Search of human proteins with 7662108

Search of human proteins with 7662108

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
         (516 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]            1071   0.0  
gi|23308553 spermatogenesis associated 13 [Homo sapiens]              641   0.0  
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...   621   e-178
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...   604   e-173
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]          205   9e-53
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]          205   9e-53
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...   202   6e-52
gi|71274148 pleckstrin homology domain containing, family G (wit...   131   1e-30
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap...   115   7e-26
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom...   109   5e-24
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom...   109   5e-24
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom...   109   5e-24
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo...   109   5e-24
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ...   109   5e-24
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...   107   2e-23
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]               104   2e-22
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                   103   5e-22
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                   103   5e-22
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ...   102   6e-22
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ...   102   6e-22
gi|55749621 pleckstrin homology domain containing, family G, mem...   100   2e-21
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...    99   7e-21
gi|153791628 MCF.2 cell line derived transforming sequence isofo...    98   2e-20
gi|153791325 MCF.2 cell line derived transforming sequence isofo...    98   2e-20
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...    98   2e-20
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]     97   5e-20
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo...    89   7e-18
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...    89   1e-17
gi|163644325 MCF.2 cell line derived transforming sequence-like ...    88   2e-17
gi|163644323 MCF.2 cell line derived transforming sequence-like ...    88   2e-17

>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
          Length = 516

 Score = 1071 bits (2769), Expect = 0.0
 Identities = 516/516 (100%), Positives = 516/516 (100%)

Query: 1   MTLLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPAS 60
           MTLLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPAS
Sbjct: 1   MTLLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPAS 60

Query: 61  FVRLWVNQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIK 120
           FVRLWVNQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIK
Sbjct: 61  FVRLWVNQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIK 120

Query: 121 HLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEI 180
           HLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEI
Sbjct: 121 HLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEI 180

Query: 181 GPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLL 240
           GPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLL
Sbjct: 181 GPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLL 240

Query: 241 TPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQW 300
           TPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQW
Sbjct: 241 TPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQW 300

Query: 301 QASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDIL 360
           QASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDIL
Sbjct: 301 QASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDIL 360

Query: 361 YYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAF 420
           YYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAF
Sbjct: 361 YYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAF 420

Query: 421 REERKMVQEDEKIGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPLNHGQY 480
           REERKMVQEDEKIGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPLNHGQY
Sbjct: 421 REERKMVQEDEKIGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPLNHGQY 480

Query: 481 LVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK 516
           LVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK
Sbjct: 481 LVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK 516


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score =  641 bits (1654), Expect = 0.0
 Identities = 318/520 (61%), Positives = 395/520 (75%), Gaps = 17/520 (3%)

Query: 4   LITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVR 63
           LI+  ++V AEA+WDHVTM ++EL FKAGDVI+VL+ASNKDWWWG+ +D+E WFPASFVR
Sbjct: 143 LISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVR 202

Query: 64  LWVNQEDEVEEG---PSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIK 120
           L VNQE+  E     PS+ Q+     +    C     +N+ QMR NVI EIM TER YIK
Sbjct: 203 LRVNQEELSENSSSTPSEEQDEEASQSRHRHC-----ENKQQMRTNVIREIMDTERVYIK 257

Query: 121 HLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEI 180
           HL+DICEGY++QCRK   MF+  QL  IFGNIEDIY+FQ  F++DLEKQYN ++PHLSEI
Sbjct: 258 HLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEI 317

Query: 181 GPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLL 240
           G CFL++Q+GF IYSEYCNNH  AC+EL+ LMK  +Y+HFFEACRLLQQMIDIAIDGFLL
Sbjct: 318 GSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLL 377

Query: 241 TPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQW 300
           TPVQKICKYPLQLAELLKYT Q+H DY  + AA   M+NV   INERKR+LE+IDKIA+W
Sbjct: 378 TPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARW 437

Query: 301 QASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDIL 360
           Q S++ WEG DILDRSSELI++GE+  I +  G++QQR FFLFDHQ+V CKKDL+RRD+L
Sbjct: 438 QVSIVGWEGLDILDRSSELIHSGELTKITK-QGKSQQRTFFLFDHQLVSCKKDLLRRDML 496

Query: 361 YYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAF 420
           YYKGR+DMD+ E+VD+ DGRD D N+S+KNAFKL ++ T+E++LF AKK E+K RWL+A 
Sbjct: 497 YYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQAC 556

Query: 421 REERKMVQEDEKIGFEISENQKRQAAMTVRKV--PKQKGVNSARSVPPSYPPPQ--DPLN 476
            +ER+ VQED+++G EISENQK+ A +  +K    K KG N      P  PP Q   P++
Sbjct: 557 ADERRRVQEDKEMGMEISENQKKLAMLNAQKAGHGKSKGYNRC----PVAPPHQGLHPIH 612

Query: 477 HGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK 516
                +P  + Q QVF   EPKR  S FW  F+RLTPF+K
Sbjct: 613 QRHITMPTSVPQQQVFGLAEPKRKSSLFWHTFNRLTPFRK 652


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score =  621 bits (1601), Expect = e-178
 Identities = 304/518 (58%), Positives = 383/518 (73%), Gaps = 22/518 (4%)

Query: 4   LITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVR 63
           LI+  S+V AEA+WDHVTM ++EL FKAGDVI+V+DA+N++WWWG++ D EGWFPASFVR
Sbjct: 190 LISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVR 249

Query: 64  LWVNQEDEVEE-----GPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHY 118
           L VNQ++  ++     G S  ++G  +  S          ++DQMR NVINEI+STER Y
Sbjct: 250 LRVNQDEPADDDAPLAGNSGAEDGGAEAQS----------SKDQMRTNVINEILSTERDY 299

Query: 119 IKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLS 178
           IKHL+DICEGY++QCRKR DMFS+EQL+ IFGNIEDIYR Q  FV+ LE+++N + PHLS
Sbjct: 300 IKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLS 359

Query: 179 EIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGF 238
           E+G CFLEHQ  F IYSEYCNNH +AC+ELS+L K S+Y +FFEACRLLQ+MIDI++DGF
Sbjct: 360 ELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGF 419

Query: 239 LLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIA 298
           LLTPVQKICKYPLQLAELLKYT   H D++ V AAL  M+NV Q INERKRRLENIDKIA
Sbjct: 420 LLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIA 479

Query: 299 QWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRD 358
           QWQ+S+ DWEGED+L RSSELIY+GE+  + QP  ++QQR+FFLFDHQ++ CKKDL+RRD
Sbjct: 480 QWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRD 539

Query: 359 ILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLR 418
           +LYYKGR+DMD  EVVD+EDG+D D +VS+KNAF+LH   T + HL   +K E+K RWL+
Sbjct: 540 VLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLK 599

Query: 419 AFREERKMVQEDEKIGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPLNHG 478
           AF  ER+ VQ D++ GF I+E Q++QA +   K             P +   P       
Sbjct: 600 AFAREREQVQLDQETGFSITELQRKQAMLNASK-------QQVTGKPKAVGRPCYLTRQK 652

Query: 479 QYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK 516
              +P    Q QV    EP+R  S FW + SRL PF+K
Sbjct: 653 HPALPSNRPQQQVLVLAEPRRKPSTFWHSISRLAPFRK 690


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score =  604 bits (1558), Expect = e-173
 Identities = 295/492 (59%), Positives = 376/492 (76%), Gaps = 18/492 (3%)

Query: 4   LITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVR 63
           LI+  S+V AEA+WDHVTM ++EL FKAGDVI+V+DA+N++WWWG++ D EGWFPASFVR
Sbjct: 190 LISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVR 249

Query: 64  LWVNQEDEVEE-----GPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHY 118
           L VNQ++  ++     G S  ++G  +  S          ++DQMR NVINEI+STER Y
Sbjct: 250 LRVNQDEPADDDAPLAGNSGAEDGGAEAQS----------SKDQMRTNVINEILSTERDY 299

Query: 119 IKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLS 178
           IKHL+DICEGY++QCRKR DMFS+EQL+ IFGNIEDIYR Q  FV+ LE+++N + PHLS
Sbjct: 300 IKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLS 359

Query: 179 EIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGF 238
           E+G CFLEHQ  F IYSEYCNNH +AC+ELS+L K S+Y +FFEACRLLQ+MIDI++DGF
Sbjct: 360 ELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGF 419

Query: 239 LLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIA 298
           LLTPVQKICKYPLQLAELLKYT   H D++ V AAL  M+NV Q INERKRRLENIDKIA
Sbjct: 420 LLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIA 479

Query: 299 QWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRD 358
           QWQ+S+ DWEGED+L RSSELIY+GE+  + QP  ++QQR+FFLFDHQ++ CKKDL+RRD
Sbjct: 480 QWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRD 539

Query: 359 ILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLR 418
           +LYYKGR+DMD  EVVD+EDG+D D +VS+KNAF+LH   T + HL   +K E+K RWL+
Sbjct: 540 VLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLK 599

Query: 419 AFREERKMVQEDEKIGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPLNHG 478
           AF  ER+ VQ D++ GF I+E Q++QA +      KQ+     +    + PPP+ P  + 
Sbjct: 600 AFAREREQVQLDQETGFSITELQRKQAML---NASKQQVTGKPKGRRTAAPPPRLPGPYP 656

Query: 479 QYLVPDGIAQSQ 490
             ++P    QSQ
Sbjct: 657 ADIIPFSEPQSQ 668


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score =  205 bits (521), Expect = 9e-53
 Identities = 131/382 (34%), Positives = 209/382 (54%), Gaps = 29/382 (7%)

Query: 95  RPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYL---KQCRKRR--DMFSDEQLKVIF 149
           + L+ + ++R  V++E+  TER Y+  L+ +   +L    QC   +     ++E +K++F
Sbjct: 15  KDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLF 74

Query: 150 GNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELS 209
            NIEDI      F++ +E+  + +     E+G CFL  +D F IY EYC+NH  A   L 
Sbjct: 75  SNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLL 134

Query: 210 KLMKDSRYQHFFEACRLL--QQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDY 267
           +L K    + F   C LL  ++  D+ ++G+L+TP+Q+ICKYPL L ELLK T + HSDY
Sbjct: 135 ELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDY 194

Query: 268 RYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAW 327
             V  AL  M+ V   INE KR++E ++ + +WQ+ +  WEG +I D  +E++  G +  
Sbjct: 195 AAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLK 254

Query: 328 IYQPYGRNQQRVFFLFDHQMVLCKKDLIR---------RDILYYKGRIDMDKYEVVDIED 378
           I    G  Q+RVFFLFD+ +V CK+   R              ++GRI+ +  EV +++D
Sbjct: 255 ISS--GNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDD 312

Query: 379 GRDDDFNVS---MKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGF 435
           G   DF+ S   + N +K+HN    +  +  AK  EEK  W  A  +ER+  ++  K+G 
Sbjct: 313 G-TADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERER-RKGLKLGM 370

Query: 436 E------ISENQKRQAAMTVRK 451
           E      ISE  ++   M  R+
Sbjct: 371 EQDTWVMISEQGEKLYKMMCRQ 392


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score =  205 bits (521), Expect = 9e-53
 Identities = 131/382 (34%), Positives = 209/382 (54%), Gaps = 29/382 (7%)

Query: 95  RPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYL---KQCRKRR--DMFSDEQLKVIF 149
           + L+ + ++R  V++E+  TER Y+  L+ +   +L    QC   +     ++E +K++F
Sbjct: 15  KDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLF 74

Query: 150 GNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELS 209
            NIEDI      F++ +E+  + +     E+G CFL  +D F IY EYC+NH  A   L 
Sbjct: 75  SNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLL 134

Query: 210 KLMKDSRYQHFFEACRLL--QQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDY 267
           +L K    + F   C LL  ++  D+ ++G+L+TP+Q+ICKYPL L ELLK T + HSDY
Sbjct: 135 ELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDY 194

Query: 268 RYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAW 327
             V  AL  M+ V   INE KR++E ++ + +WQ+ +  WEG +I D  +E++  G +  
Sbjct: 195 AAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLK 254

Query: 328 IYQPYGRNQQRVFFLFDHQMVLCKKDLIR---------RDILYYKGRIDMDKYEVVDIED 378
           I    G  Q+RVFFLFD+ +V CK+   R              ++GRI+ +  EV +++D
Sbjct: 255 ISS--GNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDD 312

Query: 379 GRDDDFNVS---MKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGF 435
           G   DF+ S   + N +K+HN    +  +  AK  EEK  W  A  +ER+  ++  K+G 
Sbjct: 313 G-TADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERER-RKGLKLGM 370

Query: 436 E------ISENQKRQAAMTVRK 451
           E      ISE  ++   M  R+
Sbjct: 371 EQDTWVMISEQGEKLYKMMCRQ 392


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score =  202 bits (514), Expect = 6e-52
 Identities = 124/365 (33%), Positives = 196/365 (53%), Gaps = 26/365 (7%)

Query: 95  RPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKR-----RDMFSDEQLKVIF 149
           R  + + ++R  V+NEI+ TER Y+  L+ +   +L + R+          ++E +KV+F
Sbjct: 41  RESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLF 100

Query: 150 GNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELS 209
            NIEDI      F+  LE   + +     E+G  FL+ +D F +Y EYC+NH  A   L 
Sbjct: 101 SNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLV 160

Query: 210 KLMKDSRYQHFFEACRLL--QQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDY 267
           +L K    + F  +C LL  ++  DI ++G+LL+P+Q+ICKYPL L EL K T   H D+
Sbjct: 161 ELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDH 220

Query: 268 RYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAW 327
             V +AL  M+ V   INE KR++E ++ + Q Q+ +  WEG ++ D  ++L+  G +  
Sbjct: 221 PAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLK 280

Query: 328 IYQPYGRNQQRVFFLFDHQMVLCKK--------------DLIRRDILYYKGRIDMDKYEV 373
           I    G  Q+R FFLFD+ +V CK+                I   +  ++GRI+ +  EV
Sbjct: 281 I--SAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEV 338

Query: 374 VDIEDGRDD--DFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDE 431
            ++EDG  D      ++ N +K+HN    +  +  AK  EEK +WL A   ER+  +E  
Sbjct: 339 ENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQ-RESL 397

Query: 432 KIGFE 436
           K+G E
Sbjct: 398 KLGME 402


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score =  131 bits (330), Expect = 1e-30
 Identities = 96/314 (30%), Positives = 153/314 (48%), Gaps = 25/314 (7%)

Query: 107 VINEIMSTERHYIKHLKDICEGYLKQCRKRRDM-FSDEQLKVIFGNIEDIYRFQMGFVRD 165
           V+ EI+ TER Y++ LK I E YL   R +  +    E+   +FGNI+DIY F    ++D
Sbjct: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQD 176

Query: 166 LEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACR 225
           LE   N  DP    I  CF+   + F IY++YC N+  +   L++ M++     FF   R
Sbjct: 177 LENCEN--DP--VAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFF---R 229

Query: 226 LLQQMI--DIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQ 283
             Q+ +   + +  +LL PVQ+I KY L L E+  +  +D   Y  V  A+  M+ V   
Sbjct: 230 ERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWH 289

Query: 284 INERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLF 343
           IN+ KR+ E+  ++ + Q+ + +W+G D L    EL+  G     ++      +R  FLF
Sbjct: 290 INDMKRKHEHAVRLQEIQSLLTNWKGPD-LTSYGELVLEG----TFRIQRAKNERTLFLF 344

Query: 344 DHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIH 403
           D  +++ KK   R D   YK  I      +V++       F+V        H K  +  H
Sbjct: 345 DKLLLITKK---RDDTFTYKAHILCGNLMLVEVIPKEPLSFSV-------FHYKNPKLQH 394

Query: 404 LFFAKKLEEKIRWL 417
              AK  ++K  W+
Sbjct: 395 TVQAKSQQDKRLWV 408


>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
          Length = 1591

 Score =  115 bits (289), Expect = 7e-26
 Identities = 87/299 (29%), Positives = 140/299 (46%), Gaps = 21/299 (7%)

Query: 73   EEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQ 132
            E  PSD      D     L   R L + D++R  VI E++ TER Y+K L  + E YLK 
Sbjct: 1011 EMNPSDQSPSPQDSTGPQLATMRQLSDADKLR-KVICELLETERTYVKDLNCLMERYLKP 1069

Query: 133  CRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVR----------DLEKQYNNDD--PHLSEI 180
             +K   +  DE L V+FGN+ ++  FQ+ F++          DLEK    D     L  +
Sbjct: 1070 LQKETFLTQDE-LDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSL 1128

Query: 181  GPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLL 240
            G  FL + D F +YS +C +H      L K   D+ ++ F +A    QQ     ++ +L+
Sbjct: 1129 GGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSS-TLESYLI 1187

Query: 241  TPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQW 300
             P+Q+I KYPL L EL   T  +  ++ ++  A+  M  V   INE ++  E    +   
Sbjct: 1188 KPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQ 1247

Query: 301  QASVLDWEGEDILDRS-SELIYTGEMAWIYQP-----YGRNQQRVFFLFDHQMVLCKKD 353
              +    E +++ D S  +L+    + W+  P     + +  +   F+F   +VL  KD
Sbjct: 1248 LIAEQTGEKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKD 1306


>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
           sapiens]
          Length = 646

 Score =  109 bits (273), Expect = 5e-24
 Identities = 96/405 (23%), Positives = 170/405 (41%), Gaps = 31/405 (7%)

Query: 26  ELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHL- 84
           EL+F  GDVI V       WW G ++   GWFP+++VR     E +  E P   ++G L 
Sbjct: 24  ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR-----EVKASEKPVSPKSGTLK 78

Query: 85  --DPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSD 142
                 D   + +   N       V+  I+ TE  Y K L+ +   YL+   +  +  S 
Sbjct: 79  SPPKGFDTTAINKSYYN------VVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSS 131

Query: 143 EQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYCNNH 201
             +  + GN+E+I  FQ   V+ LE+     +     +G CFL        +Y  YC NH
Sbjct: 132 ANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANH 190

Query: 202 LDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTA 261
             A   L++         F E        I +   G L  P  ++ KYP  L EL ++  
Sbjct: 191 PSAVNVLTE--HSEELGEFMETKGASSPGILVLTTG-LSKPFMRLDKYPTLLKELERHME 247

Query: 262 QDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIY 321
             H+D + +  ++A  +N++ Q  E ++R E   ++     ++ +WEG+DI      + Y
Sbjct: 248 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDI-KTLGNVTY 304

Query: 322 TGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRD 381
             ++           +R   LF + +++      R     Y+G++      +  +ED  +
Sbjct: 305 MSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSEN 363

Query: 382 DDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKM 426
                  +NAF++     E I L      ++   W+   +++ K+
Sbjct: 364 H------RNAFEISGSMIERI-LVSCNNQQDLQEWVEHLQKQTKV 401


>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
           sapiens]
          Length = 753

 Score =  109 bits (273), Expect = 5e-24
 Identities = 96/405 (23%), Positives = 170/405 (41%), Gaps = 31/405 (7%)

Query: 26  ELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHL- 84
           EL+F  GDVI V       WW G ++   GWFP+++VR     E +  E P   ++G L 
Sbjct: 152 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR-----EVKASEKPVSPKSGTLK 206

Query: 85  --DPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSD 142
                 D   + +   N       V+  I+ TE  Y K L+ +   YL+   +  +  S 
Sbjct: 207 SPPKGFDTTAINKSYYN------VVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSS 259

Query: 143 EQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYCNNH 201
             +  + GN+E+I  FQ   V+ LE+     +     +G CFL        +Y  YC NH
Sbjct: 260 ANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANH 318

Query: 202 LDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTA 261
             A   L++         F E        I +   G L  P  ++ KYP  L EL ++  
Sbjct: 319 PSAVNVLTE--HSEELGEFMETKGASSPGILVLTTG-LSKPFMRLDKYPTLLKELERHME 375

Query: 262 QDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIY 321
             H+D + +  ++A  +N++ Q  E ++R E   ++     ++ +WEG+DI      + Y
Sbjct: 376 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDI-KTLGNVTY 432

Query: 322 TGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRD 381
             ++           +R   LF + +++      R     Y+G++      +  +ED  +
Sbjct: 433 MSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSEN 491

Query: 382 DDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKM 426
                  +NAF++     E I L      ++   W+   +++ K+
Sbjct: 492 H------RNAFEISGSMIERI-LVSCNNQQDLQEWVEHLQKQTKV 529


>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
           sapiens]
          Length = 803

 Score =  109 bits (273), Expect = 5e-24
 Identities = 96/405 (23%), Positives = 170/405 (41%), Gaps = 31/405 (7%)

Query: 26  ELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHL- 84
           EL+F  GDVI V       WW G ++   GWFP+++VR     E +  E P   ++G L 
Sbjct: 202 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR-----EVKASEKPVSPKSGTLK 256

Query: 85  --DPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSD 142
                 D   + +   N       V+  I+ TE  Y K L+ +   YL+   +  +  S 
Sbjct: 257 SPPKGFDTTAINKSYYN------VVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSS 309

Query: 143 EQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYCNNH 201
             +  + GN+E+I  FQ   V+ LE+     +     +G CFL        +Y  YC NH
Sbjct: 310 ANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANH 368

Query: 202 LDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTA 261
             A   L++         F E        I +   G L  P  ++ KYP  L EL ++  
Sbjct: 369 PSAVNVLTE--HSEELGEFMETKGASSPGILVLTTG-LSKPFMRLDKYPTLLKELERHME 425

Query: 262 QDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIY 321
             H+D + +  ++A  +N++ Q  E ++R E   ++     ++ +WEG+DI      + Y
Sbjct: 426 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDI-KTLGNVTY 482

Query: 322 TGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRD 381
             ++           +R   LF + +++      R     Y+G++      +  +ED  +
Sbjct: 483 MSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSEN 541

Query: 382 DDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKM 426
                  +NAF++     E I L      ++   W+   +++ K+
Sbjct: 542 H------RNAFEISGSMIERI-LVSCNNQQDLQEWVEHLQKQTKV 579


>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
           sapiens]
          Length = 782

 Score =  109 bits (273), Expect = 5e-24
 Identities = 96/405 (23%), Positives = 170/405 (41%), Gaps = 31/405 (7%)

Query: 26  ELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHL- 84
           EL+F  GDVI V       WW G ++   GWFP+++VR     E +  E P   ++G L 
Sbjct: 181 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR-----EVKASEKPVSPKSGTLK 235

Query: 85  --DPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSD 142
                 D   + +   N       V+  I+ TE  Y K L+ +   YL+   +  +  S 
Sbjct: 236 SPPKGFDTTAINKSYYN------VVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSS 288

Query: 143 EQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYCNNH 201
             +  + GN+E+I  FQ   V+ LE+     +     +G CFL        +Y  YC NH
Sbjct: 289 ANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANH 347

Query: 202 LDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTA 261
             A   L++         F E        I +   G L  P  ++ KYP  L EL ++  
Sbjct: 348 PSAVNVLTE--HSEELGEFMETKGASSPGILVLTTG-LSKPFMRLDKYPTLLKELERHME 404

Query: 262 QDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIY 321
             H+D + +  ++A  +N++ Q  E ++R E   ++     ++ +WEG+DI      + Y
Sbjct: 405 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDI-KTLGNVTY 461

Query: 322 TGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRD 381
             ++           +R   LF + +++      R     Y+G++      +  +ED  +
Sbjct: 462 MSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSEN 520

Query: 382 DDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKM 426
                  +NAF++     E I L      ++   W+   +++ K+
Sbjct: 521 H------RNAFEISGSMIERI-LVSCNNQQDLQEWVEHLQKQTKV 558


>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
           sapiens]
          Length = 646

 Score =  109 bits (273), Expect = 5e-24
 Identities = 96/405 (23%), Positives = 170/405 (41%), Gaps = 31/405 (7%)

Query: 26  ELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHL- 84
           EL+F  GDVI V       WW G ++   GWFP+++VR     E +  E P   ++G L 
Sbjct: 24  ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR-----EVKASEKPVSPKSGTLK 78

Query: 85  --DPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSD 142
                 D   + +   N       V+  I+ TE  Y K L+ +   YL+   +  +  S 
Sbjct: 79  SPPKGFDTTAINKSYYN------VVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSS 131

Query: 143 EQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYCNNH 201
             +  + GN+E+I  FQ   V+ LE+     +     +G CFL        +Y  YC NH
Sbjct: 132 ANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANH 190

Query: 202 LDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTA 261
             A   L++         F E        I +   G L  P  ++ KYP  L EL ++  
Sbjct: 191 PSAVNVLTE--HSEELGEFMETKGASSPGILVLTTG-LSKPFMRLDKYPTLLKELERHME 247

Query: 262 QDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIY 321
             H+D + +  ++A  +N++ Q  E ++R E   ++     ++ +WEG+DI      + Y
Sbjct: 248 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDI-KTLGNVTY 304

Query: 322 TGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRD 381
             ++           +R   LF + +++      R     Y+G++      +  +ED  +
Sbjct: 305 MSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSEN 363

Query: 382 DDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKM 426
                  +NAF++     E I L      ++   W+   +++ K+
Sbjct: 364 H------RNAFEISGSMIERI-LVSCNNQQDLQEWVEHLQKQTKV 401


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score =  107 bits (268), Expect = 2e-23
 Identities = 118/401 (29%), Positives = 165/401 (41%), Gaps = 43/401 (10%)

Query: 83  HLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDM-FS 141
           HL P      +G P   R      V  EI+ TER Y++ L+ I E YL        +  S
Sbjct: 88  HLSP------VGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLS 141

Query: 142 DEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNH 201
            EQ+  +F NIEDIY F    + DLE     +      I  CF++  + F IY+ YC N+
Sbjct: 142 VEQVGTLFANIEDIYEFSSELLEDLE-----NSSSAGGIAECFVQRSEDFDIYTLYCMNY 196

Query: 202 LDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTA 261
             +   L +L        + +  R  Q    + +  FLL PVQ+I KY L L EL K+ A
Sbjct: 197 PSSLALLRELSLSPPAALWLQE-RQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWA 255

Query: 262 Q--DHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSEL 319
           +         V  A+  M  V   IN+ KR+ E+  ++ + Q  +  W G + L    EL
Sbjct: 256 EGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPE-LSAFGEL 314

Query: 320 IYTGEM--AWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILY-YKGRIDMDKYEVVDI 376
           +  G         P  R  +R+ FLF   +++ K    RR + Y YKG I      V   
Sbjct: 315 VLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAK----RRGLEYTYKGHIFCCNLSV--S 368

Query: 377 EDGRDD-DFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFRE---ERKMVQEDEK 432
           E  RD   F VS     K         HL  AK  EEK  W+   +    E        K
Sbjct: 369 ESPRDPLGFKVSDLTIPK-------HRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAK 421

Query: 433 IGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQD 473
               + EN       ++   PK K V    + P   P P+D
Sbjct: 422 AKQVLLEN-------SLHCAPKSKPVLEPLTPPLGSPRPRD 455


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score =  104 bits (259), Expect = 2e-22
 Identities = 68/292 (23%), Positives = 145/292 (49%), Gaps = 17/292 (5%)

Query: 16   VWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEG 75
            ++D+    + ELAF  G +I VL+  + DWW G+++ + G FP+++V+L  +  D  ++ 
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDM-DPSQQW 1221

Query: 76   PSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRK 135
             SD+             L   L   ++ R   I+E++ TE +Y+  L+ + E + K   +
Sbjct: 1222 CSDLH------------LLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLME 1269

Query: 136  RRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLE--KQYNNDDPHLSEIGPCFLEHQDGFWI 193
              ++ +++++ +IF N +++    +  ++ L   K+ + +   +  IG            
Sbjct: 1270 S-ELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQP 1328

Query: 194  YSEYCNNHLD-ACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQ 252
            Y  +C+  L+ A +   K  +   ++ F +   +  +   + +  F+L P+Q++ +YPL 
Sbjct: 1329 YIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLI 1388

Query: 253  LAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASV 304
            +  +L+ T ++H D+ ++  AL     +  Q+NE  R  EN D++   QA V
Sbjct: 1389 IKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHV 1440



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 19/54 (35%), Positives = 33/54 (61%), Gaps = 1/54 (1%)

Query: 11  VSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRL 64
           + A+A++      +  L F   DVI VL+  +  WW+G++  ++GWFP S+V+L
Sbjct: 916 LQAQALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKL 968



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 22/58 (37%), Positives = 34/58 (58%), Gaps = 4/58 (6%)

Query: 10   IVSAE---AVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRL 64
            +VS E   A++ + +    +L F+ GDVI V      DWW G + D+ G FP+++VRL
Sbjct: 1001 VVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDG-DWWTGTVGDKAGVFPSNYVRL 1057



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 14/57 (24%), Positives = 27/57 (47%), Gaps = 5/57 (8%)

Query: 13   AEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDD-----EEGWFPASFVRL 64
            A+ +  +      +L    G +I +   +   WW G++       + GWFPA++V+L
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKL 1135



 Score = 30.0 bits (66), Expect = 5.3
 Identities = 15/59 (25%), Positives = 31/59 (52%), Gaps = 7/59 (11%)

Query: 10  IVSAEAVWDHVTMANRELAFKAGDVIKV----LDASNKD---WWWGQIDDEEGWFPASF 61
           +V   A++   + ++ E+  + GD++ V    +D S      W  G++  + GWFPA++
Sbjct: 742 VVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANY 800


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score =  103 bits (256), Expect = 5e-22
 Identities = 71/293 (24%), Positives = 141/293 (48%), Gaps = 17/293 (5%)

Query: 15   AVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEE 74
            A++D+      EL+F  G +I V++  + DWW G+I+   G FP+++V++     D  ++
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKM-TTDSDPSQQ 1165

Query: 75   GPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCR 134
              +D+Q   LD           +Q  ++ R   I+E++ TE  Y+  L+ + E + K+  
Sbjct: 1166 WCADLQT--LDT----------MQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1213

Query: 135  KRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLE--KQYNNDDPHLSEIGPCFLEHQDGFW 192
            +     ++ ++ +IF N +++       ++ L   K+   +   +  IG           
Sbjct: 1214 ES-GFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQ 1272

Query: 193  IYSEYCNNHLD-ACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPL 251
             Y  +C+  L+ A +   K  +D+ ++ F +      +   + +  FLL P+Q+I +YPL
Sbjct: 1273 AYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPL 1332

Query: 252  QLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASV 304
             +  +L+ T + H+D+  +  AL     +  Q+NE  R  EN D++   QA V
Sbjct: 1333 LIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHV 1385



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 20/64 (31%), Positives = 35/64 (54%), Gaps = 1/64 (1%)

Query: 11  VSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQED 70
           + A+A+       +  L F   D+I VL+   ++WW+G++    GWFP S+V++    E 
Sbjct: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLE-QQENWWFGEVHGGRGWFPKSYVKIIPGSEV 932

Query: 71  EVEE 74
           + EE
Sbjct: 933 KREE 936



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 19/73 (26%), Positives = 36/73 (49%), Gaps = 2/73 (2%)

Query: 6   TGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDAS--NKDWWWGQIDDEEGWFPASFVR 63
           T   +V+  A++      + E++F +GD+I+V + +     W +G      GWFP ++V 
Sbjct: 728 TASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 787

Query: 64  LWVNQEDEVEEGP 76
              + E+E    P
Sbjct: 788 KMPSSENEKAVSP 800



 Score = 33.5 bits (75), Expect = 0.48
 Identities = 15/49 (30%), Positives = 27/49 (55%), Gaps = 1/49 (2%)

Query: 15   AVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVR 63
            A++ + ++   +L F  G+ I V      +WW G I D  G FP+++V+
Sbjct: 961  ALYPYSSVEPGDLTFTEGEEILVTQKDG-EWWTGSIGDRSGIFPSNYVK 1008


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score =  103 bits (256), Expect = 5e-22
 Identities = 71/293 (24%), Positives = 141/293 (48%), Gaps = 17/293 (5%)

Query: 15   AVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEE 74
            A++D+      EL+F  G +I V++  + DWW G+I+   G FP+++V++     D  ++
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKM-TTDSDPSQQ 1192

Query: 75   GPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCR 134
              +D+Q   LD           +Q  ++ R   I+E++ TE  Y+  L+ + E + K+  
Sbjct: 1193 WCADLQT--LDT----------MQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1240

Query: 135  KRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLE--KQYNNDDPHLSEIGPCFLEHQDGFW 192
            +     ++ ++ +IF N +++       ++ L   K+   +   +  IG           
Sbjct: 1241 ES-GFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQ 1299

Query: 193  IYSEYCNNHLD-ACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPL 251
             Y  +C+  L+ A +   K  +D+ ++ F +      +   + +  FLL P+Q+I +YPL
Sbjct: 1300 AYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPL 1359

Query: 252  QLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASV 304
             +  +L+ T + H+D+  +  AL     +  Q+NE  R  EN D++   QA V
Sbjct: 1360 LIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHV 1412



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 20/64 (31%), Positives = 35/64 (54%), Gaps = 1/64 (1%)

Query: 11  VSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQED 70
           + A+A+       +  L F   D+I VL+   ++WW+G++    GWFP S+V++    E 
Sbjct: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLE-QQENWWFGEVHGGRGWFPKSYVKIIPGSEV 959

Query: 71  EVEE 74
           + EE
Sbjct: 960 KREE 963



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 19/73 (26%), Positives = 36/73 (49%), Gaps = 2/73 (2%)

Query: 6   TGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDAS--NKDWWWGQIDDEEGWFPASFVR 63
           T   +V+  A++      + E++F +GD+I+V + +     W +G      GWFP ++V 
Sbjct: 755 TASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814

Query: 64  LWVNQEDEVEEGP 76
              + E+E    P
Sbjct: 815 KMPSSENEKAVSP 827



 Score = 33.5 bits (75), Expect = 0.48
 Identities = 15/49 (30%), Positives = 27/49 (55%), Gaps = 1/49 (2%)

Query: 15   AVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVR 63
            A++ + ++   +L F  G+ I V      +WW G I D  G FP+++V+
Sbjct: 988  ALYPYSSVEPGDLTFTEGEEILVTQKDG-EWWTGSIGDRSGIFPSNYVK 1035


>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
           [Homo sapiens]
          Length = 626

 Score =  102 bits (255), Expect = 6e-22
 Identities = 78/299 (26%), Positives = 144/299 (48%), Gaps = 29/299 (9%)

Query: 74  EGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQC 133
           EGP + Q+    P      L R L + D++R  VI E++ TE+ Y+K L  + E YL+  
Sbjct: 2   EGPRENQDPPPRP------LARHLSDADRLR-KVIQELVDTEKSYVKDLSCLFELYLEPL 54

Query: 134 RKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLE------KQYNN-DDPH-----LSEIG 181
           +    +  DE ++ +FG++ ++  FQ  F+  LE        +N  + P      L  +G
Sbjct: 55  QNETFLTQDE-MESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLG 113

Query: 182 PCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLT 241
             FL + D F +YS +C NH+     L +   D  ++ F +A    +Q     ++ +L+ 
Sbjct: 114 GSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSS-TLESYLIK 172

Query: 242 PVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQ 301
           PVQ++ KYPL L EL+  T Q+  ++ ++  AL  M  V   INE ++  E+   +    
Sbjct: 173 PVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQL 232

Query: 302 ASVLDWEGEDILDRS-SELIYTGEMAWIYQPY------GRNQQRVFFLFDHQMVLCKKD 353
            +      +++ + S  EL+    ++W+  P+       ++ +   F+F   ++L  K+
Sbjct: 233 VAEQSGTEKEVTELSMGELLMHSTVSWL-NPFLSLGKARKDLELTVFVFKRAVILVYKE 290


>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
            sapiens]
          Length = 1701

 Score =  102 bits (255), Expect = 6e-22
 Identities = 78/299 (26%), Positives = 144/299 (48%), Gaps = 29/299 (9%)

Query: 74   EGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQC 133
            EGP + Q+    P      L R L + D++R  VI E++ TE+ Y+K L  + E YL+  
Sbjct: 1077 EGPRENQDPPPRP------LARHLSDADRLR-KVIQELVDTEKSYVKDLSCLFELYLEPL 1129

Query: 134  RKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLE------KQYNN-DDPH-----LSEIG 181
            +    +  DE ++ +FG++ ++  FQ  F+  LE        +N  + P      L  +G
Sbjct: 1130 QNETFLTQDE-MESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLG 1188

Query: 182  PCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLT 241
              FL + D F +YS +C NH+     L +   D  ++ F +A    +Q     ++ +L+ 
Sbjct: 1189 GSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSS-TLESYLIK 1247

Query: 242  PVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQ 301
            PVQ++ KYPL L EL+  T Q+  ++ ++  AL  M  V   INE ++  E+   +    
Sbjct: 1248 PVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQL 1307

Query: 302  ASVLDWEGEDILDRS-SELIYTGEMAWIYQPY------GRNQQRVFFLFDHQMVLCKKD 353
             +      +++ + S  EL+    ++W+  P+       ++ +   F+F   ++L  K+
Sbjct: 1308 VAEQSGTEKEVTELSMGELLMHSTVSWL-NPFLSLGKARKDLELTVFVFKRAVILVYKE 1365


>gi|55749621 pleckstrin homology domain containing, family G, member
           3 [Homo sapiens]
          Length = 1163

 Score =  100 bits (250), Expect = 2e-21
 Identities = 72/227 (31%), Positives = 118/227 (51%), Gaps = 19/227 (8%)

Query: 191 FWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYP 250
           F IY++YCNN+ ++   L++ M+D +   FF   + L Q   + +  +LL PVQ+I KY 
Sbjct: 121 FDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQH-SLPLGSYLLKPVQRILKYH 179

Query: 251 LQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGE 310
           L L E+ K+  ++   +  V  A+  M  V   IN+ KRR E+  ++ + Q+ +++W+G 
Sbjct: 180 LLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGP 239

Query: 311 DILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDK 370
           D L    EL+  G     ++ +    +R FFLFD  +++ KK   R D   YKG I    
Sbjct: 240 D-LTTYGELVLEG----TFRVHRVRNERTFFLFDKTLLITKK---RGDHFVYKGNIPCS- 290

Query: 371 YEVVDIEDGRDD-DFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRW 416
             ++ IE  RD   F V+       H K +++ +   AK +EEK  W
Sbjct: 291 -SLMLIESTRDSLCFTVT-------HYKHSKQQYSIQAKTVEEKRNW 329



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 33/153 (21%), Positives = 58/153 (37%), Gaps = 20/153 (13%)

Query: 82  GHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDI------------CEGY 129
           G L P +     G P  ++      V+ EI+ TER Y++ L+ I            C  Y
Sbjct: 73  GPLSPFNSRAAAG-PAHHKLSYLGRVVREIVETERMYVQDLRSIVESQEFDIYTQYCNNY 131

Query: 130 LKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPH---LSEIGPCFLE 186
                   +   D+Q    F + +++ +  +     L K       +   L EI   F E
Sbjct: 132 PNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDE 191

Query: 187 HQDGFWIYSEYCNNHLDACMELSKLMKDSRYQH 219
            +DGF    E   + +D    ++  + D + +H
Sbjct: 192 EEDGF----EVVEDAIDTMTCVAWYINDMKRRH 220


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score = 99.4 bits (246), Expect = 7e-21
 Identities = 87/343 (25%), Positives = 158/343 (46%), Gaps = 32/343 (9%)

Query: 101 DQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQM 160
           D  R   + EI  TE  Y + L+DI + Y+   R    + S   +  +F N+ED+ +   
Sbjct: 196 DDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL---VLSPADMAAVFINLEDLIKVHH 252

Query: 161 GFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSR-YQH 219
            F+R ++         L+++   FL+ ++   IY EYC++   A   L++L+     ++ 
Sbjct: 253 SFLRAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQ 309

Query: 220 FFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRN 279
             E C L  Q     +   L+ P+Q++ KY L L ELL ++A +  + + +  AL  M++
Sbjct: 310 KVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPERQQLKEALEAMQD 368

Query: 280 VTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRV 339
           +   INE KR  E + KI+++Q+S+ + + +  L+        GE+          Q R 
Sbjct: 369 LAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTKQDRY 426

Query: 340 FFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKET 399
            FLFD  +++CK+          KG    +  E++++   +  D  ++ K+  K H K  
Sbjct: 427 LFLFDKVVIVCKR----------KG-YSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMW 475

Query: 400 EE----IHL-------FFAKKLEEKIRWLRAFREERKMVQEDE 431
                 IHL       FF K  + K +W+  F      ++ D+
Sbjct: 476 SYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDK 518



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 18/55 (32%), Positives = 31/55 (56%), Gaps = 2/55 (3%)

Query: 10  IVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKD--WWWGQIDDEEGWFPASFV 62
           I +A A ++      REL+ + GDV+++      D  WW G+ +   GWFP+++V
Sbjct: 818 IGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 872


>gi|153791628 MCF.2 cell line derived transforming sequence isoform
           a [Homo sapiens]
          Length = 985

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 100/417 (23%), Positives = 179/417 (42%), Gaps = 74/417 (17%)

Query: 67  NQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDIC 126
           NQ +   E   D Q       S  L  G  L   D ++ +V+NE++ TER Y++ L  + 
Sbjct: 522 NQSNLKIEVVPDCQEKRSSGPSSSLDNGNSL---DVLKNHVLNELIQTERVYVRELYTVL 578

Query: 127 EGYLKQCRKRRDMFS------DEQLKVIFGNIEDIYRFQMG-FVRDLEKQYNNDDPHLSE 179
            GY  +     +MF         +  ++FGN+ +IY F    F+  LE   +  +     
Sbjct: 579 LGYRAEM-DNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPE----R 633

Query: 180 IGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEAC-RLLQQMIDIAIDGF 238
           +GPCFLE +D F +Y++YC N          + +      FF+ C R L+    + +D +
Sbjct: 634 VGPCFLERKDDFQMYAKYCQNK----PRSETIWRKYSECAFFQECQRKLKHR--LRLDSY 687

Query: 239 LLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIA 298
           LL PVQ+I KY L L ELLKY ++D      +  AL  M ++ + +N+           +
Sbjct: 688 LLKPVQRITKYQLLLKELLKY-SKDCEGSALLKKALDAMLDLLKSVND-----------S 735

Query: 299 QWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYG----------RNQQRVFFLFDHQMV 348
             Q ++  + G ++ +    ++  G   WI    G          +  QR  FL++  +V
Sbjct: 736 MHQIAINGYIG-NLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 794

Query: 349 LCKKDL------IRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEI 402
            CK+ +       R     +K    MD+  + +   G +          F++   E EE+
Sbjct: 795 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDN--------RKFEIWYGEKEEV 846

Query: 403 HLFFAKKLEEKIRWLRAF---------------REERKMVQEDEKIGFEISENQKRQ 444
           ++  A  ++ K+ WL+                 R+++  + E +K    + +N ++Q
Sbjct: 847 YIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQ 903


>gi|153791325 MCF.2 cell line derived transforming sequence isoform
           b [Homo sapiens]
          Length = 925

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 100/417 (23%), Positives = 179/417 (42%), Gaps = 74/417 (17%)

Query: 67  NQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDIC 126
           NQ +   E   D Q       S  L  G  L   D ++ +V+NE++ TER Y++ L  + 
Sbjct: 462 NQSNLKIEVVPDCQEKRSSGPSSSLDNGNSL---DVLKNHVLNELIQTERVYVRELYTVL 518

Query: 127 EGYLKQCRKRRDMFS------DEQLKVIFGNIEDIYRFQMG-FVRDLEKQYNNDDPHLSE 179
            GY  +     +MF         +  ++FGN+ +IY F    F+  LE   +  +     
Sbjct: 519 LGYRAEM-DNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPE----R 573

Query: 180 IGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEAC-RLLQQMIDIAIDGF 238
           +GPCFLE +D F +Y++YC N          + +      FF+ C R L+    + +D +
Sbjct: 574 VGPCFLERKDDFQMYAKYCQNK----PRSETIWRKYSECAFFQECQRKLKHR--LRLDSY 627

Query: 239 LLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIA 298
           LL PVQ+I KY L L ELLKY ++D      +  AL  M ++ + +N+           +
Sbjct: 628 LLKPVQRITKYQLLLKELLKY-SKDCEGSALLKKALDAMLDLLKSVND-----------S 675

Query: 299 QWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYG----------RNQQRVFFLFDHQMV 348
             Q ++  + G ++ +    ++  G   WI    G          +  QR  FL++  +V
Sbjct: 676 MHQIAINGYIG-NLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 734

Query: 349 LCKKDL------IRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEI 402
            CK+ +       R     +K    MD+  + +   G +          F++   E EE+
Sbjct: 735 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDN--------RKFEIWYGEKEEV 786

Query: 403 HLFFAKKLEEKIRWLRAF---------------REERKMVQEDEKIGFEISENQKRQ 444
           ++  A  ++ K+ WL+                 R+++  + E +K    + +N ++Q
Sbjct: 787 YIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQ 843


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 82/332 (24%), Positives = 157/332 (47%), Gaps = 15/332 (4%)

Query: 101 DQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQM 160
           D  R   + EI  TE  Y + L+DI + Y+   R    + S   +  +F N+ED+ +   
Sbjct: 191 DDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL---VLSPADMAAVFINLEDLIKVHH 247

Query: 161 GFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSR-YQH 219
            F+R ++         L+++   FL+ ++   IY EYC++   A   L++L+     ++ 
Sbjct: 248 SFLRAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQ 304

Query: 220 FFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRN 279
             E C L  Q     +   L+ P+Q++ KY L L ELL ++A +  + + +  AL  M++
Sbjct: 305 KVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPERQQLKEALEAMQD 363

Query: 280 VTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRV 339
           +   INE KR  E + KI+++Q+S+ + + +  L+        GE+          Q R 
Sbjct: 364 LAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTKQDRY 421

Query: 340 FFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKET 399
            FLFD  +++CK+     ++   K  I++  +++ D  D  ++         F L + + 
Sbjct: 422 LFLFDKVVIVCKRKGYSYEL---KEIIELLFHKMTD--DPMNNKDVKKWSYGFYLIHLQG 476

Query: 400 EEIHLFFAKKLEEKIRWLRAFREERKMVQEDE 431
           ++   FF K  + K +W+  F      ++ D+
Sbjct: 477 KQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDK 508



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 18/55 (32%), Positives = 31/55 (56%), Gaps = 2/55 (3%)

Query: 10  IVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKD--WWWGQIDDEEGWFPASFV 62
           I +A A ++      REL+ + GDV+++      D  WW G+ +   GWFP+++V
Sbjct: 779 IGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 833


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 80/326 (24%), Positives = 142/326 (43%), Gaps = 14/326 (4%)

Query: 96  PLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDI 155
           P       R   + EI  TE  Y   L  I + +LK  ++       + +++IF NIED+
Sbjct: 187 PKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQR---FLKPQDIEIIFINIEDL 243

Query: 156 YRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDS 215
            R    F++++++      P  + +   F+++++ F +Y  YC+    A   L ++    
Sbjct: 244 LRVHTHFLKEMKEALGT--PGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAR 301

Query: 216 R-YQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAAL 274
              Q   E C          +   L+ P+Q++ KY L L EL+K+T Q+  +   +  AL
Sbjct: 302 EDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT-QEAMEKENLRLAL 360

Query: 275 AVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGR 334
             MR++ Q +NE KR  E + +I  +Q S+ +   +  L         GE+         
Sbjct: 361 DAMRDLAQCVNEVKRDNETLRQITNFQLSIENL--DQSLAHYGRPKIDGELKITSVERRS 418

Query: 335 NQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKL 394
              R  FL D  +++CK+   R D    K  +++  ++V D  D   D  N    + F L
Sbjct: 419 KMDRYAFLLDKALLICKR---RGDSYDLKDFVNLHSFQVRD--DSSGDRDNKKWSHMFLL 473

Query: 395 HNKETEEIHLFFAKKLEEKIRWLRAF 420
              +  + +  F K  E K +W+  F
Sbjct: 474 IEDQGAQGYELFFKTRELKKKWMEQF 499



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 21/52 (40%), Positives = 32/52 (61%), Gaps = 1/52 (1%)

Query: 12  SAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWW-GQIDDEEGWFPASFV 62
           +A+A +D       EL+ K GD+IK+L+   +  WW G+I    GWFPA++V
Sbjct: 786 TAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYV 837



 Score = 30.0 bits (66), Expect = 5.3
 Identities = 14/44 (31%), Positives = 27/44 (61%), Gaps = 3/44 (6%)

Query: 27  LAFKAGDVIKVLDA-SNKDWWWGQ--IDDEEGWFPASFVRLWVN 67
           L    GD++++  A + ++WW G+    +E GWFP + V+ +V+
Sbjct: 617 LRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH 660


>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
           sapiens]
          Length = 776

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 83/366 (22%), Positives = 157/366 (42%), Gaps = 28/366 (7%)

Query: 26  ELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHLD 85
           EL+   GD+I V       WW G ++   GWFP+++VR   + E  +   P  V+     
Sbjct: 178 ELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPL--SPKAVKGFETA 235

Query: 86  PNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQL 145
           P +                  V+  I+ TE+ Y K L+ +   YL+  +   ++ S  ++
Sbjct: 236 PLT------------KNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNL-STVEV 282

Query: 146 KVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYCNNHLDA 204
             + GN E++  FQ    + LE + +    +  ++G C L     F  +Y  YC NH  A
Sbjct: 283 TSLLGNFEEVCTFQQTLCQALE-ECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSA 341

Query: 205 CMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDH 264
              L++       + F E        I + +   L  P  ++ KY   L EL ++    H
Sbjct: 342 VNVLTQ--HSDELEQFMENQGASSPGI-LILTTNLSKPFMRLEKYVTLLQELERHMEDTH 398

Query: 265 SDYRYVAAALAVMRNVTQQINE-RKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTG 323
            D++ +  A+   + +  Q  + RKR+   +  +++    +  WEGEDI +  + +I+  
Sbjct: 399 PDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSE---PIQAWEGEDIKNLGN-VIFMS 454

Query: 324 EMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIE--DGRD 381
           ++   Y      ++R   LF + +++      R     Y+G+I +    V  ++  +G D
Sbjct: 455 QVMVQYGACEEKEERYLMLFSNVLIMLSAS-PRMSGFIYQGKIPIAGTVVTRLDEIEGND 513

Query: 382 DDFNVS 387
             F ++
Sbjct: 514 CTFEIT 519


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 847

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 83/340 (24%), Positives = 155/340 (45%), Gaps = 20/340 (5%)

Query: 95  RPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIED 154
           +P    + +R+  + EI  TE  Y + L+ I E Y     KR    +  +   +F NI +
Sbjct: 184 QPKCPENDIRSCCLAEIKQTEEKYTETLESI-EKYFMAPLKR--FLTAAEFDSVFINIPE 240

Query: 155 IYRFQMGFVRDLEKQY-NNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMEL---SK 210
           + +     ++++     N +D +L ++   F+ +++   IY +YC+    A   L   SK
Sbjct: 241 LVKLHRNLMQEIHDSIVNKNDQNLYQV---FINYKERLVIYGQYCSGVESAISSLDYISK 297

Query: 211 LMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYV 270
             +D + +   E C          +   L+ P+Q++ KY L L EL+K+T  D ++   +
Sbjct: 298 TKEDVKLK--LEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTT-DPTEKANL 354

Query: 271 AAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQ 330
             AL  M+++ Q +NE KR  E + +I Q+Q S+ +     +L    +    GE+     
Sbjct: 355 KLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQ--GDGEIRITTL 412

Query: 331 PYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKN 390
                Q+R  FLFD  +++CK+   + D    K  ID+ +Y++ +  +   D  N     
Sbjct: 413 DKHTKQERHIFLFDLAVIVCKR---KGDNYEMKEIIDLQQYKIAN--NPTTDKENKKWSY 467

Query: 391 AFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQED 430
            F L + + +    F+ K  + K +WL  F      ++ D
Sbjct: 468 GFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPD 507



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 24/72 (33%), Positives = 40/72 (55%), Gaps = 12/72 (16%)

Query: 7   GDSIVS------AEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWW-GQIDDEEGWFPA 59
           G+S++S      A A +D      REL+   GDV+K+    + + WW G+++   GWFP+
Sbjct: 781 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS 840

Query: 60  SFVRLWVNQEDE 71
           ++V     +EDE
Sbjct: 841 TYV-----EEDE 847


>gi|163644325 MCF.2 cell line derived transforming sequence-like
           isoform a [Homo sapiens]
          Length = 1182

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 86/344 (25%), Positives = 151/344 (43%), Gaps = 56/344 (16%)

Query: 103 MRANVINEIMSTERHYIKHLKDICEGYLKQCRK--RRDMFSD---EQLKVIFGNIEDIYR 157
           +R +V++E++ TER Y++ L  + EGY  +        + S     +  V+FGN+E+IY 
Sbjct: 658 LRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYH 717

Query: 158 FQMG-FVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSR 216
           F    F+R+LE     D P L  +G CFLE  + F IY +YC N   +      L +   
Sbjct: 718 FHNRIFLRELENY--TDCPEL--VGRCFLERMEDFQIYEKYCQNKPRS----ESLWRQCS 769

Query: 217 YQHFFEACRLLQQMID--IAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAAL 274
              FF+ C   Q+ +D  +++D +LL PVQ+I KY L L E+LKY +++      +  AL
Sbjct: 770 DCPFFQEC---QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKY-SRNCEGAEDLQEAL 825

Query: 275 AVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGR 334
           + +  + + +N+    +           ++  ++G ++ D    L+      W     G 
Sbjct: 826 SSILGILKAVNDSMHLI-----------AITGYDG-NLGDLGKLLMQGSFSVWTDHKRGH 873

Query: 335 NQ----------QRVFFLFDHQMVLCKK------DLIRRDILYYKGRIDMDKYEVVDIED 378
            +          QR  FL +  ++ CKK         +     YK  ++M    + +   
Sbjct: 874 TKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVK 933

Query: 379 GRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFRE 422
           G            F++     EE+++  A   E K  W+   R+
Sbjct: 934 GD--------AKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRK 969


>gi|163644323 MCF.2 cell line derived transforming sequence-like
           isoform b [Homo sapiens]
          Length = 1129

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 86/344 (25%), Positives = 151/344 (43%), Gaps = 56/344 (16%)

Query: 103 MRANVINEIMSTERHYIKHLKDICEGYLKQCRK--RRDMFSD---EQLKVIFGNIEDIYR 157
           +R +V++E++ TER Y++ L  + EGY  +        + S     +  V+FGN+E+IY 
Sbjct: 605 LRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYH 664

Query: 158 FQMG-FVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSR 216
           F    F+R+LE     D P L  +G CFLE  + F IY +YC N   +      L +   
Sbjct: 665 FHNRIFLRELENY--TDCPEL--VGRCFLERMEDFQIYEKYCQNKPRS----ESLWRQCS 716

Query: 217 YQHFFEACRLLQQMID--IAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAAL 274
              FF+ C   Q+ +D  +++D +LL PVQ+I KY L L E+LKY +++      +  AL
Sbjct: 717 DCPFFQEC---QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKY-SRNCEGAEDLQEAL 772

Query: 275 AVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGR 334
           + +  + + +N+    +           ++  ++G ++ D    L+      W     G 
Sbjct: 773 SSILGILKAVNDSMHLI-----------AITGYDG-NLGDLGKLLMQGSFSVWTDHKRGH 820

Query: 335 NQ----------QRVFFLFDHQMVLCKK------DLIRRDILYYKGRIDMDKYEVVDIED 378
            +          QR  FL +  ++ CKK         +     YK  ++M    + +   
Sbjct: 821 TKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVK 880

Query: 379 GRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFRE 422
           G            F++     EE+++  A   E K  W+   R+
Sbjct: 881 GD--------AKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRK 916


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,808,719
Number of Sequences: 37866
Number of extensions: 907781
Number of successful extensions: 4083
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 219
Number of HSP's successfully gapped in prelim test: 138
Number of HSP's that attempted gapping in prelim test: 3484
Number of HSP's gapped (non-prelim): 554
length of query: 516
length of database: 18,247,518
effective HSP length: 107
effective length of query: 409
effective length of database: 14,195,856
effective search space: 5806105104
effective search space used: 5806105104
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.