Search of human proteins with 84781739

Search of human proteins with 84781739

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|84781739 leucine-rich repeats and transmembrane domains 2
[Homo sapiens]
         (370 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho...   761   0.0  
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho...   219   3e-57
gi|52353306 leucine rich repeat containing 55 [Homo sapiens]          122   5e-28
gi|41582239 immunoglobulin superfamily containing leucine-rich r...   111   9e-25
gi|5031809 immunoglobulin superfamily containing leucine-rich re...   111   9e-25
gi|126517478 peroxidasin homolog-like [Homo sapiens]                  110   3e-24
gi|61966761 leucine rich repeat containing 26 [Homo sapiens]          109   4e-24
gi|4759146 slit homolog 2 [Homo sapiens]                              107   2e-23
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   106   3e-23
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   106   3e-23
gi|11321571 slit homolog 3 [Homo sapiens]                             105   6e-23
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]         104   1e-22
gi|188528675 slit homolog 1 [Homo sapiens]                            103   2e-22
gi|225579152 insulin-like growth factor binding protein, acid la...   100   2e-21
gi|4826772 insulin-like growth factor binding protein, acid labi...   100   2e-21
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor...   100   4e-21
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor...   100   4e-21
gi|13194201 reticulon 4 receptor precursor [Homo sapiens]              99   5e-21
gi|109150416 peroxidasin [Homo sapiens]                                98   1e-20
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre...    98   1e-20
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec...    98   1e-20
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                 97   3e-20
gi|194306623 immunoglobulin superfamily containing leucine-rich ...    95   1e-19
gi|194306621 immunoglobulin superfamily containing leucine-rich ...    95   1e-19
gi|39930401 immunoglobulin superfamily containing leucine-rich r...    95   1e-19
gi|194306618 immunoglobulin superfamily containing leucine-rich ...    95   1e-19
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]    93   3e-19
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho...    92   6e-19
gi|59823631 G protein-coupled receptor 125 [Homo sapiens]              92   7e-19
gi|157694513 leucine-rich repeat-containing G protein-coupled re...    92   7e-19

>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
           sapiens]
          Length = 370

 Score =  761 bits (1964), Expect = 0.0
 Identities = 370/370 (100%), Positives = 370/370 (100%)

Query: 1   MLAPGSSPGQRGRLALQWRQVSWITCWIALYAVEALPTCPFSCKCDSRSLEVDCSGLGLT 60
           MLAPGSSPGQRGRLALQWRQVSWITCWIALYAVEALPTCPFSCKCDSRSLEVDCSGLGLT
Sbjct: 1   MLAPGSSPGQRGRLALQWRQVSWITCWIALYAVEALPTCPFSCKCDSRSLEVDCSGLGLT 60

Query: 61  TVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTE 120
           TVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTE
Sbjct: 61  TVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTE 120

Query: 121 LQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLD 180
           LQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLD
Sbjct: 121 LQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLD 180

Query: 181 RLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMR 240
           RLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMR
Sbjct: 181 RLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMR 240

Query: 241 MVPMEMFNYCSQLEDENSSAGLDIPGPPCTKASPEPAKPKPGAEPEPEPSTACPQKQRHR 300
           MVPMEMFNYCSQLEDENSSAGLDIPGPPCTKASPEPAKPKPGAEPEPEPSTACPQKQRHR
Sbjct: 241 MVPMEMFNYCSQLEDENSSAGLDIPGPPCTKASPEPAKPKPGAEPEPEPSTACPQKQRHR 300

Query: 301 PASVRRAMGTVIIAGVVCGVVCIMMVVAAAYGCIYASLMAKYHRELKKRQPLMGDPEGEH 360
           PASVRRAMGTVIIAGVVCGVVCIMMVVAAAYGCIYASLMAKYHRELKKRQPLMGDPEGEH
Sbjct: 301 PASVRRAMGTVIIAGVVCGVVCIMMVVAAAYGCIYASLMAKYHRELKKRQPLMGDPEGEH 360

Query: 361 EDQKQISSVA 370
           EDQKQISSVA
Sbjct: 361 EDQKQISSVA 370


>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
           sapiens]
          Length = 345

 Score =  219 bits (558), Expect = 3e-57
 Identities = 119/311 (38%), Positives = 174/311 (55%), Gaps = 4/311 (1%)

Query: 33  VEALPTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLS 92
           ++ + +CP  C C S +  VDCS  GL  +P  +P  TRTL L +N++  LP++AF ++ 
Sbjct: 15  LQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVP 74

Query: 93  SLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGL 152
            L  L+LSNN L  L    F  L +L  L L  NS+ +L+  L    P LR LDLS N +
Sbjct: 75  WLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNI 134

Query: 153 AQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHW 212
           + LP  L +    L  L+++ N+LQ LDR   E + +++LL + DN W+C+C+L   K W
Sbjct: 135 SHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLW 194

Query: 213 MEWFSYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQLEDENSSAGLDIPGPPCTKA 272
           +E F Y+GG  D + C  P   +GKD+  +P E++  C     +  S+    PG     A
Sbjct: 195 LEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPG----SA 250

Query: 273 SPEPAKPKPGAEPEPEPSTACPQKQRHRPASVRRAMGTVIIAGVVCGVVCIMMVVAAAYG 332
                +P             C  K + RPA++R A+ TVII GVVCG+VC+MM+ AA YG
Sbjct: 251 HGVVLRPPENHNAGERELLECELKPKPRPANLRHAIATVIITGVVCGIVCLMMLAAAIYG 310

Query: 333 CIYASLMAKYH 343
           C YA++ A+YH
Sbjct: 311 CTYAAITAQYH 321


>gi|52353306 leucine rich repeat containing 55 [Homo sapiens]
          Length = 341

 Score =  122 bits (306), Expect = 5e-28
 Identities = 80/219 (36%), Positives = 106/219 (48%), Gaps = 4/219 (1%)

Query: 34  EALPTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSS 93
           +A  +CP  C C  R+  VDCS   L +VPPD+P  TR L L +N+++A+P         
Sbjct: 76  DAGTSCPVLCTC--RNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYME 133

Query: 94  LQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSIN-GL 152
           LQ LDL NN L  LPR +F     L  L L  N+   +  D+ + +  L H+DLS N  L
Sbjct: 134 LQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWL 193

Query: 153 AQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHW 212
            ++ P  F GL+ LR L L    L  L     E L  L  LQ+G NPW C C +     W
Sbjct: 194 RRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKW 253

Query: 213 MEWFSYRGGRLDQLA-CTLPKELRGKDMRMVPMEMFNYC 250
           +     R     QLA C  P E+ G  +  +  E F  C
Sbjct: 254 LRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKAC 292


>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score =  111 bits (278), Expect = 9e-25
 Identities = 78/232 (33%), Positives = 110/232 (47%), Gaps = 4/232 (1%)

Query: 39  CPFSCKCDSR-SLEV-DCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQR 96
           CP  C C  +   ++ DC+   L +VPP  PA   TL L  N+L  LP  AF  +  LQ 
Sbjct: 19  CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78

Query: 97  LDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLP 156
           L L++N +  +       L++L  L L +N I       L +   L+ L +  N L  +P
Sbjct: 79  LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138

Query: 157 PGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWF 216
              F  L ALRSL L  NRL  L   TF PL  L  LQ+ +NP++C C +   K W    
Sbjct: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTT 198

Query: 217 SYRGGRLDQLACTLPKELRGKDM-RMVPMEMFNYCSQLEDENSSAGLDI-PG 266
           +      D +ACT P  L+G  + R+ P+       QL  + S  G ++ PG
Sbjct: 199 AVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPG 250


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score =  111 bits (278), Expect = 9e-25
 Identities = 78/232 (33%), Positives = 110/232 (47%), Gaps = 4/232 (1%)

Query: 39  CPFSCKCDSR-SLEV-DCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQR 96
           CP  C C  +   ++ DC+   L +VPP  PA   TL L  N+L  LP  AF  +  LQ 
Sbjct: 19  CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78

Query: 97  LDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLP 156
           L L++N +  +       L++L  L L +N I       L +   L+ L +  N L  +P
Sbjct: 79  LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138

Query: 157 PGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWF 216
              F  L ALRSL L  NRL  L   TF PL  L  LQ+ +NP++C C +   K W    
Sbjct: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTT 198

Query: 217 SYRGGRLDQLACTLPKELRGKDM-RMVPMEMFNYCSQLEDENSSAGLDI-PG 266
           +      D +ACT P  L+G  + R+ P+       QL  + S  G ++ PG
Sbjct: 199 AVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPG 250


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score =  110 bits (274), Expect = 3e-24
 Identities = 72/225 (32%), Positives = 104/225 (46%), Gaps = 3/225 (1%)

Query: 26  CWIALYAVEA--LPTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSAL 83
           CW  L+ +    LP  P   +C      V C  L L  +P  VP  T  L L  N++  +
Sbjct: 7   CWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIP-QVPQQTTVLDLRFNRIREI 65

Query: 84  PSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLR 143
           P  AF  L +L  L L+NN + ++ R+ F  L NL  L L  N I  LD+   +    L 
Sbjct: 66  PGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLE 125

Query: 144 HLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECD 203
           HL +  N L  L P  F  LL L  L L +N+L  +   +F  L +L+ L++  N   CD
Sbjct: 126 HLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCD 185

Query: 204 CNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPMEMFN 248
           C+L      ++ F+  G       C  P+ L G+ +  V +E FN
Sbjct: 186 CDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFN 230


>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
          Length = 334

 Score =  109 bits (272), Expect = 4e-24
 Identities = 75/216 (34%), Positives = 94/216 (43%), Gaps = 1/216 (0%)

Query: 37  PTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQR 96
           P CP  C C    L   CS L L  VPP +    R LLL +N++ ALP  AFA   +LQR
Sbjct: 41  PDCPEVCTCVPGGL-ASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQR 99

Query: 97  LDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLP 156
           LDL  N L  +    F  L  L  L L  N +  L          LR+L L+ N LA+L 
Sbjct: 100 LDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLE 159

Query: 157 PGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWF 216
           P     L  LRSLSL+ N L  L       L  L  L +  NPW C C LR    W+   
Sbjct: 160 PAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRH 219

Query: 217 SYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQ 252
                  + + C  P  L    +       F++C+Q
Sbjct: 220 PLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQ 255


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score =  107 bits (267), Expect = 2e-23
 Identities = 70/217 (32%), Positives = 103/217 (47%), Gaps = 8/217 (3%)

Query: 39  CPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLD 98
           CP +C C +    VDC G GLT +P ++P     + L  N +  +P  AF+    L+R+D
Sbjct: 273 CPAACTCSNNI--VDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRID 330

Query: 99  LSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPG 158
           LSNN +  L    F  L +L  L L  N I  L + L      L+ L L+ N +  L   
Sbjct: 331 LSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVD 390

Query: 159 LFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWM-EWFS 217
            F  L  L  LSL  N+LQ + + TF PL  +Q + +  NP+ CDC+L+    W+ ++  
Sbjct: 391 AFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLK----WLADYLH 446

Query: 218 YRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQLE 254
                     CT P+ L  K +  +  + F  CS  E
Sbjct: 447 TNPIETSGARCTSPRRLANKRIGQIKSKKFR-CSAKE 482



 Score = 95.1 bits (235), Expect = 9e-20
 Identities = 73/259 (28%), Positives = 108/259 (41%), Gaps = 35/259 (13%)

Query: 19  RQVSWITCWIALYAVEAL------PTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAAT-- 70
           R V W    ++L  V A+        CP  C C   +  VDC GL L +VP ++P  T  
Sbjct: 2   RGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGST--VDCHGLALRSVPRNIPRNTER 59

Query: 71  ----------------------RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLP 108
                                 R L L+ NK+S +   AF +L  L+RL L+ N L   P
Sbjct: 60  LDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFP 119

Query: 109 RSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRS 168
             +F     L  L L  N I+ + R   R +  +++L L  N ++ +  G F  L  L  
Sbjct: 120 ELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEV 179

Query: 169 LSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLAC 228
           L+L +N +  L   +F  +  L+  ++  N   CDC+L     W+     R G   Q  C
Sbjct: 180 LTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQ-RPRVGLYTQ--C 236

Query: 229 TLPKELRGKDMRMVPMEMF 247
             P  LRG ++  V    F
Sbjct: 237 MGPSHLRGHNVAEVQKREF 255



 Score = 85.9 bits (211), Expect = 5e-17
 Identities = 63/234 (26%), Positives = 107/234 (45%), Gaps = 9/234 (3%)

Query: 39  CPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWA-FANLSSLQRL 97
           CP  C+C+  +  VDCS   L  +P  +P  T  L L NN+ + L +   F  L  L+++
Sbjct: 506 CPEKCRCEGTT--VDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKI 563

Query: 98  DLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPP 157
           + SNN +  +    F   + + E+ L +N +  +   + +    L+ L L  N +  +  
Sbjct: 564 NFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGN 623

Query: 158 GLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWM-EWF 216
             F GL ++R LSL  N++  +    F+ L +L  L +  NP+ C+C L     W+ EW 
Sbjct: 624 DSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLA----WLGEWL 679

Query: 217 SYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQLEDENSSAGLDIPGPPCT 270
             +        C  P  L+   ++ V ++ F  C    D+NS + L      CT
Sbjct: 680 RKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFT-CDDGNDDNSCSPLSRCPTECT 732



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 62/212 (29%), Positives = 89/212 (41%), Gaps = 30/212 (14%)

Query: 36  LPTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQ 95
           L  CP  C C      V CS  GL  +P  +P     L L  N+ + +P    +N   L 
Sbjct: 724 LSRCPTECTC--LDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK-ELSNYKHLT 780

Query: 96  RLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQL 155
            +DLSNN +  L    F ++T L  L L  N +R +                        
Sbjct: 781 LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCI------------------------ 816

Query: 156 PPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEW 215
           PP  FDGL +LR LSL  N +  +    F  L+ L  L +G NP  CDCN++    W++ 
Sbjct: 817 PPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVK- 875

Query: 216 FSYRGGRLDQLACTLPKELRGKDMRMVPMEMF 247
             Y+   + +  C  P E+  K +   P + F
Sbjct: 876 SEYKEPGIAR--CAGPGEMADKLLLTTPSKKF 905


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  106 bits (265), Expect = 3e-23
 Identities = 79/268 (29%), Positives = 127/268 (47%), Gaps = 7/268 (2%)

Query: 71  RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRT 130
           R L L +N +S+LP   F+NL  LQ L LS N +  +    F  LT L EL L  N+++ 
Sbjct: 302 RELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQD 361

Query: 131 LDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANL 190
           LD ++ R    L+++ L  N L QLP  +F  +  L ++ L++N+L+NL    F+ L  L
Sbjct: 362 LDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKL 421

Query: 191 QLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYC 250
             L++ DNPW CD ++   ++W+     R G      C  P  +RG+ + ++ + +    
Sbjct: 422 CELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPS 481

Query: 251 SQLEDENSSAGLDIPGPPCTKASPEPAKPKPGAE--PEPEPSTACPQKQRHRPASV---R 305
             + +  S    + P  P T + P+        E     E  T     Q     SV    
Sbjct: 482 VHVPEVPSYP--ETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMT 539

Query: 306 RAMGTVIIAGVVCGVVCIMMVVAAAYGC 333
           +A   + IA +V G+V +   +AA  GC
Sbjct: 540 QAQSGLAIAAIVIGIVALACSLAACVGC 567



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 59/184 (32%), Positives = 87/184 (47%), Gaps = 25/184 (13%)

Query: 39  CPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLN--------------------- 77
           CP  C C SR+ +V+C+G  +  VP  +P    +L +LN                     
Sbjct: 31  CPSECTC-SRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALR 89

Query: 78  ---NKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRD 134
              N+LS +   AF NL SL+ L L+NN L  LP  +F  L +L  L L +N +  +   
Sbjct: 90  IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 149

Query: 135 LLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQ 194
                  L+ L L  N L  +P G FD L+ L  L+L  N L ++    F+ L NLQ+L+
Sbjct: 150 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 209

Query: 195 VGDN 198
           + +N
Sbjct: 210 LYEN 213



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 44/127 (34%), Positives = 68/127 (53%)

Query: 72  TLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTL 131
           +LLL +N+L  +    F+  S+L+ L L  N L+ +P   F  L  LT+L L  NS+  +
Sbjct: 135 SLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHI 194

Query: 132 DRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQ 191
              + +H   L+ L L  N L  +P G FDGL+ L+ L+L+ N++  L    F    NLQ
Sbjct: 195 SPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQ 254

Query: 192 LLQVGDN 198
            L + +N
Sbjct: 255 RLYLSNN 261



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 48/126 (38%), Positives = 65/126 (51%)

Query: 73  LLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLD 132
           L L  N L+ +    F +L +LQ L L  N L  +P   F  L NL EL L+ N I  L 
Sbjct: 184 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 243

Query: 133 RDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQL 192
             L  ++  L+ L LS N ++QLPP +F  L  L  L+L  N L+ L    F P+ NL+ 
Sbjct: 244 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 303

Query: 193 LQVGDN 198
           L + DN
Sbjct: 304 LWLYDN 309



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 29/69 (42%), Positives = 39/69 (56%), Gaps = 1/69 (1%)

Query: 68  AATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNS 127
           A  + + L NN+L  LP   FAN++ L  + L NN L+ LP  IF  L  L EL+L +N 
Sbjct: 371 ANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNP 430

Query: 128 IRTLDRDLL 136
            R  D D+L
Sbjct: 431 WR-CDSDIL 438


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  106 bits (265), Expect = 3e-23
 Identities = 79/268 (29%), Positives = 127/268 (47%), Gaps = 7/268 (2%)

Query: 71  RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRT 130
           R L L +N +S+LP   F+NL  LQ L LS N +  +    F  LT L EL L  N+++ 
Sbjct: 296 RELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQD 355

Query: 131 LDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANL 190
           LD ++ R    L+++ L  N L QLP  +F  +  L ++ L++N+L+NL    F+ L  L
Sbjct: 356 LDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKL 415

Query: 191 QLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYC 250
             L++ DNPW CD ++   ++W+     R G      C  P  +RG+ + ++ + +    
Sbjct: 416 CELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPS 475

Query: 251 SQLEDENSSAGLDIPGPPCTKASPEPAKPKPGAE--PEPEPSTACPQKQRHRPASV---R 305
             + +  S    + P  P T + P+        E     E  T     Q     SV    
Sbjct: 476 VHVPEVPSYP--ETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMT 533

Query: 306 RAMGTVIIAGVVCGVVCIMMVVAAAYGC 333
           +A   + IA +V G+V +   +AA  GC
Sbjct: 534 QAQSGLAIAAIVIGIVALACSLAACVGC 561



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 59/184 (32%), Positives = 87/184 (47%), Gaps = 25/184 (13%)

Query: 39  CPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLN--------------------- 77
           CP  C C SR+ +V+C+G  +  VP  +P    +L +LN                     
Sbjct: 25  CPSECTC-SRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALR 83

Query: 78  ---NKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRD 134
              N+LS +   AF NL SL+ L L+NN L  LP  +F  L +L  L L +N +  +   
Sbjct: 84  IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143

Query: 135 LLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQ 194
                  L+ L L  N L  +P G FD L+ L  L+L  N L ++    F+ L NLQ+L+
Sbjct: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 203

Query: 195 VGDN 198
           + +N
Sbjct: 204 LYEN 207



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 44/127 (34%), Positives = 68/127 (53%)

Query: 72  TLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTL 131
           +LLL +N+L  +    F+  S+L+ L L  N L+ +P   F  L  LT+L L  NS+  +
Sbjct: 129 SLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHI 188

Query: 132 DRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQ 191
              + +H   L+ L L  N L  +P G FDGL+ L+ L+L+ N++  L    F    NLQ
Sbjct: 189 SPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQ 248

Query: 192 LLQVGDN 198
            L + +N
Sbjct: 249 RLYLSNN 255



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 48/126 (38%), Positives = 65/126 (51%)

Query: 73  LLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLD 132
           L L  N L+ +    F +L +LQ L L  N L  +P   F  L NL EL L+ N I  L 
Sbjct: 178 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 237

Query: 133 RDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQL 192
             L  ++  L+ L LS N ++QLPP +F  L  L  L+L  N L+ L    F P+ NL+ 
Sbjct: 238 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 297

Query: 193 LQVGDN 198
           L + DN
Sbjct: 298 LWLYDN 303



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 29/69 (42%), Positives = 39/69 (56%), Gaps = 1/69 (1%)

Query: 68  AATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNS 127
           A  + + L NN+L  LP   FAN++ L  + L NN L+ LP  IF  L  L EL+L +N 
Sbjct: 365 ANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNP 424

Query: 128 IRTLDRDLL 136
            R  D D+L
Sbjct: 425 WR-CDSDIL 432


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score =  105 bits (262), Expect = 6e-23
 Identities = 68/222 (30%), Positives = 105/222 (47%), Gaps = 8/222 (3%)

Query: 38  TCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRL 97
           +CP  C C +    VDC G GL  +P ++P     + L  N + A+P+ AF     L+R+
Sbjct: 279 SCPSPCTCSNNI--VDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRI 336

Query: 98  DLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPP 157
           D+S N +  +    F  L +LT L L  N I  + + L      L+ L L+ N +  L  
Sbjct: 337 DISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRV 396

Query: 158 GLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWM-EWF 216
             F  L  L  LSL  N+LQ + +  F PL ++Q L +  NP+ CDC+L+    W+ ++ 
Sbjct: 397 NTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLK----WLADYL 452

Query: 217 SYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQLEDENS 258
                      C+ P+ L  K +  +  + F  CS  ED  S
Sbjct: 453 QDNPIETSGARCSSPRRLANKRISQIKSKKFR-CSGSEDYRS 493



 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 82/295 (27%), Positives = 124/295 (42%), Gaps = 45/295 (15%)

Query: 5   GSSPGQRGRLALQWRQVSWITCWIALYAVEALP---TCPFSCKCDSRSLEVDCSGLGLTT 61
           G     R RLAL           +AL +V + P    CP  C C + S  VDC GLGL  
Sbjct: 7   GVGAAVRARLALA----------LALASVLSGPPAVACPTKCTCSAAS--VDCHGLGLRA 54

Query: 62  VPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTEL 121
           VP  +P     L L  N ++ +    FA L +L+ L L +N +  + R  F DL  L  L
Sbjct: 55  VPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERL 114

Query: 122 QLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDR 181
           +L  N ++ L   L + +P L  LDLS N +  +P   F G+  +++L L +N +  ++ 
Sbjct: 115 RLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIED 174

Query: 182 LTFEPLANLQLLQVGDNPWE------------------------CDCNLREFKHWM-EWF 216
             F  L +L++L + +N                           CDC+L     W+ +W 
Sbjct: 175 GAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLA----WLSDWL 230

Query: 217 SYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQLEDENSSAGLDIPGP-PCT 270
             R        C  P  LRG ++  V  + +   +   +  S     I  P PCT
Sbjct: 231 RQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCT 285



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 52/176 (29%), Positives = 86/176 (48%), Gaps = 3/176 (1%)

Query: 39  CPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWA-FANLSSLQRL 97
           CP  C+C+     VDCS   L  +P  +P     L L +N++S L +   F  L +L+++
Sbjct: 505 CPEKCRCEGTI--VDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKI 562

Query: 98  DLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPP 157
           +LSNN +  +    F    ++ EL L  N + T+   + R    L+ L L  N +  +  
Sbjct: 563 NLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSN 622

Query: 158 GLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWM 213
             F GL ++R LSL  NR+  +    F  L +L  + +  NP+ C+C+L     W+
Sbjct: 623 DTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWL 678



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 72/270 (26%), Positives = 109/270 (40%), Gaps = 40/270 (14%)

Query: 37  PTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQR 96
           P CP  C C      V CS  GL  +P  +P     L L  N L+A+P    A L  L  
Sbjct: 723 PRCPEQCTC--METVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSA-LRHLTL 779

Query: 97  LDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLP 156
           +DLSNN +  L    F ++++L+ L L  N +R +                        P
Sbjct: 780 IDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCI------------------------P 815

Query: 157 PGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWF 216
              F+GL +LR L+L  N + ++   +F  L +L  L +G NP  CDC+LR    W++  
Sbjct: 816 VHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK-A 874

Query: 217 SYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQLEDENSSAGLDIPGPPCTKASPEP 276
            Y+   + +  C+ P+ +  + +   P   F  C    D N  A        C      P
Sbjct: 875 GYKEPGIAR--CSSPEPMADRLLLTTPTHRFQ-CKGPVDINIVA-------KCNACLSSP 924

Query: 277 AKPKPGAEPEPEP--STACPQKQRHRPASV 304
            K       +P      ACP   + +  +V
Sbjct: 925 CKNNGTCTQDPVELYRCACPYSYKGKDCTV 954


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score =  104 bits (260), Expect = 1e-22
 Identities = 73/210 (34%), Positives = 99/210 (47%), Gaps = 31/210 (14%)

Query: 39  CPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLD 98
           CP +C+C S ++E  C  L L  VP  +P  T+TL L +N ++ L   A A L++L+RL 
Sbjct: 23  CPAACRCYSATVE--CGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLY 80

Query: 99  LSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTL-----------------DRDLLR---- 137
           L NN L  L    F     L EL L +N +R L                    L R    
Sbjct: 81  LHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDF 140

Query: 138 ---HSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQ 194
              H P L+ L L  N +  L      GL +L  L L  N+L  + R   +PLA+LQ+L+
Sbjct: 141 TFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLR 200

Query: 195 VGDNPWECDCNLREFKHWM-EWFSYRGGRL 223
           + +NPW CDC L    HW+  W    G RL
Sbjct: 201 LTENPWRCDCAL----HWLGAWIKEGGQRL 226


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  103 bits (258), Expect = 2e-22
 Identities = 82/286 (28%), Positives = 123/286 (43%), Gaps = 21/286 (7%)

Query: 38  TCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRL 97
           +CP  C C +    VDC G GLT +P ++P     + L  N + ++P  AF+    L+R+
Sbjct: 281 SCPAMCTCSNGI--VDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRI 338

Query: 98  DLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPP 157
           DLSNN +  +    F  L +L  L L  N I  L R +      L+ L L+ N +  + P
Sbjct: 339 DLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRP 398

Query: 158 GLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWM-EWF 216
             F  L  L  LSL  N++Q+L + TF  L  +Q L +  NP+ CDCNL+    W+ ++ 
Sbjct: 399 DAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLK----WLADFL 454

Query: 217 SYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQLEDE----------NSSAGLDIPG 266
                      C  P+ L  K +  +  + F  CS  E            NS    D+  
Sbjct: 455 RTNPIETSGARCASPRRLANKRIGQIKSKKFR-CSAKEQYFIPGTEDYQLNSECNSDVVC 513

Query: 267 P---PCTKASPEPAKPKPGAEPEPEPSTACPQKQRHRPASVRRAMG 309
           P    C     E +  K    PE  P +    +  +   S+  A G
Sbjct: 514 PHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATG 559



 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 69/256 (26%), Positives = 111/256 (43%), Gaps = 30/256 (11%)

Query: 23  WITCWIALYAVEALPTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAAT------------ 70
           W+  W A + + A   CP  C C   +  VDC G GL  +P ++P  T            
Sbjct: 19  WLLLWAAAWRLGA-SACPALCTCTGTT--VDCHGTGLQAIPKNIPRNTERLELNGNNITR 75

Query: 71  ------------RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNL 118
                       R L L+ N++ A+   AF ++  L+RL L+ N L  LP  +F +   L
Sbjct: 76  IHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQAL 135

Query: 119 TELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQN 178
           + L L  N+I+ + R   R +  L++L L  N ++ +  G F  L  L  L+L +N +  
Sbjct: 136 SRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITT 195

Query: 179 LDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKD 238
           +   +F  +  L+  ++  N   CDC+L     W+      G       C+ P  LRG +
Sbjct: 196 IPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQ---CSGPASLRGLN 252

Query: 239 MRMVPMEMFNYCSQLE 254
           +  V    F+   Q E
Sbjct: 253 VAEVQKSEFSCSGQGE 268



 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 64/232 (27%), Positives = 111/232 (47%), Gaps = 11/232 (4%)

Query: 39  CPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWA-FANLSSLQRL 97
           CP  C+C++  +E  CS L LT +P  +P +T  L L NN++S L +   F  L+ L+++
Sbjct: 513 CPHKCRCEANVVE--CSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKI 570

Query: 98  DLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPP 157
           +LSNN +  +    F    +++EL L  N + ++   + R    LR L L  N ++ +  
Sbjct: 571 NLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHN 630

Query: 158 GLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFS 217
             F GL  +R LSL  N++  +    F+ L +L  L +  NP+ C+C L     W+    
Sbjct: 631 DSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWL---- 686

Query: 218 YRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQLEDENSSAGLDIPGPPC 269
               R  ++    P+      +R +P++   +     +E    G  +P P C
Sbjct: 687 ----RKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQC 734



 Score = 85.5 bits (210), Expect = 7e-17
 Identities = 63/211 (29%), Positives = 91/211 (43%), Gaps = 30/211 (14%)

Query: 37  PTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQR 96
           P CP  C C      V CS   L  +P  +P     L L  N+ + +P    +    LQ 
Sbjct: 732 PQCPQECAC--LDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPG-QLSTFKYLQL 788

Query: 97  LDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLP 156
           +DLSNN +  L  S F +++ LT L L                        S N L  +P
Sbjct: 789 VDLSNNKISSLSNSSFTNMSQLTTLIL------------------------SYNALQCIP 824

Query: 157 PGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWF 216
           P  F GL +LR LSL  N +  L    F  + +L  L +G NP  CDC+LR    W++  
Sbjct: 825 PLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK-T 883

Query: 217 SYRGGRLDQLACTLPKELRGKDMRMVPMEMF 247
            Y+   + +  C  P+++ GK +   P + F
Sbjct: 884 GYKEPGIAR--CAGPQDMEGKLLLTTPAKKF 912


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score =  100 bits (249), Expect = 2e-21
 Identities = 68/167 (40%), Positives = 89/167 (53%), Gaps = 6/167 (3%)

Query: 37  PTCPFSCKC----DSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLS 92
           P CP +C C    D+  L V CS   LT +P  VP  T+ L L  N LS++P  AF NLS
Sbjct: 77  PACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLS 136

Query: 93  SLQRLDLSNNFLDRL-PRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSING 151
           SL  L+L    L  L P+++ G L NL  L L  N +R+L      H+P L  L LS N 
Sbjct: 137 SLGFLNLQGGQLGSLEPQALLG-LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNR 195

Query: 152 LAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDN 198
           L++L  GLF+GL +L  L+L  N L  L    F  L +L+ L +  N
Sbjct: 196 LSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGN 242



 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 56/152 (36%), Positives = 77/152 (50%), Gaps = 3/152 (1%)

Query: 78  NKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLR 137
           N L+ LP  AF  L SL+ L L+ N L  L  ++F  L  L EL L  N++R +  ++  
Sbjct: 218 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV 277

Query: 138 HSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGD 197
             P L+ L L  N +A + PG F GL ALR L L  NR+  L   TF  L  L++L++  
Sbjct: 278 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 337

Query: 198 NPWECDCNLREFK--HWMEWFSYRGGRLDQLA 227
           N        R FK  H++E       R+ QLA
Sbjct: 338 NA-IASLRPRTFKDLHFLEELQLGHNRIRQLA 368



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 49/128 (38%), Positives = 66/128 (51%)

Query: 71  RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRT 130
           R L+L  N+L+ L    F+ L+ L+ LDLS N L  +  ++F  L  L +L L  N I  
Sbjct: 235 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAA 294

Query: 131 LDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANL 190
           +          LR LDLS N +A L    F GLL LR L L  N + +L   TF+ L  L
Sbjct: 295 VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFL 354

Query: 191 QLLQVGDN 198
           + LQ+G N
Sbjct: 355 EELQLGHN 362



 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 54/143 (37%), Positives = 70/143 (48%), Gaps = 10/143 (6%)

Query: 71  RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRT 130
           R L L +N L  +   +   L+ L  LDL++N L  LP  +F  L  L  L L  N +  
Sbjct: 451 RRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAE 510

Query: 131 LDRDLLRHSPLLRH--LDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPL- 187
           L  D L   PL R   LD+S N L  LP  L   L  LR LSLR+N L+     TF P  
Sbjct: 511 LPADAL--GPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR-----TFTPQP 563

Query: 188 ANLQLLQVGDNPWECDCNLREFK 210
             L+ L +  NPW+C C L+  +
Sbjct: 564 PGLERLWLEGNPWDCGCPLKALR 586



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 45/136 (33%), Positives = 66/136 (48%), Gaps = 3/136 (2%)

Query: 73  LLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLD 132
           L L  N ++A+   AF  L +L+ LDLS+N +  L    F  L  L  L+L +N+I +L 
Sbjct: 285 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR 344

Query: 133 RDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQL 192
               +    L  L L  N + QL    F+GL  L  L+L  N+LQ +    F  L N+ +
Sbjct: 345 PRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAV 404

Query: 193 LQVGDNPWECDCNLRE 208
           + +  N   C  NL E
Sbjct: 405 MNLSGN---CLRNLPE 417



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 49/145 (33%), Positives = 59/145 (40%), Gaps = 8/145 (5%)

Query: 57  LGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLT 116
           LGLT V          + L  N L  LP   F  L  L  L L  + L R+    F  L+
Sbjct: 397 LGLTNVA--------VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLS 448

Query: 117 NLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRL 176
            L  L L++N +  ++   L     L  LDL+ N L  LP  LF GL  L  L L  NRL
Sbjct: 449 GLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 508

Query: 177 QNLDRLTFEPLANLQLLQVGDNPWE 201
             L      PL     L V  N  E
Sbjct: 509 AELPADALGPLQRAFWLDVSHNRLE 533



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 44/127 (34%), Positives = 59/127 (46%)

Query: 69  ATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSI 128
           A R L L +N+++ L    F  L  L+ L LS+N +  L    F DL  L ELQL +N I
Sbjct: 305 ALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRI 364

Query: 129 RTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLA 188
           R L          L  L L  N L ++  G F GL  +  ++L  N L+NL    F  L 
Sbjct: 365 RQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLG 424

Query: 189 NLQLLQV 195
            L  L +
Sbjct: 425 KLHSLHL 431



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 39/126 (30%), Positives = 58/126 (46%)

Query: 73  LLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLD 132
           L L +N+L  + + AF  L+++  ++LS N L  LP  +F  L  L  L L  + +  + 
Sbjct: 381 LTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIR 440

Query: 133 RDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQL 192
                    LR L L  NGL  +      GL  L  L L SN+L +L    F+ L  L+ 
Sbjct: 441 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEY 500

Query: 193 LQVGDN 198
           L +  N
Sbjct: 501 LLLSRN 506


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score =  100 bits (249), Expect = 2e-21
 Identities = 68/167 (40%), Positives = 89/167 (53%), Gaps = 6/167 (3%)

Query: 37  PTCPFSCKC----DSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLS 92
           P CP +C C    D+  L V CS   LT +P  VP  T+ L L  N LS++P  AF NLS
Sbjct: 39  PACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLS 98

Query: 93  SLQRLDLSNNFLDRL-PRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSING 151
           SL  L+L    L  L P+++ G L NL  L L  N +R+L      H+P L  L LS N 
Sbjct: 99  SLGFLNLQGGQLGSLEPQALLG-LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNR 157

Query: 152 LAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDN 198
           L++L  GLF+GL +L  L+L  N L  L    F  L +L+ L +  N
Sbjct: 158 LSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGN 204



 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 56/152 (36%), Positives = 77/152 (50%), Gaps = 3/152 (1%)

Query: 78  NKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLR 137
           N L+ LP  AF  L SL+ L L+ N L  L  ++F  L  L EL L  N++R +  ++  
Sbjct: 180 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV 239

Query: 138 HSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGD 197
             P L+ L L  N +A + PG F GL ALR L L  NR+  L   TF  L  L++L++  
Sbjct: 240 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 299

Query: 198 NPWECDCNLREFK--HWMEWFSYRGGRLDQLA 227
           N        R FK  H++E       R+ QLA
Sbjct: 300 NA-IASLRPRTFKDLHFLEELQLGHNRIRQLA 330



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 49/128 (38%), Positives = 66/128 (51%)

Query: 71  RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRT 130
           R L+L  N+L+ L    F+ L+ L+ LDLS N L  +  ++F  L  L +L L  N I  
Sbjct: 197 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAA 256

Query: 131 LDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANL 190
           +          LR LDLS N +A L    F GLL LR L L  N + +L   TF+ L  L
Sbjct: 257 VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFL 316

Query: 191 QLLQVGDN 198
           + LQ+G N
Sbjct: 317 EELQLGHN 324



 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 54/143 (37%), Positives = 70/143 (48%), Gaps = 10/143 (6%)

Query: 71  RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRT 130
           R L L +N L  +   +   L+ L  LDL++N L  LP  +F  L  L  L L  N +  
Sbjct: 413 RRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAE 472

Query: 131 LDRDLLRHSPLLRH--LDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPL- 187
           L  D L   PL R   LD+S N L  LP  L   L  LR LSLR+N L+     TF P  
Sbjct: 473 LPADAL--GPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR-----TFTPQP 525

Query: 188 ANLQLLQVGDNPWECDCNLREFK 210
             L+ L +  NPW+C C L+  +
Sbjct: 526 PGLERLWLEGNPWDCGCPLKALR 548



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 45/136 (33%), Positives = 66/136 (48%), Gaps = 3/136 (2%)

Query: 73  LLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLD 132
           L L  N ++A+   AF  L +L+ LDLS+N +  L    F  L  L  L+L +N+I +L 
Sbjct: 247 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR 306

Query: 133 RDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQL 192
               +    L  L L  N + QL    F+GL  L  L+L  N+LQ +    F  L N+ +
Sbjct: 307 PRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAV 366

Query: 193 LQVGDNPWECDCNLRE 208
           + +  N   C  NL E
Sbjct: 367 MNLSGN---CLRNLPE 379



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 49/145 (33%), Positives = 59/145 (40%), Gaps = 8/145 (5%)

Query: 57  LGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLT 116
           LGLT V          + L  N L  LP   F  L  L  L L  + L R+    F  L+
Sbjct: 359 LGLTNVA--------VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLS 410

Query: 117 NLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRL 176
            L  L L++N +  ++   L     L  LDL+ N L  LP  LF GL  L  L L  NRL
Sbjct: 411 GLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 470

Query: 177 QNLDRLTFEPLANLQLLQVGDNPWE 201
             L      PL     L V  N  E
Sbjct: 471 AELPADALGPLQRAFWLDVSHNRLE 495



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 44/127 (34%), Positives = 59/127 (46%)

Query: 69  ATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSI 128
           A R L L +N+++ L    F  L  L+ L LS+N +  L    F DL  L ELQL +N I
Sbjct: 267 ALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRI 326

Query: 129 RTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLA 188
           R L          L  L L  N L ++  G F GL  +  ++L  N L+NL    F  L 
Sbjct: 327 RQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLG 386

Query: 189 NLQLLQV 195
            L  L +
Sbjct: 387 KLHSLHL 393



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 39/126 (30%), Positives = 58/126 (46%)

Query: 73  LLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLD 132
           L L +N+L  + + AF  L+++  ++LS N L  LP  +F  L  L  L L  + +  + 
Sbjct: 343 LTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIR 402

Query: 133 RDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQL 192
                    LR L L  NGL  +      GL  L  L L SN+L +L    F+ L  L+ 
Sbjct: 403 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEY 462

Query: 193 LQVGDN 198
           L +  N
Sbjct: 463 LLLSRN 468


>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
           [Homo sapiens]
          Length = 518

 Score = 99.8 bits (247), Expect = 4e-21
 Identities = 87/306 (28%), Positives = 142/306 (46%), Gaps = 22/306 (7%)

Query: 59  LTTVPPDVPAATRTLLLLN---NKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDL 115
           L TVP  V    R L  L+   N+L +L   AFA L  L+ L L +N   ++  + F  L
Sbjct: 169 LKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRL 228

Query: 116 TNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNR 175
            NL  + L+ N IR++ + L      L +LDLS N +  + PG F  L  L+ L+L SN+
Sbjct: 229 FNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNK 288

Query: 176 LQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELR 235
           L N+ + T     +L  + +  N WEC  ++    +W++  +++G +   + C  PK ++
Sbjct: 289 LTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLK--NFKGNKESTMICAGPKHIQ 346

Query: 236 GKDMRMVPMEMFNYCSQLEDENSSAGLDIPGPPCTK-ASPEPAKPKPGA------EPEPE 288
           G+ +    +E +N CS+++  N+     +P  P      P P   KP         P P 
Sbjct: 347 GEKVSDA-VETYNICSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPS 405

Query: 289 PSTACP-QKQRHRPASVRRAMGTVIIAGVVC---GVVCIMMVVAAAYGCIYASLMAKYHR 344
           P    P  +Q +   S  +     IIAG V     V  I++V+  ++    AS+      
Sbjct: 406 PGFQIPGAEQEYEHVSFHK-----IIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQH 460

Query: 345 ELKKRQ 350
            L KR+
Sbjct: 461 SLMKRR 466



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 54/160 (33%), Positives = 75/160 (46%), Gaps = 2/160 (1%)

Query: 39  CPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLD 98
           CP +C+CD +   V C       +P ++   ++ L L  N +  L S  FA L+ L  L 
Sbjct: 34  CPKNCRCDGKI--VYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLY 91

Query: 99  LSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPG 158
           L +N++  +    F  +  L EL L +N I  L        P LR+LDLS N L  L   
Sbjct: 92  LDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE 151

Query: 159 LFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDN 198
            F GL  L  L LRSN L+ +    F+   NL  L +G N
Sbjct: 152 QFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYN 191



 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 42/121 (34%), Positives = 62/121 (51%)

Query: 71  RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRT 130
           + L+L +NK++ L +  F  + +L+ LDLS N L  L    F  L  L  L LR+NS++T
Sbjct: 112 KELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKT 171

Query: 131 LDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANL 190
           +   + +    L  LDL  N L  L    F GLL L+ L L  N+   ++   F  L NL
Sbjct: 172 VPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNL 231

Query: 191 Q 191
           +
Sbjct: 232 R 232


>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
           [Homo sapiens]
          Length = 590

 Score = 99.8 bits (247), Expect = 4e-21
 Identities = 87/306 (28%), Positives = 142/306 (46%), Gaps = 22/306 (7%)

Query: 59  LTTVPPDVPAATRTLLLLN---NKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDL 115
           L TVP  V    R L  L+   N+L +L   AFA L  L+ L L +N   ++  + F  L
Sbjct: 169 LKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRL 228

Query: 116 TNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNR 175
            NL  + L+ N IR++ + L      L +LDLS N +  + PG F  L  L+ L+L SN+
Sbjct: 229 FNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNK 288

Query: 176 LQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELR 235
           L N+ + T     +L  + +  N WEC  ++    +W++  +++G +   + C  PK ++
Sbjct: 289 LTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLK--NFKGNKESTMICAGPKHIQ 346

Query: 236 GKDMRMVPMEMFNYCSQLEDENSSAGLDIPGPPCTK-ASPEPAKPKPGA------EPEPE 288
           G+ +    +E +N CS+++  N+     +P  P      P P   KP         P P 
Sbjct: 347 GEKVSDA-VETYNICSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPS 405

Query: 289 PSTACP-QKQRHRPASVRRAMGTVIIAGVVC---GVVCIMMVVAAAYGCIYASLMAKYHR 344
           P    P  +Q +   S  +     IIAG V     V  I++V+  ++    AS+      
Sbjct: 406 PGFQIPGAEQEYEHVSFHK-----IIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQH 460

Query: 345 ELKKRQ 350
            L KR+
Sbjct: 461 SLMKRR 466



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 54/160 (33%), Positives = 75/160 (46%), Gaps = 2/160 (1%)

Query: 39  CPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLD 98
           CP +C+CD +   V C       +P ++   ++ L L  N +  L S  FA L+ L  L 
Sbjct: 34  CPKNCRCDGKI--VYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLY 91

Query: 99  LSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPG 158
           L +N++  +    F  +  L EL L +N I  L        P LR+LDLS N L  L   
Sbjct: 92  LDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSE 151

Query: 159 LFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDN 198
            F GL  L  L LRSN L+ +    F+   NL  L +G N
Sbjct: 152 QFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYN 191



 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 42/121 (34%), Positives = 62/121 (51%)

Query: 71  RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRT 130
           + L+L +NK++ L +  F  + +L+ LDLS N L  L    F  L  L  L LR+NS++T
Sbjct: 112 KELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKT 171

Query: 131 LDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANL 190
           +   + +    L  LDL  N L  L    F GLL L+ L L  N+   ++   F  L NL
Sbjct: 172 VPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNL 231

Query: 191 Q 191
           +
Sbjct: 232 R 232


>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score = 99.4 bits (246), Expect = 5e-21
 Identities = 85/307 (27%), Positives = 129/307 (42%), Gaps = 80/307 (26%)

Query: 19  RQVSWITCWIALYAVEALPTCPFSCKC-DSRSLEVDCSGLGLTTVPPDVPAATRTLLLLN 77
           R ++W+  W+  + V A   CP +C C +   +   C   GL  VP  +PAA++ + L  
Sbjct: 10  RLLAWVL-WLQAWQVAA--PCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHG 66

Query: 78  NKLSALPS------------W------------AFANLSSLQRLDLSNN----------- 102
           N++S +P+            W            AF  L+ L++LDLS+N           
Sbjct: 67  NRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATF 126

Query: 103 ---------FLDR-----LPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLS 148
                     LDR     L   +F  L  L  L L++N+++ L  D  R    L HL L 
Sbjct: 127 HGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLH 186

Query: 149 INGLAQLPPGLFDGLLALRSLSLRSNRL---------------------QNLDRLTFE-- 185
            N ++ +P   F GL +L  L L  NR+                      NL  L  E  
Sbjct: 187 GNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEAL 246

Query: 186 -PLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPM 244
            PL  LQ L++ DNPW CDC  R    W++ F    G   ++ C+LP+ L G+D++ +  
Sbjct: 247 APLRALQYLRLNDNPWVCDCRARPLWAWLQKFR---GSSSEVPCSLPQRLAGRDLKRLAA 303

Query: 245 EMFNYCS 251
                C+
Sbjct: 304 NDLQGCA 310


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 79/274 (28%), Positives = 125/274 (45%), Gaps = 11/274 (4%)

Query: 8   PGQRGRLALQWRQVSWITCWIALYAVEALPTCPFSCKCDSRSLEVDCSGLGLTTVPPDVP 67
           PG+R  LAL     +W T  +A+ A +    CP  C C   +  V C  L L  VP   P
Sbjct: 8   PGRRCLLALVLF-CAWGT--LAVVAQKPGAGCPSRCLCFRTT--VRCMHLLLEAVPAVAP 62

Query: 68  AATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNS 127
             T  L L  N++  +   AF  L +L  L L+NN + R+P   F DL NL  L L  N 
Sbjct: 63  Q-TSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNE 121

Query: 128 IRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPL 187
           I+++DR   +    L  L L  N +  L P  F  L  L  L L +NR+ +L   TF  L
Sbjct: 122 IQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHL 181

Query: 188 ANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPMEMF 247
            +++ L++  N   CDC +      ++ ++  G       C  P+ ++G+ +  +  E  
Sbjct: 182 ESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEEL 241

Query: 248 N-----YCSQLEDENSSAGLDIPGPPCTKASPEP 276
           N       S+ +D + ++G  +      + +P+P
Sbjct: 242 NCERPRITSEPQDADVTSGNTVYFTCRAEGNPKP 275


>gi|38202222 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 79/277 (28%), Positives = 129/277 (46%), Gaps = 19/277 (6%)

Query: 59  LTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDR--LPRSIFGDLT 116
           L+T+P  +P     L L +N++S + S +   L+SL+RL L  N L+   L   +F +L 
Sbjct: 166 LSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLV 225

Query: 117 NLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRL 176
           NLTEL L  NS+     +L   +  LR L L  N + ++PP  F  L  L  L + +N L
Sbjct: 226 NLTELSLVRNSLTAAPVNLPGTN--LRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNL 283

Query: 177 QNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRG 236
            NL +  F+ L N+  L + +NPW C C ++  + W++    +   +  L C  P+++RG
Sbjct: 284 SNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVK-VNVRGLMCQAPEKVRG 342

Query: 237 KDMRMVPMEMFNYCSQLEDENSSAGLDIPGPPCTKASPEPAKPKPGAEPEP---EPSTAC 293
             ++ +  E+F+     +D    + + I     T A P    P  G  P P   +P    
Sbjct: 343 MAIKDLNAELFD----CKDSGIVSTIQI-----TTAIPNTVYPAQGQWPAPVTKQPDIKN 393

Query: 294 PQ--KQRHRPASVRRAMGTVIIAGVVCGVVCIMMVVA 328
           P+  K      S  R   T+ +  V    + I   +A
Sbjct: 394 PKLTKDHQTTGSPSRKTITITVKSVTSDTIHISWKLA 430



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 47/146 (32%), Positives = 73/146 (50%), Gaps = 10/146 (6%)

Query: 38  TCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLS--ALPSWAFANLSSLQ 95
           +CP  C+CD+  +   C+   LT++P  +P    TL L NN+++   +PS    NL  ++
Sbjct: 30  SCPSVCRCDAGFIY--CNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPS-DLKNLLKVE 86

Query: 96  RLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLA-- 153
           R+ L +N LD  P ++      + EL L+ N+IRT+  D L   P L  L L  N ++  
Sbjct: 87  RIYLYHNSLDEFPTNL---PKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAV 143

Query: 154 QLPPGLFDGLLALRSLSLRSNRLQNL 179
            +  G F     LR L L  N L  +
Sbjct: 144 SIEEGAFRDSNYLRLLFLSRNHLSTI 169


>gi|7019383 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 79/277 (28%), Positives = 129/277 (46%), Gaps = 19/277 (6%)

Query: 59  LTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDR--LPRSIFGDLT 116
           L+T+P  +P     L L +N++S + S +   L+SL+RL L  N L+   L   +F +L 
Sbjct: 166 LSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLV 225

Query: 117 NLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRL 176
           NLTEL L  NS+     +L   +  LR L L  N + ++PP  F  L  L  L + +N L
Sbjct: 226 NLTELSLVRNSLTAAPVNLPGTN--LRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNL 283

Query: 177 QNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRG 236
            NL +  F+ L N+  L + +NPW C C ++  + W++    +   +  L C  P+++RG
Sbjct: 284 SNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVK-VNVRGLMCQAPEKVRG 342

Query: 237 KDMRMVPMEMFNYCSQLEDENSSAGLDIPGPPCTKASPEPAKPKPGAEPEP---EPSTAC 293
             ++ +  E+F+     +D    + + I     T A P    P  G  P P   +P    
Sbjct: 343 MAIKDLNAELFD----CKDSGIVSTIQI-----TTAIPNTVYPAQGQWPAPVTKQPDIKN 393

Query: 294 PQ--KQRHRPASVRRAMGTVIIAGVVCGVVCIMMVVA 328
           P+  K      S  R   T+ +  V    + I   +A
Sbjct: 394 PKLTKDHQTTGSPSRKTITITVKSVTSDTIHISWKLA 430



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 47/146 (32%), Positives = 73/146 (50%), Gaps = 10/146 (6%)

Query: 38  TCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLS--ALPSWAFANLSSLQ 95
           +CP  C+CD+  +   C+   LT++P  +P    TL L NN+++   +PS    NL  ++
Sbjct: 30  SCPSVCRCDAGFIY--CNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPS-DLKNLLKVE 86

Query: 96  RLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLA-- 153
           R+ L +N LD  P ++      + EL L+ N+IRT+  D L   P L  L L  N ++  
Sbjct: 87  RIYLYHNSLDEFPTNL---PKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAV 143

Query: 154 QLPPGLFDGLLALRSLSLRSNRLQNL 179
            +  G F     LR L L  N L  +
Sbjct: 144 SIEEGAFRDSNYLRLLFLSRNHLSTI 169


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 101/396 (25%), Positives = 143/396 (36%), Gaps = 109/396 (27%)

Query: 35  ALPTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKL----------SALP 84
           A P+CP  C C S    V C     ++VP  +P +T+ L L NN +          + L 
Sbjct: 27  AAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLT 86

Query: 85  SWAFAN------------LSSLQRLDLSNN-------------------------FLDRL 107
            W F+N            L +L+ LDL +N                          L  L
Sbjct: 87  LWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSL 146

Query: 108 PRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALR 167
           P +IF  L +L  L L+ NS+  L  DL      L HL L  N L  L   +F GL +L 
Sbjct: 147 PGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLD 206

Query: 168 SLSLRSNRLQNLDRLTFEPLA------------------------NLQLLQVGDNPWECD 203
            L L  NRLQ + R  F  L+                        +L+ L++  NPW CD
Sbjct: 207 RLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACD 266

Query: 204 CNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYC---------SQLE 254
           C  R    W  WF         + C  P E +G+D+R +    F  C         S+  
Sbjct: 267 CRARPL--W-AWFQRARVSSSDVTCATPPERQGRDLRALREADFQACPPAAPTRPGSRAR 323

Query: 255 DENSSAGL-------DIPGPPCTKASPEPAKPKPGAEPEPEPS----------------T 291
             +SS  L         P  P T     PA+   G +    P+                 
Sbjct: 324 GNSSSNHLYGVAEAGAPPADPSTLYRDLPAEDSRGRQGGDAPTEDDYWGGYGGEDQRGEQ 383

Query: 292 ACPQKQRHRPASVRRAMGTVIIAGVVCGVVCIMMVV 327
            CP      P   R   G  + AG+   ++C++++V
Sbjct: 384 MCPGAACQAPPDSR---GPALSAGLPSPLLCLLLLV 416


>gi|194306623 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 66/219 (30%), Positives = 101/219 (46%), Gaps = 2/219 (0%)

Query: 27  WIALYAVEALPTCPFSCKCDSRSLE--VDCSGLGLTTVPPDVPAATRTLLLLNNKLSALP 84
           W+    +    +CP  C C  +      DC+   L  VP  +PA   TL L  NK++ L 
Sbjct: 8   WLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLR 67

Query: 85  SWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRH 144
             AFA+++ +  L L++N +  +       L+ L  L L +N I +     LR+   L+ 
Sbjct: 68  RGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQL 127

Query: 145 LDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDC 204
           L ++ N L  LP      L  LRSL + +NRL+ L   TF+ L+ L  LQ+  NP+ C C
Sbjct: 128 LKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGC 187

Query: 205 NLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVP 243
            L   + W           D +AC  P  L+G  +  +P
Sbjct: 188 GLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLP 226


>gi|194306621 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 66/219 (30%), Positives = 101/219 (46%), Gaps = 2/219 (0%)

Query: 27  WIALYAVEALPTCPFSCKCDSRSLE--VDCSGLGLTTVPPDVPAATRTLLLLNNKLSALP 84
           W+    +    +CP  C C  +      DC+   L  VP  +PA   TL L  NK++ L 
Sbjct: 8   WLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLR 67

Query: 85  SWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRH 144
             AFA+++ +  L L++N +  +       L+ L  L L +N I +     LR+   L+ 
Sbjct: 68  RGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQL 127

Query: 145 LDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDC 204
           L ++ N L  LP      L  LRSL + +NRL+ L   TF+ L+ L  LQ+  NP+ C C
Sbjct: 128 LKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGC 187

Query: 205 NLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVP 243
            L   + W           D +AC  P  L+G  +  +P
Sbjct: 188 GLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLP 226


>gi|39930401 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 66/219 (30%), Positives = 101/219 (46%), Gaps = 2/219 (0%)

Query: 27  WIALYAVEALPTCPFSCKCDSRSLE--VDCSGLGLTTVPPDVPAATRTLLLLNNKLSALP 84
           W+    +    +CP  C C  +      DC+   L  VP  +PA   TL L  NK++ L 
Sbjct: 8   WLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLR 67

Query: 85  SWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRH 144
             AFA+++ +  L L++N +  +       L+ L  L L +N I +     LR+   L+ 
Sbjct: 68  RGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQL 127

Query: 145 LDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDC 204
           L ++ N L  LP      L  LRSL + +NRL+ L   TF+ L+ L  LQ+  NP+ C C
Sbjct: 128 LKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGC 187

Query: 205 NLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVP 243
            L   + W           D +AC  P  L+G  +  +P
Sbjct: 188 GLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLP 226


>gi|194306618 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 66/219 (30%), Positives = 101/219 (46%), Gaps = 2/219 (0%)

Query: 27  WIALYAVEALPTCPFSCKCDSRSLE--VDCSGLGLTTVPPDVPAATRTLLLLNNKLSALP 84
           W+    +    +CP  C C  +      DC+   L  VP  +PA   TL L  NK++ L 
Sbjct: 8   WLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLR 67

Query: 85  SWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRH 144
             AFA+++ +  L L++N +  +       L+ L  L L +N I +     LR+   L+ 
Sbjct: 68  RGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQL 127

Query: 145 LDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDC 204
           L ++ N L  LP      L  LRSL + +NRL+ L   TF+ L+ L  LQ+  NP+ C C
Sbjct: 128 LKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGC 187

Query: 205 NLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVP 243
            L   + W           D +AC  P  L+G  +  +P
Sbjct: 188 GLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLP 226


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 57/177 (32%), Positives = 86/177 (48%), Gaps = 2/177 (1%)

Query: 22  SWITCWIALYAVEALPTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLS 81
           +W+     L        CP  C C  +  EV CS   L TVP D+P  T+ ++ +    +
Sbjct: 5   AWLLWTSLLLLARPAQPCPMGCDCFVQ--EVFCSDEELATVPLDIPPYTKNIIFVETSFT 62

Query: 82  ALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPL 141
            L + AF +  +L ++   N  L +     FG L  L +L++  +S   L  ++  +   
Sbjct: 63  TLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTS 122

Query: 142 LRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDN 198
           L  L L+ N L  LP GLF  L AL SL L+ N+LQ L R  F+PL +L+ L +  N
Sbjct: 123 LGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQN 179



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 67/213 (31%), Positives = 91/213 (42%), Gaps = 49/213 (23%)

Query: 73  LLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLD 132
           L L +N +S LP   F+ L  L+RL L  N +  LP SIF  L NLT L L+ N +R L 
Sbjct: 222 LFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLP 281

Query: 133 RDLLRHSPLL------------------------RHLDLSINGLAQLPPGLFDGLLALRS 168
             L  H+P L                        R L LS N +  LP G+F  L  L  
Sbjct: 282 AGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVK 341

Query: 169 LSLRSNRLQNLDRLTFEPLANLQLLQVGDN------------------------PWECDC 204
           L L SN L  L    F+ L+ L+LL +  N                        PW+CDC
Sbjct: 342 LYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDC 401

Query: 205 NLREFKHWMEWFSYRGGRLDQLACTLPKELRGK 237
           +L    +W++ ++ R   + Q  C  P  L+G+
Sbjct: 402 HLAYLFNWLQQYTDRLLNI-QTYCAGPAYLKGQ 433



 Score = 75.5 bits (184), Expect = 7e-14
 Identities = 46/128 (35%), Positives = 69/128 (53%)

Query: 68  AATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNS 127
           AA  +L L  N+L ALP   F  L+ L+ L+L+ N L +LP  +F  LT+L  L+L NN+
Sbjct: 145 AALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNA 204

Query: 128 IRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPL 187
           +  L + +      L+ L L  N +++LPP +F  L  L  L L+ N + +L    F  L
Sbjct: 205 LSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASL 264

Query: 188 ANLQLLQV 195
            NL  L +
Sbjct: 265 GNLTFLSL 272



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 49/126 (38%), Positives = 65/126 (51%), Gaps = 1/126 (0%)

Query: 74  LLLN-NKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLD 132
           L LN N L ALP   F +L++L+ L L  N L  LPR +F  LT+L  L L  N +  L 
Sbjct: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185

Query: 133 RDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQL 192
            +L      L+ L LS N L+ LP G+F  L +L+ L L SN +  L    F  L  L+ 
Sbjct: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245

Query: 193 LQVGDN 198
           L +  N
Sbjct: 246 LWLQRN 251


>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
           sapiens]
          Length = 674

 Score = 92.4 bits (228), Expect = 6e-19
 Identities = 65/194 (33%), Positives = 97/194 (50%), Gaps = 13/194 (6%)

Query: 59  LTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFL--DRLPRSIFGDLT 116
           L+++P  +P     L L +N++S +P  AF  L+SL+RL L  N L   R+    F  L 
Sbjct: 189 LSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQ 248

Query: 117 NLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRL 176
           NLTEL L  NS+     +L   S  L+ L L  N ++ +P      +  L  L L +N L
Sbjct: 249 NLTELSLVRNSLAAPPLNL--PSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNL 306

Query: 177 QNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWME----WFSYRGGRLDQLACTLPK 232
             L R  F+ L NL  L + +NPW C CNL   + W++      + RG     L C  P+
Sbjct: 307 TTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAAVVNVRG-----LMCQGPE 361

Query: 233 ELRGKDMRMVPMEM 246
           ++RG  ++ +  EM
Sbjct: 362 KVRGMAIKDITSEM 375



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 37/189 (19%)

Query: 38  TCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLS--ALPSWAFANLSSLQ 95
           TCP  C+CD+  +   C+  GLT++P D+P    TL L NN+++   +P      ++ +Q
Sbjct: 53  TCPSVCRCDNGFIY--CNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVN-VQ 109

Query: 96  RLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLR--HLD------- 146
            + L  N LD  P ++     +L EL L++N++RT+ RD L   PLL   HLD       
Sbjct: 110 VIYLYENDLDEFPINL---PRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTV 166

Query: 147 -----------------LSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLAN 189
                            LS N L+ +P GL      L  L L  NR+  +    F+ L +
Sbjct: 167 SIEEDAFADSKQLKLLFLSRNHLSSIPSGLPH---TLEELRLDDNRISTIPLHAFKGLNS 223

Query: 190 LQLLQVGDN 198
           L+ L +  N
Sbjct: 224 LRRLVLDGN 232


>gi|59823631 G protein-coupled receptor 125 [Homo sapiens]
          Length = 1321

 Score = 92.0 bits (227), Expect = 7e-19
 Identities = 75/229 (32%), Positives = 101/229 (44%), Gaps = 42/229 (18%)

Query: 40  PFSCKCDSRSL-----------EVDCSGLGLTTV-PPD-VPAATRTLLLLNNKLSALPSW 86
           P  CK D R             +V CS L L  V PPD +P  T TL+L NNK+S L + 
Sbjct: 40  PAGCKHDGRPRGAGRAAGAAEGKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNG 99

Query: 87  AFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLD 146
           +F+ LS L+RLDL NN +  +    F  L++L  L L NN I  L+ D+ R    L  L+
Sbjct: 100 SFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLN 159

Query: 147 LSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNL 206
           LS N  + L  G FD L +LRSL  ++  L                         CDCN+
Sbjct: 160 LSGNLFSSLSQGTFDYLASLRSLEFQTEYLL------------------------CDCNI 195

Query: 207 REFKHWM-EWFSYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQLE 254
                WM  W   +   +    C  PK L+ + +  V  E+      LE
Sbjct: 196 L----WMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLE 240


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score = 92.0 bits (227), Expect = 7e-19
 Identities = 58/160 (36%), Positives = 80/160 (50%), Gaps = 4/160 (2%)

Query: 35  ALPTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSL 94
           A P C   C CD     VDCSG GLT VP  + A T+ L +  N ++ LP  AF N   L
Sbjct: 25  APPLCAAPCSCDG-DRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFL 83

Query: 95  QRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQ 154
           + L L+ N L  +       L  L  L L+NN ++T+  + +R    L+ L L  N +  
Sbjct: 84  EELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITS 143

Query: 155 LPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQ 194
           +P   F+GL+ LR L L  N   +L  +   PL+NL  LQ
Sbjct: 144 VPEDSFEGLVQLRHLWLDDN---SLTEVPVHPLSNLPTLQ 180



 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 68/231 (29%), Positives = 106/231 (45%), Gaps = 10/231 (4%)

Query: 33  VEALPTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAAT-RTLLLLNNKLSALPSWAFANL 91
           + ++P   F      R L +D + L    V P     T + L L  NK+S++P +AF NL
Sbjct: 141 ITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNL 200

Query: 92  SSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSING 151
           SSL  L L NN +  L +  F  L NL  L L  N++    +  ++  P L+ L    N 
Sbjct: 201 SSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ-AIKALPSLKELGFHSNS 259

Query: 152 LAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQV-GDNPWECDCNLREFK 210
           ++ +P G FDG   LR++ L  N L  +    F  L++L  L + G +  +   NL    
Sbjct: 260 ISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTV 319

Query: 211 HWMEWFSYRGGRLDQL---ACTLPKELRGKDM---RMVPMEMFNYCSQLED 255
           H +E  +  G ++  +    C   K LR  D+    +  +  FN C  LE+
Sbjct: 320 H-LESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEE 369



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 48/155 (30%), Positives = 77/155 (49%), Gaps = 6/155 (3%)

Query: 48  RSLEVDCSGLGLTTVPPDV---PAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFL 104
           +SL +D + +  T+VP D        R L L +N L+ +P    +NL +LQ L L+ N +
Sbjct: 132 QSLRLDANHI--TSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKI 189

Query: 105 DRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLL 164
             +P   F +L++L  L L NN IR+L +        L  LDL+ N L + P  +   L 
Sbjct: 190 SSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAI-KALP 248

Query: 165 ALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNP 199
           +L+ L   SN +  +    F+    L+ + + DNP
Sbjct: 249 SLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNP 283



 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 42/150 (28%), Positives = 64/150 (42%), Gaps = 23/150 (15%)

Query: 71  RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRT 130
           RT+ L +N LS + + AF NLS L  L +    + +   ++ G + +L  L L    I +
Sbjct: 275 RTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTV-HLESLTLTGTKISS 333

Query: 131 LDRDLLRHSPLLRHLDLSINGLAQLPP----------------------GLFDGLLALRS 168
           +  +L +   +LR LDLS N +  LP                       G F GL++LR 
Sbjct: 334 IPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRI 393

Query: 169 LSLRSNRLQNLDRLTFEPLANLQLLQVGDN 198
           L L  N +  +    F  L  +  L V  N
Sbjct: 394 LDLSRNLIHEIHSRAFATLGPITNLDVSFN 423



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 38/134 (28%), Positives = 56/134 (41%), Gaps = 9/134 (6%)

Query: 71  RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRT 130
           RTL L  N +  LPS  F    +L+ + L  N + ++    F  L +L  L L  N I  
Sbjct: 346 RTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHE 403

Query: 131 LDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANL 190
           +          + +LD+S N L   P    +GL  L  L L  N  +  + L  +   NL
Sbjct: 404 IHSRAFATLGPITNLDVSFNELTSFPT---EGLNGLNQLKLVGN-FKLKEALAAKDFVNL 459

Query: 191 QLLQVGDNPWECDC 204
           + L V   P+   C
Sbjct: 460 RSLSV---PYAYQC 470


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,351,409
Number of Sequences: 37866
Number of extensions: 815646
Number of successful extensions: 9203
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 243
Number of HSP's successfully gapped in prelim test: 155
Number of HSP's that attempted gapping in prelim test: 6891
Number of HSP's gapped (non-prelim): 1356
length of query: 370
length of database: 18,247,518
effective HSP length: 104
effective length of query: 266
effective length of database: 14,309,454
effective search space: 3806314764
effective search space used: 3806314764
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.