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Search of human proteins with 7662102
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
(516 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 1063 0.0
gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo s... 487 e-138
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ... 437 e-122
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 425 e-119
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 424 e-118
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 138 1e-32
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 134 2e-31
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 133 3e-31
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 133 4e-31
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 128 1e-29
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 128 1e-29
gi|225579152 insulin-like growth factor binding protein, acid la... 124 2e-28
gi|4826772 insulin-like growth factor binding protein, acid labi... 124 2e-28
gi|153251229 chondroadherin precursor [Homo sapiens] 120 2e-27
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 119 5e-27
gi|198041768 synleurin [Homo sapiens] 117 3e-26
gi|194440719 chondroadherin-like [Homo sapiens] 116 4e-26
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo... 116 6e-26
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 115 7e-26
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 115 7e-26
gi|11321571 slit homolog 3 [Homo sapiens] 115 1e-25
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 113 4e-25
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 112 6e-25
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 112 6e-25
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 112 6e-25
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 112 8e-25
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 112 8e-25
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 112 8e-25
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 111 1e-24
gi|88702793 slit-like 2 [Homo sapiens] 107 2e-23
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 1063 bits (2750), Expect = 0.0
Identities = 516/516 (100%), Positives = 516/516 (100%)
Query: 1 MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATD 60
MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATD
Sbjct: 1 MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATD 60
Query: 61 KGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNK 120
KGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNK
Sbjct: 61 KGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNK 120
Query: 121 IFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDC 180
IFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDC
Sbjct: 121 IFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDC 180
Query: 181 RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNK 240
RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNK
Sbjct: 181 RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNK 240
Query: 241 ISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSL 300
ISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSL
Sbjct: 241 ISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSL 300
Query: 301 RSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLC 360
RSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLC
Sbjct: 301 RSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLC 360
Query: 361 WNLSTTVTVMATTYRDPTTEYTKRISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIFT 420
WNLSTTVTVMATTYRDPTTEYTKRISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIFT
Sbjct: 361 WNLSTTVTVMATTYRDPTTEYTKRISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIFT 420
Query: 421 QRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLRSQTRLHMSNMSD 480
QRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLRSQTRLHMSNMSD
Sbjct: 421 QRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLRSQTRLHMSNMSD 480
Query: 481 QGPYNEYEPTHEGPFIIINGYGQCKCQQLPYKECEV 516
QGPYNEYEPTHEGPFIIINGYGQCKCQQLPYKECEV
Sbjct: 481 QGPYNEYEPTHEGPFIIINGYGQCKCQQLPYKECEV 516
>gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
sapiens]
Length = 522
Score = 487 bits (1254), Expect = e-138
Identities = 248/525 (47%), Positives = 350/525 (66%), Gaps = 17/525 (3%)
Query: 1 MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATD 60
+GL W L P + + +MLPA CP CRCE L YC++ P+
Sbjct: 6 LGLCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEAPHNLS 65
Query: 61 KGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNK 120
G LGLSLR+N ++EL QF QLTWL+LDHN I +V+ DAFQ L ++KEL LSSN+
Sbjct: 66 -GLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQ 124
Query: 121 IFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDC 180
I LPNTTF + NL+++DLS+N+L +L P+LF+GLRKL TLH+R+N+++ +PVR+F DC
Sbjct: 125 ITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDC 184
Query: 181 RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNK 240
RSL+FLD+ N+L+SLARN FAGL KL ELHLEHN L K+NFAHF RL SLH+L L+ NK
Sbjct: 185 RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNK 244
Query: 241 ISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSL 300
++ + ++W W LEK+DL+GNEI+ ++ VFET+P+L+ L +D+N+L ++ +ILNS
Sbjct: 245 VAIVVSSLDWVW-NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSW 303
Query: 301 RSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLC 360
+SLT++ L+GNLW+C +CALASWL +FQGR++ ++ C SP++ QGED+LDAV+ F LC
Sbjct: 304 KSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLC 363
Query: 361 --------WNLSTTVTVMATTYRDPTTEYTKRISSSSYHVGDKEIPTTAGIAVTTEEHFP 412
+L + VT + ++ T H G E A +A+ EH
Sbjct: 364 EDGAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFE---PATVALPGGEH-- 418
Query: 413 EPDNAIFTQRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLRSQTR 472
+NA+ +V+TGTMAL+FSF ++ ++++S KC P +LR++RQC + Q +Q + QT
Sbjct: 419 -AENAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTM 477
Query: 473 LHMSNMSDQGPYNEYEPTH-EGPFIIINGYGQCKCQQLPYKECEV 516
M+ MS Q Y +Y+P H EG +IIN YG C C Q P +ECEV
Sbjct: 478 HQMAAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV 522
>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
sapiens]
Length = 581
Score = 437 bits (1123), Expect = e-122
Identities = 232/518 (44%), Positives = 334/518 (64%), Gaps = 7/518 (1%)
Query: 1 MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATD 60
MG + L +A + A +++L ML + CP CRCE + YC+SQ +P++
Sbjct: 1 MGFNVIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSIS 60
Query: 61 KGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNK 120
G LGLSLR+N + +L+ +QF +QLTWL+LDHN IS + E+AF G+ +LKELILSSN+
Sbjct: 61 AGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNR 120
Query: 121 IFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDC 180
I Y N TF + NL+NLDLS+NQL SL E F GLRKL +LHLRSNSLRTIPVR+F DC
Sbjct: 121 ISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDC 180
Query: 181 RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNK 240
R+LE LDL NR+RSLARN FAG+I+L+ELHLEHNQ +K+N A F RL SL L+LQWNK
Sbjct: 181 RNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNK 240
Query: 241 ISNLTCGMEWTWGTLEKLDLTGNEIKAID-LTVFETMPNLKILLMDNNKLNSLDSKILNS 299
IS + M WTW +L++LDL+GNEI+A +VF+ +PNL+ L +D+NKL + +IL+S
Sbjct: 241 ISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDS 300
Query: 300 LRSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQL 359
SL + L+GN+WECS IC+L +WL SF+G E++I+C SP QG +++DAV + +
Sbjct: 301 WISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSI 360
Query: 360 CWNLSTTVTVMATTYRDPTTEYTKRISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIF 419
C +T +A PT K H +P T G E + ++ F
Sbjct: 361 CGKSTTERFDLARALPKPT---FKPKLPRPKHESKPPLPPTVGATEPGPETDADAEHISF 417
Query: 420 TQRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLRSQTRLHMSNMS 479
++I G++AL S I+ ++++S K P ++++++Q S+++ HR+ + Q+ L S
Sbjct: 418 -HKIIAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQS-LKQMTPS 475
Query: 480 DQGPYNEYEPTH-EGPFIIINGYGQCKCQQLPYKECEV 516
Q Y +Y+PT+ E +++NG G C + +ECE+
Sbjct: 476 TQEFYVDYKPTNTETSEMLLNGTGPCTYNKSGSRECEI 513
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 425 bits (1093), Expect = e-119
Identities = 227/522 (43%), Positives = 329/522 (63%), Gaps = 10/522 (1%)
Query: 1 MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATD 60
MG H L + + +++L ML ACP CRC+ + YC+S F +P
Sbjct: 1 MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS 60
Query: 61 KGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNK 120
GS GLSLR N I +L+ +QFA +QL WL+LDHN IS+V EDAFQG+ +LKELILSSNK
Sbjct: 61 GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120
Query: 121 IFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDC 180
I YL N TF + NL+NLDLS+N+L +L E F GLRKL LHLRSNSL+T+P+R+F DC
Sbjct: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180
Query: 181 RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNK 240
R+L+FLDL NRLRSL+RN FAGL+KL+ELHLEHNQ +KINFAHF RL +L +++LQWN+
Sbjct: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240
Query: 241 ISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSL 300
I +++ G+ WTW +L LDL+GN+I+ I+ F+ +PNL+ L +D+NKL ++ + +N+
Sbjct: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW 300
Query: 301 RSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLC 360
SL ++ LSGN+WECS IC L WL +F+G E +++C P H QGE + DAV + +C
Sbjct: 301 ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360
Query: 361 WNLSTTVT----VMATTYRDPTTEYTKRISSSSYHVGDKEIPT-TAGIAVTTEEHFPEPD 415
+ T ++ T + P I E P+ + G + E E +
Sbjct: 361 SEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQ--EYE 418
Query: 416 NAIFTQRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLRSQTRLHM 475
+ F ++I G++AL S I+ ++++S K P ++++++Q S+++ R+ ++ M
Sbjct: 419 HVSF-HKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQM 477
Query: 476 SNMSDQGPYNEYEPTH-EGPFIIINGYGQCKCQQLPYKECEV 516
N Q Y +Y+PT+ E I +NG G C +ECEV
Sbjct: 478 -NSPLQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEV 518
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 424 bits (1090), Expect = e-118
Identities = 226/522 (43%), Positives = 329/522 (63%), Gaps = 10/522 (1%)
Query: 1 MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATD 60
MG H L + + +++L ML ACP CRC+ + YC+S F +P
Sbjct: 1 MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS 60
Query: 61 KGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNK 120
GS GLSLR N I +L+ +QFA +QL WL+LDHN IS+V EDAFQG+ +LKELILSSNK
Sbjct: 61 GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120
Query: 121 IFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDC 180
I YL N TF + NL+NLDLS+N+L +L E F GLRKL LHLRSNSL+T+P+R+F DC
Sbjct: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180
Query: 181 RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNK 240
R+L+FLDL NRLRSL+RN FAGL+KL+ELHLEHNQ +KINFAHF RL +L +++LQWN+
Sbjct: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240
Query: 241 ISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSL 300
I +++ G+ WTW +L LDL+GN+I+ I+ F+ +PNL+ L +D+NKL ++ + +N+
Sbjct: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW 300
Query: 301 RSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLC 360
SL ++ LSGN+WECS IC L WL +F+G E +++C P H QGE + DAV + +C
Sbjct: 301 ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360
Query: 361 WNLSTTVT----VMATTYRDPTTEYTKRISSSSYHVGDKEIPT-TAGIAVTTEEHFPEPD 415
+ T ++ T + P I E P+ + G + E E +
Sbjct: 361 SEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQ--EYE 418
Query: 416 NAIFTQRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLRSQTRLHM 475
+ F ++I G++AL S I+ ++++S K P ++++++Q S+++ R+ ++ M
Sbjct: 419 HVSF-HKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQM 477
Query: 476 SNMSDQGPYNEYEPTH-EGPFIIINGYGQCKCQQLPYKECEV 516
N Q Y +Y+PT+ E I +NG G C +ECE+
Sbjct: 478 -NSPLQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEM 518
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 138 bits (348), Expect = 1e-32
Identities = 94/295 (31%), Positives = 151/295 (51%), Gaps = 2/295 (0%)
Query: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
L L+ N + L R F + L L+L N ++ + E+ F L L+ L LS+N + LP
Sbjct: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP 209
Query: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEF 185
F +L +LQ L L N +S L P++F L L+ L L+ N++ +P+ +F +L F
Sbjct: 210 QGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTF 269
Query: 186 LDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLT 245
L L N LR L FA L L L HNQL + F LS+L +L L +N I++L
Sbjct: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329
Query: 246 CGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTT 305
G+ L KL L N + A+ +F+ + L++L + N+L +L I ++ +L
Sbjct: 330 AGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFN 389
Query: 306 VGLSGNLWECSARICALASWLGSFQGRWEH-SILCHSPDHTQGEDILDAVHGFQL 359
+ L GN W+C + L +WL + R + C P + +G+ ++ A++ QL
Sbjct: 390 LALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQ-VVPALNEKQL 443
Score = 107 bits (266), Expect = 3e-23
Identities = 91/323 (28%), Positives = 140/323 (43%), Gaps = 24/323 (7%)
Query: 13 MLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNH 72
ML + + L +L CP C C +C + +VP + +
Sbjct: 1 MLPGAWLLWTSLLLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETS 60
Query: 73 ITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKEL------------------ 114
T LE F S LT + + Q+ + DAF GL +L++L
Sbjct: 61 FTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNL 120
Query: 115 ------ILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNS 168
L+ N + LP F L L++L L NQL +L LF L L+TL+L N
Sbjct: 121 TSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL 180
Query: 169 LRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRL 228
L +P LF SL+ L LS N L L + F L L+EL L+ N ++++ F +L
Sbjct: 181 LAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQL 240
Query: 229 SSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNK 288
L L+LQ N I++L + + G L L L N ++ + +F P L L + +N+
Sbjct: 241 FCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQ 300
Query: 289 LNSLDSKILNSLRSLTTVGLSGN 311
L ++ L +L ++ LS N
Sbjct: 301 LETVAEGTFAHLSNLRSLMLSYN 323
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 134 bits (337), Expect = 2e-31
Identities = 101/332 (30%), Positives = 152/332 (45%), Gaps = 28/332 (8%)
Query: 8 PLGAPMLAAIYAMSMVLKMLPALGMA---CPPKCRCEKLL-FYCDSQGFHSVPNATDKGS 63
PL M Y + +V G+A CP +C C + C +VP +
Sbjct: 2 PLDKAMPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNA 61
Query: 64 LGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAF------------------ 105
+ L + + HITEL F + S L L ++ N++S + AF
Sbjct: 62 MSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQV 121
Query: 106 ------QGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKL 159
QGL L+ L+LSSN++ + F+Q NL+ L L N L + F L L
Sbjct: 122 LPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGL 181
Query: 160 QTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTK 219
L+L NSL I R+F +L+ L L NRL + F GL+ L+EL L+ NQ+
Sbjct: 182 TKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGL 241
Query: 220 INFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNL 279
++ F +L L+L N IS L + L +L L GN +K + L +F MPNL
Sbjct: 242 LSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNL 301
Query: 280 KILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
+ L + +N ++SL + ++LR L + LS N
Sbjct: 302 RELWLYDNHISSLPDNVFSNLRQLQVLILSRN 333
Score = 122 bits (305), Expect = 1e-27
Identities = 88/292 (30%), Positives = 138/292 (47%), Gaps = 2/292 (0%)
Query: 62 GSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKI 121
G L+L N +T + F L L L N+++ + F GL L+EL L N+I
Sbjct: 180 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 239
Query: 122 FYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCR 181
L F NLQ L LS N +S L P +F L +L L L NSL+ + + +F
Sbjct: 240 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 299
Query: 182 SLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKI 241
+L L L N + SL N F+ L +L+ L L NQ++ I+ F L+ L L L N +
Sbjct: 300 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 359
Query: 242 SNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLR 301
+L + L+ + L N ++ + +F + L + + NN+L +L I + L
Sbjct: 360 QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLG 419
Query: 302 SLTTVGLSGNLWECSARICALASWLGSFQGR--WEHSILCHSPDHTQGEDIL 351
L + L N W C + I L +WL Q R + +C SP + +G+ ++
Sbjct: 420 KLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLI 471
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 133 bits (335), Expect = 3e-31
Identities = 94/303 (31%), Positives = 142/303 (46%), Gaps = 25/303 (8%)
Query: 34 CPPKCRCEKLL-FYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHL 92
CP +C C + C +VP ++ L + + HITEL F + S L L +
Sbjct: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
Query: 93 DHNQISTVKEDAF------------------------QGLYKLKELILSSNKIFYLPNTT 128
+ N++S + AF QGL L+ L+LSSN++ +
Sbjct: 85 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
Query: 129 FTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDL 188
F+Q NL+ L L N L + F L L L+L NSL I R+F +L+ L L
Sbjct: 145 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 204
Query: 189 STNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGM 248
NRL + F GL+ L+EL L+ NQ+ ++ F +L L+L N IS L +
Sbjct: 205 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSI 264
Query: 249 EWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGL 308
L +L L GN +K + L +F MPNL+ L + +N ++SL + ++LR L + L
Sbjct: 265 FMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLIL 324
Query: 309 SGN 311
S N
Sbjct: 325 SRN 327
Score = 122 bits (305), Expect = 1e-27
Identities = 88/292 (30%), Positives = 138/292 (47%), Gaps = 2/292 (0%)
Query: 62 GSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKI 121
G L+L N +T + F L L L N+++ + F GL L+EL L N+I
Sbjct: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233
Query: 122 FYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCR 181
L F NLQ L LS N +S L P +F L +L L L NSL+ + + +F
Sbjct: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293
Query: 182 SLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKI 241
+L L L N + SL N F+ L +L+ L L NQ++ I+ F L+ L L L N +
Sbjct: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 353
Query: 242 SNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLR 301
+L + L+ + L N ++ + +F + L + + NN+L +L I + L
Sbjct: 354 QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLG 413
Query: 302 SLTTVGLSGNLWECSARICALASWLGSFQGR--WEHSILCHSPDHTQGEDIL 351
L + L N W C + I L +WL Q R + +C SP + +G+ ++
Sbjct: 414 KLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLI 465
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 133 bits (334), Expect = 4e-31
Identities = 121/416 (29%), Positives = 179/416 (43%), Gaps = 63/416 (15%)
Query: 24 LKMLPALGMACPPKCRCEKLL-FYCDSQGFHSVPNATDKGS----LGLSLRHNHITELER 78
L + P CP +C C+ C ++G VP + S L SL N IT +
Sbjct: 17 LALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITA 76
Query: 79 DQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNL 138
F QL L L +NQI ++ F+ L +L+EL L +N + L T L L+ L
Sbjct: 77 FDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRIL 136
Query: 139 DLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLAR 198
+ N++S L F GL L L L N+L +P +F +L +L L +NR+R L +
Sbjct: 137 YANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGK 196
Query: 199 NGFAGLIKLRELHL---------------------------------------EH----- 214
N FA L KLR L+L +H
Sbjct: 197 NAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLG 256
Query: 215 ------NQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAI 268
NQLT + F L +L L L+ N++S L + +LE LDL+GNE+ A+
Sbjct: 257 LLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSAL 316
Query: 269 DLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGS 328
F + L+ L + NN L++L I + +L + L GN W C R+ L W+G
Sbjct: 317 HPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGD 376
Query: 329 F--QGR-WEHSILCHSPDHTQGEDILDAVHGFQL----CWNLSTTVTVMATTYRDP 377
+ QGR + C P +G+ LD + QL C + S + ++ A R P
Sbjct: 377 WHSQGRLLTVFVQCRHPPALRGK-YLDYLDDQQLQNGSCADPSPSASLTADRRRQP 431
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 128 bits (322), Expect = 1e-29
Identities = 90/282 (31%), Positives = 135/282 (47%), Gaps = 5/282 (1%)
Query: 33 ACPPKCRCEK----LLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLT 88
ACP C C++ L C G +VP D + L L N++TEL+ F L
Sbjct: 34 ACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLE 93
Query: 89 WLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSL 148
L L N +S + AF GLY LK L+L +N++ +P +L +LQ+L L N +S +
Sbjct: 94 ELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLV 153
Query: 149 HPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLR 208
F GL L+ L L N+L IPVR + +L+ + L+ NR+ + F L L
Sbjct: 154 PERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLV 213
Query: 209 ELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAI 268
LHL +N++ + F L +L TL L +NK+ + T G L++L N IKAI
Sbjct: 214 VLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIR-TLGRLQELGFHNNNIKAI 272
Query: 269 DLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSG 310
F P L+ + +N + + L L T+ L+G
Sbjct: 273 PEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 314
Score = 85.1 bits (209), Expect = 1e-16
Identities = 77/270 (28%), Positives = 124/270 (45%), Gaps = 29/270 (10%)
Query: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
++L N I+ + F + + L LHL +N+I + +F+GL+ L+ L L+ NK+ P
Sbjct: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 250
Query: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTI------------- 172
T L LQ L N + ++ + F G LQT+H N ++ +
Sbjct: 251 VAIRT-LGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 309
Query: 173 -------PVRLFWDCR---SLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINF 222
++ F D + SLE L L+ +R L L +LR L L HNQ+ ++
Sbjct: 310 LSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS 369
Query: 223 AHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKIL 282
H R L + LQ N+I + +L+ LDL+ N I++I F T+ +L L
Sbjct: 370 LH--RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 427
Query: 283 LMDNNKLNSLDSKILNSLRSLTTVGLSGNL 312
+ +N+L +L L L L + L GNL
Sbjct: 428 DLTDNQLTTLP---LAGLGGLMHLKLKGNL 454
Score = 67.4 bits (163), Expect = 3e-11
Identities = 52/166 (31%), Positives = 75/166 (45%), Gaps = 4/166 (2%)
Query: 9 LGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSL 68
+G P+L I+ ++ + PK L D Q F + T L +L
Sbjct: 278 MGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEIL--TL 335
Query: 69 RHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTT 128
I L +L L L HNQI + + KL+E+ L N+I+ + T
Sbjct: 336 TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADT 393
Query: 129 FTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPV 174
F+QL +LQ LDLS+N + S+HPE F L L L L N L T+P+
Sbjct: 394 FSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPL 439
Score = 61.2 bits (147), Expect = 2e-09
Identities = 43/127 (33%), Positives = 62/127 (48%)
Query: 185 FLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNL 244
+LDLS N L L F L L EL L N L+ I F L SL L LQ N++ +
Sbjct: 70 YLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGI 129
Query: 245 TCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLT 304
W +L+ L L N I + FE + +L+ L +D+N L + + LN+L +L
Sbjct: 130 PAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQ 189
Query: 305 TVGLSGN 311
+ L+ N
Sbjct: 190 AMTLALN 196
Score = 43.9 bits (102), Expect = 4e-04
Identities = 27/79 (34%), Positives = 43/79 (54%)
Query: 234 LFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLD 293
L L N ++ L G+ LE+L L+GN + I F + +LKIL++ NN+L +
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 294 SKILNSLRSLTTVGLSGNL 312
++ L L SL ++ L NL
Sbjct: 131 AEALWELPSLQSLRLDANL 149
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 128 bits (321), Expect = 1e-29
Identities = 108/399 (27%), Positives = 172/399 (43%), Gaps = 63/399 (15%)
Query: 11 APMLAAIYAMSMVL--KMLPALGMACPPKCRC--EKLLFYCDSQGFHSVPNATDKGSLGL 66
+P+LA + +++ +L CPP+C C + C + F +VP + L
Sbjct: 17 SPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLL 76
Query: 67 SLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPN 126
L N I L +D+FASF L L L+ N +S V+ AF L+ L+ L L SN++ +P
Sbjct: 77 DLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPL 136
Query: 127 TTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFL 186
FT L NL LD+S N++ L +F L L++L + N L I R F SLE L
Sbjct: 137 GVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQL 196
Query: 187 DLSTNRLRSL---ARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSL------------ 231
L L S+ A + GLI LR HL N + +F RL L
Sbjct: 197 TLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMT 256
Query: 232 ----------------------------HTLFLQ-----WNKISNLTCGMEWTWGTLEKL 258
H ++L+ +N IS + M L+++
Sbjct: 257 PNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEI 316
Query: 259 DLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSAR 318
L G ++ ++ F + L++L + N+L +L+ + +S+ +L T+ L N C R
Sbjct: 317 QLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCR 376
Query: 319 ICALASWLGSFQGRWEHSI-----LCHSPDHTQGEDILD 352
+ L F+ RW + C +P+ QG++ D
Sbjct: 377 L------LWVFRRRWRLNFNRQQPTCATPEFVQGKEFKD 409
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 124 bits (311), Expect = 2e-28
Identities = 104/328 (31%), Positives = 154/328 (46%), Gaps = 16/328 (4%)
Query: 29 ALGMACPPKCRC------EKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFA 82
A G ACP C C ++L +C S+ +P+ G+ L L N+++ + F
Sbjct: 74 AEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQ 133
Query: 83 SFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSF 142
+ S L +L+L Q+ +++ A GL L L L N++ L TF L +L LS
Sbjct: 134 NLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSN 193
Query: 143 NQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFA 202
N+LS L LF GL L L+L NSL +P F SL L L+ NRL L F+
Sbjct: 194 NRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFS 253
Query: 203 GLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTG 262
GL +LREL L N L I F++L L L+L N I+ + G L LDL+
Sbjct: 254 GLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSH 313
Query: 263 NEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICAL 322
N + + F + L++L + +N + SL + L L + L N RI L
Sbjct: 314 NRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHN------RIRQL 367
Query: 323 ASWLGSFQGRWEHSILCHSPDHTQGEDI 350
A SF+G + +L + DH Q +++
Sbjct: 368 AE--RSFEGLGQLEVL--TLDHNQLQEV 391
Score = 120 bits (301), Expect = 3e-27
Identities = 84/249 (33%), Positives = 121/249 (48%)
Query: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
L L N I + F L WL L HN+++ + ED F GL L+ L LS N I L
Sbjct: 285 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR 344
Query: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEF 185
TF L L+ L L N++ L F GL +L+ L L N L+ + F ++
Sbjct: 345 PRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAV 404
Query: 186 LDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLT 245
++LS N LR+L F GL KL LHLE + L +I F LS L LFL+ N + +
Sbjct: 405 MNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE 464
Query: 246 CGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTT 305
W L +LDLT N++ + +F+ + L+ LL+ N+L L + L L+
Sbjct: 465 EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW 524
Query: 306 VGLSGNLWE 314
+ +S N E
Sbjct: 525 LDVSHNRLE 533
Score = 108 bits (270), Expect = 1e-23
Identities = 83/261 (31%), Positives = 130/261 (49%), Gaps = 5/261 (1%)
Query: 55 VPNATDKGSLG----LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYK 110
+P+A +G LG L L N + L+ F+ ++L L L N + +K + F L +
Sbjct: 223 LPDAAFRG-LGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPR 281
Query: 111 LKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLR 170
L++L L N I + F L L+ LDLS N+++ L + F GL L+ L L N++
Sbjct: 282 LQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIA 341
Query: 171 TIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSS 230
++ R F D LE L L NR+R LA F GL +L L L+HNQL ++ FL L++
Sbjct: 342 SLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN 401
Query: 231 LHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLN 290
+ + L N + NL + G L L L G+ + I F + L+ L + +N L
Sbjct: 402 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 461
Query: 291 SLDSKILNSLRSLTTVGLSGN 311
++ + L L L + L+ N
Sbjct: 462 GIEEQSLWGLAELLELDLTSN 482
Score = 107 bits (266), Expect = 3e-23
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 34/272 (12%)
Query: 63 SLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIF 122
SLGLS +N ++ LE F L L+L N ++ + + AF+GL L+EL+L+ N++
Sbjct: 188 SLGLS--NNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 245
Query: 123 YLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRS 182
YL F+ L L+ LDLS N L ++ +F L +LQ L+L N + + F ++
Sbjct: 246 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 305
Query: 183 LEFLDLSTNRLRSLARNGFAGLIKLR------------------------ELHLEHNQLT 218
L +LDLS NR+ L + F GL+ LR EL L HN++
Sbjct: 306 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 365
Query: 219 KINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPN 278
++ F L L L L N++ + G + ++L+GN ++ + VF +
Sbjct: 366 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 425
Query: 279 LKILLMDNNKLNSLDSKILNSLRSLTTVGLSG 310
L L L+ L +R T GLSG
Sbjct: 426 LHSL--------HLEGSCLGRIRPHTFTGLSG 449
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 124 bits (311), Expect = 2e-28
Identities = 104/328 (31%), Positives = 154/328 (46%), Gaps = 16/328 (4%)
Query: 29 ALGMACPPKCRC------EKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFA 82
A G ACP C C ++L +C S+ +P+ G+ L L N+++ + F
Sbjct: 36 AEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQ 95
Query: 83 SFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSF 142
+ S L +L+L Q+ +++ A GL L L L N++ L TF L +L LS
Sbjct: 96 NLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSN 155
Query: 143 NQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFA 202
N+LS L LF GL L L+L NSL +P F SL L L+ NRL L F+
Sbjct: 156 NRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFS 215
Query: 203 GLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTG 262
GL +LREL L N L I F++L L L+L N I+ + G L LDL+
Sbjct: 216 GLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSH 275
Query: 263 NEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICAL 322
N + + F + L++L + +N + SL + L L + L N RI L
Sbjct: 276 NRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHN------RIRQL 329
Query: 323 ASWLGSFQGRWEHSILCHSPDHTQGEDI 350
A SF+G + +L + DH Q +++
Sbjct: 330 AE--RSFEGLGQLEVL--TLDHNQLQEV 353
Score = 120 bits (301), Expect = 3e-27
Identities = 84/249 (33%), Positives = 121/249 (48%)
Query: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
L L N I + F L WL L HN+++ + ED F GL L+ L LS N I L
Sbjct: 247 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR 306
Query: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEF 185
TF L L+ L L N++ L F GL +L+ L L N L+ + F ++
Sbjct: 307 PRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAV 366
Query: 186 LDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLT 245
++LS N LR+L F GL KL LHLE + L +I F LS L LFL+ N + +
Sbjct: 367 MNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE 426
Query: 246 CGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTT 305
W L +LDLT N++ + +F+ + L+ LL+ N+L L + L L+
Sbjct: 427 EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW 486
Query: 306 VGLSGNLWE 314
+ +S N E
Sbjct: 487 LDVSHNRLE 495
Score = 108 bits (270), Expect = 1e-23
Identities = 83/261 (31%), Positives = 130/261 (49%), Gaps = 5/261 (1%)
Query: 55 VPNATDKGSLG----LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYK 110
+P+A +G LG L L N + L+ F+ ++L L L N + +K + F L +
Sbjct: 185 LPDAAFRG-LGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPR 243
Query: 111 LKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLR 170
L++L L N I + F L L+ LDLS N+++ L + F GL L+ L L N++
Sbjct: 244 LQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIA 303
Query: 171 TIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSS 230
++ R F D LE L L NR+R LA F GL +L L L+HNQL ++ FL L++
Sbjct: 304 SLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN 363
Query: 231 LHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLN 290
+ + L N + NL + G L L L G+ + I F + L+ L + +N L
Sbjct: 364 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 423
Query: 291 SLDSKILNSLRSLTTVGLSGN 311
++ + L L L + L+ N
Sbjct: 424 GIEEQSLWGLAELLELDLTSN 444
Score = 107 bits (266), Expect = 3e-23
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 34/272 (12%)
Query: 63 SLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIF 122
SLGLS +N ++ LE F L L+L N ++ + + AF+GL L+EL+L+ N++
Sbjct: 150 SLGLS--NNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 207
Query: 123 YLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRS 182
YL F+ L L+ LDLS N L ++ +F L +LQ L+L N + + F ++
Sbjct: 208 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 267
Query: 183 LEFLDLSTNRLRSLARNGFAGLIKLR------------------------ELHLEHNQLT 218
L +LDLS NR+ L + F GL+ LR EL L HN++
Sbjct: 268 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
Query: 219 KINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPN 278
++ F L L L L N++ + G + ++L+GN ++ + VF +
Sbjct: 328 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 387
Query: 279 LKILLMDNNKLNSLDSKILNSLRSLTTVGLSG 310
L L L+ L +R T GLSG
Sbjct: 388 LHSL--------HLEGSCLGRIRPHTFTGLSG 411
>gi|153251229 chondroadherin precursor [Homo sapiens]
Length = 359
Score = 120 bits (302), Expect = 2e-27
Identities = 105/377 (27%), Positives = 159/377 (42%), Gaps = 62/377 (16%)
Query: 12 PMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFY--CDSQGFHSVPNATDKGSL----- 64
PML + ++ ++ +LPAL ACP C C L + CD G +P ++K L
Sbjct: 4 PML--LLSLGLLAGLLPALA-ACPQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQR 60
Query: 65 ------------------GLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQ 106
L L+H I E+ F QL +L+L HN I ++ AF
Sbjct: 61 NNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFD 120
Query: 107 GLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRS 166
L +L L L NK+ LP + L+NL L L+ N++ L F G + L+ L+L
Sbjct: 121 DLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSE 180
Query: 167 NSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKI---NFA 223
N+L ++ D +L + N+L S + L + EL L HN L I F
Sbjct: 181 NALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQ 240
Query: 224 HFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILL 283
F R L TL+L + + G F + LK +
Sbjct: 241 SFGRY--LETLWLDNTNLEKFSDG------------------------AFLGVTTLKHVH 274
Query: 284 MDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPD 343
++NN+LN L S SL T+ L+ N W+C+ ++ L WL + R + + C SP
Sbjct: 275 LENNRLNQLPSNF--PFDSLETLALTNNPWKCTCQLRGLRRWLEAKASRPDAT--CASPA 330
Query: 344 HTQGEDILDAVHGFQLC 360
+G+ I D F+ C
Sbjct: 331 KFKGQHIRD-TDAFRSC 346
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 119 bits (299), Expect = 5e-27
Identities = 83/282 (29%), Positives = 132/282 (46%), Gaps = 6/282 (2%)
Query: 34 CPPKCRCEK-----LLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLT 88
CP C CE L C G +P+ + L L N+I++L + S L
Sbjct: 34 CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLE 93
Query: 89 WLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSL 148
L L N ++ + + AF GLY LK L+L +N++ ++P L +LQ+L L N +S +
Sbjct: 94 ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYV 153
Query: 149 HPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLR 208
P F GL L+ L L N+L IPV+ F +L+ + L+ N++ + F L L
Sbjct: 154 PPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213
Query: 209 ELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAI 268
LHL +N++ + F L SL TL L +N + + T L++L N I++I
Sbjct: 214 VLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIR-TLSNLKELGFHSNNIRSI 272
Query: 269 DLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSG 310
F P+L + +N + + L L T+ L+G
Sbjct: 273 PEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNG 314
Score = 87.0 bits (214), Expect = 4e-17
Identities = 78/293 (26%), Positives = 125/293 (42%), Gaps = 48/293 (16%)
Query: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
L L NHI+ + F+ L L LD N ++ + AF+ L L+ + L+ NKI ++P
Sbjct: 143 LRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIP 202
Query: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEF 185
+ F L +L L L N++ SL + F GL L+TL L N+L P + +L+
Sbjct: 203 DYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIR-TLSNLKE 261
Query: 186 LDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQW------- 238
L +N +RS+ F G L +H N + + + F L L TL L
Sbjct: 262 LGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEF 321
Query: 239 ---------------------------NKISNLTCGMEWTWGTLE------------KLD 259
N++ NL ++ ++ LE K+D
Sbjct: 322 PDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQV-LDLSYNLLEDLPSFSVCQKLQKID 380
Query: 260 LTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNL 312
L NEI I + F+ + +L+ L + NK+ + ++L SL + LS NL
Sbjct: 381 LRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNL 433
Score = 80.5 bits (197), Expect = 3e-15
Identities = 56/174 (32%), Positives = 86/174 (49%)
Query: 138 LDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLA 197
LDLS N +S L P LR L+ L L N+L IP F SL+ L L N+LR +
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
Query: 198 RNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEK 257
L L+ L L+ N ++ + + F L SL L+L N ++ + + L+
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
Query: 258 LDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
+ L N+I I F + +L +L + NN+++SL K + L SL T+ L+ N
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYN 244
Score = 80.5 bits (197), Expect = 3e-15
Identities = 69/229 (30%), Positives = 110/229 (48%), Gaps = 6/229 (2%)
Query: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
L L +N++ E + S L L N I ++ E AF G L + N I ++
Sbjct: 239 LDLNYNNLDEFPT-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVG 297
Query: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEF 185
+ F L L+ L L+ + P+L G L++L L + ++P + +L+
Sbjct: 298 RSAFQHLPELRTLTLNGASQITEFPDLT-GTANLESLTLTGAQISSLPQTVCNQLPNLQV 356
Query: 186 LDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLT 245
LDLS N L L F+ KL+++ L HN++ +I F +L SL +L L WNKI+ +
Sbjct: 357 LDLSYNLLEDLP--SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIH 414
Query: 246 CGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDS 294
T +L KLDL+ N + + +T + +LK L N+ L SL S
Sbjct: 415 PNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLK--LTGNHALQSLIS 461
Score = 53.5 bits (127), Expect = 4e-07
Identities = 36/120 (30%), Positives = 64/120 (53%), Gaps = 3/120 (2%)
Query: 56 PNATDKGSL-GLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKEL 114
P+ T +L L+L I+ L + L L L +N + + +F KL+++
Sbjct: 322 PDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP--SFSVCQKLQKI 379
Query: 115 ILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPV 174
L N+I+ + TF QL++L++L+L++N+++ +HP F L L L L SN L + P+
Sbjct: 380 DLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPI 439
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 117 bits (293), Expect = 3e-26
Identities = 86/283 (30%), Positives = 134/283 (47%), Gaps = 27/283 (9%)
Query: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
L L++N ++ + R F + +L+L N+++ + F G+ L+ L LS+N I +
Sbjct: 137 LYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRIS 196
Query: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEF 185
+ F L NL L L N L+ + F L+ L+ L L N + I F +LE+
Sbjct: 197 ESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEY 256
Query: 186 LDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLT 245
L L +R+R++ R+GF+G+ L+ L L HN L +N F L +L L
Sbjct: 257 LLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYL----------- 305
Query: 246 CGMEWTWGTLEKLDLTGNEIKAIDLTVFETM-PNLKILLMDNNKLNSLDSKILNSLRSLT 304
KLD N I +ID FE M +LKIL + N L +L ++L L SL
Sbjct: 306 -----------KLD--RNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLI 352
Query: 305 TVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQG 347
+ + N WEC+ ++ L WL S +I C +P +G
Sbjct: 353 HLQANSNPWECNCKLLGLRDWLAS--SAITLNIYCQNPPSMRG 393
Score = 112 bits (280), Expect = 8e-25
Identities = 70/223 (31%), Positives = 120/223 (53%)
Query: 89 WLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSL 148
+L+L N IS + E GL+ L L L ++ I Y+ F QL +L L L+ N + L
Sbjct: 64 FLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRL 123
Query: 149 HPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLR 208
P +F GL L+ L+L+ N + +P +F D S+++L+L NRL L F G++ LR
Sbjct: 124 DPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALR 183
Query: 209 ELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAI 268
L L +N + +I+ + F L +L L+L N ++ + +L +L L+ N I+AI
Sbjct: 184 ILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAI 243
Query: 269 DLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
F+ + NL+ LL+ N+++ ++ + + +L + LS N
Sbjct: 244 QPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHN 286
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 116 bits (291), Expect = 4e-26
Identities = 102/350 (29%), Positives = 151/350 (43%), Gaps = 7/350 (2%)
Query: 12 PMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFY--CDSQGFHSVPNATDKGSLGLSLR 69
P++ + + ++ A CP C C+ + C Q VP+A + + L L+
Sbjct: 11 PLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQ 70
Query: 70 HNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTF 129
N + + F LT L L H ++ V E AF+GL +L L L+SN + LP
Sbjct: 71 GNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEAL 130
Query: 130 TQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLS 189
L +L+ L+L N L L P F L L TL+L N+L +P F + +L LS
Sbjct: 131 DGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLS 190
Query: 190 TNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGME 249
N L LA AGL LR L L HN+L + + L L L N ++
Sbjct: 191 HNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDG 250
Query: 250 WTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLS 309
L +L L G ++A+ F P L L + N+L++L L L + L
Sbjct: 251 LALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQ 308
Query: 310 GNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQL 359
GN C + L WL + R + + C P +GE LDA+ + L
Sbjct: 309 GNPLWCGCQARPLLEWLARARVRSDGA--CQGPRRLRGE-ALDALRPWDL 355
Score = 88.6 bits (218), Expect = 1e-17
Identities = 88/355 (24%), Positives = 138/355 (38%), Gaps = 56/355 (15%)
Query: 34 CPPKCRC--EKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLH 91
CP C C E C+ G +VP + L LR NH + R F L LH
Sbjct: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455
Query: 92 LDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPE 151
L H I+ ++ A GL +L L LS N++ L L L L N+ +
Sbjct: 456 LQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGA 515
Query: 152 LFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELH 211
L L +LHL+ N++ + R+L ++ LS NR+ ++ +L +LH
Sbjct: 516 ALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLH 575
Query: 212 LEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLT 271
L+ NQL ++ T +E LE L L+GN ++A+
Sbjct: 576 LDRNQLREVP-----------------------TGALEGLPALLE-LQLSGNPLRALRDG 611
Query: 272 VFETM--------------------------PNLKILLMDNNKLNSLDSKILNSLRSLTT 305
F+ + P L+ L + N+L +L + L SL L
Sbjct: 612 AFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPA--LPSLSQLEL 669
Query: 306 VGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLC 360
+ LS N + C ++ L WL R C +P + +G+ + A F+ C
Sbjct: 670 IDLSSNPFHCDCQLLPLHRWLTGLNLR--VGATCATPPNARGQRVKAAAAVFEDC 722
>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
sapiens]
Length = 757
Score = 116 bits (290), Expect = 6e-26
Identities = 83/273 (30%), Positives = 136/273 (49%), Gaps = 2/273 (0%)
Query: 35 PPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDH 94
P +C C+ L CD +VP+ + + +SL+ N I +L D F ++ L L+L +
Sbjct: 101 PVQCLCQGLELDCDETNLRAVPSVSSNVT-AMSLQWNLIRKLPPDCFKNYHDLQKLYLQN 159
Query: 95 NQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFY 154
N+I+++ AF+GL L +L LS N+I +L F L L+ L + N LS + P FY
Sbjct: 160 NKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFY 219
Query: 155 GLRKLQTLHLRSNSLRTIPVR-LFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLE 213
GL L L L +N L +P + L L +LDL N + +L F L L +
Sbjct: 220 GLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMR 279
Query: 214 HNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVF 273
N++ +N F L L L L NKI NL + L +L+L+ N I+ I F
Sbjct: 280 KNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQF 339
Query: 274 ETMPNLKILLMDNNKLNSLDSKILNSLRSLTTV 306
+ + LK L ++ +++++ ++ L +L+ +
Sbjct: 340 DYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
Score = 75.5 bits (184), Expect = 1e-13
Identities = 57/179 (31%), Positives = 86/179 (48%), Gaps = 1/179 (0%)
Query: 134 NLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRL 193
N+ + L +N + L P+ F LQ L+L++N + +I + F SL L LS NR+
Sbjct: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
Query: 194 RSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCG-MEWTW 252
L F L +L L +E N L++I+ F L+SL L L N ++ L +
Sbjct: 187 TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHM 246
Query: 253 GTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
L LDL GN I + F + NL +L+M NK+N L+ L+ L + L N
Sbjct: 247 PRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN 305
Score = 62.0 bits (149), Expect = 1e-09
Identities = 43/152 (28%), Positives = 72/152 (47%), Gaps = 1/152 (0%)
Query: 66 LSLRHNHITEL-ERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYL 124
L L +N +T L ++ +L WL L+ N I ++ F L L++ NKI +L
Sbjct: 227 LVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHL 286
Query: 125 PNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLE 184
TF L L LDL N++ +L P +F L++L L+L N ++ I F L+
Sbjct: 287 NENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLK 346
Query: 185 FLDLSTNRLRSLARNGFAGLIKLRELHLEHNQ 216
L L + ++ + F L+ L ++ + Q
Sbjct: 347 SLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQ 378
Score = 36.2 bits (82), Expect = 0.074
Identities = 22/83 (26%), Positives = 39/83 (46%)
Query: 229 SSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNK 288
S++ + LQWN I L + L+KL L N+I +I + F + +L L + +N+
Sbjct: 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR 185
Query: 289 LNSLDSKILNSLRSLTTVGLSGN 311
+ L + L L + + N
Sbjct: 186 ITFLKPGVFEDLHRLEWLIIEDN 208
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 115 bits (289), Expect = 7e-26
Identities = 90/290 (31%), Positives = 135/290 (46%), Gaps = 4/290 (1%)
Query: 64 LGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFY 123
L L L N I+ + F QL L L+ N+I V FQGL LK L + N +
Sbjct: 195 LVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK 253
Query: 124 LPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSL 183
L + F L N++ L L N L+ + YGL LQ LHL N++ I + C+ L
Sbjct: 254 LMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKL 313
Query: 184 EFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISN 243
LDL+ N L L + F GL L LH+ +N+++ I F LSSL TL L+ N+IS
Sbjct: 314 SELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISW 373
Query: 244 LTCGMEWTWGTLEKLD---LTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSL 300
M + L+KL L GN I++I F + L+ L + +N + SL + +
Sbjct: 374 TIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQM 433
Query: 301 RSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDI 350
+ L + L+ + C ++ L W+ + + C P +G I
Sbjct: 434 KKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 483
Score = 91.3 bits (225), Expect = 2e-18
Identities = 81/304 (26%), Positives = 133/304 (43%), Gaps = 31/304 (10%)
Query: 34 CPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLD 93
CP CRC L C + +P L L HN ++ ++ + L + L+
Sbjct: 47 CPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLN 106
Query: 94 HNQISTVKE-----------------------DAFQGLYKLKELILSSNKIFYLPNTTFT 130
+N++ T+ + + L+ L LSSN I L T F
Sbjct: 107 NNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFP 165
Query: 131 QLINLQNLDLSFNQLSSLHPELFYGL-RKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLS 189
L L+ L L+ N+++S+ P F L L L L N + IP ++F L+ L+L+
Sbjct: 166 AL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELN 223
Query: 190 TNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGME 249
N+++++ F GL L+ L ++ N +TK+ F LS++ L L N ++ +T G
Sbjct: 224 RNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKG-- 281
Query: 250 WTWG--TLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVG 307
W +G L++L L+ N I I +E L L + N L+ LD L L T+
Sbjct: 282 WLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLH 341
Query: 308 LSGN 311
+ N
Sbjct: 342 IGNN 345
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 115 bits (289), Expect = 7e-26
Identities = 90/290 (31%), Positives = 135/290 (46%), Gaps = 4/290 (1%)
Query: 64 LGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFY 123
L L L N I+ + F QL L L+ N+I V FQGL LK L + N +
Sbjct: 135 LVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK 193
Query: 124 LPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSL 183
L + F L N++ L L N L+ + YGL LQ LHL N++ I + C+ L
Sbjct: 194 LMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKL 253
Query: 184 EFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISN 243
LDL+ N L L + F GL L LH+ +N+++ I F LSSL TL L+ N+IS
Sbjct: 254 SELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISW 313
Query: 244 LTCGMEWTWGTLEKLD---LTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSL 300
M + L+KL L GN I++I F + L+ L + +N + SL + +
Sbjct: 314 TIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQM 373
Query: 301 RSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDI 350
+ L + L+ + C ++ L W+ + + C P +G I
Sbjct: 374 KKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 423
Score = 81.3 bits (199), Expect = 2e-15
Identities = 70/230 (30%), Positives = 113/230 (49%), Gaps = 8/230 (3%)
Query: 85 SQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQ 144
+ +T L L N+I + + + L+ L LSSN I L T F L L+ L L+ N+
Sbjct: 61 ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNR 118
Query: 145 LSSLHPELFYGL-RKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAG 203
++S+ P F L L L L N + IP ++F L+ L+L+ N+++++ F G
Sbjct: 119 VTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQG 177
Query: 204 LIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWG--TLEKLDLT 261
L L+ L ++ N +TK+ F LS++ L L N ++ +T G W +G L++L L+
Sbjct: 178 LGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKG--WLYGLLMLQELHLS 235
Query: 262 GNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
N I I +E L L + N L+ LD L L T+ + N
Sbjct: 236 QNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNN 285
Score = 55.5 bits (132), Expect = 1e-07
Identities = 57/204 (27%), Positives = 92/204 (45%), Gaps = 27/204 (13%)
Query: 132 LINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIP------------------ 173
L ++ DLS N+LS + L+ L+ + L +N L TIP
Sbjct: 13 LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNR 72
Query: 174 -----VRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRL 228
+ +SLE LDLS+N + L + F L +L+ L+L N++T + +F L
Sbjct: 73 IVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNL 130
Query: 229 -SSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNN 287
++L L L N+IS + M + L+ L+L N+IK +D F+ + LK L M N
Sbjct: 131 ANTLLVLKLNRNRISAIPPKM-FKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRN 189
Query: 288 KLNSLDSKILNSLRSLTTVGLSGN 311
+ L L ++ + L N
Sbjct: 190 GVTKLMDGAFWGLSNMEILQLDHN 213
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 115 bits (287), Expect = 1e-25
Identities = 70/204 (34%), Positives = 100/204 (49%), Gaps = 2/204 (0%)
Query: 14 LAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHI 73
LA A++ VL PA+ ACP KC C C G +VP + + L L N+I
Sbjct: 16 LALALALASVLSGPPAV--ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNI 73
Query: 74 TELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLI 133
T + + FA L LHL+ NQ+S ++ AFQ L +L+ L L+ NK+ LP F
Sbjct: 74 TRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTP 133
Query: 134 NLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRL 193
L LDLS NQ+ + + F G+ ++ L L +N + I F R LE L L+ N +
Sbjct: 134 KLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNI 193
Query: 194 RSLARNGFAGLIKLRELHLEHNQL 217
+ F + K+R L L N L
Sbjct: 194 SRILVTSFNHMPKIRTLRLHSNHL 217
Score = 92.0 bits (227), Expect = 1e-18
Identities = 53/163 (32%), Positives = 81/163 (49%)
Query: 29 ALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLT 88
A ++CP C C + C +G +P +G + + L N I + F + +L
Sbjct: 275 ANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLK 334
Query: 89 WLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSL 148
+ + NQIS + DAFQGL L L+L NKI + F L++LQ L L+ N+++ L
Sbjct: 335 RIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCL 394
Query: 149 HPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTN 191
F L+ L L L N L+TI LF +S++ L L+ N
Sbjct: 395 RVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQN 437
Score = 79.3 bits (194), Expect = 8e-15
Identities = 53/187 (28%), Positives = 84/187 (44%), Gaps = 25/187 (13%)
Query: 30 LGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQ-FASFSQLT 88
+ + CP KCRCE + C +Q +P+ + L L N ++ LE F L
Sbjct: 501 MDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLR 560
Query: 89 WLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSL 148
++L +N+I V+E AF G ++EL+L+ N QL ++
Sbjct: 561 KINLSNNKIKEVREGAFDGAASVQELMLTGN------------------------QLETV 596
Query: 149 HPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLR 208
H +F GL L+TL LRSN + + F S+ L L NR+ ++ F L+ L
Sbjct: 597 HGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLS 656
Query: 209 ELHLEHN 215
++L N
Sbjct: 657 TINLLSN 663
Score = 75.9 bits (185), Expect = 8e-14
Identities = 58/227 (25%), Positives = 96/227 (42%), Gaps = 25/227 (11%)
Query: 134 NLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRL 193
N + LDL N ++ + F GL+ L+ LHL N + I F D + LE L L+ N+L
Sbjct: 62 NAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKL 121
Query: 194 RSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWG 253
+ L F KL L L NQ+ I F ++
Sbjct: 122 QVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITD----------------------- 158
Query: 254 TLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLW 313
++ L L N I I+ F + +L+IL ++NN ++ + N + + T+ L N
Sbjct: 159 -VKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 217
Query: 314 ECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLC 360
C + L+ WL + + + LC +P H +G ++ D +C
Sbjct: 218 YCDCHLAWLSDWLRQRRTVGQFT-LCMAPVHLRGFNVADVQKKEYVC 263
Score = 73.9 bits (180), Expect = 3e-13
Identities = 50/164 (30%), Positives = 72/164 (43%), Gaps = 25/164 (15%)
Query: 30 LGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTW 89
L CP +C C + + C ++G ++P K L L NH+T + R+ A
Sbjct: 721 LSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSA------- 773
Query: 90 LHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLH 149
L L + LS+N I L N TF+ + +L L LS+N+L +
Sbjct: 774 ------------------LRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIP 815
Query: 150 PELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRL 193
F GLR L+ L L N + ++P F D SL L L TN L
Sbjct: 816 VHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 859
Score = 73.6 bits (179), Expect = 4e-13
Identities = 49/138 (35%), Positives = 69/138 (50%), Gaps = 1/138 (0%)
Query: 113 ELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTI 172
E+ L N I +P FTQ L+ +D+S NQ+S + P+ F GL+ L +L L N + I
Sbjct: 311 EIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEI 370
Query: 173 PVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLH 232
LF SL+ L L+ N++ L N F L L L L N+L I+ F L S+
Sbjct: 371 AKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQ 430
Query: 233 TLFLQWNKISNLTCGMEW 250
TL L N C ++W
Sbjct: 431 TLHLAQNPFV-CDCHLKW 447
Score = 65.5 bits (158), Expect = 1e-10
Identities = 46/165 (27%), Positives = 77/165 (46%), Gaps = 24/165 (14%)
Query: 162 LHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKIN 221
+ L NS++ IP F + L+ +D+S N++ +A + F GL L L L N++T+I
Sbjct: 312 IRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIA 371
Query: 222 FAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKI 281
F L SL L L NKI+ L + F+ + NL +
Sbjct: 372 KGLFDGLVSLQLLLLNANKINCLR------------------------VNTFQDLQNLNL 407
Query: 282 LLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWL 326
L + +NKL ++ + L+S+ T+ L+ N + C + LA +L
Sbjct: 408 LSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYL 452
Score = 56.6 bits (135), Expect = 5e-08
Identities = 70/324 (21%), Positives = 128/324 (39%), Gaps = 58/324 (17%)
Query: 61 KGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNK 120
K L L N ITE+ + F L L L+ N+I+ ++ + FQ L L L L NK
Sbjct: 355 KSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNK 414
Query: 121 IFYLPNTTFTQLINLQNLDLSFNQ-LSSLHPELFYGLRK---LQTLHLRSNSLRTIPVRL 176
+ + F L ++Q L L+ N + H + + ++T R +S R + +
Sbjct: 415 LQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKR 474
Query: 177 FWDCRSLEFLDLSTNRLRS-LARNGFAGLI----------------------------KL 207
+S +F + RS + F L+ +
Sbjct: 475 ISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYV 534
Query: 208 RELHLEHNQLTKINFAH-FLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIK 266
+L L N+++ + F +L +L + L NKI + G ++++L LTGN+++
Sbjct: 535 TDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLE 594
Query: 267 AIDLTVFETMPNLKILLMD------------------------NNKLNSLDSKILNSLRS 302
+ VF + LK L++ +N++ ++ +L S
Sbjct: 595 TVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVS 654
Query: 303 LTTVGLSGNLWECSARICALASWL 326
L+T+ L N + C+ + L WL
Sbjct: 655 LSTINLLSNPFNCNCHLAWLGKWL 678
Score = 47.8 bits (112), Expect = 2e-05
Identities = 38/117 (32%), Positives = 57/117 (48%), Gaps = 2/117 (1%)
Query: 134 NLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRL 193
++ L L N L+++ EL LR L + L +NS+ + F + L L LS NRL
Sbjct: 753 DVTELYLEGNHLTAVPRELS-ALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRL 811
Query: 194 RSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEW 250
R + + F GL LR L L N ++ + F L+SL L L N + + C + W
Sbjct: 812 RCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL-HCDCSLRW 867
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 113 bits (283), Expect = 4e-25
Identities = 104/351 (29%), Positives = 165/351 (47%), Gaps = 46/351 (13%)
Query: 1 MGLHFKWPL--------GAPMLAAIY--AMSMVLKMLPALGMACPPKCRCEKL-LFYCDS 49
MG +WP G P +A + A + + L L ACP +C C ++ CD
Sbjct: 1 MGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDG 60
Query: 50 QGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQIST--VKEDAFQG 107
P+ + + LSL++N + EL ++ + S L L+L +N IS+ + ++AF+
Sbjct: 61 LDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFES 120
Query: 108 LYKLKELILSSNKIFYLPN---------------------TTFTQLINLQNLDLSFNQLS 146
L +L+ L ++ NK+ P TF + L+++ L NQLS
Sbjct: 121 LTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLS 180
Query: 147 S--LHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGL 204
+ L P+ F G + TL L +N L +P L SLE L L N + + R +
Sbjct: 181 NAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLERLHLQNNLISKVPRGALSRQ 237
Query: 205 IKLRELHLEHNQLTK--INFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTG 262
+LREL+L+HNQLT ++ F +L SL L L N+++ + G+ TL L L
Sbjct: 238 TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLP---RTLAILHLGR 294
Query: 263 NEIKAIDLTVFETMPNLKILLMDNNKLNS--LDSKILNSLRSLTTVGLSGN 311
N I+ ++ L+ LL+ +N+L S L + L LR L T+ L GN
Sbjct: 295 NRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGN 345
Score = 68.9 bits (167), Expect = 1e-11
Identities = 76/273 (27%), Positives = 118/273 (43%), Gaps = 36/273 (13%)
Query: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFY-- 123
LSL +N ++ L S +L HL +N IS V A +L+EL L N++
Sbjct: 198 LSLSNNQLSYLPPSLPPSLERL---HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSG 254
Query: 124 LPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSL 183
L TTF++L +L+ LDLS NQL+++ L R L LHL N +R + R L
Sbjct: 255 LDATTFSKLHSLEYLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGL 311
Query: 184 EFLDLSTNRLRS------------------LARNGFAGLI-----KLRELHLEHNQLTKI 220
+L L N+L S L NG + +LR L L HN + +
Sbjct: 312 RYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAAL 371
Query: 221 NFAHFLRLSSLHTLFLQWNKISNLTCGME--WTWGTLEKLDLTGNEIKAIDLTVFETMPN 278
+ L L L +N++++ L LDL GN++ + + +
Sbjct: 372 GARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGL---PTG 428
Query: 279 LKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
L+ L + N+L L+ + L L L + L+ N
Sbjct: 429 LRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHN 461
Score = 61.6 bits (148), Expect = 2e-09
Identities = 56/189 (29%), Positives = 85/189 (44%), Gaps = 28/189 (14%)
Query: 54 SVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDA-----FQGL 108
+VP + L L N I ++E + L +L L HNQ+ + A +GL
Sbjct: 278 TVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGL 337
Query: 109 Y------------------KLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSS--L 148
+ +L+ L+L N + L L L+L++N+L+S +
Sbjct: 338 HTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARV 397
Query: 149 HPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLR 208
H F LR L++L L N L +P+ L R+L+ L N+LR L AGL +LR
Sbjct: 398 HHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ---LQRNQLRMLEPEPLAGLDQLR 454
Query: 209 ELHLEHNQL 217
EL L HN+L
Sbjct: 455 ELSLAHNRL 463
Score = 56.2 bits (134), Expect = 7e-08
Identities = 43/122 (35%), Positives = 60/122 (49%), Gaps = 5/122 (4%)
Query: 51 GFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQIST--VKEDAFQGL 108
G VP A + L L HNH+ L + LT L+L +N++++ V AF+ L
Sbjct: 346 GLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRL 405
Query: 109 YKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNS 168
L+ L L+ N++ LP T L+ L L NQL L PE GL +L+ L L N
Sbjct: 406 RALRSLDLAGNQLTRLPMGLPT---GLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNR 462
Query: 169 LR 170
LR
Sbjct: 463 LR 464
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 112 bits (281), Expect = 6e-25
Identities = 79/278 (28%), Positives = 136/278 (48%), Gaps = 2/278 (0%)
Query: 34 CPPKCRCE-KLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHL 92
C C C+ C +G +VP + L + N+IT+L D F +F L L L
Sbjct: 29 CAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQL 88
Query: 93 DHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPEL 152
N +S + A GL +LK L L +N++ +P+ L LQ+L L N ++S+ +
Sbjct: 89 AGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDS 148
Query: 153 FYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHL 212
F GL +L+ L L NSL +PV + +L+ L L+ N++ S+ F L L LHL
Sbjct: 149 FEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHL 208
Query: 213 EHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTV 272
+N++ ++ F L +L TL L +N + ++ +L++L N I I
Sbjct: 209 HNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIK-ALPSLKELGFHSNSISVIPDGA 267
Query: 273 FETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSG 310
F+ P L+ + + +N L+ + + ++L L ++ + G
Sbjct: 268 FDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRG 305
Score = 95.1 bits (235), Expect = 1e-19
Identities = 70/212 (33%), Positives = 105/212 (49%), Gaps = 25/212 (11%)
Query: 114 LILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIP 173
L +S N I LP F L+ L L+ N LS +HP+ GL++L+ L L++N L+T+P
Sbjct: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121
Query: 174 VRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHT 233
+L+ L L N + S+ + F GL++LR L L+ N LT++ +H
Sbjct: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEV---------PVHP 172
Query: 234 LFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLD 293
L SNL TL+ L L N+I +I F + +L +L + NNK+ SL
Sbjct: 173 L-------SNLP--------TLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLS 217
Query: 294 SKILNSLRSLTTVGLS-GNLWECSARICALAS 324
+ L +L T+ L+ NL E I AL S
Sbjct: 218 QHCFDGLDNLETLDLNYNNLGEFPQAIKALPS 249
Score = 76.6 bits (187), Expect = 5e-14
Identities = 71/240 (29%), Positives = 111/240 (46%), Gaps = 7/240 (2%)
Query: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
L L +N++ E + + L L N IS + + AF G L+ + L N + ++
Sbjct: 230 LDLNYNNLGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVG 288
Query: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEF 185
N+ F L +L +L + + P L G L++L L + +IP L + + L
Sbjct: 289 NSAFHNLSDLHSLVIRGASMVQQFPNLT-GTVHLESLTLTGTKISSIPNNLCQEQKMLRT 347
Query: 186 LDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLT 245
LDLS N +R L F G L E+ L+ NQ+ +I F L SL L L N I +
Sbjct: 348 LDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIH 405
Query: 246 CGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKL-NSLDSKILNSLRSLT 304
T G + LD++ NE+ + + LK L+ N KL +L +K +LRSL+
Sbjct: 406 SRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK--LVGNFKLKEALAAKDFVNLRSLS 463
Score = 58.5 bits (140), Expect = 1e-08
Identities = 48/145 (33%), Positives = 67/145 (46%), Gaps = 18/145 (12%)
Query: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
L L +N+I +L F L + L NQI +KE FQGL L+ L LS N I +
Sbjct: 348 LDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIH 405
Query: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQT---------------LHLRSNSL- 169
+ F L + NLD+SFN+L+S E GL +L+ ++LRS S+
Sbjct: 406 SRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVP 465
Query: 170 RTIPVRLFWDCRSLEFLDLSTNRLR 194
FW C S L+ N L+
Sbjct: 466 YAYQCCAFWGCDSYANLNTEDNSLQ 490
Score = 55.8 bits (133), Expect = 9e-08
Identities = 52/175 (29%), Positives = 77/175 (44%), Gaps = 9/175 (5%)
Query: 51 GFHS-----VPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLH-LDHNQISTVKE-D 103
GFHS +P+ G+ L H + L ++F L+ LH L S V++
Sbjct: 254 GFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFP 313
Query: 104 AFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLH 163
G L+ L L+ KI +PN + L+ LDLS+N + L F G L+ +
Sbjct: 314 NLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEIS 371
Query: 164 LRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLT 218
L+ N + I F SL LDLS N + + FA L + L + N+LT
Sbjct: 372 LQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELT 426
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 112 bits (281), Expect = 6e-25
Identities = 104/374 (27%), Positives = 155/374 (41%), Gaps = 63/374 (16%)
Query: 9 LGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFY-------------CDSQGFHSV 55
L AP+L A A + + + CPP+C C+ +Y C+ +V
Sbjct: 4 LVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAV 63
Query: 56 PNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELI 115
P A G+ L L+ N I +++ + + LT L L N S ++ F L +L L
Sbjct: 64 PPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLH 123
Query: 116 LSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVR 175
L N++ L + +F L +LQ L L+ NQL + P F GL L LHL SN LR I R
Sbjct: 124 LEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSR 183
Query: 176 LFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTL- 234
F +LE L + N++ ++ F L LR L L L +I+ L SL +L
Sbjct: 184 WFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLS 243
Query: 235 ---------------------FLQWNK----------ISNLTCGMEWTWGTLE------- 256
FL NK +N+ E +E
Sbjct: 244 FYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDK 303
Query: 257 ----------KLDLTGN-EIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTT 305
KLD+T N + I F +P ++ L+++NN L++L + + SL +L
Sbjct: 304 FALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE 363
Query: 306 VGLSGNLWECSARI 319
VGL GN C I
Sbjct: 364 VGLHGNPIRCDCVI 377
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 112 bits (281), Expect = 6e-25
Identities = 104/374 (27%), Positives = 155/374 (41%), Gaps = 63/374 (16%)
Query: 9 LGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFY-------------CDSQGFHSV 55
L AP+L A A + + + CPP+C C+ +Y C+ +V
Sbjct: 4 LVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAV 63
Query: 56 PNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELI 115
P A G+ L L+ N I +++ + + LT L L N S ++ F L +L L
Sbjct: 64 PPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLH 123
Query: 116 LSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVR 175
L N++ L + +F L +LQ L L+ NQL + P F GL L LHL SN LR I R
Sbjct: 124 LEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSR 183
Query: 176 LFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTL- 234
F +LE L + N++ ++ F L LR L L L +I+ L SL +L
Sbjct: 184 WFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLS 243
Query: 235 ---------------------FLQWNK----------ISNLTCGMEWTWGTLE------- 256
FL NK +N+ E +E
Sbjct: 244 FYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDK 303
Query: 257 ----------KLDLTGN-EIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTT 305
KLD+T N + I F +P ++ L+++NN L++L + + SL +L
Sbjct: 304 FALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE 363
Query: 306 VGLSGNLWECSARI 319
VGL GN C I
Sbjct: 364 VGLHGNPIRCDCVI 377
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 112 bits (280), Expect = 8e-25
Identities = 96/315 (30%), Positives = 152/315 (48%), Gaps = 36/315 (11%)
Query: 27 LPALGMACPPKCRCEKL-LFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFS 85
L L ACP +C C ++ CD P+ + + LSL++N + EL ++ + S
Sbjct: 39 LQPLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLS 98
Query: 86 QLTWLHLDHNQIST--VKEDAFQGLYKLKELILSSNKIFYLPN----------------- 126
L L+L +N IS+ + ++AF+ L +L+ L ++ NK+ P
Sbjct: 99 GLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVM 158
Query: 127 ----TTFTQLINLQNLDLSFNQLSS--LHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDC 180
TF + L+++ L NQLS+ L P+ F G + TL L +N L +P L
Sbjct: 159 EIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---P 215
Query: 181 RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTK--INFAHFLRLSSLHTLFLQW 238
SLE L L N + + R + +LREL+L+HNQLT ++ F +L SL L L
Sbjct: 216 PSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSH 275
Query: 239 NKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNS--LDSKI 296
N+++ + G+ TL L L N I+ ++ L+ LL+ +N+L S L +
Sbjct: 276 NQLTTVPAGLP---RTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGA 332
Query: 297 LNSLRSLTTVGLSGN 311
L LR L T+ L GN
Sbjct: 333 LRPLRGLHTLHLYGN 347
Score = 68.9 bits (167), Expect = 1e-11
Identities = 76/273 (27%), Positives = 118/273 (43%), Gaps = 36/273 (13%)
Query: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFY-- 123
LSL +N ++ L S +L HL +N IS V A +L+EL L N++
Sbjct: 200 LSLSNNQLSYLPPSLPPSLERL---HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSG 256
Query: 124 LPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSL 183
L TTF++L +L+ LDLS NQL+++ L R L LHL N +R + R L
Sbjct: 257 LDATTFSKLHSLEYLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGL 313
Query: 184 EFLDLSTNRLRS------------------LARNGFAGLI-----KLRELHLEHNQLTKI 220
+L L N+L S L NG + +LR L L HN + +
Sbjct: 314 RYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAAL 373
Query: 221 NFAHFLRLSSLHTLFLQWNKISNLTCGME--WTWGTLEKLDLTGNEIKAIDLTVFETMPN 278
+ L L L +N++++ L LDL GN++ + + +
Sbjct: 374 GARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGL---PTG 430
Query: 279 LKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
L+ L + N+L L+ + L L L + L+ N
Sbjct: 431 LRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHN 463
Score = 61.6 bits (148), Expect = 2e-09
Identities = 56/189 (29%), Positives = 85/189 (44%), Gaps = 28/189 (14%)
Query: 54 SVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDA-----FQGL 108
+VP + L L N I ++E + L +L L HNQ+ + A +GL
Sbjct: 280 TVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGL 339
Query: 109 Y------------------KLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSS--L 148
+ +L+ L+L N + L L L+L++N+L+S +
Sbjct: 340 HTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARV 399
Query: 149 HPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLR 208
H F LR L++L L N L +P+ L R+L+ L N+LR L AGL +LR
Sbjct: 400 HHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ---LQRNQLRMLEPEPLAGLDQLR 456
Query: 209 ELHLEHNQL 217
EL L HN+L
Sbjct: 457 ELSLAHNRL 465
Score = 56.2 bits (134), Expect = 7e-08
Identities = 43/122 (35%), Positives = 60/122 (49%), Gaps = 5/122 (4%)
Query: 51 GFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQIST--VKEDAFQGL 108
G VP A + L L HNH+ L + LT L+L +N++++ V AF+ L
Sbjct: 348 GLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRL 407
Query: 109 YKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNS 168
L+ L L+ N++ LP T L+ L L NQL L PE GL +L+ L L N
Sbjct: 408 RALRSLDLAGNQLTRLPMGLPT---GLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNR 464
Query: 169 LR 170
LR
Sbjct: 465 LR 466
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 112 bits (280), Expect = 8e-25
Identities = 92/331 (27%), Positives = 147/331 (44%), Gaps = 28/331 (8%)
Query: 8 PLGAPMLAAIYAMSMVLKMLPALG---MACPPKCRCEKLLFYCDSQGFHSVPNATDKGSL 64
P +P L ++ + + L+ + A C C C C +G ++P +
Sbjct: 12 PRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTR 71
Query: 65 GLSLRHNHITELERDQF-----------------------ASFSQLTWLHLDHNQISTVK 101
L+L +N ++E++ F A+ S + L L HN+I +V+
Sbjct: 72 SLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVE 131
Query: 102 EDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGL-RKLQ 160
+ L+ L LS N I + NT F ++ L+L+ N++ +L F GL R L
Sbjct: 132 GSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLL 191
Query: 161 TLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKI 220
TL L N + +PVR F L LDL+ NR+R + F GL L L L+ N ++K+
Sbjct: 192 TLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKL 250
Query: 221 NFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLK 280
F LS +H L L++N + + G + L +L L+ N I I + L
Sbjct: 251 TDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLH 310
Query: 281 ILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
L++ N L LD + L L SL+ + LS N
Sbjct: 311 ELVLSFNNLTRLDEESLAELSSLSVLRLSHN 341
Score = 105 bits (261), Expect = 1e-22
Identities = 91/313 (29%), Positives = 143/313 (45%), Gaps = 29/313 (9%)
Query: 66 LSLRHNHITELERDQFASFSQ-LTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYL 124
L+L N I LE F S+ L L L N+I+ + AF+ L +L +L L+ N+I +
Sbjct: 168 LNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLI 226
Query: 125 PNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLE 184
TF L +L+ L L N +S L F+GL K+ LHL NSL + + +L
Sbjct: 227 EGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALH 286
Query: 185 FLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNL 244
L LS N + + R G++ KL EL L N LT+++ LSSL L L N IS++
Sbjct: 287 QLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHI 346
Query: 245 TCG---------------------MEWTWG------TLEKLDLTGNEIKAIDLTVFETMP 277
G +E T G +L KL L GN+IK++ F +
Sbjct: 347 AEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLE 406
Query: 278 NLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSI 337
L+ L + N + S+ +++L + +S + + C ++ L WL + +
Sbjct: 407 GLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTA 466
Query: 338 LCHSPDHTQGEDI 350
C P+ +G+ I
Sbjct: 467 TCAHPESLKGQSI 479
Score = 90.1 bits (222), Expect = 4e-18
Identities = 81/249 (32%), Positives = 106/249 (42%), Gaps = 34/249 (13%)
Query: 64 LGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFY 123
L L L N IT+L F +LT L L+ N+I ++ FQGL L+ L L N I
Sbjct: 191 LTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISK 249
Query: 124 LPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSL 183
L + F L + L L +N L ++ YGL L LHL +NS+ I + + C+ L
Sbjct: 250 LTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKL 309
Query: 184 EFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISN 243
L LS N L L A L L L L HN ++ I F L SL L L N+IS
Sbjct: 310 HELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISG 369
Query: 244 LTCGMEWTWGT------------------------------LEKLDLTGNEIKAIDLTVF 273
+E T G LE L+L GN I+++ F
Sbjct: 370 T---IEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAF 426
Query: 274 ETMPNLKIL 282
M NLK L
Sbjct: 427 VKMKNLKEL 435
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 112 bits (280), Expect = 8e-25
Identities = 97/314 (30%), Positives = 147/314 (46%), Gaps = 28/314 (8%)
Query: 66 LSLRHNHITELERDQFASFSQ------------------------LTWLHLDHNQISTVK 101
L+L +N IT LE F + S L +L L N+I V+
Sbjct: 172 LNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVE 231
Query: 102 EDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQT 161
FQGL L+ L + N I L + F L N++ L+L N L+ ++ YGLR LQ
Sbjct: 232 GLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQ 291
Query: 162 LHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKIN 221
L++ N++ I + C+ L LDLS N+L L + F GL L L+L N++T I
Sbjct: 292 LYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIA 351
Query: 222 FAHFLRLSSLHTLFLQWNKIS-NLTCGMEWTWG--TLEKLDLTGNEIKAIDLTVFETMPN 278
F LS+L TL L+ N+IS + E G +L KL L GN+IK+I F + +
Sbjct: 352 DGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLES 411
Query: 279 LKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSIL 338
L+ L ++NN + S+ S L + L+ + C + L WL + ++
Sbjct: 412 LEHLDLNNNAIMSIQENAF-SQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVS 470
Query: 339 CHSPDHTQGEDILD 352
C P+ G+ IL+
Sbjct: 471 CAHPEWLAGQSILN 484
Score = 89.4 bits (220), Expect = 7e-18
Identities = 88/347 (25%), Positives = 145/347 (41%), Gaps = 54/347 (15%)
Query: 17 IYAMSMVLKMLPALGMA-CPPKCRCEKLLFYCDSQ-----GFHSVPNATDKGSLGLSLRH 70
++ L +LPA G CP C C L C + + ++ + L H
Sbjct: 25 LFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSH 84
Query: 71 NHITEL-----------------ERDQFASF----SQLTWLHLDHNQISTVKEDAFQGLY 109
N ++ E + F S +T L L HN I + A Q
Sbjct: 85 NRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYP 144
Query: 110 KLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGL-RKLQTLHLRSNS 168
L+ L LSSN I + ++F ++ L+ L+LS N++++L F L L + L N
Sbjct: 145 ALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNR 203
Query: 169 LRTIPVRLFWDCRSLEFLDLSTNRLR----------------SLARNG--------FAGL 204
+ IP ++F L+FL+L NR++ + RNG F GL
Sbjct: 204 MSMIPPKIF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGL 262
Query: 205 IKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNE 264
+ EL LEHN LT++N L L L++ N I ++ L +LDL+ N+
Sbjct: 263 NNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQ 322
Query: 265 IKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
+ +D + F + L+ L + +N++ + + L +L T+ L N
Sbjct: 323 LTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNN 369
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 111 bits (278), Expect = 1e-24
Identities = 78/243 (32%), Positives = 119/243 (48%), Gaps = 1/243 (0%)
Query: 68 LRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNT 127
L N++TEL+ F L L L N +S + AF GLY LK L+L +N++ +P
Sbjct: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
Query: 128 TFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLD 187
+L +LQ+L L N +S + F GL L+ L L N+L IPVR + +L+ +
Sbjct: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
Query: 188 LSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCG 247
L+ NR+ + F L L LHL +N++ + F L +L TL L +NK+
Sbjct: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVA 200
Query: 248 MEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVG 307
+ T G L++L N IKAI F P L+ + +N + + L L T+
Sbjct: 201 IR-TLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 259
Query: 308 LSG 310
L+G
Sbjct: 260 LNG 262
Score = 85.1 bits (209), Expect = 1e-16
Identities = 77/270 (28%), Positives = 124/270 (45%), Gaps = 29/270 (10%)
Query: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
++L N I+ + F + + L LHL +N+I + +F+GL+ L+ L L+ NK+ P
Sbjct: 139 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 198
Query: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTI------------- 172
T L LQ L N + ++ + F G LQT+H N ++ +
Sbjct: 199 VAIRT-LGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 257
Query: 173 -------PVRLFWDCR---SLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINF 222
++ F D + SLE L L+ +R L L +LR L L HNQ+ ++
Sbjct: 258 LSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS 317
Query: 223 AHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKIL 282
H R L + LQ N+I + +L+ LDL+ N I++I F T+ +L L
Sbjct: 318 LH--RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 375
Query: 283 LMDNNKLNSLDSKILNSLRSLTTVGLSGNL 312
+ +N+L +L L L L + L GNL
Sbjct: 376 DLTDNQLTTLP---LAGLGGLMHLKLKGNL 402
Score = 76.6 bits (187), Expect = 5e-14
Identities = 54/173 (31%), Positives = 83/173 (47%)
Query: 139 DLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLAR 198
DLS N L+ L P LF+ LR L+ L L N L IP + F SL+ L L N+L +
Sbjct: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
Query: 199 NGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKL 258
L L+ L L+ N ++ + F LSSL L+L N ++ + L+ +
Sbjct: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
Query: 259 DLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
L N I I F+ + +L +L + NN++ L + L +L T+ L+ N
Sbjct: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYN 192
Score = 67.4 bits (163), Expect = 3e-11
Identities = 52/166 (31%), Positives = 75/166 (45%), Gaps = 4/166 (2%)
Query: 9 LGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSL 68
+G P+L I+ ++ + PK L D Q F + T L +L
Sbjct: 226 MGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEIL--TL 283
Query: 69 RHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTT 128
I L +L L L HNQI + + KL+E+ L N+I+ + T
Sbjct: 284 TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADT 341
Query: 129 FTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPV 174
F+QL +LQ LDLS+N + S+HPE F L L L L N L T+P+
Sbjct: 342 FSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPL 387
Score = 43.5 bits (101), Expect = 5e-04
Identities = 26/77 (33%), Positives = 42/77 (54%)
Query: 236 LQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSK 295
L N ++ L G+ LE+L L+GN + I F + +LKIL++ NN+L + ++
Sbjct: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
Query: 296 ILNSLRSLTTVGLSGNL 312
L L SL ++ L NL
Sbjct: 81 ALWELPSLQSLRLDANL 97
>gi|88702793 slit-like 2 [Homo sapiens]
Length = 673
Score = 107 bits (268), Expect = 2e-23
Identities = 109/373 (29%), Positives = 165/373 (44%), Gaps = 32/373 (8%)
Query: 24 LKMLPALG---MACPPKCRCEK-LLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERD 79
L +L ALG CP C+C + +C ++ +VP ++GL + N IT L+
Sbjct: 11 LLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDAG 70
Query: 80 QFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLD 139
FA L L L NQI+++ FQ L L L L++N++ + N TF L L+ L
Sbjct: 71 SFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLY 130
Query: 140 LSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTI-PVRLFWDCRSLEFLDLSTNRLRSLAR 198
L N++ + P F L +L L L+ N LR + P+RL L LDLS N L +L
Sbjct: 131 LGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRL----PRLLLLDLSHNSLLAL-E 185
Query: 199 NGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKL 258
G + L L L +++ F RL +LH L + N++ + + G L +L
Sbjct: 186 PGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRG-LTRL 244
Query: 259 DLTGN----EIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWE 314
L GN +++ DL + L + N L +L + L + + N +
Sbjct: 245 RLAGNTRIAQLRPEDLAGLAALQELDV---SNLSLQALPGDLSGLFPRLRLLAAARNPFN 301
Query: 315 CSARICALASWLGSFQGRWEHSIL-------CHSPDHTQGEDILDAVHGFQLCWNLSTTV 367
C +C L SW G + R H L CH P G +L+ + C +TT
Sbjct: 302 C---VCPL-SWFGPWV-RESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTA 356
Query: 368 TVMAT--TYRDPT 378
TV T R+PT
Sbjct: 357 TVPTTRPVVREPT 369
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.136 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,515,855
Number of Sequences: 37866
Number of extensions: 836948
Number of successful extensions: 5484
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 93
Number of HSP's that attempted gapping in prelim test: 2475
Number of HSP's gapped (non-prelim): 1154
length of query: 516
length of database: 18,247,518
effective HSP length: 107
effective length of query: 409
effective length of database: 14,195,856
effective search space: 5806105104
effective search space used: 5806105104
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.