Search of human proteins with 88758576

Search of human proteins with 88758576

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|88758576 Shaw-related voltage-gated potassium channel
protein 4 isoform c [Homo sapiens]
         (626 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|88758576 Shaw-related voltage-gated potassium channel protein...  1280   0.0  
gi|24497462 Shaw-related voltage-gated potassium channel protein...  1243   0.0  
gi|24497464 Shaw-related voltage-gated potassium channel protein...  1108   0.0  
gi|21217561 Shaw-related voltage-gated potassium channel protein...   802   0.0  
gi|163792201 Shaw-related voltage-gated potassium channel protei...   796   0.0  
gi|21217563 Shaw-related voltage-gated potassium channel protein...   787   0.0  
gi|4826786 Shaw-related voltage-gated potassium channel protein ...   751   0.0  
gi|24497458 Shaw-related voltage-gated potassium channel protein...   742   0.0  
gi|24497460 Shaw-related voltage-gated potassium channel protein...   715   0.0  
gi|4826784 potassium voltage-gated channel, Shab-related subfami...   299   6e-81
gi|27436974 potassium voltage-gated channel, Shab-related subfam...   297   2e-80
gi|119395748 potassium voltage-gated channel subfamily A member ...   271   2e-72
gi|27436981 potassium voltage-gated channel, Shal-related subfam...   264   2e-70
gi|25952092 potassium voltage-gated channel, shaker-related subf...   261   1e-69
gi|9789987 potassium voltage-gated channel, Shal-related subfami...   261   1e-69
gi|4504817 potassium voltage-gated channel, shaker-related subfa...   260   2e-69
gi|5031819 potassium voltage-gated channel, shaker-related subfa...   260   2e-69
gi|4826782 potassium voltage-gated channel, shaker-related subfa...   258   1e-68
gi|88758565 potassium voltage-gated channel, shaker-related subf...   255   1e-67
gi|27436986 potassium voltage-gated channel, Shal-related subfam...   254   1e-67
gi|4504821 potassium voltage-gated channel, shaker-related subfa...   254   2e-67
gi|27436984 potassium voltage-gated channel, Shal-related subfam...   250   2e-66
gi|25952087 potassium voltage-gated channel, shaker-related subf...   246   6e-65
gi|25952108 potassium voltage-gated channel delayed-rectifier pr...   241   1e-63
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]    240   3e-63
gi|20070166 potassium voltage-gated channel, subfamily F, member...   236   4e-62
gi|13492973 potassium voltage-gated channel delayed-rectifier pr...   231   2e-60
gi|27436988 potassium voltage-gated channel, subfamily G, member...   216   4e-56
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ...   213   6e-55
gi|27436993 potassium voltage-gated channel, subfamily G, member...   210   3e-54

>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
           isoform c [Homo sapiens]
          Length = 626

 Score = 1280 bits (3311), Expect = 0.0
 Identities = 626/626 (100%), Positives = 626/626 (100%)

Query: 1   MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT 60
           MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT
Sbjct: 1   MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT 60

Query: 61  RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD 120
           RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD
Sbjct: 61  RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD 120

Query: 121 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD 180
           VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD
Sbjct: 121 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD 180

Query: 181 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI 240
           ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI
Sbjct: 181 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI 240

Query: 241 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI 300
           TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI
Sbjct: 241 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI 300

Query: 301 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL 360
           VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL
Sbjct: 301 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL 360

Query: 361 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF 420
           TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF
Sbjct: 361 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF 420

Query: 421 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS 480
           KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS
Sbjct: 421 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS 480

Query: 481 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADS 540
           LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADS
Sbjct: 481 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADS 540

Query: 541 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA 600
           KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA
Sbjct: 541 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA 600

Query: 601 DGSVRKETCQDALSSNYAQAEVLTLS 626
           DGSVRKETCQDALSSNYAQAEVLTLS
Sbjct: 601 DGSVRKETCQDALSSNYAQAEVLTLS 626


>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
           isoform a [Homo sapiens]
          Length = 635

 Score = 1243 bits (3216), Expect = 0.0
 Identities = 607/608 (99%), Positives = 607/608 (99%)

Query: 1   MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT 60
           MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT
Sbjct: 1   MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT 60

Query: 61  RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD 120
           RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD
Sbjct: 61  RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD 120

Query: 121 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD 180
           VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD
Sbjct: 121 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD 180

Query: 181 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI 240
           ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI
Sbjct: 181 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI 240

Query: 241 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI 300
           TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI
Sbjct: 241 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI 300

Query: 301 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL 360
           VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL
Sbjct: 301 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL 360

Query: 361 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF 420
           TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF
Sbjct: 361 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF 420

Query: 421 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS 480
           KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS
Sbjct: 421 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS 480

Query: 481 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADS 540
           LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADS
Sbjct: 481 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADS 540

Query: 541 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA 600
           KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA
Sbjct: 541 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA 600

Query: 601 DGSVRKET 608
           DGSVRK T
Sbjct: 601 DGSVRKGT 608


>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
           isoform b [Homo sapiens]
          Length = 582

 Score = 1108 bits (2867), Expect = 0.0
 Identities = 538/538 (100%), Positives = 538/538 (100%)

Query: 1   MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT 60
           MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT
Sbjct: 1   MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT 60

Query: 61  RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD 120
           RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD
Sbjct: 61  RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD 120

Query: 121 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD 180
           VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD
Sbjct: 121 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD 180

Query: 181 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI 240
           ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI
Sbjct: 181 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI 240

Query: 241 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI 300
           TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI
Sbjct: 241 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI 300

Query: 301 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL 360
           VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL
Sbjct: 301 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL 360

Query: 361 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF 420
           TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF
Sbjct: 361 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF 420

Query: 421 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS 480
           KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS
Sbjct: 421 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS 480

Query: 481 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRA 538
           LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRA
Sbjct: 481 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRA 538


>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2a [Homo sapiens]
          Length = 613

 Score =  802 bits (2071), Expect = 0.0
 Identities = 426/637 (66%), Positives = 483/637 (75%), Gaps = 63/637 (9%)

Query: 29  MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR--------------- 73
           M K E +E++I+NVGGTRHETYRSTL+TLPGTRLA LA  +  G                
Sbjct: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60

Query: 74  --------PETDG------GGVGSSGSSGG-------GGCEFFFDRHPGVFAYVLNYYRT 112
                   P + G      GG G+  S GG       GG EFFFDRHPGVFAYVLNYYRT
Sbjct: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120

Query: 113 GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAG 172
           GKLHCPADVCGPLFEEEL FWGIDETDVEPCCWMTYRQHRDAEEALDIFE+PD  G    
Sbjct: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG--- 177

Query: 173 PSDEAGDDERELALQRLGPHE--GGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAF 230
              + GDDE +LA +RLG  +  G  G    SG  R  QPRMWALFEDPYSSRAAR +AF
Sbjct: 178 ---DPGDDE-DLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAF 233

Query: 231 ASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVL 290
           ASLFFILVSITTFCLETHEAFNI +N TE   V N TSV  + E+ET+P LTY+EGVCV+
Sbjct: 234 ASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYVEGVCVV 291

Query: 291 WFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVR 350
           WFT EFLVRIV  P+ L+F+KNLLNIIDFVAILPFYLEVGLSGLSSKAA+DVLGFLRVVR
Sbjct: 292 WFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVR 351

Query: 351 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPS 410
           FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER+GA+P+
Sbjct: 352 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPN 411

Query: 411 DPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPV 470
           DP  ++HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGMLVGALCALAGVLTIAMPVPV
Sbjct: 412 DPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPV 471

Query: 471 IVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREE 530
           IVNNFGMYYSLAMAKQKLP+KRKKH+P   Q  SP +CK+E     +ST SDT    ++ 
Sbjct: 472 IVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC-LGKDN 530

Query: 531 GMIERKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACF 590
            ++E  R          +VLS ++  G   PL    +P ER  +RRS+TRD+N++   CF
Sbjct: 531 RLLEHNR----------SVLSGDDSTGSEPPL----SPPERLPIRRSSTRDKNRRGETCF 576

Query: 591 LLSTGDYACA-DGSVRKETCQDALSSNYAQAEVLTLS 626
           LL+TGDY CA DG +RK+ C++ + + Y QAE  +L+
Sbjct: 577 LLTTGDYTCASDGGIRKDNCKEVVITGYTQAEARSLT 613


>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
           isoform A [Homo sapiens]
          Length = 585

 Score =  796 bits (2057), Expect = 0.0
 Identities = 416/593 (70%), Positives = 466/593 (78%), Gaps = 32/593 (5%)

Query: 29  MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSG 88
           M +G+ SE+I+INVGGTRH+TYRSTLRTLPGTRLAWLA+PD     + D           
Sbjct: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRAD------- 53

Query: 89  GGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTY 148
               EFFFDRHPGVFA++LNYYRTGKLHCPADVCGPL+EEEL FWGIDETDVEPCCWMTY
Sbjct: 54  ----EFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTY 109

Query: 149 RQHRDAEEALDIF-------ESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAG 201
           RQHRDAEEALD F        + D    G G S + G+DE E+  +RL   +   G   G
Sbjct: 110 RQHRDAEEALDSFGGAPLDNSADDADADGPGDSGD-GEDELEMT-KRLALSDSPDGRPGG 167

Query: 202 SGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIL 261
               R WQPR+WALFEDPYSSR AR VAFASLFFILVSITTFCLETHE FN   N TEI 
Sbjct: 168 FW--RRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIE 225

Query: 262 RVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVA 321
            V N T V + RE ETE  LTYIEGVCV+WFT EFL+R++ CP+ ++F+KN LNIIDFVA
Sbjct: 226 NVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVA 285

Query: 322 ILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 381
           ILPFYLEVGLSGLSSKAA+DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF
Sbjct: 286 ILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 345

Query: 382 LLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGD 441
           LLLIIFLALGVLIFATMIYYAERIGA+P+DP  ++HT FKNIPIGFWWAVVTMTTLGYGD
Sbjct: 346 LLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGD 405

Query: 442 MYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQ 501
           MYP+TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKK+KKH+PRP Q
Sbjct: 406 MYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQ 465

Query: 502 LESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADSKQNGD-ANAVLSDEEGAGLTQ 560
           L SP YCKS   SP  ST SDT P A+EE ++E  RADSK NG+ A A L++E+   + Q
Sbjct: 466 LGSPNYCKSVVNSPHHSTQSDTCPLAQEE-ILEINRADSKLNGEVAKAALANEDCPHIDQ 524

Query: 561 PLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYAC-ADGSVRKETCQDA 612
            L    TP+E     RS TR+R      CFLLSTG+YAC   G +RK+ C+++
Sbjct: 525 AL----TPDEGLPFTRSGTRER---YGPCFLLSTGEYACPPGGGMRKDLCKES 570


>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2b [Homo sapiens]
          Length = 638

 Score =  787 bits (2032), Expect = 0.0
 Identities = 420/617 (68%), Positives = 470/617 (76%), Gaps = 63/617 (10%)

Query: 29  MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR--------------- 73
           M K E +E++I+NVGGTRHETYRSTL+TLPGTRLA LA  +  G                
Sbjct: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60

Query: 74  --------PETDG------GGVGSSGSSGG-------GGCEFFFDRHPGVFAYVLNYYRT 112
                   P + G      GG G+  S GG       GG EFFFDRHPGVFAYVLNYYRT
Sbjct: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120

Query: 113 GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAG 172
           GKLHCPADVCGPLFEEEL FWGIDETDVEPCCWMTYRQHRDAEEALDIFE+PD  G    
Sbjct: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG--- 177

Query: 173 PSDEAGDDERELALQRLGPHE--GGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAF 230
              + GDDE +LA +RLG  +  G  G    SG  R  QPRMWALFEDPYSSRAAR +AF
Sbjct: 178 ---DPGDDE-DLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAF 233

Query: 231 ASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVL 290
           ASLFFILVSITTFCLETHEAFNI +N TE   V N TSV  + E+ET+P LTY+EGVCV+
Sbjct: 234 ASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYVEGVCVV 291

Query: 291 WFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVR 350
           WFT EFLVRIV  P+ L+F+KNLLNIIDFVAILPFYLEVGLSGLSSKAA+DVLGFLRVVR
Sbjct: 292 WFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVR 351

Query: 351 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPS 410
           FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER+GA+P+
Sbjct: 352 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPN 411

Query: 411 DPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPV 470
           DP  ++HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGMLVGALCALAGVLTIAMPVPV
Sbjct: 412 DPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPV 471

Query: 471 IVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREE 530
           IVNNFGMYYSLAMAKQKLP+KRKKH+P   Q  SP +CK+E     +ST SDT    ++ 
Sbjct: 472 IVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC-LGKDN 530

Query: 531 GMIERKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACF 590
            ++E  R          +VLS ++  G   PL    +P ER  +RRS+TRD+N++   CF
Sbjct: 531 RLLEHNR----------SVLSGDDSTGSEPPL----SPPERLPIRRSSTRDKNRRGETCF 576

Query: 591 LLSTGDYACA-DGSVRK 606
           LL+TGDY CA DG +RK
Sbjct: 577 LLTTGDYTCASDGGIRK 593


>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
           isoform B [Homo sapiens]
          Length = 511

 Score =  751 bits (1939), Expect = 0.0
 Identities = 384/520 (73%), Positives = 421/520 (80%), Gaps = 23/520 (4%)

Query: 29  MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSG 88
           M +G+ SE+I+INVGGTRH+TYRSTLRTLPGTRLAWLA+PD     + D           
Sbjct: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRAD------- 53

Query: 89  GGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTY 148
               EFFFDRHPGVFA++LNYYRTGKLHCPADVCGPL+EEEL FWGIDETDVEPCCWMTY
Sbjct: 54  ----EFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTY 109

Query: 149 RQHRDAEEALDIF-------ESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAG 201
           RQHRDAEEALD F        + D    G G S + G+DE E+  +RL   +   G   G
Sbjct: 110 RQHRDAEEALDSFGGAPLDNSADDADADGPGDSGD-GEDELEMT-KRLALSDSPDGRPGG 167

Query: 202 SGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIL 261
               R WQPR+WALFEDPYSSR AR VAFASLFFILVSITTFCLETHE FN   N TEI 
Sbjct: 168 FW--RRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIE 225

Query: 262 RVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVA 321
            V N T V + RE ETE  LTYIEGVCV+WFT EFL+R++ CP+ ++F+KN LNIIDFVA
Sbjct: 226 NVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVA 285

Query: 322 ILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 381
           ILPFYLEVGLSGLSSKAA+DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF
Sbjct: 286 ILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 345

Query: 382 LLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGD 441
           LLLIIFLALGVLIFATMIYYAERIGA+P+DP  ++HT FKNIPIGFWWAVVTMTTLGYGD
Sbjct: 346 LLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGD 405

Query: 442 MYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQ 501
           MYP+TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKK+KKH+PRP Q
Sbjct: 406 MYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQ 465

Query: 502 LESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADSK 541
           L SP YCKS   SP  ST SDT P A+EE ++E  RA  K
Sbjct: 466 LGSPNYCKSVVNSPHHSTQSDTCPLAQEE-ILEINRAGRK 504


>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2c [Homo sapiens]
          Length = 558

 Score =  742 bits (1915), Expect = 0.0
 Identities = 391/550 (71%), Positives = 432/550 (78%), Gaps = 48/550 (8%)

Query: 29  MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR--------------- 73
           M K E +E++I+NVGGTRHETYRSTL+TLPGTRLA LA  +  G                
Sbjct: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60

Query: 74  --------PETDG------GGVGSSGSSGG-------GGCEFFFDRHPGVFAYVLNYYRT 112
                   P + G      GG G+  S GG       GG EFFFDRHPGVFAYVLNYYRT
Sbjct: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120

Query: 113 GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAG 172
           GKLHCPADVCGPLFEEEL FWGIDETDVEPCCWMTYRQHRDAEEALDIFE+PD  G    
Sbjct: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG--- 177

Query: 173 PSDEAGDDERELALQRLGPHE--GGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAF 230
              + GDDE +LA +RLG  +  G  G    SG  R  QPRMWALFEDPYSSRAAR +AF
Sbjct: 178 ---DPGDDE-DLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAF 233

Query: 231 ASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVL 290
           ASLFFILVSITTFCLETHEAFNI +N TE   V N TSV  + E+ET+P LTY+EGVCV+
Sbjct: 234 ASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYVEGVCVV 291

Query: 291 WFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVR 350
           WFT EFLVRIV  P+ L+F+KNLLNIIDFVAILPFYLEVGLSGLSSKAA+DVLGFLRVVR
Sbjct: 292 WFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVR 351

Query: 351 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPS 410
           FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER+GA+P+
Sbjct: 352 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPN 411

Query: 411 DPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPV 470
           DP  ++HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGMLVGALCALAGVLTIAMPVPV
Sbjct: 412 DPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPV 471

Query: 471 IVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREE 530
           IVNNFGMYYSLAMAKQKLP+KRKKH+P   Q  SP +CK+E     +ST SDT    ++ 
Sbjct: 472 IVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC-LGKDN 530

Query: 531 GMIERKRADS 540
            ++E  R+D+
Sbjct: 531 RLLEHNRSDN 540


>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
           [Homo sapiens]
          Length = 757

 Score =  715 bits (1845), Expect = 0.0
 Identities = 388/597 (64%), Positives = 424/597 (71%), Gaps = 97/597 (16%)

Query: 1   MISSVCVSSYRGRKSGNK--------------PPSKTCLKEEMAK--------------- 31
           M+SSVCVSS+RGR+  +K              PP     +++ A+               
Sbjct: 1   MLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRG 60

Query: 32  -----------------------GEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADP 68
                                  G  S KI+INVGG RHETYRSTLRTLPGTRLA L +P
Sbjct: 61  PGDRRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEP 120

Query: 69  DGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE 128
           +   R + D G             EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE
Sbjct: 121 EAAARFDYDPGAD-----------EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE 169

Query: 129 ELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPD---------------GG-----G 168
           EL FWGIDETDVE CCWMTYRQHRDAEEALD FE+PD               GG     G
Sbjct: 170 ELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAG 229

Query: 169 SGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGG---CRGWQPRMWALFEDPYSSRAA 225
           +G G  D AG + + L  Q  G   GG   GAG  G    R WQPR+WALFEDPYSSRAA
Sbjct: 230 AGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAA 289

Query: 226 RVVAFASLFFILVSITTFCLETHEAFN--IDRNVTEILRVG-----NITSVHFRREVETE 278
           R VAFASLFFIL+SITTFCLETHE F    ++ VT+   +      NIT+V    EVETE
Sbjct: 290 RYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNV----EVETE 345

Query: 279 PILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKA 338
           P LTY+EGVCV+WFT EFL+RI  CPD ++F+K+ LNIID VAILPFYLEVGLSGLSSKA
Sbjct: 346 PFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKA 405

Query: 339 ARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM 398
           A+DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM
Sbjct: 406 AKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM 465

Query: 399 IYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCAL 458
           IYYAERIGA P D  G++HT FKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCAL
Sbjct: 466 IYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCAL 525

Query: 459 AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSP 515
           AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKK+ KH+PRP Q  SP YCK +   P
Sbjct: 526 AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPP 582



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 35/85 (41%), Positives = 48/85 (56%), Gaps = 8/85 (9%)

Query: 526 PAREEGMIERKRADSKQNGD-ANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNK 584
           P  +E +IE  RAD + NGD A A L+ E+   + QP  S   PE++  +    +R R  
Sbjct: 647 PLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQPAMS---PEDKSPITPG-SRGRYS 702

Query: 585 KAAACFLLSTGDYA-CADGSVRKET 608
           +  ACFLL+  DYA   DGS+RK T
Sbjct: 703 RDRACFLLT--DYAPSPDGSIRKAT 725


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score =  299 bits (765), Expect = 6e-81
 Identities = 177/490 (36%), Positives = 261/490 (53%), Gaps = 63/490 (12%)

Query: 7   VSSYRGRKSGNKPPSKTCLKEEMAKGEA-SEKIIINVGGTRHETYRSTLRTLPGTRLAWL 65
           ++ +  R + + PP       E+ + +A S ++ +NVGG  HE    TL  LP TRL  L
Sbjct: 5   MTKHGSRSTSSLPPEPM----EIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL 60

Query: 66  ADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPL 125
            D +      T    +           E+FFDRHPG F  +LN+YRTG+LH   ++C   
Sbjct: 61  RDCN------THDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALS 114

Query: 126 FEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELA 185
           F +EL +WGIDE  +E CC   Y Q +                       E  ++E +  
Sbjct: 115 FSQELDYWGIDEIYLESCCQARYHQKK-----------------------EQMNEELKRE 151

Query: 186 LQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCL 245
            + L   EG       +  C   + ++W L E P SS AA+++A  S+ FI++S     L
Sbjct: 152 AETLREREG---EEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSL 208

Query: 246 ETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPD 305
            T               +  + S+    +    P L ++E VC+ WFT+E+L+R +  P 
Sbjct: 209 NT---------------LPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPK 253

Query: 306 TLDFVKNLLNIIDFVAILPFYLEVGL--SGLSSKAARDVLGFLRVVRFVRILRIFKLTRH 363
              F K  LN ID +AILP+Y+ + L  S  S    ++V   +++ R +RILRI KL RH
Sbjct: 254 KWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARH 313

Query: 364 FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNI 423
             GL+ LG TLR S NE  LLI+FLA+G++IF++++++AE+           D T FK+I
Sbjct: 314 STGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDDTKFKSI 364

Query: 424 PIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 483
           P  FWWA +TMTT+GYGD+YPKT  G +VG LC +AGVL IA+P+P+IVNNF  +Y    
Sbjct: 365 PASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQK 424

Query: 484 AKQKLPKKRK 493
            ++K  K+R+
Sbjct: 425 RQEKAIKRRE 434


>gi|27436974 potassium voltage-gated channel, Shab-related
           subfamily, member 2 [Homo sapiens]
          Length = 911

 Score =  297 bits (761), Expect = 2e-80
 Identities = 177/475 (37%), Positives = 253/475 (53%), Gaps = 68/475 (14%)

Query: 21  SKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGG 80
           SKTC          S ++ INVGG  HE    TL  LP TRL  L D +      T    
Sbjct: 30  SKTC----------SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCN------THESL 73

Query: 81  VGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDV 140
           +           E+FFDRHPG F  +LN+YRTGKLH   ++C   F +EL +WGIDE  +
Sbjct: 74  LEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYL 133

Query: 141 EPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGA 200
           E CC   Y Q ++                     +E    E E   +R        G   
Sbjct: 134 ESCCQARYHQKKEQ-------------------MNEELRREAETMRER-------EGEEF 167

Query: 201 GSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEI 260
            +  C   + ++W L E P SS AA+++A  S+ FI++S     L T         + E+
Sbjct: 168 DNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNT---------LPEL 218

Query: 261 LRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFV 320
                   ++  R+      L ++E VC+ WFT+E+L+R +  P+   F K  LN+ID +
Sbjct: 219 QETDEFGQLNDNRQ------LAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLL 272

Query: 321 AILPFYLEVGL--SGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRAST 378
           AILP+Y+ + L  S  S    ++V   +++ R +RILRI KL RH  GL+ LG TLR S 
Sbjct: 273 AILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSY 332

Query: 379 NEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLG 438
           NE  LLI+FLA+G++IF++++++AE+           D T F +IP  FWWA +TMTT+G
Sbjct: 333 NELGLLILFLAMGIMIFSSLVFFAEK---------DEDATKFTSIPASFWWATITMTTVG 383

Query: 439 YGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRK 493
           YGD+YPKT  G +VG LC +AGVL IA+P+P+IVNNF  +Y     ++K  K+R+
Sbjct: 384 YGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 438


>gi|119395748 potassium voltage-gated channel subfamily A member 1
           [Homo sapiens]
          Length = 495

 Score =  271 bits (692), Expect = 2e-72
 Identities = 167/453 (36%), Positives = 240/453 (52%), Gaps = 77/453 (16%)

Query: 33  EASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGC 92
           E  E+++IN+ G R ET   TL   P T L         G P+          +      
Sbjct: 34  ECCERVVINISGLRFETQLKTLAQFPNTLL---------GNPKKRMRYFDPLRN------ 78

Query: 93  EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQH 151
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 79  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYEL---------------- 122

Query: 152 RDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPR 211
              EEA++ F   +G            ++ER L  +                    +Q +
Sbjct: 123 --GEEAMEKFREDEGF---------IKEEERPLPEKE-------------------YQRQ 152

Query: 212 MWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHF 271
           +W LFE P SS  ARV+A  S+  IL+SI  FCLET      D++ T  +   + T+V +
Sbjct: 153 VWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIY 212

Query: 272 RREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGL 331
              + T+P    +E +C++WF+ E +VR   CP   DF KN++N ID VAI+P+++ +G 
Sbjct: 213 NSNIFTDPFFI-VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGT 271

Query: 332 S-----GLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 386
                 G         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI 
Sbjct: 272 EIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIF 331

Query: 387 FLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKT 446
           FL +GV++F++ +Y+AE   A          + F +IP  FWWAVV+MTT+GYGDMYP T
Sbjct: 332 FLFIGVILFSSAVYFAEAEEAE---------SHFSSIPDAFWWAVVSMTTVGYGDMYPVT 382

Query: 447 WSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479
             G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 383 IGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 415


>gi|27436981 potassium voltage-gated channel, Shal-related
           subfamily, member 1 [Homo sapiens]
          Length = 647

 Score =  264 bits (675), Expect = 2e-70
 Identities = 166/467 (35%), Positives = 243/467 (52%), Gaps = 71/467 (15%)

Query: 36  EKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFF 95
           E +++NV G R ET+++TL   P T L         G  E +      SG       E+F
Sbjct: 40  EVLVVNVSGRRFETWKNTLDRYPDTLL---------GSSEKEFFYDADSG-------EYF 83

Query: 96  FDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAE 155
           FDR P +F +VLN+YRTG+LHCP   C   F+EEL F+G+    V  CC   YR  R  E
Sbjct: 84  FDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRD-RKKE 142

Query: 156 EALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWAL 215
            A  + E  +   +G GP+  AG   R+                           R+W  
Sbjct: 143 NAERLAEDEEAEQAGDGPALPAGSSLRQ---------------------------RLWRA 175

Query: 216 FEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREV 275
           FE+P++S AA V  + + FFI VS+    +ET       R  +     G      F    
Sbjct: 176 FENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAF---- 231

Query: 276 ETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLS 335
                   ++  CVL FT E+L+R+   P    F+++++++ID VAILP+Y+     GL 
Sbjct: 232 ------FCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLL 280

Query: 336 SKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIF 395
                DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IF
Sbjct: 281 VPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIF 340

Query: 396 ATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGAL 455
           AT+++YAE+         G + T+F +IP  FW+ +VTMTTLGYGDM P T +G + G++
Sbjct: 341 ATVMFYAEK---------GTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSI 391

Query: 456 CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQL 502
           C+L+GVL IA+PVPVIV+NF   Y      Q+  K+R +   R A++
Sbjct: 392 CSLSGVLVIALPVPVIVSNFSRIYH---QNQRADKRRAQQKVRLARI 435


>gi|25952092 potassium voltage-gated channel, shaker-related
           subfamily, member 7 [Homo sapiens]
          Length = 456

 Score =  261 bits (668), Expect = 1e-69
 Identities = 181/467 (38%), Positives = 240/467 (51%), Gaps = 101/467 (21%)

Query: 36  EKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFF 95
           E++++NV G R ET   TL   P T L    DP   GR   D               E+F
Sbjct: 13  ERLVLNVAGLRFETRARTLGRFPDTLLG---DPARRGRFYDDARR------------EYF 57

Query: 96  FDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDA 154
           FDRH   F  VL YY++G +L  PA V   +F EE+ F+G+                   
Sbjct: 58  FDRHRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGL------------------- 98

Query: 155 EEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWA 214
                          GA             AL RL   EG           R +  ++W 
Sbjct: 99  ---------------GAA------------ALARLREDEGCPVPPERPLPRRAFARQLWL 131

Query: 215 LFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRV----------- 263
           LFE P SS+AARV+A  S+  ILVSI  FCLET   F  DR+ T +              
Sbjct: 132 LFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDGTGLAAAAAAGPFPAPLN 191

Query: 264 ------GNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNII 317
                 GN   + F      +P    +E +C+ WF+ E LVR++ CP    F KN++N+I
Sbjct: 192 GSSQMPGNPPRLPFN-----DPFFV-VETLCICWFSFELLVRLLVCPSKAIFFKNVMNLI 245

Query: 318 DFVAILPFYLEVGLS-----GLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGH 372
           DFVAILP+++ +G       G+  +A    L  LRV+R VR+ RIFKL+RH  GL++LG 
Sbjct: 246 DFVAILPYFVALGTELARQRGVGQQAMS--LAILRVIRLVRVFRIFKLSRHSKGLQILGQ 303

Query: 373 TLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVV 432
           TLRAS  E  LLI FL +GV++F++ +Y+AE         R + H  F +IP  FWWAVV
Sbjct: 304 TLRASMRELGLLIFFLFIGVVLFSSAVYFAEV-------DRVDSH--FTSIPESFWWAVV 354

Query: 433 TMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479
           TMTT+GYGDM P T  G +VG+LCA+AGVLTI++PVPVIV+NF  +Y
Sbjct: 355 TMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFY 401


>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
           member 2 [Homo sapiens]
          Length = 630

 Score =  261 bits (667), Expect = 1e-69
 Identities = 182/590 (30%), Positives = 285/590 (48%), Gaps = 113/590 (19%)

Query: 38  IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFD 97
           I++NV GTR +T++ TL   P T L   ++ D    PET                ++FFD
Sbjct: 43  IVLNVSGTRFQTWQDTLERYPDTLLG-SSERDFFYHPETQ---------------QYFFD 86

Query: 98  RHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYR-QHRDAEE 156
           R P +F ++LN+YRTGKLH P   C   ++EEL F+G+    +  CC+  Y+ + R+  E
Sbjct: 87  RDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAE 146

Query: 157 ALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALF 216
            L      D  G  A P+  A                               + R+W  F
Sbjct: 147 RLQDDADTDTAGESALPTMTA-------------------------------RQRVWRAF 175

Query: 217 EDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVE 276
           E+P++S  A V  + + FFI VS+    +ET    +   ++ E L  G   +V F     
Sbjct: 176 ENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKE-LPCGERYAVAF----- 229

Query: 277 TEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSS 336
                  ++  CV+ FT+E+L+R+   P    FV+++++IID VAILP+Y+     GL  
Sbjct: 230 -----FCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI-----GLVM 279

Query: 337 KAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 396
               DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFA
Sbjct: 280 TDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339

Query: 397 TMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALC 456
           T+++YAE+         G+  + F +IP  FW+ +VTMTTLGYGDM PKT +G + G++C
Sbjct: 340 TVMFYAEK---------GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 390

Query: 457 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPR 516
           +L+GVL IA+PVPVIV+NF   Y      Q+  K+R                        
Sbjct: 391 SLSGVLVIALPVPVIVSNFSRIYH---QNQRADKRR------------------------ 423

Query: 517 DSTCSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRR 576
                     A+++  + R RA   ++G ANA +  +    L+  L SS   +   +   
Sbjct: 424 ----------AQKKARLARIRA--AKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSG 471

Query: 577 STTRDRNKKAAACFLLSTGDYACADGSVRKETCQDALSSNYAQAEVLTLS 626
           S+   ++     C L  T ++   D  V +E+C +  + N   +   +LS
Sbjct: 472 SSFETQHHHLLHC-LEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLS 520


>gi|4504817 potassium voltage-gated channel, shaker-related
           subfamily, member 4 [Homo sapiens]
          Length = 653

 Score =  260 bits (665), Expect = 2e-69
 Identities = 176/465 (37%), Positives = 243/465 (52%), Gaps = 88/465 (18%)

Query: 33  EASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGC 92
           +  E+++INV G R ET   TL   P T L         G PE          +      
Sbjct: 173 DCCERVVINVSGLRFETQMKTLAQFPETLL---------GDPEKRTQYFDPLRN------ 217

Query: 93  EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQH 151
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 218 EYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQL---------------- 261

Query: 152 RDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPR 211
              EEAL  F   +G             +E + AL                     ++ +
Sbjct: 262 --GEEALLKFREDEGFVR----------EEEDRALPE-----------------NEFKKQ 292

Query: 212 MWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVG------N 265
           +W LFE P SS  AR +A  S+  IL+SI  FCLET   F  DR++   L  G      N
Sbjct: 293 IWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLN 352

Query: 266 ITSV-HFRREVET---EPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVA 321
            TS  H      T   +P    +E VC++WF+ EF+VR   CP    F KN++NIID V+
Sbjct: 353 DTSAPHLENSGHTIFNDPFFI-VETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVS 411

Query: 322 ILPFYLEVGLS-----GLSSKAARDVLGF--LRVVRFVRILRIFKLTRHFVGLRVLGHTL 374
           ILP+++ +G       G  +   +  + F  LR++R VR+ RIFKL+RH  GL++LGHTL
Sbjct: 412 ILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTL 471

Query: 375 RASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTM 434
           RAS  E  LLI FL +GV++F++ +Y+AE       +P     T F++IP  FWWAVVTM
Sbjct: 472 RASMRELGLLIFFLFIGVILFSSAVYFAEA-----DEPT----THFQSIPDAFWWAVVTM 522

Query: 435 TTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479
           TT+GYGDM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 523 TTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 567


>gi|5031819 potassium voltage-gated channel, shaker-related
           subfamily, member 10 [Homo sapiens]
          Length = 511

 Score =  260 bits (665), Expect = 2e-69
 Identities = 170/477 (35%), Positives = 247/477 (51%), Gaps = 82/477 (17%)

Query: 27  EEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGS 86
           E +   E ++++IIN+ G R ET   TL   P T L         G  E       S  +
Sbjct: 77  EPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLL---------GDREKRMQFFDSMRN 127

Query: 87  SGGGGCEFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCW 145
                 E+FFDR+   F  +L YY++G K+  PA+V   +F +E++F+ +          
Sbjct: 128 ------EYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYEL---------- 171

Query: 146 MTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGC 205
                     EA+D F             DE    + E  L     H             
Sbjct: 172 --------GSEAMDQFRE-----------DEGFIKDPETLLPTNDIHR------------ 200

Query: 206 RGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVG- 264
                + W LFE P SS AAR VA  S+  +++SIT FCLET   F  DR +  +     
Sbjct: 201 -----QFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNL 255

Query: 265 NITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILP 324
           N++     + + T+P    +E  C++WFT E ++R V CP   DF +N++NIID ++I+P
Sbjct: 256 NMSKTVLSQTMFTDPFFM-VESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIP 314

Query: 325 FYL----EVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNE 380
           ++     E+      S      L  LR++R VR+ RIFKL+RH  GL++LG TL+AS  E
Sbjct: 315 YFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRE 374

Query: 381 FLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYG 440
             LLI FL +GV++F++ +Y+AE       +P  +    F +IP GFWWAVVTMTT+GYG
Sbjct: 375 LGLLIFFLFIGVILFSSAVYFAE-----VDEPESH----FSSIPDGFWWAVVTMTTVGYG 425

Query: 441 DMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVP 497
           DM P T  G +VG LCA+AGVLTIA+PVPVIV+NF  +Y      ++   + K+++P
Sbjct: 426 DMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFY-----HRETENEEKQNIP 477


>gi|4826782 potassium voltage-gated channel, shaker-related
           subfamily, member 2 [Homo sapiens]
          Length = 499

 Score =  258 bits (659), Expect = 1e-68
 Identities = 169/467 (36%), Positives = 245/467 (52%), Gaps = 93/467 (19%)

Query: 30  AKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR---PETDGGGVGSSGS 86
           A  E  E+++IN+ G R ET   TL   P T L    DP    R   P  +         
Sbjct: 27  ADHECCERVVINISGLRFETQLKTLAQFPETLLG---DPKKRMRYFDPLRN--------- 74

Query: 87  SGGGGCEFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCW 145
                 E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +          
Sbjct: 75  ------EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYEL---------- 118

Query: 146 MTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGC 205
                    EEA+++F   +G            ++ER L                     
Sbjct: 119 --------GEEAMEMFREDEG---------YIKEEERPLPENE----------------- 144

Query: 206 RGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGN 265
             +Q ++W LFE P SS  AR++A  S+  IL+SI +FCLET   F   R+  E +    
Sbjct: 145 --FQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIF---RDENEDMHGSG 199

Query: 266 IT-------SVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIID 318
           +T       ++ +++          +E +C++WF+ EFLVR   CP    F  N++NIID
Sbjct: 200 VTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID 259

Query: 319 FVAILPFYLEVG--LSGLSSKAARDV----LGFLRVVRFVRILRIFKLTRHFVGLRVLGH 372
            VAI+P+++ +G  L+     A +      L  LRV+R VR+ RIFKL+RH  GL++LG 
Sbjct: 260 IVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQ 319

Query: 373 TLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVV 432
           TL+AS  E  LLI FL +GV++F++ +Y+AE      +D R    + F +IP  FWWAVV
Sbjct: 320 TLKASMRELGLLIFFLFIGVILFSSAVYFAE------ADER---ESQFPSIPDAFWWAVV 370

Query: 433 TMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479
           +MTT+GYGDM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 371 SMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417


>gi|88758565 potassium voltage-gated channel, shaker-related
           subfamily, member 3 [Homo sapiens]
          Length = 575

 Score =  255 bits (651), Expect = 1e-67
 Identities = 174/476 (36%), Positives = 240/476 (50%), Gaps = 93/476 (19%)

Query: 19  PPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR---PE 75
           PPS     E+   GE   +++IN+ G R ET   TL   P T L    DP    R   P 
Sbjct: 90  PPSLPAAGEQDCCGE---RVVINISGLRFETQLKTLCQFPETLLG---DPKRRMRYFDPL 143

Query: 76  TDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWG 134
            +               E+FFDR+   F  +L YY++G ++  P +V   +F EE+ F+ 
Sbjct: 144 RN---------------EYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQ 188

Query: 135 IDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEG 194
           +                   EEA++ F             DE    E E  L R      
Sbjct: 189 L------------------GEEAMEKFRE-----------DEGFLREEERPLPR------ 213

Query: 195 GAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNID 254
                      R +Q ++W LFE P SS  AR +A  S+  IL+SI  FCLET   F  +
Sbjct: 214 -----------RDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDE 262

Query: 255 RNVT------EILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLD 308
           ++             GN TS               +E +C++WF+ E LVR   CP    
Sbjct: 263 KDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKAT 322

Query: 309 FVKNLLNIIDFVAILPFYLEVGLS-----GLSSKAARDVLGFLRVVRFVRILRIFKLTRH 363
           F +N++N+ID VAI+P+++ +G       G   +A    L  LRV+R VR+ RIFKL+RH
Sbjct: 323 FSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMS--LAILRVIRLVRVFRIFKLSRH 380

Query: 364 FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNI 423
             GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE       DP       F +I
Sbjct: 381 SKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEA-----DDPTSG----FSSI 431

Query: 424 PIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479
           P  FWWAVVTMTT+GYGDM+P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 432 PDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 487


>gi|27436986 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 2 [Homo sapiens]
          Length = 636

 Score =  254 bits (650), Expect = 1e-67
 Identities = 178/593 (30%), Positives = 276/593 (46%), Gaps = 116/593 (19%)

Query: 36  EKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFF 95
           E I++NV G R +T+R+TL   P T L                G             E+F
Sbjct: 40  ELIVLNVSGRRFQTWRTTLERYPDTLL----------------GSTEKEFFFNEDTKEYF 83

Query: 96  FDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTY--RQHRD 153
           FDR P VF  VLN+YRTGKLH P   C   +++EL F+GI    +  CC+  Y  R+  +
Sbjct: 84  FDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKREN 143

Query: 154 AEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMW 213
           AE  +D              +D   + E   +L                     ++  MW
Sbjct: 144 AERLMD-------------DNDSENNQESMPSLS--------------------FRQTMW 170

Query: 214 ALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRR 273
             FE+P++S  A V  + + FFI VS+ T  +ET     +  +  + L  G   SV F  
Sbjct: 171 RAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGS--KELPCGERYSVAF-- 226

Query: 274 EVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSG 333
                     ++  CV+ FT+E+L+R+   P    F++++++IID VAI+P+Y+     G
Sbjct: 227 --------FCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYI-----G 273

Query: 334 LSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVL 393
           L      DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++
Sbjct: 274 LVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAII 333

Query: 394 IFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVG 453
           IFAT+++YAE+         G+  + F +IP  FW+ +VTMTTLGYGDM PKT +G + G
Sbjct: 334 IFATVMFYAEK---------GSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFG 384

Query: 454 ALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEET 513
           ++C+L+GVL IA+PVPVIV+NF   Y      Q+  K+R +   R A++           
Sbjct: 385 SICSLSGVLVIALPVPVIVSNFSRIYH---QNQRADKRRAQKKARLARIR---------- 431

Query: 514 SPRDSTCSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRA 573
                                       + G +NA L  +    L + L  + TPEE   
Sbjct: 432 --------------------------VAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHM 465

Query: 574 LRRSTTRDRNKKAAACFLLSTGDYACADGSVRKETCQDALSSNYAQAEVLTLS 626
            + ++  +         L  T ++   D  + ++ C ++   NY      +LS
Sbjct: 466 GKTTSLIESQHHHLLHCLEKTTNHEFIDEQMFEQNCMESSMQNYPSTRSPSLS 518


>gi|4504821 potassium voltage-gated channel, shaker-related
           subfamily, member 6 [Homo sapiens]
          Length = 529

 Score =  254 bits (649), Expect = 2e-67
 Identities = 173/494 (35%), Positives = 245/494 (49%), Gaps = 115/494 (23%)

Query: 34  ASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCE 93
           +SE+++IN+ G R ET   TL   P T L    DP   GR       + +         E
Sbjct: 39  SSERLVINISGLRFETQLRTLSLFPDTLLG---DP---GRRVRFFDPLRN---------E 83

Query: 94  FFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHR 152
           +FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                 
Sbjct: 84  YFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQL----------------- 126

Query: 153 DAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRM 212
             +EAL  F   +G         E G+DE+ L  Q                    +Q ++
Sbjct: 127 -GDEALAAFREDEGC------LPEGGEDEKPLPSQP-------------------FQRQV 160

Query: 213 WALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDR---NVTEILRVGNITSV 269
           W LFE P SS  AR +A  S+  IL+SI  FCLET   F +D    N   + RV  ++  
Sbjct: 161 WLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRG 220

Query: 270 HFRREVETEPILTY-------------------------------IEGVCVLWFTLEFLV 298
               E + +   T+                               +E +C++WFT E LV
Sbjct: 221 SQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLV 280

Query: 299 RIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLG-------------F 345
           R   CP    F +N++NIID VAI P+++ +G   +  +  +   G              
Sbjct: 281 RFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAI 340

Query: 346 LRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERI 405
           LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE  
Sbjct: 341 LRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEA- 399

Query: 406 GARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIA 465
                    +D + F +IP  FWWAVVTMTT+GYGDMYP T  G +VG+LCA+AGVLTIA
Sbjct: 400 --------DDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIA 451

Query: 466 MPVPVIVNNFGMYY 479
           +PVPVIV+NF  +Y
Sbjct: 452 LPVPVIVSNFNYFY 465


>gi|27436984 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 1 [Homo sapiens]
          Length = 655

 Score =  250 bits (639), Expect = 2e-66
 Identities = 160/469 (34%), Positives = 241/469 (51%), Gaps = 80/469 (17%)

Query: 36  EKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFF 95
           E I++NV G R +T+R+TL   P T L                G             E+F
Sbjct: 40  ELIVLNVSGRRFQTWRTTLERYPDTLL----------------GSTEKEFFFNEDTKEYF 83

Query: 96  FDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTY--RQHRD 153
           FDR P VF  VLN+YRTGKLH P   C   +++EL F+GI    +  CC+  Y  R+  +
Sbjct: 84  FDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKREN 143

Query: 154 AEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMW 213
           AE  +D              +D   + E   +L                     ++  MW
Sbjct: 144 AERLMD-------------DNDSENNQESMPSLS--------------------FRQTMW 170

Query: 214 ALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRR 273
             FE+P++S  A V  + + FFI VS+ T  +ET     +  +  + L  G   SV F  
Sbjct: 171 RAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGS--KELPCGERYSVAF-- 226

Query: 274 EVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSG 333
                     ++  CV+ FT+E+L+R+   P    F++++++IID VAI+P+Y+     G
Sbjct: 227 --------FCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYI-----G 273

Query: 334 LSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVL 393
           L      DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++
Sbjct: 274 LVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAII 333

Query: 394 IFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVG 453
           IFAT+++YAE+         G+  + F +IP  FW+ +VTMTTLGYGDM PKT +G + G
Sbjct: 334 IFATVMFYAEK---------GSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFG 384

Query: 454 ALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQL 502
           ++C+L+GVL IA+PVPVIV+NF   Y      Q+  K+R +   R A++
Sbjct: 385 SICSLSGVLVIALPVPVIVSNFSRIYH---QNQRADKRRAQKKARLARI 430


>gi|25952087 potassium voltage-gated channel, shaker-related
           subfamily, member 5 [Homo sapiens]
          Length = 613

 Score =  246 bits (627), Expect = 6e-65
 Identities = 177/490 (36%), Positives = 242/490 (49%), Gaps = 111/490 (22%)

Query: 27  EEMAKGEAS---EKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGS 83
           E+ A G AS   +++ IN+ G R ET   TL   P T L   A       P  +      
Sbjct: 108 EDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRN------ 161

Query: 84  SGSSGGGGCEFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEP 142
                    E+FFDR+   F  +L YY++G +L  P +V   +F +E+ F+ +       
Sbjct: 162 ---------EYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQL------- 205

Query: 143 CCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGS 202
                       +EA++ F             DE    E E  L R              
Sbjct: 206 -----------GDEAMERFRE-----------DEGFIKEEEKPLPR-------------- 229

Query: 203 GGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILR 262
                +Q ++W +FE P SS +AR +A  S+  IL+SI TFCLET   F  +R   E+LR
Sbjct: 230 ---NEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDER---ELLR 283

Query: 263 V-------------GNITSVHFRREVET-EPILT--------YIEGVCVLWFTLEFLVRI 300
                          N + V       T  P+L          +E  CV+WFT E LVR 
Sbjct: 284 HPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRF 343

Query: 301 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLS-----------GLSSKAARDVLGFLRVV 349
             CP    F +N++NIID VAI P+++ +G             G + + A   L  LRV+
Sbjct: 344 FACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMS-LAILRVI 402

Query: 350 RFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARP 409
           R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE      
Sbjct: 403 RLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEA----- 457

Query: 410 SDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVP 469
                N  T F +IP  FWWAVVTMTT+GYGDM P T  G +VG+LCA+AGVLTIA+PVP
Sbjct: 458 ----DNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVP 513

Query: 470 VIVNNFGMYY 479
           VIV+NF  +Y
Sbjct: 514 VIVSNFNYFY 523


>gi|25952108 potassium voltage-gated channel delayed-rectifier
           protein S3 [Homo sapiens]
          Length = 491

 Score =  241 bits (616), Expect = 1e-63
 Identities = 147/451 (32%), Positives = 233/451 (51%), Gaps = 51/451 (11%)

Query: 32  GEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGG 91
           G+  E + +NVGG +    +STL   P TRL  L          ++   +          
Sbjct: 11  GQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTC------HSEEAILELCDDYSVAD 64

Query: 92  CEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQH 151
            E++FDR+P +F YVLN+Y TGKLH   ++C   F +E+ +WGI+E  ++ CC   Y++ 
Sbjct: 65  KEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQER 124

Query: 152 RDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPR 211
           ++     D ++      S     +E+   E+EL  ++      G             + +
Sbjct: 125 KEENHEKD-WDQKSHDVSTDSSFEESSLFEKEL--EKFDTLRFGQ-----------LRKK 170

Query: 212 MWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHF 271
           +W   E+P    +A+++A +SL  +L SI   C+ +   F  +    +            
Sbjct: 171 IWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVD------------ 218

Query: 272 RREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFY--LEV 329
                 +P+L  +E  C+ WFT E  VR+   P    F KN LNIIDFV+I+PFY  L V
Sbjct: 219 ------DPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAV 272

Query: 330 GLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLA 389
                 S+   ++   ++++R +RI RI KL RH VGLR LG TLR S +E  LL++FL+
Sbjct: 273 DTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLS 332

Query: 390 LGVLIFATMIYYAERIGARPSDPRGNDHTD-FKNIPIGFWWAVVTMTTLGYGDMYPKTWS 448
           +G+ IF+ +IY  E+          +DHT    +IPI +WWA ++MTT+GYGD +P T +
Sbjct: 333 VGISIFSVLIYSVEK----------DDHTSSLTSIPICWWWATISMTTVGYGDTHPVTLA 382

Query: 449 GMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479
           G L+ + C + G+L +A+P+ +I N F  YY
Sbjct: 383 GKLIASTCIICGILVVALPITIIFNKFSKYY 413


>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
          Length = 500

 Score =  240 bits (612), Expect = 3e-63
 Identities = 154/475 (32%), Positives = 235/475 (49%), Gaps = 66/475 (13%)

Query: 27  EEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSS-- 84
           E +A G+      +NVGG+R    +  L   P TRL  LA      R       V S   
Sbjct: 33  EPLALGDC---FTVNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLE 89

Query: 85  --GSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEP 142
               +     E+FFDR    F YVL+YYRTG+LH    +C   F +E+ +WGIDE  ++ 
Sbjct: 90  LCDDANPVDNEYFFDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDS 149

Query: 143 CCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGS 202
           CC   Y + ++  E LD  +  +         D+    E E                   
Sbjct: 150 CCRDRYFRRKELSETLDFKKDTE---------DQESQHESE--------------QDFSQ 186

Query: 203 GGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILR 262
           G C   + ++W + E P SS AAR+    S+ F++VSI    L + E   +D  + EIL 
Sbjct: 187 GPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSIINMALMSAELSWLDLQLLEIL- 245

Query: 263 VGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAI 322
                                 E VC+ WFT EF++R +C  D   F++ + NIID +AI
Sbjct: 246 ----------------------EYVCISWFTGEFVLRFLCVRDRCRFLRKVPNIIDLLAI 283

Query: 323 LPFYLEVGLSGLS----SKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRAST 378
           LPFY+ + +  LS    ++   +V   ++V+R +R LR+ KL RH  GLR LG T+    
Sbjct: 284 LPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCY 343

Query: 379 NEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLG 438
            E  LL++FL++G+ IF+T+ Y+AE+     S P     T F ++P  +WWA  +MTT+G
Sbjct: 344 EEVGLLLLFLSVGISIFSTVEYFAEQ-----SIP----DTTFTSVPCAWWWATTSMTTVG 394

Query: 439 YGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRK 493
           YGD+ P T +G +V  +C L+G+L +A+P+ +I + F   Y     K+   ++R+
Sbjct: 395 YGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQRE 449


>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
           [Homo sapiens]
          Length = 494

 Score =  236 bits (603), Expect = 4e-62
 Identities = 159/470 (33%), Positives = 229/470 (48%), Gaps = 61/470 (12%)

Query: 37  KIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFF 96
           +I++NVGG R   Y   L   P TRLA L +   GG                 G  EF+F
Sbjct: 24  EIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTI----FSLCDDYDPGKREFYF 79

Query: 97  DRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEE 156
           DR P  F  V+  Y  G++H    +C   F+ E+ FW +D   ++ CC     + R+  E
Sbjct: 80  DRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELE 139

Query: 157 ALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALF 216
            +                        +L L  LG         A  G  R  Q  +W   
Sbjct: 140 EIA--------------------RRVQLILDDLGVD-------AAEGRWRRCQKCVWKFL 172

Query: 217 EDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVE 276
           E P SS  ARVVA  S   ILVS    C+ T     +      +   GN         VE
Sbjct: 173 EKPESSCPARVVAVLSFLLILVSSVVMCMGTIPELQV------LDAEGN--------RVE 218

Query: 277 TEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSS 336
             P L  +E  C+ WFTLE+L+R+   P+ L F  + +NI+D +AILPFY+ + L+ L +
Sbjct: 219 -HPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGA 277

Query: 337 KAAR--DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLI 394
           +     +V   ++ +R +RI RIFKL RH  GL+ L + L+ S  E  LL+++LA+G+ +
Sbjct: 278 RMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFV 337

Query: 395 FATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGA 454
           F+ + Y  E+          +  T FK+IP  FWWA++TMTT+GYGD+YPKT  G L  A
Sbjct: 338 FSALGYTMEQ---------SHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAA 388

Query: 455 LCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLES 504
           +  L GV+ IA+P+  I+NNF  YY+    KQ++ +   KH     +L S
Sbjct: 389 ISFLCGVIAIALPIHPIINNFVRYYN----KQRVLETAAKHELELMELNS 434


>gi|13492973 potassium voltage-gated channel delayed-rectifier
           protein S1 [Homo sapiens]
          Length = 526

 Score =  231 bits (588), Expect = 2e-60
 Identities = 147/453 (32%), Positives = 221/453 (48%), Gaps = 43/453 (9%)

Query: 34  ASEKIIINVGGTRHETYRSTLRTLPGTRLAWL--ADPDGGGRPETDGGGVGSSGSSGGGG 91
           + E + +NVGG R +     L   PGTRL  L  A  +   R   D     +        
Sbjct: 48  SDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAR------- 100

Query: 92  CEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQH 151
            EF+FDRHPG F  +L++YRTG LH   ++C   F +E  +WG+ E  +  CC   Y + 
Sbjct: 101 -EFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLER 159

Query: 152 RDAE-EALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQP 210
           R  +  A D  E  D   S     DE  D +RELA               G+  C   + 
Sbjct: 160 RLTQPHAWD--EDSDTPSSVDPCPDEISDVQRELARY-------------GAARCGRLRR 204

Query: 211 RMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVH 270
           R+W   E+P  S  +++ +  S+  +L SI   C+ +   +        +  V    S  
Sbjct: 205 RLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPE 264

Query: 271 FRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLE-- 328
             R+   +P+L  +E  C+ WF+ E   R++  P T +F  + LN+ID V++LPFYL   
Sbjct: 265 GVRD---DPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLL 321

Query: 329 --VGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 386
             V L     K    +   ++V R +RI R+ KL RH  GLR LG TL+ S  E  +L++
Sbjct: 322 AGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL 381

Query: 387 FLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKT 446
           +LA+GV +F+ + Y AE+           +   F  IP  +WW  V+MTT+GYGD+ P T
Sbjct: 382 YLAVGVSVFSGVAYTAEK----------EEDVGFNTIPACWWWGTVSMTTVGYGDVVPVT 431

Query: 447 WSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479
            +G L  + C L G+L +A+P+ +I N F  +Y
Sbjct: 432 VAGKLAASGCILGGILVVALPITIIFNKFSHFY 464


>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
           [Homo sapiens]
          Length = 513

 Score =  216 bits (551), Expect = 4e-56
 Identities = 150/471 (31%), Positives = 229/471 (48%), Gaps = 66/471 (14%)

Query: 20  PSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGG 79
           P + C  E+  +     +IIINVGG ++    +TL   P TRL  L       +  T+  
Sbjct: 52  PRQGCQPEDRRR-----RIIINVGGIKYSLPWTTLDEFPLTRLGQL-------KACTNFD 99

Query: 80  GVGSSGSSGGGGC-EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDET 138
            + +        C EFFFDR+PG F  +L + R GKL    ++C   F+EEL +WGI E 
Sbjct: 100 DILNVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAED 159

Query: 139 DVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGH 198
            ++ CC   Y Q    EE  ++ E  +         D+A D E        G    G   
Sbjct: 160 HLDGCCKRRYLQK--IEEFAEMVEREE--------EDDALDSE--------GRDSEGPAE 201

Query: 199 GAGS-GGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNV 257
           G G  G C     R+  + E P+S    +V A  S+ F+ V+     + T  +   +   
Sbjct: 202 GEGRLGRC---MRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQ 258

Query: 258 TEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNII 317
               ++ +   +              +E VCV WF+LEFL+R++  P    F+++ L +I
Sbjct: 259 GHCSQMCHNVFI--------------VESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLI 304

Query: 318 DFVAILPFYLEVGLSGLSSKAARDVLG---------FLRVVRFVRILRIFKLTRHFVGLR 368
           D VAILP+Y+ + + G ++   +   G          LRV+R +RIL + +L RH +GL+
Sbjct: 305 DLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQ 364

Query: 369 VLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFW 428
            LG T R  T EF LL++FL + + +FA ++Y  E   A        D  +F +IP  +W
Sbjct: 365 TLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMA--------DSPEFTSIPACYW 416

Query: 429 WAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479
           WAV+TMTT+GYGDM P++  G +V     L+G+L +A PV  I + F   Y
Sbjct: 417 WAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSY 467


>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
           subfamily S, member 2 [Homo sapiens]
          Length = 477

 Score =  213 bits (541), Expect = 6e-55
 Identities = 141/448 (31%), Positives = 216/448 (48%), Gaps = 53/448 (11%)

Query: 37  KIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFF 96
           +I INVGG +      TL   P TRL  L          +    +           EF+F
Sbjct: 18  EIRINVGGFKRRLRSHTLLRFPETRLGRLL------LCHSREAILELCDDYDDVQREFYF 71

Query: 97  DRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEE 156
           DR+P +F YVL++Y TGKLH  A++C   F +E+ +WGI+E  ++ CC  +Y   R  E 
Sbjct: 72  DRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSY-HGRKVEP 130

Query: 157 ALDIFESPDGGGSGAGPSDEA---GDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMW 213
             + ++      S     DE     +D  +   Q LG                 ++ ++W
Sbjct: 131 EQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLG----------------NFRRQLW 174

Query: 214 ALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRR 273
              ++P  S  +RV +  S+  ++ SI T CL +   F I  +               + 
Sbjct: 175 LALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDS---------------QG 219

Query: 274 EVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFY--LEVGL 331
               +P    +E   + WFT E + R    PD L F KN LN+ID ++I+PFY  L V L
Sbjct: 220 NPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNL 279

Query: 332 SGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 391
              S+    ++    +V+R +RI RI KL RH  GLR LG TL+ S  E  LL+++L++G
Sbjct: 280 VVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVG 339

Query: 392 VLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGML 451
           + IF+ + Y  E+           ++     IP  +WWA V+MTT+GYGD+ P T +G L
Sbjct: 340 ISIFSVVAYTIEK----------EENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKL 389

Query: 452 VGALCALAGVLTIAMPVPVIVNNFGMYY 479
             + C LAG+L + +P+ +I N F  +Y
Sbjct: 390 TASACILAGILVVVLPITLIFNKFSHFY 417


>gi|27436993 potassium voltage-gated channel, subfamily G, member 3
           isoform 2 [Homo sapiens]
          Length = 425

 Score =  210 bits (535), Expect = 3e-54
 Identities = 145/446 (32%), Positives = 221/446 (49%), Gaps = 55/446 (12%)

Query: 38  IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFD 97
           +++NVGG R+   R  L+  P  R++ L     G R E D   V           E+FFD
Sbjct: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLH----GCRSERDVLEVCDDYDRERN--EYFFD 64

Query: 98  RHPGVFAYVLNYYRT-GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEE 156
           RH   F ++L Y R  GKL     +C   F  E+ +WG++   +E CC    R+  D   
Sbjct: 65  RHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC---QRRLDDRMS 121

Query: 157 ALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALF 216
               F S D  G                    LG  E   G GA +   R W  RM   F
Sbjct: 122 DTYTFYSADEPGV-------------------LGRDEARPG-GAEAAPSRRWLERMRRTF 161

Query: 217 EDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVE 276
           E+P SS AA+++A  S+ F++VS+   C  T   +   RN     R     S+  R  + 
Sbjct: 162 EEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDW---RNAAADNR-----SLDDRSRI- 212

Query: 277 TEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLS---G 333
                  IE +C+ WFT E +VR +   +  +FVK  LNIID +AI P+Y+ V ++   G
Sbjct: 213 -------IEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTG 265

Query: 334 LSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVL 393
            +S+  R  +  LRV+R +RI  + KL RHF+GL+ LG TL+    E ++L++F+ + + 
Sbjct: 266 ENSQLQRAGVT-LRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMA 324

Query: 394 IFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVG 453
           IF+ +    E             + DF +IP   WW +++MTT+GYGDMYP T  G ++G
Sbjct: 325 IFSALSQLLEH-----GLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILG 379

Query: 454 ALCALAGVLTIAMPVPVIVNNFGMYY 479
            +C ++G++ +A+P+  I ++F   Y
Sbjct: 380 GVCVVSGIVLLALPITFIYHSFVQCY 405


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,132,718
Number of Sequences: 37866
Number of extensions: 1355607
Number of successful extensions: 8514
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 189
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 7106
Number of HSP's gapped (non-prelim): 1201
length of query: 626
length of database: 18,247,518
effective HSP length: 108
effective length of query: 518
effective length of database: 14,157,990
effective search space: 7333838820
effective search space used: 7333838820
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.