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Search of human proteins with 78000165
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
(1151 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 2317 0.0
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 1862 0.0
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 933 0.0
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 912 0.0
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 781 0.0
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 778 0.0
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 632 0.0
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 316 7e-86
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 270 6e-72
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 270 6e-72
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 258 2e-68
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 253 6e-67
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 253 6e-67
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 218 2e-56
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 214 4e-55
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 201 4e-51
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 201 4e-51
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 139 1e-32
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 115 2e-25
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 97 1e-19
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 85 3e-16
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 85 5e-16
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 85 5e-16
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 85 5e-16
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 77 7e-14
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 77 7e-14
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 77 7e-14
gi|39930351 dynamin binding protein [Homo sapiens] 72 3e-12
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 69 3e-11
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 65 3e-10
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 2317 bits (6005), Expect = 0.0
Identities = 1151/1151 (100%), Positives = 1151/1151 (100%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS
Sbjct: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
Query: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA
Sbjct: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
Query: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK
Sbjct: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
Query: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK
Sbjct: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
Query: 421 FPELPEIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSD 480
FPELPEIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSD
Sbjct: 421 FPELPEIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSD 480
Query: 481 LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP 540
LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP
Sbjct: 481 LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP 540
Query: 541 PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK 600
PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK
Sbjct: 541 PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK 600
Query: 601 PPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSA 660
PPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSA
Sbjct: 601 PPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSA 660
Query: 661 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 720
ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG
Sbjct: 661 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 720
Query: 721 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA 780
LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA
Sbjct: 721 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA 780
Query: 781 RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD 840
RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD
Sbjct: 781 RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD 840
Query: 841 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 900
IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF
Sbjct: 841 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 900
Query: 901 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 960
NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM
Sbjct: 901 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 960
Query: 961 DLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLS 1020
DLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLS
Sbjct: 961 DLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLS 1020
Query: 1021 TEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRR 1080
TEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRR
Sbjct: 1021 TEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRR 1080
Query: 1081 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 1140
VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT
Sbjct: 1081 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 1140
Query: 1141 FPGNYVKPLYL 1151
FPGNYVKPLYL
Sbjct: 1141 FPGNYVKPLYL 1151
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 1862 bits (4823), Expect = 0.0
Identities = 938/977 (96%), Positives = 943/977 (96%), Gaps = 22/977 (2%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS
Sbjct: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
Query: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA
Sbjct: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
Query: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK
Sbjct: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
Query: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK
Sbjct: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
Query: 421 FPELPEIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSD 480
FPELPEIQQTSEE +P + + P+ S+ DDDSD
Sbjct: 421 FPELPEIQQTSEEDNP---YTPTYQFPAST--------------PSPKSE-----DDDSD 458
Query: 481 LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP 540
LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP
Sbjct: 459 LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP 518
Query: 541 PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK 600
PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK
Sbjct: 519 PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK 578
Query: 601 PPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSA 660
PPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSA
Sbjct: 579 PPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSA 638
Query: 661 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 720
ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG
Sbjct: 639 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 698
Query: 721 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA 780
LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA
Sbjct: 699 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA 758
Query: 781 RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD 840
RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD
Sbjct: 759 RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD 818
Query: 841 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 900
IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF
Sbjct: 819 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 878
Query: 901 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 960
NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM
Sbjct: 879 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 938
Query: 961 DLPFSSSPSRSATASPQ 977
DLPFSSSPSRSATASPQ
Sbjct: 939 DLPFSSSPSRSATASPQ 955
Score = 367 bits (941), Expect = e-101
Identities = 181/201 (90%), Positives = 185/201 (92%), Gaps = 8/201 (3%)
Query: 959 YMDLPFSSSPSR--------SATASPQPWREESGQYERKAERGAGERGPGGPKISKKSCL 1010
++ LP SS S S+ + QPWREESGQYERKAERGAGERGPGGPKISKKSCL
Sbjct: 1092 FLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAGERGPGGPKISKKSCL 1151
Query: 1011 KPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGG 1070
KPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGG
Sbjct: 1152 KPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGG 1211
Query: 1071 SQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVG 1130
SQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVG
Sbjct: 1212 SQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVG 1271
Query: 1131 TSRRTKQFGTFPGNYVKPLYL 1151
TSRRTKQFGTFPGNYVKPLYL
Sbjct: 1272 TSRRTKQFGTFPGNYVKPLYL 1292
Score = 32.7 bits (73), Expect = 2.0
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 1085 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1144
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 788 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 845
Query: 1145 YVKPL 1149
Y++ L
Sbjct: 846 YIELL 850
Score = 32.7 bits (73), Expect = 2.0
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 810 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 867
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 1226 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1285
Query: 868 YIELL 872
Y++ L
Sbjct: 1286 YVKPL 1290
Score = 32.0 bits (71), Expect = 3.5
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 1075 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1134
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 855 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 911
Query: 1135 TKQFGTFPGNYV 1146
T + G FP YV
Sbjct: 912 TSRQGIFPITYV 923
Score = 32.0 bits (71), Expect = 3.5
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 877 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 933
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 1216 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1275
Query: 934 TSRQGIFPITYV 945
T + G FP YV
Sbjct: 1276 TKQFGTFPGNYV 1287
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 933 bits (2412), Expect = 0.0
Identities = 539/839 (64%), Positives = 586/839 (69%), Gaps = 87/839 (10%)
Query: 172 GQEGTARPPTPLGPLGCVPTIPA-TASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGS 230
GQ+ P + V IP T AS L PT D P + + RAS S
Sbjct: 22 GQDKATADPLRARSISAVKIIPVKTVKNASGLVLPT--DMDPTKICTGKG-AVTLRASSS 78
Query: 231 FAPISQTPPSFSPPPPLV-------------PPAPEDLRRVSEPDLTG-AVSSTDSSPLL 276
+ + PS SP P P + ++ R S D G A S+ ++
Sbjct: 79 Y----RETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGY 134
Query: 277 NEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVN-------PTIVLLQHNREQQKRLSSLSD 329
V +L SQ +P S+P+ A S ++ P L+ E +R+S +
Sbjct: 135 RSVHPNLPSDKSQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVS---E 191
Query: 330 PVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTE 389
P V DS+P + +S + +A V K + ++ I L
Sbjct: 192 PDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPS---VSKPSSAYPSTTIVNPTIVLLQHN 248
Query: 390 RSKDWYKTMFKQIHKLNRDTPE----ENPYFPTYKFPELP--EIQQTSEETKSCSVMSPR 443
R + K++ L+ E E PT + P P I++ +++ V S +
Sbjct: 249 REQQ------KRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQ 302
Query: 444 LECSGTVIAHCSLKLLDSSNPP----TSASQVAG-TADDDSDLYSPRYSFSEDTKSPLSV 498
+ S + + L ++ T Q+ DDDSDLYSPRYSFSEDTKSPLSV
Sbjct: 303 -DLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSV 361
Query: 499 PRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIY 558
PRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIY
Sbjct: 362 PRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIY 421
Query: 559 EYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILP 618
EYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILP
Sbjct: 422 EYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILP 481
Query: 619 REDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSS 678
REDRK SSAISPTPEISSETPGYIYSS
Sbjct: 482 REDRK----------------------------------SSAISPTPEISSETPGYIYSS 507
Query: 679 NFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRH 738
NFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRH
Sbjct: 508 NFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRH 567
Query: 739 FIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNER 798
FIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNER
Sbjct: 568 FIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNER 627
Query: 799 FGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHH 858
FGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHH
Sbjct: 628 FGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHH 687
Query: 859 GRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITL 918
GRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITL
Sbjct: 688 GRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITL 747
Query: 919 LRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ 977
LRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ
Sbjct: 748 LRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ 806
Score = 587 bits (1514), Expect = e-167
Identities = 427/1027 (41%), Positives = 534/1027 (51%), Gaps = 209/1027 (20%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSS P+S E R S
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSS-------------------PASPQETRQHESKPG 101
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
+P +A +R S A ++ AQP + Y
Sbjct: 102 ---LEPEPSSADEWRL---------SSSADANGNAQPSSLAAKGYR-------------- 135
Query: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
P +P+ S QRWPHHSQPARASGSFAPISQTPPS
Sbjct: 136 ------SVHPNLPSDKS------------------QRWPHHSQPARASGSFAPISQTPPS 171
Query: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA
Sbjct: 172 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 231
Query: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK
Sbjct: 232 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 291
Query: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRD + + Y P Y
Sbjct: 292 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRD-DDSDLYSPRYS 350
Query: 421 FPELPEIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSD 480
F SE+TKS + PR + + I + ++ P + S ++ + +D
Sbjct: 351 F---------SEDTKS-PLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERND 400
Query: 481 LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP 540
P DT+ + P+S E P +SS L + D P
Sbjct: 401 WEPP--DKKVDTRKYRAEPKSIYEYQ----------------PGKSSVLTNEKMSRDISP 442
Query: 541 PD---KKVDTRKYRAE-------PKSIYEYQPGKSSVLTNE-KMSRDISPEEIDLKNEPW 589
+ K K+ +E PK I++Y PG S+L E + S ISP P
Sbjct: 443 EEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKSSAISPTPEISSETPG 502
Query: 590 YKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLN- 648
Y + S K+ D PGD T+L+ + + ++ LE ++ L+
Sbjct: 503 YIYSSNFH----AVKRESDGAPGDL---------TSLENERQIYKSVLEGGDIPLQGLSG 549
Query: 649 -KAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSV 707
K PS++ + SP I P S ++R D D L +++ K
Sbjct: 550 LKRPSSSASTKDSESPRHFI----PADYLESTEEFIRRRHD----DKEKLLADQRRLKRE 601
Query: 708 LEGGDIPLQGLSGLKRPSSSASTKD--------SESPRHFIPADYLESTEEFIRRRHDDK 759
E DI + +G+ T + ++ + ++ + +F + K
Sbjct: 602 QEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLK 661
Query: 760 EKLL--ADQRRLKREQEEADIAARRH--TGVIPTHHQFITNERFGDLLNIDDTAKRKSGS 815
E L D + ++ ++ H G+ P + +LL + A+ K +
Sbjct: 662 ELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFP--------RTYIELLPPAEKAQPKKLT 713
Query: 816 -----EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTY 868
E A AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP TY
Sbjct: 714 PVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITY 773
Query: 869 IEL-----------------------------------------LPPAEK------AQPK 881
+++ L +EK AQ +
Sbjct: 774 VDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQR 833
Query: 882 KLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQG 938
++TP + + A +++ E+ R G+ + ++ + D+ W+ G T + G
Sbjct: 834 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG 893
Query: 939 IFPITYV 945
FP YV
Sbjct: 894 TFPGNYV 900
Score = 196 bits (499), Expect = 8e-50
Identities = 123/271 (45%), Positives = 155/271 (57%), Gaps = 19/271 (7%)
Query: 890 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 949
E A AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP TY++++
Sbjct: 645 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELLP 702
Query: 950 -----RPLVKNPVDYMDL--PFSSSPSRSATASPQPWRE-ESGQYERKAERGAGERGPGG 1001
+P PV ++ + T +R+ E R+ + E G
Sbjct: 703 PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 762
Query: 1002 PKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQA 1061
+ DV++ + + ++ P S P + + + Q H +A
Sbjct: 763 TSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRS------ATASPQLSHH--SLRA 814
Query: 1062 GRKAARRGGSQ-QPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 1120
G S QPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM
Sbjct: 815 GPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 874
Query: 1121 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 875 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 905
Score = 32.7 bits (73), Expect = 2.0
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 1085 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1144
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 639 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 696
Query: 1145 YVKPL 1149
Y++ L
Sbjct: 697 YIELL 701
Score = 32.7 bits (73), Expect = 2.0
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 810 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 867
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 839 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 898
Query: 868 YIELL 872
Y++ L
Sbjct: 899 YVKPL 903
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 912 bits (2357), Expect = 0.0
Identities = 563/988 (56%), Positives = 603/988 (61%), Gaps = 262/988 (26%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 88
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP
Sbjct: 89 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 148
Query: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
TPLGPLGCVPTI PA AS + +P +
Sbjct: 149 TPLGPLGCVPTI-------------------------------PATASAA------SPLT 171
Query: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
F +PP + S+P A +S +P+ SQ PS S P
Sbjct: 172 FPTLDDFIPPHLQRWPHHSQP----ARASGSFAPI------------SQTPPSFSPPPPL 215
Query: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
P + L +S+P V DS+P + +S + +A
Sbjct: 216 VPPAP----------------EDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAF 259
Query: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPE----ENPYF 416
V K + ++ I L R + K++ L+ E E
Sbjct: 260 PS---VSKPSSAYPSTTIVNPTIVLLQHNREQQ------KRLSSLSDPVSERRVGEQDSA 310
Query: 417 PTYKFPELP--EIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPP----TSASQ 470
PT + P P I++ +++ V S + + S + + L ++ T Q
Sbjct: 311 PTQEKPTSPGKAIEKRAKDDSRRVVKSTQ-DLSDVSMDEVGIPLRNTERSKDWYKTMFKQ 369
Query: 471 VAG-TADDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSL 529
+ DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSL
Sbjct: 370 IHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSL 429
Query: 530 KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPW 589
KSSSERNDWEPPDKKVDTRKYRAE
Sbjct: 430 KSSSERNDWEPPDKKVDTRKYRAE------------------------------------ 453
Query: 590 YKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNK 649
PK I++Y PG S+L TN EKM
Sbjct: 454 -------------PKSIYEYQPGKSSVL------TN----------------EKM----- 473
Query: 650 APSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLE 709
SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLE
Sbjct: 474 --------SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLE 525
Query: 710 GGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRL 769
GGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 526 GGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR---------------- 569
Query: 770 KREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQ 829
RRH DD EMRPARAKFDFKAQ
Sbjct: 570 -----------RRH----------------------DD-------KEMRPARAKFDFKAQ 589
Query: 830 TLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVL 889
TLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVL
Sbjct: 590 TLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVL 649
Query: 890 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 949
EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK
Sbjct: 650 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 709
Query: 950 RPLVKNPVDYMDLPFSSSPSRSATASPQ 977
RPLVKNPVDYMDLPFSSSPSRSATASPQ
Sbjct: 710 RPLVKNPVDYMDLPFSSSPSRSATASPQ 737
Score = 196 bits (498), Expect = 1e-49
Identities = 120/271 (44%), Positives = 146/271 (53%), Gaps = 39/271 (14%)
Query: 890 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 949
E A AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP TY++++
Sbjct: 576 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELLP 633
Query: 950 RPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSC 1009
P + + P + + E ++ + G +I
Sbjct: 634 ------PAE------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI----- 676
Query: 1010 LKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGE---------Q 1060
T R D N E PG FP + + +R
Sbjct: 677 -----------TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFS 725
Query: 1061 AGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 1120
+ + QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM
Sbjct: 726 SSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 785
Query: 1121 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 786 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 816
Score = 33.1 bits (74), Expect = 1.6
Identities = 18/65 (27%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 1085 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1144
R +++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 570 RRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 627
Query: 1145 YVKPL 1149
Y++ L
Sbjct: 628 YIELL 632
Score = 32.7 bits (73), Expect = 2.0
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 810 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 867
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 750 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 809
Query: 868 YIELL 872
Y++ L
Sbjct: 810 YVKPL 814
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 781 bits (2017), Expect = 0.0
Identities = 476/816 (58%), Positives = 522/816 (63%), Gaps = 145/816 (17%)
Query: 172 GQEGTARPPTPLGPLGCVPTIPA-TASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGS 230
GQ+ P + V IP T AS L PT D P + +G
Sbjct: 22 GQDKATADPLRARSISAVKIIPVKTVKNASGLVLPT--DMDPTKI-----------CTGK 68
Query: 231 FAPISQTPPSFSPPPPLVPPAPEDLRR-VSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQ 289
A + S+ P P +P++ R+ S+P L SS D L SS +
Sbjct: 69 GAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRL-----SSSADANGN 123
Query: 290 AFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSA-PTQEKP 348
A PS S + Y S V+P + ++ + S L + VS +G A P+ KP
Sbjct: 124 AQPS-SLAAKGYRS---VHPNLP-----SDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKP 174
Query: 349 TSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRD 408
+S S +V T L + +++ K + ++
Sbjct: 175 SSAYP---------STTIVNPTIVL--------------LQHNREQQKRLSSLSDPVSER 211
Query: 409 TPEENPYFPTYKFPELP--EIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPP- 465
E PT + P P I++ +++ V S + + S + + L ++
Sbjct: 212 RVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQ-DLSDVSMDEVGIPLRNTERSKD 270
Query: 466 ---TSASQVAG-TADDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLP 521
T Q+ DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLP
Sbjct: 271 WYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLP 330
Query: 522 LPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEE 581
LPARSSSLKSSSERNDWEPPDKKVDTRKYRAE
Sbjct: 331 LPARSSSLKSSSERNDWEPPDKKVDTRKYRAE---------------------------- 362
Query: 582 IDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADL 641
PK I++Y PG S+L TN
Sbjct: 363 ---------------------PKSIYEYQPGKSSVL------TN---------------- 379
Query: 642 EKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENER 701
EKM SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENER
Sbjct: 380 EKM-------------SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENER 426
Query: 702 QIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEK 761
QIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEK
Sbjct: 427 QIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEK 486
Query: 762 LLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPAR 821
LLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPAR
Sbjct: 487 LLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPAR 546
Query: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 881
AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK
Sbjct: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 606
Query: 882 KLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP 941
KLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP
Sbjct: 607 KLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP 666
Query: 942 ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ 977
ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ
Sbjct: 667 ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ 702
Score = 297 bits (760), Expect = 4e-80
Identities = 158/194 (81%), Positives = 165/194 (85%), Gaps = 8/194 (4%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQD++ P + V L+ TD + P
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS------PLLNEVSSSLIGTDSQAFPSVSKP 174
Query: 181 TPLGPLGCV--PTI 192
+ P + PTI
Sbjct: 175 SSAYPSTTIVNPTI 188
Score = 281 bits (720), Expect = 2e-75
Identities = 201/426 (47%), Positives = 239/426 (56%), Gaps = 44/426 (10%)
Query: 114 LSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQD-ATSSSAAQPEVIVVPLYLVNTDRG 172
+SS D A + LA P QD AT+ + V + V T +
Sbjct: 1 MSSECDGGSKAVMNGLA-----------PGSNGQDKATADPLRARSISAVKIIPVKTVKN 49
Query: 173 QEGTARPPTPLGPL------GCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPAR 226
G P T + P G V +++ +P + P H + +P+
Sbjct: 50 ASGLVLP-TDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSS 108
Query: 227 ASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGT 286
A S + P L A + R V P+L S DSSPLLNEVSSSLIGT
Sbjct: 109 ADEWRLSSSADANGNAQPSSL---AAKGYRSV-HPNLPSD-KSQDSSPLLNEVSSSLIGT 163
Query: 287 DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE 346
DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE
Sbjct: 164 DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE 223
Query: 347 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 406
KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN
Sbjct: 224 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 283
Query: 407 RDTPEENPYFPTYKFPELPEIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPT 466
RD + + Y P Y F SE+TKS + PR + + I + ++ P
Sbjct: 284 RD-DDSDLYSPRYSF---------SEDTKS-PLSVPRSKSEMSYIDGEKVVKRSATLPLP 332
Query: 467 SASQVAGTADDDSDLYSPRYSFSEDTKSPLSVPRS-----KSEMSYIDGEKVVKRSATLP 521
+ S ++ + +D P DT+ + P+S + S + EK+ SA P
Sbjct: 333 ARSSSLKSSSERNDWEPP--DKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKM--SSAISP 388
Query: 522 LPARSS 527
P SS
Sbjct: 389 TPEISS 394
Score = 196 bits (498), Expect = 1e-49
Identities = 120/271 (44%), Positives = 146/271 (53%), Gaps = 39/271 (14%)
Query: 890 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 949
E A AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP TY++++
Sbjct: 541 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELLP 598
Query: 950 RPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSC 1009
P + + P + + E ++ + G +I
Sbjct: 599 ------PAE------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI----- 641
Query: 1010 LKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGE---------Q 1060
T R D N E PG FP + + +R
Sbjct: 642 -----------TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFS 690
Query: 1061 AGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 1120
+ + QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM
Sbjct: 691 SSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 750
Query: 1121 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 751 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 781
Score = 32.7 bits (73), Expect = 2.0
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 1085 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1144
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 535 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 592
Query: 1145 YVKPL 1149
Y++ L
Sbjct: 593 YIELL 597
Score = 32.7 bits (73), Expect = 2.0
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 810 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 867
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 715 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 774
Query: 868 YIELL 872
Y++ L
Sbjct: 775 YVKPL 779
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 778 bits (2010), Expect = 0.0
Identities = 411/502 (81%), Positives = 414/502 (82%), Gaps = 84/502 (16%)
Query: 476 DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER 535
DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER
Sbjct: 244 DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER 303
Query: 536 NDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSE 595
NDWEPPDKKVDTRKYRAE
Sbjct: 304 NDWEPPDKKVDTRKYRAE------------------------------------------ 321
Query: 596 LEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANV 655
PK I++Y PG S+L TN EKM
Sbjct: 322 -------PKSIYEYQPGKSSVL------TN----------------EKM----------- 341
Query: 656 PQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPL 715
SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPL
Sbjct: 342 --SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPL 399
Query: 716 QGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEE 775
QGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEE
Sbjct: 400 QGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEE 459
Query: 776 ADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELP 835
ADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELP
Sbjct: 460 ADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELP 519
Query: 836 LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAI 895
LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAI
Sbjct: 520 LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAI 579
Query: 896 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN 955
AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN
Sbjct: 580 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN 639
Query: 956 PVDYMDLPFSSSPSRSATASPQ 977
PVDYMDLPFSSSPSRSATASPQ
Sbjct: 640 PVDYMDLPFSSSPSRSATASPQ 661
Score = 280 bits (717), Expect = 4e-75
Identities = 168/264 (63%), Positives = 188/264 (71%), Gaps = 20/264 (7%)
Query: 269 STDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 328
S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS
Sbjct: 105 SQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 164
Query: 329 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 388
DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT
Sbjct: 165 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 224
Query: 389 ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEETKSCSVMSPRLECSG 448
ERSKDWYKTMFKQIHKLNRD + + Y P Y F SE+TKS + PR +
Sbjct: 225 ERSKDWYKTMFKQIHKLNRD-DDSDLYSPRYSF---------SEDTKS-PLSVPRSKSEM 273
Query: 449 TVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTKSPLSVPRS-----KS 503
+ I + ++ P + S ++ + +D P DT+ + P+S
Sbjct: 274 SYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPP--DKKVDTRKYRAEPKSIYEYQPG 331
Query: 504 EMSYIDGEKVVKRSATLPLPARSS 527
+ S + EK+ SA P P SS
Sbjct: 332 KSSVLTNEKM--SSAISPTPEISS 353
Score = 197 bits (500), Expect = 6e-50
Identities = 117/194 (60%), Positives = 124/194 (63%), Gaps = 49/194 (25%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQD++ P + V L+ TD + P
Sbjct: 80 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS------PLLNEVSSSLIGTDSQAFPSVSKP 133
Query: 181 TPLGPLGCV--PTI 192
+ P + PTI
Sbjct: 134 SSAYPSTTIVNPTI 147
Score = 196 bits (498), Expect = 1e-49
Identities = 120/271 (44%), Positives = 146/271 (53%), Gaps = 39/271 (14%)
Query: 890 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 949
E A AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP TY++++
Sbjct: 500 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELLP 557
Query: 950 RPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSC 1009
P + + P + + E ++ + G +I
Sbjct: 558 ------PAE------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI----- 600
Query: 1010 LKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGE---------Q 1060
T R D N E PG FP + + +R
Sbjct: 601 -----------TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFS 649
Query: 1061 AGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 1120
+ + QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM
Sbjct: 650 SSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 709
Query: 1121 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 710 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 740
Score = 32.7 bits (73), Expect = 2.0
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 1085 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1144
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 494 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 551
Query: 1145 YVKPL 1149
Y++ L
Sbjct: 552 YIELL 556
Score = 32.7 bits (73), Expect = 2.0
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 810 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 867
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 674 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 733
Query: 868 YIELL 872
Y++ L
Sbjct: 734 YVKPL 738
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 632 bits (1630), Expect = 0.0
Identities = 354/502 (70%), Positives = 357/502 (71%), Gaps = 140/502 (27%)
Query: 476 DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER 535
DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER
Sbjct: 244 DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER 303
Query: 536 NDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSE 595
NDWEPPDKKVDTRKYRAE
Sbjct: 304 NDWEPPDKKVDTRKYRAE------------------------------------------ 321
Query: 596 LEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANV 655
PK I++Y PG S+L TN EKM
Sbjct: 322 -------PKSIYEYQPGKSSVL------TN----------------EKM----------- 341
Query: 656 PQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPL 715
SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPL
Sbjct: 342 --SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPL 399
Query: 716 QGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEE 775
QGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 400 QGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR---------------------- 437
Query: 776 ADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELP 835
RRH DD EMRPARAKFDFKAQTLKELP
Sbjct: 438 -----RRH----------------------DD-------KEMRPARAKFDFKAQTLKELP 463
Query: 836 LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAI 895
LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAI
Sbjct: 464 LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAI 523
Query: 896 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN 955
AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN
Sbjct: 524 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN 583
Query: 956 PVDYMDLPFSSSPSRSATASPQ 977
PVDYMDLPFSSSPSRSATASPQ
Sbjct: 584 PVDYMDLPFSSSPSRSATASPQ 605
Score = 280 bits (717), Expect = 4e-75
Identities = 168/264 (63%), Positives = 188/264 (71%), Gaps = 20/264 (7%)
Query: 269 STDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 328
S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS
Sbjct: 105 SQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 164
Query: 329 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 388
DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT
Sbjct: 165 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 224
Query: 389 ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEETKSCSVMSPRLECSG 448
ERSKDWYKTMFKQIHKLNRD + + Y P Y F SE+TKS + PR +
Sbjct: 225 ERSKDWYKTMFKQIHKLNRD-DDSDLYSPRYSF---------SEDTKS-PLSVPRSKSEM 273
Query: 449 TVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTKSPLSVPRS-----KS 503
+ I + ++ P + S ++ + +D P DT+ + P+S
Sbjct: 274 SYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPP--DKKVDTRKYRAEPKSIYEYQPG 331
Query: 504 EMSYIDGEKVVKRSATLPLPARSS 527
+ S + EK+ SA P P SS
Sbjct: 332 KSSVLTNEKM--SSAISPTPEISS 353
Score = 197 bits (500), Expect = 6e-50
Identities = 117/194 (60%), Positives = 124/194 (63%), Gaps = 49/194 (25%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQD++ P + V L+ TD + P
Sbjct: 80 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS------PLLNEVSSSLIGTDSQAFPSVSKP 133
Query: 181 TPLGPLGCV--PTI 192
+ P + PTI
Sbjct: 134 SSAYPSTTIVNPTI 147
Score = 196 bits (498), Expect = 1e-49
Identities = 120/271 (44%), Positives = 146/271 (53%), Gaps = 39/271 (14%)
Query: 890 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 949
E A AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP TY++++
Sbjct: 444 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELLP 501
Query: 950 RPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSC 1009
P + + P + + E ++ + G +I
Sbjct: 502 ------PAE------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI----- 544
Query: 1010 LKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGE---------Q 1060
T R D N E PG FP + + +R
Sbjct: 545 -----------TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFS 593
Query: 1061 AGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 1120
+ + QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM
Sbjct: 594 SSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 653
Query: 1121 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 654 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 684
Score = 33.1 bits (74), Expect = 1.6
Identities = 18/65 (27%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 1085 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1144
R +++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 438 RRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 495
Query: 1145 YVKPL 1149
Y++ L
Sbjct: 496 YIELL 500
Score = 32.7 bits (73), Expect = 2.0
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 810 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 867
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 618 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 677
Query: 868 YIELL 872
Y++ L
Sbjct: 678 YVKPL 682
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 316 bits (810), Expect = 7e-86
Identities = 203/541 (37%), Positives = 289/541 (53%), Gaps = 108/541 (19%)
Query: 476 DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPAR 525
DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 158 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 217
Query: 526 SSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRD 576
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +
Sbjct: 218 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPTDR 277
Query: 577 ISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTE 636
I+P++IDL+NEPWYKFFSELEFG+PPPKK DY +D + + + SL Q+
Sbjct: 278 INPDDIDLENEPWYKFFSELEFGRPPPKKPLDYV---------QDHSSGVFNEASLYQSS 328
Query: 637 LEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTS 696
++ LE+ P SSA +S+F +R+S+ A G
Sbjct: 329 IDRSLER------------PMSSASM--------------ASDFRK-RRKSEPAVGPPRG 361
Query: 697 LENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRH 756
L ++ S G + L G S S ++S+ S S R
Sbjct: 362 LGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-------------------RA 399
Query: 757 DDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSE 816
D+E + R ++ + + ER G E
Sbjct: 400 KDRE------------------SPRSYSSTLTDMGRSAPRERRGT-----------PEKE 430
Query: 817 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 876
PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P E
Sbjct: 431 KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPE 490
Query: 877 KAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 935
KAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+
Sbjct: 491 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 550
Query: 936 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAG 995
RQGIFP++YV+V+K+ K DY D P S S S + + + + +G G
Sbjct: 551 RQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 609
Query: 996 E 996
E
Sbjct: 610 E 610
Score = 216 bits (550), Expect = 1e-55
Identities = 213/753 (28%), Positives = 316/753 (41%), Gaps = 155/753 (20%)
Query: 249 PPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVN 308
P + + R V P+L S T S +N S + S S SAY +N
Sbjct: 10 PDSAKGFRSV-RPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLN 66
Query: 309 PTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVK 368
+IV+ Q S S + D + P EKR V+K
Sbjct: 67 SSIVM-------QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIK 114
Query: 369 STQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELP 425
+ +DE GIP +R T +R KDWYKTMFKQIH +++ + + Y Y
Sbjct: 115 APHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPY------ 168
Query: 426 EIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPR 485
T + + +P S+P + SD SP
Sbjct: 169 --------TYNAGLYNPPYSA--------------QSHPAAKTQTYRPLSKSHSD-NSP- 204
Query: 486 YSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKV 545
+ +D SP+ P P+P +SS+E++DW+PPD+KV
Sbjct: 205 -NAFKDASSPVPPPH-----------------VPPPVPPLRPRDRSSTEKHDWDPPDRKV 246
Query: 546 DTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKK 605
DTRK+R+EP+SI+EY+PGKSS+L +E+ + I+P++IDL+NEPWYKFFSELEFG+PPPKK
Sbjct: 247 DTRKFRSEPRSIFEYEPGKSSILQHERPTDRINPDDIDLENEPWYKFFSELEFGRPPPKK 306
Query: 606 IWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTP 665
DY +D + + + SL Q+ ++ LE+ P SSA
Sbjct: 307 PLDYV---------QDHSSGVFNEASLYQSSIDRSLER------------PMSSA----- 340
Query: 666 EISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSV----LEGGDIPLQGLSGL 721
+S+F +R+S+ A G L ++ S L G L
Sbjct: 341 ---------SMASDFRK-RRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTS 390
Query: 722 KRPSSSASTKDSESPRHFIPA-DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA 780
PSS + KD ESPR + + + RR +KEKL A + Q +++
Sbjct: 391 SSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSF 450
Query: 781 RRHTGVI---PTHHQFITNERFG--DLLNIDDTAKRKSGSEMRPAR-------------- 821
++ V + E G + I K + +PAR
Sbjct: 451 KKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAI 510
Query: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELL------- 872
AK++F A T EL L+KGD V + K++DQNWYEG+ G R GIFP +Y+E++
Sbjct: 511 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 570
Query: 873 -----PP--------------AEKAQPKKLTPVQVLEYGEAI-AKFNFNGDTQVEMSFRK 912
PP + K Q T + GE A +N+ + E+ R+
Sbjct: 571 EDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRE 630
Query: 913 GERITLLRQVDENWYEGRIPGTSRQGIFPITYV 945
+ I ++ + D+ W+ G T G FP YV
Sbjct: 631 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 663
Score = 148 bits (373), Expect = 3e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 405 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 464
Query: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 465 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 499
Query: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
+ G G I+K + ++V L R+ D N E PG
Sbjct: 500 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 550
Query: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 551 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 610
Query: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 611 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 270 bits (690), Expect = 6e-72
Identities = 153/339 (45%), Positives = 197/339 (58%), Gaps = 43/339 (12%)
Query: 811 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 870
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 376 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 435
Query: 871 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 930
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 436 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 495
Query: 931 IPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKA 990
I GT RQGIFP +YV V + P ++ D LP +SP +A A
Sbjct: 496 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLP--TSPRLTAAA---------------- 537
Query: 991 ERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAE 1050
R P P + +S P D+ S + T E + LG+ P
Sbjct: 538 ---RSARHPSSPS-ALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHS 593
Query: 1051 QTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELE 1110
+ H G+ P Q TP Y+A+Y Y PQN+DELE
Sbjct: 594 RGPSH----------PLDLGTSSPNTSQIHWTP-----------YRAMYQYRPQNEDELE 632
Query: 1111 LRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
LR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 633 LREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
Score = 75.1 bits (183), Expect = 4e-13
Identities = 96/377 (25%), Positives = 157/377 (41%), Gaps = 65/377 (17%)
Query: 515 KRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMS 574
+R A P PA SSS +S W+ ++ P+S + Y+PG S +
Sbjct: 181 QRPAHRPGPATSSSGRS------WDHSEEL---------PRSTFNYRPGAFSTVLQPSNQ 225
Query: 575 RDISPEEID--LKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSL 632
E++D E W +F ELE G+ P K + D PG+ P + + L+++L+
Sbjct: 226 VLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVD-DPGE---KPSQPIEVLLERELAE 281
Query: 633 CQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNF-HAVKRESDGAP 691
EL+ DL +ET +P ++ A P P +SS++ HA
Sbjct: 282 LSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAG---PASAWSSSYPHA--------- 329
Query: 692 GDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKD-SESPRHFIPADYLESTEE 750
L + R + + G P G PS ST+D S S PA E +
Sbjct: 330 ---PYLGSARSLSPHKMADGGSPFLGRRDFVYPS---STRDPSASNGGGSPARREEKKRK 383
Query: 751 FIRRRHD-----DKEKLL--ADQRRLKREQEEADIAARRH--TGVIPTHHQFITNERFGD 801
R + D KE L D + +E ++ + H G+ P + + +
Sbjct: 384 AARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPAN--------YVE 435
Query: 802 LLNIDDTAK-----RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 856
+L D+ K E A A++ FK EL +KG+ + + +++++NWYEG
Sbjct: 436 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 495
Query: 857 --HHGRVGIFPRTYIEL 871
GR GIFP +Y+++
Sbjct: 496 ITGTGRQGIFPASYVQV 512
Score = 38.9 bits (89), Expect = 0.028
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 803 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 860
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 600 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 659
Query: 861 VGIFPRTYI 869
G FP Y+
Sbjct: 660 FGTFPGNYV 668
Score = 36.6 bits (83), Expect = 0.14
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 14/85 (16%)
Query: 1065 AARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 1124
A+ GGS + +++R + ++ F +QA Q+ EL L+ GDIV + ++ D
Sbjct: 367 ASNGGGSPARREEKKR------KAARLKFDFQA------QSPKELTLQKGDIVYIHKEVD 414
Query: 1125 DGWFVGTSRRTKQFGTFPGNYVKPL 1149
W G + G FP NYV+ L
Sbjct: 415 KNWLEG--EHHGRLGIFPANYVEVL 437
Score = 36.2 bits (82), Expect = 0.18
Identities = 23/68 (33%), Positives = 35/68 (51%), Gaps = 8/68 (11%)
Query: 360 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRD-----TPE 411
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+ D T E
Sbjct: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFE 168
Query: 412 ENPYFPTY 419
E P P +
Sbjct: 169 EPPRDPRH 176
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 270 bits (690), Expect = 6e-72
Identities = 153/339 (45%), Positives = 197/339 (58%), Gaps = 43/339 (12%)
Query: 811 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 870
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
Query: 871 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 930
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
Query: 931 IPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKA 990
I GT RQGIFP +YV V + P ++ D LP +SP +A A
Sbjct: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLP--TSPRLTAAA---------------- 195
Query: 991 ERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAE 1050
R P P + +S P D+ S + T E + LG+ P
Sbjct: 196 ---RSARHPSSPS-ALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHS 251
Query: 1051 QTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELE 1110
+ H G+ P Q TP Y+A+Y Y PQN+DELE
Sbjct: 252 RGPSH----------PLDLGTSSPNTSQIHWTP-----------YRAMYQYRPQNEDELE 290
Query: 1111 LRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
LR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 291 LREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
Score = 38.9 bits (89), Expect = 0.028
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 803 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 860
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 258 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 317
Query: 861 VGIFPRTYI 869
G FP Y+
Sbjct: 318 FGTFPGNYV 326
Score = 36.6 bits (83), Expect = 0.14
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 14/85 (16%)
Query: 1065 AARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 1124
A+ GGS + +++R + ++ F +QA Q+ EL L+ GDIV + ++ D
Sbjct: 25 ASNGGGSPARREEKKR------KAARLKFDFQA------QSPKELTLQKGDIVYIHKEVD 72
Query: 1125 DGWFVGTSRRTKQFGTFPGNYVKPL 1149
W G + G FP NYV+ L
Sbjct: 73 KNWLEG--EHHGRLGIFPANYVEVL 95
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 258 bits (660), Expect = 2e-68
Identities = 184/541 (34%), Positives = 264/541 (48%), Gaps = 136/541 (25%)
Query: 476 DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPAR 525
DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 181 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 240
Query: 526 SSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRD 576
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 241 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER---- 296
Query: 577 ISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTE 636
PPPKK DY +D + + + SL Q+
Sbjct: 297 ------------------------PPPKKPLDYV---------QDHSSGVFNEASLYQSS 323
Query: 637 LEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTS 696
++ LE+ P SSA +S+F +R+S+ A G
Sbjct: 324 IDRSLER------------PMSSASM--------------ASDFRK-RRKSEPAVGPPRG 356
Query: 697 LENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRH 756
L ++ S G + L G S S ++S+ S S R
Sbjct: 357 LGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-------------------RA 394
Query: 757 DDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSE 816
D+E + R ++ + + ER G E
Sbjct: 395 KDRE------------------SPRSYSSTLTDMGRSAPRERRGT-----------PEKE 425
Query: 817 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 876
PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P E
Sbjct: 426 KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPE 485
Query: 877 KAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 935
KAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+
Sbjct: 486 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 545
Query: 936 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAG 995
RQGIFP++YV+V+K+ K DY D P S S S + + + + +G G
Sbjct: 546 RQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 604
Query: 996 E 996
E
Sbjct: 605 E 605
Score = 158 bits (399), Expect = 3e-38
Identities = 192/745 (25%), Positives = 287/745 (38%), Gaps = 182/745 (24%)
Query: 257 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 316
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 40 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 94
Query: 317 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 376
Q S S + D + P EKR V+K+
Sbjct: 95 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 145
Query: 377 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEE 433
+DE GIP +R T +R KDWYKTMFKQIH +++ + + Y Y
Sbjct: 146 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPY-------------- 191
Query: 434 TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTK 493
T + + +P S+P + SD SP + +D
Sbjct: 192 TYNAGLYNPPYSA--------------QSHPAAKTQTYRPLSKSHSD-NSP--NAFKDAS 234
Query: 494 SPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE 553
SP+ P P+P +SS+E++DW+PPD+KVDTRK+R+E
Sbjct: 235 SPVPPPH-----------------VPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSE 277
Query: 554 PKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGD 613
P+SI+EY+PGKSS+L +E +PPPKK DY
Sbjct: 278 PRSIFEYEPGKSSILQHE----------------------------RPPPKKPLDYV--- 306
Query: 614 CSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPG 673
+D + + + SL Q+ ++ LE+ P SSA
Sbjct: 307 ------QDHSSGVFNEASLYQSSIDRSLER------------PMSSA------------- 335
Query: 674 YIYSSNFHAVKRESDGAPGDLTSLENERQIYKSV----LEGGDIPLQGLSGLKRPSSSAS 729
+S+F +R+S+ A G L ++ S L G L PSS +
Sbjct: 336 -SMASDFRK-RRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSR 393
Query: 730 TKDSESPRHFIPA-DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVI- 787
KD ESPR + + + RR +KEKL A + Q +++ ++ V
Sbjct: 394 AKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYI 453
Query: 788 --PTHHQFITNERFG--DLLNIDDTAKRKSGSEMRPAR--------------AKFDFKAQ 829
+ E G + I K + +PAR AK++F A
Sbjct: 454 LRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNAD 513
Query: 830 TLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELL------------PP- 874
T EL L+KGD V + K++DQNWYEG+ G R GIFP +Y+E++ PP
Sbjct: 514 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI 573
Query: 875 -------------AEKAQPKKLTPVQVLEYGEAI-AKFNFNGDTQVEMSFRKGERITLLR 920
+ K Q T + GE A +N+ + E+ R+ + I ++
Sbjct: 574 PHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVME 633
Query: 921 QVDENWYEGRIPGTSRQGIFPITYV 945
+ D+ W+ G T G FP YV
Sbjct: 634 KCDDGWFVGTSRRTKFFGTFPGNYV 658
Score = 148 bits (373), Expect = 3e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 400 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 459
Query: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 460 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 494
Query: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
+ G G I+K + ++V L R+ D N E PG
Sbjct: 495 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 545
Query: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 546 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 605
Query: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 606 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
Score = 36.2 bits (82), Expect = 0.18
Identities = 22/44 (50%), Positives = 27/44 (61%), Gaps = 5/44 (11%)
Query: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKS 146
P SA WR + + NG+A SSLAAKG+RSV PNL +S
Sbjct: 10 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRS 51
Score = 31.6 bits (70), Expect = 4.5
Identities = 14/56 (25%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 819 PARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR--VGIFPRTYIELL 872
P +A +++ + EL L++ D++ + ++ D W+ G G FP Y++ L
Sbjct: 606 PFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 253 bits (647), Expect = 6e-67
Identities = 188/560 (33%), Positives = 272/560 (48%), Gaps = 121/560 (21%)
Query: 476 DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPAR 525
DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 291 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 350
Query: 526 SSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRD 576
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+
Sbjct: 351 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSI--------- 401
Query: 577 ISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTE 636
L+ +PPP P + +PRE + L
Sbjct: 402 -------------------LQHERPPP------LPTTPTPVPREPGRKPLSSS------- 429
Query: 637 LEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTS 696
++ + +PS P+S A PTP SS P S K+ D +
Sbjct: 430 ------RLGEVTGSPSPP-PRSGA--PTP--SSRAPAL---SPTRPPKKPLDYVQDHSSG 475
Query: 697 LENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRH 756
+ NE +Y+S ++ L+RP SSAS +F +RR
Sbjct: 476 VFNEASLYQSSID---------RSLERPMSSASM-----------------ASDFRKRRK 509
Query: 757 DDKE----KLLADQRRLKREQEEADIAA------RRHTGVIPTHHQFITNERF-----GD 801
+ + L DQ + D+ + T P+ +
Sbjct: 510 SEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSST 569
Query: 802 LLNIDDTAKRKSGS----EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH 857
L ++ +A R+ E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEH
Sbjct: 570 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 629
Query: 858 HGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERI 916
HGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+
Sbjct: 630 HGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRV 689
Query: 917 TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP 976
LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S S
Sbjct: 690 ILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSL 748
Query: 977 QPWREESGQYERKAERGAGE 996
+ + + + +G GE
Sbjct: 749 SSNKPQRPVFTHENIQGGGE 768
Score = 154 bits (389), Expect = 5e-37
Identities = 174/672 (25%), Positives = 268/672 (39%), Gaps = 169/672 (25%)
Query: 358 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEE 412
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ +
Sbjct: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
Query: 413 NPYFPTYKFPELPEIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVA 472
+ Y Y T + + +P S+P
Sbjct: 295 DMYNTPY--------------TYNAGLYNPPYSA--------------QSHPAAKTQTYR 326
Query: 473 GTADDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS 532
+ SD SP + +D SP+ P P+P +SS
Sbjct: 327 PLSKSHSD-NSP--NAFKDASSPVPPPH-----------------VPPPVPPLRPRDRSS 366
Query: 533 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKF 592
+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ + + EP K
Sbjct: 367 TEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER-PPPLPTTPTPVPREPGRKP 425
Query: 593 FSELEFGK--------------------------PPPKKIWDYTPGDCSILPREDRKTNL 626
S G+ PPKK DY +D + +
Sbjct: 426 LSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYV---------QDHSSGV 476
Query: 627 DKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRE 686
+ SL Q+ ++ LE+ P SSA +S+F +R+
Sbjct: 477 FNEASLYQSSIDRSLER------------PMSSA--------------SMASDFRK-RRK 509
Query: 687 SDGAPGDLTSLENERQIYKSV----LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 742
S+ A G L ++ S L G L PSS + KD ESPR +
Sbjct: 510 SEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSST 569
Query: 743 -DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVI---PTHHQFITNER 798
+ + RR +KEKL A + Q +++ ++ V + E
Sbjct: 570 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 629
Query: 799 FG--DLLNIDDTAKRKSGSEMRPAR--------------AKFDFKAQTLKELPLQKGDIV 842
G + I K + +PAR AK++F A T EL L+KGD V
Sbjct: 630 HGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRV 689
Query: 843 YIYKQIDQNWYEGEHHG--RVGIFPRTYIELL------------PP-------------- 874
+ K++DQNWYEG+ G R GIFP +Y+E++ PP
Sbjct: 690 ILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLS 749
Query: 875 AEKAQPKKLTPVQVLEYGEAI-AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 933
+ K Q T + GE A +N+ + E+ R+ + I ++ + D+ W+ G
Sbjct: 750 SNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRR 809
Query: 934 TSRQGIFPITYV 945
T G FP YV
Sbjct: 810 TKFFGTFPGNYV 821
Score = 148 bits (373), Expect = 3e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 563 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 622
Query: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 623 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 657
Query: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
+ G G I+K + ++V L R+ D N E PG
Sbjct: 658 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 708
Query: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 709 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 768
Query: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 769 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 253 bits (647), Expect = 6e-67
Identities = 188/560 (33%), Positives = 272/560 (48%), Gaps = 121/560 (21%)
Query: 476 DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPAR 525
DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 198 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 257
Query: 526 SSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRD 576
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+
Sbjct: 258 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSI--------- 308
Query: 577 ISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTE 636
L+ +PPP P + +PRE + L
Sbjct: 309 -------------------LQHERPPP------LPTTPTPVPREPGRKPLSSS------- 336
Query: 637 LEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTS 696
++ + +PS P+S A PTP SS P S K+ D +
Sbjct: 337 ------RLGEVTGSPSPP-PRSGA--PTP--SSRAPAL---SPTRPPKKPLDYVQDHSSG 382
Query: 697 LENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRH 756
+ NE +Y+S ++ L+RP SSAS +F +RR
Sbjct: 383 VFNEASLYQSSID---------RSLERPMSSASM-----------------ASDFRKRRK 416
Query: 757 DDKE----KLLADQRRLKREQEEADIAA------RRHTGVIPTHHQFITNERF-----GD 801
+ + L DQ + D+ + T P+ +
Sbjct: 417 SEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSST 476
Query: 802 LLNIDDTAKRKSGS----EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH 857
L ++ +A R+ E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEH
Sbjct: 477 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 536
Query: 858 HGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERI 916
HGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+
Sbjct: 537 HGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRV 596
Query: 917 TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP 976
LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S S
Sbjct: 597 ILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSL 655
Query: 977 QPWREESGQYERKAERGAGE 996
+ + + + +G GE
Sbjct: 656 SSNKPQRPVFTHENIQGGGE 675
Score = 154 bits (390), Expect = 4e-37
Identities = 196/771 (25%), Positives = 294/771 (38%), Gaps = 181/771 (23%)
Query: 257 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 316
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 57 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 111
Query: 317 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 376
Q S S + D + P EKR V+K+
Sbjct: 112 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 162
Query: 377 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEE 433
+DE GIP +R T +R KDWYKTMFKQIH +++ + + Y Y
Sbjct: 163 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPY-------------- 208
Query: 434 TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTK 493
T + + +P S+P + SD SP + +D
Sbjct: 209 TYNAGLYNPPYSA--------------QSHPAAKTQTYRPLSKSHSD-NSP--NAFKDAS 251
Query: 494 SPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE 553
SP+ P P+P +SS+E++DW+PPD+KVDTRK+R+E
Sbjct: 252 SPVPPPH-----------------VPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSE 294
Query: 554 PKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK------------- 600
P+SI+EY+PGKSS+L +E+ + + EP K S G+
Sbjct: 295 PRSIFEYEPGKSSILQHER-PPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGA 353
Query: 601 -------------PPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETL 647
PPKK DY +D + + + SL Q+ ++ LE+
Sbjct: 354 PTPSSRAPALSPTRPPKKPLDYV---------QDHSSGVFNEASLYQSSIDRSLER---- 400
Query: 648 NKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSV 707
P SSA +S+F +R+S+ A G L ++ S
Sbjct: 401 --------PMSSA--------------SMASDFRK-RRKSEPAVGPPRGLGDQSASRTSP 437
Query: 708 ----LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA-DYLESTEEFIRRRHDDKEKL 762
L G L PSS + KD ESPR + + + RR +KEKL
Sbjct: 438 GRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL 497
Query: 763 LADQRRLKREQEEADIAARRHTGVI---PTHHQFITNERFG--DLLNIDDTAKRKSGSEM 817
A + Q +++ ++ V + E G + I K +
Sbjct: 498 PAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKA 557
Query: 818 RPAR--------------AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RV 861
+PAR AK++F A T EL L+KGD V + K++DQNWYEG+ G R
Sbjct: 558 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 617
Query: 862 GIFPRTYIELL------------PP--------------AEKAQPKKLTPVQVLEYGEAI 895
GIFP +Y+E++ PP + K Q T + GE
Sbjct: 618 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 677
Query: 896 -AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 945
A +N+ + E+ R+ + I ++ + D+ W+ G T G FP YV
Sbjct: 678 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 728
Score = 148 bits (373), Expect = 3e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 470 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 529
Query: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 530 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 564
Query: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
+ G G I+K + ++V L R+ D N E PG
Sbjct: 565 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 615
Query: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 616 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 675
Query: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 676 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
Score = 36.2 bits (82), Expect = 0.18
Identities = 22/44 (50%), Positives = 27/44 (61%), Gaps = 5/44 (11%)
Query: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKS 146
P SA WR + + NG+A SSLAAKG+RSV PNL +S
Sbjct: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRS 68
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 218 bits (556), Expect = 2e-56
Identities = 174/541 (32%), Positives = 246/541 (45%), Gaps = 155/541 (28%)
Query: 476 DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPAR 525
DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 31 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 90
Query: 526 SSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRD 576
+SS+E++DW+PPD+KVDTR
Sbjct: 91 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTR---------------------------- 122
Query: 577 ISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTE 636
KF SE P+ I++Y PG SIL E + SL Q+
Sbjct: 123 --------------KFRSE-------PRSIFEYEPGKSSILQHE-------RPASLYQSS 154
Query: 637 LEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTS 696
++ LE+ P SSA +S+F +R+S+ A G
Sbjct: 155 IDRSLER------------PMSSASM--------------ASDFRK-RRKSEPAVGPPRG 187
Query: 697 LENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRH 756
L ++ S G + L G S S ++S+ S S R
Sbjct: 188 LGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-------------------RA 225
Query: 757 DDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSE 816
D+E + R ++ + + ER G E
Sbjct: 226 KDRE------------------SPRSYSSTLTDMGRSAPRERRGT-----------PEKE 256
Query: 817 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 876
PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P E
Sbjct: 257 KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPE 316
Query: 877 KAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 935
KAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+
Sbjct: 317 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 376
Query: 936 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAG 995
RQGIFP++YV+V+K+ K DY D P S S S + + + + +G G
Sbjct: 377 RQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 435
Query: 996 E 996
E
Sbjct: 436 E 436
Score = 148 bits (373), Expect = 3e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 231 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 290
Query: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 291 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 325
Query: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
+ G G I+K + ++V L R+ D N E PG
Sbjct: 326 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 376
Query: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 377 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 436
Query: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 437 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
Score = 92.0 bits (227), Expect = 3e-18
Identities = 59/189 (31%), Positives = 89/189 (47%), Gaps = 48/189 (25%)
Query: 384 PLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEETKSCSVMSPR 443
PL+ +R KDWYKTMFKQIH +++ + + Y Y T + + +P
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPY--------------TYNAGLYNPP 51
Query: 444 LECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTKSPLSVPRSKS 503
S+P + SD SP + +D SP+ P
Sbjct: 52 YSA--------------QSHPAAKTQTYRPLSKSHSD-NSP--NAFKDASSPVPPPH--- 91
Query: 504 EMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 563
P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 92 --------------VPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 137
Query: 564 KSSVLTNEK 572
KSS+L +E+
Sbjct: 138 KSSILQHER 146
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 214 bits (545), Expect = 4e-55
Identities = 174/525 (33%), Positives = 236/525 (44%), Gaps = 144/525 (27%)
Query: 481 LYSPRYSFSE------DTKSPLSVPRS-KSEMSYIDGEKVVKRS-ATLPLPARSSSLKSS 532
LY+P YS T PLS S S ++ D V P+P +SS
Sbjct: 199 LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSS 258
Query: 533 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKF 592
+E++DW+PPD+KVDTR KF
Sbjct: 259 TEKHDWDPPDRKVDTR------------------------------------------KF 276
Query: 593 FSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPS 652
SE P+ I++Y PG SIL E + SL Q+ ++ LE+
Sbjct: 277 RSE-------PRSIFEYEPGKSSILQHE-------RPASLYQSSIDRSLER--------- 313
Query: 653 ANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGD 712
P SSA +S+F +R+S+ A G L ++ S G
Sbjct: 314 ---PMSSASM--------------ASDFRK-RRKSEPAVGPPRGLGDQSA---SRTSPGR 352
Query: 713 IPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKRE 772
+ L G S S ++S+ S S R D+E
Sbjct: 353 VDLPGSSTTLTKSFTSSSPSSPS-------------------RAKDRE------------ 381
Query: 773 QEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLK 832
+ R ++ + + ER G E PA+A +DFKAQT K
Sbjct: 382 ------SPRSYSSTLTDMGRSAPRERRGT-----------PEKEKLPAKAVYDFKAQTSK 424
Query: 833 ELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEY 891
EL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E
Sbjct: 425 ELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 484
Query: 892 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 951
GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+
Sbjct: 485 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 544
Query: 952 LVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGE 996
K DY D P S S S + + + + +G GE
Sbjct: 545 -TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 588
Score = 148 bits (373), Expect = 3e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 383 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 442
Query: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 443 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 477
Query: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
+ G G I+K + ++V L R+ D N E PG
Sbjct: 478 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 528
Query: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 529 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 588
Query: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 589 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
Score = 86.7 bits (213), Expect = 1e-16
Identities = 90/319 (28%), Positives = 125/319 (39%), Gaps = 80/319 (25%)
Query: 257 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 316
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 57 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 111
Query: 317 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 376
Q S S + D + P EKR V+K+
Sbjct: 112 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 162
Query: 377 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEE 433
+DE GIP +R T +R KDWYKTMFKQIH +++ Y P Y P + +
Sbjct: 163 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHK----PGLYNPPYSAQSHPAAKTQTYR 218
Query: 434 TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTK 493
S S S N P + +D
Sbjct: 219 PLSKS---------------------HSDNSPNA---------------------FKDAS 236
Query: 494 SPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE 553
SP+ P + PL R S S+E++DW+PPD+KVDTRK+R+E
Sbjct: 237 SPVPPPHVPPPVP--------------PLRPRDRS---STEKHDWDPPDRKVDTRKFRSE 279
Query: 554 PKSIYEYQPGKSSVLTNEK 572
P+SI+EY+PGKSS+L +E+
Sbjct: 280 PRSIFEYEPGKSSILQHER 298
Score = 36.2 bits (82), Expect = 0.18
Identities = 22/44 (50%), Positives = 27/44 (61%), Gaps = 5/44 (11%)
Query: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKS 146
P SA WR + + NG+A SSLAAKG+RSV PNL +S
Sbjct: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRS 68
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 201 bits (510), Expect = 4e-51
Identities = 101/182 (55%), Positives = 128/182 (70%), Gaps = 2/182 (1%)
Query: 816 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 875
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 768 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 827
Query: 876 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 934
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 828 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 887
Query: 935 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGA 994
+RQGIFP++YV+V+K+ K DY D P S S S + + + + +G
Sbjct: 888 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 946
Query: 995 GE 996
GE
Sbjct: 947 GE 948
Score = 148 bits (373), Expect = 3e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 743 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 802
Query: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 803 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 837
Query: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
+ G G I+K + ++V L R+ D N E PG
Sbjct: 838 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 888
Query: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 889 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 948
Query: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 949 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 84.3 bits (207), Expect = 6e-16
Identities = 59/189 (31%), Positives = 83/189 (43%), Gaps = 63/189 (33%)
Query: 384 PLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEETKSCSVMSPR 443
PL+ +R KDWYKTMFKQIH +++ Y P Y P + + S S
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHK----PGLYNPPYSAQSHPAAKTQTYRPLSKS----- 56
Query: 444 LECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTKSPLSVPRSKS 503
S N P + +D SP+ P
Sbjct: 57 ----------------HSDNSPNA---------------------FKDASSPVPPPHVPP 79
Query: 504 EMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 563
+ PL R S S+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 80 PVP--------------PLRPRDRS---STEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 122
Query: 564 KSSVLTNEK 572
KSS+L +E+
Sbjct: 123 KSSILQHER 131
Score = 42.4 bits (98), Expect = 0.003
Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 15/119 (12%)
Query: 1039 PLGSAFPGSEAEQTERH---RGGEQAGRKAARRGGSQ-----QPQAQQRRVTPDRSQTSQ 1090
P ++F + + H RGG R++ R S + ++RR TP++ +
Sbjct: 713 PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA 772
Query: 1091 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
+A+Y + Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 773 -----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 824
Score = 31.6 bits (70), Expect = 4.5
Identities = 14/56 (25%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 819 PARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR--VGIFPRTYIELL 872
P +A +++ + EL L++ D++ + ++ D W+ G G FP Y++ L
Sbjct: 949 PFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 201 bits (510), Expect = 4e-51
Identities = 101/182 (55%), Positives = 128/182 (70%), Gaps = 2/182 (1%)
Query: 816 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 875
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 864 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 923
Query: 876 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 934
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 924 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 983
Query: 935 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGA 994
+RQGIFP++YV+V+K+ K DY D P S S S + + + + +G
Sbjct: 984 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 1042
Query: 995 GE 996
GE
Sbjct: 1043 GE 1044
Score = 148 bits (373), Expect = 3e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 839 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 898
Query: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 899 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 933
Query: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
+ G G I+K + ++V L R+ D N E PG
Sbjct: 934 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 984
Query: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 985 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 1044
Query: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1045 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 94.0 bits (232), Expect = 7e-19
Identities = 68/220 (30%), Positives = 105/220 (47%), Gaps = 53/220 (24%)
Query: 358 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEE 412
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ +
Sbjct: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
Query: 413 NPYFPTYKFPELPEIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVA 472
+ Y Y T + + +P S+P
Sbjct: 116 DMYNTPY--------------TYNAGLYNPPYSA--------------QSHPAAKTQTYR 147
Query: 473 GTADDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSS 532
+ SD SP + +D SP+ P P+P +SS
Sbjct: 148 PLSKSHSD-NSP--NAFKDASSPVPPPH-----------------VPPPVPPLRPRDRSS 187
Query: 533 SERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEK 572
+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 188 TEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER 227
Score = 42.4 bits (98), Expect = 0.003
Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 15/119 (12%)
Query: 1039 PLGSAFPGSEAEQTERH---RGGEQAGRKAARRGGSQ-----QPQAQQRRVTPDRSQTSQ 1090
P ++F + + H RGG R++ R S + ++RR TP++ +
Sbjct: 809 PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA 868
Query: 1091 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
+A+Y + Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 869 -----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 920
Score = 31.6 bits (70), Expect = 4.5
Identities = 14/56 (25%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 819 PARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR--VGIFPRTYIELL 872
P +A +++ + EL L++ D++ + ++ D W+ G G FP Y++ L
Sbjct: 1045 PFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 139 bits (351), Expect = 1e-32
Identities = 108/351 (30%), Positives = 166/351 (47%), Gaps = 49/351 (13%)
Query: 821 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 880
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
Query: 881 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 938
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLG--DKIG 307
Query: 939 IFPITYVDVIKRPLVKNPVDYMDLPF--------SSSPSRS---ATASPQPWREESGQYE 987
IFP+ YV++ K ++ MD P +S PS S A+ +P P SG
Sbjct: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVS 364
Query: 988 RKAERGAGERGPGGPKISKK----SCLKPSDVVRCLSTEQRLSDLNTP-----EESRPGK 1038
A +R G K +KK + L + ++ + +++ P + R
Sbjct: 365 ------AFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAA 418
Query: 1039 PLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQAL 1098
+G S A T+ + A R S + + TP + Q ++ Y AL
Sbjct: 419 RIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGE----QGTPPKVQLPLNV--YLAL 472
Query: 1099 YSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
Y+Y PQ DELEL G++ V+EKC DGWF G S RT G FPGNYV P+
Sbjct: 473 YAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
Score = 59.3 bits (142), Expect = 2e-08
Identities = 25/53 (47%), Positives = 40/53 (75%)
Query: 1095 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
Y+ + SY PQ++ E+EL++GDIV V +K +DGW+ GT +R + G FPG++V+
Sbjct: 828 YRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 45.8 bits (107), Expect = 2e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 821 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 870
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 37.0 bits (84), Expect = 0.11
Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 872 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 930
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
Query: 931 IPGTSRQGIFPITYVDVIKR 950
T G+FP YV + R
Sbjct: 506 SLRTGVSGVFPGNYVTPVSR 525
Score = 33.1 bits (74), Expect = 1.6
Identities = 10/43 (23%), Positives = 28/43 (65%)
Query: 904 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 946
++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+
Sbjct: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 115 bits (288), Expect = 2e-25
Identities = 92/342 (26%), Positives = 155/342 (45%), Gaps = 42/342 (12%)
Query: 820 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 879
A+A +++ Q +L KGDI+ + +Q+D+NWY+GE +G G FP + +E++ + Q
Sbjct: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIK--QLPQ 187
Query: 880 PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 935
P L A+ F+ G + E ++F K + IT++ +VDENW EG++
Sbjct: 188 PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLG--D 237
Query: 936 RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYER 988
+ GIFPI +V+ ++++ + +L SS SR T++
Sbjct: 238 KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTST------------- 284
Query: 989 KAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSE 1048
RG G R + S + L + + + + + +++TP P P +
Sbjct: 285 -LRRGPGSRRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEK 343
Query: 1049 AEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDE 1108
A+ G+ + P V+ SQ + AL+SY DE
Sbjct: 344 ADVPS-----SCVGQVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDE 398
Query: 1109 LELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 1150
L+L+ G+ V V+ KC DGW G S T + G FP NYV P++
Sbjct: 399 LDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIF 440
Score = 33.9 bits (76), Expect = 0.92
Identities = 18/56 (32%), Positives = 28/56 (50%)
Query: 895 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 950
+A +++ E+ +KGE + +L + + W G T R GIFP YV I R
Sbjct: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFR 441
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 96.7 bits (239), Expect = 1e-19
Identities = 91/341 (26%), Positives = 139/341 (40%), Gaps = 50/341 (14%)
Query: 821 RAKFDFKAQTLKE----LPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 876
+A +DF+ + + LP K D++ + +++D+NW EG ++GIFP +Y+E A+
Sbjct: 202 KALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAK 261
Query: 877 KAQPKKLTPVQVLEYGE----AIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP 932
+ PV ++ GE A + + + +K T L ++
Sbjct: 262 QLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANK-------- 313
Query: 933 GTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAER 992
S Q +++ L+ + S S +A Q +G
Sbjct: 314 --SSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPP-- 369
Query: 993 GAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRP---GKPLGSAFPGSEA 1049
P P + S PSDV + L LN P P L S PG+ A
Sbjct: 370 ------PSSPVTTGPSFTFPSDV----PYQAALGTLNPPLPPPPLLAATVLASTPPGATA 419
Query: 1050 EQTERHRGGEQAGRKAARRGGSQQPQAQQR-RVTPDRSQTSQDLFSYQALYSYIPQNDDE 1108
AA G +P A ++ R QT + Y A+Y Y P+ +DE
Sbjct: 420 A--------------AAAAGMGPRPMAGSTDQIAHLRPQTRPSV--YVAIYPYTPRKEDE 463
Query: 1109 LELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
LELR G++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 464 LELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
Score = 81.3 bits (199), Expect = 5e-15
Identities = 49/167 (29%), Positives = 91/167 (54%), Gaps = 23/167 (13%)
Query: 820 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 879
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
Query: 880 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 935
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
Query: 936 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQ 977
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+
Sbjct: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPK 291
Score = 59.3 bits (142), Expect = 2e-08
Identities = 26/53 (49%), Positives = 40/53 (75%)
Query: 1095 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
++ + SY PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 834 HRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 45.4 bits (106), Expect = 3e-04
Identities = 58/255 (22%), Positives = 99/255 (38%), Gaps = 51/255 (20%)
Query: 631 SLCQTELEAD--------LEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHA 682
S+ LEA+ L + T + S+ SSA P + E G + + +
Sbjct: 668 SITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKKEKKGLLKLLSGAS 727
Query: 683 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 742
KR+ +P +LE E L ++PLQG G + P + P +
Sbjct: 728 TKRKPRVSPPASPTLEVE-------LGSAELPLQGAVGPELPPGGGHGRAGSCP---VDG 777
Query: 743 DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL 802
D +T Q R+ D A + P Q ++ G +
Sbjct: 778 DGPVTTAV---------AGAALAQDAFHRKASSLDSAVP----IAPPPRQACSS--LGPV 822
Query: 803 LNIDDTAKRKSGSEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG-- 855
LN E RP R + Q+ EL L++GDIV+++K+ + W++G
Sbjct: 823 LN-----------ESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTL 871
Query: 856 EHHGRVGIFPRTYIE 870
+ +G+ G+FP +++E
Sbjct: 872 QRNGKTGLFPGSFVE 886
Score = 38.9 bits (89), Expect = 0.028
Identities = 19/79 (24%), Positives = 36/79 (45%)
Query: 895 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 954
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
Query: 955 NPVDYMDLPFSSSPSRSAT 973
+ + + SR T
Sbjct: 511 ASQAKVPMSTAGQTSRGVT 529
Score = 35.4 bits (80), Expect = 0.31
Identities = 32/118 (27%), Positives = 51/118 (43%), Gaps = 8/118 (6%)
Query: 1035 RPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFS 1094
+PG GS + A +++ + + G QQP+ Q P R L
Sbjct: 82 KPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWS-PPVRG--IPQLPC 138
Query: 1095 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 1149
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
Score = 31.2 bits (69), Expect = 5.9
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 904 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 948
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 85.1 bits (209), Expect = 3e-16
Identities = 89/366 (24%), Positives = 146/366 (39%), Gaps = 73/366 (19%)
Query: 817 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---- 872
M A +FD++AQ EL + G+I+ ++ D W+EG+ +GR G+FP ++ +
Sbjct: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
Query: 873 ---PPAEKAQPKKLTPV---QVLEYGEAIAKFNFNGD---------------TQVEMSFR 911
P KA K L V L E I + N G+ E+ +
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
Query: 912 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRS 971
G+ I ++ +V+E W+EG + G + G+FP ++ + + + D S S R
Sbjct: 121 VGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFIKELSGESDELGIS-QDEQLSKSSLRE 177
Query: 972 ATASPQPWREESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTP 1031
T S + S K+E G + K + D+ + + R +
Sbjct: 178 TTGSESDGGDSS---STKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVE 234
Query: 1032 EESRP-GKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQ 1090
+ P K +G P + A TPD S+T
Sbjct: 235 NDFLPVEKTIGKKLPATTA--------------------------------TPDSSKTEM 262
Query: 1091 DLFS-----YQALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPG 1143
D + + ++ Y QNDDEL +++GDIV ++ K D GW+ G + G FP
Sbjct: 263 DSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPD 320
Query: 1144 NYVKPL 1149
N+VK L
Sbjct: 321 NFVKLL 326
Score = 55.1 bits (131), Expect = 4e-07
Identities = 29/67 (43%), Positives = 43/67 (64%), Gaps = 5/67 (7%)
Query: 824 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 878
F ++AQ EL +++GDIV + + ID W+EGE +GR G+FP +++LLPP E
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 335
Query: 879 QPKKLTP 885
+PKK P
Sbjct: 336 RPKKPPP 342
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 84.7 bits (208), Expect = 5e-16
Identities = 48/162 (29%), Positives = 84/162 (51%), Gaps = 15/162 (9%)
Query: 825 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 882
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 446 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 505
Query: 883 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 942
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 506 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 563
Query: 943 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
+V+ ++ D P S + S + +E+SG
Sbjct: 564 NFVEPVE-----------DYPTSGANVLSTKVPLKTKKEDSG 594
Score = 77.8 bits (190), Expect = 6e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 808 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 860
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 588 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 647
Query: 861 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 920
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 648 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 702
Query: 921 QVDENWYEGRIPGTSRQGIFPITYVDVIK 949
VD++W G + G S GIFP Y+ ++
Sbjct: 703 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 729
Score = 69.7 bits (169), Expect = 2e-11
Identities = 38/140 (27%), Positives = 69/140 (49%), Gaps = 18/140 (12%)
Query: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 873
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 578
Query: 874 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 925
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 579 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 638
Query: 926 WYEGRIPGTSRQGIFPITYV 945
W GR+ R+GIFP +V
Sbjct: 639 WCRGRL--QDREGIFPAVFV 656
Score = 53.9 bits (128), Expect = 9e-07
Identities = 52/209 (24%), Positives = 84/209 (40%), Gaps = 17/209 (8%)
Query: 952 LVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSCLK 1011
L PV+ +P P++ P P + + + R ++ R + KK
Sbjct: 287 LPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATR--RSNKKLPFNRSSSDMDLQKKQSNL 344
Query: 1012 PSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEA----EQTERH----RGGEQAGR 1063
+ + + S + D P +PG PL S + + +QTE + + GE GR
Sbjct: 345 ATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGR 404
Query: 1064 KAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQA-----LYSYIPQNDDELELRDGDIVD 1118
+ P + R P+ +Q A L+ + + D+L L G+IV
Sbjct: 405 VHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVY 464
Query: 1119 VMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
++EK D W+ G R Q G FP NYVK
Sbjct: 465 LLEKIDTDWYRGNCR--NQIGIFPANYVK 491
Score = 48.9 bits (115), Expect = 3e-05
Identities = 34/117 (29%), Positives = 59/117 (50%), Gaps = 8/117 (6%)
Query: 838 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 892
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
Query: 893 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 948
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI 493
Score = 43.9 bits (102), Expect = 9e-04
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 1096 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
+ALY + +N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 677 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 730
Score = 35.4 bits (80), Expect = 0.31
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 1097 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 84.7 bits (208), Expect = 5e-16
Identities = 48/162 (29%), Positives = 84/162 (51%), Gaps = 15/162 (9%)
Query: 825 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 882
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 482 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 541
Query: 883 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 942
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 542 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 599
Query: 943 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
+V+ ++ D P S + S + +E+SG
Sbjct: 600 NFVEPVE-----------DYPTSGANVLSTKVPLKTKKEDSG 630
Score = 77.8 bits (190), Expect = 6e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 808 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 860
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 624 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 683
Query: 861 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 920
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 684 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 738
Query: 921 QVDENWYEGRIPGTSRQGIFPITYVDVIK 949
VD++W G + G S GIFP Y+ ++
Sbjct: 739 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 765
Score = 69.7 bits (169), Expect = 2e-11
Identities = 38/140 (27%), Positives = 69/140 (49%), Gaps = 18/140 (12%)
Query: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 873
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 614
Query: 874 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 925
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 615 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 674
Query: 926 WYEGRIPGTSRQGIFPITYV 945
W GR+ R+GIFP +V
Sbjct: 675 WCRGRL--QDREGIFPAVFV 692
Score = 53.9 bits (128), Expect = 9e-07
Identities = 52/209 (24%), Positives = 84/209 (40%), Gaps = 17/209 (8%)
Query: 952 LVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSCLK 1011
L PV+ +P P++ P P + + + R ++ R + KK
Sbjct: 323 LPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATR--RSNKKLPFNRSSSDMDLQKKQSNL 380
Query: 1012 PSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEA----EQTERH----RGGEQAGR 1063
+ + + S + D P +PG PL S + + +QTE + + GE GR
Sbjct: 381 ATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGR 440
Query: 1064 KAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQA-----LYSYIPQNDDELELRDGDIVD 1118
+ P + R P+ +Q A L+ + + D+L L G+IV
Sbjct: 441 VHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVY 500
Query: 1119 VMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
++EK D W+ G R Q G FP NYVK
Sbjct: 501 LLEKIDTDWYRGNCR--NQIGIFPANYVK 527
Score = 48.9 bits (115), Expect = 3e-05
Identities = 34/117 (29%), Positives = 59/117 (50%), Gaps = 8/117 (6%)
Query: 838 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 892
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
Query: 893 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 948
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI 529
Score = 43.9 bits (102), Expect = 9e-04
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 1096 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
+ALY + +N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 713 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 766
Score = 35.4 bits (80), Expect = 0.31
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 1097 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 84.7 bits (208), Expect = 5e-16
Identities = 48/162 (29%), Positives = 84/162 (51%), Gaps = 15/162 (9%)
Query: 825 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 882
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 505 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 564
Query: 883 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 942
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 565 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 622
Query: 943 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
+V+ ++ D P S + S + +E+SG
Sbjct: 623 NFVEPVE-----------DYPTSGANVLSTKVPLKTKKEDSG 653
Score = 77.8 bits (190), Expect = 6e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 808 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 860
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 647 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 706
Query: 861 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 920
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 707 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 761
Query: 921 QVDENWYEGRIPGTSRQGIFPITYVDVIK 949
VD++W G + G S GIFP Y+ ++
Sbjct: 762 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 788
Score = 69.7 bits (169), Expect = 2e-11
Identities = 38/140 (27%), Positives = 69/140 (49%), Gaps = 18/140 (12%)
Query: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 873
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
Query: 874 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 925
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 697
Query: 926 WYEGRIPGTSRQGIFPITYV 945
W GR+ R+GIFP +V
Sbjct: 698 WCRGRL--QDREGIFPAVFV 715
Score = 54.3 bits (129), Expect = 7e-07
Identities = 39/133 (29%), Positives = 66/133 (49%), Gaps = 8/133 (6%)
Query: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKA 878
A D +Q EL ++GD++ + KQ + N+ E GE GRV + I L ++
Sbjct: 422 ANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRS 481
Query: 879 QPKKLTPVQV-LEYG--EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 935
+P + Q ++ G A+ +F + +++ GE + LL ++D +WY G +
Sbjct: 482 RPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RN 539
Query: 936 RQGIFPITYVDVI 948
+ GIFP YV VI
Sbjct: 540 QIGIFPANYVKVI 552
Score = 45.8 bits (107), Expect = 2e-04
Identities = 54/232 (23%), Positives = 86/232 (37%), Gaps = 40/232 (17%)
Query: 952 LVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSCLK 1011
L PV+ +P P++ P P + + + R ++ R + KK
Sbjct: 323 LPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATR--RSNKKLPFNRSSSDMDLQKKQSNL 380
Query: 1012 PSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAF-----------------PGSEA----- 1049
+ + + S + D P +PG PL S + PG +
Sbjct: 381 ATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGD 440
Query: 1050 -----EQTERH----RGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQA--- 1097
+QTE + + GE GR + P + R P+ +Q A
Sbjct: 441 VLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHA 500
Query: 1098 --LYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
L+ + + D+L L G+IV ++EK D W+ G R Q G FP NYVK
Sbjct: 501 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVK 550
Score = 43.9 bits (102), Expect = 9e-04
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 1096 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
+ALY + +N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 736 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 789
Score = 35.4 bits (80), Expect = 0.31
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 1097 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 628
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 77.4 bits (189), Expect = 7e-14
Identities = 88/338 (26%), Positives = 136/338 (40%), Gaps = 68/338 (20%)
Query: 820 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE--- 876
A+A + A+ L K DI+ + +Q +NW+ GE HG G FP++Y++++P +E
Sbjct: 876 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 934
Query: 877 -------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEG 929
A KK T E IA + ++ +++F +GE I L+ Q D W+ G
Sbjct: 935 EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTG 993
Query: 930 RIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERK 989
I R GIFP YV P D S S+S ++ +P
Sbjct: 994 SI--GDRSGIFPSNYV---------KPKDQESF---GSASKSGASNKKP---------EI 1030
Query: 990 AERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEA 1049
A+ + G ++S L P ++ L +++ G G +A
Sbjct: 1031 AQVTSAYVASGSEQLS----LAPGQLILIL------------KKNTSGWWQGEL----QA 1070
Query: 1050 EQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDEL 1109
+R +G A S+ R TP Q + A+Y Y N+DEL
Sbjct: 1071 RGKKRQKGWFPASHVKLLGPSSE-------RATPAFHPVCQVI----AMYDYAANNEDEL 1119
Query: 1110 ELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
G +++VM K D W+ G G FP NYVK
Sbjct: 1120 SFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVK 1155
Score = 66.6 bits (161), Expect = 1e-10
Identities = 40/145 (27%), Positives = 74/145 (51%), Gaps = 14/145 (9%)
Query: 808 TAKRKSGSEMRP--ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR----- 860
+A + S +P A+ + A ++L L G ++ I K+ W++GE R
Sbjct: 1017 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1076
Query: 861 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 920
G FP ++++LL P+ + PV + IA +++ + + E+SF KG+ I ++
Sbjct: 1077 KGWFPASHVKLLGPSSERATPAFHPVC-----QVIAMYDYAANNEDELSFSKGQLINVMN 1131
Query: 921 QVDENWYEGRIPGTSRQGIFPITYV 945
+ D +W++G I G + G+FP YV
Sbjct: 1132 KDDPDWWQGEINGVT--GLFPSNYV 1154
Score = 56.6 bits (135), Expect = 1e-07
Identities = 91/471 (19%), Positives = 169/471 (35%), Gaps = 130/471 (27%)
Query: 749 EEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDT 808
+E +R+ ++K+K L +++ ++ QEE A + + D L ++
Sbjct: 678 KENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-------------RKDKDTLKAEEK 724
Query: 809 AKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPR 866
KR++ S + RA + F+A+ E+ GDI+ + ++ + W G G G FP
Sbjct: 725 -KRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPC 783
Query: 867 TYIE----------------LLPPA----------------------------------- 875
Y+E LLPP
Sbjct: 784 NYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVN 843
Query: 876 ----------EKAQPKKLTPV----QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQ 921
P ++P+ QV+E +A A ++ ++F K + IT+L Q
Sbjct: 844 TSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ 903
Query: 922 VDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWRE 981
ENW+ G + G +G FP +YV +I VK P A
Sbjct: 904 -QENWWFGEVHGG--RGWFPKSYVKIIPGSEVKR----------EEPEALYAA------- 943
Query: 982 ESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLG 1041
+K A G + S ++P D+ E ++ + +
Sbjct: 944 ----VNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS 999
Query: 1042 SAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSY 1101
FP + + ++ G +A + G+ + + +VT +Y
Sbjct: 1000 GIFPSNYVKPKDQESFG------SASKSGASNKKPEIAQVTS----------------AY 1037
Query: 1102 IPQNDDELELRDGDIVDVMEKCDDGWFVGTSR---RTKQFGTFPGNYVKPL 1149
+ ++L L G ++ +++K GW+ G + + +Q G FP ++VK L
Sbjct: 1038 VASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1088
Score = 45.8 bits (107), Expect = 2e-04
Identities = 17/58 (29%), Positives = 34/58 (58%)
Query: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 879
A +D+ A EL KG ++ + + D +W++GE +G G+FP Y+++ ++ +Q
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1164
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 77.4 bits (189), Expect = 7e-14
Identities = 88/338 (26%), Positives = 136/338 (40%), Gaps = 68/338 (20%)
Query: 820 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE--- 876
A+A + A+ L K DI+ + +Q +NW+ GE HG G FP++Y++++P +E
Sbjct: 903 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 961
Query: 877 -------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEG 929
A KK T E IA + ++ +++F +GE I L+ Q D W+ G
Sbjct: 962 EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTG 1020
Query: 930 RIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERK 989
I R GIFP YV P D S S+S ++ +P
Sbjct: 1021 SI--GDRSGIFPSNYV---------KPKDQESF---GSASKSGASNKKP---------EI 1057
Query: 990 AERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEA 1049
A+ + G ++S L P ++ L +++ G G +A
Sbjct: 1058 AQVTSAYVASGSEQLS----LAPGQLILIL------------KKNTSGWWQGEL----QA 1097
Query: 1050 EQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDEL 1109
+R +G A S+ R TP Q + A+Y Y N+DEL
Sbjct: 1098 RGKKRQKGWFPASHVKLLGPSSE-------RATPAFHPVCQVI----AMYDYAANNEDEL 1146
Query: 1110 ELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
G +++VM K D W+ G G FP NYVK
Sbjct: 1147 SFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVK 1182
Score = 66.6 bits (161), Expect = 1e-10
Identities = 40/145 (27%), Positives = 74/145 (51%), Gaps = 14/145 (9%)
Query: 808 TAKRKSGSEMRP--ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR----- 860
+A + S +P A+ + A ++L L G ++ I K+ W++GE R
Sbjct: 1044 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1103
Query: 861 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 920
G FP ++++LL P+ + PV + IA +++ + + E+SF KG+ I ++
Sbjct: 1104 KGWFPASHVKLLGPSSERATPAFHPVC-----QVIAMYDYAANNEDELSFSKGQLINVMN 1158
Query: 921 QVDENWYEGRIPGTSRQGIFPITYV 945
+ D +W++G I G + G+FP YV
Sbjct: 1159 KDDPDWWQGEINGVT--GLFPSNYV 1181
Score = 56.6 bits (135), Expect = 1e-07
Identities = 91/471 (19%), Positives = 169/471 (35%), Gaps = 130/471 (27%)
Query: 749 EEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDT 808
+E +R+ ++K+K L +++ ++ QEE A + + D L ++
Sbjct: 705 KENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-------------RKDKDTLKAEEK 751
Query: 809 AKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPR 866
KR++ S + RA + F+A+ E+ GDI+ + ++ + W G G G FP
Sbjct: 752 -KRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPC 810
Query: 867 TYIE----------------LLPPA----------------------------------- 875
Y+E LLPP
Sbjct: 811 NYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVN 870
Query: 876 ----------EKAQPKKLTPV----QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQ 921
P ++P+ QV+E +A A ++ ++F K + IT+L Q
Sbjct: 871 TSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ 930
Query: 922 VDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWRE 981
ENW+ G + G +G FP +YV +I VK P A
Sbjct: 931 -QENWWFGEVHGG--RGWFPKSYVKIIPGSEVKR----------EEPEALYAA------- 970
Query: 982 ESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLG 1041
+K A G + S ++P D+ E ++ + +
Sbjct: 971 ----VNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS 1026
Query: 1042 SAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSY 1101
FP + + ++ G +A + G+ + + +VT +Y
Sbjct: 1027 GIFPSNYVKPKDQESFG------SASKSGASNKKPEIAQVTS----------------AY 1064
Query: 1102 IPQNDDELELRDGDIVDVMEKCDDGWFVGTSR---RTKQFGTFPGNYVKPL 1149
+ ++L L G ++ +++K GW+ G + + +Q G FP ++VK L
Sbjct: 1065 VASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1115
Score = 45.8 bits (107), Expect = 2e-04
Identities = 17/58 (29%), Positives = 34/58 (58%)
Query: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 879
A +D+ A EL KG ++ + + D +W++GE +G G+FP Y+++ ++ +Q
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 77.4 bits (189), Expect = 7e-14
Identities = 88/338 (26%), Positives = 136/338 (40%), Gaps = 68/338 (20%)
Query: 820 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE--- 876
A+A + A+ L K DI+ + +Q +NW+ GE HG G FP++Y++++P +E
Sbjct: 903 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 961
Query: 877 -------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEG 929
A KK T E IA + ++ +++F +GE I L+ Q D W+ G
Sbjct: 962 EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTG 1020
Query: 930 RIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERK 989
I R GIFP YV P D S S+S ++ +P
Sbjct: 1021 SI--GDRSGIFPSNYV---------KPKDQESF---GSASKSGASNKKP---------EI 1057
Query: 990 AERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEA 1049
A+ + G ++S L P ++ L +++ G G +A
Sbjct: 1058 AQVTSAYVASGSEQLS----LAPGQLILIL------------KKNTSGWWQGEL----QA 1097
Query: 1050 EQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDEL 1109
+R +G A S+ R TP Q + A+Y Y N+DEL
Sbjct: 1098 RGKKRQKGWFPASHVKLLGPSSE-------RATPAFHPVCQVI----AMYDYAANNEDEL 1146
Query: 1110 ELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
G +++VM K D W+ G G FP NYVK
Sbjct: 1147 SFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVK 1182
Score = 66.6 bits (161), Expect = 1e-10
Identities = 40/145 (27%), Positives = 74/145 (51%), Gaps = 14/145 (9%)
Query: 808 TAKRKSGSEMRP--ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR----- 860
+A + S +P A+ + A ++L L G ++ I K+ W++GE R
Sbjct: 1044 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1103
Query: 861 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 920
G FP ++++LL P+ + PV + IA +++ + + E+SF KG+ I ++
Sbjct: 1104 KGWFPASHVKLLGPSSERATPAFHPVC-----QVIAMYDYAANNEDELSFSKGQLINVMN 1158
Query: 921 QVDENWYEGRIPGTSRQGIFPITYV 945
+ D +W++G I G + G+FP YV
Sbjct: 1159 KDDPDWWQGEINGVT--GLFPSNYV 1181
Score = 56.6 bits (135), Expect = 1e-07
Identities = 91/471 (19%), Positives = 169/471 (35%), Gaps = 130/471 (27%)
Query: 749 EEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDT 808
+E +R+ ++K+K L +++ ++ QEE A + + D L ++
Sbjct: 705 KENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-------------RKDKDTLKAEEK 751
Query: 809 AKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPR 866
KR++ S + RA + F+A+ E+ GDI+ + ++ + W G G G FP
Sbjct: 752 -KRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPC 810
Query: 867 TYIE----------------LLPPA----------------------------------- 875
Y+E LLPP
Sbjct: 811 NYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVN 870
Query: 876 ----------EKAQPKKLTPV----QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQ 921
P ++P+ QV+E +A A ++ ++F K + IT+L Q
Sbjct: 871 TSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ 930
Query: 922 VDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWRE 981
ENW+ G + G +G FP +YV +I VK P A
Sbjct: 931 -QENWWFGEVHGG--RGWFPKSYVKIIPGSEVKR----------EEPEALYAA------- 970
Query: 982 ESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLG 1041
+K A G + S ++P D+ E ++ + +
Sbjct: 971 ----VNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS 1026
Query: 1042 SAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSY 1101
FP + + ++ G +A + G+ + + +VT +Y
Sbjct: 1027 GIFPSNYVKPKDQESFG------SASKSGASNKKPEIAQVTS----------------AY 1064
Query: 1102 IPQNDDELELRDGDIVDVMEKCDDGWFVGTSR---RTKQFGTFPGNYVKPL 1149
+ ++L L G ++ +++K GW+ G + + +Q G FP ++VK L
Sbjct: 1065 VASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1115
Score = 45.8 bits (107), Expect = 2e-04
Identities = 17/58 (29%), Positives = 34/58 (58%)
Query: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 879
A +D+ A EL KG ++ + + D +W++GE +G G+FP Y+++ ++ +Q
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 72.0 bits (175), Expect = 3e-12
Identities = 71/258 (27%), Positives = 104/258 (40%), Gaps = 35/258 (13%)
Query: 817 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 876
M ARA AQ +EL ++GD++ I + W+EGE GR GIFP ++ELL P
Sbjct: 147 MGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLR 206
Query: 877 KAQPKKL--------------TPVQVLEYGE----------AIAKFNFNGDTQVEMSFRK 912
TPV E G +A + F E+ F
Sbjct: 207 TVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEV 266
Query: 913 GERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSA 972
G++I +L +++ W EG + G R GIFP +V + V+ + M LP S +R
Sbjct: 267 GDKIRILATLEDGWLEGSLKG--RTGIFPYRFVKLCPDTRVE---ETMALPQEGSLARIP 321
Query: 973 TASPQPWREESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPE 1032
S G E++ E E IS+ P+ + L++E + +
Sbjct: 322 ETSLDCLENTLGVEEQRHETSDHEAEEPDCIISE----APTSPLGHLTSEYDTDRNSYQD 377
Query: 1033 ESRPGKPLGSAFPGSEAE 1050
E G P S PG E E
Sbjct: 378 EDTAGGPPRS--PGVEWE 393
Score = 48.5 bits (114), Expect = 4e-05
Identities = 67/333 (20%), Positives = 120/333 (36%), Gaps = 48/333 (14%)
Query: 821 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 880
RA FDF +ELPL GDI+ + +D+ W G+ G FP +++E++ +
Sbjct: 8 RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEG 67
Query: 881 KKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIF 940
++L + F + +G+ + L W +GR +R G F
Sbjct: 68 ERL----------FVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGAR-GFF 116
Query: 941 PITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPG 1000
P + V + SS SR W +S ++ R
Sbjct: 117 PSSCVREL---------------CLSSQSRQ-------WHSQSALFQIPEYSMGQARALM 154
Query: 1001 G--PKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGG 1058
G ++ ++ + DV+ + + E R G FP E R
Sbjct: 155 GLSAQLDEELDFREGDVITIIGVPEP-GWFEGELEGRRG-----IFPEGFVELLGPLRTV 208
Query: 1059 EQAGRKAARR----GGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 1114
+++ + G + + PD + + ALY + +EL+ G
Sbjct: 209 DESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGV-ALYRFQALEPNELDFEVG 267
Query: 1115 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
D + ++ +DGW G+ + + G FP +VK
Sbjct: 268 DKIRILATLEDGWLEGSLK--GRTGIFPYRFVK 298
Score = 36.2 bits (82), Expect = 0.18
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 1096 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
+AL Q D+EL+ R+GD++ ++ + GWF G + G FP +V+ L
Sbjct: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRR--GIFPEGFVELL 202
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 68.9 bits (167), Expect = 3e-11
Identities = 65/259 (25%), Positives = 98/259 (37%), Gaps = 49/259 (18%)
Query: 893 EAIAKFNFNGDTQVEMSFRKGERITLLRQ-VDENWYEGRIPGTSRQGIFPITYVDVIKRP 951
EAIAK++F E+SF++G+ + +L + D+NWY+ + G + G P Y+++
Sbjct: 2 EAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNG--KDGFIPKNYIEM---- 55
Query: 952 LVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYER-KAERGAGERGPGGPKISKKSCL 1010
P PW G+ R KAE ++ G + ++S
Sbjct: 56 -----------------------KPHPWF--FGKIPRAKAEEMLSKQRHDGAFLIRESES 90
Query: 1011 KPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGG 1070
P D + + + L S E + HR
Sbjct: 91 APGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHR-------------- 136
Query: 1071 SQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVG 1130
S Q+ D Q Q QAL+ + PQ D EL R GD + VM+ D W+ G
Sbjct: 137 STSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKG 196
Query: 1131 TSRRTKQFGTFPGNYVKPL 1149
Q G FP NYV P+
Sbjct: 197 ACH--GQTGMFPRNYVTPV 213
Score = 53.9 bits (128), Expect = 9e-07
Identities = 25/55 (45%), Positives = 37/55 (67%), Gaps = 1/55 (1%)
Query: 820 ARAKFDFKAQTLKELPLQKGDIVYIY-KQIDQNWYEGEHHGRVGIFPRTYIELLP 873
A AK+DFKA EL ++GDI+ + ++ DQNWY+ E +G+ G P+ YIE+ P
Sbjct: 3 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKP 57
Score = 50.8 bits (120), Expect = 7e-06
Identities = 20/49 (40%), Positives = 31/49 (63%)
Query: 821 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYI 869
+A FDF Q EL ++GD +++ D NW++G HG+ G+FPR Y+
Sbjct: 162 QALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 210
Score = 38.9 bits (89), Expect = 0.028
Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 2/55 (3%)
Query: 896 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 950
A F+F+ E+ FR+G+ I ++ D NW++G G + G+FP YV + R
Sbjct: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHG--QTGMFPRNYVTPVNR 215
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 65.5 bits (158), Expect = 3e-10
Identities = 67/279 (24%), Positives = 114/279 (40%), Gaps = 53/279 (18%)
Query: 818 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---PP 874
R + F + + EL LQ G+IV + K+I+ W+ G+ +G++G FP ++ELL PP
Sbjct: 86 RWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145
Query: 875 A-----------EKAQPKKLTP---------VQVLEYGEAI-AKFNFNGDTQVEMSFRKG 913
+ +P KL+ +Q + + E F++ + E++ R+G
Sbjct: 146 SLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRG 205
Query: 914 ERITLLRQV--DENWYEGRIPGTSRQGIFPITYV------------DVIKRPL--VKNPV 957
+ + +L + D+ W+EG G R+G+FP +V V+ R +K P
Sbjct: 206 DVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFVLPPPPIKKLVPRKVVSRESAPIKEPK 263
Query: 958 DYMDLPFSSSPSRSATASPQP-----WREESGQYERKAERGAGERG---PGG---PKISK 1006
M + + ATA+ P R S ++ R +G G GG P +
Sbjct: 264 KLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKR 323
Query: 1007 KSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFP 1045
P E+ S + P R P +A P
Sbjct: 324 SKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATP 362
Score = 54.3 bits (129), Expect = 7e-07
Identities = 38/159 (23%), Positives = 73/159 (45%), Gaps = 20/159 (12%)
Query: 826 FKAQTLKELPLQKGDIVYIYKQID-QNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLT 884
++AQ EL L GD+V + + + W GE GR G+FP ++ +P + +
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 885 PVQVLEYGEAI----------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 934
P G F+++ + E+ + GE + +++++++ W+ G+ G
Sbjct: 69 PRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG- 127
Query: 935 SRQGIFPITYVDVIKR--PLVKNPVDYMDLP-FSSSPSR 970
+ G FP +V+++ P + NP D+P S P R
Sbjct: 128 -QLGAFPSNFVELLDSGPPSLGNP----DMPSVSPGPQR 161
Score = 53.9 bits (128), Expect = 9e-07
Identities = 27/81 (33%), Positives = 50/81 (61%), Gaps = 4/81 (4%)
Query: 1069 GGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWF 1128
G +++P+ +RR P + Q +SY P+ DEL+L+ G+IV+++++ +DGW+
Sbjct: 64 GEARRPRCARRRGHPAKHPRPQRWCKVN--FSYSPEQADELKLQAGEIVEMIKEIEDGWW 121
Query: 1129 VGTSRRTKQFGTFPGNYVKPL 1149
+G ++ Q G FP N+V+ L
Sbjct: 122 LG--KKNGQLGAFPSNFVELL 140
Score = 49.7 bits (117), Expect = 2e-05
Identities = 28/68 (41%), Positives = 37/68 (54%), Gaps = 4/68 (5%)
Query: 1083 PDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKC--DDGWFVGTSRRTKQFGT 1140
PD QT Y+ L+ Y P+ DEL LR GD+V V+ K D GW+ G + + G
Sbjct: 174 PDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GV 231
Query: 1141 FPGNYVKP 1148
FP N+V P
Sbjct: 232 FPDNFVLP 239
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.129 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,637,193
Number of Sequences: 37866
Number of extensions: 2812976
Number of successful extensions: 18155
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 269
Number of HSP's successfully gapped in prelim test: 689
Number of HSP's that attempted gapping in prelim test: 13997
Number of HSP's gapped (non-prelim): 3663
length of query: 1151
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1038
effective length of database: 13,968,660
effective search space: 14499469080
effective search space used: 14499469080
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.