Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 84626578
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|84626578 G protein beta subunit-like [Homo sapiens]
(326 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|84626578 G protein beta subunit-like [Homo sapiens] 686 0.0
gi|32189425 WD repeat domain 69 [Homo sapiens] 85 1e-16
gi|16554629 WD repeat domain 5 [Homo sapiens] 81 1e-15
gi|16554627 WD repeat domain 5 [Homo sapiens] 81 1e-15
gi|23199987 WD repeat domain 5B [Homo sapiens] 76 5e-14
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 75 6e-14
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 75 6e-14
gi|113865883 WD repeat domain 38 [Homo sapiens] 75 8e-14
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 75 1e-13
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 74 2e-13
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 73 4e-13
gi|21071067 TBP-associated factor 5 [Homo sapiens] 71 1e-12
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 71 1e-12
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ... 70 3e-12
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 67 2e-11
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 67 2e-11
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 67 3e-11
gi|18874090 WD repeat domain 48 [Homo sapiens] 66 4e-11
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 64 2e-10
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 64 2e-10
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 64 2e-10
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 64 2e-10
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 64 2e-10
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 64 2e-10
gi|26665869 WD repeat domain 51B [Homo sapiens] 62 5e-10
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 62 7e-10
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 62 7e-10
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 62 7e-10
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 62 7e-10
gi|19913367 transducin beta-like 1Y [Homo sapiens] 62 9e-10
>gi|84626578 G protein beta subunit-like [Homo sapiens]
Length = 326
Score = 686 bits (1769), Expect = 0.0
Identities = 326/326 (100%), Positives = 326/326 (100%)
Query: 1 MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA 60
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA
Sbjct: 1 MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA 60
Query: 61 GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 120
GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ
Sbjct: 61 GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 120
Query: 121 CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 180
CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP
Sbjct: 121 CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 180
Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 240
DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
Sbjct: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 240
Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE
Sbjct: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300
Query: 301 TGEIKREYGGHQKAVVCLAFNDSVLG 326
TGEIKREYGGHQKAVVCLAFNDSVLG
Sbjct: 301 TGEIKREYGGHQKAVVCLAFNDSVLG 326
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 84.7 bits (208), Expect = 1e-16
Identities = 70/307 (22%), Positives = 127/307 (41%), Gaps = 21/307 (6%)
Query: 17 TAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVT-PDRSMIAAAGYQHI-RMYDLNSNN 74
T YD T + W SG T++ + V A+ P IA + +++ + +
Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK 168
Query: 75 PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCV 134
++ G I + F+ + TG D TA++WD+++ + + +A I +
Sbjct: 169 CYH--TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGE-EVYTLRGHSAEIISL 225
Query: 135 CLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNC 194
+ + +I G + +WD T ++ I+SA + D S + + C
Sbjct: 226 SFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285
Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSL 254
+W+ T G + H L F L+AT SAD T +I+ +
Sbjct: 286 KLWDATNGKC--------VATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC 337
Query: 255 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKA 314
+ +L G+ GE S+ +F+ +++T SSD AR+W +TG+ + GH
Sbjct: 338 IAKLE---GHEGEISK-----ISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDE 389
Query: 315 VVCLAFN 321
+ AFN
Sbjct: 390 IFSCAFN 396
Score = 58.5 bits (140), Expect = 8e-09
Identities = 53/281 (18%), Positives = 102/281 (36%), Gaps = 62/281 (22%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI-RMYDLNSN 73
+AT +D T + W +G C T + +++ L P +++A +++D+
Sbjct: 150 IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ-- 207
Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL---RSRNLQCQRIFQVN-A 129
N + + G + I S+ F+ G + TG D T +WD R N+ +++ A
Sbjct: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA 267
Query: 130 PINCVCLHPNQAELIVGDQSGAIHIWDLK--------TDHNEQLIPE------------- 168
N C + ++ G +WD T H+++++
Sbjct: 268 SFNWDC-----SLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATAS 322
Query: 169 ---------------------PEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207
E I+ +P +++ +S +W+ G +V
Sbjct: 323 ADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248
+ HT C F+ ++ T S D TC+IWR
Sbjct: 383 LE--------GHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 53.9 bits (128), Expect = 2e-07
Identities = 32/107 (29%), Positives = 48/107 (44%), Gaps = 9/107 (8%)
Query: 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275
+ AH + + T S D+TCK+W T++ + L E R ++
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTL--------EGHRNVVYA 139
Query: 276 CAFSGD-SQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
AF+ I T S D +LW VETG+ + GH +VCL+FN
Sbjct: 140 IAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFN 186
Score = 51.2 bits (121), Expect = 1e-06
Identities = 43/165 (26%), Positives = 71/165 (43%), Gaps = 35/165 (21%)
Query: 173 ITSAHIDPDASYMAAVNSTGNCYV----------WNLTGGIGDEVTQLIPKTKIPAHTRY 222
+ AHI P + A+N +G+C++ W+ G +E+ L H
Sbjct: 87 VLKAHILPLTN--VALNKSGSCFITGSYDRTCKLWDTASG--EELNTL------EGHRNV 136
Query: 223 ALQCRFS-PDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGW---MWGCAF 278
F+ P +AT S D+TCK+W S+++G + RG + +F
Sbjct: 137 VYAIAFNNPYGDKIATGSFDKTCKLW-----------SVETGKCYHTFRGHTAEIVCLSF 185
Query: 279 SGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323
+ S + T S D A+LW ++ GE GH ++ L+FN S
Sbjct: 186 NPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTS 230
Score = 48.1 bits (113), Expect = 1e-05
Identities = 33/146 (22%), Positives = 59/146 (40%), Gaps = 4/146 (2%)
Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 70
D ++ T D T + W A +G C T+ D ++ +IA A
Sbjct: 272 DCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARI-F 330
Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP 130
++ I +G I+ + F+ G + TG D TARIWD ++ QC ++ + +
Sbjct: 331 SAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTG--QCLQVLEGHTD 388
Query: 131 INCVCLHPNQAELIV-GDQSGAIHIW 155
C + +++ G + IW
Sbjct: 389 EIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 80.9 bits (198), Expect = 1e-15
Identities = 69/289 (23%), Positives = 129/289 (44%), Gaps = 26/289 (8%)
Query: 37 TVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHE 95
T+ V++++ +P+ +A++ I+++ IS G I+ V +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS--GHKLGISDVAWSS 97
Query: 96 DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIV-GDQSGAIHI 154
D + + +D T +IWD+ S +C + + ++ C Q+ LIV G ++ I
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 155 WDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKT 214
WD+KT + +P +++ H + D S + + + G C +W+ G Q + KT
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG------QCL-KT 208
Query: 215 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMW 274
I +FSP+ + + D T K+W ++S L +G+ E
Sbjct: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW---DYSKGKCLKTYTGHKNEKY----- 260
Query: 275 GCAFSGDS----QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319
C F+ S ++IV+ S DNL +W ++T EI ++ GH V+ A
Sbjct: 261 -CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308
Score = 73.6 bits (179), Expect = 2e-13
Identities = 57/244 (23%), Positives = 104/244 (42%), Gaps = 16/244 (6%)
Query: 83 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAE 142
G K ++SV F +G W+ + D +IW + + I I+ V +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNL 101
Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202
L+ + IWD+ + + + + + +P ++ + + + + +W++ G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS 262
KT +PAH+ F+ D +L+ + S D C+IW T++ + L I
Sbjct: 162 -------KCLKT-LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL-IDD 212
Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322
NP S FS + +YI+ A+ DN +LW G+ + Y GH+ C+ N
Sbjct: 213 DNPPVSF------VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 323 SVLG 326
SV G
Sbjct: 267 SVTG 270
Score = 71.6 bits (174), Expect = 9e-13
Identities = 56/252 (22%), Positives = 107/252 (42%), Gaps = 28/252 (11%)
Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMY 68
SD +L +A D T++ W SG C +T++ + V P ++I + + + +R++
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128
D+ + + + + +++V F+ DG + + D RIWD S I N
Sbjct: 157 DVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 129 APINCVCLHPNQAELIVGDQSGAIHIWD------LKT---DHNEQLIPEPEVSITSAHID 179
P++ V PN ++ + +WD LKT NE+ S+T
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG---- 270
Query: 180 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239
++ + + Y+WNL E+ Q K+ HT + P ++A+ +
Sbjct: 271 --GKWIVSGSEDNLVYIWNLQ---TKEIVQ-----KLQGHTDVVISTACHPTENIIASAA 320
Query: 240 A--DQTCKIWRT 249
D+T K+W++
Sbjct: 321 LENDKTIKLWKS 332
Score = 57.4 bits (137), Expect = 2e-08
Identities = 35/109 (32%), Positives = 50/109 (45%), Gaps = 8/109 (7%)
Query: 213 KTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGW 272
K + HT+ +FSP+ LA+ SAD+ KIW + E +I G S W
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFEKTISGHKLGISDVAW 95
Query: 273 MWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
S DS +V+AS D ++W V +G+ + GH V C FN
Sbjct: 96 ------SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN 138
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 80.9 bits (198), Expect = 1e-15
Identities = 69/289 (23%), Positives = 129/289 (44%), Gaps = 26/289 (8%)
Query: 37 TVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHE 95
T+ V++++ +P+ +A++ I+++ IS G I+ V +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS--GHKLGISDVAWSS 97
Query: 96 DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIV-GDQSGAIHI 154
D + + +D T +IWD+ S +C + + ++ C Q+ LIV G ++ I
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 155 WDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKT 214
WD+KT + +P +++ H + D S + + + G C +W+ G Q + KT
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG------QCL-KT 208
Query: 215 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMW 274
I +FSP+ + + D T K+W ++S L +G+ E
Sbjct: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW---DYSKGKCLKTYTGHKNEKY----- 260
Query: 275 GCAFSGDS----QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319
C F+ S ++IV+ S DNL +W ++T EI ++ GH V+ A
Sbjct: 261 -CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308
Score = 73.6 bits (179), Expect = 2e-13
Identities = 57/244 (23%), Positives = 104/244 (42%), Gaps = 16/244 (6%)
Query: 83 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAE 142
G K ++SV F +G W+ + D +IW + + I I+ V +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNL 101
Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202
L+ + IWD+ + + + + + +P ++ + + + + +W++ G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS 262
KT +PAH+ F+ D +L+ + S D C+IW T++ + L I
Sbjct: 162 -------KCLKT-LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL-IDD 212
Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322
NP S FS + +YI+ A+ DN +LW G+ + Y GH+ C+ N
Sbjct: 213 DNPPVSF------VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 323 SVLG 326
SV G
Sbjct: 267 SVTG 270
Score = 71.6 bits (174), Expect = 9e-13
Identities = 56/252 (22%), Positives = 107/252 (42%), Gaps = 28/252 (11%)
Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMY 68
SD +L +A D T++ W SG C +T++ + V P ++I + + + +R++
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128
D+ + + + + +++V F+ DG + + D RIWD S I N
Sbjct: 157 DVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 129 APINCVCLHPNQAELIVGDQSGAIHIWD------LKT---DHNEQLIPEPEVSITSAHID 179
P++ V PN ++ + +WD LKT NE+ S+T
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG---- 270
Query: 180 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239
++ + + Y+WNL E+ Q K+ HT + P ++A+ +
Sbjct: 271 --GKWIVSGSEDNLVYIWNLQ---TKEIVQ-----KLQGHTDVVISTACHPTENIIASAA 320
Query: 240 A--DQTCKIWRT 249
D+T K+W++
Sbjct: 321 LENDKTIKLWKS 332
Score = 57.4 bits (137), Expect = 2e-08
Identities = 35/109 (32%), Positives = 50/109 (45%), Gaps = 8/109 (7%)
Query: 213 KTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGW 272
K + HT+ +FSP+ LA+ SAD+ KIW + E +I G S W
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFEKTISGHKLGISDVAW 95
Query: 273 MWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
S DS +V+AS D ++W V +G+ + GH V C FN
Sbjct: 96 ------SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN 138
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 75.9 bits (185), Expect = 5e-14
Identities = 58/242 (23%), Positives = 109/242 (45%), Gaps = 23/242 (9%)
Query: 83 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP-INCVCLHPNQA 141
G N I+ V + D + + +D T ++WD+RS +C + + ++ + C +P
Sbjct: 81 GHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG--KCLKTLKGHSNYVFCCNFNPPSN 138
Query: 142 ELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTG 201
+I G + IW++KT + + +++ H + S + + + G C +W+
Sbjct: 139 LIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAAS 198
Query: 202 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 261
G Q + KT + +FSP+ + T + D T K+W ++S L
Sbjct: 199 G------QCL-KTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLW---DYSRGRCLKTY 248
Query: 262 SGNPGESSRGWMWGCAFSGDS----QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVC 317
+G+ E C F+ S ++IV+ S DNL +W ++T EI ++ GH V+
Sbjct: 249 TGHKNEKY------CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 302
Query: 318 LA 319
A
Sbjct: 303 AA 304
Score = 67.4 bits (163), Expect = 2e-11
Identities = 55/255 (21%), Positives = 106/255 (41%), Gaps = 18/255 (7%)
Query: 74 NPNPIISYD--GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131
NPN + G + ++SV F +G W+ + D IW + + ++ N I
Sbjct: 28 NPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE-KTLYGHNLEI 86
Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191
+ V + + L+ + +WD+++ + + + + +P ++ + + +
Sbjct: 87 SDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251
+W + G KT + AH+ F+ +L+ + S D C+IW ++
Sbjct: 147 ETVKIWEVKTG-------KCLKT-LSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAAS 198
Query: 252 FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGH 311
+ L + NP S FS + +YI+TA+ DN +LW G + Y GH
Sbjct: 199 GQCLKTL-VDDDNPPVSF------VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGH 251
Query: 312 QKAVVCLAFNDSVLG 326
+ C+ N SV G
Sbjct: 252 KNEKYCIFANFSVTG 266
Score = 66.6 bits (161), Expect = 3e-11
Identities = 55/254 (21%), Positives = 107/254 (42%), Gaps = 28/254 (11%)
Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMY 68
SD L +A D T++ W SG C +T++ + V P ++I + + + ++++
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128
++ + +S + +++V F+ G + +G D RIWD S + N
Sbjct: 153 EVKTGKCLKTLS--AHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDN 210
Query: 129 APINCVCLHPNQAELIVGDQSGAIHIWD------LKT---DHNEQLIPEPEVSITSAHID 179
P++ V PN ++ + +WD LKT NE+ S+T
Sbjct: 211 PPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG---- 266
Query: 180 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239
++ + + Y+WNL E+ Q K+ HT + P L+A+ +
Sbjct: 267 --GKWIVSGSEDNLVYIWNLQ---TKEIVQ-----KLQGHTDVVISAACHPTENLIASAA 316
Query: 240 A--DQTCKIWRTSN 251
D+T K+W +++
Sbjct: 317 LENDKTIKLWMSNH 330
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 75.5 bits (184), Expect = 6e-14
Identities = 54/225 (24%), Positives = 98/225 (43%), Gaps = 17/225 (7%)
Query: 97 GRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWD 156
GR + TGG+DC +W + N + +P+ V L+ + ++ G QSG+I +WD
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNC-IMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
Query: 157 LKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKI 216
L+ + + + +I S P ++A+ + N +W ++ + +
Sbjct: 92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW--------DIRRKGCVFRY 143
Query: 217 PAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGC 276
H++ RFSPD LA+ + D T K+W + +M+E PG + G +
Sbjct: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF------PGHT--GPVNVV 195
Query: 277 AFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
F + + + SSD R W +E ++ G V + FN
Sbjct: 196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFN 240
Score = 66.2 bits (160), Expect = 4e-11
Identities = 52/224 (23%), Positives = 90/224 (40%), Gaps = 12/224 (5%)
Query: 43 SQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT 102
S V++L + + A G R+ + N PN I+S G + SV + +
Sbjct: 21 SNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVA 80
Query: 103 GGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHN 162
G + + R+WDL + + + + A I + HP + G Q I +WD++
Sbjct: 81 GSQSGSIRVWDLEAAKI-LRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGC 139
Query: 163 EQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRY 222
++ PD ++A+ +W+LT G ++ P HT
Sbjct: 140 VFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG--------KMMSEFPGHTGP 191
Query: 223 ALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPG 266
F P+ LLA+ S+D+T + W F + +S G PG
Sbjct: 192 VNVVEFHPNEYLLASGSSDRTIRFWDLEKFQV---VSCIEGEPG 232
Score = 61.6 bits (148), Expect = 9e-10
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 4/169 (2%)
Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNS 72
++ ++R W + RT+ + + +L+ P +A+ +I+++D+
Sbjct: 77 LIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRR 136
Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 132
+ Y G ++ + + F DG+W+ + +D T ++WDL + + + P+N
Sbjct: 137 KGC--VFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSE-FPGHTGPVN 193
Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD 181
V HPN+ L G I WDL+ I + S +PD
Sbjct: 194 VVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPD 242
Score = 60.1 bits (144), Expect = 3e-09
Identities = 42/187 (22%), Positives = 79/187 (42%), Gaps = 4/187 (2%)
Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEV-TPDRSMIAAAGYQHIRMYDLNS 72
+LAT G D V W + C ++ S V ++ + TP+ ++A + IR++DL +
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 132
+ + G NI S+ FH G ++ +G +D ++WD+R + R + +
Sbjct: 95 --AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGC-VFRYRGHSQAVR 151
Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTG 192
C+ P+ L + +WDL P + P+ +A+ +S
Sbjct: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDR 211
Query: 193 NCYVWNL 199
W+L
Sbjct: 212 TIRFWDL 218
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 75.5 bits (184), Expect = 6e-14
Identities = 50/214 (23%), Positives = 90/214 (42%), Gaps = 14/214 (6%)
Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAI 152
F +D + TG + +IWD+ + L + + L+ + +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 153 HIWDLKTDHNEQLIPEPEVS-ITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211
+WDLK D N + + + S PD+S + +V ++ ++WN+ D+ T +
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM-----DKYTMI- 249
Query: 212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNP-----G 266
K+ H + C FSPD LLAT S D IW N ++ E P G
Sbjct: 250 --RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAG 307
Query: 267 ESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300
++ W+ +FS D ++ + + D + R W ++
Sbjct: 308 GANDRWVRSVSFSHDGLHVASLADDKMVRFWRID 341
Score = 55.1 bits (131), Expect = 8e-08
Identities = 41/172 (23%), Positives = 70/172 (40%), Gaps = 16/172 (9%)
Query: 139 NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY-MAAVNSTGNCYVW 197
+Q L G +G I IWD+ T + + + PD S + + + VW
Sbjct: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
Query: 198 NLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTE 257
+L D+ + + H + C FSPDS++L + A + +W ++++ +
Sbjct: 199 DLK----DDGNMM---KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRK 251
Query: 258 LSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 309
L E + C FS D + TAS D +W G+I E+G
Sbjct: 252 L--------EGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFG 295
Score = 47.4 bits (111), Expect = 2e-05
Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 8/104 (7%)
Query: 219 HTRYALQCRFSPDSTL-LATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277
HT F+PD +L L + S D+T ++W + M ++ + W++ CA
Sbjct: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVL-------RGHQNWVYSCA 221
Query: 278 FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
FS DS + + + LW ++ + R+ GH VV F+
Sbjct: 222 FSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFS 265
Score = 44.3 bits (103), Expect = 1e-04
Identities = 53/294 (18%), Positives = 96/294 (32%), Gaps = 57/294 (19%)
Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY 68
G D ++LAT + ++ W ++G + V L PD S+I
Sbjct: 137 GQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLI----------- 185
Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128
+ + D T R+WDL+ + +
Sbjct: 186 -------------------------------LVSASRDKTLRVWDLKDDGNMMKVLRGHQ 214
Query: 129 APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAV 188
+ P+ + L S A+ +W++ + + + + PD + +A
Sbjct: 215 NWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATA 274
Query: 189 NSTGNCYVWN-LTGGIGDEVTQLI-PKTKI---PAHTRYALQCRFSPDSTLLATCSADQT 243
+ Y+W+ G I E L P T I A+ R+ FS D +A+ + D+
Sbjct: 275 SYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKM 334
Query: 244 CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297
+ WR + + +G CAFS D + + D W
Sbjct: 335 VRFWRIDEDYPVQVAPLSNG----------LCCAFSTDGSVLAAGTHDGSVYFW 378
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 75.1 bits (183), Expect = 8e-14
Identities = 65/244 (26%), Positives = 105/244 (43%), Gaps = 15/244 (6%)
Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMYD 69
D + A+A D TVR W C R ++ V + +PD +A+ G+ + + ++D
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 70 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLR--SRNLQCQRIFQV 127
+ S ++ G +I S F + TG D T IWDLR + + Q +
Sbjct: 134 VQSGQMLRLLV--GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH 191
Query: 128 NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAA 187
+A I+C+C + L G IHIW T + + S PD ++A+
Sbjct: 192 SANISCLC-YSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCK-I 246
+ VW+ G + + + AHT C F+PD +L + +ADQT + I
Sbjct: 251 AGYSRMVKVWDCNTG---KCLETLKGVLDVAHT-----CAFTPDGKILVSGAADQTRRQI 302
Query: 247 WRTS 250
RTS
Sbjct: 303 SRTS 306
Score = 74.7 bits (182), Expect = 1e-13
Identities = 62/281 (22%), Positives = 117/281 (41%), Gaps = 29/281 (10%)
Query: 24 VRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDG 83
V+F+ H G +VN+ +PD M+ G + +Y + + + G
Sbjct: 14 VKFFGQHGG-----------EVNSSAFSPDGQMLLT-GSEDGCVYGWETRSGQLLWRLGG 61
Query: 84 VNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA-PINCVCLHPNQAE 142
+ F DG + DCT R+WD+ +C R+ + + + V P+ +
Sbjct: 62 HTGPVKFCRFSPDGHLFASASCDCTVRLWDVA--RAKCLRVLKGHQRSVETVSFSPDSRQ 119
Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202
L G + +WD+++ +L+ SI S+ P + +A + ++W+L
Sbjct: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR-- 177
Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS 262
VT + + H+ + C S LLA+ S D+T IW+ + SL+ +L
Sbjct: 178 ---MVTPAVSHQALEGHSAN-ISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQL---- 229
Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGE 303
+ W+ AFS D ++ +A + ++W TG+
Sbjct: 230 ----KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGK 266
Score = 58.9 bits (141), Expect = 6e-09
Identities = 64/301 (21%), Positives = 112/301 (37%), Gaps = 48/301 (15%)
Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYD 69
D +L T D V W+ SG + V +PD + A+A +R++D
Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Query: 70 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 129
+ ++ G +++ +V F D R + +GG D +WD++S + + +
Sbjct: 92 VARAKCLRVLK--GHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM-LRLLVGHRD 148
Query: 130 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 189
I P L G +HIWDL+ + P S+ A
Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLRM------------------VTPAVSHQALEG 190
Query: 190 STGN----CYVWN--LTGGIGDEVTQLIPKT------KIPAHTRYALQCRFSPDSTLLAT 237
+ N CY + L G D+ + T ++ H + FSPD LA+
Sbjct: 191 HSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
Query: 238 CSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM---WGCAFSGDSQYIVTASSDNLA 294
+ K+W +G E+ +G + CAF+ D + +V+ ++D
Sbjct: 251 AGYSRMVKVW-----------DCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTR 299
Query: 295 R 295
R
Sbjct: 300 R 300
Score = 54.7 bits (130), Expect = 1e-07
Identities = 38/152 (25%), Positives = 66/152 (43%), Gaps = 16/152 (10%)
Query: 173 ITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS 232
+ S+ PD + + G Y W G QL+ ++ HT CRFSPD
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSG------QLL--WRLGGHTGPVKFCRFSPDG 75
Query: 233 TLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDN 292
L A+ S D T ++W + + L + + + +FS DS+ + + D
Sbjct: 76 HLFASASCDCTVRLWDVARAKCLRVL--------KGHQRSVETVSFSPDSRQLASGGWDK 127
Query: 293 LARLWCVETGEIKREYGGHQKAVVCLAFNDSV 324
LW V++G++ R GH+ ++ F+ +V
Sbjct: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTV 159
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 74.7 bits (182), Expect = 1e-13
Identities = 68/299 (22%), Positives = 117/299 (39%), Gaps = 33/299 (11%)
Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP---------DRSMIAAAGYQH 64
+LATA + + W T++ ++ V A+ P D ++ + A
Sbjct: 245 MLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGS 304
Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124
++++ L+S+ P + +G +A V +H GR++ T D + R+WDL ++ + +
Sbjct: 305 VKLWSLDSDEP--VADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE---EIL 359
Query: 125 FQVNAPINC--VCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDA 182
Q + + H + + G +WDL+T + I + P+
Sbjct: 360 HQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNG 419
Query: 183 SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSAD 241
++A + C VW+L Q IPAH +F P L T + D
Sbjct: 420 YHIATGSGDNTCKVWDLR--------QRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYD 471
Query: 242 QTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300
T KIW +S + L+ G + G S D Q I T S D +LW E
Sbjct: 472 NTAKIWTHPGWSPLKTLA--------GHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
Score = 73.9 bits (180), Expect = 2e-13
Identities = 59/246 (23%), Positives = 97/246 (39%), Gaps = 17/246 (6%)
Query: 7 TVGSDP--VILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH 64
TV DP V LA+ D +V+ W S ++ +V + P + Y
Sbjct: 286 TVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDR 345
Query: 65 I-RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR 123
R++DL + I+ +G + + + FH+DG TGG D R+WDLR+ +C
Sbjct: 346 SWRLWDLEAQEE--ILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTG--RCIM 401
Query: 124 IFQVN-APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-D 181
+ + I + PN + G +WDL+ IP + +T +P
Sbjct: 402 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 461
Query: 182 ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSAD 241
+++ +W G P + H + S D L+ATCS D
Sbjct: 462 GNFLLTGAYDNTAKIWTHPG--------WSPLKTLAGHEGKVMGLDISSDGQLIATCSYD 513
Query: 242 QTCKIW 247
+T K+W
Sbjct: 514 RTFKLW 519
Score = 45.8 bits (107), Expect = 5e-05
Identities = 51/219 (23%), Positives = 86/219 (39%), Gaps = 31/219 (14%)
Query: 114 LRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKT--------DHNEQ- 164
LRS N C +I + PI+ PN L SG +W + HN
Sbjct: 218 LRSLNNFCSQIGD-DRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNV 276
Query: 165 --LIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRY 222
++ P+ +++ +DP +A+ + G+ +W+L DE P I HT
Sbjct: 277 GAIVFHPKSTVS---LDPKDVNLASCAADGSVKLWSLDS---DE-----PVADIEGHTVR 325
Query: 223 ALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDS 282
+ + P L T D++ ++W + E+ + G+ S G ++ AF D
Sbjct: 326 VARVMWHPSGRFLGTTCYDRSWRLW---DLEAQEEILHQEGH----SMG-VYDIAFHQDG 377
Query: 283 QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
T D R+W + TG GH K + + F+
Sbjct: 378 SLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFS 416
Score = 42.0 bits (97), Expect = 7e-04
Identities = 50/254 (19%), Positives = 86/254 (33%), Gaps = 27/254 (10%)
Query: 76 NPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL-QCQRIFQVNA----- 129
N S G ++ I+ F + + + T ++W + NL R N
Sbjct: 222 NNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVF 281
Query: 130 -PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAV 188
P + V L P L G++ +W L +D I V + P ++
Sbjct: 282 HPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTT 341
Query: 189 NSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW- 247
+ +W+L +E+ H+ F D +L T D ++W
Sbjct: 342 CYDRSWRLWDLEAQ--EEILHQ------EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWD 393
Query: 248 -RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKR 306
RT + E +K ++G FS + +I T S DN ++W +
Sbjct: 394 LRTGRCIMFLEGHLKE----------IYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVY 443
Query: 307 EYGGHQKAVVCLAF 320
HQ V + F
Sbjct: 444 TIPAHQNLVTGVKF 457
Score = 38.5 bits (88), Expect = 0.008
Identities = 23/98 (23%), Positives = 43/98 (43%)
Query: 226 CRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYI 285
C FSP+S +LAT CK+W + +L+ L + N G + +
Sbjct: 237 CHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNL 296
Query: 286 VTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323
+ ++D +LW +++ E + GH V + ++ S
Sbjct: 297 ASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPS 334
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 73.9 bits (180), Expect = 2e-13
Identities = 70/295 (23%), Positives = 120/295 (40%), Gaps = 19/295 (6%)
Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQD-SQVNALEVTPDRSMIAAAGYQH-IRMY 68
D L + YD TV+ W G R +H+ + V +T D S + AA Y +R +
Sbjct: 113 DDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAW 172
Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128
DL + + YD I S F DG+++ +G D I + + N+ + + +
Sbjct: 173 DLETGKLLWKVRYDTF---IVSCKFSPDGKYVVSGF-DVDHGICIMDAENITTVSVIKDH 228
Query: 129 --APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVS-ITSAHIDPDASYM 185
I C P+ + I IWD+ + I + + I++ ++
Sbjct: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCK 245
+ N +WN+ G + T + H C F+ DS+ L + D+T
Sbjct: 289 CTSSWDKNLKIWNVHTGEFRNCGACV--TLMQGHEGSVSSCHFARDSSFLISGGFDRTVA 346
Query: 246 IWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300
IW + +LS+K N W+ A S + ++I++AS D RLW +E
Sbjct: 347 IWDVAEG--YRKLSLKGHND------WVMDVAISNNKKWILSASKDRTMRLWNIE 393
Score = 63.9 bits (154), Expect = 2e-10
Identities = 54/231 (23%), Positives = 93/231 (40%), Gaps = 18/231 (7%)
Query: 77 PIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCL 136
P G +++ F D + +G DCT ++WD ++ + AP+ +
Sbjct: 94 PFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSI 153
Query: 137 HPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYV 196
+ + +I + WDL+T + + I S PD Y+ +
Sbjct: 154 TGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKYVVSG-------- 204
Query: 197 WNLTGGIGDEVTQLIPKTKI--PAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSL 254
+++ GI + I + HTR C F PDS +A+ S D+ KIW + S
Sbjct: 205 FDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT--SQ 262
Query: 255 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIK 305
T L+I + S C F+ ++ T+S D ++W V TGE +
Sbjct: 263 ATLLTITKAHSNAIS-----NCCFTFSGHFLCTSSWDKNLKIWNVHTGEFR 308
Score = 48.9 bits (115), Expect = 6e-06
Identities = 50/249 (20%), Positives = 100/249 (40%), Gaps = 18/249 (7%)
Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIR 66
++ D + A YD TVR W +G V++ D+ + + + +PD + +
Sbjct: 152 SITGDSSRVIAASYDKTVRAWDLETGKLLWKVRY-DTFIVSCKFSPDGKYVVSGFDVDHG 210
Query: 67 MYDLNSNNPNPI-ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSR-NLQCQRI 124
+ +++ N + + D ++I S F D + + + D +IWD+ S+ L
Sbjct: 211 ICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITK 270
Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ------LIPEPEVSITSAHI 178
NA NC C + L + IW++ T L+ E S++S H
Sbjct: 271 AHSNAISNC-CFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHF 329
Query: 179 DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATC 238
D+S++ + +W++ G K + H + + S + + +
Sbjct: 330 ARDSSFLISGGFDRTVAIWDVAEG--------YRKLSLKGHNDWVMDVAISNNKKWILSA 381
Query: 239 SADQTCKIW 247
S D+T ++W
Sbjct: 382 SKDRTMRLW 390
Score = 47.0 bits (110), Expect = 2e-05
Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 12/98 (12%)
Query: 212 PKTKIP-----AHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPG 266
P +KIP H C F D T L + S D T K+W + S++ + + P
Sbjct: 89 PLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAP- 147
Query: 267 ESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEI 304
+ C+ +GDS ++ AS D R W +ETG++
Sbjct: 148 ------VVECSITGDSSRVIAASYDKTVRAWDLETGKL 179
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 72.8 bits (177), Expect = 4e-13
Identities = 66/281 (23%), Positives = 120/281 (42%), Gaps = 17/281 (6%)
Query: 15 LATAGYDHTVRFWQAHSGICTR--TVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLN 71
LA+AG+D + W + G C T++ V L D SM+ +A + ++D
Sbjct: 81 LASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD-- 137
Query: 72 SNNPNPIISYDGVNKNIASVGFHEDG-RWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP 130
S + G + S G + + TG +D T ++WD+R + + FQ
Sbjct: 138 SETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKK--AAIQTFQNTYQ 195
Query: 131 INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNS 190
+ V + ++I G I +WDL+ + + S+T + + SY+ +
Sbjct: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS 250
VW++ E I + + + L+C +SPD + +A SAD+ +W T+
Sbjct: 256 DNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTT 315
Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291
+ ++ +L +G+ E AF D I++ASSD
Sbjct: 316 SRRILYKLPGHAGSINE--------VAFHPDEPIIISASSD 348
Score = 52.8 bits (125), Expect = 4e-07
Identities = 42/194 (21%), Positives = 80/194 (41%), Gaps = 13/194 (6%)
Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDL 70
P ++ T D TV+ W +T Q+ QV A+ I + G + I+++DL
Sbjct: 164 PQLVCTGSDDGTVKLWDIRKKAAIQTFQNT-YQVLAVTFNDTSDQIISGGIDNDIKVWDL 222
Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLR--SRNLQCQRIFQVN 128
N + G ++ + +G ++ + D T R+WD+R + +C +IFQ N
Sbjct: 223 RQNKLT--YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGN 280
Query: 129 AP------INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDA 182
+ C P+ +++ G +++WD + +P SI PD
Sbjct: 281 VHNFEKNLLRC-SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 339
Query: 183 SYMAAVNSTGNCYV 196
+ + +S Y+
Sbjct: 340 PIIISASSDKRLYM 353
Score = 45.4 bits (106), Expect = 7e-05
Identities = 47/282 (16%), Positives = 112/282 (39%), Gaps = 13/282 (4%)
Query: 42 DSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY 101
+ +V + P+ S +A+AG+ + + + + + G + + + ++ DG ++
Sbjct: 66 EGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLF 125
Query: 102 TGGEDCTARIWDLRSRNLQCQRIFQVNAPIN-CVCLHPNQAELIVGDQSGAIHIWDLKTD 160
+ D T +WD + + +R+ + +N C + G G + +WD++
Sbjct: 126 SASTDKTVAVWDSETGE-RVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKK 184
Query: 161 HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT 220
Q + + + + + + + + VW+L +++T + H
Sbjct: 185 AAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ---NKLTYTMR-----GHA 235
Query: 221 RYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTE-LSIKSGNPGESSRGWMWGCAFS 279
S + + L + + D T ++W F+ + I GN + + C++S
Sbjct: 236 DSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL-RCSWS 294
Query: 280 GDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
D I S+D +W + I + GH ++ +AF+
Sbjct: 295 PDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
Score = 34.7 bits (78), Expect = 0.12
Identities = 23/104 (22%), Positives = 41/104 (39%), Gaps = 7/104 (6%)
Query: 212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG 271
P + H C+F P+ + LA+ D+ +W + + G+ G
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV--YGDCDNYATLKGHSGA---- 111
Query: 272 WMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 315
+ ++ D + +AS+D +W ETGE + GH V
Sbjct: 112 -VMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFV 154
Score = 30.4 bits (67), Expect = 2.2
Identities = 39/227 (17%), Positives = 77/227 (33%), Gaps = 24/227 (10%)
Query: 77 PIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVC- 135
PI+ G + FH +G + + G D +W++ C + V
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYG---DCDNYATLKGHSGAVME 114
Query: 136 LHPNQ--AELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNS-TG 192
LH N + L + +WD +T + + + S + + S G
Sbjct: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDG 174
Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252
+W++ + Q +T L F+ S + + D K+W
Sbjct: 175 TVKLWDIRKKAAIQTFQ---------NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299
L + + + + G + S + Y+++ + DN R+W V
Sbjct: 226 KLTYTMRGHADS--------VTGLSLSSEGSYLLSNAMDNTVRVWDV 264
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 70.9 bits (172), Expect = 1e-12
Identities = 49/199 (24%), Positives = 91/199 (45%), Gaps = 14/199 (7%)
Query: 51 TPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTA 109
+PDR+ + ++ +R++ L + ++ Y G N + F G + +GG D A
Sbjct: 552 SPDRNYLLSSSEDGTVRLWSLQTFTC--LVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVA 609
Query: 110 RIWDLRSRNLQCQRIFQVN-APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPE 168
R+W + + Q RIF + A +NC HPN + G + +WD+ + ++
Sbjct: 610 RLW--ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTG 667
Query: 169 PEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRF 228
+ I S P+ ++A + G +W++ G+ ++ + K HT RF
Sbjct: 668 HKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL------MVGELK--GHTDTVCSLRF 719
Query: 229 SPDSTLLATCSADQTCKIW 247
S D +LA+ S D T ++W
Sbjct: 720 SRDGEILASGSMDNTVRLW 738
Score = 53.1 bits (126), Expect = 3e-07
Identities = 61/291 (20%), Positives = 113/291 (38%), Gaps = 33/291 (11%)
Query: 33 ICTRTVQHQDSQVNALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNPIISYDGVNKNIASV 91
IC T + + A++VT D S+IA +R++ + K + SV
Sbjct: 461 ICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTP-------------KKLRSV 507
Query: 92 GFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGA 151
D + +D RI D ++ + + + ++ + P+ P++ L+ + G
Sbjct: 508 KQASDLSLIDKESDDVLERIMDEKTAS-ELKILYGHSGPVYGASFSPDRNYLLSSSEDGT 566
Query: 152 IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211
+ +W L+T + P Y + +W T
Sbjct: 567 VRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLW---------ATDHY 617
Query: 212 PKTKIPAHTRYALQC-RFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSR 270
+I A + C RF P+S +AT SAD+T ++W N + + I +G+ G
Sbjct: 618 QPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVR---IFTGHKGP--- 671
Query: 271 GWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
+ FS + +++ T ++D LW + G + E GH V L F+
Sbjct: 672 --IHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
Score = 49.7 bits (117), Expect = 4e-06
Identities = 60/294 (20%), Positives = 111/294 (37%), Gaps = 37/294 (12%)
Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI-R 66
V D ++A D TVR W ++ +++ D S+I + R
Sbjct: 478 VTDDSSLIAGGFADSTVRVWSV-----------TPKKLRSVKQASDLSLIDKESDDVLER 526
Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 126
+ D + + I+ G + + F D ++ + ED T R+W L++ C ++
Sbjct: 527 IMDEKTASELKILY--GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT--FTCLVGYK 582
Query: 127 V-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQL--IPEPEVSITSAHIDPDAS 183
N P+ P + G +W TDH + L + P+++
Sbjct: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLW--ATDHYQPLRIFAGHLADVNCTRFHPNSN 640
Query: 184 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQT 243
Y+A ++ +W++ G ++ K P H+ FSP+ LAT + D
Sbjct: 641 YVATGSADRTVRLWDVLNG---NCVRIFTGHKGPIHS-----LTFSPNGRFLATGATDGR 692
Query: 244 CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297
+W + ++ EL + + FS D + + + S DN RLW
Sbjct: 693 VLLWDIGHGLMVGEL--------KGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 44.7 bits (104), Expect = 1e-04
Identities = 34/135 (25%), Positives = 57/135 (42%), Gaps = 8/135 (5%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDLNSN 73
+AT D TVR W +G C R +++L +P+ R + A + ++D+
Sbjct: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI--G 699
Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL--RSRNLQCQRIFQVNAPI 131
+ + G + S+ F DG + +G D T R+WD +L+ I
Sbjct: 700 HGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHI 759
Query: 132 NCVCLHPNQAELIVG 146
N L N EL++G
Sbjct: 760 N---LPENSQELLLG 771
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 70.9 bits (172), Expect = 1e-12
Identities = 71/299 (23%), Positives = 119/299 (39%), Gaps = 32/299 (10%)
Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYD 69
SD + + +A D +++ W + C RT+ + + + V DR ++ +++YD
Sbjct: 425 SDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYALCSFF-VPGDRQVVIGTKTGKLQLYD 482
Query: 70 LNSNNP-NPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL----------RSRN 118
L S N I ++DG + S+ D R TGG D + + WD + +
Sbjct: 483 LASGNLLETIDAHDGA---LWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLS 539
Query: 119 LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHI 178
++ R Q++ + CV PNQ L V + I+ + T + ++ + I
Sbjct: 540 VKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDI 599
Query: 179 DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATC 238
D + +A ++ N +W L GD L AH + +F P S L T
Sbjct: 600 SHDGALIATGSADRNVKIWGLD--FGDCHKSLF------AHDDSVMYLQFVPKSHLFFTA 651
Query: 239 SADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297
D K W F + L E +W A S Y+V++S D RLW
Sbjct: 652 GKDHKIKQWDADKFEHIQTL--------EGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
Score = 54.3 bits (129), Expect = 1e-07
Identities = 53/265 (20%), Positives = 105/265 (39%), Gaps = 21/265 (7%)
Query: 65 IRMYDLNSNNPNPI------ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN 118
+ +Y LN + P P I+ G ++ ++ F D + + D + +IW+ +
Sbjct: 389 VELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRST-- 445
Query: 119 LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHI 178
LQC R + C P ++++G ++G + ++DL + + + I + ++ S +
Sbjct: 446 LQCIRTMTCEYAL-CSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSL 504
Query: 179 DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQL---IPKTKIPAHTRYALQCRFSPDSTLL 235
PD + + W+ + TQ + +T+ L +SP+ LL
Sbjct: 505 SPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLL 564
Query: 236 ATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLAR 295
A D T KI+ L + + S D I T S+D +
Sbjct: 565 AVSLLDCTVKIFYVDTLKFFLSLY--------GHKLPVICMDISHDGALIATGSADRNVK 616
Query: 296 LWCVETGEIKREYGGHQKAVVCLAF 320
+W ++ G+ + H +V+ L F
Sbjct: 617 IWGLDFGDCHKSLFAHDDSVMYLQF 641
Score = 50.4 bits (119), Expect = 2e-06
Identities = 45/189 (23%), Positives = 76/189 (40%), Gaps = 21/189 (11%)
Query: 111 IWDLRS--RNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPE 168
IWDLR + L Q + Q + C+C P+ L VG + G+I I+ L +
Sbjct: 49 IWDLRKGEKILILQGLKQ---EVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNG 105
Query: 169 PEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRF 228
+ +IT+ D +A+ + + VW++ G ++ H Q F
Sbjct: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESG--------LYRLKGHKDAITQALF 157
Query: 229 SPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTA 288
+ LL T D K W L T+ K+ R +WG + + ++T
Sbjct: 158 LREKNLLVTSGKDTMVKWW-----DLDTQHCFKT---MVGHRTEVWGLVLLSEEKRLITG 209
Query: 289 SSDNLARLW 297
+SD+ R+W
Sbjct: 210 ASDSELRVW 218
Score = 41.2 bits (95), Expect = 0.001
Identities = 24/107 (22%), Positives = 48/107 (44%), Gaps = 3/107 (2%)
Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IR 66
+ D ++AT D V+ W G C +++ D V L+ P + AG H I+
Sbjct: 599 ISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIK 658
Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 113
+D ++ I + +G ++ I + G ++ + D + R+W+
Sbjct: 659 QWD--ADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Score = 33.9 bits (76), Expect = 0.20
Identities = 30/164 (18%), Positives = 60/164 (36%), Gaps = 16/164 (9%)
Query: 152 IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211
+ IWDL+ ++ + +T PD ++A G+ +++L G G+
Sbjct: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGN------ 100
Query: 212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG 271
H ++ LA+ S D +W N S + L + +
Sbjct: 101 --VTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL--------KGHKD 150
Query: 272 WMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 315
+ F + +VT+ D + + W ++T + GH+ V
Sbjct: 151 AITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEV 194
Score = 29.3 bits (64), Expect = 5.0
Identities = 14/58 (24%), Positives = 31/58 (53%), Gaps = 1/58 (1%)
Query: 14 ILATAGYDHTVRFWQAHSGICTRT-VQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 70
+L T+G D V++W + C +T V H+ + ++ ++ +I A +R++D+
Sbjct: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
sapiens]
Length = 275
Score = 70.1 bits (170), Expect = 3e-12
Identities = 42/164 (25%), Positives = 74/164 (45%), Gaps = 14/164 (8%)
Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVS-ITSAHIDPDASYMAAVNSTGNCYVWNLTG 201
L+ + + +WDLK D N + + + S PD+S + +V ++ ++WN+
Sbjct: 40 LVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM-- 97
Query: 202 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 261
D+ T + K+ H + C FSPD LLAT S D IW N ++ E
Sbjct: 98 ---DKYTMI---RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHL 151
Query: 262 SGNP-----GESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300
P G ++ W+ +FS D ++ + + D + R W ++
Sbjct: 152 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID 195
Score = 49.3 bits (116), Expect = 5e-06
Identities = 25/91 (27%), Positives = 41/91 (45%), Gaps = 8/91 (8%)
Query: 219 HTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF 278
H + C FSPDS++L + A + +W ++++ +L E + C F
Sbjct: 67 HQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKL--------EGHHHDVVACDF 118
Query: 279 SGDSQYIVTASSDNLARLWCVETGEIKREYG 309
S D + TAS D +W G+I E+G
Sbjct: 119 SPDGALLATASYDTRVYIWDPHNGDILMEFG 149
Score = 47.4 bits (111), Expect = 2e-05
Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 8/104 (7%)
Query: 219 HTRYALQCRFSPDSTL-LATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277
HT F+PD +L L + S D+T ++W + M ++ + W++ CA
Sbjct: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVL-------RGHQNWVYSCA 75
Query: 278 FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
FS DS + + + LW ++ + R+ GH VV F+
Sbjct: 76 FSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFS 119
Score = 40.0 bits (92), Expect = 0.003
Identities = 36/161 (22%), Positives = 63/161 (39%), Gaps = 23/161 (14%)
Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 70
D +L + G V W R ++ V A + +PD +++A A Y R+Y
Sbjct: 79 DSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYD-TRVYIW 137
Query: 71 NSNN-------------PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSR 117
+ +N P PI + ++ + SV F DG + + +D R W
Sbjct: 138 DPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW----- 192
Query: 118 NLQCQRIFQVNAPIN---CVCLHPNQAELIVGDQSGAIHIW 155
+ QV AP++ C + + L G G+++ W
Sbjct: 193 RIDEDYPVQV-APLSNGLCCAFSTDGSVLAAGTHDGSVYFW 232
Score = 37.7 bits (86), Expect = 0.014
Identities = 48/240 (20%), Positives = 82/240 (34%), Gaps = 46/240 (19%)
Query: 13 VILATAGYDHTVRFWQAHS-GICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLN 71
+IL +A D T+R W G + ++ + V + +PD SM+ + G ++ N
Sbjct: 38 LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKA-VFLWN 96
Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQ--RIFQVNA 129
+ I +G + ++ + F DG + T D IWD + ++ + +F
Sbjct: 97 MDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPT 156
Query: 130 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 189
PI + + G +H+ L D + ID D A
Sbjct: 157 PIFAGGANDRWVRSVSFSHDG-LHVASLADDK----------MVRFWRIDEDYPVQVAPL 205
Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT 249
S G C C FS D ++LA + D + W T
Sbjct: 206 SNGLC-------------------------------CAFSTDGSVLAAGTHDGSVYFWAT 234
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 67.4 bits (163), Expect = 2e-11
Identities = 56/229 (24%), Positives = 96/229 (41%), Gaps = 26/229 (11%)
Query: 96 DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155
D + + +G D T +IWD L+C+RI + + +CL ++ +I G + +W
Sbjct: 276 DDQKIVSGLRDNTIKIWD--KNTLECKRILTGHTG-SVLCLQYDERVIITGSSDSTVRVW 332
Query: 156 DLKTDHN-EQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKT 214
D+ T LI E + H+ + M + + VW++ T + +
Sbjct: 333 DVNTGEMLNTLIHHCEAVL---HLRFNNGMMVTCSKDRSIAVWDMASP-----TDITLRR 384
Query: 215 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMW 274
+ H F D + + S D+T K+W TS + L+ G
Sbjct: 385 VLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLN-----------GHKR 431
Query: 275 GCA-FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322
G A + +V+ SSDN RLW +E G R GH++ V C+ F++
Sbjct: 432 GIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN 480
Score = 60.1 bits (144), Expect = 3e-09
Identities = 42/191 (21%), Positives = 84/191 (43%), Gaps = 19/191 (9%)
Query: 135 CLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNC 194
CL + +++ G + I IWD T ++++ S+ D + +ST
Sbjct: 272 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVR- 330
Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSL 254
VW++ G+ + LI + H R+ ++ ++ TCS D++ +W ++ +
Sbjct: 331 -VWDVN--TGEMLNTLIHHCEAVLHLRF--------NNGMMVTCSKDRSIAVWDMASPTD 379
Query: 255 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKA 314
+T + G+ + D +YIV+AS D ++W T E R GH++
Sbjct: 380 ITLRRVLVGHRAAVN-------VVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRG 432
Query: 315 VVCLAFNDSVL 325
+ CL + D ++
Sbjct: 433 IACLQYRDRLV 443
Score = 41.2 bits (95), Expect = 0.001
Identities = 49/241 (20%), Positives = 95/241 (39%), Gaps = 16/241 (6%)
Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 70
D ++ T D TVR W ++G T+ H V L + M+ + + I ++D+
Sbjct: 316 DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFN-NGMMVTCSKDRSIAVWDM 374
Query: 71 NSNNPNPIISYDGVNKNIASVGFHE-DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 129
S P I + + A+V + D +++ + D T ++W+ + C+ + +N
Sbjct: 375 AS--PTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTST----CEFVRTLNG 428
Query: 130 -PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAV 188
CL ++ G I +WD++ +++ E + D A
Sbjct: 429 HKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAY 488
Query: 189 NSTGNCYVWNLTGGIGDEVT--QLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 246
+ G VW+L + L +T + H+ + +F D + + S D T I
Sbjct: 489 D--GKIKVWDLVAALDPRAPAGTLCLRTLV-EHSGRVFRLQF--DEFQIVSSSHDDTILI 543
Query: 247 W 247
W
Sbjct: 544 W 544
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 67.4 bits (163), Expect = 2e-11
Identities = 56/229 (24%), Positives = 96/229 (41%), Gaps = 26/229 (11%)
Query: 96 DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155
D + + +G D T +IWD L+C+RI + + +CL ++ +I G + +W
Sbjct: 312 DDQKIVSGLRDNTIKIWD--KNTLECKRILTGHTG-SVLCLQYDERVIITGSSDSTVRVW 368
Query: 156 DLKTDHN-EQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKT 214
D+ T LI E + H+ + M + + VW++ T + +
Sbjct: 369 DVNTGEMLNTLIHHCEAVL---HLRFNNGMMVTCSKDRSIAVWDMASP-----TDITLRR 420
Query: 215 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMW 274
+ H F D + + S D+T K+W TS + L+ G
Sbjct: 421 VLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLN-----------GHKR 467
Query: 275 GCA-FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322
G A + +V+ SSDN RLW +E G R GH++ V C+ F++
Sbjct: 468 GIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN 516
Score = 60.1 bits (144), Expect = 3e-09
Identities = 42/191 (21%), Positives = 84/191 (43%), Gaps = 19/191 (9%)
Query: 135 CLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNC 194
CL + +++ G + I IWD T ++++ S+ D + +ST
Sbjct: 308 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVR- 366
Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSL 254
VW++ G+ + LI + H R+ ++ ++ TCS D++ +W ++ +
Sbjct: 367 -VWDVN--TGEMLNTLIHHCEAVLHLRF--------NNGMMVTCSKDRSIAVWDMASPTD 415
Query: 255 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKA 314
+T + G+ + D +YIV+AS D ++W T E R GH++
Sbjct: 416 ITLRRVLVGHRAAVN-------VVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRG 468
Query: 315 VVCLAFNDSVL 325
+ CL + D ++
Sbjct: 469 IACLQYRDRLV 479
Score = 41.2 bits (95), Expect = 0.001
Identities = 49/241 (20%), Positives = 95/241 (39%), Gaps = 16/241 (6%)
Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 70
D ++ T D TVR W ++G T+ H V L + M+ + + I ++D+
Sbjct: 352 DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFN-NGMMVTCSKDRSIAVWDM 410
Query: 71 NSNNPNPIISYDGVNKNIASVGFHE-DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 129
S P I + + A+V + D +++ + D T ++W+ + C+ + +N
Sbjct: 411 AS--PTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTST----CEFVRTLNG 464
Query: 130 -PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAV 188
CL ++ G I +WD++ +++ E + D A
Sbjct: 465 HKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAY 524
Query: 189 NSTGNCYVWNLTGGIGDEVT--QLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 246
+ G VW+L + L +T + H+ + +F D + + S D T I
Sbjct: 525 D--GKIKVWDLVAALDPRAPAGTLCLRTLV-EHSGRVFRLQF--DEFQIVSSSHDDTILI 579
Query: 247 W 247
W
Sbjct: 580 W 580
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 66.6 bits (161), Expect = 3e-11
Identities = 44/178 (24%), Positives = 76/178 (42%), Gaps = 13/178 (7%)
Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202
L+ Q G + IWD T + IP + + P +Y+A C ++NL
Sbjct: 70 LVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129
Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS 262
G+ + ++P HT Y CRF DS ++ T S D TC +W T + S
Sbjct: 130 EGN----VRVSRELPGHTGYLSCCRFLDDSQIV-TSSGDTTCALWDIETAQQTTTFTGHS 184
Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320
G+ + + S D + V+ + D ++LW + G ++ + GH + ++F
Sbjct: 185 GD--------VMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSF 234
Score = 50.1 bits (118), Expect = 3e-06
Identities = 33/110 (30%), Positives = 51/110 (46%), Gaps = 13/110 (11%)
Query: 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIW----RTSNFSLMTELSIKSGNPGESSRG 271
IP + + + C ++P +A D C I+ R N + EL PG + G
Sbjct: 93 IPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSREL------PGHT--G 144
Query: 272 WMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
++ C F DSQ IVT+S D LW +ET + + GH V+ L+ +
Sbjct: 145 YLSCCRFLDDSQ-IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLS 193
Score = 47.4 bits (111), Expect = 2e-05
Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 21 DHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI-RMYDLNSNNPNPII 79
D + + W G+C ++ S +NA+ P+ A R++DL ++ +
Sbjct: 205 DASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLY 264
Query: 80 SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 113
S+D + I SV F + GR + G +D +WD
Sbjct: 265 SHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWD 298
Score = 45.1 bits (105), Expect = 9e-05
Identities = 38/186 (20%), Positives = 74/186 (39%), Gaps = 4/186 (2%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDLNSN 73
+ T+ D T W + T T V +L ++PD R+ ++ A +++D+
Sbjct: 157 IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDG 216
Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS-RNLQCQRIFQVNAPIN 132
S+ G +I +V F +G TG +D T R++DLR+ + L + I
Sbjct: 217 MCRQ--SFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGIT 274
Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTG 192
V + L+ G ++WD ++ + ++ + D +A +
Sbjct: 275 SVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334
Query: 193 NCYVWN 198
+WN
Sbjct: 335 FLRIWN 340
Score = 44.7 bits (104), Expect = 1e-04
Identities = 42/237 (17%), Positives = 83/237 (35%), Gaps = 16/237 (6%)
Query: 88 IASVGFHEDGRWMYTGGEDCTARIWDLRSR--NLQCQRIFQVNAPINCVCLHPNQAELIV 145
+ + + G ++ GG D I++L++R N++ R + C + ++++
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVT 159
Query: 146 GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGD 205
+WD++T + S + PD + + +W++ G+
Sbjct: 160 SSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMC- 218
Query: 206 EVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNP 265
+ H F P+ AT S D TC++ F L + + +
Sbjct: 219 -------RQSFTGHVSDINAVSFFPNGYAFATGSDDATCRL-----FDLRADQELLLYSH 266
Query: 266 GESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322
G + AFS + ++ D +W G+ GH V CL D
Sbjct: 267 DNIICG-ITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTD 322
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 66.2 bits (160), Expect = 4e-11
Identities = 41/154 (26%), Positives = 73/154 (47%), Gaps = 15/154 (9%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMYDLN-- 71
L +A D TV+ W AH G C T++ V AL D+ ++A+AG + I ++D+N
Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTL 149
Query: 72 -----SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 126
SNN S G +I S+ ++ G + +G + R+WD R+ C ++ +
Sbjct: 150 TALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT----CAKLMK 205
Query: 127 VNA---PINCVCLHPNQAELIVGDQSGAIHIWDL 157
+ + + L+ + + + G G I +W L
Sbjct: 206 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL 239
Score = 33.5 bits (75), Expect = 0.26
Identities = 51/286 (17%), Positives = 98/286 (34%), Gaps = 62/286 (21%)
Query: 45 VNALEVTPDRSMIAAAGYQHI-RMYDLNSNNPNPIISY-----DGVNKNIASVGFHEDGR 98
VNAL++ P + + AG I R++ +N + +P I+ D VN + +G+
Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCC----NGK 88
Query: 99 WMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVG-DQSGAIHIWDL 157
+ + D T ++W+ C + + + EL+ I +WD+
Sbjct: 89 TLISASSDTTVKVWNAHKGF--CMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDV 146
Query: 158 KTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIP 217
T V+ +S + D+ Y A+N G
Sbjct: 147 NT-LTALTASNNTVTTSSLSGNKDSIYSLAMNQLG------------------------- 180
Query: 218 AHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277
T++ + S ++ ++W + + +L + N +
Sbjct: 181 ---------------TIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDN--------VKALL 217
Query: 278 FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323
+ D ++ SSD RLW + Y H + V L ND+
Sbjct: 218 LNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDA 263
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 63.9 bits (154), Expect = 2e-10
Identities = 42/178 (23%), Positives = 76/178 (42%), Gaps = 13/178 (7%)
Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202
L+ Q G + +WD T + IP + + P +++A C ++NL
Sbjct: 70 LVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSR 129
Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS 262
G+ ++ AHT Y CRF D+ ++ T S D TC +W + + ++
Sbjct: 130 EGNVKVS----RELSAHTGYLSCCRFLDDNNIV-TSSGDTTCALW---DIETGQQKTVFV 181
Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320
G+ G+ A S D ++ + D A+LW V G ++ + GH+ + + F
Sbjct: 182 GHTGDCM-----SLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICF 234
Score = 51.6 bits (122), Expect = 9e-07
Identities = 36/147 (24%), Positives = 62/147 (42%), Gaps = 13/147 (8%)
Query: 173 ITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS 232
I + H D+ + + + G VW+ T + IP + + + C ++P
Sbjct: 58 IYAMHWATDSKLLVSASQDGKLIVWD------SYTTNKVHA--IPLRSSWVMTCAYAPSG 109
Query: 233 TLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDN 292
+A D C I+ + E ++K + G++ C F D+ IVT+S D
Sbjct: 110 NFVACGGLDNMCSIYNLKS----REGNVKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDT 164
Query: 293 LARLWCVETGEIKREYGGHQKAVVCLA 319
LW +ETG+ K + GH + LA
Sbjct: 165 TCALWDIETGQQKTVFVGHTGDCMSLA 191
Score = 50.8 bits (120), Expect = 2e-06
Identities = 31/153 (20%), Positives = 66/153 (43%), Gaps = 8/153 (5%)
Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIR 66
V D + + D + + W G C +T +S +NA+ P+ I R
Sbjct: 192 VSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCR 251
Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 126
++DL ++ S++ + I SV F GR ++ G +D +WD +++ +R+
Sbjct: 252 LFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWD----SMKSERVGI 307
Query: 127 VNA---PINCVCLHPNQAELIVGDQSGAIHIWD 156
++ ++C+ + + + G + IW+
Sbjct: 308 LSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 48.1 bits (113), Expect = 1e-05
Identities = 41/198 (20%), Positives = 77/198 (38%), Gaps = 15/198 (7%)
Query: 53 DRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW 112
D +++ ++G ++D+ + + + G + S+ D +G D +A++W
Sbjct: 154 DNNIVTSSGDTTCALWDIETGQQKTV--FVGHTGDCMSLAVSPDFNLFISGACDASAKLW 211
Query: 113 DLRSRNLQCQRIFQVN-APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171
D+R C++ F + + IN +C PN + G + ++DL+ D +
Sbjct: 212 DVREGT--CRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESI 269
Query: 172 --SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFS 229
ITS + A NC VW+ + E + + H +
Sbjct: 270 ICGITSVAFSLSGRLLFAGYDDFNCNVWD---SMKSERVGI-----LSGHDNRVSCLGVT 321
Query: 230 PDSTLLATCSADQTCKIW 247
D +AT S D KIW
Sbjct: 322 ADGMAVATGSWDSFLKIW 339
Score = 37.7 bits (86), Expect = 0.014
Identities = 49/285 (17%), Positives = 103/285 (36%), Gaps = 17/285 (5%)
Query: 36 RTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHE 95
RT++ +++ A+ D ++ +A Q ++ +S N + + + + + +
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSAS-QDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAP 107
Query: 96 DGRWMYTGGEDCTARIWDLRSR--NLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIH 153
G ++ GG D I++L+SR N++ R + C + ++
Sbjct: 108 SGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCA 167
Query: 154 IWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPK 213
+WD++T + + S + PD + + + +W++ G +
Sbjct: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG--------TCR 219
Query: 214 TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM 273
H F P+ + T S D +C++ F L + + + ES +
Sbjct: 220 QTFTGHESDINAICFFPNGEAICTGSDDASCRL-----FDLRADQELICFS-HESIICGI 273
Query: 274 WGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318
AFS + + D +W E GH V CL
Sbjct: 274 TSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCL 318
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 63.5 bits (153), Expect = 2e-10
Identities = 42/178 (23%), Positives = 76/178 (42%), Gaps = 13/178 (7%)
Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202
L+ Q G + IWD T + IP + + P +Y+A C ++NL
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129
Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS 262
G+ + ++ HT Y CRF D+ ++ T S D TC +W T + +
Sbjct: 130 EGN----VRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDIETGQQTTTFTGHT 184
Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320
G+ + + + D++ V+ + D A+LW V G ++ + GH+ + + F
Sbjct: 185 GD--------VMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICF 234
Score = 52.8 bits (125), Expect = 4e-07
Identities = 26/108 (24%), Positives = 49/108 (45%), Gaps = 1/108 (0%)
Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI- 65
++ D + + D + + W G+C +T +S +NA+ P+ + A
Sbjct: 191 SLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATC 250
Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 113
R++DL ++ S+D + I SV F + GR + G +D +WD
Sbjct: 251 RLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298
Score = 50.4 bits (119), Expect = 2e-06
Identities = 55/286 (19%), Positives = 94/286 (32%), Gaps = 57/286 (19%)
Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI-RM 67
G+D +L +A D + W +++ + + S V P + +A G +I +
Sbjct: 64 GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 123
Query: 68 YDLNSNNPNPIIS-------------------------------------------YDGV 84
Y+L + N +S + G
Sbjct: 124 YNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGH 183
Query: 85 NKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN-APINCVCLHPNQAEL 143
++ S+ D R +G D +A++WD+R C++ F + + IN +C PN
Sbjct: 184 TGDVMSLSLAPDTRLFVSGACDASAKLWDVREG--MCRQTFTGHESDINAICFFPNGNAF 241
Query: 144 IVGDQSGAIHIWDLKTDHNEQLIPEPEV--SITSAHIDPDASYMAAVNSTGNCYVWNLTG 201
G ++DL+ D + ITS + A NC VW+
Sbjct: 242 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK 301
Query: 202 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
V + H + D +AT S D KIW
Sbjct: 302 ADRAGV--------LAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
Score = 50.1 bits (118), Expect = 3e-06
Identities = 37/151 (24%), Positives = 63/151 (41%), Gaps = 21/151 (13%)
Query: 173 ITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS 232
I + H D+ + + + G +W+ T + IP + + + C ++P
Sbjct: 58 IYAMHWGTDSRLLVSASQDGKLIIWD------SYTTNKVHA--IPLRSSWVMTCAYAPSG 109
Query: 233 TLLATCSADQTCKIW----RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTA 288
+A D C I+ R N + EL+ G++ C F D+Q IVT+
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELA--------GHTGYLSCCRFLDDNQ-IVTS 160
Query: 289 SSDNLARLWCVETGEIKREYGGHQKAVVCLA 319
S D LW +ETG+ + GH V+ L+
Sbjct: 161 SGDTTCALWDIETGQQTTTFTGHTGDVMSLS 191
Score = 42.0 bits (97), Expect = 7e-04
Identities = 48/289 (16%), Positives = 105/289 (36%), Gaps = 17/289 (5%)
Query: 36 RTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHE 95
RT++ +++ A+ D ++ +A Q ++ +S N + + + + + +
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSAS-QDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107
Query: 96 DGRWMYTGGEDCTARIWDLRSR--NLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIH 153
G ++ GG D I++L++R N++ R + C + +++
Sbjct: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA 167
Query: 154 IWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPK 213
+WD++T + S + PD + + +W++ G+ +
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQT------ 221
Query: 214 TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM 273
H F P+ AT S D TC++ F L + + + + G +
Sbjct: 222 --FTGHESDINAICFFPNGNAFATGSDDATCRL-----FDLRADQELMTYSHDNIICG-I 273
Query: 274 WGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322
+FS + ++ D +W + GH V CL D
Sbjct: 274 TSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 322
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 63.5 bits (153), Expect = 2e-10
Identities = 53/236 (22%), Positives = 95/236 (40%), Gaps = 40/236 (16%)
Query: 96 DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155
D + +G D + +IWD S L+C ++ + + +CL ++ ++ G + +W
Sbjct: 249 DDEKIISGLRDNSIKIWDKTS--LECLKVLTGHTG-SVLCLQYDERVIVTGSSDSTVRVW 305
Query: 156 DLKTD--------HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207
D+ T HNE ++ H+ M + + VW++
Sbjct: 306 DVNTGEVLNTLIHHNEAVL----------HLRFSNGLMVTCSKDRSIAVWDMASA----- 350
Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267
T + + + H F D + + S D+T K+W TS + L+
Sbjct: 351 TDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLN-------- 400
Query: 268 SSRGWMWGCA-FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322
G G A + +V+ SSDN RLW +E G R GH++ V C+ F++
Sbjct: 401 ---GHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN 453
Score = 60.5 bits (145), Expect = 2e-09
Identities = 51/214 (23%), Positives = 91/214 (42%), Gaps = 20/214 (9%)
Query: 112 WDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171
W NLQ + N+ CL + ++I G + +I IWD + +++
Sbjct: 223 WRCGRHNLQRIQCRSENSK-GVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTG 281
Query: 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD 231
S+ D + +ST VW++ G+ + LI H L RFS
Sbjct: 282 SVLCLQYDERVIVTGSSDSTVR--VWDVN--TGEVLNTLIH------HNEAVLHLRFS-- 329
Query: 232 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291
+ L+ TCS D++ +W ++ + +T + G+ + D +YIV+AS D
Sbjct: 330 NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVN-------VVDFDDKYIVSASGD 382
Query: 292 NLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325
++W T E R GH++ + CL + D ++
Sbjct: 383 RTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLV 416
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/190 (20%), Positives = 77/190 (40%), Gaps = 49/190 (25%)
Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQV------NALEVT------------- 51
D ++ T D TVR W ++G T+ H + V N L VT
Sbjct: 289 DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMA 348
Query: 52 -----------------------PDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNI 88
D+ +++A+G + I+++ +++ + + +G + I
Sbjct: 349 SATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW--STSTCEFVRTLNGHKRGI 406
Query: 89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQ 148
A + + + R + +G D T R+WD+ C R+ + + + C+ + ++ G
Sbjct: 407 ACLQYRD--RLVVSGSSDNTIRLWDIECG--ACLRVLEGHEEL-VRCIRFDNKRIVSGAY 461
Query: 149 SGAIHIWDLK 158
G I +WDL+
Sbjct: 462 DGKIKVWDLQ 471
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 63.5 bits (153), Expect = 2e-10
Identities = 44/187 (23%), Positives = 73/187 (39%), Gaps = 11/187 (5%)
Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124
IR +DL S + Y G + + + +G D TAR+W R +
Sbjct: 366 IRYWDLGSFTNT--VLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSF-DRTYPLRIY 422
Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 184
A ++CV HPN L G + +W + ++ +L + S P+ Y
Sbjct: 423 AGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKY 482
Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 244
+A+ +W+L G ++ HT FSPDS L+A+ S D +
Sbjct: 483 LASAGEDQRLKLWDLASG--------TLYKELRGHTDNITSLTFSPDSGLIASASMDNSV 534
Query: 245 KIWRTSN 251
++W N
Sbjct: 535 RVWDIRN 541
Score = 55.8 bits (133), Expect = 5e-08
Identities = 63/294 (21%), Positives = 113/294 (38%), Gaps = 38/294 (12%)
Query: 33 ICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH--IRMYDLNSNNPNPIISYDGVNKNIAS 90
IC + + +N E++PD S + AAG+ + I+++ L S V++ +
Sbjct: 259 ICFYAFYNTEQLLNTAEISPD-SKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLA 317
Query: 91 VGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSG 150
E+ ED A +++ C P+ + + L+ +
Sbjct: 318 CDILEE-----EDDEDDNAGT-EMKILRGHC-------GPVYSTRFLADSSGLLSCSEDM 364
Query: 151 AIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQL 210
+I WDL + N L + I P + Y A+ + +W+ +
Sbjct: 365 SIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFD--------RT 416
Query: 211 IPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE--- 267
P H +F P+S LAT S D+T ++W S + GN
Sbjct: 417 YPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLW-----------SAQQGNSVRLFT 465
Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
RG + AFS + +Y+ +A D +LW + +G + +E GH + L F+
Sbjct: 466 GHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFS 519
Score = 49.7 bits (117), Expect = 4e-06
Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMYDLNSN 73
LAT D TVR W A G R V +L +P+ +A+AG Q ++++DL S
Sbjct: 441 LATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG 500
Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS 116
+ G NI S+ F D + + D + R+WD+R+
Sbjct: 501 TLYKELR--GHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 37.7 bits (86), Expect = 0.014
Identities = 24/99 (24%), Positives = 46/99 (46%), Gaps = 10/99 (10%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDL--- 70
LA+AG D ++ W SG + ++ + +L +PD +IA+A + +R++D+
Sbjct: 483 LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNT 542
Query: 71 ------NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTG 103
+ ++ + Y G N+ SV F + TG
Sbjct: 543 YCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTG 581
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 63.5 bits (153), Expect = 2e-10
Identities = 53/236 (22%), Positives = 95/236 (40%), Gaps = 40/236 (16%)
Query: 96 DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155
D + +G D + +IWD S L+C ++ + + +CL ++ ++ G + +W
Sbjct: 215 DDEKIISGLRDNSIKIWDKTS--LECLKVLTGHTG-SVLCLQYDERVIVTGSSDSTVRVW 271
Query: 156 DLKTD--------HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207
D+ T HNE ++ H+ M + + VW++
Sbjct: 272 DVNTGEVLNTLIHHNEAVL----------HLRFSNGLMVTCSKDRSIAVWDMASA----- 316
Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267
T + + + H F D + + S D+T K+W TS + L+
Sbjct: 317 TDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLN-------- 366
Query: 268 SSRGWMWGCA-FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322
G G A + +V+ SSDN RLW +E G R GH++ V C+ F++
Sbjct: 367 ---GHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN 419
Score = 60.5 bits (145), Expect = 2e-09
Identities = 51/214 (23%), Positives = 91/214 (42%), Gaps = 20/214 (9%)
Query: 112 WDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171
W NLQ + N+ CL + ++I G + +I IWD + +++
Sbjct: 189 WRCGRHNLQRIQCRSENSK-GVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTG 247
Query: 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD 231
S+ D + +ST VW++ G+ + LI H L RFS
Sbjct: 248 SVLCLQYDERVIVTGSSDSTVR--VWDVN--TGEVLNTLIH------HNEAVLHLRFS-- 295
Query: 232 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291
+ L+ TCS D++ +W ++ + +T + G+ + D +YIV+AS D
Sbjct: 296 NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVN-------VVDFDDKYIVSASGD 348
Query: 292 NLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325
++W T E R GH++ + CL + D ++
Sbjct: 349 RTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLV 382
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/190 (20%), Positives = 77/190 (40%), Gaps = 49/190 (25%)
Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQV------NALEVT------------- 51
D ++ T D TVR W ++G T+ H + V N L VT
Sbjct: 255 DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMA 314
Query: 52 -----------------------PDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNI 88
D+ +++A+G + I+++ +++ + + +G + I
Sbjct: 315 SATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW--STSTCEFVRTLNGHKRGI 372
Query: 89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQ 148
A + + + R + +G D T R+WD+ C R+ + + + C+ + ++ G
Sbjct: 373 ACLQYRD--RLVVSGSSDNTIRLWDIECG--ACLRVLEGHEEL-VRCIRFDNKRIVSGAY 427
Query: 149 SGAIHIWDLK 158
G I +WDL+
Sbjct: 428 DGKIKVWDLQ 437
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 63.5 bits (153), Expect = 2e-10
Identities = 53/236 (22%), Positives = 95/236 (40%), Gaps = 40/236 (16%)
Query: 96 DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155
D + +G D + +IWD S L+C ++ + + +CL ++ ++ G + +W
Sbjct: 236 DDEKIISGLRDNSIKIWDKTS--LECLKVLTGHTG-SVLCLQYDERVIVTGSSDSTVRVW 292
Query: 156 DLKTD--------HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207
D+ T HNE ++ H+ M + + VW++
Sbjct: 293 DVNTGEVLNTLIHHNEAVL----------HLRFSNGLMVTCSKDRSIAVWDMASA----- 337
Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267
T + + + H F D + + S D+T K+W TS + L+
Sbjct: 338 TDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLN-------- 387
Query: 268 SSRGWMWGCA-FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322
G G A + +V+ SSDN RLW +E G R GH++ V C+ F++
Sbjct: 388 ---GHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN 440
Score = 60.5 bits (145), Expect = 2e-09
Identities = 51/214 (23%), Positives = 91/214 (42%), Gaps = 20/214 (9%)
Query: 112 WDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171
W NLQ + N+ CL + ++I G + +I IWD + +++
Sbjct: 210 WRCGRHNLQRIQCRSENSK-GVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTG 268
Query: 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD 231
S+ D + +ST VW++ G+ + LI H L RFS
Sbjct: 269 SVLCLQYDERVIVTGSSDSTVR--VWDVN--TGEVLNTLIH------HNEAVLHLRFS-- 316
Query: 232 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291
+ L+ TCS D++ +W ++ + +T + G+ + D +YIV+AS D
Sbjct: 317 NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVN-------VVDFDDKYIVSASGD 369
Query: 292 NLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325
++W T E R GH++ + CL + D ++
Sbjct: 370 RTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLV 403
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/190 (20%), Positives = 77/190 (40%), Gaps = 49/190 (25%)
Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQV------NALEVT------------- 51
D ++ T D TVR W ++G T+ H + V N L VT
Sbjct: 276 DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMA 335
Query: 52 -----------------------PDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNI 88
D+ +++A+G + I+++ +++ + + +G + I
Sbjct: 336 SATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW--STSTCEFVRTLNGHKRGI 393
Query: 89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQ 148
A + + + R + +G D T R+WD+ C R+ + + + C+ + ++ G
Sbjct: 394 ACLQYRD--RLVVSGSSDNTIRLWDIECG--ACLRVLEGHEEL-VRCIRFDNKRIVSGAY 448
Query: 149 SGAIHIWDLK 158
G I +WDL+
Sbjct: 449 DGKIKVWDLQ 458
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 62.4 bits (150), Expect = 5e-10
Identities = 51/254 (20%), Positives = 96/254 (37%), Gaps = 19/254 (7%)
Query: 72 SNNPNPIIS--YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 129
S +P++ + G I S+ +G+ + T D +W+ + + + R
Sbjct: 3 SATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKP-HARAYRYVGHKD 61
Query: 130 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 189
+ V P+ L + + +W + S D ++A +
Sbjct: 62 VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATAS 121
Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT 249
+ VW++ + + HT + +FSPD L+ +CS D+T KIW T
Sbjct: 122 EDKSIKVWSMY--------RQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
Query: 250 SNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 309
+N + S S G+ F+ I +A SD ++W V ++ + Y
Sbjct: 174 TNKQCVNNFS--------DSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQ 225
Query: 310 GHQKAVVCLAFNDS 323
H V C++F+ S
Sbjct: 226 VHSGGVNCISFHPS 239
Score = 57.0 bits (136), Expect = 2e-08
Identities = 55/289 (19%), Positives = 104/289 (35%), Gaps = 18/289 (6%)
Query: 33 ICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVG 92
+ R + + + +L+++P+ +A A + M N Y G + SV
Sbjct: 9 VLERYFKGHKAAITSLDLSPNGKQLATASWDTFLML-WNFKPHARAYRYVGHKDVVTSVQ 67
Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAI 152
F G + + D T R+W + + + AP+ V + L + +I
Sbjct: 68 FSPHGNLLASASRDRTVRLW-IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSI 126
Query: 153 HIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIP 212
+W + + + A PD + + + +W+ T Q +
Sbjct: 127 KVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN------KQCV- 179
Query: 213 KTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGW 272
+A F+P T +A+ +DQT K+W L+ + SG S
Sbjct: 180 -NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS--- 235
Query: 273 MWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
F Y++TASSD ++ + G + GH V ++F+
Sbjct: 236 -----FHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFS 279
Score = 52.4 bits (124), Expect = 5e-07
Identities = 53/239 (22%), Positives = 93/239 (38%), Gaps = 14/239 (5%)
Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMYDLNS 72
+LA+A D TVR W + + V +++ + D +A A + I+++ +
Sbjct: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI- 131
+ S + F DGR + + ED T +IWD + N QC F +
Sbjct: 134 QRF--LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD--TTNKQCVNNFSDSVGFA 189
Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191
N V +P+ + + +WD++ + Q + P +Y+ +S
Sbjct: 190 NFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSD 249
Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS 250
G + +L G +LI + HT FS L A+ AD +WRT+
Sbjct: 250 GTLKILDLLEG------RLI--YTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
Score = 52.0 bits (123), Expect = 7e-07
Identities = 36/150 (24%), Positives = 71/150 (47%), Gaps = 6/150 (4%)
Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMY 68
+D LATA D +++ W + ++ V + +PD R +++ + + I+++
Sbjct: 112 ADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128
D + N + ++ V F+ G + + G D T ++WD+R L + +QV+
Sbjct: 172 D--TTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLL--QHYQVH 227
Query: 129 AP-INCVCLHPNQAELIVGDQSGAIHIWDL 157
+ +NC+ HP+ LI G + I DL
Sbjct: 228 SGGVNCISFHPSGNYLITASSDGTLKILDL 257
Score = 37.7 bits (86), Expect = 0.014
Identities = 27/115 (23%), Positives = 47/115 (40%), Gaps = 3/115 (2%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRS-MIAAAGYQHIRMYDLNSN 73
+A+AG D TV+ W + Q VN + P + +I A+ +++ DL
Sbjct: 201 IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEG 260
Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128
I + G + +V F + G +GG D +W L C+ + + N
Sbjct: 261 RL--IYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRN 313
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 62.0 bits (149), Expect = 7e-10
Identities = 48/229 (20%), Positives = 95/229 (41%), Gaps = 23/229 (10%)
Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA---PINCVCLHPNQAELIVGDQS 149
F EDG+ + + G D T +++ + +++ ++ A + C + +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETG----EKLLEIKAHEDEVLCCAFSTDDRFIATCSVD 678
Query: 150 GAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYV--WNLTGGIGDEV 207
+ IW+ T E + H + ++ + +C++ W+L
Sbjct: 679 KKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN------- 731
Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS----- 262
Q + + HT CRFSPD LLA+CSAD T K+W ++ + +++K
Sbjct: 732 -QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 790
Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGH 311
+P E + C++S D I+ A+ + + LW ++ + GH
Sbjct: 791 EDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGH 838
Score = 62.0 bits (149), Expect = 7e-10
Identities = 82/381 (21%), Positives = 139/381 (36%), Gaps = 103/381 (27%)
Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMI------AAAGYQH 64
D +LA+ D T++ W A S +++ + +N + D +I +A G +
Sbjct: 754 DDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI 813
Query: 65 I-----RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS--- 116
+ +++ N+++ + + G + V F DG T +D T R+W+ +
Sbjct: 814 MVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCK 873
Query: 117 ---------------------------RNLQC------QRIFQVNAPINCVCLHPNQAEL 143
R LQ Q + A ++C CL P+ +
Sbjct: 874 NSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYI 933
Query: 144 IVGDQSGAIHIWDL-------------KTDHNEQLIPEPEVSITSA-------------- 176
GD++GAI I +L KT + Q + + I+S+
Sbjct: 934 AFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDK 993
Query: 177 ------HIDPDASYMAAVNS-------TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYA 223
H + + NS G VWN+ G ++ H
Sbjct: 994 CIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEK--------DFVCHQGTV 1045
Query: 224 LQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ 283
L C S D+T ++ SAD+T KIW +F L+ L G+ G + AFS DS
Sbjct: 1046 LSCDISHDATKFSSTSADKTAKIW---SFDLLLPLHELRGH-----NGCVRCSAFSVDST 1097
Query: 284 YIVTASSDNLARLWCVETGEI 304
+ T + R+W V GE+
Sbjct: 1098 LLATGDDNGEIRIWNVSNGEL 1118
Score = 58.5 bits (140), Expect = 8e-09
Identities = 49/234 (20%), Positives = 94/234 (40%), Gaps = 35/234 (14%)
Query: 86 KNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQ----- 140
K + + F D + + + +D ++W N Q + C+ L +Q
Sbjct: 961 KTVWHIQFTADEKTLISSSDDAEIQVW-----NWQLDK---------CIFLRGHQETVKD 1006
Query: 141 ------AELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNC 194
+ L+ G + +W++ T + E+ + ++ S I DA+ ++ ++
Sbjct: 1007 FRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1066
Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSL 254
+W+ L+P ++ H FS DSTLLAT + +IW SN L
Sbjct: 1067 KIWSFD--------LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1118
Query: 255 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY 308
+ + S + GW+ FS D + +++A + W V TGE + +
Sbjct: 1119 LHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1170
Score = 55.1 bits (131), Expect = 8e-08
Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 8/105 (7%)
Query: 219 HTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF 278
HT FS D +A+C AD+T ++++ + E+ + CAF
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDE--------VLCCAF 665
Query: 279 SGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323
S D ++I T S D ++W TGE+ Y H + V C F +S
Sbjct: 666 STDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNS 710
Score = 51.6 bits (122), Expect = 9e-07
Identities = 53/264 (20%), Positives = 100/264 (37%), Gaps = 30/264 (11%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQ-HQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSN 73
+A+ G D T++ ++A +G ++ H+D + T DR + + + ++++ NS
Sbjct: 630 IASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIW--NSM 687
Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMY--TGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131
+ +YD ++ + F + TG DC ++WDL + + N+
Sbjct: 688 TGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVN 747
Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191
+C P+ L G + +WD + + + I + + DP V
Sbjct: 748 HCR-FSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE--DPQEDMEVIVK-- 802
Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKI--------------PAHTRYALQCRFSPDSTLLAT 237
C W+ G + K KI H + FSPD + T
Sbjct: 803 --CCSWSADGAR----IMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLT 856
Query: 238 CSADQTCKIWRTSNFSLMTELSIK 261
S DQT ++W T + + +K
Sbjct: 857 SSDDQTIRLWETKKVCKNSAVMLK 880
Score = 38.5 bits (88), Expect = 0.008
Identities = 39/192 (20%), Positives = 74/192 (38%), Gaps = 16/192 (8%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH---IRMYDLN 71
L + +D TV+ W +G + V + +++ D + ++ I +DL
Sbjct: 1015 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1074
Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ--CQRIFQVNA 129
P+ G N + F D + TG ++ RIW++ + L C + + A
Sbjct: 1075 L----PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1130
Query: 130 P-----INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 184
+ +C P+ LI G I W++ T + Q ++ H+ PD
Sbjct: 1131 ATHGGWVTDLCFSPDGKMLI--SAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKT 1188
Query: 185 MAAVNSTGNCYV 196
V++ G Y+
Sbjct: 1189 YVTVDNLGILYI 1200
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 62.0 bits (149), Expect = 7e-10
Identities = 47/233 (20%), Positives = 95/233 (40%), Gaps = 22/233 (9%)
Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA---PINCVCLHPNQAELIVGDQS 149
F EDG+ + + G D T +++ + +++ ++ A + C + +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETG----EKLLEIKAHEDEVLCCAFSTDDRFIATCSVD 678
Query: 150 GAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYV--WNLTGGIGDEV 207
+ IW+ T E + H + ++ + +C++ W+L
Sbjct: 679 KKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN------- 731
Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS----- 262
Q + + HT CRFSPD LLA+CSAD T K+W ++ + +++K
Sbjct: 732 -QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 790
Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 315
+P E + C++S D I+ A+ + + +G + + GH +
Sbjct: 791 EDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTI 843
Score = 58.9 bits (141), Expect = 6e-09
Identities = 65/327 (19%), Positives = 121/327 (37%), Gaps = 41/327 (12%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQ-HQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSN 73
+A+ G D T++ ++A +G ++ H+D + T DR + + + ++++ NS
Sbjct: 630 IASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIW--NSM 687
Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMY--TGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131
+ +YD ++ + F + TG DC ++WDL + + N+
Sbjct: 688 TGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVN 747
Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191
+C P+ L G + +WD + + + I + + DP V
Sbjct: 748 HCR-FSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE--DPQEDMEVIVK-- 802
Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKI---------------PAHTRYALQCRFSPDSTLLA 236
C W+ G + K KI H C FSP + L
Sbjct: 803 --CCSWSADGAR----IMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAV 856
Query: 237 TCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296
+ ++W T + S + + W+ G FS D +T+S D RL
Sbjct: 857 VALSQYCVELWNTDSRSKVADC--------RGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 908
Query: 297 WCVETGEIKREYGGHQKAVVCLAFNDS 323
W ET ++ + K V + F ++
Sbjct: 909 W--ETKKVCKNSAVMLKQEVDVVFQEN 933
Score = 58.5 bits (140), Expect = 8e-09
Identities = 49/234 (20%), Positives = 94/234 (40%), Gaps = 35/234 (14%)
Query: 86 KNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQ----- 140
K + + F D + + + +D ++W N Q + C+ L +Q
Sbjct: 1004 KTVWHIQFTADEKTLISSSDDAEIQVW-----NWQLDK---------CIFLRGHQETVKD 1049
Query: 141 ------AELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNC 194
+ L+ G + +W++ T + E+ + ++ S I DA+ ++ ++
Sbjct: 1050 FRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1109
Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSL 254
+W+ L+P ++ H FS DSTLLAT + +IW SN L
Sbjct: 1110 KIWSFD--------LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1161
Query: 255 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY 308
+ + S + GW+ FS D + +++A + W V TGE + +
Sbjct: 1162 LHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1213
Score = 56.2 bits (134), Expect = 4e-08
Identities = 74/324 (22%), Positives = 120/324 (37%), Gaps = 65/324 (20%)
Query: 22 HTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDLNSNNPNPIIS 80
+ V W S + S V+ + +PD S + ++ Q IR+++ N +
Sbjct: 862 YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVM 921
Query: 81 YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQ 140
K V F E+ + D R+ + R Q + A ++C CL P+
Sbjct: 922 L----KQEVDVVFQENEVMVLA--VDHIRRLQLINGRTGQID--YLTEAQVSCCCLSPHL 973
Query: 141 AELIVGDQSGAIHIWDL-------------KTDHNEQLIPEPEVSITSA----------- 176
+ GD++GAI I +L KT + Q + + I+S+
Sbjct: 974 QYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQ 1033
Query: 177 ---------HIDPDASYMAAVNS-------TGNCYVWNLTGGIGDEVTQLIPKTKIPAHT 220
H + + NS G VWN+ G ++ H
Sbjct: 1034 LDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEK--------DFVCHQ 1085
Query: 221 RYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG 280
L C S D+T ++ SAD+T KIW +F L+ L G+ G + AFS
Sbjct: 1086 GTVLSCDISHDATKFSSTSADKTAKIW---SFDLLLPLHELRGH-----NGCVRCSAFSV 1137
Query: 281 DSQYIVTASSDNLARLWCVETGEI 304
DS + T + R+W V GE+
Sbjct: 1138 DSTLLATGDDNGEIRIWNVSNGEL 1161
Score = 55.1 bits (131), Expect = 8e-08
Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 8/105 (7%)
Query: 219 HTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF 278
HT FS D +A+C AD+T ++++ + E+ + CAF
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDE--------VLCCAF 665
Query: 279 SGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323
S D ++I T S D ++W TGE+ Y H + V C F +S
Sbjct: 666 STDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNS 710
Score = 38.5 bits (88), Expect = 0.008
Identities = 39/192 (20%), Positives = 74/192 (38%), Gaps = 16/192 (8%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH---IRMYDLN 71
L + +D TV+ W +G + V + +++ D + ++ I +DL
Sbjct: 1058 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1117
Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ--CQRIFQVNA 129
P+ G N + F D + TG ++ RIW++ + L C + + A
Sbjct: 1118 L----PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1173
Query: 130 P-----INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 184
+ +C P+ LI G I W++ T + Q ++ H+ PD
Sbjct: 1174 ATHGGWVTDLCFSPDGKMLI--SAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKT 1231
Query: 185 MAAVNSTGNCYV 196
V++ G Y+
Sbjct: 1232 YVTVDNLGILYI 1243
Score = 32.7 bits (73), Expect = 0.45
Identities = 52/264 (19%), Positives = 97/264 (36%), Gaps = 57/264 (21%)
Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HI 65
T S ++LAT D ++ W + C T+ + VN +PD ++A+ +
Sbjct: 708 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTL 767
Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125
+++D S N I+ N+ ED + ED
Sbjct: 768 KLWDATSANERKSINVKQFFLNL------EDPQ------ED------------------- 796
Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV----SITSAHIDPD 181
+ + C + A ++V ++ I ++D+ H L+ E +I P
Sbjct: 797 -MEVIVKCCSWSADGARIMVAAKN-KIFLFDI---HTSGLLGEIHTGHHSTIQYCDFSPQ 851
Query: 182 ASYMAAVNSTGNCY-VWNLTGGIGDEVTQLIPKTKIP---AHTRYALQCRFSPDSTLLAT 237
+++A V + C +WN ++K+ H + FSPD + T
Sbjct: 852 -NHLAVVALSQYCVELWNTDS-----------RSKVADCRGHLSWVHGVMFSPDGSSFLT 899
Query: 238 CSADQTCKIWRTSNFSLMTELSIK 261
S DQT ++W T + + +K
Sbjct: 900 SSDDQTIRLWETKKVCKNSAVMLK 923
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 62.0 bits (149), Expect = 7e-10
Identities = 48/229 (20%), Positives = 95/229 (41%), Gaps = 23/229 (10%)
Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA---PINCVCLHPNQAELIVGDQS 149
F EDG+ + + G D T +++ + +++ ++ A + C + +
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETG----EKLLEIKAHEDEVLCCAFSTDDRFIATCSVD 667
Query: 150 GAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYV--WNLTGGIGDEV 207
+ IW+ T E + H + ++ + +C++ W+L
Sbjct: 668 KKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN------- 720
Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS----- 262
Q + + HT CRFSPD LLA+CSAD T K+W ++ + +++K
Sbjct: 721 -QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 779
Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGH 311
+P E + C++S D I+ A+ + + LW ++ + GH
Sbjct: 780 EDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGH 827
Score = 62.0 bits (149), Expect = 7e-10
Identities = 82/381 (21%), Positives = 139/381 (36%), Gaps = 103/381 (27%)
Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMI------AAAGYQH 64
D +LA+ D T++ W A S +++ + +N + D +I +A G +
Sbjct: 743 DDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI 802
Query: 65 I-----RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS--- 116
+ +++ N+++ + + G + V F DG T +D T R+W+ +
Sbjct: 803 MVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCK 862
Query: 117 ---------------------------RNLQC------QRIFQVNAPINCVCLHPNQAEL 143
R LQ Q + A ++C CL P+ +
Sbjct: 863 NSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYI 922
Query: 144 IVGDQSGAIHIWDL-------------KTDHNEQLIPEPEVSITSA-------------- 176
GD++GAI I +L KT + Q + + I+S+
Sbjct: 923 AFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDK 982
Query: 177 ------HIDPDASYMAAVNS-------TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYA 223
H + + NS G VWN+ G ++ H
Sbjct: 983 CIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEK--------DFVCHQGTV 1034
Query: 224 LQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ 283
L C S D+T ++ SAD+T KIW +F L+ L G+ G + AFS DS
Sbjct: 1035 LSCDISHDATKFSSTSADKTAKIW---SFDLLLPLHELRGH-----NGCVRCSAFSVDST 1086
Query: 284 YIVTASSDNLARLWCVETGEI 304
+ T + R+W V GE+
Sbjct: 1087 LLATGDDNGEIRIWNVSNGEL 1107
Score = 58.5 bits (140), Expect = 8e-09
Identities = 49/234 (20%), Positives = 94/234 (40%), Gaps = 35/234 (14%)
Query: 86 KNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQ----- 140
K + + F D + + + +D ++W N Q + C+ L +Q
Sbjct: 950 KTVWHIQFTADEKTLISSSDDAEIQVW-----NWQLDK---------CIFLRGHQETVKD 995
Query: 141 ------AELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNC 194
+ L+ G + +W++ T + E+ + ++ S I DA+ ++ ++
Sbjct: 996 FRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1055
Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSL 254
+W+ L+P ++ H FS DSTLLAT + +IW SN L
Sbjct: 1056 KIWSFD--------LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1107
Query: 255 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY 308
+ + S + GW+ FS D + +++A + W V TGE + +
Sbjct: 1108 LHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1159
Score = 55.1 bits (131), Expect = 8e-08
Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 8/105 (7%)
Query: 219 HTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF 278
HT FS D +A+C AD+T ++++ + E+ + CAF
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDE--------VLCCAF 654
Query: 279 SGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323
S D ++I T S D ++W TGE+ Y H + V C F +S
Sbjct: 655 STDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNS 699
Score = 51.6 bits (122), Expect = 9e-07
Identities = 53/264 (20%), Positives = 100/264 (37%), Gaps = 30/264 (11%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQ-HQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSN 73
+A+ G D T++ ++A +G ++ H+D + T DR + + + ++++ NS
Sbjct: 619 IASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIW--NSM 676
Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMY--TGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131
+ +YD ++ + F + TG DC ++WDL + + N+
Sbjct: 677 TGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVN 736
Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191
+C P+ L G + +WD + + + I + + DP V
Sbjct: 737 HCR-FSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE--DPQEDMEVIVK-- 791
Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKI--------------PAHTRYALQCRFSPDSTLLAT 237
C W+ G + K KI H + FSPD + T
Sbjct: 792 --CCSWSADGAR----IMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLT 845
Query: 238 CSADQTCKIWRTSNFSLMTELSIK 261
S DQT ++W T + + +K
Sbjct: 846 SSDDQTIRLWETKKVCKNSAVMLK 869
Score = 38.5 bits (88), Expect = 0.008
Identities = 39/192 (20%), Positives = 74/192 (38%), Gaps = 16/192 (8%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH---IRMYDLN 71
L + +D TV+ W +G + V + +++ D + ++ I +DL
Sbjct: 1004 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1063
Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ--CQRIFQVNA 129
P+ G N + F D + TG ++ RIW++ + L C + + A
Sbjct: 1064 L----PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1119
Query: 130 P-----INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 184
+ +C P+ LI G I W++ T + Q ++ H+ PD
Sbjct: 1120 ATHGGWVTDLCFSPDGKMLI--SAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKT 1177
Query: 185 MAAVNSTGNCYV 196
V++ G Y+
Sbjct: 1178 YVTVDNLGILYI 1189
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 62.0 bits (149), Expect = 7e-10
Identities = 47/233 (20%), Positives = 95/233 (40%), Gaps = 22/233 (9%)
Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA---PINCVCLHPNQAELIVGDQS 149
F EDG+ + + G D T +++ + +++ ++ A + C + +
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETG----EKLLEIKAHEDEVLCCAFSTDDRFIATCSVD 667
Query: 150 GAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYV--WNLTGGIGDEV 207
+ IW+ T E + H + ++ + +C++ W+L
Sbjct: 668 KKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN------- 720
Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS----- 262
Q + + HT CRFSPD LLA+CSAD T K+W ++ + +++K
Sbjct: 721 -QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 779
Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 315
+P E + C++S D I+ A+ + + +G + + GH +
Sbjct: 780 EDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTI 832
Score = 58.9 bits (141), Expect = 6e-09
Identities = 65/327 (19%), Positives = 121/327 (37%), Gaps = 41/327 (12%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQ-HQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSN 73
+A+ G D T++ ++A +G ++ H+D + T DR + + + ++++ NS
Sbjct: 619 IASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIW--NSM 676
Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMY--TGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131
+ +YD ++ + F + TG DC ++WDL + + N+
Sbjct: 677 TGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVN 736
Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191
+C P+ L G + +WD + + + I + + DP V
Sbjct: 737 HCR-FSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE--DPQEDMEVIVK-- 791
Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKI---------------PAHTRYALQCRFSPDSTLLA 236
C W+ G + K KI H C FSP + L
Sbjct: 792 --CCSWSADGAR----IMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAV 845
Query: 237 TCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296
+ ++W T + S + + W+ G FS D +T+S D RL
Sbjct: 846 VALSQYCVELWNTDSRSKVADC--------RGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 897
Query: 297 WCVETGEIKREYGGHQKAVVCLAFNDS 323
W ET ++ + K V + F ++
Sbjct: 898 W--ETKKVCKNSAVMLKQEVDVVFQEN 922
Score = 58.5 bits (140), Expect = 8e-09
Identities = 49/234 (20%), Positives = 94/234 (40%), Gaps = 35/234 (14%)
Query: 86 KNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQ----- 140
K + + F D + + + +D ++W N Q + C+ L +Q
Sbjct: 993 KTVWHIQFTADEKTLISSSDDAEIQVW-----NWQLDK---------CIFLRGHQETVKD 1038
Query: 141 ------AELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNC 194
+ L+ G + +W++ T + E+ + ++ S I DA+ ++ ++
Sbjct: 1039 FRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1098
Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSL 254
+W+ L+P ++ H FS DSTLLAT + +IW SN L
Sbjct: 1099 KIWSFD--------LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1150
Query: 255 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY 308
+ + S + GW+ FS D + +++A + W V TGE + +
Sbjct: 1151 LHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1202
Score = 56.2 bits (134), Expect = 4e-08
Identities = 74/324 (22%), Positives = 120/324 (37%), Gaps = 65/324 (20%)
Query: 22 HTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDLNSNNPNPIIS 80
+ V W S + S V+ + +PD S + ++ Q IR+++ N +
Sbjct: 851 YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVM 910
Query: 81 YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQ 140
K V F E+ + D R+ + R Q + A ++C CL P+
Sbjct: 911 L----KQEVDVVFQENEVMVLA--VDHIRRLQLINGRTGQID--YLTEAQVSCCCLSPHL 962
Query: 141 AELIVGDQSGAIHIWDL-------------KTDHNEQLIPEPEVSITSA----------- 176
+ GD++GAI I +L KT + Q + + I+S+
Sbjct: 963 QYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQ 1022
Query: 177 ---------HIDPDASYMAAVNS-------TGNCYVWNLTGGIGDEVTQLIPKTKIPAHT 220
H + + NS G VWN+ G ++ H
Sbjct: 1023 LDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEK--------DFVCHQ 1074
Query: 221 RYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG 280
L C S D+T ++ SAD+T KIW +F L+ L G+ G + AFS
Sbjct: 1075 GTVLSCDISHDATKFSSTSADKTAKIW---SFDLLLPLHELRGH-----NGCVRCSAFSV 1126
Query: 281 DSQYIVTASSDNLARLWCVETGEI 304
DS + T + R+W V GE+
Sbjct: 1127 DSTLLATGDDNGEIRIWNVSNGEL 1150
Score = 55.1 bits (131), Expect = 8e-08
Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 8/105 (7%)
Query: 219 HTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF 278
HT FS D +A+C AD+T ++++ + E+ + CAF
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDE--------VLCCAF 654
Query: 279 SGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323
S D ++I T S D ++W TGE+ Y H + V C F +S
Sbjct: 655 STDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNS 699
Score = 38.5 bits (88), Expect = 0.008
Identities = 39/192 (20%), Positives = 74/192 (38%), Gaps = 16/192 (8%)
Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH---IRMYDLN 71
L + +D TV+ W +G + V + +++ D + ++ I +DL
Sbjct: 1047 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1106
Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ--CQRIFQVNA 129
P+ G N + F D + TG ++ RIW++ + L C + + A
Sbjct: 1107 L----PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1162
Query: 130 P-----INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 184
+ +C P+ LI G I W++ T + Q ++ H+ PD
Sbjct: 1163 ATHGGWVTDLCFSPDGKMLI--SAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKT 1220
Query: 185 MAAVNSTGNCYV 196
V++ G Y+
Sbjct: 1221 YVTVDNLGILYI 1232
Score = 32.7 bits (73), Expect = 0.45
Identities = 52/264 (19%), Positives = 97/264 (36%), Gaps = 57/264 (21%)
Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HI 65
T S ++LAT D ++ W + C T+ + VN +PD ++A+ +
Sbjct: 697 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTL 756
Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125
+++D S N I+ N+ ED + ED
Sbjct: 757 KLWDATSANERKSINVKQFFLNL------EDPQ------ED------------------- 785
Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV----SITSAHIDPD 181
+ + C + A ++V ++ I ++D+ H L+ E +I P
Sbjct: 786 -MEVIVKCCSWSADGARIMVAAKN-KIFLFDI---HTSGLLGEIHTGHHSTIQYCDFSPQ 840
Query: 182 ASYMAAVNSTGNCY-VWNLTGGIGDEVTQLIPKTKIP---AHTRYALQCRFSPDSTLLAT 237
+++A V + C +WN ++K+ H + FSPD + T
Sbjct: 841 -NHLAVVALSQYCVELWNTDS-----------RSKVADCRGHLSWVHGVMFSPDGSSFLT 888
Query: 238 CSADQTCKIWRTSNFSLMTELSIK 261
S DQT ++W T + + +K
Sbjct: 889 SSDDQTIRLWETKKVCKNSAVMLK 912
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 61.6 bits (148), Expect = 9e-10
Identities = 67/321 (20%), Positives = 122/321 (38%), Gaps = 45/321 (14%)
Query: 14 ILATAGYDHTVRFWQAHSGI-----------CTRTVQHQ---DSQVNALEVTPDRSMIAA 59
+LA+ D T R W + C R H + V +L+ D +++A
Sbjct: 193 LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAM 252
Query: 60 AGYQHI-RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN 118
Y R++ N N + + + G I ++ +++ G ++ + G D T IWD +
Sbjct: 253 GSYDGFARIWTENGNLASTLGQHKGP---IFALKWNKKGNYVLSAGVDKTTIIWDAHTGE 309
Query: 119 LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHI 178
+ Q F +AP V N IH+ L DH + + +
Sbjct: 310 AKQQFPFH-SAPALDVDWQNNMTFASCSTDM-CIHVCRLGCDHPVKTFQGHTNEVNAIKW 367
Query: 179 DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-------- 230
DP +A+ + +W++ Q + AH++ ++SP
Sbjct: 368 DPSGMLLASCSDDMTLKIWSMK--------QDACVHDLQAHSKEIYTIKWSPTGPATSNP 419
Query: 231 -DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTAS 289
S +LA+ S D T ++W + T +K P ++ AFS D +Y+ + S
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQ-GVCTHTLMKHQEP-------VYSVAFSPDGKYLASGS 471
Query: 290 SDNLARLWCVETGEIKREYGG 310
D +W ++G + Y G
Sbjct: 472 FDKYVHIWNTQSGSLVHSYQG 492
Score = 57.0 bits (136), Expect = 2e-08
Identities = 64/242 (26%), Positives = 96/242 (39%), Gaps = 20/242 (8%)
Query: 85 NKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELI 144
NK++ S+ ++ DG + G D ARIW + NL + Q PI + + ++
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNL-ASTLGQHKGPIFALKWNKKGNYVL 292
Query: 145 VGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIG 204
IWD T +Q P S + +D + A ST C
Sbjct: 293 SAGVDKTTIIWDAHTGEAKQQFPFH--SAPALDVDWQNNMTFASCSTDMCI--------- 341
Query: 205 DEVTQL---IPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 261
V +L P HT ++ P LLA+CS D T KIW + + +L
Sbjct: 342 -HVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAH 400
Query: 262 SGNPGESSRGWMWGCAFSGDSQYIVTASS--DNLARLWCVETGEIKREYGGHQKAVVCLA 319
S + + G A S + I+ AS+ D+ RLW VE G HQ+ V +A
Sbjct: 401 S-KEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVA 459
Query: 320 FN 321
F+
Sbjct: 460 FS 461
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 3/113 (2%)
Query: 3 TSPGTVG-SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG 61
T P T + ++LA+A +D TVR W G+CT T+ V ++ +PD +A+
Sbjct: 412 TGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGS 471
Query: 62 YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL 114
+ ++ N+ + + + SY G I V ++ G + D + + DL
Sbjct: 472 FDKY-VHIWNTQSGSLVHSYQGTG-GIFEVCWNARGDKVGASASDGSVCVLDL 522
Score = 44.3 bits (103), Expect = 1e-04
Identities = 30/114 (26%), Positives = 47/114 (41%), Gaps = 7/114 (6%)
Query: 214 TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS------LMTELSIKSGNPGE 267
T + H C ++P S LLA+ S D T +IW + S L+ I+ G
Sbjct: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
S + ++ D + S D AR+W E G + G H+ + L +N
Sbjct: 233 PSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWN 285
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,192,247
Number of Sequences: 37866
Number of extensions: 562461
Number of successful extensions: 3533
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 167
Number of HSP's successfully gapped in prelim test: 112
Number of HSP's that attempted gapping in prelim test: 1424
Number of HSP's gapped (non-prelim): 1313
length of query: 326
length of database: 18,247,518
effective HSP length: 103
effective length of query: 223
effective length of database: 14,347,320
effective search space: 3199452360
effective search space used: 3199452360
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.