDEDFESD 1596



 Score = 38.5 bits (88), Expect = 0.030
 Identities = 18/64 (28%), Positives = 30/64 (46%), Gaps = 6/64 (9%)

Query: 24  LRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHL 83
           L+ G  W+++  +W++QWK+YV      KY      + P  + N G    G A    E +
Sbjct: 390 LQAGHNWFIISMQWWQQWKEYV------KYDANPVVIEPSSVLNGGKYSFGTAAHPMEQV 443

Query: 84  IDEL 87
            D +
Sbjct: 444 EDRI 447


>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
          Length = 1406

 Score =  266 bits (679), Expect = 9e-71
 Identities = 138/323 (42%), Positives = 204/323 (63%), Gaps = 7/323 (2%)

Query: 208 VLVIEQKNEDGTWPRGPSTPNVKNSNYCLP---SYTAYKNYDYSEPGRNNEQPGLCGLSN 264
           V  I Q+++  T  +      V N +   P   S+TA  N    +  +   + G  GLSN
Sbjct: 479 VRAISQEDQLATCWQAEHCGEVHNKDMSWPEEMSFTA--NSSKIDRQKVPTEKGATGLSN 536

Query: 265 LGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGK 324
           LGNTCFMNS+IQC+SNT PLT+YF++ ++  ELN  NP+GM+G +AK Y +L++++WSG 
Sbjct: 537 LGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGT 596

Query: 325 FSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGR 384
              V P   +  + ++AP+F G+QQQD QELLAFLLDGLHEDLNR+ +KPY++LKD+DGR
Sbjct: 597 QKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGR 656

Query: 385 PDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKE 444
           PD  VA EAW+NHL+RN SIIVD+FHG  +S + C  C  ISV FDPF +L+LPLPM   
Sbjct: 657 PDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSY 716

Query: 445 RTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRI 504
             LE+ ++++D  T P++Y + +        L   L  L G+ ++++++ ++++    + 
Sbjct: 717 MDLEITVIKLDG-TTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEVHDSNI-KN 774

Query: 505 FAMDENLSSIMERDDIYVFEINI 527
           F  D     +     +  FEI +
Sbjct: 775 FPQDNQKVQLSVSGFLCAFEIPV 797



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 48/131 (36%), Positives = 72/131 (54%), Gaps = 3/131 (2%)

Query: 718  SFLALDWDPDLKKRYFDENAAEDFEKHESVEY--KPPKKPFVKLKDCIELFTTKEKLGAE 775
            +++A+DW P      +  +     +KHESVE   +   +P + L  C+  FT++E+LG  
Sbjct: 991  AYIAVDWHPTALHLRYQTSQERVVDKHESVEQSRRAQAEP-INLDSCLRAFTSEEELGES 1049

Query: 776  DPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEF 835
            + +YC  CK H  ATKKLDLW LPP L++HLKRF +      K   +V F     D S F
Sbjct: 1050 EMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQWIKSQKIVRFLRESFDPSAF 1109

Query: 836  LINPNAGPCRY 846
            L+  +   C++
Sbjct: 1110 LVPRDPALCQH 1120



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 33/88 (37%), Positives = 50/88 (56%), Gaps = 1/88 (1%)

Query: 846  YNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQD 905
            YNL A+S H G + GGHY  +AKN  + KWY ++DSS      D+I + +AY+LFY++Q 
Sbjct: 1312 YNLYAISCHSGILSGGHYITYAKN-PNCKWYCYNDSSCEELHPDEIDTDSAYILFYEQQG 1370

Query: 906  TFSGTGFFPLDRETKGASAATGIPLESD 933
                     +D +    +++T    ESD
Sbjct: 1371 IDYAQFLPKIDGKKMADTSSTDEDSESD 1398


>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  196 bits (498), Expect = 9e-50
 Identities = 100/239 (41%), Positives = 142/239 (59%), Gaps = 4/239 (1%)

Query: 214 KNEDGTWPRGPSTPNVKNSNYCLP----SYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTC 269
           + E+   P    T N +N   C P    S  +        P      P L GL NLGNTC
Sbjct: 727 QEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTC 786

Query: 270 FMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVT 329
           +MNS +QCL N P L +YF  + YQ+++N  N LG +GE+A+ +  ++K +W+G++ Y++
Sbjct: 787 YMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYIS 846

Query: 330 PRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVV 389
           P+ FK  +G+   QF+GY QQD QELL FL+DGLHEDLN+   +   + ++ D   D   
Sbjct: 847 PKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKA 906

Query: 390 AEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLE 448
           AE AW+ H + N+SIIV +F G FKST+ C  C K S TF+ F YL+LPL    + TL+
Sbjct: 907 AEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQ 965



 Score =  162 bits (411), Expect = 1e-39
 Identities = 71/143 (49%), Positives = 100/143 (69%)

Query: 759  LKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDK 818
            L+DC+ LF+ +EKL   + +YC +C+  + + KK+++W LPPVL+VHLKRFSY    + K
Sbjct: 964  LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023

Query: 819  LDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYF 878
            L T VDFP+ +LD+S+++I P     +YNL +VSNHYGG+ GGHYTA+ KN    +W+ F
Sbjct: 1024 LQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083

Query: 879  DDSSVSTASEDQIVSKAAYVLFY 901
            DD  VS  S   + S AAY+LFY
Sbjct: 1084 DDHEVSDISVSSVKSSAAYILFY 1106


>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  196 bits (498), Expect = 9e-50
 Identities = 100/239 (41%), Positives = 142/239 (59%), Gaps = 4/239 (1%)

Query: 214 KNEDGTWPRGPSTPNVKNSNYCLP----SYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTC 269
           + E+   P    T N +N   C P    S  +        P      P L GL NLGNTC
Sbjct: 727 QEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTC 786

Query: 270 FMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVT 329
           +MNS +QCL N P L +YF  + YQ+++N  N LG +GE+A+ +  ++K +W+G++ Y++
Sbjct: 787 YMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYIS 846

Query: 330 PRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVV 389
           P+ FK  +G+   QF+GY QQD QELL FL+DGLHEDLN+   +   + ++ D   D   
Sbjct: 847 PKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKA 906

Query: 390 AEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLE 448
           AE AW+ H + N+SIIV +F G FKST+ C  C K S TF+ F YL+LPL    + TL+
Sbjct: 907 AEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQ 965



 Score =  162 bits (411), Expect = 1e-39
 Identities = 71/143 (49%), Positives = 100/143 (69%)

Query: 759  LKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDK 818
            L+DC+ LF+ +EKL   + +YC +C+  + + KK+++W LPPVL+VHLKRFSY    + K
Sbjct: 964  LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023

Query: 819  LDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYF 878
            L T VDFP+ +LD+S+++I P     +YNL +VSNHYGG+ GGHYTA+ KN    +W+ F
Sbjct: 1024 LQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083

Query: 879  DDSSVSTASEDQIVSKAAYVLFY 901
            DD  VS  S   + S AAY+LFY
Sbjct: 1084 DDHEVSDISVSSVKSSAAYILFY 1106


>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  196 bits (498), Expect = 9e-50
 Identities = 100/239 (41%), Positives = 142/239 (59%), Gaps = 4/239 (1%)

Query: 214 KNEDGTWPRGPSTPNVKNSNYCLP----SYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTC 269
           + E+   P    T N +N   C P    S  +        P      P L GL NLGNTC
Sbjct: 727 QEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTC 786

Query: 270 FMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVT 329
           +MNS +QCL N P L +YF  + YQ+++N  N LG +GE+A+ +  ++K +W+G++ Y++
Sbjct: 787 YMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYIS 846

Query: 330 PRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVV 389
           P+ FK  +G+   QF+GY QQD QELL FL+DGLHEDLN+   +   + ++ D   D   
Sbjct: 847 PKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKA 906

Query: 390 AEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLE 448
           AE AW+ H + N+SIIV +F G FKST+ C  C K S TF+ F YL+LPL    + TL+
Sbjct: 907 AEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQ 965



 Score =  162 bits (411), Expect = 1e-39
 Identities = 71/143 (49%), Positives = 100/143 (69%)

Query: 759  LKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDK 818
            L+DC+ LF+ +EKL   + +YC +C+  + + KK+++W LPPVL+VHLKRFSY    + K
Sbjct: 964  LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQK 1023

Query: 819  LDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYF 878
            L T VDFP+ +LD+S+++I P     +YNL +VSNHYGG+ GGHYTA+ KN    +W+ F
Sbjct: 1024 LQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083

Query: 879  DDSSVSTASEDQIVSKAAYVLFY 901
            DD  VS  S   + S AAY+LFY
Sbjct: 1084 DDHEVSDISVSSVKSSAAYILFY 1106


>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
          Length = 396

 Score =  166 bits (419), Expect = 1e-40
 Identities = 90/220 (40%), Positives = 124/220 (56%), Gaps = 11/220 (5%)

Query: 221 PRGPSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSN 280
           PR P +P++  S +        KN        +    GL GL NLGNTCFMNS +QCLSN
Sbjct: 27  PRSPLSPSLLLSTFVGLLLNKAKN--------SKSAQGLAGLRNLGNTCFMNSILQCLSN 78

Query: 281 TPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMW-SGKFSYVTPRAFKTQVGR 339
           T  L +Y L   Y  +L+  +       + + +A+LI+ +W S     V+P  FKTQ+ R
Sbjct: 79  TRELRDYCLQRLYMRDLHHGS--NAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQR 136

Query: 340 FAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLK 399
           +AP+F GY QQD QE L FLLDGLH ++NR+  +P    ++ D  PD     + W  +L+
Sbjct: 137 YAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLE 196

Query: 400 RNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPL 439
           R DS I D+F G  KS+L C +C   S  FDPF  L+LP+
Sbjct: 197 REDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI 236



 Score =  131 bits (329), Expect = 3e-30
 Identities = 65/148 (43%), Positives = 91/148 (61%), Gaps = 1/148 (0%)

Query: 755 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814
           P V L DC+ LFT ++ L  ++   C  C+  ++  KK  +   P +LV+HLKRFS SR 
Sbjct: 242 PEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRI 301

Query: 815 MRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGK 874
              KL T V+FP+ DLD+ EF  + N     YNL AVSNH G   GGHYTA+ ++   G+
Sbjct: 302 RTSKLTTFVNFPLRDLDLREF-ASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGE 360

Query: 875 WYYFDDSSVSTASEDQIVSKAAYVLFYQ 902
           W+ F+DSSV+  S  Q+ +  AY+LFY+
Sbjct: 361 WHTFNDSSVTPMSSSQVRTSDAYLLFYE 388


>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
           sapiens]
          Length = 605

 Score =  166 bits (419), Expect = 1e-40
 Identities = 87/197 (44%), Positives = 117/197 (59%), Gaps = 7/197 (3%)

Query: 248 SEPGRNN----EQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPL 303
           S PGR+        GL GL NLGNTCFMNS +QCLSNT  L +Y L   Y  +L+  +  
Sbjct: 251 SSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGS-- 308

Query: 304 GMRGEIAKSYAELIKQMW-SGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDG 362
                + + +A+LI+ +W S     V+P  FKTQ+ R+AP+F GY QQD QE L FLLDG
Sbjct: 309 NAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDG 368

Query: 363 LHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPEC 422
           LH ++NR+  +P    ++ D  PD     + W  +L+R DS I D+F G  KS+L C +C
Sbjct: 369 LHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDC 428

Query: 423 AKISVTFDPFCYLTLPL 439
              S  FDPF  L+LP+
Sbjct: 429 GYCSTVFDPFWDLSLPI 445



 Score =  131 bits (329), Expect = 3e-30
 Identities = 65/148 (43%), Positives = 91/148 (61%), Gaps = 1/148 (0%)

Query: 755 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814
           P V L DC+ LFT ++ L  ++   C  C+  ++  KK  +   P +LV+HLKRFS SR 
Sbjct: 451 PEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRI 510

Query: 815 MRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGK 874
              KL T V+FP+ DLD+ EF  + N     YNL AVSNH G   GGHYTA+ ++   G+
Sbjct: 511 RTSKLTTFVNFPLRDLDLREF-ASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGE 569

Query: 875 WYYFDDSSVSTASEDQIVSKAAYVLFYQ 902
           W+ F+DSSV+  S  Q+ +  AY+LFY+
Sbjct: 570 WHTFNDSSVTPMSSSQVRTSDAYLLFYE 597


>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
          Length = 1352

 Score =  161 bits (408), Expect = 2e-39
 Identities = 96/281 (34%), Positives = 148/281 (52%), Gaps = 21/281 (7%)

Query: 257 PGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKY-----QEELNFDNPLGM----RG 307
           PG+ GL N GNTCFMN+ +QCLSNT    EY    +Y     +   + + P G     +G
Sbjct: 125 PGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQG 184

Query: 308 EIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDL 367
           E+ +  A L++ +W+ +++    R FKT V + A Q+ G  Q D QE L +LLD +HEDL
Sbjct: 185 EVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDL 244

Query: 368 NRIRKK----PYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECA 423
           N   K+    P     + D  P+                + + ++F   ++S+L CP C 
Sbjct: 245 NHSVKQSGQPPLKPPSETDMMPEGPSFPVC--------STFVQELFQAQYRSSLTCPHCQ 296

Query: 424 KISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSAL 483
           K S TFDPF  ++LP+P+   R L V +V     +  M+  V VP  G +  L  A+S  
Sbjct: 297 KQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSME 356

Query: 484 SGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFE 524
           + IP D++++T++Y   FHR F   ++L ++ E D I+ FE
Sbjct: 357 TKIPTDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFE 397



 Score =  150 bits (378), Expect = 7e-36
 Identities = 80/210 (38%), Positives = 112/210 (53%), Gaps = 25/210 (11%)

Query: 720 LALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKK---PFVKLKDCIELFTTKEKLGAED 776
           L ++WD + +   F     E     ESV  +  +        L  C +L+T +E+L  +D
Sbjct: 556 LVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDD 615

Query: 777 PWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFL 836
            W CP+CK+ QQ +  L LW+LP VL++HLKRF      R KL  +V FP+  LDM+  +
Sbjct: 616 AWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHV 675

Query: 837 INPNA---------GPCR-------------YNLIAVSNHYGGMGGGHYTAFAKNKDDGK 874
           +  +           P R             Y+L AV NH+G M GGHYTA+ KN  DG 
Sbjct: 676 VKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGL 735

Query: 875 WYYFDDSSVSTASEDQIVSKAAYVLFYQRQ 904
           WY FDDS V   SED++ ++ AY+LFYQR+
Sbjct: 736 WYCFDDSDVQQLSEDEVCTQTAYILFYQRR 765


>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
          Length = 1123

 Score =  159 bits (403), Expect = 9e-39
 Identities = 90/285 (31%), Positives = 149/285 (52%), Gaps = 12/285 (4%)

Query: 251 GRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIA 310
           G     PG  GL N GNTCFMN+ +QCLSNT  L E+    +Y+           R E+ 
Sbjct: 92  GDGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPG-------RAEVT 144

Query: 311 KSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRI 370
           +  A L++ +W+ +++      FK  V ++  QF G  Q D  E L +LLD +HEDL   
Sbjct: 145 EQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGS 204

Query: 371 RKKPYIQL--KDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVT 428
            + P  +    +A    +  ++  A    L    S +   F   ++S+L CP C K S T
Sbjct: 205 SRGPVSEKLPPEATKTSENCLSPSA---QLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNT 261

Query: 429 FDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPA 488
           FDPF  ++LP+P+++ R L V LV      + ++  + VP +  +  L   ++   G+PA
Sbjct: 262 FDPFLCVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPA 321

Query: 489 DKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDT 533
           D++I+ ++Y   F R F  +E+L++I E D++Y F++  + ++ T
Sbjct: 322 DEVILVELYPSGFQRSFFDEEDLNTIAEGDNVYAFQVPPSPSQGT 366



 Score =  152 bits (384), Expect = 1e-36
 Identities = 77/212 (36%), Positives = 123/212 (58%), Gaps = 25/212 (11%)

Query: 720 LALDWDPDLKKRYFDENAAEDFEKHESV--EYKPPKKPFVKLKDCIELFTTKEKLGAEDP 777
           LA++WD  +K+R F     E  +  +SV  + +  ++    L +C + +T +E+L  +D 
Sbjct: 501 LAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDA 560

Query: 778 WYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFL- 836
           W CP+C+  QQ   KL LW+LP +L++HLKRF      R+KL TLV FP++ L+M+  + 
Sbjct: 561 WKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVA 620

Query: 837 ---INPNAG-------------------PCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGK 874
               +P AG                      Y+L AV NH+G + GGHYTA+ +N  DG+
Sbjct: 621 QRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQ 680

Query: 875 WYYFDDSSVSTASEDQIVSKAAYVLFYQRQDT 906
           WY +DDS+V    ED++ ++ AY+LFYQ++++
Sbjct: 681 WYSYDDSTVEPLREDEVNTRGAYILFYQKRNS 712


>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
          Length = 520

 Score =  141 bits (355), Expect = 3e-33
 Identities = 69/160 (43%), Positives = 106/160 (66%), Gaps = 6/160 (3%)

Query: 755 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814
           P   L+DC+  FT  E+L   + + C  CK+ Q++TKK  +  LP VL +HLKRF ++ Y
Sbjct: 360 PVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAY 419

Query: 815 MRDKLDTLVDFPINDLDMSEFLINP-NAGP--CRYNLIAVSNHYG-GMGGGHYTAFAKNK 870
           +R+K+DT V+FP+  LDM  +L+ P N+GP  C Y+L AV  H+G G+G GHYTA+A + 
Sbjct: 420 LRNKVDTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATH- 478

Query: 871 DDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQDTFSGT 910
            +G+W++F+DS+V+   E+ +V   AY+LFY      +G+
Sbjct: 479 -EGRWFHFNDSTVTLTDEETVVKAKAYILFYVEHQAKAGS 517



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 63/208 (30%), Positives = 89/208 (42%), Gaps = 32/208 (15%)

Query: 253 NNEQPGLC--GLSNLGNTCFMNSAIQCLSNTPPLTEYFL--------NDK------YQEE 296
           N     +C  GL NLGNTCFMN+ +Q LSN      YF         N K      Y   
Sbjct: 150 NGSTTAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTR 209

Query: 297 LNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELL 356
              DN + +  E  K+   L    W G  +  +P +    V +  P F GYQQQD  E +
Sbjct: 210 SQGDNNVSLVEEFRKTLCAL----WQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFM 265

Query: 357 AFLLDGLHEDL----NRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGL 412
            +LLD LH +L    N + +   +Q        +K     A         +++  IF G+
Sbjct: 266 RYLLDHLHLELQGGFNGVSRSAILQENSTLSASNKCCINGA--------STVVTAIFGGI 317

Query: 413 FKSTLVCPECAKISVTFDPFCYLTLPLP 440
            ++ + C  C   S  FDPF  L+L +P
Sbjct: 318 LQNEVNCLICGTESRKFDPFLDLSLDIP 345


>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score =  128 bits (321), Expect = 3e-29
 Identities = 77/202 (38%), Positives = 111/202 (54%), Gaps = 21/202 (10%)

Query: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRG-EIAKSYAEL 316
           G  GL NLGNTCF+N+ +QCLS+T PL ++ L   +++E+    P G R  E+ +++A++
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEV----PGGGRAQELTEAFADV 265

Query: 317 IKQMWS-GKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRI-RKKP 374
           I  +W       V P  F+    ++ P FSGY QQD QE L  L++ LH ++NR  R+ P
Sbjct: 266 IGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAP 325

Query: 375 YIQLKDADGRPDK---VVAEEA-----------WENHLKRNDSIIVDIFHGLFKSTLVCP 420
            I        P +    + EE            W+ +L+R DS IVD+F G  KS L C 
Sbjct: 326 PILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQ 385

Query: 421 ECAKISVTFDPFCYLTLPLPMK 442
            C   S TF+ FC L+LP+P K
Sbjct: 386 ACGYRSTTFEVFCDLSLPIPKK 407



 Score =  116 bits (290), Expect = 1e-25
 Identities = 65/155 (41%), Positives = 90/155 (58%), Gaps = 7/155 (4%)

Query: 752 PKKPF----VKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLK 807
           PKK F    V L+DC  LFT +E+L +E+   C  C++  ++TKKL +   P +LV+HL 
Sbjct: 405 PKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLN 464

Query: 808 RFSYSRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFA 867
           RFS SR    K    VDFP+  L + +F  +  AG   Y L A+ NH G +  GHYTA  
Sbjct: 465 RFSASRGSIKKSSVGVDFPLQRLSLGDF-ASDKAGSPVYQLYALCNHSGSVHYGHYTALC 523

Query: 868 KNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQ 902
           + +    W+ ++DS VS  SE+Q+ S   YVLFYQ
Sbjct: 524 RCQTG--WHVYNDSRVSPVSENQVASSEGYVLFYQ 556


>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score =  128 bits (321), Expect = 3e-29
 Identities = 77/202 (38%), Positives = 111/202 (54%), Gaps = 21/202 (10%)

Query: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRG-EIAKSYAEL 316
           G  GL NLGNTCF+N+ +QCLS+T PL ++ L   +++E+    P G R  E+ +++A++
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEV----PGGGRAQELTEAFADV 265

Query: 317 IKQMWS-GKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRI-RKKP 374
           I  +W       V P  F+    ++ P FSGY QQD QE L  L++ LH ++NR  R+ P
Sbjct: 266 IGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAP 325

Query: 375 YIQLKDADGRPDK---VVAEEA-----------WENHLKRNDSIIVDIFHGLFKSTLVCP 420
            I        P +    + EE            W+ +L+R DS IVD+F G  KS L C 
Sbjct: 326 PILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQ 385

Query: 421 ECAKISVTFDPFCYLTLPLPMK 442
            C   S TF+ FC L+LP+P K
Sbjct: 386 ACGYRSTTFEVFCDLSLPIPKK 407



 Score =  116 bits (290), Expect = 1e-25
 Identities = 65/155 (41%), Positives = 90/155 (58%), Gaps = 7/155 (4%)

Query: 752 PKKPF----VKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLK 807
           PKK F    V L+DC  LFT +E+L +E+   C  C++  ++TKKL +   P +LV+HL 
Sbjct: 405 PKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLN 464

Query: 808 RFSYSRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFA 867
           RFS SR    K    VDFP+  L + +F  +  AG   Y L A+ NH G +  GHYTA  
Sbjct: 465 RFSASRGSIKKSSVGVDFPLQRLSLGDF-ASDKAGSPVYQLYALCNHSGSVHYGHYTALC 523

Query: 868 KNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQ 902
           + +    W+ ++DS VS  SE+Q+ S   YVLFYQ
Sbjct: 524 RCQTG--WHVYNDSRVSPVSENQVASSEGYVLFYQ 556


>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
          Length = 828

 Score =  110 bits (275), Expect = 6e-24
 Identities = 53/150 (35%), Positives = 84/150 (56%), Gaps = 1/150 (0%)

Query: 755 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814
           P V L+DC+  F  +++L  ++ + C  CK+ +   K   + + P +L +HLKRF +   
Sbjct: 557 PVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELM 616

Query: 815 MRDKLDTLVDFPINDLDMSEFLINPN-AGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDG 873
              K+ T V FP+  LD+  FL   + A    Y+L++V  H+G    GHY A+ +N  + 
Sbjct: 617 FSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNN 676

Query: 874 KWYYFDDSSVSTASEDQIVSKAAYVLFYQR 903
            WY FDD SV+  SE  + +  AYVLFY++
Sbjct: 677 LWYEFDDQSVTEVSESTVQNAEAYVLFYRK 706



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 52/146 (35%), Positives = 75/146 (51%), Gaps = 14/146 (9%)

Query: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELI 317
           GL GL N+GNTC+MN+A+Q LSN PPLT++FL+       +       +  I KSY +L+
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTD------KKPAICKSYLKLM 236

Query: 318 KQMW-SGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYI 376
            ++W   +   V P      +    P F GY QQD QE L  L+D LHE+L         
Sbjct: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE------- 289

Query: 377 QLKDADGRPDKVVAEEAWENHLKRND 402
           Q+ + +  P  +  EE  E    ++D
Sbjct: 290 QVMEVEEDPQTITTEETMEEDKSQSD 315



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 19/46 (41%), Positives = 30/46 (65%)

Query: 399 KRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKE 444
           K+  S+I DIF G   S++ C  C ++SVT + F  L+LP+P K++
Sbjct: 469 KKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514


>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
          Length = 942

 Score =  110 bits (275), Expect = 6e-24
 Identities = 53/150 (35%), Positives = 84/150 (56%), Gaps = 1/150 (0%)

Query: 755 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814
           P V L+DC+  F  +++L  ++ + C  CK+ +   K   + + P +L +HLKRF +   
Sbjct: 565 PVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELM 624

Query: 815 MRDKLDTLVDFPINDLDMSEFLINPN-AGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDG 873
              K+ T V FP+  LD+  FL   + A    Y+L++V  H+G    GHY A+ +N  + 
Sbjct: 625 FSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNN 684

Query: 874 KWYYFDDSSVSTASEDQIVSKAAYVLFYQR 903
            WY FDD SV+  SE  + +  AYVLFY++
Sbjct: 685 LWYEFDDQSVTEVSESTVQNAEAYVLFYRK 714



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 52/146 (35%), Positives = 75/146 (51%), Gaps = 14/146 (9%)

Query: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELI 317
           GL GL N+GNTC+MN+A+Q LSN PPLT++FL+       +       +  I KSY +L+
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTD------KKPAICKSYLKLM 236

Query: 318 KQMW-SGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYI 376
            ++W   +   V P      +    P F GY QQD QE L  L+D LHE+L         
Sbjct: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE------- 289

Query: 377 QLKDADGRPDKVVAEEAWENHLKRND 402
           Q+ + +  P  +  EE  E    ++D
Sbjct: 290 QVMEVEEDPQTITTEETMEEDKSQSD 315



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 19/46 (41%), Positives = 30/46 (65%)

Query: 399 KRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKE 444
           K+  S+I DIF G   S++ C  C ++SVT + F  L+LP+P K++
Sbjct: 469 KKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514



 Score = 33.9 bits (76), Expect = 0.74
 Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 19/95 (20%)

Query: 15  DIATLLKTSLRKGD---TWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNS--G 69
           +I   L  + +K D   T+Y +  +WF++W+ +V      K + GD    PGPIDN+   
Sbjct: 829 EIFIRLNRAFQKEDSPATFYCISMQWFREWESFV------KGKDGDP---PGPIDNTKIA 879

Query: 70  LLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWY 104
           + K G+       L    D   +  E WN L S Y
Sbjct: 880 VTKCGNVM-----LRQGADSGQISEETWNFLQSIY 909


>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
          Length = 911

 Score =  110 bits (275), Expect = 6e-24
 Identities = 53/150 (35%), Positives = 84/150 (56%), Gaps = 1/150 (0%)

Query: 755 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814
           P V L+DC+  F  +++L  ++ + C  CK+ +   K   + + P +L +HLKRF +   
Sbjct: 534 PVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELM 593

Query: 815 MRDKLDTLVDFPINDLDMSEFLINPN-AGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDG 873
              K+ T V FP+  LD+  FL   + A    Y+L++V  H+G    GHY A+ +N  + 
Sbjct: 594 FSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNN 653

Query: 874 KWYYFDDSSVSTASEDQIVSKAAYVLFYQR 903
            WY FDD SV+  SE  + +  AYVLFY++
Sbjct: 654 LWYEFDDQSVTEVSESTVQNAEAYVLFYRK 683



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 52/146 (35%), Positives = 75/146 (51%), Gaps = 14/146 (9%)

Query: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELI 317
           GL GL N+GNTC+MN+A+Q LSN PPLT++FL+       +       +  I KSY +L+
Sbjct: 152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTD------KKPAICKSYLKLM 205

Query: 318 KQMW-SGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYI 376
            ++W   +   V P      +    P F GY QQD QE L  L+D LHE+L         
Sbjct: 206 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE------- 258

Query: 377 QLKDADGRPDKVVAEEAWENHLKRND 402
           Q+ + +  P  +  EE  E    ++D
Sbjct: 259 QVMEVEEDPQTITTEETMEEDKSQSD 284



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 19/46 (41%), Positives = 30/46 (65%)

Query: 399 KRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKE 444
           K+  S+I DIF G   S++ C  C ++SVT + F  L+LP+P K++
Sbjct: 438 KKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 483



 Score = 33.9 bits (76), Expect = 0.74
 Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 19/95 (20%)

Query: 15  DIATLLKTSLRKGD---TWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNS--G 69
           +I   L  + +K D   T+Y +  +WF++W+ +V      K + GD    PGPIDN+   
Sbjct: 798 EIFIRLNRAFQKEDSPATFYCISMQWFREWESFV------KGKDGDP---PGPIDNTKIA 848

Query: 70  LLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWY 104
           + K G+       L    D   +  E WN L S Y
Sbjct: 849 VTKCGNVM-----LRQGADSGQISEETWNFLQSIY 878


>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
          Length = 711

 Score =  104 bits (260), Expect = 3e-22
 Identities = 56/162 (34%), Positives = 92/162 (56%), Gaps = 20/162 (12%)

Query: 759 LKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDK 818
           L DC++ FT  E LG+     C +C+ +Q++TK+L +  LP V   HLKRF +    R K
Sbjct: 549 LTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRRK 608

Query: 819 LDTLVDFPINDLDMSEFLIN----------------PNAGPCRYNLIAVSNHYGGMGGGH 862
           ++T + FP+ +LDM+ FL +                PN    +Y+L AV NH+G +  GH
Sbjct: 609 INTFISFPL-ELDMTPFLASTKESRMKEGQPPTDCVPNEN--KYSLFAVINHHGTLESGH 665

Query: 863 YTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQ 904
           YT+F + + D +W+  DD+ ++ A+ + ++    Y+LFY +Q
Sbjct: 666 YTSFIRQQKD-QWFSCDDAIITKATIEDLLYSEGYLLFYHKQ 706



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 59/183 (32%), Positives = 85/183 (46%), Gaps = 24/183 (13%)

Query: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELI 317
           GL GL NLGNTCFMN  +Q L++ P L ++FL+DK++  +   +       +    + L 
Sbjct: 361 GLRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLC-----LVCEMSSLF 415

Query: 318 KQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQ 377
             M+SG  +   P      +   A   +GY+QQD  E L  +LD LH             
Sbjct: 416 HAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHR-----------H 464

Query: 378 LKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTL 437
            KD  G       +EA  N+    + II  IF G  +S + C  C  +S T DP   ++L
Sbjct: 465 SKDDSG------GQEA--NNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISL 516

Query: 438 PLP 440
            LP
Sbjct: 517 DLP 519


>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score =  104 bits (259), Expect = 4e-22
 Identities = 51/150 (34%), Positives = 83/150 (55%), Gaps = 1/150 (0%)

Query: 755 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814
           P V L+DC+  F   ++L  ++ + C  CK+ +   K   +  LP +L +HLKRF +   
Sbjct: 535 PVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVM 594

Query: 815 MRDKLDTLVDFPINDLDMSEFLINP-NAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDG 873
              K+++ V FP+  LD+  FL     +    Y+L++V  H+G  G GHY A+ +N  +G
Sbjct: 595 YSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVING 654

Query: 874 KWYYFDDSSVSTASEDQIVSKAAYVLFYQR 903
           +WY FDD  V+   E  + +   YVLFY++
Sbjct: 655 QWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 48/111 (43%), Positives = 65/111 (58%), Gaps = 7/111 (6%)

Query: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELI 317
           GL G+ NLGN+C+MN+A+Q LSN PPLT++FL      E         +  + KSY +L+
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL------ECGGLVRTDKKPALCKSYQKLV 196

Query: 318 KQMWSGKF-SYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDL 367
            ++W  K  SYV P +    +    P F GY QQD QE L  L+D LHE+L
Sbjct: 197 SEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247



 Score = 38.5 bits (88), Expect = 0.030
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 5/75 (6%)

Query: 370 IRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTF 429
           +R  P   LK A     +V++  +     +R  S+I DIF G   S + C  C ++S T 
Sbjct: 415 VRMAPSYVLKKA-----QVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTV 469

Query: 430 DPFCYLTLPLPMKKE 444
           + F  L+LP+P K++
Sbjct: 470 ETFQDLSLPIPGKED 484



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 15/76 (19%)

Query: 31  YLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGL--LKDGDAQSLKEHLIDELD 88
           Y +  +WF++W+ +V          G  N  PGPIDNS +  +K      LK+      D
Sbjct: 818 YCISMQWFREWEAFV---------KGKDNEPPGPIDNSRIAQVKGSGHVQLKQ----GAD 864

Query: 89  YILLPTEGWNKLVSWY 104
           Y  +  E W  L S Y
Sbjct: 865 YGQISEETWTYLNSLY 880


>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score =  104 bits (259), Expect = 4e-22
 Identities = 51/150 (34%), Positives = 83/150 (55%), Gaps = 1/150 (0%)

Query: 755 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814
           P V L+DC+  F   ++L  ++ + C  CK+ +   K   +  LP +L +HLKRF +   
Sbjct: 535 PVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVM 594

Query: 815 MRDKLDTLVDFPINDLDMSEFLINP-NAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDG 873
              K+++ V FP+  LD+  FL     +    Y+L++V  H+G  G GHY A+ +N  +G
Sbjct: 595 YSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVING 654

Query: 874 KWYYFDDSSVSTASEDQIVSKAAYVLFYQR 903
           +WY FDD  V+   E  + +   YVLFY++
Sbjct: 655 QWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 48/111 (43%), Positives = 65/111 (58%), Gaps = 7/111 (6%)

Query: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELI 317
           GL G+ NLGN+C+MN+A+Q LSN PPLT++FL      E         +  + KSY +L+
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL------ECGGLVRTDKKPALCKSYQKLV 196

Query: 318 KQMWSGKF-SYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDL 367
            ++W  K  SYV P +    +    P F GY QQD QE L  L+D LHE+L
Sbjct: 197 SEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247



 Score = 38.5 bits (88), Expect = 0.030
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 5/75 (6%)

Query: 370 IRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTF 429
           +R  P   LK A     +V++  +     +R  S+I DIF G   S + C  C ++S T 
Sbjct: 415 VRMAPSYVLKKA-----QVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTV 469

Query: 430 DPFCYLTLPLPMKKE 444
           + F  L+LP+P K++
Sbjct: 470 ETFQDLSLPIPGKED 484



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 15/76 (19%)

Query: 31  YLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGL--LKDGDAQSLKEHLIDELD 88
           Y +  +WF++W+ +V          G  N  PGPIDNS +  +K      LK+      D
Sbjct: 818 YCISMQWFREWEAFV---------KGKDNEPPGPIDNSRIAQVKGSGHVQLKQ----GAD 864

Query: 89  YILLPTEGWNKLVSWY 104
           Y  +  E W  L S Y
Sbjct: 865 YGQISEETWTYLNSLY 880


>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score =  104 bits (259), Expect = 4e-22
 Identities = 51/150 (34%), Positives = 83/150 (55%), Gaps = 1/150 (0%)

Query: 755 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814
           P V L+DC+  F   ++L  ++ + C  CK+ +   K   +  LP +L +HLKRF +   
Sbjct: 535 PVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVM 594

Query: 815 MRDKLDTLVDFPINDLDMSEFLINP-NAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDG 873
              K+++ V FP+  LD+  FL     +    Y+L++V  H+G  G GHY A+ +N  +G
Sbjct: 595 YSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVING 654

Query: 874 KWYYFDDSSVSTASEDQIVSKAAYVLFYQR 903
           +WY FDD  V+   E  + +   YVLFY++
Sbjct: 655 QWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 48/111 (43%), Positives = 65/111 (58%), Gaps = 7/111 (6%)

Query: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELI 317
           GL G+ NLGN+C+MN+A+Q LSN PPLT++FL      E         +  + KSY +L+
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL------ECGGLVRTDKKPALCKSYQKLV 196

Query: 318 KQMWSGKF-SYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDL 367
            ++W  K  SYV P +    +    P F GY QQD QE L  L+D LHE+L
Sbjct: 197 SEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEEL 247



 Score = 38.5 bits (88), Expect = 0.030
 Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 5/75 (6%)

Query: 370 IRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTF 429
           +R  P   LK A     +V++  +     +R  S+I DIF G   S + C  C ++S T 
Sbjct: 415 VRMAPSYVLKKA-----QVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTV 469

Query: 430 DPFCYLTLPLPMKKE 444
           + F  L+LP+P K++
Sbjct: 470 ETFQDLSLPIPGKED 484



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 15/76 (19%)

Query: 31  YLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGL--LKDGDAQSLKEHLIDELD 88
           Y +  +WF++W+ +V          G  N  PGPIDNS +  +K      LK+      D
Sbjct: 818 YCISMQWFREWEAFV---------KGKDNEPPGPIDNSRIAQVKGSGHVQLKQ----GAD 864

Query: 89  YILLPTEGWNKLVSWY 104
           Y  +  E W  L S Y
Sbjct: 865 YGQISEETWTYLNSLY 880


>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
          Length = 525

 Score =  103 bits (256), Expect = 1e-21
 Identities = 56/161 (34%), Positives = 85/161 (52%), Gaps = 17/161 (10%)

Query: 759 LKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDK 818
           L DC+  FT  E LG+     C  C  +Q++TK+L +  LP V   HLKRF +S  +R K
Sbjct: 362 LTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRRK 421

Query: 819 LDTLVDFPINDLDMSEFLINPNAGPC---------------RYNLIAVSNHYGGMGGGHY 863
           + T V FP+ +LDM+ F+ +                     +Y+L AV NH G +  GHY
Sbjct: 422 ITTYVSFPL-ELDMTPFMASSKESRMNGQYQQPTDSLNNDNKYSLFAVVNHQGTLESGHY 480

Query: 864 TAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQ 904
           T+F +   D +W+  DD+ ++ AS   ++    Y+LFY +Q
Sbjct: 481 TSFIRQHKD-QWFKCDDAIITKASIKDVLDSEGYLLFYHKQ 520



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 59/183 (32%), Positives = 86/183 (46%), Gaps = 24/183 (13%)

Query: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELI 317
           GL GL NLGNTCFMN  +Q L++TP L ++FL+D+++ E+   +       +    + L 
Sbjct: 174 GLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSC-----LVCEMSSLF 228

Query: 318 KQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQ 377
           ++ +SG  S   P      V   A   +GY+QQD  E L   LD LH             
Sbjct: 229 QEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCK--------- 279

Query: 378 LKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTL 437
             D +G+           N+    + II  IF G  +S + C  C  +S T DPF  ++L
Sbjct: 280 -GDDNGKK---------ANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISL 329

Query: 438 PLP 440
            LP
Sbjct: 330 DLP 332


>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
          Length = 438

 Score =  102 bits (255), Expect = 1e-21
 Identities = 55/161 (34%), Positives = 86/161 (53%), Gaps = 17/161 (10%)

Query: 759 LKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDK 818
           L DC+  FT  E LG+     C +C+ +Q++TK+L +  LP V   H KRF +S   R K
Sbjct: 263 LTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRK 322

Query: 819 LDTLVDFPINDLDMSEFL---------------INPNAGPCRYNLIAVSNHYGGMGGGHY 863
           + T + FP+ +LDM+ F+                N      +Y+L AV NH G +  GHY
Sbjct: 323 ITTYISFPL-ELDMTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHY 381

Query: 864 TAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQ 904
           T+F ++  D +W+  DD+ ++ AS   ++    Y+LFY +Q
Sbjct: 382 TSFIRHHKD-QWFKCDDAVITKASIKDVLDSEGYLLFYHKQ 421



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 59/188 (31%), Positives = 86/188 (45%), Gaps = 34/188 (18%)

Query: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELI 317
           GL GL NLGNTCFMN  +Q L++TP L ++FL+D+++ E+           +    + L 
Sbjct: 76  GLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELC-----LVCEMSSLF 130

Query: 318 KQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLH-----EDLNRIRK 372
           ++++SG  S   P      V   A   +GY+QQD  E L   LD LH     +D+ +   
Sbjct: 131 RELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAAN 190

Query: 373 KPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPF 432
            P                     NH    + II  IF G  +S + C  C  +S T DP 
Sbjct: 191 NP---------------------NHC---NCIIDQIFTGGLQSDVTCQACHGVSTTIDPC 226

Query: 433 CYLTLPLP 440
             ++L LP
Sbjct: 227 WDISLDLP 234


>gi|45267835 ubiquitin specific protease 50 [Homo sapiens]
          Length = 339

 Score =  101 bits (252), Expect = 3e-21
 Identities = 64/193 (33%), Positives = 93/193 (48%), Gaps = 13/193 (6%)

Query: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELI 317
           G+ GL NLGNTC +N+  QCL +  PL EYFL  KY   L          E+A ++A L+
Sbjct: 42  GVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLPSDCSEVATAFAYLM 101

Query: 318 KQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRI---RKKP 374
             MW G    V+P  F + +G   P F+   QQD QE L  +L+ LHE L +    R++ 
Sbjct: 102 TDMWLGDSDCVSPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKYHYSRRRS 161

Query: 375 YIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCY 434
           Y          +K   +      +    SII  +F      ++VC +C K +   + F  
Sbjct: 162 Y----------EKGSTQRCCRKWITTETSIITQLFEEQLNYSIVCLKCEKCTYKNEVFTV 211

Query: 435 LTLPLPMKKERTL 447
            +LP+P K E +L
Sbjct: 212 FSLPIPSKYECSL 224



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 39/118 (33%), Positives = 66/118 (55%)

Query: 752 PKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSY 811
           P K    L+DC++ F  ++ L   +  +C  C+  Q+   +  +   P +++ HLKRF  
Sbjct: 217 PSKYECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDI 276

Query: 812 SRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKN 869
               + KL T + +P+ +LD++ ++ +      +YNL AV NH+G + GGHYTAF KN
Sbjct: 277 QGTTKRKLRTDIHYPLTNLDLTPYICSIFRKYPKYNLCAVVNHFGDLDGGHYTAFCKN 334


>gi|239751420 PREDICTED: similar to hCG2039376 [Homo sapiens]
          Length = 858

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 45/84 (53%), Positives = 62/84 (73%), Gaps = 2/84 (2%)

Query: 256 QPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAE 315
           + G  GLSNLGNTCFMNS+IQC+SNT PLT+YF++ ++  ELN  NP+GM+G +AK Y +
Sbjct: 775 EKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGD 834

Query: 316 LIKQMWSGKFSYVTPRAFKTQVGR 339
           L++++WSG    V P   K +V R
Sbjct: 835 LVQELWSGTQKNVAP--LKLRVSR 856



 Score = 38.5 bits (88), Expect = 0.030
 Identities = 18/64 (28%), Positives = 30/64 (46%), Gaps = 6/64 (9%)

Query: 24  LRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHL 83
           L+ G  W+++  +W++QWK+YV      KY      + P  + N G    G A    E +
Sbjct: 458 LQAGHNWFIISMQWWQQWKEYV------KYDANPVVIEPSSVLNGGKYSFGTAAHPMEQV 511

Query: 84  IDEL 87
            D +
Sbjct: 512 EDRI 515


>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
          Length = 822

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 64/193 (33%), Positives = 99/193 (51%), Gaps = 14/193 (7%)

Query: 261 GLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQ--------EELNFDNPLGMR----GE 308
           GLSNLGNTCF N+ +Q LS TP L E     K           +L    PL +     G 
Sbjct: 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGP 255

Query: 309 IAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLH-EDL 367
           +  + ++ + +M   K   VTP+   +QV + A +F GYQQQD QELL +LLDG+  E+ 
Sbjct: 256 LTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEH 315

Query: 368 NRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVD-IFHGLFKSTLVCPECAKIS 426
            R+ K       ++  + D+ +  +  +   K++    VD IF G   S ++C +C  +S
Sbjct: 316 QRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVS 375

Query: 427 VTFDPFCYLTLPL 439
           +  + F  L+LP+
Sbjct: 376 LVHESFLDLSLPV 388



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 49/190 (25%), Positives = 78/190 (41%), Gaps = 46/190 (24%)

Query: 759 LKDCIELFTTKEKLGAEDPWYCPNCKEHQ-----------------QATKKLDLWSLPPV 801
           ++ C+  FT  EKL   +   C  C   Q                  A K++ +   PPV
Sbjct: 632 IQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPPV 691

Query: 802 LVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFL------INPNAGPCRYNLIAVSNHY 855
           L +HLKRF  + +   K++  + FP   LD++ F       +        Y+L  V  H 
Sbjct: 692 LTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTRVLYSLYGVVEHS 750

Query: 856 GGMGGGHYTAFAKNK----------------------DDGKWYYFDDSSVSTASEDQIVS 893
           G M  GHYTA+AK +                        G+W++  D+ V      ++++
Sbjct: 751 GTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLN 810

Query: 894 KAAYVLFYQR 903
             AY+LFY+R
Sbjct: 811 SQAYLLFYER 820


>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
          Length = 823

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 64/193 (33%), Positives = 99/193 (51%), Gaps = 14/193 (7%)

Query: 261 GLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQ--------EELNFDNPLGMR----GE 308
           GLSNLGNTCF N+ +Q LS TP L E     K           +L    PL +     G 
Sbjct: 197 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGP 256

Query: 309 IAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLH-EDL 367
           +  + ++ + +M   K   VTP+   +QV + A +F GYQQQD QELL +LLDG+  E+ 
Sbjct: 257 LTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEH 316

Query: 368 NRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVD-IFHGLFKSTLVCPECAKIS 426
            R+ K       ++  + D+ +  +  +   K++    VD IF G   S ++C +C  +S
Sbjct: 317 QRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVS 376

Query: 427 VTFDPFCYLTLPL 439
           +  + F  L+LP+
Sbjct: 377 LVHESFLDLSLPV 389



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 49/190 (25%), Positives = 78/190 (41%), Gaps = 46/190 (24%)

Query: 759 LKDCIELFTTKEKLGAEDPWYCPNCKEHQ-----------------QATKKLDLWSLPPV 801
           ++ C+  FT  EKL   +   C  C   Q                  A K++ +   PPV
Sbjct: 633 IQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPPV 692

Query: 802 LVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFL------INPNAGPCRYNLIAVSNHY 855
           L +HLKRF  + +   K++  + FP   LD++ F       +        Y+L  V  H 
Sbjct: 693 LTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTRVLYSLYGVVEHS 751

Query: 856 GGMGGGHYTAFAKNK----------------------DDGKWYYFDDSSVSTASEDQIVS 893
           G M  GHYTA+AK +                        G+W++  D+ V      ++++
Sbjct: 752 GTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLN 811

Query: 894 KAAYVLFYQR 903
             AY+LFY+R
Sbjct: 812 SQAYLLFYER 821


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,201,443
Number of Sequences: 37866
Number of extensions: 1896692
Number of successful extensions: 7267
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 132
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 6339
Number of HSP's gapped (non-prelim): 686
length of query: 952
length of database: 18,247,518
effective HSP length: 112
effective length of query: 840
effective length of database: 14,006,526
effective search space: 11765481840
effective search space used: 11765481840
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.