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Search of human proteins with 76880480
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
(811 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 1635 0.0
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 184 3e-46
gi|198041768 synleurin [Homo sapiens] 166 1e-40
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 165 1e-40
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 165 1e-40
gi|225579152 insulin-like growth factor binding protein, acid la... 159 1e-38
gi|4826772 insulin-like growth factor binding protein, acid labi... 159 1e-38
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 138 2e-32
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 138 2e-32
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 137 4e-32
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 136 9e-32
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 134 3e-31
gi|12007646 nyctalopin precursor [Homo sapiens] 134 4e-31
gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo... 133 6e-31
gi|4759146 slit homolog 2 [Homo sapiens] 133 8e-31
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 131 2e-30
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 131 2e-30
gi|88702793 slit-like 2 [Homo sapiens] 131 3e-30
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 130 6e-30
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 127 4e-29
gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 126 7e-29
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 125 2e-28
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo... 124 3e-28
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 124 5e-28
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 123 6e-28
gi|194440719 chondroadherin-like [Homo sapiens] 122 1e-27
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 121 2e-27
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 121 2e-27
gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo s... 121 2e-27
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ... 121 3e-27
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 1635 bits (4235), Expect = 0.0
Identities = 811/811 (100%), Positives = 811/811 (100%)
Query: 1 MEAARALRLLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHD 60
MEAARALRLLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHD
Sbjct: 1 MEAARALRLLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHD 60
Query: 61 VLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQ 120
VLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQ
Sbjct: 61 VLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQ 120
Query: 121 ALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGN 180
ALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGN
Sbjct: 121 ALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGN 180
Query: 181 LLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANN 240
LLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANN
Sbjct: 181 LLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANN 240
Query: 241 LQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPL 300
LQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPL
Sbjct: 241 LQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPL 300
Query: 301 HSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNG 360
HSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNG
Sbjct: 301 HSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNG 360
Query: 361 WTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQNGSCADPSPS 420
WTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQNGSCADPSPS
Sbjct: 361 WTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQNGSCADPSPS 420
Query: 421 ASLTADRRRQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRFLAGVAWDGAARELVGNRS 480
ASLTADRRRQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRFLAGVAWDGAARELVGNRS
Sbjct: 421 ASLTADRRRQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRFLAGVAWDGAARELVGNRS 480
Query: 481 ALRLSRRGPGLQQPSPSVAAAAGPAPQSLDLHKKPQRGRPTRADPALAEPTPTASPGSAP 540
ALRLSRRGPGLQQPSPSVAAAAGPAPQSLDLHKKPQRGRPTRADPALAEPTPTASPGSAP
Sbjct: 481 ALRLSRRGPGLQQPSPSVAAAAGPAPQSLDLHKKPQRGRPTRADPALAEPTPTASPGSAP 540
Query: 541 SPAGDPWQRATKHRLGTEHQERAAQSDGGAGLPPLVSDPCDFNKFILCNLTVEAVGADSA 600
SPAGDPWQRATKHRLGTEHQERAAQSDGGAGLPPLVSDPCDFNKFILCNLTVEAVGADSA
Sbjct: 541 SPAGDPWQRATKHRLGTEHQERAAQSDGGAGLPPLVSDPCDFNKFILCNLTVEAVGADSA 600
Query: 601 SVRWAVREHRSPRPLGGARFRLLFDRFGQQPKFHRFVYLPESSDSATLRELRGDTPYLVC 660
SVRWAVREHRSPRPLGGARFRLLFDRFGQQPKFHRFVYLPESSDSATLRELRGDTPYLVC
Sbjct: 601 SVRWAVREHRSPRPLGGARFRLLFDRFGQQPKFHRFVYLPESSDSATLRELRGDTPYLVC 660
Query: 661 VEGVLGGRVCPVAPRDHCAGLVTLPEAGSRGGVDYQLLTLALLTVNALLVLLALAAWASR 720
VEGVLGGRVCPVAPRDHCAGLVTLPEAGSRGGVDYQLLTLALLTVNALLVLLALAAWASR
Sbjct: 661 VEGVLGGRVCPVAPRDHCAGLVTLPEAGSRGGVDYQLLTLALLTVNALLVLLALAAWASR 720
Query: 721 WLRRKLRARRKGGAPVHVRHMYSTRRPLRSMGTGVSADFSGFQSHRPRTTVCALSEADLI 780
WLRRKLRARRKGGAPVHVRHMYSTRRPLRSMGTGVSADFSGFQSHRPRTTVCALSEADLI
Sbjct: 721 WLRRKLRARRKGGAPVHVRHMYSTRRPLRSMGTGVSADFSGFQSHRPRTTVCALSEADLI 780
Query: 781 EFPCDRFMDSAGGGAGGSLRREDRLLQRFAD 811
EFPCDRFMDSAGGGAGGSLRREDRLLQRFAD
Sbjct: 781 EFPCDRFMDSAGGGAGGSLRREDRLLQRFAD 811
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 184 bits (467), Expect = 3e-46
Identities = 128/342 (37%), Positives = 172/342 (50%), Gaps = 4/342 (1%)
Query: 68 GNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTL 127
G+ N++ F L L +L L +N + +L F+ L+ LE L+L N LQAL
Sbjct: 106 GSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLF 165
Query: 128 APLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLE 187
PL L+ L N +++L F L SL L+L NAL LP VF LG+L L L+
Sbjct: 166 QPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLD 225
Query: 188 SNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPR 247
SN I L F+QL L L L N + + + FA L +L+ L L N L+ L
Sbjct: 226 SNNISELPPQVFSQLFCLERLWLQRNAI--THLPLSIFASLGNLTFLSLQWNMLRVLPAG 283
Query: 248 IFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALD 307
+F H P L LSL NQL +A F L LR L L N ++ LP + L L L
Sbjct: 284 LFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLY 343
Query: 308 LSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRL 367
L N L+ALHPA F +L +L LSL N L+ L IF + L+ L L GN W CDC L
Sbjct: 344 LGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHL 403
Query: 368 RGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQL 409
L W+ + RLL + C P L+G+ + L+++QL
Sbjct: 404 AYLFNWLQQY--TDRLLNIQTYCAGPAYLKGQVVPALNEKQL 443
Score = 83.6 bits (205), Expect = 7e-16
Identities = 59/180 (32%), Positives = 85/180 (47%), Gaps = 5/180 (2%)
Query: 180 NLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSAN 239
N++++ + + L K+ FLN + +P F L L L ++ +
Sbjct: 53 NIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPD-----AFGGLPRLEDLEVTGS 107
Query: 240 NLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEP 299
+ +L IF +L LG L+L N L L F L AL L L+GN+L LP L +P
Sbjct: 108 SFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQP 167
Query: 300 LHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
L L+ L+L+ N L+ L F L L+ L L NNALS L +F +L L LD N
Sbjct: 168 LTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSN 227
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 166 bits (419), Expect = 1e-40
Identities = 126/402 (31%), Positives = 193/402 (48%), Gaps = 15/402 (3%)
Query: 7 LRLLLVVCGCLALPPLAEPV--CPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTY 64
LRL LVV C L L + + C C + + C N GL +PK P +
Sbjct: 11 LRLFLVVT-CYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNF----PESTVFL 65
Query: 65 SLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAP 124
L GN I+ I + L L L L + I ++PK F +L L L+L NN ++ L P
Sbjct: 66 YLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDP 125
Query: 125 GTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYL 184
G L LR LY N++S + RG F L S+ L L N L L F + L L
Sbjct: 126 GIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRIL 185
Query: 185 HLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHL 244
L +N I + ++ F L L L L +N L +A F L+SL L LS N ++ +
Sbjct: 186 DLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNA--FEVLKSLRRLSLSHNPIEAI 243
Query: 245 GPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLE 304
P F+ L L L L+ +++ ++ + F G+ L+ L L N L L + L +L
Sbjct: 244 QPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLI 303
Query: 305 ALDLSGNELSALHPATFGHLG-RLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTC 363
L L N + ++ TF ++G L+ L+L N L+AL + +L L + N W C
Sbjct: 304 YLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWEC 363
Query: 364 DCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLD 405
+C+L GL+ W+ +T+ + C++PP++RG+ L Y++
Sbjct: 364 NCKLLGLRDWLA-----SSAITLNIYCQNPPSMRGRALRYIN 400
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 165 bits (418), Expect = 1e-40
Identities = 125/373 (33%), Positives = 171/373 (45%), Gaps = 27/373 (7%)
Query: 10 LLVVCGCLALPP-LAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLP------------ 56
LL++ GC A LA CP C C + CT G R+V + LP
Sbjct: 13 LLLLVGCQAWGAGLAYHGCPSECTCSRASQVECT--GARIVAVPTPLPWNAMSLQILNTH 70
Query: 57 ------SPH----DVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKL 106
SP ++ + N ++ IT F LG LR L L N+++ L F+ L
Sbjct: 71 ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGL 130
Query: 107 SRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNA 166
LE L L +N L + P + L+ L +GN + + G+F+ L L KL L N+
Sbjct: 131 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 190
Query: 167 LGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFA 226
L + VF LGNL L L NR+ + F L L+ L L N++ L F
Sbjct: 191 LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI--GLLSPGLFH 248
Query: 227 PLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEG 286
+L L LS N++ L P IF LP+L L+L GN L L+ F + LREL L
Sbjct: 249 NNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD 308
Query: 287 NRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFA 346
N +S LP + L L+ L LS N++S + P F L LRELSL NAL L G++F
Sbjct: 309 NHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFR 368
Query: 347 ASPALYRLDLDGN 359
L + L N
Sbjct: 369 MLANLQNISLQNN 381
Score = 88.2 bits (217), Expect = 3e-17
Identities = 56/158 (35%), Positives = 85/158 (53%)
Query: 59 HDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNL 118
H++ L N I+ + F +L QL RL L N ++ L F + L EL+L +N
Sbjct: 251 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 310
Query: 119 LQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPL 178
+ +L + LR+L++L + N+IS +S G+F GL L +L L NAL L VF L
Sbjct: 311 ISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRML 370
Query: 179 GNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQ 216
NL + L++NR+R L N FA + L + L N+L+
Sbjct: 371 ANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLE 408
Score = 70.1 bits (170), Expect = 8e-12
Identities = 47/136 (34%), Positives = 68/136 (50%), Gaps = 1/136 (0%)
Query: 227 PLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEG 286
P ++S IL+ + + L F ++ L L + N+L+ + P AF L +LR L L
Sbjct: 58 PWNAMSLQILNTH-ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLAN 116
Query: 287 NRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFA 346
N+L LP L + L SLE+L LS N+L + PA F L+EL L N L + F
Sbjct: 117 NKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFD 176
Query: 347 ASPALYRLDLDGNGWT 362
L +L+L N T
Sbjct: 177 HLVGLTKLNLGKNSLT 192
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 165 bits (418), Expect = 1e-40
Identities = 125/373 (33%), Positives = 171/373 (45%), Gaps = 27/373 (7%)
Query: 10 LLVVCGCLALPP-LAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLP------------ 56
LL++ GC A LA CP C C + CT G R+V + LP
Sbjct: 7 LLLLVGCQAWGAGLAYHGCPSECTCSRASQVECT--GARIVAVPTPLPWNAMSLQILNTH 64
Query: 57 ------SPH----DVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKL 106
SP ++ + N ++ IT F LG LR L L N+++ L F+ L
Sbjct: 65 ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGL 124
Query: 107 SRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNA 166
LE L L +N L + P + L+ L +GN + + G+F+ L L KL L N+
Sbjct: 125 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 184
Query: 167 LGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFA 226
L + VF LGNL L L NR+ + F L L+ L L N++ L F
Sbjct: 185 LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI--GLLSPGLFH 242
Query: 227 PLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEG 286
+L L LS N++ L P IF LP+L L+L GN L L+ F + LREL L
Sbjct: 243 NNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD 302
Query: 287 NRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFA 346
N +S LP + L L+ L LS N++S + P F L LRELSL NAL L G++F
Sbjct: 303 NHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFR 362
Query: 347 ASPALYRLDLDGN 359
L + L N
Sbjct: 363 MLANLQNISLQNN 375
Score = 88.2 bits (217), Expect = 3e-17
Identities = 56/158 (35%), Positives = 85/158 (53%)
Query: 59 HDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNL 118
H++ L N I+ + F +L QL RL L N ++ L F + L EL+L +N
Sbjct: 245 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 304
Query: 119 LQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPL 178
+ +L + LR+L++L + N+IS +S G+F GL L +L L NAL L VF L
Sbjct: 305 ISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRML 364
Query: 179 GNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQ 216
NL + L++NR+R L N FA + L + L N+L+
Sbjct: 365 ANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLE 402
Score = 70.1 bits (170), Expect = 8e-12
Identities = 47/136 (34%), Positives = 68/136 (50%), Gaps = 1/136 (0%)
Query: 227 PLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEG 286
P ++S IL+ + + L F ++ L L + N+L+ + P AF L +LR L L
Sbjct: 52 PWNAMSLQILNTH-ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLAN 110
Query: 287 NRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFA 346
N+L LP L + L SLE+L LS N+L + PA F L+EL L N L + F
Sbjct: 111 NKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFD 170
Query: 347 ASPALYRLDLDGNGWT 362
L +L+L N T
Sbjct: 171 HLVGLTKLNLGKNSLT 186
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 159 bits (401), Expect = 1e-38
Identities = 119/340 (35%), Positives = 162/340 (47%), Gaps = 11/340 (3%)
Query: 25 PVCPERCDCQHPQH-----LLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDF 79
P CP C C + + C++R L +P +P L L GN ++++ F
Sbjct: 77 PACPAACVCSYDDDADELSVFCSSRNLTRLP--DGVPGGTQALW--LDGNNLSSVPPAAF 132
Query: 80 HRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYAN 139
L L L+LQ Q+ SL P+ L L L+L N L++LA GT A L L +
Sbjct: 133 QNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLS 192
Query: 140 GNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAF 199
N +SRL G FEGL SL L L N+L LPDA F LG+L L L NR+ +L F
Sbjct: 193 NNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALF 252
Query: 200 AQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLS 259
+ L +LR L+LS N L+ A F L L L L N + + P F L L L
Sbjct: 253 SGLAELRELDLSRNALRAI--KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 310
Query: 260 LRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPA 319
L N++ L + F GL LR LRL N ++ L + LH LE L L N + L
Sbjct: 311 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 370
Query: 320 TFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
+F LG+L L+L +N L + F + ++L GN
Sbjct: 371 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 410
Score = 157 bits (396), Expect = 5e-38
Identities = 114/306 (37%), Positives = 148/306 (48%), Gaps = 30/306 (9%)
Query: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
L N + + F L LR L L +N I SL P+TF+ L LEEL LG+N ++ LA
Sbjct: 311 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 370
Query: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185
+ L +L +L + N++ + G+F GL ++ + L GN L LP+ VF LG L LH
Sbjct: 371 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLH 430
Query: 186 LESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLG 245
LE + LG++R TF L L L L N L +
Sbjct: 431 LEG-----------SCLGRIR---------------PHTFTGLSGLRRLFLKDNGLVGIE 464
Query: 246 PRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEA 305
+ L L L L NQLTHL F GL L L L NRL++LP L PL
Sbjct: 465 EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW 524
Query: 306 LDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDC 365
LD+S N L AL + LGRLR LSLRNN+L + P L RL L+GN W C C
Sbjct: 525 LDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT----PQPPGLERLWLEGNPWDCGC 580
Query: 366 RLRGLK 371
L+ L+
Sbjct: 581 PLKALR 586
Score = 80.1 bits (196), Expect = 8e-15
Identities = 52/157 (33%), Positives = 78/157 (49%)
Query: 60 DVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLL 119
+V +L GN + N+ F LG+L L L+ + + + P TF LS L L+L +N L
Sbjct: 401 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 460
Query: 120 QALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLG 179
+ +L L +L L N+++ L F+GL L L L N L LP PL
Sbjct: 461 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 520
Query: 180 NLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQ 216
+L + NR+ L + A LG+LR+L+L N L+
Sbjct: 521 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR 557
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 159 bits (401), Expect = 1e-38
Identities = 119/340 (35%), Positives = 162/340 (47%), Gaps = 11/340 (3%)
Query: 25 PVCPERCDCQHPQH-----LLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDF 79
P CP C C + + C++R L +P +P L L GN ++++ F
Sbjct: 39 PACPAACVCSYDDDADELSVFCSSRNLTRLP--DGVPGGTQALW--LDGNNLSSVPPAAF 94
Query: 80 HRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYAN 139
L L L+LQ Q+ SL P+ L L L+L N L++LA GT A L L +
Sbjct: 95 QNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLS 154
Query: 140 GNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAF 199
N +SRL G FEGL SL L L N+L LPDA F LG+L L L NR+ +L F
Sbjct: 155 NNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALF 214
Query: 200 AQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLS 259
+ L +LR L+LS N L+ A F L L L L N + + P F L L L
Sbjct: 215 SGLAELRELDLSRNALRAI--KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 272
Query: 260 LRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPA 319
L N++ L + F GL LR LRL N ++ L + LH LE L L N + L
Sbjct: 273 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 332
Query: 320 TFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
+F LG+L L+L +N L + F + ++L GN
Sbjct: 333 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372
Score = 157 bits (396), Expect = 5e-38
Identities = 114/306 (37%), Positives = 148/306 (48%), Gaps = 30/306 (9%)
Query: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
L N + + F L LR L L +N I SL P+TF+ L LEEL LG+N ++ LA
Sbjct: 273 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 332
Query: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185
+ L +L +L + N++ + G+F GL ++ + L GN L LP+ VF LG L LH
Sbjct: 333 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLH 392
Query: 186 LESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLG 245
LE + LG++R TF L L L L N L +
Sbjct: 393 LEG-----------SCLGRIR---------------PHTFTGLSGLRRLFLKDNGLVGIE 426
Query: 246 PRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEA 305
+ L L L L NQLTHL F GL L L L NRL++LP L PL
Sbjct: 427 EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW 486
Query: 306 LDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDC 365
LD+S N L AL + LGRLR LSLRNN+L + P L RL L+GN W C C
Sbjct: 487 LDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT----PQPPGLERLWLEGNPWDCGC 542
Query: 366 RLRGLK 371
L+ L+
Sbjct: 543 PLKALR 548
Score = 80.1 bits (196), Expect = 8e-15
Identities = 52/157 (33%), Positives = 78/157 (49%)
Query: 60 DVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLL 119
+V +L GN + N+ F LG+L L L+ + + + P TF LS L L+L +N L
Sbjct: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
Query: 120 QALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLG 179
+ +L L +L L N+++ L F+GL L L L N L LP PL
Sbjct: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
Query: 180 NLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQ 216
+L + NR+ L + A LG+LR+L+L N L+
Sbjct: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR 519
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 138 bits (347), Expect = 2e-32
Identities = 123/406 (30%), Positives = 170/406 (41%), Gaps = 27/406 (6%)
Query: 9 LLLVVCGCLALPPLA--EPVCPERCDCQ------------HPQHLLCTNRGLRVVPKTSS 54
LL V G A P+ CP +C CQ + C + L VP
Sbjct: 9 LLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPAL- 67
Query: 55 LPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYL 114
P T L N I + + L L LDL N F L +L L+L
Sbjct: 68 ---PAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHL 124
Query: 115 GNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAV 174
N L L + A L L+ LY N N++ R++ +F GL +L++L L+ N L A+
Sbjct: 125 EENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRW 184
Query: 175 FAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSL 234
F L NL L + N++ + F L LR L L+ L+ +A L+SL SL
Sbjct: 185 FEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYA--LEGLQSLESL 242
Query: 235 ILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEG-NRLSQLP 293
N L + R + +P L L L N L + P F + L+EL L L +
Sbjct: 243 SFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSID 302
Query: 294 TALLEPLHSLEALDLSGN-ELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALY 352
L L L LD++ N LS +HP F HL ++ L L NNALSAL + P L
Sbjct: 303 KFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQ 362
Query: 353 RLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLL-TVFVQCRHPPALR 397
+ L GN CDC + RW ++ R + C PP L+
Sbjct: 363 EVGLHGNPIRCDCVI----RWANATGTRVRFIEPQSTLCAEPPDLQ 404
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 138 bits (347), Expect = 2e-32
Identities = 123/406 (30%), Positives = 170/406 (41%), Gaps = 27/406 (6%)
Query: 9 LLLVVCGCLALPPLA--EPVCPERCDCQ------------HPQHLLCTNRGLRVVPKTSS 54
LL V G A P+ CP +C CQ + C + L VP
Sbjct: 9 LLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPAL- 67
Query: 55 LPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYL 114
P T L N I + + L L LDL N F L +L L+L
Sbjct: 68 ---PAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHL 124
Query: 115 GNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAV 174
N L L + A L L+ LY N N++ R++ +F GL +L++L L+ N L A+
Sbjct: 125 EENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRW 184
Query: 175 FAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSL 234
F L NL L + N++ + F L LR L L+ L+ +A L+SL SL
Sbjct: 185 FEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYA--LEGLQSLESL 242
Query: 235 ILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEG-NRLSQLP 293
N L + R + +P L L L N L + P F + L+EL L L +
Sbjct: 243 SFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSID 302
Query: 294 TALLEPLHSLEALDLSGN-ELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALY 352
L L L LD++ N LS +HP F HL ++ L L NNALSAL + P L
Sbjct: 303 KFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQ 362
Query: 353 RLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLL-TVFVQCRHPPALR 397
+ L GN CDC + RW ++ R + C PP L+
Sbjct: 363 EVGLHGNPIRCDCVI----RWANATGTRVRFIEPQSTLCAEPPDLQ 404
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 137 bits (345), Expect = 4e-32
Identities = 108/335 (32%), Positives = 146/335 (43%), Gaps = 23/335 (6%)
Query: 63 TYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQAL 122
T L N IT++ ++ L +L L +N +R + F+KL L+EL L N L L
Sbjct: 102 TLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFL 161
Query: 123 APGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLL 182
L L++L +GN ++ L +G L +L L N L +L + LG L
Sbjct: 162 PASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALT 221
Query: 183 YLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQ--PSL----RHAAT------------ 224
L N IR + AF +L L L LS N L PS H T
Sbjct: 222 ELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAEL 281
Query: 225 ----FAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLR-GNQLTHLAPEAFWGLEAL 279
F + L L L+ L+ L F++L RL L + +L+ L AF GL L
Sbjct: 282 PGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGEL 341
Query: 280 RELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSA 339
+ L L N L+ LP LL L L + L N L AL A F +L L + L +N L
Sbjct: 342 QVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLET 401
Query: 340 LSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWM 374
L GD+F A P L + L N W CDC L W+
Sbjct: 402 LPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWL 436
Score = 68.6 bits (166), Expect = 2e-11
Identities = 67/223 (30%), Positives = 97/223 (43%), Gaps = 29/223 (13%)
Query: 39 LLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSL 98
L + L +P L S H++ +L N + + F +G L+ L L Q+R+L
Sbjct: 247 LTLSRNHLAFLPSALFLHS-HNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTL 305
Query: 99 HPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLV 158
F LSRL YLG TL+P +S L +G+F+GL L
Sbjct: 306 PAAAFRNLSRLR--YLG---------VTLSP------------RLSALPQGAFQGLGELQ 342
Query: 159 KLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPS 218
L L N L ALPD + LG L + L NR+R L + F L L + L N+L+
Sbjct: 343 VLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLE-- 400
Query: 219 LRHAATFAPLRSLSSLILSANNLQ---HLGPRIFQHLPRLGLL 258
F L L+ ++L N+ + LGP + LGL+
Sbjct: 401 TLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLV 443
Score = 67.0 bits (162), Expect = 7e-11
Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 2/180 (1%)
Query: 180 NLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSAN 239
NL ++ L L +F+ + L+ L +S + + S TF+ L L +L LS N
Sbjct: 51 NLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHI--SAVAPGTFSDLIKLKTLRLSRN 108
Query: 240 NLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEP 299
+ HL + + L L L N L + F L L+EL L N+L LP +L
Sbjct: 109 KITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTN 168
Query: 300 LHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
L +L+ LDLSGN L+ L G +L L L +N L +L + + AL L N
Sbjct: 169 LENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRN 228
Score = 60.8 bits (146), Expect = 5e-09
Identities = 43/133 (32%), Positives = 64/133 (48%)
Query: 230 SLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRL 289
+L+ ++L L + F + L L + + ++ +AP F L L+ LRL N++
Sbjct: 51 NLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKI 110
Query: 290 SQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASP 349
+ LP ALL+ + LE L L N L + F L L+EL+L N L L +F
Sbjct: 111 THLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLE 170
Query: 350 ALYRLDLDGNGWT 362
L LDL GN T
Sbjct: 171 NLKLLDLSGNNLT 183
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 136 bits (342), Expect = 9e-32
Identities = 140/454 (30%), Positives = 190/454 (41%), Gaps = 71/454 (15%)
Query: 17 LALPPLAEPV--CPERCDCQ-HPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITN 73
L LP P CP RC+C + + CT R L VP +P+
Sbjct: 13 LLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVP--DGIPA---------------- 54
Query: 74 ITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKL 133
+ R L+L N+IR L+P L LEEL L N + + PG A L +L
Sbjct: 55 ----------ETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRL 104
Query: 134 RILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRF 193
R+L GN++ + G F L++L L L N L L D F L +L L + N + F
Sbjct: 105 RVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVF 164
Query: 194 LGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLP 253
+ + AFA L L L L L + + LRSL +L L + L + F+ LP
Sbjct: 165 VSRRAFAGLLALEELTLERCNL--TALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLP 222
Query: 254 RLGLL----------------SLRGNQLTHLA---------PEAFWGLEA-LRELRLEGN 287
GLL SLRG LT L+ P A +A L L L N
Sbjct: 223 --GLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHN 280
Query: 288 RLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAA 347
+S +P L L L L+G L+ + P F L ++R L+L NN LS L F +
Sbjct: 281 PISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHS 340
Query: 348 SPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQ 407
L L +DGN CDCRL + + + GRL C P +RG L L D
Sbjct: 341 VNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRL----PACATPAEVRGDALRNLPDS 396
Query: 408 QL-QNGSCADPSPSASLTADRRRQPLPTAAGEEM 440
L + C P +RR Q + AGE++
Sbjct: 397 VLFEYFVCRKPK-----IRERRLQRVTATAGEDV 425
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 134 bits (337), Expect = 3e-31
Identities = 121/358 (33%), Positives = 160/358 (44%), Gaps = 9/358 (2%)
Query: 17 LALPPLAEPVCPERCDC-QHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNIT 75
L LP + CP CDC PQ +LC +R L VP LP ++L L GN + +
Sbjct: 21 LLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVP--GGLPLDTELL--DLSGNRLWGLQ 76
Query: 76 AFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRI 135
RL L+ LDL YNQ+ +L P F L L L L N L+ + PG + L L +
Sbjct: 77 QGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTL 136
Query: 136 LYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLG 195
L N+I G+F L SL KL + N L + FA L L L LE + +
Sbjct: 137 LDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVP 196
Query: 196 KNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSA-NNLQHLGPRIFQHLPR 254
A A+L L L L EL A L L L + +L+ L P L
Sbjct: 197 GLALARLPALVALRL--RELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGL-N 253
Query: 255 LGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELS 314
L L++ L+ + +A + L LR L L N +S +P L PL L+ L LSG L+
Sbjct: 254 LSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLT 313
Query: 315 ALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKR 372
++ F L L + +NAL L F + L L L GN TCDCRL L R
Sbjct: 314 SIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLR 371
>gi|12007646 nyctalopin precursor [Homo sapiens]
Length = 481
Score = 134 bits (336), Expect = 4e-31
Identities = 134/472 (28%), Positives = 192/472 (40%), Gaps = 46/472 (9%)
Query: 5 RALRLLLVVCGCLALPPL-----AEPVCPERCDCQHPQH---LLCTNRGLRVVPKTSSLP 56
R + +LL+ L LP CP C C + + C GL VP
Sbjct: 4 RGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAEL--- 60
Query: 57 SPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGN 116
P + ++ L N + + F L LRRL L++N + + P F+ L RL EL L +
Sbjct: 61 -PCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAH 119
Query: 117 NL-LQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVF 175
N L+ L T A L +LR L + + L +L +L N +P A+
Sbjct: 120 NGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALR 179
Query: 176 APLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLI 235
L NL + HLE RI + ++ L +LR L+L AN ++ HA F L L+
Sbjct: 180 G-LANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAV--HAGAFGDCGVLEHLL 236
Query: 236 LSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTA 295
L+ N L L +AF GL LR L L GN L ++ A
Sbjct: 237 LN------------------------DNLLAELPADAFRGLRRLRTLNLGGNALDRVARA 272
Query: 296 LLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLD 355
L LE L L N ++ + F +L L L L N L+ L+ F L RL
Sbjct: 273 WFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLF 332
Query: 356 LDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQNGSCA 415
L N W CDCRL L+ WM GR+ V C P ++ G L + + +G C
Sbjct: 333 LFRNPWCCDCRLEWLRDWM---EGSGRVTD--VPCASPGSVAGLDLSQVTFGRSSDGLCV 387
Query: 416 DPSPSASLTADRRRQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRFLAGVA 467
DP T+ P P A L++ L P+ +++ G+A
Sbjct: 388 DPEELNLTTSSPGPSPEPAATTVSRFSSL-LSKLLAPRVPVEEAANTTGGLA 438
>gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo
sapiens]
Length = 754
Score = 133 bits (335), Expect = 6e-31
Identities = 92/276 (33%), Positives = 142/276 (51%), Gaps = 8/276 (2%)
Query: 28 PERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRR 87
P+ CDC+ + L C N L+ VP S+ +V SL N I ++ F + +L++
Sbjct: 112 PQCCDCKETE-LECVNGDLKSVPMISN-----NVTLLSLKKNKIHSLPDKVFIKYTKLKK 165
Query: 88 LDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLS 147
+ LQ+N IR + K F L L+ LYL +N + L PG L +L L + N I+R+S
Sbjct: 166 IFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRIS 225
Query: 148 RGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRF 207
+ F GL SL L + N L ALP + A + L ++ LE NRI++L + F L
Sbjct: 226 QRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTV 285
Query: 208 LNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTH 267
L L N++ TF+ L++L L LS+N + L P +F+ L L L+L N L +
Sbjct: 286 LFLPRNQI--GFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMY 343
Query: 268 LAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSL 303
L F L+ L+ L LE + + T + +P+ +L
Sbjct: 344 LHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNL 379
Score = 83.2 bits (204), Expect = 9e-16
Identities = 65/203 (32%), Positives = 94/203 (46%), Gaps = 8/203 (3%)
Query: 160 LRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSAN---ELQ 216
L L N + +LPD VF L + L+ N IR + + AF L L+ L L+ N L+
Sbjct: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
Query: 217 PSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGL 276
P + F L L+ LIL N + + R+F L L LS+ N L L + +
Sbjct: 202 PGI-----FKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQM 256
Query: 277 EALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNA 336
L + LEGNR+ L + SL L L N++ + TF L L EL L +N
Sbjct: 257 PQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNT 316
Query: 337 LSALSGDIFAASPALYRLDLDGN 359
++ LS +F L +L+L N
Sbjct: 317 ITELSPHLFKDLKLLQKLNLSSN 339
Score = 61.6 bits (148), Expect = 3e-09
Identities = 41/130 (31%), Positives = 67/130 (51%)
Query: 230 SLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRL 289
+++ L L N + L ++F +L + L+ N + H++ +AF+GL L+ L L N +
Sbjct: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
Query: 290 SQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASP 349
+ L + + LH L L L N ++ + F L L LS+ NN L AL + A P
Sbjct: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
Query: 350 ALYRLDLDGN 359
L +DL+GN
Sbjct: 258 QLNWVDLEGN 267
Score = 58.2 bits (139), Expect = 3e-08
Identities = 45/152 (29%), Positives = 68/152 (44%), Gaps = 1/152 (0%)
Query: 39 LLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSL 98
L N L +PK P + L GN I +T F L L L NQI +
Sbjct: 238 LSMVNNYLEALPKQMCAQMPQ-LNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFV 296
Query: 99 HPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLV 158
KTF L L EL L +N + L+P L+ L+ L + N + L + FE L+ L
Sbjct: 297 PEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQ 356
Query: 159 KLRLDGNALGALPDAVFAPLGNLLYLHLESNR 190
L L+ + + +F P+ NL +++ ++ R
Sbjct: 357 SLDLERIEIPNINTRMFQPMKNLSHIYFKNFR 388
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 133 bits (334), Expect = 8e-31
Identities = 124/470 (26%), Positives = 183/470 (38%), Gaps = 90/470 (19%)
Query: 19 LPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFD 78
L +A CP +C C + C LR VP+ P + L GN IT IT D
Sbjct: 20 LNKVAPQACPAQCSCSGST-VDCHGLALRSVPRNI----PRNTERLDLNGNNITRITKTD 74
Query: 79 FHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQ------------------ 120
F L LR L L N+I ++ F+ L LE L L N LQ
Sbjct: 75 FAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDL 134
Query: 121 ------------------------------ALAPGTLAPLRKLRILYANGNEISRLSRGS 150
+ G LR L +L N N I+RLS S
Sbjct: 135 SENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVAS 194
Query: 151 FEGLESLVKLRLDGNALGALPDAVFAPLGNLLYL--------------HLESNRIRFLGK 196
F + L RL N L D A L + L HL + + + K
Sbjct: 195 FNHMPKLRTFRLHSNNLYC--DCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQK 252
Query: 197 NAFAQLGKLRFLNLSANELQ----------------PSLRHAATFAPLRSLSSLILSANN 240
F G F+ S + L L T P +++ + L N
Sbjct: 253 REFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLP-ETITEIRLEQNT 311
Query: 241 LQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPL 300
++ + P F +L + L NQ++ LAP+AF GL +L L L GN++++LP +L E L
Sbjct: 312 IKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGL 371
Query: 301 HSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNG 360
SL+ L L+ N+++ L F L L LSL +N L ++ F+ A+ + L N
Sbjct: 372 FSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNP 431
Query: 361 WTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQ 410
+ CDC L +W+ D+ + T +C P L K + + ++ +
Sbjct: 432 FICDCHL----KWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFR 477
Score = 94.7 bits (234), Expect = 3e-19
Identities = 98/369 (26%), Positives = 157/369 (42%), Gaps = 27/369 (7%)
Query: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
L GN IT + F L L+ L L N+I L F+ L L L L +N LQ +A G
Sbjct: 355 LYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKG 414
Query: 126 TLAPLRKLRILYANGNEI----------SRLSRGSFE--GLESLVKLRLDGNALGALPDA 173
T +PLR ++ ++ N L E G RL +G +
Sbjct: 415 TFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSK 474
Query: 174 VFAPLGNLLYL--HLESNRIRFLGKNAFAQLG---KLRFLNLSANELQPSLRHAATFAPL 228
F Y E R + G + FA L K R + + L P
Sbjct: 475 KFRCSAKEQYFIPGTEDYRSKLSG-DCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIP- 532
Query: 229 RSLSSLILSANNLQHL-GPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGN 287
+ + L L+ N L IF+ LP+L ++ N++T + AF G + E+ L N
Sbjct: 533 QYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSN 592
Query: 288 RLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAA 347
RL + + + L SL+ L L N ++ + +F L +R LSL +N ++ ++ F
Sbjct: 593 RLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDT 652
Query: 348 SPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQ 407
+L L+L N + C+C L W+G+W + R++T +C+ P L+ + D
Sbjct: 653 LHSLSTLNLLANPFNCNCYLA----WLGEWLRKKRIVTGNPRCQKPYFLKE---IPIQDV 705
Query: 408 QLQNGSCAD 416
+Q+ +C D
Sbjct: 706 AIQDFTCDD 714
Score = 94.4 bits (233), Expect = 4e-19
Identities = 105/410 (25%), Positives = 165/410 (40%), Gaps = 45/410 (10%)
Query: 23 AEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFD-FHR 81
A+ CPE+C C+ + C+N+ L +P+ P L N T + A F +
Sbjct: 502 ADLACPEKCRCEGTT-VDCSNQKLNKIPEHI----PQYTAELRLNNNEFTVLEATGIFKK 556
Query: 82 LGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGN 141
L QLR+++ N+I + FE S + E+ L +N L+ + L L+ L N
Sbjct: 557 LPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSN 616
Query: 142 EISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESN------RIRFLG 195
I+ + SF GL S+ L L N + + F L +L L+L +N + +LG
Sbjct: 617 RITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLG 676
Query: 196 KNAFAQLGKLRFLNLSANELQP------SLRHAA-------------TFAPLRSLSSLIL 236
+ L K R + + +P ++ A + +PL +
Sbjct: 677 E----WLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECT 732
Query: 237 SANNLQHLGPRIFQHLPR-----LGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQ 291
+ + + + LP+ + L L GNQ T L P+ + L + L NR+S
Sbjct: 733 CLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFT-LVPKELSNYKHLTLIDLSNNRIST 791
Query: 292 LPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPAL 351
L + L L LS N L + P TF L LR LSL N +S + F AL
Sbjct: 792 LSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSAL 851
Query: 352 YRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYL 401
L + N CDC + +W+ DW +C P + K L
Sbjct: 852 SHLAIGANPLYCDCNM----QWLSDWVKSEYKEPGIARCAGPGEMADKLL 897
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 131 bits (330), Expect = 2e-30
Identities = 115/396 (29%), Positives = 185/396 (46%), Gaps = 20/396 (5%)
Query: 40 LCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNI-TAFDFHRLGQLRRLDLQYNQIRSL 98
L NR + ++P+ L + T L N I+ + TAF QL+ L L N++ S+
Sbjct: 128 LAGNRIVEILPE--HLKEFQSLETLDLSSNNISELQTAFPAL---QLKYLYLNSNRVTSM 182
Query: 99 HPKTFEKLSR-LEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESL 157
P F+ L+ L L L N + A+ P + L +L+ L N N+I + +F+GL +L
Sbjct: 183 EPGYFDNLANTLLVLKLNRNRISAIPP-KMFKLPQLQHLELNRNKIKNVDGLTFQGLGAL 241
Query: 158 VKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQP 217
L++ N + L D F L N+ L L+ N + + K L L+ L+LS N +
Sbjct: 242 KSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINR 301
Query: 218 SLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLE 277
A F + LS L L+ N+L L F L L L + N+++++A AF GL
Sbjct: 302 ISPDAWEFC--QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLS 359
Query: 278 ALRELRLEGNRLS---QLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRN 334
+L+ L L+ N +S + L L L L GN + ++ F L L L L +
Sbjct: 360 SLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSD 419
Query: 335 NALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPP 394
NA+ +L G+ F+ L +L L+ + CDC+L+ L +W+ + + Q V C HP
Sbjct: 420 NAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQS---FVNASCAHPQ 476
Query: 395 ALRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQ 430
L+G+ + + +G D P +T Q
Sbjct: 477 LLKGRSIFAVS----PDGFVCDDFPKPQITVQPETQ 508
Score = 104 bits (260), Expect = 3e-22
Identities = 102/345 (29%), Positives = 154/345 (44%), Gaps = 14/345 (4%)
Query: 23 AEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRL 82
AE CP C C L C+ + L +P+ P P V L N ++ I A L
Sbjct: 43 AERPCPTTCRCLGDL-LDCSRKRLARLPE----PLPSWVARLDLSHNRLSFIKASSMSHL 97
Query: 83 GQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNE 142
LR + L N++ ++ P + + L L N + + P L + L L + N
Sbjct: 98 QSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNN 156
Query: 143 ISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGN-LLYLHLESNRIRFLGKNAFAQ 201
IS L +F L+ L L L+ N + ++ F L N LL L L NRI + F +
Sbjct: 157 ISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-K 213
Query: 202 LGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLR 261
L +L+ L L+ N+++ TF L +L SL + N + L F L + +L L
Sbjct: 214 LPQLQHLELNRNKIKNV--DGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLD 271
Query: 262 GNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATF 321
N LT + +GL L+EL L N ++++ E L LDL+ N LS L ++F
Sbjct: 272 HNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSF 331
Query: 322 GHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN--GWTCD 364
L L L + NN +S ++ F +L LDL N WT +
Sbjct: 332 LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIE 376
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 131 bits (330), Expect = 2e-30
Identities = 115/396 (29%), Positives = 185/396 (46%), Gaps = 20/396 (5%)
Query: 40 LCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNI-TAFDFHRLGQLRRLDLQYNQIRSL 98
L NR + ++P+ L + T L N I+ + TAF QL+ L L N++ S+
Sbjct: 68 LAGNRIVEILPE--HLKEFQSLETLDLSSNNISELQTAFPAL---QLKYLYLNSNRVTSM 122
Query: 99 HPKTFEKLSR-LEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESL 157
P F+ L+ L L L N + A+ P + L +L+ L N N+I + +F+GL +L
Sbjct: 123 EPGYFDNLANTLLVLKLNRNRISAIPP-KMFKLPQLQHLELNRNKIKNVDGLTFQGLGAL 181
Query: 158 VKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQP 217
L++ N + L D F L N+ L L+ N + + K L L+ L+LS N +
Sbjct: 182 KSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINR 241
Query: 218 SLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLE 277
A F + LS L L+ N+L L F L L L + N+++++A AF GL
Sbjct: 242 ISPDAWEFC--QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLS 299
Query: 278 ALRELRLEGNRLS---QLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRN 334
+L+ L L+ N +S + L L L L GN + ++ F L L L L +
Sbjct: 300 SLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSD 359
Query: 335 NALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPP 394
NA+ +L G+ F+ L +L L+ + CDC+L+ L +W+ + + Q V C HP
Sbjct: 360 NAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQS---FVNASCAHPQ 416
Query: 395 ALRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQ 430
L+G+ + + +G D P +T Q
Sbjct: 417 LLKGRSIFAVS----PDGFVCDDFPKPQITVQPETQ 448
Score = 94.7 bits (234), Expect = 3e-19
Identities = 89/313 (28%), Positives = 132/313 (42%), Gaps = 29/313 (9%)
Query: 77 FDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLR-KLRI 135
F L + R DL +N++ + + L L E+ L NN L+ + L P+ + +
Sbjct: 8 FSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP--NLGPVSANITL 65
Query: 136 LYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLG 195
L GN I + + +SL L L N + L A P L YL+L SNR+ +
Sbjct: 66 LSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAF--PALQLKYLYLNSNRVTSME 123
Query: 196 KNAFAQLGK-LRFLNLSANELQ---------PSLRH------------AATFAPLRSLSS 233
F L L L L+ N + P L+H TF L +L S
Sbjct: 124 PGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKS 183
Query: 234 LILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLP 293
L + N + L F L + +L L N LT + +GL L+EL L N ++++
Sbjct: 184 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 243
Query: 294 TALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYR 353
E L LDL+ N LS L ++F L L L + NN +S ++ F +L
Sbjct: 244 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 303
Query: 354 LDLDGN--GWTCD 364
LDL N WT +
Sbjct: 304 LDLKNNEISWTIE 316
>gi|88702793 slit-like 2 [Homo sapiens]
Length = 673
Score = 131 bits (329), Expect = 3e-30
Identities = 138/457 (30%), Positives = 184/457 (40%), Gaps = 81/457 (17%)
Query: 9 LLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGG 68
LLL + LAL P + CP C C PQ + CT R VP+ P D + +
Sbjct: 7 LLLPLLLLLALGPGVQG-CPSGCQCSQPQTVFCTARQGTTVPRDV----PPDTVGLYVFE 61
Query: 69 NFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLA 128
N IT + A F L L+ LDL NQI SL F+ L+ L L L N L + T
Sbjct: 62 NGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFR 121
Query: 129 PLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLES 188
LR+L LY N I + G+F+ L+ L++L+L N L ALP PL
Sbjct: 122 GLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALP-----PL---------- 166
Query: 189 NRIRFLGKNAFAQLGKLRFLNLSANE---LQPSLRHAATFAPLRSLSSLILSANNLQHLG 245
+L +L L+LS N L+P + A LR L+ LQ L
Sbjct: 167 ------------RLPRLLLLDLSHNSLLALEPGILDTANVEALR------LAGLGLQQLD 208
Query: 246 PRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGN-RLSQLPTALLEPLHSLE 304
+F L L L + NQL + P GL L LRL GN R++QL L L +L+
Sbjct: 209 EGLFSRLRNLHDLDVSDNQLERV-PPVIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQ 267
Query: 305 ALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCD 364
LD+S N +L AL GD+ P L L N + C
Sbjct: 268 ELDVS------------------------NLSLQALPGDLSGLFPRLRLLAAARNPFNCV 303
Query: 365 CRLRGLKRWMGDWHSQGRLLTVF---VQCRHPPALRGKYLDYLDDQQLQNGSCADPSPSA 421
C L W G W + + +C PP G+ L LD + C + +A
Sbjct: 304 CPL----SWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELD---YADFGCPATTTTA 356
Query: 422 SLTADRRRQPLPTAAGEEMTP----PAGLAEELPPQP 454
++ R PTA + P P A E P P
Sbjct: 357 TVPTTRPVVREPTALSSSLAPTWLSPTEPATEAPSPP 393
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 130 bits (326), Expect = 6e-30
Identities = 114/401 (28%), Positives = 170/401 (42%), Gaps = 70/401 (17%)
Query: 27 CPERCDCQHPQHLL----CTNRGLRVVPKTSS----------------LPSPHDVLTY-- 64
CP C C+ +L C++ GL +P S LP+P L +
Sbjct: 34 CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLE 93
Query: 65 --SLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQAL 122
L GN +T I F L L+ L LQ NQ+R + + + L L+ L L N + +
Sbjct: 94 ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYV 153
Query: 123 APGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLL 182
P + L LR L+ + N ++ + +F L +L + L N + +PD F L +L+
Sbjct: 154 PPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213
Query: 183 YLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLR------------- 229
LHL +NRI LGK F L L L+L+ N L T + L+
Sbjct: 214 VLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIP 273
Query: 230 --------SLSSLILSANNLQHLGPRIFQHLPRLGLLSLRG-NQLTHLAPEAFWGLEALR 280
SL ++ N +Q +G FQHLP L L+L G +Q+T G L
Sbjct: 274 EKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPD--LTGTANLE 331
Query: 281 ELRLEGNRLSQLPTALLEPLHSLEALDLS----------------------GNELSALHP 318
L L G ++S LP + L +L+ LDLS NE+ +
Sbjct: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKV 391
Query: 319 ATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
TF L LR L+L N ++ + + F+ P+L +LDL N
Sbjct: 392 DTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432
Score = 83.2 bits (204), Expect = 9e-16
Identities = 88/340 (25%), Positives = 135/340 (39%), Gaps = 72/340 (21%)
Query: 39 LLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSL 98
L+ N LR VP T +L + + + L N I+ + F L LR L L N + +
Sbjct: 119 LMLQNNQLRHVP-TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEI 177
Query: 99 HPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLV 158
+ F LS L+ + L N + + L L +L+ + N I L + F+GL SL
Sbjct: 178 PVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLE 237
Query: 159 KLRLDGNALGALPDAV-----------------------FAPLGNLLYLHLESNRIRFLG 195
L L+ N L P A+ F +L+ +H N I+F+G
Sbjct: 238 TLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVG 297
Query: 196 KNAFAQLGKLRFLNLSA----------------------------------NELQPSLR- 220
++AF L +LR L L+ N+L P+L+
Sbjct: 298 RSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQL-PNLQV 356
Query: 221 ---------HAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPE 271
+F+ + L + L N + + FQ L L L+L N++ + P
Sbjct: 357 LDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPN 416
Query: 272 AFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGN 311
AF L +L +L L N LS P + LH L L L+GN
Sbjct: 417 AFSTLPSLIKLDLSSNLLSSFP---ITGLHGLTHLKLTGN 453
Score = 52.0 bits (123), Expect = 2e-06
Identities = 35/105 (33%), Positives = 49/105 (46%)
Query: 258 LSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALH 317
L L N ++ L P L L ELRL GN L+ +P L+SL+ L L N+L +
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
Query: 318 PATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWT 362
+L L+ L L N +S + F+ +L L LD N T
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALT 175
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 127 bits (319), Expect = 4e-29
Identities = 128/477 (26%), Positives = 201/477 (42%), Gaps = 83/477 (17%)
Query: 4 ARALRLLLVVC--GCLALPPLAEPVCPERCDCQHPQHLLCTNRGLR----------VVPK 51
+R L LL + L LP +CP C C+ P L C+ R L + P
Sbjct: 18 SRVLSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPL-LDCSRRKLPAPSWRALSGLLPPD 76
Query: 52 TSSLPSPHDVLT-------------YSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSL 98
T+ L H+ L+ + N +T I F + L L +N I +
Sbjct: 77 TAILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFG-EPTSNITLLSLVHNIIPEI 135
Query: 99 HPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLES-L 157
+ + + LE L L +N++ + + P +L+ L + N I+ L G F+ L S L
Sbjct: 136 NAQALQFYPALESLDLSSNIISEIKTSSF-PRMQLKYLNLSNNRITTLEAGCFDNLSSSL 194
Query: 158 VKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQP 217
+ ++L+ N + +P +F L +L +L L+ NRI+ + F L LR L + N +
Sbjct: 195 LVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGIS- 252
Query: 218 SLRHAATFA-----------------------PLRSLSSLILSANNLQHLGPRIFQHLPR 254
L+ A F LR L L +S N ++ + P ++ R
Sbjct: 253 KLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQR 312
Query: 255 LGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELS 314
L L L NQLT L AF GL L L L NR++ + + L +L+ LDL NE+S
Sbjct: 313 LSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEIS 372
Query: 315 -ALHPAT--FGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN------------ 359
A+ A+ F L L +L L+ N + +++ F +L LDL+ N
Sbjct: 373 WAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQ 432
Query: 360 -----------GWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLD 405
CDC L+ L +W+ D + Q +V V C HP L G+ + +D
Sbjct: 433 THLKELILNTSSLLCDCHLKWLLQWLVDNNFQH---SVNVSCAHPEWLAGQSILNVD 486
>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
Length = 473
Score = 126 bits (317), Expect = 7e-29
Identities = 96/257 (37%), Positives = 122/257 (47%), Gaps = 5/257 (1%)
Query: 159 KLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPS 218
++ L GN + +P A F NL L L SN + + AF L L L+LS N S
Sbjct: 61 RIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRS 120
Query: 219 LRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEA 278
+ ATF L L +L L LQ LGP +F+ L L L L+ N L L + F L
Sbjct: 121 V-DPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
Query: 279 LRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALS 338
L L L GNR+S +P LHSL+ L L N ++ +HP F LGRL L L N LS
Sbjct: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
Query: 339 ALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRG 398
AL + A AL L L+ N W CDCR R L W+ + + V C P L G
Sbjct: 240 ALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGS----SSEVPCSLPQRLAG 295
Query: 399 KYLDYLDDQQLQNGSCA 415
+ L L LQ + A
Sbjct: 296 RDLKRLAANDLQGCAVA 312
Score = 96.7 bits (239), Expect = 8e-20
Identities = 78/236 (33%), Positives = 107/236 (45%), Gaps = 25/236 (10%)
Query: 27 CPERCDCQHPQHLL--CTNRGLRVVP---------------KTSSLPSP-----HDVLTY 64
CP C C + + C +GL+ VP + S +P+ ++
Sbjct: 27 CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTIL 86
Query: 65 SLGGNFITNITAFDFHRLGQLRRLDLQYN-QIRSLHPKTFEKLSRLEELYLGNNLLQALA 123
L N + I A F L L +LDL N Q+RS+ P TF L RL L+L LQ L
Sbjct: 87 WLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELG 146
Query: 124 PGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLY 183
PG L L+ LY N + L +F L +L L L GN + ++P+ F L +L
Sbjct: 147 PGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDR 206
Query: 184 LHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSAN 239
L L NR+ + +AF LG+L L L AN L S APLR+L L L+ N
Sbjct: 207 LLLHQNRVAHVHPHAFRDLGRLMTLYLFANNL--SALPTEALAPLRALQYLRLNDN 260
Score = 40.8 bits (94), Expect = 0.005
Identities = 37/107 (34%), Positives = 45/107 (42%), Gaps = 25/107 (23%)
Query: 278 ALRELRLEGNRLSQLPTALLEP--------LHS----------------LEALDLSGN-E 312
A + + L GNR+S +P A LHS LE LDLS N +
Sbjct: 58 ASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQ 117
Query: 313 LSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
L ++ PATF LGRL L L L L +F AL L L N
Sbjct: 118 LRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDN 164
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 125 bits (314), Expect = 2e-28
Identities = 104/321 (32%), Positives = 153/321 (47%), Gaps = 10/321 (3%)
Query: 112 LYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALP 171
L L +N + L A +L L+ + N+IS + +F+GL L +L L N + LP
Sbjct: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
Query: 172 DAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSL 231
+ F L NL L L N++ L F L KL+ L+L +N L+ F RSL
Sbjct: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTI--PVRLFWDCRSL 183
Query: 232 SSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQ 291
L LS N L+ L F L +L L L NQLT + F L +L L L+ N++S
Sbjct: 184 EFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISN 243
Query: 292 LPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPAL 351
L + +LE LDL+GNE+ A+ F + L+ L + NN L++L I + +L
Sbjct: 244 LTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSL 303
Query: 352 YRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGK-YLDYLDDQQLQ 410
+ L GN W C R+ L W+G + QGR + C P +G+ LD + QL
Sbjct: 304 TTVGLSGNLWECSARICALASWLGSF--QGR-WEHSILCHSPDHTQGEDILDAVHGFQL- 359
Query: 411 NGSCADPSPSASLTADRRRQP 431
C + S + ++ A R P
Sbjct: 360 ---CWNLSTTVTVMATTYRDP 377
Score = 123 bits (308), Expect = 8e-28
Identities = 96/295 (32%), Positives = 143/295 (48%), Gaps = 7/295 (2%)
Query: 17 LALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITA 76
L + P CP +C C+ C ++G VP + S L SL N IT +
Sbjct: 24 LKMLPALGMACPPKCRCEKLL-FYCDSQGFHSVPNATDKGS----LGLSLRHNHITELER 78
Query: 77 FDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRIL 136
F QL L L +NQI ++ F+ L +L+EL L +N + L T L L+ L
Sbjct: 79 DQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNL 138
Query: 137 YANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGK 196
+ N++S L F GL L L L N+L +P +F +L +L L +NR+R L +
Sbjct: 139 DLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLAR 198
Query: 197 NAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLG 256
N FA L KLR L+L N+L + + A F L SL +L L N + +L + L
Sbjct: 199 NGFAGLIKLRELHLEHNQL--TKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLE 256
Query: 257 LLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGN 311
L L GN++ + F + L+ L ++ N+L+ L + +L L SL + LSGN
Sbjct: 257 KLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
Score = 73.9 bits (180), Expect = 5e-13
Identities = 54/152 (35%), Positives = 77/152 (50%), Gaps = 6/152 (3%)
Query: 221 HAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALR 280
H+ A + L L N++ L F +L L L NQ++ + +AF GL L+
Sbjct: 53 HSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLK 112
Query: 281 ELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSAL 340
EL L N++ LP L +L+ LDLS N+LS+LHP F L +L+ L LR+N+L +
Sbjct: 113 ELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTI 172
Query: 341 SGDIFAASPALYRLDLDGNGWTCDCRLRGLKR 372
+F +L LDL N RLR L R
Sbjct: 173 PVRLFWDCRSLEFLDLSTN------RLRSLAR 198
Score = 62.8 bits (151), Expect = 1e-09
Identities = 51/161 (31%), Positives = 72/161 (44%)
Query: 63 TYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQAL 122
T L N + I F L LDL N++RSL F L +L EL+L +N L +
Sbjct: 161 TLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKI 220
Query: 123 APGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLL 182
L L L+ N+IS L+ G +L KL L GN + A+ VF + NL
Sbjct: 221 NFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLK 280
Query: 183 YLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAA 223
L +++N++ L L L + LS N + S R A
Sbjct: 281 ILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICA 321
>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
sapiens]
Length = 757
Score = 124 bits (311), Expect = 3e-28
Identities = 94/277 (33%), Positives = 132/277 (47%), Gaps = 9/277 (3%)
Query: 28 PERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRR 87
P +C CQ + L C LR VP SS +V SL N I + F L++
Sbjct: 101 PVQCLCQGLE-LDCDETNLRAVPSVSS-----NVTAMSLQWNLIRKLPPDCFKNYHDLQK 154
Query: 88 LDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLS 147
L LQ N+I S+ F L+ L +LYL +N + L PG L +L L N +SR+S
Sbjct: 155 LYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRIS 214
Query: 148 RGSFEGLESLVKLRLDGNALGALPDAVFAP-LGNLLYLHLESNRIRFLGKNAFAQLGKLR 206
+F GL SL+ L L N L LPD + L +L LE N I L F L
Sbjct: 215 PPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLT 274
Query: 207 FLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLT 266
L + N++ + + TFAPL+ L L L +N +++L P IF+ L L L+L N +
Sbjct: 275 VLVMRKNKI--NHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQ 332
Query: 267 HLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSL 303
+ F L L+ L LEG +S + + PL +L
Sbjct: 333 KIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNL 369
Score = 93.6 bits (231), Expect = 7e-19
Identities = 71/219 (32%), Positives = 100/219 (45%), Gaps = 3/219 (1%)
Query: 141 NEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFA 200
N I +L F+ L KL L N + ++ F L +L L+L NRI FL F
Sbjct: 136 NLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFE 195
Query: 201 QLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPR-IFQHLPRLGLLS 259
L +L +L + N L S TF L SL L+L N L L + + QH+PRL L
Sbjct: 196 DLHRLEWLIIEDNHL--SRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLD 253
Query: 260 LRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPA 319
L GN + +L F L L + N+++ L PL L+ LDL N++ L P
Sbjct: 254 LEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPL 313
Query: 320 TFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDG 358
F L L +L+L N + + + F L L L+G
Sbjct: 314 IFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEG 352
Score = 70.5 bits (171), Expect = 6e-12
Identities = 62/205 (30%), Positives = 91/205 (44%), Gaps = 3/205 (1%)
Query: 156 SLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANEL 215
++ + L N + LP F +L L+L++N+I + AF L L L LS N +
Sbjct: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
Query: 216 QPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWG 275
+ F L L LI+ N+L + P F L L LL L N LT L +
Sbjct: 187 --TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQ 244
Query: 276 -LEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRN 334
+ L L LEGN + L +L L + N+++ L+ TF L +L EL L +
Sbjct: 245 HMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGS 304
Query: 335 NALSALSGDIFAASPALYRLDLDGN 359
N + L IF L +L+L N
Sbjct: 305 NKIENLPPLIFKDLKELSQLNLSYN 329
Score = 62.4 bits (150), Expect = 2e-09
Identities = 38/122 (31%), Positives = 62/122 (50%)
Query: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
L GN I N+ F L L ++ N+I L+ TF L +L+EL LG+N ++ L P
Sbjct: 254 LEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPL 313
Query: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185
L++L L + N I ++ F+ L L L L+G + + +F PL NL +++
Sbjct: 314 IFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIY 373
Query: 186 LE 187
+
Sbjct: 374 FK 375
>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
Length = 420
Score = 124 bits (310), Expect = 5e-28
Identities = 107/308 (34%), Positives = 134/308 (43%), Gaps = 10/308 (3%)
Query: 156 SLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANEL 215
S +L L N + L F NLL L L SN + + F L L L+L N
Sbjct: 61 STQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRH 118
Query: 216 QPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWG 275
SL TF L L SL L L L IF+ L L L L+ N L HL + F
Sbjct: 119 LRSLE-PDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFAD 177
Query: 276 LEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNN 335
L L L L GNRL L + L SL+ L L GN L +H A F L RL L L NN
Sbjct: 178 LANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNN 237
Query: 336 ALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPA 395
+L++L G+ A P+L L L+ N W CDCR R L W W + R+ + V C PP
Sbjct: 238 SLASLPGEALADLPSLEFLRLNANPWACDCRARPL--WA--WFQRARVSSSDVTCATPPE 293
Query: 396 LRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQPLPTAAGEEMTPPAG---LAEELPP 452
+G+ L L + Q A P+ S E PPA L +LP
Sbjct: 294 RQGRDLRALREADFQACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADPSTLYRDLPA 353
Query: 453 QPQLQQQG 460
+ +QG
Sbjct: 354 EDSRGRQG 361
Score = 92.4 bits (228), Expect = 1e-18
Identities = 96/285 (33%), Positives = 121/285 (42%), Gaps = 54/285 (18%)
Query: 1 MEAARALRLLLVVCGCLALPPLAEPVCPERCDC-QHPQHLLCTNRGLRVVPKTSSLPSP- 58
++A + LLL++ LALP LA P CP C C P + C VP SLP
Sbjct: 9 LQAPASACLLLML---LALP-LAAPSCPMLCTCYSSPPTVSCQANNFSSVPL--SLPPST 62
Query: 59 -------------------HDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQ-IRSL 98
++LT L N ++ I F L L LDL N+ +RSL
Sbjct: 63 QRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSL 122
Query: 99 HPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLV 158
P TF+ L RL+ L+L L +L PG + F GL SL
Sbjct: 123 EPDTFQGLERLQSLHLYRCQLSSL-PGNI-----------------------FRGLVSLQ 158
Query: 159 KLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPS 218
L L N+L L D +FA L NL +L L NR+R L ++ F LG L L L N LQ
Sbjct: 159 YLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGV 218
Query: 219 LRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGN 263
H A F L L+ L L N+L L LP L L L N
Sbjct: 219 --HRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 123 bits (309), Expect = 6e-28
Identities = 122/455 (26%), Positives = 185/455 (40%), Gaps = 84/455 (18%)
Query: 27 CPERCDCQ-HPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQL 85
CP RC+C + + C R L +P+ + +
Sbjct: 28 CPARCECSAQNKSVSCHRRRLIAIPEGIPI----------------------------ET 59
Query: 86 RRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISR 145
+ LDL N+++S++P+ F LEE+ L +N++ + PG L LR L GN +
Sbjct: 60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKL 119
Query: 146 LSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKL 205
+ G F GL +L KL + N + L D +F L NL L + N + ++ AF+ L L
Sbjct: 120 VPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSL 179
Query: 206 RFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHL-----------PR 254
L L L A + LRSL SL L N+ ++ F+ L P
Sbjct: 180 EQLTLEKCNLTAVPTEA--LSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPL 237
Query: 255 LGLL---SLRGNQLTHLAPE----------AFWGLEALRELRLEGNRLSQLPTALLEPLH 301
L ++ SL G LT L+ AF L L L L N +S + + L
Sbjct: 238 LDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLI 297
Query: 302 SLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGW 361
L+ L + G +L + P +F L LR L++ N L L ++F++ AL L ++ N
Sbjct: 298 RLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
Query: 362 TCDCRLRGL-----------------------KRWMGDWHSQGRLLTVFVQCRHPPALRG 398
CDCRL + +R D+HS L+ + C+ P
Sbjct: 358 ACDCRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTA--LSFYFTCKKPKIREK 415
Query: 399 KYLDYLDDQ----QLQNGSCADPSPSASLTADRRR 429
K L D+ QL+ + DP P S RRR
Sbjct: 416 KLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRR 450
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 122 bits (307), Expect = 1e-27
Identities = 107/307 (34%), Positives = 133/307 (43%), Gaps = 32/307 (10%)
Query: 9 LLLVVCGCLALPPLAEPV---CPERCDCQHPQ-HLLCTNRGLRVVPKTSSLPSPHDVLTY 64
L+L + L L P + CP+ C C + + H+ C + L VP P
Sbjct: 12 LVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAI----PELTQRL 67
Query: 65 SLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAP 124
L GN + I A F + L LDL++ ++ + F L RL L L +N L+ L
Sbjct: 68 DLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQ 127
Query: 125 GTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYL 184
L L LR L GN + L G+F L +L L L NAL LP F L + +L
Sbjct: 128 EALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWL 187
Query: 185 HLESNRIRFLGKNAFAQLGKLRFLNLSANELQ----PSLRHAATFAPLR----------- 229
L N + L A A L LR L+L NELQ P L A A L
Sbjct: 188 RLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGE 247
Query: 230 -------SLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALREL 282
L L+L LQ LGPR F H PRL L LRGNQL L P G LR L
Sbjct: 248 EDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRL 305
Query: 283 RLEGNRL 289
RL+GN L
Sbjct: 306 RLQGNPL 312
Score = 120 bits (302), Expect = 4e-27
Identities = 111/339 (32%), Positives = 145/339 (42%), Gaps = 38/339 (11%)
Query: 140 GNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAF 199
GN + + +F+G+ L L L + + + F LG LL L+L SN +R L + A
Sbjct: 71 GNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEAL 130
Query: 200 AQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLS 259
LG LR L L N L+ LR TF L +L++L L+ N L +L FQ L R+ L
Sbjct: 131 DGLGSLRRLELEGNALE-ELR-PGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLR 188
Query: 260 LRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLS---------- 309
L N L+ LAPEA GL ALR L L N L LP +L L L+L
Sbjct: 189 LSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEE 248
Query: 310 --------------GNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLD 355
G L AL P F H RL L LR N L L L RL
Sbjct: 249 DGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLR 306
Query: 356 LDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQNGSCA 415
L GN C C+ R L W+ ++ R+ + C+ P LRG+ LD L L+ C
Sbjct: 307 LQGNPLWCGCQARPLLEWL----ARARVRSDGA-CQGPRRLRGEALDALRPWDLR---C- 357
Query: 416 DPSPSASLTADRRRQPLPTAAGEEMTPPAGLAEELPPQP 454
P +A + + + PP G EE P
Sbjct: 358 -PGDAAQEEEELEERAVAGPRAPPRGPPRGPGEERAVAP 395
Score = 115 bits (287), Expect = 2e-25
Identities = 116/380 (30%), Positives = 157/380 (41%), Gaps = 72/380 (18%)
Query: 27 CPERCDC-QHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQL 85
CP C C +H C GL+ VP+ PS +L
Sbjct: 396 CPRACVCVPESRHSSCEGCGLQAVPR--GFPSDTQLL----------------------- 430
Query: 86 RRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISR 145
DL+ N S+ F L L L+L + + L G LA L +L LY + N+++
Sbjct: 431 ---DLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAG 487
Query: 146 LSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKL 205
LS + EG L L L+ N +P A L +L LHL+ N + L + L
Sbjct: 488 LSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRAL 547
Query: 206 RFLNLSANEL-QPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQ 264
R++ LS N + + SL P R L L HL R NQ
Sbjct: 548 RWVYLSGNRITEVSL---GALGPARELEKL----------------HLDR--------NQ 580
Query: 265 LTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPL-HSLEALDLSGNELSALHPATFGH 323
L + A GL AL EL+L GN L L +P+ SL+ L L+ + L + P F
Sbjct: 581 LREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSG 640
Query: 324 LG-RLRELSLRNNALSALSGDIFAASPALYRL---DLDGNGWTCDCRLRGLKRWMGDWHS 379
LG L+ L L+ N L AL A P+L +L DL N + CDC+L L RW+
Sbjct: 641 LGPGLQSLHLQKNQLRAL-----PALPSLSQLELIDLSSNPFHCDCQLLPLHRWL----- 690
Query: 380 QGRLLTVFVQCRHPPALRGK 399
G L V C PP RG+
Sbjct: 691 TGLNLRVGATCATPPNARGQ 710
Score = 88.2 bits (217), Expect = 3e-17
Identities = 85/258 (32%), Positives = 110/258 (42%), Gaps = 34/258 (13%)
Query: 159 KLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPS 218
+L L GN L +P A F + +L +L L + + + AF LG+L LNL++N L+
Sbjct: 66 RLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLREL 125
Query: 219 LRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEA 278
+ A L SL L L N L+ L P F L L L+L N L +L AF GL
Sbjct: 126 PQEALD--GLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLR 183
Query: 279 LRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALS 338
+R LRL S N LS L P L LR LSL +N L
Sbjct: 184 VRWLRL------------------------SHNALSVLAPEALAGLPALRRLSLHHNELQ 219
Query: 339 ALSGDIFAASPALYRLDLDGN-----GWTCDCRLRGLKRWMGDWHS-QGRLLTVFVQC-- 390
AL G + + + L RL+L N G L GL+ + D + Q F C
Sbjct: 220 ALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPR 279
Query: 391 RHPPALRGKYLDYLDDQQ 408
H LRG LD L Q
Sbjct: 280 LHTLDLRGNQLDTLPPLQ 297
Score = 58.5 bits (140), Expect = 2e-08
Identities = 78/273 (28%), Positives = 102/273 (37%), Gaps = 35/273 (12%)
Query: 257 LLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSAL 316
LL LR N + AF GL L L L+ +++L L L L L LS N+L+ L
Sbjct: 429 LLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGL 488
Query: 317 HPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGD 376
A RL L L N + G A P+L+ L L N D
Sbjct: 489 SAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAV--------------D 534
Query: 377 WHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQPLPTAA 436
+ G L ALR YL ++ G+ L DR +
Sbjct: 535 RLAPGDL-------GRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQL------ 581
Query: 437 GEEMTPPAGLAEELPPQPQLQQQGRFLAGVAWDGAARELVGNRSALRLSRRGPGLQQPSP 496
P G E LP +LQ G L + DGA + + RS L GL+Q P
Sbjct: 582 ---REVPTGALEGLPALLELQLSGNPLRALR-DGAFQPV--GRSLQHLFLNSSGLEQICP 635
Query: 497 SVAAAAGPAPQSLDLHKKPQRGRPTRADPALAE 529
+ GP QSL L K R P A P+L++
Sbjct: 636 GAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQ 666
Score = 45.1 bits (105), Expect = 3e-04
Identities = 29/83 (34%), Positives = 42/83 (50%)
Query: 277 EALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNA 336
E + L L+GN L +P A + + L LDL E+ + F LGRL L+L +N
Sbjct: 62 ELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNH 121
Query: 337 LSALSGDIFAASPALYRLDLDGN 359
L L + +L RL+L+GN
Sbjct: 122 LRELPQEALDGLGSLRRLELEGN 144
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 121 bits (304), Expect = 2e-27
Identities = 118/370 (31%), Positives = 164/370 (44%), Gaps = 43/370 (11%)
Query: 18 ALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAF 77
+L PL CP RC C + C LRV P + + H SL N + +
Sbjct: 36 SLQPLPR-ACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQH----LSLQNNQLQELPYN 90
Query: 78 DFHRLGQLRRLDLQYNQIRS--LHPKTFEKLSRLEELYLGNNLLQA-------------- 121
+ RL LR L+L N I S L + FE L++L+ L + +N L
Sbjct: 91 ELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADL 150
Query: 122 -------LAPGTLAPLRKLRILYANGNEISR--LSRGSFEGLESLVKLRLDGNALGALPD 172
+ P T LR +Y + N++S L +F G E++ L L N L LP
Sbjct: 151 AANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPP 210
Query: 173 AVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLS 232
++ L L HL++N I + + A ++ +LR L L N+L S A TF+ L SL
Sbjct: 211 SLPPSLERL---HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLE 267
Query: 233 SLILSANNLQHLGPRIFQHLPR-LGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRL-- 289
L LS N L + LPR L +L L N++ + G LR L L+ N+L
Sbjct: 268 YLDLSHNQL----TTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGS 323
Query: 290 SQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASP 349
S LP L PL L L L GN L + PA RLR L L +N ++AL A+P
Sbjct: 324 SGLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATP 380
Query: 350 ALYRLDLDGN 359
L L+L N
Sbjct: 381 GLTELNLAYN 390
Score = 96.7 bits (239), Expect = 8e-20
Identities = 111/356 (31%), Positives = 147/356 (41%), Gaps = 60/356 (16%)
Query: 37 QHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIR 96
QHL + L V P+ P + L N + I F LR + L NQ+
Sbjct: 125 QHLCVAHNKLSVAPQFL----PRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLS 180
Query: 97 S--LHPKTFE-------------KLS--------RLEELYLGNNLLQALAPGTLAPLRKL 133
+ L P F +LS LE L+L NNL+ + G L+ +L
Sbjct: 181 NAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQL 240
Query: 134 RILYANGNEI--SRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRI 191
R LY N++ S L +F L SL L L N L +P + L LHL NRI
Sbjct: 241 RELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLA---ILHLGRNRI 297
Query: 192 RFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQH 251
R + LR+L L N+L S A PLR L +L L N L + P + +
Sbjct: 298 RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR 357
Query: 252 L---------------------PRLGLLSLRGNQLT--HLAPEAFWGLEALRELRLEGNR 288
L P L L+L N+L + AF L ALR L L GN+
Sbjct: 358 LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ 417
Query: 289 LSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDI 344
L++LP L L +L+ L N+L L P L +LRELSL +N L GDI
Sbjct: 418 LTRLPMGLPTGLRTLQ---LQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV--GDI 468
Score = 38.5 bits (88), Expect = 0.025
Identities = 22/53 (41%), Positives = 31/53 (58%), Gaps = 2/53 (3%)
Query: 85 LRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQA--LAPGTLAPLRKLRI 135
LR L LQ NQ+R L P+ L +L EL L +N L+ + PGT L+ L++
Sbjct: 429 LRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQV 481
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 121 bits (304), Expect = 2e-27
Identities = 118/370 (31%), Positives = 164/370 (44%), Gaps = 43/370 (11%)
Query: 18 ALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAF 77
+L PL CP RC C + C LRV P + + H SL N + +
Sbjct: 38 SLQPLPR-ACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQH----LSLQNNQLQELPYN 92
Query: 78 DFHRLGQLRRLDLQYNQIRS--LHPKTFEKLSRLEELYLGNNLLQA-------------- 121
+ RL LR L+L N I S L + FE L++L+ L + +N L
Sbjct: 93 ELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADL 152
Query: 122 -------LAPGTLAPLRKLRILYANGNEISR--LSRGSFEGLESLVKLRLDGNALGALPD 172
+ P T LR +Y + N++S L +F G E++ L L N L LP
Sbjct: 153 AANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPP 212
Query: 173 AVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLS 232
++ L L HL++N I + + A ++ +LR L L N+L S A TF+ L SL
Sbjct: 213 SLPPSLERL---HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLE 269
Query: 233 SLILSANNLQHLGPRIFQHLPR-LGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRL-- 289
L LS N L + LPR L +L L N++ + G LR L L+ N+L
Sbjct: 270 YLDLSHNQL----TTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGS 325
Query: 290 SQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASP 349
S LP L PL L L L GN L + PA RLR L L +N ++AL A+P
Sbjct: 326 SGLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATP 382
Query: 350 ALYRLDLDGN 359
L L+L N
Sbjct: 383 GLTELNLAYN 392
Score = 96.7 bits (239), Expect = 8e-20
Identities = 111/356 (31%), Positives = 147/356 (41%), Gaps = 60/356 (16%)
Query: 37 QHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIR 96
QHL + L V P+ P + L N + I F LR + L NQ+
Sbjct: 127 QHLCVAHNKLSVAPQFL----PRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLS 182
Query: 97 S--LHPKTFE-------------KLS--------RLEELYLGNNLLQALAPGTLAPLRKL 133
+ L P F +LS LE L+L NNL+ + G L+ +L
Sbjct: 183 NAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQL 242
Query: 134 RILYANGNEI--SRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRI 191
R LY N++ S L +F L SL L L N L +P + L LHL NRI
Sbjct: 243 RELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLA---ILHLGRNRI 299
Query: 192 RFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQH 251
R + LR+L L N+L S A PLR L +L L N L + P + +
Sbjct: 300 RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR 359
Query: 252 L---------------------PRLGLLSLRGNQLT--HLAPEAFWGLEALRELRLEGNR 288
L P L L+L N+L + AF L ALR L L GN+
Sbjct: 360 LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ 419
Query: 289 LSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDI 344
L++LP L L +L+ L N+L L P L +LRELSL +N L GDI
Sbjct: 420 LTRLPMGLPTGLRTLQ---LQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV--GDI 470
Score = 38.5 bits (88), Expect = 0.025
Identities = 22/53 (41%), Positives = 31/53 (58%), Gaps = 2/53 (3%)
Query: 85 LRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQA--LAPGTLAPLRKLRI 135
LR L LQ NQ+R L P+ L +L EL L +N L+ + PGT L+ L++
Sbjct: 431 LRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQV 483
>gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
sapiens]
Length = 522
Score = 121 bits (304), Expect = 2e-27
Identities = 92/303 (30%), Positives = 150/303 (49%), Gaps = 9/303 (2%)
Query: 9 LLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGG 68
+L ++ C + P A CP+ C C+ + L C L P S +L SL
Sbjct: 21 VLCLLGACFQMLPAAPSGCPQLCRCEG-RLLYCEALNLTEAPHNLS-----GLLGLSLRY 74
Query: 69 NFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLA 128
N ++ + A F L QL L L +N I S+ F+KL R++EL L +N + L T
Sbjct: 75 NSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFR 134
Query: 129 PLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLES 188
P+ LR + + N++ L+ F GL L L + NA+ +P +F +L +L +
Sbjct: 135 PMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGY 194
Query: 189 NRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRI 248
N+++ L +N+FA L KL L+L N+L + A F L SL SL L N + + +
Sbjct: 195 NQLKSLARNSFAGLFKLTELHLEHNDLVKV--NFAHFPRLISLHSLCLRRNKVAIVVSSL 252
Query: 249 FQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDL 308
+ L + L GN++ ++ P F + L+ L+L+ NRL+ + +L SL ++ L
Sbjct: 253 -DWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITL 311
Query: 309 SGN 311
+GN
Sbjct: 312 AGN 314
Score = 99.8 bits (247), Expect = 9e-21
Identities = 109/380 (28%), Positives = 161/380 (42%), Gaps = 72/380 (18%)
Query: 134 RILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRF 193
R+LY ++ L L+ L L N+L L F L L +L+L+ N I
Sbjct: 48 RLLYCEALNLTEAPHN----LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICS 103
Query: 194 LGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLP 253
+ +AF +L +++ L LS+N++ TF P+ +L S+ LS N LQ L P +F L
Sbjct: 104 VQGDAFQKLRRVKELTLSSNQITQLPN--TTFRPMPNLRSVDLSYNKLQALAPDLFHGLR 161
Query: 254 RLGLLSLRG------------------------NQLTHLAPEAFWGLEALRELRLEGNRL 289
+L L +R NQL LA +F GL L EL LE N L
Sbjct: 162 KLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDL 221
Query: 290 SQLPTA---LLEPLHS--------------------LEALDLSGNELSALHPATFGHLGR 326
++ A L LHS LE +DLSGNE+ + P F +
Sbjct: 222 VKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPH 281
Query: 327 LRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTV 386
L+ L L +N L+ + I + +L + L GN W C + L W+ ++ QGR
Sbjct: 282 LQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNF--QGR-YDG 338
Query: 387 FVQCRHPPALRGKYLDYLDD----QQLQNGSCADPSPSASLTADRRRQPLPTAAGEEMTP 442
+QC P +G+ D LD ++G A+P+ L+A R ++ P
Sbjct: 339 NLQCASPEYAQGE--DVLDAVYAFHLCEDG--AEPTSGHLLSAVTNR--------SDLGP 386
Query: 443 PAGLAEELPPQPQLQQQGRF 462
PA A L + Q G F
Sbjct: 387 PASSATTLADGGEGQHDGTF 406
Score = 30.0 bits (66), Expect = 9.0
Identities = 22/81 (27%), Positives = 33/81 (40%), Gaps = 1/81 (1%)
Query: 38 HLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRS 97
H LC R +V SSL ++ L GN I + F + L+ L L N++
Sbjct: 236 HSLCLRRN-KVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTY 294
Query: 98 LHPKTFEKLSRLEELYLGNNL 118
+ P+ L + L NL
Sbjct: 295 IEPRILNSWKSLTSITLAGNL 315
>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
sapiens]
Length = 581
Score = 121 bits (303), Expect = 3e-27
Identities = 93/307 (30%), Positives = 146/307 (47%), Gaps = 8/307 (2%)
Query: 6 ALRLLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYS 65
A+ L++ L + AE CP+ C C+ + C ++ L+ +P + S L S
Sbjct: 13 AVALVIAPTVLLTMLSSAERGCPKGCRCEGKM-VYCESQKLQEIPSSISA----GCLGLS 67
Query: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
L N + + F L QL L L +N I ++ F + RL+EL L +N +
Sbjct: 68 LRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNN 127
Query: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185
T P+ LR L + N++ L F GL L+ L L N+L +P +F NL L
Sbjct: 128 TFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLD 187
Query: 186 LESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLG 245
L NRIR L +N FA + +L+ L+L N+ S + A F L SL +L L N + +G
Sbjct: 188 LGYNRIRSLARNVFAGMIRLKELHLEHNQF--SKLNLALFPRLVSLQNLYLQWNKISVIG 245
Query: 246 PRIFQHLPRLGLLSLRGNQLTHLA-PEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLE 304
+ L L L GN++ + P F + L+ L L+ N+L+ + +L+ SL
Sbjct: 246 QTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLN 305
Query: 305 ALDLSGN 311
+ L+GN
Sbjct: 306 DISLAGN 312
Score = 114 bits (285), Expect = 4e-25
Identities = 97/312 (31%), Positives = 141/312 (45%), Gaps = 33/312 (10%)
Query: 112 LYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALP 171
+Y + LQ + A L + Y N + +L F+GL L L LD N + +
Sbjct: 45 VYCESQKLQEIPSSISAGCLGLSLRY---NSLQKLKYNQFKGLNQLTWLYLDHNHISNID 101
Query: 172 DAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSL 231
+ F + L L L SNRI + N F + LR L+LS N+L + F LR L
Sbjct: 102 ENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSL--GSEQFRGLRKL 159
Query: 232 SSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQ 291
SL L +N+L+ + RIFQ L LL L N++ LA F G+ L+EL LE N+ S+
Sbjct: 160 LSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSK 219
Query: 292 LPTALLEPL------------------------HSLEALDLSGNELSALH-PATFGHLGR 326
L AL L SL+ LDLSGNE+ A P+ F +
Sbjct: 220 LNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPN 279
Query: 327 LRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTV 386
L+ L+L +N L+ + +I + +L + L GN W C + L W+ + L
Sbjct: 280 LQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSFKG---LREN 336
Query: 387 FVQCRHPPALRG 398
+ C P L+G
Sbjct: 337 TIICASPKELQG 348
Score = 82.0 bits (201), Expect = 2e-15
Identities = 73/247 (29%), Positives = 112/247 (45%), Gaps = 9/247 (3%)
Query: 114 LGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKL-RLDGNALGALPD 172
+G N+++ L+ +A + +L +S RG +G K+ + L +P
Sbjct: 1 MGFNVIRLLSGSAVALVIAPTVLLTM---LSSAERGCPKGCRCEGKMVYCESQKLQEIPS 57
Query: 173 AVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLS 232
++ A L L L N ++ L N F L +L +L L N + +A F +R L
Sbjct: 58 SISA---GCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENA--FNGIRRLK 112
Query: 233 SLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQL 292
LILS+N + + F+ + L L L NQL L E F GL L L L N L +
Sbjct: 113 ELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTI 172
Query: 293 PTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALY 352
P + + +LE LDL N + +L F + RL+EL L +N S L+ +F +L
Sbjct: 173 PVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQ 232
Query: 353 RLDLDGN 359
L L N
Sbjct: 233 NLYLQWN 239
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,818,546
Number of Sequences: 37866
Number of extensions: 1841074
Number of successful extensions: 13471
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 220
Number of HSP's successfully gapped in prelim test: 480
Number of HSP's that attempted gapping in prelim test: 8943
Number of HSP's gapped (non-prelim): 2561
length of query: 811
length of database: 18,247,518
effective HSP length: 111
effective length of query: 700
effective length of database: 14,044,392
effective search space: 9831074400
effective search space used: 9831074400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.