Guide to the Human Genome
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Search of human proteins with 7661580

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7661580 WD repeat domain, phosphoinositide interacting 2
isoform a [Homo sapiens]
         (454 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7661580 WD repeat domain, phosphoinositide interacting 2 isof...   908   0.0  
gi|75677329 WD repeat domain, phosphoinositide interacting 2 iso...   877   0.0  
gi|54111428 WD repeat domain, phosphoinositide interacting 2 iso...   862   0.0  
gi|75677331 WD repeat domain, phosphoinositide interacting 2 iso...   831   0.0  
gi|75677340 WD repeat domain, phosphoinositide interacting 2 iso...   740   0.0  
gi|157388939 WD repeat domain, phosphoinositide interacting 1 [H...   474   e-134
gi|122939167 WDR45-like [Homo sapiens]                                129   5e-30
gi|71483646 WD repeat domain 45 isoform 2 [Homo sapiens]               96   5e-20
gi|47059042 WD repeat domain 45 isoform 1 [Homo sapiens]               96   7e-20
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     50   4e-06
gi|186928847 cirhin [Homo sapiens]                                     42   0.001
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             38   0.017
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             38   0.022
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             38   0.022
gi|153218631 breast carcinoma amplified sequence 3 isoform 1 [Ho...    37   0.028
gi|153218595 breast carcinoma amplified sequence 3 isoform 2 [Ho...    37   0.028
gi|32189425 WD repeat domain 69 [Homo sapiens]                         37   0.028
gi|26665869 WD repeat domain 51B [Homo sapiens]                        35   0.14 
gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1...    34   0.24 
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom...    34   0.24 
gi|14150171 THO complex 3 [Homo sapiens]                               34   0.24 
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ...    33   0.53 
gi|13376840 WD repeat domain 61 [Homo sapiens]                         33   0.70 
gi|148528998 Dmx-like 1 [Homo sapiens]                                 33   0.70 
gi|157739942 gemin 5 [Homo sapiens]                                    32   0.91 
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...    32   0.91 
gi|38569484 kinesin family member 21A [Homo sapiens]                   32   1.6  
gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform ...    32   1.6  
gi|94400919 WD repeat domain 90 [Homo sapiens]                         32   1.6  
gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]          31   2.0  

>gi|7661580 WD repeat domain, phosphoinositide interacting 2 isoform
           a [Homo sapiens]
          Length = 454

 Score =  908 bits (2346), Expect = 0.0
 Identities = 454/454 (100%), Positives = 454/454 (100%)

Query: 1   MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS 60
           MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS
Sbjct: 1   MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS 60

Query: 61  VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 120
           VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL
Sbjct: 61  VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 120

Query: 121 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 180
           AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT
Sbjct: 121 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 180

Query: 181 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 240
           IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE
Sbjct: 181 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 240

Query: 241 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 300
           FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM
Sbjct: 241 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 300

Query: 301 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 360
           ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD
Sbjct: 301 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 360

Query: 361 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT 420
           PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT
Sbjct: 361 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT 420

Query: 421 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 454
           DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD
Sbjct: 421 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 454


>gi|75677329 WD repeat domain, phosphoinositide interacting 2
           isoform c [Homo sapiens]
          Length = 443

 Score =  877 bits (2266), Expect = 0.0
 Identities = 443/454 (97%), Positives = 443/454 (97%), Gaps = 11/454 (2%)

Query: 1   MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS 60
           MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS
Sbjct: 1   MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS 60

Query: 61  VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 120
           VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL
Sbjct: 61  VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 120

Query: 121 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 180
           AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT
Sbjct: 121 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 180

Query: 181 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 240
           IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE
Sbjct: 181 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 240

Query: 241 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 300
           FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM
Sbjct: 241 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 300

Query: 301 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 360
           ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD
Sbjct: 301 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 360

Query: 361 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT 420
           PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGK           AYT
Sbjct: 361 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGK-----------AYT 409

Query: 421 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 454
           DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD
Sbjct: 410 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 443


>gi|54111428 WD repeat domain, phosphoinositide interacting 2
           isoform b [Homo sapiens]
          Length = 436

 Score =  862 bits (2227), Expect = 0.0
 Identities = 436/454 (96%), Positives = 436/454 (96%), Gaps = 18/454 (3%)

Query: 1   MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS 60
           MNLASQSGEAGAGQLLFANFNQDNT                  SLAVGSKSGYKFFSLSS
Sbjct: 1   MNLASQSGEAGAGQLLFANFNQDNT------------------SLAVGSKSGYKFFSLSS 42

Query: 61  VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 120
           VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL
Sbjct: 43  VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 102

Query: 121 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 180
           AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT
Sbjct: 103 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 162

Query: 181 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 240
           IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE
Sbjct: 163 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 222

Query: 241 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 300
           FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM
Sbjct: 223 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 282

Query: 301 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 360
           ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD
Sbjct: 283 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 342

Query: 361 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT 420
           PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT
Sbjct: 343 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT 402

Query: 421 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 454
           DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD
Sbjct: 403 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 436


>gi|75677331 WD repeat domain, phosphoinositide interacting 2
           isoform d [Homo sapiens]
          Length = 425

 Score =  831 bits (2147), Expect = 0.0
 Identities = 425/454 (93%), Positives = 425/454 (93%), Gaps = 29/454 (6%)

Query: 1   MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS 60
           MNLASQSGEAGAGQLLFANFNQDNT                  SLAVGSKSGYKFFSLSS
Sbjct: 1   MNLASQSGEAGAGQLLFANFNQDNT------------------SLAVGSKSGYKFFSLSS 42

Query: 61  VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 120
           VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL
Sbjct: 43  VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 102

Query: 121 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 180
           AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT
Sbjct: 103 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 162

Query: 181 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 240
           IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE
Sbjct: 163 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 222

Query: 241 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 300
           FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM
Sbjct: 223 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 282

Query: 301 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 360
           ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD
Sbjct: 283 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 342

Query: 361 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT 420
           PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGK           AYT
Sbjct: 343 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGK-----------AYT 391

Query: 421 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 454
           DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD
Sbjct: 392 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 425


>gi|75677340 WD repeat domain, phosphoinositide interacting 2
           isoform e [Homo sapiens]
          Length = 384

 Score =  740 bits (1910), Expect = 0.0
 Identities = 372/383 (97%), Positives = 372/383 (97%), Gaps = 11/383 (2%)

Query: 72  DTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIV 131
           DTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIV
Sbjct: 13  DTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIV 72

Query: 132 CLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTIN 191
           CLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTIN
Sbjct: 73  CLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTIN 132

Query: 192 LRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSI 251
           LRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSI
Sbjct: 133 LRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSI 192

Query: 252 CSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVT 311
           CSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVT
Sbjct: 193 CSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVT 252

Query: 312 EMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMK 371
           EMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMK
Sbjct: 253 EMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMK 312

Query: 372 QHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYTDDLGAVGGACL 431
           QHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGK           AYTDDLGAVGGACL
Sbjct: 313 QHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGK-----------AYTDDLGAVGGACL 361

Query: 432 EDEASALRLDEDSEHPPMILRTD 454
           EDEASALRLDEDSEHPPMILRTD
Sbjct: 362 EDEASALRLDEDSEHPPMILRTD 384


>gi|157388939 WD repeat domain, phosphoinositide interacting 1 [Homo
           sapiens]
          Length = 446

 Score =  474 bits (1219), Expect = e-134
 Identities = 242/411 (58%), Positives = 314/411 (76%), Gaps = 7/411 (1%)

Query: 44  SLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCH 103
           SLA G+K+GYK FSLSSV++L+Q++   +  DV IVERLFSSSLV +VS   PR++ V H
Sbjct: 28  SLATGTKAGYKLFSLSSVEQLDQVHGSNEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYH 87

Query: 104 FKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCA 163
           FKKGTEICNYSYS+ IL+++LNRQRL+VCLEES+YIHNI+DMK+L T+ + P NP GLCA
Sbjct: 88  FKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTLLDIPANPTGLCA 147

Query: 164 LSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEK 223
           LSIN+ N YLAYPGS T GE+ ++D  +L+    I AH+  LAA+ F+ASG+KLA+ASEK
Sbjct: 148 LSINHSNSYLAYPGSLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEK 207

Query: 224 GTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEK 283
           GTVIRVFS+P+GQKL+EFRRG+KR V+I SL FSMD  FL ASSNTETVHIFKLE V   
Sbjct: 208 GTVIRVFSVPDGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKLEQVTNS 267

Query: 284 PPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIP 343
            PEEP+TW+GY GK+ MA+T+YLP+QV++M +Q RAFAT RL F G +NIC+L+TIQK+P
Sbjct: 268 RPEEPSTWSGYMGKMFMAATNYLPTQVSDMMHQDRAFATARLNFSGQRNICTLSTIQKLP 327

Query: 344 RLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAA 403
           RLLV ++ G+LYMYNLDPQ+GGEC L+K H L GS  TT E  ++     P + Q+Y A 
Sbjct: 328 RLLVASSSGHLYMYNLDPQDGGECVLIKTHSLLGS-GTTEENKENDLR--PSLPQSYAAT 384

Query: 404 AGKGTYVPSSPTRLAYTDDLGAVGGACLEDEASA---LRLDEDSEHPPMIL 451
             + +   S+ T   Y++D GA+ G  + +   A   + LD+++E PP+IL
Sbjct: 385 VARPS-ASSASTVPGYSEDGGALRGEVIPEHEFATGPVCLDDENEFPPIIL 434


>gi|122939167 WDR45-like [Homo sapiens]
          Length = 344

 Score =  129 bits (324), Expect = 5e-30
 Identities = 109/363 (30%), Positives = 172/363 (47%), Gaps = 57/363 (15%)

Query: 15  LLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSVDKLEQIYECTDTE 74
           LL+A FNQD+                     A G ++G++ ++   + + E+  E  +  
Sbjct: 13  LLYAGFNQDHG------------------CFACGMENGFRVYNTDPLKEKEK-QEFLEG- 52

Query: 75  DVCIVERLFSSSLVAIVS-----LKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRL 129
            V  VE LF  + +A+V         P K+ +    K   +    +S  + AVKL R R+
Sbjct: 53  GVGHVEMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRI 112

Query: 130 IVCLEESL----YIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQ 185
           +V L+  +    + HN   + V     ET  NP GLC L  N++N  LA+PG+ T G VQ
Sbjct: 113 VVVLDSMIKVFTFTHNPHQLHVF----ETCYNPKGLCVLCPNSNNSLLAFPGTHT-GHVQ 167

Query: 186 VFDTINLRAANM-IPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRG 244
           + D  +     + IPAH+  L+ +A +  GT++ATASEKGT+IR+F    G  + E RRG
Sbjct: 168 LVDLASTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRG 227

Query: 245 VKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTS 304
             +  +I  + F+ D   +  SS+  TVHIF  E  K                  +AS S
Sbjct: 228 -SQAANIYCINFNQDASLICVSSDHGTVHIFAAEDPKRNKQSS------------LASAS 274

Query: 305 YLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEG 364
           +LP    + F+   +F+  ++P  G   IC+  T  +   ++   ADG  Y +  +P+  
Sbjct: 275 FLP----KYFSSKWSFSKFQVP-SGSPCICAFGT--EPNAVIAICADGSYYKFLFNPK-- 325

Query: 365 GEC 367
           GEC
Sbjct: 326 GEC 328


>gi|71483646 WD repeat domain 45 isoform 2 [Homo sapiens]
          Length = 360

 Score = 96.3 bits (238), Expect = 5e-20
 Identities = 65/220 (29%), Positives = 110/220 (50%), Gaps = 18/220 (8%)

Query: 78  IVERLFSSSLVAIVSLKAPRKLKVCHF-----------KKGTEICNYSYSNTILAVKLNR 126
           +VE L  S+L+A+V   +  K                  K   +  ++++  +L+V++  
Sbjct: 53  LVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRH 112

Query: 127 QRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQV 186
            ++++ L+  +Y+++  D        +T  NP GLC L  + +   L +PG    G +Q+
Sbjct: 113 DKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKC-GSLQL 171

Query: 187 FDTINLR-----AANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEF 241
            D  + +     A   I AH S +A ++ +  GT +A+AS+KGT+IR+F     +KL E 
Sbjct: 172 VDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVEL 231

Query: 242 RRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVK 281
           RRG       C + FS D  FL ASS+  TVHIF L+  +
Sbjct: 232 RRGTDPATLYC-INFSHDSSFLCASSDKGTVHIFALKDTR 270


>gi|47059042 WD repeat domain 45 isoform 1 [Homo sapiens]
          Length = 361

 Score = 95.9 bits (237), Expect = 7e-20
 Identities = 56/177 (31%), Positives = 96/177 (54%), Gaps = 7/177 (3%)

Query: 110 ICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINND 169
           +  ++++  +L+V++   ++++ L+  +Y+++  D        +T  NP GLC L  + +
Sbjct: 97  VLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLE 156

Query: 170 NCYLAYPGSATIGEVQVFDTINLR-----AANMIPAHDSPLAALAFDASGTKLATASEKG 224
              L +PG    G +Q+ D  + +     A   I AH S +A ++ +  GT +A+AS+KG
Sbjct: 157 KQLLVFPGHKC-GSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKG 215

Query: 225 TVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVK 281
           T+IR+F     +KL E RRG       C + FS D  FL ASS+  TVHIF L+  +
Sbjct: 216 TLIRLFDTQSKEKLVELRRGTDPATLYC-INFSHDSSFLCASSDKGTVHIFALKDTR 271


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 37/144 (25%), Positives = 69/144 (47%), Gaps = 11/144 (7%)

Query: 158 PAGLCALSINNDNCYLAYPGSATIGE------VQVFDTINLRAANMIPAHDSPLAALAFD 211
           P  + A  + + NC   +P S  +        V+++D +N     +   H  P+ +L F 
Sbjct: 619 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 678

Query: 212 ASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTET 271
            +G  LAT +  G V+ ++ I  G  + E +       ++CSL FS DG  L++ S   T
Sbjct: 679 PNGRFLATGATDGRVL-LWDIGHGLMVGELKGHTD---TVCSLRFSRDGEILASGSMDNT 734

Query: 272 VHIF-KLETVKEKPPEEPTTWTGY 294
           V ++  ++  ++   ++ TT TG+
Sbjct: 735 VRLWDAIKAFEDLETDDFTTATGH 758


>gi|186928847 cirhin [Homo sapiens]
          Length = 686

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 27/96 (28%), Positives = 48/96 (50%), Gaps = 3/96 (3%)

Query: 188 DTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEG--QKLFEFRRGV 245
           D I+L+  + +PA       + F    TKL  AS +G  + +  +  G  + L  F+   
Sbjct: 423 DNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGA-LHIVQLSGGSFKHLHAFQPQS 481

Query: 246 KRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVK 281
               ++C LA S DG +L+AS  +  VH++ ++ +K
Sbjct: 482 GTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLK 517



 Score = 37.0 bits (84), Expect = 0.037
 Identities = 39/147 (26%), Positives = 63/147 (42%), Gaps = 13/147 (8%)

Query: 91  VSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRL-IVCLEESLYIHNIRDMKVLH 149
           +SLK   K+    F +      +S  +T L V  N+  L IV L    + H       LH
Sbjct: 425 ISLKRVSKMPA--FLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKH-------LH 475

Query: 150 TIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALA 209
             +        +C L+++ D  +LA   S T   V V++   L+    +PA++ P+ A+A
Sbjct: 476 AFQPQSGTVEAMCLLAVSPDGNWLA--ASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMA 533

Query: 210 FDASGTKLATASEKGTVIRVFSIPEGQ 236
              +   L  A     V   +SIP+ Q
Sbjct: 534 IAPNTNNLVIAHSDQQVFE-YSIPDKQ 559



 Score = 31.2 bits (69), Expect = 2.0
 Identities = 24/86 (27%), Positives = 42/86 (48%), Gaps = 2/86 (2%)

Query: 182 GEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEF 241
           GE+  +D   L     + A   P+ ++A   SG++L    E G+V ++F I   +  FE 
Sbjct: 81  GEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSV-KLFQITPDKIQFE- 138

Query: 242 RRGVKRCVSICSLAFSMDGMFLSASS 267
           R   ++   I SL++   G  ++A S
Sbjct: 139 RNFDRQKSRILSLSWHPSGTHIAAGS 164


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 38.1 bits (87), Expect = 0.017
 Identities = 35/151 (23%), Positives = 61/151 (40%), Gaps = 22/151 (14%)

Query: 157 NPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTK 216
           +P+G C  +   DN             V+V+D    R       H + +  L+F  SG  
Sbjct: 196 HPSGTCIAAAGMDNT------------VKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243

Query: 217 LATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFK 276
           L TAS   T +++  + EG+ L+          ++   AFS  G + ++  + E V ++K
Sbjct: 244 LITASSDST-LKILDLMEGRLLYTLHGHQGPATTV---AFSRTGEYFASGGSDEQVMVWK 299

Query: 277 --LETVKE----KPPEEPTTWTGYFGKVLMA 301
              + V      K P  P T     G + ++
Sbjct: 300 SNFDIVDHGEVTKVPRPPATLASSMGNLTVS 330


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 37.7 bits (86), Expect = 0.022
 Identities = 29/120 (24%), Positives = 51/120 (42%), Gaps = 16/120 (13%)

Query: 157 NPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTK 216
           +P+G C  +   DN             V+V+D    R       H + +  L+F  SG  
Sbjct: 158 HPSGTCIAAAGMDNT------------VKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 205

Query: 217 LATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFK 276
           L TAS   T +++  + EG+ L+          ++   AFS  G + ++  + E V ++K
Sbjct: 206 LITASSDST-LKILDLMEGRLLYTLHGHQGPATTV---AFSRTGEYFASGGSDEQVMVWK 261


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 37.7 bits (86), Expect = 0.022
 Identities = 29/120 (24%), Positives = 51/120 (42%), Gaps = 16/120 (13%)

Query: 157 NPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTK 216
           +P+G C  +   DN             V+V+D    R       H + +  L+F  SG  
Sbjct: 196 HPSGTCIAAAGMDNT------------VKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243

Query: 217 LATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFK 276
           L TAS   T +++  + EG+ L+          ++   AFS  G + ++  + E V ++K
Sbjct: 244 LITASSDST-LKILDLMEGRLLYTLHGHQGPATTV---AFSRTGEYFASGGSDEQVMVWK 299


>gi|153218631 breast carcinoma amplified sequence 3 isoform 1 [Homo
           sapiens]
          Length = 928

 Score = 37.4 bits (85), Expect = 0.028
 Identities = 30/117 (25%), Positives = 49/117 (41%), Gaps = 13/117 (11%)

Query: 180 TIGEVQVFDTINLRAANMI---PAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEG- 235
           T+GE QV  + +  +  ++   PAH+ P+  +AF+ SG  L T    G    VF I    
Sbjct: 326 TVGEGQVLVSEDSDSDGIVAHFPAHEKPVCCMAFNTSGMLLVTTDTLGHDFHVFQILTHP 385

Query: 236 --------QKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKP 284
                     L+   RG      +  + FS D  ++  S+   T H+F +     +P
Sbjct: 386 WSSSQCAVHHLYTLHRGETE-AKVQDICFSHDCRWVVVSTLRGTSHVFPINPYGGQP 441


>gi|153218595 breast carcinoma amplified sequence 3 isoform 2 [Homo
           sapiens]
          Length = 913

 Score = 37.4 bits (85), Expect = 0.028
 Identities = 30/117 (25%), Positives = 49/117 (41%), Gaps = 13/117 (11%)

Query: 180 TIGEVQVFDTINLRAANMI---PAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEG- 235
           T+GE QV  + +  +  ++   PAH+ P+  +AF+ SG  L T    G    VF I    
Sbjct: 326 TVGEGQVLVSEDSDSDGIVAHFPAHEKPVCCMAFNTSGMLLVTTDTLGHDFHVFQILTHP 385

Query: 236 --------QKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKP 284
                     L+   RG      +  + FS D  ++  S+   T H+F +     +P
Sbjct: 386 WSSSQCAVHHLYTLHRGETE-AKVQDICFSHDCRWVVVSTLRGTSHVFPINPYGGQP 441


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 37.4 bits (85), Expect = 0.028
 Identities = 61/263 (23%), Positives = 106/263 (40%), Gaps = 38/263 (14%)

Query: 37  GRRAVVWSLAVGSKSGYKFFSLSSVDKLEQIY-----ECTDT------EDVCIVERLFSS 85
           G R VV+++A  +  G K  +  S DK  +++     +C  T      E VC+      S
Sbjct: 132 GHRNVVYAIAFNNPYGDKI-ATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNP-QS 189

Query: 86  SLVAIVSLKAPRKLKVCHFKKGTEICNY-SYSNTILAVKLNRQRLIVCLEESLYIHNIRD 144
           +LVA  S+    KL     + G E+     +S  I+++  N     +      +   + D
Sbjct: 190 TLVATGSMDTTAKL--WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247

Query: 145 MKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSP 204
                 +     + A + + S N D C L   GS      +++D  N +    +  HD  
Sbjct: 248 ADTGRKVNILIGHCAEISSASFNWD-CSLILTGSMD-KTCKLWDATNGKCVATLTGHDDE 305

Query: 205 LAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVS--------ICSLAF 256
           +    FD +G  +ATAS  GT  R+FS              ++C++        I  ++F
Sbjct: 306 ILDSCFDYTGKLIATASADGTA-RIFS-----------AATRKCIAKLEGHEGEISKISF 353

Query: 257 SMDGMFLSASSNTETVHIFKLET 279
           +  G  L   S+ +T  I+  +T
Sbjct: 354 NPQGNHLLTGSSDKTARIWDAQT 376


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 35.0 bits (79), Expect = 0.14
 Identities = 26/78 (33%), Positives = 41/78 (52%), Gaps = 8/78 (10%)

Query: 200 AHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVK--RCVSICSLAFS 257
           AH +P+ ++ F A G  LATASE  + I+V+S+   + L+   R     RC       FS
Sbjct: 100 AHTAPVRSVDFSADGQFLATASEDKS-IKVWSMYRQRFLYSLYRHTHWVRCAK-----FS 153

Query: 258 MDGMFLSASSNTETVHIF 275
            DG  + + S  +T+ I+
Sbjct: 154 PDGRLIVSCSEDKTIKIW 171



 Score = 33.9 bits (76), Expect = 0.31
 Identities = 27/117 (23%), Positives = 52/117 (44%), Gaps = 17/117 (14%)

Query: 157 NPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTK 216
           NP+G C  S  +D              V+V+D    +       H   +  ++F  SG  
Sbjct: 195 NPSGTCIASAGSDQT------------VKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNY 242

Query: 217 LATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDG-MFLSASSNTETV 272
           L TAS  GT +++  + EG+ ++  +        + +++FS  G +F S  ++T+ +
Sbjct: 243 LITASSDGT-LKILDLLEGRLIYTLQ---GHTGPVFTVSFSKGGELFASGGADTQVL 295



 Score = 32.3 bits (72), Expect = 0.91
 Identities = 21/77 (27%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 201 HDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDG 260
           H   + ++ F   G  LA+AS   TV R++   +  K  EF+        + S+ FS DG
Sbjct: 59  HKDVVTSVQFSPHGNLLASASRDRTV-RLWIPDKRGKFSEFKA---HTAPVRSVDFSADG 114

Query: 261 MFLSASSNTETVHIFKL 277
            FL+ +S  +++ ++ +
Sbjct: 115 QFLATASEDKSIKVWSM 131


>gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1
           [Homo sapiens]
          Length = 1129

 Score = 34.3 bits (77), Expect = 0.24
 Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 6/101 (5%)

Query: 184 VQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPE-----GQKL 238
           V++ D ++         HD+P+ +L+FD     LA+AS  G+V RV+ I +        L
Sbjct: 118 VKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSV-RVWQISDQTCAISWPL 176

Query: 239 FEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLET 279
            +    V    SIC LA+      L A    ++V +++ E+
Sbjct: 177 LQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRES 217


>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
           sapiens]
          Length = 504

 Score = 34.3 bits (77), Expect = 0.24
 Identities = 24/102 (23%), Positives = 48/102 (47%), Gaps = 6/102 (5%)

Query: 177 GSATI-GEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEG 235
           G+ T+  +++++D          P H  P+ ++AF  +G  LATA++  +V     + + 
Sbjct: 366 GTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSV----KLWDL 421

Query: 236 QKLFEFRR-GVKRCVSICSLAFSMDGMFLSASSNTETVHIFK 276
           +KL  F+   +     + SL F   G +L+       ++I K
Sbjct: 422 RKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICK 463


>gi|14150171 THO complex 3 [Homo sapiens]
          Length = 351

 Score = 34.3 bits (77), Expect = 0.24
 Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 8/117 (6%)

Query: 164 LSINNDN-CYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASE 222
           +S NNDN  +    G+   G + +     L+    I AH S    + FD  G   AT S 
Sbjct: 188 ISWNNDNNMFFLTNGN---GCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSA 244

Query: 223 KGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLET 279
              V    S+ +  +L   R   +    + +L+FS DG  L+++S    + I ++ET
Sbjct: 245 DALV----SLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVET 297


>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
           sapiens]
          Length = 513

 Score = 33.1 bits (74), Expect = 0.53
 Identities = 23/80 (28%), Positives = 39/80 (48%), Gaps = 3/80 (3%)

Query: 202 DSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGM 261
           D  +  + F      LAT ++ G  I+V+ I  GQ L  F R   +   +  L+FS D  
Sbjct: 264 DDAVLCMCFSRDTEMLATGAQDGK-IKVWKIQSGQCLRRFERAHSK--GVTCLSFSKDSS 320

Query: 262 FLSASSNTETVHIFKLETVK 281
            + ++S  +T+ I  L++ K
Sbjct: 321 QILSASFDQTIRIHGLKSGK 340


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 32.7 bits (73), Expect = 0.70
 Identities = 25/119 (21%), Positives = 52/119 (43%), Gaps = 6/119 (5%)

Query: 161 LCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATA 220
           + +++ + D  YLA    A  G + +FD    +  + +  H  P+ +L F      L TA
Sbjct: 151 ILSIAYSPDGKYLA--SGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208

Query: 221 SEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLET 279
           S+ G  I+++ +                  + ++AF  D     +SS+ ++V ++ + T
Sbjct: 209 SDDG-YIKIYDVQHANLAGTLS---GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGT 263



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 41/164 (25%), Positives = 73/164 (44%), Gaps = 18/164 (10%)

Query: 205 LAALAFDASGT-KLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFL 263
           L  ++ D S T  +A +S     IR++ +  G+++     G    V   +LAFS D  +L
Sbjct: 65  LGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGP---VDAWTLAFSPDSQYL 121

Query: 264 SASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMA-----STSYLPSQVTEMFNQGR 318
           +  ++   V+IF +E+ K++   +        GK +++        YL S   +      
Sbjct: 122 ATGTHVGKVNIFGVESGKKEYSLDTR------GKFILSIAYSPDGKYLASGAIDGIINIF 175

Query: 319 AFATVRL--PFCGHKNICSLATIQKIPRLLVGAA-DGYLYMYNL 359
             AT +L     GH       T     +LLV A+ DGY+ +Y++
Sbjct: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV 219


>gi|148528998 Dmx-like 1 [Homo sapiens]
          Length = 3027

 Score = 32.7 bits (73), Expect = 0.70
 Identities = 33/141 (23%), Positives = 55/141 (39%), Gaps = 9/141 (6%)

Query: 92   SLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTI 151
            S+  P     CH K   +    S S+ I    L+     VCL ++L             +
Sbjct: 2826 SMPKPYLTWQCHNKTANDFVFVSSSSLIATAGLSTDNRNVCLWDTLVA------PANSLV 2879

Query: 152  RETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFD 211
                 + +G   L+    +  L   G    G   VFD    +   +  +HDSP+ A+A D
Sbjct: 2880 HAFTCHDSGATVLAYAPKHQLLISGGRK--GFTYVFDLCQRQQRQLFQSHDSPVKAVAVD 2937

Query: 212  ASGTKLATASEKGTVIRVFSI 232
             +     T S +G  I+++S+
Sbjct: 2938 PTEEYFVTGSAEGN-IKIWSL 2957


>gi|157739942 gemin 5 [Homo sapiens]
          Length = 1508

 Score = 32.3 bits (72), Expect = 0.91
 Identities = 32/125 (25%), Positives = 56/125 (44%), Gaps = 10/125 (8%)

Query: 198 IPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSIC---SL 254
           +P H      +++ A G  +A  +E G+ I +F IP  + +   ++  K   +I      
Sbjct: 536 LPVHTE----ISWKADGKIMALGNEDGS-IEIFQIPNLKLICTIQQHHKLVNTISWHHEH 590

Query: 255 AFSMDGMFLSAS-SNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEM 313
               +  +L AS SN   +++  L+TV E  PE P T T  + + L   T+ + S     
Sbjct: 591 GSQPELSYLMASGSNNAVIYVHNLKTVIESSPESPVTITEPY-RTLSGHTAKITSVAWSP 649

Query: 314 FNQGR 318
            + GR
Sbjct: 650 HHDGR 654


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score = 32.3 bits (72), Expect = 0.91
 Identities = 24/91 (26%), Positives = 40/91 (43%), Gaps = 2/91 (2%)

Query: 175 YPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPE 234
           +   A    ++++D  +         H+S + A+AF  +G    T S+  T  R+F +  
Sbjct: 199 FVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDAT-CRLFDLRA 257

Query: 235 GQKLFEFRRGVKRCVSICSLAFSMDGMFLSA 265
            Q+L  +      C  I S+AFS  G  L A
Sbjct: 258 DQELLMYSHDNIIC-GITSVAFSRSGRLLLA 287


>gi|38569484 kinesin family member 21A [Homo sapiens]
          Length = 1661

 Score = 31.6 bits (70), Expect = 1.6
 Identities = 56/277 (20%), Positives = 106/277 (38%), Gaps = 42/277 (15%)

Query: 97   RKLKVCHFKKGTEICNYS-YSNTILAVKLNRQRLIVCLEESLYIH--NIRDM-KVLHTIR 152
            R  KV +   G EI +   + N +++VK      +V    + YI   +IRD  K + T+ 
Sbjct: 1354 RTCKVWNLVTGQEIMSLGGHPNNVVSVKYCNYTSLVFTVSTSYIKVWDIRDSAKCIRTLT 1413

Query: 153  ETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDA 212
             +                      G  T+G+     T    A   IP+ ++ +  +A + 
Sbjct: 1414 SS----------------------GQVTLGDACSASTSRTVA---IPSGENQINQIALNP 1448

Query: 213  SGTKLATASEKGTVIRVFSIPEGQKLFEF--RRGVKRCVSICSLAFSMDGMFLSASSNTE 270
            +GT L  AS  G  +R++ +   Q   +     G   C+++  ++   D   +   S   
Sbjct: 1449 TGTFLYAAS--GNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQISSGQD--LIITGSKDH 1504

Query: 271  TVHIFK-----LETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVT--EMFNQGRAFATV 323
             + +F      L TV      EP  + G     +     +  S+    + ++  +     
Sbjct: 1505 YIKMFDVTEGALGTVSPTHNFEPPHYDGIEALTIQGDNLFSGSRDNGIKKWDLTQKDLLQ 1564

Query: 324  RLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 360
            ++P      +C+L  +   P LL G   G L ++N+D
Sbjct: 1565 QVPNAHKDWVCALGVVPDHPVLLSGCRGGILKVWNMD 1601


>gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform 2
           [Homo sapiens]
          Length = 1006

 Score = 31.6 bits (70), Expect = 1.6
 Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 6/84 (7%)

Query: 201 HDSPLAALAFDASGTKLATASEKGTVIRVFSIPE-----GQKLFEFRRGVKRCVSICSLA 255
           HD+P+ +L+FD     LA+AS  G+V RV+ I +        L +    V    SIC LA
Sbjct: 12  HDAPVLSLSFDPKDIFLASASCDGSV-RVWQISDQTCAISWPLLQKCNDVINAKSICRLA 70

Query: 256 FSMDGMFLSASSNTETVHIFKLET 279
           +      L A    ++V +++ E+
Sbjct: 71  WQPKSGKLLAIPVEKSVKLYRRES 94


>gi|94400919 WD repeat domain 90 [Homo sapiens]
          Length = 1748

 Score = 31.6 bits (70), Expect = 1.6
 Identities = 18/60 (30%), Positives = 34/60 (56%), Gaps = 1/60 (1%)

Query: 182 GEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEF 241
           G +   DT++     +  +H +P+ ALA +    +LAT S+  TV R++ +   Q+L++F
Sbjct: 680 GHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTV-RIWDLATLQQLYDF 738


>gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]
          Length = 770

 Score = 31.2 bits (69), Expect = 2.0
 Identities = 27/98 (27%), Positives = 41/98 (41%), Gaps = 8/98 (8%)

Query: 182 GEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEF 241
           G + V+D  N         H    + +     GTKL T     TV R + + EG++L + 
Sbjct: 596 GNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTV-RSWDLREGRQLQQH 654

Query: 242 RRGVKRCVSICSLAFSMDGMFLSA---SSNTETVHIFK 276
                    I SL +   G +L+    SSN E +H+ K
Sbjct: 655 ----DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNK 688


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,355,035
Number of Sequences: 37866
Number of extensions: 743945
Number of successful extensions: 1745
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 1678
Number of HSP's gapped (non-prelim): 85
length of query: 454
length of database: 18,247,518
effective HSP length: 106
effective length of query: 348
effective length of database: 14,233,722
effective search space: 4953335256
effective search space used: 4953335256
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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